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1. Faria GR, Eloy C, Preto JR, Costa EL, Almeida T, Barbosa J, Paiva ME, Sousa-Rodrigues J, Pimenta A: Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. J Med Case Rep; 2010;4:351

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report.
  • INTRODUCTION: Most gastric tumors are adenocarcinomas.
  • Primary gastric adenosquamous carcinoma is a rare malignancy, mostly associated with Asian populations.
  • It constitutes less than one percent of all gastric carcinomas and its clinical presentation is the same as adenocarcinoma.
  • It occurs more frequently in the proximal stomach, usually presents with muscular layer invasion and tends to be found in advanced stages at diagnosis, with a worse prognosis than adenocarcinoma.
  • CASE PRESENTATION: We report the case of an 84-year-old Caucasian woman with an adenosquamous carcinoma extending to her serosa with lymphatic and venous invasion (T3N1M1).
  • CONCLUSIONS: Adenosquamous gastric cancer is a rare diagnosis in western populations.
  • We present the case of a woman with a very aggressive adenosquamous carcinoma with a preponderance of squamous cell component in the metastasis.
  • Several origins have been proposed for this kind of carcinoma; either evolution from adenocarcinoma de-differentiation or stem cell origin might be possible.
  • The hypothesis that a particular histological type of gastric cancer may arise from stem cells might be a field of research in oncological disease of the stomach.

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  • (PMID = 21034475.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2984469
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2. Kim YS, Heo WS, Chae KH, Gang YS, Jung JH, Kim SH, Seong JK, Lee BS, Jeong HY, Song KS, Shin KS, Cho JS, Noh SM: [Clinicopathological features and differences of p53 and Ki-67 expression in adenosquamous and squamous cell carcinomas of the stomach]. Korean J Gastroenterol; 2006 Jun;47(6):425-31
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  • [Title] [Clinicopathological features and differences of p53 and Ki-67 expression in adenosquamous and squamous cell carcinomas of the stomach].
  • BACKGROUND/AIMS: This study reviews the clinicopathological features, prognosis, and differences in the expression of p53 and Ki-67 immunochemical staining in squamous cell and adenosquamous carcinoma of the stomach.
  • METHODS: From January 1995 to June 2005, 2,282 cases of gastric carcinoma were resected surgically in our hospital and 191 additional cases were resected by endoscopic mucosal resection.
  • RESULTS: The study consists of eight cases (0.032%) of primary squamous cell carcinoma (one case) and adenosquamous carcinoma (seven cases) without early gastric cancer.
  • At the initial diagnosis, six (75%) were stage IV based on TNM tumor staging.
  • CONCLUSIONS: Adenosquamous and squamous cell carcinoma of the stomach are very rare.
  • They tend to be at advanced stages on initial diagnosis, and progress rapidly.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Carcinoma, Squamous Cell / pathology. Ki-67 Antigen / analysis. Stomach Neoplasms / pathology. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16809949.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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3. Went P, Vasei M, Bubendorf L, Terracciano L, Tornillo L, Riede U, Kononen J, Simon R, Sauter G, Baeuerle PA: Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers. Br J Cancer; 2006 Jan 16;94(1):128-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers.
  • We analysed by immunohistochemical staining tissue microarrays with 4046 primary human carcinoma samples from colon, stomach, prostate and lung cancers for both frequency and intensity of Ep-CAM expression under highly standardised conditions.
  • High-level Ep-CAM expression was observed in 97.7% (n=1186) of colon, 90.7% of gastric (n=473), and 87.2% of prostate cancers (n=414), and in 63.9% of lung cancers (n=1287).
  • No detectable Ep-CAM staining was found with only 0.4% of colon, 2.5% of gastric, 1.9% of prostate cancers, and 13.5% of lung cancers.
  • Adenosquamous and squamous carcinomas of the lung had a lower percentage of high-level Ep-CAM expression compared to adenocarcinomas with 35.4 and 53.6%, respectively, and with 45.5 and 17.3% of tumours being Ep-CAM negative.
  • With the exception of moderately differentiated colon carcinoma, where patients not expressing Ep-CAM on their tumours showed an inferior survival (P=0.0014), correlation of Ep-CAM expression with survival did not reach statistical significance for any of the other cancer indications and subgroups.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Cell Adhesion Molecules / biosynthesis. Colonic Neoplasms / genetics. Lung Neoplasms / genetics. Neoplasm Staging. Prostatic Neoplasms / genetics. Stomach Neoplasms / genetics

