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1. Lai PF, Hsieh SC, Chien JC, Fang CL, Chan WP, Yu C: Malignant transformation of an ovarian mature cystic teratoma: computed tomography findings. Arch Gynecol Obstet; 2005 Apr;271(4):355-7
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  • [Title] Malignant transformation of an ovarian mature cystic teratoma: computed tomography findings.
  • INTRODUCTION: The malignant transformation of an ovarian mature cystic teratoma is rare.
  • We presented such a case of a 46-year-old woman with characteristic computed tomography (CT) findings.
  • Computed tomography images showed a left adnexal mass with fat, calcification and soft tissue components, and areas of invasion through the teratoma wall.
  • OUTCOME: The histologic diagnosis was compatible with a squamous cell carcinoma arising from a mature cystic teratoma of the ovary.
  • [MeSH-major] Carcinoma, Squamous Cell / radiography. Ovarian Neoplasms / pathology. Ovarian Neoplasms / radiography. Teratoma / pathology. Teratoma / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 15551144.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-125 Antigen
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2. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Title] Spiradenocylindrocarcinoma: a malignant hybrid tumor.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • We found 48 cases of malignant spiradenomas and 33 cases of malignant cylindromas reported in the English literature.
  • CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female.
  • CONCLUSION: We propose the term 'spiradenocylindrocarcinoma' to describe malignant tumors with features of both a spiradenoma and a cylindroma.
  • In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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3. Butman JA, Linehan WM, Lonser RR: Neurologic manifestations of von Hippel-Lindau disease. JAMA; 2008 Sep 17;300(11):1334-42
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  • [Title] Neurologic manifestations of von Hippel-Lindau disease.
  • von Hippel-Lindau disease (VHL) is an autosomal-dominant neoplasia syndrome that is the result of a germline mutation of the VHL tumor suppressor gene on the short arm of chromosome 3.
  • Visceral manifestations include renal carcinomas and cysts, pancreatic neuroendocrine tumors and cysts, pheochromocytomas, and cystadenomas of the reproductive adnexal organs.

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  • (PMID = 18799446.001).
  • [ISSN] 1538-3598
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / BC / Z01 BC011038-01; United States / NCI NIH HHS / BC / Z01 BC011089-01; United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Clinical Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  • [Other-IDs] NLM/ NIHMS410216; NLM/ PMC3487164
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4. Pedamallu SB, Murphy J, Boyd D, Martin-Hirsch D, Al-Zwae K: Direct intracranial extension of malignant eccrine spiradenoma of the face. J Clin Med Res; 2009 Aug;1(3):181-3
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  • [Title] Direct intracranial extension of malignant eccrine spiradenoma of the face.
  • Malignant eccrine spiradenomas are exceedingly rare tumours.
  • We present a case of malignant eccrine spiradenoma of the right side of the face with direct intracranial extension without distant metastasis.
  • Histopathological findings were consistent with malignant eccrine spiradenoma.
  • This is a rare case of facial malignant eccrine spiradenoma with direct intracranial extension with no distant metastasis.
  • KEYWORDS: Eccrine carcinoma; Spiradenoma; Adnexal carcinoma; Malignant eccrine spiradenoma.

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  • (PMID = 22493654.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3318883
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5. Skafida E, Grammatoglou X, Katsamagkou E, Glava Ch, Firfiris N, Vasilakaki T: Primary malignant mixed müillerian tumour of the fallopian tube. Report of a case. Eur J Gynaecol Oncol; 2010;31(1):126-8
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  • [Title] Primary malignant mixed müillerian tumour of the fallopian tube. Report of a case.
  • Malignant mixed müllerian tumour of the fallopian tube is an extremely rare lesion and to date only approximately 50 cases have been reported.
  • We report a case of a 60-year-old woman who presented to our hospital with pelvic pain.
  • Ultrasound and abdominal and pelvic computed tomography showed a left adnexal mass.
  • Grossly the left side of the fallopian tube was dilated and the cut surface revealed a solid mass filling the entire lumen.
  • Histological examinations showed a malignant mixed müllerian tumour.
  • The carcinomatous element was composed of well to moderately differentiated squamous cell carcinoma and the sarcomatous component was made up of anaplastic spindle shaped cells with hyperchromatic nuclei.
  • The prognosis of a primary malignancy of the fallopian tube is poor and depends more on staging than on histologic type and grade.
  • [MeSH-minor] Carcinoma / pathology. Carcinoma, Squamous Cell / pathology. Female. Humans. Middle Aged

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  • (PMID = 20349800.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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6. Rütten A, Requena L: [Sweat gland carcinomas of the skin]. Hautarzt; 2008 Feb;59(2):151-60
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  • [Title] [Sweat gland carcinomas of the skin].
  • Sweat gland carcinomas are rare malignant tumors of the skin.
  • The well-defined entities porocarcinoma, microcystic adnexal carcinoma, aggressive digital papillary adenocarcinoma, mucinous eccrine carcinoma, adenoid cystic carcinoma, spiradenocarcinoma, cylindrocarcinoma, hidradenocarcinoma are described.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / therapy

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  • (PMID = 18214401.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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7. Sicinska J, Rakowska A, Czuwara-Ladykowska J, Mroz A, Lipinski M, Nasierowska-Guttmejer A, Sikorska J, Sklinda K, Slowinska M, Kowalska-Oledzka E, Walecka I, Walecki J, Rudnicka L: Cylindroma transforming into basal cell carcinoma in a patient with Brooke-Spiegler syndrome. J Dermatol Case Rep; 2007 Dec 29;1(1):4-9
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  • [Title] Cylindroma transforming into basal cell carcinoma in a patient with Brooke-Spiegler syndrome.
  • BACKGROUND: Brooke-Spiegler syndrome is a rare condition with a predisposition to develop cutaneous adnexal neoplasms, especially cylindromas, trichoepitheliomas and spiradenomas.
  • Malignant transformation of cylindromas is rare.
  • We present an unusual case of basal cell carcinoma developing within a preexisting cylindroma.
  • Histopathology confirmed cylindromas and basal cell carcinoma within the ulcerating tumor.
  • CONCLUSION: Patients with Brooke-Spiegler syndrome should be followed-up for malignant transformation of skin tumors to prevent deep penetration and possible metastases.

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  • (PMID = 21886698.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157764
  • [Keywords] NOTNLM ; basal cell carcinoma / computed tomography / cylindroma / magnetic resonance imaging / syringoma / trichoepithelioma / turban tumor
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8. Chi DS, Abu-Rustum NR, Sonoda Y, Ivy J, Rhee E, Moore K, Levine DA, Barakat RR: The safety and efficacy of laparoscopic surgical staging of apparent stage I ovarian and fallopian tube cancers. Am J Obstet Gynecol; 2005 May;192(5):1614-9
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  • OBJECTIVE: To compare the safety and efficacy of laparoscopic staging of ovarian or fallopian tube cancers to staging via laparotomy for epithelial ovarian carcinoma.
  • STUDY DESIGN: We performed a case-control study of all patients with apparent stage I adnexal cancers who had laparoscopic staging from October 2000 to March 2003.
  • The control group consisted of all patients with apparent stage I epithelial ovarian carcinoma who had staging via laparotomy during the same time period.
  • [MeSH-minor] Adult. Blood Loss, Surgical. Carcinoma / pathology. Case-Control Studies. Female. Humans. Laparotomy / adverse effects. Length of Stay. Lymph Node Excision. Lymph Nodes / pathology. Middle Aged. Omentum / pathology

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  • (PMID = 15902166.001).
  • [ISSN] 0002-9378
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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9. Ramos-Ceballos FI, Pashaei S, Kincannon JM, Morgan MB, Smoller BR: Bcl-2, CD34 and CD10 expression in basaloid follicular hamartoma, vellus hair hamartoma and neurofollicular hamartoma demonstrate full follicular differentiation. J Cutan Pathol; 2008 May;35(5):477-83
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  • BFH is a benign adnexal tumor that resembles basal cell carcinoma (BCC).

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  • [CommentIn] J Cutan Pathol. 2009 May;36(5):603; author reply 604 [19476535.001]
  • (PMID = 18399809.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Proto-Oncogene Proteins c-bcl-2; EC 3.4.24.11 / Neprilysin
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10. Kim YJ, Kim AR, Yu DS: Mohs micrographic surgery for squamoid eccrine ductal carcinoma. Dermatol Surg; 2005 Nov;31(11 Pt 1):1462-4
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  • [Title] Mohs micrographic surgery for squamoid eccrine ductal carcinoma.
  • BACKGROUND: Squamoid eccrine ductal carcinoma is a rare cutaneous malignancy.
  • There are no accepted standards for surgical margins in eccrine carcinomas.
  • OBJECTIVE: We report a case of squamoid eccrine ductal carcinoma resembling squamous cell carcinoma and discuss Mohs micrographic surgery as a surgical modality for eccrine carcinomas.
  • METHOD: The patient was a 30-year-old Korean woman with a 4-year history of a nodule on her neck.
  • Following primary diagnosis of squamous cell carcinoma by punch biopsy, the tumor was completely removed by Mohs micrographic surgery with a 2 mm cancer-free margin.
  • Although eccrine carcinomas show a generally aggressive clinical course, the patient was disease free at 14 months after surgery.
  • DISCUSSION: Squamoid eccrine ductal carcinoma should be considered in the differential diagnosis of squamous cell carcinoma and other cutaneous adnexal neoplasms showing squamoid and ductal features of differentiation.
  • In addition, Mohs micrographic surgery can be an option sufficient for complete surgical removal of eccrine carcinomas such as squamoid eccrine ductal carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Eccrine Glands / pathology. Head and Neck Neoplasms / surgery. Mohs Surgery. Sweat Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • [CommentIn] Dermatol Surg. 2011 Dec;37(12):1819-20 [22182240.001]
  • (PMID = 16416622.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G: How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. J Am Acad Dermatol; 2010 Sep;63(3):377-86; quiz 387-8
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  • [Title] How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors.
  • Nonmelanoma skin cancer refers to a broad class of tumors, including actinic keratosis, basal cell carcinoma, and squamous cell carcinoma, and as a group these are the most frequent cancers occurring in light skinned humans.
  • In contrast to the rarity of amelanotic melanoma, nonmelanoma skin cancer commonly lacks pigmentation.
  • Dermoscopy improves the clinical diagnosis of nonpigmented skin tumors by allowing the visualization of specific vascular structures that are usually not visible to the naked eye.
  • Dermoscopic vascular patterns of several nonmelanocytic nonpigmented skin tumors, such as sebaceous hyperplasia, seborrheic keratosis, clear cell acanthoma, Bowen disease, or nodular cystic basal cell carcinoma are highly specific, allowing a ready diagnosis in most cases.
  • Others, such as actinic keratosis, pyogenic granuloma, or uncommon adnexal tumors, may be difficult to differentiate even with the aid of dermoscopy.
  • In the second part of this review of dermoscopic vascular structures of nonpigmented skin tumors, the dermoscopic patterns associated with benign and malignant nonmelanocytic skin tumors and recommendations for the management of these tumors will be discussed.
  • [MeSH-major] Dermoscopy / methods. Skin / blood supply. Skin Neoplasms / blood supply. Skin Neoplasms / diagnosis
  • [MeSH-minor] Blood Vessels / pathology. Bowen's Disease / blood supply. Bowen's Disease / diagnosis. Bowen's Disease / pathology. Carcinoma, Basal Cell / blood supply. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Education, Medical, Continuing. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / pathology. Male. Melanoma, Amelanotic / blood supply. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology


12. Kazakov DV, Vittay G, Michal M, Calonje E: High-grade trichoblastic carcinosarcoma. Am J Dermatopathol; 2008 Feb;30(1):62-4
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  • We view the present case and that previously reported in 2004 as authentic carcinosarcomas, and not as metaplastic (sarcomatoid) basal cell carcinomas.
  • This conclusion is reached after analyzing the embryological development of the hair follicle, its normal histology and the morphology of cutaneous adnexal tumors with follicular differentiation.
  • [MeSH-major] Carcinosarcoma / pathology. Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Ear / pathology. Humans. Immunohistochemistry. Male

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  • (PMID = 18212548.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Fang W, Chen D, Shang JF, Wang F, Xiao L: [Microcystic adnexal carcinoma: report of two cases]. Zhonghua Bing Li Xue Za Zhi; 2009 Jan;38(1):59-60
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  • [Title] [Microcystic adnexal carcinoma: report of two cases].
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Arm. Carcinoembryonic Antigen / metabolism. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Male. Middle Aged. Mucin-1 / metabolism

