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1. Abbas O, Mahalingam M: Tumor of the follicular infundibulum: an epidermal reaction pattern? Am J Dermatopathol; 2009 Oct;31(7):626-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor of the follicular infundibulum: an epidermal reaction pattern?
  • Our recent experience indicates that the desmoplastic variant of tumor of the follicular infundibulum (TFI) is not, as previously believed, entirely uncommon.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19633534.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Kazakov DV, Mentzel T, Erlandson RA, Mukensnabl P, Michal M: Clear cell trichoblastoma: a clinicopathological and ultrastructural study of two cases. Am J Dermatopathol; 2006 Jun;28(3):197-201
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  • [MeSH-major] Carcinoma, Basal Cell / ultrastructure. Head and Neck Neoplasms / ultrastructure. Neoplasms, Adnexal and Skin Appendage / ultrastructure. Skin Neoplasms / ultrastructure

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  • (PMID = 16778484.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Köstler E, Schönlebe J, Mentzel T, Haroske G, Wollina U: Psoriasis and Brooke-Spiegler syndrome with multiple malignancies. J Eur Acad Dermatol Venereol; 2005 May;19(3):380-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / complications. Parotid Neoplasms / pathology. Psoriasis / etiology. Skin Neoplasms / pathology


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4. Kazakov DV, Kutzner H, Rütten A, Mukensnabl P, Michal M: Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol; 2005 Jun;27(3):195-203
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  • [Title] Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma.
  • This report emphasizes a carcinoid-like pattern, a previously unrecognized feature in cutaneous sebaceous neoplasms.
  • Although the neoplasm appeared benign architecturally, the presence of cytologic atypia qualified 2 tumors as low-grade carcinomas.
  • We conclude that the carcinoid-like pattern is another distinctive pattern indicative of sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Biomarkers, Tumor / analysis. Carcinoid Tumor / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Diagnosis, Differential. Female. History, 16th Century. Humans. Immunohistochemistry. Inclusion Bodies / pathology. Male. Microscopy, Electron, Transmission. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrastructure. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 15900121.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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5. Ostler DA, Prieto VG, Reed JA, Deavers MT, Lazar AJ, Ivan D: Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol; 2010 Apr;23(4):567-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / analysis. Peptides / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Membrane Proteins. Middle Aged. Neoplasms, Adnexal and Skin Appendage / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Young Adult

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  • (PMID = 20118912.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / Peptides; 0 / perilipin 2
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6. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10
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  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16-year period.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • RESULTS: Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period.
  • Only two cases had a clinical diagnosis of adnexal tumor.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • Malignant adnexal tumors are uncommon in our setting.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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7. Kang TW, Kang H, Kim HO, Song KY, Park YM: Trichoblastoma in a child. Pediatr Dermatol; 2009 Jul-Aug;26(4):476-7
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  • A trichoblastoma is a benign adnexal neoplasm composed of follicular germinative cells.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 19689532.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Adamicová K, Fetisovová Z, Mellová Y, Výbohová D: [Diagnostic procedures in skin adnexal tumours]. Cesk Patol; 2006 Apr;42(2):59-65
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  • [Title] [Diagnostic procedures in skin adnexal tumours].
  • From histogenetic, morphologic and immunohistochemical point of view the authors try to make possible algorithms that can be employed in a routine diagnosis of adnexal skin tumours.
  • They stress the importance of knowledge of clinical data necessary for orientation classification of tumour skin lesions after biopsies.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis

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  • (PMID = 16715628.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 33
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9. Liang H, Wu H, Giorgadze TA, Sariya D, Bellucci KS, Veerappan R, Liegl B, Acs G, Elenitsas R, Shukla S, Youngberg GA, Coogan PS, Pasha T, Zhang PJ, Xu X: Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol; 2007 Feb;31(2):304-10
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  • [Title] Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin.
  • Distinction of primary skin adnexal carcinomas from cutaneous metastasis of adenocarcinomas is challenging.
  • In this study, we evaluated podoplanin immunoreactivity in a series of primary skin adnexal tumors and adenocarcinomas metastatic to skin using a D2-40 antibody.
  • The initial test series were composed of a total of 93 cases including 32 primary skin adnexal carcinomas, 46 benign primary adnexal tumors, and 15 cutaneous metastatic adenocarcinomas.
  • We found that variable D2-40 reactivity was seen in all of the primary cutaneous carcinomas including sebaceous carcinomas (10/10), squamous cell carcinomas (10/10), porocarcinomas (4/4), trichilemmal carcinomas (4/4), skin adnexal carcinomas not otherwise specified (4/4), and in the majority of benign skin adnexal tumors.
  • To confirm the initial findings and to further explore the utility of podoplanin reactivity in the distinction of these tumors, we also examined a test set of 35 unknown cases, including 21 adenocarcinomas metastatic to skin and 14 primary adnexal tumors, in a blinded fashion.
  • Of the 13 D2-40 positive cases, 12 were proven to be primary adnexal tumors.
  • Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%).
  • [MeSH-major] Adenocarcinoma / secondary. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / pathology. Membrane Glycoproteins / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Predictive Value of Tests. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology. Single-Blind Method

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  • (PMID = 17255777.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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10. Tellechea O, Reis JP: Trichogerminoma. Am J Dermatopathol; 2009 Jul;31(5):480-3
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  • A case of distinctive benign follicular neoplasm previously reported under the designation of trichogerminoma is described.
  • This neoplasm and the other tumors with hair germ differentiation such as trichoblastoma and panfolliculoma seem to represent the same spectrum of hair follicle neoplasms only distinguishable by their degree of differentiation.
  • [MeSH-major] Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Scalp / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Skin Neoplasms / pathology

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  • (PMID = 19542926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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11. Kato K, Uchida K, Nibe K, Tateyama S: Immunohistochemical studies on cytokeratin 8 and 18 expressions in canine cutaneous adnexus and their tumors. J Vet Med Sci; 2007 Mar;69(3):233-9
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  • The expressions of cytokeratin 8 and 18 (CK8 and CK18) in the normal canine skin (2 cases) and cutaneous adnexal tumors (127 cases) were investigated immunohistochemically.
  • In the normal skin, co-expression of CK8/18 was found in the glandular epithelium of apocrine sweat glands, and single CK8-immunoreactivity was detected occasionally in the external root sheath at the isthmus and suprabulbar regions of the hair follicles.
  • In several cases of trichoblastomas (4/28 cases, 14%) and trichoepitheliomas (2/19 cases, 11%), tumor cells forming glandular structures had co-expression of CK8/18.
  • Thus, the combination of CK8- and 18-immunostainings may have the utility to confirm the directions of differentiation in canine cutaneous adnexal tumors providing a reliable hallmark for histopathological diagnoses.

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  • (PMID = 17409637.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Keratin-8
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12. González-Guerra E, Requena L, Kutzner H: [Immunohistochemical study of calretinin in normal hair follicles and tumors with follicular differentiation]. Actas Dermosifiliogr; 2008 Jul-Aug;99(6):456-63
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  • [Transliterated title] Estudio inmunohistoquímico de la calretinina en el folículo piloso normal y neoplasias con diferenciación folicular.
  • OBJECTIVE: The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.
  • MATERIAL AND METHODS: We analyzed the staining pattern for calretinin by immunohistochemistry in 49 biopsies of cutaneous adnexal tumors with follicular differentiation.
  • CONCLUSION: Immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors of the hair follicle or a component of the follicle with differentiation towards cells of the outer root sheath.
  • [MeSH-major] Hair Follicle / chemistry. Neoplasm Proteins / analysis. S100 Calcium Binding Protein G / analysis. Skin Neoplasms / chemistry
  • [MeSH-minor] Acanthoma / chemistry. Acanthoma / pathology. Calbindin 2. Carcinoma, Basal Cell / chemistry. Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / chemistry. Carcinoma, Skin Appendage / pathology. Cell Differentiation. Epidermal Cyst / metabolism. Epidermal Cyst / pathology. Hamartoma / metabolism. Hamartoma / pathology. Humans. Neoplasms, Basal Cell / chemistry. Neoplasms, Basal Cell / pathology. Skin Diseases / metabolism. Skin Diseases / pathology

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  • (PMID = 18558053.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G
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13. Tirumalae R, Böer A: Calcification and ossification in eccrine mixed tumors: underrecognized feature and diagnostic pitfall. Am J Dermatopathol; 2009 Dec;31(8):772-7
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  • BACKGROUND: Eccrine mixed tumors of the skin are rare adnexal neoplasms, and their morphological spectrum is not well established.
  • METHODS: Among 70, 000 skin biopsies, 5 were diagnosed as eccrine mixed tumors.
  • The stroma was mucinous and chondroid, calcification ranging from little to extensive with bone formation in 3 examples giving the impression of a chondroid or osseous neoplasm.
  • [MeSH-major] Eccrine Glands / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Calcinosis. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 19730221.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Kishida ES, Muniz Silva MA, da Costa Pereira F, Sanches JA Jr, Sotto MN: Epidermal nevus syndrome associated with adnexal tumors, spitz nevus, and hypophosphatemic vitamin D-resistant rickets. Pediatr Dermatol; 2005 Jan-Feb;22(1):48-54
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  • [Title] Epidermal nevus syndrome associated with adnexal tumors, spitz nevus, and hypophosphatemic vitamin D-resistant rickets.
  • We present a patient with epidermal nevus syndrome associated with hypophosphatemic vitamin D-resistant rickets and multiple adnexal and spindle cell tumors.
  • [MeSH-major] Hypophosphatemia, Familial / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Epithelioid and Spindle Cell / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Child. Female. Humans. Hypophosphatemia / metabolism. Nevus. Nevus, Pigmented. Skin. Syndrome


