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1. Freeman HJ: Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction. World J Gastroenterol; 2005 Sep 7;11(33):5245-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction.
  • Endoscopy showed a large polyp on a stalk, protruding through the pylorus into the duodenum causing intermittent gastric outlet obstruction.
  • While prolapsing gastric antral polyps are usually benign and hyperplastic, inflammatory or regenerative in type, excisional snare polypectomy here led to complete resolution of his symptoms, but showed a malignant polyp.
  • [MeSH-major] Adenomatous Polyps / complications. Adenomatous Polyps / surgery. Gastric Outlet Obstruction / etiology. Gastroscopy. Stomach Neoplasms / complications. Stomach Neoplasms / surgery

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  • (PMID = 16127764.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320407
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2. Beaton MD, Taylor B, Driman D, Ainsworth P, Adams PC: Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation? Can J Gastroenterol; 2008 Jul;22(7):634-6
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  • [Title] Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation?
  • Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps.
  • While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colonic Polyps / pathology

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  • (PMID = 18629394.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2661270
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3. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA: Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol; 2007 Jan-Mar;44(1):14-7
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  • [Title] Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies.
  • BACKGROUND: Gastric polyps are small gastric lesions, asymptomatic in most cases and are generally discovered inadvertently during upper digestive endoscopy.
  • AIM: To retrospectively review the characteristics and frequency of gastric polyps, derived from the gastric mucosal epithelium in a large series of endoscopies.
  • All patients had at least one gastric polyp, as confirmed by histological examination.
  • RESULTS: The polyps were classified as hyperplastic, adenomatous and fundic gland polyps.
  • The most of them measure less than 1 cm (hyperplastic polyps - 60,5%; adenomatous polyps - 73,6%; fundic gland polyps - 72%).
  • Hyperplastic polyps were the most frequent and accounted for 71.3% of the cases, whereas fundic gland polyps accounted for 16.3% and adenomatous polyps for 12.4%.
  • Hyperplastic and adenomatous polyps were primarily single, whereas fundic gland polyps tended to be multiple.
  • A carcinoma was detected in one hyperplastic polyp (0.9%) and in two adenomatous polyps (10.5%).
  • High grade dysplastic foci were found in four adenomatous polyps (21%).
  • CONCLUSIONS: The digestive endoscopy is the safest and efficient method for the diagnosis of the gastric polyps, that in most of the patients does not show characteristic symptoms.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Adult. Aged. Aged, 80 and over. Female. Gastric Fundus. Gastroscopy. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 17639176.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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4. Oh SY, Park DI, Yoo TW, Kang MS, Kim SH, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Son BH, Yoo CH: [Is gastric cancer a new indication for surveillance colonoscopy? Colon cancer is increased in gastric cancer patients]. Korean J Gastroenterol; 2006 Mar;47(3):191-7
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  • [Title] [Is gastric cancer a new indication for surveillance colonoscopy? Colon cancer is increased in gastric cancer patients].
  • BACKGROUND/AIMS: It has been reported that the risk of gastric polyp is increased in various colonic polyposis syndromes or in series of patients with sporadic colonic polyps.
  • However, there are only a few large case controlled studies of colon cancer incidence in gastric cancer patients who underwent colonoscopy.
  • The aims of this study were to determine the incidence of colorectal neoplasm and to evaluate the necessity of colonoscopic surveillance in patients with gastric cancer.
  • METHODS: We performed colonoscopy in 105 patients with gastric cancer who agreed to undergo colonoscopy before or after 6 months from gastric resection between January 2002 and December 2004 in Kangbuk Samsung hospital.
  • As a control group, 269 consecutive, age and sex matched patients without gastric neoplasm on gastroscopy who underwent colonoscopy within 6 months for the evaluation of various gastrointestinal symptoms during the year 2004 were included.
  • RESULTS: In the patient group, adenomatous polyps were diagnosed in 24/105 patients (22.9%) and colorectal adenocarcinoma in 10/105 patients (9.5%).
  • In the control group, adenomatous polyps were diagnosed in 78/269 patients (29.0%) and colorectal adenocarcinoma in 2/269 patients (0.7%).
  • CONCLUSIONS: The risk of colorectal adenocarcinoma increases significantly in patients with gastric cancer.
  • We suggest that the patients with gastric cancer might carry a high risk for colorectal cancer whom require surveillance colonoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 16554672.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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5. Stănciulea O, Preda C, Herlea V, Popa M, Ulmeanu D, Vasilescu C: [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis]. Chirurgia (Bucur); 2007 Mar-Apr;102(2):215-20
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  • [Title] [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis].
  • We present the case of a 52 years old man, with significant familial history, diagnosed with familial adenomatous polyposis-attenuated form, with no clinical and endoscopic surveillance until 2001 when he was admitted for an upper gastrointestinal haemorrhage episode.
  • Upper gastrointestinal scopy revealed duodenal adenomatous polyps and gastric hyperplastic polyps.
  • The histopathological exam revealed duodenal G2 adenocarcinoma pT3N0, and gastric hyperplastic polyps with no signs of dysplasia.
  • In 2002 the patient was admitted for rectal bleeding and colonoscopy showed 2 sigmoid polyps, appropriate for endoscopic removal and a poly-lobate polyp in the transverse colon.
  • March 2003--the patient underwent endoscopic removal for a rectal polyp (histopathological exam: moderate dysplasia).
  • The surgical procedure recommended in patients with attenuated form of familial adenomatous polyposis and suspect periampullary lesions is duodenopancreatectomy.
  • The particularity of the case is the association of total gastrectomy for gastric hyperplastic polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Carcinoma / surgery. Duodenal Neoplasms / surgery. Gastrectomy. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Ampulla of Vater. Humans. Male. Middle Aged. Stomach Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17615925.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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6. Bianchi LK, Burke CA, Bennett AE, Lopez R, Hasson H, Church JM: Fundic gland polyp dysplasia is common in familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2008 Feb;6(2):180-5
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  • [Title] Fundic gland polyp dysplasia is common in familial adenomatous polyposis.
  • BACKGROUND & AIMS: Fundic gland polyps (FGPs) are common in familial adenomatous polyposis (FAP) but have been considered nonneoplastic.
  • Gastric carcinoma arises from FGPs in FAP presumably from a dysplasia-carcinoma pathway.
  • FGP dysplasia is associated with larger polyp size, increased severity of duodenal polyposis, and antral gastritis.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / pathology. Gastric Fundus / pathology. Precancerous Conditions / epidemiology. Precancerous Conditions / pathology. Pyloric Antrum / pathology. Stomach Neoplasms

