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1. Baydar DE, Kosemehmetoglu K, Akdogan B, Ozen H: Prostatic adenosquamous carcinoma metastasizing to testis. ScientificWorldJournal; 2006;6:2491-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prostatic adenosquamous carcinoma metastasizing to testis.
  • Adenosquamous carcinoma of the prostate is an unusual tumor with poor prognosis.
  • Most arise after hormonal or radiotherapy of conventional prostatic adenocarcinoma.
  • Here, we present a unique case of "de novo prostatic adenosquamous carcinoma with focal sarcomatoid areas" that showed testicular metastasis, detected after scrotal orchiectomy.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / pathology. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / pathology. Testicular Neoplasms / secondary

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  • (PMID = 17619723.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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2. Passon P, Tessitori G, Lombardo M, Callea S, Poli P: Long-surviving case of adenosquamous carcinoma of the larynx: case report and review of literature. Acta Otorhinolaryngol Ital; 2005 Oct;25(5):301-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-surviving case of adenosquamous carcinoma of the larynx: case report and review of literature.
  • A singularly long-surviving (15 years) disease-free case of a stage II adenosquamous carcinoma of the larynx is described.
  • A review of the literature reveals that prognosis of this aggressive malignant neoplasm is poor (mean 2-3 years free of disease) on account of local recurrences, early cervical lymph node metastasis and distant dissemination.
  • [MeSH-major] Carcinoma, Adenosquamous / mortality. Laryngeal Neoplasms / mortality

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  • (PMID = 16602330.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2639909
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3. Okabayashi T, Hanazaki K: Surgical outcome of adenosquamous carcinoma of the pancreas. World J Gastroenterol; 2008 Nov 28;14(44):6765-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcome of adenosquamous carcinoma of the pancreas.
  • Adenosquamous carcinoma is rare, accounting for 3%-4% of all pancreatic carcinoma cases.
  • These tumors are characterized by the presence of variable proportions of mucin-producing glandular elements and squamous components, the latter of which should account for at least 30% of the tumor tissue.
  • Recently, several reports have described cases of adenosquamous carcinoma of the pancreas.
  • However, as the number of patients who undergo resection at a single institute is limited, large studies describing the clinicopathological features, therapeutic management, and surgical outcome for adenosquamous carcinoma of the pancreas are lacking.
  • We performed a literature review of English articles retrieved from Medline using the keywords 'pancreas' and 'adenosquamous carcinoma'.
  • Our subsequent review of the literature revealed that optimal adjuvant chemotherapy and/or radiotherapy regimens for adenosquamous carcinoma of the pancreas have not been established, and that curative surgical resection offers the only chance for long-term survival.
  • Unfortunately, the prognosis of the 39 patients who underwent pancreatic resection for adenosquamous carcinoma was very poor, with a 3-year overall survival rate of 14.0% and a median survival time of 6.8 mo.
  • Since the postoperative prognosis of adenosquamous carcinoma of the pancreas is currently worse than that of pancreatic adenocarcinoma, new adjuvant chemotherapies and/or radiation techniques should be investigated as they may prove indispensible to the improvement of surgical outcomes.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery

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  • (PMID = 19058301.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial; Review
  • [Publication-country] China
  • [Number-of-references] 40
  • [Other-IDs] NLM/ PMC2773870
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4. Huang SF, Chuang WY, Cheng SD, Hsin LJ, Lee LY, Kao HK: A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma--a case report with EGFR copy number analysis. World J Surg Oncol; 2010;8:92
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  • [Title] A colliding maxillary sinus cancer of adenosquamous carcinoma and small cell neuroendocrine carcinoma--a case report with EGFR copy number analysis.
  • BACKGROUND: Small cell neuroendocrine carcinoma (SNEC) of maxillary sinus is a rare and aggressive malignancy.
  • A tumor with squamous cell carcinoma, adenocarcinoma and SNEC co-existence is extremely rare.
  • CASE PRESENTATION: We present a colliding tumor of squamous cell, adenocarcinoma and SNEC in maxillary sinus.
  • The clinical features, diagnosis and EGFR flourescence in situ hybridization (FISH) study are presented.
  • The pathology revealed a malignant tumor composed of squamous cell carcinoma, adenocarcinoma and SNEC components.
  • CONCLUSION: A colliding tumor of squamous cell, adenocarcinoma and neuroendocrine carcinoma in maxillary sinus was aggressive in behavior and the treatment response was poor due to the complexity of tumor.
  • [MeSH-major] Carcinoma, Neuroendocrine / genetics. Carcinoma, Small Cell / genetics. DNA, Neoplasm / genetics. Maxillary Sinus Neoplasms / genetics. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Follow-Up Studies. Humans. In Situ Hybridization, Fluorescence. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 20961443.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Other-IDs] NLM/ PMC2984401
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5. Krivokapic Z, Dimitrijevic I, Barisic G, Markovic V, Krstic M: Adenosquamous carcinoma arising within a retrorectal tailgut cyst: report of a case. World J Gastroenterol; 2005 Oct 21;11(39):6225-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma arising within a retrorectal tailgut cyst: report of a case.
  • We report a patient with adenosquamous carcinoma arising within RCH, who underwent complete resection of the cyst through anterior laparotomy, and reached complete (recurrence-free for 14 mo, so far) functional recovery.
  • The mentioned period between diagnosis and surgical treatment suggests that RCH, given enough time, can develop malignant degeneration, and should be resected at the time of diagnosis.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Cysts / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16273657.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436647
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6. Fu JM, McCalmont T, Yu SS: Adenosquamous carcinoma of the skin: a case series. Arch Dermatol; 2009 Oct;145(10):1152-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the skin: a case series.
  • BACKGROUND: Adenosquamous carcinoma is an uncommon cutaneous malignant neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive clinical behavior.
  • OBSERVATIONS: Of 27 patients diagnosed as having adenosquamous carcinoma, 19 were men and 5 were immunosuppressed.
  • Squamous and glandular differentiation was characteristic.
  • CONCLUSIONS: Adenosquamous carcinoma is best considered as a locally aggressive high-risk subtype of cutaneous squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / epidemiology. Skin Neoplasms / pathology

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  • (PMID = 19841403.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Fujiwara N, Baba H, Nakamura H, Kuwabara H, Tamai S, Nakajima K, Gosek N: [A case of adenosquamous carcinoma of the liver]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2392-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of adenosquamous carcinoma of the liver].
  • Pathological diagnosis of the resected specimen was adenosquamous carcinoma of the liver.
  • Adenosquamous carcinoma of the liver is very rare and its prognosis is very poor due to local recurrence and metastasis to the lymph node.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Liver Neoplasms / pathology

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  • (PMID = 20037433.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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8. Damadoğlu E, Aybatli A, Yalçinsoy M, Tahaoğlu C, Atasalihi A, Akkaya E, Yilmaz A: [Adenosquamous carcinoma of the lung (an analysis of 13 cases)]. Tuberk Toraks; 2005;53(2):161-6
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  • [Title] [Adenosquamous carcinoma of the lung (an analysis of 13 cases)].
  • Adenosquamous carcinoma of the lung is a rare disease.
  • In this study, we retrospectively evaluated 13 patients with adenosquamous carcinoma of the lung diagnosed at our center between January 2001 and May 2004.
  • Preoperative pathological diagnosis was squamous cell carcinoma in eight patients, non-small cell lung carcinoma in four patients and adenocarcinoma in one patient.
  • Five patients died of disease within 3 and 21 months.
  • [MeSH-major] Carcinoma, Adenosquamous / epidemiology. Lung Neoplasms / epidemiology

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  • (PMID = 16100653.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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9. Trikudanathan G, Dasanu CA: Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity. South Med J; 2010 Sep;103(9):903-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity.
  • Among exocrine pancreatic tumors, adenosquamous carcinoma (ASC) is a rare, aggressive subtype with a worse prognosis and a higher potential for metastases compared to its more conventional glandular counterpart, adenocarcinoma.
  • The disease distribution shows an approximately 1:1 male/female ratio and a median survival of circa five months.
  • Humoral hypercalcemia of malignancy has also been described with ASC of the pancreas, likely as a result of PTHrP production by the squamous component of the tumor.
  • Similar to the therapeutics of pancreatic adenocarcinoma, adjuvant chemotherapy or chemoradiotherapy is currently indicated for resectable ASC of the pancreas, while gemcitabine or gemcitabine combinations are used for a more advanced disease.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy
  • [MeSH-minor] Abdominal Pain / etiology. Biomarkers, Tumor. Chemotherapy, Adjuvant. Diagnostic Imaging. Genetic Predisposition to Disease. Humans. Jaundice / etiology. Mutation. Necrosis. Palliative Care. Pancreas / pathology. Pancreatectomy. Risk Factors. Survival Analysis. Weight Loss

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  • (PMID = 20697320.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 43
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10. Terada T: Adenosquamous carcinoma in a congenital choledochal cyst associated with pancreatico-biliary maljunction. Pathol Int; 2009 Jul;59(7):482-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma in a congenital choledochal cyst associated with pancreatico-biliary maljunction.
  • Congenital choledochal cyst is occasionally complicated by carcinomatous transformation, mostly adenocarcinoma.
  • Adenosquamous carcinoma arising in a congenital choledochal cyst is very rare.
  • The author herein reports an adenosquamous carcinoma arising in congenital choledochal cyst associated with pancreatico-biliary maljunction.
  • Because clinical cytology of bile indicated malignant cells, pancreatico-duodenectomy, cholecystectomy, and resection of the choledochal cyst were performed.
  • Histologically, the lesion was composed of a squamous cell carcinoma element and an adenocarcinoma element; a gradual transition was recognized between the two.
  • The squamous cell carcinoma element contained microcytic cells with mucins.
  • On immunohistochemistry the adenocarcinoma element and microcytic cells were positive for CEA, but the squamous cell carcinoma element was negative for CEA.
  • Ki-67 labeling was 53% in the adenocarcinoma element and 48% in the squamous cell carcinoma element. p53 protein was negative in both elements.
  • The present case is the second case of adenosquamous carcinoma arising in congenital choledochal cyst in the English-language literature.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Carcinoma, Adenosquamous / pathology. Choledochal Cyst / pathology

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  • (PMID = 19563412.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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11. Ho BC, Tan HW, Lee VK, Tan PH: Preoperative and intraoperative diagnosis of low-grade adenosquamous carcinoma of the breast: potential diagnostic pitfalls. Histopathology; 2006 Dec;49(6):603-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative and intraoperative diagnosis of low-grade adenosquamous carcinoma of the breast: potential diagnostic pitfalls.
  • AIMS: Low-grade adenosquamous carcinoma (LGAC), a rare variant of metaplastic breast cancer, may mimic benign or other low-grade malignant lesions histologically.
  • The fourth case entailed a frozen section specimen, for which definitive diagnosis was deferred to paraffins.
  • The patients remained well with no evidence of recurrent disease to date.
  • CONCLUSIONS: When limited material, in the form of needle aspirates, core biopsy specimens or frozen sections, is submitted for histology, making a diagnosis of LGAC is not only challenging, but may be impossible.
  • In difficult cases, careful pathological assessment, clinicopathological correlation and follow-up or complete excision biopsy may prove invaluable in establishing a definitive diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Carcinoma, Adenosquamous / diagnosis. Diagnostic Errors / prevention & control
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Disease-Free Survival. Female. Frozen Sections. Humans. Immunoenzyme Techniques. Intraoperative Period. Metaplasia. Middle Aged. Preoperative Care

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  • (PMID = 17163845.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. McCormack M, Ledermann JA, Hall-Craggs MA, Symonds RP, Warwick V, Simonds H, Fernando I, Hackshaw A: A phase II study of weekly neoadjuvant chemotherapy followed by radical chemoradiation for locally advanced cervical cancer. J Clin Oncol; 2009 May 20;27(15_suppl):5586

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Baseline characteristics were: median age at diagnosis 43 yrs (23-71); 74% squamous-, 20% adeno- and 6% adenosquamous carcinomas; FIGO stage IB2 (11%), II (50%), III (33%), IV (6%).

