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1. Xu Y, Wang J, Peng Y, Zeng J: CT characteristics of primary retroperitoneal neoplasms in children. Eur J Radiol; 2010 Sep;75(3):321-8
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  • [Title] CT characteristics of primary retroperitoneal neoplasms in children.
  • Primary retroperitoneal neoplasms are uncommon in children.
  • Retroperitoneal neoplasms are either mesodermal, neurogenic, germ cell ectodermal or lymphatic in origin.
  • In general, primary retroperitoneal neoplasms in children have different spectrum and prevalence compared to those in adults.
  • Neuroblastoma, rhabdomyosarcoma, benign teratoma and lymphoma are the common retroperitoneal neoplasms.
  • In this review, the clinical and CT futures of common retroperitoneal neoplasms in children are described.
  • In children, lipoblastoma is the most common lipomatous tumor in the retroperitoneum.
  • The percentage of visible fat in tumor varies depending on the cellular composition of the lesion.
  • In conclusion, making a final histological diagnosis of retroperitoneal tumor base on CT features is not often possible; however, CT can help to develop a differential diagnosis and determine the size and extent of the retroperitoneal neoplasms.
  • [MeSH-major] Retroperitoneal Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • [Copyright] Copyright © 2010. Published by Elsevier Ireland Ltd.
  • (PMID = 20591598.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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2. Michaelidis IG, Stefanopoulos PK, Sambaziotis D, Zahos MA, Papadimitriou GA: Sialolipoma of the parotid gland. J Craniomaxillofac Surg; 2006 Jan;34(1):43-6
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  • A case of slow-enlarging mass of the parotid region in a 44-year-old male is presented, which proved to be a lipomatous tumour of the parotid gland.
  • The clinical impression was that of a benign salivary gland tumour.
  • The tumour was situated in the deep lobe of the gland, thus a total parotidectomy was performed, with preservation of the facial nerve.
  • Microscopically the lesion was described as consisting of mature adipose tissue, which, however, encompassed both glandular elements and nerve bundles within it.
  • This tumour has been recently recognized as a separate entity under the term 'sialolipoma'.
  • [MeSH-major] Lipoma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Facial Nerve / pathology. Follow-Up Studies. Humans. Male. Parotid Gland / innervation

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  • (PMID = 16343917.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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3. Aftab S, Casey A, Tirabosco R, Kabir SR, Saifuddin A: Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review. Skeletal Radiol; 2010 Oct;39(10):1039-42
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  • [Title] Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review.
  • Solitary fibrous tumour (SFT) is a rare soft tissue tumour of uncertain histogenesis and unpredictable biological behaviour, which was first described in the pleura and subsequently in many extra-pleural locations.
  • We present the clinical, radiological and histological features of a case of intraspinal fat-forming SFT, along with a literature review.
  • This is the first known report of a fat-forming SFT in the spine.
  • [MeSH-major] Solitary Fibrous Tumors / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hemangiopericytoma / diagnosis. Hemangiopericytoma / surgery. Humans. Lipoma / diagnosis. Lipoma / surgery. Magnetic Resonance Imaging / methods. Male. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20628877.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] Lipomatous hemangiopericytoma
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4. Biernat W, Zakrzewski K, Polis L, Liberski PP: Glioneuronal-mesenchymal tumour with malignant transformation. Folia Neuropathol; 2007;45(3):140-3
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  • [Title] Glioneuronal-mesenchymal tumour with malignant transformation.
  • We report a case of a 10-year-old girl with a tumour of the right temporoparietal region of the brain.
  • The tumour consisted of three morphologically distinct portions: a well-differentiated one containing a mixture of a ganglioglioma with adipocytic-like cells and focal chondroid metaplasia, a separate island with neurocytic differentiation, and the malignant one, which exhibited an organoid pattern (trabecular and festooned) of primitive neuroectodemal tumour (PNET).
  • We hypothesize that the latter component originated from the multicomponental glioneuronal tumour with mesenchymal differentiation and thus that lesion constituted an unusual example of malignant transformation of low-grade glioneuronal neoplasm.

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  • (PMID = 17849365.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
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5. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • We present a rare atypical lipomatous tumour with spindle cell features (synonym: well-differentiated spindle cell liposarcoma) arising on the left palm of a 54-year-old male patient.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • However, focally, atypia of adipocytic and stromal cells as well as scattered lipoblasts were noted, and immunohistochemical stainings showed focal overexpression of MDM 2 and CDK4.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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6. Jaovisidha S, Suvikapakornkul Y, Woratanarat P, Subhadrabandhu T, Nartthanarung A, Siriwongpairat P: MR imaging of fat-containing tumours: the distinction between lipoma and liposarcoma. Singapore Med J; 2010 May;51(5):418-23
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  • INTRODUCTION: This study aimed to retrospectively review the magnetic resonance (MR) imaging features of the lipomatous tumour in order to differentiate between lipoma and liposarcoma.
  • The images were assessed for the number, site, size and margin of the lesions, as well as the signal intensity (homogenous, bright signal on T1-weighted [T1W] image, bright signal suppressed on T1W with fat-suppression image, bright signal on T2-weighted with fat-suppression image), the internal architecture (thin/thick septum, cystic change), the effect on the surrounding tissue (oedema, neurovascular involvement) and the enhancement pattern.
  • RESULTS: A partially ill-defined margin, neurovascular involvement, enhancing thick/nodular septum and a partially bright signal intensity on T1W images were statistically significant MR imaging features that favoured a diagnosis of liposarcoma (p-value is less than 0.0001).
  • Male gender, an internal cystic change and surrounding soft tissue oedema increased the risk of liposarcoma approximately 2.8, 3.5 and 3.5 times, respectively, compared with the reference group (lipoma), but this was not a statistically significant finding.
  • CONCLUSION: Statistically significant MR imaging features that favour a diagnosis of liposarcoma included a partially ill-defined margin, neurovascular involvement, enhancing thick/nodular septum, and a partially bright signal intensity on T1W images.
  • [MeSH-major] Lipoma / diagnosis. Liposarcoma / diagnosis. Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Confidence Intervals. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Muscle Neoplasms / diagnosis. Muscle Neoplasms / pathology. Odds Ratio. Retrospective Studies. Risk Factors

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  • (PMID = 20593147.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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7. Rau T, Soeder S, Olk A, Aigner T: Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma. Ann Diagn Pathol; 2006 Oct;10(5):279-82
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  • [Title] Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma.
  • Lipomas are very common benign soft tissue neoplasms.
  • Mature cartilage and bone arising in a lipoma is a rare event and is mostly associated with a parosteal localization of the neoplasm.
  • We describe a new case of osteochondrolipoma showing not only major adipocytic differentiation but also areas of fibrocytic and cartilaginous cell differentiation and bone formation (both endochondral and membranous).
  • The occurrence of at least 4 distinct directions of mesenchymal cell differentiation within a benign neoplasia underlines the concept of multilineage differentiation of pluripotent mesenchymal stem cells.
  • Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue.
  • [MeSH-major] Bone and Bones / pathology. Cartilage / pathology. Lipoma / pathology. Periosteum / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Aged. Cell Differentiation. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Humans. Male. Mesenchymal Stromal Cells / pathology. Ossification, Heterotopic / pathology. Thigh

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  • (PMID = 16979520.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Yiğiter M, Otgün I, Kiyici H, Akkoyun I, Yücesan S, Hiçsönmez A: Chest wall lipoblastomatosis in a 2-year-old girl: a case report and literature review. Turk J Pediatr; 2010 Sep-Oct;52(5):538-41
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  • Lipoblastoma is an uncommon tumor of adipose tissue that usually occurs in infancy and early childhood.
  • In spite of their potential for local invasion and rapid growth, they are benign tumors and have no distant metastasis.
  • We present the case of a two-year-old girl with lipoblastomatosis of the chest wall that was identified by histologic examination.
  • In this article, the English literature on this disorder is briefly reviewed.
  • [MeSH-major] Lipomatosis / pathology. Soft Tissue Neoplasms / pathology. Thoracic Wall

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  • (PMID = 21434542.001).
  • [ISSN] 0041-4301
  • [Journal-full-title] The Turkish journal of pediatrics
  • [ISO-abbreviation] Turk. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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9. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600
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  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.
  • With the aim of both diagnosis and treatment, the lipomatous mass was removed by local resection.
  • In addition to the patient's age, histologic and cytogenetic analyses assisted the diagnosis of diffuse lipoblastoma.
  • [MeSH-major] Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Shimada S, Harada H, Ishizawa K, Hirose T: Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma. Pathol Int; 2006 Oct;56(10):638-41
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  • [Title] Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma.
  • A 16 x 13 cm lipomatous tumor was resected from the perirenal retroperitoneum of a 71-year-old woman.
  • Microscopically, the tumor was exclusively composed of mature adipose tissue and abnormal thick blood vessels, but bundles of smooth muscle were lacking.
  • Real-time polymerase chain reaction failed to demonstrate the amplification of the murine double-minute type 2 gene and cyclin-dependent kinase 4 gene in this tumor.
  • Therefore, the tumor was diagnosed as lipomatous angiomyolipoma.
  • After the diagnosis, it was found that the patient had multiple myeloma and cardiac amyloidosis, suggesting that the amyloid deposition within the tumor was a complication of the myeloma.
  • Lipomatous angiomyolipoma may be a diagnostic pitfall of retroperitoneal lipomatous tumors.
  • [MeSH-major] Amyloid / metabolism. Angiomyolipoma / diagnosis. Angiomyolipoma / metabolism. Liposarcoma / diagnosis. Liposarcoma / metabolism. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / metabolism
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase 4 / genetics. Cyclin-Dependent Kinase 4 / metabolism. Diagnosis, Differential. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism

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  • (PMID = 16984623.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Amyloid; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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11. Ma X, Ren X, Han P, Hu S, Wang J, Yin J: SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction. Mol Biol Rep; 2010 Dec;37(8):4003-11
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  • [Title] SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction.
  • Fatty acid-binding protein 5 (Fabp5), exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport.
  • 3T3-L1 preadipocytes were selected as cell differentiation model and short interfering RNAs (siRNA) against Fabp5 (siFabp5) were prepared.
  • However, during adipocytic induction, 3T3-L1 preadipocytes transfected with siFabp5 significantly reduced cell viability, as well as increased both caspase-3 activity and procaspase-3 cleavage.
  • Furthermore, we illustrated that knockdown Fabp5 inhibited the expression of PPARγ and C/EBPα during adipocytic induction.
  • [MeSH-major] Adipocytes / cytology. Adipocytes / metabolism. Apoptosis. Cell Differentiation. Fatty Acid-Binding Proteins / metabolism. Neoplasm Proteins / metabolism. RNA, Small Interfering / metabolism

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  • (PMID = 20238174.001).
  • [ISSN] 1573-4978
  • [Journal-full-title] Molecular biology reports
  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Protein-alpha; 0 / Fabp5 protein, mouse; 0 / Fatty Acid-Binding Proteins; 0 / Neoplasm Proteins; 0 / PPAR gamma; 0 / RNA, Messenger; 0 / RNA, Small Interfering; EC 3.4.22.- / Caspase 3
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12. Farah-Klibi F, Ferchichi L, Zaïri I, Rammeh S, Adouani A, Jilani SB, Zermani R: Lipomatous hemangiopericytoma (adipocytic variant of solitary fibrous tumor) of the orbit. A case report with review of the literature. Pathologica; 2006 Dec;98(6):645-8
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  • [Title] Lipomatous hemangiopericytoma (adipocytic variant of solitary fibrous tumor) of the orbit. A case report with review of the literature.
  • Hemangiopericytoma (HPC) of the orbit is a rare tumor presenting with slowly progressive proptosis, ocular motility impairment and visual loss.
  • In 1995, a newly variant of HPC termed lipomatous hemangiopericytoma (LHPC), was described.
  • The authors describe another case of orbital LHPC and discuss the clinicopathologic features, including the immunohistochemical staining profile and ultrastructural appearance of this distinctive tumor, and briefly discuss the relationship between HPC and solitary fibrous tumor of soft tissue, a neoplasm with many clinical and pathologic similarities.
  • [MeSH-major] Hemangiopericytoma / pathology. Lipoma / pathology. Orbital Neoplasms / pathology

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  • (PMID = 17285842.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 11
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13. Sadeghian H, Eslami B, Shirani S, Sadeghian A: Lipomatous tumor of the tricuspid valve: report of a rare case. J Heart Valve Dis; 2009 Nov;18(6):720-2
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  • [Title] Lipomatous tumor of the tricuspid valve: report of a rare case.
  • The case is reported of a 19-year-old man with cardiac valve lipomatosis which was accidentally discovered during the work-up for an atypical chest pain.
  • Magnetic resonance imaging showed evidence of tricuspid valve lipomatosis, a rare cardiac valve tumor.
  • After five months, echocardiography showed that the mass had not grown.
  • To the best of the present authors' knowledge, very few reports exist of cardiac valve lipomatous tumors.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Lipoma / ultrasonography. Tricuspid Valve / ultrasonography

