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1. Arikawa S, Uchida M, Shinagawa M, Tohnan T, Hayabuchi N: Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst. Kurume Med J; 2006;53(1-2):37-40
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  • [Title] Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst.
  • Although a series of imaging studies suggested a lipomatous tumor, diagnosis was difficult because the tumor appeared as a pedunculated mass extending from the uterine body.
  • To distinguish the tumor from an ovarian lipomatous tumor, the "beak sign" in a magnetic resonance imaging study was diagnostic in this case.
  • The purpose of this paper is to review lipomatous masses of the female pelvis, to discuss the differential diagnosis of the unusual imaging features, and to discuss imaging techniques to optimize pelvic mass characterization.
  • [MeSH-major] Leiomyoma / diagnosis. Lipoma / diagnosis. Ovarian Cysts / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17043394.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Walter M, Liang S, Ghosh S, Hornsby PJ, Li R: Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene; 2009 Jul 30;28(30):2745-55
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  • [Title] Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells.
  • Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated.
  • Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model.
  • Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs.
  • Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells.

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  • (PMID = 19483720.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA093506-08; United States / NCI NIH HHS / CA / R01 CA093506; United States / NCI NIH HHS / CA / R01 CA093506-05A1; United States / NCI NIH HHS / CA / CA093506-05A1; United States / NCI NIH HHS / CA / CA93506; United States / NCI NIH HHS / CA / CA093506-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cofilin 1; 0 / Interleukin-6; 0 / ROCK1 protein, human; EC 2.7.11.1 / rho-Associated Kinases
  • [Other-IDs] NLM/ NIHMS111638; NLM/ PMC2806057
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3. Zemel MB, Sun X: Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr; 2008 Jun;138(6):1047-52
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  • Accordingly, this study was designed to study the effects of the short-term (3 wk) basal suboptimal Ca (0.4%), high-Ca (1.2% from CaCO(3)), and high-dairy (1.2% Ca from milk) obesigenic diets on oxidative and inflammatory stress in adipocyte fatty acid-binding protein-agouti transgenic mice.
  • Adipose tissue reactive oxygen species (ROS) production and NADPH oxidase mRNA and plasma malondialdehyde (MDA) were reduced by the high-Ca diet (P < 0.001) compared with the basal diet and ROS and MDA were further decreased by the high-dairy diet (P < 0.001).
  • The high-Ca and -dairy diets also resulted in suppression of adipose tissue tumor necrosis factor alpha and interleukin (IL)-6 mRNA (P = 0.001) compared with the basal diet, whereas an inverse pattern was noted for adiponectin and IL-15 mRNA (P = 0.002).
  • These data demonstrate that dietary Ca suppresses adipose tissue oxidative and inflammatory stress.

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  • (PMID = 18492832.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Calcium, Dietary; 0 / Dietary Carbohydrates; 0 / Dietary Fats; 9007-41-4 / C-Reactive Protein
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4. Kucerova L, Altanerova V, Matuskova M, Tyciakova S, Altaner C: Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res; 2007 Jul 1;67(13):6304-13
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  • [Title] Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy.
  • Human adipose tissue-derived mesenchymal stem cells (AT-MSC) are considered to be a promising source of autologous stem cells in personalized cell-based therapies.
  • Tumor tracking properties of MSC provide an attractive opportunity for targeted transgene delivery into the sites of tumor formation.
  • In the present study, we addressed whether the suicide gene introduction into human AT-MSC could produce a tumor-specific prodrug converting cellular vehicle for targeted chemotherapy.
  • Gene manipulation of human AT-MSC did not sensitize CD-AT-MSC to 5-FC, thus overcoming the inherent disadvantage of suicide effect on cellular vehicle.
  • CD-AT-MSC in combination with 5-FC augmented the bystander effect and selective cytotoxicity on target tumor cells HT-29 in direct coculture in vitro.
  • We confirmed directed migration ability of AT-MSC and CD-AT-MSC toward tumor cells HT-29 in vitro.
  • Moreover, we achieved significant inhibition of s.c. tumor xenograft growth by s.c. or i.v. administered CD-AT-MSC in immunocompromised mice treated with 5-FC.
  • We confirmed the ability of CD-AT-MSC to deliver the CD transgene to the site of tumor formation and mediate strong antitumor effect in vivo.
  • Taken together, these data characterize MSC derived from adipose tissue as suitable delivery vehicles for prodrug converting gene and show their utility for a personalized cell-based targeted cancer gene therapy.
  • [MeSH-major] Adipose Tissue / metabolism. Antineoplastic Agents / pharmacology. Flucytosine / pharmacology. Gene Expression Regulation. Genetic Therapy / methods. Mesenchymal Stromal Cells / cytology. Neoplasms / drug therapy. Prodrugs / pharmacology
  • [MeSH-minor] Animals. Cell Line, Tumor. Cytosine Deaminase / genetics. Cytosine Deaminase / metabolism. Female. Humans. Mice. Mice, Inbred BALB C. Neoplasm Transplantation

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  • (PMID = 17616689.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Prodrugs; D83282DT06 / Flucytosine; EC 3.5.4.1 / Cytosine Deaminase
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5. Kabasawa Y, Katsube K, Harada H, Nagumo K, Terasaki H, Perbal B, Okada N, Omura K: A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):677-82
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  • [Title] A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor.
  • METHODS: We examined morphological aspects of the tumor and immunohistochemical patterns.
  • RESULTS: Tumor proliferation was infiltrative, which did not show apparent encapsulation.
  • Positive immunoreactivity was found for CD-34, CD-99, Ki-67, and connective tissue growth factor/CCN2 in the fibrous region, S-100 in the adipose region, and Notch1 stain was observed in the eccrine sweat gland cells juxtaposed to the tumor adipose tissue, but no reactivity for Bcl-2, alphaSMA, Notch 2-4, CCN1, and CCN3.
  • Specific expression of CCN2 might be significant for the development of the tumor.
  • [MeSH-major] Fibroma / pathology. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Lipoma / pathology
  • [MeSH-minor] Adipose Tissue / chemistry. Adipose Tissue / pathology. Antigens, CD / analysis. Antigens, CD34 / analysis. Cell Adhesion Molecules / analysis. Connective Tissue Growth Factor. Humans. Immediate-Early Proteins / biosynthesis. Immunohistochemistry. Infant. Insulin-Like Growth Factor Binding Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Ki-67 Antigen / analysis. Male. Neoplasm Proteins / biosynthesis. Nephroblastoma Overexpressed Protein. Receptor, Notch1 / biosynthesis. S100 Proteins / analysis

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  • (PMID = 17466886.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / CTGF protein, human; 0 / Cell Adhesion Molecules; 0 / Immediate-Early Proteins; 0 / Insulin-Like Growth Factor Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / NOTCH1 protein, human; 0 / NOV protein, human; 0 / Neoplasm Proteins; 0 / Nephroblastoma Overexpressed Protein; 0 / Receptor, Notch1; 0 / S100 Proteins; 139568-91-5 / Connective Tissue Growth Factor
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6. Obora A, Kojima T, Kato T, Matsuda H, Horie H, Hashimoto H, Fukuta N, Takano Y, Okuda J, Ida K, Saio M: [An autopsy case of hepatocellular carcinoma in which sarcoma-like changes and peritoneal dissemination were observed after RFA/TACE treatment]. Gan To Kagaku Ryoho; 2009 Jul;36(7):1183-6
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  • Liver biopsy led to a diagnosis of well-differentiated hepatocellular carcinoma.
  • CT revealed pleural effusion/ascites and nodular tumor in the adipose tissue of the parietal peritoneum and mesentery around the liver.
  • Autopsy revealed a tumor involving the liver surface to the peritoneum, suggesting cancerous peritonitis.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Catheter Ablation. Chemoembolization, Therapeutic. Liver Neoplasms / therapy

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  • (PMID = 19620814.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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7. Nishida J, Ehara S, Shiraishi H, Tada H, Satoh T, Okada K, Shimamura T: Clinical findings of hibernoma of the buttock and thigh: rare involvements and extremely high uptake of FDG-PET. Med Sci Monit; 2009 Jul;15(7):CS117-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Hibernoma is a rare adipose tissue tumor of the soft tissue and the term is derived from the histological similarities to the brown fat found in hibernating animals.
  • This was not typical of liposarcoma and suggestive of hibernoma.
  • Biopsy specimens revealed a proliferation of adipose cells with vacuolated granular eosinophilic cytoplasm.
  • CONCLUSIONS: While occurrences in the buttock or thigh are exceedingly rare, hibernoma should be included in the differential diagnosis of an adipose tissue tumor in the thigh, even though the imaging findings mimic liposarcoma.
  • A correct diagnosis should be established to prevent over-surgery.

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  • (PMID = 19564831.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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8. Prantl L, Muehlberg F, Navone NM, Song YH, Vykoukal J, Logothetis CJ, Alt EU: Adipose tissue-derived stem cells promote prostate tumor growth. Prostate; 2010 Nov 1;70(15):1709-15
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  • [Title] Adipose tissue-derived stem cells promote prostate tumor growth.
  • BACKGROUND: Recent evidence indicates that cancer stem cells play an important role in tumor initiation and maintenance.
  • Additionally, the effect of tissue-resident stem cells located in the surrounding healthy tissue on tumor progression has been demonstrated.
  • While most knowledge has been derived from studies of breast cancer cells, little is known regarding the influence of tissue resident stem cells on the tumor biology of prostate cancer.
  • (1) subcutaneous injection of 10(6) MDA PCa 118b human prostate cancer cells into the upper back or (2) subcutaneous injection of 10(6) MDA PCa 118b cells mixed directly with 10(5) GFP-labeled human adipose tissue-derived stem cells (hASCs).
  • Tumor growth and volumes over the ensuing 3 weeks were assessed using calipers and micro-computed tomography.
  • Immunohistochemistry was performed to identify engrafted hASCs in tumor sections.
  • RESULTS: At 3 weeks after injection, the mean tumor volume in the MDA PCa 118b/hASC co-injection group (1019.95 ± 73.49 mm(3)) was significantly higher than that in the MDA PCa 118b-only group (308.70 ± 21.06 mm(3)).
  • Engrafted hASCs exhibited the nuclear marker of proliferation Ki67 and expressed markers for endothelial differentiation, indicating their engraftment in tumor vessels.
  • CONCLUSION: Our study revealed for the first time that ASCs subcutaneously co-injected with prostate cancer cells engraft and promote tumor progression.
  • Further evaluation of the cross-talk between tumor and local tissue-resident stem cells may lead to new strategies for prostate cancer therapy.
  • [MeSH-major] Adipose Tissue / cytology. Neoplastic Stem Cells / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Animals. Disease Models, Animal. Flow Cytometry. Immunophenotyping. Male. Mice. Mice, Nude. Neoplasm Transplantation / methods. Random Allocation. Tomography, X-Ray Computed

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  • (PMID = 20564322.001).
  • [ISSN] 1097-0045
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS612155; NLM/ PMC4977846
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9. Novikov VV, Novikov GV, Fesenko EE: Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics; 2009 Jul;30(5):343-51

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  • [Title] Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma.
  • It was shown that the exposure of mice with EAC to combined MFs causes structural changes in some organs (liver, adrenal glands), which are probably due to the total degradation of the tumor tissue.
  • In mice with transplanted EAC, the tumor tissue after exposure to weak MFs was practically absent, as distinct from control animals in which the invasion of the tumor into the adipose tissue surrounding the kidneys, mesenteric lymph nodes, and spermatic appendages was observed.
  • In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism.
  • [MeSH-major] Carcinoma, Ehrlich Tumor / pathology. Carcinoma, Ehrlich Tumor / therapy. Magnetic Field Therapy / methods. Magnetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19267367.001).
  • [ISSN] 1521-186X
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Kurita H, Kamata T, Koike T, Kobayashi H, Kurashina K: Intraoperative tissue staining of invaded oral carcinoma. Pathol Oncol Res; 2008 Dec;14(4):461-5
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  • [Title] Intraoperative tissue staining of invaded oral carcinoma.
  • The purpose of this study was to assess the ability of intraoperative tissue staining with consecutive application of 0.4% indigo carmine and 0.5% Congo red to demonstrate the extent and border of oral carcinoma invasion.
  • Once the oral tumor was resected, a vertical section of surgical specimen was taken from the central part of the tumor.
  • The extent and border of the invaded carcinoma were assessed on digital microscopic examination with tissue staining.
  • Tissue staining produced a brown-black stain on normal muscle, connective, and salivary tissues but not tumor and epithelial tissues.
  • It clearly demonstrated the extent and border of tumor invasion in 13 of 17 patients (76.5%); however, detection of remnant vital tumor cells in scar tissue after neoadjuvant chemotherapy, and distinction between the tumor and adipose tissue scattered in the muscle tissue was difficult.
  • The results of this study showed that intraoperative tissue staining was a possible method in demonstrating the extent and border of carcinoma deeply invaded in the soft tissue and selecting the site for additional frozen section analysis, although the method needed some refinement.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neoplasm Staging / methods. Staining and Labeling / methods

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  • (PMID = 18575826.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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11. de Groot M, Appelman M, Spuls PI, de Rie MA, Bos JD: Initial experience with routine administration of etanercept in psoriasis. Br J Dermatol; 2006 Oct;155(4):808-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: We hypothesized: (i) that efficacy would be lower than that obtained in published phase II and III studies because (a) resistance to all conventional therapies as a reimbursement condition would select for more resistant cases and (b) inclusion would be more restricted to severe cases (higher PASI), and (ii) that efficacy would be lower in obese patients due to the possible role of adipose tissue in tumour necrosis factor (TNF)-alpha homeostasis.
  • Additionally, we related the clinical effect to the body mass index (BMI), for adipose tissue is thought to have a possible role in TNF-alpha homeostasis.
  • Although fatigue is not identified as a side-effect of etanercept, 10% of our patients reported fatigue as an adverse event during etanercept treatment.
  • Finally, the BMI does not seem to influence the patients' response to etanercept, although further investigations would be needed to confirm this.
  • [MeSH-major] Dermatologic Agents / therapeutic use. Immunoglobulin G / therapeutic use. Psoriasis / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use

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  • (PMID = 16965432.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; OP401G7OJC / Etanercept
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12. Marsilia GM, Boscaino A, La Mura A, Ceriello A, De Ritis R: Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? Int J Surg Pathol; 2010 Dec;18(6):537-9
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  • Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45.
  • The tumor cells of intramural small intestinal mass were positive for S-100 protein and GFAP and negative for CD117, CD34 and desmin.
  • [MeSH-major] Angiomyolipoma / pathology. Jejunal Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19282295.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Cheng H, Dodge J, Mehl E, Liu S, Poulin N, van de Rijn M, Nielsen TO: Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays. Hum Pathol; 2009 Sep;40(9):1244-51
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  • [Title] Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays.
  • Expression profiling followed by tissue microarray validation linked to patient outcome is a powerful approach for validating biological mechanisms and identifying prognostic biomarkers.
  • We applied these techniques to independent series of primary myxoid liposarcomas in an effort to assess markers of adipose differentiation in myxoid liposarcoma and to identify prognostic markers that can be efficiently assessed by immunohistochemistry.
  • Candidate genes were selected based on analysis of expression profiles from 9 primary myxoid/round liposarcomas and 45 other soft tissue tumors, and by reference to publicly available data sets.
  • Protein products were validated on an adipose neoplasm tissue microarray, including 32 myxoid liposarcomas linked to patient outcome.
  • [MeSH-major] Adipogenesis. Biomarkers, Tumor / analysis. Liposarcoma, Myxoid / genetics. Soft Tissue Neoplasms / genetics. Tissue Array Analysis / methods