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  • (PMID = 16404366.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human
  • [Other-IDs] NLM/ PMC2361083
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4. Shutoh M, Oue N, Aung PP, Noguchi T, Kuraoka K, Nakayama H, Kawahara K, Yasui W: DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. Cancer; 2005 Oct 15;104(8):1609-19
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  • [Title] DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation.
  • To the authors' knowledge, little is known regarding the involvement of these three genes in gastric carcinoma (GC).
  • None of the 10 normal gastric mucosa samples from young, healthy individuals demonstrated hypermethylation of any of these genes.
  • CONCLUSIONS: The results suggested that gastric carcinogenesis involves transcriptional inactivation by aberrant DNA methylation of genes related to retinoid signaling.
  • [MeSH-major] DNA Methylation. Gene Expression Regulation, Neoplastic. Membrane Proteins / genetics. Receptors, Retinoic Acid / genetics. Retinoids / pharmacology. Retinol-Binding Proteins / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Azacitidine / pharmacology. Carcinoma, Adenosquamous / genetics. Carcinoma, Adenosquamous / pathology. Female. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Gene Silencing. Genes, Tumor Suppressor. Humans. Intestinal Neoplasms / genetics. Intestinal Neoplasms / pathology. Male. Metaplasia / genetics. Metaplasia / pathology. Middle Aged. Promoter Regions, Genetic / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Retinol-Binding Proteins, Cellular. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Transcription, Genetic. Tumor Cells, Cultured

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  • [Copyright] Copyright 2005 American Cancer Society
  • (PMID = 16134180.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / RARRES1 protein, human; 0 / RBP1 protein, human; 0 / RNA, Messenger; 0 / Receptors, Retinoic Acid; 0 / Retinoids; 0 / Retinol-Binding Proteins; 0 / Retinol-Binding Proteins, Cellular; 0 / retinoic acid receptor beta; M801H13NRU / Azacitidine
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5. Kuroda N, Oonishi K, Inoue K, Ohara M, Mizuno K, Lee GH: Lymphoepithelioma-like carcinoma of the stomach associated with adenosquamous carcinoma. Med Mol Morphol; 2010 Sep;43(3):170-3
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  • [Title] Lymphoepithelioma-like carcinoma of the stomach associated with adenosquamous carcinoma.
  • Lymphoepithelioma-like carcinoma and adenosquamous carcinoma of the stomach are relatively rare tumors.
  • To date, there are no reports on lymphoepithelioma-like carcinoma of the stomach associated with adenosquamous carcinoma.
  • The gastric endoscopy revealed an ulcerative cancerous lesion of the upper portion.
  • Histological examination of the gastric tumor showed the coexistence of lymphoepithelioma-like carcinoma and adenosquamous carcinoma.
  • This pattern resembled mucoepidermoid carcinoma in the salivary gland.
  • Finally, this is the first case of gastric lymphoepithelioma-like carcinoma associated with adenosquamous carcinoma, and clinicians and pathologists should recognize the presence of such a tumor.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Lymphoma / pathology. Stomach Neoplasms / pathology

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  • (PMID = 20857266.001).
  • [ISSN] 1860-1499
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA-Binding Proteins; 0 / Ribosomal Proteins; 135844-68-7 / RPL22 protein, human
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6. Nomura M, Inoue Y, Fujita S, Sakao J, Hirota M, Souda S: [A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy]. Gan To Kagaku Ryoho; 2006 Jan;33(1):99-103
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  • [Title] [A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy].
  • An endoscopic examination revealed type 2 cancer from the upper body of the stomach to the antrum, and abdominal CT scan demonstrated enlarged abdominal paraaortic lymph nodes.
  • The preoperative diagnosis was cStage IV gastric cancer (cT 3, cN 3, cH 0, cP 0, cM 0).
  • Histopathologically, the tumor was diagnosed as adenosquamous carcinoma of the stomach with lymph node metastasis at only No.3.
  • This case suggests that neoadjuvant chemotherapy using TS-1 plus CDDP is effective for advanced gastric adenosquamous carcinoma with massive lymph node metastases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenosquamous / drug therapy. Carcinoma, Adenosquamous / secondary. Lymph Nodes / pathology. Stomach Neoplasms / pathology