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  • (PMID = 20099724.001).
  • [ISSN] 0966-8519
  • [Journal-full-title] The Journal of heart valve disease
  • [ISO-abbreviation] J. Heart Valve Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Fernandes H, Naik CN, Swethadri GK, Bangera I, Miranda D: Pure lipoma of the uterus: a rare case report. Indian J Pathol Microbiol; 2007 Oct;50(4):800-1
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  • Pure fatty tumors of the uterus are exceedingly rare.
  • The more common lipomatous tumor is lipoleiomyoma with varying amounts of two components.
  • Computed Tomography and Magnetic Resonance Imaging can assist in pre-operative diagnosis.
  • Ultrasound revealed fibroid uterus with lipomatous areas.
  • As clinical symptoms and signs of uterine lipoma are indistinguishable from uterine leiomyoma, various imaging techniques can aid in pre-operative diagnosis.
  • The diagnosis of pure lipoma of the uterus should only be made when any smooth muscle if present is confined to the periphery of the tumor.
  • [MeSH-major] Lipoma / diagnosis. Lipoma / pathology. Uterine Neoplasms / diagnosis. Uterine Neoplasms / pathology
  • [MeSH-minor] Abdomen / ultrasonography. Diagnosis, Differential. Female. Humans. Hysterectomy. Leiomyoma / diagnosis. Leiomyoma / pathology. Middle Aged. Uterus / pathology

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  • (PMID = 18306560.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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15. Casanova Espinosa A, Cisneros Serrano C, Girón Moreno RM, Olivera MJ, Moreno Balsalobre R, Zamora García E: [Pleural empyema associated with endobronchial lipoma]. Arch Bronconeumol; 2005 Mar;41(3):172-4
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  • Bronchial benign tumors comprise fewer than 4% of pulmonary neoplasms.
  • Endobronchial lipoma is an extremely rare benign neoplasm accounting for only 0.1% to 0.5% of all lung tumors.
  • Clinical symptoms of lipoma depend on the location of the tumor, the severity of bronchial obstruction, and the functional and anatomical effects on the parenchyma distal to the obstruction.
  • Computed axial tomography usually reveals the adipose composition of the lipomatous tumor.
  • We report the case of an 83-year-old man diagnosed with community-acquired pneumonia that led to complications: pleural empyema caused by Haemophilus influenzae infection and atelectasis of the right middle and lower lobes secondary to a lipomatous endobronchial obstruction.
  • [MeSH-major] Bronchial Neoplasms / complications. Empyema, Pleural / etiology. Lipoma / complications

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  • (PMID = 15766470.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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16. Miller DV, Tazelaar HD: Cardiovascular pseudoneoplasms. Arch Pathol Lab Med; 2010 Mar;134(3):362-8
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  • CONTEXT: Primary cardiac tumors are rare and the great majority are benign neoplasms.
  • Mass-forming reactive and pseudoneoplastic growths are less common, but recognizing and distinguishing these lesions from the neoplasms they resemble is critical to appropriate patient care.
  • OBJECTIVE: The general clinical, imaging, gross pathologic, and histologic features of 5 important pseudoneoplasms (inflammatory myofibroblastic tumor, hamartoma of mature cardiac myocytes, mesothelial/monocytic cardiac excrescences, calcified amorphous tumor, and lipomatous hypertrophy of the atrial septum) are discussed, with an emphasis on features differentiating them from other benign and malignant tumors.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Arch Pathol Lab Med. 2010 Nov;134(11):1584-6 [21043810.001]
  • (PMID = 20196664.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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17. Weaver J, Downs-Kelly E, Goldblum JR, Turner S, Kulkarni S, Tubbs RR, Rubin BP, Skacel M: Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol; 2008 Aug;21(8):943-9
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  • [Title] Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms.
  • Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas, respectively.
  • Cytogenetics in these tumors has identified ring and giant chromosomes composed of 12q13-15 amplicons including the MDM2 gene.
  • Identifying MDM2 amplification by fluorescence in situ hybridization may prove an adjunctive tool in the diagnosis of lipomatous neoplasms.
  • Dual color fluorescence in situ hybridization employing a laboratory-developed BAC label probe cocktail specific for MDM2 (12q15) and a probe for the centromeric region of chromosome 12 (Abbott Molecular, DesPlaines, IL) was performed on formalin-fixed and paraffin-embedded tissue including whole sections from atypical lipomatous tumors (n=13), dedifferentiated liposarcomas (n=14), benign lipomatous tumors (n=30), and pleomorphic sarcoma, not otherwise specified (n=10), and a tissue microarray containing a variety of high-grade sarcomas (n=63).
  • MDM2/chromosome 12 fluorescence in situ hybridization is a sensitive and specific tool (both 100%) in evaluating low-grade lipomatous neoplasms.
  • Importantly, none of the benign lipomatous lesions were MDM2 amplified and even cells in areas of well-differentiated liposarcomas with minimal cytologic atypia were amplified, making the probe a valuable tool in the diagnosis of even limited biopsy samples of well-differentiated lipomatous neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Lipoma / genetics. Liposarcoma / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Aneuploidy. Chromosomes, Human, Pair 12. Gene Amplification. Humans. Nucleic Acid Amplification Techniques. Tissue Array Analysis

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  • (PMID = 18500263.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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18. Milczarek R, Klimek J: [Aromatase--key enzyme of estrogen biosynthesis]. Postepy Biochem; 2005;51(4):430-9
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  • It was pointed that unique human CYP19 gene expression results from presence of many tissue specific promoters and alternative splicing.
  • The molecular mechanism of control aromatase cytochrome P450 gene expression in various species ovaries, testes and human adipose tissue and placenta was discussed in details.
  • Because of a very important role of estrogen in breast cancer a molecular base of aberrant expression CYP19 gene in breast tumor and adipose tissue proximal to breast tumor and potential possibility of pharmacological silencing of this gene expression was discussed in the article.
  • [MeSH-minor] Adipose Tissue / metabolism. Animals. Antineoplastic Agents / pharmacology. Bone Development / physiology. Breast Neoplasms / drug therapy. Breast Neoplasms / genetics. Breast Neoplasms / metabolism. Female. Fertility / physiology. Gene Expression / drug effects. Humans. Male. Placenta / metabolism. Reproduction / physiology

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  • (PMID = 16676578.001).
  • [ISSN] 0032-5422
  • [Journal-full-title] Postepy biochemii
  • [ISO-abbreviation] Postepy Biochem.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Estrogens; EC 1.14.14.1 / Aromatase
  • [Number-of-references] 66
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19. Horton SC, Nay S, Gonzales M, McIntosh M, Hammond E, Clayson S: Smooth muscle neoplasm presenting as intrapericardial myxoma. J Am Soc Echocardiogr; 2006 Jun;19(6):835.e1-3
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  • [Title] Smooth muscle neoplasm presenting as intrapericardial myxoma.
  • The tumor was a globular mass attached to the left atrium by a stalk, suggestive of a myxoma.
  • Histology revealed a smooth muscle tumor with extensive adipocytic differentiation and numerous small blood vessels.
  • This study represents the first echocardiographic description of a smooth muscle tumor presenting as an extracardiac myxoma.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Muscle Neoplasms / ultrasonography. Muscle, Smooth, Vascular / ultrasonography. Myxoma / ultrasonography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 16762765.001).
  • [ISSN] 1097-6795
  • [Journal-full-title] Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
  • [ISO-abbreviation] J Am Soc Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. González I, Vicent S, de Alava E, Lecanda F: EWS/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model. J Mol Med (Berl); 2007 Sep;85(9):1015-29
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  • Ewing sarcoma/primitive neuroectodermal tumors (EWS/PNET) are characterized by specific chromosomal translocations most often generating a chimeric EWS/FLI-1 gene.
  • Furthermore, EWS/FLI-1 expression blocked mineralization, with concomitant repression of osteoblastic genes, and induced a dramatic repression of the adipocytic differentiation program.
  • Moreover, EWS/FLI-1 promoted an aberrant neural phenotype by the de novo expression of specific neural genes.
  • The intramuscular injection of transduced cells led to tumor development and the induction of overt osteolytic lesions.
  • Analogously, to what was observed in human tumors, type 2 EWS/FLI-1 cells formed primary tumors in immunodeficient mice with a higher incidence and a lower latency than cells bearing types 1 and 3 fusions.
  • By contrast, cells expressing types 2 and 3 fusions showed specific metastatic activity with a higher number of macroscopic metastases in soft tissues and osteolytic lesions in the limbs as compared to type-1-expressing cells.
  • Thus, this model provides a basis for understanding the genetic determinants involved in Ewing tumor development and metastatic activity and represents a cellular system to analyze other oncoproteins involved in human sarcomagenesis.
  • [MeSH-minor] Animals. Blotting, Western. Cell Line. Cell Line, Tumor. Cell Proliferation. Female. Flow Cytometry. Fluorescent Antibody Technique. Humans. Mice. Mice, Inbred C3H. Mice, Nude. Microscopy, Electron, Scanning. Neoplasm Metastasis. RNA-Binding Protein EWS. Radiography. Reverse Transcriptase Polymerase Chain Reaction. Sarcoma, Experimental / diagnostic imaging. Sarcoma, Experimental / genetics. Sarcoma, Experimental / pathology. Transplantation, Heterologous

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  • (PMID = 17453169.001).
  • [ISSN] 0946-2716
  • [Journal-full-title] Journal of molecular medicine (Berlin, Germany)
  • [ISO-abbreviation] J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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21. Siddiqui MK, Jyoti, Singh S, Mehrotra PK, Singh K, Sarangi R: Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study. Environ Int; 2006 Jul;32(5):630-7
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  • [Title] Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study.
  • Fifty women residing in and around New Delhi, India and identified to have benign (25 nos.) and malignant (25 nos.) breast lesions were studied for the first time to access the association between environmental exposure to lead and risk of breast cancer and to determine the potential of changes in trace elements concentration as a diagnostic marker and/or its etiological involvement in the disease.
  • Blood, tumor tissue and breast adipose tissue from tumor free area from each patient of the two groups, collected at the time of lumpectomy or mastectomy (only blood sample was collected from disease free control group), were analyzed to determine the concentration of Pb, Zn, Cu, Fe and Ca using Atomic Absorption Spectrometry.
  • Lead level was also higher in tumor tissue when compared with their respective normal tumor free breast tissue, though non-significant, in both benign and malignant cases.
  • Furthermore, these metals were also higher in tumor of malignant and benign cases as compared to normal tumor free breast tissue, many of them statistically significant (p<0.05/0.01/0.001).
  • However, Cu level was insignificantly lower in the blood and tumor tissue of malignant cases when compared with their benign counterparts while it was significantly higher (p<0.05) in tumor of benign cases when compared with those of their respective normal tumor free breast tissue.
  • There were statistically significant correlations between lead and trace element levels only in normal tumor free breast tissue of benign and malignant cases (r=0.41-0.73; p<0.05-0.001) but neither in blood nor tumor tissue of the two groups.
  • Further, modulation of trace elements level in both benign and malignant breast diseases patients may be of potential to be used as diagnostic marker of the disease process and its possible relationship etiologically.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Mammary Glands, Human / metabolism. Trace Elements / blood

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  • (PMID = 16580070.001).
  • [ISSN] 0160-4120
  • [Journal-full-title] Environment international
  • [ISO-abbreviation] Environ Int
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Trace Elements
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22. Nahal A, Meterissian S: Lipoleiomyosarcoma of the rectosigmoid colon: a unique site for a rare variant of liposarcoma. Am J Clin Oncol; 2009 Aug;32(4):353-5
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  • OBJECTIVES: Soft tissue tumors with dual adipocytic and smooth muscle differentiation are generally rare with most being benign.
  • Sarcomas with dual fatty and smooth muscle differentiation are even rarer.
  • The purpose of this paper is to discuss a rare presentation of a lipoleiomyosarcoma and review, the method of pathologic diagnosis and the literature.
  • METHODS: Detailed clinical and histopathologic review of a clinical case and review of the literature using PUBMED for publications on lipoleiomyosarcoma.
  • Pathologic diagnosis requires immunohistochemical staining with MDM2 and CDK4.
  • Its diagnosis requires immunohistochemistry and awareness of its possible existence.
  • [MeSH-major] Leiomyosarcoma / pathology. Liposarcoma / pathology. Neoplasm Invasiveness / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Colectomy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Laparotomy / methods. Middle Aged. Neoplasm Staging. Pelvic Pain / diagnosis. Pelvic Pain / etiology. Radiotherapy, Adjuvant. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19363435.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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23. Nishida J, Ehara S, Shiraishi H, Tada H, Satoh T, Okada K, Shimamura T: Clinical findings of hibernoma of the buttock and thigh: rare involvements and extremely high uptake of FDG-PET. Med Sci Monit; 2009 Jul;15(7):CS117-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Hibernoma is a rare adipose tissue tumor of the soft tissue and the term is derived from the histological similarities to the brown fat found in hibernating animals.
  • This was not typical of liposarcoma and suggestive of hibernoma.
  • Biopsy specimens revealed a proliferation of adipose cells with vacuolated granular eosinophilic cytoplasm.
  • CONCLUSIONS: While occurrences in the buttock or thigh are exceedingly rare, hibernoma should be included in the differential diagnosis of an adipose tissue tumor in the thigh, even though the imaging findings mimic liposarcoma.
  • A correct diagnosis should be established to prevent over-surgery.