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  • (PMID = 19368956.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin-Like Growth Factor Binding Protein 2; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / Receptor, IGF Type 1
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14. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • [Title] Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation.
  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years.
  • Four tumors predominantly showed features of schwannoma and one of neurofibroma; however, intimately admixed with the spindle cell population, there were also numerous scattered mature adipocytes as well as lipoblast-like cells displaying a signet-ring cell appearance.
  • The signet-ring cells were negative for mucin stains, cytokeratin, EMA, CEA, and several other differentiation markers.
  • The signet-ring cells contained large cytoplasmic lipid droplets that displaced the nuclei to the periphery, consistent with lipoblastic differentiation, whereas complex, interdigitating cytoplasmic processes covered by basal lamina material characteristic of nerve sheath differentiation could be identified in the spindle cells.
  • The presence of mature fat and signet-ring lipoblast-like cells within a nerve sheath neoplasm is quite rare and may signify a process of aberrant differentiation.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-major] Adipose Tissue / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Carroll PA, Healy L, Lysaght J, Griffin M, Dunne B, Boyle MT, Reynolds JV, Kennedy MJ, Pidgeon G, Connolly EM: Mammary adipose tissue and cancer cell growth: The role of adipose tissue in the tumor microenvironment. J Clin Oncol; 2009 May 20;27(15_suppl):e22009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary adipose tissue and cancer cell growth: The role of adipose tissue in the tumor microenvironment.
  • Adipose tissue is considered an important endocrine organ producing several important hormones and cytokines including leptin and adiponectin.
  • Mechanisms for the role of obesity in cancer states includes the excess or unregulated secretion of adipocytokines from adipose tissue, and potentially the metabolic syndrome (a cluster of co-morbidities linked to metabolic dysregulation).
  • Mammary adipose tissue is proposed to play a vital role in the microenvironment of normal and tumour states within the breast<sup>2</sup>.
  • Breast adipose tissue is a good candidate to investigate effects of obesity and metabolic disturbances on cancer states.
  • METHODS: Peritumoural (PT) adipose tissue adjacent to the tumour and distal adipose tissue (D) within the breast was sampled in 10 patients.
  • The tissue was processed and cultured for 72hrs in serum free minimal cytokine media.
  • The adipocytokine profile at the mRNA and protein level was measured in ACM and adipose tissue for comparative differences using RT-PCR, ELISA and Cytokine Profiler technology.
  • RESULTS: ACM from both sites promoted tumour cell survival.
  • This may be mediated through increased pro-inflammatory or pro- mitogenic adipocytokine production in adipose tissue surrounding tumour.

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  • (PMID = 27963182.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Stillaert FB, Blondeel P, Hamdi M, Abberton K, Thompson E, Morrison WA: Adipose tissue induction in vivo. Adv Exp Med Biol; 2006;585:403-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adipose tissue induction in vivo.
  • Engineering adipogenic tissue in vivo requires the concomitant induction of angiogenesis to generate a stable long-term three-dimensional construct.
  • Histioconductive tissue engineering strategies have been used.
  • We evaluated an histioinductive approach for adipose tissue engineering by combining essential key components for adipogenic induction:.
  • (1) a precursor cell source, (2) a vascular pedicle, (3) a supportive matrix, and (4) a chamber to preserve space for the new tissue to develop.
  • We observed concomitant adipogenic and angiogenic induction after 6 weeks in three-dimensional adipose tissue constructs.
  • [MeSH-major] Adipose Tissue / pathology. Tissue Engineering / methods
  • [MeSH-minor] Animals. Biocompatible Materials / chemistry. Collagen / chemistry. Drug Combinations. Extracellular Matrix / metabolism. Guided Tissue Regeneration. Humans. Imaging, Three-Dimensional. Laminin / chemistry. Mesenchymal Stromal Cells / cytology. Mice. Muscle, Skeletal / cytology. Neoplasm Transplantation. Neovascularization, Pathologic. Proteoglycans / chemistry. Time Factors

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  • (PMID = 17120798.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Drug Combinations; 0 / Laminin; 0 / Proteoglycans; 119978-18-6 / matrigel; 9007-34-5 / Collagen
  • [Number-of-references] 26
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17. Scariot R, Giovanini AF, Torres-Pereira CC, Piazzetta CM, Costa DJ, Rebellato NL, Müller PR: Massive growth of an intraoral lipoma. J Contemp Dent Pract; 2008;9(7):115-21
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  • BACKGROUND: Lipoma, a benign tumor of adipose tissue, is rarely seen in the oral cavity.
  • A clinical diagnosis of lipoma was established, and the treatment consisted of complete excision of the mass under local anesthesia.
  • [MeSH-major] Cheek / pathology. Lipoma / pathology. Mouth Neoplasms / pathology

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  • (PMID = 18997924.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600

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  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.
  • With the aim of both diagnosis and treatment, the lipomatous mass was removed by local resection.
  • In addition to the patient's age, histologic and cytogenetic analyses assisted the diagnosis of diffuse lipoblastoma.
  • [MeSH-major] Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Miscusi G, di Gioia CR, Patrizi G, Gravetz A, Redler A, Petrozza V: Anatomical lymph node mapping in normal mesorectal adipose tissue. Dis Colon Rectum; 2010 Dec;53(12):1640-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anatomical lymph node mapping in normal mesorectal adipose tissue.
  • The adipose tissue was separated from the rectum and divided into 9 sections before fixing the specimen in paraffin, cutting into smaller portions, and staining with hematoxylin and eosin.
  • [MeSH-major] Adipose Tissue / anatomy & histology. Lymph Nodes / anatomy & histology. Rectum / anatomy & histology
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Cadaver. Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging / methods. Rectal Neoplasms / pathology. Staining and Labeling

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  • (PMID = 21178858.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Yamaguchi J, Ohtani H, Nakamura K, Shimokawa I, Kanematsu T: Prognostic impact of marginal adipose tissue invasion in ductal carcinoma of the breast. Am J Clin Pathol; 2008 Sep;130(3):382-8
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  • [Title] Prognostic impact of marginal adipose tissue invasion in ductal carcinoma of the breast.
  • This study aimed to investigate whether adipose tissue invasion (ATI) of cancer cells at the tumor margin influenced lymph node status and prognosis in patients with invasive ductal carcinoma of the breast.
  • Patients with ATI had a poorer prognosis than patients without ATI (10-year disease-free survival, 76% and 94%, respectively; P=.0323).
  • In addition, patients without ATI or LVI had neither lymph node metastasis (n=52) nor recurrent disease (n=53).
  • ATI is one of the biologic indicators of tumor aggressiveness.
  • [MeSH-major] Adipose Tissue / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis / pathology. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 18701411.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Murphy RA, Wilke MS, Perrine M, Pawlowicz M, Mourtzakis M, Lieffers JR, Maneshgar M, Bruera E, Clandinin MT, Baracos VE, Mazurak VC: Loss of adipose tissue and plasma phospholipids: relationship to survival in advanced cancer patients. Clin Nutr; 2010 Aug;29(4):482-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of adipose tissue and plasma phospholipids: relationship to survival in advanced cancer patients.
  • BACKGROUND & AIMS: Extensive loss of adipose tissue is a key feature of cancer cachexia.
  • It is not known whether these processes coincide across the cancer trajectory nor has their relationship with survival been defined.
  • Changes in adipose tissue mass and plasma phospholipids were characterized within 500days prior to death and prognostic significance assessed.
  • METHODS: Adipose tissue rate of change was determined in a retrospective cohort of patients who died of colorectal and lung cancers (n=108) and who underwent >2 computed tomography scans in the last 500days of life.
  • Plasma phospholipid fatty acids were measured prospectively in a similar cohort of patients with metastatic cancer (n=72).
  • RESULTS: Accelerated loss of adipose tissue begins at 7months from death reaching an average loss of 29% of total AT 2months from death.
  • Plasma phospholipid fatty acids were 35% lower in patients closest to death versus those surviving >8months.
  • Losses of phospholipid fatty acids and adipose tissue occur in tandem and are predictive of survival.
  • CONCLUSIONS: Depletion of plasma phospholipids likely indicates a deficit of essential fatty acids in the periphery which may contribute to loss of adipose tissue.
  • [MeSH-major] Adipose Tissue, White / metabolism. Adiposity. Cachexia / metabolism. Lipolysis. Neoplasms / physiopathology. Phospholipids / blood
  • [MeSH-minor] Aged. Cohort Studies. Disease Progression. Fatty Acids / blood. Female. Humans. Intra-Abdominal Fat / metabolism. Male. Middle Aged. Muscle, Skeletal / metabolism. Neoplasm Metastasis. Prognosis. Retrospective Studies. Subcutaneous Fat / metabolism. Survival Analysis

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  • [Copyright] Copyright 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
  • (PMID = 19959263.001).
  • [ISSN] 1532-1983
  • [Journal-full-title] Clinical nutrition (Edinburgh, Scotland)
  • [ISO-abbreviation] Clin Nutr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fatty Acids; 0 / Phospholipids
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22. Lopez IP, Milagro FI, Marti A, Moreno-Aliaga MJ, Martinez JA, De Miguel C: High-fat feeding period affects gene expression in rat white adipose tissue. Mol Cell Biochem; 2005 Jul;275(1-2):109-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-fat feeding period affects gene expression in rat white adipose tissue.
  • The expression of 76 sequences, previously isolated as differentially expressed in visceral white adipose tissue (WAT) of female rats, fed with a high-fat diet for 11 days (Lopez et al., Biochem Biophys Res Comm 318: 234-239, 2004), was analyzed in epidydimal WAT of male rats after a feeding period of 65 days with the same diet, using microarray technology.
  • After Northern blot validation of the results, only three genes appeared upregulated (caveolin-2, the alpha-1 chain of haemoglobin and rat mammary tumor-7) and two downregulated (adiponectin and dystroglycan).
  • Our results suggest that if feeding with a high-fat diet is prolonged, many of the initial changes in gene expression, probably aimed to consume the energy surplus and prevent excessive fat deposition, are not maintained, and adaptation to an increased lipid storage is developed.
  • [MeSH-major] Adipose Tissue / drug effects. Adipose Tissue / metabolism. Dietary Fats / administration & dosage. Gene Expression Regulation / drug effects
  • [MeSH-minor] Adiponectin / biosynthesis. Animals. Caveolin 2 / biosynthesis. Down-Regulation / drug effects. Dystroglycans / biosynthesis. Epididymis / metabolism. Hemoglobin A, Glycosylated / biosynthesis. Leptin / blood. Male. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis. Protein Biosynthesis. Proteins / genetics. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Rats. Rats, Wistar. Time Factors. Up-Regulation / drug effects. Weight Gain

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  • (PMID = 16335790.001).
  • [ISSN] 0300-8177
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Caveolin 2; 0 / Dietary Fats; 0 / Hemoglobin A, Glycosylated; 0 / Leptin; 0 / Neoplasm Proteins; 0 / Proteins; 0 / RMT-7 protein, rat; 0 / RNA, Messenger; 146888-27-9 / Dystroglycans
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23. Herrera-Herrera ML, Salazar-Olivo LA: RFamide neuropeptides inhibit murine and human adipose differentiation. Biochem Biophys Res Commun; 2008 Dec 5;377(1):29-34
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  • [Title] RFamide neuropeptides inhibit murine and human adipose differentiation.
  • Here, we show that NPFF, NPAF, and NPSF inhibited the differentiation of 3T3-F442A preadipocytes in a concentration-dependent manner, but had no effect on 3T3-L1 adipogenesis.
  • All three neuropeptides also blocked the adipose differentiation of normal and lipoma-derived human preadipocytes.
  • Our results show that NPFF, NPAF and NPSF negatively affect adipogenesis and suggest that these compounds participate in the regulation of the adipose tissue development by the central nervous system.
  • [MeSH-major] Adipogenesis / drug effects. Adipose Tissue / drug effects. Neuropeptides / pharmacology. Oligopeptides / pharmacology. Peptides / pharmacology
  • [MeSH-minor] 3T3-L1 Cells. Adipocytes / drug effects. Animals. Cell Line, Tumor. Humans. Inhibitor of Differentiation Proteins / biosynthesis. Mice. Neoplasm Proteins / biosynthesis

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  • (PMID = 18823948.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inhibitor of Differentiation Proteins; 0 / Neoplasm Proteins; 0 / Neuropeptides; 0 / Oligopeptides; 0 / Peptides; 0 / RFamide peptide; 0 / glutamyl-phenylalanyl-tryptophyl-seryl-leucyl-alanyl-alanyl-prolyl-glutaminyl-arginyl-phenylalaninamide; 147785-34-0 / ID3 protein, human; 99566-27-5 / phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide; 99588-52-0 / A18Famide
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24. Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS: Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell; 2008 Sep 19;134(6):933-44
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  • [Title] Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.
  • Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism.
  • Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperones aP2 and mal1, we explored how metabolic alterations in adipose tissue are linked to whole-body metabolism through lipid signals.
  • A robust increase in de novo lipogenesis rendered the adipose tissue of these mice resistant to the deleterious effects of dietary lipid exposure.
  • Systemic lipid profiling also led to identification of C16:1n7-palmitoleate as an adipose tissue-derived lipid hormone that strongly stimulates muscle insulin action and suppresses hepatosteatosis.
  • Our data reveal a lipid-mediated endocrine network and demonstrate that adipose tissue uses lipokines such as C16:1n7-palmitoleate to communicate with distant organs and regulate systemic metabolic homeostasis.