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  • (PMID = 27962391.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Ishibashi H, Akamatsu H, Kojima K, Usui H, Akashi T, Sunamori M: Good syndrome with thymic adenosquamous carcinoma--report of a case. Ann Thorac Cardiovasc Surg; 2007 Feb;13(1):50-2
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  • [Title] Good syndrome with thymic adenosquamous carcinoma--report of a case.
  • A 68-year-old man with recurrent bilateral severe pneumonia and invasive thymic carcinoma was admitted to our hospital.
  • The tumor was mainly composed of type C, adenosquamous carcinoma, and found to have a small area of types B2 and B3 thymoma.
  • History and laboratory findings were compatible with the diagnosis of Good syndrome.
  • Although there are some reports of thymic carcinoma arising from thymoma, this is the first report of co-existence of adenosquamous carcinomas and thymoma with Good syndrome as far as reviewed articles.
  • Thymic carcinoma with severe infection should be examined carefully for co-existence of thymoma, and co-existence of thymoma and thymic carcinoma suggests a close histogenetic relationship between the 2 tumors.
  • [MeSH-major] Carcinoma, Adenosquamous. Paraneoplastic Syndromes. Thymoma. Thymus Neoplasms

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  • (PMID = 17392673.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Nadeau DP, Shick PC, Lindsay R: Adenosquamous carcinoma of the lateral oropharyngeal wall. Ear Nose Throat J; 2010 Nov;89(11):E18-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the lateral oropharyngeal wall.
  • Adenosquamous carcinoma of the head and neck is a rare and aggressive tumor, with fewer than 100 cases reported in the world literature to date.
  • We report a case of adenosquamous carcinoma of the oral pharynx arising as a second primary malignancy in a patient being treated for primary gastric MALT (mucosa-associated lymphoid tissue) lymphoma.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Neoplasms, Second Primary / pathology. Oropharyngeal Neoplasms / pathology
  • [MeSH-minor] Humans. Lymphoma, B-Cell, Marginal Zone / pathology

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  • (PMID = 21086267.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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15. Karateke A, Gurbuz A, Kir G, Haliloglu B, Kabaca C, Devranoglu B, Yakut Y: Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:379-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature.
  • A 40-year-old woman with mucoepidermoid variant of adenosquamous carcinoma arising in dermoid cyst in left ovary is presented.
  • The disease recurred in postoperative 12th month.
  • To our best knowledge, this is 12th case of adenosquamous carcinoma in dermoid cyst and third case of mucoepidermoid variant of adenosquamous carcinoma in the literature.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma, Adenosquamous / pathology. Carcinoma, Mucoepidermoid / pathology. Dermoid Cyst / complications. Ovarian Neoplasms / pathology

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  • (PMID = 16515628.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 20
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16. Geyer FC, Lambros MB, Natrajan R, Mehta R, Mackay A, Savage K, Parry S, Ashworth A, Badve S, Reis-Filho JS: Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast. Mod Pathol; 2010 Jul;23(7):951-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast.
  • Breast adenosquamous carcinomas are rare tumours characterized by well-developed gland formation intimately admixed with solid nests of squamous cells immersed in a highly cellular spindle cell stroma.
  • Here we studied five cases of adenosquamous carcinomas to determine their genetic profiles and to investigate whether the spindle cell component of these cancers could at least in part stem from the glandular/epithelial components.
  • Five adenosquamous carcinomas of the breast were subjected to (1) immunohistochemical analysis, (2) microdissection and genetic analysis with a high-resolution microarray comparative genomic hybridization platform, and (3) chromogenic in situ hybridization.
  • In conclusion, breast adenosquamous carcinomas are triple-negative cancers that express 'basal' keratins.
  • Some of the spindle cells in adenosquamous carcinomas are derived from the epithelial component, suggesting that adenosquamous carcinomas may also be part of the group of metaplastic breast carcinomas with spindle cell metaplastic elements.
  • [MeSH-major] Breast Neoplasms / genetics. Breast Neoplasms / pathology. Carcinoma, Adenosquamous / genetics. Carcinoma, Adenosquamous / pathology

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  • (PMID = 20453835.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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17. Okamura Y, Sugimoto H, Fujii T, Nomoto S, Takeda S, Nakao A: Adenosquamous carcinoma arising in an intraductal papillary mucinous neoplasm of the pancreas. Pancreas; 2010 Aug;39(6):945-7
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  • [Title] Adenosquamous carcinoma arising in an intraductal papillary mucinous neoplasm of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Carcinoma, Adenosquamous / diagnosis. Carcinoma, Pancreatic Ductal / complications. Carcinoma, Papillary / complications. Pancreatic Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Pancreas / pathology

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  • (PMID = 20664487.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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18. Kang SM, Kang HJ, Shin JH, Kim H, Shin DH, Kim SK, Kim JH, Chung KY, Kim SK, Chang J: Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung. Cancer; 2007 Feb 1;109(3):581-7
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  • [Title] Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung.
  • BACKGROUND: Adenosquamous carcinoma of the lung is composed of adenocarcinomatous and squamous cell carcinomatous components.
  • The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung.
  • Attempts to investigate the EGFR mutation status in each component of adenosquamous carcinoma and to characterize the patients according to mutation status may help to understand the histogenesis of adenosquamous carcinoma.
  • METHODS: The mutation status of EGFR kinase domain from exon 18 to 21 was investigated in 25 Korean patients with adenosquamous carcinoma by polymerase chain reaction-single strand conformation polymorphism using the tissues of each component from the adenosquamous carcinoma tumor.
  • Identical EGFR mutations in both components of adenosquamous carcinoma were confirmed by nucleotide sequencing.
  • CONCLUSIONS: The frequency of EGFR mutation and clinicopathologic characteristics of the EGFR mutants in adenosquamous carcinoma are similar to those of Asian patients with adenocarcinomas.
  • Identical EGFR mutations in both components suggest the possibility of monoclonality in the histogenesis of adenosquamous carcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Carcinoma, Adenosquamous / genetics. Carcinoma, Non-Small-Cell Lung / genetics. Carcinoma, Squamous Cell / genetics. Lung Neoplasms / genetics. Mutation / genetics. Receptor, Epidermal Growth Factor / genetics

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  • [Copyright] (c) 2007 American Cancer Society.
  • (PMID = 17186532.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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19. He YT, Wang XJ, Gong J, Chen N, Zhou Q: Primary adenosquamous carcinoma of the jejunum. Pathol Int; 2005 Sep;55(9):590-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adenosquamous carcinoma of the jejunum.
  • Adenosquamous carcinomas of the small intestine are extremely rare, with only three documented jejunal and three ileal cases being reported in the English-language medical literature.
  • Presented herein is a case of primary jejunal adenosquamous carcinoma in an 80-year-old woman.
  • The jejunal carcinoma consisted predominantly of a squamous component throughout the tumor but peritoneal nodules carrying metastases from the adenocarcinoma element were noted, making it the first case of jejunal adenosquamous carcinoma with metastases from the adenocarcinoma component.
  • The finding that metastases could arise from the minor component of a jejunal adenosquamous carcinoma indicates that an accurate diagnosis must be based upon thorough examination of both the primary and the metastases, not just mesenteric nodule biopsy alone.
  • Histological foci of closely intermingled squamous and glandular components with apparent morphological transition were noted, indicating the pathogenetic possibility that the squamous component might arise by transformation from the glandular element.
  • The squamous component was strongly positive with immunostaining for p63 (nuclear staining) and for cytokeratin 10/13 (cytoplasmic staining), while the adenocarcinoma element was negative.
  • The immunohistochemical results suggest that p63 and cytokeratin 10/13 might be useful in identifying squamous differentiation in jejunal carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / secondary. Jejunal Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cell Nucleus / chemistry. Cell Nucleus / pathology. Cytoplasm / chemistry. Cytoplasm / pathology. DNA-Binding Proteins. Fatal Outcome. Female. Genes, Tumor Suppressor. Humans. Immunoenzyme Techniques. Keratins / analysis. Phosphoproteins / analysis. Trans-Activators / analysis. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16143036.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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20. Agrawal A, Saha S, Ellis IO, Bello AM: Adenosquamous carcinoma of breast in a 19 years old woman: a case report. World J Surg Oncol; 2010;8:44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of breast in a 19 years old woman: a case report.
  • BACKGROUND: Adenosquamous carcinoma of the breast is a rare form of metaplastic breast carcinoma.
  • Adenosquamous carcinoma was diagnosed on wide local excision and patient underwent skin-sparing mastectomy with Latissimus dorsi flap reconstruction.
  • CONCLUSIONS: Adenosquamous carcinoma of the breast is a rare form of metaplastic breast carcinoma.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Adenosquamous / pathology

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  • [Cites] Histopathology. 2000 Mar;36(3):203-9 [10692021.001]
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  • (PMID = 20507552.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2887870
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21. Kuroda N, Oonishi K, Inoue K, Ohara M, Mizuno K, Lee GH: Lymphoepithelioma-like carcinoma of the stomach associated with adenosquamous carcinoma. Med Mol Morphol; 2010 Sep;43(3):170-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymphoepithelioma-like carcinoma of the stomach associated with adenosquamous carcinoma.
  • Lymphoepithelioma-like carcinoma and adenosquamous carcinoma of the stomach are relatively rare tumors.
  • To date, there are no reports on lymphoepithelioma-like carcinoma of the stomach associated with adenosquamous carcinoma.
  • Histological examination of the gastric tumor showed the coexistence of lymphoepithelioma-like carcinoma and adenosquamous carcinoma.
  • Neoplastic cells of the latter were immunoreactive for p63 and keratin 903, and Alcian blue stain detected acid mucin in glandular lumens.
  • This pattern resembled mucoepidermoid carcinoma in the salivary gland.
  • Finally, this is the first case of gastric lymphoepithelioma-like carcinoma associated with adenosquamous carcinoma, and clinicians and pathologists should recognize the presence of such a tumor.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Lymphoma / pathology. Stomach Neoplasms / pathology

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  • (PMID = 20857266.001).
  • [ISSN] 1860-1499
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA-Binding Proteins; 0 / Ribosomal Proteins; 135844-68-7 / RPL22 protein, human
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22. Zainuddin MA, Hong TY: Primary renal adenosquamous carcinoma. Urol Ann; 2010 Sep;2(3):122-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary renal adenosquamous carcinoma.
  • A case of renal adenosquamous carcinoma is presented.
  • The fact that the urothelium has no glandular or squamous structures makes the pathogenesis of this tumor unique.
  • The process is assumed to begin with urothelial metaplasia resulting from chronic irritation leading to dysplasia and subsequently squamous and glandular differentiation.

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  • (PMID = 20981201.001).
  • [ISSN] 0974-7834
  • [Journal-full-title] Urology annals
  • [ISO-abbreviation] Urol Ann
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2955228
  • [Keywords] NOTNLM ; Adenosquamous carcinoma / metaplasia / renal
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23. Ko CJ, Leffell DJ, McNiff JM: Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. J Cutan Pathol; 2009 Apr;36(4):448-52
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  • [Title] Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining.
  • Adenosquamous carcinoma, a rare tumor of the skin with few reported cases in the literature, has not been studied with p63, cytokeratin 5/6 and cytokeratin 7.
  • Histologically, the tumors showed superficial, atypical islands of keratinocytes in close association with islands displaying glandular differentiation.
  • Clinically, lesions favored the head and trunk, and a subset of cases showed aggressive behavior.
  • Recognition of adenosquamous carcinoma is important for appropriate therapy, and stains for p63 and cytokeratin 5/6 may be helpful in ruling out metastatic adenocarcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Keratin-5 / biosynthesis. Keratin-6 / biosynthesis. Membrane Proteins / biosynthesis. Skin Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Keratin-7 / biosynthesis. Male. Middle Aged

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  • (PMID = 19278431.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Keratin-5; 0 / Keratin-6; 0 / Keratin-7; 0 / Membrane Proteins
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24. Egilmez T, Bal N, Guvel S, Kilinc F, Ozkardes H: Adenosquamous carcinoma of the prostate. Int J Urol; 2005 Mar;12(3):319-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the prostate.
  • Adenosquamous carcinoma of the prostate is an unusual histological variant of prostate cancer.
  • The stimulus for the development of the squamous metaplastic cells had been thought to be related to hormone and/or radiation therapy.
  • This report presents a case of adenosquamous carcinoma of the prostate with abscence of previous hormone or radiation therapy.
  • The case showed negative prostate-specific antigen and high molecular weight cytokeratin staining of the adenocarcinoma component, and negative prostate-specific antigen and positive high molecular weight cytokeratin staining of the squamous cell carcinoma component.
  • The adenocarcinoma component stained intraluminally with periodic acid schiff.
  • The staining features and the distinct localizations of the components with intermingling, but no transition, are against the collision-type tumor theory and support the theory that the adenocarcinoma and squamous components arise de novo from pluripotent stem cells.
  • The patient had a rapid downhill clinical course and died 3 weeks after the diagnosis was made.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Prostatic Neoplasms / diagnosis

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  • (PMID = 15828965.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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25. Ogura K, Ishi K, Matsumoto T, Kina K, Nojima M, Suda K: Human papillomavirus localization in cervical adenocarcinoma and adenosquamous carcinoma using in situ polymerase chain reaction: review of the literature of human papillomavirus detection in these carcinomas. Pathol Int; 2006 Jun;56(6):301-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus localization in cervical adenocarcinoma and adenosquamous carcinoma using in situ polymerase chain reaction: review of the literature of human papillomavirus detection in these carcinomas.
  • Many studies have suggested that human papillomavirus (HPV) infection plays an important role in the carcinogenesis of the cervical adenocarcinoma.
  • However, the prevalence of HPV infection in cervical adenocarcinoma and adenosquamous carcinoma varies among the studies.
  • Cervical adenocarcinoma (24 cases) and adenosquamous carcinoma (16 cases), including the underlying non-neoplastic epithelium were examined for HPV-DNA using in situ polymerase chain reaction (PCR), which enabled visualization of the localization on a glass slide.
  • In adenocarcinoma, HPV-DNA was found in 13 cases (54%) and in eight cases in underlying non-neoplastic epithelium, resulting in a total of 21 positive cases (88%).
  • In adenosquamous carcinoma, HPV-DNA was detected in 12 cases (75%) and and the HPV-DNA localization of each component was pure adenocarcinoma, 28.6%; mixed, 54.5%; and pure squamous cell carcinoma, 83.3%.
  • In the underlying non-neoplastic epithelium, HPV-DNA was found more frequently in the squamous epithelium (73.3%) than the cervical glands (6.3%).
  • In conclusion, HPV-DNA was detected in 54% of adenocarcinoma, and the rate was elevated by HPV localization in the underlying non-neoplastic epithelium.
  • HPV infection in the underlying squamous epithelium might be related to the carcinogenesis, even in cervical adenocarcinoma.
  • HPV-DNA localization was different in each component of adenosquamous carcinoma.
  • [MeSH-major] Adenocarcinoma / virology. Carcinoma, Adenosquamous / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / pathology. Uterine Cervical Neoplasms / virology