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  • (PMID = 16410707.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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7. Endo K, Kohnoe S, Okamura T, Haraguchi M, Adachi E, Toh Y, Baba H, Maehara Y: Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor. Gastric Cancer; 2005;8(3):173-7
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  • [Title] Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor.
  • We report a case of adenosquamous carcinoma of the stomach that produced granulocyte-colony stimulating factor (G-CSF).
  • The patient, who had an admission diagnosis of advanced gastric cancer, had marked leukocytosis without evidence of infection.
  • The resected stomach tumor was histologically diagnosed as adenosquamous carcinoma; positive expression of G-CSF by tumor cells was shown with immunohistochemical detection, which confirmed the preoperative diagnosis.
  • [MeSH-major] Carcinoma, Adenosquamous / metabolism. Granulocyte Colony-Stimulating Factor / metabolism. Leukocytosis / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 16086120.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
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8. Wei WZ, Yu JP, Li J, Liu CS, Zheng XH: Evaluation of contrast-enhanced helical hydro-CT in staging gastric cancer. World J Gastroenterol; 2005 Aug 7;11(29):4592-5
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  • [Title] Evaluation of contrast-enhanced helical hydro-CT in staging gastric cancer.
  • AIM: To discuss the helical computed tomography (CT) characteristics of gastric cancer and evaluate the diagnostic value of contrast-enhanced helical hydro-CT (HHCT) in staging gastric cancer.
  • METHODS: A total of 50 patients with gastric cancer were included in this study.
  • RESULTS: The foci of gastric cancer became more prominent in all the 50 patients and showed strong enhancement in contrast-enhanced HHCT.
  • The tumor was located at the gastric cardia in 14 cases, at the gastric fundus in 3 cases, at the gastric body in 8 cases, at the gastric antrum in 4 cases, at the gastric fundus and the body in 8 cases, at the gastric body and antrum in 11 cases, and at three segments of the stomach in 2 cases.
  • The CT features of gastric cancer were focal or diffuse mural thickening, soft tissue mass, cancerous ulcer, stenosis of stomach, infiltration to adjacent tissues, lymph node and distant metastases.
  • Strong contrast enhancement of the gastric wall was closely related to gastric cancer.
  • The accuracy rate of contrast-enhanced HHCT in staging gastric cancer was 86% (43/50).
  • CONCLUSION: Contrast-enhanced HHCT is a reliable method to diagnose and stage gastric cancer.
  • [MeSH-major] Carcinoma, Papillary / radiography. Neoplasm Staging / methods. Stomach Neoplasms / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adult. Aged. Aged, 80 and over. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiography. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiography. Contrast Media. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16052695.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC4398715
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9. Ishiguro A, Takahata T, Hirose K, Matsumoto Y, Tanaka S, Suzuki K, Hanada N, Itoh J, Kawasaki H, Kijima H, Fukuda S, Saijo Y: [A case of gastric adenosquamous carcinoma successfully treated with second-line chemotherapy (CPT-11 and CDDP)]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1579-82
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  • [Title] [A case of gastric adenosquamous carcinoma successfully treated with second-line chemotherapy (CPT-11 and CDDP)].
  • Gastric adenosquamous carcinoma is known as an infrequent histological cancer with a poor prognosis.
  • A 69-year-old man was revealed to have gastric squamous carcinoma on the gastric body remote from esophagus (cT4 cN3, cStage IV).
  • The final histological diagnosis showed gastric adenosquamous carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Carcinoma, Adenosquamous / drug therapy. Cisplatin / therapeutic use. Stomach Neoplasms / drug therapy

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  • (PMID = 20716891.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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10. Tohma T, Yamamoto Y, Seki Y, Takaishi S, Sakuma Y, Funami Y, Tobita K: Weekly paclitaxel therapy is effective for gastric adenosquamous carcinoma: a case report. Hepatogastroenterology; 2009 Mar-Apr;56(90):568-70
Hazardous Substances Data Bank. TAXOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Weekly paclitaxel therapy is effective for gastric adenosquamous carcinoma: a case report.
  • On endoscopy, a type 3 cancer from the lower body of the stomach to the antrum was found, and abdominal CT scan demonstrated multiple liver metastases and peritoneal dissemination.
  • On, pathological examination, a diagnosis of adenosquamous carcinoma was confirmed, and lymph node metastases around the perigastric areas were found.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Adenosquamous / drug therapy. Paclitaxel / therapeutic use. Stomach Neoplasms / drug therapy

