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1. Lada PE, Taborda B, Sánchez M, Tommasino J, Rosso FF, Gramática L, Alecha Gil J, Echenique Elizondo M: [Adenosquamous and squamous carcinoma of the gallbladder]. Cir Esp; 2007 Apr;81(4):202-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenosquamous and squamous carcinoma of the gallbladder].
  • [Transliterated title] Carcinoma adenoescamoso y epidermoide de la vesícula biliar.
  • INTRODUCTION: Squamous and adenosquamous carcinomas of the gallbladder have poor prognosis.
  • MATERIAL AND METHOD: We performed a retrospective observational study of five patients with squamous or adenosquamous carcinoma of the gallbladder.
  • Pathologic analysis revealed epidermoid carcinoma in two patients and adenosquamous carcinoma in three patients.
  • CONCLUSIONS: In both histological types of gallbladder carcinoma, treatment depends on the grade of local and regional invasion and tumor spread at diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 17403356.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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2. Khoo JJ, Nurul AM: A clinicopathological study of nine cases of gallbladder carcinoma in 1122 cholecystectomies in Johor, Malaysia. Malays J Pathol; 2008 Jun;30(1):21-6
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  • [Title] A clinicopathological study of nine cases of gallbladder carcinoma in 1122 cholecystectomies in Johor, Malaysia.
  • An audit of 1122 cholecystectomies for a 6-year period from 2000 to 2005 was done to review cases of primary carcinoma of gallbladder.
  • There were nine cases of primary carcinoma of gallbladder.
  • Pre-operatively, only 2 (11.1%) were clinically suspected of carcinoma while 3 were diagnosed as cholecystitis, two as cholelithiasis and one case each of ovarian cyst and intestinal obstruction.
  • Intra-operatively, an additional four cases were suspected as gallbladder carcinoma with the remaining three cases diagnosed as only having gallstones.
  • Six (66.67%) cases of gallbladder carcinoma had abnormal macroscopical lesions noted; either papillary lesions or polypoid masses.
  • Of these, two were papillary carcinoma and one signet ring cell type adenocarcinoma.
  • One case of squamous cell carcinoma and one case of adenosquamous carcinoma were noted.
  • This study highlights the importance of careful macroscopical and microscopical evaluation of a routine pathological examination of gallbladder removed for cholecystitis or cholelithiasis.
  • It provides the incidence of gallbladder carcinoma in patients who underwent cholecystectomies in a government hospital in Johor, Malaysia.
  • [MeSH-major] Carcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystectomy. Cholecystitis / complications. Cholecystitis / pathology. Diagnosis, Differential. Female. Gallstones / complications. Gallstones / pathology. Humans. Malaysia. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19108407.001).
  • [ISSN] 0126-8635
  • [Journal-full-title] The Malaysian journal of pathology
  • [ISO-abbreviation] Malays J Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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3. Tadokoro H, Shigihara T, Ikeda T, Takase M, Suyama M: Two distinct pathways of p16 gene inactivation in gallbladder cancer. World J Gastroenterol; 2007 Dec 21;13(47):6396-403
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  • [Title] Two distinct pathways of p16 gene inactivation in gallbladder cancer.
  • AIM: To examine the mechanism of inactivation of the p16 gene in gallbladder cancer, and to investigate p16 alterations and their correlation with clinicopathological features.
  • METHODS: Specimens were collected surgically from 51 patients with gallbladder cancer.
  • Homozygous deletion, a combination of LOH and promoter hypermethylation, and multiple LOH are major mechanisms of p16 inactivation in gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / genetics. Carcinoma, Adenosquamous / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Gallbladder Neoplasms / genetics. Gene Expression Regulation, Neoplastic. Gene Silencing. Genes, p16

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  • (PMID = 18081229.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
  • [Other-IDs] NLM/ PMC4205459
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4. Horio T, Ogata S, Sugiura Y, Aiko S, Kanai N, Matsunaga H, Maehara T: Cholecystic adenosquamous carcinoma mimicking Mirizzi syndrome. Can J Surg; 2009 Jun;52(3):E71-2
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  • [Title] Cholecystic adenosquamous carcinoma mimicking Mirizzi syndrome.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Cholecystolithiasis / diagnosis. Cholestasis / diagnosis. Cholestasis, Extrahepatic / diagnosis. Gallbladder Neoplasms / diagnosis. Jaundice, Obstructive / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Syndrome