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  • (PMID = 16704493.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / DNA Probes, HPV; 0 / DNA, Viral
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26. Fujita T, Fukuda K, Ohmura Y, Nishi H, Mano M, Komatsubara S, Doihara H, Shimizu N: Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection. J Hepatobiliary Pancreat Surg; 2005;12(2):147-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term survival of a patient with advanced adenosquamous carcinoma of the gallbladder after radical resection.
  • Patients with adenosquamous carcinoma of the gallbladder tend to present with a bulky tumor that frequently displays involvement with adjacent organs, and diagnosis is usually made at an advanced stage.
  • This may contribute to the poor prognosis of patients with adenosquamous carcinoma of the gallbladder compared to patients with adenocarcinoma.
  • We present herein a patient with advanced adenosquamous carcinoma of the gallbladder who is doing well with no evidence of recurrence more than 5 years after radical resection.
  • Gallbladder carcinoma was diagnosed, and radical resection, including partial gastrectomy, was performed.
  • Histopathologically, adenosquamous carcinoma was diagnosed, and it was graded as si, hinf0, binf0, pv0, a0, t4, n0, and stage IVa.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Gallbladder Neoplasms / surgery

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  • (PMID = 15868080.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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27. Imura J, Tomita S, Ono Y, Inaba F, Yamazaki T, Fukasawa I, Inaba N, Fujimori T: Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis. APMIS; 2005 Feb;113(2):140-4
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  • [Title] Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis.
  • We herein describe a case of adenosquamous carcinoma that developed in the endometrium together with non-neoplastic OGCs.
  • Histologically, the tumor was found to be an adenosquamous carcinoma containing a large number of OGCs and mononuclear cells (MNCs) that had infiltrated into the stroma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Endometrial Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology
  • [MeSH-minor] Aged. Cell Lineage. Female. Humans. Leukocytes, Mononuclear / metabolism. Leukocytes, Mononuclear / pathology

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  • (PMID = 15723689.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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28. Faria GR, Eloy C, Preto JR, Costa EL, Almeida T, Barbosa J, Paiva ME, Sousa-Rodrigues J, Pimenta A: Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. J Med Case Rep; 2010;4:351

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report.
  • Primary gastric adenosquamous carcinoma is a rare malignancy, mostly associated with Asian populations.
  • It constitutes less than one percent of all gastric carcinomas and its clinical presentation is the same as adenocarcinoma.
  • It occurs more frequently in the proximal stomach, usually presents with muscular layer invasion and tends to be found in advanced stages at diagnosis, with a worse prognosis than adenocarcinoma.
  • CASE PRESENTATION: We report the case of an 84-year-old Caucasian woman with an adenosquamous carcinoma extending to her serosa with lymphatic and venous invasion (T3N1M1).
  • Nodal and hepatic metastasis presented with both cellular types, with dominance of the squamous component.
  • CONCLUSIONS: Adenosquamous gastric cancer is a rare diagnosis in western populations.
  • We present the case of a woman with a very aggressive adenosquamous carcinoma with a preponderance of squamous cell component in the metastasis.
  • Several origins have been proposed for this kind of carcinoma; either evolution from adenocarcinoma de-differentiation or stem cell origin might be possible.
  • The hypothesis that a particular histological type of gastric cancer may arise from stem cells might be a field of research in oncological disease of the stomach.

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  • (PMID = 21034475.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2984469
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29. Noël JC, Buxant F, Engohan-Aloghe C: Low-grade adenosquamous carcinoma of the breast--A case report with a BRCA1 germline mutation. Pathol Res Pract; 2010 Jul 15;206(7):511-3
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  • [Title] Low-grade adenosquamous carcinoma of the breast--A case report with a BRCA1 germline mutation.
  • Breast cancers occurring in women with germline BRCA1 mutations tend to fall into the category of triple-negative or basal-like phenotypes, such as metaplastic carcinoma.
  • Low-grade adenosquamous carcinoma of the breast is a rare variant of metaplastic carcinoma.
  • We present the case of a 49-year-old woman with a past medical history of invasive ductal breast carcinoma 13 years ago, and who was recently diagnosed as having a low-grade adenosquamous carcinoma in the same breast.
  • To our knowledge, BRCA1 mutation in association with a low-grade adenosquamous carcinoma of the breast has not yet been reported.
  • [MeSH-major] Breast Neoplasms / genetics. Breast Neoplasms / pathology. Carcinoma, Adenosquamous / genetics. Carcinoma, Adenosquamous / pathology. Genes, BRCA1
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Ductal, Breast / pathology. Female. Germ-Line Mutation. Humans. Immunohistochemistry. Middle Aged. Neoplasms, Second Primary / genetics. Neoplasms, Second Primary / pathology

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  • [Copyright] Copyright 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20189727.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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30. Yoshida T, Sano T, Oyama T, Kanuma T, Fukuda T: Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. Virchows Arch; 2009 Sep;455(3):253-9
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  • [Title] Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma.
  • Adenosquamous carcinoma of the uterine cervix is a rare mixture of malignant squamous and glandular epithelial elements and accounts for approximately 10% of cervical carcinomas.
  • The aims of the present study were to evaluate the prevalence, physical status, and viral load of HPV 16 and 18 in adenosquamous carcinoma.
  • Formalin-fixed paraffin-embedded tissue samples from 20 cases of histologically diagnosed adenosquamous carcinoma were examined.
  • The squamous and glandular components were separately microdissected and analyzed for their HPV DNA subtype, viral load, and physical status using real-time polymerase chain reaction (PCR).
  • The percentages of HPV 16- and 18-positive cases among all the HPV-positive cases were 36.8% (7/19) and 57.9% (11/19) in the squamous epithelial elements and 33.3% (6/18) and 61.1% (11/18) in the glandular elements, respectively.
  • The mean HPV 16 DNA copy numbers/cell was 7.22 in the squamous elements and 1.33 in the glandular elements (p=0.04) while the corresponding mean HPV 18 DNA copy numbers/cell was 1.50 and 0.89, respectively.
  • The prevalence of HPV 18 in adenosquamous carcinoma was high and many HPV 18-positive cases were the pure integrated form resulting in very low copy numbers/cell.
  • [MeSH-major] Carcinoma, Adenosquamous / virology. Human papillomavirus 16 / isolation & purification. Human papillomavirus 18 / isolation & purification. Uterine Cervical Neoplasms / virology

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  • (PMID = 19727809.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Viral
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31. Toyooka S, Yatabe Y, Tokumo M, Ichimura K, Asano H, Tomii K, Aoe M, Yanai H, Date H, Mitsudomi T, Shimizu N: Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung. Int J Cancer; 2006 Mar 15;118(6):1588-90
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  • [Title] Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Genes, ras / genetics. Lung Neoplasms / pathology. Mutation. Receptor, Epidermal Growth Factor / genetics

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  • (PMID = 16187277.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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32. Bjerregaard JK, Schønnemann KR, Jensen HA, Vestermark LW, Hansen TP, Pfeiffer P: Biweekly cetuximab and irinotecan as second-line therapy to patients with platinium-resistant gastroesophageal cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e15624

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  • METHODS: All pts had histologically confirmed GE cancer (adeno- or squamous cell carcinoma) and all pts had previously received first line platinum based therapy.

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  • (PMID = 27962695.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Ishii H, Furuse J, Boku N, Okusaka T, Ikeda M, Ohkawa S, Fukutomi A, Hamamoto Y, Nakamura K, Fukuda H: Phase II study of gemcitabine chemotherapy alone for locally advanced pancreatic carcinoma: JCOG 0506. J Clin Oncol; 2009 May 20;27(15_suppl):e15578

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  • [Title] Phase II study of gemcitabine chemotherapy alone for locally advanced pancreatic carcinoma: JCOG 0506.
  • METHODS: Eligibility criteria included the following: patients (pts) with histologically or cytologically proven pancreatic adenocarcinoma or adenosquamous carcinoma, pts with UICC clinical stage III (T4N0-1 and M0), all lesions are assumed to be included in the radiation field of 15 cm square, age 20 or older, no prior treatment for LAPC, ECOG performance status of 0, 1 or 2, and adequate organ function.
  • Gem was given intravenously at a dose of 1,000 mg/m2 over 30 minutes on days 1, 8 and 15, repeated every 4 weeks until disease progression.
  • Serum CA 19-9 level was reduced by >50% in 37.5% of 40 pts with baseline CA19-9 >100U/ml.

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  • (PMID = 27962370.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Yan M, Zhang YN, He JH, Huang H: [Prognosis analysis of 83 cases of cervical adenosquamous carcinoma]. Ai Zheng; 2008 Sep;27(9):956-61
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  • [Title] [Prognosis analysis of 83 cases of cervical adenosquamous carcinoma].
  • BACKGROUND & OBJECTIVE: Cervical adenosquamous carcinoma is a special histological type of cervical carcinoma.
  • This study was to explore the clinic-pathologic characteristics and prognostic factors of cervical adenosquamous carcinoma.
  • METHODS: Clinical data of 83 pathologically confirmed adenosquamous cervical carcinoma patients in Sun Yat-sen University Cancer Center from Nov.
  • RESULTS: The median overall survival (OS) of 83 patients was 47 months and the median disease-free survival was 43 months.
  • CONCLUSIONS: Lymph node metastasis is an independent risk factor for prognosis in cervical adenosquamous carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / therapy. Hysterectomy / methods. Uterine Cervical Neoplasms / therapy
  • [MeSH-minor] Aclarubicin / therapeutic use. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brachytherapy. Chemotherapy, Adjuvant. Cisplatin / therapeutic use. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Peplomycin / therapeutic use. Prognosis. Proportional Hazards Models. Radiotherapy, Adjuvant. Survival Rate. Tumor Burden

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  • (PMID = 18799035.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 56H9L80NIZ / Peplomycin; 74KXF8I502 / Aclarubicin; Q20Q21Q62J / Cisplatin; CAP therapy protocol
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35. Shin JU, Jung JT, You SS, Kwon JG, Kim EY, Lee CH, Kim HG, Park JB: [A case of primary adenosquamous carcinoma of the liver with formation of colonic fistula]. Korean J Gastroenterol; 2006 Nov;48(5):360-4
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  • [Title] [A case of primary adenosquamous carcinoma of the liver with formation of colonic fistula].
  • Primary adenosquamous carcinoma of the liver is generally considered as an extremely rare subtype of cholangiocarcinoma.
  • Recently, we experienced a case of primary adenosquamous carcinoma of liver with a formation of tumor-colonic fistula.
  • Colonoscopic examination showed a large colonic wall defect in hepatic flexure and a friable, nodular mucosa around the defected colonic wall.
  • Microscopically, the tumor was composed of squamous cell carcinoma mainly with foci of the adenocarcinoma component.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Colonic Diseases / pathology. Intestinal Fistula / pathology. Liver Neoplasms / pathology

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  • (PMID = 17132926.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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36. Lampropoulos P, Filippou G, Skafida E, Vasilakaki T, Paschalidis N, Rizos S: Adenosquamous carcinoma of the pancreas, a rare tumor entity: a case report. Cases J; 2009;2:9129

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the pancreas, a rare tumor entity: a case report.
  • INTRODUCTION: Adenosquamous carcinoma of the pancreas is a rare variant of exocrine pancreatic tumor.
  • Pancreatic carcinoma of the head was diagnosed and a pylorus preserving pancreaticoduodenectomy was performed.