15. Nelson PS, Bourgeois KM, Nicotri T Jr, Chiu ES, Poole JC: Sclerosing sweat duct carcinoma in a 6-year-old African American child. Pediatr Dermatol; 2008 Jan-Feb;25(1):38-42
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  • Sclerosing sweat duct carcinoma is a rare, locally aggressive adnexal tumor that frequently occurs on the face of middle-aged adults, invades deeply, and has a propensity to recur.
  • We report a rare instance of sclerosing sweat duct carcinoma occurring in a 6-year-old African American child and review the literature of this infrequently observed neoplasm.
  • [MeSH-major] African Americans. Carcinoma, Skin Appendage / ethnology. Carcinoma, Skin Appendage / pathology. Neoplasm Invasiveness / pathology. Sweat Gland Neoplasms / ethnology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18304151.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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16. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • Brooke-Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • Many lesions had hybrid features of two or more neoplasms.
  • By far the most common composite tumor was spiradenocylindroma.
  • The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Retamar RA, Stengel F, Saadi ME, Kien MC, Della Giovana P, Cabrera H, Chouela EN: Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser. Int J Dermatol; 2007 Jun;46(6):583-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Carcinoma, Adenoid Cystic / surgery. Laser Therapy. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms / surgery

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  • (PMID = 17550556.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Kim DS, Kim DY, Kwon YS, Chung KY: Childhood [corrected] onset lymphadenoma [corrected]. Pediatr Dermatol; 2008 May-Jun;25(3):413-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • [ErratumIn] Pediatr Dermatol. 2008 Jul-Aug;25(4):507
  • (PMID = 18577068.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD
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19. Le Hémon A, Nuccio A, Thiéry G, Coulet O, de Biasi C, Cribier B, Morand JJ: [Trichoblastic carcinoma on the lip]. Ann Dermatol Venereol; 2010 Oct;137(10):669-71
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  • [Transliterated title] Carcinome trichoblastique de la lèvre.
  • [MeSH-major] Hair Follicle. Lip Neoplasms / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis
  • [MeSH-minor] Aged. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Dermatologic Surgical Procedures. Diagnosis, Differential. Humans. Lymphatic Metastasis / pathology. Male. Neoplasm Invasiveness. Radiotherapy, Adjuvant. Skin / pathology. Surgical Flaps

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  • (PMID = 20932455.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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20. Yu JB, Blitzblau RC, Patel SC, Decker RH, Wilson LD: Surveillance, Epidemiology, and End Results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skin. Am J Clin Oncol; 2010 Apr;33(2):125-7
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  • [Title] Surveillance, Epidemiology, and End Results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skin.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is a very rare cancer of the skin.
  • Predominant site of disease was the head and neck skin (74%).
  • There was only 1 case of recorded metastatic disease.
  • [MeSH-major] Carcinoma, Ductal / pathology. Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Clin Oncol. 2010 Apr;33(2):196-7 [20375780.001]
  • (PMID = 19675445.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Suwattee P, McClelland MC, Huiras EE, Warshaw EM, Lee PK, Kaye VN, McCalmont TH, Niehans GA: Plaque-type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma. J Cutan Pathol; 2008 Jun;35(6):570-4
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  • [Title] Plaque-type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma.
  • This benign neoplasm may be easily misdiagnosed as microcystic adnexal carcinoma (MAC), potentially resulting in unnecessary surgery with disfiguring consequences.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Cysts / pathology. Diagnostic Errors. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis. Syringoma / diagnosis


22. Ntomouchtsis A, Vahtsevanos K, Patrikidou A, Andreadis C, Tsobanidou C, Antoniades K: Adnexal skin carcinomas of the face. J Craniofac Surg; 2009 Jan;20(1):134-7
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  • [Title] Adnexal skin carcinomas of the face.
  • Skin adnexal neoplasms are rare tumors, and knowledge on their exact histological development and pathogenesis remains fragmented.
  • Records of patients with histologically confirmed adnexal skin carcinoma managed at a single department during the period 1995 to 2004 were reviewed.
  • Patient biodata, surgical management, and main outcome measures such as locoregional recurrence, distant metastasis, and disease-free and overall survival were recorded.Eleven patients were identified from record analysis.
  • Nine of 11 patients were alive and free of local and/or regional disease on final follow-up.
  • Two patients died of causes unrelated to the disease.
  • Clinical and histological features, tumor biological behavior, diagnostic difficulties, and recommended management are discussed.In conclusion, adnexal skin tumors should be considered in the differential diagnosis of skin tumors, particularly in view of their more sinister prognosis compared with other nonmelanoma skin tumors.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Facial Neoplasms / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Cohort Studies. Diagnosis, Differential. Disease-Free Survival. Eyelid Neoplasms / surgery. Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local / pathology. Neoplasms, Second Primary / pathology. Nose Neoplasms / surgery. Retrospective Studies. Surgical Flaps. Survival Rate. Treatment Outcome

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  • (PMID = 19165010.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Pozo L, Diaz-Cano SJ: Trichogerminoma: further evidence to support a specific follicular neoplasm. Histopathology; 2005 Jan;46(1):108-10
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  • [Title] Trichogerminoma: further evidence to support a specific follicular neoplasm.
  • [MeSH-major] Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 15656895.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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24. McCalmont TH: Batman and adnexal tumors. J Cutan Pathol; 2010 Apr;37(4):401-2
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  • [Title] Batman and adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • [CommentIn] J Cutan Pathol. 2010 May;37(5):513-5 [20447265.001]
  • (PMID = 20377669.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] Denmark
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25. van Trappen PO, Rufford BD, Mills TD, Sohaib SA, Webb JA, Sahdev A, Carroll MJ, Britton KE, Reznek RH, Jacobs IJ: Differential diagnosis of adnexal masses: risk of malignancy index, ultrasonography, magnetic resonance imaging, and radioimmunoscintigraphy. Int J Gynecol Cancer; 2007 Jan-Feb;17(1):61-7
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  • [Title] Differential diagnosis of adnexal masses: risk of malignancy index, ultrasonography, magnetic resonance imaging, and radioimmunoscintigraphy.
  • A risk of malignancy index (RMI), based on menopausal status, ultrasound (US) findings, and serum CA125, has previously been described and validated in the primary evaluation of women with adnexal masses and is widely used in selective referral of women from local cancer units to specialized cancer centers.
  • Additional imaging modalities could be useful for further characterization of adnexal masses in this group of women.
  • A prospective cohort study was conducted of 196 women with an adnexal mass referred to a teaching hospital for diagnosis and management.
  • Follow-up data was obtained for 180 women; 119 women had benign and 61 women malignant adnexal masses.
  • We identified a subgroup of women with RMI values of 25-1000 where the value of further specialist imaging was evaluated.
  • Using this RMI cutoff followed by specialist US and MRI, as opposed to the traditional RMI cutoff value of 250, can increase the proportion of patients with cancer appropriately referred in to a cancer center, with no change in the proportion of patients with benign disease being managed in a local unit.
  • [MeSH-major] Genital Diseases, Female / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis
  • [MeSH-minor] Adnexa Uteri / pathology. Adnexa Uteri / ultrasonography. Adolescent. Adult. Aged. Aged, 80 and over. Cohort Studies. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Prospective Studies. Risk Factors. Sensitivity and Specificity

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  • (PMID = 17291233.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Malhotra P, Singh A, Ramesh V: Syringocystadenoma papilliferum on the thigh: an unusual location. Indian J Dermatol Venereol Leprol; 2009 Mar-Apr;75(2):170-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19293506.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 15
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27. Morris-Jones R, Creamer D, Selim A: A clinically challenging pigmented lesion on the scalp. Clin Exp Dermatol; 2010 Jun;35(4):e196-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis. Scalp. Skin Neoplasms / diagnosis

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  • (PMID = 20518914.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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28. Riou-Gotta MO, Fournier E, Danzon A, Pelletier F, Levang J, Mermet I, Blanc D, Humbert P, Aubin F: Rare skin cancer: a population-based cancer registry descriptive study of 151 consecutive cases diagnosed between 1980 and 2004. Acta Oncol; 2009;48(4):605-9
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  • [Title] Rare skin cancer: a population-based cancer registry descriptive study of 151 consecutive cases diagnosed between 1980 and 2004.
  • BACKGROUND: There are few epidemiological data available on rare skin cancer, including Merkel cell carcinoma, Paget's disease, adnexal carcinoma, and sarcoma.
  • We conducted this study to investigate the epidemiology of rare skin cancer diagnosed in the department of Doubs from 1980 to 2004.
  • Median age for the diagnosed disease was 63 years.
  • Fifty nine cases (39%) were sarcomas, 35 (23%) adnexal carcinomas, 27 (18%) Merkel cell carcinoma and 27 (18%) Paget's disease.
  • The standardized incidence rates were 0.37/100 000 (0.27-0.47) for sarcomas, 0.16 (0.10-0.22) for adnexal tumors, 0.13 (0.08-0.18) for Merkel cell carcinoma, and 0.15 (0.09-0.21) for Paget's disease.
  • CONCLUSIONS: Our results based on a population-based cancer registry showed an increase of the standardized incidence rate for all types of rare skin tumors.
  • [MeSH-major] Skin Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Merkel Cell / epidemiology. Child. Female. France / epidemiology. Histiocytoma, Malignant Fibrous / epidemiology. Humans. Incidence. Male. Middle Aged. Neoplasms, Adnexal and Skin Appendage / epidemiology. Rare Diseases / epidemiology. Registries. Retrospective Studies. Sarcoma / epidemiology. Young Adult

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  • (PMID = 19137462.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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29. Gauerke S, Driscoll JJ: Hidradenocarcinomas: a brief review and future directions. Arch Pathol Lab Med; 2010 May;134(5):781-5
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  • Hidradenocarcinomas are rare, aggressive skin adnexal tumors of sweat gland origin that demonstrate a high potential for local recurrence, metastasis, and poor outcome.
  • These neoplasms can derive from preexisting clear cell hidradenomas but more commonly appear de novo, with the molecular events responsible for the pathogenesis currently unknown.
  • Historically, diagnosis has been difficult because of the few cases, inconsistent nomenclature, variable morphology of cells that compose the neoplasm, and confusion with other visceral metastatic tumors.
  • Despite wide-excision surgery, disease at regional lymph nodes and metastatic sites is common and linked to decreased survival.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Diagnosis, Differential. Humans. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 20441512.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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30. Qureshi YA, Karp CL, Dubovy SR: Intralesional interferon alpha-2b therapy for adnexal Kaposi sarcoma. Cornea; 2009 Sep;28(8):941-3
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  • [Title] Intralesional interferon alpha-2b therapy for adnexal Kaposi sarcoma.
  • PURPOSE: To describe a case of adnexal Kaposi's sarcoma successfully treated with intralesional interferon alpha 2b injections.
  • This resulted in a dramatic reduction in tumor burden and lid edema, an improvement in lid position, and corneal healing.
  • CONCLUSION: Ocular adnexal and conjunctival Kaposi's sarcoma was successfully treated with 3 adjuvant intralesional interferon alpha-2b injections leading to a dramatic decrease in tumor mass.
  • [MeSH-major] Antiviral Agents / administration & dosage. Conjunctival Neoplasms / drug therapy. Eyelid Neoplasms / drug therapy. Interferon-alpha / administration & dosage. Neoplasms, Adnexal and Skin Appendage / drug therapy. Sarcoma, Kaposi / drug therapy
  • [MeSH-minor] Adult. Disease Progression. Edema / etiology. Entropion / etiology. Entropion / pathology. Eyelashes. Eyelid Diseases / etiology. Hair Diseases / etiology. Humans. Injections, Intralesional. Male. Recombinant Proteins. Treatment Outcome

