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1. Sakai T, Iida S, Kishino M, Okura M, Kogo M: Sialolipoma of the hard palate. J Oral Pathol Med; 2006 Jul;35(6):376-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 60-year-old Japanese woman was referred to our department complaining of a painless swelling on the right side of the hard palate.
  • Intra-oral examination revealed a soft, elastic, dome-shaped mass with 1 cm in diameter located in the posterior part of the hard palate.
  • Incisional biopsy revealed that the tumor was encapsulated by fibrous tissue, consisted of adipose tissue, and also contained normal salivary gland tissue peripherally.
  • First diagnosed as an ordinary lipoma of the hard palate, the tumor was excised.
  • According to the recent criteria of histologic findings of sialolipoma, we rediagnosed the tumor as sialolipoma of the hard palate.
  • [MeSH-major] Lipoma / pathology. Palatal Neoplasms / pathology. Palate, Hard / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16762019.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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2. Kushida Y, Haba R, Kobayashi S, Ishikawa M, Doi T, Kadota K: Ectopic hamartomatous thymoma: a case report with immunohistochemical study and review of the literature. J Cutan Pathol; 2006 May;33(5):369-72
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  • Ectopic hamartomatous thymoma (EHT) is a rare benign tumor.
  • The tumor consisted of spindle cells, epithelial cells, adipose cells, and a small amount of lymphocytes, as described previously.
  • Recognition of EHT is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor.
  • [MeSH-major] Choristoma / pathology. Hamartoma / pathology. Soft Tissue Neoplasms / pathology. Thymoma. Thymus Neoplasms
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD1 / metabolism. Antigens, CD20 / metabolism. Antigens, CD34 / metabolism. Antigens, CD45 / metabolism. Cell Adhesion Molecules / metabolism. Diagnosis, Differential. Humans. Keratins / metabolism. Male. Nerve Sheath Neoplasms / pathology. Sarcoma, Synovial / metabolism. Sarcoma, Synovial / pathology. Vimentin / metabolism

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  • (PMID = 16640545.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD1; 0 / Antigens, CD20; 0 / Antigens, CD34; 0 / CD1a antigen; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin; 68238-35-7 / Keratins; EC 3.1.3.48 / Antigens, CD45
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3. Spyridopoulos TN, Petridou ET, Dessypris N, Terzidis A, Skalkidou A, Deliveliotis C, Chrousos GP, Obesity and Cancer Oncology Group: Inverse association of leptin levels with renal cell carcinoma: results from a case-control study. Hormones (Athens); 2009 Jan-Mar;8(1):39-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Leptin is primarily produced in adipose tissue and appears to play a modulatory role between metabolism and immunity.
  • [MeSH-major] Carcinoma, Renal Cell / blood. Kidney Neoplasms / blood. Leptin / blood

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  • (PMID = 19278051.001).
  • [ISSN] 1109-3099
  • [Journal-full-title] Hormones (Athens, Greece)
  • [ISO-abbreviation] Hormones (Athens)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Leptin
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4. Quaia E, Bussani R, Cova M, Mucelli RP: Radiologic-pathologic correlations of intratumoral tissue components in the most common solid and cystic renal tumors. Pictorial review. Eur Radiol; 2005 Aug;15(8):1734-44
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  • [Title] Radiologic-pathologic correlations of intratumoral tissue components in the most common solid and cystic renal tumors. Pictorial review.
  • This paper describes the correlation between US-CT images and pathologic findings in the most common solid and cystic renal tumors, to better differentiate malignant and benign renal masses.
  • Several intratumoral tissue components present correlation with US-CT images.
  • (3) hemorrhagic], calcific, and adipose.
  • [MeSH-major] Cysts / pathology. Kidney Diseases / pathology. Kidney Neoplasms / pathology

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  • (PMID = 15754162.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 36
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5. Menendez JA, Vellon L, Lupu R: Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells. Med Hypotheses; 2005;64(5):997-1001
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.
  • Trastuzumab (Herceptin) is a humanized antibody directed against the extracellular domain of the tyrosine kinase orphan receptor Her-2/neu (erbB-2) that has shown therapeutic efficacy against Her-2/neu-overexpressing breast tumors.
  • However, less than 35% of patients with Her-2/neu-overexpressing metastatic breast cancer respond to trastuzumab as a single agent, whereas the remaining cases do not demonstrate tumor regression.
  • Recent studies in breast cancer cells have revealed a bi-directional connection between Her-2/neu and fatty acid synthase (FAS), a major lipogenic enzyme catalyzing the synthesis of long-chain saturated fatty acids from the 2-carbon donors malonyl-CoA and acetyl-CoA.
  • Her-2/neu overexpression stimulates the FAS promoter and ultimately mediates increased endogenous fatty synthesis, and this Her-2/neu-mediated induction of breast cancer-associated FAS is inhibitable by trastuzumab.
  • Strikingly, FAS inhibition synergistically interacts with trastuzumab in Her-2/neu-negative breast cancer cells engineered to overexpress Her-2/neu, thus suggesting that the molecular linkage between FAS activity and functioning of Her-2/neu cannot be explained only on the basis of a transcriptional repression of Her-2/neu gene promoter.
  • Interestingly, while in liver and adipose tissue FAS produces fat from excess carbon consumed as carbohydrates, which is ultimately stored as triglycerides, in epithelial cancer cells, FAS activity is mainly involved in the production of phospholipids partitioning into detergent-resistant membrane microdomains (lipid raft-aggregates), which point to an active role of FAS in the deregulation of membrane functioning in tumor cells.
  • In summary, the specific blockade of a novel molecular linkage between FAS-regulated membrane composition and functioning of transmembrane growth factor receptors EGFR and Her-2/neu may represent a previously unrecognized therapeutic approach circumventing trastuzumab resistance in breast carcinomas.
  • [MeSH-major] Antibodies, Monoclonal / pharmacology. Antineoplastic Agents / therapeutic use. Breast Neoplasms / drug therapy. Drug Resistance, Neoplasm. Fatty Acid Synthases / metabolism. Lipid Metabolism


6. Voesten HG, Damstra RJ, Klinkert P: [New surgical options for patients with secondary lymphedema of the arm who no longer benefit from regular treatment]. Ned Tijdschr Geneeskd; 2008 May 3;152(18):1061-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Nieuwe chirurgische mogelijkheden voor patiënten met uitbehandeld secundair lymfoedeem van de arm.
  • The patients underwent reductive surgery by means of circumferential suction assisted lipectomy, involving removal of hypertrophied adipose tissue.
  • [MeSH-major] Adipose Tissue / surgery. Lipectomy. Lymphedema / surgery. Mastectomy / adverse effects
  • [MeSH-minor] Arm / pathology. Arm / surgery. Breast Neoplasms / surgery. Female. Humans. Middle Aged. Postoperative Complications / surgery

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  • (PMID = 18547030.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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7. Iannetti G, Rinna C, Saltarel A, Pagnoni M, Reale G: Hemangiopericytoma of the temporal muscle: clinical report. J Craniofac Surg; 2006 Jan;17(1):172-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Hemangiopericytoma / pathology. Muscle Neoplasms / pathology. Temporal Muscle / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Biopsy, Fine-Needle. Connective Tissue / pathology. Diagnosis, Differential. Follow-Up Studies. Hemangioma / pathology. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 16432428.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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8. Yamaguchi Y, Takei H, Suemasu K, Kobayashi Y, Kurosumi M, Harada N, Hayashi S: Tumor-stromal interaction through the estrogen-signaling pathway in human breast cancer. Cancer Res; 2005 Jun 1;65(11):4653-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-stromal interaction through the estrogen-signaling pathway in human breast cancer.
  • In postmenopausal breast cancers, locally produced estrogen by adipose stromal cells causes the progression of tumor growth.
  • Although aromatase, a key enzyme of estrogen synthesis, is highly expressed in the adipose stromal cells, and aromatase inhibitors show greater efficacy in postmenopausal breast cancers, the mechanism of increasing aromatase activity in the stromal cells remains unclear.
  • To analyze the estrogen signals and to detect the estrogen receptor (ER)-activating ability of adipose stromal cells for individual human breast cancers, we developed a new reporter cell system.
  • E10 cells specifically express GFP when ER is activated by estrogen or by coculture with adipose stromal cells isolated from breast tumor tissues in the presence of testosterone, a substrate for aromatase.
  • Treatment of adipose stromal cells with dexamethasone, a stimulator of aromatase gene expression, resulted in an increase in the expression of GFP in E10 cells in the coculture.
  • Using this system, we characterized the adipose stromal cells of 67 human breast cancers and found that GFP expression levels vary among the cases, suggesting that the ability of adipose stromal cells to activate ERs is unique for individual breast cancers.
  • High induction levels of GFP were observed more frequently in postmenopausal cases than in premenopausal cases, whereas they did not significantly correlate with the ER expression status.
  • Aromatase gene expression levels in adipose stromal cells did not always correlate with their ability to induce GFP.
  • These results suggest that this system to detect total ER activation based on the interaction with adipose stromal cells is a useful tool for analyzing local estrogen signals and for tumor-stromal interactions.
  • [MeSH-major] Breast Neoplasms / pathology. Cell Communication / physiology. Estrogens / physiology. Receptors, Estrogen / physiology
  • [MeSH-minor] Adipose Tissue / pathology. Aromatase / biosynthesis. Aromatase / genetics. Aromatase / metabolism. Aromatase Inhibitors / pharmacology. Cell Line, Tumor. Coculture Techniques. Gene Expression. Green Fluorescent Proteins / biosynthesis. Green Fluorescent Proteins / genetics. Humans. Signal Transduction / physiology. Stromal Cells / pathology. Transfection

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  • (PMID = 15930283.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / Estrogens; 0 / Receptors, Estrogen; 147336-22-9 / Green Fluorescent Proteins; EC 1.14.14.1 / Aromatase
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9. Accioly MT, Pacheco P, Maya-Monteiro CM, Carrossini N, Robbs BK, Oliveira SS, Kaufmann C, Morgado-Diaz JA, Bozza PT, Viola JP: Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Cancer Res; 2008 Mar 15;68(6):1732-40
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  • Increased lipid body numbers have been described in tumor cells; however, its functional significance in cancer has never been addressed.
  • Here, we showed increased number of lipid bodies in tumor tissues from patients with adenocarcinoma of colon submitted to surgical resection when compared with an adjacent normal tissue.
  • We showed by immunolocalization that, in addition to perinuclear stain, COX-2 and prostaglandin E (PGE) synthase present punctate cytoplasmic localizations that were concordant with adipose differentiation-related protein-labeled lipid bodies.
  • Treatment with either aspirin or the fatty acid synthase inhibitor C75 significantly reduced the number of lipid bodies and PGE(2) production in CACO-2 and in IEC-6 H-rasV12 cells with effects in cell proliferation.
  • [MeSH-major] Adenocarcinoma / metabolism. Colonic Neoplasms / metabolism. Cyclooxygenase 2 / metabolism. Dinoprostone / biosynthesis. Lipid Metabolism. Organelles / metabolism

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  • (PMID = 18339853.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 4-methylene-2-octyl-5-oxofuran-3-carboxylic acid; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone; OL659KIY4X / 4-Butyrolactone; R16CO5Y76E / Aspirin
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10. Ruiz E, Pozo P, Toselli L, Fernández M, Christiansen S, Lambertini R: Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma. Urology; 2008 Jun;71(6):1067-9
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  • [Title] Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma.
  • Paratesticular tumors are extremely rare, with paratesticular rhabdomyosarcoma being the most common finding.
  • A 6-month-old boy presented with an asymptomatic, right intrascrotal mass whereby the testicle was surrounded by a friable lipomatous tumor.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Testicular Diseases / pathology. Testicular Neoplasms / pathology. Xanthogranuloma, Juvenile / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Male

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  • (PMID = 18538690.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Ribatti D, Belloni AS, Nico B, Di Comite M, Crivellato E, Vacca A: Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma. Peptides; 2008 Sep;29(9):1596-602
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent evidence in vitro and in vivo indicates that leptin, an adipose tissue-secreted hormone which is involved in the regulation of satiety, metabolic rate and thermogenesis, is implicated in angiogenesis.
  • However, the role of leptin-mediated angiogenesis in hepatic carcinogenesis has not yet been completely elucidated.
  • In this study, we have correlated microvascular density and leptin/leptin receptor (Ob-R) expression in endothelial and tumor cells with the histopathological type in human hepatocellular carcinoma (HCC).
  • Poorly-differentiated HCC had a higher degree of vascularization than other stages and leptin/Ob-R expression in both tumor and endothelial cells increased in parallel with the grade of malignancy and was highly correlated with the degree of angiogenesis.
  • Taken together, these findings indicate that leptin/Ob-R correlate with angiogenesis and tumor progression in patients with HCC and that an anti-leptin antibody exerts an angiostatic activity in HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / physiopathology. Leptin / biosynthesis. Liver Neoplasms / physiopathology. Neovascularization, Pathologic / physiopathology. Receptors, Leptin / biosynthesis

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  • (PMID = 18573568.001).
  • [ISSN] 0196-9781
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin; 0 / Receptors, Leptin
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12. Cunningham KS, Veinot JP, Feindel CM, Butany J: Fatty lesions of the atria and interatrial septum. Hum Pathol; 2006 Oct;37(10):1245-51
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  • [Title] Fatty lesions of the atria and interatrial septum.
  • Lipomatous lesions of the heart involving the atria and interatrial septum are not well known.
  • Most such lesions do not become clinically significant; however, intractable arrhythmias, blood flow obstruction, and valvular disruption may result from extensive fatty infiltration of the atrial wall or from the mass effect of benign or malignant lipomatous tumors.
  • Some fatty lesions may be difficult to characterize radiologically, and misdiagnosis may lead to unnecessary surgical interventions.
  • We describe the pathology of the most common fatty lesions and underscore some of the radiographic and surgical issues pertaining to the diagnosis and management of these masses.
  • [MeSH-major] Adipose Tissue / pathology. Heart Atria / pathology. Heart Neoplasms / pathology. Heart Septum / pathology. Lipoma / pathology. Liposarcoma / pathology

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  • (PMID = 16949930.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Li T, Wang L, Yu HH, Sun HC, Qin LX, Ye QH, Fan J, Tang ZY: Hepatic angiomyolipoma: a retrospective study of 25 cases. Surg Today; 2008;38(6):529-35
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  • PURPOSE: We report our experience of diagnosing and treating hepatic angiomyolipoma (HAML), a rare benign mesenchymal tumor.
  • All tumors were composed of varying proportions of smooth muscle, adipose tissue, and blood vessels, and showed positive immunohistochemical staining for HMB-45.
  • The definitive diagnosis of HAML is challenging and depends on the presence of HMB-45-positive myoid cells.
  • [MeSH-major] Angiomyolipoma / diagnosis. Angiomyolipoma / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / analysis. Female. Hepatectomy. Humans. Magnetic Resonance Imaging. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Prognosis. Retrospective Studies. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 18516533.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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14. Rajeswaran R, Murthy J, Chandrasekharan A, Joseph S: Case Report: Congenital infiltrating lipomatosis of face. Indian J Radiol Imaging; 2008 Nov;18(4):306-9
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  • Congenital infiltrating lipomatosis of the face is a rare condition characterized by diffuse fatty infiltration of the facial soft tissues.
  • It is a type of lipomatous tumor that is congenital in origin; it is rare and seen usually in childhood.

