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Items 1 to 100 of about 139
1. Takahira T, Oda Y, Tamiya S, Yamamoto H, Kobayashi C, Izumi T, Ito K, Iwamoto Y, Tsuneyoshi M: Alterations of the RB1 gene in dedifferentiated liposarcoma. Mod Pathol; 2005 Nov;18(11):1461-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dedifferentiated liposarcoma is a malignant adipocytic neoplasm containing a non-lipogenic sarcoma of variable histological grade that arises against the background of a pre-existing well-differentiated liposarcoma.
  • The phenomenon of dedifferentiation is considered to be time-dependent, but the mechanism is not well known.
  • The retinoblastoma protein, encoded by the RB1 gene located at 13q14, is a key regulator of proliferation, development, and differentiation of certain cell types, including adipocytes.
  • [MeSH-major] Liposarcoma / genetics. Retinoblastoma Protein / genetics. Soft Tissue Neoplasms / genetics

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  • [Copyright] .Modern Pathology (2005) 18, 1454-1460. doi:10.1038/modpathol.3800444; published online 20 May 2005.
  • (PMID = 15933756.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein
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2. Arikawa S, Uchida M, Shinagawa M, Tohnan T, Hayabuchi N: Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst. Kurume Med J; 2006;53(1-2):37-40
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  • [Title] Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst.
  • Although a series of imaging studies suggested a lipomatous tumor, diagnosis was difficult because the tumor appeared as a pedunculated mass extending from the uterine body.
  • To distinguish the tumor from an ovarian lipomatous tumor, the "beak sign" in a magnetic resonance imaging study was diagnostic in this case.
  • The purpose of this paper is to review lipomatous masses of the female pelvis, to discuss the differential diagnosis of the unusual imaging features, and to discuss imaging techniques to optimize pelvic mass characterization.
  • [MeSH-major] Leiomyoma / diagnosis. Lipoma / diagnosis. Ovarian Cysts / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17043394.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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3. Honoki K, Morita K, Kasai T, Fujii H, Kido A, Tsukamoto S, Nonomura A, Tanaka Y: Hibernoma of the axillary region: a rare benign adipocytic tumor. Rare Tumors; 2010;2(1):e7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hibernoma of the axillary region: a rare benign adipocytic tumor.
  • Hibernoma is a rare benign tumor considered to arise from remnants of fetal brown adipose tissue.
  • Clinicallywell, hibernomas are slow-growing, asymptomatic tumors.
  • However, unlike lipomas, MRI findings sometimes mislead clinicians to diagnose a malignant neoplasm.

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  • (PMID = 21139952.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994483
  • [Keywords] NOTNLM ; adipocytic tumor / brown fat / hibernoma
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4. de Saint Aubain Somerhausen N, Coindre JM, Debiec-Rychter M, Delplace J, Sciot R: Lipoblastoma in adolescents and young adults: report of six cases with FISH analysis. Histopathology; 2008 Feb;52(3):294-8

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  • AIMS: Lipoblastoma is a rare benign adipocytic neoplasm that occurs primarily in infancy and early childhood.
  • Histologically, there is some morphological overlap with atypical lipomatous tumour and myxoid liposarcoma and the age at presentation is often regarded as a major diagnostic criterion.
  • CONCLUSIONS: Lipoblastoma occurs rarely in young adults and should enter into the differential diagnosis of 'atypical' fatty tumours in adults.
  • [MeSH-major] DNA, Neoplasm / analysis. In Situ Hybridization, Fluorescence. Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Adolescent. Adult. Chromosome Aberrations. Disease-Free Survival. Female. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 18269579.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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5. Mariño-Enríquez A, Fletcher CD, Dal Cin P, Hornick JL: Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol; 2010 Aug;34(8):1122-31
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  • [Title] Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria.
  • Dedifferentiated liposarcoma (LPS) is a malignant adipocytic neoplasm defined as the transition from well-differentiated LPS to a nonlipogenic sarcoma.
  • Heterologous differentiation is seen in 5% to 10% of dedifferentiated LPS, usually with myogenic or osteo/chondrosarcomatous elements.
  • Adipocytic differentiation in the dedifferentiated component is incompatible with the current definition of dedifferentiated LPS.
  • The tumors arose in the retroperitoneum (7), proximal lower extremity (3), chest wall (1), and neck (1) of 9 males and 3 females (median age 66 y; range 49 to 76).
  • Four cases were composed exclusively of pleomorphic LPS-like areas developing in 1 of the recurrences or metastases of a prior typical dedifferentiated LPS.
  • Two cases also showed heterologous smooth muscle differentiation.
  • Thus far, 5 patients have died of disease, 3 are alive with recurrent or metastatic disease, and 3 are alive with no evidence of disease.
  • We conclude that dedifferentiated LPS can show lipoblastic differentiation in the high-grade component, resulting in areas indistinguishable from pleomorphic LPS.
  • The available clinical and molecular data support the notion of "homologous" lipoblastic differentiation in dedifferentiated LPS, rather than mixed-type LPS.
  • [MeSH-major] Adipocytes / pathology. Biomarkers, Tumor. Cell Dedifferentiation. Liposarcoma / diagnosis
  • [MeSH-minor] Aged. Chromosomes, Human, Pair 12. Cyclin-Dependent Kinase 4 / analysis. Diagnosis, Differential. Female. HMGA2 Protein / genetics. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Karyotyping. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Predictive Value of Tests. Proto-Oncogene Proteins c-mdm2 / analysis. Terminology as Topic. Time Factors. Treatment Outcome

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  • (PMID = 20588177.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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6. Casanova Espinosa A, Cisneros Serrano C, Girón Moreno RM, Olivera MJ, Moreno Balsalobre R, Zamora García E: [Pleural empyema associated with endobronchial lipoma]. Arch Bronconeumol; 2005 Mar;41(3):172-4

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  • Bronchial benign tumors comprise fewer than 4% of pulmonary neoplasms.
  • Endobronchial lipoma is an extremely rare benign neoplasm accounting for only 0.1% to 0.5% of all lung tumors.
  • Clinical symptoms of lipoma depend on the location of the tumor, the severity of bronchial obstruction, and the functional and anatomical effects on the parenchyma distal to the obstruction.
  • Computed axial tomography usually reveals the adipose composition of the lipomatous tumor.
  • We report the case of an 83-year-old man diagnosed with community-acquired pneumonia that led to complications: pleural empyema caused by Haemophilus influenzae infection and atelectasis of the right middle and lower lobes secondary to a lipomatous endobronchial obstruction.
  • [MeSH-major] Bronchial Neoplasms / complications. Empyema, Pleural / etiology. Lipoma / complications

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  • (PMID = 15766470.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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7. Gokhale U, Pillai GR, Varghese PV, Samarsinghe D: Chondroid lipoma: a case report. Oman Med J; 2008 Apr;23(2):116-7

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  • Chondroid lipoma is a unique, uncommon benign lipomatous tumour.
  • We report such a neoplasm with brief a review of literature.

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  • (PMID = 22379550.001).
  • [ISSN] 1999-768X
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3282416
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8. Biernat W, Zakrzewski K, Polis L, Liberski PP: Glioneuronal-mesenchymal tumour with malignant transformation. Folia Neuropathol; 2007;45(3):140-3
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  • [Title] Glioneuronal-mesenchymal tumour with malignant transformation.
  • We report a case of a 10-year-old girl with a tumour of the right temporoparietal region of the brain.
  • The tumour consisted of three morphologically distinct portions: a well-differentiated one containing a mixture of a ganglioglioma with adipocytic-like cells and focal chondroid metaplasia, a separate island with neurocytic differentiation, and the malignant one, which exhibited an organoid pattern (trabecular and festooned) of primitive neuroectodemal tumour (PNET).
  • We hypothesize that the latter component originated from the multicomponental glioneuronal tumour with mesenchymal differentiation and thus that lesion constituted an unusual example of malignant transformation of low-grade glioneuronal neoplasm.

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  • (PMID = 17849365.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
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9. Obora A, Kojima T, Kato T, Matsuda H, Horie H, Hashimoto H, Fukuta N, Takano Y, Okuda J, Ida K, Saio M: [An autopsy case of hepatocellular carcinoma in which sarcoma-like changes and peritoneal dissemination were observed after RFA/TACE treatment]. Gan To Kagaku Ryoho; 2009 Jul;36(7):1183-6
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  • Liver biopsy led to a diagnosis of well-differentiated hepatocellular carcinoma.
  • CT revealed pleural effusion/ascites and nodular tumor in the adipose tissue of the parietal peritoneum and mesentery around the liver.
  • Autopsy revealed a tumor involving the liver surface to the peritoneum, suggesting cancerous peritonitis.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Catheter Ablation. Chemoembolization, Therapeutic. Liver Neoplasms / therapy

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  • (PMID = 19620814.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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10. Nishida J, Ehara S, Shiraishi H, Tada H, Satoh T, Okada K, Shimamura T: Clinical findings of hibernoma of the buttock and thigh: rare involvements and extremely high uptake of FDG-PET. Med Sci Monit; 2009 Jul;15(7):CS117-22

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  • BACKGROUND: Hibernoma is a rare adipose tissue tumor of the soft tissue and the term is derived from the histological similarities to the brown fat found in hibernating animals.
  • This was not typical of liposarcoma and suggestive of hibernoma.
  • Biopsy specimens revealed a proliferation of adipose cells with vacuolated granular eosinophilic cytoplasm.
  • CONCLUSIONS: While occurrences in the buttock or thigh are exceedingly rare, hibernoma should be included in the differential diagnosis of an adipose tissue tumor in the thigh, even though the imaging findings mimic liposarcoma.
  • A correct diagnosis should be established to prevent over-surgery.

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  • (PMID = 19564831.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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11. Kabasawa Y, Katsube K, Harada H, Nagumo K, Terasaki H, Perbal B, Okada N, Omura K: A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):677-82
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  • [Title] A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor.
  • METHODS: We examined morphological aspects of the tumor and immunohistochemical patterns.
  • RESULTS: Tumor proliferation was infiltrative, which did not show apparent encapsulation.
  • Positive immunoreactivity was found for CD-34, CD-99, Ki-67, and connective tissue growth factor/CCN2 in the fibrous region, S-100 in the adipose region, and Notch1 stain was observed in the eccrine sweat gland cells juxtaposed to the tumor adipose tissue, but no reactivity for Bcl-2, alphaSMA, Notch 2-4, CCN1, and CCN3.
  • Specific expression of CCN2 might be significant for the development of the tumor.
  • [MeSH-major] Fibroma / pathology. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Lipoma / pathology
  • [MeSH-minor] Adipose Tissue / chemistry. Adipose Tissue / pathology. Antigens, CD / analysis. Antigens, CD34 / analysis. Cell Adhesion Molecules / analysis. Connective Tissue Growth Factor. Humans. Immediate-Early Proteins / biosynthesis. Immunohistochemistry. Infant. Insulin-Like Growth Factor Binding Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Ki-67 Antigen / analysis. Male. Neoplasm Proteins / biosynthesis. Nephroblastoma Overexpressed Protein. Receptor, Notch1 / biosynthesis. S100 Proteins / analysis

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  • (PMID = 17466886.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / CTGF protein, human; 0 / Cell Adhesion Molecules; 0 / Immediate-Early Proteins; 0 / Insulin-Like Growth Factor Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / NOTCH1 protein, human; 0 / NOV protein, human; 0 / Neoplasm Proteins; 0 / Nephroblastoma Overexpressed Protein; 0 / Receptor, Notch1; 0 / S100 Proteins; 139568-91-5 / Connective Tissue Growth Factor
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12. Novikov VV, Novikov GV, Fesenko EE: Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics; 2009 Jul;30(5):343-51

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  • [Title] Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma.
  • It was shown that the exposure of mice with EAC to combined MFs causes structural changes in some organs (liver, adrenal glands), which are probably due to the total degradation of the tumor tissue.
  • In mice with transplanted EAC, the tumor tissue after exposure to weak MFs was practically absent, as distinct from control animals in which the invasion of the tumor into the adipose tissue surrounding the kidneys, mesenteric lymph nodes, and spermatic appendages was observed.
  • In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism.
  • [MeSH-major] Carcinoma, Ehrlich Tumor / pathology. Carcinoma, Ehrlich Tumor / therapy. Magnetic Field Therapy / methods. Magnetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19267367.001).
  • [ISSN] 1521-186X
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Kurita H, Kamata T, Koike T, Kobayashi H, Kurashina K: Intraoperative tissue staining of invaded oral carcinoma. Pathol Oncol Res; 2008 Dec;14(4):461-5
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  • [Title] Intraoperative tissue staining of invaded oral carcinoma.
  • The purpose of this study was to assess the ability of intraoperative tissue staining with consecutive application of 0.4% indigo carmine and 0.5% Congo red to demonstrate the extent and border of oral carcinoma invasion.
  • Once the oral tumor was resected, a vertical section of surgical specimen was taken from the central part of the tumor.
  • The extent and border of the invaded carcinoma were assessed on digital microscopic examination with tissue staining.
  • Tissue staining produced a brown-black stain on normal muscle, connective, and salivary tissues but not tumor and epithelial tissues.
  • It clearly demonstrated the extent and border of tumor invasion in 13 of 17 patients (76.5%); however, detection of remnant vital tumor cells in scar tissue after neoadjuvant chemotherapy, and distinction between the tumor and adipose tissue scattered in the muscle tissue was difficult.
  • The results of this study showed that intraoperative tissue staining was a possible method in demonstrating the extent and border of carcinoma deeply invaded in the soft tissue and selecting the site for additional frozen section analysis, although the method needed some refinement.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neoplasm Staging / methods. Staining and Labeling / methods