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  • (PMID = 19489229.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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14. Gabillot-Carré M, Weill F, Mamelle G, Kolb F, Boitier F, Petrow P, Ortoli JC, Margulis A, Souteyrand P, Mercier S, Spatz A, Duvillard P, Validire P, Avril MF: Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. Dermatology; 2006;212(3):221-8
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  • [Title] Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm, with a high rate of local recurrences.
  • In 3 patients, the course of the disease was severe: one of them developed pathologically proven lung metastasis.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Lung Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • [Copyright] 2006 S. Karger AG, Basel
  • (PMID = 16549917.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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15. Morice P, Fourchotte V, Sideris L, Gariel C, Duvillard P, Castaigne D: A need for laparoscopic evaluation of patients with endometrial carcinoma selected for conservative treatment. Gynecol Oncol; 2005 Jan;96(1):245-8
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  • [Title] A need for laparoscopic evaluation of patients with endometrial carcinoma selected for conservative treatment.
  • BACKGROUND: The aim of this paper was to report two cases of extrauterine disease in patients with early stage endometrial cancer (EC) who desired fertility-sparing management.
  • The two patients, aged 35 and 36 years old, had a grade 1 and grade 2 EC diagnosed after curettage or hysteroscopic resection of a polyp.
  • A small ovarian carcinoma was found in one patient and isolated positive peritoneal cytology in the other.
  • CONCLUSIONS: These cases seem to suggest that laparoscopic evaluation including adnexal exploration and peritoneal cytology (and possibly pelvic lymphadenectomy) should be performed in patients with early stage EC selected for conservative management to confirm the absence of extrauterine disease.
  • [MeSH-major] Endometrial Neoplasms / diagnosis. Endometrial Neoplasms / surgery
  • [MeSH-minor] Adult. Cystadenocarcinoma / diagnosis. Cystadenocarcinoma / surgery. Female. Fertility. Humans. Hysterectomy. Laparoscopy. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery

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  • [CommentIn] Gynecol Oncol. 2005 Jul;98(1):175; author reply 176 [15896833.001]
  • (PMID = 15589610.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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16. Lanitis S, Sivakumar S, Behranwala K, Zacharakis E, Al Mufti R, Hadjiminas DJ: A case of Meigs syndrome mimicking metastatic breast carcinoma. World J Surg Oncol; 2009;7:10
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  • [Title] A case of Meigs syndrome mimicking metastatic breast carcinoma.
  • BACKGROUND: Adnexal masses are not uncommon in patients with breast cancer.
  • In patients with breast cancer and co-existing pleural effusions, ascites and adnexal masses, the probability of disseminated disease is high.
  • CASE PRESENTATION: A 56-year old woman presented with a 4 cm, grade 2, invasive ductal carcinoma of her left breast.
  • Serum tumour markers showed a raised CA125 supporting the malignant nature of the ovarian mass.
  • The patient was strongly against mastectomy and she was commenced on neo-adjuvant Letrozole 2.5 mg daily with a view to perform breast conserving surgery.
  • CONCLUSION: Despite the high probability of disseminated malignancy when an ovarian mass associated with ascites if found in a patient with a breast cancer and pleural effusion, clinicians should be aware about rare benign syndromes, like Meigs', which may mimic a similar picture and mislead the diagnosis and management plan.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Ductal, Breast / diagnosis. Fibroma / diagnosis. Meigs Syndrome / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. CA-125 Antigen / blood. Diagnosis, Differential. Female. Gynecologic Surgical Procedures. Humans. Mastectomy. Middle Aged. Nitriles / therapeutic use. Pleural Effusion / diagnosis. Pleural Effusion / drug therapy. Triazoles / therapeutic use

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  • [Cites] Radiology. 2000 Jul;216(1):242-7 [10887255.001]
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  • (PMID = 19161612.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / CA-125 Antigen; 0 / Nitriles; 0 / Triazoles; 7LKK855W8I / letrozole
  • [Other-IDs] NLM/ PMC2633000
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17. González-Guerra E, Requena L, Kutzner H: [Immunohistochemical study of calretinin in normal hair follicles and tumors with follicular differentiation]. Actas Dermosifiliogr; 2008 Jul-Aug;99(6):456-63
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  • [Transliterated title] Estudio inmunohistoquímico de la calretinina en el folículo piloso normal y neoplasias con diferenciación folicular.
  • OBJECTIVE: The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.
  • MATERIAL AND METHODS: We analyzed the staining pattern for calretinin by immunohistochemistry in 49 biopsies of cutaneous adnexal tumors with follicular differentiation.
  • Three were basal cell carcinomas with variable staining according to the type of follicular differentiation in each variant.
  • CONCLUSION: Immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors of the hair follicle or a component of the follicle with differentiation towards cells of the outer root sheath.
  • [MeSH-major] Hair Follicle / chemistry. Neoplasm Proteins / analysis. S100 Calcium Binding Protein G / analysis. Skin Neoplasms / chemistry
  • [MeSH-minor] Acanthoma / chemistry. Acanthoma / pathology. Calbindin 2. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / chemistry. Carcinoma, Skin Appendage / pathology. Cell Differentiation. Epidermal Cyst / metabolism. Epidermal Cyst / pathology. Hamartoma / metabolism. Hamartoma / pathology. Humans. Neoplasms, Basal Cell / chemistry. Neoplasms, Basal Cell / pathology. Skin Diseases / metabolism. Skin Diseases / pathology

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  • (PMID = 18558053.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G
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18. Martorell-Calatayud A, Requena-Caballero C, Botella-Estrada R, Almenar-Medina S, Sanmartín-Jiménez O, Llombart-Cussac B, Nagore-Enguídanos E, Serra-Guillén C, Echeverría-García B, Guillén-Barona C: [Microcystic adnexal carcinoma: Mohs micrographic surgery as the treatment of choice]. Actas Dermosifiliogr; 2009 Oct;100(8):693-9
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  • [Title] [Microcystic adnexal carcinoma: Mohs micrographic surgery as the treatment of choice].
  • [Transliterated title] Carcinoma anexial microquístico: la cirugía micrográfica de Mohs como tratamiento de elección.
  • INTRODUCTION AND OBJECTIVES: Microcystic adnexal carcinoma is a rare and aggressive tumor that manifests clinically as a subcutaneous nodule located on the head or neck.
  • The tumor can be confused clinically and histologically with other benign and malignant skin lesions, often leading to inappropriate initial treatment.
  • The chief concern with microcystic adnexal carcinoma is the elevated morbidity and the high rate of recurrence after wide local excision.
  • MATERIAL AND METHODS: We reviewed the medical histories of 6 consecutive patients with microcystic adnexal carcinoma who underwent Mohs micrographic surgery in our dermatology department between 1995 and 2007.
  • Seventy percent of the tumors were wrongly diagnosed initially as basal cell carcinoma.
  • The site and the absence of recurrence in all our patients who underwent Mohs micrographic surgery support the use of this technique as the treatment of choice in microcystic adnexal carcinoma.
  • [MeSH-major] Carcinoma / surgery. Facial Neoplasms / surgery. Mohs Surgery. Skin Neoplasms / surgery

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  • (PMID = 19775547.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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19. Valenzuela AA, Whitehead KJ, Sullivan TJ: Ocular adnexal pseudo-cyst formation as a characteristic feature of perineural spread in squamous cell carcinoma. Ophthal Plast Reconstr Surg; 2006 May-Jun;22(3):201-5
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  • [Title] Ocular adnexal pseudo-cyst formation as a characteristic feature of perineural spread in squamous cell carcinoma.
  • PURPOSE: To report the clinical features in a series of patients with perineural spread of squamous cell carcinoma involving periorbital nerves that presented with clinical and/or imaging evidence of pseudo-cystic transformation along the involved nerves.
  • METHODS: A noncomparative, retrospective chart review of the clinical and imaging findings of patients attending a regional orbital surgery department between 1998 and 2005, presenting with a pseudo-cystic orbital mass on clinical examination and/or imaging, which proved to be due to perineural squamous cell carcinoma on histopathology.
  • All cases had associated cutaneous squamous cell carcinoma involving the face or scalp, and, in 4 cases, the primary tumor could be identified in the vicinity of the affected orbit.
  • This demonstrated malignant squamous epithelium both within and around the wall of the tumor deposit and, in continuity, within the nerve running through the lesion.
  • Eight patients (87.5%) remain alive, and five of them show no evidence of disease.
  • CONCLUSIONS: The presence of a cystic lesion in association with sensory or motor deficit in the periorbital region should suggest a diagnosis of perineural spread from a cutaneous squamous cell carcinoma.
  • Because these patients may present to the ophthalmologist first, an awareness of this entity is of critical importance to avoid the delayed diagnosis seen in half of our cases.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Cranial Nerve Neoplasms / secondary. Cysts / diagnosis. Orbital Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 16714930.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Ostler DA, Prieto VG, Reed JA, Deavers MT, Lazar AJ, Ivan D: Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol; 2010 Apr;23(4):567-73
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  • A total of 117 cutaneous clear cell lesions including 16 sebaceous adenomas, 25 sebaceous carcinomas, 8 basal cell carcinomas, 12 squamous cell carcinomas, 6 xanthomas, 10 xanthelasmas, 10 xanthogranulomas, 4 balloon cell nevi, 5 trichilemmomas, 8 clear cell hidradenomas, and 13 metastatic renal cell carcinomas were examined using immunohistochemistry for the expression of adipophilin.
  • Adipophilin was expressed in 16 of 16 (100%) sebaceous adenomas, 23 of 25 (92%) sebaceous carcinomas, 10 of 10 (100%) xanthelasmas, 9 of 10 (90%) xanthogranulomas, 6 of 6 (100%) xanthomas, and 9 of 13 (62.5%) metastatic renal cell carcinomas.
  • Adipophilin expression was not seen in any of the other lesions with clear cell histology, basal cell carcinomas, or squamous cell carcinomas, including cases that had focal clear cell differentiation.
  • In periocular lesions, it is effective in helping to exclude basal cell carcinoma and squamous cell carcinoma when sebaceous carcinoma is under consideration.
  • Adipophilin expression is not as useful for the differential diagnosis that includes metastatic renal cell carcinoma, a rare but important, diagnostic differential.
  • [MeSH-major] Biomarkers, Tumor / analysis. Peptides / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Membrane Proteins. Middle Aged. Neoplasms, Adnexal and Skin Appendage / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Young Adult

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  • (PMID = 20118912.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / Peptides; 0 / perilipin 2
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21. Baloglu A, Bezircioglu I, Cetinkaya B, Hicyilmaz L: Prospective clinical study of the association between plasma level of free IGF-1 and myometrial invasion min patients with endometrial adenocarcinoma. Ginekol Pol; 2010 Jul;81(7):501-5
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  • INTRODUCTION: Endometrial carcinoma is a common malignancy of the female genital tract.
  • Increasing myometrial penetration is associated with an increasing risk of pelvic and para-aortic lymph node metastasis, adnexal metastasis, positive peritoneal cytology local vault recurrence, and hematogenous spread.
  • MATERIAL AND METHODS: Patients with endometrial carcinoma have been divided into three groups: tumor confined to the endometrium (stage IA, n:24), endometrial carcinoma with a minimal invasion (less than 50% of the myometrium; stage IB, n:32), and the control group (n:40).
  • CONCLUSIONS: In the following work we have presented the current understanding of endometrial carcinoma, association between free IGF-1 plasma levels and myometrial invasion in patients with endometrial adenocarcinoma in terms of management and survival.

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  • (PMID = 20825050.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 4TI98Z838E / Estradiol; 67763-96-6 / Insulin-Like Growth Factor I
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22. Palamaras I, McKenna JD, Robson A, Barlow RJ: Microcystic adnexal carcinoma: a case series treated with mohs micrographic surgery and identification of patients in whom paraffin sections may be preferable. Dermatol Surg; 2010 Apr;36(4):446-52
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  • [Title] Microcystic adnexal carcinoma: a case series treated with mohs micrographic surgery and identification of patients in whom paraffin sections may be preferable.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare cutaneous tumor characterized by aggressive local infiltration, including a high propensity for perineural invasion (PNI).
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Facial Neoplasms / pathology. Facial Neoplasms / surgery. Mohs Surgery / methods. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Adnexal and Skin Appendage / surgery
  • [MeSH-minor] Adult. Aged. Eye Enucleation. Female. Frozen Sections. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm, Residual / diagnosis. Neoplasm, Residual / pathology. Neoplasm, Residual / surgery. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery. Photomicrography. Retrospective Studies. Treatment Outcome

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  • (PMID = 20180834.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Hansen T, Kingsley M, Mallatt BD, Krishnan R: Extrafacial microcystic adnexal carcinoma: case report and review of the literature. Dermatol Surg; 2009 Nov;35(11):1835-9
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  • [Title] Extrafacial microcystic adnexal carcinoma: case report and review of the literature.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 19691664.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lewis Blood-Group System
  • [Number-of-references] 36
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24. Goldberg LH, Kimyai-Asadi A: Diffuse epidermal and periadnexal squamous cell carcinoma in situ: a report of 13 patients. J Am Acad Dermatol; 2005 Oct;53(4):623-7
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  • [Title] Diffuse epidermal and periadnexal squamous cell carcinoma in situ: a report of 13 patients.
  • BACKGROUND: Diffuse epidermal and periadnexal squamous cell carcinoma in situ (DEPS) is a condition in which large areas of skin are affected by atypical keratinocytes that grow beneath the epidermis and encase adnexal epithelia.
  • Normal differentiation of the overlying epidermis and adnexal epithelium is seen.
  • Histologic examination showed a growth of atypical keratinocytes in the lower epidermis with encasement of adnexal structures by atypical neoplastic keratinocytes.
  • In the 52 cumulative patient-years of follow-up, we treated 80 invasive squamous cell and 48 basal cell carcinomas in these patients.
  • CONCLUSION: DEPS is characterized by diffuse involvement of chronically sun-exposed skin with atypical keratinocytes that grow along the inferior portion of the basal layer of the epidermis and around adnexal structures.
  • DEPS is also associated with the development of invasive squamous cell and basal cell carcinomas.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Epidermis / pathology. Facial Neoplasms / pathology. Keratinocytes / pathology. Skin Neoplasms / pathology

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  • (PMID = 16198782.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Dietrich CS 3rd, Desimone CP, Modesitt SC, Depriest PD, Ueland FR, Pavlik EJ, Kryscio R, Cibull M, Huh W, Partridge E, Numnum TM, Schilder J, Higgins RV, van Nagell JR 2nd: Primary appendiceal cancer: gynecologic manifestations and treatment options. Gynecol Oncol; 2007 Mar;104(3):602-6
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  • Thirty-one patients (65%) presented with a right adnexal or right lower quadrant mass and were operated on initially by a gynecologic oncologist.
  • Following surgery, 22 patients (46%) experienced disease progression or recurrence, and 14 have died of disease.
  • The appendix should be examined intraoperatively, and if appendiceal carcinoma is identified, a right hemicolectomy and appropriate surgical staging should be considered.