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  • (PMID = 19774187.001).
  • [ISSN] 0971-3026
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2747453
  • [Keywords] NOTNLM ; Congenital / lipomatosis
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15. Ide F, Shimoyama T, Kaneko T, Horie N: Pacinian neuroma in adipose herniation of the buccal mucosa. Int J Oral Maxillofac Surg; 2006 Dec;35(12):1162-3
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  • [Title] Pacinian neuroma in adipose herniation of the buccal mucosa.
  • An interesting case of a trauma-induced tender mass of the buccal mucosa in a 45-year-old man was presented.
  • Microscopically, the mature adipose tissue is unique in that it contained a single enlarged Pacinian corpuscle near the deep margin.
  • [MeSH-major] Adipose Tissue / pathology. Mouth Neoplasms / pathology. Neuroma / pathology. Pacinian Corpuscles / pathology

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  • (PMID = 17008055.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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16. Prado CM, Birdsell LA, Baracos VE: The emerging role of computerized tomography in assessing cancer cachexia. Curr Opin Support Palliat Care; 2009 Dec;3(4):269-75
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  • PURPOSE OF REVIEW: The present review represents an overview of the potential opportunistic use of computerized tomography (CT) to enhance our understanding of abnormal body composition, specifically lean and adipose tissue changes in cancer cachexia.
  • RECENT FINDINGS: One of the characteristics of cancer cachexia is the depletion of muscle with or without adipose tissue loss.
  • Therefore, a body composition tool that specifically distinguishes between these tissues is essential in assessing this syndrome.
  • Cancer patients are routinely evaluated by high resolution imaging such as CT for the purpose of diagnosis and follow-up.
  • Recent work exploiting CT images for body composition analysis has revealed the natural history of cancer cachexia, including progressive alterations in skeletal muscle, adipose tissue, organs, and tumor mass.
  • CT-based quantification of skeletal muscle has permitted identification of individuals with sarcopenia, and links between sarcopenia and functional status, chemotherapy toxicity, time to tumor progression, and mortality.
  • SUMMARY: CT images routinely acquired from health records of cancer patients can be used to quantify specific lean and adipose tissues, to interpret body composition in population-based studies, and to evaluate individual patients in a clinical and therapeutic decision-making setting.
  • [MeSH-major] Body Composition. Cachexia / radiography. Neoplasms / complications
  • [MeSH-minor] Adipose Tissue / radiography. Disease Progression. Humans. Muscle, Skeletal / radiography. Thinness / etiology. Thinness / physiopathology. Thinness / radiography. Tomography, X-Ray Computed

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  • (PMID = 19667996.001).
  • [ISSN] 1751-4266
  • [Journal-full-title] Current opinion in supportive and palliative care
  • [ISO-abbreviation] Curr Opin Support Palliat Care
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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17. Sarzani R, Bordicchia M, Marcucci P, Bedetta S, Santini S, Giovagnoli A, Scappini L, Minardi D, Muzzonigro G, Dessì-Fulgheri P, Rappelli A: Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients. Metabolism; 2009 Mar;58(3):361-7
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  • [Title] Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients.
  • In overweight patients (OW), the increased peripheral activity of the endocannabinoid system in visceral adipose tissue (VAT) may be mediated by cannabinoid type 1 (CB1) receptor expression.
  • We determined whether CB1 receptor splice variants and messenger RNA (mRNA) levels in perirenal and subcutaneous adipose tissues are associated with obesity and metabolic syndrome (MetS).
  • Gene expression with multiple-primers real-time polymerase chain reaction (TaqMan; Applied Biosystem, Weiterstadt, Germany) was performed to study VAT and paired subcutaneous adipose tissue (SAT) mRNA from 36 consecutive patients undergoing nephrectomy.
  • In addition, patients with the MetS (n = 22) showed higher CB1 expression in perirenal adipose tissues (P = .007).
  • Visceral adipose CB1 expression correlated with BMI.
  • [MeSH-major] Adipose Tissue / physiopathology. Body Mass Index. Metabolic Diseases / physiopathology. Overweight / physiopathology. Receptor, Cannabinoid, CB1 / genetics
  • [MeSH-minor] Alternative Splicing. Body Weight / genetics. DNA, Single-Stranded / genetics. Exons. Gene Expression Regulation. Genetic Variation. Humans. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology. Metabolic Syndrome X / genetics. Obesity / genetics. RNA, Messenger / genetics

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  • (PMID = 19217452.001).
  • [ISSN] 1532-8600
  • [Journal-full-title] Metabolism: clinical and experimental
  • [ISO-abbreviation] Metab. Clin. Exp.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Single-Stranded; 0 / RNA, Messenger; 0 / Receptor, Cannabinoid, CB1
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18. Tassenoy A, De Mey J, Stadnik T, De Ridder F, Peeters E, Van Schuerbeek P, Wylock P, Van Eeckhout GP, Verdonck K, Lamote J, Baeyens L, Lievens P: Histological findings compared with magnetic resonance and ultrasonographic imaging in irreversible postmastectomy lymphedema: a case study. Lymphat Res Biol; 2009;7(3):145-51
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  • Ultrasonography (US) is a harmless, cheap, and easily applicable technique to visualize the dermal and subcutaneous tissue, but interpretation of the obtained images is not always evident.
  • The aim of this study was to compare ultrasound images of irreversible edema with tissue histology, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).
  • Ultrasonographic images of the edematous dermis show an homogeneous hypoechogenic dermal layer that appears on tissue histology to be less compact, due to the excess of fluid in the interstitium separating the collagen fibres and making it more transparent on light microscopy.
  • In the subcutis, increase of the adipose tissue could be observed on US, MRI, and tissue histology.
  • Hypoechogenic areas near the muscle fascia are registered on US corresponding with epifascial fluid on MRI, and hyperechogenic branches are embedded within the adipose tissue, on tissue histology seen as large fibrotic septa enclosing adipose cells.
  • [MeSH-major] Breast Neoplasms / complications. Breast Neoplasms / surgery. Lymphedema / complications. Lymphedema / pathology. Magnetic Resonance Imaging / methods. Mastectomy. Ultrasonography / methods


19. Tanas MR, Rubin BP, Tubbs RR, Billings SD, Downs-Kelly E, Goldblum JR: Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience. Arch Pathol Lab Med; 2010 Dec;134(12):1797-803
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  • [Title] Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience.
  • CONTEXT: Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH).
  • OBJECTIVE: To determine the utility of FISH in the diagnosis of mesenchymal neoplasms.
  • DESIGN: Two hundred thirty soft tissue cases analyzed by FISH were reviewed retrospectively.
  • RESULTS: Morphologic patterns where FISH was used included high-grade round cell sarcomas (n  =  67), nonmyogenic spindle cell sarcomas (n  =  40), low-grade myxoid neoplasms (n  =  34), adipocytic neoplasms (n  =  20), and melanocytic neoplasms (n  =  19).
  • Fifty cases did not fit into the previously mentioned categories.
  • SYT FISH (96% of monophasic synovial sarcomas were positive; 0% of malignant peripheral nerve sheath tumor were positive) and DDIT3 FISH (100% of myxoid/round cell liposarcomas; no other neoplasm positive) were very sensitive and specific.
  • EWSR1 FISH was very sensitive and specific in the differential diagnosis of melanocytic neoplasms (88% of clear cell sarcomas were positive; all melanomas were negative).
  • EWSR1 FISH was sensitive among high-grade round cell sarcomas (positive in 100% of desmoplastic small round cell tumors and 96% of Ewing sarcoma/primitive neuroectodermal tumors) but not specific because clear cell sarcoma, extraskeletal myxoid chondrosarcoma, and a subset of round cell liposarcomas also harbor rearrangements of EWSR1.
  • FUS FISH was very sensitive in detecting low-grade fibromyxoid sarcomas (91% positive) but not specific because most myxoid/round cell liposarcomas also contain rearrangements of FUS.
  • All atypical lipomatous tumors were positive for amplification of MDM2, whereas all lipomas were negative.
  • CONCLUSION: FISH is a useful adjunct in the diagnosis of mesenchymal neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Melanoma / diagnosis. Neoplasms, Adipose Tissue / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Chromosome Aberrations. Humans. Molecular Diagnostic Techniques


20. Shumaker NR, Rochman CM, Legallo RD, Northup CJ, Hanks JB: Incidentally identified adrenal lipoma: case report and review of related literature. Endocr Pract; 2008 Mar;14(2):209-12
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  • METHODS: The clinical, computed tomographic, and magnetic resonance imaging findings in this patient are described, and the pathologic features of the tumor are characterized.
  • After laparoscopic left adrenalectomy, pathologic examination revealed a well-circumscribed, fatty, 7-cm adrenocortical-based tumor, which weighed 135 g.
  • Histologic sampling disclosed mature adipose tissue without evidence of myeloid heterotopy or features of malignant involvement, and adrenal lipoma was diagnosed.
  • On the basis of our review of the English-language literature, this tumor is the 11th reported case of adrenal lipoma.
  • The vast majority of these tumors have been asymptomatic and identified incidentally on imaging or at autopsy.
  • CONCLUSION: With the increased utilization and sensitivity of abdominal imaging techniques, identification of nonfunctional adrenal tumors has become more frequent.
  • Adrenal lipoma should be included in the differential diagnosis of lipomatous adrenal tumors.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Lipoma / diagnosis

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  • (PMID = 18308660.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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21. Theumann N, Abdelmoumene A, Wintermark M, Schnyder P, Gailloud MC, Resnick D: Posttraumatic pseudolipoma: MRI appearances. Eur Radiol; 2005 Sep;15(9):1876-80
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  • MRI examinations were interpreted in consensus by two experienced musculoskeletal radiologists with attention to fatty extension (subcutaneous fatty thickness and anatomical extension), asymmetry compared with the asymptomatic side, the presence or absence of fibrous septae or nonfatty components, and patterns of contrast enhancement.
  • Clinically, they showed as subcutaneous masses with the consistency of normal adipose tissue.
  • On MRI examinations, using the contralateral side as a control, pseudolipomas appeared as focal fatty masses without a capsule or contrast enhancement.
  • Posttraumatic pseudolipomas may develop at a site of blunt trauma or surgical procedures often antedated by a soft tissue hematoma.
  • Characteristic MRI findings are unencapsulated subcutaneous fatty masses without contrast enhancement.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging. Soft Tissue Injuries / complications. Soft Tissue Neoplasms / diagnosis. Wounds, Nonpenetrating / complications
  • [MeSH-minor] Adipose Tissue / pathology. Adolescent. Adult. Contrast Media. Female. Follow-Up Studies. Hematoma / complications. Humans. Image Enhancement. Lipectomy. Male. Middle Aged. Postoperative Complications. Retrospective Studies

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  • [CommentIn] Eur Radiol. 2006 Jun;16(6):1399; discussion 1400 [16437235.001]
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  • (PMID = 15841381.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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22. Ardeshirpour F, Shockley WW, Zdanski CJ: Lipoblastoma in the masticator space of an infant. Eur J Pediatr Surg; 2010 May;20(3):201-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Facial Neoplasms / surgery. Neoplasms, Adipose Tissue / surgery

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  • (PMID = 19866417.001).
  • [ISSN] 1439-359X
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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23. Demir MK, Unlu E, Usta U: A curious mass of the anterior compartment in the knee. Br J Radiol; 2009 May;82(977):435-7
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  • [MeSH-major] Chondroma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adipose Tissue. Female. Humans. Knee / radiography. Magnetic Resonance Imaging / methods. Middle Aged. Patella. Tomography, X-Ray Computed / methods

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  • (PMID = 19386962.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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24. Grant L, Moyle P, Griffin N, Williams M, Sala E, Vasconcelos J, Dixon A: Visceral abdominal obesity--is there an increased prevalence in men presenting with testicular teratoma? Acta Radiol; 2010 Jul;51(6):687-92
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  • BACKGROUND: There is evidence to suggest a link between the accumulation of visceral abdominal adipose tissue and an increased incidence of prostate, endometrial, breast, and colonic cancer.
  • PURPOSE: To investigate whether an increase in ratio of visceral to subcutaneous abdominal adipose tissue is demonstrated in patients with testicular teratoma.
  • Abdominal adipose tissue distribution for these 22 patients was compared with that of 22 control patients, standardized for age, sex, and body mass index.
  • Visceral and subcutaneous adipose tissue volumes were calculated from a single axial CT slice at the level of the umbilicus.
  • CONCLUSION: Patients with testicular teratoma have a relatively greater proportion of abdominal visceral adipose tissue compared with controls.
  • [MeSH-major] Intra-Abdominal Fat / pathology. Obesity, Abdominal / epidemiology. Teratoma / etiology. Testicular Neoplasms / etiology

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  • (PMID = 20380607.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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25. Veinot JP: Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node. Semin Diagn Pathol; 2008 Feb;25(1):29-38
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  • [Title] Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node.
  • Lipomatous lesions of the heart and cystic tumor of the atrioventricular node are not common.
  • A pathologist will only rarely encounter these entities, and in the case of the atrioventricular node tumor, only if they examine the conduction system.
  • Most fatty lesions are not clinically significant; however, arrhythmias, blood flow obstruction, and valvular dysfunction may result from benign or malignant lipomatous tumors.
  • Cystic tumor of the atrioventricular node has been implicated in the causation of sudden cardiac death, and there has been much academic interest concerning its cell of origin.
  • [MeSH-major] Adipocytes / pathology. Atrioventricular Node / pathology. Heart Neoplasms / pathology. Neoplasms, Adipose Tissue / pathology