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  • (PMID = 19654515.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 99210-65-8 / interferon alfa-2b
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31. Krahl D, Sellheyer K: Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma. J Cutan Pathol; 2007 Oct;34(10):782-7
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  • [Title] Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma.
  • BACKGROUND: Sclerosing cutaneous neoplasms often represent a diagnostic challenge.
  • In this study, we report its application in the differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and basal cell carcinoma.
  • METHODS: Biopsy samples from 28 sclerosing and infiltrating basal cell carcinomas, 13 microcystic adnexal carcinomas and 16 desmoplastic trichoepitheliomas were examined after immunohistochemical staining with Ber-EP4.
  • RESULTS: Ber-EP4 did not label any of the microcystic adnexal carcinomas, whereas all 28 basal cell carcinomas were Ber-EP4 positive.
  • CONCLUSIONS: Ber-EP4 reliably differentiates microcystic adnexal carcinoma from basal cell carcinoma to the same extent as it distinguishes the latter tumor from squamous cell carcinoma.
  • While it stains the majority of desmoplastic trichoepitheliomas, these tumors still have to be considered in the differential diagnosis with microcystic adnexal carcinoma, when Ber-EP4 is applied.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / diagnosis. Carcinoma, Skin Appendage / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis


32. Brandt SM, Swistel AJ, Rosen PP: Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl. Am J Surg Pathol; 2009 Jun;33(6):950-3
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  • [Title] Secretory carcinoma in the axilla: probable origin from axillary skin appendage glands in a young girl.
  • Invasive carcinoma in the axilla may arise from skin appendage glands or ectopic breast tissue or it may be a metastasis.
  • Carcinomas of the skin adnexal glands and breast can be difficult to distinguish from each other as they often display the same patterns of growth.
  • Tubular, cribriform, papillary, apocrine, mucinous, and adenoid cystic are histologic types of carcinoma seen in the breast and skin appendage glands.
  • To our knowledge, secretory carcinoma, the most common form of mammary carcinoma in children, has not yet been described as a morphologic pattern of skin adnexal carcinoma, although we cannot exclude the possibility that such a case was reported with a different diagnosis.
  • We report a case of a young girl with secretory carcinoma that seems to have arisen from skin appendage glands in the skin of the axilla in the absence of demonstrable ectopic breast tissue.
  • [MeSH-major] Axilla / pathology. Carcinoma, Skin Appendage / pathology. Skin Neoplasms / pathology

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  • [CommentIn] Am J Surg Pathol. 2010 Aug;34(8):1226-7; author reply 1228 [20631609.001]
  • (PMID = 19342945.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Clement CI, Genge J, O'Donnell BA, Lochhead AG: Orbital and periorbital microcystic adnexal carcinoma. Ophthal Plast Reconstr Surg; 2005 Mar;21(2):97-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orbital and periorbital microcystic adnexal carcinoma.
  • PURPOSE: To review the clinical and histopathologic features of patients with microcystic adnexal carcinoma of the orbital and periorbital tissues.
  • All had initial histopathology diagnosed as squamous cell carcinoma but were subsequently diagnosed as microcystic adnexal carcinoma after clinical recurrence.
  • CONCLUSIONS: Review of the literature shows that microcystic adnexal carcinoma affecting the orbital and periorbital tissues is difficult to differentiate clinically and microscopically from other conditions including squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Eyelid Neoplasms / pathology. Orbital Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 15778661.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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34. Chiarelli S, Padoan I, Parenti A, Ninfo V, D'Andrea E: Pathologic findings in 200 consecutive fallopian tube specimens. Hum Pathol; 2009 Apr;40(4):603-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Fallopian Tube Neoplasms / epidemiology. Fallopian Tube Neoplasms / pathology. Fallopian Tubes / pathology
  • [MeSH-minor] Female. Genetic Predisposition to Disease. Humans. Middle Aged. Neoplasms, Adnexal and Skin Appendage / pathology

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  • [CommentOn] Hum Pathol. 2007 Aug;38(8):1160-3 [17270244.001]
  • (PMID = 19289185.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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35. Patrizi A, Gaspari V, Bianchi F, Misciali C, Neri I: Congenital nodular lesion of the anterior thorax in a child. Clin Exp Dermatol; 2008 Mar;33(2):223-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Polyps / pathology

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  • (PMID = 18257844.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Vidal CI, Goldberg M, Burstein DE, Emanuel HJ, Emanuel PO: p63 Immunohistochemistry is a useful adjunct in distinguishing sclerosing cutaneous tumors. Am J Dermatopathol; 2010 May;32(3):257-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cutaneous sclerosing epithelial neoplasms are often difficult to diagnose.
  • We aimed to assess the utility of p63 immunohistochemical staining in distinguishing microcystic adnexal carcinoma (MAC) from sclerosing basal cell carcinoma (SBCC) and desmoplastic trichoepithelioma (DTE).
  • Although all adnexal tumors examined demonstrated p63 expression, the pattern of staining was strikingly different in MAC when compared with other tumor types.
  • MAC exhibited a scattered pattern with p63-positive cells around the periphery of tumor nests and minimal staining within the center of the tumor islands.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Carcinoma, Skin Appendage / diagnosis. Skin Neoplasms / diagnosis. Trans-Activators / analysis. Tumor Suppressor Proteins / analysis


37. Czekierdowski A, Stachowicz N, Smoleń A, Kotarski J: [The use of 2-dimensional and 3-dimensional color and power-Doppler in the diagnosis of blood flow indices of adnexal tumors]. Ginekol Pol; 2006 Apr;77(4):296-306
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  • [Title] [The use of 2-dimensional and 3-dimensional color and power-Doppler in the diagnosis of blood flow indices of adnexal tumors].
  • OBJECTIVES: The purpose of this study was to compare 2-dimensional and 3-dimensional color and power-Doppler as measured with blood flow indices for the prediction of malignancy in complex adnexal masses.
  • METHODS: Two hundred eighty women with complex adnexal masses (mean age, 46,3 years (range, 13-83 years) were evaluated by 2-dimensional and 3-dimensional power-Doppler imaging.
  • Complex adnexal mass was defined as the presence of at least one of the following features: solid areas, thick papillary projections, thick septa, or purely solid echogenicity.
  • Tumor volume, sonomorphology and Doppler indices (PI, RI), as well 3-dimensional power-Doppler assessment (VI, FI, VFI) were calculated.
  • However, the highest sensitivity of 3D indices for malignant tumor detection was found for FI (42.9%).
  • CONCLUSION: Three-dimensional power-Doppler imaging has diagnostic potential for the discrimination of benign and malignant complex adnexal masses, but specific, possibly most vascularised areas of each tumor have to be examined in detail to improve not yet satisfactory predictive values of this method.
  • [MeSH-major] Genital Neoplasms, Female / ultrastructure. Imaging, Three-Dimensional. Neoplasms, Adnexal and Skin Appendage / diagnostic imaging. Neovascularization, Pathologic / diagnostic imaging. Ultrasonography, Doppler
  • [MeSH-minor] Adnexal Diseases / diagnostic imaging. Adolescent. Adult. Aged. Aged, 80 and over. Blood Flow Velocity. Diagnosis, Differential. Female. Humans. Middle Aged. ROC Curve. Retrospective Studies. Sensitivity and Specificity


38. Fan YS, Carr RA, Sanders DS, Smith AP, Lazar AJ, Calonje E: Characteristic Ber-EP4 and EMA expression in sebaceoma is immunohistochemically distinct from basal cell carcinoma. Histopathology; 2007 Jul;51(1):80-6
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  • A single case exhibited focal weak Ber-EP4 staining, predominantly in mature sebocytes and in < 10% of the tumour cells.
  • We reviewed the immunoreactivity of 51 cases of nodular BCCs and found moderate or strong BerEP4 expression in all cases with never less than 20% of the tumour staining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Mucin-1 / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 17593083.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; 0 / human epithelial antigen-125
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39. Kacerovska D, Michal M, Kazakov DV: Trichodiscoma with lipomatous metaplasia and pleomorphic stromal cells. J Cutan Pathol; 2010 Oct;37(10):1110-1
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  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology. Stromal Cells / pathology

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  • [CommentOn] J Cutan Pathol. 2010 Sep;37(9):987-90 [19843193.001]
  • (PMID = 20528968.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Denmark
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40. Mane DR, Kale AD, Hallikerimath S, Angadi P, Kotrashetti V: Trichilemmal carcinoma associated with xeroderma pigmentosa: report of a rare case. J Oral Sci; 2010 Sep;52(3):505-7
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  • Trichilemmal carcinoma is a rare malignant skin adnexal tumor derived from the outer root sheath epithelium of the hair follicle.
  • We demonstrate that this tumor, as well as the more frequently reported squamous cell carcinoma and basal cell carcinoma can occur in association with xeroderma pigmentosa.
  • [MeSH-major] Carcinoma, Skin Appendage / complications. Facial Neoplasms / complications. Hair Follicle / pathology. Lip Neoplasms / complications. Xeroderma Pigmentosum / complications

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  • (PMID = 20881348.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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41. Onodera H, Mihm MC Jr, Sato T, Matsuta M, Akasaka T, Nakamura S: A carcinoma with features of porocarcinoma, dermal ductular carcinoma, and squamous cell carcinoma in situ. Am J Dermatopathol; 2007 Feb;29(1):75-8
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  • The tumor had three different histologic components including porocarcinoma, dermal ductular carcinoma, and an area resembling squamous cell carcinoma in situ (SCCIS).
  • [MeSH-major] Carcinoma, Ductal / pathology. Carcinoma, Squamous Cell / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Back. Carcinoma in Situ / diagnosis. Carcinoma in Situ / pathology. Diagnosis, Differential. Female. Humans. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / pathology. Skin / pathology