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  • (PMID = 19503654.001).
  • [ISSN] 1488-2310
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2689754
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5. Löhe F, Meimarakis G, Schauer C, Angele M, Jauch KW, Schauer RJ: The time of diagnosis impacts surgical management but not the outcome of patients with gallbladder carcinoma. Eur J Med Res; 2009 Aug 12;14(8):345-51
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  • [Title] The time of diagnosis impacts surgical management but not the outcome of patients with gallbladder carcinoma.
  • BACKGROUND: Only 50% of gallbladder cancers (GBC) are recognized before operation and the remaining tumors are diagnosed during surgery or afterwards by the pathologist.
  • Therefore, the time of diagnosis may strongly influence the surgical management of GBC and the prognosis of the patients.
  • METHODS: Records and follow- up of 152 patients with gallbladder carcinoma who underwent surgery between 1980 and 2004 were examined according to the time of diagnosis, TNM staging system, surgical procedures, morbidity and predictors of survival.
  • There were 76 patients with preoperative diagnosis of GBC (50%; group1), 44 patients with intraoperative diagnosis (29%; group 2) and 32 patients (21%; group 3) with postoperatively incidental finding of GBC.
  • Tumor stage, in particular the nodal status and radicality of the procedure, but not the time of diagnosis were the most powerful predictors of outcome.
  • Although the time of diagnosis of GBC causes significant changes of the intended procedures during and after surgery, it has no influence on the prognosis provided that radical (R0) resection was accomplished.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / mortality. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / surgery. Cholecystectomy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 19666394.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3352165
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6. Hu JB, Sun XN, Xu J, He C: Port site and distant metastases of gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography. World J Gastroenterol; 2008 Nov 7;14(41):6428-31
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  • [Title] Port site and distant metastases of gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography.
  • We report port site and distant metastases of unsuspected gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography (PET) in two patients.
  • Unsuspected gallbladder cancer was discovered with histological result of well-differentiated squamous cell carcinoma of the gallbladder infiltrating the entire wall.
  • A PET scan using F-18-fluorodeoxyglucose (FDG-PET) before radical resection revealed residual tumor in the gallbladder fossa and recurrence at port site and metastases in bilateral hilar lymph nodes.
  • Patient 2, a 69-year-old woman underwent laparoscopic cholecystectomy more than one year ago with pathologically confirmed unsuspected adenosquamous carcinoma of stage pT1b.
  • Excisional biopsy of the nodule revealed adenosquamous carcinoma.
  • This report is followed by a discussion about the utility of FDG-PET in the gallbladder cancer.
  • [MeSH-major] Carcinoma, Adenosquamous / radionuclide imaging. Carcinoma, Squamous Cell / radionuclide imaging. Cholecystectomy, Laparoscopic / adverse effects. Gallbladder Neoplasms / radionuclide imaging. Incidental Findings. Liver Neoplasms / radionuclide imaging. Neoplasm Seeding. Positron-Emission Tomography

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  • (PMID = 19009666.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2766132
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7. Lahmar A, Abid SB, Arfa MN, Bayar R, Khalfallah MT, Mzabi-Regaya S: Metachronous cancer of gallbladder and pancreas with pancreatobiliary maljunction. World J Gastrointest Surg; 2010 Apr 27;2(4):143-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous cancer of gallbladder and pancreas with pancreatobiliary maljunction.
  • It is well known that pancreaticobiliary maljunction is frequently associated with carcinoma of thebiliary tract.
  • We report a case of metachronous cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction and cystic dilatation of common bile duct in a 68-year-old Tunisian woman who underwent a cholecystectomy for acute cholecystitis.
  • The pancreatic tumor was an adenosquamous carcinoma.
  • Pancreaticobiliary maljunction allows for pancreatobiliary or biliopancreatic reflux which may induce biliary tract carcinoma.
  • The association with pancreatic carcinoma remains rare.