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  • [CommentIn] Gynecol Oncol. 2007 Dec;107(3):592; author reply 592-3 [17765296.001]
  • (PMID = 17055559.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Matsushita S, Uemura T, Imayama S, Sugihara H, Yamasaki M: Giant microcystic adnexal carcinoma of the scalp. J Dermatol; 2008 Nov;35(11):726-8
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  • [Title] Giant microcystic adnexal carcinoma of the scalp.
  • Microcystic adnexal carcinoma (MAC) is an uncommon, locally aggressive tumor.
  • Resection included the cranium; for reconstruction we used a titan mesh allograft and covered it with a free latissimus dorsi muscle flap and a mesh skin graft.
  • Ours is the first case of a MAC measuring more than 100 cm2 arising on the scalp of an individual in the third decade of life.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • [ErratumIn] J Dermatol. 2008 Dec;35(12):808
  • (PMID = 19120767.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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27. Köstler E, Schönlebe J, Mentzel T, Haroske G, Wollina U: Psoriasis and Brooke-Spiegler syndrome with multiple malignancies. J Eur Acad Dermatol Venereol; 2005 May;19(3):380-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / complications. Parotid Neoplasms / pathology. Psoriasis / etiology. Skin Neoplasms / pathology


28. Jeon S, Paik JS, Yang SW: A case of microcystic adnexal carcinoma. Jpn J Ophthalmol; 2010 Jan;54(1):104-5
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  • [Title] A case of microcystic adnexal carcinoma.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Eyelid Neoplasms / pathology

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  • [Cites] Cancer. 1982 Aug 1;50(3):566-72 [7093897.001]
  • [Cites] Mod Pathol. 2008 Feb;21(2):178-85 [18065959.001]
  • [Cites] Nippon Ganka Gakkai Zasshi. 1998 Apr;102(4):281-6 [9594546.001]
  • [Cites] Am J Surg Pathol. 2001 Apr;25(4):464-71 [11257620.001]
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  • (PMID = 20151289.001).
  • [ISSN] 1613-2246
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-15; 0 / Keratin-20
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29. Mane DR, Kale AD, Hallikerimath S, Angadi P, Kotrashetti V: Trichilemmal carcinoma associated with xeroderma pigmentosa: report of a rare case. J Oral Sci; 2010 Sep;52(3):505-7
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  • [Title] Trichilemmal carcinoma associated with xeroderma pigmentosa: report of a rare case.
  • Trichilemmal carcinoma is a rare malignant skin adnexal tumor derived from the outer root sheath epithelium of the hair follicle.
  • We describe a rare case of trichilemmal carcinoma of the upper lip associated with xeroderma pigmentosa in a young patient.
  • We demonstrate that this tumor, as well as the more frequently reported squamous cell carcinoma and basal cell carcinoma can occur in association with xeroderma pigmentosa.
  • Making this diagnosis is imperative as the biological behavior of Trichilemmal carcinoma is less aggressive than that of other epithelial malignancies, requiring a different approach to treatment planning.
  • [MeSH-major] Carcinoma, Skin Appendage / complications. Facial Neoplasms / complications. Hair Follicle / pathology. Lip Neoplasms / complications. Xeroderma Pigmentosum / complications
  • [MeSH-minor] Adult. Consanguinity. Diagnosis, Differential. Humans. Male

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  • (PMID = 20881348.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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30. He XL, Wang CN, Zhang JM: [Clear cell papillary cystadenoma of left mesosalpinx associated with von Hippel-Lindau disease: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2009 May;38(5):349-50
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  • [Title] [Clear cell papillary cystadenoma of left mesosalpinx associated with von Hippel-Lindau disease: report of a case].
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Cystadenoma, Papillary / pathology. Fallopian Tube Neoplasms / pathology. von Hippel-Lindau Disease / pathology
  • [MeSH-minor] Adenoma / pathology. Adnexal Diseases / pathology. Adult. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Keratin-7 / metabolism. Kidney Neoplasms / pathology. Kidney Neoplasms / secondary. Mucin-1 / metabolism

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  • (PMID = 19575884.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Mucin-1; Wolffian tumor
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31. Mebazaa A, Boussofara L, Trabelsi A, Denguezli M, Sriha B, Belajouza C, Nouira R: Undifferentiated sebaceous carcinoma: an unusual childhood cancer. Pediatr Dermatol; 2007 Sep-Oct;24(5):501-4
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  • [Title] Undifferentiated sebaceous carcinoma: an unusual childhood cancer.
  • Sebaceous carcinoma is an aggressive, adnexal, rare malignant tumor that may arise in ocular or extra-ocular sites.
  • Extraorbital sebaceous carcinoma is exceptional in childhood.
  • We report a 12-year-old boy with an ocular sebaceous carcinoma who was first seen with an asymptomatic firm, cutaneous nodule on the right eyebrow.
  • Histologically, it was an undifferentiated sebaceous carcinoma.
  • He was alive and free from disease at a follow-up of 34 months.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Eyebrows / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17958796.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Jakobiec FA, Hanna E, Townsend DJ: Basal cell carcinoma of the eyelid with exceptional histomorphologic expressions. Ophthal Plast Reconstr Surg; 2009 May-Jun;25(3):232-4
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  • [Title] Basal cell carcinoma of the eyelid with exceptional histomorphologic expressions.
  • A basal cell carcinoma of the eyelid had unique and potentially confusing histopathologic features.
  • The tumor displayed a carcinoma in situ pattern with replacement of an extensive segment of the tarsal epithelium by neoplastic basaloid cells, a finding to the best of the authors' knowledge that has not been previously documented.
  • Within the infiltrating component of the dermis were classical solid basaloid nests and lobules; they were accompanied, however, by a separate and exceptionally prominent component of duct-like (pseudoglandular) units mimicking a microcystic adnexal carcinoma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 19454940.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Hoekstra AV, Riben MW, Frumovitz M, Liu J, Ramirez PT: Well-differentiated papillary mesothelioma of the peritoneum: a pathological analysis and review of the literature. Gynecol Oncol; 2005 Jul;98(1):161-7
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  • BACKGROUND: Well-differentiated papillary mesothelioma (WDPM) of the peritoneum is a rare subtype of peritoneal epithelioid mesothelioma which typically has low malignant potential.
  • CASE REPORT: A 74-year-old asymptomatic woman without significant past medical history underwent workup and subsequent surgery for an adnexal mass with a normal serum CA-125 level.
  • Our patient did not receive adjuvant therapy and was without clinical or radiologic evidence of disease 12 months after diagnosis.
  • [MeSH-major] Carcinoma, Papillary / pathology. Mesothelioma / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 15894368.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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34. Kavand S, Cassarino DS: "Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma? Am J Dermatopathol; 2009 Dec;31(8):849-52
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  • [Title] "Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma?
  • Squamoid eccrine ductal carcinoma is a rare primary cutaneous tumor exhibiting both squamous and adnexal ductal differentiation.
  • The cell of origin of these tumors is unknown, and they have been classified both as variants of cutaneous squamous cell carcinoma and as a type of eccrine carcinoma.
  • We report an additional case of a slow-growing tumor, occurring on the great toe of a 61-year-old woman, which was unusual as it showed follicular differentiation in addition to squamoid and ductal areas.
  • We postulate that these tumors may be closely related to microcystic adnexal carcinoma and similarly show differentiation along both follicular and ductal lines, likely indicating folliculosebaceous-apocrine, rather than eccrine, origin or differentiation.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Hair Follicle / pathology. Skin Neoplasms / pathology

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  • (PMID = 19786851.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Ornellas AA, Frota R, Lopes da Silva LF, Dauster B, Quirino R, de Santos Schwindt AB, Pereira MR: Sebaceous carcinoma of the penis. Urol Int; 2009;82(4):477-80
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  • [Title] Sebaceous carcinoma of the penis.
  • Sebaceous carcinoma is a very aggressive malignant tumor, derived from the adnexal epithelium of sebaceous glands.
  • Extraocular sebaceous carcinoma is a very uncommon neoplasm usually localized on the head and neck.
  • To our knowledge, there are only 2 previously reported cases of sebaceous carcinoma on the penis.
  • We report the clinicopathologic data on 3 additional cases of sebaceous carcinoma arising in the penis.
  • [MeSH-major] Carcinoma. Penile Neoplasms

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19506419.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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36. Leibovitch I, Huilgol SC, Selva D, Lun K, Richards S, Paver R: Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery. J Am Acad Dermatol; 2005 Feb;52(2):295-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is reported to have a high rate of recurrence with standard wide local excision.
  • METHODS: This prospective, multi-center case series included all patients in Australia treated with MMS for MAC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
  • In 32.5% of cases the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Australia / epidemiology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Child. Databases, Factual. Diagnostic Errors. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prospective Studies. Retrospective Studies. Treatment Outcome


37. Thosani MK, Marghoob A, Chen CS: Current progress of immunostains in Mohs micrographic surgery: a review. Dermatol Surg; 2008 Dec;34(12):1621-36
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  • Mohs micrographic surgery is often considered the treatment of choice for a variety of skin malignancies.
  • In recent years, the application of immunostaining techniques has facilitated the successful removal of a number of common and less common cutaneous malignancies, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, dermatofibrosarcoma protuberans, microcystic adnexal carcinoma, sebaceous carcinoma, atypical fibroxanthoma, extramammary Paget's disease, and even sarcomas.
  • [MeSH-major] Mohs Surgery / methods. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Staining and Labeling / methods

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  • (PMID = 19018832.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 127
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38. Hoang MP, Dresser KA, Kapur P, High WA, Mahalingam M: Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol; 2008 Feb;21(2):178-85
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  • [Title] Microcystic adnexal carcinoma: an immunohistochemical reappraisal.
  • Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain.
  • In addition, a comparison with squamous cell carcinoma has not been reported previously.
  • In this study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell carcinoma, and eight squamous cell carcinoma of which five exhibited ductal differentiation.
  • We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative.
  • Forty percent of infiltrative basal cell carcinoma expressed CK7; while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories.
  • While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases.
  • Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10.
  • BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma.
  • In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation.
  • Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15+ and BerEP4+/-; thus, additional studies are needed to separate these two entities.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Skin Appendage / chemistry. Head and Neck Neoplasms / chemistry. Immunohistochemistry / methods. Skin Neoplasms / chemistry
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Humans. Keratin-15 / analysis. Male. Middle Aged


39. Leibovitch I, Huilgol SC, Richards S, Paver R, Selva D: Periocular microcystic adnexal carcinoma: management and outcome with Mohs' micrographic surgery. Ophthalmologica; 2006;220(2):109-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periocular microcystic adnexal carcinoma: management and outcome with Mohs' micrographic surgery.
  • PURPOSE: To report a series of patients with periocular microcystic adnexal carcinoma (MAC) treated with Mohs' micrographic surgery (MMS).
  • METHODS: This series included all patients treated with MMS for periocular MAC, who were monitored by the Skin and Cancer Foundation Australia between 1993 and 2002.
  • The tumor was initially misdiagnosed as basal cell carcinoma in 3 patients and squamous cell carcinoma in 1 patient.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Eyelid Neoplasms / surgery. Mohs Surgery / methods
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 16491033.001).
  • [ISSN] 0030-3755
  • [Journal-full-title] Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
  • [ISO-abbreviation] Ophthalmologica
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Switzerland
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40. Calzavara-Pinton P, Arisi M, Sereni E, Ortel B: A critical reappraisal of off-label indications for topical photodynamic therapy with aminolevulinic acid and methylaminolevulinate. Rev Recent Clin Trials; 2010 May;5(2):112-6
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  • Photodynamic therapy (PDT) with methylaminolevulinate (MAL) has demonstrated high efficacy, minimal side effects, and improved cosmetic outcome in the treatment of its EU-approved clinical indications, i.e. actinic keratoses (AKs), basal cell carcinoma, and Bowen's disease.
  • These findings have expanded the spectrum of possible applications of PDT that now encompasses infectious (viral, bacterial, fungal, protozoal) disorders, epidermal and dermal inflammatory diseases, tumors of lymphocytes, adnexal diseases and premature skin aging due to sun exposure.
  • However, the findings obtained so far must be considered in most off-label indications only preliminary and more detailed studies are required to clarify the role of PDT beyond the treatment of non-melanoma skin cancer.
  • [MeSH-minor] Humans. Rejuvenation. Skin Diseases / drug therapy. Skin Neoplasms / drug therapy