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  • [CommentIn] Cell. 2008 Sep 19;134(6):914-6 [18805083.001]
  • (PMID = 18805087.001).
  • [ISSN] 1097-4172
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK71507-04; United States / NIDDK NIH HHS / DK / DK071507-02; United States / NIDDK NIH HHS / DK / P30 DK040561; United States / NIDDK NIH HHS / DK / R90 DK071507; United States / NIDDK NIH HHS / DK / R01 DK064360-03; United States / NIDDK NIH HHS / DK / R01 DK064360; United States / NIDDK NIH HHS / DK / DK064360-03; United States / NIDDK NIH HHS / DK / P30 DK040561-13; United States / NIDDK NIH HHS / DK / R01 DK064360-04; United States / NIDDK NIH HHS / DK / DK064360-04; United States / NIDDK NIH HHS / DK / DK064360; United States / NIDDK NIH HHS / DK / R56 DK064360; United States / NIDDK NIH HHS / DK / DK071507-03; United States / NIDDK NIH HHS / DK / DK064360-05; United States / NIDDK NIH HHS / DK / R90 DK071507-02; United States / NIDDK NIH HHS / DK / DK040561-13; United States / NIDDK NIH HHS / DK / R90 DK071507-03; United States / NIDDK NIH HHS / DK / DK071507-04; United States / NIDDK NIH HHS / DK / R56 DK064360-05; United States / NIDDK NIH HHS / DK / R90 DK071507-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fabp4 protein, mouse; 0 / Fabp5 protein, mouse; 0 / Fatty Acid-Binding Proteins; 0 / Fatty Acids, Monounsaturated; 0 / Hormones; 0 / Insulin; 0 / Neoplasm Proteins; 209B6YPZ4I / palmitoleic acid; EC 1.14.19.1 / Scd1 protein, mouse; EC 1.14.19.1 / Stearoyl-CoA Desaturase
  • [Other-IDs] NLM/ NIHMS70845; NLM/ PMC2728618
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25. Oh TH, Byeon JS, Myung SJ, Yang SK, Choi KS, Chung JW, Kim B, Lee D, Byun JH, Jang SJ, Kim JH: Visceral obesity as a risk factor for colorectal neoplasm. J Gastroenterol Hepatol; 2008 Mar;23(3):411-7
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  • [Title] Visceral obesity as a risk factor for colorectal neoplasm.
  • BACKGROUND AND AIM: Obesity as a risk factor for colorectal neoplasm (CRN) is controversial.
  • The amount of visceral adipose tissue (VAT) and subcutaneous adipose tissue was measured by an abdominopelvic CT scan.
  • Waist circumference, metabolic syndrome, and fasting plasma glucose levels were not independent risk factors for CRN in the multivariate analysis.
  • [MeSH-major] Colonoscopy. Colorectal Neoplasms / etiology. Intra-Abdominal Fat / radiography. Mass Screening / methods. Obesity / complications. Tomography, X-Ray Computed


26. Katz AJ, Tholpady A, Tholpady SS, Shang H, Ogle RC: Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells. Stem Cells; 2005 Mar;23(3):412-23
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  • [Title] Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells.
  • Adult human subcutaneous adipose tissue contains cells with intriguing multilineage developmental plasticity, much like marrow-derived mesenchymal stem cells.
  • The study reported here used microarrays to evaluate over 170 genes relating to angiogenesis and extracellular matrix in undifferentiated, early-passage human adipose-derived adherent stromal (hADAS) cells isolated from three separate donors.
  • Finally, based on flow analysis and reverse transcription polymerase chain reaction studies, our results suggest that hADAS cells do not express several proteins that are implicated as markers of "stemness" in other stem cell populations, including telomerase, CD133, and the membrane transporter ABCG2.
  • [MeSH-major] Adipose Tissue / cytology. Antigens, Surface / analysis. Gene Expression Profiling. Stromal Cells / cytology
  • [MeSH-minor] ATP-Binding Cassette Transporters / genetics. Adult. Antigens, Differentiation / analysis. Cell Differentiation / physiology. Cells, Cultured. Flow Cytometry. Humans. Middle Aged. Neoplasm Proteins / genetics. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction. Telomerase / genetics. Transcription, Genetic / genetics

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  • (PMID = 15749936.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R21 DE 15023; United States / NHLBI NIH HHS / HL / R21 HL 72141
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / Antigens, Differentiation; 0 / Antigens, Surface; 0 / Neoplasm Proteins; EC 2.7.7.49 / Telomerase
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27. Arosarena O: Tissue engineering. Curr Opin Otolaryngol Head Neck Surg; 2005 Aug;13(4):233-41
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  • [Title] Tissue engineering.
  • PURPOSE OF REVIEW: Regenerative medicine holds promise for the restoration of tissues and organs damaged by wear, trauma, neoplasm, or congenital deformity.
  • Tissue engineering combines the disciplines of cell biology and biomedical engineering to effect the design and maturation of various tissues.
  • Despite progress in some areas of tissue regeneration, there has not been significant translation to clinical practice.
  • A discussion of the state of the art in the regeneration of skin, cartilage, bone, adipose tissue, and neural tissue is included.
  • RECENT FINDINGS: Differences between extracorporeal and in-vitro tissue engineering are discussed, as well as tissue engineering principles, including the use of bioactive scaffolds, progenitor cells and stem cells, the need for cellular and tissue patterning, microcirculation development, and the use of external stimuli for differentiation.
  • Much needs to be learned about progenitor cell biology, cell-cell interactions, cellular interactions with the extracellular matrix, and about the cues needed for differentiation of functional tissues.
  • SUMMARY: The current limitations in regenerative medicine techniques and the gaps in current knowledge of cellular biology and tissue development represent significant research opportunities in tissue engineering.
  • [MeSH-major] Regeneration. Tissue Engineering
  • [MeSH-minor] Biomedical Engineering. Cell Differentiation. Cell Transplantation / methods. Developmental Biology / methods. Genetic Therapy / methods. Growth Substances / therapeutic use. Humans. Stem Cells / cytology

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  • (PMID = 16012248.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Growth Substances
  • [Number-of-references] 125
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28. He M, Aisner S, Benevenia J, Patterson F, Aviv H, Hameed M: p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):51-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.
  • Atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive malignant mesenchymal neoplasm, resembling ordinary lipoma in many clinical aspects.
  • Fifty cases of lipomatous neoplasms, with cytogenetic results, from 45 patients were collected from the archives in Department of Pathology, University of Medicine and Dentistry of New Jersey/New Jersey Medical School during 1998 to 2006.

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  • (PMID = 18779733.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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29. Mamalakis G, Hatzis C, de Bree E, Sanidas E, Tsiftsis DD, Askoxylakis J, Daskalakis M, Tsibinos G, Kafatos A: Adipose tissue fatty acids in breast cancer patients versus healthy control women from Crete. Ann Nutr Metab; 2009;54(4):275-82
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  • [Title] Adipose tissue fatty acids in breast cancer patients versus healthy control women from Crete.
  • BACKGROUND: Few studies have implemented biomarkers of fatty acid intake in relation to breast cancer.
  • AIMS: To examine possible differences in adipose tissue fatty acid composition between breast cancer patients and healthy control women.
  • The relationship between tumor promotion and adipose tissue fatty acid synthesis was also investigated.
  • Histological tumor grading and breast cancer staging were assessed.
  • Fatty acids were determined by gas chromatography in gluteal adipose tissue.
  • RESULTS: Conditional logistic regression analysis controlling for potential confounders indicated that elevated adipose monounsaturated fatty acids and oleic acid are associated with reduced odds of breast cancer [OR (T2 vs. T1) 0.15; 95% CI 0.03-0.64, and OR (T2 vs. T1) 0.18; 95% CI 0.04-0.71, respectively].
  • Adipose myristic acid was associated with an increase in breast cancer risk [OR (T3 vs. T1) 5.66; 95% CI 1.3-23.9].
  • CONCLUSIONS: Adipose oleic acid is inversely related, whereas adipose myristic acid is positively related to breast cancer risk.
  • [MeSH-major] Breast Neoplasms / chemistry. Fatty Acids / analysis. Subcutaneous Fat / chemistry
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers / analysis. Buttocks. Case-Control Studies. Female. Greece. Humans. Middle Aged. Myristic Acid / analysis. Neoplasm Staging. Oleic Acid / analysis. Risk Factors. Statistics as Topic. Tumor Burden. Young Adult

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19641305.001).
  • [ISSN] 1421-9697
  • [Journal-full-title] Annals of nutrition & metabolism
  • [ISO-abbreviation] Ann. Nutr. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Fatty Acids; 0I3V7S25AW / Myristic Acid; 2UMI9U37CP / Oleic Acid
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30. Janke J, Engeli S, Gorzelniak K, Feldpausch M, Heintze U, Böhnke J, Wellner M, Herse F, Lassalle P, Luft FC, Sharma AM: Adipose tissue and circulating endothelial cell specific molecule-1 in human obesity. Horm Metab Res; 2006 Jan;38(1):28-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adipose tissue and circulating endothelial cell specific molecule-1 in human obesity.
  • This study investigates ESM-1 expression and regulation in human adipose tissue.
  • Subcutaneous abdominal adipose tissue was obtained from seventy postmenopausal women.
  • In vitro experiments were performed on adipocytes isolated from human mammary adipose tissue.
  • This inhibitory effect of insulin was attenuated by insulin resistance, as ESM-1 gene expression in subcutaneous adipose tissue was increased in obese, hyperinsulinemic women.
  • Five percent weight loss did not markedly change gene expression.
  • However, since ESM-1 adipocyte gene expression and circulating plasma levels are not correlated, other sources of ESM-1 may be more important.
  • Circulating ESM-1 levels are reduced in the overweight and obese, consistent with the notion that ESM-1 may play some role in obesity-associated vascular disease.
  • [MeSH-major] Adipocytes / metabolism. Gene Expression Regulation. Neoplasm Proteins / biosynthesis. Obesity / metabolism. Proteoglycans / biosynthesis. Subcutaneous Fat, Abdominal / metabolism

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  • (PMID = 16477537.001).
  • [ISSN] 0018-5043
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / ESM1 protein, human; 0 / Neoplasm Proteins; 0 / Proteoglycans
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31. Timper K, Seboek D, Eberhardt M, Linscheid P, Christ-Crain M, Keller U, Müller B, Zulewski H: Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells. Biochem Biophys Res Commun; 2006 Mar 24;341(4):1135-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells.
  • MSC from human bone marrow and adipose tissue represent very similar cell populations with comparable phenotypes.
  • Adipose tissue is abundant and easily accessible and could thus also harbor cells with the potential to differentiate in insulin producing cells.
  • We isolated human adipose tissue-derived MSC from four healthy donors.
  • [MeSH-major] Adipose Tissue / cytology. Glucagon / biosynthesis. Insulin / biosynthesis. Mesenchymal Stromal Cells / metabolism. Somatostatin / biosynthesis
  • [MeSH-minor] ATP-Binding Cassette Transporters / biosynthesis. Antigens, Thy-1 / biosynthesis. Cell Differentiation. Cells, Cultured. Homeodomain Proteins / biosynthesis. Humans. Intermediate Filament Proteins / biosynthesis. LIM-Homeodomain Proteins. Neoplasm Proteins / biosynthesis. Nerve Tissue Proteins / biosynthesis. Nestin. Proto-Oncogene Proteins c-kit / biosynthesis. Stem Cell Factor / biosynthesis. Transcription Factors

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  • (PMID = 16460677.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / Antigens, Thy-1; 0 / Homeodomain Proteins; 0 / Insulin; 0 / Intermediate Filament Proteins; 0 / LIM-Homeodomain Proteins; 0 / NES protein, human; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / Stem Cell Factor; 0 / Transcription Factors; 0 / insulin gene enhancer binding protein Isl-1; 51110-01-1 / Somatostatin; 9007-92-5 / Glucagon; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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32. Mariniello B, Ronconi V, Rilli S, Bernante P, Boscaro M, Mantero F, Giacchetti G: Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Eur J Endocrinol; 2006 Sep;155(3):435-41
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  • [Title] Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome.
  • OBJECTIVE: To evaluate the expression of 11beta-hydrxysteroid dehydrogenase type 1 (11beta-HSD1) in omental adipose tissue of patients with Cushing's syndrome and simple obesity, compared with normal weight controls.
  • DESIGN AND METHODS: We have performed a case-control study and studied omental adipose tissue from a total of 24 subjects (eight obese subjects, ten patients with Cushing's syndrome due to adrenal adenoma, and six normal weight controls).

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  • (PMID = 16914598.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Neoplasm; EC 1.1.1.146 / 11-beta-Hydroxysteroid Dehydrogenase Type 1
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33. Bandyopadhyay S, Basturk O, Coban I, Thirabanjasak D, Liang H, Altinel D, Adsay NV: Isolated solitary ducts (naked ducts) in adipose tissue: a specific but underappreciated finding of pancreatic adenocarcinoma and one of the potential reasons of understaging and high recurrence rate. Am J Surg Pathol; 2009 Mar;33(3):425-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated solitary ducts (naked ducts) in adipose tissue: a specific but underappreciated finding of pancreatic adenocarcinoma and one of the potential reasons of understaging and high recurrence rate.
  • We recently noted isolated solitary ductal units (ISDs) in adipose tissue to be a reliable indicator of adenocarcinoma.
  • ISD was defined as a solitary gland lying individually in adipose tissue, either directly abutting adipocytes or separated from them by only a thin rim of fibromuscular tissue.
  • ISD was detected in 50/105 (47.6%) of pancreatic resections for ductal adenocarcinoma, but not in any resections with chronic pancreatitis only (specificity 100%; sensitivity 47.6%).
  • ISDs were often located in histologic sections taken for the evaluation of the retroperitoneal margin and pancreatic-free surfaces where adipose tissue is more abundant.
  • In conclusion, ISD lying in adipose tissue unaccompanied by other elements, present in 47.6% of pancreatic resections when peripancreatic soft tissues away from the tumor are sampled, is a very specific finding for carcinoma that may be instrumental in the diagnosis and staging of carcinoma as well as margin evaluation.
  • [MeSH-major] Adipose Tissue / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Pancreatitis / pathology

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  • (PMID = 19092633.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. McQueen C, Montgomery E, Dufour B, Olney MS, Illei PB: Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol; 2010 Jan;17(1):38-41
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  • [Title] Giant hypopharyngeal atypical lipomatous tumor.
  • Microscopically, they display an admixture of fibrovascular and adipose tissue that is coated by unremarkable squamous mucosa.
  • Here, we report a case that had scattered hyperchromatic cells and lipoblasts within the adipose tissue component.
  • In other anatomic sites similar appearing lesions have been interpreted as pedunculated liposarcomas/atypical lipomatous tumors that are more prone to local recurrences than classic giant fibrovascular polyps.
  • To confirm our suspicion of liposarcomatous differentiation, we performed immunohistochemistry for MDM2 and p53, 2 markers that are known to be negative in benign lipomatous lesions and positive in well-differentiated liposarcomas/atypical lipomatous tumors.
  • The scattered atypical hyperchromatic cells and the lipoblasts both exhibited strong nuclear staining for both markers and supported the diagnosis of pedunculated giant hypopharyngeal atypical lipomatous tumor.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Liposarcoma / pathology
  • [MeSH-minor] Humans. Immunohistochemistry. Male. Middle Aged. Polyps / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20032637.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 51
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35. Browne TJ, Fletcher CD: Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology; 2006 Mar;48(4):453-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity.
  • AIMS: To describe 13 new cases of a rare soft tissue neoplasm currently known as haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL) and to further its characterization.
  • Grossly the lesions were fatty/gelatinous or lipoma-like.
  • Dissecting between adipocytic lobules were septa containing short spindle cells with streaming, swirling or honeycomb growth patterns.
  • CONCLUSIONS: So-called HFHLL, better termed haemosiderotic fibrolipomatous tumour, is a distinct lesion characterized by an admixture of fibroblastic spindle cells, mature adipocytes and haemosiderin pigmentation, shows a predilection for the distal extremities and quite often recurs locally.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16487368.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 9011-92-1 / Hemosiderin
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36. Witt PM, Christensen JH, Schmidt EB, Dethlefsen C, Tjønneland A, Overvad K, Ewertz M: Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark. Cancer Causes Control; 2009 Nov;20(9):1715-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark.
  • OBJECTIVE: The aim of this study was to investigate the association between the content of marine n-3 polyunsaturated fatty acids (PUFA) in adipose tissue, a biomarker for the long-term intake of seafood, and the subsequent development of breast cancer (BC).
  • DESIGN: We designed a case-cohort study based on a cohort of healthy Danish women, who in the 1990 s donated adipose tissue biopsies to a biobank in order to investigate the role of diet for the development of cancer and chronic disease.
  • During follow-up, incident cases of BC were identified through national registries, and the content of n-3 PUFA in adipose tissue was compared between cases and the cohort sample.
  • CONCLUSION: This study does not indicate any association between the content of total or individual marine n-3 PUFA in adipose tissue and development of BC.
  • [MeSH-major] Adipose Tissue / chemistry. Biomarkers, Tumor / analysis. Breast Neoplasms / chemistry. Fatty Acids, Omega-3 / analysis
  • [MeSH-minor] Aged. Case-Control Studies. Denmark. Female. Humans. Middle Aged. Neoplasm Staging. Risk Factors