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  • (PMID = 19579645.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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11. Ikeda E, Shigematsu T, Hidaka K, Nishikawa A, Katayama M, Okajima T, Kawahara T, Tanaka M, Banba M: [A case of adenosquamous gastric carcinoma successfully treated with TS-1, low-dose CDDP and docetaxel as neoadjuvant chemotherapy]. Gan To Kagaku Ryoho; 2007 Mar;34(3):423-6
Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

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  • [Title] [A case of adenosquamous gastric carcinoma successfully treated with TS-1, low-dose CDDP and docetaxel as neoadjuvant chemotherapy].
  • The patient was a 66-year-old male with extremely advanced gastric cancer type 3 and diagnosed with adenocarcinoma by endoscopic biopsies specimens.
  • However, it proved effective and feasible as a neoadjuvant chemotherapy regimen for advanced gastric cancer.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenosquamous / drug therapy. Stomach Neoplasms / drug therapy

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  • (PMID = 17353635.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Taxoids; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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12. Fujita T, Fukuda K, Ohmura Y, Nishi H, Mano M, Komatsubara S, Doihara H, Shimizu N: Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection. J Hepatobiliary Pancreat Surg; 2005;12(2):147-50
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection.
  • Patients with adenosquamous carcinoma of the gallbladder tend to present with a bulky tumor that frequently displays involvement with adjacent organs, and diagnosis is usually made at an advanced stage.
  • This may contribute to the poor prognosis of patients with adenosquamous carcinoma of the gallbladder compared to patients with adenocarcinoma.
  • We present herein a patient with advanced adenosquamous carcinoma of the gallbladder who is doing well with no evidence of recurrence more than 5 years after radical resection.
  • On admission, abdominal ultrasonography and computed tomography revealed an irregularly shaped solid mass extending from the fundus of the gallbladder, and invasion of the stomach was strongly suspected.
  • Gallbladder carcinoma was diagnosed, and radical resection, including partial gastrectomy, was performed.
  • Histopathologically, adenosquamous carcinoma was diagnosed, and it was graded as si, hinf0, binf0, pv0, a0, t4, n0, and stage IVa.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Gallbladder Neoplasms / surgery

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  • (PMID = 15868080.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Satoh M, Wakabayashi O, Araya Y, Jinushi E, Yoshida F: [Autopsy case of von Recklinghausen's disease associated with lung cancer, gastrointestinal stromal tumor of the stomach, and duodenal carcinoid tumor]. Nihon Kokyuki Gakkai Zasshi; 2009 Sep;47(9):798-804
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  • [Title] [Autopsy case of von Recklinghausen's disease associated with lung cancer, gastrointestinal stromal tumor of the stomach, and duodenal carcinoid tumor].
  • Autopsy revealed multiple emphysematous bullae, poorly differentiated adenosquamous cell carcinoma of the lung, gastrointestinal stromal tumor of the stomach, and duodenal carcinoid tumor.
  • [MeSH-major] Autopsy. Carcinoid Tumor / etiology. Carcinoma, Adenosquamous / etiology. Duodenal Neoplasms / etiology. Gastrointestinal Stromal Tumors / etiology. Lung Neoplasms / etiology. Neoplasms, Multiple Primary. Neurofibromatosis 1 / complications
  • [MeSH-minor] Fatal Outcome. Humans. Male. Middle Aged. Pulmonary Emphysema / complications. Pulmonary Emphysema / diagnosis. Pulmonary Emphysema / pathology. Risk Factors

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  • (PMID = 19827584.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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14. Yie SM, Yang H, Ye SR, Li K, Dong DD, Lin XM: Expression of human leukocyte antigen G (HLA-G) correlates with poor prognosis in gastric carcinoma. Ann Surg Oncol; 2007 Oct;14(10):2721-9
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of human leukocyte antigen G (HLA-G) correlates with poor prognosis in gastric carcinoma.
  • Currently, we investigate whether or not HLA-G is also expressed in patients with gastric carcinoma and whether the expression has any clinical application value.
  • METHODS: The expression of HLA-G was investigated immunohistochemically in 160 patients with gastric carcinoma.
  • RESULTS: HLA-G protein expression was observed in 71% (113 of 160) of the primary site of gastric carcinomas, but not in the normal stomach tissues.
  • CONCLUSIONS: Overall, our results indicated that the expression of HLA-G is a characteristic feature of gastric carcinoma and that immunostaining by anti-HLA-G antibody may be a potentially useful prognostic indicator.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carcinoma, Adenosquamous / pathology. Carcinoma, Signet Ring Cell / pathology. HLA Antigens / analysis. Histocompatibility Antigens Class I / analysis. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Antibodies, Monoclonal. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Gastrectomy. HLA-G Antigens. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Pregnancy. Prognosis. Statistics as Topic. Stomach / pathology. Survival Rate. Trophoblasts / pathology

