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6. Karapanagiotou EM, Tsochatzis EA, Dilana KD, Tourkantonis I, Gratsias I, Syrigos KN: The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer (NSCLC). Lung Cancer; 2008 Sep;61(3):391-7
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  • SUMMARY: Adipose tissue secretes adipokines with proinflammatory and anti-inflammatory properties.
  • Our aim was to assess the role of adipose tissue in generalized inflammatory state of advanced NSCLC patients and the possible use of leptin, adiponectin and resistin as diagnostic and prognostic markers.
  • Correlation of adipose tissue with weight loss in advanced NSCLC patients was also studied.
  • Adipokine serum levels were determined at diagnosis, at the end of first-line chemotherapy and at the time of disease progression for those who responded to treatment.
  • Multivariate analysis showed that these adipokines at diagnosis could not be used as predictive factors for overall survival or time to progression.
  • [MeSH-major] Adiponectin / blood. Carcinoma, Non-Small-Cell Lung / blood. Leptin / blood. Lung Neoplasms / blood. Resistin / blood
  • [MeSH-minor] Analysis of Variance. Biomarkers, Tumor / blood. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male. Middle Aged. Neoplasm Staging. Proportional Hazards Models. Prospective Studies. Statistics, Nonparametric


7. Novikov VV, Novikov GV, Fesenko EE: Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics; 2009 Jul;30(5):343-51
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  • [Title] Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma.
  • It was shown that the exposure of mice with EAC to combined MFs causes structural changes in some organs (liver, adrenal glands), which are probably due to the total degradation of the tumor tissue.
  • In mice with transplanted EAC, the tumor tissue after exposure to weak MFs was practically absent, as distinct from control animals in which the invasion of the tumor into the adipose tissue surrounding the kidneys, mesenteric lymph nodes, and spermatic appendages was observed.
  • In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism.
  • [MeSH-major] Carcinoma, Ehrlich Tumor / pathology. Carcinoma, Ehrlich Tumor / therapy. Magnetic Field Therapy / methods. Magnetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19267367.001).
  • [ISSN] 1521-186X
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Pons Y, Ukkola-Pons E, Clément P, Gauthier J, Conessa C: Relevance of 5 different imaging signs in the evaluation of carotid artery invasion by cervical lymphadenopathy in head and neck squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 May;109(5):775-8
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  • SUBJECTS AND METHODS: Between September 2001 and September 2008, 22 patients (20 men and 2 women) presented with lymph node metastasis of a head and neck squamous cell carcinoma that invaded the carotid artery.
  • In comparison, the isolated existence of encasement of more than 180 degrees or segmental obliteration of fat could not strictly indicate massive invasion of the carotid artery; thus, CAD could be planned.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Carotid Arteries / pathology. Carotid Artery Diseases / diagnosis. Head and Neck Neoplasms / pathology. Lymphatic Metastasis / diagnosis
  • [MeSH-minor] Adipose Tissue / pathology. Adipose Tissue / radiography. Contrast Media. Dissection / methods. Elastic Tissue / pathology. Elastic Tissue / radiography. Female. Humans. Lymph Nodes / pathology. Lymph Nodes / radiography. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Tomography, X-Ray Computed


9. Petrolla AA, Xin W: Hepatic angiomyolipoma. Arch Pathol Lab Med; 2008 Oct;132(10):1679-82
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  • Hepatic angiomyolipoma is a rare, benign, hepatic mesenchymal neoplasm found in both males and females, and most commonly in adult females.
  • Hepatic angiomyolipomas are composed of varying amounts of smooth muscle cells, adipose tissue, and vessels.
  • The smooth muscle cell component is the most specific to the diagnosis.
  • The differential diagnosis includes hepatocellular carcinoma, hepatic adenoma, leiomyoma, hepatoblastoma, melanoma, and gastrointestinal stromal tumor.
  • If the diagnosis of hepatic angiomyolipoma has been made, it can be followed conservatively or surgically resected.
  • [MeSH-major] Angiomyolipoma / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm / metabolism. Female. Humans. MART-1 Antigen. Male. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. S100 Proteins / metabolism

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  • (PMID = 18834230.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
  • [Number-of-references] 17
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10. Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA: Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am J Physiol Endocrinol Metab; 2006 May;290(5):E814-23
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  • [Title] Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice.
  • Fatty acid-binding proteins (FABPs) facilitate the diffusion of fatty acids within cellular cytoplasm.
  • Compared with C57Bl/6J mice maintained on a high-fat diet, adipose-FABP (A-FABP) null mice exhibit increased fat mass, decreased lipolysis, increased muscle glucose oxidation, and attenuated insulin resistance, whereas overexpression of epithelial-FABP (E-FABP) in adipose tissue results in decreased fat mass, increased lipolysis, and potentiated insulin resistance.
  • In contrast, de novo lipogenesis and expression of genes encoding lipoprotein lipase, CD36, long-chain acyl-CoA synthetase 5, and diacylglycerol acyltransferase are increased in A-FABP/aP2 null mice relative to E-FABP transgenic animals.
  • Consistent with an increase in de novo lipogenesis, there was an increase in adipose C16:0 and C16:1 acyl-CoA pools.
  • There were no changes in serum free fatty acids between genotypes.
  • Serum levels of resistin were decreased in the E-FABP transgenic mice, whereas serum and tissue adiponectin were increased in A-FABP/aP2 null mice and decreased in E-FABP transgenic animals; leptin expression was unaffected.

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  • (PMID = 16303844.001).
  • [ISSN] 0193-1849
  • [Journal-full-title] American journal of physiology. Endocrinology and metabolism
  • [ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK040936; United States / NIDDK NIH HHS / DK / DK-053189; United States / NIDDK NIH HHS / DK / DK-40936; United States / NIDDK NIH HHS / DK / DK-59635
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Carrier Proteins; 0 / Fabp4 protein, mouse; 0 / Fabp5 protein, mouse; 0 / Fatty Acid-Binding Proteins; 0 / Fatty Acids; 0 / Fatty Acids, Nonesterified; 0 / Fatty Acids, Unsaturated; 0 / Leptin; 0 / Neoplasm Proteins; 0 / Peptide Hormones; 0 / Phosphoproteins; 0 / Resistin; 0 / perilipin 1
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11. Dietrich D, Schuster M, Lesche R, Haedicke W, Kristiansen G: [Multiplexed methylation analysis--a new technology to analyse the methylation pattern of laser microdissected cells of normal breast tissue, DCIS and invasive ductal carcinoma of the breast]. Verh Dtsch Ges Pathol; 2007;91:197-207
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  • [Title] [Multiplexed methylation analysis--a new technology to analyse the methylation pattern of laser microdissected cells of normal breast tissue, DCIS and invasive ductal carcinoma of the breast].
  • AIMS: DNA methylation has been shown to play an important role in breast cancer pathogenesis, but up until now it is not clear how the tissue components contribute to the overall methylation of the sample, because microdissection does not provide sufficient material for most standard methylation assays.
  • METHODS: We developed a technology to analyse several methylation markers in a limited number of cells dissected from tissue sections.
  • The microdissected samples were from the invasive part, the intraductal part, the stroma, tumor infiltrating lymphocytes, chest wall muscle, adipose tissue and healthy ducts.
  • In all analysed patients PITX2 and RASSF1A were highly methylated in invasive and intraductal carcinoma cells compared to other tissue components.
  • PITX2 showed some methylation in normal adjacent breast tissue.
  • The methylation of the individual markers varied little within one tissue type and between blocks.
  • CONCLUSIONS: This technology is a powerful tool to analyse the methylation of multiple markers in different microdissected tissue components.
  • Methylation patterns may differ significantly between different markers and tissue components.
  • [MeSH-major] Breast / cytology. Breast Neoplasms / genetics. Breast Neoplasms / pathology. DNA Methylation. DNA, Neoplasm / genetics