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  • (PMID = 18237868.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Neneman B, Gasiorowska A, Małecka-Panas E: The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon. Adv Med Sci; 2006;51:88-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon.
  • The aim of the study was to assess the outcome and safety of argon plasma coagulation (APC) in the management of gastric and colorectal polyp remnants after polypectomy, and to search for clinical parameters useful in predicting the efficacy of this technique.
  • MATERIAL AND METHODS: This prospective study comprised 18 patients with gastric polyps and 29 with colonic polyps found in upper and lower GI endoscopy.
  • Overall 22 gastric polyps and 58 colonic polyps have been detected.
  • All those polyps were removed at colonoscopy with the diathermic snare and the polyp remnants were destroyed with APC using Argon Beamer source (Erbe, Germany).
  • RESULTS: Pathologic examination revealed 10 hyperplastic polyps and 12 tubular adenomas of the stomach.
  • Effective destruction of polyp remnants was achieved in 20 (90.9%) gastric polyps in 16 (88.9%) patients.
  • Significant positive correlation was demonstrated between the power output, APC sessions number and polyp location in the prepyloric part, its size and adenomatous content.
  • Effective destruction of remnant polyp tissue was obtained in 56 (96.4%) polyps in 27 (93.1%) patients.
  • A significant positive correlation between the power output and the size, distal location and villous texture of the polyp has been demonstrated.
  • CONCLUSIONS: APC is an effective and safe method in the management of polyp remnants in the stomach and colon.
  • The application of higher electric power and numerous APC sessions are necessary to remove residues of large gastric polyps located in the prepyloric part and of with adenomatous content.
  • [MeSH-major] Colonic Polyps / surgery. Electrocoagulation / methods. Neoplasm, Residual / surgery. Stomach Neoplasms / surgery