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  • (PMID = 17564748.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / HLA Antigens; 0 / HLA-G Antigens; 0 / Histocompatibility Antigens Class I
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15. Xiong HC, Zhang LJ, Yang Y, Liang Z, Wu N, Chen JF: [Clinical analysis of 123 gastric cardia carcinoma patients treated with surgical operation]. Ai Zheng; 2006 Jan;25(1):100-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 123 gastric cardia carcinoma patients treated with surgical operation].
  • BACKGROUND & OBJECTIVE: The prevalence of gastric cardia carcinoma is increasing in recent decades, necessitating further research on it.
  • This study was to summarize our experiences in surgical treatment of gastric cardia carcinoma.
  • METHODS: A total of 123 gastric cardia carcinoma patients, received surgical operation, were divided into 3 groups according to surgical approaches: 72 in thoracic group, 40 in abdominal group, and 11 in thoracoabdominal group.
  • RESULTS: Setting pathologic results as golden standard, the correct diagnosis rates of preoperative ultrasound for serosal involvement, lymph node metastasis, distal esophageal involvement, and others (including liver metastases, extended invasion, and ascites) were 71.2%, 62.2%, 47.8%, and 100%, respectively; those of CT were 78.6%, 72.7%, 51.9%, and 100%, respectively.
  • The curative resection rate was 94.3% (116/123); among the 116 cases, 108 (93.1%) were adenocarcinoma, 2 were squamous cell carcinoma, 2 were adenosquamous carcinoma, 2 were atypical carcinoid, and 2 were carcinoid; 84 (72.4%) had abdominal lymph node metastases, 6 (7.1%) had thoracic lymph node metastases, and 40 (34.5%) had distal esophageal involvement.
  • CONCLUSIONS: Preoperative abdominal ultrasound and thoracoabdominal CT scan are helpful in evaluating respectability of gastric cardia carcinoma.
  • Abdominal lymph node is the main route of lymphatic dissemination of gastric cardia carcinoma.
  • [MeSH-major] Cardia / surgery. Gastrectomy / methods. Stomach Neoplasms / surgery

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  • (PMID = 16405761.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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16. Güdücüoğlu H, Berktaş M, Bozkurt H, Toka Ozer T, Bulut G, Oztürk O, Ilhan M: [Evaluation of Western Blot method for the detection of antibodies to Helicobacter pylori antigens in patients with gastric carcinoma and cases with epigastric complaints]. Mikrobiyol Bul; 2010 Jan;44(1):21-8
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  • [Title] [Evaluation of Western Blot method for the detection of antibodies to Helicobacter pylori antigens in patients with gastric carcinoma and cases with epigastric complaints].
  • CagA gene carrying H. pylori strains are particularly associated with gastric adenocarsinoma.
  • This study was conducted to evaluate Western Blot (WB) method to determine specific H. pylori antibodies in a group of patients with gastric cancer and in a control group with no malignancy.
  • A total of 99 patients with gastric cancer (94 adenocarcinoma, 2 adenosquamous cell carcinoma, 3 non-Hodgkin lymphoma) and 150 control cases with epigastric complaints such as nausea, vomiting, diarrhea, gastroesophageal reflux and abdominal pain, were included to the study. H. pylori IgG-ELISA was positive in all study (mean age: 56.7 +/- 1.2 years, 62 male) and control (mean age: 24.2 +/- 1.3 years, 64 male) patients.
  • The positivity rates for H. pylori CagA, OMP-67, urease A, urease-B, flagellin and HSP specific antibodies were as 78%, 54%, 37%, 60%, 53% and 82% in the gastric cancer group and 85%, 71%, 55%, 43%, 61% and 75% in the control group, respectively.
  • There was no statistically significant difference (p > 0.05) between gastric carcinoma and control groups in terms of CagA, HSP and flagellin antibodies (p > 0.05).
  • [MeSH-major] Antibodies, Bacterial / blood. Blotting, Western / standards. Gastrointestinal Diseases / microbiology. Helicobacter pylori / immunology. Stomach Neoplasms / microbiology