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  • (PMID = 19711189.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fatty Acids, Omega-3
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37. Suster S, Morrison C: Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Histopathology; 2008 Feb;52(3):283-93
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  • [Title] Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue.
  • AIMS: To present eight cases of a distinctive morphological subtype of lipomatous tumour of soft tissue.
  • Four cases arose de novo and four cases presented as local recurrences of previously resected liposarcomas.
  • [MeSH-major] Liposarcoma / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. RNA-Binding Protein FUS / genetics. Soft Tissue Neoplasms / pathology. Transcription Factor CHOP / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Fatal Outcome. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Recurrence, Local. Sclerosis / pathology. Translocation, Genetic

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  • (PMID = 18269578.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Protein FUS; 0 / TLS-CHOP fusion protein, human; 147336-12-7 / Transcription Factor CHOP; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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38. Acar GO, Cansiz H, Acioğlu E, Yağiz C, Dervişoğlu S: Atypical lipomatous tumour of the head and neck region with dyspnea and dysphagia: a case report. Eur Arch Otorhinolaryngol; 2007 Aug;264(8):947-50
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  • [Title] Atypical lipomatous tumour of the head and neck region with dyspnea and dysphagia: a case report.
  • Liposarcoma is one of the most common soft tissue sarcomas in adults.
  • Atypical lipomatous tumour (ALT) rarely occurs in the head and neck region.
  • Histopathologic grade of these tumours affect prognosis of this disease.
  • In this article, a case of a huge ALT arising from the head and neck region and invading nearly entire left hemi-facial region is presented.
  • Clinical and histopathologic features and therapeutic approaches related to this tumour are discussed reviewing the literature.
  • [MeSH-major] Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / complications. Liposarcoma / complications
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 17361411.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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39. Fernandez-Flores A, Juanes F: Value of cytological imprints in the diagnosis of atypical lipomatous tumor. Diagn Cytopathol; 2005 Jan;32(1):51-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of cytological imprints in the diagnosis of atypical lipomatous tumor.
  • The diagnosis of atypical lipomatous tumor by biopsy, requires careful examination of several slides, in order to look for atypical cells.
  • We suggest that imprints of lipomatous tumors may play a complementary role in such a search, and report a case of a 74-yr-old woman with an atypical lipomatous tumor of the left thigh, in which imprints helped to make the diagnosis..
  • [MeSH-major] Cytodiagnosis / methods. Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15584038.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • We present a rare atypical lipomatous tumour with spindle cell features (synonym: well-differentiated spindle cell liposarcoma) arising on the left palm of a 54-year-old male patient.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • However, focally, atypia of adipocytic and stromal cells as well as scattered lipoblasts were noted, and immunohistochemical stainings showed focal overexpression of MDM 2 and CDK4.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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41. Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Nakaigawa N, Kishida T, Nagashima Y, Kubota Y: Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma. Clin Cancer Res; 2007 Jan 1;13(1):152-60
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  • [Title] Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma.
  • PURPOSE: We recently found that adipose differentiation-related protein (ADFP) is a potential diagnostic and prognostic biomarker for clear cell subtype renal cell carcinoma (RCC).
  • ADFP expression levels in the primary tumors and in 18 metastases were measured by real-time quantitative PCR.
  • The clinicopathologic and prognostic data were collected, as well as the von Hippel-Lindau disease (VHL) gene alteration status in selected cases.
  • RESULTS: ADFP expression was apparently high in cases without a symptomatic presentation, as well as in cases of low-stage, low-grade, or VHL alteration-positive clear cell RCC, whereas it was down-regulated in undifferentiated tumors with a spindle/pleomorphic component or metastatic lesions.
  • Further Cox multivariate analyses combined with the split-sample validation method showed that ADFP expression still remains an independent predictor for cancer-specific survival in all tumor stages and in advanced metastatic cases, whereas the predictive value of ADFP expression for cancer recurrence is rather weak.
  • CONCLUSIONS: The ADFP expression may represent the tumor differentiation status, and the detection of the expression levels provides useful prognostic information for cancer-specific survival in patients with clear cell RCC.
  • [MeSH-major] Adipose Tissue / metabolism. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / mortality. Gene Expression Regulation, Neoplastic. Kidney Neoplasms / metabolism. Kidney Neoplasms / mortality. Membrane Proteins / biosynthesis. Membrane Proteins / physiology. Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Differentiation. Disease Progression. Disease-Free Survival. Humans. Middle Aged. Multivariate Analysis. Neoplasm Metastasis. Prognosis. Proportional Hazards Models


42. Lin TM, Chang HW, Wang KH, Kao AP, Chang CC, Wen CH, Lai CS, Lin SD: Isolation and identification of mesenchymal stem cells from human lipoma tissue. Biochem Biophys Res Commun; 2007 Oct 5;361(4):883-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolation and identification of mesenchymal stem cells from human lipoma tissue.
  • Lipoma is a benign neoplasm of normal fat cells that appears as a soft, movable swelling, often with a slight yellowish coloration.
  • Human mesenchymal stem cells (MSCs) that have been isolated from bone marrow, blood, and other adult tissues including adipose tissue have the potential to be useful candidates for therapy.
  • No literature had reported about stem cells from lipoma tissue.
  • Cells produced in early cultures display characteristics similar to those previously reported for multipotential stem cells, including a high frequency of anchorage-independent growth in soft agar and a lack of gap junctional intercellular communication in cell types with serpiginous morphology.

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  • (PMID = 17679141.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Evans HL: Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol; 2007 Jan;31(1):1-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years.
  • Sixty-one cases of neoplasms composed wholly or in part of atypical lipomatous tumor were reviewed.
  • The cases were divided into 4 groups based on the findings in the initial excision specimen: conventional atypical lipomatous tumor (n=15), cellular atypical lipomatous tumor (n=21), dedifferentiated liposarcoma (n=24), and atypical lipomatous tumor with a pleomorphic liposarcoma-like component (n=1).
  • The term "cellular atypical lipomatous tumor" was applied to atypical lipomatous tumors having areas of increased cellularity that when non-lipogenic lacked the 5 mitotic figures per 10 high-power fields (maximal rate) required for a dedifferentiated component and when lipogenic fell short of being truly pleomorphic liposarcoma-like.
  • The most important prognostic factor was tumor location, as none of the 12 patients with a subcutaneous or intramuscular neoplasm died of tumor.
  • Among the 49 patients with neoplasms of central body sites (mostly retroperitoneum), those with dedifferentiated liposarcoma had significantly shorter survival (median 77 mo) than those with cellular (median 142 mo) or conventional (median 209 mo) atypical lipomatous tumor, whereas there was no statistically significant difference between the latter 2 categories.
  • Patients with atypical lipomatous tumor (either cellular or conventional) in central body sites had significantly shorter survival if the tumor transformed into dedifferentiated liposarcoma in recurrence, and, conversely, those with central body site dedifferentiated liposarcoma had significantly longer survival if it recurred as atypical lipomatous tumor.
  • [MeSH-major] Liposarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Follow-Up Studies. Humans. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • (PMID = 17197914.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Maruyama K, Motoyama S, Okuyama M, Sasaki K, Sato Y, Hayashi K, Nanjo H, Ogawa J: Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus. Surg Today; 2007;37(2):173-5
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  • [Title] Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus.
  • We describe how we removed a giant pedunculated atypical lipomatous tumor, arising in the cervical to upper thoracic esophagus and occupying a region extending from the cervical to the middle thoracic esophagus, through a cervical esophagotomy without thoracotomy or laparotomy.
  • We suggest that if the base of the tumor is located in the cervical portion of the esophagus, and if the tumor is not aggressive, the cervical approach is best, irrespective of the size of the tumor.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagectomy / methods. Liposarcoma / surgery. Neck / surgery. Thoracotomy / methods

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  • (PMID = 17243042.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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45. Stojsić Z, Brasanac D, Bacetić D, Janković R, Drndarević N: Soft tissue myoepithelial carcinoma. Vojnosanit Pregl; 2006 Jun;63(6):611-4
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  • [Title] Soft tissue myoepithelial carcinoma.
  • BACKGROUND: Myoepitheliomas are tumors composed predominantly or exclusively of myoepithelial cells, usually arising in salivary glands.
  • Cutaneous/soft tissue localization is very rare, especially for the malignant myoepitheliomas.
  • CASE REPORT: We presented a case of myoepithelial carcinoma involving subcutaneous adipose tissue of the left forearm in a woman aged 62 years.
  • The tumor was composed of epithelioid and hyaline cell types, arranged in diffuse sheets, nests and loose clusters within hyalinized and myxoid matrix.
  • The neoplasm displayed high-grade cytologic atypia with some cells having pleomorphic, hyperchromatic nuclei, and others showing vesicular nuclei, large nucleoli with scattered bizarre giant cells.
  • High mean mitotic count of 7 mitoses/10 high power filds and extensive necrosis favoured the diagnosis of malignancy.
  • CONCLUSION: Considering the subcutaneous localization, myoepithelial immunophenotype and high-grade cytologic atypia the neoplasm was classified as a soft-tissue myoepithelial carcinoma.
  • [MeSH-major] Myoepithelioma / pathology. Soft Tissue Neoplasms / pathology. Subcutaneous Fat / pathology

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  • (PMID = 16796029.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Serbia and Montenegro
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46. Pinilla S, Alt E, Abdul Khalek FJ, Jotzu C, Muehlberg F, Beckmann C, Song YH: Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion. Cancer Lett; 2009 Oct 18;284(1):80-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion.
  • In the present study, we investigated whether human adipose tissue derived stem cells (hASCs) could enhance tumor invasion and whether these hASCs could be a potential source of CCL5.
  • We conclude that CCL5 plays a crucial role for tumor invasion in the interplay of tissue resident stem cells from the fat tissue and breast cancer cells.
  • [MeSH-major] Adipose Tissue / pathology. Breast Neoplasms / pathology. Chemokine CCL5 / biosynthesis. Stem Cells / physiology
  • [MeSH-minor] Cell Line, Tumor. Coculture Techniques. Collagen. Drug Combinations. Humans. Laminin. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness. Proteoglycans

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  • (PMID = 19427114.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / CCL5 protein, human; 0 / Chemokine CCL5; 0 / Drug Combinations; 0 / Laminin; 0 / Proteoglycans; 119978-18-6 / matrigel; 9007-34-5 / Collagen; EC 3.4.24.35 / Matrix Metalloproteinase 9
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47. Kuhnen C, Mentzel T, Lehnhardt M, Homann HH, Sciot R, Debiec-Rychter M: [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition]. Pathologe; 2010 Mar;31(2):129-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition].
  • [Transliterated title] Lipom und atypischer lipomatöser Tumor innerhalb einer Neoplasie: Hinweis für einen kontinuierlichen Ubergang.
  • The case of a lipomatous tumor with a predominant lipoma component and transition to an atypical lipomatous tumor is presented.
  • A deep-seated soft tissue tumor of the right thigh with a maximum size of 14 cm was resected in a 70-year-old female patient.
  • In the remaining portion (approximately 20%) histopathology showed an atypical lipomatous tumor (ALT, lipoma-like subtype).
  • Interphase dual-color fluorescence in situ hybridization showed no amplification of the MDM 2 gene and rarely CDK4 gene amplification within the lipoma component, but high level amplification of MDM 2/CDK4 gene in the ALT area, further supporting the morphologically based diagnosis of a lipomatous tumor including areas of a true lipoma and ALT.
  • This case underlines the concept of a continuous stepwise development of lipomatous soft tissue tumors from benign to malignant counterparts as a biological continuum.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. In Situ Hybridization, Fluorescence. Proto-Oncogene Proteins c-mdm2 / genetics. Thigh

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  • (PMID = 20063101.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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48. Titiz A, Yilmaz YF, Ceyhan S, Unal T: Atypical lipomatous tumor in the submental region. J Craniofac Surg; 2008 Nov;19(6):1558-60
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  • [Title] Atypical lipomatous tumor in the submental region.
  • A 54-year-old male patient presented to our outpatient clinic complaining of a mass under his chin, which appeared nearly 1 year earlier.
  • Pathologic diagnosis was atypical lipomatous tumor.
  • Atypical lipomatous tumors/well-differentiated liposarcomas are rarely reported in the head and neck.
  • We review the clinical and management features of atypical lipomatous tumors.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Liposarcoma / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Cell Nucleus / ultrastructure. Contrast Media. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-mdm2 / analysis. S100 Proteins / analysis. Stromal Cells / pathology. Tomography, X-Ray Computed

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  • (PMID = 19098551.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Contrast Media; 0 / S100 Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 13
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49. Doğan R, Kara M, Yazicioğlu A, Onder S: Giant atypical lipomatous tumor of the mediastinum. Tuberk Toraks; 2008;56(1):100-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant atypical lipomatous tumor of the mediastinum.
  • Atypical lipomatous tumors, so-called well differentiated liposarcomas are the intermediate or locally aggressive form of adipocytic tumors.
  • Mediastinum is an uncommon localization for these tumors and they have a potential risk of recurrence following excision.
  • We herein report a case with a giant atypical lipomatous tumor located at the mediastinum that was surgically excised.
  • [MeSH-major] Liposarcoma / surgery. Mediastinal Neoplasms / surgery

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  • (PMID = 18330763.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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50. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Moritani N, Yamada T, Mizobuchi K, Wakimoto M, Ikeya Y, Matsumura T, Mishima K, Iida S: Atypical lipomatous tumor of the tongue: report of a case. Acta Med Okayama; 2010 Aug;64(4):257-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumor of the tongue: report of a case.
  • The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL).
  • This tumor occurs very rarely in the tongue.
  • Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites.
  • A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue.
  • Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless.
  • We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia.
  • Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia.
  • [MeSH-major] Liposarcoma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Lipoma / diagnosis. Lipoma / pathology. Male. Prognosis. Treatment Outcome

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  • (PMID = 20802543.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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52. Miyakura T, Irisawa R, Miyamoto M, Iwaya K, Yamamoto T, Tsuboi R: An atypical case of atypical lipomatous tumor. Am J Dermatopathol; 2008 Dec;30(6):590-2
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  • [Title] An atypical case of atypical lipomatous tumor.
  • Immunohistochemically, some of the tumor cells were positive for p53 and MDM2.
  • Histologically, the atypical lipomatous tumor, lipoblastoma, spindle cell lipoma, pleomorphic liposarcoma, and hibernoma comprised the list of possible, differential diagnoses.
  • We considered our case to be a variant of atypical lipomatous tumor, although it did not correspond to any of the 4 atypical lipomatous tumor subgroups.
  • [MeSH-major] Adipocytes / pathology. Liposarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Middle Aged. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19033936.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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53. Patel J, Deb R, Speake W, Macculloch TA: Primary small bowel liposarcoma (atypical lipomatous tumour) with myogenic differentiation. Sarcoma; 2010;2010

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  • [Title] Primary small bowel liposarcoma (atypical lipomatous tumour) with myogenic differentiation.
  • Primary small intestinal liposarcomas originating in the small bowel are uncommon with a generally poor prognosis due to the advanced stage at the time of diagnosis.
  • The current case is unusual as the tumour seemingly originated from the bowel and the well-differentiated component was seen extensively infiltrating the bowel wall including the small bowel submucosa.