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  • (PMID = 18575826.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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14. Marsilia GM, Boscaino A, La Mura A, Ceriello A, De Ritis R: Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? Int J Surg Pathol; 2010 Dec;18(6):537-9
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  • Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45.
  • The tumor cells of intramural small intestinal mass were positive for S-100 protein and GFAP and negative for CD117, CD34 and desmin.
  • [MeSH-major] Angiomyolipoma / pathology. Jejunal Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19282295.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. de Groot M, Appelman M, Spuls PI, de Rie MA, Bos JD: Initial experience with routine administration of etanercept in psoriasis. Br J Dermatol; 2006 Oct;155(4):808-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: We hypothesized: (i) that efficacy would be lower than that obtained in published phase II and III studies because (a) resistance to all conventional therapies as a reimbursement condition would select for more resistant cases and (b) inclusion would be more restricted to severe cases (higher PASI), and (ii) that efficacy would be lower in obese patients due to the possible role of adipose tissue in tumour necrosis factor (TNF)-alpha homeostasis.
  • Additionally, we related the clinical effect to the body mass index (BMI), for adipose tissue is thought to have a possible role in TNF-alpha homeostasis.
  • Although fatigue is not identified as a side-effect of etanercept, 10% of our patients reported fatigue as an adverse event during etanercept treatment.
  • Finally, the BMI does not seem to influence the patients' response to etanercept, although further investigations would be needed to confirm this.
  • [MeSH-major] Dermatologic Agents / therapeutic use. Immunoglobulin G / therapeutic use. Psoriasis / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use

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  • (PMID = 16965432.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; OP401G7OJC / Etanercept
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16. Carroll PA, Healy L, Lysaght J, Griffin M, Dunne B, Boyle MT, Reynolds JV, Kennedy MJ, Pidgeon G, Connolly EM: Mammary adipose tissue and cancer cell growth: The role of adipose tissue in the tumor microenvironment. J Clin Oncol; 2009 May 20;27(15_suppl):e22009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary adipose tissue and cancer cell growth: The role of adipose tissue in the tumor microenvironment.
  • Adipose tissue is considered an important endocrine organ producing several important hormones and cytokines including leptin and adiponectin.
  • Mechanisms for the role of obesity in cancer states includes the excess or unregulated secretion of adipocytokines from adipose tissue, and potentially the metabolic syndrome (a cluster of co-morbidities linked to metabolic dysregulation).
  • Mammary adipose tissue is proposed to play a vital role in the microenvironment of normal and tumour states within the breast<sup>2</sup>.
  • Breast adipose tissue is a good candidate to investigate effects of obesity and metabolic disturbances on cancer states.
  • METHODS: Peritumoural (PT) adipose tissue adjacent to the tumour and distal adipose tissue (D) within the breast was sampled in 10 patients.
  • The tissue was processed and cultured for 72hrs in serum free minimal cytokine media.
  • The adipocytokine profile at the mRNA and protein level was measured in ACM and adipose tissue for comparative differences using RT-PCR, ELISA and Cytokine Profiler technology.
  • RESULTS: ACM from both sites promoted tumour cell survival.
  • This may be mediated through increased pro-inflammatory or pro- mitogenic adipocytokine production in adipose tissue surrounding tumour.

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  • (PMID = 27963182.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Kubo T, Matsui Y, Naka N, Araki N, Myoui A, Endo K, Yasui N, Ohtani O, Suzuki K, Kimura T, Yoshikawa H, Ueda T: Specificity of fusion genes in adipocytic tumors. Anticancer Res; 2010 Feb;30(2):661-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Specificity of fusion genes in adipocytic tumors.
  • BACKGROUND: In subsets of adipocytic tumors, specific chromosomal translocations lead to the generation of fusion genes.
  • However, the specificity of these fusion genes has not been established in a variety of adipocytic tumors.
  • PATIENTS AND METHODS: One hundred and seventy-two cases of adipocytic tumors, comprising 98 cases of lipoma and 74 cases of liposarcoma, were analyzed for the possible expression of HMGA2-LPP, LPP-HMGA2, TLS-CHOP and EWS-CHOP fusion genes, using a reverse-transcription polymerase chain reaction method.
  • [MeSH-minor] Cell Differentiation. Humans. Neoplasm Staging. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Retrospective Studies. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20332486.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DDIT3 protein, human; 0 / HMGA Proteins; 0 / HMGA2-LPP fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / RNA-Binding Protein EWS; 0 / RNA-Binding Protein FUS; 0 / TLS-CHOP fusion protein, human; 147336-12-7 / Transcription Factor CHOP
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18. Hameed M: Pathology and genetics of adipocytic tumors. Cytogenet Genome Res; 2007;118(2-4):138-47
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  • [Title] Pathology and genetics of adipocytic tumors.
  • Adipocytic tumors are common mesenchymal neoplasms with considerable morphologic and genetic heterogeneity.
  • The fruitful integration of morphology and cytogenetics in the past 15 years has not only enhanced the diagnostic accuracy, but also refined the various pathological classifications and subtypes in these tumors.
  • The current WHO classification includes eleven benign subtypes, one intermediate and five categories of malignant fatty neoplasms with incorporation of relevant genetic findings.
  • Of the benign tumors, lipomas have been extensively analyzed by chromosome banding which has shown that their cytogenetic patterns are heterogeneous.
  • Among the malignant tumors, the t(12;16)(q13;p11) resulting in the fusion of DDIT3 and FUS genes is the hallmark of myxoid and round cell liposarcoma and is used as a highly specific and sensitive marker of this entity.
  • The tumor in the intermediate group, atypical lipomatous neoplasm/well-differentiated liposarcoma which poses morphologic challenges due to close histological similarity to benign lipomas shows characteristic supernumerary rings and giant rod chromosomes due to amplification of the 12q14-->q15 region often involving the MDM2 oncogene.
  • This review will focus on the pathological features of the various adipocytic tumors and relevant genetic findings reported in the literature.
  • [MeSH-major] Adipocytes. Neoplasms / genetics. Neoplasms / pathology

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 18000364.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 76
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19. Ide F, Tanaka A, Kusama K: Further evidence for adipocytic differentiation by the neoplastic myoepithelium. J Oral Pathol Med; 2007 Mar;36(3):187-9
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  • [Title] Further evidence for adipocytic differentiation by the neoplastic myoepithelium.
  • Lipomatous pleomorphic adenoma (PA)/myoepithelioma is rare.
  • Nevertheless, adipocytic differentiation in salivary gland tumors is a well-known phenomenon.
  • We report here a unique PA that represents an equivocal transition from the epithelioid NME to adipocytes in recurrent lesions but not in a primary tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adipocytes / pathology. Epithelial Cells / pathology. Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 17305642.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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20. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • [Title] Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation.
  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years.
  • Four tumors predominantly showed features of schwannoma and one of neurofibroma; however, intimately admixed with the spindle cell population, there were also numerous scattered mature adipocytes as well as lipoblast-like cells displaying a signet-ring cell appearance.
  • The signet-ring cells were negative for mucin stains, cytokeratin, EMA, CEA, and several other differentiation markers.
  • The signet-ring cells contained large cytoplasmic lipid droplets that displaced the nuclei to the periphery, consistent with lipoblastic differentiation, whereas complex, interdigitating cytoplasmic processes covered by basal lamina material characteristic of nerve sheath differentiation could be identified in the spindle cells.
  • The presence of mature fat and signet-ring lipoblast-like cells within a nerve sheath neoplasm is quite rare and may signify a process of aberrant differentiation.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-major] Adipose Tissue / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • We present a rare atypical lipomatous tumour with spindle cell features (synonym: well-differentiated spindle cell liposarcoma) arising on the left palm of a 54-year-old male patient.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • However, focally, atypia of adipocytic and stromal cells as well as scattered lipoblasts were noted, and immunohistochemical stainings showed focal overexpression of MDM 2 and CDK4.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • [Cites] Virchows Arch. 1995;427(4):353-63 [8548119.001]
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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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22. Ma X, Ren X, Han P, Hu S, Wang J, Yin J: SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction. Mol Biol Rep; 2010 Dec;37(8):4003-11
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  • [Title] SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction.
  • Fatty acid-binding protein 5 (Fabp5), exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport.
  • 3T3-L1 preadipocytes were selected as cell differentiation model and short interfering RNAs (siRNA) against Fabp5 (siFabp5) were prepared.
  • However, during adipocytic induction, 3T3-L1 preadipocytes transfected with siFabp5 significantly reduced cell viability, as well as increased both caspase-3 activity and procaspase-3 cleavage.
  • Furthermore, we illustrated that knockdown Fabp5 inhibited the expression of PPARγ and C/EBPα during adipocytic induction.
  • [MeSH-major] Adipocytes / cytology. Adipocytes / metabolism. Apoptosis. Cell Differentiation. Fatty Acid-Binding Proteins / metabolism. Neoplasm Proteins / metabolism. RNA, Small Interfering / metabolism

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  • (PMID = 20238174.001).
  • [ISSN] 1573-4978
  • [Journal-full-title] Molecular biology reports
  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Protein-alpha; 0 / Fabp5 protein, mouse; 0 / Fatty Acid-Binding Proteins; 0 / Neoplasm Proteins; 0 / PPAR gamma; 0 / RNA, Messenger; 0 / RNA, Small Interfering; EC 3.4.22.- / Caspase 3
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23. Farah-Klibi F, Ferchichi L, Zaïri I, Rammeh S, Adouani A, Jilani SB, Zermani R: Lipomatous hemangiopericytoma (adipocytic variant of solitary fibrous tumor) of the orbit. A case report with review of the literature. Pathologica; 2006 Dec;98(6):645-8
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  • [Title] Lipomatous hemangiopericytoma (adipocytic variant of solitary fibrous tumor) of the orbit. A case report with review of the literature.
  • Hemangiopericytoma (HPC) of the orbit is a rare tumor presenting with slowly progressive proptosis, ocular motility impairment and visual loss.
  • In 1995, a newly variant of HPC termed lipomatous hemangiopericytoma (LHPC), was described.
  • The authors describe another case of orbital LHPC and discuss the clinicopathologic features, including the immunohistochemical staining profile and ultrastructural appearance of this distinctive tumor, and briefly discuss the relationship between HPC and solitary fibrous tumor of soft tissue, a neoplasm with many clinical and pathologic similarities.
  • [MeSH-major] Hemangiopericytoma / pathology. Lipoma / pathology. Orbital Neoplasms / pathology

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  • (PMID = 17285842.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 11
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24. Scariot R, Giovanini AF, Torres-Pereira CC, Piazzetta CM, Costa DJ, Rebellato NL, Müller PR: Massive growth of an intraoral lipoma. J Contemp Dent Pract; 2008;9(7):115-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Lipoma, a benign tumor of adipose tissue, is rarely seen in the oral cavity.
  • A clinical diagnosis of lipoma was established, and the treatment consisted of complete excision of the mass under local anesthesia.
  • [MeSH-major] Cheek / pathology. Lipoma / pathology. Mouth Neoplasms / pathology

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  • (PMID = 18997924.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Miyakura T, Irisawa R, Miyamoto M, Iwaya K, Yamamoto T, Tsuboi R: An atypical case of atypical lipomatous tumor. Am J Dermatopathol; 2008 Dec;30(6):590-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An atypical case of atypical lipomatous tumor.
  • Immunohistochemically, some of the tumor cells were positive for p53 and MDM2.
  • Histologically, the atypical lipomatous tumor, lipoblastoma, spindle cell lipoma, pleomorphic liposarcoma, and hibernoma comprised the list of possible, differential diagnoses.
  • We considered our case to be a variant of atypical lipomatous tumor, although it did not correspond to any of the 4 atypical lipomatous tumor subgroups.
  • [MeSH-major] Adipocytes / pathology. Liposarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Middle Aged. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19033936.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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26. Browne TJ, Fletcher CD: Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology; 2006 Mar;48(4):453-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity.
  • AIMS: To describe 13 new cases of a rare soft tissue neoplasm currently known as haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL) and to further its characterization.
  • Grossly the lesions were fatty/gelatinous or lipoma-like.
  • Dissecting between adipocytic lobules were septa containing short spindle cells with streaming, swirling or honeycomb growth patterns.
  • CONCLUSIONS: So-called HFHLL, better termed haemosiderotic fibrolipomatous tumour, is a distinct lesion characterized by an admixture of fibroblastic spindle cells, mature adipocytes and haemosiderin pigmentation, shows a predilection for the distal extremities and quite often recurs locally.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16487368.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 9011-92-1 / Hemosiderin
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27. Yalniz E, Alicioglu B, Oz Puyan F: Hibernoma: a benign lipomatous tumor mimicking liposarcoma. J BUON; 2008 Jan-Mar;13(1):127-9
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  • [Title] Hibernoma: a benign lipomatous tumor mimicking liposarcoma.
  • Hibernoma is a rare, benign, slow-growing soft tissue tumor.
  • Due to its rich vascularity and magnetic resonance appearance, this tumor may mimic a liposarcoma before tissue diagnosis.
  • Malignant potential has not been demonstrated.
  • The clinical presentation, radiographic and histopathologic features of this rare benign soft tissue tumor are presented.
  • This tumor is clinically important because it is indistinguishable from malignant lesions.
  • [MeSH-major] Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18404800.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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28. He M, Aisner S, Benevenia J, Patterson F, Aviv H, Hameed M: p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):51-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.
  • Atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive malignant mesenchymal neoplasm, resembling ordinary lipoma in many clinical aspects.
  • Fifty cases of lipomatous neoplasms, with cytogenetic results, from 45 patients were collected from the archives in Department of Pathology, University of Medicine and Dentistry of New Jersey/New Jersey Medical School during 1998 to 2006.