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  • (PMID = 18314615.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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12. Naya Y, Zenbutsu S, Araki K, Nakamura K, Kobayashi M, Kamijima S, Imamoto T, Nihei N, Suzuki H, Ichikawa T, Igarashi T: Influence of visceral obesity on oncologic outcome in patients with renal cell carcinoma. Urol Int; 2010;85(1):30-6
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  • OBJECTIVE: At present, computed tomography (CT) is used in almost all patients with renal tumors.
  • We aimed to investigate the relationship between visceral adipose tissue (VAT), as assessed by CT, and various other factors in patients with renal cell carcinoma (RCC).
  • Pathological stage, microvascular invasion, tumor grade, performance status, C-reactive protein, BMI, hypertension, hyperlipemia, hyperglycemia, history of smoking and cause-specific survival rate were examined in relation to VAT, and multivariate Cox regression analysis was used to determine significant predictors of cause-specific survival.
  • RESULTS: VAT in patients with stage I disease was significantly greater than that in patients with more advanced disease (p = 0.0219).
  • [MeSH-major] Adiposity. Carcinoma, Renal Cell / surgery. Intra-Abdominal Fat / physiopathology. Kidney Neoplasms / surgery. Nephrectomy. Obesity / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Japan. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Risk Factors. Survival Rate. Time Factors. Tomography, X-Ray Computed. Treatment Outcome


13. Abe H, Schmidt RA, Kulkarni K, Sennett CA, Mueller JS, Newstead GM: Axillary lymph nodes suspicious for breast cancer metastasis: sampling with US-guided 14-gauge core-needle biopsy--clinical experience in 100 patients. Radiology; 2009 Jan;250(1):41-9
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  • The absence of any discernible fatty hilum was also noted.
  • All 44 patients who did not undergo CNB because of negative US results subsequently underwent SLNB, which revealed lymph node metastasis in 12 (27%) patients.
  • Cortical thickening was found in 63 (79%) of the total of 80 metastatic nodes, but only a minority (n = 26 [32%]) of the nodes had an absent fatty hilum.
  • Both absence of a fatty hilum (metastasis detected in 26 [93%] of 28 nodes) and cortical thickening combined with NHBF (metastasis detected in 52 [81%] of 64 nodes) had a high positive predictive value.
  • [MeSH-major] Biopsy, Needle. Breast Neoplasms / ultrasonography. Lymph Nodes / ultrasonography. Lymphatic Metastasis / ultrasonography. Ultrasonography, Interventional. Ultrasonography, Mammary
  • [MeSH-minor] Adipose Tissue / pathology. Adipose Tissue / ultrasonography. Adult. Aged. Aged, 80 and over. Axilla. Carcinoma, Ductal / pathology. Carcinoma, Ductal / ultrasonography. Carcinoma, Intraductal, Noninfiltrating / pathology. Carcinoma, Intraductal, Noninfiltrating / ultrasonography. Carcinoma, Lobular / pathology. Carcinoma, Lobular / ultrasonography. Female. Humans. Lymph Node Excision. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / ultrasonography. Neoplasm Staging. Prognosis. Retrospective Studies. Sensitivity and Specificity. Sentinel Lymph Node Biopsy. Ultrasonography, Doppler, Color

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  • [Copyright] (c) RSNA, 2008.
  • (PMID = 18955508.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Mete O, Rotstein L, Asa SL: Controversies in thyroid pathology: thyroid capsule invasion and extrathyroidal extension. Ann Surg Oncol; 2010 Feb;17(2):386-91
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  • In this article, we confront another controversy, the definition of a thyroid "capsule" to clarify what constitutes extrathyroidal extension (ETE) and its clinical significance in the management of patients with differentiated thyroid carcinomas.
  • Moreover, the presence of adipose tissue within the thyroid gland and its pseudocapsule implies that thyroid tumor within fat tissue cannot be accepted as a criterion of ETE by that thyroid carcinoma.
  • While invasion of skeletal muscle is a more reliable feature of ETE, at the isthmus, these fibers can be normally present within the gland, and this criterion does not have value.
  • [MeSH-major] Connective Tissue / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Humans. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Thyroid Gland / anatomy & histology

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  • (PMID = 19949881.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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16. Abdulkader M, Abercrombie J, McCulloch TA, Kaye PV: Colonic angiomyolipoma with a monotypic expression and a predominant epithelioid component. J Clin Pathol; 2005 Oct;58(10):1107-9
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  • Angiomyolipomas are rare lesions, often arising in the kidney, and are part of a group of tumours with a diverse appearance and evidence of dual melanocytic and smooth muscle differentiation known as PEComas (tumours of perivascular epithelioid cell origin).
  • This report describes an unusual case of a colonic PEComa in a 40 year old woman.
  • Unlike most of the previous colonic angiomyolipomas/PEComas reported in the literature, this case formed a large, mainly extrinsic mass and was monotypic, and composed entirely of the myomatous component with no adipose tissue or typical vasculature.
  • [MeSH-major] Angiomyolipoma / ultrastructure. Cecal Neoplasms / ultrastructure
  • [MeSH-minor] Adult. Female. Humans. Neoplasm Invasiveness

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  • (PMID = 16189161.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
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17. Ozbudak IH, Dertsiz L, Bassorgun CI, Ozbilim G: Giant cystic chondroid hamartoma of the lung. J Pediatr Surg; 2008 Oct;43(10):1909-11
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  • Pulmonary hamartoma composed of an abnormal mixture of mesenchymal elements is the most common benign neoplasm in the lung.
  • Multilocular cystic spaces with intervening lobulated fragments of cartilaginous tissue and adipose tissue were seen.
  • Microscopically, the solid component was composed of cartilage and adipose tissue.
  • We suggest that giant cystic pulmonary hamartoma should be included in the differential diagnosis of large intrathoracic masses in children.
  • [MeSH-minor] Adipose Tissue / pathology. Calcinosis / pathology. Calcinosis / radiography. Calcinosis / surgery. Cartilage / pathology. Child. Diagnosis, Differential. Epithelium / pathology. Humans. Incidental Findings. Lung Neoplasms / diagnosis. Male. Thoracotomy. Tomography, X-Ray Computed

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  • (PMID = 18926231.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • We present a rare atypical lipomatous tumour with spindle cell features (synonym: well-differentiated spindle cell liposarcoma) arising on the left palm of a 54-year-old male patient.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • However, focally, atypia of adipocytic and stromal cells as well as scattered lipoblasts were noted, and immunohistochemical stainings showed focal overexpression of MDM 2 and CDK4.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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19. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • Multinucleated floret cells present in prolapsed orbital fat likely represent a reactive phenomenon, as they are not present in normal orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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20. Pressman G, Verma N: Pericardial fat masquerading as tumor. Echocardiography; 2010 Feb;27(2):E18-20
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  • [Title] Pericardial fat masquerading as tumor.
  • One year prior she had undergone subtotal gastrectomy and jejunostomy in treatment of a large gastrointestinal stromal tumor.
  • Two-dimensional echocardiography was performed, which showed a small circumferential pericardial effusion with a soft tissue echo density attached to the right atrial/right ventricular junction that extended over the right ventricle.
  • Because of concern about possible malignant disease, thoracoscopy and biopsy of the pericardial mass were recommended.
  • Normal fibro-adipose tissue was found with no evidence of neoplasm.
  • In this case, the concomitant presence of a small pericardial effusion and prominent fat pad at the right atrial/right ventricular junction gave the appearance of pericardial tumor.
  • [MeSH-major] Adipose Tissue / ultrasonography. Echocardiography / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. False Positive Reactions. Female. Heart Neoplasms / ultrasonography. Humans