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  • (PMID = 19564831.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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24. Marsilia GM, Boscaino A, La Mura A, Ceriello A, De Ritis R: Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? Int J Surg Pathol; 2010 Dec;18(6):537-9
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  • Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45.
  • The tumor cells of intramural small intestinal mass were positive for S-100 protein and GFAP and negative for CD117, CD34 and desmin.
  • [MeSH-major] Angiomyolipoma / pathology. Jejunal Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19282295.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Therefore, an accurate preoperative diagnosis is very important for proper treatment.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. Saifzadeh S, Derakhshanfar A, Hadian M: Congenital lipoblastoma in a neonate calf: first report in veterinary literature. Vet Dermatol; 2007 Apr;18(2):130-3
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  • Lipoblastoma is a rare benign tumour of adipose tissue that usually occurs in young children.
  • This case report describes the clinical and histopathological findings of a congenital lipoblastoma located at the tail base of a 2-day-old male calf.
  • Lipoblastoma should thus be considered in the differential diagnosis list for congenital adipose tissue tumours in animals.
  • [MeSH-major] Cattle Diseases / diagnosis. Lipoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Animals, Newborn. Cattle. Diagnosis, Differential. Male. Tail

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  • (PMID = 17355429.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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27. Vicioso L, Gallego E, Sanz A: Cutaneous mixed tumor with lipomatous stroma. J Cutan Pathol; 2006 Sep;33 Suppl 2:35-8
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  • [Title] Cutaneous mixed tumor with lipomatous stroma.
  • AIM: Mixed tumors are usually composed of two components, one epithelial and the other mesenchymal.
  • The latter component is commonly myxoid or myxochondroid; a massively lipomatous stroma is very unusual.
  • To date, only two cases of mixed tumor of the skin have been reported with this type of stroma.
  • METHODS AND RESULTS: We report the case of a 61-year-old man with a mixed tumor situated on the hand, an unusual site for these tumors, with over 90% of the tumor composed of adipose tissue.
  • The tumor was a well-circumscribed, 4.5-cm mass, with the gross appearance of a lipoma.
  • The lipomatous stroma contained nests and ribbons of epithelial cells, with occasional tubular structures, surrounded by a scarce amount of fibromyxoid tissue.
  • Immunohistochemical study showed findings similar to those seen in classic mixed tumors.
  • CONCLUSION: Together with a few other cases in the skin and parotid gland, this report shows how massive adipose differentiation can arise in a mixed tumor of the skin.
  • [MeSH-major] Adipose Tissue / pathology. Fibroma / pathology. Mixed Tumor, Malignant / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Differentiation. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16972952.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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28. Dutton JJ, Wright JD Jr: Intramuscular lipoma of the superior oblique muscle. Orbit; 2006 Sep;25(3):227-33
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  • We describe a rare intramuscular infiltrating lipomatous tumor affecting the superior oblique muscle.
  • Biopsy showed an infiltrative tumor consisting of adipocytes with included degenerated muscle fibers.
  • Lipomas are common tumors that usually do not cause functional impairment but are very rare in the orbit.
  • Enlargement of an extraocular or periorbital muscle with a low-density infiltrating lesion should raise suspicion for this unusual tumor.
  • [MeSH-major] Lipoma / pathology. Muscle Neoplasms / pathology. Oculomotor Muscles

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  • (PMID = 16987771.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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29. Kocaoğlu B, Erol B, Yalçin S, Bozkurt S, Altun E: Pediatric diffuse lipoblastomatosis of the foot -- a case report and review of the literature. Eur J Pediatr Surg; 2006 Jun;16(3):217-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diffuse lipoblastomatosis is a rare lipomatous tumor of infancy that derives from fetal-embryonal fat.
  • In spite of its benign nature, the tumor may behave in a locally aggressive manner and invade the surrounding tissues.
  • A case of isolated diffuse lipoblastomatosis of a 5-year-old boy in the plantar aspect of his right foot that has not been documented in that area before is described.
  • The clinical and radiological presentation and histologic evaluation of diffuse lipoblastomatosis are discussed, in order to make a differential diagnosis between this rare tumor and other soft tissue tumors.
  • In addition, the treatment principles of the tumor are described.
  • [MeSH-major] Foot Diseases / diagnosis. Lipoma / diagnosis

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  • (PMID = 16909365.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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30. de Saint Aubain Somerhausen N, Coindre JM, Debiec-Rychter M, Delplace J, Sciot R: Lipoblastoma in adolescents and young adults: report of six cases with FISH analysis. Histopathology; 2008 Feb;52(3):294-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIMS: Lipoblastoma is a rare benign adipocytic neoplasm that occurs primarily in infancy and early childhood.
  • Histologically, there is some morphological overlap with atypical lipomatous tumour and myxoid liposarcoma and the age at presentation is often regarded as a major diagnostic criterion.
  • CONCLUSIONS: Lipoblastoma occurs rarely in young adults and should enter into the differential diagnosis of 'atypical' fatty tumours in adults.
  • [MeSH-major] DNA, Neoplasm / analysis. In Situ Hybridization, Fluorescence. Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Adolescent. Adult. Chromosome Aberrations. Disease-Free Survival. Female. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 18269579.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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31. Kumazoe H, Nagamatsu Y, Nishi T, Kimura YN, Nakazono T, Kudo S: Dumbbell-shaped thoracic hibernoma: computed tomography and magnetic resonance imaging findings. Jpn J Radiol; 2009 Jan;27(1):37-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Hibernoma is an uncommon, benign soft tissue tumor that arises in brown adipose tissue.
  • We report the unique appearance of a rare thoracic wall hibernoma, which appeared as a dumbbell-shaped lipomatous tumor across an intercostal region.
  • [MeSH-major] Lipoma / diagnostic imaging. Soft Tissue Neoplasms / diagnostic imaging

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  • [Cites] Am J Surg Pathol. 2001 Jun;25(6):809-14 [11395560.001]
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  • (PMID = 19373530.001).
  • [ISSN] 1867-1071
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. López-Ferrer P, Jiménez-Heffernan JA, Yébenes L, Vicandi B, Viguer JM: Fine-needle aspiration cytology of lipoblastoma: a report of two cases. Diagn Cytopathol; 2005 Jan;32(1):32-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma is an uncommon lipomatous tumor that typically occurs in infants and children.
  • Smears showed fragments of adipose tissue that consisted of numerous vacuolated adipocytes with few stroma.
  • Myxoid stromal material was a remarkable finding in one case.
  • Cytologic features were characteristic enough to permit a specific diagnosis (adipose tumor suggestive of lipoblastoma).
  • The differential diagnosis should consider lipoma with regressive changes, well-differentiated and mixoid liposarcoma.
  • In addition to cytologic features, the patient's age is very useful for differentiation.
  • [MeSH-major] Adipocytes / pathology. Biopsy, Fine-Needle / methods. Lipoma / pathology. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15584040.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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33. Honoki K, Morita K, Kasai T, Fujii H, Kido A, Tsukamoto S, Nonomura A, Tanaka Y: Hibernoma of the axillary region: a rare benign adipocytic tumor. Rare Tumors; 2010;2(1):e7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hibernoma of the axillary region: a rare benign adipocytic tumor.
  • Hibernoma is a rare benign tumor considered to arise from remnants of fetal brown adipose tissue.
  • Clinicallywell, hibernomas are slow-growing, asymptomatic tumors.
  • However, unlike lipomas, MRI findings sometimes mislead clinicians to diagnose a malignant neoplasm.

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  • (PMID = 21139952.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994483
  • [Keywords] NOTNLM ; adipocytic tumor / brown fat / hibernoma
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34. Cheng H, Dodge J, Mehl E, Liu S, Poulin N, van de Rijn M, Nielsen TO: Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays. Hum Pathol; 2009 Sep;40(9):1244-51
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  • [Title] Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays.
  • Expression profiling followed by tissue microarray validation linked to patient outcome is a powerful approach for validating biological mechanisms and identifying prognostic biomarkers.
  • We applied these techniques to independent series of primary myxoid liposarcomas in an effort to assess markers of adipose differentiation in myxoid liposarcoma and to identify prognostic markers that can be efficiently assessed by immunohistochemistry.
  • Candidate genes were selected based on analysis of expression profiles from 9 primary myxoid/round liposarcomas and 45 other soft tissue tumors, and by reference to publicly available data sets.
  • Protein products were validated on an adipose neoplasm tissue microarray, including 32 myxoid liposarcomas linked to patient outcome.
  • [MeSH-major] Adipogenesis. Biomarkers, Tumor / analysis. Liposarcoma, Myxoid / genetics. Soft Tissue Neoplasms / genetics. Tissue Array Analysis / methods


35. Eberhardt M, Salmon P, von Mach MA, Hengstler JG, Brulport M, Linscheid P, Seboek D, Oberholzer J, Barbero A, Martin I, Müller B, Trono D, Zulewski H: Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets. Biochem Biophys Res Commun; 2006 Jul 07;345(3):1167-76
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  • In accordance with a mesenchymal phenotype, the cells were also able to adopt adipocytic or osteocytic phenotypes in vitro.
  • [MeSH-major] Homeodomain Proteins / physiology. Intermediate Filament Proteins / physiology. Islets of Langerhans / cytology. Mesenchymal Stromal Cells / cytology. Nerve Tissue Proteins / physiology
  • [MeSH-minor] ATP Binding Cassette Transporter, Sub-Family G, Member 2. ATP-Binding Cassette Transporters / metabolism. Adipocytes / metabolism. Albumins / metabolism. Cell Culture Techniques / methods. Cell Differentiation. Humans. LIM-Homeodomain Proteins. Lentivirus / metabolism. Neoplasm Proteins / metabolism. Nestin. Neurons / metabolism. Osteoblasts / metabolism. Transcription Factors

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  • (PMID = 16713999.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / ATP Binding Cassette Transporter, Sub-Family G, Member 2; 0 / ATP-Binding Cassette Transporters; 0 / Albumins; 0 / Homeodomain Proteins; 0 / Intermediate Filament Proteins; 0 / LIM-Homeodomain Proteins; 0 / NES protein, human; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 0 / Transcription Factors; 0 / insulin gene enhancer binding protein Isl-1
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36. Mariño-Enríquez A, Fletcher CD, Dal Cin P, Hornick JL: Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol; 2010 Aug;34(8):1122-31
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  • [Title] Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria.
  • Dedifferentiated liposarcoma (LPS) is a malignant adipocytic neoplasm defined as the transition from well-differentiated LPS to a nonlipogenic sarcoma.
  • Heterologous differentiation is seen in 5% to 10% of dedifferentiated LPS, usually with myogenic or osteo/chondrosarcomatous elements.
  • Adipocytic differentiation in the dedifferentiated component is incompatible with the current definition of dedifferentiated LPS.
  • The tumors arose in the retroperitoneum (7), proximal lower extremity (3), chest wall (1), and neck (1) of 9 males and 3 females (median age 66 y; range 49 to 76).
  • Four cases were composed exclusively of pleomorphic LPS-like areas developing in 1 of the recurrences or metastases of a prior typical dedifferentiated LPS.
  • Two cases also showed heterologous smooth muscle differentiation.
  • Thus far, 5 patients have died of disease, 3 are alive with recurrent or metastatic disease, and 3 are alive with no evidence of disease.
  • We conclude that dedifferentiated LPS can show lipoblastic differentiation in the high-grade component, resulting in areas indistinguishable from pleomorphic LPS.
  • The available clinical and molecular data support the notion of "homologous" lipoblastic differentiation in dedifferentiated LPS, rather than mixed-type LPS.
  • [MeSH-major] Adipocytes / pathology. Biomarkers, Tumor. Cell Dedifferentiation. Liposarcoma / diagnosis
  • [MeSH-minor] Aged. Chromosomes, Human, Pair 12. Cyclin-Dependent Kinase 4 / analysis. Diagnosis, Differential. Female. HMGA2 Protein / genetics. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Karyotyping. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Predictive Value of Tests. Proto-Oncogene Proteins c-mdm2 / analysis. Terminology as Topic. Time Factors. Treatment Outcome