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  • (PMID = 18779733.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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29. Sadeghian H, Eslami B, Shirani S, Sadeghian A: Lipomatous tumor of the tricuspid valve: report of a rare case. J Heart Valve Dis; 2009 Nov;18(6):720-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous tumor of the tricuspid valve: report of a rare case.
  • The case is reported of a 19-year-old man with cardiac valve lipomatosis which was accidentally discovered during the work-up for an atypical chest pain.
  • Magnetic resonance imaging showed evidence of tricuspid valve lipomatosis, a rare cardiac valve tumor.
  • After five months, echocardiography showed that the mass had not grown.
  • To the best of the present authors' knowledge, very few reports exist of cardiac valve lipomatous tumors.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Lipoma / ultrasonography. Tricuspid Valve / ultrasonography

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  • (PMID = 20099724.001).
  • [ISSN] 0966-8519
  • [Journal-full-title] The Journal of heart valve disease
  • [ISO-abbreviation] J. Heart Valve Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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30. Yamaguchi T, Takimoto T, Yamashita T, Kitahara S, Omura M, Ueda Y: Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney. Urology; 2005 Jan;65(1):175
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney.
  • Fat-containing variant of a solitary fibrous tumor is a recently recognized benign soft-tissue tumor that usually affects the thigh and retroperitoneum.
  • We report a 51-year-old woman with a fat-containing variant of a solitary fibrous tumor that is the first reported case involving a visceral organ.
  • The tumor was well delineated and seemed to arise from the renal capsule, radiographically and macroscopically.
  • The tumor microscopically mimicked a solitary fibrous tumor but exhibited focal aggregates of fat cells.
  • A fat-containing variant of a solitary fibrous tumor involving the kidney should be distinguished from spindle cell carcinoma, angiomyolipoma, gastrointestinal stromal tumor, and cellular schwannoma.
  • [MeSH-major] Adipose Tissue / pathology. Hemangiopericytoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 15667897.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Cheng H, Dodge J, Mehl E, Liu S, Poulin N, van de Rijn M, Nielsen TO: Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays. Hum Pathol; 2009 Sep;40(9):1244-51
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  • [Title] Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays.
  • Expression profiling followed by tissue microarray validation linked to patient outcome is a powerful approach for validating biological mechanisms and identifying prognostic biomarkers.
  • We applied these techniques to independent series of primary myxoid liposarcomas in an effort to assess markers of adipose differentiation in myxoid liposarcoma and to identify prognostic markers that can be efficiently assessed by immunohistochemistry.
  • Candidate genes were selected based on analysis of expression profiles from 9 primary myxoid/round liposarcomas and 45 other soft tissue tumors, and by reference to publicly available data sets.
  • Protein products were validated on an adipose neoplasm tissue microarray, including 32 myxoid liposarcomas linked to patient outcome.
  • [MeSH-major] Adipogenesis. Biomarkers, Tumor / analysis. Liposarcoma, Myxoid / genetics. Soft Tissue Neoplasms / genetics. Tissue Array Analysis / methods

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  • (PMID = 19368956.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin-Like Growth Factor Binding Protein 2; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / Receptor, IGF Type 1
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32. Horton SC, Nay S, Gonzales M, McIntosh M, Hammond E, Clayson S: Smooth muscle neoplasm presenting as intrapericardial myxoma. J Am Soc Echocardiogr; 2006 Jun;19(6):835.e1-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Smooth muscle neoplasm presenting as intrapericardial myxoma.
  • The tumor was a globular mass attached to the left atrium by a stalk, suggestive of a myxoma.
  • Histology revealed a smooth muscle tumor with extensive adipocytic differentiation and numerous small blood vessels.
  • This study represents the first echocardiographic description of a smooth muscle tumor presenting as an extracardiac myxoma.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Muscle Neoplasms / ultrasonography. Muscle, Smooth, Vascular / ultrasonography. Myxoma / ultrasonography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 16762765.001).
  • [ISSN] 1097-6795
  • [Journal-full-title] Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
  • [ISO-abbreviation] J Am Soc Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Brandal P, Bjerkehagen B, Heim S: Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol; 2006 Feb;208(3):388-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology.
  • Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have different more or less specific chromosomal abnormalities.
  • One such entity is lipoblastoma, which is a benign lipomatous tumour that often exhibits rearrangements of chromosome bands 8q11-13, and the gene PLAG1 has been implicated as the target of these chromosomal changes.
  • All lipomatous tumours karyotyped at the Norwegian Radium Hospital were reviewed, looking for rearrangements of 8q11-13.
  • The findings raise the question as to what extent the diagnosis lipoblastoma should be based on histopathological or cytogenetic/molecular data or a combination thereof.
  • When karyotypic information from this series was combined with available literature data, it was found that the sensitivity of 8q11-13 rearrangements for diagnosing lipoblastomas when found in a lipomatous tumour was 77% and that the corresponding specificity was 98%.
  • The validity of these calculations of the diagnostic information provided by the cytogenetic findings is, of course, totally dependent on the morphological diagnosis made in each case.
  • Regardless of what the precise phenotypic diagnosis was, it is suggested that lipomatous tumours with 8q11-13 rearrangement constitute a distinct pathogenetic entity.
  • When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8. Gene Rearrangement. Lipoma / genetics. Neoplasms, Adipose Tissue / genetics

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  • (PMID = 16308870.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / PLAG1 protein, human
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34. Eberhardt M, Salmon P, von Mach MA, Hengstler JG, Brulport M, Linscheid P, Seboek D, Oberholzer J, Barbero A, Martin I, Müller B, Trono D, Zulewski H: Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets. Biochem Biophys Res Commun; 2006 Jul 7;345(3):1167-76
eagle-i research resources. PMID 16713999 (Special Collections) .

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  • In accordance with a mesenchymal phenotype, the cells were also able to adopt adipocytic or osteocytic phenotypes in vitro.
  • [MeSH-major] Homeodomain Proteins / physiology. Intermediate Filament Proteins / physiology. Islets of Langerhans / cytology. Mesenchymal Stromal Cells / cytology. Nerve Tissue Proteins / physiology
  • [MeSH-minor] ATP-Binding Cassette Transporters / metabolism. Adipocytes / metabolism. Albumins / metabolism. Cell Culture Techniques / methods. Cell Differentiation. Humans. LIM-Homeodomain Proteins. Lentivirus / metabolism. Neoplasm Proteins / metabolism. Nestin. Neurons / metabolism. Osteoblasts / metabolism. Transcription Factors

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  • (PMID = 16713999.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / Albumins; 0 / Homeodomain Proteins; 0 / Intermediate Filament Proteins; 0 / LIM-Homeodomain Proteins; 0 / NES protein, human; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / Transcription Factors; 0 / insulin gene enhancer binding protein Isl-1
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35. He M, Aisner S, Benevenia J, Patterson F, Harrison LE, Hameed M: Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma. Pathol Res Pract; 2009;205(6):386-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive subtype of liposarcoma unless dedifferentiation occurs.
  • The mechanism driving this progression is not clear.
  • Loss of p16 is believed to be an early and critical event in tumor progression.
  • Gene silencing by methylation of p16INK4a gene promoter has been reported in several soft tissue sarcomas.
  • The aim of this study is to study the role of p16INK4a gene promoter methylation and p16 expression in tumor progression (dedifferentiation) and recurrence of ALT/WDLPS.
  • The other two DDLPS and three recurrent WDLPS were not methylated.
  • All three recurrent WDLPS showed positive p16 expression with similar intensity between primary and recurrent tumors.
  • Even though linear correlation between p16 promoter hypermethylation and p16 protein expression was not present, there appears to be a role for p16INK4a gene promoter hypermethylation in DDLPS and not in recurrent WDLPS.
  • [MeSH-major] Cell Dedifferentiation / genetics. Epigenesis, Genetic. Genes, p16. Liposarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p16 / biosynthesis. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation / genetics. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Promoter Regions, Genetic / genetics. Proto-Oncogene Proteins c-mdm2 / biosynthesis. Retinoblastoma Protein / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 19186005.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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36. Willmore-Payne C, Holden J, Turner KC, Proia A, Layfield LJ: Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe. Arch Pathol Lab Med; 2008 Jun;132(6):952-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Amplifications occur within the 12q13-15 region of atypical lipomatous tumors and well-differentiated liposarcomas but not lipomas.
  • OBJECTIVE: To investigate the performance characteristics of the LSI CHOP Breakapart Rearrangement Probe for the diagnosis of myxoid/round cell liposarcomas and atypical lipomas/well-differentiated liposarcomas.
  • DESIGN: We investigated a series of lipomatous neoplasms (5 lipomas, 5 well-differentiated liposarcomas, 22 myxoid/round cell liposarcomas, 2 liposarcomas not otherwise specified, and 2 dedifferentiated liposarcomas) and normal myometrium for abnormalities in the q13-15 region of chromosome 12.
  • Cases were studied for the presence or absence of t(12;16)(q13;p11) or t(12;22)(q13;q12) translocations by the LSI CHOP Breakapart Rearrangement Probe.
  • Rearrangements were seen in 1 dedifferentiated liposarcoma but not in normal myometrium or lipomas.
  • The probe also demonstrated amplification of the 12q13-15 region in well-differentiated liposarcomas, making it useful for the diagnosis of these neoplasms.
  • [MeSH-major] Chromosomes, Human, Pair 12 / genetics. DNA, Complementary. Liposarcoma / diagnosis. Liposarcoma / genetics. Transcription Factor CHOP / genetics

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  • (PMID = 18517278.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DDIT3 protein, human; 0 / DNA, Complementary; 0 / Reagent Kits, Diagnostic; 147336-12-7 / Transcription Factor CHOP
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37. Kocaoğlu B, Erol B, Yalçin S, Bozkurt S, Altun E: Pediatric diffuse lipoblastomatosis of the foot -- a case report and review of the literature. Eur J Pediatr Surg; 2006 Jun;16(3):217-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diffuse lipoblastomatosis is a rare lipomatous tumor of infancy that derives from fetal-embryonal fat.
  • In spite of its benign nature, the tumor may behave in a locally aggressive manner and invade the surrounding tissues.
  • A case of isolated diffuse lipoblastomatosis of a 5-year-old boy in the plantar aspect of his right foot that has not been documented in that area before is described.
  • The clinical and radiological presentation and histologic evaluation of diffuse lipoblastomatosis are discussed, in order to make a differential diagnosis between this rare tumor and other soft tissue tumors.
  • In addition, the treatment principles of the tumor are described.
  • [MeSH-major] Foot Diseases / diagnosis. Lipoma / diagnosis

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  • (PMID = 16909365.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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38. Maruyama K, Motoyama S, Okuyama M, Sasaki K, Sato Y, Hayashi K, Nanjo H, Ogawa J: Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus. Surg Today; 2007;37(2):173-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus.
  • We describe how we removed a giant pedunculated atypical lipomatous tumor, arising in the cervical to upper thoracic esophagus and occupying a region extending from the cervical to the middle thoracic esophagus, through a cervical esophagotomy without thoracotomy or laparotomy.
  • We suggest that if the base of the tumor is located in the cervical portion of the esophagus, and if the tumor is not aggressive, the cervical approach is best, irrespective of the size of the tumor.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagectomy / methods. Liposarcoma / surgery. Neck / surgery. Thoracotomy / methods

