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1. Schanz A, Richter J, Beyer I, Baldus SE, Hess AP, Kruessel JS: Genital schistosomiasis as a cause of female sterility and acute abdomen. Fertil Steril; 2010 Apr;93(6):2075.e7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To report the case of a Nigerian patient who suffered from sterility and underwent abdominal laparotomy to remove an adnexal tumor.
  • PATIENTS: One patient who underwent an abdominal laparotomy to remove an adnexal tumor.
  • INTERVENTION(S): In vitro fertilization and adnexal tumor resection via laparotomy.
  • MAIN OUTCOME MEASURE(S): Treatment of the adnexal tumor affecting the reproductive health.

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  • [Copyright] Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20138271.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Kamiya H, Kitajima Y, Ban M: Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells. J Dermatol; 2006 Dec;33(12):858-64
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  • [Title] Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
  • Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions.
  • Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition.
  • Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma.
  • In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma.
  • The tumor in case 2 was characteristic to trichilemmal carcinoma.
  • Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities.
  • [MeSH-major] Bowen's Disease / pathology. Carcinoma, Skin Appendage / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology

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  • (PMID = 17169090.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Kazakov DV, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, Grossmann P, Michal M: Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol; 2009 May;31(3):248-55
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  • [Title] Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
  • Previous studies suggested that mutant beta-catenin gene cells in cutaneous adnexal tumors with matrical differentiation contribute to their tumorigenesis.
  • Except for pilomatricoma and pilomatrical carcinoma, only a handful of other cutaneous adnexal tumor types have been studied.
  • DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene.
  • These included 5 different point mutations, 3 of them identified in 2 different tumors: S23N (cribriform trichoblastoma), D32Y (pilomatricoma and craniopharyngioma), G34R (pilomatrical carcinoma and craniopharyngioma), S37F (2 BCCs with shadow cell differentiation), and G34V (craniopharyngioma).
  • This study broadens the list of cutaneous adnexal tumors harboring CTNNB1 mutations and extends the listing of the mutations occurring in these neoplasms.
  • [MeSH-major] Exons. Mutation. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics. beta Catenin / genetics

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  • (PMID = 19384065.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
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4. Alexander MP, Makhija P, Jayaseelan E: Fine needle aspiration cytology of trichofolliculoma: a case report. Indian J Pathol Microbiol; 2007 Oct;50(4):870-2
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  • The cytomorphology of skin adnexal tumours has not been described extensively in literature.
  • Cytology is a useful tool in the diagnosis of skin adnexal tumours.
  • [MeSH-major] Hair Follicle / pathology. Hamartoma / diagnosis. Hamartoma / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 18306593.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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5. Navi D, Fung M, Lynch PJ: Poromatosis: the occurrence of multiple eccrine poromas. Dermatol Online J; 2008;14(1):3
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  • Eccrine poromas are rare, benign adnexal tumors derived from the intraepidermal portion of sweat ducts.
  • They usually appear as solitary, slow-growing, skin-colored papules on acral surfaces.
  • Here we present the unusual situation of a patient with multiple poromas only three of which are located near the distal extremities.

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  • (PMID = 18319020.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Huang W, Zhao Y, Zhao J, Huang Y, Wang J, Zhang Q: Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature. Pathol Res Pract; 2010 Mar 15;206(3):180-4
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  • [Title] Endometrioid carcinoma of the fallopian tube resembling an adnexal tumor of probable wolffian origin: a case of report and review of the literature.
  • Endometrioid carcinoma is a common tumor of the female genital tract, mainly affecting the uterus corpus and ovary.
  • The female adnexal tumor of probable wolffian origin (FATWO), although occasionally seen elsewhere, is most typically encountered in the broad ligament.
  • The tumor was confined to the tube and strongly resembled FATWO.
  • Immunohistochemically, the tumor cells were positive for AE1/AE3, epithelial membrane antigen (EMA), and p16, but negative for CD10, inhibin-alpha, calretinin, vimentin, myogenin, and desmin, CD99,CgA, and Syn.
  • We review the previously published cases of endometrioid carcinomas of the fallopian tube resembling FATWO, and discuss the principal differential diagnosis of the tumor in the fallopian tube.
  • [MeSH-major] Endometrial Neoplasms / pathology. Fallopian Tube Neoplasms / pathology. Neoplasms, Adnexal and Skin Appendage / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19457622.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 23
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7. Thomassin-Naggara I, Daraï E, Cuenod CA, Fournier L, Toussaint I, Marsault C, Bazot M: Contribution of diffusion-weighted MR imaging for predicting benignity of complex adnexal masses. Eur Radiol; 2009 Jun;19(6):1544-52
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  • [Title] Contribution of diffusion-weighted MR imaging for predicting benignity of complex adnexal masses.
  • The purpose of this study was to prospectively assess the contribution of diffusion-weighted MR imaging (DWI) for characterizing complex adnexal masses.
  • Seventy-seven women (22-87 years old) with complex adnexal masses (30 benign and 47 malignant) underwent MR imaging including DWI before surgery.
  • ADC measurements did not contribute to differentiating benign from malignant adnexal masses.
  • All masses that displayed simultaneously low signal intensity within the solid component on T2-weighted and on b(1,000) diffusion-weighted images were benign.
  • Alternatively, the presence of a solid component with intermediate T2 signal and high b(1,000) signal intensity was associated with a PLR of 4.5 for a malignant adnexal tumour.
  • DWI signal intensity is an accurate tool for predicting benignity of complex adnexal masses.
  • [MeSH-major] Adnexal Diseases / diagnosis. Diffusion Magnetic Resonance Imaging / methods

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  • (PMID = 19214523.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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8. Petersson F, Kutzner H, Spagnolo DV, Bisceglia M, Kacerovska D, Vazmitel M, Michal M, Kazakov DV: Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2009 Oct;31(7):642-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spiradenoma is a benign, morphologically well-defined cutaneous adnexal neoplasm that is closely related to cylindroma.
  • Although well-developed bilayered glands with a demonstrable peripheral myoepithelial cell layer were not recognizable in the ACC-like areas, immunohistochemistry demonstrated myoepithelial differentiation in these portions of the tumors.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19633533.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Ramos-Ceballos FI, Pashaei S, Kincannon JM, Morgan MB, Smoller BR: Bcl-2, CD34 and CD10 expression in basaloid follicular hamartoma, vellus hair hamartoma and neurofollicular hamartoma demonstrate full follicular differentiation. J Cutan Pathol; 2008 May;35(5):477-83
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  • BFH is a benign adnexal tumor that resembles basal cell carcinoma (BCC).
  • In this study, we report two cases of GBFHS and stain BFH, a vellus hair hamartoma (VHH) and a neurofollicular hamartoma (NH) with CD34, bcl-2 and CD10 to characterize and compare the staining patterns of these follicular tumors.
  • Bcl-2 stains the outermost cell layer of these tumors.
  • These results show the similarities in differentiation between these benign follicular neoplasms and trichoepithelioma.

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  • [CommentIn] J Cutan Pathol. 2009 May;36(5):603; author reply 604 [19476535.001]
  • (PMID = 18399809.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers; 0 / Proto-Oncogene Proteins c-bcl-2; EC 3.4.24.11 / Neprilysin
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10. Yazbek J, Ameye L, Timmerman D, Testa AC, Valentin L, Holland TK, Van Holsbeke C, Jurkovic D: Use of ultrasound pattern recognition by expert operators to identify borderline ovarian tumors: a study of diagnostic performance and interobserver agreement. Ultrasound Obstet Gynecol; 2010 Jan;35(1):84-8
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  • [Title] Use of ultrasound pattern recognition by expert operators to identify borderline ovarian tumors: a study of diagnostic performance and interobserver agreement.
  • OBJECTIVE: To assess the accuracy and reproducibility of ultrasound 'pattern recognition' for the diagnosis of borderline ovarian tumors by asking experienced ultrasound operators to evaluate representative images of different types of adnexal tumor.
  • METHODS: Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed by three expert sonologists who had not performed the original real-time ultrasound examination.
  • The outcome measures included diagnostic accuracy and interobserver agreement in the diagnosis of benign, borderline or invasive malignant ovarian tumors.
  • A correct classification was made by all three experts in 83% of the primary invasive cancers, 76% of the benign masses and in 44% of the borderline malignant tumors (P < 0.01).
  • The experts showed a tendency to misclassify borderline tumors as benign rather than primary invasive (ratio of 8 : 1 for Expert A, 4 : 1 for B and 6 : 1 for C).
  • The interobserver agreement between any two experts was very good when they were tested for their ability to discriminate between invasive and non-invasive (benign and borderline) ovarian tumors (Cohen's kappa 0.85-0.88), but poorer for the discrimination between malignant (invasive and borderline) and benign tumors (kappa 0.70-0.78).
  • CONCLUSIONS: The accuracy of ultrasound diagnosis of borderline tumors is lower in comparison with benign and invasive malignant lesions.
  • The diagnostic performance and interobserver agreement are better when the outcomes are dichotomized into non-invasive and invasive malignant lesions, as opposed to the traditional diagnosis of benign and malignant tumors.
  • [MeSH-major] Adnexal Diseases / ultrasonography. Ovarian Neoplasms / ultrasonography. Pattern Recognition, Visual

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  • (PMID = 19746450.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Lin WL, Lin WC, Kuo TT, Chen CH, Hong HS: An unusual complex cutaneous adnexal tumor composed of syringocystadenoma papilliferum, apocrine hidrocystoma, and clear cell syringoma. Dermatol Surg; 2007 Jul;33(7):876-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual complex cutaneous adnexal tumor composed of syringocystadenoma papilliferum, apocrine hidrocystoma, and clear cell syringoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Facial Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17598859.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Moszyński R, Szpurek D, Pawlak M, Englert-Golon M, Sajdak S: [The influence of ovarian tumour histopathological diagnosis on prognostic values of the sonomorphological index]. Ginekol Pol; 2006 Jul;77(7):516-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The influence of ovarian tumour histopathological diagnosis on prognostic values of the sonomorphological index].
  • OBJECTIVES: The purpose of the study was to evaluate the helpfulness of sonomorphological index in preoperative diagnosis of ovarian tumours.
  • MATERIAL AND METHOD: 686 patients diagnosed and treated because of adnexal tumours were analyzed.
  • At the admission day the patient underwent an ultrasonographical examination that stated morphology of tumour using the sonomorphological index (SM).
  • During the study, histopathological types of ovarian tumours with the lowest prognostic values were appointed.
  • Among malignant tumours the lowest sensitivity of the test corresponded with: dysgerminoma and folliculoma.
  • Among benign tumours the lowest helpfulness in preoperative diagnosis of ovarian tumours the sonomorphological index demonstrated in following histopathological types: mucinouse cystadenoma and adult teratoma.
  • CONCLUSIONS: In all histopathological types of malignant and benign tumours mentioned above, the use of the sonomorphological index require caution.