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  • [ErratumIn] Rev Recent Clin Trials. 2010 Sep;5(3):209. Piergiacomo, Calzavara-Pinton [corrected to Calzavara-Pinton, Piergiacomo]; Mariachiara, Arisi [corrected to Arisi, Mariachiara]; Elena, Sereni [corrected to Sereni, Elena]; Bernhard, Ortel [corrected to Ortel, Bernhard]
  • (PMID = 20199385.001).
  • [ISSN] 1876-1038
  • [Journal-full-title] Reviews on recent clinical trials
  • [ISO-abbreviation] Rev Recent Clin Trials
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United Arab Emirates
  • [Chemical-registry-number] 88755TAZ87 / Aminolevulinic Acid
  • [Number-of-references] 52
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41. Nagatsuka H, Rivera RS, Gunduz M, Siar CH, Tamamura R, Mizukawa N, Asaumi J, Nagai N: Microcystic adnexal carcinoma with mandibular bone marrow involvement: a case report with immunohistochemistry. Am J Dermatopathol; 2006 Dec;28(6):518-22
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  • [Title] Microcystic adnexal carcinoma with mandibular bone marrow involvement: a case report with immunohistochemistry.
  • Microcystic adnexal carcinoma is a rare, locally aggressive cutaneous neoplasm with a high probability of persistence locally but a low probability of metastasis.
  • We report a case of a 69-year-old female patient with an indurated plaque at the mental region.
  • Our results indicate that microcystic adnexal carcinoma consists of tumor cells capable of both follicular and eccrine differentiation.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Lip Neoplasms / pathology. Mandibular Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17122497.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / S100 Proteins
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42. Terenzi V, Indrizzi E, Buonaccorsi S, Leonardi A, Pellacchia V, Fini G: Nevus sebaceus of Jadassohn. J Craniofac Surg; 2006 Nov;17(6):1234-9
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  • The nevus sebaceus of Jadassohn (SNJ) is a hamartomatous disorder of the skin and its adnexa pertaining to the group of "organoid nevi,'' most frequently involving the face and scalp.
  • During adulthood, patients with SNJ have a 10% to 20% risk of the development of cutaneous or adnexal neoplasia, so that prophylactic excision before puberty is recommended by most authors, and tissue expansion is considered to be the best method of reconstruction.
  • It has been largely demonstrated in literature that most of the lesions that have been interpreted as basal cell carcinoma (BCC) are actually examples of primitive follicular induction or trichoblastomas, not authentic BCCs.
  • No signs of malignant degeneration or residual pathology have been found.
  • For treatment of the biggest lesions, when preoperative tissue expansion cannot be performed, intraoperative one, transfer of a scalp graft has been shown to be a good reconstructive method.

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  • (PMID = 17119437.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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43. Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R: Squamoid eccrine ductal carcinoma: a case report and review of the literature. Am J Dermatopathol; 2010 May;32(3):287-92
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  • [Title] Squamoid eccrine ductal carcinoma: a case report and review of the literature.
  • Eccrine ductal carcinoma is a rare adnexal tumor.
  • Squamoid eccrine ductal carcinoma (SEDC) represents an exceptionally rare variant with only 6 cases reported to date.
  • This neoplasm is deeply infiltrative and may provide a diagnostic challenge in superficial shave biopsies of skin.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 20010402.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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44. Wu TI, Chang TC, Hsueh S, Lai CH: Ovarian endometrioid carcinoma with diffuse pigmented peritoneal keratin granulomas: a case report and review of the literature. Int J Gynecol Cancer; 2006 Jan-Feb;16(1):426-9
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  • [Title] Ovarian endometrioid carcinoma with diffuse pigmented peritoneal keratin granulomas: a case report and review of the literature.
  • The presence of keratin granulomas in peritoneal cavity associated with ovarian endometrioid carcinoma, which might be related to leakage from the ovarian tumor, is rarely reported.
  • We report a case presenting with intermittent abdominal pain after an acute episode 1 month before a complex adnexal tumor was noted.
  • The patient has been free of disease for 18 months since diagnosis.
  • [MeSH-major] Carcinoma, Endometrioid / secondary. Granuloma / pathology. Lymph Nodes / pathology. Ovarian Neoplasms / pathology. Peritoneal Diseases / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Biopsy, Needle. Female. Flow Cytometry. Follow-Up Studies. Frozen Sections. Humans. Immunohistochemistry. Laparotomy. Middle Aged. Ovariectomy. Treatment Outcome


45. Shah JP, Bryant CS, Kumar S, Ali-Fehmi R, Morris RT: Successful pregnancy after fertility-sparing surgery for peritoneal psammocarcinoma: a case report. J Reprod Med; 2009 Mar;54(3):179-83
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  • BACKGROUND: Psammocarcinoma is a rare form of low grade serous carcinoma of the ovary or peritoneum.
  • CASE: A 27-year-old, nulliparous female presented with an adnexal mass.
  • Pregnancy after the diagnosis and treatment of psammocarcinoma may not alter the clinical course of the disease.

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  • (PMID = 19370904.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, Berkowitz RS, Muto MG, Crum CP: Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol; 2007 Feb;31(2):161-9
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  • [Title] Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship.
  • Proposed origins of pelvic serous carcinoma include the ovary, fallopian tube, and peritoneum.
  • Prophylactic salpingo-oophorectomies in BRCA+ women have recently identified the fimbria as a site of origin for early serous carcinoma (tubal intraepithelial carcinoma or TIC).
  • We explored the relationship of TIC to pelvic serous carcinomas in consecutive cases with complete adnexal exam (SEE-FIM protocol).
  • Of 55 evaluable cases, 41 (75%) were in group A; including tubal (n = 5), peritoneal (n = 6), and ovarian (n = 30) carcinomas.
  • Five of 5 TICs and concurrent ovarian carcinomas contained identical p53 mutations.
  • Thirteen of 14 cases in group B were classified as primary ovarian carcinomas, 10 with features supporting an origin in the ovary.
  • Overall, 71% and 48% of "ovarian" serous carcinomas had endosalpinx involvement or TIC.
  • TIC coexists with all forms of pelvic serous carcinoma and is a plausible origin for many of these tumors.
  • Further studies are needed to elucidate the etiologic significance of TIC in pelvic serous carcinoma, reevaluate the criteria for tubal, peritoneal, and ovarian serous carcinoma, and define the role of the distal tube in pelvic serous carcinogenesis.
  • [MeSH-major] Carcinoma in Situ / pathology. Cystadenocarcinoma, Serous / pathology. Fallopian Tube Neoplasms / pathology. Neoplasms, Second Primary / pathology. Pelvic Neoplasms / pathology

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  • (PMID = 17255760.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA10500
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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47. Moonda A, Fatteh S: Metastatic colorectal carcinoma: an unusual presentation. J Cutan Pathol; 2009 Jan;36(1):64-6
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  • [Title] Metastatic colorectal carcinoma: an unusual presentation.
  • Cutaneous metastases from colorectal carcinomas occur infrequently, usually in the setting of disseminated disease.
  • They most commonly appear on the abdominal wall or perineal area; metastases to other locations of the skin are rare.
  • We describe a case of colorectal signet ring carcinoma with metastasis to the upper lip.
  • To the authors' knowledge, this is the second reported case of colorectal carcinoma with metastasis to the lip and first with signet ring features.
  • Because of the rarity of cutaneous metastases, the primary physician or pathologist may overlook this diagnosis.
  • However, this entity should be considered in the differential diagnosis of adnexal tumors as it may be the initial presentation of the colon carcinoma.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Colorectal Neoplasms / pathology. Lip Neoplasms / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Lymphatic Metastasis / pathology. Male. Sweat Gland Neoplasms / pathology

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  • (PMID = 18715256.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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48. Brown SJ, Lawrence CM: The management of skin malignancy: to what extent should we rely on clinical diagnosis? Br J Dermatol; 2006 Jul;155(1):100-3
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  • [Title] The management of skin malignancy: to what extent should we rely on clinical diagnosis?
  • Clinical diagnosis is an important factor in facilitating the urgent excision of squamous cell carcinomas (SCC) and malignant melanomas.
  • OBJECTIVES: To identify the numbers and types of malignant skin tumours managed in an NHS teaching hospital and to assess the diagnostic accuracy.
  • METHODS: Data were collected on every histologically proven malignant skin lesion over a 6-month period.
  • RESULTS: One thousand one hundred and ninety-five malignant skin tumours were identified: 78% were basal cell carcinomas, 14% were SCC, 6% were malignant melanomas and the remaining 2% included Merkel cell tumours, malignant adnexal tumours and lentigo maligna.
  • The correct clinical diagnosis had been made by the secondary care clinician in 84% of cases but an incorrect clinical diagnosis was given in 32% of SCC.
  • CONCLUSIONS: The majority of skin malignancies (968 of 1195, 81%) were managed by dermatologists.
  • The correct clinical diagnosis was made in 84% of all tumours, but 32% of SCC were not correctly diagnosed prior to surgery.
  • [MeSH-major] Clinical Competence. Dermatology. Patient Selection. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery
  • [MeSH-minor] Biopsy. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Databases, Factual. England. Humans. Melanoma / diagnosis. Melanoma / surgery. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 16792759.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Krahl D, Sellheyer K: Basal cell carcinoma and pilomatrixoma mirror human follicular embryogenesis as reflected by their differential expression patterns of SOX9 and β-catenin. Br J Dermatol; 2010 Jun;162(6):1294-301
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  • [Title] Basal cell carcinoma and pilomatrixoma mirror human follicular embryogenesis as reflected by their differential expression patterns of SOX9 and β-catenin.
  • BACKGROUND: The current classification schemes of adnexal tumours are predominantly based on morphological and immunophenotypical similarities to adult skin structures, whereas a link between the embryology of the skin and the histogenesis of adnexal tumours has been largely neglected.
  • OBJECTIVE: To describe the expression patterns of two proteins with proven relevance for hair follicle homeostasis (SOX9 and β-catenin) during human cutaneous embryogenesis and to compare the findings with their expression in basal cell carcinoma (BCC) and pilomatrixoma.
  • METHODS: Immunohistochemical evaluation with monoclonal antibodies against SOX9 and β-catenin was carried out in embryonic and adult human scalp skin, and BCC and pilomatrixoma samples.
  • CONCLUSIONS:   An appropriate immunophenotyping validated within the conceptual framework of cutaneous developmental biology allows a logical classification of adnexal neoplasms.
  • Expanding this approach further has the potential to revise the current classification schemes so that not only BCC and pilomatrixoma but all adnexal tumours can be categorized logically.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Hair Diseases / metabolism. Hair Follicle / metabolism. Pilomatrixoma / metabolism. SOX9 Transcription Factor / metabolism. Skin Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adult. Humans. Neoplasm Proteins / metabolism. Skin / embryology. Skin / metabolism

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  • [Copyright] © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.
  • (PMID = 20105172.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / beta Catenin
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50. Ozan H, Ozerkan K, Aker S, Bülbül M: A case with three primary tumors of the ovary, endometrium and gallbladder. Eur J Gynaecol Oncol; 2008;29(5):551-3
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  • A 52-year-old patient underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic and paraaortic lymph node dissection, and partial omentectomy for endometrial carcinoma accompanied by an adnexal mass.
  • Histopathology revealed a uterine endometrioid adenocarcinoma, a mucinous adenocarcinoma of the gallbladder, and an ovarian endometrioid carcinoma with a clear cell component.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Endometrioid / pathology. Endometrial Neoplasms / pathology. Gallbladder Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 19051835.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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51. Tornos C, Soslow R, Chen S, Akram M, Hummer AJ, Abu-Rustum N, Norton L, Tan LK: Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Am J Surg Pathol; 2005 Nov;29(11):1482-9
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  • [Title] Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary.
  • Metastatic breast carcinoma to the ovary is sometimes difficult to differentiate from primary ovarian carcinoma.
  • This problem is often encountered in breast carcinoma patients who develop adnexal masses.
  • ER and PR can be positive in a high percentage of breast and ovarian carcinomas, and therefore cannot be used in the differential diagnosis of these entities.
  • However, no studies have been done that specifically compare the immunophenotype of breast carcinoma metastatic to ovary with that of primary ovarian cancer.
  • Thirty-nine cases of metastatic breast carcinoma to the ovary, 36 primary breast carcinomas, and 42 primary ovarian carcinomas were examined immunohistochemically for the expression of WT1, CA125, carcinoembryonic antigen, MUC2, MUC1, and GCDFP.
  • Thirty-two ovarian carcinomas (76%) were positive for WT1, including 31 of 33 (94%) serous carcinomas.
  • Thirty-eight (90%) ovarian carcinomas were positive for CA125, most of them with strong and diffuse staining.
  • Most breast carcinomas were negative for CA125, with only 6 (16%) of the primary ones and 5 (12%) of the metastatic showing weak and focal positivity.
  • All ovarian carcinomas were negative for GCDFP.
  • Nine (21%) ovarian carcinomas, 8 (22%) primary breast carcinomas, and 13 (33%) metastatic to the ovary were positive for carcinoembryonic antigen.
  • Almost all tumors examined were positive for MUC1 (100% ovarian carcinomas, 100% primary breast carcinomas, and 95% metastatic breast carcinomas to ovary).
  • MUC2 was positive in 10 (24%) ovarian carcinomas, 3 (8%) primary breast cancers, and 12 (30%) metastases to the ovary.
  • The presence of immunoreactivity for WT1 and CA125 in a carcinoma involving ovary strongly favors a primary lesion.
  • Most ovarian carcinomas are positive for both markers, whereas the majority of metastatic breast carcinomas to the ovary are negative.
  • GCDFP can be complementary in this differential diagnosis.
  • [MeSH-minor] Antigens / biosynthesis. Antigens, Neoplasm. Carcinoembryonic Antigen / biosynthesis. Diagnosis, Differential. Female. Humans. Mucin-1. Mucin-2. Mucins / biosynthesis