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  • (PMID = 20588177.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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37. Ide F, Tanaka A, Kusama K: Further evidence for adipocytic differentiation by the neoplastic myoepithelium. J Oral Pathol Med; 2007 Mar;36(3):187-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Further evidence for adipocytic differentiation by the neoplastic myoepithelium.
  • Lipomatous pleomorphic adenoma (PA)/myoepithelioma is rare.
  • Nevertheless, adipocytic differentiation in salivary gland tumors is a well-known phenomenon.
  • We report here a unique PA that represents an equivocal transition from the epithelioid NME to adipocytes in recurrent lesions but not in a primary tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adipocytes / pathology. Epithelial Cells / pathology. Myoepithelioma / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Differentiation. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 17305642.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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38. Obora A, Kojima T, Kato T, Matsuda H, Horie H, Hashimoto H, Fukuta N, Takano Y, Okuda J, Ida K, Saio M: [An autopsy case of hepatocellular carcinoma in which sarcoma-like changes and peritoneal dissemination were observed after RFA/TACE treatment]. Gan To Kagaku Ryoho; 2009 Jul;36(7):1183-6
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  • Liver biopsy led to a diagnosis of well-differentiated hepatocellular carcinoma.
  • CT revealed pleural effusion/ascites and nodular tumor in the adipose tissue of the parietal peritoneum and mesentery around the liver.
  • Autopsy revealed a tumor involving the liver surface to the peritoneum, suggesting cancerous peritonitis.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Catheter Ablation. Chemoembolization, Therapeutic. Liver Neoplasms / therapy

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  • (PMID = 19620814.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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39. Zhang H, Erickson-Johnson M, Wang X, Oliveira JL, Nascimento AG, Sim FH, Wenger DE, Zamolyi RQ, Pannain VL, Oliveira AM: Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors. Am J Surg Pathol; 2010 Sep;34(9):1304-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors.
  • Ancillary molecular testing has been advocated for diagnostic accuracy in the differentiation of lipomas from atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDL); however, the implications and specific indications for use are not well-established in the current literature.
  • Herein, we extend previous findings by quantitatively evaluating the impact of molecular testing of lipomatous neoplasms in our routine clinical practice, how it modifies the historical perspective of their clinical course, and the effect of distinct surgical procedures in modulating the risk of local recurrence for these tumors after molecular classification.
  • On the basis of these analyses, we suggest a specific set of basic recommendations for complementary molecular assessment in the diagnosis of lipomatous tumors.
  • Four hundred and five lipomatous neoplasms located in the trunk and extremities were analyzed histologically and for the presence of 12q13-15 amplification on paraffin-embedded tissues by assessing MDM2/CPM amplification.
  • The 405 tumors were histologically classified as ordinary lipoma (n=324), intramuscular lipoma (n=29), and ALT/WDL (n=52).
  • The level of agreement between the histologic diagnosis and the molecular diagnosis was high (96%) but pathologists showed a tendency to overestimate cytologic atypia and the diagnosis of ALT/WDL (precision, 79%; accuracy, 88%).
  • Molecular assessment led to a major diagnostic reclassification in 18 tumors (4%).
  • Eleven of the tumors histologically classified as ALT/WDL were reclassified as ordinary lipoma (n=5) and intramuscular lipoma (n=6); none of which recurred.
  • Multivariate analyses after molecular assessment showed tumor type and type of resection to be associated with the risk of local recurrence.
  • Complementary molecular testing refines the histologic classification of lipomatous tumors and better estimates the impact of surgical procedures on the risk of local recurrence.
  • Pathologists tend to overestimate the degree of cytologic atypia and the indiscriminate use of molecular testing should be avoided, especially for extremity-based tumors.
  • Molecular testing should be considered for "relapsing lipomas," tumors with questionable cytologic atypia (even if widely excised), or for large lipomatous tumors (>15 cm) without diagnostic cytologic atypia.
  • [MeSH-major] Lipoma / genetics. Liposarcoma / genetics. Molecular Diagnostic Techniques. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Chromosomes, Human, Pair 12. DNA, Neoplasm / analysis. Disease-Free Survival. Extremities. Female. GPI-Linked Proteins. Gene Amplification. Humans. In Situ Hybridization, Fluorescence. Male. Metalloendopeptidases / genetics. Metalloendopeptidases / metabolism. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism. Treatment Outcome

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  • (PMID = 20679883.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / GPI-Linked Proteins; EC 3.4.17.12 / carboxypeptidase M; EC 3.4.24.- / Metalloendopeptidases; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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40. Cappellani A, Zanghì A, Di Vita M, La Porta D, Alfano G, D'Angelo AF: Very atypical presentation of a retroperitoneal "atypical lipoma". A well differentiated liposarcoma presenting as sciatic hernia. Ann Ital Chir; 2007 Jan-Feb;78(1):69-72
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  • [Title] Very atypical presentation of a retroperitoneal "atypical lipoma". A well differentiated liposarcoma presenting as sciatic hernia.
  • Unlike hernias and neoplasms of any other body site, the sciatic hernia is uncommon and the finding of an atypical lipoma in it is probably unique.
  • In such instance making the correct diagnosis is paramount in order to perform a procedure with a radical intent.
  • A CT scan must be considered any time a rare form of hernia is observed and the surgical treatment of a retroperitoneal lipoma has to be radical, to prevent a recurrence.
  • This is the strategy followed by the authors in a case of a 53 year old lady presenting with a large retroperitoneal lipomatous neoplasm within a sciatic hernia.
  • [MeSH-major] Hernia / etiology. Lipoma / diagnosis. Liposarcoma / diagnosis. Retroperitoneal Neoplasms / diagnosis. Sciatic Nerve
  • [MeSH-minor] Diagnosis, Differential. Female. Herniorrhaphy. Humans. Middle Aged. Treatment Outcome


41. Giannopoulou I, Fernhall B, Carhart R, Weinstock RS, Baynard T, Figueroa A, Kanaley JA: Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes. Metabolism; 2005 Jul;54(7):866-75
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  • Plasma resistin levels were not altered by the 3 interventions from pre- to posttreatment (D: pre = 6.9 +/- 0.6, post = 6.2 +/- 0.4 ng/mL; D + E: pre = 5.6 +/- 0.6, post = 5.7 +/- 0.4 ng/mL; E: pre = 6.2 +/- 0.6, post = 5.9 +/- 0.6 ng/mL, P > .05), and no differences in adiponectin and tumor necrosis factor alpha (TNF- alpha ) levels were found.
  • Visceral adipose tissue and tumor necrosis factor alpha were the only predictors of calculated insulin resistance ( P < .05), explaining 43% of the variability.


42. Brandal P, Bjerkehagen B, Heim S: Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol; 2006 Feb;208(3):388-94
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  • [Title] Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology.
  • Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have different more or less specific chromosomal abnormalities.
  • One such entity is lipoblastoma, which is a benign lipomatous tumour that often exhibits rearrangements of chromosome bands 8q11-13, and the gene PLAG1 has been implicated as the target of these chromosomal changes.
  • All lipomatous tumours karyotyped at the Norwegian Radium Hospital were reviewed, looking for rearrangements of 8q11-13.
  • The findings raise the question as to what extent the diagnosis lipoblastoma should be based on histopathological or cytogenetic/molecular data or a combination thereof.
  • When karyotypic information from this series was combined with available literature data, it was found that the sensitivity of 8q11-13 rearrangements for diagnosing lipoblastomas when found in a lipomatous tumour was 77% and that the corresponding specificity was 98%.
  • The validity of these calculations of the diagnostic information provided by the cytogenetic findings is, of course, totally dependent on the morphological diagnosis made in each case.
  • Regardless of what the precise phenotypic diagnosis was, it is suggested that lipomatous tumours with 8q11-13 rearrangement constitute a distinct pathogenetic entity.
  • When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8. Gene Rearrangement. Lipoma / genetics. Neoplasms, Adipose Tissue / genetics

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  • (PMID = 16308870.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / PLAG1 protein, human
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43. Prevoo W, van den Bosch MA, Horenblas S: Radiofrequency ablation for treatment of sporadic angiomyolipoma. Urology; 2008 Jul;72(1):188-91
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  • We used another technique, that is, radiofrequency ablation (RFA), for treatment of a sporadic AML in a patient with a solitary kidney, in whom maximal sparing of normal renal tissue was required.
  • TECHNICAL CONSIDERATIONS: Contrast-enhanced computed tomography (CT) showed an enhancing well-defined mainly lipomatous tumor, with a maximum diameter of 4.5 cm in the upper pole of the left kidney.
  • Diagnosis of AML was confirmed with fine-needle aspiration biopsy.
  • RFA was performed with a RF 3000 system, consisting of a generator that supplied up to 200W of power, connected to a 15-gauge LeVeen multipolar array electrode that was placed under CT-guidance centrally in the AML.
  • Initial power was set at low power and increased with increments of 10W, according to the algorithm provided by the manufacturer, resulting in a final tumor end temperature above 65 degrees C.
  • During follow-up (12 months) function of the solitary kidney of the patient was preserved and patient did not have any AML-related symptoms develop.
  • Contrast-enhanced CT scan showed complete (100%) tumor ablation with absence of enhancement in the tumor and decreased tumor size from 4.5 cm to 2.9 cm at 12 months.
  • CONCLUSIONS: CT-guided RFA is a minimally invasive ablation procedure that allowed successful treatment of a sporadic AML in a patient with a solitary kidney.
  • [MeSH-major] Angiomyolipoma / surgery. Catheter Ablation. Kidney Neoplasms / surgery

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  • (PMID = 18455777.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Weaver J, Goldblum JR, Turner S, Tubbs RR, Wang WL, Lazar AJ, Rubin BP: Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma. Mod Pathol; 2009 Jan;22(1):66-70
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  • Inflammatory liposarcoma is a variant of well-differentiated liposarcoma/atypical lipomatous tumor that consists of a mixture of lymphocytes, histiocytes, scattered atypical stromal cells, mature adipocytes, and rarely lipoblasts.
  • When the inflammatory infiltrate predominates, the morphological features overlap with various fibroinflammatory disorders including sclerosing mesenteritis and retroperitoneal fibrosis, making the diagnosis difficult.
  • Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma have characteristic molecular markers in the form of giant marker and ring chromosomes consisting of amplicons of 12q13-15, which includes MDM2.
  • [MeSH-major] Biomarkers, Tumor / genetics. Liposarcoma / diagnosis. Panniculitis, Peritoneal / diagnosis. Proto-Oncogene Proteins c-mdm2 / genetics. Retroperitoneal Fibrosis / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Gene Amplification. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Inflammation / diagnosis. Inflammation / genetics. Sensitivity and Specificity


45. Akhaddar A, Albouzidi A, Elmostarchid B, Gazzaz M, Boucetta M: Sudden onset of paraplegia caused by hemorrhagic spinal epidural angiolipoma. A case report. Eur Spine J; 2008 Sep;17 Suppl 2:S296-8
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  • Spinal epidural angiolipoma is a rare benign tumor containing vascular and mature adipose elements.
  • A bilateral T2-T4 laminectomy was performed to achieve resection of a lipomatous tumor containing area of spontaneous hemorrhage.
  • Histologic examination revealed the tumor as an angiolipoma.
  • Because the prognosis after rapid surgical management of this lesion is favorable, the diagnosis of spinal angiolipoma with bleeding should be considered in the differential diagnosis of hyperacute spinal cord compression.
  • [MeSH-major] Angiolipoma / complications. Hematoma, Epidural, Spinal / etiology. Hemorrhage / complications. Paraplegia / etiology. Spinal Cord Compression / etiology. Spinal Neoplasms / complications
  • [MeSH-minor] Back Pain / etiology. Decompression, Surgical. Diagnosis, Differential. Disease Progression. Epidural Space / pathology. Epidural Space / physiopathology. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Cord / pathology. Spinal Cord / physiopathology. Spine / pathology. Spine / physiopathology. Thoracic Vertebrae / pathology. Thoracic Vertebrae / physiopathology. Treatment Outcome