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  • (PMID = 20380671.001).
  • [ISSN] 1540-8175
  • [Journal-full-title] Echocardiography (Mount Kisco, N.Y.)
  • [ISO-abbreviation] Echocardiography
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Cao DX, Wu GH, Yang ZA, Zhang B, Jiang Y, Han YS, He GD, Zhuang QL, Wang YF, Huang ZL, Xi QL: Role of beta1-adrenoceptor in increased lipolysis in cancer cachexia. Cancer Sci; 2010 Jul;101(7):1639-45
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  • Gene expressions of beta1-adrenoceptor (ADRB1), beta2-adrenoceptor (ADRB2), beta3-adrenoceptor (ADRB3), alpha2C-adrenoceptor (ADRA2C), natriuretic peptide receptor A (NPRA), insulin receptor (INSR), and HSL were determined in adipose tissues of 34 patients by real-time PCR.
  • [MeSH-major] Cachexia / physiopathology. Lipolysis / genetics. Neoplasms / genetics. Receptors, Adrenergic, beta-1 / physiology
  • [MeSH-minor] Adipose Tissue / anatomy & histology. Adipose Tissue / metabolism. Adipose Tissue / pathology. Adult. Aged. Fatty Acids, Nonesterified / metabolism. Female. G-Protein-Coupled Receptor Kinase 3 / genetics. Gastrointestinal Neoplasms / genetics. Gastrointestinal Neoplasms / surgery. Humans. Male. Middle Aged. Patient Selection. Polymerase Chain Reaction. RNA, Neoplasm / genetics. RNA, Neoplasm / isolation & purification. Receptor, Insulin / genetics. Receptors, Atrial Natriuretic Factor / genetics

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  • (PMID = 20426789.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ADRB1 protein, human; 0 / Fatty Acids, Nonesterified; 0 / RNA, Neoplasm; 0 / Receptors, Adrenergic, beta-1; EC 2.7.10.1 / Receptor, Insulin; EC 2.7.11.15 / ADRBK2 protein, human; EC 2.7.11.15 / G-Protein-Coupled Receptor Kinase 3; EC 4.6.1.2 / Receptors, Atrial Natriuretic Factor; EC 4.6.1.2 / atrial natriuretic factor receptor A
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22. Truong MT, Erasmus JJ, Macapinlac HA, Marom EM, Mawlawi O, Gladish GW, Sabloff BS, Bruzzi JF, Munden RF: Integrated positron emission tomography/computed tomography in patients with non-small cell lung cancer: normal variants and pitfalls. J Comput Assist Tomogr; 2005 Mar-Apr;29(2):205-9
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  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Image Processing, Computer-Assisted / instrumentation. Lung Neoplasms / diagnosis. Positron-Emission Tomography / instrumentation. Tomography, Spiral Computed / instrumentation
  • [MeSH-minor] Adipose Tissue, Brown / pathology. Aged. Arteriosclerosis / diagnosis. Arteriosclerosis / pathology. Artifacts. Blood Glucose / metabolism. Contrast Media / administration & dosage. Contrast Media / pharmacokinetics. Diagnosis, Differential. Diagnostic Errors. Female. Fluorodeoxyglucose F18 / pharmacokinetics. Humans. Iatrogenic Disease. Lung / pathology. Male. Middle Aged. Muscle, Skeletal / pathology. Neoplasm Staging. Reference Values. Sensitivity and Specificity

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  • (PMID = 15772538.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Contrast Media; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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23. Huang GS, Chang WC, Lee HS, Taylor JA, Cheng TY, Chen CY: Merkel cell carcinoma arising from the subcutaneous fat of the arm with intact skin. Dermatol Surg; 2005 Jun;31(6):717-9
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  • BACKGROUND: Merkel cell carcinoma is a rare malignant neuroendocrine neoplasm characteristically arising from the dermis of sunlight-exposed skin.
  • RESULTS: Histopathologic examination confirmed the diagnosis of Merkel cell carcinoma with local lymphatic metastasis, and the lesion was completely located in the subcutaneous fat, with no involvement of the dermis.
  • [MeSH-major] Carcinoma, Merkel Cell / diagnosis. Neoplasms, Adipose Tissue / surgery. Skin Neoplasms / diagnosis

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  • (PMID = 15996429.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Femia A, Klein PA: Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist. Dermatol Online J; 2010;16(4):15
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  • Lipomas are common benign neoplasms of adipose tissue.
  • [MeSH-major] Diabetes Mellitus, Type 2 / drug therapy. Hypoglycemic Agents / adverse effects. Lipoma / chemically induced. Neoplasms, Multiple Primary / chemically induced. PPAR gamma / agonists. Skin Neoplasms / chemically induced. Thiazolidinediones / adverse effects
  • [MeSH-minor] Adipose Tissue / drug effects. Aged. Female. Humans. Iatrogenic Disease

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  • (PMID = 20409422.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoglycemic Agents; 0 / PPAR gamma; 0 / Thiazolidinediones; X4OV71U42S / pioglitazone
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25. Li T, Wang L, Yu HH, Sun HC, Qin LX, Ye QH, Fan J, Tang ZY: Hepatic angiomyolipoma: a retrospective study of 25 cases. Surg Today; 2008;38(6):529-35
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  • PURPOSE: We report our experience of diagnosing and treating hepatic angiomyolipoma (HAML), a rare benign mesenchymal tumor.
  • All tumors were composed of varying proportions of smooth muscle, adipose tissue, and blood vessels, and showed positive immunohistochemical staining for HMB-45.
  • The definitive diagnosis of HAML is challenging and depends on the presence of HMB-45-positive myoid cells.
  • [MeSH-major] Angiomyolipoma / diagnosis. Angiomyolipoma / surgery. Liver Neoplasms / diagnosis. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Antigens, Neoplasm / analysis. Female. Hepatectomy. Humans. Magnetic Resonance Imaging. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / analysis. Prognosis. Retrospective Studies. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 18516533.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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26. Al-Zaid T, Alroy J, Pfannl R, Strissel KJ, Powers JF, Layer A, Carpinito G, Tischler AS: Oncocytic adrenal cortical tumor with cytoplasmic inclusions and hyaline globules. Virchows Arch; 2008 Sep;453(3):301-6
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  • [Title] Oncocytic adrenal cortical tumor with cytoplasmic inclusions and hyaline globules.
  • Adrenal cortical tumors, particularly oncocytic tumors, have been reported to contain a variety of intracytoplasmic and intramitochondrial inclusions.
  • Oncocytic cortical tumors can also morphologically mimic pheochromocytomas.
  • We report an unusual, partially oncocytic cortical neoplasm with nesting architecture, intranuclear inclusions, and hyaline globules reminiscent of pheochromocytoma, together with numerous, small, brightly eosinophilic, periodic acid-Schiff-positive cytoplasmic inclusions and typical cytoplasmic lipid droplets.
  • Immunohistochemistry and immunoblots were utilized to further characterize the tumor.
  • Immunohistochemistry demonstrated immunoreactivity of both the eosinophilic inclusions and the hyaline globules for adipose differentiation-related protein (ADRP), which is one of a group of proteins associated with storage of neutral lipids in many cell types.
  • Immunoblots confirmed the presence of ADRP and demonstrated an imbalance between ADRP and perilipin, another neutral lipid-associated protein, in tumor tissue compared to normal adrenal cortex.
  • The findings suggest that mitochondrial dysfunction in oncocytic cortical tumors may lead to abnormal processing of proteins related to the lipid-storing functions of the adrenal cortex, resulting in unusual cytoplasmic inclusions and extracellular globules resembling the globules in pheochromocytomas.
  • The finding of ADRP as a constituent of inclusions in adrenal cortical tumors has not been previously reported.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Inclusion Bodies / pathology. Oxyphil Cells / pathology