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  • (PMID = 18350920.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Reddy MP, Ramaswamy MR: FDG uptake in brown adipose tissue mimicking an adrenal metastasis: source of false-positive interpretation. Clin Nucl Med; 2005 Apr;30(4):257-8
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  • [Title] FDG uptake in brown adipose tissue mimicking an adrenal metastasis: source of false-positive interpretation.
  • Brown adipose tissue (BAT) uptake of F-18 fluorodeoxyglucose (FDG) poses a significant challenge to positron emission tomography interpretation.
  • BAT is not only localized to the supraclavicular areas, but is also seen in the neck, mediastinum, axillae, costovertebral junctions, and retrocrural and periadrenal regions.
  • [MeSH-major] Adipose Tissue, Brown / metabolism. Adipose Tissue, Brown / radionuclide imaging. Diagnostic Errors / prevention & control. Fluorodeoxyglucose F18 / pharmacokinetics. Lung Neoplasms / metabolism. Lung Neoplasms / radionuclide imaging
  • [MeSH-minor] Adrenal Gland Neoplasms / metabolism. Adrenal Gland Neoplasms / radionuclide imaging. Adrenal Gland Neoplasms / secondary. Diagnosis, Differential. False Positive Reactions. Female. Humans. Middle Aged. Radiopharmaceuticals / pharmacokinetics

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  • (PMID = 15764884.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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27. Lăzureanu C, Baderca F, Burlacu O, Nicodin A: Soft tissue epithelioid angiosarcoma. Rom J Morphol Embryol; 2010;51(4):787-92
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  • [Title] Soft tissue epithelioid angiosarcoma.
  • The preoperative native and with contrast substance CT revealed a tumor mass extended from the right paravertebral muscles to the diaphragmatic right pillar muscle, invading the postero-basal pleura and the posterior arches of the right XIth and 12th ribs with osteolysis.
  • Fragments of 10 cm large tumor resection specimen (striated muscle, dense connective tissue, adipose tissue, lymph nodes and intercostals nerves) were routinely processed, further immunohistochemical investigations were needed, using Dako antibodies pan-CK clone MNF116, CD34, CD20, vimentin, synaptophysin, melanoma HMB45 clone, with LSAB 2Kits system and further CK AE1÷AE3, CK7, CK20, CEA, S-100 protein, CD31, von Willebrand factor, D2-40÷podoplanin, Ki-67 antigen, with EnVision system and DAB visualization in both systems.
  • The histological and immunohistochemical aspects were indicative for soft tissue epithelioid angiosarcoma, which was misdiagnosed on frozen and HE sections as a carcinoma, because of the cohesiveness and nesting properties of the malignant cells, together with the presence of lymph node metastases.
  • The tumor locally recurred 12 months afterwards, but the patient is still alive 22 months after surgery.
  • [MeSH-major] Hemangiosarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Diagnostic Errors. Epithelioid Cells / metabolism. Epithelioid Cells / pathology. Humans. Immunohistochemistry. Male. Middle Aged. Thoracic Neoplasms / diagnosis. Thoracic Neoplasms / metabolism. Thoracic Neoplasms / pathology

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  • (PMID = 21103644.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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28. Shimada S, Harada H, Ishizawa K, Hirose T: Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma. Pathol Int; 2006 Oct;56(10):638-41
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  • [Title] Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma.
  • A 16 x 13 cm lipomatous tumor was resected from the perirenal retroperitoneum of a 71-year-old woman.
  • Microscopically, the tumor was exclusively composed of mature adipose tissue and abnormal thick blood vessels, but bundles of smooth muscle were lacking.
  • Real-time polymerase chain reaction failed to demonstrate the amplification of the murine double-minute type 2 gene and cyclin-dependent kinase 4 gene in this tumor.
  • Therefore, the tumor was diagnosed as lipomatous angiomyolipoma.
  • After the diagnosis, it was found that the patient had multiple myeloma and cardiac amyloidosis, suggesting that the amyloid deposition within the tumor was a complication of the myeloma.
  • Lipomatous angiomyolipoma may be a diagnostic pitfall of retroperitoneal lipomatous tumors.
  • [MeSH-major] Amyloid / metabolism. Angiomyolipoma / diagnosis. Angiomyolipoma / metabolism. Liposarcoma / diagnosis. Liposarcoma / metabolism. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / metabolism
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase 4 / genetics. Cyclin-Dependent Kinase 4 / metabolism. Diagnosis, Differential. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism

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  • (PMID = 16984623.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Amyloid; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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29. Vona-Davis L, Howard-McNatt M, Rose DP: Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer. Obes Rev; 2007 Sep;8(5):395-408
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  • Upper body obesity and the related metabolic disorder type 2 diabetes have been identified as risk factors for breast cancer, and associated with late-stage disease and a poor prognosis.
  • Obesity, type 2 diabetes and the metabolic syndrome also have in common an increased production of leptin and a decreased production of adiponectin by adipose tissue, with consequent elevations and reductions, respectively, in the circulating levels of these two adipokines.
  • These changes in plasma leptin and adiponectin, acting through endocrine and paracrine mechanisms, have been associated in several studies with an increase in breast cancer risk and, perhaps, to more aggressive tumours; studies in vitro showed that leptin stimulates, and adiponectin inhibits, tumour cell proliferation and the microvessel angiogenesis which is essential for breast cancer development and progression.
  • [MeSH-major] Body Composition / physiology. Breast Neoplasms / etiology. Diabetes Mellitus, Type 2 / complications. Metabolic Syndrome X / complications. Obesity / complications


30. Novikov VV, Novikov GV, Fesenko EE: Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics; 2009 Jul;30(5):343-51
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  • [Title] Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma.
  • It was shown that the exposure of mice with EAC to combined MFs causes structural changes in some organs (liver, adrenal glands), which are probably due to the total degradation of the tumor tissue.
  • In mice with transplanted EAC, the tumor tissue after exposure to weak MFs was practically absent, as distinct from control animals in which the invasion of the tumor into the adipose tissue surrounding the kidneys, mesenteric lymph nodes, and spermatic appendages was observed.
  • In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism.
  • [MeSH-major] Carcinoma, Ehrlich Tumor / pathology. Carcinoma, Ehrlich Tumor / therapy. Magnetic Field Therapy / methods. Magnetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19267367.001).
  • [ISSN] 1521-186X
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Fujimoto-Ouchi K, Onuma E, Shirane M, Mori K, Tanaka Y: Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models. Cancer Chemother Pharmacol; 2007 May;59(6):807-15
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  • METHODS: From two colon 26 sublines-cancer cachectic clone20 and non-cachectic clone5 plasma levels of PTHrP protein and mRNA expression levels in tumor tissues were compared.
  • The expression level of PTHrP mRNA was 49-fold higher in tumor tissues of clone20 than of clone5, according to GeneChip analysis.
  • PTHrP antibody as well as IL-6 antibody suppressed wasting of the body and gastrocnemius and adipose tissue weights.
  • PTHrP antibody suppressed the induction of hypercalcemia but not hypoglycemia or elevation of IL-6, whereas IL-6 antibody suppressed the induction of hypoglycemia but not hypercalcemia or elevation of PTHrP.
  • Capecitabine, a fluorinated pyrimidine anticancer agent, improved body wasting of mice bearing clone20 at a low dose with no reduction of tumor volume.
  • [MeSH-major] Cachexia / drug therapy. Colonic Neoplasms / complications. Deoxycytidine / analogs & derivatives. Fluorouracil / analogs & derivatives. Interleukin-6 / blood. Parathyroid Hormone-Related Protein / blood
  • [MeSH-minor] Animals. Capecitabine. Cell Line. Hypercalcemia / prevention & control. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Tumor Cells, Cultured. Weight Loss

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  • (PMID = 17009035.001).
  • [ISSN] 0344-5704
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Interleukin-6; 0 / Parathyroid Hormone-Related Protein; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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32. Melendez-Zajgla J, Del Pozo L, Ceballos G, Maldonado V: Tissue inhibitor of metalloproteinases-4. The road less traveled. Mol Cancer; 2008;7:85
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  • [Title] Tissue inhibitor of metalloproteinases-4. The road less traveled.
  • Tissue inhibitors of metalloproteinases (TIMPs) regulate diverse processes, including extracellular matrix (ECM) remodeling, and growth factors and their receptors' activities through the inhibition of matrix metalloproteinases (MMPs).
  • Initially cloned in human and, later, in mouse, TIMP-4 expression is restricted to heart, kidney, pancreas, colon, testes, brain and adipose tissue.
  • [MeSH-major] Tissue Inhibitor of Metalloproteinases / chemistry. Tissue Inhibitor of Metalloproteinases / metabolism
  • [MeSH-minor] Animals. Disease Progression. Gene Expression Regulation, Enzymologic. Humans. Matrix Metalloproteinases / metabolism. Neoplasms / enzymology. Neoplasms / pathology. Organ Specificity

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  • (PMID = 19025595.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinases; 0 / tissue inhibitor of metalloproteinase-4; EC 3.4.24.- / Matrix Metalloproteinases
  • [Number-of-references] 88
  • [Other-IDs] NLM/ PMC2599898
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33. Craver RD, Henrich S, Kao YS: Fibrous lipoblastoma with 8q11.2 abnormality. Cancer Genet Cytogenet; 2006 Dec;171(2):112-4
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  • [Title] Fibrous lipoblastoma with 8q11.2 abnormality.
  • A 3-month-old African American female infant had a rapidly growing lipoblastoma with a prominent fibrous component in the soft tissue of the left lateral knee, which recurred at 10 months.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8. Neoplasms, Adipose Tissue / genetics. Neoplasms, Adipose Tissue / pathology. Neoplasms, Fibrous Tissue / genetics. Neoplasms, Fibrous Tissue / pathology
  • [MeSH-minor] Chromosome Deletion. Chromosomes, Human, Pair 19. Female. Humans. Infant. Knee. Neoplasm Recurrence, Local / genetics. Translocation, Genetic

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  • (PMID = 17116489.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Pamuk GE, Demir M, Harmandar F, Yesil Y, Turgut B, Vural O: Leptin and resistin levels in serum of patients with hematologic malignancies: correlation with clinical characteristics. Exp Oncol; 2006 Sep;28(3):241-4
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  • CONCLUSION: We found higher leptin levels in MM and CLL patients, and higher resistin levels in lymphoma patients: this fact demonstrates that changes in adipose tissue and metabolism occur in these disease states.
  • [MeSH-major] Hematologic Neoplasms / metabolism. Leptin / blood. Resistin / blood
  • [MeSH-minor] Adipose Tissue / metabolism. Adult. Aged. Female. Humans. Lipid Metabolism. Male. Middle Aged

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  • (PMID = 17080020.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Leptin; 0 / Resistin
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35. Schäffler A, Fürst A, Büchler C, Paul G, Rogler G, Schölmerich J, Herfarth H: Vascular endothelial growth factor secretion from mesenteric adipose tissue and from creeping fat in Crohn's disease. J Gastroenterol Hepatol; 2006 Sep;21(9):1419-23
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  • [Title] Vascular endothelial growth factor secretion from mesenteric adipose tissue and from creeping fat in Crohn's disease.
  • BACKGROUND: Creeping fat represents a characteristic feature of Crohn's disease (CD), and adipose tissue secretes adipocytokines and chemokines/growth factors such as vascular endothelial growth factor (VEGF).
  • MATERIAL AND METHODS: Adipose tissue was obtained from creeping fat of 10 patients with CD.
  • Mesenteric adipose tissue was resected from 13 patients with colon cancer (CC) and from seven patients with diverticulitis (DIV).
  • Three fat tissue specimens per well, and several wells (6-8) per patient were incubated ex vivo for 24 h.
  • RESULTS: There was stable VEGF secretion from mesenteric adipose tissue of patients with CC or DIV and from creeping fat of patients with CD.
  • Whereas the VEGF secretion rate was not different between patients with CD (465 +/- 98 pg/g fat per 24 h) and CC (399 +/- 48 pg/g fat per 24 h), VEGF secretion was significantly reduced in patients suffering from DIV (115 +/- 41 pg/g fat per 24 h; P < 0.0001 and P = 0.001, respectively).
  • The CD patients treated with steroids had significantly lower VEGF secretion rates (294 +/- 42 pg/g fat per 24 h) than CD patients not receiving steroids (607 +/- 105 pg/g fat per 24 h; P = 0.001).
  • [MeSH-major] Adipose Tissue / secretion. Crohn Disease / metabolism. Mesentery. Vascular Endothelial Growth Factor A / secretion
  • [MeSH-minor] Adult. Aged. Animals. Colonic Neoplasms / metabolism. Diverticulitis / metabolism. Female. Humans. Male. Middle Aged. Steroids / therapeutic use


36. Giblin E, Lynn D, Mortman K: Cervical hibernoma demonstrating uptake on Tc-99m lymphoscintigraphy. Clin Nucl Med; 2006 Nov;31(11):694-6
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  • A hibernoma is an uncommon, benign tumor composed of brown adipose tissue.
  • Hibernomas may be first diagnosed not by clinical examination, but incidentally through radiologic tests assessing the metabolic activity of certain tissues.
  • These tumors are by definition benign entities but, given their propensity for growth over time, they require complete extirpation to prevent recurrence.
  • [MeSH-major] Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / radionuclide imaging. Lipoma / metabolism. Lipoma / radionuclide imaging. Technetium Tc 99m Sulfur Colloid / pharmacokinetics
  • [MeSH-minor] Female. Humans. Middle Aged. Radiopharmaceuticals / pharmacokinetics. Tissue Distribution

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  • (PMID = 17053387.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 556Q0P6PB1 / Technetium Tc 99m Sulfur Colloid
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37. Sera H, Shimoda T, Ozeki S, Honda T: A case of chondroma of the tongue. Int J Oral Maxillofac Surg; 2005 Jan;34(1):99-100
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  • Chondroma of the tongue represents a very rare benign tumor at this site, with very few reports of pure chondroma (no components of adipose, fibrous or bony tissue) existing.
  • This report presents the case of a 17-year-old man with chondroma arising at the center of the tongue.
  • [MeSH-major] Chondroma / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 15617977.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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38. Wolfram S, Raederstorff D, Preller M, Wang Y, Teixeira SR, Riegger C, Weber P: Epigallocatechin gallate supplementation alleviates diabetes in rodents. J Nutr; 2006 Oct;136(10):2512-8
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  • As the prevalence of type 2 diabetes mellitus is increasing at an alarming rate, effective nutritional and exercise strategies for the prevention of this disease are required.
  • Using gene microarray and real-time quantitative RT-PCR we investigated the effect of EGCG on gene expression in H4IIE rat hepatoma cells as well as in liver and adipose tissue of db/db mice.
  • In H4IIE cells, EGCG downregulated genes involved in gluconeogenesis and the synthesis of fatty acids, triacylgycerol, and cholesterol.
  • EGCG decreased the mRNA expression of phosphoenolpyruvate carboxykinase in H4IIE cells as well as in liver and adipose tissue of db/db mice.
  • [MeSH-minor] Acyl-CoA Oxidase / genetics. Adipose Tissue / enzymology. Animals. Blood Glucose / analysis. Carnitine O-Palmitoyltransferase / genetics. Cell Line, Tumor. Dietary Supplements. Gene Expression / genetics. Gene Expression Regulation / drug effects. Glucokinase / genetics. Glucose / metabolism. Glucose Tolerance Test. Lipid Metabolism / genetics. Liver / enzymology. Liver Neoplasms, Experimental. Male. Mice. Mice, Inbred C57BL. Oligonucleotide Array Sequence Analysis. Phosphoenolpyruvate Carboxykinase (GTP) / genetics. RNA, Messenger. Rats. Rats, Sprague-Dawley