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  • [Cites] J Am Coll Surg. 2004 Feb;198(2):320-1 [14964253.001]
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  • (PMID = 17243042.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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39. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • Multinucleated floret cells present in prolapsed orbital fat likely represent a reactive phenomenon, as they are not present in normal orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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40. Calò PG, Farris S, Tatti A, Tuveri M, Catani G, Nicolosi A: Primary mesenteric liposarcoma. Report of a case. G Chir; 2007 Aug-Sep;28(8-9):318-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary mesenteric liposarcoma. Report of a case.
  • Primary mesenteric liposarcomas are very rare neoplasms.
  • Surgical excision with a tumour-free margin was achieved.
  • The histologic appearances were those of a well-differentiated liposarcoma (atypical lipomatous tumour).
  • The patient is alive and disease-free 33 months after the surgery.
  • Primary mesenteric liposarcoma is often resectable and requires aggressive surgical management; in consideration of the high risk of tumour recurrence, the treatment of choice is a wide surgical excision.
  • [MeSH-minor] Adult. Female. Humans. Peritoneal Neoplasms / diagnosis

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  • (PMID = 17785044.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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41. Suster S, Morrison C: Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Histopathology; 2008 Feb;52(3):283-93
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  • [Title] Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue.
  • AIMS: To present eight cases of a distinctive morphological subtype of lipomatous tumour of soft tissue.
  • Four cases arose de novo and four cases presented as local recurrences of previously resected liposarcomas.
  • [MeSH-major] Liposarcoma / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. RNA-Binding Protein FUS / genetics. Soft Tissue Neoplasms / pathology. Transcription Factor CHOP / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Fatal Outcome. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Recurrence, Local. Sclerosis / pathology. Translocation, Genetic

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  • (PMID = 18269578.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Protein FUS; 0 / TLS-CHOP fusion protein, human; 147336-12-7 / Transcription Factor CHOP; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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42. Acar GO, Cansiz H, Acioğlu E, Yağiz C, Dervişoğlu S: Atypical lipomatous tumour of the head and neck region with dyspnea and dysphagia: a case report. Eur Arch Otorhinolaryngol; 2007 Aug;264(8):947-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumour of the head and neck region with dyspnea and dysphagia: a case report.
  • Liposarcoma is one of the most common soft tissue sarcomas in adults.
  • Atypical lipomatous tumour (ALT) rarely occurs in the head and neck region.
  • Histopathologic grade of these tumours affect prognosis of this disease.
  • In this article, a case of a huge ALT arising from the head and neck region and invading nearly entire left hemi-facial region is presented.
  • Clinical and histopathologic features and therapeutic approaches related to this tumour are discussed reviewing the literature.
  • [MeSH-major] Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / complications. Liposarcoma / complications
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 17361411.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. Siddiqui MK, Jyoti, Singh S, Mehrotra PK, Singh K, Sarangi R: Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study. Environ Int; 2006 Jul;32(5):630-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study.
  • Fifty women residing in and around New Delhi, India and identified to have benign (25 nos.) and malignant (25 nos.) breast lesions were studied for the first time to access the association between environmental exposure to lead and risk of breast cancer and to determine the potential of changes in trace elements concentration as a diagnostic marker and/or its etiological involvement in the disease.
  • Blood, tumor tissue and breast adipose tissue from tumor free area from each patient of the two groups, collected at the time of lumpectomy or mastectomy (only blood sample was collected from disease free control group), were analyzed to determine the concentration of Pb, Zn, Cu, Fe and Ca using Atomic Absorption Spectrometry.
  • Lead level was also higher in tumor tissue when compared with their respective normal tumor free breast tissue, though non-significant, in both benign and malignant cases.
  • Furthermore, these metals were also higher in tumor of malignant and benign cases as compared to normal tumor free breast tissue, many of them statistically significant (p<0.05/0.01/0.001).
  • However, Cu level was insignificantly lower in the blood and tumor tissue of malignant cases when compared with their benign counterparts while it was significantly higher (p<0.05) in tumor of benign cases when compared with those of their respective normal tumor free breast tissue.
  • There were statistically significant correlations between lead and trace element levels only in normal tumor free breast tissue of benign and malignant cases (r=0.41-0.73; p<0.05-0.001) but neither in blood nor tumor tissue of the two groups.
  • Further, modulation of trace elements level in both benign and malignant breast diseases patients may be of potential to be used as diagnostic marker of the disease process and its possible relationship etiologically.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Mammary Glands, Human / metabolism. Trace Elements / blood

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  • (PMID = 16580070.001).
  • [ISSN] 0160-4120
  • [Journal-full-title] Environment international
  • [ISO-abbreviation] Environ Int
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Trace Elements
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44. Zemel MB, Sun X: Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr; 2008 Jun;138(6):1047-52
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  • Accordingly, this study was designed to study the effects of the short-term (3 wk) basal suboptimal Ca (0.4%), high-Ca (1.2% from CaCO(3)), and high-dairy (1.2% Ca from milk) obesigenic diets on oxidative and inflammatory stress in adipocyte fatty acid-binding protein-agouti transgenic mice.
  • Adipose tissue reactive oxygen species (ROS) production and NADPH oxidase mRNA and plasma malondialdehyde (MDA) were reduced by the high-Ca diet (P < 0.001) compared with the basal diet and ROS and MDA were further decreased by the high-dairy diet (P < 0.001).
  • The high-Ca and -dairy diets also resulted in suppression of adipose tissue tumor necrosis factor alpha and interleukin (IL)-6 mRNA (P = 0.001) compared with the basal diet, whereas an inverse pattern was noted for adiponectin and IL-15 mRNA (P = 0.002).
  • These data demonstrate that dietary Ca suppresses adipose tissue oxidative and inflammatory stress.

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  • (PMID = 18492832.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Calcium, Dietary; 0 / Dietary Carbohydrates; 0 / Dietary Fats; 9007-41-4 / C-Reactive Protein
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45. Doğan R, Kara M, Yazicioğlu A, Onder S: Giant atypical lipomatous tumor of the mediastinum. Tuberk Toraks; 2008;56(1):100-3

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  • [Title] Giant atypical lipomatous tumor of the mediastinum.
  • Atypical lipomatous tumors, so-called well differentiated liposarcomas are the intermediate or locally aggressive form of adipocytic tumors.
  • Mediastinum is an uncommon localization for these tumors and they have a potential risk of recurrence following excision.
  • We herein report a case with a giant atypical lipomatous tumor located at the mediastinum that was surgically excised.
  • [MeSH-major] Liposarcoma / surgery. Mediastinal Neoplasms / surgery

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  • (PMID = 18330763.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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46. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600

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  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.
  • With the aim of both diagnosis and treatment, the lipomatous mass was removed by local resection.
  • In addition to the patient's age, histologic and cytogenetic analyses assisted the diagnosis of diffuse lipoblastoma.
  • [MeSH-major] Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Vecchio G, Amico P, Caltabiano R, Colella G, Lanzafame S, Magro G: Spindle cell/pleomorphic lipoma of the oral cavity. J Craniofac Surg; 2009 Nov;20(6):1992-4
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  • We herein report a rare case of a lipomatous tumor of the buccal mucosa, showing intermediate morphological features between spindle cell and pleomorphic lipomas, for which the term spindle cell/pleomorphic lipoma is proposed.
  • Morphological features helpful in the distinction between these tumors are emphasized.
  • [MeSH-major] Lipoma / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Liposarcoma / pathology. Male. Middle Aged. Mouth Mucosa / pathology. Receptors, Androgen / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis

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  • (PMID = 19881383.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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48. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Therefore, an accurate preoperative diagnosis is very important for proper treatment.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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49. Khan N, Afroz N, Fatima U, Raza MH, Rab AZ: Giant primary mesenteric liposarcoma: a rare case report. Indian J Pathol Microbiol; 2007 Oct;50(4):787-9
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  • Primary mesenteric liposarcoma is a rare malignant tumor of mesenchymal origin.
  • These tumors are often found to be of substantial size upon first clinical presentation.
  • We report a case of primary mesenteric liposarcoma in a 55 year old man who underwent laparotomy for the clinical/radiological impression of a mesenteric cyst.
  • Histopathology showed features of atypical lipomatous tumor / well differentiated liposarcoma (ALT/WDLS) with mixed histological pattern (e.g. lipoma like, sclerosing and myxoid areas) varying from area to area.
  • [MeSH-major] Liposarcoma / diagnosis. Liposarcoma / pathology. Mesentery / pathology

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  • (PMID = 18306555.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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50. Jung SM, Chang PY, Luo CC, Huang CS, Lai JY, Hsueh C: Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan. Pediatr Surg Int; 2005 Oct;21(10):809-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma/lipoblastomatosis is an uncommon benign lipomatous tumor affecting mainly infants and children.
  • Histologically, the majority (11/16) of primary tumors were of diffuse type.
  • Four patients experienced a recurrence of tumors in the neck (n = 2) and lower extremities (n = 2) 11-84 months after operation.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • [Cites] Genes Chromosomes Cancer. 1993 Jan;6(1):24-9 [7680218.001]
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  • (PMID = 16180007.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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51. Mentzel T, Palmedo G, Kuhnen C: Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. Mod Pathol; 2010 May;23(5):729-36
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  • [Title] Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases.
  • Well-differentiated spindle cell liposarcoma represents a rare atypical/low-grade malignant lipogenic neoplasm that has been regarded as a variant of atypical lipomatous tumor.
  • However, well-differentiated spindle cell liposarcoma tends to occur in subcutaneous tissue of the extremities, the trunk, and the head and neck region, contains slightly atypical spindled tumor cells often staining positively for CD34, and lacks an amplification of MDM2 and/or CDK4 in most of the cases analyzed.
  • The neoplasms arose on the shoulder, the chest wall, the thigh, the lower leg, the back of the hand, and in paratesticular location.
  • The size of the neoplasms ranged from 1.5 to 10 cm (mean: 6.0 cm).
  • All neoplasms were completely excised.
  • The neoplasms were confined to the subcutis in three cases, and in three cases, an infiltration of skeletal muscle was seen.
  • Histologically, the variably cellular neoplasms were composed of atypical lipogenic cells showing variations in size and shape, and spindled tumor cells with slightly enlarged, often hyperchromatic nuclei.
  • Multivacuolated lipoblasts were present in three neoplasms.
  • Immunohistochemically, CD34 was at least focally positive in all cases, whereas scattered tumor cells only showed a nuclear expression of MDM2 in two neoplasms.
  • Although well-differentiated spindle cell liposarcoma and atypical lipomatous tumor behave clinically similar, it can be speculated on the basis of clinicopathologic and molecular findings that well-differentiated spindle cell liposarcoma may constitute an independent entity rather than a morphologic variant of atypical lipomatous tumor, and may represent the atypical/low-grade counterpart of spindle cell lipoma.
  • [MeSH-major] Hand / pathology. Leg / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20228779.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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52. Kaneko G, Nishimoto K, Ogata K, Uchida A: [A case of lipomatous tumor arising from the paratesticular lesion]. Hinyokika Kiyo; 2009 Nov;55(11):725-7

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  • [Title] [A case of lipomatous tumor arising from the paratesticular lesion].
  • We encountered a case of lipomatous tumor in the left scrotum, which was clinically and radiologically quite similar to an inguinal hernia.
  • A 75-year-old male patient visited a nearby hospital complaining of a painless left scrotal swelling.
  • The tumor marker levels were within the normal range.
  • A preoperative diagnosis of inguinal hernia containing the omentum was made.
  • Microscopically, most of the tumor consisted of mature adipocytes, some of which had different cellular sizes.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Lipoma / pathology. Scrotum

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  • (PMID = 19946194.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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53. Gurel D, Kargi A, Lebe B: Pedunculated cutaneous spindle cell/pleomorphic lipoma. J Cutan Pathol; 2010 Sep;37(9):e57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell/pleomorphic lipoma is an infrequently seen benign adipose tissue tumor.
  • This tumor, mostly arising from the subcutaneous tissue, usually affects male patients and occurs in back, shoulders, head and neck area.
  • [MeSH-major] Lipoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Dermis / pathology. Humans. Male. Vimentin / metabolism