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  • [Cites] Neurochirurgie. 2000 Dec;46(6):523-533 [11148405.001]
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  • (PMID = 18228054.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2525899
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46. Mentzel T, Palmedo G, Kuhnen C: Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. Mod Pathol; 2010 May;23(5):729-36
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  • [Title] Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases.
  • Well-differentiated spindle cell liposarcoma represents a rare atypical/low-grade malignant lipogenic neoplasm that has been regarded as a variant of atypical lipomatous tumor.
  • However, well-differentiated spindle cell liposarcoma tends to occur in subcutaneous tissue of the extremities, the trunk, and the head and neck region, contains slightly atypical spindled tumor cells often staining positively for CD34, and lacks an amplification of MDM2 and/or CDK4 in most of the cases analyzed.
  • The neoplasms arose on the shoulder, the chest wall, the thigh, the lower leg, the back of the hand, and in paratesticular location.
  • The size of the neoplasms ranged from 1.5 to 10 cm (mean: 6.0 cm).
  • All neoplasms were completely excised.
  • The neoplasms were confined to the subcutis in three cases, and in three cases, an infiltration of skeletal muscle was seen.
  • Histologically, the variably cellular neoplasms were composed of atypical lipogenic cells showing variations in size and shape, and spindled tumor cells with slightly enlarged, often hyperchromatic nuclei.
  • Multivacuolated lipoblasts were present in three neoplasms.
  • Immunohistochemically, CD34 was at least focally positive in all cases, whereas scattered tumor cells only showed a nuclear expression of MDM2 in two neoplasms.
  • Although well-differentiated spindle cell liposarcoma and atypical lipomatous tumor behave clinically similar, it can be speculated on the basis of clinicopathologic and molecular findings that well-differentiated spindle cell liposarcoma may constitute an independent entity rather than a morphologic variant of atypical lipomatous tumor, and may represent the atypical/low-grade counterpart of spindle cell lipoma.
  • [MeSH-major] Hand / pathology. Leg / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20228779.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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47. Scariot R, Giovanini AF, Torres-Pereira CC, Piazzetta CM, Costa DJ, Rebellato NL, Müller PR: Massive growth of an intraoral lipoma. J Contemp Dent Pract; 2008;9(7):115-21
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  • BACKGROUND: Lipoma, a benign tumor of adipose tissue, is rarely seen in the oral cavity.
  • A clinical diagnosis of lipoma was established, and the treatment consisted of complete excision of the mass under local anesthesia.
  • [MeSH-major] Cheek / pathology. Lipoma / pathology. Mouth Neoplasms / pathology

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  • (PMID = 18997924.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Hameed M: Pathology and genetics of adipocytic tumors. Cytogenet Genome Res; 2007;118(2-4):138-47
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  • [Title] Pathology and genetics of adipocytic tumors.
  • Adipocytic tumors are common mesenchymal neoplasms with considerable morphologic and genetic heterogeneity.
  • The fruitful integration of morphology and cytogenetics in the past 15 years has not only enhanced the diagnostic accuracy, but also refined the various pathological classifications and subtypes in these tumors.
  • The current WHO classification includes eleven benign subtypes, one intermediate and five categories of malignant fatty neoplasms with incorporation of relevant genetic findings.
  • Of the benign tumors, lipomas have been extensively analyzed by chromosome banding which has shown that their cytogenetic patterns are heterogeneous.
  • Among the malignant tumors, the t(12;16)(q13;p11) resulting in the fusion of DDIT3 and FUS genes is the hallmark of myxoid and round cell liposarcoma and is used as a highly specific and sensitive marker of this entity.
  • The tumor in the intermediate group, atypical lipomatous neoplasm/well-differentiated liposarcoma which poses morphologic challenges due to close histological similarity to benign lipomas shows characteristic supernumerary rings and giant rod chromosomes due to amplification of the 12q14-->q15 region often involving the MDM2 oncogene.
  • This review will focus on the pathological features of the various adipocytic tumors and relevant genetic findings reported in the literature.
  • [MeSH-major] Adipocytes. Neoplasms / genetics. Neoplasms / pathology

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 18000364.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 76
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49. Funahashi Y, Kamihira O, Isobe Y, Kimura K, Sasa N, Matsuura O: [Retroperitoneal liposarcoma: a case report]. Hinyokika Kiyo; 2006 Mar;52(3):203-5
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  • A 66-year-old male was referred to our hospital for a retroperitoneal tumor that was detected during gallbladder stone examination.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) revealed an extrarenal lipomatous tumor, 20 x 14 x 8 cm in size, in the right retroperitoneal space.
  • He underwent surgical excision of the tumor with concomitant resection of the right kidney and adrenal gland.
  • The resected tissue weighed 730 g.
  • [MeSH-major] Liposarcoma / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16617874.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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50. Vecchio G, Amico P, Caltabiano R, Colella G, Lanzafame S, Magro G: Spindle cell/pleomorphic lipoma of the oral cavity. J Craniofac Surg; 2009 Nov;20(6):1992-4
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  • We herein report a rare case of a lipomatous tumor of the buccal mucosa, showing intermediate morphological features between spindle cell and pleomorphic lipomas, for which the term spindle cell/pleomorphic lipoma is proposed.
  • Morphological features helpful in the distinction between these tumors are emphasized.
  • [MeSH-major] Lipoma / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Liposarcoma / pathology. Male. Middle Aged. Mouth Mucosa / pathology. Receptors, Androgen / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis

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  • (PMID = 19881383.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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51. de Vreeze RS, Koops W, Haas RL, van Coevorden F: An unusual case of hemosiderotic fibrohistiocytic lipomatous lesion: correlation of MRI and pathologic findings. Sarcoma; 2008;2008:893918
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  • [Title] An unusual case of hemosiderotic fibrohistiocytic lipomatous lesion: correlation of MRI and pathologic findings.
  • The spectrum of lipomatous lesions ranges from benign to highly malignant disease.
  • Differentiation between these lesions is important to indicate prognosis and choose the most appropriate treatment.
  • Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) is a rare subtype of lipomatous tumor.
  • The diagnosis is usually based on clinical, histological, and immunohistochemical information.
  • Where magnetic resonance (MR) imaging is a suitable modality to assess fatty tumors, no data is reported on MR imaging of HFLL.

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  • (PMID = 18584051.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2435605
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52. Kubo T, Matsui Y, Naka N, Araki N, Myoui A, Endo K, Yasui N, Ohtani O, Suzuki K, Kimura T, Yoshikawa H, Ueda T: Specificity of fusion genes in adipocytic tumors. Anticancer Res; 2010 Feb;30(2):661-4
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  • [Title] Specificity of fusion genes in adipocytic tumors.
  • BACKGROUND: In subsets of adipocytic tumors, specific chromosomal translocations lead to the generation of fusion genes.
  • However, the specificity of these fusion genes has not been established in a variety of adipocytic tumors.
  • PATIENTS AND METHODS: One hundred and seventy-two cases of adipocytic tumors, comprising 98 cases of lipoma and 74 cases of liposarcoma, were analyzed for the possible expression of HMGA2-LPP, LPP-HMGA2, TLS-CHOP and EWS-CHOP fusion genes, using a reverse-transcription polymerase chain reaction method.
  • [MeSH-minor] Cell Differentiation. Humans. Neoplasm Staging. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Retrospective Studies. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20332486.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DDIT3 protein, human; 0 / HMGA Proteins; 0 / HMGA2-LPP fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / RNA-Binding Protein EWS; 0 / RNA-Binding Protein FUS; 0 / TLS-CHOP fusion protein, human; 147336-12-7 / Transcription Factor CHOP
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53. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • Multinucleated floret cells present in prolapsed orbital fat likely represent a reactive phenomenon, as they are not present in normal orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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54. Kurita H, Kamata T, Koike T, Kobayashi H, Kurashina K: Intraoperative tissue staining of invaded oral carcinoma. Pathol Oncol Res; 2008 Dec;14(4):461-5
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  • [Title] Intraoperative tissue staining of invaded oral carcinoma.
  • The purpose of this study was to assess the ability of intraoperative tissue staining with consecutive application of 0.4% indigo carmine and 0.5% Congo red to demonstrate the extent and border of oral carcinoma invasion.
  • Once the oral tumor was resected, a vertical section of surgical specimen was taken from the central part of the tumor.
  • The extent and border of the invaded carcinoma were assessed on digital microscopic examination with tissue staining.
  • Tissue staining produced a brown-black stain on normal muscle, connective, and salivary tissues but not tumor and epithelial tissues.
  • It clearly demonstrated the extent and border of tumor invasion in 13 of 17 patients (76.5%); however, detection of remnant vital tumor cells in scar tissue after neoadjuvant chemotherapy, and distinction between the tumor and adipose tissue scattered in the muscle tissue was difficult.
  • The results of this study showed that intraoperative tissue staining was a possible method in demonstrating the extent and border of carcinoma deeply invaded in the soft tissue and selecting the site for additional frozen section analysis, although the method needed some refinement.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neoplasm Staging / methods. Staining and Labeling / methods

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  • [Cites] Trans Am Acad Ophthalmol Otolaryngol. 1974 Jan-Feb;78(1):ORL49-53 [4813646.001]
  • [Cites] Cancer. 1982 Dec 15;50(12):2956-60 [7139587.001]
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  • (PMID = 18575826.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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55. Tosios KI, Koutlas IG, Kyriakopoulos VF, Balta M, Theologie-Lygidakis N, Vardas E, Iatrou I: Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Oct;110(4):492-7
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  • [Title] Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes.
  • Angiomyolipoma (AML) is the most common benign mesenchymal neoplasm of the kidneys with well-established clinical and morphological features.
  • The oral and maxillofacial pathology literature contains several examples that identify angiomyomatous proliferations of the oral mucosa that contain an adipocytic component as analogous to classic renal AMLs although they differ significantly in their immunohistochemical phenotype.
  • Herein, through review of the pertinent oral pathology literature and the detailed description of 2 lesions, one an oral angiomyoma with an adipocytic component and the other an apparently hamartomatous angioleiomyomatous proliferation with adipocytes, we provide, in our opinion, a solid argument against the use of the term AML for non-PEComatous oral tumors.
  • [MeSH-major] Angiomyolipoma / classification. Mouth Neoplasms / classification. Terminology as Topic

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20674420.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins; 0 / von Willebrand Factor
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56. Aleixo PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM: Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol; 2009 Dec;62(12):1127-35
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  • [Title] Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours.
  • METHODS: IHC for MDM2/CDK4 was carried out on a series of 129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours.
  • The cases were divided into four groups: WDLPS (n = 19), DDLPS (n = 10), benign adipocytic tumours (BAT) (n = 17), and other mesenquimal tumours (OMT) (n = 83).
  • IHC results were compared in each group and the diagnostic efficacy of the test in identifying WDLPS and DDLPS among the other soft tissue tumours was determined.
  • A percentage of tumour cell positivity was evaluated to better characterise the pattern of tumour immunostaining.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase 4 / metabolism. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Sensitivity and Specificity

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  • (PMID = 19946100.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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57. Ruiz E, Pozo P, Toselli L, Fernández M, Christiansen S, Lambertini R: Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma. Urology; 2008 Jun;71(6):1067-9
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  • [Title] Unusual benign paratesticular tumor in an infant mimicking rhabdomyosarcoma.
  • Paratesticular tumors are extremely rare, with paratesticular rhabdomyosarcoma being the most common finding.
  • A 6-month-old boy presented with an asymptomatic, right intrascrotal mass whereby the testicle was surrounded by a friable lipomatous tumor.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Testicular Diseases / pathology. Testicular Neoplasms / pathology. Xanthogranuloma, Juvenile / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Infant. Male

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  • (PMID = 18538690.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Rajeswaran R, Murthy J, Chandrasekharan A, Joseph S: Case Report: Congenital infiltrating lipomatosis of face. Indian J Radiol Imaging; 2008 Nov;18(4):306-9
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  • Congenital infiltrating lipomatosis of the face is a rare condition characterized by diffuse fatty infiltration of the facial soft tissues.
  • It is a type of lipomatous tumor that is congenital in origin; it is rare and seen usually in childhood.