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  • (PMID = 16988119.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / RNA, Messenger; 8R1V1STN48 / Catechin; BQM438CTEL / epigallocatechin gallate; EC 1.3.3.6 / Acyl-CoA Oxidase; EC 2.3.1.21 / Carnitine O-Palmitoyltransferase; EC 2.7.1.2 / Glucokinase; EC 4.1.1.32 / Phosphoenolpyruvate Carboxykinase (GTP); IY9XDZ35W2 / Glucose
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39. Yague JG, Garcia-Segura LM, Azcoitia I: Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells. Endocrine; 2009 Apr;35(2):252-61
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  • Its regulation has been studied in cells from multiple origins, including placenta, bone, adipose tissue, and breast cancer.
  • The results show that these compounds enhance the activity of different aromatase promoters in glioma cells, but not in neuroblastoma and breast cancer cells.
  • Vitamin D increased the expression of I.3, I.7, and I.4 aromatase transcripts and induced de novo expression of the I.6 transcript; dexamethasone increased the expression of I.4, PII, and I.3 transcripts and mifepristone increased the expression of PII and I.3 aromatase transcripts.
  • [MeSH-minor] Breast Neoplasms / enzymology. Cell Line, Tumor. Glucocorticoids / pharmacology. Humans. Neuroblastoma / enzymology. Promoter Regions, Genetic / genetics. Receptors, Glucocorticoid / antagonists & inhibitors. Transcription, Genetic / drug effects

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  • (PMID = 19116788.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Receptors, Glucocorticoid; 1406-16-2 / Vitamin D; 320T6RNW1F / Mifepristone; 7S5I7G3JQL / Dexamethasone; EC 1.14.14.1 / Aromatase
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40. Zankl M, Fill U, Hoeschen C, Panzer W, Regulla D: Average glandular dose conversion coefficients for segmented breast voxel models. Radiat Prot Dosimetry; 2005;114(1-3):410-4
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  • For 8 voxel models of a compressed breast (4-7 cm thickness and two orientations for each thickness) and 14 radiation qualities commonly used in mammography (HVL 0.28-0.50 mm Al), tissue dose conversion coefficients were calculated for a focus-to-film distance of 60 cm using Monte Carlo methods.
  • The contents of glandular tissues amounted to 2.6%, and were asymmetrically distributed with regard to the midplane of the model.
  • The calculated tissue dose conversion coefficients were compared with the recent literature values.
  • These earlier tissue dose conversion coefficients were also calculated using Monte Carlo methods and breast models of various thickness, but these consist of homogeneous mixtures of glandular and adipose tissues embedded in 5 mm pure adipose tissue both at the entrance and exit sides.
  • The results show that the new glandular tissue dose conversion coefficients agree well with the literature values for those cases where the glandular tissue is predominantly concentrated in the upper part of the model.
  • These findings reveal a basic problem in patient dosimetry for mammography: glandular dose is not only governed by the average breast composition, which could be derived from the breast thickness, but also by the local distribution of glandular tissue within the breast, which is not known.
  • [MeSH-minor] Air. Breast Neoplasms / pathology. Female. Humans. Monte Carlo Method. Phantoms, Imaging. Radiation Dosage. Radiometry. Radiotherapy Planning, Computer-Assisted. Tomography, X-Ray Computed. X-Ray Intensifying Screens

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  • (PMID = 15933148.001).
  • [ISSN] 0144-8420
  • [Journal-full-title] Radiation protection dosimetry
  • [ISO-abbreviation] Radiat Prot Dosimetry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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41. Safi R, Kovacic A, Gaillard S, Murata Y, Simpson ER, McDonnell DP, Clyne CD: Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. Cancer Res; 2005 Dec 15;65(24):11762-70
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  • Aromatase inhibitors target the production of estrogen in breast adipose tissue, but in doing so, also decrease estrogen formation in bone and other sites, giving rise to deleterious side effects, such as bone loss and arthralgia.
  • In this regard, we have determined that the orphan nuclear receptor liver receptor homologue-1 (LRH-1) is a specific transcriptional activator of aromatase gene expression in human breast preadipocytes but not in other tissues of postmenopausal women.
  • The importance of this finding was confirmed by showing that LRH-1-dependent, PGC-1alpha-stimulated regulation of aromatase gene expression in primary human breast preadipocytes was effectively suppressed by RXR agonists.
  • [MeSH-minor] Adipocytes / cytology. Adipocytes / drug effects. Adipocytes / metabolism. Animals. Antineoplastic Agents / pharmacology. Estrogens / metabolism. HeLa Cells. Humans. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Liver Neoplasms / therapy. Mice. Peptide Fragments / pharmacology. Transcription, Genetic. Tretinoin / pharmacology

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  • (PMID = 16357189.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK62434
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA-Binding Proteins; 0 / Estrogens; 0 / Heat-Shock Proteins; 0 / NR5A2 protein, human; 0 / Nr5a2 protein, mouse; 0 / PPARGC1A protein, human; 0 / Peptide Fragments; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Retinoid X Receptor alpha; 0 / Transcription Factors; 5300-03-8 / alitretinoin; 5688UTC01R / Tretinoin; EC 1.14.14.1 / Aromatase
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42. Tisdale MJ: Mechanisms of cancer cachexia. Physiol Rev; 2009 Apr;89(2):381-410
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  • Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a shortened survival time.
  • Anorexia often accompanies cachexia, but appears not to be responsible for the tissue loss, particularly lean body mass.
  • Loss of adipose tissue is due to an increased lipolysis by tumor or host products.
  • Tumor factors such as proteolysis-inducing factor and host factors such as tumor necrosis factor-alpha, angiotensin II, and glucocorticoids can all induce muscle atrophy.
  • Knowledge of the mechanisms of tissue destruction in cachexia should improve methods of treatment.
  • [MeSH-major] Cachexia / physiopathology. Neoplasms / physiopathology
  • [MeSH-minor] Adipose Tissue / metabolism. Adipose Tissue / pathology. Atrophy. Energy Metabolism / physiology. Humans. Muscle, Skeletal / metabolism. Muscle, Skeletal / pathology

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  • (PMID = 19342610.001).
  • [ISSN] 0031-9333
  • [Journal-full-title] Physiological reviews
  • [ISO-abbreviation] Physiol. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 299
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43. Basten O, Bandorski D, Bismarck C, Neumann K, Fisseler-Eckhoff A: [Acetone compression. A fast, standardized method to investigate gastrointestinal lymph nodes]. Pathologe; 2010 May;31(3):218-24
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  • Lymph node staging is the most important prognostic parameter in malignant gastrointestinal tumors.
  • Manual dissection of adipose tissue is time-consuming and also depends on the experience of the individual examiner.
  • By combining elution with acetone and mechanical compression using simple equipment it was possible to completely embed adipose tissue from 404 surgical specimens (colon 348, stomach 28, greater omentum 14, other location 14) without manual dissection.
  • As a result of the procedure, the weight of the adipose tissue could be reduced by 90%-95%, making full histological examination possible.
  • Elution with acetone enables the prompt, standardized and full histological work-up of adipose tissue without manual dissection.
  • [MeSH-major] Acetone. Gastrointestinal Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Colonic Neoplasms / pathology. Humans. Immunohistochemistry / methods. Neoplasm Staging / methods. Prognosis. Stomach Neoplasms / pathology

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  • (PMID = 20012620.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 1364PS73AF / Acetone
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44. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Marsilia GM, Boscaino A, La Mura A, Ceriello A, De Ritis R: Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? Int J Surg Pathol; 2010 Dec;18(6):537-9
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  • Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45.
  • The tumor cells of intramural small intestinal mass were positive for S-100 protein and GFAP and negative for CD117, CD34 and desmin.
  • [MeSH-major] Angiomyolipoma / pathology. Jejunal Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19282295.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Yamaguchi J, Ohtani H, Nakamura K, Shimokawa I, Kanematsu T: Prognostic impact of marginal adipose tissue invasion in ductal carcinoma of the breast. Am J Clin Pathol; 2008 Sep;130(3):382-8
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  • [Title] Prognostic impact of marginal adipose tissue invasion in ductal carcinoma of the breast.
  • This study aimed to investigate whether adipose tissue invasion (ATI) of cancer cells at the tumor margin influenced lymph node status and prognosis in patients with invasive ductal carcinoma of the breast.
  • Patients with ATI had a poorer prognosis than patients without ATI (10-year disease-free survival, 76% and 94%, respectively; P=.0323).
  • In addition, patients without ATI or LVI had neither lymph node metastasis (n=52) nor recurrent disease (n=53).
  • ATI is one of the biologic indicators of tumor aggressiveness.
  • [MeSH-major] Adipose Tissue / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis / pathology. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 18701411.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Molyneux G, Regan J, Smalley MJ: Mammary stem cells and breast cancer. Cell Mol Life Sci; 2007 Dec;64(24):3248-60
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  • It is thought that stem cells drive mammary gland development during puberty and are responsible for tissue maintenance as well as the major growth and remodelling that occurs with every pregnancy.
  • The use of sophisticated cell separation procedures has facilitated the prospective isolation of mammary epithelial stem and differentiated cell subpopulations from the mouse mammary gland, while studies of primary human breast cancers have described sub-populations of tumourigenic cells capable of initiating tumour growth in immuno-compromised mice.
  • These potential tumour 'stem cells' constitute an important therapeutic target population with respect to cancer therapy, as these are likely to be the cells which maintain tumour growth.
  • Understanding the origin of these cells, their relationship to breast cancer subtypes, and how and why they differ from normal breast stem cells will lead to a revolution in tumour understanding, treatment and prevention. (Part of a Multi-author Review).
  • [MeSH-major] Breast Neoplasms / pathology. Mammary Glands, Human / cytology. Stem Cells / physiology
  • [MeSH-minor] Adipose Tissue / transplantation. Animals. Female. Humans. Mammary Glands, Animal / cytology. Mammary Glands, Animal / growth & development. Mammary Glands, Animal / physiology. Mice. Models, Biological. Neoplastic Stem Cells / classification. Neoplastic Stem Cells / pathology. Neoplastic Stem Cells / physiology

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  • (PMID = 17955177.001).
  • [ISSN] 1420-682X
  • [Journal-full-title] Cellular and molecular life sciences : CMLS
  • [ISO-abbreviation] Cell. Mol. Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 104
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48. Cobanoglu U, Yaris N, Cay A: Adrenal myelolipoma in a child. Pediatr Surg Int; 2005 Jun;21(6):500-2
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  • Histological examination of the adrenal mass revealed a proliferation of mature adipose tissue with bone marrow-like hematopoietic elements.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Myelolipoma / surgery

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  • [Cites] Arch Pathol Lab Med. 1995 Mar;119(3):283-5 [7887786.001]
  • [Cites] Am J Pathol. 1950 Mar;26(2):211-33 [15406252.001]
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  • (PMID = 15809845.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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49. Grossmann ME, Ray A, Nkhata KJ, Malakhov DA, Rogozina OP, Dogan S, Cleary MP: Obesity and breast cancer: status of leptin and adiponectin in pathological processes. Cancer Metastasis Rev; 2010 Dec;29(4):641-53
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  • Furthermore, obesity may adversely affect tumor progression, metastasis, and overall prognosis in both pre- and postmenopausal women with breast cancer.
  • Recently, adipose tissue and its associated cytokine-like proteins, adipokines, particularly leptin and adiponectin, have been investigated as mediators for the association of obesity with breast cancer.
  • [MeSH-major] Adiponectin / metabolism. Breast Neoplasms / metabolism. Leptin / metabolism. Obesity / metabolism
  • [MeSH-minor] Animals. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. Disease Progression. Female. Humans

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  • (PMID = 20821253.001).
  • [ISSN] 1573-7233
  • [Journal-full-title] Cancer metastasis reviews
  • [ISO-abbreviation] Cancer Metastasis Rev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA101858
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Leptin
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50. Wolff MS, Anderson HA, Britton JA, Rothman N: Pharmacokinetic variability and modern epidemiology--the example of dichlorodiphenyltrichloroethane, body mass index, and birth cohort. Cancer Epidemiol Biomarkers Prev; 2007 Oct;16(10):1925-30
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  • [MeSH-major] Body Mass Index. Carcinogens, Environmental / pharmacokinetics. DDT / pharmacokinetics. Neoplasms / chemically induced. Pesticides / pharmacokinetics
  • [MeSH-minor] Adipose Tissue / metabolism. Cohort Studies. Cross-Sectional Studies. Dichlorodiphenyl Dichloroethylene / pharmacokinetics. Dichlorodiphenyl Dichloroethylene / toxicity. Environmental Monitoring. Epidemiological Monitoring. Half-Life. Humans. Hydrocarbons, Halogenated / pharmacokinetics. Hydrocarbons, Halogenated / toxicity. Metabolic Clearance Rate. Obesity / blood. Pesticide Residues / pharmacokinetics. Pesticide Residues / toxicity. Polychlorinated Biphenyls / pharmacokinetics. Polychlorinated Biphenyls / toxicity. Risk Assessment. Risk Factors. Statistics as Topic

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  • (PMID = 17932339.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA665572; United States / NCI NIH HHS / CA / CA93447; United States / NIEHS NIH HHS / ES / ES0102771; United States / NIEHS NIH HHS / ES / ES012771; United States / NIEHS NIH HHS / ES / ES09584
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens, Environmental; 0 / Hydrocarbons, Halogenated; 0 / Pesticide Residues; 0 / Pesticides; 4M7FS82U08 / Dichlorodiphenyl Dichloroethylene; CIW5S16655 / DDT; DFC2HB4I0K / Polychlorinated Biphenyls
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51. Cox A, Offman SL, Merrimen JL, Kew A, Norman RW: Bilateral renal sinus myelolipomas. Can Urol Assoc J; 2010 Dec;4(6):E164-8
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  • Adrenal myelolipomas are benign neoplasms consisting of hematopoietic cellular elements and adipose tissue.
  • They are difficult to diagnose on imaging alone when arising in this location and biopsies may not yield a definitive answer.
  • Management options include both conservative and surgical approaches depending upon the certainty of the diagnosis, progression of the patient's symptoms and evidence of growth.