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  • [Cites] World J Surg Oncol. 2008;6:95 [18764955.001]
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  • (PMID = 20062646.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803926
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37. Ishiguro A, Takahata T, Hirose K, Matsumoto Y, Tanaka S, Suzuki K, Hanada N, Itoh J, Kawasaki H, Kijima H, Fukuda S, Saijo Y: [A case of gastric adenosquamous carcinoma successfully treated with second-line chemotherapy (CPT-11 and CDDP)]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1579-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of gastric adenosquamous carcinoma successfully treated with second-line chemotherapy (CPT-11 and CDDP)].
  • Gastric adenosquamous carcinoma is known as an infrequent histological cancer with a poor prognosis.
  • A 69-year-old man was revealed to have gastric squamous carcinoma on the gastric body remote from esophagus (cT4 cN3, cStage IV).
  • The final histological diagnosis showed gastric adenosquamous carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Camptothecin / analogs & derivatives. Carcinoma, Adenosquamous / drug therapy. Cisplatin / therapeutic use. Stomach Neoplasms / drug therapy

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  • (PMID = 20716891.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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38. Kothari RK, Ghosh A, Bhattacharyya SK, Ghosh SK: Adenosquamous carcinoma of oral cavity: a case report. J Indian Med Assoc; 2007 Sep;105(9):531-2
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of oral cavity: a case report.
  • Histopathological examination of the biopsied material showed features suggestive of adenosquamous carcinoma, but CT-guided fine needle aspiration cytology from lung mass showed evidence of non-keratinising squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Mouth Neoplasms / diagnosis

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  • (PMID = 18338480.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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39. Fujita T, Fukuda K, Nishi H, Takao T, Ohmura Y, Mano M, Komatsubara S: Paraneoplastic hypercalcemia with adenosquamous carcinoma of the colon. Int J Clin Oncol; 2005 Apr;10(2):144-7
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  • [Title] Paraneoplastic hypercalcemia with adenosquamous carcinoma of the colon.
  • Here we present the first case of adenosquamous carcinoma of the sigmoid colon in a patient who was found to have hypercalcemia associated with parathyroid hormone-related protein (PTHrP), with no radiological evidence of metastasis to other organs.
  • The histopathologic diagnosis was poorly differentiated adenosquamous carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / complications. Colonic Neoplasms / complications. Hypercalcemia / etiology. Paraneoplastic Syndromes / etiology

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  • (PMID = 15864702.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein
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40. Gu MJ, Choi JH, Park WK, Chang JC, Kim HJ: [Primary adenosquamous carcinoma of the liver: a case report]. Korean J Hepatol; 2005 Mar;11(1):86-9
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  • [Title] [Primary adenosquamous carcinoma of the liver: a case report].
  • Primary adenosquamous cell carcinoma of the liver, a variant of cholangiocarcinoma is very rare disease and its prognosis is known to be very poor.
  • We describe here a case of primary adenosquamous carcinoma of the liver.
  • Needle biopsy of the mass was done and the histologic diagnosis was cholangiocarcinoma.
  • Microscopically, the tumor was composed of both adenocarcinoma and squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 15788889.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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41. Kobayashi M, Okabayashi T, Okamoto K, Namikawa T, Araki K: A clinicopathologic study of primary adenosquamous carcinoma of the liver. J Clin Gastroenterol; 2005 Jul;39(6):544-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathologic study of primary adenosquamous carcinoma of the liver.
  • BACKGROUND: Adenosquamous carcinoma (ASC) is a rare tumor of the liver, which carries a poor prognosis.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Liver Neoplasms / pathology

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  • (PMID = 15942444.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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42. Jiang L, Ji N, Zhou Y, Li J, Liu X, Wang Z, Chen Q, Zeng X: CAL 27 is an oral adenosquamous carcinoma cell line. Oral Oncol; 2009 Nov;45(11):e204-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CAL 27 is an oral adenosquamous carcinoma cell line.
  • CAL 27 is one of the most frequently used cell lines in the field of oral squamous cell carcinoma (OSCC) studying.
  • Then, we performed tumor formation assay, HE staining and immunohistochemistry assay to further study the growing characteristics and histopathological diagnosis of CAL 27 xenografts.
  • The CAL 27 xenografts were then diagnosed as oral adenosquamous carcinomas.
  • Thus CAL 27 appears to be an oral adenosquamous carcinoma cell line.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Cell Line, Tumor / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Carcinoma / pathology. Carcinoma, Squamous Cell. Head and Neck Neoplasms / pathology. Humans. Neoplasms, Squamous Cell / pathology. Transplantation, Heterologous

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  • (PMID = 19631575.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] Carcinoma, squamous cell of head and neck
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43. Vrdoljak E, Boraska Jelavic T, Saratlija-Novakovic Z, Hamm W: Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in the treatment of locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri. Eur J Gynaecol Oncol; 2005;26(6):602-4
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  • [Title] Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in the treatment of locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri.
  • The optimal treatment of women with locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri is still undefined.
  • We report a series of four consecutive patients with locally advanced adeno- or adenosquamous carcinomas of the uterine cervix (FIGO Stages IB-IIIB) treated by concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by one to four cycles of consolidation chemotherapy with the same drug combination.
  • Now, after a median follow-up of 40 (range: 13.5-61) months all patients still present with no evidence of disease.
  • Despite the low number of patients in this series we may conclude that concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy with the same drug combination is an efficacious treatment of patients with locally advanced adeno- or adenosquamous carcinomas of the cervix uteri.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brachytherapy. Carcinoma, Adenosquamous / drug therapy. Uterine Cervical Neoplasms / drug therapy


44. Riedlinger WF, Hurley MY, Dehner LP, Lind AC: Mucoepidermoid carcinoma of the skin: a distinct entity from adenosquamous carcinoma: a case study with a review of the literature. Am J Surg Pathol; 2005 Jan;29(1):131-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma of the skin: a distinct entity from adenosquamous carcinoma: a case study with a review of the literature.
  • Mucoepidermoid carcinoma (MEC) of the skin is an exceedingly rare but distinctive neoplasm with respect to its histopathologic features.
  • Beneath an unremarkable epidermis, a circumscribed, cystic neoplasm, unattached to the surface, was characterized by the presence of vague lobules of low-grade-appearing squamous cells accompanied by mucigenic and clear cells.
  • The cytokeratin 20 and gross cystic disease fluid protein were nonreactive.
  • Inconsistency was encountered in the literature where some confusion existed as to whether MEC is synonymous with adenosquamous carcinoma of the skin.
  • Elsewhere in the body, the latter tumor type is a squamous and gland-forming neoplasm with intermediate- to high-grade features rather than a tumor with mucigenic cells intermingled among intermediate and squamous cells.
  • As in the case of MEC and adenosquamous carcinoma elsewhere in extracutaneous sites, we would propose that a pathologic distinction should be made in the skin for the sake of consistency and for prognostic purposes.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Carcinoma, Mucoepidermoid / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans

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  • (PMID = 15613868.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 45
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45. Lim SH, Yang HW, Kim A, Cha SW, Jung SH, Go H, Lee WC: Adenosquamous carcinoma of extrahepatic bile duct: a case report. Korean J Intern Med; 2007 Sep;22(3):206-10
MedlinePlus Health Information. consumer health - Palliative Care.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of extrahepatic bile duct: a case report.
  • Most malignant tumors originating from the biliary tract are adenocarcinomas, and adenosqamous carcinoma of Klatskin's tumor is a very rare finding.
  • The histopathologic findings showed adenosquamous carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Ducts, Extrahepatic. Carcinoma, Adenosquamous / diagnosis. Palliative Care

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  • [Cites] Int J Radiat Oncol Biol Phys. 2003 Dec 1;57(5):1357-65 [14630274.001]
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  • (PMID = 17939340.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2687689
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46. Tohma T, Yamamoto Y, Seki Y, Takaishi S, Sakuma Y, Funami Y, Tobita K: Weekly paclitaxel therapy is effective for gastric adenosquamous carcinoma: a case report. Hepatogastroenterology; 2009 Mar-Apr;56(90):568-70
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  • [Title] Weekly paclitaxel therapy is effective for gastric adenosquamous carcinoma: a case report.
  • On, pathological examination, a diagnosis of adenosquamous carcinoma was confirmed, and lymph node metastases around the perigastric areas were found.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Carcinoma, Adenosquamous / drug therapy. Paclitaxel / therapeutic use. Stomach Neoplasms / drug therapy

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  • (PMID = 19579645.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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47. Smoot RL, Zhang L, Sebo TJ, Que FG: Adenosquamous carcinoma of the pancreas: a single-institution experience comparing resection and palliative care. J Am Coll Surg; 2008 Sep;207(3):368-70
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  • [Title] Adenosquamous carcinoma of the pancreas: a single-institution experience comparing resection and palliative care.
  • BACKGROUND: Adenosquamous carcinoma is a rare malignancy of the exocrine pancreas.
  • STUDY DESIGN: Records were reviewed for patients with adenosquamous pancreatic cancer evaluated during the years 1985 to 2003.
  • RESULTS: Twenty-three patients were identified with adenosquamous carcinoma of the pancreas.
  • CONCLUSIONS: The retrospective review of our single-institution experience with resection and palliative care for adenosquamous cancer of the pancreas has demonstrated a longer survival for patients that can undergo an R0 resection.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Palliative Care. Pancreatectomy. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Aged. Disease Progression. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Length of Stay. Male. Middle Aged. Neoplasm Invasiveness. Postoperative Complications / etiology. Postoperative Complications / mortality. Pyloric Antrum / surgery. Retrospective Studies

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  • (PMID = 18722942.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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48. Chou HH, Chang HP, Lai CH, Ng KK, Hsueh S, Wu TI, Chen MY, Yen TC, Hong JH, Chang TC: (18)F-FDG PET in stage IB/IIB cervical adenocarcinoma/adenosquamous carcinoma. Eur J Nucl Med Mol Imaging; 2010 Apr;37(4):728-35
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  • [Title] (18)F-FDG PET in stage IB/IIB cervical adenocarcinoma/adenosquamous carcinoma.
  • PURPOSE: The diagnostic and prognostic value of (18)F-FDG PET in cervical adenocarcinoma/adenosquamous carcinoma (AC/ASC) is unclear.
  • METHODS: Patients with resectable FIGO stage IB/IIB cervical AC/ASC receiving a preoperative MRI scan and a PET or PET/CT scan before radical surgery were eligible.
  • [MeSH-major] Adenocarcinoma / radionuclide imaging. Carcinoma, Adenosquamous / radionuclide imaging. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Radiopharmaceuticals. Uterine Cervical Neoplasms / radionuclide imaging

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  • (PMID = 20069296.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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49. Radić V, Kukura V, Ciglar S: Adenosquamous carcinoma of the uterine cervix--adjuvant chemotherapeutic treatment with paclitaxel and carboplatin; a case report. Eur J Gynaecol Oncol; 2005;26(4):449-50
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  • [Title] Adenosquamous carcinoma of the uterine cervix--adjuvant chemotherapeutic treatment with paclitaxel and carboplatin; a case report.
  • Adenosquamous carcinoma of the uterine cervix is a rare mixture of malignant glandular and squamous epithelial elements.
  • We present a case of a 56-year-old woman with Stage IV cervical carcinoma treated with paclitaxel and carboplatin chemotherapy after cytoreductive surgery.
  • The patient died 20 months after establishing the diagnosis.
  • Paclitaxel in combination with carboplatin as adjuvant chemotherapeutic treatment could be another promising agent for patients with advanced metastatic cervical adenocarcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenosquamous / therapy. Liver Neoplasms / therapy. Uterine Cervical Neoplasms / therapy

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  • (PMID = 16122201.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Sclerosing Solutions; 3K9958V90M / Ethanol; 3Z8479ZZ5X / Epirubicin; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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50. Teramoto N, Nishimura R, Saeki T, Nogawa T, Hiura M: Adenoid basal carcinoma of the uterine cervix: report of two cases with reference to adenosquamous carcinoma. Pathol Int; 2005 Jul;55(7):445-52
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

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  • [Title] Adenoid basal carcinoma of the uterine cervix: report of two cases with reference to adenosquamous carcinoma.
  • Adenoid basal carcinoma (ABC) of the uterine cervix is a rare neoplasm with excellent prognosis.
  • Differential diagnosis between ABC and an ABC-like lesion of adenosquamous cell carcinoma (ASC) of the cervix is important due to their contrasting prognosis.
  • The two ABC were incidentally found in the uterine cervix of 69-year-old and 59-year-old Japanese women due to cervical intraepithelial neoplasia grade 3 and to squamous cell carcinoma, respectively.
  • An ABC-like lesion was defined as basaloid cell nests simulating ABC, but with some features indicating malignant potential.
  • However, the differential diagnosis was sometimes difficult because two of seven ABC-like lesions were originally diagnosed as ABC.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-7. Keratin-8. Keratins / analysis. Ki-67 Antigen / analysis. Middle Aged

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  • (PMID = 15982222.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / KRT8 protein, human; 0 / Keratin-7; 0 / Keratin-8; 0 / Ki-67 Antigen; 68238-35-7 / Keratins
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51. Okabayashi K, Hasegawa H, Ishii Y, Endo T, Kitagawa Y: Adenosquamous carcinoma of the sigmoid colon treated by the less invasive procedures of endoscopy and laparoscopy: report of a case. Surg Today; 2009;39(11):994-7
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  • [Title] Adenosquamous carcinoma of the sigmoid colon treated by the less invasive procedures of endoscopy and laparoscopy: report of a case.
  • A 51-year-old man demonstrated a positive finding for a fecal occult blood test during a screening examination.
  • Total colonoscopy was therefore performed, and a semi-pedunculated polyp was detected in the sigmoid colon.
  • Although this polyp was suspected of invading the submucosal layer, it was removed endoscopically because the preoperative diagnosis was well-differentiated adenocarcinoma.
  • The pathological findings revealed adenosquamous carcinoma that had invaded the submucosal layer with lymphatic invasion.
  • A laparoscopic bowel resection was then performed and a histopathological examination of the surgical specimen showed metastasis to two regional lymph nodes.
  • Adenosquamous carcinoma has been reported to be rare and to possess a highly metastatic potential.
  • It consists of both squamous cells and glandular cell components.
  • We report a case of adenosquamous carcinoma of the sigmoid colon treated by less invasive approaches consisting of an endoscopic mucosal resection and a subsequent laparoscopic colectomy.
  • [MeSH-major] Carcinoma, Adenosquamous / surgery. Colectomy / methods. Colon, Sigmoid / surgery. Colonoscopy / methods. Laparoscopy / methods. Sigmoid Neoplasms / surgery