52. Regauer S, Nogales FF: Vulvar trichogenic tumors: a comparative study with vulvar basal cell carcinoma. Am J Surg Pathol; 2005 Apr;29(4):479-84
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  • [Title] Vulvar trichogenic tumors: a comparative study with vulvar basal cell carcinoma.
  • Trichogenic tumors are very rare in genital skin and often cause diagnostic problems because they are mitotically active and they share some histologic features with basal cell carcinomas (BCCs).
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 15767801.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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53. Tellechea O, Reis JP: Trichogerminoma. Am J Dermatopathol; 2009 Jul;31(5):480-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Scalp / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 19542926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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54. Vidal VP, Ortonne N, Schedl A: SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. J Cutan Pathol; 2008 Apr;35(4):373-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms.
  • Activation of the Shh pathway is a major cause of cutaneous basal cell carcinoma (BCC).
  • Here we test whether activation of SOX9 is a general feature of BCC, or whether it could be used as a biomarker to better define subtypes of these skin tumors.
  • In addition we investigated SOX9 expression in other skin epidermal tumors.
  • SOX9 expression was detected in all adnexal tumors analyzed and absent in Bowen's disease and Merkel tumor.
  • CONCLUSIONS: SOX9 expression is a general feature of BCC and adnexal skin neoplasms, suggesting a contribution of SOX9 to the pathogenesis of these tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. High Mobility Group Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Humans. Microscopy, Fluorescence. SOX9 Transcription Factor

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  • (PMID = 18333897.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / High Mobility Group Proteins; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / Transcription Factors
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55. Fan YS, Carr RA, Sanders DS, Smith AP, Lazar AJ, Calonje E: Characteristic Ber-EP4 and EMA expression in sebaceoma is immunohistochemically distinct from basal cell carcinoma. Histopathology; 2007 Jul;51(1):80-6
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  • [Title] Characteristic Ber-EP4 and EMA expression in sebaceoma is immunohistochemically distinct from basal cell carcinoma.
  • AIMS: There is considerable overlap between the histological features of sebaceoma and basal cell carcinoma (BCC).
  • The aim of this study was to describe the immunohistochemical reactivity of the cells in sebaceoma to Ber-EP4 and epithelial membrane antigen (EMA) and investigate the utility of this panel to differentiate sebaceoma from basal cell carcinoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Mucin-1 / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Sebaceous Glands / metabolism. Sebaceous Glands / pathology

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  • (PMID = 17593083.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / human epithelial antigen-125
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56. Mitcov M, Scrivener Y, Cribier B: [Desmoplastic trichoepithelioma: a clinicopathological study, including a comparison with morpheiform basal cell carcinoma]. Ann Dermatol Venereol; 2009 Jun-Jul;136(6-7):501-7
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  • [Title] [Desmoplastic trichoepithelioma: a clinicopathological study, including a comparison with morpheiform basal cell carcinoma].
  • [Transliterated title] Trichoépithéliome desmoplastique : étude anatomoclinique et comparaison avec le carcinome basocellulaire sclérodermiforme.
  • BACKGROUND: Desmoplastic trichoepithelioma (DTE) is an uncommon form of adnexal tumour that was described for the first time as a separate clinicopathological entity in 1976.
  • We carried out a retrospective histopathological study of a large series of cases of DTE in order to better characterise this tumour and compare it with sclerodermiform basal cell carcinoma (BCC), which is in fact the most common as well as the most complex type of differential diagnosis.
  • Diagnosis was confirmed by two different examiners and all microscopic elements were reviewed.
  • The diagnosis was only made by the clinician in four cases; in 38 cases the diagnosis made was BCC.
  • A common finding was granulomas with foreign bodies and calcifications.
  • There is a significant association with naevus, a singular feature among adnexal tumours.
  • A suggested clinical diagnosis is thus possible.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 19560610.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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57. Kim C, Kovich OI, Dosik J: Brooke-Spiegler syndrome. Dermatol Online J; 2007;13(1):10
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  • A 46-year-old woman with Brooke-Spiegler syndrome has multiple cutaneous adnexal neoplasms on her face and scalp.
  • Etiology, clinical features, malignant transformation, and treatment modalities for Brooke-Spiegler syndrome are reviewed.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Face. Female. Humans. Middle Aged. Scalp. Syndrome

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  • (PMID = 17511943.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Ruvalcaba-Limón E, Cantú-de-León D, León-Rodríguez E, Cortés-Esteban P, Serrano-Olvera A, Morales-Vásquez F, Sosa-Sánchez R, Poveda-Velasco A, Crismatt-Zapata A, Santillán-Gómez A, Aguilar-Jiménez C, Alanís-López P, Alfaro-Ramírez P, Alvarez-Avitia MA, Aranda-Flores CE, Arias-Ceballos JH, Arrieta-Rodríguez O, Barragán-Curiel E, Botello-Hernández D, Brom-Valladares R, Cabrera-Galeana PA, Cantón-Romero JC, Capdeville-García D, Cárdenas-Sánchez J, Castorena-Roji G, Cepeda-López FR, Cervantes-Sánchez G, Cetina-Pérez Lde C, Coronel-Martínez JA, Cortés-Cárdenas SA, Cruz-López JC, de la Garza-Salazar JG, Díaz-Romero C, Dueñas-González A, Valle-Solís AE, Escudero-de los Ríos P, Flores-Alvarez E, García-Matus R, Gerson-Cwilich R, González-Enciso A, González-de-León C, Guevara-Torres AG, Herbert-Núñez GS, Hernández-Hernández C, Hernández-Hernández DM, Isla-Ortiz D, Jesús-Sandoval R, Jiménez-Cervantes C, Kuri-Exsome R, López-Obispo JL, Maffuz-Aziz A, Martínez-Barrera LM, Medina-Castro JM, Montalvo-Esquivel G, Mora-Aguilar VH, Morales-Palomares MA, Morán-Mendoza A, Morgan-Villela G, Mota-García A, Muñoz-González DE, Murillo-Cruz DA, Novoa-Vargas A, Ochoa-Carrillo FJ, Oñate-Ocaña LF, Ortega-Rojo A, Palacios-Martínez AG, Palomeque-López A, Pérez-Montiel MD, Quijano-Castro F, Rivera-Rivera S, Rivera-Rubí LM, Robles-Flores JU, Rodríguez-Trejo A, Salas-Gonzáles E, Silva JA, Solorza-Luna G, Souto-del-Bosque R, Tirado-Gómez LL, Torrescano-González S, Torres-Lobatón A, Trejo-Durán E, Villavicencio-Valencia V, Gallardo-Rincón D, Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México: [The first Mexican consensus of endometrial cancer. Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México]. Rev Invest Clin; 2010 Nov-Dec;62(6):583, 585-605
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  • [Title] [The first Mexican consensus of endometrial cancer. Grupo de Investigación en Cáncer de Ovario y Tumores Ginecológicos de México].
  • [Transliterated title] Primer consenso Mexicano de cancer de endometrio.
  • It took place in the context of a meeting of four days in which a debate was held.
  • Diagnosis is made by histerescopy-guided biopsy.
  • Frozen section evaluates histologic grade, myometrial invasion, cervical and adnexal involvement.
  • Total abdominal hysterectomy, bilateral salpingo oophorectomy, pelvic and para-aortic lymphadenectomy should be performed except in endometrial histology grades 1 and 2, less than 50% invasion of the myometrium without evidence of disease out of the uterus.
  • Multidisciplinary treatment impacts on survival and local control of the disease, including surgery, radiation therapy and chemotherapy, hormonal treatment is reserved to selected cases of recurrence.
  • This is the first attempt of a Mexican Collaborative Group in Gynecology to give recommendations is a special type of neoplasm.
  • [MeSH-major] Carcinoma. Endometrial Neoplasms

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  • (PMID = 21416918.001).
  • [ISSN] 0034-8376
  • [Journal-full-title] Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
  • [ISO-abbreviation] Rev. Invest. Clin.
  • [Language] spa
  • [Publication-type] Consensus Development Conference; English Abstract; Journal Article; Practice Guideline
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Estrogen Antagonists; 0 / Estrogens; 094ZI81Y45 / Tamoxifen
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59. Cartaginese F, Sidoni A: Melanocytic matricoma. Report of a further case with clinicopathological and immunohistochemical findings, differential diagnosis and review of the literature. Histol Histopathol; 2010 06;25(6):713-7
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  • [Title] Melanocytic matricoma. Report of a further case with clinicopathological and immunohistochemical findings, differential diagnosis and review of the literature.
  • It usually presents as a pigmented, dark-papular, crusted lesion on sun-damaged skin of adult patients.
  • It differs from matricomas and pilomatricomas by its lack of calcification, cyst formation, granulomas, and connections to the epidermis and other adnexal structures.
  • The clinical differential diagnosis includes hemangioma, pigmented basal cell carcinoma, and melanoma.
  • An extensive search of the medical literature revealed 11 reports of benign melanocytic matricomas and 5 malignant counterparts.
  • We report an additional case of melanocytic matricoma with discussion of clinicopathologic features and differential diagnosis.
  • [MeSH-major] Hair Diseases / pathology. Melanocytes / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Hemangioma / diagnosis. Humans. Immunohistochemistry. Male. Melanoma / diagnosis. Treatment Outcome

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  • (PMID = 20376777.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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60. Fernandez-Flores A: Primary cutaneous apocrine carcinoma versus metastasis, a plea to the dermatopathology community. Am J Dermatopathol; 2010 Dec;32(8):853-4
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  • [Title] Primary cutaneous apocrine carcinoma versus metastasis, a plea to the dermatopathology community.
  • [MeSH-major] Apocrine Glands / pathology. Breast Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Second Primary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Predictive Value of Tests

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  • [CommentOn] Am J Dermatopathol. 2009 May;31(3):278-81 [19384070.001]
  • (PMID = 20431390.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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61. Preuss SF, Stenzel MJ, Hansen T, Eslick GD, Gosepath J: Inverted malignant pilomatricoma of the neck. Eur Arch Otorhinolaryngol; 2005 Apr;262(4):269-71
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  • [Title] Inverted malignant pilomatricoma of the neck.
  • Malignant pilomatricoma is an uncommon malignant follicular adnexal tumor with a predilection for the head and neck among older males.
  • We report the case of a male with an inverted malignant pilomatricoma of the left neck.
  • The initial diagnostics and the treatment pointed to carcinoma of unknown primary (CUP syndrome).
  • However, the preoperative diagnostics did not provide any further information, leading to doubts concerning the initially proposed diagnosis.
  • Histology of the resected tumor revealed a malignant pilomatricoma.
  • [MeSH-major] Hair Diseases / diagnosis. Head and Neck Neoplasms / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • [Cites] Arch Dermatol. 1961 Apr;83:606-18 [13700704.001]
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  • (PMID = 15258812.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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62. Ghosh SK, Bandyopadhyay D, Gupta S, Chatterjee G, Ghosh A: Rapidly growing extraocular sebaceous carcinoma occurring during pregnancy: a case report. Dermatol Online J; 2008;14(8):8
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  • [Title] Rapidly growing extraocular sebaceous carcinoma occurring during pregnancy: a case report.
  • Sebaceous carcinoma is a very rare, aggressive, malignant tumor derived from the adnexal epithelium of sebaceous glands.
  • It is traditionally classified into two groups: tumors arising from the ocular adnexa and those arising in extra-ocular sites.
  • Despite the widespread anatomic distribution of sebaceous glands, extraocular sebaceous carcinoma is very rare, comprising only (1/4) of all reported cases of sebaceous carcinoma.
  • Extraocular sebaceous carcinoma in the post-auricular region or in the external auditory canal is very rarely described in the literature.
  • A case of a rapidly growing sebaceous carcinoma of the pinna occurring in a pregnant woman is reported here for its rarity.
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Pregnancy

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  • (PMID = 19061568.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Battistella M, Mateus C, Lassau N, Chami L, Boukoucha M, Duvillard P, Cribier B, Robert C: Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. J Eur Acad Dermatol Venereol; 2010 Feb;24(2):199-203
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  • [Title] Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma.
  • BACKGROUND: Adnexal carcinomas are rare and diverse cutaneous tumours.
  • Metastatic adnexal carcinomas are very resistant to conventional chemotherapies.
  • Its use in adnexal carcinomas has never been reported.
  • The second patient had a metastatic malignant hair follicle tumour (trichoblastic carcinoma) and achieved a partial remission with sunitinib, and disease stabilized after 10 months.
  • CONCLUSIONS: Sunitinib was effective in controlling the disease in our two patients.
  • [MeSH-major] Acrospiroma / drug therapy. Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Indoles / therapeutic use. Neoplasm Metastasis. Pyrroles / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 19522717.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Indoles; 0 / Pyrroles; 0 / sunitinib
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64. Finger PT: "Finger-tip" cryotherapy probes: treatment of squamous and melanocytic conjunctival neoplasia. Br J Ophthalmol; 2005 Aug;89(8):942-5
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  • AIM: To describe the use of a new spatulated cryoprobe in treatment of conjunctival neoplasia.
  • RESULTS: 12 consecutive patients with malignant conjunctival neoplasia were treated with these new cryotherapy probes.
  • Ophthalmic examinations before and after surgery demonstrated that no acute intraocular or adnexal complications occurred.
  • CONCLUSION: "Finger-tip" cryoprobes were used to treat malignant conjunctival neoplasia (squamous and melanocytic).
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Conjunctival Neoplasms / surgery. Cryosurgery / instrumentation. Melanoma / surgery

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  • (PMID = 16024839.001).
  • [ISSN] 0007-1161
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1772769
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65. Aram S, Moghaddam NA: Bilateral ovarian fibroma associated with Gorlin syndrome. J Res Med Sci; 2009 Jan;14(1):57-61
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  • Gorlin syndrome (GS), also known as nevoid basal cell carcinoma syndrome (NBCCS), is a rare inherited multisystem disorder.
  • Physical examination of genitalia disclosed bilateral adnexal masses.
  • Accurate diagnosis is only possible with close attention to the familial and past medical history and physical examination.