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  • [Cites] Am J Surg Pathol. 1979 Dec;3(6):507-23 [534388.001]
  • [Cites] Am J Surg Pathol. 1994 Dec;18(12):1213-23 [7977944.001]
  • [Cites] World J Gastroenterol. 2008 Oct 14;14(38):5927-9 [18855997.001]
  • [Cites] Minerva Gastroenterol Dietol. 2000 Jun;46(2):119-22 [16498358.001]
  • [Cites] Am J Surg Pathol. 1997 Mar;21(3):271-81 [9060596.001]
  • (PMID = 20706648.001).
  • [ISSN] 1369-1643
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2913843
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54. Heiba SI, Bernik S, Raphael B, Sandella N, Cholewinski W, Klein P: The distinctive role of positron emission tomography/computed tomography in breast carcinoma with brown adipose tissue 2-fluoro-2-deoxy-d-glucose uptake. Breast J; 2005 Nov-Dec;11(6):457-61
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The distinctive role of positron emission tomography/computed tomography in breast carcinoma with brown adipose tissue 2-fluoro-2-deoxy-d-glucose uptake.
  • The precise anatomic localization of FDG uptake with CT in a PET/CT scan of a patient with known breast carcinoma helped identify a contralateral breast tumor with axillary lymph node metastasis despite the presence of extensive physiologic brown fat FDG uptake.
  • Accordingly, the patient received appropriate surgical management and pathologic confirmation of the disease.
  • [MeSH-major] Breast Neoplasms / radiography. Breast Neoplasms / radionuclide imaging. Carcinoma / radiography. Carcinoma / radionuclide imaging. Neoplasm Recurrence, Local / radiography. Neoplasm Recurrence, Local / radionuclide imaging
  • [MeSH-minor] Adipose Tissue, Brown / chemistry. Adult. Female. Fluorodeoxyglucose F18 / pharmacokinetics. Humans. Lymphatic Metastasis / radiography. Lymphatic Metastasis / radionuclide imaging. Neoplasm Staging. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 16297092.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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55. Kaneko G, Nishimoto K, Ogata K, Uchida A: [A case of lipomatous tumor arising from the paratesticular lesion]. Hinyokika Kiyo; 2009 Nov;55(11):725-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of lipomatous tumor arising from the paratesticular lesion].
  • We encountered a case of lipomatous tumor in the left scrotum, which was clinically and radiologically quite similar to an inguinal hernia.
  • A 75-year-old male patient visited a nearby hospital complaining of a painless left scrotal swelling.
  • The tumor marker levels were within the normal range.
  • A preoperative diagnosis of inguinal hernia containing the omentum was made.
  • Microscopically, most of the tumor consisted of mature adipocytes, some of which had different cellular sizes.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Lipoma / pathology. Scrotum

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  • (PMID = 19946194.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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56. Yao M, Tabuchi H, Nagashima Y, Baba M, Nakaigawa N, Ishiguro H, Hamada K, Inayama Y, Kishida T, Hattori K, Yamada-Okabe H, Kubota Y: Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J Pathol; 2005 Feb;205(3):377-87
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma.
  • The gene expression profiles of 33 renal cell carcinomas (RCCs) and nine normal kidney samples were examined using high-density oligonucleotide microarrays in an attempt to identify biomolecular markers for the diagnosis of tumour subtypes and also for prediction of prognosis.
  • Hierarchical clustering demonstrated that clear-cell RCC, chromophobe RCC, and normal kidney tissue showed distinctive gene expression profiles.
  • The mean expression levels of 149 of 12 500 genes were more than three times higher in clear-cell RCC than in chromophobe RCC and normal kidney tissue.
  • Among the genes whose expression was upregulated in clear-cell RCC, adipose differentiation-related protein (ADFP) and nicotinamide N-methyltransferase (NNMT) were selected for further analysis.
  • Consistent with the results of the microarray, increased levels of ADFP and NNMT mRNA were found more frequently in clear-cell RCCs than in other non-clear-cell tumour subtypes using real-time quantitative PCR.
  • Immunohistochemistry for ADFP showed strong and unique tumour cell staining patterns in the majority of clear-cell RCCs.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Cluster Analysis. Female. Gene Expression Profiling / methods. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis / methods. Prognosis. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Survival Analysis. Up-Regulation


57. Kalaci A, Karazincir S, Yanat AN: Long-standing Morel-Lavallée lesion of the thigh simulating a neoplasm. Clin Imaging; 2007 Jul-Aug;31(4):287-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-standing Morel-Lavallée lesion of the thigh simulating a neoplasm.
  • We report on the case of a 56-year-old man in whom a Morel-Lavallée lesion developed in the thigh.
  • We also discuss both the difficulty in making a differential diagnosis for and the treatment of this lesion.
  • [MeSH-major] Hematoma / diagnosis. Soft Tissue Neoplasms / diagnosis. Thigh / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Diagnosis, Differential. Exudates and Transudates. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17599627.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Milam MR, Abaid L, dos Reis R, Frumovitz M, Gehrig PA, Livasy C, Broaddus RR, Ramirez PT: Microscopic evaluation of lymph-node-bearing tissue in early-stage cervical cancer: a dual-institution review. Ann Surg Oncol; 2010 Apr;17(4):1106-10
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microscopic evaluation of lymph-node-bearing tissue in early-stage cervical cancer: a dual-institution review.
  • At MDACC lymph nodes were grossly dissected from submitted adipose tissue surgical specimens and then microscopically examined.
  • At UNC, grossly detected lymph nodes and the remaining adipose tissue were microscopically examined.
  • CONCLUSION: The UNC method of microscopically examining the entire adipose tissue sample may be associated with higher nodal count at open radical hysterectomy.
  • Higher nodal count, however, may not translate into increased identification of nodal metastases.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Adenosquamous / secondary. Carcinoma, Squamous Cell / secondary. Lymph Nodes / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Hysterectomy. Lymphatic Metastasis. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Treatment Outcome. Young Adult

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  • (PMID = 20039215.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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59. Song M, Seo SH, Jung DS, Ko HC, Kwon KS, Kim MB: Angiomyxolipoma (vascular myxolipoma) of subcutaneous tissue. Ann Dermatol; 2009 May;21(2):189-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiomyxolipoma (vascular myxolipoma) of subcutaneous tissue.
  • Lipoma is the most common neoplasm of mesenchyme, and several subtypes have been described that vary according to their location and the presence of other tissue elements.
  • Angiomyxolipoma is a very rare variant that consists of an admixture of adipose and myxoid elements with numerous vascular structures.
  • Here the case of a 69-year-old male is described who presented with a solitary asymptomatic mass on the left iliac crest.
  • The histopathologic findings showed alternating nests of myxoid and adipose tissue containing dilated blood vessels, which was consistent with angiomyxolipoma.

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  • [Cites] Dermatol Surg. 2007 Apr;33(4):508-9 [17430390.001]
  • [Cites] J Cutan Pathol. 2005 May;32(5):379-82 [15811126.001]
  • [Cites] Histopathology. 1999 Feb;34(2):180-1 [10064402.001]
  • [Cites] Int J Gynecol Pathol. 1997 Oct;16(4):325-34 [9421071.001]
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  • [Cites] Am J Dermatopathol. 2004 Jun;26(3):222-4 [15166511.001]
  • [Cites] Hum Pathol. 2004 May;35(5):612-21 [15138937.001]
  • [Cites] Virchows Arch. 2001 Jan;438(1):66-9 [11213837.001]
  • (PMID = 20523784.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2861211
  • [Keywords] NOTNLM ; Angiomyxolipoma
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60. Argilés JM, Fontes-Oliveira CC, Fuster G, Ametller E, Figueras M, Olivan M, Lopez-Soriano FJ, Qu X, Demuth J, Stevens P, Varbanov A, Wang F, Isfort RJ, Busquets S: Patterns of gene expression in muscle and fat in tumor-bearing rats: effects of CRF2R agonist on cachexia. Muscle Nerve; 2010 Dec;42(6):936-49

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patterns of gene expression in muscle and fat in tumor-bearing rats: effects of CRF2R agonist on cachexia.
  • The hypothesis we tested was that administering corticotropin-releasing factor receptor agonists preserves muscle mass during cancer that is related to changes in tissue gene expression. cDNA microarrays were used to compare mRNAs from muscle and adipose tissues of non-treated and agonist-treated tumor-bearing rats.
  • In muscle of non-tumor-bearing agonist-treated animals we observed decreased expression of genes associated with fatty acid uptake and esterification.
  • In tumor-bearing animals, CRF2R agonist administration produced decreased mRNA content of the atrogene lipin-1.
  • In white adipose tissue, agonist treatment of non-tumor-bearing animals induced genes typically related to muscle structure and function.
  • In addition, agonist treatment changed the gene pattern of adipose tissue to render it similar to that of skeletal muscle; thus, treatment with this agonist alters the gene pattern to what could be called "muscularization of white adipose tissue. "
  • [MeSH-major] Adipose Tissue / metabolism. Cachexia / metabolism. Corticotropin-Releasing Hormone / pharmacology. Muscle, Skeletal / metabolism. Receptors, Corticotropin-Releasing Hormone / agonists
  • [MeSH-minor] Analysis of Variance. Animals. Gene Expression. Male. Neoplasm Transplantation. Nuclear Proteins / genetics. Nuclear Proteins / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rats. Rats, Wistar. Reverse Transcriptase Polymerase Chain Reaction. Tissue Array Analysis

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  • (PMID = 21104868.001).
  • [ISSN] 1097-4598
  • [Journal-full-title] Muscle & nerve
  • [ISO-abbreviation] Muscle Nerve
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRF receptor type 2; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Receptors, Corticotropin-Releasing Hormone; 0 / lipin-1 protein, rat; 9015-71-8 / Corticotropin-Releasing Hormone
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61. Agrawal MK, Thakur DS, Somashekar U, Chandrakar SK, Sharma D: Mesopancreas: myth or reality? JOP; 2010;11(3):230-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Loose areolar tissue, adipose tissue, peripheral nerve, nerve plexus, lymphatic and capillaries were found in the retropancreatic tissue, extending from the head, neck and uncinate process of pancreas to the aorto-caval groove but no fibrous sheath or fascia was found around these structures.
  • [MeSH-major] Fascia / anatomy & histology. Pancreas / anatomy & histology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / anatomy & histology. Adult. Cadaver. Celiac Plexus / anatomy & histology. Connective Tissue / anatomy & histology. Dissection. Duodenum / anatomy & histology. Gallbladder / anatomy & histology. Humans. Lymphatic System / anatomy & histology. Neoplasm Invasiveness / pathology. Portal Vein / anatomy & histology. Splanchnic Circulation. Vena Cava, Inferior / anatomy & histology

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  • (PMID = 20442517.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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62. Dietrich D, Schuster M, Lesche R, Haedicke W, Kristiansen G: [Multiplexed methylation analysis--a new technology to analyse the methylation pattern of laser microdissected cells of normal breast tissue, DCIS and invasive ductal carcinoma of the breast]. Verh Dtsch Ges Pathol; 2007;91:197-207
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiplexed methylation analysis--a new technology to analyse the methylation pattern of laser microdissected cells of normal breast tissue, DCIS and invasive ductal carcinoma of the breast].
  • AIMS: DNA methylation has been shown to play an important role in breast cancer pathogenesis, but up until now it is not clear how the tissue components contribute to the overall methylation of the sample, because microdissection does not provide sufficient material for most standard methylation assays.
  • METHODS: We developed a technology to analyse several methylation markers in a limited number of cells dissected from tissue sections.
  • The microdissected samples were from the invasive part, the intraductal part, the stroma, tumor infiltrating lymphocytes, chest wall muscle, adipose tissue and healthy ducts.
  • In all analysed patients PITX2 and RASSF1A were highly methylated in invasive and intraductal carcinoma cells compared to other tissue components.
  • PITX2 showed some methylation in normal adjacent breast tissue.
  • The methylation of the individual markers varied little within one tissue type and between blocks.
  • CONCLUSIONS: This technology is a powerful tool to analyse the methylation of multiple markers in different microdissected tissue components.
  • Methylation patterns may differ significantly between different markers and tissue components.
  • [MeSH-major] Breast / cytology. Breast Neoplasms / genetics. Breast Neoplasms / pathology. DNA Methylation. DNA, Neoplasm / genetics

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  • (PMID = 18314615.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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63. Jensen V, Witte MH, Latifi R: Massive localized lipolymphedema pseudotumor in a morbidly obese patient. Lymphology; 2006 Dec;39(4):181-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a 31 year old man with a massive localized tumor-like lipolymphedema, a puzzling entity that afflicts the morbidly obese.
  • After en bloc resection of the 28.2 kg edematous mass, no evidence of neoplasm was found, only prominent lymphatic vessel dilation and edema with large quantities of unremarkable adipose and connective tissue.
  • [MeSH-major] Liposarcoma / pathology. Lymphedema / diagnosis. Obesity, Morbid / complications
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Humans. Male. Thigh

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  • (PMID = 17319630.001).
  • [ISSN] 0024-7766
  • [Journal-full-title] Lymphology
  • [ISO-abbreviation] Lymphology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Muehlberg FL, Song YH, Krohn A, Pinilla SP, Droll LH, Leng X, Seidensticker M, Ricke J, Altman AM, Devarajan E, Liu W, Arlinghaus RB, Alt EU: Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis; 2009 Apr;30(4):589-97
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tissue-resident stem cells promote breast cancer growth and metastasis.
  • Mesenchymal stem cells derived from bone marrow have recently been described to localize to breast carcinomas and to integrate into the tumor-associated stroma.
  • In the present study, we investigated whether adipose tissue-derived stem cells (ASCs) could play a role in tumor growth and invasion.
  • Compared with bone marrow-derived cells, ASCs as tissue-resident stem cells are locally adjacent to breast cancer cells and may interact with tumor cells directly.
  • The tumor-promoting effect of ASCs was abolished by knockdown of the chemokine C-X-C receptor 4 in 4T1 tumor cells.
  • We demonstrated that ASCs home to tumor site and promote tumor growth not only when co-injected locally but also when injected intravenously.
  • Furthermore, we demonstrated that ASCs incorporate into tumor vessels and differentiate into endothelial cells.
  • The tumor-promoting effect of tissue-resident stem cells was also tested and validated using a human breast cancer line MDA-MB-231 cells and human adipose tissue-derived stem cells.
  • Our findings indicate that the interaction of local tissue-resident stem cells with tumor stem cells plays an important role in tumor growth and metastasis.
  • [MeSH-major] Lung Neoplasms / secondary. Mammary Neoplasms, Animal / pathology. Neoplastic Stem Cells / metabolism
  • [MeSH-minor] Adipose Tissue / metabolism. Adipose Tissue / pathology. Animals. Blotting, Western. Cell Movement. Chemokine CXCL12 / metabolism. Enzyme-Linked Immunosorbent Assay. Flow Cytometry. Immunoprecipitation. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Invasiveness. Neovascularization, Pathologic. Receptors, CXCR4 / antagonists & inhibitors. Receptors, CXCR4 / genetics. Receptors, CXCR4 / metabolism. Spheroids, Cellular. Stromal Cells / cytology. Stromal Cells / metabolism. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 19181699.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chemokine CXCL12; 0 / Receptors, CXCR4; 0 / Vascular Endothelial Growth Factor A
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65. Gokhale U, Pillai GR, Varghese PV, Samarsinghe D: Chondroid lipoma: a case report. Oman Med J; 2008 Apr;23(2):116-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid lipoma is a unique, uncommon benign lipomatous tumour.
  • We report such a neoplasm with brief a review of literature.