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  • [Cites] Pediatr Radiol. 2006 Nov;36(11):1159-62 [16953375.001]
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  • (PMID = 19774187.001).
  • [ISSN] 0971-3026
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2747453
  • [Keywords] NOTNLM ; Congenital / lipomatosis
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59. Novikov VV, Novikov GV, Fesenko EE: Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics; 2009 Jul;30(5):343-51
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  • [Title] Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma.
  • It was shown that the exposure of mice with EAC to combined MFs causes structural changes in some organs (liver, adrenal glands), which are probably due to the total degradation of the tumor tissue.
  • In mice with transplanted EAC, the tumor tissue after exposure to weak MFs was practically absent, as distinct from control animals in which the invasion of the tumor into the adipose tissue surrounding the kidneys, mesenteric lymph nodes, and spermatic appendages was observed.
  • In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism.
  • [MeSH-major] Carcinoma, Ehrlich Tumor / pathology. Carcinoma, Ehrlich Tumor / therapy. Magnetic Field Therapy / methods. Magnetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19267367.001).
  • [ISSN] 1521-186X
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Kabasawa Y, Katsube K, Harada H, Nagumo K, Terasaki H, Perbal B, Okada N, Omura K: A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):677-82
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  • [Title] A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor.
  • METHODS: We examined morphological aspects of the tumor and immunohistochemical patterns.
  • RESULTS: Tumor proliferation was infiltrative, which did not show apparent encapsulation.
  • Positive immunoreactivity was found for CD-34, CD-99, Ki-67, and connective tissue growth factor/CCN2 in the fibrous region, S-100 in the adipose region, and Notch1 stain was observed in the eccrine sweat gland cells juxtaposed to the tumor adipose tissue, but no reactivity for Bcl-2, alphaSMA, Notch 2-4, CCN1, and CCN3.
  • Specific expression of CCN2 might be significant for the development of the tumor.
  • [MeSH-major] Fibroma / pathology. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Lipoma / pathology
  • [MeSH-minor] Adipose Tissue / chemistry. Adipose Tissue / pathology. Antigens, CD / analysis. Antigens, CD34 / analysis. Cell Adhesion Molecules / analysis. Connective Tissue Growth Factor. Humans. Immediate-Early Proteins / biosynthesis. Immunohistochemistry. Infant. Insulin-Like Growth Factor Binding Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Ki-67 Antigen / analysis. Male. Neoplasm Proteins / biosynthesis. Nephroblastoma Overexpressed Protein. Receptor, Notch1 / biosynthesis. S100 Proteins / analysis

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  • (PMID = 17466886.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / CTGF protein, human; 0 / Cell Adhesion Molecules; 0 / Immediate-Early Proteins; 0 / Insulin-Like Growth Factor Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / NOTCH1 protein, human; 0 / NOV protein, human; 0 / Neoplasm Proteins; 0 / Nephroblastoma Overexpressed Protein; 0 / Receptor, Notch1; 0 / S100 Proteins; 139568-91-5 / Connective Tissue Growth Factor
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61. Femia A, Klein PA: Letter: Iatrogenic lipomatosis: a rare manifestation of treatment with a peroxisome proliferator-activated receptor gamma agonist. Dermatol Online J; 2010;16(4):15
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  • Lipomas are common benign neoplasms of adipose tissue.
  • [MeSH-major] Diabetes Mellitus, Type 2 / drug therapy. Hypoglycemic Agents / adverse effects. Lipoma / chemically induced. Neoplasms, Multiple Primary / chemically induced. PPAR gamma / agonists. Skin Neoplasms / chemically induced. Thiazolidinediones / adverse effects
  • [MeSH-minor] Adipose Tissue / drug effects. Aged. Female. Humans. Iatrogenic Disease

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  • (PMID = 20409422.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypoglycemic Agents; 0 / PPAR gamma; 0 / Thiazolidinediones; X4OV71U42S / pioglitazone
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62. Ferrari G, Paci M, Sgarbi G: Thymolipoma of the anterior mediastinum: videothoracoscopic removal using a bilateral approach. Thorac Cardiovasc Surg; 2006 Sep;54(6):435-7
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  • Thymolipoma, a rare benign neoplasm of the anterior mediastinum, is often asymptomatic and as a result it can become quite large before it is diagnosed.
  • CT is the most accurate diagnostic technique to identify the adipose tissue, but it often cannot make a differential diagnosis differentiating it from other anterior mediastinal masses; transthoracic biopsy also reveals the presence of fatty tissue, but a definitive diagnosis can only be achieved by means of surgical excision, which is also curative.
  • We describe the case of a young woman who presented with a fatty neoplasm of the anterior mediastinum.
  • The histopathological diagnosis was thymolipoma.
  • [MeSH-major] Lipoma / surgery. Mediastinal Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thymus Neoplasms / surgery

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  • (PMID = 16967386.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Kuhnen C, Mentzel T, Lehnhardt M, Homann HH, Sciot R, Debiec-Rychter M: [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition]. Pathologe; 2010 Mar;31(2):129-34
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  • [Title] [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition].
  • [Transliterated title] Lipom und atypischer lipomatöser Tumor innerhalb einer Neoplasie: Hinweis für einen kontinuierlichen Ubergang.
  • The case of a lipomatous tumor with a predominant lipoma component and transition to an atypical lipomatous tumor is presented.
  • A deep-seated soft tissue tumor of the right thigh with a maximum size of 14 cm was resected in a 70-year-old female patient.
  • In the remaining portion (approximately 20%) histopathology showed an atypical lipomatous tumor (ALT, lipoma-like subtype).
  • Interphase dual-color fluorescence in situ hybridization showed no amplification of the MDM 2 gene and rarely CDK4 gene amplification within the lipoma component, but high level amplification of MDM 2/CDK4 gene in the ALT area, further supporting the morphologically based diagnosis of a lipomatous tumor including areas of a true lipoma and ALT.
  • This case underlines the concept of a continuous stepwise development of lipomatous soft tissue tumors from benign to malignant counterparts as a biological continuum.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. In Situ Hybridization, Fluorescence. Proto-Oncogene Proteins c-mdm2 / genetics. Thigh

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  • (PMID = 20063101.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.3.2.27 / MDM2 protein, human; EC 2.3.2.27 / Proto-Oncogene Proteins c-mdm2; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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64. Suster S, Morrison C: Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Histopathology; 2008 Feb;52(3):283-93
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  • [Title] Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue.
  • AIMS: To present eight cases of a distinctive morphological subtype of lipomatous tumour of soft tissue.
  • Four cases arose de novo and four cases presented as local recurrences of previously resected liposarcomas.
  • [MeSH-major] Liposarcoma / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. RNA-Binding Protein FUS / genetics. Soft Tissue Neoplasms / pathology. Transcription Factor CHOP / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Fatal Outcome. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Recurrence, Local. Sclerosis / pathology. Translocation, Genetic

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  • (PMID = 18269578.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Protein FUS; 0 / TLS-CHOP fusion protein, human; 147336-12-7 / Transcription Factor CHOP; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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65. Kaneko G, Nishimoto K, Ogata K, Uchida A: [A case of lipomatous tumor arising from the paratesticular lesion]. Hinyokika Kiyo; 2009 Nov;55(11):725-7
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  • [Title] [A case of lipomatous tumor arising from the paratesticular lesion].
  • We encountered a case of lipomatous tumor in the left scrotum, which was clinically and radiologically quite similar to an inguinal hernia.
  • A 75-year-old male patient visited a nearby hospital complaining of a painless left scrotal swelling.
  • The tumor marker levels were within the normal range.
  • A preoperative diagnosis of inguinal hernia containing the omentum was made.
  • Microscopically, most of the tumor consisted of mature adipocytes, some of which had different cellular sizes.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Lipoma / pathology. Scrotum

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  • (PMID = 19946194.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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66. Arikawa S, Uchida M, Shinagawa M, Tohnan T, Hayabuchi N: Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst. Kurume Med J; 2006;53(1-2):37-40
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  • [Title] Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst.
  • Although a series of imaging studies suggested a lipomatous tumor, diagnosis was difficult because the tumor appeared as a pedunculated mass extending from the uterine body.
  • To distinguish the tumor from an ovarian lipomatous tumor, the "beak sign" in a magnetic resonance imaging study was diagnostic in this case.
  • The purpose of this paper is to review lipomatous masses of the female pelvis, to discuss the differential diagnosis of the unusual imaging features, and to discuss imaging techniques to optimize pelvic mass characterization.
  • [MeSH-major] Leiomyoma / diagnosis. Lipoma / diagnosis. Ovarian Cysts / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17043394.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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67. Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, Van Belle PA, Xu X, Elder DE, Herlyn M: A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res; 2005 Oct 15;65(20):9328-37
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  • Recent studies suggest that cancer can arise from a cancer stem cell (CSC), a tumor-initiating cell that has properties similar to those of stem cells.
  • Individual cells from melanoma spheres (melanoma spheroid cells) could differentiate under appropriate conditions into multiple cell lineages, such as melanocytic, adipocytic, osteocytic, and chondrocytic lineages, which recapitulates the plasticity of neural crest stem cells.
  • [MeSH-minor] Animals. Antigens, CD20 / biosynthesis. Cell Adhesion. Cell Differentiation. Cell Line, Tumor. Fibroblasts / cytology. Flow Cytometry. Humans. Mice. Mice, SCID. Neoplasm Transplantation. Spheroids, Cellular. Transplantation, Heterologous

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  • (PMID = 16230395.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA10815; United States / NCI NIH HHS / CA / CA25874; United States / NCI NIH HHS / CA / CA76674; United States / NCI NIH HHS / CA / CA80999
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD20
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68. Adachi S, Kawamura N, Hatano K, Kakuta Y, Takada T, Hara T, Yamaguchi S: Lipomatous ganglioneuroma of the retroperitoneum. Pathol Int; 2008 Mar;58(3):183-6
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  • [Title] Lipomatous ganglioneuroma of the retroperitoneum.
  • A unique case of ganglioneuroma mimicking a lipomatous tumor in a 73-year-old man is reported.
  • The tumor was incidentally found on radiography performed for unrelated reasons.
  • The laparotomy indicated that the tumor was located on the right adrenal gland.
  • It was well circumscribed but not encapsulated, and was approximately 2 cm in diameter.
  • Microscopically, ganglioneuromatous component was scattered in the background of a large amount of adipose tissue.
  • Because the presence of such a large amount of adipose tissue seems to be rare in ganglioneuromas, its histogenesis is discussed.
  • [MeSH-major] Adipose Tissue / pathology. Ganglioneuroma / diagnosis. Myelolipoma / diagnosis. Retroperitoneal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Chromogranins / analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Male. S100 Proteins / analysis. Synaptophysin / analysis

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  • (PMID = 18251782.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranins; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Synaptophysin
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69. Coffin CM, Lowichik A, Putnam A: Lipoblastoma (LPB): a clinicopathologic and immunohistochemical analysis of 59 cases. Am J Surg Pathol; 2009 Nov;33(11):1705-12
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  • Lipoblastoma (LPB) is a benign neoplasm that occurs predominantly in early childhood.
  • Immunohistochemistry for S100 protein, CD34, and Mib-1 was performed on formalin-fixed, paraffin-embedded tissue using standard techniques.
  • Age at diagnosis ranged from 3 months to 16 years with 22% in the first year, 68% at 1 to 9 years, and 10% at 10 to 16 years.
  • Tumor diameter ranged from 1.2 to 15.5 cm.
  • Histologically, nodules of adipose and myxoid tissue were demarcated by bands of fibrous tissue.
  • The cells displayed a range of differentiation from multivacuolated lipoblasts to mature adipocytes.
  • In summary, this large series of LPB demonstrates its occurrence in older children and adolescents, documents a recurrence rate of 46% and confirms that the degree of adipocytic differentiation does not predict biologic behavior.
  • An unexpected finding was the presence in 17% of patients of central nervous system disorders such as seizures, autism, and developmental delay, congenital anomalies, Sturge-Weber syndrome, or a family history of lipomas.
  • These observations raise the question of whether predisposing genetic or other constitutional factors contribute to the development of LPB or whether LPB is indicative of a syndrome.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / chemistry. Adipocytes / pathology. Adolescent. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Child. Child, Preschool. Chromosome Aberrations. Chromosomes, Human, Pair 8. Female. Humans. Immunohistochemistry. Infant. Male. Neoplasm Recurrence, Local. S100 Proteins / analysis


70. Gómez FJ, Machin PF, Galán JM: [Atypical lipomatous paratesticular tumour]. Arch Esp Urol; 2009 May;62(4):325-6
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  • [Title] [Atypical lipomatous paratesticular tumour].
  • [Transliterated title] Tumor lipomatoso atípico paratesticular.
  • [MeSH-major] Lipoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 19736687.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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71. Weaver J, Rao P, Goldblum JR, Joyce MJ, Turner SL, Lazar AJ, López-Terada D, Tubbs RR, Rubin BP: Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol; 2010 Oct;23(10):1301-6
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  • Well-differentiated liposarcoma/atypical lipomatous tumor can be difficult to differentiate from benign lipomatous tumors, especially on limited biopsy material.
  • Adjunctive tests for MDM2 (murine double minute 2) have proven useful in whole-tissue sections; however, their utility has not been determined within the increasingly popular core needle biopsy.
  • Herein, we compare the ability of MDM2 immunohistochemistry and MDM2 fluorescence in situ hybridization (FISH) to discriminate benign lipomatous tumors from well-differentiated liposarcoma on core needle biopsies.
  • Well-differentiated liposarcoma (n=17) and an assortment of benign lipomatous tumors (n=37), which had concurrent or previous core needle biopsies, and resection specimens were subjected to both MDM2 immunohistochemistry and MDM2 FISH on both whole-tissue sections and corresponding core needle biopsy sections.
  • Percentage tumor cells positive for MDM2 by immunohistochemistry and an MDM2:CEP12 FISH ratio was calculated in each biopsy and resection specimen pair and the results were compared.
  • The average MDM2:CEP12 ratio was similar in the biopsy material compared with the whole-tissue sections in both well-differentiated liposarcoma and the benign lipomatous tumor group of neoplasms.
  • Detection of MDM2 amplification by FISH is a more sensitive and specific adjunctive test than MDM2 immunohistochemistry to differentiate well-differentiated liposarcoma from various benign lipomatous tumors, especially on limited tissue samples.
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy, Needle. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / biosynthesis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Lipoma / diagnosis. Sensitivity and Specificity


72. Li H, Fan X, Kovi RC, Jo Y, Moquin B, Konz R, Stoicov C, Kurt-Jones E, Grossman SR, Lyle S, Rogers AB, Montrose M, Houghton J: Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res; 2007 Nov 15;67(22):10889-98
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  • Based on the facts that mesenchymal stem cells (MSC) transform with higher frequency than other cell types, and tumors in aged C57BL/6 mice are frequently fibrosarcomas, we used a genetically tagged bone marrow (BM) transplant model to show that aged mice develop MSC-derived fibrosarcomas.
  • Spontaneously transformed MSCs contribute directly to the tumor, tumor vasculature, and tumor adipose tissue, recruit additional host BM-derived cells (BMDC) to the area, and fuse with the host BMDC.
  • Unfused transformed MSCs act as the cancer stem cell and are able to form tumors in successive mice, whereas fusion restores a nonmalignant phenotype.
  • These data suggest that MSCs may play a key role in age-related tumors, and fusion with host cells restores a nonmalignant phenotype, thereby providing a mechanism for regulating tumor cell activity.