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  • (PMID = 21749813.001).
  • [ISSN] 1920-1214
  • [Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • [ISO-abbreviation] Can Urol Assoc J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3038377
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52. Sinna R, Delay E, Garson S, Delaporte T, Toussoun G: Breast fat grafting (lipomodelling) after extended latissimus dorsi flap breast reconstruction: a preliminary report of 200 consecutive cases. J Plast Reconstr Aesthet Surg; 2010 Nov;63(11):1769-77
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  • We present the results of a retrospective report of the first 200 consecutive patients treated at our institution from 1999 to 2003.
  • METHODS: We identified specific requirements of the patients, and collected information on the surgical techniques used and the volumes of fat tissue injected.
  • We analysed and compared the results of a total of 244 lipomodelling sessions.
  • [MeSH-major] Adipose Tissue / transplantation. Mammaplasty / methods. Muscle, Skeletal / transplantation. Surgical Flaps
  • [MeSH-minor] Adolescent. Adult. Aged. Breast Neoplasms / surgery. Female. Follow-Up Studies. Humans. Mastectomy. Middle Aged. Reoperation. Retrospective Studies. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20079699.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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53. Kolenc D, Zarković K, Jednacak H, Ozretić D, Habek M: Sellar angiolipomas: two case reports and a review of the literature. J Neurooncol; 2008 Aug;89(1):109-12
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  • Angiolipomas are mesenchymal hamartomas composed of abnormal blood vessels and mature adipose tissue, most commonly found in the subcutaneous tissue of the extremities.
  • Sellar angiolipomas should be considered in the differential diagnosis of pituitary lesions due to the potential catastrophic bleeding during surgery.
  • Preoperative diagnosis is very difficult; however, some MRI characteristics can help make an accurate diagnosis.
  • [MeSH-major] Adipose Tissue / pathology. Angiolipoma / pathology. Blood Vessels / pathology. Pituitary Gland / pathology. Pituitary Neoplasms / pathology
  • [MeSH-minor] Antigens, CD34 / analysis. Antigens, CD34 / metabolism. Factor VIII / analysis. Factor VIII / metabolism. Female. Humans. Magnetic Resonance Imaging / methods. Magnetic Resonance Imaging / standards. Male. Middle Aged. Neoplasm, Residual. Postoperative Hemorrhage / pathology. Postoperative Hemorrhage / physiopathology. Postoperative Hemorrhage / prevention & control. Preoperative Care. Radiosurgery. Sella Turcica / pathology. Sella Turcica / physiopathology

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  • (PMID = 18480966.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 9001-27-8 / Factor VIII
  • [Number-of-references] 8
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54. McLaughlin RA, Scolaro L, Robbins P, Hamza S, Saunders C, Sampson DD: Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer. Cancer Res; 2010 Apr 1;70(7):2579-84
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  • Histologic assessment is the gold standard technique for the identification of metastatic involvement of lymph nodes in malignant disease, but can only be performed ex vivo and often results in the unnecessary excision of healthy lymph nodes, leading to complications such as lymphedema.
  • Optical coherence tomography (OCT) is a high-resolution, near-IR imaging modality capable of visualizing microscopic features within tissue.
  • OCT has the potential to provide in vivo assessment of tissue involvement by cancer.
  • In this morphologic study, we show the capability of OCT to image nodal microarchitecture through an assessment of fresh, unstained ex vivo lymph node samples.
  • Through accurate correlation with the histologic gold standard, OCT is shown to enable differentiation of lymph node tissue from surrounding adipose tissue, reveal nodal structures such as germinal centers and intranodal vessels, and show both diffuse and well circumscribed patterns of metastatic node involvement.
  • [MeSH-major] Lymph Nodes / pathology. Neoplasms / pathology. Tomography, Optical Coherence / methods
  • [MeSH-minor] Breast Neoplasms / pathology. Breast Neoplasms / ultrastructure. Carcinoma, Ductal, Breast / pathology. Carcinoma, Ductal, Breast / ultrastructure. Female. Humans. Lymphatic Metastasis. Neoplasm Staging / methods

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  • (PMID = 20233873.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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55. Inui A: [Recent development in research and management of cancer anorexia-cachexia syndrome]. Gan To Kagaku Ryoho; 2005 Jun;32(6):743-9
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  • Associated with anorexia, fat and muscle tissue wasting, psychological distress, and a lower quality of life, cachexia arises from a complex interaction between the cancer and the host.
  • Cytokines play a pivotal role in long-term inhibition of feeding by mimicking the hypothalamic effect of excessive negative feedback signaling from leptin, a hormone secreted by adipose tissue, which is an integral component of the homeostatic loop of body weight regulation.
  • These include antiserotonergic drugs, gastroprokinetic agents, branched-chain amino acids, eicosapentanoic acid, cannabinoids, melatonin, and thalidomide-all of which act on the feeding-regulatory circuitry to increase appetite and inhibit tumor-derived catabolic factors to antagonize tissue wasting and/or host cytokine release.
  • Evaluations of relaxation, hypnosis, and short-term group psychotherapy have suggested some benefit with regard to anorexia and fatigue, although the population most likely to benefit from these interventions has not yet been determined.
  • [MeSH-major] Anorexia / etiology. Body Weight / physiology. Cachexia / etiology. Leptin / physiology. Neoplasms / complications

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  • (PMID = 15984510.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Leptin
  • [Number-of-references] 32
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56. Sedjo RL, Byers T, Levin TR, Haffner SM, Saad MF, Tooze JA, D'Agostino RB Jr: Change in body size and the risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev; 2007 Mar;16(3):526-31
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  • Adiposity has been recognized as a risk factor for colorectal adenoma, but the influence of weight gain, adipose tissue distribution, and possible differences between ethnic/racial and gender groups remains unanswered.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Body Size. Colorectal Neoplasms / epidemiology

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  • (PMID = 17372248.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R01CA88007; United States / NIDDK NIH HHS / DK / DK07658; United States / NCI NIH HHS / CA / R01 CA88008
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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57. Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss JM: Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat; 2010 Jan;119(2):367-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients.
  • Adiopcyte fatty acid binding-protein(A-FABP) is another protein found in adipose tissue;therefore, we investigated the association of A-FABP with the occurrence and prognosis of breast cancer.
  • Serum levels ofA-FABP, leptin, and adiponectin were measured, and their relationship to body-mass-index (BMI), breast cancer, and tumor characteristics were analyzed; logistic regression model was adjusted to age, BMI, menopausal status, use of Hormone Replacement Therapy (HRT), and family history of breast cancer.
  • Independent of obesity, the serum A-FABP levels were significantly higher in breast cancer patients (34.65 ng/ml) than in healthy controls(24.47 ng/ml), P.0001; the odds ratio (1.038, P.05,95% confidence interval 1.001-1.72) showed a significant association of A-FABP with breast cancer risk.
  • Concerning tumor characteristics,A-FABP was positively connected with tumor size (T C 2 cm, P.05) and nodal-status (P.05).Our study reveals that high A-FABP serum levels are associated with obesity, breast cancer risk, and adverse tumor characteristics.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / etiology. Fatty Acid-Binding Proteins / blood. Obesity / complications
  • [MeSH-minor] Adiponectin / blood. Adult. Aged. Body Mass Index. Case-Control Studies. Female. Humans. Leptin / blood. Logistic Models. Middle Aged. Neoplasm Staging. Odds Ratio. Postmenopause. Predictive Value of Tests. Premenopause. Risk Assessment. Risk Factors. Treatment Outcome. Up-Regulation

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  • (PMID = 19842034.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / ADIPOQ protein, human; 0 / Adiponectin; 0 / Biomarkers, Tumor; 0 / FABP4 protein, human; 0 / Fatty Acid-Binding Proteins; 0 / Leptin
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58. Maiorano E, Capodiferro S, Fanelli B, Calabrese L, Napoli A, Favia G: Hamartomatous angiolipoma of the parotid gland (sialoangiolipoma). Head Neck Pathol; 2008 Mar;2(1):36-40
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  • Mesenchymal tumors of the salivary glands are rare and mostly localized to the parotid gland.
  • We report on the clinico-pathological features of a distinct parotid tumor occurred in a newborn, showing glandular structures admixed with mature lipocytes and blood vessels in variable proportions.
  • The morphological features of the lesion reported herein recapitulate those of sialolipoma but also include the presence of a prominent vascular component intimately admixed with both the glandular and the adipose tissues.
  • [MeSH-major] Angiolipoma / pathology. Hamartoma / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Child, Preschool. Female. Humans. Infant, Newborn

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  • (PMID = 20614340.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807606
  • [Keywords] NOTNLM ; Angiolipoma / Lipoma / Salivary gland neoplasms / Sialolipoma / Soft tissue tumors
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59. Erkiliç S, Koçer NE, Mumbuç S, Kanlikama M: Nasal angiomyolipoma. Acta Otolaryngol; 2005 Apr;125(4):446-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiomyolipomas (AMLs) are hamartomatous lesions containing smooth muscle, vasculature and mature adipose tissue.
  • Histopathologic examination revealed that the lesion was composed of smooth muscle bundles, mature adipose tissue and blood vessels of different sizes.
  • In conclusion, although nasal AML is a rare lesion, it should be considered in the differential diagnosis of polypoid nasal masses, especially when the mass occurs unilaterally.
  • [MeSH-major] Angiomyolipoma / diagnosis. Nasal Polyps / diagnosis. Nose Neoplasms / diagnosis
  • [MeSH-minor] Actins / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Endoscopy. Humans. Male. Middle Aged. Muscle, Smooth / pathology. Nasal Obstruction / diagnosis. Nasal Obstruction / pathology. Nasal Obstruction / surgery

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  • (PMID = 15823821.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor
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60. Dong J, Tsai-Morris CH, Dufau ML: A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. J Biol Chem; 2006 Jul 7;281(27):18825-36
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  • Prolactin exerts diverse functions in target tissues through its membrane receptors, and is a potent mitogen in normal and neoplastic breast cells.
  • Estradiol produced in breast stroma and adipose tissue, which are major sources of estrogen in post-menopausal women, could up-regulate hPRLR gene expression and stimulate breast tumor growth.
  • [MeSH-minor] Breast Neoplasms / genetics. Breast Neoplasms / metabolism. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Estradiol / metabolism. Estradiol / pharmacology. Female. Histone Acetyltransferases / genetics. Histone Acetyltransferases / metabolism. Humans. Models, Molecular. Nuclear Receptor Coactivator 1. Protein Binding. Sp1 Transcription Factor / genetics. Sp1 Transcription Factor / metabolism. Sp3 Transcription Factor / genetics. Sp3 Transcription Factor / metabolism. Transcription Factors / genetics. Transcription Factors / metabolism. Transcription, Genetic. Transcriptional Activation / drug effects. p300-CBP Transcription Factors

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  • (PMID = 16651265.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Estrogen Receptor alpha; 0 / Receptors, Prolactin; 0 / Sp1 Transcription Factor; 0 / Transcription Factors; 148710-94-5 / Sp3 Transcription Factor; 4TI98Z838E / Estradiol; EC 2.3.1.48 / Histone Acetyltransferases; EC 2.3.1.48 / NCOA1 protein, human; EC 2.3.1.48 / Nuclear Receptor Coactivator 1; EC 2.3.1.48 / p300-CBP Transcription Factors; EC 2.3.1.48 / p300-CBP-associated factor
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61. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • We present a rare atypical lipomatous tumour with spindle cell features (synonym: well-differentiated spindle cell liposarcoma) arising on the left palm of a 54-year-old male patient.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • However, focally, atypia of adipocytic and stromal cells as well as scattered lipoblasts were noted, and immunohistochemical stainings showed focal overexpression of MDM 2 and CDK4.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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62. Abel TW, Curtis M, Lin DD, Burger PC, Cummings TJ: Complex choristoma of the gyrus rectus: a distinct clinicopathologic entity? Am J Surg Pathol; 2006 May;30(5):625-9
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  • Smooth muscle actin-immunoreactive myoepithelial cells were present in the basal layer, indicating glandular differentiation.
  • In some areas, the epithelial structures were separated by reactive glial tissue resembling pilocytic astrocytoma, with prominent, piloid processes, Rosenthal fibers, and gemistocytic astrocytes.
  • Tissue resembling mature adipose was present focally.
  • Follow-up interval of up to 2 years showed no evidence of recurrent tumor.
  • [MeSH-minor] Adult. Brain Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Neural Crest. Seizures / etiology

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  • (PMID = 16699317.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Zhao M, Dumur CI, Holt SE, Beckman MJ, Elmore LW: Multipotent adipose stromal cells and breast cancer development: Think globally, act locally. Mol Carcinog; 2010 Nov;49(11):923-7
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  • [Title] Multipotent adipose stromal cells and breast cancer development: Think globally, act locally.
  • It has long been appreciated that stromal cells within the breast tumor microenvironment contribute to mammary carcinogenesis.
  • However, to date, very little is known regarding the role of local adipose-derived stromal cells (ASCs) in the development of breast cancer.