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  • (PMID = 17284967.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Pulitzer M, Desman G, Busam KJ: CK7 expression in primary cutaneous squamous cell carcinoma. J Cutan Pathol; 2010 Sep;37(9):966-72
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  • METHODS: Twenty-seven primary cutaneous SCCs from 25 patients were evaluated for tumor grade using hematoxylin and eosin-stained slides and for percentage and intensity of immunoreactivity for CK7.
  • Of immunoreactive cases, percentage of tumor staining and distribution of immunoreactivity was documented.
  • The remaining immunoreactive tumor was moderately differentiated, with 1+ intensity and 5% staining in an area of microinvasion.
  • This is important to bear in mind when immunohistochemistry is used to distinguish SCC from simulants, such as porocarcinoma, or other adnexal carcinomas with squamous metaplasia.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. Keratin-7 / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Cell Count. Diagnosis, Differential. Eccrine Porocarcinoma / diagnosis. Humans. Immunohistochemistry. Neoplasms, Adnexal and Skin Appendage / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 20528966.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-7
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43. Hoang MP, Dresser KA, Kapur P, High WA, Mahalingam M: Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol; 2008 Feb;21(2):178-85
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  • [Title] Microcystic adnexal carcinoma: an immunohistochemical reappraisal.
  • Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain.
  • In this study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell carcinoma, and eight squamous cell carcinoma of which five exhibited ductal differentiation.
  • We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative.
  • Forty percent of infiltrative basal cell carcinoma expressed CK7; while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories.
  • While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases.
  • Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10.
  • BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma.
  • In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation.
  • Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15+ and BerEP4+/-; thus, additional studies are needed to separate these two entities.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Skin Appendage / chemistry. Head and Neck Neoplasms / chemistry. Immunohistochemistry / methods. Skin Neoplasms / chemistry


44. Fernandez-Flores A: Primary cutaneous apocrine carcinoma versus metastasis, a plea to the dermatopathology community. Am J Dermatopathol; 2010 Dec;32(8):853-4
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  • [MeSH-major] Apocrine Glands / pathology. Breast Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Second Primary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Predictive Value of Tests

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  • [CommentOn] Am J Dermatopathol. 2009 May;31(3):278-81 [19384070.001]
  • (PMID = 20431390.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Chaudhry IH, Zembowicz A: Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases. Arch Pathol Lab Med; 2007 Nov;131(11):1655-64
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  • [Title] Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases.
  • OBJECTIVE: To describe a previously unrecognized, distinctive cutaneous adnexal carcinoma capable of an aggressive clinical course.
  • Histologically, adnexal clear cell carcinoma with comedonecrosis was characterized by dermal proliferation of nests of epithelial cells showing distinctive zonal arrangement.
  • The periphery of the tumor nests was formed by squamoid cells merging with centrally located clear cell areas containing foci of comedonecrosis.
  • CONCLUSIONS: Adnexal clear cell carcinoma with comedonecrosis appears to be a distinctive adnexal neoplasm that has to be distinguished from more indolent squamous cell and tricholemmal carcinomas.
  • [MeSH-major] Acne Vulgaris / pathology. Carcinoma, Squamous Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • [CommentIn] Arch Pathol Lab Med. 2011 May;135(5):532; author reply 533 [21526948.001]
  • (PMID = 17979483.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-17; 0 / Mucin-1
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46. Gerber PA, Schulte KW, Ruzicka T, Bruch-Gerharz D: Eccrine porocarcinoma of the head: an important differential diagnosis in the elderly patient. Dermatology; 2008;216(3):229-33
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  • BACKGROUND: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations.
  • Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein.
  • All patients were initially diagnosed as having epidermal or melanocytic skin tumors.
  • CONCLUSION: Eccrine porocarcinomas are potentially fatal adnexal malignancies, in which extensive metastatic dissemination may occur.
  • Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors.
  • Knowledge of the clinical pattern and histologic findings, therefore, is crucial for an early therapeutic intervention, which can reduce the risk of tumor recurrence and serious complications.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Eccrine Glands / pathology. Head and Neck Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Skin Neoplasms / diagnosis

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  • (PMID = 18182815.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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47. Yu DK, Joo YH, Cho KH: Trichoblastoma with apocrine and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):6-8
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  • Trichoblastoma is a rare, benign tumor that differentiates toward the hair germ, the embryonic precursor of a hair follicle.
  • Several cases of trichoblastoma showed multiple differentiation toward more than one type of adnexal structure.
  • An immunohistochemical study showed that the neoplasm, or areas in it, stained positive for low molecular cytokeratin, high molecular cytokeratin, EMA, S-100, and GCDFP-15.
  • [MeSH-major] Apocrine Glands / pathology. Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Glands / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic. Female. Humans. Immunohistochemistry. Middle Aged. Treatment Outcome

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  • (PMID = 15677969.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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48. Huang W, Zhao Y, Zhao J, Huang Y, Wang J, Zhang Q: Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature. Pathol Res Pract; 2010 Mar 15;206(3):180-4
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  • [Title] Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature.
  • Endometrioid carcinoma is a common tumor of the female genital tract, mainly affecting the uterus corpus and ovary.
  • The female adnexal tumor of probable wolffian origin (FATWO), although occasionally seen elsewhere, is most typically encountered in the broad ligament.
  • The tumor was confined to the tube and strongly resembled FATWO.
  • Immunohistochemically, the tumor cells were positive for AE1/AE3, epithelial membrane antigen (EMA), and p16, but negative for CD10, inhibin-alpha, calretinin, vimentin, myogenin, and desmin, CD99,CgA, and Syn.
  • We review the previously published cases of endometrioid carcinomas of the fallopian tube resembling FATWO, and discuss the principal differential diagnosis of the tumor in the fallopian tube.
  • [MeSH-major] Endometrial Neoplasms / pathology. Fallopian Tube Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19457622.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
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49. Prayaga AK, Loya AC, Gottimukkala SR, Digumarti RR, Maddali LS, Challa S: Cytologic features of primary malignant tumors of skin and adnexae. Acta Cytol; 2008 Nov-Dec;52(6):702-9
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  • [Title] Cytologic features of primary malignant tumors of skin and adnexae.
  • STUDY DESIGN: Cases of primary malignant tumors of skin and adnexae diagnosed on cytology with histopathology confirmation were retrieved from case records of 1998-2005.
  • RESULTS: Thirty primary malignant tumors of skin and adnexae were analyzed.
  • There were 3 basal cell carcinomas and 2 cases each of sebaceous carcinoma, Paget's disease of the breast and lymphoma.
  • There were single cases of eccrine carcinoma, malignant trichilemmal tumor, undifferentiated carcinoma and extramedullary myeloid cell tumor.
  • All the cases of hemopoietic tumors (n=3) and the majority of the cases (4 of 7) of adnexal were seen to arise from head and neck region.
  • CONCLUSION: Cytodiagnosis of primary malignant tumors of skin and adnexae is possible based on morphology and clinical presentation.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Breast Neoplasms / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Cytodiagnosis. Humans. Lymphatic Metastasis. Medical Records. Melanoma / pathology. Paget's Disease, Mammary / pathology

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  • (PMID = 19068675.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Castori M, Ruggieri S, Giannetti L, Annessi G, Zambruno G: Schöpf-Schulz-Passarge syndrome: further delineation of the phenotype and genetic considerations. Acta Derm Venereol; 2008;88(6):607-12
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  • The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumours in 44% of affected subjects indicates that Schöpf-Schulz-Passarge is a genodermatosis with skin appendage neoplasms.
  • However, the risk of skin and visceral malignancies is not increased.
  • The benign disease course and advanced age at diagnosis could also suggest locus homogeneity for a recessive mutation with instances of pseudodominant inheritance.
  • [MeSH-minor] Aged. Anodontia / genetics. Consanguinity. Eyelid Neoplasms / genetics. Female. Hidrocystoma / genetics. Humans. Hypotrichosis / genetics. Keratoderma, Palmoplantar / genetics. Male. Nails, Malformed / genetics. Nipples / abnormalities. Optic Atrophy / genetics. Phenotype. Sweat Gland Neoplasms / genetics. Syndrome


51. Gomez-Maestra MJ, España-Gregori E, Aviñó-Martinez JA, Mancheño-Franch N, Peña S: Brainstem and cavernous sinus metastases arising from a microcystic adnexal carcinoma of the eyebrow by perineural spreading. Can J Ophthalmol; 2009 Jun;44(3):e17-8
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  • [Title] Brainstem and cavernous sinus metastases arising from a microcystic adnexal carcinoma of the eyebrow by perineural spreading.