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  • (PMID = 19882324.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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52. Romero FR, de Castro MG, Garcia CR, Perez MD: Adenosquamous carcinoma of the penis. Clinics (Sao Paulo); 2006 Aug;61(4):363-4

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  • [Title] Adenosquamous carcinoma of the penis.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Penile Neoplasms / pathology

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  • (PMID = 16924331.001).
  • [ISSN] 1807-5932
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Brazil
  • [Number-of-references] 9
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53. Dong Y, Wang J, Ma H, Zhou H, Lu G, Zhou X: Primary adenosquamous carcinoma of the colon: report of five cases. Surg Today; 2009;39(7):619-23
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  • [Title] Primary adenosquamous carcinoma of the colon: report of five cases.
  • Primary adenosquamous cell carcinomas (Ad-SCCs) of the colon and rectum are rare malignancies with a poor prognosis, in comparison to adenocarcinoma alone.
  • Different roles of human papilloma virus (HPV) in its pathogenesis have been reported and the role of P16 in Ad-SCCs has not been explored.
  • This report presents five cases of Ad-SCC of the colon to explore the clinicopathological features and the roles of P16, HPV 6/11, and 16/18.
  • There was no confirmed evidence to support the relationship between the infection of HPV 6/11, 16/18, and pathogenesis of Ad-SCC of the colon.
  • P16 overexpression was not related to HPV carcinogenesis and there might be another mechanism of P16 upregulation in Ad-SCC of the colon.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / virology. Colonic Neoplasms / pathology. Colonic Neoplasms / virology. Papillomavirus Infections / virology

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  • (PMID = 19562453.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / P16 protein, human
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54. Jamali M, Serra S, Chetty R: Adenosquamous carcinoma of the pancreas with clear cell and rhabdoid components. A case report. JOP; 2007;8(3):330-4
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  • [Title] Adenosquamous carcinoma of the pancreas with clear cell and rhabdoid components. A case report.
  • CONTEXT: In as much as no such variant of this pancreatic tumour has been previously reported in the literature, we report an unusual case of an adenosquamous carcinoma of the pancreas characterized by clear cells and rhabdoid cells.
  • Endoscopic retrograde pancreatography showed mild to moderate dilatation of the intrapancreatic biliary tract and of the pancreatic duct, and a biliary stent was placed.
  • Histological evaluation of the pancreatic mass revealed an adenosquamous carcinoma displaying both clear cell and rhabdoid components.
  • CONCLUSIONS: Assessing the predominant histology of pancreatic adenosquamous carcinoma variants such as those characterized by clear cells and rhabdoid cells may help select and improve upon therapies in this aggressive lesion.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Pancreatic Neoplasms / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 17495363.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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55. Nomura M, Inoue Y, Fujita S, Sakao J, Hirota M, Souda S: [A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy]. Gan To Kagaku Ryoho; 2006 Jan;33(1):99-103
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  • [Title] [A case of gastric adenosquamous carcinoma with abdominal paraaortic lymph node metastases successfully treated by TS-1 plus CDDP neoadjuvant chemotherapy].
  • The preoperative diagnosis was cStage IV gastric cancer (cT 3, cN 3, cH 0, cP 0, cM 0).
  • Histopathologically, the tumor was diagnosed as adenosquamous carcinoma of the stomach with lymph node metastasis at only No.3.
  • This case suggests that neoadjuvant chemotherapy using TS-1 plus CDDP is effective for advanced gastric adenosquamous carcinoma with massive lymph node metastases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenosquamous / drug therapy. Carcinoma, Adenosquamous / secondary. Lymph Nodes / pathology. Stomach Neoplasms / pathology

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  • (PMID = 16410707.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Pyridines; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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56. Uchikado Y, Natsugoe S, Okumura H, Matsumoto M, Setoyama T, Takigawa J, Haraguchi Y, Ishigami S, Aikou T: [A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma]. Gan To Kagaku Ryoho; 2006 Jan;33(1):83-5
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  • [Title] [A case of successful treatment by low-dose 5-fluorouracil and cisplatin for liver metastases of esophageal adenosquamous carcinoma].
  • Adenosquamous carcinoma of the esophagus is an uncommon type of esophageal tumor.
  • In the present case, a 54-year-old man without symptoms was diagnosed with esophageal squamous cell carcinoma, based on endoscopic examination of a biopsy specimen.
  • The histological diagnosis was adenosquamous carcinoma with no lymph node metastasis.
  • Based on the present findings, we recommend low-dose 5-fluorouracil/cisplatin therapy for liver metastasis from esophageal adenosquamous carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Adenosquamous / drug therapy. Carcinoma, Adenosquamous / secondary. Esophageal Neoplasms / pathology. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 16410703.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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57. Fukui D, Bando G, Ishikawa Y, Kadota K: Adenosquamous carcinoma with cilium formation, mucin production and keratinization in the nasal cavity of a red fox (Vulpes vulpes schrencki). J Comp Pathol; 2007 Aug-Oct;137(2-3):142-5
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  • [Title] Adenosquamous carcinoma with cilium formation, mucin production and keratinization in the nasal cavity of a red fox (Vulpes vulpes schrencki).
  • A diagnosis of adenosquamous carcinoma was made in an 11-year-old red fox.
  • The nasal and oral lesions were composed of adenocarcinomatous cells and squamous cells, the latter predominating in the oral lesions.
  • The marrow of the palatine bone also contained neoplastic tissue, which consisted of cysts and keratin masses surrounded by well-differentiated squamous cells.
  • Neoplastic basal cells and less-differentiated adenocarcinoma cells, which were identifiable by immunolabelling for cytokeratin 5 (CK5) and CK18, were considered to be pluripotential.
  • These cells, which lined tubular structures, were distinct from intermediate cells in mucoepidermoid carcinoma, which can differentiate into squamous and mucin-producing cells but have a nondescript appearance.
  • [MeSH-major] Carcinoma, Adenosquamous / veterinary. Cilia / pathology. Foxes. Keratins / metabolism. Mucins / metabolism. Nose Neoplasms / veterinary

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  • (PMID = 17645890.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Keratin-5; 0 / Mucins; 68238-35-7 / Keratins
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58. Manonukul J, Omeapinyan P, Vongjirad A: Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. Am J Dermatopathol; 2009 Oct;31(7):658-63
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  • [Title] Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case.
  • We report a case of a 66-year-old woman with a coexistence of trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum, syringocystadenoma papilliferum, and mucoepidermoid or adenosquamous carcinoma arising in 2 separate and persistent SNJ exhibiting on her face with subsequent parotid node metastasis.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology

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  • (PMID = 19652586.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Meng YH, Li S, Hu T, Ma D, Lu YP, Wang H: [Clinical analysis of 132 cases of cervical adenosquamous carcinoma and cervical adenocarcinoma]. Chin J Cancer; 2010 Jan;29(1):15-9
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  • [Title] [Clinical analysis of 132 cases of cervical adenosquamous carcinoma and cervical adenocarcinoma].
  • BACKGROUND AND OBJECTIVE: The incidence of cervical adenosquamous carcinoma is relatively low.
  • This study was to analyze the clinicopathologic characteristics and prognostic factors of cervical adenosquamous carcinoma.
  • METHODS: Clinical data of 44 cervical adenosquamous carcinoma patients and 88 cervical adenocarcinoma patients(control), treated from January 2002 to December 2007, were analyzed using Chi-square test, Kaplan-Meier method, log-rank test, and Cox regression model.
  • RESULTS: The proportion of large tumors (maximal diameter > 4 cm) was significantly higher in cervical adenosquamous carcinoma group than in cervical adenocarcinoma group (47.7% vs. 28.4%, P<0.05); the proportion of poorly differentiated tumors was significantly higher in cervical adenosquamous carcinoma group than in cervical adenocarcinoma group (56.8% vs. 30.7%, P<0.05).
  • There was no significant difference of 2-year overall and disease-free survival rates between the two groups (P>0.05).
  • CONCLUSIONS: Cervical adenosquamous carcinoma is characterized by large tumor size and poor differentiation.
  • There is no difference in prognosis between cervical adenosquamous carcinoma and cervical adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenosquamous / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / secondary. Disease-Free Survival. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Kaplan-Meier Estimate. Lung Neoplasms / secondary. Lymph Node Excision. Lymphatic Metastasis. Middle Aged. Neoadjuvant Therapy. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Pelvic Neoplasms / secondary. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Rate. Tumor Burden

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  • (PMID = 20038304.001).
  • [ISSN] 1000-467X
  • [Journal-full-title] Chinese journal of cancer
  • [ISO-abbreviation] Chin J Cancer
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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60. Sugio K, Nagashima A, Nakanishi R, Uchiyama A, Inoue M, Osaki T, Yoshimatsu T, Takenoyama M, Hanagiri T, Yasumoto K: Randomized phase II trial of the biweekly schedule of adjuvant chemotherapy with carboplatin plus paclitaxel versus carboplatin plus gemcitabine in patients with non-small cell lung cancer (NSCLC). J Clin Oncol; 2009 May 20;27(15_suppl):7562

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Randomized phase II trial of the biweekly schedule of adjuvant chemotherapy with carboplatin plus paclitaxel versus carboplatin plus gemcitabine in patients with non-small cell lung cancer (NSCLC).
  • The primary endpoint was compliance, and secondary endpoints were the disease free survival (DFS) and toxicity.
  • The patients were stratified by gender, histology (adenoca vs. non-adenoca) and disease stage.
  • The histologic types included adenocarcinoma (n=51), squamous cell carcinoma (n=18), large cell carcinoma (n=5), and adenosquamous cell carcinoma (n=1).
  • Twenty-one of 39 pts (54%) in arm A and 25 of 36 pts (69%) in arm B completed 8 cycles, and 59% in arm A and 81% in arm B completed ≥6 cycles.
  • Up to 12/2008, 11 of 39 pts in arm A and 13 of 36 pts in arm B had recurrent disease, but no significant difference was observed.

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  • (PMID = 27963358.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Yokoi K, Tanaka N, Furukawa K, Seya T, Ohaki Y, Tajiri T: Case of adenosquamous carcinoma of the ascending colon. J Nippon Med Sch; 2008 Aug;75(4):242-6
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  • [Title] Case of adenosquamous carcinoma of the ascending colon.
  • Adenocarcinoma accounts for most of the malignant tumors originating from the colon, whereas adenosquamous carcinoma is rare, accounting for about 0.1% of all colon cancers.
  • We present herein a case of adenosquamous carcinoma of the ascending colon.
  • A barium enema examination and lower gastrointestinal endoscopy showed a type 3 tumor in the ascending colon, and a biopsy confirmed the diagnosis of adenosquamous carcinoma.
  • A search of Japanese literature over the past 25 years yielded 70 patients with adenosquamous carcinoma of the colon, and the clinicopathological features are discussed herein.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Colonic Neoplasms / diagnosis

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  • (PMID = 18781050.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Cai HN, Wu XF, Xiang QY, Xiong YY, Zeng J: [Clinical analysis of 21 cases of cervical adenosquamous carcinoma]. Zhonghua Fu Chan Ke Za Zhi; 2008 Feb;43(2):124-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 21 cases of cervical adenosquamous carcinoma].
  • OBJECTIVE: To study the clinical characteristics, treatment modalities and prognosis of cervical adenosquamous carcinoma.
  • METHODS: The data of 21 patients with adenosquamous cervical cancer who were admitted into Zhongnan Hospital, Wuhan University from Jan 2001 to Dec 2005 were analyzed retrospectively.
  • CONCLUSIONS: Combined therapy should be given to patients with adenosquamous carcinoma of the cervix.
  • Surgical therapy and chemotherapy play an important role in the management and prognosis of adenoquamous carcinoma of cervix.
  • Preserve of ovary for patients with adenosquamous carcinoma of the cervix should only be done when the ovary is confirmed free from any malignant involvement by pathology.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / therapy. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / therapy


63. Cherian I, Shrestha SP, Panhani ML, Talwar OP, Yogi N, Rai S, Lalchan S, Fernandes C: Adenosquamous carcinoma of the lacrimal gland. BMJ Case Rep; 2010;2010
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  • [Title] Adenosquamous carcinoma of the lacrimal gland.
  • A 48-year-old man presented with proptosis of the left eye, which on excisional biopsy proved to be primary adenosquamous carcinoma of the lacrimal gland.
  • Primary adenosquamous carcinoma of the lacrimal gland is a very rare entity and, following a thorough literature review, only two cases of lacrimal gland adenosquamous carcinoma have been reported so far.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis

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  • [Cites] Ophthalmology. 2004 May;111(5):997-1008 [15121380.001]
  • [Cites] J Med Assoc Thai. 2002 Sep;85(9):1028-36 [12450084.001]
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  • (PMID = 22802328.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029430
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64. Sheahan P, Toner M, Timon CV: Clinicopathological features of head and neck adenosquamous carcinoma. ORL J Otorhinolaryngol Relat Spec; 2005;67(1):10-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological features of head and neck adenosquamous carcinoma.
  • Adenosquamous carcinoma is a rare tumour which is characterized pathologically by the simultaneous presence of distinct areas of squamous cell carcinoma and adenocarcinoma.
  • The origin of adenosquamous carcinoma is controversial; however, it is generally considered to be aggressive and associated with a dismal prognosis.
  • In the present study, the medical and pathological records of 4 patients with head and neck adenosquamous carcinoma are reviewed.
  • In 1 patient, the tumour arose from an area of carcinoma in situ of surface epithelium.
  • One patient died of postoperative complications, 1 suffered from local recurrence and developed distant metastases and 2 were alive with no evidence of disease over 30 months later.
  • Adenosquamous carcinoma is an aggressive tumour; however, with appropriate treatment, some patients may remain well beyond 2 years.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Head and Neck Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15637416.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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65. Li B, Li Z, Zhang Y, Li Y, Wu W: [Clinical analysis of surgically treated patients with adenosquamous carcinoma of the lung]. Zhongguo Fei Ai Za Zhi; 2006 Oct 20;9(5):469-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of surgically treated patients with adenosquamous carcinoma of the lung].
  • BACKGROUND: Adenosquamous carcinoma of the lung is a rare pathologic type of lung cancer.
  • The aim of this study is to explore the clinical features of adenosquamous carcinoma of the lung.
  • METHODS: A total of 115 patients with adenosquamous carcinoma of the lung were retrospectively analysed, who were diagnosed by operation and pathology.
  • There were 14 patients (12.17%) without any symptom and 16 patients had residual carcinoma at the resection margin (14.04%).
  • CONCLUSIONS: The incidence of adenosquamous carcinoma of the lung in young women (under 49 years, especially under 39 years) is rather high.
  • The residual carcinoma at the resection margin often occurs after routine operation.