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  • (PMID = 21772861.001).
  • [ISSN] 1735-1995
  • [Journal-full-title] Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
  • [ISO-abbreviation] J Res Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3129069
  • [Keywords] NOTNLM ; Gorlin syndrome / multiple keratocysts / ovarian fibroma
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66. Smith KM, Scase TJ, Miller JL, Donaldson D, Sansom J: Expression of cyclooxygenase-2 by equine ocular and adnexal squamous cell carcinomas. Vet Ophthalmol; 2008 Sep;11 Suppl 1:8-14
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  • [Title] Expression of cyclooxygenase-2 by equine ocular and adnexal squamous cell carcinomas.
  • OBJECTIVE: To investigate whether cyclooxygenase-2 (COX-2) is expressed by equine ocular and adnexal squamous cell carcinomas (SCC).
  • METHODS: Forty-three samples of histologically confirmed cases of ocular SCC or carcinoma in situ (CIS) from 34 horses presented to the Animal Health Trust between 1992 and 2004 were subjected to a standard, two-layered, indirect immunohistochemical method using a rabbit polyclonal antihuman COX-2 antibody.
  • On the basis of this study, it is unlikely that anti-COX-2 therapy would be of benefit in the treatment of equine ocular and adnexal SCC.
  • [MeSH-major] Carcinoma in Situ / veterinary. Carcinoma, Squamous Cell / veterinary. Cyclooxygenase 2 / metabolism. Eye Neoplasms / veterinary. Horse Diseases / enzymology

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  • (PMID = 19046264.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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67. Hascalik S, Celik O, Sarac K, Meydanli MM, Alkan A, Mizrak B: Metabolic changes in pelvic lesions: findings at proton MR spectroscopic imaging. Gynecol Obstet Invest; 2005;60(3):121-7
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  • RESULTS: Spectroscopy analysis of serous, mucinous and undifferentiated carcinoma of the ovary revealed Cho, lactate and lipid signals, but granulosa-theca cell tumor showed only a lipid signal.
  • CONCLUSION: MRS demonstrates significant differences in metabolite concentration between benign and malignant ovarian tumors and pelvic abscesses.
  • MRS may therefore be helpful in the differential diagnosis of adnexal lesions.
  • [MeSH-minor] Abdominal Abscess / metabolism. Abdominal Abscess / pathology. Adult. Aged. Choline / metabolism. Creatine / metabolism. Dermoid Cyst / metabolism. Dermoid Cyst / pathology. Diagnosis, Differential. Endometriosis / metabolism. Endometriosis / pathology. Female. Granular Cell Tumor / metabolism. Granular Cell Tumor / pathology. Humans. Lipid Metabolism. Middle Aged. Neoplasms, Cystic, Mucinous, and Serous / metabolism. Neoplasms, Cystic, Mucinous, and Serous / pathology. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Protons. Teratoma / metabolism. Teratoma / pathology

  • Hazardous Substances Data Bank. CREATINE .
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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15920339.001).
  • [ISSN] 0378-7346
  • [Journal-full-title] Gynecologic and obstetric investigation
  • [ISO-abbreviation] Gynecol. Obstet. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Protons; MU72812GK0 / Creatine; N91BDP6H0X / Choline
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68. Dalton SR, LeBoit PE: Squamous cell carcinoma with clear cells: how often is there evidence of tricholemmal differentiation? Am J Dermatopathol; 2008 Aug;30(4):333-9
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  • [Title] Squamous cell carcinoma with clear cells: how often is there evidence of tricholemmal differentiation?
  • Clear-cell carcinoma of the skin was described by Kuo in 1980 as a cutaneous tumor composed of clear cells that lacked cytoplasmic glycogen or evidence of tricholemmal keratinization.
  • Tricholemmal carcinoma (TC) is conventionally considered to be a neoplasm derived from adnexal keratinocytes with glycogenated clear cells and evidence of outer root sheath or tricholemmal differentiation.
  • The existence of TC has been questioned as it has been argued that without clear immunohistochemical evidence of outer root sheath differentiation, TC cannot be distinguished from clear-cell carcinoma of the skin.
  • Our laboratory has not routinely stained the cases that appear to be carcinomas with clear keratinocytes to determine if glycogen is present and has not made the diagnosis of TC.
  • We sought to test whether the presence of glycogen, light microscopic features said to be typical of TC, or immunohistochemical findings would delineate a group of "true" TC among the cases that we have been recording as squamous cell carcinomas with clear cells (SCC-C).
  • 40 cases of SCC-C were evaluated for 7 histologic and histochemical criteria (a lobular arrangement, peripheral palisading, tricholemmal keratinization, folliculocentricity, evidence of a preexisting tricholemmoma, the presence of intracytoplasmic glycogen, and a thickened basement membrane) said to characterize TC.
  • Overall, the carcinomas showed a spectrum of the above aggregated criteria ranging from 0 to 5.
  • The glycogen-free clear-cell carcinoma described by Kuo seems uncommon in our patient population.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology


69. Lountzis N, Junkins-Hopkins J, Uberti-Benz M, Elenitsas R: Microcystic adnexal carcinoma arising within a nevus sebaceus. Cutis; 2007 Oct;80(4):352-6
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  • [Title] Microcystic adnexal carcinoma arising within a nevus sebaceus.
  • Nevus sebaceus (NS) is a congenital skin lesion arising on the face and scalp that has been linked to the development of various carcinomas.
  • We describe a case of microcystic adnexal carcinoma (MAC) arising in an NS on the scalp of a 62-year-old man.
  • Excisional skin biopsy and hematoxylin and eosin stains were performed to examine the specimen.
  • This case presents a rare finding of MAC within an NS.


70. Deliveliotou A, Hassiakos D, Fotiou S, Karvouni E, Creatsas G: Primary fallopian tube carcinoma associated with ovulation induction; a case report. Int J Gynecol Cancer; 2008 Nov-Dec;18(6):1360-3
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  • [Title] Primary fallopian tube carcinoma associated with ovulation induction; a case report.
  • Primary fallopian tube carcinoma (PFTC) is an uncommon malignancy, not previously associated with fertility drugs use.
  • We describe a case of a 38-year-old woman with primary infertility and a history of three ovulation inductions with gonadotropin-releasing hormone agonist and gonadotrophins, referred for treatment of bilateral ovarian cysts, which were discovered in the beginning of the last cycle.
  • During laparotomy, bilateral adnexal masses were identified, presumed to be of ovarian origin, and total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, and retroperitoneal lymph nodes sampling were performed.
  • Histologic examination showed a primary right fallopian tube endometrioid adenocarcinoma and bilateral adnexal endometriosis.
  • Although evidence of a direct causal link between ovarian stimulation and PFTC does not yet exist, this case highlights the importance for careful evaluation of all discovered adnexal masses in women undergoing ovulation induction treatment.

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  • (PMID = 18217974.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Kacerovska D, Michal M, Kazakov DV: For Valentine's Day: adnexal induction over dermatofibroma. Int J Surg Pathol; 2009 Dec;17(6):452-3
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  • [Title] For Valentine's Day: adnexal induction over dermatofibroma.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Hair Follicle / pathology. Histiocytoma, Benign Fibrous / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Glands / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 19828594.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Kim YH, Lee YK, Choi KW, Lee CY, Kim KH: A Case of Trichilemmal Carcinoma Treated with Mohs Micrographic Surgery. Ann Dermatol; 2008 Sep;20(3):157-61
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  • [Title] A Case of Trichilemmal Carcinoma Treated with Mohs Micrographic Surgery.
  • Trichilemmal carcinoma is a cutaneous adnexal tumor originating from the outer root sheath of hair follicle, and it was first described by Headington in 1976.
  • This neoplasm is a malignant counterpart of trichilemmoma, and it has been reported in the literature as trichilemmal carcinoma, tricholemmal carcinoma, malignant trichilemmoma, and tricholemmocarcinoma.
  • Although histologically, trichilemmal carcinoma frequently has maliganant features, it has a relatively benign clinical behavior.
  • We think Mohs micrographic surgery is a useful treatment modality in trichilemmal carcinoma because the final skin defect is smaller than a wide excision.
  • We report a case of primary trichilemmal carcinoma which had developed on the face, treated with Mohs micrographic surgery.

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  • (PMID = 27303183.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4903970
  • [Keywords] NOTNLM ; Mohs micrographic surgery / Trichilemmal carcinoma
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73. Wetter R, Goldstein GD: Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge. Dermatol Ther; 2008 Nov-Dec;21(6):452-8
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  • [Title] Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
  • Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm that is often diagnosed after having been present for a significant period of time.
  • Actual skin involvement is significantly more extensive than can be determined clinically and because of this, therapy is challenging.
  • Though metastasis is rare, there have been reports of both regional and distant metastatic disease.
  • [MeSH-major] Carcinoma, Skin Appendage / therapy. Skin Neoplasms / therapy

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  • (PMID = 19076623.001).
  • [ISSN] 1529-8019
  • [Journal-full-title] Dermatologic therapy
  • [ISO-abbreviation] Dermatol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 67
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74. Chaudhry IH, Zembowicz A: Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases. Arch Pathol Lab Med; 2007 Nov;131(11):1655-64
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  • [Title] Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases.
  • OBJECTIVE: To describe a previously unrecognized, distinctive cutaneous adnexal carcinoma capable of an aggressive clinical course.
  • DESIGN: Clinicopathologic analysis of a series of 12 cases.
  • Histologically, adnexal clear cell carcinoma with comedonecrosis was characterized by dermal proliferation of nests of epithelial cells showing distinctive zonal arrangement.
  • CONCLUSIONS: Adnexal clear cell carcinoma with comedonecrosis appears to be a distinctive adnexal neoplasm that has to be distinguished from more indolent squamous cell and tricholemmal carcinomas.
  • [MeSH-major] Acne Vulgaris / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoembryonic Antigen / metabolism. Cell Proliferation. Diagnosis, Differential. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Humans. Keratin-17 / metabolism. Male. Middle Aged. Mucin-1 / metabolism. Necrosis / metabolism. Necrosis / pathology

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  • [CommentIn] Arch Pathol Lab Med. 2011 May;135(5):532; author reply 533 [21526948.001]
  • (PMID = 17979483.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-17; 0 / Mucin-1
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75. Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X: Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol; 2007 Feb;31(2):304-10
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  • [Title] Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin.
  • Distinction of primary skin adnexal carcinomas from cutaneous metastasis of adenocarcinomas is challenging.
  • In this study, we evaluated podoplanin immunoreactivity in a series of primary skin adnexal tumors and adenocarcinomas metastatic to skin using a D2-40 antibody.
  • The initial test series were composed of a total of 93 cases including 32 primary skin adnexal carcinomas, 46 benign primary adnexal tumors, and 15 cutaneous metastatic adenocarcinomas.
  • We found that variable D2-40 reactivity was seen in all of the primary cutaneous carcinomas including sebaceous carcinomas (10/10), squamous cell carcinomas (10/10), porocarcinomas (4/4), trichilemmal carcinomas (4/4), skin adnexal carcinomas not otherwise specified (4/4), and in the majority of benign skin adnexal tumors.
  • To confirm the initial findings and to further explore the utility of podoplanin reactivity in the distinction of these tumors, we also examined a test set of 35 unknown cases, including 21 adenocarcinomas metastatic to skin and 14 primary adnexal tumors, in a blinded fashion.
  • Of the 13 D2-40 positive cases, 12 were proven to be primary adnexal tumors.
  • Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%).
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / pathology. Membrane Glycoproteins / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Predictive Value of Tests. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology. Single-Blind Method

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  • (PMID = 17255777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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76. Petersson F, Kutzner H, Spagnolo DV, Bisceglia M, Kacerovska D, Vazmitel M, Michal M, Kazakov DV: Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2009 Oct;31(7):642-8
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  • [Title] Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome.
  • Spiradenoma is a benign, morphologically well-defined cutaneous adnexal neoplasm that is closely related to cylindroma.
  • We present the rare occurrence of adenoid cystic carcinoma (ACC)-like areas in 7 spiradenomas and 1 spiradenocylindroma, not described in the English literature to date.
  • It is concluded that the ACC-like pattern, although a rare feature and of no clinical consequence, is a distinctive finding in a minority of cases and extends the morphological spectrum of spiradenoma and spiradenocylindroma occurring sporadically or in the setting of Brooke-Spiegler syndrome.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Syndrome

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  • (PMID = 19633533.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Redd MA, Bray DW, Royer M: Asymptomatic cutaneous lip plaque. Diagnosis: microcystic adnexal carcinoma (MAC). Arch Dermatol; 2007 Jun;143(6):791-6
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  • [Title] Asymptomatic cutaneous lip plaque. Diagnosis: microcystic adnexal carcinoma (MAC).
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Lip / pathology

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  • (PMID = 17576952.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Huang KH, Chung SD, Huang SY, Chueh SC, Chen CA, Chen J: Coexistence of ovarian cancer and renal cell carcinoma. J Formos Med Assoc; 2007 Mar;106(3 Suppl):S15-9
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  • [Title] Coexistence of ovarian cancer and renal cell carcinoma.
  • Coexistence of ovarian cancer and renal cell carcinoma (RCC) is extremely rare.
  • Computed tomography scan showed a right cystic adnexal mass measuring 10 x 10 cm, and another tumor measuring 3 x 2 cm at the right kidney.
  • Pathologic examination revealed right ovarian clear-cell carcinoma with peritoneal, omental, and fallopian tube metastasis, and conventional clear-cell renal carcinoma.
  • Ovarian clear-cell carcinoma showed weakly positive results in EMA staining and negative results in ER, PR, 34betaE12, and vimentin staining.