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  • (PMID = 19506589.001).
  • [ISSN] 1715-3360
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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52. Ohtsuka H, Nozawa R, Kushida Y: Synchronous microcystic adnexal carcinoma and gastric cancer with review of the literature. J Dermatol; 2005 Jan;32(1):43-7
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  • [Title] Synchronous microcystic adnexal carcinoma and gastric cancer with review of the literature.
  • A microcystic adnexal carcinoma (MAC) on the left lateral chest was synchronously accompanied by both an adenocarcinoma and a granular cell tumor of the stomach in a 70-year-old Japanese male.
  • After a definitive diagnosis was made by an excisional biopsy, a second operation was performed with wider excision, followed by split thickness skin grafting.
  • Three lymph nodes were excised for diagnostic purposes and found to be reactive hyperplasia without metastasis of skin tumor cells.
  • [MeSH-major] Carcinoma, Skin Appendage / diagnosis. Granular Cell Tumor / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis. Stomach Neoplasms / diagnosis


53. González-Vela MC, Val-Bernal JF, González-López MA, Belaustegui I, Fernández-Llaca JH: Proliferating trichilemmal cyst associated with an epidermal nevus. J Dermatol; 2008 Jan;35(1):52-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / etiology. Nevus / complications. Skin / pathology. Skin Neoplasms / complications


54. Shapiro PE: Re: Familial desmoplastic trichoepithelioma. Int J Dermatol; 2007 Dec;46(12):1320-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics

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  • [CommentIn] Int J Dermatol. 2008 Nov;47(11):1210-1 [18986468.001]
  • [CommentOn] Int J Dermatol. 2006 Jun;45(6):756-8 [16796644.001]
  • (PMID = 18173540.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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55. Cribier B: [Accurate diagnosis of adnexal tumours can be a matter of life or death]. Ann Dermatol Venereol; 2009 Feb;136(2):125-32
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  • [Title] [Accurate diagnosis of adnexal tumours can be a matter of life or death].
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Diagnosis, Differential. Hamartoma Syndrome, Multiple / pathology. Humans. Male. Melanoma / pathology. Pilomatrixoma / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19232249.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 58
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56. McCalmont TH: The amazin' mets. J Cutan Pathol; 2010 Dec;37(12):1196-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Squamous Cell. Melanoma. Neoplasm Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage. Nevus, Pigmented. Skin Neoplasms
  • [MeSH-minor] Humans. Neoplasm Metastasis

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  • (PMID = 20950362.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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57. Regauer S, Nogales FF: Vulvar trichogenic tumors: a comparative study with vulvar basal cell carcinoma. Am J Surg Pathol; 2005 Apr;29(4):479-84
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  • Trichogenic tumors are very rare in genital skin and often cause diagnostic problems because they are mitotically active and they share some histologic features with basal cell carcinomas (BCCs).
  • BCCs showed no trichogenic differentiation and lacked an organized mesenchymal tumor component.
  • The tumor stroma of BCCs was paucicellular, mucinous, or granulation tissue-like with an inflammatory infiltrate.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged

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  • (PMID = 15767801.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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58. Kavand S, Cassarino DS: "Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma? Am J Dermatopathol; 2009 Dec;31(8):849-52
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  • [Title] "Squamoid eccrine ductal carcinoma": an unusual low-grade case with follicular differentiation. Are these tumors squamoid variants of microcystic adnexal carcinoma?
  • Squamoid eccrine ductal carcinoma is a rare primary cutaneous tumor exhibiting both squamous and adnexal ductal differentiation.
  • We report an additional case of a slow-growing tumor, occurring on the great toe of a 61-year-old woman, which was unusual as it showed follicular differentiation in addition to squamoid and ductal areas.
  • The lesional cells were positive for cytokeratins 7 and 17, carcinoembryonic antigen (which highlighted the ductal structures), and p63 (favoring a primary cutaneous tumor) and showed low levels of staining with Ki-67 and p53, consistent with a low-grade tumor.
  • We postulate that these tumors may be closely related to microcystic adnexal carcinoma and similarly show differentiation along both follicular and ductal lines, likely indicating folliculosebaceous-apocrine, rather than eccrine, origin or differentiation.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Hair Follicle / pathology. Skin Neoplasms / pathology

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  • (PMID = 19786851.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. O'Blenes CA, Lee JP, Walsh NM, Morris SF: An unusual case of turban tumor syndrome treated with total scalp excision and advancement flap and skin graft reconstruction. Ann Plast Surg; 2010 Jul;65(1):107-9
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  • [Title] An unusual case of turban tumor syndrome treated with total scalp excision and advancement flap and skin graft reconstruction.
  • We report an unusual case of aggressive turban tumor syndrome in a 38-year-old woman with nodules covering her scalp and involving her face, neck, chest, and back.
  • To address concerns regarding hygiene of the scalp and cosmetic disfigurement, she underwent total scalp excision with advancement flap and skin graft reconstruction.
  • Histologic examination of the scalp tumors revealed a predominance of spiradenomas, along with cylindromas and trichoepitheliomas, and tumors containing elements of all 3 of these adnexal neoplasms.
  • We review the literature regarding turban tumor syndrome including the genetic basis for this condition, clinical features, pathology, and treatment.
  • [MeSH-major] Carcinoma, Adenoid Cystic / surgery. Facial Neoplasms / surgery. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplasms, Second Primary / surgery. Scalp / surgery. Skin Neoplasms / surgery. Surgical Flaps

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  • (PMID = 20548229.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Mamelak AJ, Goldberg LH, Katz TM, Graves JJ, Arnon O, Kimyai-Asadi A: Desmoplastic trichoepithelioma. J Am Acad Dermatol; 2010 Jan;62(1):102-6
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  • BACKGROUND: Desmoplastic trichoepithelioma (DTE) is an uncommon adnexal tumor usually found on the face of young women.
  • CONCLUSION: DTE is a benign tumor that has a predilection for the face.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / pathology. Cheek. Female. Humans. Male. Middle Aged. Mohs Surgery. Retrospective Studies. Skin Neoplasms / pathology

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  • [CommentIn] J Am Acad Dermatol. 2011 Feb;64(2):438-9 [21238832.001]
  • (PMID = 20082889.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Li N, Wolgamot G, Argenyi Z: Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma. J Cutan Pathol; 2007 May;34(5):410-4
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  • Punch biopsies from both patients revealed an infiltrating neoplasm with prominent microcystic features that mimick tubuloglandular structures, lined by hyperchromatic basaloid cells, which were strongly positive for chromogranin and BerEP4, variably positive for CK7 and CK5/6 and negative for CK20, synaptophysin, S-100, epithelial membrane antigen (EMA), gross cystic disease fluid protein-15 (GCDFP-15), estrogen/progesterone receptors (ER/PR), thyroid transcription factor 1 (TTF1) and carcinoembryonic antigen (CEA).
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Diagnosis, Differential. Eccrine Glands / pathology. Humans. Immunohistochemistry. Male. Neck / pathology

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  • (PMID = 17448197.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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62. Carlson RM, Haddad L, Pui JC: Brooke-Spiegler syndrome with associated pegged teeth. Cutis; 2008 Nov;82(5):345-9
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  • This combination represents a rare genetic syndrome with tumors expressing adnexal differentiation.
  • Malignant transformation is rare but reported, and surgical excision is warranted to prevent turban tumor formation of the scalp.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / physiopathology. Skin Neoplasms / physiopathology. Tooth Abnormalities / etiology
  • [MeSH-minor] Adult. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / physiopathology. Female. Genetic Testing. Humans. Mutation. Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / genetics. Neoplastic Syndromes, Hereditary / physiopathology. Syndrome. Tumor Suppressor Proteins / genetics

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  • (PMID = 19090338.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
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63. Seaward JR, Kalipershad SN, Ross GL: Supraorbital neuroma masquerading as local recurrence from a previously excised microcystic adnexal carcinoma. J Plast Reconstr Aesthet Surg; 2010 Mar;63(3):e239-41
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  • [Title] Supraorbital neuroma masquerading as local recurrence from a previously excised microcystic adnexal carcinoma.
  • We present a case of a 53 year old gentleman with a previous history of a microcystic adnexal carcinoma in the supraorbital region who represented with pain and tenderness 3 years postoperatively.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasm Recurrence, Local / diagnosis. Orbital Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [Copyright] (c) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19648071.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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64. Zaraa I, Zeglaoui F, Fazaa B, Ezzine N, Elfekih N, Zermani R, Ben Jilani S, Kamoun MR: [Brooke-Spiegler syndrome]. Tunis Med; 2006 Sep;84(9):578-80
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  • [Transliterated title] Syndrome de brooke-Spiegler.
  • Brooke Spiegler syndrome is a rare genodermatosis characterized by an association of multiple trichoepitheliomas and cylindromas, sometimes accompanied by other adnexal tumors (spiradenoma, mila), we report two family cases of Brooke Spiegler syndrome.
  • No neoplastic tumor was identified.
  • A co-existence of adnexal tumors was found in the other members of the family.
  • Brooke Spiegler syndrome is an autosomial dominant disease with variable penetrance, it's characterized by a family history of trichoepitheliomas, with other adnexal tumors.
  • The course of the disease is characterized by a multiplication of lesions, a malignant transformation was reported, but remains rare.
  • Brooke Spiegler syndrome is usually a benign disease, but patients with this syndrome should be explored for malignancy.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics

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  • (PMID = 17263207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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65. Fang W, Chen D, Shang JF, Wang F, Xiao L: [Microcystic adnexal carcinoma: report of two cases]. Zhonghua Bing Li Xue Za Zhi; 2009 Jan;38(1):59-60
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  • [Title] [Microcystic adnexal carcinoma: report of two cases].
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Head and Neck Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19489229.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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66. Chi CC, Wang SH: Familial desmoplastic trichoepithelioma: limitation of electronic database search and solutions. Int J Dermatol; 2008 Nov;47(11):1210-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Carcinoma, Basal Cell / genetics. MEDLINE. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics

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  • [CommentOn] Int J Dermatol. 2007 Dec;46(12):1320-1 [18173540.001]
  • (PMID = 18986468.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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67. Khachemoune A, Olbricht SM, Johnson DS: Microcystic adnexal carcinoma: report of four cases treated with Mohs' micrographic surgical technique. Int J Dermatol; 2005 Jun;44(6):507-12
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  • [Title] Microcystic adnexal carcinoma: report of four cases treated with Mohs' micrographic surgical technique.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare and aggressive malignant tumor of the sweat glands.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Facial Neoplasms / surgery. Mohs Surgery. Scalp / surgery. Skin Neoplasms / surgery