73. Mineo JF, P-Ruchoux MM, Pasquier D, Rigolle H, Assaker R: [Primitive malignant melanoma arising in a spinal nerve root. A case report]. Neurochirurgie; 2006 Jun;52(2-3 Pt 1):133-7
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  • The T1-weighted MRI images showed a tumor hyperintensity, the T2-weighted images showed tumor isointensity and mild contrast enhancement.
  • Due to the scalloping of L3/L4 foramen with root enlargement and slow evolution (more than one year between the first symptom and surgery without clinical worsening), the initial preoperative diagnosis was L3 schwannoma.
  • The tumor was composed of irregular melanocytoid cells with high proliferation index (20%).
  • So, the final diagnosis was intradural primitive malignant melanoma.
  • Radiotherapy was performed on the site of the tumor.
  • The most common tumor with root enlargement and bony scalloping is the benign schwannoma.
  • Despite the above described radiological features, MRI characteristics (hyperintensity when images are T1-weighted) suggest a melanocytic tumor, a tumor with a high adipose component or an intratumoral bleeding.
  • Specific MRI sequences can eliminate adipose tissue tumor, but diagnosis between melanin and methemoglobin is still difficult.
  • These tumors show identical protein expressions in immunohistochemistry, and their prognosis is very variable (some long-term remissions are reported for malignant melanomas and fast disseminations are described for meningeal melanocytomas treated by sub-total surgery).
  • [MeSH-major] Melanoma / pathology. Spinal Neoplasms / pathology. Spinal Nerve Roots / pathology
  • [MeSH-minor] Adult. Antigens, Neoplasm. Cell Proliferation. Fatal Outcome. Female. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Melanins / metabolism. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. Neurologic Examination. S100 Proteins / metabolism

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  • (PMID = 16840974.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanins; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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74. Kuriu A, Shimono T, Kuwabara M, Ashikaga R, Hosono M, Murakami T: Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult. Jpn J Radiol; 2010 Feb;28(2):166-8
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  • [Title] Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult.
  • We report a case of fourth ventricular mixed germ cell tumor (GCT) in a 20-year-old man.
  • Neuroradiological investigations revealed a fourth ventricular hemorrhagic tumor with adipose tissue.
  • We suspected mixed GCT because adipose tissue was seen preoperatively, but mixed GCT occurring after childhood in this location has not previously been reported.
  • We describe herein the imaging findings for mixed GCT and discuss the differential diagnoses of fourth ventricular tumors with adipose tissue.
  • [MeSH-major] Adipose Tissue / diagnostic imaging. Adipose Tissue / pathology. Brain Neoplasms / diagnosis. Fourth Ventricle / diagnostic imaging. Fourth Ventricle / pathology. Neoplasms, Germ Cell and Embryonal / diagnosis
  • [MeSH-minor] Adult. Biomarkers / blood. Biomarkers, Tumor / blood. Cerebral Ventriculography / methods. Chorionic Gonadotropin / blood. Contrast Media. Diagnosis, Differential. Follow-Up Studies. Headache / etiology. Humans. Hydrocephalus / complications. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods. Vomiting / etiology. Young Adult. alpha-Fetoproteins

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  • (PMID = 20182853.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin; 0 / Contrast Media; 0 / alpha-Fetoproteins
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75. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Colella G, Biondi P, Caltabiano R, Vecchio GM, Amico P, Magro G: Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J; 2009;2:7906
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  • A 75-year-old Italian male presented at our department with a large tumor at the tip of the tongue that had been present for over 30 years.
  • Histological examination showed an unencapsulated lipomatous tumor composed of mature adipocytes, uniform in size and shape, diffusely infiltrating striated muscle fibers of the tongue.

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  • (PMID = 19830025.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3302006
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77. He M, Aisner S, Benevenia J, Patterson F, Aviv H, Hameed M: p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):51-6
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  • [Title] p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.
  • Atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive malignant mesenchymal neoplasm, resembling ordinary lipoma in many clinical aspects.
  • Fifty cases of lipomatous neoplasms, with cytogenetic results, from 45 patients were collected from the archives in Department of Pathology, University of Medicine and Dentistry of New Jersey/New Jersey Medical School during 1998 to 2006.

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  • (PMID = 18779733.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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78. Matushansky I, Hernando E, Socci ND, Matos T, Mills J, Edgar MA, Schwartz GK, Singer S, Cordon-Cardo C, Maki RG: A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas. Am J Pathol; 2008 Apr;172(4):1069-80
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  • [Title] A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.
  • We hypothesized that sarcomas of soft tissue could be categorized by their developmental/differentiation status from stem cell to mature tissue, similar to the hematological malignancies.
  • We conducted gene expression analyses during in vitro differentiation of human mesenchymal stem cells into adipose tissue, as a representative mature connective tissue, and identified genes whose expression changed significantly during adipogenesis.
  • Gene clustering and distance correlation analysis allowed the assignment of a unique time point during adipogenesis that strongly correlates to each of the four major liposarcoma subtypes.
  • Using a novel gene expression strategy, in which liposarcomas are compared to their corresponding adipocytic maturing cells, we identified a group of genes overexpressed in liposarcomas that indicate the stage of differentiation arrest, ie, sharing a similar expression profile to adipocytic cells at a corresponding stage of differentiation, and a distinct set of genes overexpressed in liposarcomas that are not found in the corresponding stage of differentiation.
  • Our results indicate that a degree of developmental maturity can be quantitatively assigned to solid tumors, supporting the notion that transformation of a solid tumor stem cell can occur at distinct stages of maturation.

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  • (PMID = 18310505.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179; United States / NCI NIH HHS / CA / CA 47179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC2276417
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79. Tanas MR, Rubin BP, Tubbs RR, Billings SD, Downs-Kelly E, Goldblum JR: Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience. Arch Pathol Lab Med; 2010 Dec;134(12):1797-803
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  • [Title] Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience.
  • CONTEXT: Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH).
  • OBJECTIVE: To determine the utility of FISH in the diagnosis of mesenchymal neoplasms.
  • DESIGN: Two hundred thirty soft tissue cases analyzed by FISH were reviewed retrospectively.
  • RESULTS: Morphologic patterns where FISH was used included high-grade round cell sarcomas (n  =  67), nonmyogenic spindle cell sarcomas (n  =  40), low-grade myxoid neoplasms (n  =  34), adipocytic neoplasms (n  =  20), and melanocytic neoplasms (n  =  19).
  • Fifty cases did not fit into the previously mentioned categories.
  • SYT FISH (96% of monophasic synovial sarcomas were positive; 0% of malignant peripheral nerve sheath tumor were positive) and DDIT3 FISH (100% of myxoid/round cell liposarcomas; no other neoplasm positive) were very sensitive and specific.
  • EWSR1 FISH was very sensitive and specific in the differential diagnosis of melanocytic neoplasms (88% of clear cell sarcomas were positive; all melanomas were negative).
  • EWSR1 FISH was sensitive among high-grade round cell sarcomas (positive in 100% of desmoplastic small round cell tumors and 96% of Ewing sarcoma/primitive neuroectodermal tumors) but not specific because clear cell sarcoma, extraskeletal myxoid chondrosarcoma, and a subset of round cell liposarcomas also harbor rearrangements of EWSR1.
  • FUS FISH was very sensitive in detecting low-grade fibromyxoid sarcomas (91% positive) but not specific because most myxoid/round cell liposarcomas also contain rearrangements of FUS.
  • All atypical lipomatous tumors were positive for amplification of MDM2, whereas all lipomas were negative.
  • CONCLUSION: FISH is a useful adjunct in the diagnosis of mesenchymal neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Melanoma / diagnosis. Neoplasms, Adipose Tissue / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Chromosome Aberrations. Humans. Molecular Diagnostic Techniques


80. Yamaguchi T, Takimoto T, Yamashita T, Kitahara S, Omura M, Ueda Y: Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney. Urology; 2005 Jan;65(1):175
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  • [Title] Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney.
  • Fat-containing variant of a solitary fibrous tumor is a recently recognized benign soft-tissue tumor that usually affects the thigh and retroperitoneum.
  • We report a 51-year-old woman with a fat-containing variant of a solitary fibrous tumor that is the first reported case involving a visceral organ.
  • The tumor was well delineated and seemed to arise from the renal capsule, radiographically and macroscopically.
  • The tumor microscopically mimicked a solitary fibrous tumor but exhibited focal aggregates of fat cells.
  • A fat-containing variant of a solitary fibrous tumor involving the kidney should be distinguished from spindle cell carcinoma, angiomyolipoma, gastrointestinal stromal tumor, and cellular schwannoma.
  • [MeSH-major] Adipose Tissue / pathology. Hemangiopericytoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 15667897.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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81. Zemel MB, Sun X: Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr; 2008 Jun;138(6):1047-52
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  • Accordingly, this study was designed to study the effects of the short-term (3 wk) basal suboptimal Ca (0.4%), high-Ca (1.2% from CaCO(3)), and high-dairy (1.2% Ca from milk) obesigenic diets on oxidative and inflammatory stress in adipocyte fatty acid-binding protein-agouti transgenic mice.
  • Adipose tissue reactive oxygen species (ROS) production and NADPH oxidase mRNA and plasma malondialdehyde (MDA) were reduced by the high-Ca diet (P < 0.001) compared with the basal diet and ROS and MDA were further decreased by the high-dairy diet (P < 0.001).
  • The high-Ca and -dairy diets also resulted in suppression of adipose tissue tumor necrosis factor alpha and interleukin (IL)-6 mRNA (P = 0.001) compared with the basal diet, whereas an inverse pattern was noted for adiponectin and IL-15 mRNA (P = 0.002).
  • These data demonstrate that dietary Ca suppresses adipose tissue oxidative and inflammatory stress.