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  • (PMID = 21160863.001).
  • [ISSN] 1948-9366
  • [Journal-full-title] World journal of gastrointestinal surgery
  • [ISO-abbreviation] World J Gastrointest Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999228
  • [Keywords] NOTNLM ; Gallbladder cancer / Pancreatic cancer / Pancreaticobiliary maljunction
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8. Fujita T, Fukuda K, Ohmura Y, Nishi H, Mano M, Komatsubara S, Doihara H, Shimizu N: Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection. J Hepatobiliary Pancreat Surg; 2005;12(2):147-50
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  • [Title] Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection.
  • Patients with adenosquamous carcinoma of the gallbladder tend to present with a bulky tumor that frequently displays involvement with adjacent organs, and diagnosis is usually made at an advanced stage.
  • This may contribute to the poor prognosis of patients with adenosquamous carcinoma of the gallbladder compared to patients with adenocarcinoma.
  • We present herein a patient with advanced adenosquamous carcinoma of the gallbladder who is doing well with no evidence of recurrence more than 5 years after radical resection.
  • On admission, abdominal ultrasonography and computed tomography revealed an irregularly shaped solid mass extending from the fundus of the gallbladder, and invasion of the stomach was strongly suspected.
  • Gallbladder carcinoma was diagnosed, and radical resection, including partial gastrectomy, was performed.
  • Histopathologically, adenosquamous carcinoma was diagnosed, and it was graded as si, hinf0, binf0, pv0, a0, t4, n0, and stage IVa.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Gallbladder Neoplasms / surgery

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  • (PMID = 15868080.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Akcali Z, Ozyilkan O, Sakalli H, Bal N, Noyan T: Gallbladder adenosquamous cell carcinoma: report of two cases. Acta Gastroenterol Belg; 2005 Oct-Dec;68(4):440-2
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  • [Title] Gallbladder adenosquamous cell carcinoma: report of two cases.
  • Adenocarcinoma is the usual histological presentation of the very rare gallbladder carcinoma.
  • Adenosquamous cell carcinoma accounts for less than 3.5% of gallbladder carcinomas, and is characterised by invasive growth, a reduced tendency for lymph node metastasis, an increased tendency for hepatic infiltration or liver metastasis, and a poorer prognosis than adenocarcinoma.
  • Adenosquamous carcinoma of the gallbladder was diagnosed on the post-operative pathological specimen.
  • Abdominal computed tomography (CT) imaging showed marked thickening of the gallbladder with direct extension of a mass into the left liver lobe.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / surgery. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery

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  • (PMID = 16432998.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; U3P01618RT / Fluorouracil
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10. Chan KM, Yu MC, Lee WC, Jan YY, Chen MF: Adenosquamous/squamous cell carcinoma of the gallbladder. J Surg Oncol; 2007 Feb 1;95(2):129-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous/squamous cell carcinoma of the gallbladder.
  • BACKGROUND AND OBJECTIVES: Adenosquamous/squamous cell carcinoma is a rare histopathologic subtype of gallbladder malignancy.
  • METHODS: All patients with gallbladder carcinoma were retrospectively reviewed.
  • Patients with a histopathologic subtype of either adenosquamous (n = 12) or squamous cell (n = 2) carcinoma were categorized to group I, and patients with adenocarcinoma were categorized to group II.
  • CONCLUSIONS: Patients with adenosquamous/squamous cell carcinoma of the gallbladder were generally similar to those with adenocarcinoma in clinical characteristics, but had a tendency for liver infiltration.
  • Although the two histopathologic subtypes of the gallbladder carcinoma had similar poor outcomes, better survival could be obtained by performing curative resection for these patients.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / surgery. Gallbladder Neoplasms / surgery

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17262729.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Mingoli A, Brachini G, Petroni R, Antoniozzi A, Cavaliere F, Simonelli L, Chirletti P, Modini C: Squamous and adenosquamous cell carcinomas of the gallbladder. J Exp Clin Cancer Res; 2005 Mar;24(1):143-50
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  • [Title] Squamous and adenosquamous cell carcinomas of the gallbladder.
  • Squamous and adenosquamous cell carcinomas (ASC and SCC) are rare subtypes of gallbladder cancer, traditionally considered more aggressive and with a poorer prognosis than adenocarcinoma.
  • We report about two patients affected by an advanced squamous cell carcinoma of the gallbladder.
  • Both had a large tumour in the gallbladder fossa region with infiltration of the liver.
  • Natural history, clinical findings, prognosis and outcome of this rare gallbladder tumour are discussed on the basis of a review of the English literature.
  • In conclusion, an aggressive and radical surgical treatment of advanced squamous and adenosquamous cell gallbladder carcinomas seems to be indicated for their low proclivity to distant spreading.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Carcinoma, Squamous Cell / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 15943044.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 50
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12. Akatsu T, Kameyama K, Kawachi S, Tanabe M, Aiura K, Wakabayashi G, Ueda M, Shimazu M, Kitajima M: Gallbladder carcinoma with osteoclast-like giant cells. J Gastroenterol; 2006 Jan;41(1):83-7
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  • [Title] Gallbladder carcinoma with osteoclast-like giant cells.
  • Occurrence in the gallbladder is extremely rare, with only one previous case.
  • We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs.
  • A 72-year-old woman presented with postprandial abdominal pain and was found to have a mass in the body of the gallbladder with direct liver invasion.
  • Histological examination showed an adenosquamous carcinoma with an infiltrate of benign OGCs.
  • This case adds to a small body of literature on gallbladder carcinoma with OGCs.
  • Further studies are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma) with those cells.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Gallbladder Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Prognosis