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  • (PMID = 17076201.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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13. Parma P, Dall'Oglio B, Samuelli A, Bondavalli C, Bellomi A: [Laparoscopic removal of voluminous right seminal vesicle neoplasm]. Urologia; 2010 Oct-Dec;77 Suppl 17:46-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: We present the case of a male adnexal tumor of probable Wolffian origin occurred to the right seminal vesicle of a 47-year-old man.
  • RESULTS: The right seminal vesicle, along with the tumor and the right vas deferens, were excised and clear margins were ensured by frozen section.
  • The histologic examination demonstrated a male adnexal tumor of probable Wolffian origin, which is a rare low-grade malignant neoplasm that has been previously described in the broad ligament, ovaries and retroperitoneum of females.
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adnexal Diseases / complications. Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Adnexal Diseases / surgery. Biopsy. Diagnosis, Differential. Hemospermia / etiology. Humans. Male. Middle Aged. Tomography, X-Ray Computed. Vas Deferens / surgery

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  • (PMID = 21308675.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Wolffian tumor
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14. Gaffar M, Thebpatiphat N, Przygodzki R, Jacobs S, Miller MM: Primary follicular lymphoma of the conjunctiva in a 6-year-old child. J AAPOS; 2010 Dec;14(6):538-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ocular adnexal tumors are rare.
  • We report the case of a 6-year-old boy with a 3-mm conjunctival mass.

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  • [Copyright] Copyright © 2010 American Association for Pediatric Ophthalmology and Strabismus. All rights reserved.
  • (PMID = 21093330.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Iura A, Sasajima Y, Katsumata N, Kasamatsu T: Serous adenocarcinoma of the retroperitoneum, as a type of multifocal müllerian carcinoma. Int J Clin Oncol; 2009 Jun;14(3):254-7
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  • On MRI, the tumor was 17 x 10 x 6 cm in size and monocystic.
  • The tumor cells were positive for CA125, estrogen receptor, and Wilms tumor 1, and were differentiated from enterogenic cyst by the presence of cytokeratin 7 (+), and the absence of cytokeratin 20 (-).
  • Simultaneously, uterine adnexal serous adenocarcinoma was detected.
  • The volume of the retroperitoneal tumor was 14 times larger than that of the uterine adnexal tumor.
  • We suggest the possibility that the retroperitoneal cancer arose as a primary cancer from rests of the müllerian epithelium synchronously with the uterine adnexal cancer.
  • The patient had been taking conjugated estrogen for 10 years, suggesting that long-term estrogen stimulation may have contributed to the progression of the tumors.
  • [MeSH-major] Adnexa Uteri / pathology. Cystadenocarcinoma, Serous / pathology. Mullerian Ducts / pathology. Peritoneal Neoplasms / pathology

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  • [Cites] Histopathology. 2002 Feb;40(2):171-6 [11952862.001]
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  • (PMID = 19593619.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. González-Vela MC, Val-Bernal JF, Garcia-Alberdi E, González-López MA, Fernández-Llaca JH: Trichoadenoma associated with an intradermal melanocytic nevus: a combined malformation. Am J Dermatopathol; 2007 Feb;29(1):92-5
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  • Melanocytic nevi have been associated with epidermal hyperplasia, adnexal hyperplasia with follicular and sebaceous differentiation, cysts, and tumors of epidermal or adnexal origin.
  • Clinical diagnosis was a malignant transformation of a melanocytic nevus.
  • Although to our knowledge this association has not been previously reported, it is worth considering that trichoadenoma and desmoplastic trichoepithelioma are the two ends of a spectrum of lesions.
  • This combined hamartoma reported herein is important because growth of these lesions could be clinically misinterpreted as malignant transformation of a preexisting lesion.
  • [MeSH-major] Adenoma / pathology. Hamartoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 17284971.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Siddiqui NH, Wu SJ: Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report. Diagn Cytopathol; 2005 Apr;32(4):229-32
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  • [Title] Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report.
  • Here, we present a case of a 70-yr-old man with an asymptomatic left deep lobe parotid mass for which CT-guided FNAB was performed.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754364.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Kinkor Z, Skálová A, Michal M, Janousek M, Kheck M: [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. Ceska Gynekol; 2005 May;70(3):211-6
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  • RESULTS: Partial mastectomy and segmentectomy were performed in three women 46, 72 and 74 years-old resp. for tumor, which size ranged from 20-35 mm in maximum diameter (mean 28 mm).
  • There were recognized metastases by one woman in two ipsilateral axillary lymph nodes mimicking benign breast heterotopia in one of them.
  • In two women with aggressive course the original biopsy was falsely interpreted, once as phyllodes tumor and secondly as benign sclerosing pseudotumor.
  • It arises in the deep breast tissue and structurally resembles the microcystic adnexal carcinoma of the skin.
  • Low-grade adenosquamous carcinoma, however, has nothing to do with syringomatous adenoma of the nipple, which is a benign tumor of the skin adnexa.
  • Differential diagnosis includes spectrum of non-neoplastic slerosing lesions and above-mentioned phylloid tumor.


19. Veyer L, Marret H, Bleuzen A, Simon E, Body G, Tranquart F: Preoperative diagnosis of ovarian tumors using pelvic contrast-enhanced sonography. J Ultrasound Med; 2010 Jul;29(7):1041-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative diagnosis of ovarian tumors using pelvic contrast-enhanced sonography.
  • OBJECTIVE: The purpose of this study was to assess the feasibility of using a contrast agent for the sonographic examination of adnexal tumors and identify discriminating parameters in the preoperative diagnosis of malignant tumors.
  • Patients included were referred for a second opinion after the discovery of a suspicious ovarian image.
  • RESULTS: Fifty-two tumors were analyzed.
  • Morphologic and Doppler criteria analyses were conducted as described in the literature.
  • When borderline tumors were eliminated, there was an inversion of this, with an AUC of 0.85 versus 0.73.
  • The inclusion of contrast results in the examiner's diagnosis in the context of a bivariate model comparing malignant and borderline tumors with benign tumors provided an AUC of 0.88.
  • CONCLUSIONS: Contrast-enhanced sonography improves preoperative diagnosis of ovarian tumors parameters.
  • The significant parameters of the enhancement curve were significantly different for malignant and benign tumors.
  • Borderline tumors contribute to a reduction of the discriminating capacity of the contrast agent.

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  • (PMID = 20587427.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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20. Nishikawa Y, Kaneko T, Takiyoshi N, Aizu T, Nakajima K, Matsuzaki Y, Nakano H, Sawamura D: Dermoscopy of eccrine poroma with calcification. J Dermatol Case Rep; 2009 Nov 28;3(3):38-40
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  • BACKGROUND: Eccrine poromas are relatively common slow-growing benign solitary adnexal tumors originating from the intraepidermal portion of the eccrine sweat duct (acrosyringium).
  • MAIN OBSERVATIONS: A 73-year-old man with hemiparesis, who had a 10-year history of tumor on his right palm, which was occasionally injured by a walking crutch, causing bleeding and ulceration.
  • Physical examination revealed a pigmented dome-shaped tumor.
  • Histological examination revealed that the tumor was composed of cords of tumor cells extending from the epidermis into the dermis.
  • The tumor showed cystic structures and calcification.
  • CONCLUSIONS: Although cutaneous neoplasms commonly associated with calcification are of follicular origin, it is known that dystrophic calcification may be triggered also in tumors of eccrine origin by multiple factors, including mechanical injury.

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  • [Cites] Br J Dermatol. 2001 Jan;144(1):146-50 [11167697.001]
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  • (PMID = 21886728.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157797
  • [Keywords] NOTNLM ; Pinkus type / adnexal tumors / calcification / dermoscopy / eccrine gland / local tissue injury
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21. Kim JY, Kim YC, Lee ES: Solitary eccrine syringofibroadenoma with prominent plasma cell infiltration. J Dermatol; 2007 Feb;34(2):138-41
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  • Eccrine syringofibroadenoma (ESFA) is a rare, benign, adnexal neoplasm thought to be eccrine ductal differentiation displaying variable clinical findings and characteristic histological features.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Plasma Cells / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17239154.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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22. Kupesic S, Plavsic BM: Early ovarian cancer: 3-D power Doppler. Abdom Imaging; 2006 Sep-Oct;31(5):613-9
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  • Color Doppler imaging and pulsed Doppler spectral analysis enable evaluation of ovarian tumor blood flow, analysis of the distribution of blood vessels, and quantitative measurement of blood flow velocity waveforms.
  • These parameters increase the sensitivity and specificity of ultrasound evaluation of ovarian tumors.
  • Three-dimensional (3-D) power Doppler ultrasound provides a new tool to evaluate features of tumor vascularity.
  • Contrast-enhanced 3-D power Doppler sonography facilitates visualization of adnexal tumor vessels, which may aid in differentiating benign from malignant adnexal lesions.

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  • (PMID = 16447081.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 44
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23. Giger O, Caduff R, O'Meara A, Diener PA, Knuth A, Jäger D, Moch H, Varga Z: Frequent expression of the breast differentiation antigen NY-BR-1 in mammary and extramammary Paget's disease. Pathol Int; 2010 Nov;60(11):726-34
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  • Recently NY-BR-1, a differentiation antigen expressed in the breast and in skin adnexal structures was identified.
  • Its protein expression is restricted to normal and neoplastic breast epithelium and to adnexal tumors of the skin.

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  • [Copyright] © 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 20946522.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / breast cancer antigen NY-BR-1, human
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24. Schmidt LA, Olsen SH, McHugh JB: Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy. Am J Surg Pathol; 2010 Aug;34(8):1205-10
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  • [Title] Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy.
  • Cutaneous adnexal differentiation is well-recognized in benign mixed tumors occurring in cutaneous sites.
  • We sought to describe the incidence of cutaneous adnexal differentiation in benign mixed tumors of the palate, lip, and parotid gland.
  • Benign mixed tumors of the palate (n=30), lip (n=13), and parotid gland (n=37) resected between 1980 and 2009 at a single academic medical institution were reviewed.
  • After confirming the diagnosis of benign mixed tumor, we evaluated for morphologic evidence of cutaneous adnexal differentiation and metaplastic epithelial and stromal changes.
  • Cutaneous adnexal differentiation was seen in 20% of palate and 39% of lip benign mixed tumors but in no parotid tumors.
  • The most frequent features of cutaneous adnexal differentiation were tricholemmal differentiation (20% of palate and 39% of lip tumors), infundibulocystic structures (17% and 31%), and trichohyalin granules (13% and 31%).
  • Sebaceous differentiation was seen in only one palate tumor.
  • Varying amounts of stromal adipose were seen in 62, 37, and 22% of lip, palate, and parotid tumors.
  • Osseous metaplasia was seen in one tumor from each site.
  • When cutaneous adnexal differentiation occurs in salivary gland pleomorphic adenomas, it can present a diagnostic pitfall that must not be misinterpreted as carcinoma at biopsy, fine needle aspiration, or frozen section.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Cell Differentiation. Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Mouth Neoplasms / pathology. Stromal Cells / pathology