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  • (PMID = 15941444.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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68. Kazakov DV, Vittay G, Michal M, Calonje E: High-grade trichoblastic carcinosarcoma. Am J Dermatopathol; 2008 Feb;30(1):62-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here we present the second case of this tumor, which, in contrast to the original example, may be classified as a high-grade neoplasm.
  • The tumor was excised, and the patient had no evidence of recurrence or metastasis 6 years after surgery.
  • Microscopically, the neoplasm demonstrated a fenestrated growth pattern with a slightly myxoid matrix in the background.
  • Despite the close association throughout the tumor, the epithelial and the stromal cells were sharply separated, without transition between both elements.
  • This conclusion is reached after analyzing the embryological development of the hair follicle, its normal histology and the morphology of cutaneous adnexal tumors with follicular differentiation.
  • [MeSH-major] Carcinosarcoma / pathology. Hair Diseases / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 18212548.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Klekowski N, Shwayder T: A surprising histopathology from a flesh-colored facial papule in a 12-year-old female. Pediatr Dermatol; 2009 Jan-Feb;26(1):91-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 19250418.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Kariya Y, Moriya T, Suzuki T, Chiba M, Ishida K, Takeyama J, Endoh M, Watanabe M, Sasano H: Sex steroid hormone receptors in human skin appendage and its neoplasms. Endocr J; 2005 Jun;52(3):317-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sex steroid hormone receptors in human skin appendage and its neoplasms.
  • Sex steroids have been postulated to influence pathophysiology of human skin through various skin appendages.
  • The presence of sex steroid receptors has been also reported in adnexal tumors but its details still remained unknown.
  • Therefore, in this study, we immunolocalized sex steroid receptor protein (estrogen receptor (ER)alpha, ERbeta, progesterone receptor (PR)A, PRB and androgen receptor (AR)) in 23 cases of non-pathological skin (male: 10, female: 13) and in 50 cases of skin adnexal tumors (male 24, female 26; 38 benign and 12 malignant).
  • ERalpha immunoreactivity was detected exclusively in basal cells of sebaceous glands of non-pathological skin.
  • In sebaceous gland neoplasms, the number of ERalpha positive cases was significantly lower in skin appendage neoplasms than non-pathological skin.
  • ERbeta immunoreactivity was not detected in any of sebaceous gland neoplasms examined.
  • There were no significant differences in PRA, PRB and AR immunoreactivity between non-pathological sebaceous gland and its neoplasm.
  • In sweat gland neoplasms, the number of AR positive cases was significantly lower in benign neoplasms than their non-pathological counterpart.
  • Therefore sex steroids are considered to play important roles in regulation of non-pathological skin appendage function and pathogenesis and/or development of its neoplasm.
  • In addition, the status of the great majority of sex steroid hormone receptors was maintained throughout the process of neoplastic transformation of skin appendages, except for AR and ERalpha in sweat and sebaceous gland neoplasms.
  • [MeSH-major] Carcinoma, Skin Appendage / metabolism. Receptors, Steroid / metabolism. Sebaceous Gland Neoplasms / metabolism. Sweat Gland Neoplasms / metabolism

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  • (PMID = 16006726.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Receptors, Androgen; 0 / Receptors, Progesterone; 0 / Receptors, Steroid; 0 / progesterone receptor A; 0 / progesterone receptor B
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71. Kamiya H, Kitajima Y, Ban M: Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells. J Dermatol; 2006 Dec;33(12):858-64
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  • [Title] Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
  • Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions.
  • Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition.
  • Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma.
  • The plaque lesions possessed clinical features typical of Bowen's disease.
  • In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma.
  • The tumor in case 2 was characteristic to trichilemmal carcinoma.
  • Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities.
  • The present cases support a notion that Bowen's disease maintains a pluripotential nature.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma, Skin Appendage / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Acrospiroma / pathology. Aged. Aged, 80 and over. Female. Humans. Neoplasm Invasiveness. Neoplasms, Basal Cell / pathology

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  • (PMID = 17169090.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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72. Kanitakis J: Adnexal tumours of the skin as markers of cancer-prone syndromes. J Eur Acad Dermatol Venereol; 2010 Apr;24(4):379-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal tumours of the skin as markers of cancer-prone syndromes.
  • Adnexal tumours of the skin are benign, more rarely malignant, primary skin tumours that originate from, or differentiate towards, hair follicles, sebaceous and sweat glands.
  • Dermatologists should be aware of these adnexal skin tumours, the diagnosis of which may contribute to an early detection of a cancer-prone syndrome with a potentially lethal outcome.
  • [MeSH-major] Epidermal Cyst / pathology. Muir-Torre Syndrome / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19744258.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers
  • [Number-of-references] 77
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73. Leibovitch I, Huilgol SC, Selva D, Lun K, Richards S, Paver R: Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery. J Am Acad Dermatol; 2005 Feb;52(2):295-300
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  • [Title] Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is reported to have a high rate of recurrence with standard wide local excision.
  • METHODS: This prospective, multi-center case series included all patients in Australia treated with MMS for MAC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002.
  • In 31.8% of cases it was a recurrent tumor.
  • In 32.5% of cases the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Skin Appendage / surgery. Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Australia / epidemiology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Child. Databases, Factual. Diagnostic Errors. Female. Follow-Up Studies. Head and Neck Neoplasms / diagnosis. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prospective Studies. Retrospective Studies. Treatment Outcome


74. Carter JJ, Kaur MR, Hargitai B, Brown R, Slator R, Abdullah A: Congenital desmoplastic trichoepithelioma. Clin Exp Dermatol; 2007 Sep;32(5):522-4
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  • Desmoplastic trichoepithelioma (DT) is a rare benign adnexal neoplasm considered to have follicular differentiation.
  • [MeSH-major] Facial Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin / pathology

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  • (PMID = 17459070.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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75. Lucas Costa A, Betlloch I, Pérez-Crespo M, Mataix J, Bañuls J: Mammary skin tag in a 2-year-old girl: a long-lasting adnexal polyp of neonatal skin? Pediatr Dermatol; 2009 Sep-Oct;26(5):618-20
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  • [Title] Mammary skin tag in a 2-year-old girl: a long-lasting adnexal polyp of neonatal skin?
  • Clinical and histological features were consistent with an adnexal polyp of neonatal skin observed beyond the neonatal period.
  • [MeSH-major] Breast Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Nipples / pathology

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  • (PMID = 19840327.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Chetty R, Perez-Ordonez B, Gilbert R, Pagedar NA, Waldron J, Ghazarian D: Spiradenocarcinoma arising from a spiradenocylindroma: unusual case with lymphoepithelioma-like areas. J Cutan Med Surg; 2009 Jul-Aug;13(4):215-20
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  • BACKGROUND: Hybrid skin adnexal tumors are common, and spiradenocylindroma is well described.
  • OBJECTIVE: However, malignant transformation in this setting is infrequent, especially resemblance to lymphoepithelioma-like carcinoma of skin, which is not associated with Epstein-Barr virus.
  • METHODS: A 65-year-old female presented with ataxia and a skin nodule composed of a hybrid adnexal tumor (spiradenoma and cylindroma) that transitioned into an undifferentiated carcinoma with attendant lymphocytes and plasma cells.
  • The tumor was Epstein-Barr encoded RNAs (EBER) negative by in situ hybridization.
  • No evidence of neuroendocrine differentiation was seen in the tumor, despite the patient having symptoms of paraneoplastic ataxia that improved after surgery.
  • CONCLUSION: This case highlights the transition of a benign hybrid tumor (spiradenocylindroma) into a spiradenocarcinoma that resembled lymphoepithelioma-like carcinoma of skin.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 19706230.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Fischer S, Breuninger H, Metzler G, Hoffmann J: Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg; 2005 Jan;16(1):53-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor.
  • Microcystic adnexal carcinoma (MAC) belongs to the spectrum of locally aggressive adnexal carcinomas and most commonly occurs in the head and neck region.
  • Recently it has been proposed that MAC is an apocrine tumor.
  • The authors report the case of a 78-year-old woman in whom a diagnosis of MAC was made when a tumor on the right cheek recurred for the second time.
  • Local recurrences of the tumor occurred, despite histographic surgery because in hematoxylin and eosin stains, small islands of the deceptively benign-appearing small basaloid cells of MAC were not recognized as tumor cells.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasms, Basal Cell / pathology

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  • (PMID = 15699645.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Charfi S, Sevestre H, Dumont F, Regimbeau JM, Chatelain D: Atypical apocrine proliferation involving anogenital mammary-like glands of the perianal region. J Cutan Pathol; 2009 Oct;36 Suppl 1:52-5
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  • Normal MLGs were observed at the tumor periphery.
  • [MeSH-major] Apocrine Glands / pathology. Genitalia, Female / pathology. Mammary Glands, Human / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • (PMID = 19775395.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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79. Campbell RM, Barrall D, Wilkel C, Robinson-Bostom L, Dufresne RG Jr: Post-Mohs micrographic surgical margin tissue evaluation with permanent histopathologic sections. Dermatol Surg; 2005 Jun;31(6):655-8; discussion 658
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Incomplete resection of nonmelanoma skin cancer is associated with a relatively high rate of recurrent tumors.
  • Mohs micrographic surgery provides microscopic evaluation of tumor margins to ensure complete excision of nonmelanoma skin cancers at high risk of recurrence.
  • OBJECTIVE: This purpose of this study is to confirm the histologic accuracy of Mohs excision of facial skin cancers by evaluating an additional layer of tissue with permanent histopathologic sections after Mohs excision.
  • A review of the pathology reports and tissue specimens on these patients provides valuable data on tumor margins and the effectiveness of the Mohs technique for tumor excision.
  • RESULTS: Two excisions of nodular basal cell cancer were determined by the pathologist to have positive tumor involvement on post-Mohs permanent tissue.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Facial Neoplasms / surgery. Mohs Surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Male. Middle Aged. Neoplasms, Adnexal and Skin Appendage / surgery. Postoperative Period. Retrospective Studies

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  • [CommentIn] Dermatol Surg. 2006 Mar;32(3):463 [16640701.001]
  • (PMID = 15996415.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Mulder MM, Heddema ER, Pannekoek Y, Faridpooya K, Oud ME, Schilder-Tol E, Saeed P, Pals ST: No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands. Leuk Res; 2006 Oct;30(10):1305-7
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  • [Title] No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands.
  • Recently, conflicting data have been published regarding a possible association between Chlamydia psittaci and ocular adnexal MZBCL.
  • In the present study, we analyzed a cohort of ocular adnexal MZBLs from the Netherlands for the presence of C. psittaci DNA.
  • We found no evidence for the presence of C. psittaci DNA in any of the tumor samples studied.
  • Our data do not support a role for C. psittaci in the pathogenesis of ocular adnexal lymphomas in patients from the Netherlands.
  • [MeSH-major] Chlamydia Infections / complications. Chlamydophila psittaci. Eye Neoplasms / epidemiology. Lymphoma, B-Cell / epidemiology. Neoplasms, Adnexal and Skin Appendage / epidemiology