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  • [Copyright] © 2010 Wiley-Liss, Inc.
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  • (PMID = 20842668.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA016059-21; United States / NCI NIH HHS / CA / P30CA16059; United States / NCI NIH HHS / CA / K01 CA105050-05; United States / NCI NIH HHS / CA / KO1 CA105050-01A131; United States / NINDS NIH HHS / NS / P30 NS047463; United States / NCI NIH HHS / CA / P30 CA016059-21; United States / NCI NIH HHS / CA / K01 CA105050; United States / NINDS NIH HHS / NS / P30 NS047463-09; United States / NCI NIH HHS / CA / P30 CA016059; United States / NINDS NIH HHS / NS / 5P30NS047463
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS347994; NLM/ PMC3276248
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64. Percik R, Stumvoll M: Obesity and cancer. Exp Clin Endocrinol Diabetes; 2009 Nov;117(10):563-6
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  • Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and "secondary" associations via "precursor" condition such as gallstones.
  • [MeSH-major] Neoplasms / epidemiology. Obesity / epidemiology

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  • [Copyright] Copyright J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 19924603.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Insulin; 0 / Leptin
  • [Number-of-references] 35
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65. Zhang Q, Zhu QL, Jiang YX, Zhang B, Dai Q, Lou HY: [Sonographic and computed tomography features of hepatic angiomyolipoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2010 Oct;32(5):561-4
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  • The CT findings included adipose density (n=3), soft tissue density (n=3), and mixed density (n=6).
  • The sonographic and CT findings were correlated with the composition and distribution of fat, vessels, and smooth muscle tissue.
  • CONCLUSIONS: Fatty tissues within HAML shows typical imaging findings.
  • The ultrasonographic and CT have their own advantages in detecting the fatty tissue inside HAML, and therefore a combination of these two techniques may increase the diagnostic accuracy of HAML.
  • [MeSH-major] Angiomyolipoma / radiography. Angiomyolipoma / ultrasonography. Liver Neoplasms / radiography. Liver Neoplasms / ultrasonography

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  • (PMID = 21050562.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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66. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage Studies). Natl Toxicol Program Tech Rep Ser; 2006 Apr;(521):4-232
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  • Due to their lipophilicity and persistence, once internalized, they accumulate in body tissue, mainly adipose, resulting in chronic lifetime human exposure.
  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • TCDD is not manufactured commercially other than for scientific research purposes.
  • DETERMINATIONS OF TCDD CONCENTRATIONS IN TISSUES: The tissue disposition of TCDD was analyzed in the liver, lung, fat, and blood of all animals in each group at the 14-, 31-, and 53-week interim evaluations and in 10 animals per group at the end of the 2-year study (105 weeks).
  • The highest concentrations of TCDD were observed in the liver, followed by fat tissue.
  • Liver and fat tissue concentrations of TCDD increased with increasing doses of TCDD.
  • In liver tissue from the stop-exposure group, TCDD concentrations were slightly higher than those observed in the 3 ng/kg group.
  • At 2 years, there was a significant increase in toxic hepatopathy characterized by increased incidences of numerous nonneoplastic liver lesions including hepatocyte hypertrophy, multinucleated hepatocytes, altered hepatocellular foci, inflammation, pigmentation, diffuse fatty change, necrosis, portal fibrosis, oval cell hyperplasia, bile duct hyperplasia, bile duct cysts, cholangiofibrosis, and nodular hyperplasia At 2 years, the incidence of hepatocellular adenoma was significantly increased in the 100 ng/kg core study group.
  • [MeSH-minor] Animals. Body Weight / drug effects. Carcinogenicity Tests. Female. Mice. Neoplasms, Experimental / chemically induced. Organ Size / drug effects. Rats. Rats, Sprague-Dawley

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  • (PMID = 16835633.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; DO80M48B6O / Tetrachlorodibenzodioxin
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67. Cecoli F, Andraghetti G, Ghiara C, Briatore L, Cavallero D, Mussap M, Minuto F, Giusti M: Absence of thyrotropin-induced increase in leptin levels in patients with history of differentiated thyroid carcinoma undergoing recombinant human thyrotropin testing. J Endocrinol Invest; 2008 Oct;31(10):888-92
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  • Leptin is the main protein secreted by adipose tissue.
  • [MeSH-major] Carcinoma / physiopathology. Leptin / blood. Thyroid Neoplasms / physiopathology. Thyrotropin

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  • (PMID = 19092294.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Leptin; 0 / Recombinant Proteins; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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68. François P, Zemmoura I, Fouquet AM, Jan M, Velut S: Lateral sellar angiolipoma: a tumor illustrative of the extradural compartment of the neural axis. J Neurosurg; 2010 Nov;113(5):1053-8
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  • [Title] Lateral sellar angiolipoma: a tumor illustrative of the extradural compartment of the neural axis.
  • Angiolipomas are rare tumors of the CNS that most frequently develop in the orbit, the cavernous space, and the epidural space of the spine.
  • The authors report the case of a patient who presented with an angiolipoma of the cavernous space.
  • Using data from the published literature and an experimental anatomical approach, they demonstrate that the cavernous space contains adipose tissue.
  • Consequently, they suggest that angiolipomas constitute a characteristic tumor illustrating the interperiosteo-dural concept.
  • The authors report the clinical, radiological, and histological data of a patient who presented with a tumor of the cavernous space.
  • This case report corroborates previously published clinical data and shows that the tumor was a hamartoma comprising mature fat cells associated with vascular proliferation.
  • The tumor developed in the cavernous space, which is an interperiosteo-dural space extending from the sphenoid periosteum (osteoperiosteal layer) to the superior and lateral walls of the cavernous space (encephalic layer).
  • It contains fat tissue that is abundant at the level of the orbit and the epidural spinal space and sparser at the level of the cavernous spaces, as was shown in our anatomical study.
  • The authors suggest that angiolipomas represent a characteristic tumor that illustrates the interperiosteo-dural concept because they essentially develop in the fat tissue contained in these spaces.
  • [MeSH-major] Angiolipoma / pathology. Brain Neoplasms / pathology. Cavernous Sinus / pathology

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  • (PMID = 20151784.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Zanelli M, Cortecchia S, Righi E, Caprara L, De Lillo M, Costa F, Galanti G, Bondi A: Epithelioid angiomyolipoma of the kidney: case report. Pathologica; 2008 Jun;100(3):202-5
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  • Renal angiomyolipoma is a benign tumour histologically characterized by a mixture of adipose tissue, smooth muscle cells and thick walled blood vessels.
  • Positivity for HMB45, Melan A, CD68 and CD117 are useful for diagnosis.
  • Herein, we report the clinicopathologic and immunohistochemical features of a renal tumour composed of large epithelioid mononucleated or multinucleated cells with abundant acidophilic cytoplasm and prominent nucleoli.
  • Despite the morphologic resemblance of this tumour to renal cell carcinoma, its phenotype (HMB45, Melan A and CD68 positivity and keratin negativity) parallels the phenotypic profile of angiomyolipoma.
  • [MeSH-major] Angiomyolipoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18841830.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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70. Tamura E, Fukuda H, Tabata Y, Nishimura M: Use of the buccal fat [corrected] pad for vocal cord augmentation. Acta Otolaryngol; 2008 Feb;128(2):219-24
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  • Adipose tissues used have been harvested mostly from the lower abdomen.
  • [MeSH-major] Adipose Tissue / transplantation. Vocal Cord Paralysis / rehabilitation. Voice Disorders / rehabilitation
  • [MeSH-minor] Adolescent. Adult. Aged. Cheek. Female. Humans. Injections. Laryngoscopy. Male. Middle Aged. Otorhinolaryngologic Neoplasms / surgery. Postoperative Complications / etiology. Postoperative Complications / rehabilitation. Stroboscopy. Tissue and Organ Harvesting

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  • (PMID = 17882561.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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71. Russell ST, Tisdale MJ: The role of glucocorticoids in the induction of zinc-alpha2-glycoprotein expression in adipose tissue in cancer cachexia. Br J Cancer; 2005 Mar 14;92(5):876-81
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  • [Title] The role of glucocorticoids in the induction of zinc-alpha2-glycoprotein expression in adipose tissue in cancer cachexia.
  • Loss of adipose tissue in cancer cachexia in mice bearing the MAC16 tumour arises from an increased lipid mobilisation through increased expression of zinc-alpha2-glycoprotein (ZAG) in white (WAT) and brown (BAT) adipose tissue.
  • In mice bearing the MAC16 tumour, serum cortisol concentrations increased in parallel with weight loss, and the glucocorticoid receptor antagonist RU38486 (25 mg kg(-1)) attenuated both the loss of body weight and ZAG expression in WAT.
  • This suggests that glucocorticoids stimulate lipolysis through an increase in ZAG expression, and that they are responsible for the increase in ZAG expression seen in adipose tissue of cachectic mice.
  • [MeSH-major] Adipocytes / physiology. Adipose Tissue / metabolism. Cachexia / physiopathology. Glucocorticoids / pharmacology. Lipolysis / drug effects. Neoplasms, Experimental / physiopathology. Seminal Plasma Proteins / genetics
  • [MeSH-minor] 3T3 Cells. Adipose Tissue, Brown / drug effects. Adipose Tissue, Brown / metabolism. Animals. Hydrocortisone / blood. Mice. Mice, Inbred Strains

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  • (PMID = 15714206.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glucocorticoids; 0 / Seminal Plasma Proteins; 0 / Zn-alpha-2-glycoprotein; WI4X0X7BPJ / Hydrocortisone
  • [Other-IDs] NLM/ PMC2361908
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72. Ahmed B, Estey E, Manning J, David C, Keating MJ, Kantarjian H, Tsimberidou AM: Anaplastic large cell lymphoma with involvement of the pancreas presenting as panniculitis in a patient with a history of acute myeloid leukemia--case report and review of the literature. Haematologica; 2006 Dec;91(12 Suppl):ECR55
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  • An autopsy of the pancreas revealed clusters of large, atypical cells, which morphologically and immunophenotypically were consistent with CD30 positive, ALK-negative anaplastic large cell lymphoma (ALCL) of T-cell lineage and multifocal fat necrosis (panniculitis) in the peripancreatic adipose tissue.
  • [MeSH-major] Leukemia, Myeloid / drug therapy. Lymphoma, Large-Cell, Anaplastic / diagnosis. Neoplasms, Second Primary / diagnosis. Pancreas / pathology. Panniculitis / etiology
  • [MeSH-minor] Acute Disease. Aged. Fatal Outcome. Humans. Male. Neoplasm Proteins / analysis. Respiratory Insufficiency / etiology


73. Prantl L, Muehlberg F, Navone NM, Song YH, Vykoukal J, Logothetis CJ, Alt EU: Adipose tissue-derived stem cells promote prostate tumor growth. Prostate; 2010 Nov 1;70(15):1709-15
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  • [Title] Adipose tissue-derived stem cells promote prostate tumor growth.
  • BACKGROUND: Recent evidence indicates that cancer stem cells play an important role in tumor initiation and maintenance.
  • Additionally, the effect of tissue-resident stem cells located in the surrounding healthy tissue on tumor progression has been demonstrated.
  • While most knowledge has been derived from studies of breast cancer cells, little is known regarding the influence of tissue resident stem cells on the tumor biology of prostate cancer.
  • (1) subcutaneous injection of 10(6) MDA PCa 118b human prostate cancer cells into the upper back or (2) subcutaneous injection of 10(6) MDA PCa 118b cells mixed directly with 10(5) GFP-labeled human adipose tissue-derived stem cells (hASCs).
  • Tumor growth and volumes over the ensuing 3 weeks were assessed using calipers and micro-computed tomography.
  • Immunohistochemistry was performed to identify engrafted hASCs in tumor sections.
  • RESULTS: At 3 weeks after injection, the mean tumor volume in the MDA PCa 118b/hASC co-injection group (1019.95 ± 73.49 mm(3)) was significantly higher than that in the MDA PCa 118b-only group (308.70 ± 21.06 mm(3)).
  • Engrafted hASCs exhibited the nuclear marker of proliferation Ki67 and expressed markers for endothelial differentiation, indicating their engraftment in tumor vessels.
  • CONCLUSION: Our study revealed for the first time that ASCs subcutaneously co-injected with prostate cancer cells engraft and promote tumor progression.
  • Further evaluation of the cross-talk between tumor and local tissue-resident stem cells may lead to new strategies for prostate cancer therapy.
  • [MeSH-major] Adipose Tissue / cytology. Neoplastic Stem Cells / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Animals. Disease Models, Animal. Flow Cytometry. Immunophenotyping. Male. Mice. Mice, Nude. Neoplasm Transplantation / methods. Random Allocation. Tomography, X-Ray Computed

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  • (PMID = 20564322.001).
  • [ISSN] 1097-0045
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS612155; NLM/ PMC4977846
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74. Damstra RJ, Voesten HG, Klinkert P, Brorson H: Circumferential suction-assisted lipectomy for lymphoedema after surgery for breast cancer. Br J Surg; 2009 Aug;96(8):859-64
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  • Although most women can be treated by non-operative means with satisfying results, end-stage lymphoedema is often non-responsive to compression, where hypertrophy of adipose tissue limits the outcome value of compression or massage.
  • The total aspirate volume was 2124 ml with 93 per cent aspirate adipose tissue content.
  • [MeSH-major] Breast Neoplasms / surgery. Lipectomy / methods. Lymphedema / surgery. Postoperative Complications / surgery
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Aged. Arm. Female. Humans. Intermittent Pneumatic Compression Devices. Length of Stay. Middle Aged. Postoperative Care. Prospective Studies

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  • [Copyright] Copyright 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 19591161.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Zhou YM, Li B, Xu F, Wang B, Li DQ, Zhang XF, Liu P, Yang JM: Clinical features of hepatic angiomyolipoma. Hepatobiliary Pancreat Dis Int; 2008 Jun;7(3):284-7
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  • BACKGROUND: Hepatic angiomyolipoma (HAML) is a rare hepatic mesenchymal tumor.
  • Pre-operative diagnosis was made in only 3 patients.
  • Pathological study showed that the tumor was composed of adipose tissue, smooth muscle and blood vessels in different proportions.
  • HMB-45 immunohistochemical staining was positive in all tumors.
  • Except for one patient who died 14 months after operation because of recurrent disease, no tumor recurrence was observed in the remaining 25 patients during a 2-3 years follow-up.
  • CONCLUSIONS: Pre-operative diagnosis of HAML is difficult.
  • [MeSH-major] Angiomyolipoma / pathology. Hepatectomy / methods. Liver Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 18522883.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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76. Zilli T, Chagnon M, Van Nguyen T, Bahary JP, Guay JP, Dufresne A, Taussky D: Influence of abdominal adiposity, waist circumference, and body mass index on clinical and pathologic findings in patients treated with radiotherapy for localized prostate cancer. Cancer; 2010 Dec 15;116(24):5650-8
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  • The relation among abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), waist circumference (WC), and BMI was compared with clinical and pathologic findings in patients treated with radiotherapy for localized PC.
  • Younger age at diagnosis was significantly correlated with higher SAT and BMI, whereas increased prostate size was found in patients with higher BMI, WC, SAT, and VAT.
  • [MeSH-major] Abdominal Fat. Body Mass Index. Obesity / pathology. Prostatic Neoplasms / pathology. Prostatic Neoplasms / radiography. Waist Circumference
  • [MeSH-minor] Aged. Comorbidity. Humans. Male. Middle Aged. Neoplasms, Second Primary / epidemiology. Subcutaneous Fat / pathology


77. Guven M, Suoglu Y, Kiyak E, Demir D: Autologous fat augmentation for voice and swallow improvement after cordectomy. ORL J Otorhinolaryngol Relat Spec; 2006;68(3):164-9
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  • In most patients, newly formed neocord tissue preserves glottic functions, but in some patients an important glottic gap leading to glottic insufficiency may occur.
  • In our study, 11 patients who had serious glottic insufficiency after endoscopic laser and laryngofissure cordectomy were treated with autologous fat injection (AFI) into the neocord tissue for voice and swallowing rehabilitation.
  • One patient did not attend the first control visit and was excluded from the study.
  • [MeSH-major] Adipose Tissue / transplantation. Carcinoma, Squamous Cell / surgery. Deglutition Disorders / surgery. Laryngeal Neoplasms / surgery. Vocal Cords / surgery. Voice Disorders / surgery

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  • [Copyright] Copyright 2006 S. Karger AG, Basel
  • (PMID = 16465071.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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78. Bershteĭn LM, Tsyrlina EV, Kovalevskiĭ AIu, Vasil'ev DA, Poroshina TE, Kovalenko IG, Kotov AV, Pozharisskiĭ KM: [Endocrine-genotoxic switchings as promoter of main noninfectious diseases]. Vestn Ross Akad Med Nauk; 2008;(1):12-8
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  • The increase in the genotoxic effect of estrogens, isolated or combined with the weakening of the hormonal effect, can worsen the clinical course of MNID (including malignant tumors of hormone-dependent tissues).
  • Both approaches may be divided into several groups with different points of application, whereas their ultimate goal is optimal balance between hormonal and DNA-damaging effects of estrogens, glucose, and adipose tissue-associated factors.