79. Prandl EC, Arbab E, Schintler MV, Koch H, Scharnagl E: Microcystic adnexal carcinoma in the nasolabial area: resection and reconstruction with a free fasciocutaneous lateral arm flap with a sandwich technique. Dermatol Surg; 2007 Mar;33(3):378-81
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  • [Title] Microcystic adnexal carcinoma in the nasolabial area: resection and reconstruction with a free fasciocutaneous lateral arm flap with a sandwich technique.

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  • (PMID = 17338702.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Han LY, Landen CN Jr, Kamat AA, Lopez A, Bender DP, Mueller P, Schmandt R, Gershenson DM, Sood AK: Preoperative serum tissue factor levels are an independent prognostic factor in patients with ovarian carcinoma. J Clin Oncol; 2006 Feb 10;24(5):755-61
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  • [Title] Preoperative serum tissue factor levels are an independent prognostic factor in patients with ovarian carcinoma.
  • Using enzyme-linked immunosorbent assay, we assessed preoperative serum TF levels in 98 women with invasive epithelial ovarian carcinoma, 30 with low malignant potential (LMP) tumors, 16 with benign tumors, and a separate validation group of 39 women with adnexal masses.
  • Ovarian cancer patients had a median preoperative serum TF level of 85.2 pg/mL, which was significantly higher than in those with LMP tumors (12.8 pg/mL; P < .01) and benign adnexal disease (30.7 pg/mL; P < .01).
  • Analysis of serum TF levels from the validation set confirmed that high TF (>or=190 pg/mL) was associated with a 3.4-fold increase in risk of death from disease (P = .02) and shorter survival (P = .01).
  • CONCLUSION: Preoperative serum TF levels are significantly elevated in patients with ovarian carcinoma.
  • Elevated preoperative TF level is an independent prognostic factor for death from disease.
  • [MeSH-major] Carcinoma / genetics. Ovarian Neoplasms / genetics. Thromboplastin / analysis. Thromboplastin / biosynthesis

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  • (PMID = 16380413.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1P50CA83639
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9035-58-9 / Thromboplastin
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81. Bulliard C, Murali R, Maloof A, Adams S: Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature. J Cutan Pathol; 2006 Dec;33(12):812-6
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  • [Title] Endocrine mucin-producing sweat gland carcinoma: report of a case and review of the literature.
  • Mucinous carcinoma of skin (MCS) is an uncommon adnexal tumor of disputed differentiation.
  • Here, we report on a case of E-MCS and discuss the differential diagnoses.

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  • (PMID = 17177942.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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82. McCluggage WG: Recent developments in vulvovaginal pathology. Histopathology; 2009 Jan;54(2):156-73
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  • HMGA2 is useful in the diagnosis of aggressive angiomyxoma and its distinction from mimics, in the evaluation of resection margins and in the assessment of the presence or absence of residual disease in re-excisions.
  • Aggressive angiomyxoma is almost invariably positive with oestrogen and progesterone receptors, and there have been several reports of a dramatic reduction in size following gonadotropin releasing hormone agonist therapy.
  • Gastrointestinal stromal tumours have been described as primary neoplasms in the vagina, and rectovaginal septum and extragastrointestinal stromal tumour should be added to the differential diagnosis of a vulvovaginal mesenchymal lesion.
  • There are two corresponding types of vulval squamous carcinoma with HPV-associated and non-HPV-associated variants, the latter often arising in a vulval dystrophy and associated with p53 mutation.
  • However, in some cases there is clinicopathological overlap between HPV-associated and non-HPV-associated squamous carcinomas, and immunohistochemistry with p16 is more reliable than morphology in predicting the presence of HPV.
  • There have been new developments regarding Paget's disease of the vulva with the identification of markers that are useful in diagnosis and evidence that the neoplastic cells represent a proliferation of adnexal stem cells residing in sebaceous units.

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  • (PMID = 18637148.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 138
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83. Hall G, Duncan A, Azurdia R, Leonard N: Lymphoepithelioma-like carcinoma of the skin: a case with lymph node metastases at presentation. Am J Dermatopathol; 2006 Jun;28(3):211-5
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  • [Title] Lymphoepithelioma-like carcinoma of the skin: a case with lymph node metastases at presentation.
  • We report a case of a primary lymphoepithelioma-like carcinoma (LELC) of the skin.
  • He also had axillary node clearance for metastatic disease.
  • Differential diagnoses included squamous cell carcinoma, adnexal carcinoma, Merkel cell tumors, lymphoepithelial lesions, lymphomas, and skin metastases.
  • The histopathologic and immunohistochemical features were those of a LELC of the skin.
  • Just over 30 cases of primary LELCs arising in the skin have been reported with only 1 documented fatality.
  • [MeSH-major] Carcinoma / pathology. Neovascularization, Pathologic / pathology. Rare Diseases / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Merkel Cell / pathology. Diagnosis, Differential. Humans. Lymphatic Metastasis. Lymphoma, B-Cell / pathology. Lymphoma, B-Cell / surgery. Male

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  • (PMID = 16778488.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Jarboe EA, Miron A, Carlson JW, Hirsch MS, Kindelberger D, Mutter GL, Crum CP, Nucci MR: Coexisting intraepithelial serous carcinomas of the endometrium and fallopian tube: frequency and potential significance. Int J Gynecol Pathol; 2009 Jul;28(4):308-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexisting intraepithelial serous carcinomas of the endometrium and fallopian tube: frequency and potential significance.
  • Recently, serous tubal intraepithelial carcinoma (STIC) has been implicated in the pathogenesis of pelvic serous carcinoma.
  • This study explored the potential relationship between STIC and uterine serous carcinoma.
  • Twenty-two consecutive cases of serous carcinoma involving the endometrium were studied.
  • Eleven cases showed concurrent endometrial and adnexal involvement, including 6 with endosalpingeal involvement; STIC was confirmed in 5.
  • This study shows that noninvasive, genetically related serous carcinomas may coexist in both tube and endometrium.
  • As management of serous neoplasms is predicated on site of origin, we propose that the sectioning and extensively examining the fimbria protocol be applied to all endometrial serous carcinomas and that tumors with concurrent STIC be classified as a distinct subset of pelvic serous carcinomas pending a clearer understanding of tumor origin.

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  • [CommentIn] Int J Gynecol Pathol. 2010 May;29(3):278-81 [20407330.001]
  • (PMID = 19483636.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R21CA124688-01A1; United States / NCI NIH HHS / CA / KO8 CA108748; United States / NCI NIH HHS / CA / P50 CA105009
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53; 0 / WTAP protein, human
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85. Alex G: Apocrine adenocarcinoma of the nipple: a case report. Cases J; 2008;1(1):88
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  • Apocrine adenocarcinomas are rare malignant skin adnexal tumours.
  • Apocrine carcinoma of the nipple is extremely rare and this case to the author's knowledge is only the third reported case worldwide and the first with associated ductal carcinoma in situ elsewhere in the breast.
  • A seventy one year old caucasian female presented to the breast clinic with a growth on her nipple which proved on histopathological analysis to be an apocrine carcinoma.
  • Recommended treatment for apocrine carcinoma includes surgery in the form of wide local excision.

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  • [Cites] Dermatol Online J. 2008;14(6):5 [18713586.001]
  • [Cites] Acta Chir Belg. 2004 Aug;104(4):476-8 [15469170.001]
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  • (PMID = 18700029.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2526981
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86. Kelly BC, Koay J, Driscoll MS, Raimer SS, Colome-Grimmer MI: Report of a case: primary mucinous carcinoma of the skin. Dermatol Online J; 2008;14(6):4
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  • [Title] Report of a case: primary mucinous carcinoma of the skin.
  • Primary mucinous carcinoma of the skin is an extremely rare adnexal tumor that is thought to originate from eccrine sweat glands.
  • Since primary mucinous carcinoma of the skin is such a rare neoplasm (fewer than 130 cases have been reported to date), a complete workup should be conducted to rule out other internal malignancies that may metastasize to the skin.
  • We report a case of primary mucinous carcinoma of the skin, and discuss the clinical presentation, histology, treatment, course, and prognosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 18713585.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Krahl D, Sellheyer K: Sox9, more than a marker of the outer root sheath: spatiotemporal expression pattern during human cutaneous embryogenesis. J Cutan Pathol; 2010 Mar;37(3):350-6
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  • It was also characterized as a general marker of basal cell carcinoma.
  • METHODS: We examined immunohistochemically samples from embryonic and fetal human skin for the expression of SOX9 using standard techniques.
  • For comparison reasons, we also included scalp skin from adults.
  • In plantar skin, SOX9 specifically labels the evolving eccrine glands but not the interfollicular keratinocytes.
  • CONCLUSIONS: The distinctive expression pattern of SOX9 during human cutaneous embryogenesis indicates a key role in skin homeostasis that includes but goes beyond its role in outer root sheath differentiation.
  • Studying immunohistochemical markers in developing human skin has the potential to further our understanding of adult skin physiology and to deepen our concepts especially of the histogenesis of adnexal tumors (including those of the nail unit) and the relationship of the various adnexal structures to each other.
  • [MeSH-major] Hair Follicle / embryology. Nails / embryology. SOX9 Transcription Factor / metabolism. Skin / embryology

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  • (PMID = 19614725.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human
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88. Mataix J, Bañuls J, Botella R, Laredo C, Lucas A: [Brooke-Spiegler syndrome: an heterogeneous entity]. Actas Dermosifiliogr; 2006 Dec;97(10):669-72
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  • [Transliterated title] Síndrome de Brooke-Spiegler: una entidad heterogénea.
  • The Brooke-Spiegler syndrome is a rare, autosomally dominant disease with a predisposition to develop different adnexal tumors.
  • In this article we present the case of a woman and her daughter, both affected by this rare genodermatosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Neoplasms, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Adult. Child. Facial Neoplasms / diagnosis. Facial Neoplasms / genetics. Female. Genes, Dominant. Humans. Phenotype

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  • (PMID = 17173833.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 30
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89. Metindir J, Bilir Dilek G: Preoperative hemoglobin and platelet count and poor prognostic factors in patients with endometrial carcinoma. J Cancer Res Clin Oncol; 2009 Jan;135(1):125-9
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  • [Title] Preoperative hemoglobin and platelet count and poor prognostic factors in patients with endometrial carcinoma.
  • METHODS: Sixty-one patients with endometrial carcinoma who underwent surgical treatment consisting of total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, pelvic and para-aortic lymph node dissection, and peritoneal cytology were retrospectively analyzed.
  • Preoperative hemoglobin and platelet count, pelvic and para-aortic lymph node status, depth of myometrial invasion, grade, lymphovascular invasion (LVSI), adnexal involvement, positive peritoneal cytology, cervical stromal invasion, and tumor size were investigated.
  • [MeSH-major] Endometrial Neoplasms / blood. Endometrial Neoplasms / diagnosis. Hemoglobins / metabolism

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  • (PMID = 18542999.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Hemoglobins
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90. Sultana N, Kiyani N: Histopathological features of endometrial carcinoma. J Coll Physicians Surg Pak; 2005 Sep;15(9):539-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological features of endometrial carcinoma.
  • OBJECTIVE: To evaluate and compare the histopathological features of endometrial carcinoma among women of various age groups.
  • PATIENTS AND METHODS: All cases of endometrial carcinoma who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy were included.
  • Vascular invasion, endocervical invasion and adnexal involvement were evident in a small number of cases.
  • Patients (<40 years) had endometrioid type of endometrial carcinoma, grade-1, and FIGO stage-1.
  • CONCLUSION: Patients with endometrial carcinoma presented in early stage (stage-1) and tumor well differentiated (grade-1).
  • In patients of more than 50 years of age even with stage-1, an increased frequency of deep myometrial invasion and less differentiated tumors, adnexal involvement, endocervical invasion, positive peritoneal cytology, vascular invasion and lymph nodes metastasis found.