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  • (PMID = 21176475.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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66. Koike S, Nasu T, Ishida A, Noda D, Ishii K, Aoyagi M: [A case of laryngeal adenosquamous carcinoma]. Nihon Jibiinkoka Gakkai Kaiho; 2009 Oct;112(10):712-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of laryngeal adenosquamous carcinoma].
  • We report a rare case of adenosquamous carcinoma of the larynx.
  • Excisional laryngofissure biopsy led to a pathological diagnosis of adenosquamous carcinoma, necessitating laryngectomy with bilateral neck dissection (Level II-IV) and postoperative radiation therapy.
  • He died of metastatic disease 7.5 years after the initial treatment, without locoregional recurrence.
  • Among malignant laryngeal tumors, adenosquamous carcinoma is extremely rare, with only 33 such cases including ours reported in the literature.
  • [MeSH-major] Carcinoma, Adenosquamous. Laryngeal Neoplasms

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  • (PMID = 19894593.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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67. Neumann G, Rasmussen KL, Petersen LK: Cervical adenosquamous carcinoma: tumor implantation in an episiotomy scar. Obstet Gynecol; 2007 Aug;110(2 Pt 2):467-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cervical adenosquamous carcinoma: tumor implantation in an episiotomy scar.
  • BACKGROUND: We report a rare case of a cervical adenosquamous carcinoma, initially diagnosed during delivery, with subsequent implantation in the episiotomy scar 5 weeks postpartum.
  • CASE: A 35-year-old woman with cervical adenosquamous carcinoma diagnosed during delivery was treated with radical abdominal hysterectomy with bilateral pelvic lymphadenectomy.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Cicatrix / pathology. Episiotomy. Pregnancy Complications, Neoplastic / pathology. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Chemotherapy, Adjuvant. Combined Modality Therapy. Fatal Outcome. Female. Humans. Hysterectomy. Lymph Node Excision. Lymphatic Metastasis / pathology. Neoplasm Recurrence, Local. Pregnancy. Puerperal Disorders / diagnosis. Puerperal Disorders / pathology. Puerperal Disorders / therapy


68. Endo K, Kohnoe S, Okamura T, Haraguchi M, Adachi E, Toh Y, Baba H, Maehara Y: Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor. Gastric Cancer; 2005;8(3):173-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor.
  • We report a case of adenosquamous carcinoma of the stomach that produced granulocyte-colony stimulating factor (G-CSF).
  • The patient, who had an admission diagnosis of advanced gastric cancer, had marked leukocytosis without evidence of infection.
  • The resected stomach tumor was histologically diagnosed as adenosquamous carcinoma; positive expression of G-CSF by tumor cells was shown with immunohistochemical detection, which confirmed the preoperative diagnosis.
  • Recurrent disease in the liver and lymph nodes, accompanied by leukocytosis and re-elevation of serum G-CSF, developed just 3 months after the curative gastrectomy and adjuvant chemotherapy.
  • All of the recurrent disease was resected, restoring normal levels of serum G-CSF.
  • [MeSH-major] Carcinoma, Adenosquamous / metabolism. Granulocyte Colony-Stimulating Factor / metabolism. Leukocytosis / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 16086120.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
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69. Alwaheeb S, Chetty R: Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells. J Clin Pathol; 2005 Sep;58(9):987-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells.
  • Histological evaluation of the pancreatic tumour showed an adenosquamous carcinoma (predominantly composed of squamous carcinoma), which was extensively infiltrative with perineural invasion and involvement of peripancreatic lymph nodes.
  • Areas of pancreatic intraepithelial neoplasia grade III and merging of the squamous and adenocarcinoma components were evident.
  • Unusual histological features that characterised this case included a pronounced acantholytic pattern within the squamous carcinoma component, and the presence of both osteoclastic and pleomorphic giant cells.
  • Giant cells have not been documented previously in association with an adenosquamous carcinoma.
  • Although an acantholytic pattern has been noted in squamous carcinomas in other sites, this is the first report of such a pattern in an adenosquamous carcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Giant Cells / pathology. Osteoclasts / pathology. Pancreatic Neoplasms / pathology

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  • [Cites] Hum Pathol. 2000 Oct;31(10):1223-9 [11070115.001]
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  • (PMID = 16126885.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770836
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70. Zhang DK, Su XD, Lin P, Long H, Fu JH, Zhang LJ, Ma GW, Rong TH: [Clinical analysis of 22 cases of esophageal adenosquamous carcinoma]. Zhonghua Zhong Liu Za Zhi; 2009 Apr;31(4):302-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical analysis of 22 cases of esophageal adenosquamous carcinoma].
  • OBJECTIVE: This study was to review the clinical features, diagnosis, treatment, and prognosis of esophageal adenosquamous carcinoma (ASC).
  • Esophageal ASC showed similar clinical symptoms, radiological and endoscopic features to esophageal squamous cell carcinoma (ESCC).
  • CONCLUSION: Esophageal adenosquamous carcinoma is a rare esophageal disease and prone to be misdiagnosed as esophageal squamous cell carcinoma.
  • The prognosis of esophageal adenosquamous carcinoma has not yet been well established.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Carcinoma, Squamous Cell / diagnosis. Diagnostic Errors. Esophageal Neoplasms / diagnosis. Esophagectomy / methods

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  • (PMID = 19615289.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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71. Okabayashi T, Kobayashi M, Nishimori I, Namikawa T, Okamoto K, Onishi S, Araki K: Adenosquamous carcinoma of the extrahepatic biliary tract: clinicopathological analysis of Japanese cases of this uncommon disease. J Gastroenterol; 2005 Feb;40(2):192-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the extrahepatic biliary tract: clinicopathological analysis of Japanese cases of this uncommon disease.
  • BACKGROUND: We analyzed the clinicopathologic variables and postoperative outcomes in patients with extrahepatic adenosquamous carcinoma to identify important factors for predicting postresection prognosis.
  • METHODS: Thirty-six patients in Japan who underwent surgical resection for adenosquamous carcinoma of the extrahepatic biliary tract, with curative intent by the end of 2003, were studied.
  • A retrospective review, with univariate and multivariate analyses, was performed on the clinical records of patients who underwent surgical exploration for adenosquamous carcinoma of the common bile duct.
  • CONCLUSIONS: Curative surgical resection for adenosquamous carcinoma remains the only effective treatment, because it offers the chance of long-term survival.
  • [MeSH-major] Biliary Tract Neoplasms / pathology. Carcinoma, Adenosquamous / pathology

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  • (PMID = 15770404.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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72. Fumerton R, Afifi T, Martinka M, de Gannes G: Cutaneous metastases of cervical adenosquamous carcinoma. J Am Acad Dermatol; 2010 Aug;63(2):e48-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous metastases of cervical adenosquamous carcinoma.
  • [MeSH-major] Carcinoma, Adenosquamous / secondary. Cervical Intraepithelial Neoplasia / pathology. Skin Neoplasms / secondary

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  • (PMID = 20633787.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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73. Yu JQ, Yang ZG, Austin JH, Guo YK, Zhang SF: Adenosquamous carcinoma of the lung: CT-pathological correlation. Clin Radiol; 2005 Mar;60(3):364-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the lung: CT-pathological correlation.
  • AIM: To correlate CT morphological features and histopathological findings of adenosquamous carcinoma of the lung.
  • MATERIALS AND METHODS: In all, 29 patients underwent contrast-enhanced CT of an adenosquamous carcinoma of the lung, followed by resection of the cancer.
  • These CT features corresponded mainly to solid tumour growth, which was composed of both squamous cell carcinomatous and adenocarcinomatous tissue.
  • CONCLUSION: Adenosquamous carcinoma of the lung is shown to be characteristically a solid, lobulated nodule or mass, more commonly peripheral than central.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiography. Lung Neoplasms / pathology. Lung Neoplasms / radiography

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  • (PMID = 15710140.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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74. Terada T: Adenosquamous carcinoma of the ovary arising from endometriosis: two case reports. Cases J; 2009;2:6661

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenosquamous carcinoma of the ovary arising from endometriosis: two case reports.
  • The author reports two cases of adenosquamous carcinoma arising from endometriosis of ovaries.
  • Both patients underwent hysterectomy and bilateral salpingo-oophorectomy for ovarian carcinomas.
  • Histologically, the cystic areas consisted of endometrial glandular epithelium.
  • Both mural tumors were composed of grade I endometroid adenocarcinoma and squamous cell carcinoma.
  • A differentiation of endometrioid adenocarcinoma from the endometriosis were present in a few areas.
  • Likewise, a differentiation of squamous cell carcinoma from the endometriosis were recognized in several areas.
  • The pathologic diagnosis was adenosquamous carcinoma arising from endometriosis of the ovary in both cases, rather than endometrioid adenocarcinoma with malignant squamous differentiation.

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  • (PMID = 20184682.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827079
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75. Longatto-Filho A, Pinheiro C, Martinho O, Moreira MA, Ribeiro LF, Queiroz GS, Schmitt FC, Baltazar F, Reis RM: Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. BMC Cancer; 2009 Jun 29;9:212
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma.
  • BACKGROUND: Adenosquamous carcinoma of the uterine cervix is an infrequent but aggressive subtype of cervical cancer.
  • The objective of this study was to investigate EGFR, PDGFRA and VEGFR2 RTKs overexpression and activating gene mutations in a cohort of 30 adenosquamous carcinomas of the uterine cervix.
  • All PDGFRA immunohistochemical reactions were positive and consistently observed in the stromal component, staining fibroblasts and endothelial cells, as well as in the cytoplasm of malignant cells.
  • We also observed the presence of base substitutions in intron 14 (IVS14+3G>A and IVS14+49G>A) in two different cases, and in intron 18 (IVS18-50insA) in 4 cases.
  • CONCLUSION: This is the most extensive analysis of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinomas.
  • Despite the absence of EGFR and PDGFRA activating mutations, the presence of overexpression of these three important therapeutic targets in a subset of cases may be important in predicting the sensitivity of adenosquamous carcinoma to specific anti-RTKs drugs.
  • [MeSH-major] Carcinoma / genetics. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Receptor, Epidermal Growth Factor / genetics. Receptor, Platelet-Derived Growth Factor alpha / genetics. Uterine Cervical Neoplasms / genetics. Vascular Endothelial Growth Factor Receptor-2 / genetics

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  • (PMID = 19563658.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-2
  • [Other-IDs] NLM/ PMC2711112
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76. Sato T, Ito J, Shibuya H, Asano K, Watari T: Pulmonary adenosquamous carcinoma in a dog. J Vet Med A Physiol Pathol Clin Med; 2005 Dec;52(10):510-3
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  • [Title] Pulmonary adenosquamous carcinoma in a dog.
  • A mass that developed in the lung of a 10-year-old mixed-breed dog was pathologically examined.
  • Histopathological examination showed papillary and tubular growth of glandular epithelium-like cells in some areas and growth of squamous cells arranged in nests in other areas, showing coexistence of adenocarcinoma and squamous cell carcinoma in a lung tumour.
  • Electron microscopically, the neoplastic cells of the adenocarcinoma component had features of glandular cells, with microvilli, numerous free ribosomes, large round secretory granules and intercellular desmosomes.
  • Non-keratinized squamous cells had tonofilaments and intercellular desmosomes.
  • These findings led to the diagnosis of primary adenosquamous carcinoma, which demonstrates phenotypic profiles characteristic of both epidermal keratinocytes and glandular epithelium.
  • [MeSH-major] Carcinoma, Adenosquamous / veterinary. Dog Diseases / pathology. Lung Neoplasms / veterinary