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  • (PMID = 18318150.001).
  • [ISSN] 0869-6047
  • [Journal-full-title] Vestnik Rossiiskoi akademii meditsinskikh nauk
  • [ISO-abbreviation] Vestn. Akad. Med. Nauk SSSR
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Estrogens; IY9XDZ35W2 / Glucose
  • [Number-of-references] 53
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79. Nishihara K, Nozoe E, Hirayama Y, Miyawaki A, Semba I, Nakamura N: A case of small cell carcinoma in the buccal region. Int J Oral Maxillofac Surg; 2009 Sep;38(9):1000-3
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  • Small cell carcinoma (SCC) in the head and neck region is an extremely rare high-grade malignant tumor.
  • Histopathological examination revealed invasive growth of an SCC into the musculo-adipose tissue.
  • Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3), neuron-specific enolase (NSE) and CD56, but negative for cytokeratin 20.
  • The patient received chemotherapy and radiotherapy, which resulted in marked regression of the tumor.
  • The serum levels of NSE and pro-gastrin-releasing peptide (pro-GRP) increased and multiple metastases of the tumor occurred 1 month after surgery.
  • SCCs tend to exhibit aggressive invasion and metastasis so chemotherapy for the whole body is recommended to prevent dissemination of the tumor cells.
  • Serum levels of NSE and pro-GRP are considered to be useful tumor markers for understanding the status of the tumor and the clinical symptoms.
  • [MeSH-major] Carcinoma, Small Cell / pathology. Cheek / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / blood. Combined Modality Therapy. Fatal Outcome. Humans. Male. Peptide Fragments / blood. Phosphopyruvate Hydratase / blood. Recombinant Proteins / blood

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  • (PMID = 19464148.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptide Fragments; 0 / Recombinant Proteins; 0 / pro-gastrin-releasing peptide (31-98); EC 4.2.1.11 / Phosphopyruvate Hydratase
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80. Yao M, Tabuchi H, Nagashima Y, Baba M, Nakaigawa N, Ishiguro H, Hamada K, Inayama Y, Kishida T, Hattori K, Yamada-Okabe H, Kubota Y: Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J Pathol; 2005 Feb;205(3):377-87
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  • [Title] Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma.
  • The gene expression profiles of 33 renal cell carcinomas (RCCs) and nine normal kidney samples were examined using high-density oligonucleotide microarrays in an attempt to identify biomolecular markers for the diagnosis of tumour subtypes and also for prediction of prognosis.
  • Hierarchical clustering demonstrated that clear-cell RCC, chromophobe RCC, and normal kidney tissue showed distinctive gene expression profiles.
  • The mean expression levels of 149 of 12 500 genes were more than three times higher in clear-cell RCC than in chromophobe RCC and normal kidney tissue.
  • Among the genes whose expression was upregulated in clear-cell RCC, adipose differentiation-related protein (ADFP) and nicotinamide N-methyltransferase (NNMT) were selected for further analysis.
  • Consistent with the results of the microarray, increased levels of ADFP and NNMT mRNA were found more frequently in clear-cell RCCs than in other non-clear-cell tumour subtypes using real-time quantitative PCR.
  • Immunohistochemistry for ADFP showed strong and unique tumour cell staining patterns in the majority of clear-cell RCCs.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Cluster Analysis. Female. Gene Expression Profiling / methods. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis / methods. Prognosis. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Survival Analysis. Up-Regulation


81. Brown JF Jr, Mayes BA, Silkworth JB, Hamilton SB: Polychlorinated biphenyls modulated tumorigenesis in Sprague Dawley rats: correlation with mixed function oxidase activities and superoxide (O2* ) formation potentials and implied mode of action. Toxicol Sci; 2007 Aug;98(2):375-94
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  • Parallel, chronic (24 months) multidose bioassays of the PCB (polychlorinated biphenyls) Aroclors 1016, 1242, 1254, and 1260 in male and female Sprague-Dawley rats showed sex/Aroclor-dependent increases in hepatic tumors and decreases in extrahepatic tumors.
  • To elucidate the PCB mode of action (MOA) involved, levels of a number of hypothesized mediators were measured in liver specimens collected at 3, 6, 12, 18, and 24 months and screened for correlation with late life hepatotumorigenesis (HT; mostly adenomas).
  • Consistently correlated with HT were (1) tissue accumulations of SigmaPCBs (correlated in both sexes) and of dioxin equivalents (toxic equivalency [TEQ]; correlated in females only);.
  • The new findings, along with other recently reported relationships, were indicative of a MOA consisting of (1) SigmaPCB/TEQ accumulation in rat tissues;.
  • (6) O(2)(*-) dismutation to H(2)O(2); and (7) H(2)O(2)-mediated mitotic signaling, resulting in the proliferation of spontaneously or otherwise initiated cells to form hepatic tumors, as in tumor promotion.
  • [MeSH-major] Carcinogens / toxicity. Liver Neoplasms / chemically induced. Liver Neoplasms / metabolism. Polychlorinated Biphenyls / toxicity
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / metabolism. Adipose Tissue / metabolism. Alanine Transaminase / blood. Animals. Aryl Hydrocarbon Hydroxylases / metabolism. Brain / metabolism. Cytochrome P-450 CYP1A1 / metabolism. Cytochrome P-450 CYP2B1 / metabolism. Female. Glutathione Peroxidase / metabolism. Liver / drug effects. Liver / metabolism. Liver / pathology. Male. Microsomes, Liver / enzymology. Rats. Rats, Sprague-Dawley. Steroid Hydroxylases / metabolism. Superoxides / metabolism

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  • (PMID = 17510085.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 11062-77-4 / Superoxides; DFC2HB4I0K / Polychlorinated Biphenyls; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.14.- / Steroid Hydroxylases; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 1.14.14.1 / Cytochrome P-450 CYP2B1; EC 1.14.14.1 / steroid 16-beta-hydroxylase; EC 2.6.1.2 / Alanine Transaminase
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82. Jakobiec FA, Pineda R, Rivera R, Hsu-Winges C, Cherwek D: Epicorneal polypoidal lipodermoid: lack of association of central corneal lesions with goldenhar syndrome verified with a review of the literature. Surv Ophthalmol; 2010 Jan-Feb;55(1):78-84
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  • We describe a dramatic central epicorneal polypoidal lipodermoid coloboma accompanied by an upper eyelid coloboma that was not associated with Goldenhar syndrome.
  • This last feature is not present in normal eyelid skin nor in the conjunctiva, and has not been previously documented to occur in epibulbar dermoids and lipodermoids.
  • Beneath the dermis was a massive collection of lobules of mature adipose tissue that fused with the corneal stroma.
  • A virtually identical pedunculated limbal tumor has been previously reported that was associated with Goldenhar syndrome.
  • Review of earlier published cases of epibulbar dermoids and lipodermoids establishes that central corneal lesions are not a stigma of Goldenhar syndrome, in contrast to limbal masses.
  • [MeSH-major] Coloboma / pathology. Corneal Diseases / pathology. Dermoid Cyst / pathology. Eye Neoplasms / pathology. Eyelids / abnormalities. Goldenhar Syndrome / pathology


83. Requena L: Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides. Semin Cutan Med Surg; 2007 Jun;26(2):66-70
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  • The specific diagnosis of these diseases requires histopathologic study because different panniculitides usually show the same clinical appearance, which consists of erythematous nodules on the lower extremities.
  • However, nearly always the differential diagnosis between a mostly septal and a mostly lobular panniculitis is straightforward at scanning magnification on the basis of the structures more intensely involved by the inflammatory infiltrate.
  • Finally, some cutaneous lymphomas may simulate panniculitis, both from clinical and histopathologic points of view and, for that reason, they will be included in this review, although they are not inflammatory processes, but authentic lymphocytic neoplasms involving subcutaneous tissue.
  • [MeSH-major] Adipocytes / pathology. Adipose Tissue / anatomy & histology. Adipose Tissue / pathology. Panniculitis / classification

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  • (PMID = 17544956.001).
  • [ISSN] 1085-5629
  • [Journal-full-title] Seminars in cutaneous medicine and surgery
  • [ISO-abbreviation] Semin Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 6
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84. Heiba SI, Bernik S, Raphael B, Sandella N, Cholewinski W, Klein P: The distinctive role of positron emission tomography/computed tomography in breast carcinoma with brown adipose tissue 2-fluoro-2-deoxy-d-glucose uptake. Breast J; 2005 Nov-Dec;11(6):457-61
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  • [Title] The distinctive role of positron emission tomography/computed tomography in breast carcinoma with brown adipose tissue 2-fluoro-2-deoxy-d-glucose uptake.
  • The precise anatomic localization of FDG uptake with CT in a PET/CT scan of a patient with known breast carcinoma helped identify a contralateral breast tumor with axillary lymph node metastasis despite the presence of extensive physiologic brown fat FDG uptake.
  • Accordingly, the patient received appropriate surgical management and pathologic confirmation of the disease.
  • [MeSH-major] Breast Neoplasms / radiography. Breast Neoplasms / radionuclide imaging. Carcinoma / radiography. Carcinoma / radionuclide imaging. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging
  • [MeSH-minor] Adipose Tissue, Brown / chemistry. Adult. Female. Fluorodeoxyglucose F18 / pharmacokinetics. Humans. Lymphatic Metastasis / radiography. Lymphatic Metastasis / radionuclide imaging. Neoplasm Staging. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 16297092.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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85. Tanas MR, Sthapanachai C, Nonaka D, Melamed J, Oliveira AM, Erickson-Johnson MR, Rubin BP: Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric adipose tissue adjacent to renal cell carcinoma: a lesion mimicking well-differentiated liposarcoma. Mod Pathol; 2009 Sep;22(9):1196-200
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  • [Title] Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric adipose tissue adjacent to renal cell carcinoma: a lesion mimicking well-differentiated liposarcoma.
  • Cytologically atypical stromal cells were found in the perinephric adipose tissue, mimicking well-differentiated liposarcoma in 12 of 59 (20%) consecutive nephrectomy specimens that were resected for renal cell carcinoma.
  • Of 59, 10 (17%) renal cell carcinomas invaded through the renal capsule into the perinephric adipose tissue.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Fibroblasts / pathology. Kidney Neoplasms / pathology. Liposarcoma / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence

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  • (PMID = 19525929.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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86. Heffernan EJ, Lefaivre K, Munk PL, Nielsen TO, Masri BA: Ossifying lipoma of the thigh. Br J Radiol; 2008 Aug;81(968):e207-10
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  • Lipomas are common soft-tissue tumours that are usually found in the subcutaneous adipose tissue.
  • Occasionally, they may contain mesenchymal elements other than adipose tissue, including osseous components.
  • These ossifying lipomas are usually located near or within bone, and it is very rare for a lipoma with no connection to bone to contain mature osseous tissue.
  • We describe a case of a symptomatic ossifying intramuscular lipoma of the thigh.
  • [MeSH-major] Lipoma / diagnosis. Muscle Neoplasms / diagnosis. Ossification, Heterotopic / diagnosis. Quadriceps Muscle

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  • (PMID = 18628326.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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87. Prabhudesai AG, Dalton P, Kumar D, Finlayson CJ: Mechanised one-day fat clearance method to increase the lymph node yield in rectal cancer specimens. Br J Biomed Sci; 2005 Jan;62(3):120-123
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  • Here, a simple, effective and economical solution to the problem is described, which should be amenable to any laboratory with a spare or back-up tissue-processing machine.