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  • (PMID = 18688642.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / PLIN2 protein, human; 0 / Perilipin-2
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27. Yao M, Huang Y, Shioi K, Hattori K, Murakami T, Nakaigawa N, Kishida T, Nagashima Y, Kubota Y: Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma. Clin Cancer Res; 2007 Jan 1;13(1):152-60
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  • [Title] Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma.
  • PURPOSE: We recently found that adipose differentiation-related protein (ADFP) is a potential diagnostic and prognostic biomarker for clear cell subtype renal cell carcinoma (RCC).
  • ADFP expression levels in the primary tumors and in 18 metastases were measured by real-time quantitative PCR.
  • The clinicopathologic and prognostic data were collected, as well as the von Hippel-Lindau disease (VHL) gene alteration status in selected cases.
  • RESULTS: ADFP expression was apparently high in cases without a symptomatic presentation, as well as in cases of low-stage, low-grade, or VHL alteration-positive clear cell RCC, whereas it was down-regulated in undifferentiated tumors with a spindle/pleomorphic component or metastatic lesions.
  • Further Cox multivariate analyses combined with the split-sample validation method showed that ADFP expression still remains an independent predictor for cancer-specific survival in all tumor stages and in advanced metastatic cases, whereas the predictive value of ADFP expression for cancer recurrence is rather weak.
  • CONCLUSIONS: The ADFP expression may represent the tumor differentiation status, and the detection of the expression levels provides useful prognostic information for cancer-specific survival in patients with clear cell RCC.
  • [MeSH-major] Adipose Tissue / metabolism. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / mortality. Gene Expression Regulation, Neoplastic. Kidney Neoplasms / metabolism. Kidney Neoplasms / mortality. Membrane Proteins / biosynthesis. Membrane Proteins / physiology. Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Differentiation. Disease Progression. Disease-Free Survival. Humans. Middle Aged. Multivariate Analysis. Neoplasm Metastasis. Prognosis. Proportional Hazards Models


28. Park CC, Rembert J, Chew K, Moore D, Kerlikowske K: High mammographic breast density is independent predictor of local but not distant recurrence after lumpectomy and radiotherapy for invasive breast cancer. Int J Radiat Oncol Biol Phys; 2009 Jan 1;73(1):75-9
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  • [Title] High mammographic breast density is independent predictor of local but not distant recurrence after lumpectomy and radiotherapy for invasive breast cancer.
  • Tissue components, including extracellular matrix, could confer resistance to ionizing radiation.
  • Fibroglandular and extracellular matrix components of breast tissue relative to adipose tissue can be quantified by the mammographic breast density (MBD), the proportion of dense area relative to the total breast area on mammography.
  • METHODS AND MATERIALS: We conducted a nested case-control study of 136 women with invasive breast cancer who had undergone BCS and RT and had had the MBD ascertained before, or at, diagnosis.
  • Women with known recurrence were matched to women without recurrence by year of diagnosis.
  • RESULTS: Patients with a high MBD (>/=75% density) vs. low (</=25%) were at increased risk of LRR (hazard ratio, 4.30; 95% confidence interval, 0.88-021.0; p = 0.071) but not distant recurrence.
  • [MeSH-major] Breast Neoplasms / epidemiology. Breast Neoplasms / radiography. Mammography / statistics & numerical data. Mastectomy, Segmental / statistics & numerical data. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / radiography. Radiotherapy / statistics & numerical data. Risk Assessment / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy / statistics & numerical data. Female. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Invasiveness. Prognosis. Reproducibility of Results. Risk Factors. San Francisco / epidemiology. Sensitivity and Specificity. Treatment Outcome


29. Bassett MD, Schuetze SM, Disteche C, Norwood TH, Swisshelm K, Chen X, Bruckner J, Conrad EU 3rd, Rubin BP: Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classification and prognostication. Cancer; 2005 Jan 15;103(2):409-16
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  • [Title] Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classification and prognostication.
  • BACKGROUND: Intramuscular lipomas and atypical lipomatous tumors (ALT) are common deep-seated lipomatous tumors of the chest wall and extremities.
  • Correct classification is important, because aggressive local disease recurrence occurs more frequently in patients with ALT than in patients with intramuscular lipoma.
  • METHODS: In the current study, 106 patients with deep-seated, well differentiated adipose tumors of the chest wall and extremities were classified as having ALT or intramuscular lipoma using a combined approach of histology and cytogenetics, if available.
  • Classification did not correlate with age and gender (P = 0.28 and P = 0.96, respectively).
  • Four percent of patients with intramuscular lipomas and 27% of patients with ALTs developed local disease recurrence (P = 0.0006).
  • Disease recurrence did not correlate with patient age at diagnosis, patient gender, tumor size, and tumor location (P = 0.45, P = 0.26, P = 0.49, and P = 0.28, respectively).
  • Within the subset of patients with ALTs, disease recurrence did not correlate with patient age at diagnosis, patient gender, or tumor location (P = 0.38, P = 0.54, and P = 0.86, respectively).
  • CONCLUSIONS: Classification of deep-seated, well differentiated lipomatous tumors of the extremities and chest wall using a combined approach of histology and cytogenetics correlated well with biologic behavior/disease recurrence.
  • [MeSH-major] Liposarcoma / genetics. Liposarcoma / pathology. Neoplasm Recurrence, Local / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Cohort Studies. Cytogenetics. Female. Humans. Immunohistochemistry. Incidence. Lower Extremity. Male. Middle Aged. Neoplasm Staging. Probability. Prognosis. Registries. Sensitivity and Specificity. Sex Distribution. Upper Extremity

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  • [Copyright] (c) 2004 American Cancer Society.
  • (PMID = 15593324.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Arai S, Matsushita A, Du K, Yagi K, Okazaki Y, Kurokawa R: Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. FEBS Lett; 2007 Dec 11;581(29):5649-57
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  • We describe here the cloning and characterization of a novel mouse homeodomain-interacting protein kinase (HIPK)-like gene, Hipk4.
  • Hipk4 is expressed in lung and in white adipose tissue and encodes a 616 amino acid protein that includes a serine/threonine kinase domain.
  • Human BCL2-associated X protein-promoter activity was not affected.
  • [MeSH-major] Protein-Serine-Threonine Kinases / metabolism. Serine / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Amino Acid Sequence. Animals. Catalysis. Cell Differentiation. Cell Proliferation. Cloning, Molecular. DNA, Complementary / metabolism. Humans. Inhibitor of Apoptosis Proteins. Mice. Microtubule-Associated Proteins / genetics. Microtubule-Associated Proteins / metabolism. Molecular Sequence Data. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Promoter Regions, Genetic. Sequence Alignment. bcl-2-Associated X Protein / genetics. bcl-2-Associated X Protein / metabolism