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  • (PMID = 16300659.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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77. Joshita S, Nakazawa K, Sugiyama Y, Kamijo A, Matsubayashi K, Miyabayashi H, Furuta K, Kitano K, Kawa S: Granulocyte-colony stimulating factor-producing pancreatic adenosquamous carcinoma showing aggressive clinical course. Intern Med; 2009;48(9):687-91
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  • [Title] Granulocyte-colony stimulating factor-producing pancreatic adenosquamous carcinoma showing aggressive clinical course.
  • Specimens taken at necropsy revealed an adenosquamous carcinoma positive for G-CSF by immunohistochemistry; it was only the second reported case to date.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Granulocyte Colony-Stimulating Factor / biosynthesis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Female. Humans. Leukocytosis / diagnosis. Leukocytosis / immunology. Lung Neoplasms / immunology. Lung Neoplasms / secondary

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  • (PMID = 19420814.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
  • [Number-of-references] 27
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78. Uramoto H, Yamada S, Hanagiri T: Immunohistochemical staining with deltaNp63 is useful for distinguishing the squamous cell component of adenosquamous cell carcinoma of the lung. Anticancer Res; 2010 Nov;30(11):4717-20
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  • [Title] Immunohistochemical staining with deltaNp63 is useful for distinguishing the squamous cell component of adenosquamous cell carcinoma of the lung.
  • The aim of this study was to detect the deltaNp63 expression in the squamous carcinoma component of adenosquamous carcinoma and evaluate its usefulness as a specific squamous carcinoma marker.
  • PATIENTS AND METHODS: Immunohistochemistry was used to analyze the protein expression of deltaNp63 and high molecular weight cytokeratin in paraffin-embedded tumor samples from 17 patients with well-characterized adenosquamous carcinoma.
  • It was easy to discriminate the squamous carcinoma and adenocarcinoma components in all tumors.
  • CONCLUSION: These findings indicated that the deltaNp63 status was useful for distinguishing squamous carcinoma from adenocarcinoma in formalin-postfixed adenosquamous carcinoma specimens.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Adenosquamous / metabolism. Carcinoma, Non-Small-Cell Lung / metabolism. Carcinoma, Squamous Cell / metabolism. Lung Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 21115930.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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79. Niwa Y, Matsuo K, Ito H, Hirose K, Tajima K, Nakanishi T, Nawa A, Kuzuya K, Tamakoshi A, Hamajima N: Association of XRCC1 Arg399Gln and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects. Gynecol Oncol; 2005 Oct;99(1):43-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The cases comprised 131 cervical cancer patients: 87 cases with squamous cell carcinoma (SCC) and 44 with adenocarcinoma (ADC) or adenosquamous carcinoma (ADSC).
  • RESULTS: The frequency of the XRCC1 399GlnGln genotype was higher in individuals with adenocarcinoma/adenosquamous carcinoma than in the healthy controls (OR = 2.98, 95% CI = 1.11-8.01, P = 0.030).
  • In stratification analysis, significant elevated risk of adenocarcinoma/adenosquamous carcinoma was associated with the XRCC1 399GlnGln genotype among nonsmokers (OR = 3.85, 95% CI = 1.28-11.59, P = 0.017), but not among smokers.
  • CONCLUSION: This is the first report that the XRCC1 Arg399Gln polymorphism might be important in relation to the risk of adenocarcinoma/adenosquamous carcinoma of the cervix.
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / genetics. Adult. Aged. Aged, 80 and over. Alleles. Carcinoma, Adenosquamous / enzymology. Carcinoma, Adenosquamous / genetics. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / genetics. Case-Control Studies. Female. Genetic Predisposition to Disease. Humans. Japan. Middle Aged. Polymorphism, Genetic

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  • (PMID = 15990162.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / X-ray repair cross complementing protein 1; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human
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80. Sasieni P, Castanon A, Cuzick J: Screening and adenocarcinoma of the cervix. Int J Cancer; 2009 Aug 1;125(3):525-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Screening and adenocarcinoma of the cervix.
  • Although there can be no doubt about its effectiveness in preventing squamous-cell carcinoma, there is little evidence of any benefit on adenocarcinoma and adenosquamous carcinoma of the cervix, and many authors have concluded that it is ineffective.
  • Among 3,305 cases with known histology, 641 had adenocarcinoma and 133 adenosquamous carcinoma.
  • The risk reduction associated with 3-yearly screening was greater for squamous carcinoma (75%, 95%CI 71-79%) and adenosquamous carcinoma (83%, 95%CI 68-91%) than for adenocarcinoma (43%, 95%CI 24-58%).
  • Among stage 1B+ cases, 83% (335/406) of women with adenocarcinoma had been screened within 10 years of diagnosis.
  • This is very similar to controls (82%, 3,292/3,965), but much higher than in women with squamous carcinoma (57%, 852/1,493).
  • Incidence of adenocarcinoma was low within 2.5 years of a negative smear (OR 2.3, 95%CI 0.15-0.34), but was no different from the background rates 4.5-5.5 years after a negative smear.
  • We conclude that screening has reduced the incidence of adenocarcinoma of the cervix, but the prognostic value of cytology is less (in both magnitude and duration) for adenocarcinoma than for squamous carcinoma.
  • The impact of screening on adenosquamous carcinoma is similar to its impact on squamous carcinoma.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / prevention & control. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Adenosquamous / prevention & control. Mass Screening. Uterine Cervical Neoplasms / epidemiology. Uterine Cervical Neoplasms / prevention & control
  • [MeSH-minor] Adult. Aged. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / prevention & control. Case-Control Studies. Colposcopy. Female. Great Britain / epidemiology. Humans. Incidence. Logistic Models. Middle Aged. Neoplasm Invasiveness


81. Hsu JT, Yeh CN, Chen YR, Chen HM, Hwang TL, Jan YY, Chen MF: Adenosquamous carcinoma of the pancreas. Digestion; 2005;72(2-3):104-8
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  • [Title] Adenosquamous carcinoma of the pancreas.
  • BACKGROUND/AIMS: Adenosquamous carcinoma (ASC) of the pancreas is rare and correct preoperative diagnosis is difficult.
  • This study investigated the clinicopathological features of 7 cases of ASC of the pancreas and reviewed the pertinent literature to elucidate this rare disease.
  • CONCLUSIONS: Patients with ASC present symptoms similar to those of adenocarcinoma of the pancreas.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Pancreatic Neoplasms / pathology

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16172546.001).
  • [ISSN] 0012-2823
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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82. Pera M, Pera M, de Bolós C, Brito MJ, Palacín A, Grande L, Cardesa A, Poulsom R: Duodenal-content reflux into the esophagus leads to expression of Cdx2 and Muc2 in areas of squamous epithelium in rats. J Gastrointest Surg; 2007 Jul;11(7):869-74
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  • [Title] Duodenal-content reflux into the esophagus leads to expression of Cdx2 and Muc2 in areas of squamous epithelium in rats.
  • The molecular events responsible for the transdifferentiation of epithelial cells of the esophagus to a columnar cell type are not well understood.
  • Cdx2 has been detected in Barrett's esophagus, so we sought evidence of Cdx2 expression during the process of transdifferentiation of the esophageal squamous epithelium into a glandular phenotype.
  • Five animals developed glandular metaplasia and adenosquamous carcinoma, two developed only glandular metaplasia, and two had adenosquamous carcinoma alone.
  • Nuclear Cdx2 expression was detected in 57% (four of seven) and 43% (three of seven) of foci of glandular metaplasia and adenosquamous carcinomas, respectively.
  • Cdx2 staining was detectable in some squamous and some mucus secreting cells.
  • Perinuclear and perivacuolar staining of Muc2 was detected focally in 71% (five of seven) and 57% (four of seven) of areas with glandular metaplasia and adenosquamous carcinoma, respectively.

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  • (PMID = 17440788.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / Muc2 protein, rat; 0 / Mucin-2; 0 / Mucins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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83. Riaz N, Khan SM, Idrees R, Kayani N: Infiltrating syringomatous adenoma of nipple. J Coll Physicians Surg Pak; 2008 Jul;18(7):438-9
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  • Important differential diagnosis include nipple adenoma, tubular carcinoma and adenosquamous carcinoma.
  • Appropriate local management includes accurate diagnosis and complete excision to avoid local recurrences.

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  • (PMID = 18760070.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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84. Tsubamoto H, Wada R, Kanazawa R, Komori S, Maeda H, Hirota S, Adachi S: Neoadjuvant transarterial chemoembolization (TACE) using cisplatin with the combination of dose-dense intravenous administration of paclitaxel for the locally advanced cervical adenocarcinoma. J Clin Oncol; 2009 May 20;27(15_suppl):e16518

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoadjuvant transarterial chemoembolization (TACE) using cisplatin with the combination of dose-dense intravenous administration of paclitaxel for the locally advanced cervical adenocarcinoma.
  • : e16518 Background: Adenocarcinoma (including adenosquamous carcinoma) of the uterine cervix has a tendency to early lymph node metastasis and is resistant to radiation therapy, thus results in poor prognosis compared with squamous cell carcinoma.
  • Neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (RH) for bulky cervical adenocarcinoma seems to be an alternative therapy to primary radiation.
  • Eligible criteria were as follows: Histologically diagnosed cervical adeno or adenosquamous carcinoma with FIGO stage IB2-IVA, Age < or equal to 75, PS 0-2, given informed consent.
  • RESULTS: Enrolled patients: 22 (1998-2006), Age: median 51 (33-75), FIGO stage: IB2 (9), IIA-IIB (8), IIIB (3), IVA (2), adeno/adenosquamous: 16/6.
  • 16 of 17 received RH, and no residual malignant cells were found pathologically (pCR) in 3.
  • CONCLUSIONS: TACE with cisplatin and dose dense paclitaxel in the neoadjuvant setting is feasible and effective for cervical adenocarcinoma.

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  • (PMID = 27960760.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Li J, Zhang DC, He J, Liu XY, Mu JW, Zhang LZ: [The rule of lymph node metastasis of adenosquamous carcinoma of the lung]. Zhonghua Zhong Liu Za Zhi; 2009 Jul;31(7):524-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The rule of lymph node metastasis of adenosquamous carcinoma of the lung].
  • OBJECTIVE: To investigate the rule of lymph node metastasis of adenosquamous carcinoma of the lung.
  • METHODS: The data of 361 surgically treated patients with adenosquamous carcinoma of the lung from October 1965 to June 2003 were collected and retrospectively reviewed.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology

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  • (PMID = 19950701.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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86. Yang HX, Hou X, Lin P, Rong TH, Yang H, Fu JH: [A prognostic analysis of N0-1M0 intralobar metastatic non-small cell lung cancer]. Zhonghua Yi Xue Za Zhi; 2009 Sep 22;89(35):2486-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A prognostic analysis of N0-1M0 intralobar metastatic non-small cell lung cancer].
  • OBJECTIVE: To assess whether it is reasonable to downgrade intralobar metastatic non-small cell lung cancer from T4 disease through a prognostic analysis of N0-1M0 disease.
  • METHODS: A retrospective analysis was conducted to assess the survival of patients with intralobar metastatic non-small cell lung cancer with pathological N0-1M0 disease.
  • The median survival was 24.0 months for patients with adenosquamous carcinoma; while for patients with other pathologic types, the median survival was 48 months.
  • Adenosquamous carcinoma had a shorter survival time than other pathologic types (P = 0.003).
  • CONCLUSION: It is reasonable to downgrade the T4 classification of non-small cell lung cancer with intralobar metastasis.
  • Adenosquamous carcinoma has a poor prognosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology


87. Rossi G, Sartori G, Cavazza A, Tamberi S: Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis. Lung Cancer; 2009 Jan;63(1):159-60
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  • [Title] Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis.
  • Mucoepidermoid carcinoma (MEC) of the lung needs to be carefully distinguished from other lung tumors with similar features, particularly from adenosquamous carcinoma, this latter tumor frequently showing EGFR mutations.
  • [MeSH-major] Carcinoma, Mucoepidermoid / drug therapy. Carcinoma, Mucoepidermoid / genetics. Genes, ras. Lung Neoplasms / drug therapy. Lung Neoplasms / genetics. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Aged. Diagnosis, Differential. Epithelium / metabolism. Female. Humans. Keratins / metabolism. Mucin 5AC / metabolism. Mucins / metabolism. Mutation

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  • [CommentOn] Lung Cancer. 2008 Jul;61(1):30-4 [18192072.001]
  • (PMID = 18992960.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins; 68238-35-7 / Keratins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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88. Kobayashi N, Higurashi T, Iida H, Mawatari H, Endo H, Nozaki Y, Tomimoto A, Yoneda K, Akiyama T, Fujita K, Takahashi H, Yoneda M, Inamori M, Abe Y, Kirikoshi H, Kubota K, Saito S, Ueno N, Nakajima A, Yamanaka S, Inayama Y: Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM). J Hepatobiliary Pancreat Surg; 2008;15(5):531-5
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  • [Title] Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM).
  • We report a rare case of adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) was identified as the causative factor of hypercalcemia.
  • Autopsy demonstrated that the neoplasm in the pancreas showed an abrupt histological transition from adenocarcinoma to squamous cell carcinoma.
  • PTH-rP was identified in the primary pancreatic tumor cells by immunohistochemical examination and a reverse-transcription polymerase chain reaction (RTPCR) method.
  • This is a very rare report of adenosquamous cell carcinoma of the pancreas associated with HHM.
  • [MeSH-major] Carcinoma, Adenosquamous / complications. Hypercalcemia / etiology. Pancreatic Neoplasms / complications