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  • (PMID = 28700864.001).
  • [ISSN] 0967-4845
  • [Journal-full-title] British journal of biomedical science
  • [ISO-abbreviation] Br. J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Adipose tissue / Colorectal neoplasms / Lymph node excision / Tissue preservation
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88. Amemori S, Ootani A, Aoki S, Fujise T, Shimoda R, Kakimoto T, Shiraishi R, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K: Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro. Am J Physiol Gastrointest Liver Physiol; 2007 Mar;292(3):G923-9
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  • The aim of the present study was to clarify the effects of adipose tissue on colon cancer proliferation by using cultured cell lines.
  • To achieve this, colon cancer cells (CACO-2, T84, and HT29) were cocultured with adipose tissue, isolated mature adipocytes, and isolated preadipocytes in a three-dimensional collagen gel culture system.
  • The adipose tissue, mature adipocytes, and preadipocytes isolated from C57BL/6J mice significantly increased the proliferation of the colon cancer cells.
  • This trophic effect of mature adipocytes on the cancer cell lines was observed only for cells from lean littermates and not for those from ob/ob mice.
  • In contrast, the trophic effect of preadipocytes was not abolished in ob/ob mice, and this finding was supported by the result that leptin had a trophic effect on cancer cells.
  • In conclusion, adipocytes were able to enhance the proliferation of colon cancer cells in vitro, partly via leptin, suggesting that adipose tissues, including mature adipocytes and preadipocytes, may promote the growth of colorectal cancer.
  • [MeSH-minor] Adipose Tissue / cytology. Adipose Tissue / metabolism. Animals. Caco-2 Cells. Cell Line, Tumor. Coculture Techniques / methods. Collagen / chemistry. Colonic Neoplasms / pathology. Gels. HT29 Cells. Humans. Leptin / deficiency. Leptin / genetics. Mice. Mice, Inbred C57BL. Mice, Knockout. Mice, Obese. Receptors, Cell Surface / analysis. Receptors, Leptin. Stromal Cells / pathology

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  • (PMID = 17170030.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gels; 0 / Leptin; 0 / Receptors, Cell Surface; 0 / Receptors, Leptin; 9007-34-5 / Collagen
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89. Prokopakis E, Raissaki M, Bourolias C, Karatzanis A, Velegrakis G: Massive plexiform neurofibroma and spinal deformity presenting as dysphagia. Am J Otolaryngol; 2007 Jul-Aug;28(4):280-3
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  • Dysphagia is a symptom associated with various diseases of the upper gastrointestinal and respiratory tract, and it may be the presenting symptom of numerous tumors of the head and neck.
  • Plexiform neurofibromas (PNFs) are benign tumors of the peripheral nerves and connective tissue, which are usually associated with neurofibromatosis type 1.
  • We present a rare case of a 52-year-old woman presenting with dysphagia and weight loss due to a massive PNF in the subcutaneous adipose tissue of the posterior neck, associated with C1-C2 dislocation, scoliosis of the vertebral column, and 2 meningoceles consistent with the diagnosis of neurofibromatosis type 1.
  • [MeSH-major] Deglutition Disorders / etiology. Head and Neck Neoplasms / complications. Neurofibroma, Plexiform / complications
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Severity of Illness Index. Tomography, X-Ray Computed


90. Okuda Y, Mori Y, Katoh Y, Iguchi M, Katoh M, Yamazaki D: [Case of small cell carcinoma of the urinary bladder effectively treated with adjuvant chemotherapy and radiotherapy following TUR]. Hinyokika Kiyo; 2009 May;55(5):267-9
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  • We suspected carcinoma in situ but two months after cystoscopy showed a non-papillary and sessile tumor with calcification.
  • We performed transurethral resection of the bladder tumor, muscle layer and adipose tissue.
  • Histopathological findings revealed small cell carcinoma of the bladder infiltrating the externaladipose tissue.
  • Follow up magnetic resonance imaging revealed disappearance of the bladder tumor.
  • [MeSH-major] Carcinoma, Small Cell / therapy. Urinary Bladder Neoplasms / therapy

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  • (PMID = 19507545.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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91. Stephens NA, Skipworth RJ, Fearon KC: Cachexia, survival and the acute phase response. Curr Opin Support Palliat Care; 2008 Dec;2(4):267-74
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  • It results from anorexia and metabolic change and leads to loss of both adipose tissue and lean body mass, particularly in the skeletal muscle compartment.
  • [MeSH-minor] Adipose Tissue / metabolism. C-Reactive Protein / metabolism. Humans. Interleukin-6 / metabolism. Muscle, Skeletal / metabolism. Muscular Atrophy / etiology. Muscular Atrophy / metabolism. Neoplasms / complications. Neoplasms / metabolism. Neoplasms / mortality. Weight Loss

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  • (PMID = 19060563.001).
  • [ISSN] 1751-4266
  • [Journal-full-title] Current opinion in supportive and palliative care
  • [ISO-abbreviation] Curr Opin Support Palliat Care
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines; 0 / Inflammation Mediators; 0 / Interleukin-6; 9007-41-4 / C-Reactive Protein
  • [Number-of-references] 75
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92. Brown C, Jones A: Bladder lipoma associated with urinary tract infection. ScientificWorldJournal; 2008;8:573-4
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  • Lipomas are benign overgrowths of adipose tissue.
  • They are an unusual finding within the bladder wall.
  • [MeSH-major] Lipoma / complications. Urinary Bladder Neoplasms / complications. Urinary Tract Infections / complications


93. Fujimoto T, Koyanagi M, Baba I, Nakabayashi K, Kato N, Sasazuki T, Shirasawa S: Analysis of KRAP expression and localization, and genes regulated by KRAP in a human colon cancer cell line. J Hum Genet; 2007;52(12):978-84
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  • Here, we have generated a specific polyclonal antibody for KRAP and characterized the histological expression of KRAP in mouse tissues.
  • KRAP was ubiquitously expressed in mouse tissues, with high levels in pancreas, liver, and brown adipose tissues, and KRAP was co-localized with filamentous actin along the apical membranes in both pancreas and liver tissues.
  • [MeSH-major] Colonic Neoplasms / chemistry. Gene Expression Regulation, Neoplastic. Membrane Proteins / genetics. Membrane Proteins / physiology. Microfilament Proteins / genetics. Microfilament Proteins / physiology
  • [MeSH-minor] Actins / metabolism. Animals. Cell Line, Tumor. Humans. Immunohistochemistry. Mice. Tissue Distribution

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  • (PMID = 17934691.001).
  • [ISSN] 1434-5161
  • [Journal-full-title] Journal of human genetics
  • [ISO-abbreviation] J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Actins; 0 / KRAP protein, human; 0 / Membrane Proteins; 0 / Microfilament Proteins
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94. Lu M, Chen D, Lin Z, Reierstad S, Trauernicht AM, Boyer TG, Bulun SE: BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells. J Clin Endocrinol Metab; 2006 Nov;91(11):4514-9
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  • [Title] BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells.
  • OBJECTIVE: Because excessive estrogen production increases the risk of breast cancer, we determined whether BRCA1 suppresses aromatase expression and thus local estrogen production in breast adipose fibroblasts (BAFs) and breast malignant epithelial cells by interacting with the cancer-associated promoter I.3/II region of the aromatase gene.
  • CONCLUSIONS: Selective inhibition of aromatase expression by BRCA1 binding to the I.3/II tumorigenic promoter region may be an important protective mechanism against breast cancer development.
  • [MeSH-major] Adipose Tissue / metabolism. Aromatase / genetics. BRCA1 Protein / metabolism. Breast / cytology. Breast Neoplasms / metabolism. Carcinoma / metabolism. Epithelial Cells / metabolism. Promoter Regions, Genetic
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols. Bucladesine / pharmacology. Cell Line, Tumor. DNA-Binding Proteins / metabolism. Dinoprostone / pharmacology. Female. Fibroblasts / enzymology. Fibroblasts / metabolism. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Phorbol Esters / pharmacology. RNA Interference. Transcription Factors / metabolism. Tumor Cells, Cultured

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  • (PMID = 16940443.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA67167
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BRCA1 Protein; 0 / DNA-Binding Proteins; 0 / Phorbol Esters; 0 / Transcription Factors; 24928-15-2 / phorbol-12,13-diacetate; 63X7MBT2LQ / Bucladesine; EC 1.14.14.1 / Aromatase; K7Q1JQR04M / Dinoprostone
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95. Kuzmiak CM, Pisano ED, Cole EB, Zeng D, Burns CB, Roberto C, Pavic D, Lee Y, Seo BK, Koomen M, Washburn D: Comparison of full-field digital mammography to screen-film mammography with respect to contrast and spatial resolution in tissue equivalent breast phantoms. Med Phys; 2005 Oct;32(10):3144-50
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  • [Title] Comparison of full-field digital mammography to screen-film mammography with respect to contrast and spatial resolution in tissue equivalent breast phantoms.
  • Tissue equivalent breast phantoms simulating an adipose to glandular ratio of 50/50,30/70, and 20/80 were imaged according to each manufacturers' recommendation with four full-field digital mammography units (Fuji, Sectra, Fischer, and General Electric) and a screen-film mammography unit (MammoMatII 2000, Siemens, Munich, Germany).
  • A total of 20 images were obtained in both hard- and soft-copy formats.
  • For the purpose of soft-copy display, the screen-film hard-copy images were digitized with a 50 microm micron scanner.
  • For the digital mammography units, soft-copy display performed better than hard-copy display for the Fischer and Sectra images, but worse for Fuji and General Electric.
  • In addition, soft-copy display of digitized screen-film images was significantly better than hard-copy display (p =0.02) of the original screen films for object visibility, but worse for spatial resolution.
  • The higher contrast resolution of the FFDM units tested did not result in improved detection of line-pair resolution or objects in the phantoms tested versus screen-film mammography.
  • The phantom performance of a digital mammography unit seems to be influenced by the type of detection task (line-pair resolution versus object visibility), the display modality (soft-copy versus hard-copy) chosen to score the phantoms, and the parenchymal pattern composition of the phantom.
  • [MeSH-major] Breast Neoplasms / diagnostic imaging. Mammography / methods. Radiographic Image Enhancement / instrumentation. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods. X-Ray Intensifying Screens

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  • (PMID = 16279068.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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96. Bossola M, Pacelli F, Doglietto GB: Novel treatments for cancer cachexia. Expert Opin Investig Drugs; 2007 Aug;16(8):1241-53
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  • Cancer cachexia is a debilitating and life-threatening syndrome characterised by anorexia, body weight loss, loss of adipose tissue and skeletal muscle, and accounts for > or = 20% of deaths in neoplastic patients.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Cachexia / drug therapy. Drugs, Investigational / therapeutic use. Neoplasms / drug therapy

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  • (PMID = 17685872.001).
  • [ISSN] 1744-7658
  • [Journal-full-title] Expert opinion on investigational drugs
  • [ISO-abbreviation] Expert Opin Investig Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drugs, Investigational
  • [Number-of-references] 125
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97. Motrescu ER, Rio MC: Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle. Biol Chem; 2008 Aug;389(8):1037-41
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  • [Title] Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle.
  • It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment.
  • MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation.
  • Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression.
  • This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.
  • [MeSH-major] Adipocytes / enzymology. Matrix Metalloproteinase 11 / metabolism. Neoplasms / enzymology. Neoplasms / pathology
  • [MeSH-minor] Animals. Cell Communication. Disease Progression. Humans. Neoplasm Staging

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  • (PMID = 18979628.001).
  • [ISSN] 1431-6730
  • [Journal-full-title] Biological chemistry
  • [ISO-abbreviation] Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinase 11
  • [Number-of-references] 46
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98. Lazebnik M, Popovic D, McCartney L, Watkins CB, Lindstrom MJ, Harter J, Sewall S, Ogilvie T, Magliocco A, Breslin TM, Temple W, Mew D, Booske JH, Okoniewski M, Hagness SC: A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries. Phys Med Biol; 2007 Oct 21;52(20):6093-115
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  • [Title] A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries.
  • The development of microwave breast cancer detection and treatment techniques has been driven by reports of substantial contrast in the dielectric properties of malignant and normal breast tissues.
  • However, definitive knowledge of the dielectric properties of normal and diseased breast tissues at microwave frequencies has been limited by gaps and discrepancies across previously published studies.
  • To address these issues, we conducted a large-scale study to experimentally determine the ultrawideband microwave dielectric properties of a variety of normal, malignant and benign breast tissues, measured from 0.5 to 20 GHz using a precision open-ended coaxial probe.
  • Previously, we reported the dielectric properties of normal breast tissue samples obtained from reduction surgeries.
  • Here, we report the dielectric properties of normal (adipose, glandular and fibroconnective), malignant (invasive and non-invasive ductal and lobular carcinomas) and benign (fibroadenomas and cysts) breast tissue samples obtained from cancer surgeries.
  • Our analyses show that the contrast in the microwave-frequency dielectric properties between malignant and normal adipose-dominated tissues in the breast is considerable, as large as 10:1, while the contrast in the microwave-frequency dielectric properties between malignant and normal glandular/fibroconnective tissues in the breast is no more than about 10%.
  • [MeSH-major] Breast / physiopathology. Breast Neoplasms / physiopathology. Microwaves. Models, Biological

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  • (PMID = 17921574.001).
  • [ISSN] 0031-9155
  • [Journal-full-title] Physics in medicine and biology
  • [ISO-abbreviation] Phys Med Biol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 087007
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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99. Hardes J, Scheil-Bertram S, Hartwig E, Gebert C, Gosheger G, Schulte M: Sonographic findings of hibernoma. A report of two cases. J Clin Ultrasound; 2005 Jul-Aug;33(6):298-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present 2 cases of hibernoma, a rare lipomatous tumor arising from brown fat tissue.
  • In each case, a hyperechoic mass in comparison to surrounding musculature combined with elevated vascularization was highly suggestive of a liposarcoma.
  • Although rare, hibernomas should be considered in the differential diagnosis of lipomatous soft-tissue tumors.
  • [MeSH-major] Adipose Tissue, Brown / ultrasonography. Lipoma / diagnosis. Soft Tissue Neoplasms / diagnosis. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adult. Biopsy, Needle / methods. Buttocks / pathology. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Gadolinium DTPA. Humans. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Male. Rare Diseases. Tomography, X-Ray Computed / methods

  • Hazardous Substances Data Bank. GADOPENTETATE DIMEGLUMINE .
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  • (PMID = 16134158.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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100. Keyriläinen J, Fernández M, Fiedler S, Bravin A, Karjalainen-Lindsberg ML, Virkkunen P, Elo EM, Tenhunen M, Suortti P, Thomlinson W: Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology. Eur J Radiol; 2005 Feb;53(2):226-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Visualisation of calcifications and thin collagen strands in human breast tumour specimens by the diffraction-enhanced imaging technique: a comparison with conventional mammography and histology.
  • Six excised human breast tissue specimens carrying benign and malignant tumours were examined with the diffraction-enhanced imaging technique.
  • Fine details of the structures such as strands of collagen and contours between glandular and adipose tissue, which are barely visible at the contrast detection limit in the conventional absorption-based mammograms, are clearly visible in the diffraction-enhanced images.
  • Microscopic study of the stained histopathological sections unequivocally confirms the correlation of the radiographic findings with the morphologic changes in specimens.
  • An increased soft tissue contrast and a combination of information obtained with disparate diffraction-enhanced images provide better visibility of mammographically indistinguishable features.
  • This kind of additional structural information of the breast tissue is required to improve assessment accuracy and earlier detection of the breast lesions.
  • [MeSH-major] Breast Neoplasms / radiography. Calcinosis / radiography. Collagen. Radiographic Image Enhancement / methods. X-Ray Diffraction / methods

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  • (PMID = 15664286.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 9007-34-5 / Collagen
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