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  • (PMID = 18022393.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / BIRC5 protein, human; 0 / DNA, Complementary; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein; 452VLY9402 / Serine; EC 2.7.11.1 / HIPK4 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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31. Witt PM, Christensen JH, Schmidt EB, Dethlefsen C, Tjønneland A, Overvad K, Ewertz M: Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark. Cancer Causes Control; 2009 Nov;20(9):1715-21
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  • [Title] Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark.
  • OBJECTIVE: The aim of this study was to investigate the association between the content of marine n-3 polyunsaturated fatty acids (PUFA) in adipose tissue, a biomarker for the long-term intake of seafood, and the subsequent development of breast cancer (BC).
  • DESIGN: We designed a case-cohort study based on a cohort of healthy Danish women, who in the 1990 s donated adipose tissue biopsies to a biobank in order to investigate the role of diet for the development of cancer and chronic disease.
  • During follow-up, incident cases of BC were identified through national registries, and the content of n-3 PUFA in adipose tissue was compared between cases and the cohort sample.
  • CONCLUSION: This study does not indicate any association between the content of total or individual marine n-3 PUFA in adipose tissue and development of BC.
  • [MeSH-major] Adipose Tissue / chemistry. Biomarkers, Tumor / analysis. Breast Neoplasms / chemistry. Fatty Acids, Omega-3 / analysis
  • [MeSH-minor] Aged. Case-Control Studies. Denmark. Female. Humans. Middle Aged. Neoplasm Staging. Risk Factors

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  • (PMID = 19711189.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fatty Acids, Omega-3
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32. Basten O, Bandorski D, Bismarck C, Neumann K, Fisseler-Eckhoff A: [Acetone compression. A fast, standardized method to investigate gastrointestinal lymph nodes]. Pathologe; 2010 May;31(3):218-24
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  • Lymph node staging is the most important prognostic parameter in malignant gastrointestinal tumors.
  • Manual dissection of adipose tissue is time-consuming and also depends on the experience of the individual examiner.
  • By combining elution with acetone and mechanical compression using simple equipment it was possible to completely embed adipose tissue from 404 surgical specimens (colon 348, stomach 28, greater omentum 14, other location 14) without manual dissection.
  • As a result of the procedure, the weight of the adipose tissue could be reduced by 90%-95%, making full histological examination possible.
  • Elution with acetone enables the prompt, standardized and full histological work-up of adipose tissue without manual dissection.
  • [MeSH-major] Acetone. Gastrointestinal Neoplasms / pathology. Lymph Nodes / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Colonic Neoplasms / pathology. Humans. Immunohistochemistry / methods. Neoplasm Staging / methods. Prognosis. Stomach Neoplasms / pathology

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  • (PMID = 20012620.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 1364PS73AF / Acetone
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33. Pakos EE, Gogou PV, Apostolikas N, Batistatou A, Tsekeris PG: Factors associated with outcome in liposarcomas of the extremities and trunk. J BUON; 2010 Jul-Sep;15(3):518-23
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  • PURPOSE: Liposarcomas are malignant tumors that arise from primitive mesenchymal cells rather than mature adipose tissue.
  • In univariate analysis factors that were significantly associated with outcomes were grade III tumors, amputation procedures, use of chemotherapy and development of local recurrences.
  • The development of metastases is observed within the first 5-years from diagnosis.
  • Metastatic disease after that period is rare.
  • The possibility of local recurrence is not negligible after the 5th year of follow up.
  • [MeSH-major] Liposarcoma / mortality. Soft Tissue Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Extremities. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Proportional Hazards Models. Retrospective Studies. Risk Factors. Survival Rate

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  • (PMID = 20941821.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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34. Kuhnen C, Mentzel T, Lehnhardt M, Homann HH, Sciot R, Debiec-Rychter M: [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition]. Pathologe; 2010 Mar;31(2):129-34
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  • [Title] [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition].
  • [Transliterated title] Lipom und atypischer lipomatöser Tumor innerhalb einer Neoplasie: Hinweis für einen kontinuierlichen Ubergang.
  • The case of a lipomatous tumor with a predominant lipoma component and transition to an atypical lipomatous tumor is presented.
  • A deep-seated soft tissue tumor of the right thigh with a maximum size of 14 cm was resected in a 70-year-old female patient.
  • In the remaining portion (approximately 20%) histopathology showed an atypical lipomatous tumor (ALT, lipoma-like subtype).
  • Interphase dual-color fluorescence in situ hybridization showed no amplification of the MDM 2 gene and rarely CDK4 gene amplification within the lipoma component, but high level amplification of MDM 2/CDK4 gene in the ALT area, further supporting the morphologically based diagnosis of a lipomatous tumor including areas of a true lipoma and ALT.
  • This case underlines the concept of a continuous stepwise development of lipomatous soft tissue tumors from benign to malignant counterparts as a biological continuum.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. In Situ Hybridization, Fluorescence. Proto-Oncogene Proteins c-mdm2 / genetics. Thigh

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  • (PMID = 20063101.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.3.2.27 / MDM2 protein, human; EC 2.3.2.27 / Proto-Oncogene Proteins c-mdm2; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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35. Miscusi G, di Gioia CR, Patrizi G, Gravetz A, Redler A, Petrozza V: Anatomical lymph node mapping in normal mesorectal adipose tissue. Dis Colon Rectum; 2010 Dec;53(12):1640-4
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  • [Title] Anatomical lymph node mapping in normal mesorectal adipose tissue.
  • The adipose tissue was separated from the rectum and divided into 9 sections before fixing the specimen in paraffin, cutting into smaller portions, and staining with hematoxylin and eosin.
  • [MeSH-major] Adipose Tissue / anatomy & histology. Lymph Nodes / anatomy & histology. Rectum / anatomy & histology
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Cadaver. Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging / methods. Rectal Neoplasms / pathology. Staining and Labeling

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  • (PMID = 21178858.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Trahan S, Erickson-Johnson MR, Rodriguez F, Aubry MC, Cheville JC, Myers JL, Oliveira AM: Formation of the 12q14-q15 amplicon precedes the development of a well-differentiated liposarcoma arising from a nonchondroid pulmonary hamartoma. Am J Surg Pathol; 2006 Oct;30(10):1326-9
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  • [Title] Formation of the 12q14-q15 amplicon precedes the development of a well-differentiated liposarcoma arising from a nonchondroid pulmonary hamartoma.
  • Pulmonary hamartoma is a benign neoplasm that rarely recurs or undergoes malignant transformation.
  • Herein, we report a 48-year-old woman with a history of an incomplete excised nonchondroid pulmonary hamartoma presenting as an indolent tumor recurrence.
  • Excision of the tumor revealed a well-differentiated liposarcoma arising from the hamartomatous component.
  • These findings suggest that the formation of the 12q14-q15 chromosome amplicon, the characteristic cytogenetic finding of well-differentiated liposarcomas and the structural genomic component of the supernumerary ring and giant rod chromosomes, occurred before the morphologic changes characteristic of these malignant adipose tissue tumors and likely represents a very early molecular event in their development.
  • [MeSH-major] Chromosomes, Human, Pair 12. Gene Amplification. Hamartoma / genetics. Liposarcoma / genetics. Lung Neoplasms / genetics