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  • (PMID = 20455395.001).
  • [ISSN] 0374-9096
  • [Journal-full-title] Mikrobiyoloji bülteni
  • [ISO-abbreviation] Mikrobiyol Bul
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Antigens, Bacterial; 0 / Bacterial Proteins; 0 / VacA protein, Helicobacter pylori; 0 / cagA protein, Helicobacter pylori
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17. Dincer Y, Himmetoglu S, Akcay T, Ersoy EY, Gunes KN, Tortum O: Prognostic significances of oxidative DNA damage evaluated by 8-hydroxy-deoxyguanosine and antioxidant enzymes in patients undergoing resection of gastric and colon carcinoma. Neoplasma; 2007;54(2):131-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [Title] Prognostic significances of oxidative DNA damage evaluated by 8-hydroxy-deoxyguanosine and antioxidant enzymes in patients undergoing resection of gastric and colon carcinoma.
  • In order to determine whether the degree of oxidative DNA damage and antioxidant enzyme activities in plasma obtained from patients with gastric and colon cancer who undergo resection can be used as a useful prognostic predictor, plasma level of 8-hydroxydeoxyguanosine (8-OHdG), activities of glutathione peroxidase (G-Px) and superoxide dismutase (SOD) were examined.
  • 19 patients with gastric cancer and 26 patients with colon cancer who were undergoing resection of tumor were included by the study.
  • 8-OHdG level and activity of G-Px were found to be decreased, SOD activity was found to be increased in both gastric and colon cancer groups as compared to control group.
  • Alpha fetoprotein was found to be correlated with G-Px in the gastric cancer group and correlated with 8-OHdG in the colon cancer group.
  • SOD activity was correlated with CA-15-3 in the gastric cancer group.
  • Low plasma level of 8-OHdG and altered antioxidant activity may implicate the deficient repair of oxidative DNA damage in patients with gastric and colon cancer.
  • [MeSH-major] Antioxidants / metabolism. Colonic Neoplasms / blood. DNA Damage. Deoxyguanosine / analogs & derivatives. Glutathione Peroxidase / blood. Stomach Neoplasms / blood. Superoxide Dismutase / blood
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / secondary. Aged. Carcinoma, Adenosquamous / blood. Carcinoma, Adenosquamous / secondary. Carcinoma, Signet Ring Cell / blood. Carcinoma, Signet Ring Cell / secondary. Case-Control Studies. Enzyme-Linked Immunosorbent Assay. Female. Humans. Lymphoma, B-Cell / blood. Lymphoma, B-Cell / pathology. Male. Middle Aged. Oxidation-Reduction. Prognosis. alpha-Fetoproteins

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  • (PMID = 17319786.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Antioxidants; 0 / alpha-Fetoproteins; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase; G9481N71RO / Deoxyguanosine
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18. Lee HS, Kim MS, Lee JM, Kim SK, Kang KW, Zo JI: Intrathoracic gastric emptying of solid food after esophagectomy for esophageal cancer. Ann Thorac Surg; 2005 Aug;80(2):443-7
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrathoracic gastric emptying of solid food after esophagectomy for esophageal cancer.
  • BACKGROUND: Information on the function of the intrathoracic stomach after esophageal resection for esophageal cancer is limited.
  • This study evaluated the factors affecting intrathoracic gastric emptying of solid food in patients who had undergone this surgery.
  • METHODS: Between February 2003 and August 2003, intrathoracic gastric emptying of solid food was evaluated by radioisotope in 56 of the patients who underwent esophageal replacement surgery with the stomach for esophageal cancer.
  • The 50% gastric emptying time was categorized into three ranges: over 180 minutes was defined as delayed, within 180 minutes as intermediate, and when all the radioisotopes were dumped into the jejunum as rapid.
  • The factors affecting the gastric emptying were analyzed.
  • RESULTS: In 6 out of 56 (10.7%) patients the radioisotope removal was too rapid to check the gastric-emptying time, and hence the analysis was performed in 50 patients.
  • Twenty-one (37.5%) patients showed significantly delayed gastric emptying.
  • The 50% gastric emptying time calculated by an exponential fitting method was 422 and 109 minutes in the delayed and intermediate groups, respectively.
  • Age, the method of gastric drainage, and the stomach shape used did not affect the intrathoracic gastric emptying.
  • Only the follow-up interval after surgery was a significant factor on gastric emptying (p = 0.024).
  • The intrathoracic gastric emptying of solid food was more and more increased over time after surgery by regression analysis (p = 0.03).
  • CONCLUSIONS: The use of the intrathoracic stomach as an esophageal substitute had a significant effect on gastric emptying, with intrathoracic gastric emptying of solid foods immediately after esophagectomy being markedly prolonged in about 50% of patients.
  • However, the intrathoracic gastric emptying significantly increased over time.
  • Research is required into improving intrathoracic gastric emptying in the early period after esophagectomy.
  • [MeSH-major] Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Gastric Emptying
  • [MeSH-minor] Carcinoma, Adenosquamous / surgery. Female. Food. Humans. Male. Middle Aged. Stomach / physiology. Stomach / surgery. Thoracic Cavity