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  • (PMID = 16420962.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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81. Pincus LB, McCalmont TH, Neuhaus IM, Kasper R, Oh DH: Basal cell carcinomas arising within multiple trichoepitheliomas. J Cutan Pathol; 2008 Oct;35 Suppl 1:59-64
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  • We describe a 57-year-old male with numerous skin-colored firm papules and plaques present on the central face since 6 years of age.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Basal Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • [Copyright] Copyright Blackwell Munksgaard 2008.
  • (PMID = 18544067.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Keratin-20; 0 / Proto-Oncogene Proteins c-bcl-2
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82. Swick BL, Baum CL, Walling HW: Rippled-pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature. J Cutan Pathol; 2009 Nov;36(11):1200-5
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  • Histologic sections of the papular growth at the superior pole of the nevus sebaceus showed a proliferation of cytologically bland basaloid epithelial tumor lobules both in the superficial dermis, with multiple connections to the epidermis, and within the deeper dermis in a nodular growth pattern demonstrating papillary mesenchymal bodies.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / complications. Neoplasms, Adnexal and Skin Appendage / pathology. Nevus, Sebaceous of Jadassohn / complications

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  • (PMID = 19469871.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 32
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83. Herwig MC, Vogel A, Holz FG, Löffler KU: [Pilomatrixoma of the ocular adnexae: clinical and histologic analysis (13 cases)]. Klin Monbl Augenheilkd; 2009 May;226(5):404-8
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  • [Transliterated title] Pilomatrixom der okulären Adnexe: Klinische und histologische Aufarbeitung von 13 Fällen.
  • BACKGROUND: Pilomatrixoma (calcifying epithelioma of Malherbe) is a rare benign tumour originating from the matrix of the hair root.
  • In this study, we evaluated the clinical and histopathological characteristics of all the respective tumour specimens submitted to our laboratory since 1997.
  • There was no tumour recurrence in any of the cases within the time period presented.
  • No correlation was found between any of the histological or immunohistochemical markers and clinical parameters such as size, age and gender of the patient and duration of tumour presence prior to surgery.
  • [MeSH-major] Hair Diseases / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19399712.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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84. Sgambato A, Zalaudek I, Ferrara G, Giorgio CM, Moscarella E, Nicolino R, Argenziano G: Adnexal tumors: clinical and dermoscopic mimickers of basal cell carcinoma. Arch Dermatol; 2008 Mar;144(3):426
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  • [Title] Adnexal tumors: clinical and dermoscopic mimickers of basal cell carcinoma.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18347310.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Ivan D, Diwan AH, Lazar AJ, Prieto VG: The usefulness of p63 detection for differentiating primary from metastatic skin adenocarcinomas. J Cutan Pathol; 2008 Sep;35(9):880-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The usefulness of p63 detection for differentiating primary from metastatic skin adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / diagnosis. Biomarkers, Tumor / metabolism. Membrane Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentOn] J Cutan Pathol. 2008 Jul;35(7):692-3 [18312438.001]
  • (PMID = 18796086.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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86. Ivan D, Nash JW, Prieto VG, Calonje E, Lyle S, Diwan AH, Lazar AJ: Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin. J Cutan Pathol; 2007 Jun;34(6):474-80
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  • [Title] Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin.
  • p63, a recently identified homologue of the p53 gene, is mainly expressed by basal and myoepithelial cells in skin.
  • Others and we have shown the value of p63 in distinguishing primary adnexal tumors from visceral adenocarcinomas metastatic to skin.
  • We now investigate the pattern of p63 expression in metastases from skin adnexal carcinomas and their cognate primaries and evaluate p63 expression in a larger case series of malignant cutaneous adnexal neoplasms.
  • Immunohistochemical analysis for p63 was performed on 13 metastases of adnexal carcinomas and their corresponding primary tumors.
  • Twenty visceral metastatic adenocarcinomas to the skin and 7 primary mucinous carcinomas with cutaneous or visceral origin were compared.
  • The majority (90.9%) of primary adnexal tumors strongly expressed p63 and their metastases labeled similar to their cognate primary tumors.
  • Analysis of p63 expression may assist in the differential diagnosis of primary adnexal carcinomas versus metastatic visceral adenocarcinomas to the skin.
  • Metastases from adnexal carcinomas generally retain p63 expression similar to their associated primary tumors.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Biomarkers, Tumor / metabolism. DNA-Binding Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism

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  • [CommentIn] J Cutan Pathol. 2008 Jul;35(7):692-3 [18312438.001]
  • (PMID = 17518775.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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87. Vidal VP, Ortonne N, Schedl A: SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. J Cutan Pathol; 2008 Apr;35(4):373-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms.
  • Here we test whether activation of SOX9 is a general feature of BCC, or whether it could be used as a biomarker to better define subtypes of these skin tumors.
  • In addition we investigated SOX9 expression in other skin epidermal tumors.
  • Staining was heterogeneous and could be detected among the basaloid cells of the palisading cell layer as well as in the tumour nest.
  • SOX9 expression was detected in all adnexal tumors analyzed and absent in Bowen's disease and Merkel tumor.
  • CONCLUSIONS: SOX9 expression is a general feature of BCC and adnexal skin neoplasms, suggesting a contribution of SOX9 to the pathogenesis of these tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. High Mobility Group Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism. Transcription Factors / metabolism

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  • (PMID = 18333897.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / High Mobility Group Proteins; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / Transcription Factors
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88. Obaidat NA, Alsaad KO, Ghazarian D: Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol; 2007 Feb;60(2):145-59
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  • [Title] Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands.
  • Tumours of cutaneous sweat glands are uncommon, with a wide histological spectrum, complex classification and many different terms often used to describe the same tumour.
  • In addition to the eccrine and apocrine glands, two other skin sweat glands have recently been described: the apoeccrine and the mammary-like glands of the anogenital area.
  • In this review (the second of two articles on skin adnexal neoplasms), common as well as important benign and malignant lesions of cutaneous sweat glands are described, and a summary for differentiating primary adnexal neoplasms from metastatic carcinoma is outlined, striving to maintain a common and acceptable terminology in this complex subject.
  • Composite/mixed adnexal tumours are also discussed briefly.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Sweat Gland / pathology. Carcinoma, Skin Appendage / pathology. Humans. Syringoma / pathology

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  • (PMID = 16882695.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 110
  • [Other-IDs] NLM/ PMC1860616
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89. Erwin WD, Esmaeli B: Estimation of yttrium-90 Zevalin tumor-absorbed dose in ocular adnexal lymphoma using quantitative indium-111 Zevalin radionuclide imaging. Nucl Med Commun; 2009 Sep;30(9):681-6
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  • [Title] Estimation of yttrium-90 Zevalin tumor-absorbed dose in ocular adnexal lymphoma using quantitative indium-111 Zevalin radionuclide imaging.
  • OBJECTIVE: The purpose of this investigation was to estimate radiation-absorbed dose in orbital tumors from yttrium-90 ibritumomab tiuxetan (Zevalin) radioimmunotherapy of ocular adnexal lymphoma.
  • METHODS: Three patients participating in a prospective research protocol involving treatment of ocular adnexal lymphoma with yttrium-90 Zevalin consented to quantitative radionuclide imaging to estimate tumor radiation-absorbed doses.
  • Each patient received 185 MBq of indium-111 Zevalin, followed by serial planar whole-body scanning, to derive an activity versus time curve for the tumor.
  • Single photon emission computed tomography (SPECT) and computed tomography (CT) imaging, including a calibration source, were performed at 24 h on a SPECT/CT scanner, to obtain a SPECT estimate of the radioactivity (in megabequerels) in the tumor and correct the planar curve, as well as estimate the tumor mass (M) from CT.
  • The curve was then converted to that for yttrium-90 at the prescribed activity, and absorbed dose estimated from the area under the curve multiplied by the Medical Internal Radiation Dose S value (Gy per MBq-h) for a sphere of mass M.
  • RESULTS: A right orbital tumor in one patient was visualized in both the planar and SPECT/CT images, with an estimated absorbed dose of 3.57 Gy.
  • Tumor uptake in the other two patients was not visualized.
  • CONCLUSION: The radiation dose to the orbit and ocular structures during radioimmunotherapy of ocular adnexal lymphoma is well below the threshold for significant radiation-induced ocular toxicity and about 10 times lower than that delivered during external beam radiotherapy.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Eye Neoplasms. Lymphoma. Neoplasms, Adnexal and Skin Appendage. Radiation Dosage. Yttrium / chemistry

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  • (PMID = 19528874.001).
  • [ISSN] 1473-5628
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Indium Radioisotopes; 0 / ibritumomab tiuxetan; 58784XQC3Y / Yttrium
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90. Torres A, Torres K, Paszkowski T, Staśkiewicz G, Maciejewski R, Woźniakowska E, Zaleska W: [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy]. Ginekol Pol; 2007 Oct;78(10):764-7
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  • [Title] [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy].
  • OBJECTIVES: The aim of the study was to compare serum concentrations of the TNF-alpha (TNF-alpha) in the early postoperative period in patients with benign adnexal masses operated by laparoscopy or laparotomy.
  • MATERIAL AND METHODS: The study was conducted in a group of patients aged from 20 to 52, operated due to adnexal masses.
  • [MeSH-major] Biomarkers, Tumor / blood. Laparoscopy. Laparotomy. Ovarian Diseases / blood. Ovarian Diseases / surgery. Postoperative Period. Tumor Necrosis Factor-alpha / blood
  • [MeSH-minor] Adnexal Diseases / blood. Adnexal Diseases / surgery. Adult. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Adnexal and Skin Appendage / blood. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / surgery. Ovarian Neoplasms / blood. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18200965.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Necrosis Factor-alpha
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91. Yen CF, Lin SL, Murk W, Wang CJ, Lee CL, Soong YK, Arici A: Risk analysis of torsion and malignancy for adnexal masses during pregnancy. Fertil Steril; 2009 May;91(5):1895-902
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  • [Title] Risk analysis of torsion and malignancy for adnexal masses during pregnancy.
  • OBJECTIVE: To find the risk factors of torsion and malignancy for adnexal tumors during pregnancy.
  • PATIENT(S): Patients from 1990 to 2004 with adnexal tumors >or=4 cm during pregnancy.
  • MAIN OUTCOME MEASURE(S): Tumor size, progression, pathology, incidence of malignancy, and torsion.
  • In 174 patients who were followed through pregnancy with known tumor existence, 14.84% +/- 3.05% encountered tumor torsion.
  • Adnexal masses with sizes between 6 and 8 cm had a significantly higher risk of torsion compared with other sizes (22.41% vs. 9.48%; odds ratio 2.8, 95% confidence interval [CI], [1.1, 6.6]).
  • Tumor diameters >or=10 cm at initial diagnosis had a higher risk of malignancy versus smaller sizes (8.77% vs. 0.85%; odds ratio 11.2, 95% CI, [1.3, 97.9]), and tumor growth rates >or=3.5 cm/week also had a significantly higher risk of malignancy versus lower rates (8.33% vs. 0.88%; odds ratio 10.2, 95% CI, [1.0, 101.2]).
  • CONCLUSION(S): Adnexal tumors bearing higher risks for torsion and malignancy should be strongly considered for an aggressive strategy of management during pregnancy.
  • [MeSH-major] Adnexal Diseases / complications. Pregnancy Complications, Neoplastic. Torsion Abnormality / etiology
  • [MeSH-minor] Adult. Cohort Studies. Disease Progression. Female. Gestational Age. Humans. Neoplasms, Adnexal and Skin Appendage. Pregnancy. Retrospective Studies. Risk Factors