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  • (PMID = 17001166.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / HMGA2 Protein; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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82. Kurita H, Kamata T, Koike T, Kobayashi H, Kurashina K: Intraoperative tissue staining of invaded oral carcinoma. Pathol Oncol Res; 2008 Dec;14(4):461-5
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  • [Title] Intraoperative tissue staining of invaded oral carcinoma.
  • The purpose of this study was to assess the ability of intraoperative tissue staining with consecutive application of 0.4% indigo carmine and 0.5% Congo red to demonstrate the extent and border of oral carcinoma invasion.
  • Once the oral tumor was resected, a vertical section of surgical specimen was taken from the central part of the tumor.
  • The extent and border of the invaded carcinoma were assessed on digital microscopic examination with tissue staining.
  • Tissue staining produced a brown-black stain on normal muscle, connective, and salivary tissues but not tumor and epithelial tissues.
  • It clearly demonstrated the extent and border of tumor invasion in 13 of 17 patients (76.5%); however, detection of remnant vital tumor cells in scar tissue after neoadjuvant chemotherapy, and distinction between the tumor and adipose tissue scattered in the muscle tissue was difficult.
  • The results of this study showed that intraoperative tissue staining was a possible method in demonstrating the extent and border of carcinoma deeply invaded in the soft tissue and selecting the site for additional frozen section analysis, although the method needed some refinement.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neoplasm Staging / methods. Staining and Labeling / methods

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  • (PMID = 18575826.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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83. Aron M, Aydin H, Sercia L, Magi-Galluzzi C, Zhou M: Renal cell carcinomas with intratumoral fat and concomitant angiomyolipoma: potential pitfalls in staging and diagnosis. Am J Clin Pathol; 2010 Nov;134(5):807-12
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  • [Title] Renal cell carcinomas with intratumoral fat and concomitant angiomyolipoma: potential pitfalls in staging and diagnosis.
  • Intratumoral fat and angiomyolipomas (AMLs) occurring within renal cell carcinomas (RCCs) have rarely been reported but may be mistaken for tumor invasion into perinephric or renal sinus fat or misdiagnosed as tumor exhibiting sarcomatoid differentiation.
  • Intratumoral fat or AML at the periphery of RCC simulated the invasion into the fat, while the smooth muscle component of AML resembled spindle cell, or sarcomatoid, differentiation.
  • Our study highlights the potential pitfalls in staging and diagnosis when intratumoral fat or AML is found within RCC.
  • [MeSH-major] Adipose Tissue / pathology. Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Adult. Aged. Calcinosis / pathology. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 20959665.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Yoo C, Song C, Hong JH, Kim CS, Ahn H: Prognostic significance of perinephric fat infiltration and tumor size in renal cell carcinoma. J Urol; 2008 Aug;180(2):486-91; discussion 491
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  • [Title] Prognostic significance of perinephric fat infiltration and tumor size in renal cell carcinoma.
  • Therefore, we evaluated the influence of perinephric fat infiltration and tumor size on patient survival.
  • Univariate and multivariate analyses of prognostic factors, including perinephric fat infiltration, on cancer specific and disease-free survival were performed.
  • RESULTS: Patients with pT1-2 and pT3a tumors had a 5-year cancer specific survival rate of 96.1% and 84.9%, and a 5-year disease-free survival rate of 93.4% and 74.7%, respectively (each p <0.01).
  • Age, tumor size and Fuhrman nuclear grade were independent prognostic factors for cancer specific and disease-free survival, whereas perinephric fat infiltration was significant only for disease-free survival.
  • However, perinephric fat infiltration had a significant effect on cancer specific survival in patients with pT3a tumors more than 7 cm (p = 0.001).
  • In contrast, patients with pT3a tumors 7 cm or less had cancer specific and disease-free survival similar to that of patients with pT2 tumors.
  • Recurrence of pT3a tumors greater than 7 cm was observed in 44% of patients but in only 14.6% of those with pT3a tumors 7 cm or less (p = 0.029).
  • In contrast to the recurrence of tumors 7 cm or less, recurrence of pT3a tumors more than 7 cm usually developed at multiple sites with a large tumor burden and it progressed rapidly.
  • Consequently 85% of patients with recurrence of pT3a tumors larger than 7 cm died of renal cell carcinoma compared with 33% of those with recurrence of pT3a tumors 7 cm or less (p = 0.001).
  • CONCLUSIONS: In pT3a renal cell carcinoma tumor size was the strongest prognostic factor of disease-free and cancer specific survival.
  • Perinephric fat infiltration was an independent prognostic factor for disease-free survival but not for cancer specific survival due to the less aggressive behavior of small (7 cm or less) pT3a tumors after recurrence.
  • Tumor size and perinephric fat infiltration should be included in T3a renal cell carcinoma staging.
  • [MeSH-major] Adipose Tissue / pathology. Carcinoma, Renal Cell / mortality. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / mortality. Kidney Neoplasms / pathology. Tumor Burden
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Cause of Death. Cohort Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Nephrectomy / methods. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Reference Values. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 18550101.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Ilie M, Hofman V, Pedeutour F, Attias R, Santini J, Hofman P: Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis. Pathol Res Pract; 2010 Jan 15;206(1):66-72
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  • Salivary gland oncocytic lipoadenoma is an exceptional benign tumor composed of mature adipose tissue associated with a mixture of oncocytes.
  • We report a case of oncocytic lipoadenoma showing sebaceous differentiation, and provide a cytogenetic analysis, which has not yet been described.
  • A 64-year-old male developed a left parotid gland, well-encapsulated tumor measuring 3.5 x 3 cm(2), showing mature fat cells associated with oncocytic changes of epithelial components.
  • Immunohistochemistry showed a dual epithelial population with ductal (positivity for AE1/AE3, CK19, CK7 antibodies) and basal-cell (positivity for p63, CK14, CK5,6 antibodies) differentiation in oncocytic areas.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Disease-Free Survival. Humans. Immunohistochemistry. Lipoma / metabolism. Lipoma / pathology. Lipoma / surgery. Male. Middle Aged. Neoplasm Proteins / metabolism

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19346081.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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86. Almeida J, Mesquita M, Ferraz J, Yamanaka A, Escanhoela C, Boin IF, Pereira G, Pereira T, Soares E: Hepatocellular carcinoma developing at the puncture site after percutaneous ethanol injection. J Clin Ultrasound; 2008 Feb;36(2):105-7
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  • We report a case of tumor seeding along the needle tract following PEI treatment for HCC arising 21 months after treatment.
  • [MeSH-major] Carcinoma, Hepatocellular / secondary. Ethanol / administration & dosage. Injections, Intralesional / adverse effects. Liver Neoplasms / ultrasonography. Neoplasm Seeding. Neoplasms, Adipose Tissue / secondary. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Anti-Infective Agents, Local / administration & dosage. Anti-Infective Agents, Local / adverse effects. Diagnosis, Differential. Follow-Up Studies. Humans. Middle Aged