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  • (PMID = 18492832.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Calcium, Dietary; 0 / Dietary Carbohydrates; 0 / Dietary Fats; 9007-41-4 / C-Reactive Protein
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82. Browne TJ, Fletcher CD: Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology; 2006 Mar;48(4):453-61
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  • [Title] Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity.
  • AIMS: To describe 13 new cases of a rare soft tissue neoplasm currently known as haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL) and to further its characterization.
  • Grossly the lesions were fatty/gelatinous or lipoma-like.
  • Dissecting between adipocytic lobules were septa containing short spindle cells with streaming, swirling or honeycomb growth patterns.
  • CONCLUSIONS: So-called HFHLL, better termed haemosiderotic fibrolipomatous tumour, is a distinct lesion characterized by an admixture of fibroblastic spindle cells, mature adipocytes and haemosiderin pigmentation, shows a predilection for the distal extremities and quite often recurs locally.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16487368.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 9011-92-1 / Hemosiderin
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83. Takahira T, Oda Y, Tamiya S, Yamamoto H, Kobayashi C, Izumi T, Ito K, Iwamoto Y, Tsuneyoshi M: Alterations of the RB1 gene in dedifferentiated liposarcoma. Mod Pathol; 2005 Nov;18(11):1461-70
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  • Dedifferentiated liposarcoma is a malignant adipocytic neoplasm containing a non-lipogenic sarcoma of variable histological grade that arises against the background of a pre-existing well-differentiated liposarcoma.
  • The phenomenon of dedifferentiation is considered to be time-dependent, but the mechanism is not well known.
  • The retinoblastoma protein, encoded by the RB1 gene located at 13q14, is a key regulator of proliferation, development, and differentiation of certain cell types, including adipocytes.
  • [MeSH-major] Liposarcoma / genetics. Retinoblastoma Protein / genetics. Soft Tissue Neoplasms / genetics

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  • [Copyright] .Modern Pathology (2005) 18, 1454-1460. doi:10.1038/modpathol.3800444; published online 20 May 2005.
  • (PMID = 15933756.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein
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84. Sleijfer S, Ray-Coquard I, Papai Z, Le Cesne A, Scurr M, Schöffski P, Collin F, Pandite L, Marreaud S, De Brauwer A, van Glabbeke M, Verweij J, Blay JY: Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol; 2009 Jul 1;27(19):3126-32
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  • [Title] Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043).
  • PURPOSE Given the importance of angiogenesis in soft tissue sarcoma (STS), pazopanib, an oral angiogenesis inhibitor that targets vascular endothelial growth factor receptor and platelet-derived growth factor receptor, was explored in patients with advanced STS.
  • PATIENTS AND METHODS Patients with intermediate- or high-grade advanced STS who were ineligible for chemotherapy or who had received no more than two prior cytotoxic agents for advanced disease, who had documented progression, who had adequate performance status, and who had good organ function were eligible.
  • Four different strata were studied: adipocytic STS, leiomyosarcomas, synovial sarcomas, and other STS types.
  • The adipocytic STS stratum was closed after the first stage, given insufficient activity (PFR(12 weeks), five [26%] of19).
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Pyrimidines / therapeutic use. Sarcoma / drug therapy. Soft Tissue Neoplasms / drug therapy. Sulfonamides / therapeutic use
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality


85. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • [Title] Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation.
  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years.
  • Four tumors predominantly showed features of schwannoma and one of neurofibroma; however, intimately admixed with the spindle cell population, there were also numerous scattered mature adipocytes as well as lipoblast-like cells displaying a signet-ring cell appearance.
  • The signet-ring cells were negative for mucin stains, cytokeratin, EMA, CEA, and several other differentiation markers.
  • The signet-ring cells contained large cytoplasmic lipid droplets that displaced the nuclei to the periphery, consistent with lipoblastic differentiation, whereas complex, interdigitating cytoplasmic processes covered by basal lamina material characteristic of nerve sheath differentiation could be identified in the spindle cells.
  • The presence of mature fat and signet-ring lipoblast-like cells within a nerve sheath neoplasm is quite rare and may signify a process of aberrant differentiation.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-major] Adipose Tissue / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Aust MC, Spies M, Kall S, Jokuszies A, Gohritz A, Vogt P: Posttraumatic lipoma: fact or fiction? Skinmed; 2007 Nov-Dec;6(6):266-70
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  • Lipomas are usually benign adipose tumors with as-yet unexplained pathogenesis and etiology.
  • A link between soft tissue trauma and the formation of lipomas has been described, with the latter being named posttraumatic lipomas.
  • The average time between soft tissue trauma and lipoma formation was 2.6 years (range, 0.5-6.0 years).
  • All tumors were located epifascially.
  • Pathology demonstrated capsulated and noncapsulated benign adipose tumors in 23 cases.
  • CONCLUSIONS: The pathogenetic link between soft tissue trauma and the formation of posttraumatic lipomas is still controversially discussed.
  • There are 2 potential explanations to correlate soft tissue trauma and adipose tissue tumor growth.
  • The first is the formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact.
  • A second possibility points toward lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation.
  • [MeSH-major] Adipose Tissue / injuries. Lipoma / etiology. Neoplasms, Adipose Tissue / etiology. Wounds, Nonpenetrating / complications

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  • (PMID = 17975353.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Svegliati-Baroni G, Candelaresi C, Saccomanno S, Ferretti G, Bachetti T, Marzioni M, De Minicis S, Nobili L, Salzano R, Omenetti A, Pacetti D, Sigmund S, Benedetti A, Casini A: A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol; 2006 Sep;169(3):846-60
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  • [Title] A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.
  • Insulin resistance induces nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH).
  • We used a high-fat, high-calorie solid diet (HFD) to create a model of insulin resistance and NASH in nongenetically modified rats and to study the relationship between visceral adipose tissue and liver.
  • Obesity and insulin resistance occurred in HFD rats, accompanied by a progressive increase in visceral adipose tissue tumor necrosis factor (TNF)-alpha mRNA and in circulating free fatty acids.
  • HFD also decreased adiponectin mRNA and peroxisome proliferator-activated receptor (PPAR)-alpha expression in the visceral adipose tissue and the liver, respectively, and induced hepatic insulin resistance through TNF-alpha-mediated c-Jun N-terminal kinase (JNK)-dependent insulin receptor substrate-1Ser307 phosphorylation.
  • Supplementation of n-3 polyunsaturated fatty acid, a PPARalpha ligand, to HFD-treated animals restored hepatic adiponectin and PPARalpha expression, reduced TNF-alpha hepatic levels, and ameliorated fatty liver and the degree of liver injury.
  • Thus, our model mimics the most common features of NASH in humans and provides an ideal tool to study the role of individual pathogenetic events (as for PPARalpha down-regulation) and to define any future experimental therapy, such as n-3 polyunsaturated fatty acid, which ameliorated the degree of liver injury.
  • [MeSH-major] Fatty Acids, Omega-3 / metabolism. Fatty Liver / metabolism. Insulin Resistance. Intra-Abdominal Fat / metabolism. Liver / metabolism
  • [MeSH-minor] Animals. Apoptosis. Disease Models, Animal. Down-Regulation. Fibrosis / metabolism. Fibrosis / pathology. Food, Formulated / adverse effects. Hepatocytes / metabolism. Hepatocytes / pathology. Humans. Insulin Receptor Substrate Proteins. JNK Mitogen-Activated Protein Kinases / metabolism. Male. Necrosis / metabolism. Necrosis / pathology. Oxidative Stress. Phosphoproteins / metabolism. Protein Processing, Post-Translational. RNA, Messenger / biosynthesis. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / biosynthesis

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  • (PMID = 16936261.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids, Omega-3; 0 / IRS1 protein, human; 0 / Insulin Receptor Substrate Proteins; 0 / Irs1 protein, rat; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases
  • [Other-IDs] NLM/ PMC1698833
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92. Jin MS, Ha HJ, Baek HJ, Lee JC, Koh JS: Adenomyomatous hamartoma of lung mimicking benign mucinous tumor in fine needle aspiration biopsy: a case report. Acta Cytol; 2008 May-Jun;52(3):357-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomyomatous hamartoma of lung mimicking benign mucinous tumor in fine needle aspiration biopsy: a case report.
  • BACKGROUND: Typical cytologic features of pulmonary hamartoma (PH) are usually smears of hyaline cartilage, fibrous tissue, smooth muscle, adipocytic components and respiratory epithelium.
  • Cytologic features of adenomyomatous hamartoma, a special variant of PH, are not documented in the literature and are confused with epithelial neoplasm in the case of sparse stromal cellularity.
  • The patient underwent surgery for the tumor, and it was histologically proven to be an adenomyomatous hamartoma.
  • This case demonstrates the wide spectrum of PH in FNAB and led us to consider PH as a differential diagnosis despite lack of chondromyxoid stromal components.
  • [MeSH-major] Biopsy, Fine-Needle. Hamartoma / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Humans. Male. Middle Aged. Thoracic Surgery, Video-Assisted. Treatment Outcome

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  • (PMID = 18540306.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. de Groot M, Appelman M, Spuls PI, de Rie MA, Bos JD: Initial experience with routine administration of etanercept in psoriasis. Br J Dermatol; 2006 Oct;155(4):808-14
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  • OBJECTIVES: We hypothesized: (i) that efficacy would be lower than that obtained in published phase II and III studies because (a) resistance to all conventional therapies as a reimbursement condition would select for more resistant cases and (b) inclusion would be more restricted to severe cases (higher PASI), and (ii) that efficacy would be lower in obese patients due to the possible role of adipose tissue in tumour necrosis factor (TNF)-alpha homeostasis.
  • Additionally, we related the clinical effect to the body mass index (BMI), for adipose tissue is thought to have a possible role in TNF-alpha homeostasis.
  • Although fatigue is not identified as a side-effect of etanercept, 10% of our patients reported fatigue as an adverse event during etanercept treatment.
  • Finally, the BMI does not seem to influence the patients' response to etanercept, although further investigations would be needed to confirm this.
  • [MeSH-major] Dermatologic Agents / therapeutic use. Immunoglobulin G / therapeutic use. Psoriasis / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use

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  • (PMID = 16965432.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; OP401G7OJC / Etanercept
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94. Walter M, Liang S, Ghosh S, Hornsby PJ, Li R: Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene; 2009 Jul 30;28(30):2745-55
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  • [Title] Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells.
  • Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated.
  • Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model.
  • Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs.
  • Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells.

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  • (PMID = 19483720.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA093506-08; United States / NCI NIH HHS / CA / R01 CA093506; United States / NCI NIH HHS / CA / R01 CA093506-05A1; United States / NCI NIH HHS / CA / CA093506-05A1; United States / NCI NIH HHS / CA / CA93506; United States / NCI NIH HHS / CA / CA093506-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cofilin 1; 0 / Interleukin-6; 0 / ROCK1 protein, human; EC 2.7.11.1 / rho-Associated Kinases
  • [Other-IDs] NLM/ NIHMS111638; NLM/ PMC2806057
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95. Guo J, Zhou S, Rao NP, Pez GH: Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. Appl Immunohistochem Mol Morphol; 2010 Oct;18(5):473-8
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  • Pleomorphic malignant fibrous histiocytoma (MFH), also known as undifferentiated high-grade pleomorphic sarcoma according to the latest World Health Organization classification, is a diagnosis of exclusion and extremely rare in adult scrotal/paratesticular region.
  • Fluorescence in-situ hybridization showed an aneuploid karyotype and negative results for lipomatous tumor abnormalities.
  • The diagnosis of scrotal/paratesticular pleomorphic MFH with concurrent Fournier gangrene was made.


96. Hardes J, Scheil-Bertram S, Hartwig E, Gebert C, Gosheger G, Schulte M: Sonographic findings of hibernoma. A report of two cases. J Clin Ultrasound; 2005 Jul-Aug;33(6):298-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present 2 cases of hibernoma, a rare lipomatous tumor arising from brown fat tissue.
  • In each case, a hyperechoic mass in comparison to surrounding musculature combined with elevated vascularization was highly suggestive of a liposarcoma.
  • Although rare, hibernomas should be considered in the differential diagnosis of lipomatous soft-tissue tumors.
  • [MeSH-major] Adipose Tissue, Brown / ultrasonography. Lipoma / diagnosis. Soft Tissue Neoplasms / diagnosis. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adult. Biopsy, Needle / methods. Buttocks / pathology. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Gadolinium DTPA. Humans. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Male. Rare Diseases. Tomography, X-Ray Computed / methods

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  • (PMID = 16134158.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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97. Sulentić P, Abdović S, Filipović J, Tomas D: Pedunculated myolipoma incidentally found in hernial sac: a case report. Acta Clin Croat; 2009 Jun;48(2):171-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A case of a very rare adipocytic tumor found during corrective surgery for incisional abdominal hernia is presented.
  • During surgery of incisional hernia, a part of small intestine along with a pedunculated tumor was found in hernial sac.
  • The tumor was attached to the medial intra-abdominal peritoneum.
  • On examination, the tumor presented as a totally encapsulated dimorphic benign neoplasm composed of mature adipocytes and well-differentiated smooth muscle cells.
  • Lipoblasts, floret-like giant cells, nuclear atypia, mitosis or proliferation of medium-sized arteries with thick muscular walls were not observed.
  • Tumor cells were negative for HMB45, estrogen and progesterone.
  • The diagnosis of myolipoma was established.
  • This tumor commonly presents as a large quiescent mass in retroperitoneum in adult females and to our knowledge this is the first report of myolipoma in hernial sac.
  • Characteristic findings, differential diagnosis, prognosis and the possible origin of such a neoplasm are discussed.
  • [MeSH-major] Hernia, Abdominal / surgery. Lipoma / diagnosis. Peritoneal Neoplasms / diagnosis

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  • (PMID = 19928417.001).
  • [ISSN] 0353-9466
  • [Journal-full-title] Acta clinica Croatica
  • [ISO-abbreviation] Acta Clin Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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