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  • (PMID = 20661019.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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25. Nogales FF, Stolnicu S, Harilal KR, Mooney E, García-Galvis OF: Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract. Histopathology; 2009 Mar;54(4):471-7
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  • [Title] Retiform uterine tumours resembling ovarian sex cord tumours. A comparative immunohistochemical study with retiform structures of the female genital tract.
  • AIMS: To analyse both the clinicopathological and immunohistochemical findings in six cases of uterine tumours resembling ovarian sex cord tumours with a predominant epithelial retiform component resembling the rete ovarii (RUTROSCT) and to compare their immunophenotype with tissues containing retiform structures such as the normal rete ovarii, retiform Wolffian adnexal tumour (RWAT) and ovarian retiform areas of Sertoli-Leydig cell tumours (ORSLCT).
  • The average age of patients was 65 years, and all tumours behaved in a benign fashion.
  • Histologically they had a tubulopapillary or glomeruloid formation; a sex-cord-like or endometrial stromal component was absent or comprised at most 30% of the tumour.
  • CONCLUSIONS: RUTROSCTs have benign behaviour but may be confused with various uterine adenocarcinomas or metastases.
  • [MeSH-major] Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology. Uterine Neoplasms / metabolism. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Calbindin 2. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Inhibins / metabolism. Keratin-7 / metabolism. Middle Aged. Mucin-1 / metabolism. Neprilysin / metabolism. S100 Calcium Binding Protein G / metabolism. Sertoli-Leydig Cell Tumor / metabolism. Sertoli-Leydig Cell Tumor / pathology

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  • [CommentIn] Histopathology. 2009 Nov;55(5):619-20; author reply 620-1 [19912370.001]
  • (PMID = 19309399.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Keratin-7; 0 / Mucin-1; 0 / S100 Calcium Binding Protein G; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.4.24.11 / Neprilysin
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26. Flores-Alvarez E, Tello-Brand SE, López-López F, Rivera-Barragán V: Peritoneal tuberculosis. Report of seven cases. Cir Cir; 2010 Jan-Feb;78(1):67-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most frequent clinical data were abdominal pain (six patients), ascites (four patients), and abdominal tumor (three patients).
  • Abdominopelvic CT examinations revealed unilateral ovarian tumor in four patients, bilateral ovarian tumor in two patients, ascites in four patients, and retroperitoneal adenopathy in one patient.
  • All patients had a preoperative diagnosis of malignant tumor.
  • Diagnoses should be considered in all patients with ascites, adnexal tumors and elevated serum CA-125 levels.

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  • (PMID = 20226130.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Antitubercular Agents; 0 / Biomarkers; 0 / CA-125 Antigen
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27. Goh SG, Carr R, Dayrit JF, Calonje E: Mucinous hidradenoma: a report of three cases. J Cutan Pathol; 2007 Jun;34(6):497-502
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  • Mucinous cutaneous adnexal tumors are an uncommon occurrence.
  • Case 2, from the shoulder of a 40-year-old man, was a 2.5-cm well-circumscribed nodule composed of hyperplastic villoglandular proliferation of mucinous cells with focal squamous whorls and focal columnar glandular cells showing decapitation secretion.
  • The tumor was also interpretated as a mucinous hidradenoma, most likely of follicular-apocrine origin.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cystadenoma, Mucinous / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17518780.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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28. Gupta R, Singh S, Gupta K, Kudesia M: Clear-cell hidradenoma in a child: a diagnostic dilemma for the cytopathologist. Diagn Cytopathol; 2009 Jul;37(7):531-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary cutaneous tumors are infrequently subjected to fine needle aspiration cytology.
  • As a result, the cytological reports of skin adnexal tumors like hidradenoma are scarce in the available literature.
  • The cytological features, in conjunction with the clinical examination, suggested a skin appendageal tumor.
  • Though nuclear pleomorphism and occasional larger nucleus posed a cytological diagnostic challenge, a diagnosis of benign appendageal tumor was suggested, considering the young age of the patient.
  • The cytopathologist should consider skin appendageal tumors during evaluation of cutaneous nodules.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Skin Neoplasms / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19459171.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Cabral ES, Auerbach A, Killian JK, Barrett TL, Cassarino DS: Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry. Am J Dermatopathol; 2006 Dec;28(6):465-71
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  • [Title] Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry.
  • Sebaceous lesions, including sebaceous hyperplasia, sebaceomas, and sebaceous adenomas and carcinomas, are histologically distinctive adnexal proliferations with a spectrum of biological behavior ranging from benign to frankly malignant.
  • We studied multiple oncogenic and therapeutic related proteins by immunohistochemistry to identify differences in expression between benign and malignant sebaceous proliferations.
  • [MeSH-major] Biomarkers, Tumor / analysis. Facial Neoplasms / chemistry. Sebaceous Gland Neoplasms / chemistry. Sebaceous Glands / chemistry
  • [MeSH-minor] Adenocarcinoma, Sebaceous / chemistry. Adenoma / chemistry. Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p21 / analysis. Female. Humans. Hyperplasia. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptor, ErbB-2 / analysis. Tumor Suppressor Protein p53 / analysis


30. Fullen DR, Garrisi AJ, Sanders D, Thomas D: Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays. J Cutan Pathol; 2008 Nov;35 Suppl 2:28-34
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  • [Title] Expression of S100A6 protein in a broad spectrum of cutaneous tumors using tissue microarrays.
  • BACKGROUND: S100A6, a calcium-binding protein in the S100 family, has been observed in melanocytic nevi, neural tumors, fibrohistiocytic tumors and is overexpressed in melanoma.
  • Limited data on S100A6 expression in cutaneous epithelial tumors exists in the literature.
  • The goal of this study was to determine the specificity and sensitivity of S100A6 protein in a spectrum of cutaneous mesenchymal or epithelial tumors.
  • METHODS: Tissue microarrays of cutaneous epithelial neoplasms, mesenchymal neoplasms, DM and malignant peripheral nerve sheath tumors (MPNST) were stained with S100A6 antibody.
  • Four of seven microcystic adnexal carcinomas (MAC) stained for S100A6.
  • Tumors with duct differentiation variously expressed S100A6 protein, with two hidradenomas showing the strongest staining.
  • Malignant spindle cell tumors, with the exception of 13 of 30 MPNST, had a high incidence of S100A6 positivity.
  • CONCLUSIONS: S100A6 expression may distinguish SCC from BCC, MAC from BCC and hidradenoma from other adnexal tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cell Cycle Proteins / biosynthesis. S100 Proteins / biosynthesis. Skin Neoplasms / diagnosis. Skin Neoplasms / metabolism
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Diagnosis, Differential. Humans. Melanoma / diagnosis. Melanoma / metabolism. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / metabolism. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / metabolism. Tissue Array Analysis

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  • (PMID = 18201235.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / S100 Proteins; 105504-00-5 / S100A6 protein, human
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31. Franzin CM, Marussi EF, Zeferino LC, Sarian LO, Prada MF: [Association between sonographic findings and histological diagnosis of 446 ovarian tumors]. Rev Assoc Med Bras (1992); 2006 May-Jun;52(3):176-81
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  • [Title] [Association between sonographic findings and histological diagnosis of 446 ovarian tumors].
  • [Transliterated title] Correlação entre as características ultra-sonográficas e o diagnóstico histológico de 446 tumores ovarianos.
  • Patients who had been submitted to surgery due to uni or bilateral ovarian tumors were included and those presenting with an ectopic pregnancy or pelvic inflammatory process were excluded.
  • The magnitude of the associations between pathology diagnoses and sonographic morphologic findings where estimated by the Odds Ratio with its respective confidence intervals of 95%.
  • RESULTS: In their majority, masses were benign tumors (88.1%).
  • CONCLUSION: Sonographic analyses of adnexal tumors having more than 7 cm of diameter, irregular and poorly delimited external borders, presenting complex or anechoic textures with thickened septa or solid mass are highly suggestive of malignancy.

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  • (PMID = 16847525.001).
  • [ISSN] 0104-4230
  • [Journal-full-title] Revista da Associação Médica Brasileira (1992)
  • [ISO-abbreviation] Rev Assoc Med Bras (1992)
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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32. Yazbek J, Ameye L, Testa AC, Valentin L, Timmerman D, Holland TK, Van Holsbeke C, Jurkovic D: Confidence of expert ultrasound operators in making a diagnosis of adnexal tumor: effect on diagnostic accuracy and interobserver agreement. Ultrasound Obstet Gynecol; 2010 Jan;35(1):89-93
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  • [Title] Confidence of expert ultrasound operators in making a diagnosis of adnexal tumor: effect on diagnostic accuracy and interobserver agreement.
  • OBJECTIVE: To assess the degree of confidence with which expert ultrasound operators make a diagnosis of benign, borderline and invasive malignant ovarian tumors and its effect on diagnostic accuracy and interobserver agreement.
  • METHOD: Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed by three expert ultrasound operators who had not performed the original real-time ultrasound examination.
  • The experts classified the tumors as benign, borderline or invasive malignant and they also indicated the degree of confidence with which they made the diagnosis (certain, probable and uncertain).
  • The diagnostic accuracy and interobserver agreement, in differentiating benign, borderline and invasive malignant ovarian tumors, were calculated depending on the level of confidence with which the diagnosis was made.
  • The agreement in both diagnosis and confidence was lowest in cases of borderline ovarian tumors compared to benign and primary invasive lesions.
  • [MeSH-major] Adnexal Diseases / ultrasonography. Ovarian Neoplasms / ultrasonography

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  • (PMID = 19757401.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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33. Manikandan R, Khafagy R, Reeve R, Agarwal M, Clarke NW: Male adnexal tumour of probable Wolffian duct origin. Scand J Urol Nephrol; 2005;39(6):520-2
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  • [Title] Male adnexal tumour of probable Wolffian duct origin.
  • Male adnexal tumours of Wolffian duct origin are very rare.
  • We report the case of a 56-year-old male who presented with a swelling in the perineum thought to be a haematoma as the result of a complication of a laparoscopic inguinal hernia repair.
  • Histology revealed the lesion to be an adnexal tumour of probable Wolffian duct origin.
  • To our knowledge there have only been two previous cases of male adnexal tumour of Wolffian duct origin reported in the literature.

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  • (PMID = 16303731.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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34. Bai WP, Li LP, Feng MY, Wang XH, Qin XQ, Li KM, Zhou YF: [Clinical comparison of transvaginal hysterectomy and laparoscopic hysterectomy]. Zhonghua Fu Chan Ke Za Zhi; 2005 Oct;40(10):656-8
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  • The ratio of adenoma (29.44%), adnexal disease (4.55%), pelvic endometriosis (4.06%), history of cesarean section (7.11%) in TVH were lower than that in TLH (43.27%, 31.73%, 12.50%, 24.04%).
  • The operation time (76 +/- 28) minutes, bleeding during operation (170 +/- 125) ml, additional operations (5.08%), pelvic adhesion (4.57%), loosening of pelvic adhesion (0.51%), the diameter of the largest myoma or adenoma (49 +/- 17) mm, expenses for operation and hospitalization (1073 +/- 203) yuan in TVH were lower than those in TLH, which were (139 +/- 52) minutes, (206 +/- 153) ml, 36.54%, 41.35%, 17.31%, (57 +/- 22) mm, (1526 +/- 676) yuan respectively.
  • CONCLUSIONS: TVH is recommended in cases of few pelvic adhesion, or adnexal disease, cervical disease and of multipara.