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  • (PMID = 16501862.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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13. Wu W, Pan C, Yu H, Gong H, Wang Y: Heparanase expression in gallbladder carcinoma and its correlation to prognosis. J Gastroenterol Hepatol; 2008 Mar;23(3):491-7
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  • [Title] Heparanase expression in gallbladder carcinoma and its correlation to prognosis.
  • The present study was to analyze the expression of and explore the prognostic value of heparanase and two important transcriptional factors, namely hypoxia-inducible factor-1alpha (HIF-1alpha) and nuclear transcriptional factor kappa B p65 (NF-kappaB p65) in gallbladder cancer.
  • METHODS: Heparanase, HIF-1alpha and NF-kappaB p65 protein levels in 38 patients with gallbladder carcinoma were detected by immunohistochemistry and analyzed for clinicopathological significance.
  • CONCLUSION: Heparanase and HIF-1alpha are frequently expressed in gallbladder carcinoma and are associated with decreased survival.
  • High expression of heparanase, combined with NF-kappaB p65, may contribute to the highly invasive and metastatic behavior of gallbladder carcinoma.
  • [MeSH-major] Adenocarcinoma / enzymology. Carcinoma, Adenosquamous / enzymology. Gallbladder Neoplasms / enzymology. Glucuronidase / analysis

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  • [CommentIn] J Gastroenterol Hepatol. 2008 Mar;23(3):343-4 [18318817.001]
  • (PMID = 17524042.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Transcription Factor RelA; EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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14. Gold DG, Miller RC, Haddock MG, Gunderson LL, Quevedo F, Donohue JH, Bhatia S, Nagorney DM: Adjuvant therapy for gallbladder carcinoma: the Mayo Clinic Experience. Int J Radiat Oncol Biol Phys; 2009 Sep 1;75(1):150-5
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  • [Title] Adjuvant therapy for gallbladder carcinoma: the Mayo Clinic Experience.
  • PURPOSE: To analyze the effect of adjuvant chemoradiotherapy on gallbladder carcinoma.
  • METHODS AND MATERIALS: We retrospectively reviewed the records from consecutive patients who underwent R0 resection of gallbladder carcinoma between January 1, 1985, and December 31, 2004.
  • CONCLUSION: After adjusting for the stage parameters and histologic findings, our data suggest that adjuvant chemoradiotherapy might improve OS for patients with gallbladder cancer.
  • [MeSH-major] Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / radiotherapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / radiotherapy. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Analysis of Variance. Carcinoma, Adenosquamous / drug therapy. Carcinoma, Adenosquamous / mortality. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiotherapy. Carcinoma, Adenosquamous / surgery. Chemotherapy, Adjuvant. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 19297105.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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15. Ren G, Yu G, Liu LW, Ma L: [Expressions of Ep-CAM and cyclin D1 and their clinical significance in gallbladder carcinoma]. Zhonghua Zhong Liu Za Zhi; 2009 Nov;31(11):841-4
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  • [Title] [Expressions of Ep-CAM and cyclin D1 and their clinical significance in gallbladder carcinoma].
  • OBJECTIVE: To investigate the expressions of Ep-CAM and cyclin D1 and their correlation with the clinicopathological factors and prognosis in gallbladder carcinoma.
  • METHODS: Ep-CAM and cyclin D1 expressions were detected by PV6000 immunohistochemical staining in 60 gallbladder carcinoma and 15 para-cancerous mucosa specimens.
  • CONCLUSION: Ep-CAM or cyclin D1 expression is a unfavorable prognostic factor in gallbladder carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Antigens, Neoplasm / metabolism. Cell Adhesion Molecules / metabolism. Cyclin D1 / metabolism. Gallbladder Neoplasms / metabolism
  • [MeSH-minor] Aged. Carcinoma, Adenosquamous / metabolism. Carcinoma, Adenosquamous / pathology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Cell Differentiation. Female. Humans. Male. Middle Aged. Neoplasm Staging. Survival Rate