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  • (PMID = 18836809.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein
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89. Katz SL, Das P, Ngan BY, Manson D, Pappo AS, Sweezey NB, Solomon MP: Remote intrapulmonary spread of recurrent respiratory papillomatosis with malignant transformation. Pediatr Pulmonol; 2005 Feb;39(2):185-8
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  • [Title] Remote intrapulmonary spread of recurrent respiratory papillomatosis with malignant transformation.
  • Extension into lung parenchyma occurs in less than 1% of patients and has a low risk of malignant transformation.
  • We describe a case of recurrent respiratory papillomatosis with extensive parenchymal involvement and adenosquamous carcinoma in a 14-year-old girl.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Cell Transformation, Neoplastic. Laryngeal Neoplasms / pathology. Lung Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Papilloma / pathology
  • [MeSH-minor] Adolescent. Biopsy, Needle. Combined Modality Therapy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 15532092.001).
  • [ISSN] 8755-6863
  • [Journal-full-title] Pediatric pulmonology
  • [ISO-abbreviation] Pediatr. Pulmonol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Kim KW, Kim SH, Kim MA, Lee JM, Park HS, Kim JY, Lee JY, Han JK, Choi BI: Adenosquamous carcinoma of the extrahepatic bile duct: clinicopathologic and radiologic features. Abdom Imaging; 2009 Mar-Apr;34(2):217-24
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  • [Title] Adenosquamous carcinoma of the extrahepatic bile duct: clinicopathologic and radiologic features.
  • BACKGROUND: To retrospectively analyze computed tomography (CT) features of adenosquamous carcinoma (ASC) of the extrahepatic bile duct and to correlate them with pathologic findings.
  • Histologically, ASC was composed of squamous and glandular components which mixed in an intermingled pattern and was characterized by a high local aggressiveness mainly due to the squamous component.
  • However, their CT findings are not quite different from those of usual adenocarcinoma due to the unique geographic characteristic of being located at a very limited space.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Duct Neoplasms / radiography. Bile Ducts, Extrahepatic. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiography. Tomography, X-Ray Computed

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  • (PMID = 18204917.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Hsu JT, Chen HM, Wu RC, Yeh CN, Yeh TS, Hwang TL, Jan YY, Chen MF: Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma. World J Surg Oncol; 2008;6:95
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  • [Title] Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma.
  • BACKGROUND: Pancreatic adenosquamous carcinoma (ASC) is a rare pancreatic malignancy subtype.
  • Survival data of patients with stage IIB pancreatic adenocarcinoma and ASC undergoing surgical resection were compared.
  • Patients with stage IIB pancreatic ASC had shorter median survival compared to those with adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery

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  • [Cites] Obstet Gynecol. 1963 Nov;22:578-82 [14082276.001]
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  • (PMID = 18764955.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2543014
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92. Yi L, Yang LY, Wang YH: [Diagnosis and treatment of rare mixed prostatic carcinoma]. Zhonghua Nan Ke Xue; 2009 Aug;15(8):727-9
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  • [Title] [Diagnosis and treatment of rare mixed prostatic carcinoma].
  • OBJECTIVE: To discuss the diagnosis and treatment of rare mixed prostatic carcinoma.
  • METHODS: We retrospectively analyzed the clinical data of 6 cases of mixed prostatic tumor confirmed by surgery or transrectal ultrasound guided prostate biopsy, and reviewed the related literature.
  • RESULTS: Three of the patients (2 with mixed small cell carcinoma and adenocarcinoma and 1 with adenosquamous carcinoma of the prostate) underwent palliative transurethral electrovaporization of the prostate (TUVP) and endocrine therapy, but all died within 7 - 10 months.
  • The other 3 (2 with adenosquamous carcinoma and 1 with carcinosarcoma of the prostate) received cystoprostatectomy, urinary diversion, pelvic lymphadenectomy and radiation therapy, and survived for more than 12 months, with 2 of them still under the follow-up observation.
  • CONCLUSION: Mixed prostatic carcinoma behaves aggressively with poor prognosis, of which the diagnosis relies on meticulous pathological examination and immunohistochemical techniques, and the most effective treatment is radical surgery.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / surgery. Carcinosarcoma / diagnosis. Carcinosarcoma / surgery. Prostatic Neoplasms / diagnosis. Prostatic Neoplasms / surgery

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  • (PMID = 19852276.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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93. Suárez-Peñaranda JM, Vieites B, Valeiras E, Varela-Duran J: Primary mucoepidermoid carcinoma of the skin expressing p63. Am J Dermatopathol; 2010 Feb;32(1):61-4
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  • [Title] Primary mucoepidermoid carcinoma of the skin expressing p63.
  • Primary mucoepidermoid carcinoma (MEC) of the skin is an unusual neoplasm with few cases reported in the English medical literature.
  • It has to be differentiated from adenosquamous carcinoma, usually a high-grade neoplasm with poorer outcome, and metastasis from a primary MEC arising elsewhere in the body.
  • Histopathological examination revealed a dermal located carcinoma with variable proportions of squamous differentiation and goblet cells.
  • The patient died in a very short time for an unrelated disease.
  • Immunohistochemical study showed staining for cytokeratins (AE1AE3, 7, and 34betaE12), epithelial membrane antigen (EMA), and p63, whereas cytokeratins 18 and 20 and gross cystic disease fluid protein (GCDFP15) were negative.
  • We conclude that primary MEC of the skin is usually a slow-growing neoplasm that should be differentiated from adenosquamous carcinoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Mucoepidermoid / metabolism. Skin Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Aged. Carcinoma, Adenosquamous / diagnosis. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Keratins / metabolism. Leiomyosarcoma / secondary. Liver Neoplasms / secondary. Neoplasms, Multiple Primary. Peritoneal Neoplasms / secondary. Transcription Factors

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  • (PMID = 19786853.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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94. Akatsu T, Kameyama K, Kawachi S, Tanabe M, Aiura K, Wakabayashi G, Ueda M, Shimazu M, Kitajima M: Gallbladder carcinoma with osteoclast-like giant cells. J Gastroenterol; 2006 Jan;41(1):83-7
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  • [Title] Gallbladder carcinoma with osteoclast-like giant cells.
  • Recently, some authors have suggested that carcinomas containing OGCs may represent a distinct clinicopathological entity with a more favorable prognosis.
  • We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs.
  • Histological examination showed an adenosquamous carcinoma with an infiltrate of benign OGCs.
  • This case adds to a small body of literature on gallbladder carcinoma with OGCs.
  • Further studies are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma) with those cells.
  • [MeSH-major] Carcinoma, Adenosquamous / pathology. Gallbladder Neoplasms / pathology. Giant Cells / pathology. Osteoclasts / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Prognosis

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  • (PMID = 16501862.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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95. Lada PE, Taborda B, Sánchez M, Tommasino J, Rosso FF, Gramática L, Alecha Gil J, Echenique Elizondo M: [Adenosquamous and squamous carcinoma of the gallbladder]. Cir Esp; 2007 Apr;81(4):202-6
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  • [Title] [Adenosquamous and squamous carcinoma of the gallbladder].
  • [Transliterated title] Carcinoma adenoescamoso y epidermoide de la vesícula biliar.
  • INTRODUCTION: Squamous and adenosquamous carcinomas of the gallbladder have poor prognosis.
  • MATERIAL AND METHOD: We performed a retrospective observational study of five patients with squamous or adenosquamous carcinoma of the gallbladder.
  • None of the patients had jaundice and all had gallstone disease.
  • Pathologic analysis revealed epidermoid carcinoma in two patients and adenosquamous carcinoma in three patients.
  • CONCLUSIONS: In both histological types of gallbladder carcinoma, treatment depends on the grade of local and regional invasion and tumor spread at diagnosis.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 17403356.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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96. Sasaki H, Endo K, Yukiue H, Kobayashi Y, Yano M, Fujii Y: Mutation of epidermal growth factor receptor gene in adenosquamous carcinoma of the lung. Lung Cancer; 2007 Jan;55(1):129-30
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  • [Title] Mutation of epidermal growth factor receptor gene in adenosquamous carcinoma of the lung.
  • We have investigated 26 adenosquamous lung cancer tissues and found that four EGFR mutations were mainly in female and non-smoker lung cancer.
  • [MeSH-major] Carcinoma, Adenosquamous / genetics. Lung Neoplasms / genetics. Mutation. Receptor, Epidermal Growth Factor / genetics

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  • [CommentOn] Lung Cancer. 2006 Apr;52(1):47-52 [16503085.001]
  • (PMID = 17156891.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Comment; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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97. Yokota H, Matoba M, Tonami H, Hasegawa T, Saito H, Kurose N: Imaging findings in primary adenosquamous carcinoma of the liver: a case report. Clin Imaging; 2007 Jul-Aug;31(4):279-82
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  • [Title] Imaging findings in primary adenosquamous carcinoma of the liver: a case report.
  • Adenosquamous cell carcinoma is characterized by both squamous and glandular components, and is a rare disease of the liver that is the subject of few reports in the literature.
  • We present a case in which the imaging findings on CT, MRI, and hepatic arteriography, as well as pathological correlation of the tumor and the clinical history, aided in including this entity in the differential diagnosis.
  • [MeSH-major] Carcinoma, Adenosquamous / radiography. Liver Neoplasms / radiography. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17599625.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Ravn T, Trolle W, Kiss K, Balle VH: Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. Auris Nasus Larynx; 2009 Dec;36(6):721-4

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  • [Title] Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge.
  • This, as well as the histopathologic findings of necrotizing sialometaplasia, can be confused with those of a malignant neoplasm.
  • We report a rare case of necrotizing sialometaplasia in the larynx, probably initiated by an underlying malignant process.
  • [MeSH-major] Carcinoma, Adenosquamous / diagnosis. Laryngeal Diseases / diagnosis. Laryngeal Neoplasms / diagnosis. Sialometaplasia, Necrotizing / diagnosis
  • [MeSH-minor] Adult. Biopsy. Comorbidity. Diagnosis, Differential. Epiglottis / pathology. Female. Humans. Hypopharynx / pathology. Laryngoscopy. Magnetic Resonance Imaging. Neoplasm Invasiveness. Vocal Cords / pathology

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  • (PMID = 19482450.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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99. Vrdoljak E, Omrcen T, Novaković ZS, Jelavić TB, Prskalo T, Hrepić D, Hamm W: Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy for women with locally advanced carcinoma of the uterine cervix--final results of a prospective phase II-study. Gynecol Oncol; 2006 Nov;103(2):494-9
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  • [Title] Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy for women with locally advanced carcinoma of the uterine cervix--final results of a prospective phase II-study.
  • OBJECTIVES: To evaluate the efficacy and toxicity of ifosfamide and cisplatin administered concomitantly with low-dose rate brachyradiotherapy followed by consolidation chemotherapy in the treatment of locally advanced squamous cell carcinoma (LASCC) or adeno/adenosquamous carcinoma of the uterine cervix.
  • The patients had to have FIGO-stage IB2 bulky to IVA disease, biopsy-proven squamous cell or adeno/adenosquamous carcinoma of the uterine cervix.
  • CONCLUSION: These results indicate that concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy with the same drug combination is a highly efficacious and very promising treatment protocol for patients with locally advanced LASCC or adeno/adenosquamous carcinoma of the uterine cervix.
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Disease-Free Survival. Dose Fractionation. Drug Administration Schedule. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / adverse effects. Middle Aged. Neoplasm Staging. Prospective Studies


100. Kinkor Z, Skálová A, Michal M, Janousek M, Kheck M: [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. Ceska Gynekol; 2005 May;70(3):211-6
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  • [Title] [Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature].
  • [Transliterated title] Metastazující a recidivující "low grade" adenoskvamózní metaplastický karcinom prsu--jde skutecnĕ o indolentní lezi? Popis trí prípadů a rozbor literatury.
  • OBJECTIVE: To describe personnel experience with three unusual cases of low-grade adenosquamous carcinoma of the breast.
  • Due to the aggressive course in two cases, the review of the literature does not concentrate on morphology and differential diagnosis only, but discuss overall biology of this lesion too.
  • Histology revealed low-grade adenosquamous metaplastic carcinoma displaying typical biphasic appearance combining regular tubular structures with surrounding storiform, sclerosing fibrous stroma.
  • Variably present was characteristic squamous metaplasia of the gland forming either luminal morules or evident squamous pearls.
  • CONCLUSION: low-grade adenosquamous carcinoma, despite its bland histology, should be understood as regular malignancy prone to frequent recurrences and recognized metastatic potential.
  • It arises in the deep breast tissue and structurally resembles the microcystic adnexal carcinoma of the skin.
  • Low-grade adenosquamous carcinoma, however, has nothing to do with syringomatous adenoma of the nipple, which is a benign tumor of the skin adnexa.
  • Differential diagnosis includes spectrum of non-neoplastic slerosing lesions and above-mentioned phylloid tumor.

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  • (PMID = 16047925.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 12
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