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  • (PMID = 19678825.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Vimentin
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54. Rau T, Soeder S, Olk A, Aigner T: Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma. Ann Diagn Pathol; 2006 Oct;10(5):279-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma.
  • Lipomas are very common benign soft tissue neoplasms.
  • Mature cartilage and bone arising in a lipoma is a rare event and is mostly associated with a parosteal localization of the neoplasm.
  • We describe a new case of osteochondrolipoma showing not only major adipocytic differentiation but also areas of fibrocytic and cartilaginous cell differentiation and bone formation (both endochondral and membranous).
  • The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells.
  • Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue.
  • [MeSH-major] Bone and Bones / pathology. Cartilage / pathology. Lipoma / pathology. Periosteum / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Aged. Cell Differentiation. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Humans. Male. Mesenchymal Stromal Cells / pathology. Ossification, Heterotopic / pathology. Thigh

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  • (PMID = 16979520.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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55. Sulentić P, Abdović S, Filipović J, Tomas D: Pedunculated myolipoma incidentally found in hernial sac: a case report. Acta Clin Croat; 2009 Jun;48(2):171-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of a very rare adipocytic tumor found during corrective surgery for incisional abdominal hernia is presented.
  • During surgery of incisional hernia, a part of small intestine along with a pedunculated tumor was found in hernial sac.
  • The tumor was attached to the medial intra-abdominal peritoneum.
  • On examination, the tumor presented as a totally encapsulated dimorphic benign neoplasm composed of mature adipocytes and well-differentiated smooth muscle cells.
  • Lipoblasts, floret-like giant cells, nuclear atypia, mitosis or proliferation of medium-sized arteries with thick muscular walls were not observed.
  • Tumor cells were negative for HMB45, estrogen and progesterone.
  • The diagnosis of myolipoma was established.
  • This tumor commonly presents as a large quiescent mass in retroperitoneum in adult females and to our knowledge this is the first report of myolipoma in hernial sac.
  • Characteristic findings, differential diagnosis, prognosis and the possible origin of such a neoplasm are discussed.
  • [MeSH-major] Hernia, Abdominal / surgery. Lipoma / diagnosis. Peritoneal Neoplasms / diagnosis

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  • (PMID = 19928417.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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56. Coffin CM, Lowichik A, Putnam A: Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol; 2009 Nov;33(11):1705-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma (LPB) is a benign neoplasm that occurs predominantly in early childhood.
  • Immunohistochemistry for S100 protein, CD34, and Mib-1 was performed on formalin-fixed, paraffin-embedded tissue using standard techniques.
  • Age at diagnosis ranged from 3 months to 16 years with 22% in the first year, 68% at 1 to 9 years, and 10% at 10 to 16 years.
  • Tumor diameter ranged from 1.2 to 15.5 cm.
  • Histologically, nodules of adipose and myxoid tissue were demarcated by bands of fibrous tissue.
  • The cells displayed a range of differentiation from multivacuolated lipoblasts to mature adipocytes.
  • In summary, this large series of LPB demonstrates its occurrence in older children and adolescents, documents a recurrence rate of 46% and confirms that the degree of adipocytic differentiation does not predict biologic behavior.
  • An unexpected finding was the presence in 17% of patients of central nervous system disorders such as seizures, autism, and developmental delay, congenital anomalies, Sturge-Weber syndrome, or a family history of lipomas.
  • These observations raise the question of whether predisposing genetic or other constitutional factors contribute to the development of LPB or whether LPB is indicative of a syndrome.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adolescent. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Child. Child, Preschool. Chromosome Aberrations. Chromosomes, Human, Pair 8. Female. Humans. Immunohistochemistry. Infant. Male. Neoplasm Recurrence, Local. S100 Proteins / analysis

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  • (PMID = 19738456.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / S100 Proteins
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57. Aust MC, Spies M, Kall S, Jokuszies A, Gohritz A, Vogt P: Posttraumatic lipoma: fact or fiction? Skinmed; 2007 Nov-Dec;6(6):266-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas are usually benign adipose tumors with as-yet unexplained pathogenesis and etiology.
  • A link between soft tissue trauma and the formation of lipomas has been described, with the latter being named posttraumatic lipomas.
  • The average time between soft tissue trauma and lipoma formation was 2.6 years (range, 0.5-6.0 years).
  • All tumors were located epifascially.
  • Pathology demonstrated capsulated and noncapsulated benign adipose tumors in 23 cases.
  • CONCLUSIONS: The pathogenetic link between soft tissue trauma and the formation of posttraumatic lipomas is still controversially discussed.
  • There are 2 potential explanations to correlate soft tissue trauma and adipose tissue tumor growth.
  • The first is the formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact.
  • A second possibility points toward lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation.
  • [MeSH-major] Adipose Tissue / injuries. Lipoma / etiology. Neoplasms, Adipose Tissue / etiology. Wounds, Nonpenetrating / complications

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  • (PMID = 17975353.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Kuriu A, Shimono T, Kuwabara M, Ashikaga R, Hosono M, Murakami T: Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult. Jpn J Radiol; 2010 Feb;28(2):166-8
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  • [Title] Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult.
  • We report a case of fourth ventricular mixed germ cell tumor (GCT) in a 20-year-old man.
  • Neuroradiological investigations revealed a fourth ventricular hemorrhagic tumor with adipose tissue.
  • We suspected mixed GCT because adipose tissue was seen preoperatively, but mixed GCT occurring after childhood in this location has not previously been reported.
  • We describe herein the imaging findings for mixed GCT and discuss the differential diagnoses of fourth ventricular tumors with adipose tissue.
  • [MeSH-major] Adipose Tissue / pathology. Adipose Tissue / radiography. Brain Neoplasms / diagnosis. Fourth Ventricle / pathology. Fourth Ventricle / radiography. Neoplasms, Germ Cell and Embryonal / diagnosis
  • [MeSH-minor] Adult. Biomarkers / blood. Biomarkers, Tumor / blood. Cerebral Ventriculography / methods. Chorionic Gonadotropin / blood. Contrast Media. Diagnosis, Differential. Follow-Up Studies. Headache / etiology. Humans. Hydrocephalus / complications. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods. Vomiting / etiology. Young Adult. alpha-Fetoproteins

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  • (PMID = 20182853.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin; 0 / Contrast Media; 0 / alpha-Fetoproteins
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59. Colella G, Biondi P, Caltabiano R, Vecchio GM, Amico P, Magro G: Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J; 2009;2:7906

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 75-year-old Italian male presented at our department with a large tumor at the tip of the tongue that had been present for over 30 years.
  • Histological examination showed an unencapsulated lipomatous tumor composed of mature adipocytes, uniform in size and shape, diffusely infiltrating striated muscle fibers of the tongue.

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  • (PMID = 19830025.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3302006
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60. Erickson-Johnson MR, Seys AR, Roth CW, King AA, Hulshizer RL, Wang X, Asmann YW, Lloyd RV, Jacob EK, Oliveira AM: Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. Mod Pathol; 2009 Dec;22(12):1541-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The discrimination between well-differentiated liposarcomas/atypical lipomatous tumors and lipomas can be diagnostically challenging at the histological level.
  • However, cytogenetic identification of ring and giant rod chromosomes supports the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumor.
  • MDM2 is consistently amplified in well-differentiated liposarcomas/atypical lipomatous tumors, and up to 25% in other sarcomas.
  • As part of a large genomic study of lipomatous neoplasms, we initially found CPM to be consistently amplified in well-differentiated liposarcomas/atypical lipomatous tumors.
  • To further explore this initial finding, we investigated the copy number status of MDM2 and CPM by fluorescent in situ hybridization (FISH) on a series of 138 tumors and 17 normal tissues, including 32 well-differentiated liposarcoma/atypical lipomatous tumors, 63 lipomas, 11 pleomorphic lipomas, 2 lipoblastomas, 30 other tumors and 17 normal fat samples.
  • All 32 well-differentiated liposarcoma/atypical lipomatous tumors showed amplification of MDM2 and CPM, usually >20 copies per cell.
  • The other tumors lacked MDM2 and/or CPM amplification.
  • Chromogenic in situ hybridization confirmed the above results on a subset of these tumors (n=27).
  • These findings suggest that identification of CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cell Differentiation. Gene Amplification. Lipoma / diagnosis. Liposarcoma / diagnosis. Metalloendopeptidases / genetics
  • [MeSH-minor] Comparative Genomic Hybridization. Diagnosis, Differential. GPI-Linked Proteins. Gene Dosage. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Genetic Testing. Humans. In Situ Hybridization, Fluorescence. Predictive Value of Tests. Proto-Oncogene Proteins c-mdm2 / genetics

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  • (PMID = 19820690.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPI-Linked Proteins; EC 3.4.17.12 / carboxypeptidase M; EC 3.4.24.- / Metalloendopeptidases; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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61. Weaver J, Goldblum JR, Turner S, Tubbs RR, Wang WL, Lazar AJ, Rubin BP: Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma. Mod Pathol; 2009 Jan;22(1):66-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Inflammatory liposarcoma is a variant of well-differentiated liposarcoma/atypical lipomatous tumor that consists of a mixture of lymphocytes, histiocytes, scattered atypical stromal cells, mature adipocytes, and rarely lipoblasts.
  • When the inflammatory infiltrate predominates, the morphological features overlap with various fibroinflammatory disorders including sclerosing mesenteritis and retroperitoneal fibrosis, making the diagnosis difficult.
  • Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma have characteristic molecular markers in the form of giant marker and ring chromosomes consisting of amplicons of 12q13-15, which includes MDM2.
  • [MeSH-major] Biomarkers, Tumor / genetics. Liposarcoma / diagnosis. Panniculitis, Peritoneal / diagnosis. Proto-Oncogene Proteins c-mdm2 / genetics. Retroperitoneal Fibrosis / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Gene Amplification. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Inflammation / diagnosis. Inflammation / genetics. Sensitivity and Specificity


62. Ferrari G, Paci M, Sgarbi G: Thymolipoma of the anterior mediastinum: videothoracoscopic removal using a bilateral approach. Thorac Cardiovasc Surg; 2006 Sep;54(6):435-7
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  • Thymolipoma, a rare benign neoplasm of the anterior mediastinum, is often asymptomatic and as a result it can become quite large before it is diagnosed.
  • CT is the most accurate diagnostic technique to identify the adipose tissue, but it often cannot make a differential diagnosis differentiating it from other anterior mediastinal masses; transthoracic biopsy also reveals the presence of fatty tissue, but a definitive diagnosis can only be achieved by means of surgical excision, which is also curative.
  • We describe the case of a young woman who presented with a fatty neoplasm of the anterior mediastinum.
  • The histopathological diagnosis was thymolipoma.
  • [MeSH-major] Lipoma / surgery. Mediastinal Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thymus Neoplasms / surgery

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  • (PMID = 16967386.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Skipworth RJ, Smith GH, Stewart KJ, Anderson DN: The tip of the iceberg: a giant pelvic atypical lipoma presenting as a sciatic hernia. World J Surg Oncol; 2006;4:33

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  • It illustrates the need to be aware that hernias may not always simply contain intra-abdominal viscera.
  • CASE PRESENTATION: A 36 year old woman presented with an expanding, yet reducible, right gluteal mass, indicative of a sciatic hernia.
  • However, magnetic resonance imaging demonstrated a large intra- and extra-pelvic fatty mass traversing the greater sciatic foramen.
  • The tumour was surgically removed through an abdomino-perineal approach.
  • Subsequent pathological examination revealed an atypical lipomatous tumour (synonym: lipoma-like well-differentiated liposarcoma).
  • CONCLUSION: The presence of a gluteal mass should always suggest the possibility of a sciatic hernia.
  • Although lipoma-like well-differentiated liposarcomas have only a low potential for recurrence, the variable nature of fatty tumours demands that patients require regular clinical and radiological review.