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  • (PMID = 20137349.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CCND1 protein, human; 0 / Cell Adhesion Molecules; 0 / tumor-associated antigen GA733; 136601-57-5 / Cyclin D1
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16. Tanaka T, Sekimura A, Tanaka H, Tonegawa K, Ogawa K, Haneda H: [Gallbladder metastasis of large cell lung cancer]. Kyobu Geka; 2009 Nov;62(12):1069-72
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  • [Title] [Gallbladder metastasis of large cell lung cancer].
  • A man, who received right upper lobectomy of the lung due to stage IIB large cell carcinoma 7 and half years ago, visited our hospital complaining of right upper abdominal pain.
  • Computed tomography (CT) revealed gallbladder tumor and extended resection of the gallbladder was performed.
  • Pathological diagnosis was adenosquamous cell carcinoma After 1 year and 4 months later, left adrenal gland tumor was found by CT scan, and the surgery was conducted.
  • By reevaluation of pathology of the gallbladder, the tumor was found to have similar component of resected lung cancer, suggesting the possibility of the tumor to be metastatic.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Gallbladder Neoplasms / secondary. Lung Neoplasms / pathology

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  • (PMID = 19894573.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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17. Park HS, Lim JY, Yoon DS, Park JS, Lee DK, Lee SJ, Choi HJ, Song SY, Lee WJ, Cho JY: Outcome of adjuvant therapy for gallbladder cancer. Oncology; 2010;79(3-4):168-73
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  • [Title] Outcome of adjuvant therapy for gallbladder cancer.
  • OBJECTIVES: The aim of this study was to evaluate the outcome of adjuvant therapy on the overall survival (OS) and disease-free survival (DFS) after curative resection (RO) of patients with TNM stage II gallbladder (GB) cancer.
  • [MeSH-major] Adenocarcinoma / therapy. Antineoplastic Agents / therapeutic use. Carcinoma, Adenosquamous / therapy. Carcinoma, Squamous Cell / therapy. Gallbladder Neoplasms / therapy

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21212704.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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18. Tan Y, Meng HP, Wu Q, Wang FQ, Wu HR: [Proteomic study of gallbladder cancer, with special reference on the expression and significance of annexin A3]. Zhonghua Bing Li Xue Za Zhi; 2010 Jun;39(6):382-6
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  • [Title] [Proteomic study of gallbladder cancer, with special reference on the expression and significance of annexin A3].
  • OBJECTIVE: To explore the potential molecular targets for diagnosis and treatment of gallbladder cancer by analyzing and comparing the proteomes expressed in human gallbladder cancer and benign gallbladder tissues.
  • AnnexinA3 expression was examined by streptavidin peroxidase immunohistochemical technique on paraffin-embedded tissue sections from 50 patients of gallbladder cancer and 38 cases of chronic eholecystitis.
  • There were forty six differentially expressed proteins in the tissue samples of gallbladder cancer.
  • The positive expression rates of annexinA3 in gallbladder cancer was significantly higher than that in chronic cholecystitis, and the difference was statistically significant (74.0% vs 21.1%, P < 0.01).
  • In the gallbladder cancer, no correlation was obtained between annexinA3 and age, gender or histologicl type (P > 0.05), but overexpression of annexinA3 correlated significantly with those cases with a lower histological grading (40.0% vs 82.5%, P < 0.05); lymph node or distant metastasis (40.9% vs 100%, P < 0.05); or a shorter survival time after operation (50.0% vs 93.8%, P < 0.05).
  • CONCLUSIONS: Significant discrepancies in protein expression exist among gallbladder cancer and benign gallbladder tissues.
  • AnnexinA3 plays an important role in the initiation and progression of human gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Annexin A3 / metabolism. Gallbladder Neoplasms / metabolism. Gene Expression Profiling
  • [MeSH-minor] Adult. Aged. Carcinoma, Adenosquamous / metabolism. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Cholecystitis / metabolism. Electrophoresis, Gel, Two-Dimensional. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Metastasis. Proteome / metabolism. Proteomics. Survival Rate