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17960825.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Local; 3K9958V90M / Ethanol
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87. Kim HJ, Byun JH, Park SH, Shin YM, Kim PN, Ha HK, Lee MG: Focal fatty replacement of the pancreas: usefulness of chemical shift MRI. AJR Am J Roentgenol; 2007 Feb;188(2):429-32
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  • [Title] Focal fatty replacement of the pancreas: usefulness of chemical shift MRI.
  • OBJECTIVE: The purpose of this study was to describe the typical CT and chemical shift MRI findings and to evaluate their usefulness in the diagnosis of focal fatty replacement of the pancreas in five patients.
  • CONCLUSION: The presence of a perceptible focal low-attenuation lesion in the pancreas on CT and the reduction in signal intensity of the lesion on the opposed phase of chemical shift MR images are useful for differentiating focal fatty replacement of the pancreas from true pancreatic neoplasm.
  • Therefore, these imaging findings obviate invasive diagnostic procedures and surgery in the care of patients with focal fatty replacement of the pancreas.
  • [MeSH-major] Adipose Tissue / pathology. Lipomatosis / diagnosis. Magnetic Resonance Imaging / methods. Pancreatic Diseases / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17242252.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Kresowik TP, Johnson MT, Joudi FN: Combined renal sinus fat and perinephric fat renal cell carcinoma invasion has a worse prognosis than either alone. J Urol; 2010 Jul;184(1):48-52
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  • Patients with von Hippel-Lindau disease were excluded from study.
  • Cox logistic regression analysis was used to control for metastatic disease, tumor size and renal vein involvement to determine differences among the groups.
  • [MeSH-major] Adipose Tissue / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Prognosis. Proportional Hazards Models. Renal Veins / pathology. Survival Rate

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  • [Copyright] Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20478592.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Mojallal A, Saint-Cyr M, Garrido I: Autologous fat transfer: controversies and current indications for breast surgery. J Plast Reconstr Aesthet Surg; 2009 May;62(5):708-10
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  • [MeSH-major] Adipose Tissue / transplantation. Breast Neoplasms / surgery. Mammaplasty / methods
  • [MeSH-minor] Algorithms. Cell Transformation, Neoplastic. Female. Humans. Neoplasm Recurrence, Local / etiology

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  • [CommentOn] J Plast Reconstr Aesthet Surg. 2008 Dec;61(12):1438-48 [18848513.001]
  • (PMID = 19250897.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Netherlands
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90. Talwalkar SS, Shaheen SP 2nd: Extra-adrenal myelolipoma in the renal hilum: a case report and review of the literature. Arch Pathol Lab Med; 2006 Jul;130(7):1049-52
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  • We report a myelolipoma presenting as a localized mass in perirenal adipose tissue juxtaposed to the renal hilum in a 65-year-old Caucasian man who presented with back pain, weight loss, hematuria, and flank pain.
  • However, histology revealed mainly mature adipose tissue along with multiple scattered islands of hematopoietic precursor cells.
  • Perirenal masses such as morphologically identified myelolipomas are rarely, if ever, considered in differential diagnosis.
  • The purpose of this report is to elicit consideration of extra-adrenal myelolipoma when formulating a differential diagnosis for perirenal and retroperitoneal tumors.
  • Although primary and secondary malignant retroperitoneal tumors are much more common and aggressive neoplasms, establishing the correct diagnosis has important therapeutic and prognostic implications.
  • [MeSH-major] Adipose Tissue / pathology. Myelolipoma / pathology. Retroperitoneal Neoplasms / pathology
  • [MeSH-minor] Aged. Angiomyolipoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Transitional Cell / diagnosis. Diagnosis, Differential. Humans. Kidney Neoplasms / diagnosis. Lipomatosis / diagnosis. Liposarcoma / diagnosis. Male. Neoplasm Metastasis / diagnosis. Nephrectomy. Treatment Outcome

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  • (PMID = 16831034.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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91. Güvenç BH, Etus V, Muezzinoglu B: Lumbar teratoma presenting intradural and extramedullary extension in a neonate. Spine J; 2006 Jan-Feb;6(1):90-3
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  • Total removal of the tumor was achieved.
  • The pathological examination showed a benign teratoma containing mature cartilage, muscle, adipose tissue, and glandular tissue.
  • CONCLUSION: Accompanying a spinal dysraphic state, the mature teratoma in our case may support the idea of a tumor actually arising from a dysraphism and growing outward to produce the mass.
  • [MeSH-major] Lumbar Vertebrae. Neoplasm Invasiveness / pathology. Spinal Cord Neoplasms / diagnosis. Spinal Neoplasms / diagnosis. Teratoma / diagnosis
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Infant, Newborn. Magnetic Resonance Imaging. Neoplasm Staging. Neurosurgical Procedures / methods. Recovery of Function. Risk Assessment

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  • (PMID = 16413454.001).
  • [ISSN] 1529-9430
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Luebke T, Baldus SE, Zirbes TK, Pham TD, Schneider PM, Dienes HP, Hölscher AH, Mönig SP: Lymph node revealing solution in gastric carcinoma does not provide upstaging of the N-status. Oncol Rep; 2005 Feb;13(2):361-5
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  • [Title] Lymph node revealing solution in gastric carcinoma does not provide upstaging of the N-status.
  • However, very small lymph nodes can easily be missed during routine examination as they are obscured by the surrounding adipose tissue.
  • The purpose of the present study was to verify the usefulness of a lymph node revealing solution (LNRS) in gastric cancer and compare its accuracy concerning the detection of lymph node metastases to immunostaining with cytokeratin antibodies.
  • The remaining tissue was immersed for 24 h in LNRS.
  • The conventional preparation of lymph nodes from the unfixed tissue yielded a total of 452 lymph nodes (mean 41.1 lymph nodes/patient; range, 26 to 56), and 201 of them had a pN0 status.
  • After application of the LNRS lymph node analysis, it was not necessary to change the UICC node (N) stage in any cases.
  • In one patient, 10 micrometastases/disseminated tumour cells were detected.
  • By performing standardized LAD systematically and detailed lymph node preparation by the pathologist, a routine application of the LNRS method in gastric carcinoma is not recommended.
  • Immunohistochemical techniques aid in identifying micrometastatic disease in lymph nodes missed in routine H&E staining in order to define the pN(i) status according to the TNM classification.
  • [MeSH-major] Acetic Acid. Adenocarcinoma / pathology. Ethanol. Ether. Formaldehyde. Neoplasm Staging. Stomach Neoplasms / pathology
  • [MeSH-minor] Humans. Immunohistochemistry / methods. Keratins / immunology. Lymphatic Metastasis / diagnosis. Reproducibility of Results

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  • (PMID = 15643525.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / lymph node revealing solution; 0F5N573A2Y / Ether; 1HG84L3525 / Formaldehyde; 3K9958V90M / Ethanol; 68238-35-7 / Keratins; Q40Q9N063P / Acetic Acid
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93. Colella G, Biondi P, Caltabiano R, Vecchio GM, Amico P, Magro G: Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J; 2009;2:7906
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  • A 75-year-old Italian male presented at our department with a large tumor at the tip of the tongue that had been present for over 30 years.
  • Histological examination showed an unencapsulated lipomatous tumor composed of mature adipocytes, uniform in size and shape, diffusely infiltrating striated muscle fibers of the tongue.