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  • (PMID = 16790047.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1526433
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64. Milczarek R, Klimek J: [Aromatase--key enzyme of estrogen biosynthesis]. Postepy Biochem; 2005;51(4):430-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It was pointed that unique human CYP19 gene expression results from presence of many tissue specific promoters and alternative splicing.
  • The molecular mechanism of control aromatase cytochrome P450 gene expression in various species ovaries, testes and human adipose tissue and placenta was discussed in details.
  • Because of a very important role of estrogen in breast cancer a molecular base of aberrant expression CYP19 gene in breast tumor and adipose tissue proximal to breast tumor and potential possibility of pharmacological silencing of this gene expression was discussed in the article.
  • [MeSH-minor] Adipose Tissue / metabolism. Animals. Antineoplastic Agents / pharmacology. Bone Development / physiology. Breast Neoplasms / drug therapy. Breast Neoplasms / genetics. Breast Neoplasms / metabolism. Female. Fertility / physiology. Gene Expression / drug effects. Humans. Male. Placenta / metabolism. Reproduction / physiology

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  • (PMID = 16676578.001).
  • [ISSN] 0032-5422
  • [Journal-full-title] Postepy biochemii
  • [ISO-abbreviation] Postepy Biochem.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Estrogens; EC 1.14.14.1 / Aromatase
  • [Number-of-references] 66
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65. Titiz A, Yilmaz YF, Ceyhan S, Unal T: Atypical lipomatous tumor in the submental region. J Craniofac Surg; 2008 Nov;19(6):1558-60
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  • [Title] Atypical lipomatous tumor in the submental region.
  • A 54-year-old male patient presented to our outpatient clinic complaining of a mass under his chin, which appeared nearly 1 year earlier.
  • Pathologic diagnosis was atypical lipomatous tumor.
  • Atypical lipomatous tumors/well-differentiated liposarcomas are rarely reported in the head and neck.
  • We review the clinical and management features of atypical lipomatous tumors.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Liposarcoma / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Cell Nucleus / ultrastructure. Contrast Media. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-mdm2 / analysis. S100 Proteins / analysis. Stromal Cells / pathology. Tomography, X-Ray Computed

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  • (PMID = 19098551.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Contrast Media; 0 / S100 Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 13
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66. Saifzadeh S, Derakhshanfar A, Hadian M: Congenital lipoblastoma in a neonate calf: first report in veterinary literature. Vet Dermatol; 2007 Apr;18(2):130-3
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  • Lipoblastoma is a rare benign tumour of adipose tissue that usually occurs in young children.
  • This case report describes the clinical and histopathological findings of a congenital lipoblastoma located at the tail base of a 2-day-old male calf.
  • Lipoblastoma should thus be considered in the differential diagnosis list for congenital adipose tissue tumours in animals.
  • [MeSH-major] Cattle Diseases / diagnosis. Lipoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Animals, Newborn. Cattle. Diagnosis, Differential. Male. Tail

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  • (PMID = 17355429.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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67. Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM: Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol; 2009 Dec;62(12):1127-35
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  • [Title] Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours.
  • METHODS: IHC for MDM2/CDK4 was carried out on a series of 129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours.
  • The cases were divided into four groups: WDLPS (n = 19), DDLPS (n = 10), benign adipocytic tumours (BAT) (n = 17), and other mesenquimal tumours (OMT) (n = 83).
  • IHC results were compared in each group and the diagnostic efficacy of the test in identifying WDLPS and DDLPS among the other soft tissue tumours was determined.
  • A percentage of tumour cell positivity was evaluated to better characterise the pattern of tumour immunostaining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase 4 / metabolism. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Sensitivity and Specificity

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  • (PMID = 19946100.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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68. Nahal A, Meterissian S: Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma. Am J Clin Oncol; 2009 Aug;32(4):353-5
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  • OBJECTIVES: Soft tissue tumors with dual adipocytic and smooth muscle differentiation are generally rare with most being benign.
  • Sarcomas with dual fatty and smooth muscle differentiation are even rarer.
  • The purpose of this paper is to discuss a rare presentation of a lipoleiomyosarcoma and review, the method of pathologic diagnosis and the literature.
  • METHODS: Detailed clinical and histopathologic review of a clinical case and review of the literature using PUBMED for publications on lipoleiomyosarcoma.
  • Pathologic diagnosis requires immunohistochemical staining with MDM2 and CDK4.
  • Its diagnosis requires immunohistochemistry and awareness of its possible existence.
  • [MeSH-major] Leiomyosarcoma / pathology. Liposarcoma / pathology. Neoplasm Invasiveness / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Colectomy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Middle Aged. Neoplasm Staging. Pelvic Pain / diagnosis. Pelvic Pain / etiology. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19363435.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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69. Zhang H, Erickson-Johnson M, Wang X, Oliveira JL, Nascimento AG, Sim FH, Wenger DE, Zamolyi RQ, Pannain VL, Oliveira AM: Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors. Am J Surg Pathol; 2010 Sep;34(9):1304-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors.
  • Ancillary molecular testing has been advocated for diagnostic accuracy in the differentiation of lipomas from atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDL); however, the implications and specific indications for use are not well-established in the current literature.
  • Herein, we extend previous findings by quantitatively evaluating the impact of molecular testing of lipomatous neoplasms in our routine clinical practice, how it modifies the historical perspective of their clinical course, and the effect of distinct surgical procedures in modulating the risk of local recurrence for these tumors after molecular classification.
  • On the basis of these analyses, we suggest a specific set of basic recommendations for complementary molecular assessment in the diagnosis of lipomatous tumors.
  • Four hundred and five lipomatous neoplasms located in the trunk and extremities were analyzed histologically and for the presence of 12q13-15 amplification on paraffin-embedded tissues by assessing MDM2/CPM amplification.
  • The 405 tumors were histologically classified as ordinary lipoma (n=324), intramuscular lipoma (n=29), and ALT/WDL (n=52).
  • The level of agreement between the histologic diagnosis and the molecular diagnosis was high (96%) but pathologists showed a tendency to overestimate cytologic atypia and the diagnosis of ALT/WDL (precision, 79%; accuracy, 88%).
  • Molecular assessment led to a major diagnostic reclassification in 18 tumors (4%).
  • Eleven of the tumors histologically classified as ALT/WDL were reclassified as ordinary lipoma (n=5) and intramuscular lipoma (n=6); none of which recurred.
  • Multivariate analyses after molecular assessment showed tumor type and type of resection to be associated with the risk of local recurrence.
  • Complementary molecular testing refines the histologic classification of lipomatous tumors and better estimates the impact of surgical procedures on the risk of local recurrence.
  • Pathologists tend to overestimate the degree of cytologic atypia and the indiscriminate use of molecular testing should be avoided, especially for extremity-based tumors.
  • Molecular testing should be considered for "relapsing lipomas," tumors with questionable cytologic atypia (even if widely excised), or for large lipomatous tumors (>15 cm) without diagnostic cytologic atypia.
  • [MeSH-major] Lipoma / genetics. Liposarcoma / genetics. Molecular Diagnostic Techniques. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Chromosomes, Human, Pair 12. DNA, Neoplasm / analysis. Disease-Free Survival. Extremities. Female. GPI-Linked Proteins. Gene Amplification. Humans. In Situ Hybridization, Fluorescence. Male. Metalloendopeptidases / genetics. Metalloendopeptidases / metabolism. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism. Treatment Outcome

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  • (PMID = 20679883.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / GPI-Linked Proteins; EC 3.4.17.12 / carboxypeptidase M; EC 3.4.24.- / Metalloendopeptidases; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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70. Allon I, Vered M, Dayan D: Liposarcoma of the tongue: clinico-pathologic correlations of a possible underdiagnosed entity. Oral Oncol; 2005 Aug;41(7):657-65
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  • [Title] Liposarcoma of the tongue: clinico-pathologic correlations of a possible underdiagnosed entity.
  • Liposarcoma (LS), one of the most common malignant tumors, is considered as a rarity in the oral cavity, the tongue being the most frequent site for its occurrence.
  • LS of the tongue is a tumor of adult and old age, with a mean age of approximately 62 years and a peak incidence in the seventh and eighth decades.
  • Clinically, it is a long-standing tumor that commonly presents as a solitary nodular mass, but can also present as a multi-nodular lesion.
  • The most common histopathologic type is that of atypical lipomatous tumor (ALT)/well-differentiated LS (75%).
  • LS can be easily misdiagnosed with both benign and malignant lipomatous and non-lipomatous tumors.
  • When a lipomatous lesion is encountered in the oral cavity, and especially in the tongue, LS should certainly be among the lesions that top the list of differential diagnosis.
  • The follow-up must be on a long-term basis since this tumor can recur years after initial surgical treatment and can also undergo dedifferentiation.
  • [MeSH-major] Liposarcoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16023982.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 27
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71. Singh NG, Kahvic M, Rifaat AA, Alenezi I: Foreign body reaction to soft tissue filler simulating atypical lipomatous tumor: report of a case. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):778-80
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  • [Title] Foreign body reaction to soft tissue filler simulating atypical lipomatous tumor: report of a case.
  • Injectable silicone or microimplant has been extensively used for the soft tissue augmentation.
  • Here we report a case of cystic granulomatous reaction to injectable tissue filler, possibly liquid silicone, used for tissue augmentation in the buttocks.
  • These morphologic features were highly reminiscent of atypical lipomatous tumor.
  • [MeSH-major] Buttocks / pathology. Foreign-Body Reaction / diagnosis. Foreign-Body Reaction / pathology. Prostheses and Implants / adverse effects. Skin Diseases / diagnosis. Skin Diseases / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans. Lipoma / pathology. Microscopy

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  • (PMID = 21045415.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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72. Femia A, Klein PA: Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist. Dermatol Online J; 2010;16(4):15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipomas are common benign neoplasms of adipose tissue.
  • [MeSH-major] Diabetes Mellitus, Type 2 / drug therapy. Hypoglycemic Agents / adverse effects. Lipoma / chemically induced. Neoplasms, Multiple Primary / chemically induced. PPAR gamma / agonists. Skin Neoplasms / chemically induced. Thiazolidinediones / adverse effects
  • [MeSH-minor] Adipose Tissue / drug effects. Aged. Female. Humans. Iatrogenic Disease

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  • (PMID = 20409422.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoglycemic Agents; 0 / PPAR gamma; 0 / Thiazolidinediones; X4OV71U42S / pioglitazone
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73. Evans HL: Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol; 2007 Jan;31(1):1-14
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  • [Title] Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years.
  • Sixty-one cases of neoplasms composed wholly or in part of atypical lipomatous tumor were reviewed.
  • The cases were divided into 4 groups based on the findings in the initial excision specimen: conventional atypical lipomatous tumor (n=15), cellular atypical lipomatous tumor (n=21), dedifferentiated liposarcoma (n=24), and atypical lipomatous tumor with a pleomorphic liposarcoma-like component (n=1).
  • The term "cellular atypical lipomatous tumor" was applied to atypical lipomatous tumors having areas of increased cellularity that when non-lipogenic lacked the 5 mitotic figures per 10 high-power fields (maximal rate) required for a dedifferentiated component and when lipogenic fell short of being truly pleomorphic liposarcoma-like.
  • The most important prognostic factor was tumor location, as none of the 12 patients with a subcutaneous or intramuscular neoplasm died of tumor.
  • Among the 49 patients with neoplasms of central body sites (mostly retroperitoneum), those with dedifferentiated liposarcoma had significantly shorter survival (median 77 mo) than those with cellular (median 142 mo) or conventional (median 209 mo) atypical lipomatous tumor, whereas there was no statistically significant difference between the latter 2 categories.
  • Patients with atypical lipomatous tumor (either cellular or conventional) in central body sites had significantly shorter survival if the tumor transformed into dedifferentiated liposarcoma in recurrence, and, conversely, those with central body site dedifferentiated liposarcoma had significantly longer survival if it recurred as atypical lipomatous tumor.
  • [MeSH-major] Liposarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Follow-Up Studies. Humans. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • (PMID = 17197914.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. McQueen C, Montgomery E, Dufour B, Olney MS, Illei PB: Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol; 2010 Jan;17(1):38-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant hypopharyngeal atypical lipomatous tumor.
  • Microscopically, they display an admixture of fibrovascular and adipose tissue that is coated by unremarkable squamous mucosa.
  • Here, we report a case that had scattered hyperchromatic cells and lipoblasts within the adipose tissue component.
  • In other anatomic sites similar appearing lesions have been interpreted as pedunculated liposarcomas/atypical lipomatous tumors that are more prone to local recurrences than classic giant fibrovascular polyps.
  • To confirm our suspicion of liposarcomatous differentiation, we performed immunohistochemistry for MDM2 and p53, 2 markers that are known to be negative in benign lipomatous lesions and positive in well-differentiated liposarcomas/atypical lipomatous tumors.
  • The scattered atypical hyperchromatic cells and the lipoblasts both exhibited strong nuclear staining for both markers and supported the diagnosis of pedunculated giant hypopharyngeal atypical lipomatous tumor.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Liposarcoma / pathology
  • [MeSH-minor] Humans. Immunohistochemistry. Male. Middle Aged. Polyps / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20032637.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 51
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75. Aftab S, Casey A, Tirabosco R, Kabir SR, Saifuddin A: Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review. Skeletal Radiol; 2010 Oct;39(10):1039-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review.
  • Solitary fibrous tumour (SFT) is a rare soft tissue tumour of uncertain histogenesis and unpredictable biological behaviour, which was first described in the pleura and subsequently in many extra-pleural locations.
  • We present the clinical, radiological and histological features of a case of intraspinal fat-forming SFT, along with a literature review.
  • This is the first known report of a fat-forming SFT in the spine.
  • [MeSH-major] Solitary Fibrous Tumors / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hemangiopericytoma / diagnosis. Hemangiopericytoma / surgery. Humans. Lipoma / diagnosis. Lipoma / surgery. Magnetic Resonance Imaging / methods. Male. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20628877.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] Lipomatous hemangiopericytoma
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76. Patel J, Deb R, Speake W, Macculloch TA: Primary small bowel liposarcoma (atypical lipomatous tumour) with myogenic differentiation. Sarcoma; 2010;2010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary small bowel liposarcoma (atypical lipomatous tumour) with myogenic differentiation.
  • Primary small intestinal liposarcomas originating in the small bowel are uncommon with a generally poor prognosis due to the advanced stage at the time of diagnosis.
  • The current case is unusual as the tumour seemingly originated from the bowel and the well-differentiated component was seen extensively infiltrating the bowel wall including the small bowel submucosa.