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  • (PMID = 16277892.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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35. Mataix J, Bañuls J, Botella R, Laredo C, Lucas A: [Brooke-Spiegler syndrome: an heterogeneous entity]. Actas Dermosifiliogr; 2006 Dec;97(10):669-72
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  • [Transliterated title] Síndrome de Brooke-Spiegler: una entidad heterogénea.
  • The Brooke-Spiegler syndrome is a rare, autosomally dominant disease with a predisposition to develop different adnexal tumors.
  • In this article we present the case of a woman and her daughter, both affected by this rare genodermatosis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Neoplasms, Basal Cell / genetics. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 17173833.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / CYLD protein, human; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 30
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36. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Transliterated title] Siringoma condroide: revisión clínica e histológica de ocho casos.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • RESULTS: Most of the cases occurred as well-defined nodular lesions, whose presumptive clinical diagnosis was adnexal or cystic pathology.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • The final treatment of these tumors is surgical.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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37. Triaridis S, Papadopoulos S, Tsitlakidis D, Printza A, Grosshans E, Cribier B: Trichoblastic carcinoma of the pinna. A rare case. Hippokratia; 2007 Apr;11(2):89-91
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  • Adnexal tumors of the hair follicle can be regarded as lesions that show similar differentiation to one or more portions of the hair follicle.
  • Trichoblastic carcinoma is a rare malignant adnexal tumor, which usually occurs on the scalp.
  • We report a case of a 65 years old man with a painless irregular mass of the posterior surface of the right pinna, which was slowly growing over a 5-year period.
  • He had a history of a similar lesion on the same site, which was removed 8 years before he presented to us.

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  • [Cites] Acta Derm Venereol. 1998 May;78(3):173-6 [9602220.001]
  • [Cites] Indian J Cancer. 1989 Mar;26(1):1-9 [2777327.001]
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  • (PMID = 19582185.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2464267
  • [Keywords] NOTNLM ; malignant pilar tumor / pilar carcinoma / trichoblastic carcinoma
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38. Lennerz JK, Perry A, Dehner LP, Pfeifer JD, Lind AC: CRTC1 rearrangements in the absence of t(11;19) in primary cutaneous mucoepidermoid carcinoma. Br J Dermatol; 2009 Oct;161(4):925-9
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  • BACKGROUND: Mucoepidermoid carcinoma (MEC) of the skin is an uncommon neoplasm with a remarkable resemblance to MEC of the salivary glands.
  • Two MECs metastatic to the skin, histologically identical to primary cutaneous MEC, were included, one of which harboured the CRTC1-MAML2 fusion gene by RT-PCR, verified by interphase FISH and sequencing.
  • CONCLUSIONS: MEC of the skin harbours CRTC1 rearrangements, a molecular finding that reflects morphological similarities between glandular and cutaneous MEC.
  • The absence of oncogenic t(11;19) or MAML2 aberrations in our series, which is the largest reported, may explain the innocuous clinical behaviour of this uncommon adnexal tumour.
  • [MeSH-major] Carcinoma, Mucoepidermoid / genetics. Gene Rearrangement / genetics. Neoplasm Proteins / genetics. Oncogene Proteins, Fusion / genetics. Skin Neoplasms / genetics. Transcription Factors / genetics

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  • (PMID = 19438452.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factors
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39. Kazakov DV, Vanecek T, Belousova IE, Mukensnabl P, Kollertova D, Michal M: Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast. Am J Dermatopathol; 2007 Oct;29(5):457-61
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  • [Title] Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast.
  • Skin adnexal type tumors situated in the parenchyma of the breast are very rare.
  • The tumor was situated in the parenchyma of the breast of a 55-year-old female and showed no connection to the overlying skin on ultrasound and radiology investigations, grossly and microscopically.
  • Histologically, the tumor was identical to its cutaneous counterpart and was surrounded by breast tissue.
  • Several mammary ducts in close proximity to the tumor showed features of columnar cell hyperplasia.
  • This t(11;19) translocation has been reported in approximately 50% of hidradenomas of the skin.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Breast Neoplasms / genetics. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Translocation, Genetic / genetics

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  • (PMID = 17890914.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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40. Torres A, Torres K, Paszkowski T, Staśkiewicz G, Maciejewski R, Woźniakowska E, Zaleska W: [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy]. Ginekol Pol; 2007 Oct;78(10):764-7
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  • [Title] [Concentration of TNF-alpha in the postoperative period in patients with benign adnexal tumors treated by laparoscopy or laparotomy].
  • OBJECTIVES: The aim of the study was to compare serum concentrations of the TNF-alpha (TNF-alpha) in the early postoperative period in patients with benign adnexal masses operated by laparoscopy or laparotomy.
  • MATERIAL AND METHODS: The study was conducted in a group of patients aged from 20 to 52, operated due to adnexal masses.
  • CONCLUSIONS: Lower concentrations of TNF-alpha in the laparoscopy group, observed 24 hours after the operation, may reflect more favorable changes in the systemic inflammatory response after minimally invasive management of benign ovarian masses.
  • [MeSH-major] Biomarkers, Tumor / blood. Laparoscopy. Laparotomy. Ovarian Diseases / blood. Ovarian Diseases / surgery. Postoperative Period. Tumor Necrosis Factor-alpha / blood
  • [MeSH-minor] Adnexal Diseases / blood. Adnexal Diseases / surgery. Adult. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasms, Adnexal and Skin Appendage / blood. Neoplasms, Adnexal and Skin Appendage / diagnosis. Neoplasms, Adnexal and Skin Appendage / surgery. Ovarian Neoplasms / blood. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / surgery. Treatment Outcome

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  • (PMID = 18200965.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Necrosis Factor-alpha
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41. Adamicová K, Fetisovová Z, Mellová Y, Výbohová D: [Diagnostic procedures in skin adnexal tumours]. Cesk Patol; 2006 Apr;42(2):59-65
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  • [Title] [Diagnostic procedures in skin adnexal tumours].
  • From histogenetic, morphologic and immunohistochemical point of view the authors try to make possible algorithms that can be employed in a routine diagnosis of adnexal skin tumours.
  • They stress the importance of knowledge of clinical data necessary for orientation classification of tumour skin lesions after biopsies.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / diagnosis

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  • (PMID = 16715628.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] slo
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 33
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42. Nelson PS, Bourgeois KM, Nicotri T Jr, Chiu ES, Poole JC: Sclerosing sweat duct carcinoma in a 6-year-old African American child. Pediatr Dermatol; 2008 Jan-Feb;25(1):38-42
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  • Sclerosing sweat duct carcinoma is a rare, locally aggressive adnexal tumor that frequently occurs on the face of middle-aged adults, invades deeply, and has a propensity to recur.
  • [MeSH-major] African Americans. Carcinoma, Skin Appendage / ethnology. Carcinoma, Skin Appendage / pathology. Neoplasm Invasiveness / pathology. Sweat Gland Neoplasms / ethnology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18304151.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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43. Nezhat FR, Ezzati M, Chuang L, Shamshirsaz AA, Rahaman J, Gretz H: Laparoscopic management of early ovarian and fallopian tube cancers: surgical and survival outcome. Am J Obstet Gynecol; 2009 Jan;200(1):83.e1-6
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  • STUDY DESIGN: Case series conducted at the University Hospital with 36 patients who had presumed early-stage adnexal cancers.
  • RESULTS: Cases included 20 invasive epithelial tumors, 11 borderline tumors, and 5 nonepithelial tumors.
  • CONCLUSION: This represents 1 of the largest series and longest follow-ups of laparoscopic staging for early-stage adnexal tumors.

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  • (PMID = 19019337.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Târcoveanu E, Dimofte G, Niculescu D, Vasilescu A, Moldovanu R, Ferariu D, Marcovici I: Ovarian fibroma in the era of laparoscopic surgery: a general surgeon's experience. Acta Chir Belg; 2007 Nov-Dec;107(6):664-9
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  • The ovarian fibroma is a rare benign tumor originating from the connective tissue of the ovarian cortex.
  • Only four cases required emergency operations due to either tumors or adnexal torsion.
  • Surgical treatment consisted of five ovarectomies, three adnexal resections and five total hysterectomies with bilateral salpingo-oophorectomy.

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  • (PMID = 18274181.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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45. Liu WM, Wang PH, Chia CC: A feasible laparoscopic surgery technique for complex adnexal tumors. Taiwan J Obstet Gynecol; 2007 Jun;46(2):185-6; author reply 186
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  • [Title] A feasible laparoscopic surgery technique for complex adnexal tumors.
  • [MeSH-major] Adnexa Uteri / surgery. Laparoscopy / methods. Ovarian Neoplasms / surgery. Uterine Neoplasms / surgery

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  • [CommentOn] Taiwan J Obstet Gynecol. 2007 Mar;46(1):83-4 [17389199.001]
  • (PMID = 17638632.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] China
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46. Park HJ, Lee DY, Lee JH, Yang JM, Lee ES, Kim WS: The treatment of syringomas by CO(2) laser using a multiple-drilling method. Dermatol Surg; 2007 Mar;33(3):310-3
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  • BACKGROUND: Syringomas are relatively common benign adnexal tumors, predominantly developing in middle-aged women.
  • OBJECTIVES: The objective of this study was to determine the effectiveness of a multiple-drilling method in the treatment of syringomas.

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  • (PMID = 17338688.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
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47. Karaca M, Sevinc A, Aydin A, Gocmen A, Buyukberber S, Camci C, Sari I: Female adnexal tumor of probable Wolffian origin diagnosed during the staging evaluation of extranodal diffuse large B-cell lymphoma. Leuk Lymphoma; 2005 Jun;46(6):929-33
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  • [Title] Female adnexal tumor of probable Wolffian origin diagnosed during the staging evaluation of extranodal diffuse large B-cell lymphoma.
  • Female adnexal tumor of probable Wolffian origin (FATPWO) is a rare neoplasm arising within the leaves of broad ligament or hanging from it or a fallopian tube.
  • [MeSH-major] Lymphoma, B-Cell / diagnosis. Lymphoma, Large B-Cell, Diffuse / diagnosis. Neoplasms, Adnexal and Skin Appendage / diagnosis. Wolffian Ducts / pathology

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  • (PMID = 16019541.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Topuz S, Saygili H, Akhan S, Yavuz E, Turfanda A, Berkman S: Differentiation of benign and malignant adnexal masses: value of a morphologic scoring system. Eur J Gynaecol Oncol; 2005;26(2):209-12
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  • [Title] Differentiation of benign and malignant adnexal masses: value of a morphologic scoring system.
  • OBJECTIVE: The purpose of this study was to assess the value of conventional gray-scale ultrasonography, based on a morphologic scoring system, in the differential diagnosis of malignant and benign adnexal tumors.
  • MATERIAL AND METHODS: A total of 58 adnexal masses in 51 patients were classified prospectively as suggestive of malignant or benign, on the basis of gray-scale ultrasonographic morphology.
  • RESULTS: Histopathology of 42 masses was found to be benign and 16 masses were found to be malignant.
  • On gray-scale analysis 15 of 16 malignant masses were classified as suggestive of malignant and 37 of 42 benign masses were classified as suggestive of benign.
  • However further investigations about the assessment of adnexal masses with ultrasonography are needed
  • [MeSH-major] Adnexal Diseases / ultrasonography. Neoplasms / ultrasonography

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  • (PMID = 15857033.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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49. Rescinito G, Sirlin C, Cittadini G Jr: Body MRI artefacts: from image degradation to diagnostic utility. Radiol Med; 2009 Feb;114(1):18-31
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  • [MeSH-minor] Abdomen. Adenoma / diagnosis. Adnexal Diseases / diagnosis. Adrenal Gland Neoplasms / diagnosis. Cysts / diagnosis. Fatty Liver / diagnosis. Female. Focal Nodular Hyperplasia / diagnosis. Humans. Male. Movement. Pelvis. Pulsatile Flow

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  • (PMID = 18836865.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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50. Lesin J, Forko-Ilić J, Plavec A, Planinić P: Management of Wolffian duct tumor recurrence without chemotherapy. Arch Gynecol Obstet; 2009 Nov;280(5):855-7
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  • [Title] Management of Wolffian duct tumor recurrence without chemotherapy.
  • BACKGROUND: A female adnexal tumor of probable Wolffian origin (FATWO) is a rare neoplasm which is considered to have a low malignant potential.
  • CASE: In 2006, a 60-year-old patient was admitted to hospital with solid tumor on the vaginal cuff confirmed by abdominal/pelvic CT, 6 years after her first FATWO was diagnosed and hysterectomy, bilateral adnexectomy, and omentectomia were done.
  • Pelvic washings, lysis of adhesions, and excision of tumor mass were performed.
  • Pathologic examination revealed malignant epithelial neoplasm of Wolffian origin with morphologic features similar to those of the patient's prior tumor.