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  • (PMID = 18359024.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Mahalingam M, Srivastava A, Hoang MP: Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis. Am J Dermatopathol; 2010 Dec;32(8):774-9
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  • [Title] Expression of stem-cell markers (cytokeratin 15 and nestin) in primary adnexal neoplasms-clues to etiopathogenesis.
  • BACKGROUND: The overlap in histopathologic features and immunoprofile of eccrine and apocrine neoplasms confounds basic issues relating to lineage of these entities.
  • METHODS: We evaluated expression of follicular stem-cell markers, cytokeratin (CK) 15 and nestin, in 78 benign and 23 malignant adnexal neoplasms.
  • RESULTS: CK15 and nestin expression were noted in 39 of 78 (50%) and 36 of 78 (46%) cases in the benign group, respectively (8 cutaneous mixed tumor, 10 hidradenoma papilliferum, 9 apocrine cystadenoma, 11 cylindroma and/or spiradenoma, and 9 poroma/dermal duct tumor).
  • CK15 and nestin expression were noted in 11 of 23 (48%) and 7 of 23 (30%) cases in the malignant group, respectively (6 microcystic adnexal carcinoma, 7 porocarcinoma, and 9 eccrine carcinoma).
  • Except 1, both markers were negative in 4 syringocystadenoma papilliferum, 10 hidradenoma, 1 syringofibroadenoma, 10 syringoma, 1 eccrine adenoma, 8 poroma/dermal duct tumor, 5 eccrine hidrocystoma, and 1 apocrine carcinoma.
  • CONCLUSIONS: Given that follicular germinative cells give rise to the folliculosebaceous apocrine unit, expression of CK15 and nestin in the majority of cutaneous mixed tumor, hidradenoma papilliferum, apocrine cystadenoma, and cylindroma/spiradenoma is suggestive of an apocrine origin/differentiation of these neoplasms.
  • Reinforcing this and a novel finding of our study is the preferential expression of nestin in myoepithelial cells of these lesions.
  • [MeSH-major] Apocrine Glands / chemistry. Biomarkers, Tumor / analysis. Eccrine Glands / chemistry. Intermediate Filament Proteins / analysis. Keratin-15 / analysis. Neoplasms, Adnexal and Skin Appendage / chemistry. Neoplastic Stem Cells / chemistry. Nerve Tissue Proteins / analysis. Sweat Gland Neoplasms / chemistry
  • [MeSH-minor] Boston. Cell Lineage. Diagnosis, Differential. Humans. Immunohistochemistry. Nestin. Predictive Value of Tests

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  • (PMID = 20700038.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT15 protein, human; 0 / Keratin-15; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
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93. Tasaki K, Shichishima A, Furuta M, Yoshida S, Nakamura N, Abe M: CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma of ocular adnexal origin: usefulness of fluorescence in situ hybridization for distinction between mantle cell lymphoma and MALT lymphoma. Pathol Int; 2007 Feb;57(2):101-7
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  • [Title] CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma of ocular adnexal origin: usefulness of fluorescence in situ hybridization for distinction between mantle cell lymphoma and MALT lymphoma.
  • Herein is described two cases of CD5-positive MALT lymphoma of ocular adnexal origin.
  • [MeSH-major] Antigens, CD5 / metabolism. Eye Neoplasms / diagnosis. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, Mantle-Cell / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis
  • [MeSH-minor] Aged. Cyclin D1 / genetics. Cyclin D1 / metabolism. DNA, Neoplasm / genetics. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Immunoglobulin Heavy Chains / genetics. Immunoglobulin Heavy Chains / metabolism. In Situ Hybridization, Fluorescence. Male. Middle Aged


94. Carvalho J, Fullen D, Lowe L, Su L, Ma L: The expression of CD23 in cutaneous non-lymphoid neoplasms. J Cutan Pathol; 2007 Sep;34(9):693-8
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  • [Title] The expression of CD23 in cutaneous non-lymphoid neoplasms.
  • CD23 staining was seen in 42% (8/19) of microcystic adnexal carcinoma (MAC), while no staining was observed in tumor cells of desmoplastic trichoepithelioma, morpheaform basal cell carcinoma and syringoma.
  • All mammary and extramammary Paget's disease were labeled with CD23.
  • In comparison, pagetoid Bowen's disease, melanoma in situ and sebaceous carcinoma exhibited negative staining.
  • It is of ancillary value in differentiating MAC from its mimicker.
  • CD23 is a useful addition to the diagnostic immunohistochemical panels for Paget's disease.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptors, IgE / metabolism. Sweat Gland Neoplasms / metabolism

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  • (PMID = 17696916.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, IgE
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95. Nagatsuka H, Rivera RS, Gunduz M, Siar CH, Tamamura R, Mizukawa N, Asaumi J, Nagai N: Microcystic adnexal carcinoma with mandibular bone marrow involvement: a case report with immunohistochemistry. Am J Dermatopathol; 2006 Dec;28(6):518-22
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  • [Title] Microcystic adnexal carcinoma with mandibular bone marrow involvement: a case report with immunohistochemistry.
  • Microcystic adnexal carcinoma is a rare, locally aggressive cutaneous neoplasm with a high probability of persistence locally but a low probability of metastasis.
  • Histologically, the tumor cells invaded the subcutaneous tissue and mandibular bone.
  • The tumor consisted mainly of squamous and basaloid epithelial nests and cords embedded in a desmoplastic stroma.
  • Our results indicate that microcystic adnexal carcinoma consists of tumor cells capable of both follicular and eccrine differentiation.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Lip Neoplasms / pathology. Mandibular Neoplasms / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Carcinoembryonic Antigen / metabolism. Female. Humans. Immunohistochemistry. Neoplasm Recurrence, Local / pathology. Neoplasms, Germ Cell and Embryonal / pathology. S100 Proteins / metabolism

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  • (PMID = 17122497.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / S100 Proteins
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96. Ivan D, Hafeez Diwan A, Prieto VG: Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin. Mod Pathol; 2005 Jan;18(1):137-42
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  • [Title] Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin.
  • The purpose of this study was to investigate the pattern of p63 expression in cutaneous adnexal neoplasms and to assess its possible value in the differential diagnosis of primary cutaneous neoplasms vs adenocarcinomas metastatic to the skin.
  • Immunohistochemical analysis for p63 was performed on formalin-fixed, paraffin-embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors and 14 adenocarcinomas metastatic to the skin.
  • The expression of p63 was evaluated in epidermal cells, skin appendages and metastatic tumor cells. p63 was consistently expressed in the basal and suprabasal cells of epidermis and cutaneous appendages, including the basal/myoepithelial cells of sweat glands.
  • Out of 20 benign adnexal tumors, 13 (65%) showed strong (score 3) p63 expression; the remaining seven (35%) cases had score 2.
  • In contrast, none of the metastatic adenocarcinomas to the skin was positive for p63 (P<0.001).
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasms, Adnexal and Skin Appendage / pathology. Phosphoproteins / biosynthesis. Skin / pathology. Skin Neoplasms / pathology. Trans-Activators / biosynthesis
  • [MeSH-minor] DNA-Binding Proteins. Diagnosis, Differential. Epidermis / chemistry. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Transcription Factors. Tumor Suppressor Proteins


97. Islam MN, Bhattacharyya I, Proper SA, Glanz SM, Vega JM, Hassanein AM: Melanocytic matricoma: a distinctive clinicopathologic entity. Dermatol Surg; 2007 Jul;33(7):857-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Biomarkers, Tumor / analysis. Hair Diseases / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Pilomatrixoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17598856.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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98. Layegh P, Sharifi-Sistani N, Abadian M, Moghiman T: Brooke-Spiegler syndrome. Indian J Dermatol Venereol Leprol; 2008 Nov-Dec;74(6):632-4
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  • The Brooke-Spiegler syndrome (BSS) is an uncommon autosomal dominant disorder characterized by a high affinity to form multiple adnexal neoplasia (skin appendage tumors), especially trichoepitheliomas and cylindromas, and occasionally spiradenomas, which usually appear in the second or third decade of life.
  • On examination, several round-to-oval skin-colored papules with a smooth pearly surface measuring 2 to 6 mm in diameter were seen on the mid-face, particularly in the nasolabial folds, the upper lip.
  • [MeSH-major] Skin Neoplasms / diagnosis. Skin Neoplasms / surgery

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  • (PMID = 19171990.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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99. Gabillot-Carré M, Weill F, Mamelle G, Kolb F, Boitier F, Petrow P, Ortoli JC, Margulis A, Souteyrand P, Mercier S, Spatz A, Duvillard P, Validire P, Avril MF: Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis. Dermatology; 2006;212(3):221-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis.
  • BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm, with a high rate of local recurrences.
  • In 3 patients, the course of the disease was severe: one of them developed pathologically proven lung metastasis.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Facial Neoplasms / pathology. Lung Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local

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  • [Copyright] 2006 S. Karger AG, Basel
  • (PMID = 16549917.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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100. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Familial cylindromatosis (Brooke-Spiegler syndrome) is a rare autosomal dominant inherited disease characterized by the development of adnexal tumors, mostly cylindromas, but also trichoepitheliomas and spiradenomas.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • Since the Brooke-Spiegler syndrome is characterized by a germline mutation in the CYLD oncosuppressor gene, a biphasic tumor in this setting may represent a true carcinosarcoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

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  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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