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  • [Cites] J Oral Maxillofac Surg. 1991 Nov;49(11):1231-6 [1941342.001]
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  • (PMID = 19830025.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3302006
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94. Futagami A, Aoki M, Kawana S: A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue. Leuk Lymphoma; 2005 May;46(5):785-8
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  • [Title] A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue.
  • Histologically, the lesion showed a diffuse and dense infiltration of atypical lymphocytes extending from the superficial dermis to the subcutaneous tissue.
  • Severe lobular panniculitis, composed of small- and medium-sized atypical lymphocytes and large normal histiocytes, was observed in the subcutaneous adipose tissue.
  • [MeSH-major] Lymphoma, T-Cell, Peripheral / diagnosis. Neoplasm Regression, Spontaneous. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Blotting, Southern. Diagnosis, Differential. Humans. Immunohistochemistry. Immunophenotyping. Male. Skin / pathology. Subcutaneous Tissue / pathology

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  • (PMID = 16019520.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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95. Welsh SJ, Khan S: Radiological localizing techniques in adrenal tumors. Minerva Endocrinol; 2009 Jun;34(2):161-9
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  • [Title] Radiological localizing techniques in adrenal tumors.
  • We also discuss the radiological characteristics of rarer adrenal lesions including lymphoma, neuroblastic tumours (neuroblastoma, ganglioneuroblastoma, and ganglioneuroma), lipomatous tumours (myelolipoma, angiolipoma, teratoma, lipoma and liposarcoma), in addition to hemangioma, hemangiosarcoma and leiomyosarcoma.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Incidental Findings. Tomography, X-Ray Computed
  • [MeSH-minor] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Adrenocortical Carcinoma / radiography. Diagnosis, Differential. Ganglioneuroblastoma / radiography. Ganglioneuroma / radiography. Humans. Lymphoma / radiography. Magnetic Resonance Imaging. Neoplasm Metastasis. Neoplasms, Adipose Tissue / radiography. Neoplasms, Vascular Tissue / radiography. Neuroblastoma / radiography. Pheochromocytoma / radiography. Predictive Value of Tests. Sensitivity and Specificity. Teratoma / radiography

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  • (PMID = 19471240.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 42
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96. Bedke J, Buse S, Pritsch M, Macher-Goeppinger S, Schirmacher P, Haferkamp A, Hohenfellner M: Perinephric and renal sinus fat infiltration in pT3a renal cell carcinoma: possible prognostic differences. BJU Int; 2009 May;103(10):1349-54
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  • OBJECTIVE: To evaluate the influence of perinephric (PN) and renal sinus (RS) fat infiltration on cancer-specific survival beyond other prognostic factors, as the Tumour-Node-Metastasis (TNM) classification system defines stage T3a renal cell carcinoma (RCC) as infiltration of perirenal fat and/or direct infiltration of the adrenal gland.
  • Perirenal fat invasion is differentiated into RS and PN fat infiltration, but not further classified for the prognosis.
  • To identify prognostic effects of PN, RS or RS + PN fat infiltration, univariable and multivariable Cox proportional hazard regression models were applied, including lymph node status, metastases, presence of sarcomatoid features and tumour necrosis, Fuhrman's grade, Karnofsky performance status, and tumour size.
  • [MeSH-major] Adipose Tissue / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Nephrectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 19076147.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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97. Kawamoto S, Siegelman SS, Bluemke DA, Hruban RH, Fishman EK: Focal fatty infiltration in the head of the pancreas: evaluation with multidetector computed tomography with multiplanar reformation imaging. J Comput Assist Tomogr; 2009 Jan-Feb;33(1):90-5
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  • [Title] Focal fatty infiltration in the head of the pancreas: evaluation with multidetector computed tomography with multiplanar reformation imaging.
  • Fatty infiltration of the pancreas is generally a diffuse process; however, it may be unevenly distributed in the pancreas.
  • Focal fatty infiltration of the pancreas is usually most prominent in the anterior aspect of the head of the pancreas and seen as a region of decreased attenuation on computed tomography and may simulate pancreatic neoplasm.
  • We discuss and illustrate the various features of focal fatty infiltration of the pancreas on multidetector row helical computed tomography with multiplanar reformation images and show how this imaging modality helps to differentiate between focal fatty infiltration of the pancreas and actual pancreatic tumors.
  • [MeSH-major] Adipose Tissue / pathology. Adipose Tissue / radiography. Pancreas / radiography. Pancreatic Diseases / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19188793.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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98. Saldanha-Araujo F, Haddad R, Zanette DL, De Araujo AG, Orellana MD, Covas DT, Zago MA, Panepucci RA: Cancer/Testis antigen expression on mesenchymal stem cells isolated from different tissues. Anticancer Res; 2010 Dec;30(12):5023-7
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  • [Title] Cancer/Testis antigen expression on mesenchymal stem cells isolated from different tissues.
  • BACKGROUND/AIMS: The expression of cancer/testis antigens (CTAs) on additional normal tissues or stem cells may restrict their use as cancer targets.
  • The objective of the present study was to evaluate the mRNA levels of some CTAs in a variety of tissues.
  • MATERIALS AND METHODS: mRNA of pericytes, fibroblasts and mesenchymal stem cells (MSCs) derived from adult and fetal tissues, human umbilical vein endothelial cells, MSC-derived adipocytes, selected normal tissues and control cancer cell lines (CLs) were extracted and quantitative polymerase chain reaction was performed for MAGED1, PRAME, CTAG1B, MAGEA3 and MAGEA4.
  • RESULTS: MAGED1 was expressed in all normal tissues and cells evaluated.
  • CTAG1B was expressed at levels comparable to control CLs on MSCs derived from arterial, fetal skin, adipose tissue and saphenous vein, heart, brain and skin tissues.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Mesenchymal Stromal Cells / immunology
  • [MeSH-minor] Fibroblasts / immunology. Humans. Immunophenotyping. Melanoma-Specific Antigens. Membrane Proteins / biosynthesis. Neoplasm Proteins / biosynthesis. Pericytes / immunology

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  • (PMID = 21187485.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / MAGEA1 protein, human; 0 / MAGEA3 protein, human; 0 / MAGEA4 protein, human; 0 / MAGED1 protein, human; 0 / Melanoma-Specific Antigens; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / PRAME protein, human
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99. Aftab S, Casey A, Tirabosco R, Kabir SR, Saifuddin A: Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review. Skeletal Radiol; 2010 Oct;39(10):1039-42
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  • [Title] Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review.
  • Solitary fibrous tumour (SFT) is a rare soft tissue tumour of uncertain histogenesis and unpredictable biological behaviour, which was first described in the pleura and subsequently in many extra-pleural locations.
  • We present the clinical, radiological and histological features of a case of intraspinal fat-forming SFT, along with a literature review.
  • This is the first known report of a fat-forming SFT in the spine.
  • [MeSH-major] Solitary Fibrous Tumors / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hemangiopericytoma / diagnosis. Hemangiopericytoma / surgery. Humans. Lipoma / diagnosis. Lipoma / surgery. Magnetic Resonance Imaging / methods. Male. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20628877.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] Lipomatous hemangiopericytoma
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100. Mukai M, Nakamura M, Kishima K, Ninomiya H, Nomura N, Sato H, Kato N, Machida T, Nakasaki H, Makuuchi H: Local recurrence and occult neoplastic cells in the extranodal fat of dissected lymph nodes in patients with curatively resected primary colorectal cancer. Oncol Rep; 2007 Jun;17(6):1365-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adipose Tissue / pathology. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Lymph Nodes / pathology. Neoplasm Recurrence, Local / epidemiology

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
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  • (PMID = 17487392.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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