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  • (PMID = 19288122.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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51. Silva CS, Souza MB, Lima KA, de Almeida MA, Criado PR: [Generalized eruptive syringoma: case report]. Dermatol Online J; 2009;15(2):7
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  • [Transliterated title] Siringoma eruptivo disseminado: Relato de caso.
  • Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts.
  • Clinically, they usually appear as small yellow or skin-colored papules ranging from 1-3 mm in diameter on the lower eyelids.
  • [MeSH-major] Skin / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19336024.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 22
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52. Craver R, Ward K, Heinrich S: Congenital subcutaneous dendritic cell rich lymphoepithelial hamartoma. Fetal Pediatr Pathol; 2005 Jul-Oct;24(4-5):255-65
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  • We present the clinical, radiologic, histologic, immunohistochemical, and ultrastructural characteristics of a congenital pretibial subcutaneous lesion composed of a mixture of T and B cells, epithelial cells, and dendritic cells, probably representing a hamartoma.
  • The prominent dendritic component of this lesion, demonstrated immunohistochemically and ultrastructurally, separates the lesion from cutaneous lymphadenoma and other adnexal tumors.
  • [MeSH-major] Dendritic Cells / pathology. Hamartoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] B-Lymphocytes / metabolism. B-Lymphocytes / pathology. B-Lymphocytes / ultrastructure. Cysts / pathology. Diagnosis, Differential. Epithelial Cells / metabolism. Epithelial Cells / pathology. Epithelial Cells / ultrastructure. Humans. Immunohistochemistry. Infant. Lipoma / pathology. Male. Microscopy, Electron, Transmission. Neoplasms, Adnexal and Skin Appendage / pathology. T-Lymphocytes / metabolism. T-Lymphocytes / pathology. T-Lymphocytes / ultrastructure

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  • (PMID = 16396831.001).
  • [ISSN] 1551-3815
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Krahl D, Sellheyer K: p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology. Br J Dermatol; 2010 Jul;163(1):138-45
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  • [Title] p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology.
  • BACKGROUND: Tumour development is frequently described in the basic pathology literature as a recapitulation of embryogenesis.
  • However, a link between the embryology of the skin and the histogenesis of adnexal tumours has been largely overlooked.
  • We therefore speculated that it is involved in the histogenesis of follicular adnexal tumours.
  • In contrast, the lack of p75NTR expression in morphoeic basal cell carcinoma favours a concept of this tumour as a more primitive follicular lesion with the characteristics of a carcinoma and not a hamartoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. Hair Follicle / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Receptor, Nerve Growth Factor / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Merkel Cells / metabolism. Middle Aged. Skin / embryology. Skin / metabolism

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  • (PMID = 20184585.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptor, Nerve Growth Factor
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54. Cortés-Charry R, Figueira LM, García-Barriola V, Gomez C, Garcia I, Santiago C: Gestational trophoblastic disease in ectopic pregnancy: A case series. J Reprod Med; 2006 Oct;51(10):760-3
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  • OBJECTIVE: To describe 6 cases of gestational trophoblastic disease (GTD) in ectopic pregnancy admitted to Hospital Universitario de Caracas (HUC).
  • Ultrasound revealed an adnexal tumor in 5 cases; this tumor and hemoperitoneum (6 cases) were the most frequent surgical findings.


55. Yazbek J, Raju SK, Ben-Nagi J, Holland TK, Hillaby K, Jurkovic D: Effect of quality of gynaecological ultrasonography on management of patients with suspected ovarian cancer: a randomised controlled trial. Lancet Oncol; 2008 Feb;9(2):124-31
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  • BACKGROUND: The diagnostic accuracy of ultrasonography for differentiating between benign and malignant adnexal masses is proportional to the expertise of the operator.
  • However, we do not know whether improved diagnostic accuracy will affect the management of these tumours.
  • METHODS: 165 patients who were referred to the regional gynaecological cancer centre at Guy's and St Thomas' NHS Foundation Trust (London, UK), between June 7, 2004, and April 23, 2006, with suspected adnexal tumours met the inclusion criteria.


56. Zhang Q, Wojno TH, Fitch SD, Grossniklaus HE: Mucinous eccrine adenocarcinoma of the eyelid: report of 6 cases. Can J Ophthalmol; 2010 Feb;45(1):76-8
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  • CONCLUSIONS: Mucinous eccrine adenocarcinoma is an uncommon adnexal tumour that can involve the eyelid, has low metastasis and mortality, but can be invasive or locally recur.

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  • (PMID = 20130716.001).
  • [ISSN] 1715-3360
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / P30 EY006360; None / None / / P30 EY006360-25; United States / NEI NIH HHS / EY / P30 EY006360-25
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS239412; NLM/ PMC2992875
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57. Roussel A, Thomassin-Naggara I, Darai E, Marsault C, Bazot M: [Value of diffusion-weighted imaging in the evaluation of adnexal tumors]. J Radiol; 2009 May;90(5 Pt 1):589-96
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  • [Title] [Value of diffusion-weighted imaging in the evaluation of adnexal tumors].
  • [Transliterated title] Evaluation de la séquence de diffusion pour l'étude des tumeurs annexielles.
  • PURPOSE: To determine the value of diffusion-weighted imaging (DWI) in the evaluation of adnexal tumors, especially to distinguish between malignant and benign tumors.
  • Fifty-four patients with pelvic tumors (32 malignant and 22 benign) were referred for MRI of the pelvis.
  • The signal of solid and cystic tumor components was evaluated on T2W and b=1000 DWI, and ADC values were obtained.
  • RESULTS: T2W hypointensity or absence of hyperintense signal on b=1000 DWI sequences was suggestive of a benign tumor.
  • ADC values did not appear to discriminate between malignant and benign tumors.
  • Also, the signal intensity of cystic tumor components on DWI sequences was not helpful to distinguish between malignant and benign tumor.
  • CONCLUSION: The evaluation of solid tumor components on DWI appears to be helpful for adnexal tumor characterization.
  • [MeSH-major] Adnexal Diseases / diagnosis. Diffusion Magnetic Resonance Imaging / methods. Genital Neoplasms, Female / diagnosis. Image Enhancement. Image Processing, Computer-Assisted
  • [MeSH-minor] Adnexa Uteri / pathology. Adnexa Uteri / surgery. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Middle Aged. Sensitivity and Specificity. Young Adult

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  • (PMID = 19503047.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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58. Jamalipour M, Heidarpour M, Rajabi P: Generalized eruptive syringomas. Indian J Dermatol; 2009;54(1):65-7
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  • Generalized eruptive syringoma is a rare clinical presentation of a benign adnexal tumor that derives from the intraepidermal portion of the eccrine sweat ducts.
  • Treatment of this benign condition is cosmetic only.
  • A case of a 28-year-old female with an eight-year history of eruptive syringoma is presented.

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  • (PMID = 20049275.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2800876
  • [Keywords] NOTNLM ; Generalized eruptive syringoma / eccrine ducts / papules
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59. Zaraa I, Zeglaoui F, Fazaa B, Ezzine N, Elfekih N, Zermani R, Ben Jilani S, Kamoun MR: [Brooke-Spiegler syndrome]. Tunis Med; 2006 Sep;84(9):578-80
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  • [Transliterated title] Syndrome de brooke-Spiegler.
  • Brooke Spiegler syndrome is a rare genodermatosis characterized by an association of multiple trichoepitheliomas and cylindromas, sometimes accompanied by other adnexal tumors (spiradenoma, mila), we report two family cases of Brooke Spiegler syndrome.
  • No neoplastic tumor was identified.
  • A co-existence of adnexal tumors was found in the other members of the family.
  • Brooke Spiegler syndrome is an autosomial dominant disease with variable penetrance, it's characterized by a family history of trichoepitheliomas, with other adnexal tumors.
  • Brooke Spiegler syndrome is usually a benign disease, but patients with this syndrome should be explored for malignancy.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics

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  • (PMID = 17263207.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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60. Blasini W, Hu S, Gugic D, Vincek V: Papillary eccrine adenoma in association with cutaneous horn. Am J Clin Dermatol; 2007;8(3):179-82
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  • [Title] Papillary eccrine adenoma in association with cutaneous horn.
  • Papillary eccrine adenoma (PEA) is an uncommon sweat gland neoplasm that occurs more frequently on the distal extremities of Black women.
  • Concurrent occurrence of PEA and HPV-like epidermal changes may be coincidental; however, their co-occurrence may also be related to the environment induced by this adnexal tumor.
  • [MeSH-major] Adenoma / complications. Keratosis / complications. Sweat Gland Neoplasms / complications

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  • (PMID = 17492846.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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61. Valentin L: Imaging in gynecology. Best Pract Res Clin Obstet Gynaecol; 2006 Dec;20(6):881-906
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  • This chapter summarizes the diagnostic performance (sensitivity, specificity, positive and negative likelihood ratios) of ultrasound, computer tomography, and magnetic resonance imaging in the diagnosis of various gynecological diseases and tumors.
  • Imaging in infertility, in the diagnosis of Mullerian duct anomalies and in gynecological oncology (staging of gynecological cancers, diagnosis of recurrence of gynecological cancer, diagnosis of trophoblastic tumors) is not dealt with.
  • Ultrasound is the first-line imaging method for discrimination between viable intrauterine pregnancy, miscarriage and tubal pregnancy in women with bleeding and/or pain in early pregnancy, for discrimination between benign and malignant adnexal masses and for making a specific diagnosis in adnexal tumors (e.g. dermoid cyst, endometrioma, hemorrhagic corpus luteum, etc.
  • [MeSH-minor] Abortion, Spontaneous / ultrasonography. Adnexal Diseases / ultrasonography. Female. Humans. Magnetic Resonance Imaging / methods. Pelvic Pain / ultrasonography. Pregnancy. Pregnancy Trimester, First. Pregnancy, Ectopic / ultrasonography. Sensitivity and Specificity. Tomography, X-Ray Computed / methods. Uterine Hemorrhage / ultrasonography. Uterine Neoplasms / diagnosis

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  • (PMID = 16904942.001).
  • [ISSN] 1521-6934
  • [Journal-full-title] Best practice & research. Clinical obstetrics & gynaecology
  • [ISO-abbreviation] Best Pract Res Clin Obstet Gynaecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 172
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62. Hong SK, Lee HJ, Cho SH, Seo JK, Lee D, Sung HS: Syringomas Treated by Intralesional Insulated Needles without Epidermal Damage. Ann Dermatol; 2010 Aug;22(3):367-9
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  • Syringoma is a benign adnexal tumor derived from intradermal eccrine ducts; it predominantly occurs in women at puberty or later in life.
  • Although syringoma is a common benign neoplasm, there have been no effective therapies for its removal.