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  • (PMID = 22379550.001).
  • [ISSN] 1999-768X
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3282416
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66. Yalniz E, Alicioglu B, Oz Puyan F: Hibernoma: a benign lipomatous tumor mimicking liposarcoma. J BUON; 2008 Jan-Mar;13(1):127-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hibernoma: a benign lipomatous tumor mimicking liposarcoma.
  • Hibernoma is a rare, benign, slow-growing soft tissue tumor.
  • Due to its rich vascularity and magnetic resonance appearance, this tumor may mimic a liposarcoma before tissue diagnosis.
  • Malignant potential has not been demonstrated.
  • The clinical presentation, radiographic and histopathologic features of this rare benign soft tissue tumor are presented.
  • This tumor is clinically important because it is indistinguishable from malignant lesions.
  • [MeSH-major] Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18404800.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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67. Evers B, Speksnijder EN, Schut E, Ciampricotti M, Smalley MJ, Derksen PW, Jonkers J, de Visser KE: A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis. J Pathol; 2010 Jan;220(1):34-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis.
  • Cre/loxP-based conditional mouse models of breast cancer present unique opportunities to study sporadic tumour formation and progression in a controlled setting.
  • Moreover, conditional mouse tumour models do not permit independent manipulation of tumour cell-intrinsic and -extrinsic factors.
  • Although the latter can be achieved by cleared fat-pad transplantation of mouse mammary epithelial cells (MMECs) from tumour suppressor gene (TSG) knockouts into wild-type or mutant recipients, this procedure is not possible for mutations that cause embryonic lethality or preclude mammary gland development.
  • Tumour formation in the recipients mimicked tumour latency, spectrum, morphology, immunophenotype, and metastatic characteristics of the original mammary tumour model.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Mammary Glands, Animal / transplantation. Mammary Neoplasms, Experimental / pathology
  • [MeSH-minor] Adipose Tissue / transplantation. Animals. Cadherins / metabolism. Epithelial Cells / transplantation. Female. Keratin-8 / metabolism. Mice. Mice, Knockout. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Proteins / metabolism. Stochastic Processes. Vimentin / metabolism

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  • (PMID = 19927317.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Worldwide Cancer Research / / AICR/ 07-0585
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Keratin-8; 0 / Neoplasm Proteins; 0 / Vimentin
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68. Al-Momani HM: Recurrent maturing perineal lipoblastoma. Saudi Med J; 2005 Nov;26(11):1815-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma is a rare benign neoplasm of fetal adipose tissue that we see mostly in infants and young children less than 3 years of age.
  • We report a case of a recurrent perineal lipoblastoma in a 2.5-year-old boy, which showed maturation of the lipoblasts as compared to the primary tumor.
  • [MeSH-major] Lipoma / pathology. Lipoma / surgery. Neoplasms, Adipose Tissue / pathology. Neoplasms, Adipose Tissue / surgery

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  • (PMID = 16311674.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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69. Futagami A, Aoki M, Kawana S: A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue. Leuk Lymphoma; 2005 May;46(5):785-8
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  • [Title] A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue.
  • Histologically, the lesion showed a diffuse and dense infiltration of atypical lymphocytes extending from the superficial dermis to the subcutaneous tissue.
  • Severe lobular panniculitis, composed of small- and medium-sized atypical lymphocytes and large normal histiocytes, was observed in the subcutaneous adipose tissue.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / diagnosis. Neoplasm Regression, Spontaneous. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Blotting, Southern. Diagnosis, Differential. Humans. Immunohistochemistry. Immunophenotyping. Male. Skin / pathology. Subcutaneous Tissue / pathology

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  • (PMID = 16019520.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. Tazoe J, Okuyama C, Iehara T, Hosoi H, Nishimura T: Unusual fatty metamorphosis observed in diffuse liver metastases of stage 4S neuroblastoma. Pediatr Radiol; 2010 May;40(5):777-80
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  • [Title] Unusual fatty metamorphosis observed in diffuse liver metastases of stage 4S neuroblastoma.
  • We report a case of stage 4S neuroblastoma in which CT showed diffuse liver metastases containing a geographical fatty area in the periportal region.
  • MRI showed this abnormality to correspond to an area with an unusual pattern of fatty change. (123)I-metaiodobenzylguanidine (MIBG) scintigraphy demonstrated increased accumulation throughout the liver, except for the region showing fatty change.
  • To the best of our knowledge, this is the first report of liver metastases from neuroblastoma with geographical fatty infiltration.
  • [MeSH-major] Adipose Tissue / pathology. Adipose Tissue / radionuclide imaging. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Neuroblastoma / diagnosis. Neuroblastoma / secondary
  • [MeSH-minor] Female. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Staging

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  • (PMID = 20180113.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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71. Cho HJ, Kim SJ, Ha US, Hong SH, Kim JC, Choi YJ, Hwang TK: Prognostic value of capsular invasion for localized clear-cell renal cell carcinoma. Eur Urol; 2009 Dec;56(6):1006-12
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  • We analyzed clinical (presentation and body mass index [BMI]) and pathologic (tumor size, Fuhrman nuclear grade, collecting system invasion, microvascular invasion, and capsular involvement) parameters.
  • Capsular invasion had a statistically significant association with age, symptomatic presentation, tumor diameter, pathologic stage, collecting system invasion, and microvascular invasion.
  • The 5-yr RFS and CSS rates for tumors with capsular invasion were significantly lower compared with rates for tumors without invasion (77.7% vs 92.3% and 85.5% vs 95.7%, respectively; p=0.0004).
  • Multivariate analysis showed that BMI (hazard ratio [HR]=0.19), stage (HR=2.45), and capsular invasion (HR=3.36) were independent prognostic factors of disease recurrence.
  • With respect to CSS, BMI (HR=0.20), tumor size (HR=1.13), and capsular invasion (HR=4.03) were the factors related to death.
  • [MeSH-major] Adipose Tissue / pathology. Carcinoma, Renal Cell / mortality. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / mortality. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Fascia / pathology. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / mortality. Neoplasm Staging / mortality. Predictive Value of Tests. Prognosis. Proportional Hazards Models


72. Mukai M, Nakamura M, Kishima K, Ninomiya H, Nomura N, Sato H, Kato N, Machida T, Nakasaki H, Makuuchi H: Local recurrence and occult neoplastic cells in the extranodal fat of dissected lymph nodes in patients with curatively resected primary colorectal cancer. Oncol Rep; 2007 Jun;17(6):1365-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adipose Tissue / pathology. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Lymph Nodes / pathology. Neoplasm Recurrence, Local / epidemiology

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  • (PMID = 17487392.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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73. Tan D, Kraybill W, Cheney RT, Khoury T: Retiform hemangioendothelioma: a case report and review of the literature. J Cutan Pathol; 2005 Oct;32(9):634-7
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  • BACKGROUND: Retiform hemangioendothelioma (RH) is a rare, recently described vascular neoplasm of low malignant potential.
  • METHODS: We report a case of RH of the foot of a 19-year-old white female.
  • Histologically, the tumor grew as numerous elongated vessels resembling the shape of rete testis with involvement of the skin adnexal structures and subcutaneous adipose tissue.
  • [MeSH-major] Hemangioendothelioma / pathology. Skin Neoplasms / pathology

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  • (PMID = 16176302.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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74. Huang GS, Chang WC, Lee HS, Taylor JA, Cheng TY, Chen CY: Merkel cell carcinoma arising from the subcutaneous fat of the arm with intact skin. Dermatol Surg; 2005 Jun;31(6):717-9
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  • BACKGROUND: Merkel cell carcinoma is a rare malignant neuroendocrine neoplasm characteristically arising from the dermis of sunlight-exposed skin.
  • RESULTS: Histopathologic examination confirmed the diagnosis of Merkel cell carcinoma with local lymphatic metastasis, and the lesion was completely located in the subcutaneous fat, with no involvement of the dermis.
  • [MeSH-major] Carcinoma, Merkel Cell / diagnosis. Neoplasms, Adipose Tissue / surgery. Skin Neoplasms / diagnosis

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  • (PMID = 15996429.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Colas S, Germain E, Arab K, Maheo K, Goupille C, Bougnoux P: Alpha-tocopherol suppresses mammary tumor sensitivity to anthracyclines in fish oil-fed rats. Nutr Cancer; 2005;51(2):178-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alpha-tocopherol suppresses mammary tumor sensitivity to anthracyclines in fish oil-fed rats.
  • Polyunsaturated fatty acids (PUFAs) have been reported to enhance the efficacy of chemotherapeutic agents that produce reactive oxygen species such as anthracyclines.
  • To determine the relevance of this observation in vivo, we examined the effect of the oxidative status of the diet on the activity of epirubicin against N-methylnitrosourea-induced mammary tumors in Sprague-Dawley rats.
  • When the first mammary tumor reached 1 cm2, epirubicin was administrated weekly for 3 wk, and subsequent change in tumor size was documented over time.
  • Two weeks after the end of epirubicin injections, tumor size was increased by 34% in the control group.
  • In the pro-oxidant group, tumor size was decreased by 50%.
  • In contrast, tumor size was increased by 188% in the antioxidant group.
  • Thus, addition of pro-oxidants in a fish oil-enriched diet increased the sensitization of mammary tumors to chemotherapy, whereas addition of alpha-tocopherol suppressed tumor response in vivo, indicating that interaction between components of the diet has to be carefully controlled during chemotherapy.
  • [MeSH-major] Anthracyclines / antagonists & inhibitors. Anthracyclines / pharmacology. Antioxidants / pharmacology. Diet / adverse effects. Drug Resistance, Neoplasm / drug effects. Fish Oils / administration & dosage. Mammary Neoplasms, Experimental / drug therapy. alpha-Tocopherol / pharmacology
  • [MeSH-minor] Adipose Tissue / drug effects. Adipose Tissue / metabolism. Animals. Antibiotics, Antineoplastic / antagonists & inhibitors. Antibiotics, Antineoplastic / pharmacology. Carcinogens. Disease Models, Animal. Drug Antagonism. Epirubicin / antagonists & inhibitors. Epirubicin / pharmacology. Fatty Acids, Unsaturated / pharmacology. Female. Malondialdehyde / metabolism. Methylnitrosourea. Oxidants / administration & dosage. Rats. Rats, Sprague-Dawley. Time Factors

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  • (PMID = 15860440.001).
  • [ISSN] 0163-5581
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthracyclines; 0 / Antibiotics, Antineoplastic; 0 / Antioxidants; 0 / Carcinogens; 0 / Fatty Acids, Unsaturated; 0 / Fish Oils; 0 / Oxidants; 3Z8479ZZ5X / Epirubicin; 4Y8F71G49Q / Malondialdehyde; 684-93-5 / Methylnitrosourea; H4N855PNZ1 / alpha-Tocopherol
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76. Sadeghian H, Eslami B, Shirani S, Sadeghian A: Lipomatous tumor of the tricuspid valve: report of a rare case. J Heart Valve Dis; 2009 Nov;18(6):720-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous tumor of the tricuspid valve: report of a rare case.
  • The case is reported of a 19-year-old man with cardiac valve lipomatosis which was accidentally discovered during the work-up for an atypical chest pain.
  • Magnetic resonance imaging showed evidence of tricuspid valve lipomatosis, a rare cardiac valve tumor.
  • After five months, echocardiography showed that the mass had not grown.
  • To the best of the present authors' knowledge, very few reports exist of cardiac valve lipomatous tumors.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Lipoma / ultrasonography. Tricuspid Valve / ultrasonography

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  • (PMID = 20099724.001).
  • [ISSN] 0966-8519
  • [Journal-full-title] The Journal of heart valve disease
  • [ISO-abbreviation] J. Heart Valve Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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77. Yamaguchi T, Takimoto T, Yamashita T, Kitahara S, Omura M, Ueda Y: Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney. Urology; 2005 Jan;65(1):175
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney.
  • Fat-containing variant of a solitary fibrous tumor is a recently recognized benign soft-tissue tumor that usually affects the thigh and retroperitoneum.
  • We report a 51-year-old woman with a fat-containing variant of a solitary fibrous tumor that is the first reported case involving a visceral organ.
  • The tumor was well delineated and seemed to arise from the renal capsule, radiographically and macroscopically.
  • The tumor microscopically mimicked a solitary fibrous tumor but exhibited focal aggregates of fat cells.
  • A fat-containing variant of a solitary fibrous tumor involving the kidney should be distinguished from spindle cell carcinoma, angiomyolipoma, gastrointestinal stromal tumor, and cellular schwannoma.
  • [MeSH-major] Adipose Tissue / pathology. Hemangiopericytoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 15667897.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Nilsson M, Domanski H, Mertens F, Mandahl N: Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12. Oncol Rep; 2005 Apr;13(4):649-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.
  • Atypical lipomatous tumor (ALT), an intermediate malignant neoplasm of soft tissues, is characterized by the presence of supernumerary ring and giant marker chromosomes.
  • The complex rearrangement was not only the result of multiple breaks and reunions of these chromosomes, but was also associated with a gain of chromosome 12 sequences.
  • Whether ALTs with these types of aberrations have a lower risk of tumor progression than ALTs with the notoriously mitotically unstable ring and giant marker chromosomes remains to be investigated.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 8. Lipoma / genetics. Lipoma / pathology. Neoplasms, Adipose Tissue / genetics. Neoplasms, Adipose Tissue / pathology
  • [MeSH-minor] Biopsy. Chromosome Banding. Chromosomes / ultrastructure. Disease Progression. Female. Humans. In Situ Hybridization, Fluorescence. Interphase. Karyotyping. Middle Aged. Phenotype