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  • [CommentIn] Ann Thorac Surg. 2005 Aug;80(2):447-8 [16039183.001]
  • (PMID = 16039182.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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19. Bilal A, Baseer A, Ahmad M, Imran M, Abid M, Kalimullah M: Early results of oesophagectomy for carcinoma oesophagus in 1008 cases. J Ayub Med Coll Abbottabad; 2010 Oct-Dec;22(4):109-14
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early results of oesophagectomy for carcinoma oesophagus in 1008 cases.
  • OBJECTIVE: To determine the early results of 1008 oesophagectomies done for carcinoma oesophagus over a 9 years period.
  • Of the 611 lower 1/3 tumours stomach involvement was present in 271 (44.35%) cases.
  • Adenocarcinoma was present in 516 (51.19%) cases, squamous cell carcinoma was present in 485 (48.11%), adenosquamous was 6 (0.59%) and carcinoma in situ was present in 1 case (0.09%).
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Esophageal Neoplasms / surgery. Esophagectomy

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  • (PMID = 22455275.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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20. Robledo-Ogazón F, Vargas-Rivas A, Hernández-Ramírez DA, Castellanos-Juárez JC: [Congenital diaphragmatic adult hernia. Case report]. Cir Cir; 2008 Jan-Feb;76(1):61-4
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  • Diagnosis is incidental or when it becomes symptomatic.
  • Our objective was to offer the general surgeon a differential diagnosis for presence of noncardiac thoracic pain in the adult.
  • Postero-anterior x-ray of the thorax demonstrated the presence of the stomach in the thoracic cavity.
  • The patient underwent abdominal surgery where a large diaphragmatic hernia was found with the complete stomach and small bowel inside.
  • It is important that the surgeon establishes an etiological diagnosis in order to offer appropriate treatment.
  • CONCLUSIONS: Congenital diaphragmatic hernia in the adult is rarely suspected in the differential diagnosis of noncardiac thoracic pain.
  • The surgeon must keep this in mind, especially in patients of advanced age, even when cardiac and/or gastrointestinal diagnosis is confirmed.
  • [MeSH-minor] Age of Onset. Aged. Carcinoma, Adenosquamous / complications. Carcinoma, Adenosquamous / radiography. Carcinoma, Adenosquamous / surgery. Cholecystectomy. Cholelithiasis / complications. Cholelithiasis / surgery. Cough / etiology. Diagnostic Errors. Dyspepsia / diagnosis. Female. Gallbladder Neoplasms / complications. Gallbladder Neoplasms / radiography. Gallbladder Neoplasms / surgery. Gastroesophageal Reflux / etiology. Heart Diseases / diagnosis. Hernia, Diaphragmatic / complications. Hernia, Diaphragmatic / diagnosis. Hernia, Diaphragmatic / epidemiology. Humans. Incidental Findings. Lung Diseases / diagnosis. Tomography, X-Ray Computed