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  • (PMID = 20711282.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917699
  • [Keywords] NOTNLM ; Insulated needle / Syringoma
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63. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
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  • [Title] Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case.
  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.
  • Although some adnexal neoplasms that develop in association with a nevus sebaceus may exhibit conjoint sebaceous, follicular, or apocrine differentiation, reflecting close embryological relations of the folliculosebaceous-apocrine unit, the feature we report on has not previously been described to the best of our knowledge.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


64. Cribier B: [Accurate diagnosis of adnexal tumours can be a matter of life or death]. Ann Dermatol Venereol; 2009 Feb;136(2):125-32
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  • [Title] [Accurate diagnosis of adnexal tumours can be a matter of life or death].
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology

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  • (PMID = 19232249.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 58
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65. Obaidat NA, Ghazarian DM: A proliferating composite adnexal tumour of the penis: report of the first case. J Clin Pathol; 2007 May;60(5):567-9
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  • [Title] A proliferating composite adnexal tumour of the penis: report of the first case.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / pathology. Penile Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17513517.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1994519
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66. Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R: Syringocystadenoma papilliferum: report of 8 cases. Pathologica; 2006 Jun;98(3):178-80
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  • Syringocystadenoma papilliferum (SCAP) is a rare cutaneous adnexal neoplasm with variable clinical appearance and characteristic histology.
  • It arises in about one third of cases within a sebaceous hamartoma (SH) and in this case, multiple other benign adnexal neoplasms may be associated with it.
  • Three tumors were localized in the scalp, 2 in the trunk, and 3 others of unusual locations: 1 in the eyelid, 1 in the thigh and 1 in the popliteal fossa.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17036946.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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67. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Title] Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CASE: A 60-year-old woman, diagnosed with rectal adenocarcinoma 6 months before, underwent fine needle aspiration (FNA) of a nodule on the scalp.
  • CONCLUSION: Rapid, accurate diagnosis of these tumors is important, particularly when they develop at sites where a metastatic process must be ruled out.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. He XL, Wang CN, Zhang JM: [Clear cell papillary cystadenoma of left mesosalpinx associated with von Hippel-Lindau disease: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2009 May;38(5):349-50
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  • [Title] [Clear cell papillary cystadenoma of left mesosalpinx associated with von Hippel-Lindau disease: report of a case].
  • [MeSH-minor] Adenoma / pathology. Adnexal Diseases / pathology. Adult. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / secondary. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Keratin-7 / metabolism. Kidney Neoplasms / pathology. Kidney Neoplasms / secondary. Mucin-1 / metabolism

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  • (PMID = 19575884.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Keratin-7; 0 / Mucin-1; Wolffian tumor
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69. Takeda A, Sakai K, Mitsui T, Nakamura H: Management of large cystic adnexal tumor by gasless laparoscopic-assisted surgery with wound retractor. J Minim Invasive Gynecol; 2007 Sep-Oct;14(5):644-50
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  • [Title] Management of large cystic adnexal tumor by gasless laparoscopic-assisted surgery with wound retractor.
  • We used a retrospective analysis to evaluate the efficacy of a wound retractor used in gasless laparoscopic-assisted surgery by the subcutaneous abdominal wall-lift method for the management of large cystic adnexal tumors.
  • In the department of gynecology at a general hospital, 39 patients with large cystic adnexal tumors with an excised tissue weight including cystic contents exceeding 1000 g were treated by gasless laparoscopic-assisted surgery with a wound retractor from January 2001 through December 2006.
  • Intervention was with a gasless laparoscopic-assisted adnexal surgery with a wound retractor.
  • Histopathologic diagnosis of the excised tumor was mucinous cystadenoma, 18 cases; serous cystadenoma, 8 cases; mucinous cystadenocarcinoma of low-grade malignancy, 5 cases; dermoid cyst, 4 cases; paraovarian cyst, 2 cases; endometriotic cyst, 1 case; and clear cell adenocarcinoma, 1 case.
  • Bilateral adnexal tumors were noted in 3 cases.
  • We determined that gasless laparoscopic-assisted adnexal surgery with a wound retractor is an effective, minimally invasive procedure to treat large cystic adnexal tumors.

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  • (PMID = 17848329.001).
  • [ISSN] 1553-4650
  • [Journal-full-title] Journal of minimally invasive gynecology
  • [ISO-abbreviation] J Minim Invasive Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Cabo H, Pedrini F, Cohen Sabban E: Dermoscopy of cylindroma. Dermatol Res Pract; 2010;2010
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  • Background. Dermoscopy provides additional criteria for the diagnosis of nonpigmented skin lesions. Case Report.
  • Conclusion. Our case suggests that cylindromas may be added to the list of adnexal tumors mimicking BCC.

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  • (PMID = 20862372.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2938454
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71. Zaballos P, Llambrich A, Ara M, Olazarán Z, Malvehy J, Puig S: Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patients. Br J Dermatol; 2006 Feb;154(2):244-50
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  • However, the differentiation of dermatofibroma from other cutaneous tumours is difficult in some instances, primarily in atypical cases and rare variants.
  • The clinical differential diagnosis of haemosiderotic or aneurysmal dermatofibroma must include melanoma and other melanocytic tumours, vascular neoplasms, adnexal tumours and nonspecific cysts.
  • Dermoscopy improves the diagnostic accuracy in pigmented and nonpigmented skin lesions.
  • [MeSH-major] Dermoscopy. Hemosiderin / analysis. Histiocytoma, Benign Fibrous / diagnosis. Skin Neoplasms / diagnosis

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  • [CommentIn] Br J Dermatol. 2007 Jan;156(1):199-200 [17199605.001]
  • (PMID = 16433792.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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72. Monteagudo B, Antón-Badiola IM, Muñoz MJ, Paredes-Suárez C, Vázquez-Blanco M: [Pigmented apocrine hidradenoma]. Actas Dermosifiliogr; 2005 Jan-Feb;96(1):50-1
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  • Apocrine hidradenoma is a benign adnexal neoplasm.
  • The same as other tumors of the sweat glands, there is a pigmented variety.
  • We present the case of a 92-year-old male who consulted his physician for a slow-growing asymptomatic lesion in the right groin which had been developing for 2 years.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Hyperpigmentation / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476334.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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73. Grey BR, Verma S, Maddineni SB, Lau MW, Clarke NW: Male adnexal tumour of wolffian origin: the first report of metastatic disease. Scand J Urol Nephrol; 2009;43(3):253-6
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  • [Title] Male adnexal tumour of wolffian origin: the first report of metastatic disease.
  • The first case of a male adnexal tumour of probable wolffian duct origin to develop metastatic disease is reported.
  • The characteristic histological appearance and immunohistochemical profiles of the primary and metastatic male tumours are discussed.

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  • (PMID = 18985546.001).
  • [ISSN] 0036-5599
  • [Journal-full-title] Scandinavian journal of urology and nephrology
  • [ISO-abbreviation] Scand. J. Urol. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
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74. Schadt CR, Boyd AS: Eccrine syringofibroadenoma with co-existent squamous cell carcinoma. J Cutan Pathol; 2007 Dec;34 Suppl 1:71-4
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  • Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals.
  • Histologically, the tumor consists of anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Squamous Cell / pathology. Eccrine Glands / pathology. Fibroadenoma / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17997744.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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75. Marret H, Wagner N, Ouldamer L, Jacquet A, Body G: [Pelvic actinomycosis: just think of it]. Gynecol Obstet Fertil; 2010 May;38(5):307-12
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  • OBJECTIVES: Pelvic actinomycosis is a rare disease that can be diagnosed before, during or after surgical treatment of a suspected ovarian tumor, a suspected bowel obstruction, or acute peritonitis.
  • If there is no fever in association with an atypical adnexal tumor, frozen section should be obtained during surgery to rule out the diagnosis of actinomycosis.

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20430667.001).
  • [ISSN] 1769-6682
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Penicillins
  • [Number-of-references] 36
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76. Sicilia V, Earle J, Mezitis SG: Multiple ovarian cysts and oligomenorrhea as the initial manifestations of a gonadotropin-secreting pituitary macroadenoma. Endocr Pract; 2006 Jul-Aug;12(4):417-21
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  • [Title] Multiple ovarian cysts and oligomenorrhea as the initial manifestations of a gonadotropin-secreting pituitary macroadenoma.
  • OBJECTIVE: To report a case of a follicle-stimulating hormone (FSH)-secreting pituitary adenoma, which manifested with oligomenorrhea, dysmenorrhea, and multiple bilateral ovarian cysts.
  • METHODS: We present a case report of a 29-year-old woman, including detailed laboratory, radiologic, and pathologic findings, who was diagnosed as having an FSH-secreting pituitary tumor.
  • Ultrasonography revealed multicystic ovaries >15 cm in maximal diameter, causing bilateral adnexal torsion.
  • Transsphenoidal removal of the mass was performed, and pathology studies were positive for FSH-secreting adenoma.
  • Repeated MRI at 3 months showed an 0.8-cm residual tumor.
  • Almost 3 years after treatment, the patient remained asymptomatic, results of pituitary function tests were normal, and follow-up MRI showed no signs of tumor regrowth.
  • Furthermore, we propose that it may be acceptable to withhold adjuvant radiotherapy in patients who are asymptomatic after transsphenoidal surgical excision of these tumors.
  • [MeSH-minor] Adenoma / complications. Adult. Female. Follicle Stimulating Hormone / secretion. Humans. Immunohistochemistry. Luteinizing Hormone / secretion