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  • (PMID = 16181572.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Pakistan
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91. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • [Title] Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation.
  • Brooke-Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Minicozzi A, Leopardi F, Segattini C, Pitoni F, Steccanella F, De Manzoni G, Iannucci A, Governa M: [Perianal Paget's disease: five cases report]. G Chir; 2008 Nov-Dec;29(11-12):469-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Perianal Paget's disease: five cases report].
  • AIM: Extramammary Paget's disease is a rare neoplastic condition, often associated with a synchronous or metachronous underlying skin or visceral malignancies.
  • The aim of this study was to evaluate retrospectively the results we got in 5 cases of perianal Paget's disease and to revise what literature have reported about this issue.
  • In 3 cases the disease was limited to the epidermidis, in one case with multiple recurrences there was dermal infiltration, and one patient had a low rectal adenocarcinoma with pagetoid phenomenon.
  • Four patients are alive and free from disease and one, who developed a multiple local recurrences, died for heart failure.
  • DISCUSSION: The studies available in literature clearly distinguish between a primary EMPD (intraepidermal/intradermal) and secondary disease which is associated with anorectal adenocarcinomas and is thought to be a pagetoid phenomenon, while few informations can derive from those cases in which the disease is associated with an underlying cutaneous adnexal carcinoma.
  • Disease tend to relapse even after a radical surgery and can have metastatic spread, also in intraepidermal form.
  • CONCLUSIONS: Perianal EMPD is a complex disease, difficult to recognize and the association with synchronous or metachronous malignancies imposes long term clinical and instrumental follow up.
  • [MeSH-major] Anus Neoplasms. Paget Disease, Extramammary

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  • (PMID = 19068182.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 40
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93. Tamiolakis D, Venizelos J, Lambropoulou M, Nikolaidou S, Tsikouras P, Jivannakis T, Papadopoulos N: Local immune response in serous papillary carcinoma of the endometrium. Histol Histopathol; 2005 04;20(2):403-8
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  • [Title] Local immune response in serous papillary carcinoma of the endometrium.
  • OBJECTIVE: Serous papillary carcinomas of the endometrium are aggressive tumors that tend to permeate, in a very extensive fashion, to uterine and adnexal lymphatic and vascular channels at an early stage in their evolution, and are associated with a particularly gloomy prognosis.
  • Our aim was to assess the HLA-DR expression in inactive, endometrial intraepithelial carcinoma (EIC), and invasive serous carcinoma curretage specimens from the endometrial cavity, suggesting a role in immune response to keep tumor proliferation in check.
  • STUDY DESIGN: Thirty-one cases of inactive endometrium, twelve cases of EIC, and thirty-nine cases of serous papillary invasive carcinoma curettings were evaluated for the detection of HLA-DR monoclonal antigen.
  • RESULTS: HLA-DR was expressed in 20 of 31 inactive endometrium (64.5%), 4 of 12 in EIC (33.3%), and in 10 of 39 serous papillary invasive carcinomas (25.6%).
  • CD4 was expressed in 9 of 31 inactive endometrium (29%), 5 of 12 in EIC (42%), and in 26 of 39 serous papillary invasive carcinomas (67%).
  • The aberrant expression of HLA-DR by epithelial cells of inactive endometrium, of EIC and of serous papillary invasive carcinomas agrees with the hypothesis of the inactive endometrium - carcinoma in situ sequence as the usual route for the development of serous papillary invasive carcinoma.
  • The immune attract mechanism by low HLA-DR signaling seems to be of minor importance in the malignant and metastatic potential of the serous papillary endometrial tumours.
  • [MeSH-minor] Aged. Antigens, CD4 / metabolism. Carcinoma in Situ / immunology. Carcinoma in Situ / pathology. Female. HLA-DR Antigens / metabolism. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness / immunology. Neoplasm Invasiveness / pathology

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  • (PMID = 15736043.001).
  • [ISSN] 0213-3911
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / HLA-DR Antigens
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94. Campbell RM, Barrall D, Wilkel C, Robinson-Bostom L, Dufresne RG Jr: Post-Mohs micrographic surgical margin tissue evaluation with permanent histopathologic sections. Dermatol Surg; 2005 Jun;31(6):655-8; discussion 658
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  • BACKGROUND: Incomplete resection of nonmelanoma skin cancer is associated with a relatively high rate of recurrent tumors.
  • Mohs micrographic surgery provides microscopic evaluation of tumor margins to ensure complete excision of nonmelanoma skin cancers at high risk of recurrence.
  • OBJECTIVE: This purpose of this study is to confirm the histologic accuracy of Mohs excision of facial skin cancers by evaluating an additional layer of tissue with permanent histopathologic sections after Mohs excision.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Facial Neoplasms / surgery. Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasms, Adnexal and Skin Appendage / surgery. Postoperative Period. Retrospective Studies

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  • [CommentIn] Dermatol Surg. 2006 Mar;32(3):463 [16640701.001]
  • (PMID = 15996415.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Bahrami S, Malone JC, Lear S, Martin AW: CD10 expression in cutaneous adnexal neoplasms and a potential role for differentiating cutaneous metastatic renal cell carcinoma. Arch Pathol Lab Med; 2006 Sep;130(9):1315-9
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  • [Title] CD10 expression in cutaneous adnexal neoplasms and a potential role for differentiating cutaneous metastatic renal cell carcinoma.
  • CONTEXT: Recent investigations have demonstrated the utility of CD10 as a marker for renal cell carcinoma (RCC).
  • Cutaneous metastases occur in up to 11% of patients with RCC and may be the presenting sign of widespread disease.
  • The differential diagnosis in histopathologic evaluation of these cases includes cutaneous adnexal neoplasms, and describing the expression of CD10 in these tumors may be helpful in delineating the differential diagnosis.
  • OBJECTIVE: To determine CD10 expression in a variety of adnexal lesions and to determine the diagnostic utility of CD10 in an immunohistochemical panel differentiating metastatic cutaneous renal cell carcinoma from cutaneous adnexal neoplasms.
  • DESIGN: We studied 57 primary adnexal neoplasms of eccrine (n = 31), apocrine (n = 16), and sebaceous (n = 10) differentiation as well as normal skin (n = 3) and RCC metastatic to the skin (n = 4).
  • CONCLUSION: Based on these results, CD10 is a useful additional immunostain for the discrimination of RCC metastatic to the skin and cutaneous adnexal neoplasms with eccrine and apocrine differentiation, but not with sebaceous differentiation.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neprilysin / analysis. Skin Neoplasms / secondary
  • [MeSH-minor] Antigens, CD / analysis. Apocrine Glands / pathology. Diagnosis, Differential. Eccrine Glands / pathology. Humans. Immunohistochemistry. Sebaceous Glands / pathology. Skin / cytology. Skin / immunology. Skin / pathology

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  • (PMID = 16948517.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; EC 3.4.24.11 / Neprilysin
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96. Kupesic S, Plavsic BM: Early ovarian cancer: 3-D power Doppler. Abdom Imaging; 2006 Sep-Oct;31(5):613-9
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  • Combined evaluations of morphology and neovascularity by 3-D power Doppler ultrasound may improve early detection of ovarian carcinoma.
  • Contrast-enhanced 3-D power Doppler sonography facilitates visualization of adnexal tumor vessels, which may aid in differentiating benign from malignant adnexal lesions.
  • [MeSH-minor] Contrast Media. Early Diagnosis. Female. Humans

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  • (PMID = 16447081.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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97. Schulz T, Proske S, Hartschuh W, Kurzen H, Paul E, Wünsch PH: High-grade trichoblastic carcinoma arising in trichoblastoma: a rare adnexal neoplasm often showing metastatic spread. Am J Dermatopathol; 2005 Feb;27(1):9-16
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  • [Title] High-grade trichoblastic carcinoma arising in trichoblastoma: a rare adnexal neoplasm often showing metastatic spread.
  • It has been debated whether malignant transformation of trichoblastoma occurs.
  • The concept was recently forwarded that basal cell carcinoma is as a malignant neoplasm of follicular germinative cells and should be named trichoblastic carcinoma to show its relationship to trichoblastoma.
  • Almost all basal cell carcinomas are low-grade malignant neoplasms and develop metastases only very rarely, and if so, only after very long duration and untreated growth.
  • Only rare basal cell carcinomas arise in trichoblastomas.
  • Up to now there have only been two reports of high-grade trichoblastic carcinoma arising in trichoblastoma, showing systemic metastatic spread and death.
  • We add two further cases of trichoblastic carcinoma with anaplastic nuclei, arising in trichoblastoma.
  • The other one was a trichoblastic carcinoma at the base of a trichoepithelioma on the right thigh of an 87-year-old woman with Brooke-Spiegler syndrome.
  • Our cases emphasize that high-grade trichoblastic carcinoma develops via malignant transformation of trichoblastoma, and is very rare.
  • [MeSH-major] Carcinoma, Basal Cell / secondary. Carcinoma, Skin Appendage / secondary. Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Second Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 15677970.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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98. Song SH, Lee JK, Saw HS, Choi SY, Koo BH, Kim A, Yeom BW, Kim I: Peutz-Jeghers Syndrome with multiple genital tract tumors and breast cancer: a case report with a review of literatures. J Korean Med Sci; 2006 Aug;21(4):752-7
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  • Pelvic ultrasound showed a multilocular cyst at the right adnexal region, diagnosed as bilateral ovarian mucinous borderline tumors.
  • Although the cases of multiple genital tract tumors with PJS has rarely been reported, the present case appears to be the first in Korea in which the PJS syndrome was complicated by multiple genital tract tumors and infiltrating carcinoma of the breast.
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / pathology. Adult. Carcinoma, Ductal, Breast / complications. Carcinoma, Ductal, Breast / pathology. Endometrium / pathology. Fallopian Tubes / pathology. Female. Humans. Korea. Metaplasia. Sex Cord-Gonadal Stromal Tumors / complications. Sex Cord-Gonadal Stromal Tumors / pathology


99. Yoo SC, Yoon JH, Kim WY, Chang SJ, Joo HJ, Chang KH, Ryu HS: Premenopausal early-stage endometrial carcinoma patients with low CA-125 levels and low tumor grade may undergo ovary-saving surgery. J Gynecol Oncol; 2009 Sep;20(3):181-6
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  • [Title] Premenopausal early-stage endometrial carcinoma patients with low CA-125 levels and low tumor grade may undergo ovary-saving surgery.
  • OBJECTIVE: The purpose of this study was to determine the possible predicting factors of coexisting adnexal malignancies, and to evaluate the safety of ovary-saving surgery for early-stage endometrial carcinoma in premenopausal patients.
  • METHODS: A retrospective review of 107 patients with endometrial carcinoma who underwent surgical treatment at our institution was conducted.
  • RESULTS: Of the 107 patients, 78 patients had stage I to II disease and both preoperative CA-125 levels were measured and tumor grades evaluated.
  • On multivariate analysis, preoperative CA-125 levels (p=0.018) and preoperative tumor grade (p=0.029) were independent predicting factors of adnexal diseases.

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  • (PMID = 19809553.001).
  • [ISSN] 2005-0380
  • [Journal-full-title] Journal of gynecologic oncology
  • [ISO-abbreviation] J Gynecol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2757564
  • [Keywords] NOTNLM ; Endometrial carcinoma / Ovary-saving surgery / Premenopausal women
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100. Fishman DA, Cohen L, Blank SV, Shulman L, Singh D, Bozorgi K, Tamura R, Timor-Tritsch I, Schwartz PE: The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer. Am J Obstet Gynecol; 2005 Apr;192(4):1214-21; discussion 1221-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Epithelial ovarian cancer kills more women than all other gynecologic malignancies combined because of our inability to detect early-stage disease.
  • Increased risk includes women with at least 1 affected first-degree relative with ovarian cancer; a personal history of breast, ovarian, or colon cancer; > or =1 affected first- and second-degree relatives with breast and or ovarian cancer; inheritance of a breast cancer mutation from an affected family member, or membership within a recognized cancer syndrome.
  • A total of 98 women with persistent adnexal masses were identified, and 49 invasive surgical procedures were performed that diagnosed 37 benign ovarian tumors and 12 gynecologic malignancies.
  • All cancers were detected in asymptomatic women who had normal ultrasound and physical examinations 12 and 6 months before the cancer diagnosis.
  • The detected malignancies were fallopian tube carcinoma (stage IIIC; n = 4 women), primary peritoneal carcinoma (n = 4 women; stage IIIA, 1 woman; stage IIIB, 2 women; stage IIIC, 1 woman), epithelial ovarian cancer (stages IIIA and IIIB; n = 2 women), and endometrial adenocarcinoma (stage IA; n = 2 women).
  • Additionally 37 primary and 12 recurrent breast carcinomas were detected by physical examination.
  • A total of 184 women with genetic predisposition (breast cancer positive) have undergone a prophylactic bilateral salpingo-oophorectomy; 23% of these procedures found atypical hyperplasia, and unexpectedly, 2 women (1%) were found to have stage III (A and B) primary peritoneal carcinoma.
  • CONCLUSION: This study demonstrates the limited value of diagnostic ultrasound examination as an independent modality for the detection of early-stage epithelial ovarian cancer in asymptomatic women who are at increased risk for disease.

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  • (PMID = 15846205.001).
  • [ISSN] 0002-9378
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA83639; United States / NCI NIH HHS / CA / R01 CA01015; United States / NCI NIH HHS / CA / R01 CA82562; United States / NCI NIH HHS / CA / R01 CA89503; United States / NCI NIH HHS / CA / UO1CA85133
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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