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  • (PMID = 15756437.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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79. Jeon ES, Lee IH, Heo SC, Shin SH, Choi YJ, Park JH, Park DY, Kim JH: Mesenchymal stem cells stimulate angiogenesis in a murine xenograft model of A549 human adenocarcinoma through an LPA1 receptor-dependent mechanism. Biochim Biophys Acta; 2010 Nov;1801(11):1205-13
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  • Carcinoma-associated fibroblasts play a key role in tumorigenesis and metastasis by providing a tumor-supportive microenvironment.
  • In the present study, we demonstrate that conditioned medium from A549 human lung adenocarcinoma cells induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) to carcinoma-associated fibroblasts expressing α-smooth muscle actin, vascular endothelial growth factor, and stromal cell-derived factor-1.
  • A549 conditioned medium-induced differentiation of hASCs to carcinoma-associated fibroblasts was completely abrogated by treatment of hASCs with Ki16425, a lysophosphatidic acid receptor antagonist, or knockdown of lysophosphatidic acid receptor 1 (LPA(1)) expression in hASCs with small interfering RNA or lentiviral short hairpin RNA.
  • Using a murine xenograft transplantation model of A549 cells, we showed that co-transplantation of hASCs with A549 cells stimulated growth of A549 xenograft tumor, angiogenesis, and differentiation of hASCs to carcinoma-associated fibroblasts in vivo.
  • Knockdown of LPA(1) expression in hASCs abrogated hASCs-stimulated growth of A549 xenograft tumor, angiogenesis, and differentiation of hASCs to carcinoma-associated fibroblasts.
  • These results suggest that A549 cells induce in vivo differentiation of hASCs to carcinoma-associated fibroblasts, which play a key role in tumor angiogenesis within tumor microenvironment, through an LPA-LPA(1)-mediated paracrine mechanism.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20708100.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Receptors, Lysophosphatidic Acid
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80. Krishnan AV, Swami S, Feldman D: Vitamin D and breast cancer: inhibition of estrogen synthesis and signaling. J Steroid Biochem Mol Biol; 2010 Jul;121(1-2):343-8
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  • Calcitriol (1,25-dihydroxyvitamin D3), the hormonally active metabolite of vitamin D, inhibits the growth and induces the differentiation of many malignant cells including breast cancer (BCa) cells.
  • Calcitriol also inhibits invasion, metastasis and tumor angiogenesis in experimental models of BCa.
  • Calcitriol decreases the expression of aromatase, the enzyme that catalyzes estrogen synthesis selectively in BCa cells and the breast adipose tissue surrounding BCa, by a direct repression of aromatase transcription via promoter II as well as an indirect effect due to the reduction in the levels and biological activity of PGE2, which is a major stimulator of aromatase transcription through promoter II in BCa.

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20156557.001).
  • [ISSN] 1879-1220
  • [Journal-full-title] The Journal of steroid biochemistry and molecular biology
  • [ISO-abbreviation] J. Steroid Biochem. Mol. Biol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA130991; United States / NCI NIH HHS / CA / CA130991
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 0 / Estrogens; 1406-16-2 / Vitamin D; EC 1.1.1.- / Hydroxyprostaglandin Dehydrogenases; EC 1.1.1.141 / 15-hydroxyprostaglandin dehydrogenase; EC 1.14.99.1 / Cyclooxygenase 2; FXC9231JVH / Calcitriol
  • [Number-of-references] 76
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81. Avellini C, Baccarani U, Orsaria M, Adani GL, Bresadola V, Lorenzin D, Bresadola F, Beltrami CA: Evaluation of prostate cancer staging in organ donors: intraoperative histology on periglandular soft tissues-a proposal. Transplant Proc; 2009 May;41(4):1099-103
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  • [Title] Evaluation of prostate cancer staging in organ donors: intraoperative histology on periglandular soft tissues-a proposal.
  • However, multiple biopsies may fail to represent the whole neoplasia, and grading may be difficult particularly because there may not be information about capsular penetration.
  • Since October 2007, 20 prostate autopsy specimens were submitted to an histopathologic screening method of the entire prostate based on extemporary frozen section analysis (maximum 75 minutes) of shavings of samples of the lateral surfaces of the prostate gland: namely, approximately 5 samples or 7 in the case of a large gland.
  • There were 7 cases of undiagnosed prostate cancer, three of which were demonstrated on frozen sections with neoplastic foci of extraglandular infiltration within connective and adipose tissues outside the gland.
  • No neoplasia was present in the other 13 cases.
  • In all cases, the final diagnosis was confirmed by the extemporary analysis.
  • Our goal was to confirm the optimal number of samples that were representative of the whole prostatic contour, to define time to diagnosis and to evaluate reproducibility of frozen-section histopathologic screening compared with paraffin sections.
  • [MeSH-major] Prostate / pathology. Prostatic Neoplasms / pathology. Tissue Donors
  • [MeSH-minor] Adipose Tissue / pathology. Biopsy. Frozen Sections. Humans. Intraoperative Period. Male. Neoplasm Staging. Prostate-Specific Antigen. Reproducibility of Results

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  • (PMID = 19460491.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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82. Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS: Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest; 2008 Jul;118(7):2640-50
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  • [Title] Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.
  • Adipose tissue inflammation is a characteristic of obesity.
  • However, the mechanisms that regulate this inflammatory response and link adipose inflammation to systemic metabolic consequences are not fully understood.
  • In this study, we have taken advantage of the highly restricted coexpression of adipocyte/macrophage fatty acid-binding proteins (FABPs) aP2 (FABP4) and mal1 (FABP5) to examine the contribution of these lipid chaperones in macrophages and adipocytes to local and systemic inflammation and metabolic homeostasis in mice.
  • The results of these experiments indicated that neither macrophages nor adipocytes individually could account for the total impact of FABPs on systemic metabolism and suggest that interactions between these 2 cell types, particularly in adipose tissue, are critical for the inflammatory basis of metabolic deterioration.

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  • (PMID = 18551191.001).
  • [ISSN] 0021-9738
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK71507-04; United States / NIDDK NIH HHS / DK / P30 DK040561; United States / NIDDK NIH HHS / DK / R90 DK071507; United States / NIDDK NIH HHS / DK / DK52540; United States / NIDDK NIH HHS / DK / P30 DK040561-13; United States / NHLBI NIH HHS / HL / HL65405; United States / NHLBI NIH HHS / HL / R01 HL065405; United States / NIDDK NIH HHS / DK / DK040561-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Ccl2 protein, mouse; 0 / Chemokine CCL2; 0 / Fabp4 protein, mouse; 0 / Fabp5 protein, mouse; 0 / Fatty Acid-Binding Proteins; 0 / Insulin; 0 / Neoplasm Proteins; 0 / Tumor Necrosis Factor-alpha; EC 2.7.10.1 / Receptor, Insulin; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; IY9XDZ35W2 / Glucose
  • [Other-IDs] NLM/ PMC2423863
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83. Takeshita N, Noie T, Otsuka Y, Hoshino A, Nara S, Ito K, Harihara Y, Furushima K, Konishi T: Fat replacement of the distal pancreas in a case of advanced gastric cancer. Int Surg; 2010 Jul-Sep;95(3):261-4
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  • Histopathologic examination of the resected pancreas revealed the absence of lobules, acini, conduits, and pancreatic ducts, with only islets of Langerhans found scattered in the adipose tissue.
  • In patients with fat-replaced pancreas, preoperative evaluation of direct invasion of adjacent organs/tissues by gastric cancer is difficult.
  • [MeSH-major] Adipose Tissue / pathology. Pancreas / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Atrophy. Endoscopy, Gastrointestinal. Gastrectomy. Humans. Liver / pathology. Liver / radiography. Male. Neoplasm Invasiveness. Pancreatectomy. Splenectomy. Tomography, X-Ray Computed

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  • (PMID = 21067007.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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84. Pressman G, Verma N: Pericardial fat masquerading as tumor. Echocardiography; 2010 Feb;27(2):E18-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pericardial fat masquerading as tumor.
  • One year prior she had undergone subtotal gastrectomy and jejunostomy in treatment of a large gastrointestinal stromal tumor.
  • Two-dimensional echocardiography was performed, which showed a small circumferential pericardial effusion with a soft tissue echo density attached to the right atrial/right ventricular junction that extended over the right ventricle.
  • Because of concern about possible malignant disease, thoracoscopy and biopsy of the pericardial mass were recommended.
  • Normal fibro-adipose tissue was found with no evidence of neoplasm.
  • In this case, the concomitant presence of a small pericardial effusion and prominent fat pad at the right atrial/right ventricular junction gave the appearance of pericardial tumor.
  • [MeSH-major] Adipose Tissue / ultrasonography. Echocardiography / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. False Positive Reactions. Female. Heart Neoplasms / ultrasonography. Humans

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  • (PMID = 20380671.001).
  • [ISSN] 1540-8175
  • [Journal-full-title] Echocardiography (Mount Kisco, N.Y.)
  • [ISO-abbreviation] Echocardiography
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Kazakov DV, Hes O, Hora M, Sima R, Michal M: Primary intranodal cellular angiolipoma. Int J Surg Pathol; 2005 Jan;13(1):99-101

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Angiolipoma is a distinct, benign soft tissue tumor that most commonly occurs in young males as multiple small, subcutaneous, tender to painful nodules with predilection for the forearms.
  • Microscopically, the major portion of the lymph node was replaced by mature metaplastic adipose tissue.
  • Lymph nodes are known to be a rare primary site of various tumors usually occurring in other organs.
  • The knowledge of these tumors is important in order not to interpret them as metastatic lesions.
  • The most recognized examples are pigmented nevi, palisading myofibroblastoma, various benign epithelial inclusions, serous cystic tumors of borderline malignancy, and hyperplastic mesothelial inclusions.
  • As we present in this report, angiolipoma is another neoplasm whose primary occurrence in the lymph node should not be misinterpreted as a metastatic tumor or malignant vascular tumor.
  • [MeSH-major] Angiolipoma / pathology. Lymph Nodes / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Aged. Antigens, CD31 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Lymphatic Metastasis / diagnosis. Male. Metaplasia / pathology

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  • (PMID = 15735863.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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86. Aftab S, Casey A, Tirabosco R, Kabir SR, Saifuddin A: Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review. Skeletal Radiol; 2010 Oct;39(10):1039-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review.
  • Solitary fibrous tumour (SFT) is a rare soft tissue tumour of uncertain histogenesis and unpredictable biological behaviour, which was first described in the pleura and subsequently in many extra-pleural locations.
  • We present the clinical, radiological and histological features of a case of intraspinal fat-forming SFT, along with a literature review.
  • This is the first known report of a fat-forming SFT in the spine.
  • [MeSH-major] Solitary Fibrous Tumors / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hemangiopericytoma / diagnosis. Hemangiopericytoma / surgery. Humans. Lipoma / diagnosis. Lipoma / surgery. Magnetic Resonance Imaging / methods. Male. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20628877.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] Lipomatous hemangiopericytoma
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87. Mentzel T, Palmedo G, Kuhnen C: Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. Mod Pathol; 2010 May;23(5):729-36
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [Title] Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases.
  • Well-differentiated spindle cell liposarcoma represents a rare atypical/low-grade malignant lipogenic neoplasm that has been regarded as a variant of atypical lipomatous tumor.
  • However, well-differentiated spindle cell liposarcoma tends to occur in subcutaneous tissue of the extremities, the trunk, and the head and neck region, contains slightly atypical spindled tumor cells often staining positively for CD34, and lacks an amplification of MDM2 and/or CDK4 in most of the cases analyzed.
  • The neoplasms arose on the shoulder, the chest wall, the thigh, the lower leg, the back of the hand, and in paratesticular location.
  • The size of the neoplasms ranged from 1.5 to 10 cm (mean: 6.0 cm).
  • All neoplasms were completely excised.
  • The neoplasms were confined to the subcutis in three cases, and in three cases, an infiltration of skeletal muscle was seen.
  • Histologically, the variably cellular neoplasms were composed of atypical lipogenic cells showing variations in size and shape, and spindled tumor cells with slightly enlarged, often hyperchromatic nuclei.
  • Multivacuolated lipoblasts were present in three neoplasms.
  • Immunohistochemically, CD34 was at least focally positive in all cases, whereas scattered tumor cells only showed a nuclear expression of MDM2 in two neoplasms.
  • Although well-differentiated spindle cell liposarcoma and atypical lipomatous tumor behave clinically similar, it can be speculated on the basis of clinicopathologic and molecular findings that well-differentiated spindle cell liposarcoma may constitute an independent entity rather than a morphologic variant of atypical lipomatous tumor, and may represent the atypical/low-grade counterpart of spindle cell lipoma.
  • [MeSH-major] Hand / pathology. Leg / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20228779.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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88. Calvo FA, Aldaz A, Zufía L, de la Mata D, Serrano J, García R, Arranz JA, Alvarado A, Giráldez J: Tegafur and 5-fluorouracil pelvic tissue concentrations in rectal cancer patients receiving preoperative chemoradiation. Clin Transl Oncol; 2006 Jul;8(7):500-7
Hazardous Substances Data Bank. FLUOROURACIL .