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  • (PMID = 20706648.001).
  • [ISSN] 1369-1643
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2913843
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77. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Rajeswaran R, Murthy J, Chandrasekharan A, Joseph S: Case Report: Congenital infiltrating lipomatosis of face. Indian J Radiol Imaging; 2008 Nov;18(4):306-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Congenital infiltrating lipomatosis of the face is a rare condition characterized by diffuse fatty infiltration of the facial soft tissues.
  • It is a type of lipomatous tumor that is congenital in origin; it is rare and seen usually in childhood.

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  • (PMID = 19774187.001).
  • [ISSN] 0971-3026
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2747453
  • [Keywords] NOTNLM ; Congenital / lipomatosis
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79. Ruiz E, Pozo P, Toselli L, Fernández M, Christiansen S, Lambertini R: Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma. Urology; 2008 Jun;71(6):1067-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma.
  • Paratesticular tumors are extremely rare, with paratesticular rhabdomyosarcoma being the most common finding.
  • A 6-month-old boy presented with an asymptomatic, right intrascrotal mass whereby the testicle was surrounded by a friable lipomatous tumor.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Testicular Diseases / pathology. Testicular Neoplasms / pathology. Xanthogranuloma, Juvenile / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Male

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  • (PMID = 18538690.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Matushansky I, Hernando E, Socci ND, Matos T, Mills J, Edgar MA, Schwartz GK, Singer S, Cordon-Cardo C, Maki RG: A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas. Am J Pathol; 2008 Apr;172(4):1069-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.
  • We hypothesized that sarcomas of soft tissue could be categorized by their developmental/differentiation status from stem cell to mature tissue, similar to the hematological malignancies.
  • We conducted gene expression analyses during in vitro differentiation of human mesenchymal stem cells into adipose tissue, as a representative mature connective tissue, and identified genes whose expression changed significantly during adipogenesis.
  • Gene clustering and distance correlation analysis allowed the assignment of a unique time point during adipogenesis that strongly correlates to each of the four major liposarcoma subtypes.
  • Using a novel gene expression strategy, in which liposarcomas are compared to their corresponding adipocytic maturing cells, we identified a group of genes overexpressed in liposarcomas that indicate the stage of differentiation arrest, ie, sharing a similar expression profile to adipocytic cells at a corresponding stage of differentiation, and a distinct set of genes overexpressed in liposarcomas that are not found in the corresponding stage of differentiation.
  • Our results indicate that a degree of developmental maturity can be quantitatively assigned to solid tumors, supporting the notion that transformation of a solid tumor stem cell can occur at distinct stages of maturation.

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  • (PMID = 18310505.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / CA 47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2276417
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81. Laco J, Mentzel T, Hornychova H, Kohout A, Jirousek Z, Ryska A: Atypical lipomatous tumors of the tongue: report of six cases. Virchows Arch; 2009 Oct;455(4):383-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumors of the tongue: report of six cases.
  • We report six new cases of atypical lipomatous tumor (ALT) of the tongue, and detection of mdm-2 and CDK4 expression by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, was performed.
  • The tumors arose at the lateral side of the tongue, and in one case, multiple tumor nodules were noted.
  • Immunohistochemically, tumor cells revealed expression of vimentin (five of five), S100 (five of five), mdm-2 (three of five), and CDK4 (four of five).
  • Both these markers may be of help in the differential diagnosis of ALT versus lipoma.
  • Based on current data, the term ALT is strongly recommended for tumors occurring in the tongue to prevent inadequate treatment.
  • [MeSH-major] Lipoma / pathology. Liposarcoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 19816710.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; EC 2.3.2.27 / MDM2 protein, human; EC 2.3.2.27 / Proto-Oncogene Proteins c-mdm2; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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82. Fimmanò A, Coppola Bottazzi E, Cirillo C, Tammaro P, Casazza D: [Giant atypical muscle-involving lipoma of the right thigh: a case report and review of the literature]. Chir Ital; 2005 Nov-Dec;57(6):773-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrasonography confirmed the presence of the tumefaction but did not allow us to identify its origin with certainty.
  • The histological findings indicated an atypical lipomatous tumour.
  • [MeSH-major] Lipoma. Soft Tissue Neoplasms. Thigh

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  • (PMID = 16400775.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 14
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83. Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA: C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Genes Chromosomes Cancer; 2010 Sep;49(9):810-8
SciCrunch. HGNC: Data: Gene Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma.
  • Chondroid lipoma, a rare benign adipose tissue tumor, may histologically resemble myxoid liposarcoma or extraskeletal myxoid chondrosarcoma, but is genetically distinct.
  • In this study, an identical reciprocal translocation, t(11;16)(q13;p13), was identified in three chondroid lipomas, a finding consistent with previously isolated reports.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20607705.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA036727-24S59009; United States / NCI NIH HHS / CA / 5 P30 CA036727-2452; United States / NCI NIH HHS / CA / P30 CA036727-24S59009; United States / NCI NIH HHS / CA / U-10-CA98543-091
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MKL2 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Transcription Factors
  • [Other-IDs] NLM/ NIHMS203810; NLM/ PMC2904421
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84. Moritani N, Yamada T, Mizobuchi K, Wakimoto M, Ikeya Y, Matsumura T, Mishima K, Iida S: Atypical lipomatous tumor of the tongue: report of a case. Acta Med Okayama; 2010 Aug;64(4):257-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumor of the tongue: report of a case.
  • The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL).
  • This tumor occurs very rarely in the tongue.
  • Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites.
  • A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue.
  • Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless.
  • We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia.
  • Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia.
  • [MeSH-major] Liposarcoma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Lipoma / diagnosis. Lipoma / pathology. Male. Prognosis. Treatment Outcome

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  • (PMID = 20802543.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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85. López-Ferrer P, Jiménez-Heffernan JA, Yébenes L, Vicandi B, Viguer JM: Fine-needle aspiration cytology of lipoblastoma: a report of two cases. Diagn Cytopathol; 2005 Jan;32(1):32-4
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  • Lipoblastoma is an uncommon lipomatous tumor that typically occurs in infants and children.
  • Smears showed fragments of adipose tissue that consisted of numerous vacuolated adipocytes with few stroma.
  • Myxoid stromal material was a remarkable finding in one case.
  • Cytologic features were characteristic enough to permit a specific diagnosis (adipose tumor suggestive of lipoblastoma).
  • The differential diagnosis should consider lipoma with regressive changes, well-differentiated and mixoid liposarcoma.
  • In addition to cytologic features, the patient's age is very useful for differentiation.
  • [MeSH-major] Adipocytes / pathology. Biopsy, Fine-Needle / methods. Lipoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15584040.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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86. Tosios KI, Koutlas IG, Kyriakopoulos VF, Balta M, Theologie-Lygidakis N, Vardas E, Iatrou I: Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Oct;110(4):492-7
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  • [Title] Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes.
  • Angiomyolipoma (AML) is the most common benign mesenchymal neoplasm of the kidneys with well-established clinical and morphological features.
  • The oral and maxillofacial pathology literature contains several examples that identify angiomyomatous proliferations of the oral mucosa that contain an adipocytic component as analogous to classic renal AMLs although they differ significantly in their immunohistochemical phenotype.
  • Herein, through review of the pertinent oral pathology literature and the detailed description of 2 lesions, one an oral angiomyoma with an adipocytic component and the other an apparently hamartomatous angioleiomyomatous proliferation with adipocytes, we provide, in our opinion, a solid argument against the use of the term AML for non-PEComatous oral tumors.
  • [MeSH-major] Angiomyolipoma / classification. Mouth Neoplasms / classification. Terminology as Topic

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20674420.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / von Willebrand Factor
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87. Jin MS, Ha HJ, Baek HJ, Lee JC, Koh JS: Adenomyomatous hamartoma of lung mimicking benign mucinous tumor in fine needle aspiration biopsy: a case report. Acta Cytol; 2008 May-Jun;52(3):357-60
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  • [Title] Adenomyomatous hamartoma of lung mimicking benign mucinous tumor in fine needle aspiration biopsy: a case report.
  • BACKGROUND: Typical cytologic features of pulmonary hamartoma (PH) are usually smears of hyaline cartilage, fibrous tissue, smooth muscle, adipocytic components and respiratory epithelium.
  • Cytologic features of adenomyomatous hamartoma, a special variant of PH, are not documented in the literature and are confused with epithelial neoplasm in the case of sparse stromal cellularity.
  • The patient underwent surgery for the tumor, and it was histologically proven to be an adenomyomatous hamartoma.
  • This case demonstrates the wide spectrum of PH in FNAB and led us to consider PH as a differential diagnosis despite lack of chondromyxoid stromal components.
  • [MeSH-major] Biopsy, Fine-Needle. Hamartoma / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Humans. Male. Middle Aged. Thoracic Surgery, Video-Assisted. Treatment Outcome

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  • (PMID = 18540306.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Fernández-Sueiro JL, Pinto JA, Blanco FJ, Freire M, Veiga JA, Galdo F, González-Gay MA: Multiple parosteal lipoma associated to polyarthritis. Joint Bone Spine; 2006 Mar;73(2):202-4
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  • Parosteal lipoma is a benign adipose tissue tumor situated directly in the bone cortex.
  • We describe a patient who presented with polyarthritis associated with multiple parosteal lipomatous involvement.
  • A tissue sample from the distal portion of the forearm confirmed the presence of cumulative fat tissue with nodes of esteatonecrosis.
  • [MeSH-major] Arthritis / etiology. Bone Neoplasms / complications. Lipoma / complications. Periosteum / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Drug Therapy, Combination. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prednisone / therapeutic use. Tomography, X-Ray Computed. Wrist / pathology. Wrist / radiography

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  • (PMID = 16226479.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; VB0R961HZT / Prednisone
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89. Svegliati-Baroni G, Candelaresi C, Saccomanno S, Ferretti G, Bachetti T, Marzioni M, De Minicis S, Nobili L, Salzano R, Omenetti A, Pacetti D, Sigmund S, Benedetti A, Casini A: A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol; 2006 Sep;169(3):846-60
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  • [Title] A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.
  • Insulin resistance induces nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH).
  • We used a high-fat, high-calorie solid diet (HFD) to create a model of insulin resistance and NASH in nongenetically modified rats and to study the relationship between visceral adipose tissue and liver.
  • Obesity and insulin resistance occurred in HFD rats, accompanied by a progressive increase in visceral adipose tissue tumor necrosis factor (TNF)-alpha mRNA and in circulating free fatty acids.
  • HFD also decreased adiponectin mRNA and peroxisome proliferator-activated receptor (PPAR)-alpha expression in the visceral adipose tissue and the liver, respectively, and induced hepatic insulin resistance through TNF-alpha-mediated c-Jun N-terminal kinase (JNK)-dependent insulin receptor substrate-1Ser307 phosphorylation.
  • Supplementation of n-3 polyunsaturated fatty acid, a PPARalpha ligand, to HFD-treated animals restored hepatic adiponectin and PPARalpha expression, reduced TNF-alpha hepatic levels, and ameliorated fatty liver and the degree of liver injury.
  • Thus, our model mimics the most common features of NASH in humans and provides an ideal tool to study the role of individual pathogenetic events (as for PPARalpha down-regulation) and to define any future experimental therapy, such as n-3 polyunsaturated fatty acid, which ameliorated the degree of liver injury.
  • [MeSH-major] Fatty Acids, Omega-3 / metabolism. Fatty Liver / metabolism. Insulin Resistance. Intra-Abdominal Fat / metabolism. Liver / metabolism
  • [MeSH-minor] Animals. Apoptosis. Disease Models, Animal. Down-Regulation. Fibrosis / metabolism. Fibrosis / pathology. Food, Formulated / adverse effects. Hepatocytes / metabolism. Hepatocytes / pathology. Humans. Insulin Receptor Substrate Proteins. JNK Mitogen-Activated Protein Kinases / metabolism. Male. Necrosis / metabolism. Necrosis / pathology. Oxidative Stress. Phosphoproteins / metabolism. Protein Processing, Post-Translational. RNA, Messenger / biosynthesis. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / biosynthesis

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  • (PMID = 16936261.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids, Omega-3; 0 / IRS1 protein, human; 0 / Insulin Receptor Substrate Proteins; 0 / Irs1 protein, rat; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases
  • [Other-IDs] NLM/ PMC1698833
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90. Li X, Jin L, Cui Q, Wang GJ, Balian G: Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int; 2005 Jan;16(1):101-8
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  • These changes indicate enhanced adipogenesis and decreased osteogenesis by mesenchymal cells in vitro, together with a decrease in VEGF, a potent angiogeneic factor, suggesting that dexamethasone may shunt uncommitted osteoprogenitor cells in marrow from osteoblastic differentiation into the adipocytic pathway, leading to diminished vascularization and eventual osteonecrosis.
  • [MeSH-minor] Adipocytes / physiology. Animals. Cell Differentiation / physiology. Cell Line. Core Binding Factor Alpha 1 Subunit. Down-Regulation / genetics. Mice. Mice, Inbred BALB C. Neoplasm Proteins / genetics. Osteocalcin / genetics. Osteonecrosis / genetics. PPAR gamma / genetics. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction / methods. Transcription Factors / genetics. Vascular Endothelial Growth Factor A / genetics

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  • (PMID = 15205891.001).
  • [ISSN] 0937-941X
  • [Journal-full-title] Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
  • [ISO-abbreviation] Osteoporos Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 1 Subunit; 0 / Glucocorticoids; 0 / Neoplasm Proteins; 0 / PPAR gamma; 0 / RNA, Messenger; 0 / Transcription Factors; 0 / Vascular Endothelial Growth Factor A; 104982-03-8 / Osteocalcin; 7S5I7G3JQL / Dexamethasone
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91. Walter M, Liang S, Ghosh S, Hornsby PJ, Li R: Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene; 2009 Jul 30;28(30):2745-55
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  • [Title] Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells.
  • Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated.
  • Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model.
  • Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs.
  • Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells.