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  • (PMID = 16901798.001).
  • [ISSN] 1530-891X
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadotropins; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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77. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Title] Spiradenocylindrocarcinoma: a malignant hybrid tumor.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • Benign tumors demonstrating both spiradenomatous and cylindromatous features have been infrequently reported.
  • Recent immunohistochemical studies of these two tumors have provided compelling evidence that these two tumors may merely represent a single tumor type with a spectrum of histological features.
  • CASE REPORT: We describe two cases of a malignant variant of this rare hybrid tumor occurring in a 62-year-old male and a 72-year-old female.
  • CONCLUSION: We propose the term 'spiradenocylindrocarcinoma' to describe malignant tumors with features of both a spiradenoma and a cylindroma.
  • In conjunction with histological features of malignancy, p53 and Ki-67 immunohistochemical staining may provide helpful clues in determining the malignant potential of this tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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78. De Francesco V, Frattasio A, Pillon B, Stinco G, Scott CA, Trotter D, Patrone P: Carcinosarcoma arising in a patient with multiple cylindromas. Am J Dermatopathol; 2005 Feb;27(1):21-6
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  • Familial cylindromatosis (Brooke-Spiegler syndrome) is a rare autosomal dominant inherited disease characterized by the development of adnexal tumors, mostly cylindromas, but also trichoepitheliomas and spiradenomas.
  • Malignant tumors may occur, usually with the features of a cylindrocarcinoma.
  • The authors describe the case of a 75-year-old woman with the Brooke-Spiegler syndrome who presented with multiple nodules of the scalp, face, and trunk.
  • In 1997 she underwent surgical excision of the entire forehead and scalp with skin grafting.
  • The lesion was excised and histologic and immunohistochemical evaluation revealed a malignant cutaneous biphasic tumor extending into the subcutis, consisting of a major portion with the features of an adnexal carcinoma and of a minor one of atypical spindle cells.
  • Biphasic malignant skin tumors are rare and only a limited number have been described, none in association with the Brooke-Spiegler syndrome.
  • The authors discuss the morphogenesis of the folliculosebaceous-apocrine unit from which the tumors in this syndrome derive, and the pivotal role of mesenchymal cells in determining the process.
  • Since the Brooke-Spiegler syndrome is characterized by a germline mutation in the CYLD oncosuppressor gene, a biphasic tumor in this setting may represent a true carcinosarcoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Skin Appendage / pathology. Carcinosarcoma / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Skin Transplantation. Treatment Outcome

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  • (PMID = 15677972.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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79. Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC Jr, Hoang MP: Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol; 2009 Apr;22(4):600-10
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  • We compare the histological features and Ki-67, phosphorylated histone H3, epidermal growth factor receptor, and Her2/neu expression profiles of 15 atypical and 15 malignant hidradenomas with those of benign hidradenoma and metastasizing adnexal carcinomas.
  • Significant difference in mean Ki-67% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.002), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (0.002).
  • Significant difference in mean phosphorylated histone H3% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.003), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (P<0.001).
  • Mean epidermal growth factor receptor total score was significantly different in benign and atypical hidradenoma when compared with that in metastasizing adnexal carcinoma (P=0.014 and 0.019, respectively).
  • Equivocal or 2+ Her2/neu positivity was observed in one hidradenocarcinoma and in two metastasizing adnexal carcinomas.
  • A tumor with Ki-67>11% and/or phosphorylated histone H3>0.7% would likely be a malignant rather than an atypical hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Biomarkers, Tumor / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 19252473.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Histones; 0 / Ki-67 Antigen; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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80. de Silva DJ, Tay E, Rose GE: Schwannomas of the lacrimal gland fossa. Orbit; 2009;28(6):433-5
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  • PURPOSE: Schwannomas are rare benign nerve sheath tumours that account for 1% of orbital tumours and, although sometimes associated with neurofibromatosis, most occur as isolated lesions and arise from branches of the ciliary or trigeminal nerves.
  • METHODS: Two rare cases of Schwannoma arising within the lacrimal gland fossa are presented, these tumours being managed with intact surgical excision.
  • On a presumptive preoperative diagnosis of pleomorphic adenoma, the patient underwent a bone-swinging lateral orbitotomy with intact excision of a moderately-firm, lobulated lesion which proved to be a Schwannoma.
  • Although lacrimal gland remnants were present at the edge of both specimens, at surgery it was evident that the tumours completely occupied the lacrimal gland fossa and any normal orbital lobe of the lacrimal gland had undergone atrophy.
  • CONCLUSIONS: Two very rare cases of Schwannoma arising within the lacrimal gland fossa are presented, the tumours causing complete atrophy of the normal orbital lobe of the lacrimal gland.
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Glial Fibrillary Acidic Protein / analysis. Humans. S100 Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 19929679.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
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81. Vavilis D, Athanatos D, Tsolakidis D, Papanicolaou A, Bontis JN: Mucocele of the appendix mimicking an adnexal mass: a case report. Clin Exp Obstet Gynecol; 2009;36(2):135-6
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  • [Title] Mucocele of the appendix mimicking an adnexal mass: a case report.
  • Mucocele of the appendix is a rare entity usually mimicking an adnexal tumour.
  • We present a case of an appendiceal mucocele mimicking an ovarian tumour by both clinical and imaging (TVS and MRI) methods.
  • This pathological condition should be considered by all the gynaecologists in the differential diagnosis of a right-sided pelvic mass.
  • [MeSH-major] Adnexal Diseases / diagnosis. Appendiceal Neoplasms / diagnosis. Cystadenoma, Mucinous / diagnosis. Mucocele / diagnosis

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  • (PMID = 19688962.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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82. Seirafi HH, Akhyani M, Naraghi ZS, Mansoori P, Dehkordi HS, Taheri A, Ehsani AH, Kavusi S, Farnaghi F: Eruptive syringomas. Dermatol Online J; 2005;11(2):13
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  • Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts.

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  • (PMID = 16150221.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Zimmer M, Pomorski M, Wiatrowski A, Fuchs T, Myszczyszyn G: Application of endoscopy in pediatric and adolescent gynecology. Neuro Endocrinol Lett; 2008 Feb;29(1):11-5
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  • The laparoscopy is becoming a more and more popular method in the treatment of adnexal tumors in children, due to its little invasiveness, quick recovery and less severe pain complaints after the surgery.
  • They should be considered diagnostics and treatment of choice in the pathology of vulva, vagina, developmental anomalies of sex organ and adnexal tumors in patients of the developmental age.

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  • (PMID = 18283270.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Sweden
  • [Number-of-references] 23
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84. Chia CC, Huang SC: A feasible laparoscopic surgery technique for complex adnexal tumors. Taiwan J Obstet Gynecol; 2007 Mar;46(1):83-4
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  • [Title] A feasible laparoscopic surgery technique for complex adnexal tumors.
  • [MeSH-major] Adnexal Diseases / surgery. Cysts / surgery. Genital Neoplasms, Female / surgery. Laparoscopy / methods

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  • [CommentIn] Taiwan J Obstet Gynecol. 2007 Jun;46(2):185-6; author reply 186 [17638632.001]
  • (PMID = 17389199.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] China
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85. Plaza JA, Ortega PF, Bengana C, Stockman DL, Suster S: Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases. Am J Dermatopathol; 2010 Oct;32(7):683-7
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  • When the morphologic distinction between basal cell carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two neoplasms from each other.
  • Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous neoplasms, such as adnexal tumors, squamous cell carcinomas, etc.
  • A total of 49 cutaneous tumors, including 22 cases of trichoepitheliomas and 27 cases of BCC were examined.
  • This data suggests that D2-40 expression could be a useful potential marker to distinguish BCCs from trichoepitheliomas, especially when there is a high index of histologic suspicion for either of these two tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Membrane Glycoproteins / biosynthesis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20559122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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86. Lee CY, Tseng CC, Wang CB, Lin YH, Chen CH, Wun TH, Sun YL, Tseng CJ: A new quantitative method to evaluate adnexal tumors. Taiwan J Obstet Gynecol; 2010 Mar;49(1):45-9
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  • [Title] A new quantitative method to evaluate adnexal tumors.
  • We chose quantitative tumor density and standard deviation on sonographic images as the new diagnostic parameters.
  • Analysis of variance and Scheffé post hoc test were analyzed to compare the mean tumor density of the endometriomas and follicular cysts.
  • The receiver operating characteristic curve was plotted to choose the cutoff value of the endometrioma tumor density with the best sensitivity and specificity.
  • RESULTS: There was a significant difference when the tumor density of the follicular cyst and endometrioma groups was compared using the vaginal, abdominal or endovaginal approach (p < 0.001).
  • With endovaginal ultrasonography examination, the best cutoff value of tumor density is 28 and the sensitivity and specificity are 64% and 100%, respectively.
  • CONCLUSION: The use of quantitative tumor density and standard deviation on sonographic images is a potential new diagnostic tool in the assessment of endometriomas and follicular cysts.
  • [MeSH-major] Adnexal Diseases / diagnosis. Endometriosis / diagnosis. Follicular Cyst / diagnosis. Ultrasonography / methods

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  • (PMID = 20466292.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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87. Sariya D, Ruth K, Adams-McDonnell R, Cusack C, Xu X, Elenitsas R, Seykora J, Pasha T, Zhang P, Baldassano M, Lessin SR, Wu H: Clinicopathologic correlation of cutaneous metastases: experience from a cancer center. Arch Dermatol; 2007 May;143(5):613-20
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  • OBJECTIVE: To analyze the clinical, histopathologic, and immunohistochemical characteristics of skin metastases.
  • PATIENTS: Fifty-one patients (21 men and 30 women) with biopsy-proven skin metastases and correlative clinical data.
  • INTERVENTIONS: Four dermatopathologists reviewed a random mixture of metastases and primary skin tumors.
  • Immunohistochemical studies for 12 markers were performed on the metastases, with skin adnexal tumors as controls.
  • RESULTS: Eighty-six percent (43 of 50) of the patients had known stage IV cancer, and skin metastasis was the presenting sign in 12% (6 of 50).
  • Metastases from small cell carcinomas and sarcomas were histologically misinterpreted as primary skin tumors.
  • Immunohistochemical analysis using a panel including p63, B72.3, calretinin, and CK5/6 differentiated metastatic carcinoma from primary skin adnexal tumors.
  • CONCLUSIONS: Cutaneous metastases can have variable clinical appearances and can mimic benign skin lesions.
  • [MeSH-major] Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cancer Care Facilities. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 17515511.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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88. Bhadani PP, Sen R, Bhadani UK, Karki S, Agarwal S: Is fine needle aspiration cytology (FNAC) useful in skin adnexal masses? A study on 5 cases of pilomatixoma. Indian J Pathol Microbiol; 2007 Apr;50(2):411-4
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  • [Title] Is fine needle aspiration cytology (FNAC) useful in skin adnexal masses? A study on 5 cases of pilomatixoma.
  • Superficial cutaneous/subcutaneous nodules, caused by a variety of inflammatory, benign and malignant pathology of diverse origin, are tempting lesion for fine needle aspiration cytology (FNAC).
  • Amongst these, adnexal tumor show considerable overlap, both in clinical manifestation as well as in histopathology.
  • Other cases were diagnosed as epidermal inclusion cyst with the differential diagnosis of well differentiated squamous cell carcinoma and skin appendageal tumor of undetermined origin in one case each.
  • [MeSH-major] Hair Diseases / diagnosis. Pilomatrixoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17883095.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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89. Emsen IM, Livaoglu A: An uncommon folliculosebaceous cystic hamartoma on the lower extremity. Can J Plast Surg; 2007;15(4):231-3
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  • Clinical differential diagnoses included nevus, neurofibroma and adnexal tumour.