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  • [Title] Tegafur and 5-fluorouracil pelvic tissue concentrations in rectal cancer patients receiving preoperative chemoradiation.
  • BACKGROUND AND PURPOSE: To investigate the presence of 5-Fluorouracil (5-FU) in pelvic tissue after oral administration of tegafur.
  • To measure tegafur and 5-FU concentrations in normal rectal mucosa, perirectal fat and residual tumor in rectal cancer patients receiving preoperative chemoradiation.
  • PATIENTS AND METHODS: Three tissue samples taken from 16 surgical specimens after recto-sigmoid resection were analyzed.
  • RESULTS: In 8 of the 9 patients who did not receive a precharge dose, detectable levels of tegafur were observed in fat tissue, normal mucosa and tumor, but detectable 5-FU levels were only observed in one patient.
  • Mean concentrations (ranges) for tegafur in fat, normal mucosa and tumor in patients without the precharge dose were 72.19 (12.1-205.6), 179.53 (11.30-727.7) and 252.35 (27.9-874.6) ng/g, respectively; mean concentrations for 5-FU in the same samples were 0.95, 1.92 and 2.68 ng/g (1 patient), respectively.
  • In patients receiving a tegafur precharge, both tegafur and 5-FU were present in all tissue samples with the exception of 2 fat samples, in which drug concentrations were undetectable.
  • 5-FU levels were higher in tumor than other sites, with a median value of 68.24 ng/g (range 3.8-283.05 ng/g).
  • Tegafur levels were also higher in tumor samples than other sites (mean 3446.53 ng/g, range 1044.5-7847.0 ng/g), except in 2 patients who had higher levels of tegafur in normal mucosa.
  • CONCLUSIONS: Tegafur and 5-FU are not always present in pelvic tissues 5 to 6 weeks after oral administration of tegafur.
  • Both drugs were present in the tissues analyzed, in relevant concentrations, 24 hours after oral administration of tegafur.
  • The data obtained suggest a tendency (not significant) toward a correlation between levels of 5-FU present in the residual tumor and cancer downstaging.
  • [MeSH-major] Antimetabolites, Antineoplastic / metabolism. Fluorouracil / metabolism. Rectal Neoplasms / drug therapy. Rectal Neoplasms / radiotherapy. Tegafur / metabolism
  • [MeSH-minor] Adipose Tissue / metabolism. Adult. Aged. Female. Humans. Intestinal Mucosa / metabolism. Male. Middle Aged. Neoplasm, Residual / metabolism. Pelvis. Rectum / metabolism. Treatment Outcome

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  • (PMID = 16870540.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 1548R74NSZ / Tegafur; U3P01618RT / Fluorouracil
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89. Saldanha-Araujo F, Haddad R, Zanette DL, De Araujo AG, Orellana MD, Covas DT, Zago MA, Panepucci RA: Cancer/Testis antigen expression on mesenchymal stem cells isolated from different tissues. Anticancer Res; 2010 Dec;30(12):5023-7
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  • [Title] Cancer/Testis antigen expression on mesenchymal stem cells isolated from different tissues.
  • BACKGROUND/AIMS: The expression of cancer/testis antigens (CTAs) on additional normal tissues or stem cells may restrict their use as cancer targets.
  • The objective of the present study was to evaluate the mRNA levels of some CTAs in a variety of tissues.
  • MATERIALS AND METHODS: mRNA of pericytes, fibroblasts and mesenchymal stem cells (MSCs) derived from adult and fetal tissues, human umbilical vein endothelial cells, MSC-derived adipocytes, selected normal tissues and control cancer cell lines (CLs) were extracted and quantitative polymerase chain reaction was performed for MAGED1, PRAME, CTAG1B, MAGEA3 and MAGEA4.
  • RESULTS: MAGED1 was expressed in all normal tissues and cells evaluated.
  • CTAG1B was expressed at levels comparable to control CLs on MSCs derived from arterial, fetal skin, adipose tissue and saphenous vein, heart, brain and skin tissues.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Mesenchymal Stromal Cells / immunology
  • [MeSH-minor] Fibroblasts / immunology. Humans. Immunophenotyping. Melanoma-Specific Antigens. Membrane Proteins / biosynthesis. Neoplasm Proteins / biosynthesis. Pericytes / immunology

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  • (PMID = 21187485.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / MAGEA1 protein, human; 0 / MAGEA3 protein, human; 0 / MAGEA4 protein, human; 0 / MAGED1 protein, human; 0 / Melanoma-Specific Antigens; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / PRAME protein, human
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90. Campa D, Hüsing A, McKay JD, Sinilnikova O, Vogel U, Tjønneland A, Overvad K, Stegger J, Clavel-Chapelon F, Chabbert-Buffet N, Fagherazzi G, Trichopoulou A, Zylis D, Oustoglou E, Rohrmann S, Teucher B, Fisher E, Boeing H, Masala G, Krogh V, Sacerdote C, Panico S, Tumino R, Onland-Moret NC, van Gils CH, Bueno-de-Mesquita HB, Lund E, Chirlaque MD, Sala N, Quirós JR, Ardanaz E, Amiano P, Molina-Montes E, Hallmans G, Lenner P, Travis RC, Key TJ, Wareham N, Khaw KT, Rinaldi S, Slimani N, Chajes V, Siddiq A, Riboli E, Kaaks R, Canzian F: The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer; 2010 Oct 18;10:563
Repositorio Institucional de Salud de Andalucia. Full Text from .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.
  • BACKGROUND: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI).
  • RESULTS AND CONCLUSIONS: In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.
  • [MeSH-major] Breast Neoplasms / genetics. Intracellular Signaling Peptides and Proteins / genetics. Membrane Proteins / genetics. Polymorphism, Genetic
  • [MeSH-minor] Adipose Tissue. Adult. Aged. Body Mass Index. Case-Control Studies. Cohort Studies. Female. Genome-Wide Association Study. Genotype. Humans. Middle Aged. Models, Genetic. Neoplasm Invasiveness. Risk

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  • (PMID = 20955599.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Grant] United Kingdom / British Heart Foundation / / ; United Kingdom / Medical Research Council / / ; United Kingdom / Department of Health / / ; United Kingdom / Cancer Research UK / / ; United Kingdom / Medical Research Council / / MRC/ MC/ U106179471; United Kingdom / Wellcome Trust / / ; United Kingdom / Medical Research Council / / MRC/ G0401527
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / INSIG2 protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2965729
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91. Jara-Lazaro AR, Akhilesh M, Thike AA, Lui PC, Tse GM, Tan PH: Predictors of phyllodes tumours on core biopsy specimens of fibroepithelial neoplasms. Histopathology; 2010 Aug;57(2):220-32
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictors of phyllodes tumours on core biopsy specimens of fibroepithelial neoplasms.
  • AIMS: To establish histological and biological parameters that can predict phyllodes tumours on core biopsy specimens of indeterminate fibroepithelial neoplasms.
  • Cases in which phyllodes tumour was favoured, or could not be ruled out, were evaluated for stromal cellularity/distribution, nuclear atypia and mitoses, stromal overgrowth, epithelial fronding, epithelial hyperplasia, configuration of lesional edge, presence of pseudoangiomatous stromal hyperplasia and of adipose tissue.
  • Of 261 core biopsy specimens of fibroepithelial lesions, 98 (37%) comprised cases in which phyllodes tumour could not be excluded and 57 (58%) had subsequent open surgical excisions.
  • Marked stromal hypercellularity (5/5; 100%) and nuclear atypia (1/1; 100%), stromal overgrowth (17/17; 100%), mitoses > or =2/10 high-power fields (18/18; 100%) and ill-defined lesional borders (16/16 phyllodes tumours; 100%) were features in core biopsy specimens that exclusively predicted phyllodes tumour on excision.
  • Immunohistochemical markers Ki67 > or =5% and topoisomerase IIalpha> or =5%, and reduced or patchy CD34 on core biopsy specimens correlated significantly with a diagnosis of phyllodes.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Fibroadenoma / diagnosis. Fibroadenoma / pathology. Phyllodes Tumor / diagnosis. Phyllodes Tumor / pathology
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / metabolism. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Biopsy, Needle. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Middle Aged. Predictive Value of Tests. Young Adult

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  • (PMID = 20716164.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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92. LaPensee EW, Ben-Jonathan N: Novel roles of prolactin and estrogens in breast cancer: resistance to chemotherapy. Endocr Relat Cancer; 2010 Jun;17(2):R91-107
Hazardous Substances Data Bank. BISPHENOL A .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The PRL receptor is activated by lactogens (PRL, GH, or placental lactogen) originating from the pituitary, breast, adipose tissue, or the placenta.
  • Focusing on cisplatin, a DNA-damaging drug which is effective in the treatment of many cancer types but not breast cancer, we compare the abilities of PRL, E(2), and BPA to antagonize its cytotoxicity.
  • [MeSH-major] Breast Neoplasms / drug therapy. Drug Resistance, Neoplasm. Estradiol / metabolism. Prolactin / metabolism

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  • (PMID = 20071456.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / 5T32ES007250; United States / NCI NIH HHS / CA / CA096613; United States / NIEHS NIH HHS / ES / ES012212; United States / NIEHS NIH HHS / ES / P30 ES06096
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzhydryl Compounds; 0 / Phenols; 0 / Receptors, Estrogen; 0 / Receptors, Prolactin; 4TI98Z838E / Estradiol; 9002-62-4 / Prolactin; EC 2.5.1.18 / Glutathione Transferase; MLT3645I99 / bisphenol A; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 145
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93. Puppa G, Maisonneuve P, Sonzogni A, Masullo M, Capelli P, Chilosi M, Menestrina F, Viale G, Pelosi G: Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging. Mod Pathol; 2007 Aug;20(8):843-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging.
  • The current TNM classification considers a tumor nodule in the pericolic/perirectal adipose tissue as venous invasion if the nodule has an irregular contour and as regional lymph node metastasis if the nodule has the form and smooth contour of a lymph node.
  • However, detailed studies on the clinico-pathological implications of pericolonic tumor deposits and of extranodal extension are still lacking.
  • The pericolonic tumor deposits were characterized by their appearance, size, distance from the primary tumor and by their relation with the lymphatic tissue not organized in lymph nodes.
  • These features were then compared with the clinico-pathological characteristics of the tumors and with the patients' survival.
  • All these lesions were associated with reduced disease-free and overall survivals in a univariate analysis, but only pericolonic tumor deposits retained an independent prognostic role in the multivariate analysis.
  • Our findings suggest that pericolonic tumor deposits are a destructive type of venous invasion different from other types of vessel involvement, and that these lesions may rather be included in the M category for staging purposes.
  • [MeSH-major] Adenocarcinoma / pathology. Colon / pathology. Colonic Neoplasms / pathology
  • [MeSH-minor] Disease-Free Survival. Humans. Intra-Abdominal Fat / pathology. Kaplan-Meier Estimate. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Time Factors. Veins / pathology

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  • (PMID = 17491597.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Benzoni E, Intersimone D, Terrosu G, Bresadola V, Cojutti A, Cerato F, Avellini C: Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer. J Clin Pathol; 2006 May;59(5):505-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer.
  • METHODS: From 1994 to 2003, 58 patients with rectal cancer were enrolled in a non-randomised study based on standardised treatment with radiotherapy, 5-fluorouracil, and surgical resection, followed by histological examination, including tumour regression grading and depth of neoplastic infiltration within the perirectal fat.
  • Tumour regression was defined as grade 1 in 24.5% of cases, grade 2 in 58.5%, grade 3 in 7.5%, and grade 4 (complete regression) in 9.5%.
  • Tumour regression grading was an independent variable for pT (p = 0.0002), pN status (p = 0.00004), pathological staging (p = 0.000001), and local recurrence (p = 0.003).
  • Tumour regression grading and the depth of neoplastic infiltration within the perirectal fat are important prognostic factors that need to be evaluated routinely.
  • [MeSH-major] Adenocarcinoma / pathology. Adipose Tissue / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Prognosis. Radiotherapy, Adjuvant. Survival Rate

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  • (PMID = 16522747.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1860296
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95. Hong SM, Kim MJ, Pi DY, Jo D, Cho HJ, Yu E, Ro JY: Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients. Cancer; 2005 Aug 15;104(4):802-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients.
  • BACKGROUND: Although the sixth edition of the American Joint Committee on Cancer (AJCC) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on T classification due to its ambiguous definition of T1 as "tumor confined to bile duct histologically" and T2 as "tumor invading beyond the bile duct."
  • METHODS: The authors considered the outermost part of the muscle layer or fibrous tissue as within the extrahepatic bile duct and considered the area starting from large clusters of adipose tissue as beyond the extrahepatic bile duct.
  • RESULTS: The 5-year survival rates for patients with tumors that were classified as T1, T2, T3, and T4 were 53.1%, 29.7%, 24.9%, and 0%, respectively.
  • There was a significant difference in survival between patients with T1 tumors and T2 tumors (P < 0.05), but not between patients with T2 tumors and T3 tumors.
  • [MeSH-major] Bile Duct Neoplasms / classification. Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods. Prognosis. Survival Analysis

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  • (PMID = 15959914.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Crombez KR, Vanoirbeek EM, Van de Ven WJ, Petit MM: Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. Mol Cancer Res; 2005 Feb;3(2):63-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2.
  • The gene encoding the architectural transcription factor HMGA2 is frequently rearranged in several benign tumors of mesenchymal origin.
  • The lipoma preferred partner (LPP) gene is the most frequent translocation partner of HMGA2 in a subgroup of lipomas, which are benign tumors of adipose tissue.
  • Identical fusion transcripts are also expressed in other benign mesenchymal tumors.
  • [MeSH-minor] Amino Acid Motifs. Cells, Cultured. Cytoskeletal Proteins / genetics. Cytoskeletal Proteins / physiology. Gene Expression Regulation, Neoplastic. Humans. LIM Domain Proteins. Neoplasm Proteins / genetics. Neoplasm Proteins / physiology. Promoter Regions, Genetic / genetics. Protein Structure, Tertiary. Rhodopsin / genetics. Transcription, Genetic

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  • (PMID = 15755872.001).
  • [ISSN] 1541-7786
  • [Journal-full-title] Molecular cancer research : MCR
  • [ISO-abbreviation] Mol. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / HMGA Proteins; 0 / HMGA2 Protein; 0 / HMGA2-LPP fusion protein, human; 0 / LIM Domain Proteins; 0 / LPP protein, human; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 9009-81-8 / Rhodopsin
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97. Brandal P, Bjerkehagen B, Heim S: Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol; 2006 Feb;208(3):388-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology.
  • Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have different more or less specific chromosomal abnormalities.
  • One such entity is lipoblastoma, which is a benign lipomatous tumour that often exhibits rearrangements of chromosome bands 8q11-13, and the gene PLAG1 has been implicated as the target of these chromosomal changes.
  • All lipomatous tumours karyotyped at the Norwegian Radium Hospital were reviewed, looking for rearrangements of 8q11-13.
  • The findings raise the question as to what extent the diagnosis lipoblastoma should be based on histopathological or cytogenetic/molecular data or a combination thereof.
  • When karyotypic information from this series was combined with available literature data, it was found that the sensitivity of 8q11-13 rearrangements for diagnosing lipoblastomas when found in a lipomatous tumour was 77% and that the corresponding specificity was 98%.
  • The validity of these calculations of the diagnostic information provided by the cytogenetic findings is, of course, totally dependent on the morphological diagnosis made in each case.
  • Regardless of what the precise phenotypic diagnosis was, it is suggested that lipomatous tumours with 8q11-13 rearrangement constitute a distinct pathogenetic entity.
  • When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8. Gene Rearrangement. Lipoma / genetics. Neoplasms, Adipose Tissue / genetics

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  • (PMID = 16308870.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / PLAG1 protein, human
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98. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • Multinucleated floret cells present in prolapsed orbital fat likely represent a reactive phenomenon, as they are not present in normal orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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99. Pakos EE, Gogou PV, Apostolikas N, Batistatou A, Tsekeris PG: Factors associated with outcome in liposarcomas of the extremities and trunk. J BUON; 2010 Jul-Sep;15(3):518-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Liposarcomas are malignant tumors that arise from primitive mesenchymal cells rather than mature adipose tissue.
  • In univariate analysis factors that were significantly associated with outcomes were grade III tumors, amputation procedures, use of chemotherapy and development of local recurrences.
  • The development of metastases is observed within the first 5-years from diagnosis.
  • Metastatic disease after that period is rare.
  • The possibility of local recurrence is not negligible after the 5th year of follow up.
  • [MeSH-major] Liposarcoma / mortality. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Extremities. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Proportional Hazards Models. Retrospective Studies. Risk Factors. Survival Rate

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  • (PMID = 20941821.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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100. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • [Title] Radiological localizing techniques in adrenal tumors.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Incidental Findings. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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