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  • (PMID = 21055154.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Proteome; EC 3.1.4.43 / Annexin A3
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19. Kornprat P, Rehak P, Lemmerer M, Gogg-Kamerer M, Langner C: Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma. Virchows Arch; 2005 May;446(5):505-10
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  • [Title] Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma.
  • We investigated TFF1 expression in healthy and inflamed non-neoplastic gallbladder mucosa as well as in gallbladder carcinomas (n=57) and corresponding metastases (n=18), using a tissue microarray technique.
  • In conclusion, TFF1 is expressed in inflamed non-neoplastic gallbladder epithelium and in low stage and low grade gallbladder carcinomas.
  • Thus, TFF1 may be the missing link between gallstones, chronic cholecystitis and gallbladder cancer.
  • [MeSH-major] Carcinoma / chemistry. Cholecystitis / metabolism. Gallbladder Neoplasms / chemistry. Proteins / analysis
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Adenocarcinoma, Clear Cell / chemistry. Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Mucinous / chemistry. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Analysis of Variance. Carcinoma, Adenosquamous / chemistry. Carcinoma, Adenosquamous / pathology. Carcinoma, Papillary / chemistry. Carcinoma, Papillary / pathology. Carcinoma, Signet Ring Cell / chemistry. Carcinoma, Signet Ring Cell / pathology. Chronic Disease. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucous Membrane / chemistry. Neoplasm Metastasis. Neoplasm Staging. Prognosis. Survival Rate. Trefoil Factor-1. Tumor Suppressor Proteins

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  • (PMID = 15821928.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Proteins; 0 / TFF1 protein, human; 0 / Trefoil Factor-1; 0 / Tumor Suppressor Proteins
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20. Lam CM, Yuen AW, Wai AC, Leung RM, Lee AY, Ng KK, Fan ST: Gallbladder cancer presenting with acute cholecystitis: a population-based study. Surg Endosc; 2005 May;19(5):697-701
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  • [Title] Gallbladder cancer presenting with acute cholecystitis: a population-based study.
  • The aim of the present study was to determine the incidence, clinicopathological characteristics, and outcome of patients with gallbladder cancer presenting with acute cholecystitis.
  • METHODS: We performed a retrospective analysis of patients with gallbladder cancer who presented with acute cholecystitis and were treated at the public hospitals in Hong Kong between 1998 and 2002.
  • RESULTS: Among 2,700 patients with acute cholecystitis managed with cholecystectomy (1,347 open and 1,353 LC), 63 patients (2.3%) were found to have gallbladder cancer.
  • CONCLUSIONS: In the ethnic Chinese population of Hong Kong, the incidence of gallbladder cancer presenting with acute cholecystitis is higher than the same finding in patients undergoing elective cholecystectomy for cholelithiasis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Cholecystitis / etiology. Gallbladder Neoplasms / diagnosis
  • [MeSH-minor] Acute Disease. Aged. Aged, 80 and over. Breast Neoplasms. Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / surgery. Carcinoma, Ductal, Breast / secondary. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Cholecystectomy, Laparoscopic. Cholelithiasis / epidemiology. Cholelithiasis / surgery. Comorbidity. Elective Surgical Procedures / statistics & numerical data. Female. Hong Kong / epidemiology. Hospital Mortality. Humans. Incidence. Incidental Findings. Life Tables. Lymphoma / diagnosis. Lymphoma / surgery. Male. Middle Aged. Neoplasm Seeding. Retrospective Studies. Survival Analysis. Survival Rate. Treatment Outcome

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  • (PMID = 15776204.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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21. Ghosh M, Kamma H, Kawamoto T, Koike N, Miwa M, Kapoor VK, Krishnani N, Agrawal S, Ohkohchi N, Todoroki T: MUC 1 core protein as a marker of gallbladder malignancy. Eur J Surg Oncol; 2005 Oct;31(8):891-6
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  • [Title] MUC 1 core protein as a marker of gallbladder malignancy.
  • AIM: The significance of MUC 1 expression in the gallbladder tissues in relation to cancer and non-cancer disease is not well understood.
  • RESULTS: MUC 1 expression is significantly higher (p<0.0001) in gallbladder cancer (69/88) compare to non-cancerous tissue, while, very trace in normal and inflammatory tissues.
  • CONCLUSION: MUC 1 core protein expression rate and pattern are suggesting that MUC 1 core protein would be a marker of malignant transformation of gallbladder epithelium and its depolarized expression would also be a marker of invasion of gallbladder cancer.
  • [MeSH-major] Antigens / analysis. Biomarkers, Tumor / analysis. Gallbladder Neoplasms / pathology. Glycoproteins / analysis. Mucins / analysis
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Antibodies, Monoclonal. Antigens, Neoplasm. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / secondary. Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / secondary. Cell Polarity. Cholecystitis / pathology. Coloring Agents. Connective Tissue / pathology. Gallbladder / pathology. Granuloma / pathology. Humans. Lymphatic Metastasis / pathology. Mucin-1. Mucous Membrane / pathology. Neoplasm Invasiveness. Neoplasm Staging. Serous Membrane / pathology. Xanthomatosis / pathology