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  • [CommentIn] Oncogene. 2010 Apr 29;29(17):2599-600; author reply 2601-3 [20140019.001]
  • (PMID = 19483720.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA093506-08; United States / NCI NIH HHS / CA / R01 CA093506; United States / NCI NIH HHS / CA / R01 CA093506-05A1; United States / NCI NIH HHS / CA / CA093506-05A1; United States / NCI NIH HHS / CA / CA93506; United States / NCI NIH HHS / CA / CA093506-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cofilin 1; 0 / Interleukin-6; 0 / ROCK1 protein, human; EC 2.7.11.1 / rho-Associated Kinases
  • [Other-IDs] NLM/ NIHMS111638; NLM/ PMC2806057
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92. Tanas MR, Rubin BP, Tubbs RR, Billings SD, Downs-Kelly E, Goldblum JR: Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience. Arch Pathol Lab Med; 2010 Dec;134(12):1797-803
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  • [Title] Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience.
  • CONTEXT: Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH).
  • OBJECTIVE: To determine the utility of FISH in the diagnosis of mesenchymal neoplasms.
  • DESIGN: Two hundred thirty soft tissue cases analyzed by FISH were reviewed retrospectively.
  • RESULTS: Morphologic patterns where FISH was used included high-grade round cell sarcomas (n  =  67), nonmyogenic spindle cell sarcomas (n  =  40), low-grade myxoid neoplasms (n  =  34), adipocytic neoplasms (n  =  20), and melanocytic neoplasms (n  =  19).
  • Fifty cases did not fit into the previously mentioned categories.
  • SYT FISH (96% of monophasic synovial sarcomas were positive; 0% of malignant peripheral nerve sheath tumor were positive) and DDIT3 FISH (100% of myxoid/round cell liposarcomas; no other neoplasm positive) were very sensitive and specific.
  • EWSR1 FISH was very sensitive and specific in the differential diagnosis of melanocytic neoplasms (88% of clear cell sarcomas were positive; all melanomas were negative).
  • EWSR1 FISH was sensitive among high-grade round cell sarcomas (positive in 100% of desmoplastic small round cell tumors and 96% of Ewing sarcoma/primitive neuroectodermal tumors) but not specific because clear cell sarcoma, extraskeletal myxoid chondrosarcoma, and a subset of round cell liposarcomas also harbor rearrangements of EWSR1.
  • FUS FISH was very sensitive in detecting low-grade fibromyxoid sarcomas (91% positive) but not specific because most myxoid/round cell liposarcomas also contain rearrangements of FUS.
  • All atypical lipomatous tumors were positive for amplification of MDM2, whereas all lipomas were negative.
  • CONCLUSION: FISH is a useful adjunct in the diagnosis of mesenchymal neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Melanoma / diagnosis. Neoplasms, Adipose Tissue / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Chromosome Aberrations. Humans. Molecular Diagnostic Techniques

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  • (PMID = 21128778.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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93. Shi HY, Wei LX, Wang HT, Sun L: Clinicopathological features of atypical lipomatous tumors of the laryngopharynx. J Zhejiang Univ Sci B; 2010 Dec;11(12):918-22
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  • [Title] Clinicopathological features of atypical lipomatous tumors of the laryngopharynx.
  • Atypical lipomatous tumor (ALT) of the laryngopharynx is rare.
  • All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass.
  • Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5).
  • Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT.
  • Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4).
  • Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up.
  • ALT of laryngopharynx is an indolent tumor.
  • Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Lipoma / pathology

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  • (PMID = 21121069.001).
  • [ISSN] 1862-1783
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Other-IDs] NLM/ PMC2997399
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94. Jaovisidha S, Suvikapakornkul Y, Woratanarat P, Subhadrabandhu T, Nartthanarung A, Siriwongpairat P: MR imaging of fat-containing tumours: the distinction between lipoma and liposarcoma. Singapore Med J; 2010 May;51(5):418-23
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  • INTRODUCTION: This study aimed to retrospectively review the magnetic resonance (MR) imaging features of the lipomatous tumour in order to differentiate between lipoma and liposarcoma.
  • The images were assessed for the number, site, size and margin of the lesions, as well as the signal intensity (homogenous, bright signal on T1-weighted [T1W] image, bright signal suppressed on T1W with fat-suppression image, bright signal on T2-weighted with fat-suppression image), the internal architecture (thin/thick septum, cystic change), the effect on the surrounding tissue (oedema, neurovascular involvement) and the enhancement pattern.
  • RESULTS: A partially ill-defined margin, neurovascular involvement, enhancing thick/nodular septum and a partially bright signal intensity on T1W images were statistically significant MR imaging features that favoured a diagnosis of liposarcoma (p-value is less than 0.0001).
  • Male gender, an internal cystic change and surrounding soft tissue oedema increased the risk of liposarcoma approximately 2.8, 3.5 and 3.5 times, respectively, compared with the reference group (lipoma), but this was not a statistically significant finding.
  • CONCLUSION: Statistically significant MR imaging features that favour a diagnosis of liposarcoma included a partially ill-defined margin, neurovascular involvement, enhancing thick/nodular septum, and a partially bright signal intensity on T1W images.
  • [MeSH-major] Lipoma / diagnosis. Liposarcoma / diagnosis. Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Confidence Intervals. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Muscle Neoplasms / diagnosis. Muscle Neoplasms / pathology. Odds Ratio. Retrospective Studies. Risk Factors

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  • (PMID = 20593147.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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95. Olaleye O, Fu B, Moorthy R, Lawson C, Black M, Mitchell D: Left supraclavicular spindle cell lipoma. Int J Otolaryngol; 2010;2010:942152

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Background. Spindle cell lipoma (SCL) is a benign lipomatous tumour, typically occurring in the posterior neck, shoulder or upper back of elderly males.
  • This case highlights a rare presentation of SCL and the need for pre-operative diagnosis. Case Report.
  • CT neck showed a left supraclavicular mass of fatty density with fine internal septations.
  • A low-grade liposarcoma could not be excluded. Histopathology.
  • Conclusion. Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management.

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  • (PMID = 20508829.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2876251
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96. Miller DV, Tazelaar HD: Cardiovascular pseudoneoplasms. Arch Pathol Lab Med; 2010 Mar;134(3):362-8
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  • CONTEXT: Primary cardiac tumors are rare and the great majority are benign neoplasms.
  • Mass-forming reactive and pseudoneoplastic growths are less common, but recognizing and distinguishing these lesions from the neoplasms they resemble is critical to appropriate patient care.
  • OBJECTIVE: The general clinical, imaging, gross pathologic, and histologic features of 5 important pseudoneoplasms (inflammatory myofibroblastic tumor, hamartoma of mature cardiac myocytes, mesothelial/monocytic cardiac excrescences, calcified amorphous tumor, and lipomatous hypertrophy of the atrial septum) are discussed, with an emphasis on features differentiating them from other benign and malignant tumors.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Arch Pathol Lab Med. 2010 Nov;134(11):1584-6 [21043810.001]
  • (PMID = 20196664.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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97. Katenkamp K, Katenkamp D: Soft tissue tumors: new perspectives on classification and diagnosis. Dtsch Arztebl Int; 2009 Sep;106(39):632-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soft tissue tumors: new perspectives on classification and diagnosis.
  • BACKGROUND: In recent years, new tumor entities have been described and previously known tumor types have undergone a reassessment.
  • This article offers an overview of recent developments in the classification and interpretation of soft tissue tumors.
  • METHODS: Selective review of publications from 1990 until 2008 from the literature database of the Consultation and Referral Center for Soft Tissue Tumors in Jena.
  • The current status of the classification and morphological diagnosis of these tumors is described.
  • RESULTS: The description of the biological behavior of soft tissue tumors has become more detailed with the introduction of two intermediate categories ("intermediate, locally aggressive" and "intermediate, rarely metastasizing").
  • Previously established terms such as "malignant fibrous histiocytoma" or "hemangiopericytoma" will be used much less often in future, because these tumor types have been reinterpreted.
  • The WHO recommends that highly differentiated liposarcoma be renamed "atypical lipomatous tumor."
  • The importance of molecular tumor characterization for individually tailored therapy is already becoming clear.
  • CONCLUSIONS: Optimal diagnosis is the prerequisite for effective therapy and can be achieved only with state-of-the-art knowledge of the pathology of soft tissue tumors.
  • [MeSH-major] Soft Tissue Neoplasms / classification. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19890408.001).
  • [ISSN] 1866-0452
  • [Journal-full-title] Deutsches Ärzteblatt international
  • [ISO-abbreviation] Dtsch Arztebl Int
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2770206
  • [Keywords] NOTNLM ; biopsy / cancer diagnosis / molecular biology / molecular medicine / soft-tissue sarcoma
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98. Sleijfer S, Ray-Coquard I, Papai Z, Le Cesne A, Scurr M, Schöffski P, Collin F, Pandite L, Marreaud S, De Brauwer A, van Glabbeke M, Verweij J, Blay JY: Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol; 2009 Jul 1;27(19):3126-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043).
  • PURPOSE Given the importance of angiogenesis in soft tissue sarcoma (STS), pazopanib, an oral angiogenesis inhibitor that targets vascular endothelial growth factor receptor and platelet-derived growth factor receptor, was explored in patients with advanced STS.
  • PATIENTS AND METHODS Patients with intermediate- or high-grade advanced STS who were ineligible for chemotherapy or who had received no more than two prior cytotoxic agents for advanced disease, who had documented progression, who had adequate performance status, and who had good organ function were eligible.
  • Four different strata were studied: adipocytic STS, leiomyosarcomas, synovial sarcomas, and other STS types.
  • The adipocytic STS stratum was closed after the first stage, given insufficient activity (PFR(12 weeks), five [26%] of19).
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Pyrimidines / therapeutic use. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy. Sulfonamides / therapeutic use
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality

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  • (PMID = 19451427.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Pyrimidines; 0 / Sulfonamides; 7RN5DR86CK / pazopanib
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99. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • We report herein an unusual infiltrating intramuscular spindle cell lipoma arising in the nose of a 53-year-old man.
  • Histologically, a proliferation of mature adipocytes, ropey collagen fibers and spindle cells within a myxoid stroma was present in the subcutaneous tissue and infiltrated between skeletal muscle fibers.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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100. Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, Van Belle PA, Xu X, Elder DE, Herlyn M: A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res; 2005 Oct 15;65(20):9328-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent studies suggest that cancer can arise from a cancer stem cell (CSC), a tumor-initiating cell that has properties similar to those of stem cells.
  • Individual cells from melanoma spheres (melanoma spheroid cells) could differentiate under appropriate conditions into multiple cell lineages, such as melanocytic, adipocytic, osteocytic, and chondrocytic lineages, which recapitulates the plasticity of neural crest stem cells.
  • [MeSH-minor] Animals. Antigens, CD20 / biosynthesis. Cell Adhesion. Cell Differentiation. Cell Line, Tumor. Fibroblasts / cytology. Flow Cytometry. Humans. Mice. Mice, SCID. Neoplasm Transplantation. Spheroids, Cellular. Transplantation, Heterologous

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  • (PMID = 16230395.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA10815; United States / NCI NIH HHS / CA / CA25874; United States / NCI NIH HHS / CA / CA76674; United States / NCI NIH HHS / CA / CA80999
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20
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