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  • [Cites] J Dermatol. 1993 Nov;20(11):712-4 [8300942.001]
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  • (PMID = 19554184.001).
  • [ISSN] 1195-2199
  • [Journal-full-title] The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
  • [ISO-abbreviation] Can J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2696010
  • [Keywords] NOTNLM ; Exophytic papules / Folliculosebaceous cystic hamartoma / Hamartoma / Immunohistological features / Nodules / Sebaceous glands
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90. Kondoh A, Akasaka E, Yamamoto K, Mizutani K, Iwashita K, Umezawa Y, Ohta Y, Matsuyama T, Ozawa A: A case of implantation dermatosis that formed a tumor. J Dermatol; 2006 Feb;33(2):122-7
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  • [Title] A case of implantation dermatosis that formed a tumor.
  • A 51-year-old man visited our hospital complaining of a tumor located above his lip.
  • The lesion turned into a tumor and gradually enlarged.
  • The tumor was well circumscribed, smooth and covered with reddish, partially milk-white skin.
  • During surgery to remove the tumor, a piece of a chopstick was found in the subcutaneous tissue, and a diagnosis of implantation dermatosis (ID) was made.
  • On histology, the tumor appeared as an abscess that had increased fibroblasts, small vessels and a large number of neutrophils.
  • In the Japanese published work, we found 86 cases of ID; three were similar to our case and had been clinically diagnosed as adnexal tumors.
  • [MeSH-major] Foreign Bodies / complications. Foreign-Body Reaction / etiology. Foreign-Body Reaction / pathology. Skin. Skin Diseases / etiology

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  • (PMID = 16556281.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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91. Hyun DN, Won JH, Park JS, Chung H: A Case of Steatocystoma Simplex Involving the Scalp. Ann Dermatol; 2008 Dec;20(4):230-2
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  • Steatocystoma is a benign adnexal tumor originating from the pilosebaceous duct junction which can be classified into two groups (steatocystoma simplex and steatocystoma multiplex).
  • A 49-year-old man presented for evaluation and treatment of a solitary papule on the right parietal scalp which had persisted for a period of 1 year.

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  • (PMID = 27303199.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4903986
  • [Keywords] NOTNLM ; Scalp / Steatocystoma simplex
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92. Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R: Squamoid eccrine ductal carcinoma: a case report and review of the literature. Am J Dermatopathol; 2010 May;32(3):287-92
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  • Eccrine ductal carcinoma is a rare adnexal tumor.
  • This neoplasm is deeply infiltrative and may provide a diagnostic challenge in superficial shave biopsies of skin.
  • We present a case of SEDC in an immunocompromised patient, who, after an initial shave biopsy for diagnostic purposes, underwent a complete excision of his tumor by Mohs micrographic surgery.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Immunocompromised Host. Male. Middle Aged. Mohs Surgery

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  • (PMID = 20010402.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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93. Katona TM, Billings SD, Montironi R, Lopez-Beltran A, Cheng L: Expression of OCT4 transcription factor in cutaneous neoplasia. Appl Immunohistochem Mol Morphol; 2007 Dec;15(4):359-62
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  • We have examined a series of basal cell carcinomas and adnexal tumors of related histogenesis, in an effort to corroborate the above findings and to assess for expression of OCT4 protein in neoplasia of the infundibulo-apocrine-sebaceous unit.
  • We analyzed OCT4 expression in 115 cutaneous specimens including 26 basal cell carcinomas, 12 benign follicular tumors (10 trichoepitheliomas and 2 trichoblastomas), 10 benign apocrine tumors, 12 sebaceous hyperplasia lesions, 10 sebaceous adenomas, 4 sebaceous carcinomas, 13 nevi sebacei of Jadassohn, 8 squamous cell carcinomas (including one spindle-cell squamous cell carcinoma), 8 compound melanocytic nevi, 5 Merkel cell carcinomas, 3 pilar cysts, 1 scar, 2 nonspecific, mild superficial perivascular dermatitis specimens, and 1 non-scarring alopecia.
  • In contrast to previous studies, our data indicate that the OCT4 expression is not retained in cutaneous neoplasms derived from basal epidermis or related adnexal neoplasms, including lesions of the scalp.

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  • (PMID = 18091376.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human
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94. Kapetanakis V, Karlin NJ, McCullough AE, Magtibay PM: Primary ovarian malignant lymphoma presenting as ovarian carcinomatosis: a case report and literature review. Eur J Gynaecol Oncol; 2010;31(6):701-2
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  • CASE: We report a case of a 78-year-old woman who presented with an ovarian neoplasm suggestive of advanced ovarian carcinoma.
  • CONCLUSION: Primary ovarian lymphoma presenting as an ovarian tumor is exceedingly rare.
  • Since the prognosis and treatment of lymphoma differs significantly from ovarian carcinoma, a representative tissue sample of the adnexal tumor should be obtained and sent for frozen section analysis to establish the diagnosis.


95. Presutti L, Alicandri-Ciufelli M, Mattioli F, Marchioni D, Costantini M: A case of syryngocystadenoma papilliferum (SCAP) involving middle ear, presenting with otomastoiditis and cerebral abscess. Auris Nasus Larynx; 2008 Sep;35(3):401-3
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  • Syryngocystadenoma papilliferum (SCAP) is an uncommon cutaneous adnexal neoplasm of apocrine gland origin.
  • We describe a case of SCAP of external and middle ear, presenting with otomastoiditis and cerebral abscess; this aggressive behavior, never reported for a benign adenoma of the external or middle ear, could lead to a differential diagnosis with cholesteatoma or malignancies.

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  • (PMID = 17870265.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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96. Vidal VP, Ortonne N, Schedl A: SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. J Cutan Pathol; 2008 Apr;35(4):373-9
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  • [Title] SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms.
  • Here we test whether activation of SOX9 is a general feature of BCC, or whether it could be used as a biomarker to better define subtypes of these skin tumors.
  • In addition we investigated SOX9 expression in other skin epidermal tumors.
  • METHODS: Tumors sections were stained with hematoxylin & eosin (H&E).
  • Staining was heterogeneous and could be detected among the basaloid cells of the palisading cell layer as well as in the tumour nest.
  • SOX9 expression was detected in all adnexal tumors analyzed and absent in Bowen's disease and Merkel tumor.
  • CONCLUSIONS: SOX9 expression is a general feature of BCC and adnexal skin neoplasms, suggesting a contribution of SOX9 to the pathogenesis of these tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / metabolism. High Mobility Group Proteins / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / metabolism. Transcription Factors / metabolism

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  • (PMID = 18333897.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / High Mobility Group Proteins; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / Transcription Factors
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97. Van Holsbeke C, Van Calster B, Testa AC, Domali E, Lu C, Van Huffel S, Valentin L, Timmerman D: Prospective internal validation of mathematical models to predict malignancy in adnexal masses: results from the international ovarian tumor analysis study. Clin Cancer Res; 2009 Jan 15;15(2):684-91
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  • [Title] Prospective internal validation of mathematical models to predict malignancy in adnexal masses: results from the international ovarian tumor analysis study.
  • PURPOSE: To prospectively test the mathematical models for calculation of the risk of malignancy in adnexal masses that were developed on the International Ovarian Tumor Analysis (IOTA) phase 1 data set on a new data set and to compare their performance with that of pattern recognition, our standard method.
  • CONCLUSION: This internal validation of mathematical models to estimate the malignancy risk in adnexal tumors shows that the IOTA models had a diagnostic performance similar to that in the original data set.
  • [MeSH-major] Adnexal Diseases / diagnosis. Adnexal Diseases / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology

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  • (PMID = 19147775.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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98. Moonda A, Fatteh S: Metastatic colorectal carcinoma: an unusual presentation. J Cutan Pathol; 2009 Jan;36(1):64-6
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  • They most commonly appear on the abdominal wall or perineal area; metastases to other locations of the skin are rare.
  • However, this entity should be considered in the differential diagnosis of adnexal tumors as it may be the initial presentation of the colon carcinoma.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Colorectal Neoplasms / pathology. Lip Neoplasms / secondary. Skin Neoplasms / secondary

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  • (PMID = 18715256.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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99. Schaller J, Rytina E, Rütten A, Hendricks C, Ha T, Requena L: Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases. J Cutan Pathol; 2010 Sep;37(9):1002-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases.
  • Microcystic adnexal carcinoma (MAC) is a rare, usually solitary, slowly growing, yet aggressive neoplasm with a tendency for local recurrences.
  • However, to our knowledge, the presence of a MAC-like ductal proliferation embedded in sclerotic stroma and extending to the deep dermis has not been previously described.
  • [MeSH-major] Adenoma / diagnosis. Facial Dermatoses / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / diagnosis. Skin / pathology. Sweat Glands / pathology

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  • (PMID = 20175822.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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100. Plaza JA, Ortega PF, Stockman DL, Suster S: Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases. J Cutan Pathol; 2010 Apr;37(4):403-10
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  • [Title] Value of p63 and podoplanin (D2-40) immunoreactivity in the distinction between primary cutaneous tumors and adenocarcinomas metastatic to the skin: a clinicopathologic and immunohistochemical study of 79 cases.
  • The distinction of metastatic carcinomas to the skin from poorly differentiated primary cutaneous carcinomas and sometimes primary benign adnexal tumors can pose a significant diagnostic challenge.
  • The purpose of this study was to evaluate the role of p63 and podoplanin (D2-40) immunoreactivity for separating primary skin tumors vs. cutaneous metastases of carcinomas from internal organs.
  • Thirty seven primary tumors and 42 cutaneous metastatic adenocarcinomas were evaluated.
  • The 37 primary cutaneous tumors included 14 cases of benign adnexal tumors, 9 malignant skin adnexal neoplasms, and 14 primary squamous and basal cell carcinomas.
  • The 42 metastatic adenocarcinomas all corresponded to metastases from patients with a well-documented history of a primary tumor at another location.
  • We found variable positivity with podoplanin in all primary cutaneous neoplasms including spiradenoma (6/6), hidradenoma (2/4), cylindroma (3/3), desmoplastic trichilemmoma (1/1), poorly differentiated squamous cell carcinoma (4/4), sebaceous carcinoma (1/1), basal cell carcinoma (4/10), trichilemmal carcinoma (2/2), eccrine carcinoma (3/3), microcystic adnexal carcinoma (1/1), adnexal carcinoma NOS (1/1), and porocarcinoma (1/1).
  • In regards to p63, all cases of primary cutaneous tumors were positive for p63 (37/37); in contrast, all cutaneous metastatic carcinomas were negative (0/42).
  • Sensitivity, specificity, and positive and negative predictive values of podoplanin and p63 immunoreactivity to separate primary skin neoplasms from metastatic carcinomas were 78.4, 100.0, 100.0 and 84.0% for podoplanin, respectively, and 100.0, 100.0, 100.0 and 100.0% for p63, respectively.
  • The differences in p63 and podoplanin immunohistochemical expression between primary skin tumors and metastatic carcinomas to the skin were statistically significant (p < 0, 0001).
  • The results of our study suggest that the combined expression of p63 and podoplanin are a useful adjunct for the diagnosis of skin tumors in the clinical setting of a questionable metastasis and may be relatively specific for distinguishing primary skin tumors from metastatic carcinomas to the skin.
  • [MeSH-major] Adenocarcinoma / metabolism. Membrane Glycoproteins / metabolism. Membrane Proteins / metabolism. Skin / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 20377670.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / PDPN protein, human
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