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  • (PMID = 15922536.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Glycoproteins; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Mucins
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22. Robledo-Ogazón F, Vargas-Rivas A, Hernández-Ramírez DA, Castellanos-Juárez JC: [Congenital diaphragmatic adult hernia. Case report]. Cir Cir; 2008 Jan-Feb;76(1):61-4
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  • [Transliterated title] Hernia diafragmática congénita en el adulto. Informe de un caso.
  • Diagnosis is incidental or when it becomes symptomatic.
  • Our objective was to offer the general surgeon a differential diagnosis for presence of noncardiac thoracic pain in the adult.
  • This was confirmed by barium esophagogram, upper gastrointestinal endoscopy and abdominal CT scan where porcelain gallbladder was also detected.
  • Primary repair of the diaphragm and cholecystectomy were performed, confirming gallbladder cancer.
  • It is important that the surgeon establishes an etiological diagnosis in order to offer appropriate treatment.
  • CONCLUSIONS: Congenital diaphragmatic hernia in the adult is rarely suspected in the differential diagnosis of noncardiac thoracic pain.
  • The surgeon must keep this in mind, especially in patients of advanced age, even when cardiac and/or gastrointestinal diagnosis is confirmed.
  • [MeSH-minor] Age of Onset. Aged. Carcinoma, Adenosquamous / complications. Carcinoma, Adenosquamous / radiography. Carcinoma, Adenosquamous / surgery. Cholecystectomy. Cholelithiasis / complications. Cholelithiasis / surgery. Cough / etiology. Diagnostic Errors. Dyspepsia / diagnosis. Female. Gallbladder Neoplasms / complications. Gallbladder Neoplasms / radiography. Gallbladder Neoplasms / surgery. Gastroesophageal Reflux / etiology. Heart Diseases / diagnosis. Hernia, Diaphragmatic / complications. Hernia, Diaphragmatic / diagnosis. Hernia, Diaphragmatic / epidemiology. Humans. Incidental Findings. Lung Diseases / diagnosis. Tomography, X-Ray Computed


23. Farah-Klibi F, Ben Rejeb M, Salah RB, Najeh N, Zaouche A, Ben Jilani S, Zermani R: [Adenosquamous cell carcinoma of the gallbladder]. Gastroenterol Clin Biol; 2008 Jun-Jul;32(6-7):632-4
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenosquamous cell carcinoma of the gallbladder].
  • [Transliterated title] Carcinome adénosquameux primitif de la vésicule biliaire.
  • [MeSH-major] Carcinoma, Adenosquamous. Gallbladder Neoplasms

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  • (PMID = 18556164.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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24. Noske A, Pahl S: Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder. Virchows Arch; 2006 Jul;449(1):135-6
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder.
  • [MeSH-major] Bone Neoplasms / secondary. Carcinoma, Adenosquamous / secondary. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / secondary. Gallbladder Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Bone Cancer.
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  • [Cites] Am J Surg Pathol. 2000 Oct;24(10):1424-8 [11023106.001]
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  • (PMID = 16570181.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Dutta U, Poornachandra KS: Heparanase and gallbladder cancer: new insights into understanding tumor growth and invasion. J Gastroenterol Hepatol; 2008 Mar;23(3):343-4
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Heparanase and gallbladder cancer: new insights into understanding tumor growth and invasion.
  • [MeSH-major] Adenocarcinoma / enzymology. Carcinoma, Adenosquamous / enzymology. Gallbladder Neoplasms / enzymology. Glucuronidase / analysis

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  • [CommentOn] J Gastroenterol Hepatol. 2008 Mar;23(3):491-7 [17524042.001]
  • (PMID = 18318817.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Enzyme Inhibitors; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Transcription Factor RelA; EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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