21. Huang Q, Zhang LH: The histopathologic spectrum of carcinomas involving the gastroesophageal junction in the Chinese. Int J Surg Pathol; 2007 Jan;15(1):38-52
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An unusual spectrum of tumor differentiation was observed, including adenocarcinomas (83%), adenosquamous (32%), colloid (2%), signet-ring (10%), squamous (5%), oncocytic (7%), pancreatic acinar (12%), and neuroendocrine (5%) carcinomas.
  • The adjacent gastric cardiac mucosa showed hyperplasia, oncocytic, and pancreatic acinar metaplasia, and mild chronic inflammation.
  • [MeSH-major] Carcinoma / pathology. Esophageal Neoplasms / pathology. Esophagogastric Junction / pathology. Stomach Neoplasms / pathology

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  • (PMID = 17172496.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Oue N, Sentani K, Noguchi T, Ohara S, Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K, Yasui W: Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. Int J Cancer; 2009 Nov 15;125(10):2383-92
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients.
  • Gastric cancer (GC) is 1 of the most common human cancers.
  • [MeSH-major] Adenocarcinoma / blood. Biomarkers, Tumor / blood. Carcinoma, Adenosquamous / blood. Granulocyte Colony-Stimulating Factor / blood. Lectins, C-Type / blood. Stomach Neoplasms / blood

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  • (PMID = 19670418.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Lectins, C-Type; 0 / OLFM4 protein, human; 0 / REG4 protein, human; 0 / RNA, Messenger; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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23. Eickhoff A, Knoll M, Jakobs R, Weickert U, Hartmann D, Schilling D, Eickhoff JC, Riemann JF: Self-expanding metal stents versus plastic prostheses in the palliation of malignant dysphagia: long-term outcome of 153 consecutive patients. J Clin Gastroenterol; 2005 Nov-Dec;39(10):877-85
MedlinePlus Health Information. consumer health - Swallowing Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / surgery. Coated Materials, Biocompatible / economics. Coated Materials, Biocompatible / therapeutic use. Cost-Benefit Analysis. Esophageal Neoplasms / surgery. Female. Follow-Up Studies. Germany. Humans. Male. Middle Aged. Prosthesis Design / instrumentation. Recurrence. Retrospective Studies. Stomach Neoplasms / surgery. Time Factors. Treatment Outcome

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  • (PMID = 16208111.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible; 0 / Metals; 0 / Plastics
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24. Satiroglu-Tufan NL, Bir F, Calli-Demirkan N: Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients. World J Gastroenterol; 2006 May 28;12(20):3283-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients.
  • AIM: To investigate both whether the risk of gastric cancer is associated with the Ile/Val single nucleotide polymorphism (SNP) of human epidermal growth factor receptor-2 (HER-2) transmembrane domain-coding region at codon 655 and the suggested existence of HER-2 expression in gastric cancer cases in a Turkish patient group.
  • The results were compared between gastric carcinoma group and chronic gastritis group, as well as between clinicopathological parameters and carcinoma.
  • RESULTS: Results showed that Ile/Val genotype accounted for 20% within the Turkish gastric carcinoma group, and none in chronic gastritis group, and this genotyping was associated with stage IV gastric cancers (P=0.04).
  • Positive membranous HER-2 immunoreactivity, on the other hand, accounted for 24% within the Turkish gastric carcinoma group and none from chronic gastritis cases; further, it was correlated with intestinal type carcinomas (P=0.007), and stage III-IV carcinomas (P=0.004).
  • CONCLUSION: These observations imply that the tested HER-2 SNP may participate in the development and progression of gastric cancer.
  • Thus, after confirming these results with large sample groups, HER-2 codon 655 SNP and/or c-erbB-2 overexpression may also be used as a poor prognostic indicator for gastric carcinomas.
  • [MeSH-major] Carcinoma, Adenosquamous / genetics. Codon / genetics. Gene Expression Regulation, Neoplastic / genetics. Genes, erbB-2 / genetics. Polymorphism, Single Nucleotide. Receptor, ErbB-2 / genetics. Stomach Neoplasms / genetics

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  • (PMID = 16718853.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Codon; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ PMC4087976
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25. Blázquez S, Raventós A, Díaz ML, García-Fontgivell JF, Martínez S, Sirvent JJ: Adenosquamous gastric carcinoma in Caucasian patient. Rev Esp Enferm Dig; 2005 Mar;97(3):211-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous gastric carcinoma in Caucasian patient.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. European Continental Ancestry Group. Female. Humans. Middle Aged

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  • (PMID = 15839815.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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