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  • (PMID = 17357283.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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8. Fujimura T, Ohta T, Oyama K, Miyashita T, Miwa K: Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. World J Gastroenterol; 2006 Mar 7;12(9):1336-45

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  • After performing a randomized study for polyp chemoprevention study in patients with familial adenomatous polyposis (FAP),which showed that the treatment with celecoxib, one of the coxibs, significantly reduced the number of colorectal polyps in 2000, the U.S.
  • In this article we review a role of COX-2 in carcinogenesis of gastrointestinal tract, such as the esophagus, stomach and colorectum,and also analyze the prospect of coxibs for chemoprevention of gastrointestinal tract tumors.
  • [MeSH-minor] Adenomatous Polyposis Coli / drug therapy. Cardiovascular Diseases / chemically induced. Cardiovascular Diseases / physiopathology. Cell Proliferation / drug effects. Colorectal Neoplasms / etiology. Colorectal Neoplasms / prevention & control. Cyclooxygenase 2 Inhibitors / adverse effects. Cyclooxygenase 2 Inhibitors / pharmacology. Cyclooxygenase 2 Inhibitors / therapeutic use. Dinoprostone / metabolism. Esophageal Neoplasms / etiology. Esophageal Neoplasms / prevention & control. Humans. Intestinal Mucosa / chemistry. Intestinal Mucosa / metabolism. RNA, Messenger / analysis. Risk Factors. Stomach Neoplasms / etiology. Stomach Neoplasms / prevention & control

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  • (PMID = 16552798.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / RNA, Messenger; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
  • [Number-of-references] 92
  • [Other-IDs] NLM/ PMC4124307
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9. Mandir N, Goodlad RA: Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer. Cell Prolif; 2008 Apr;41(2):279-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer.
  • MATERIALS AND METHODS: The effects of the predominant forms of CLA, namely the c9t11 and t10c12 isomers, or a mixture of these on polyp development, were investigated in the Apc(Min/+) mouse.
  • RESULTS: The stomach and small intestine were significantly heavier in the t10c12, and in the mixture-treated groups (P < 0.001).
  • The t10c12 and the mixture significantly reduced polyp number in the proximal small intestine but they increased polyp diameter in the middle and distal small intestine, to an extent that the polyp burden was significantly increased at these sites.
  • All CLAs significantly reduced polyp number in the colon, but the mixture significantly increased polyp diameter in the colon.
  • CONCLUSION: Increased polyp diameter associated with t10c12 diet and especially with the mixture is a cause of concern, as this is the commercially available form.
  • The naturally occurring isomer, c9t11 decreased colonic polyp number and did not increase diameter, suggesting that this natural isomer is the most likely to be protective.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Intestinal Neoplasms / prevention & control. Intestinal Polyps / drug therapy. Linoleic Acids, Conjugated / administration & dosage

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  • (PMID = 18336472.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Linoleic Acids, Conjugated; 0 / beta Catenin; 0 / cis-9, trans-11-conjugated linoleic acid; 0 / trans-10,cis-12-conjugated linoleic acid
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10. Sotnikov VN, Dubinskaia TK, Sotnikov AV, Ageĭkina NV, Margarian LA, Vyshegurov KhKh: [Polyposis of the stomach. Endoscopic treatment or follow-up?]. Khirurgiia (Mosk); 2007;(1):38-42
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Polyposis of the stomach. Endoscopic treatment or follow-up?].
  • Out of 3243 patients with gastric polips, polyposis was diagnosed in 298 ones including 135 cases of complicated and 163 cases of uncomplicated forms.
  • There were no cases of polyp transformation into cancer.
  • [MeSH-major] Endoscopy. Polyps. Stomach Neoplasms
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hyperplasia. Male. Middle Aged. Peutz-Jeghers Syndrome / diagnosis. Peutz-Jeghers Syndrome / pathology. Reoperation. Stomach / pathology. Time Factors

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  • (PMID = 17426688.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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11. Goddard AF, Badreldin R, Pritchard DM, Walker MM, Warren B, British Society of Gastroenterology: The management of gastric polyps. Gut; 2010 Sep;59(9):1270-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The management of gastric polyps.
  • BACKGROUND: Gastric polyps are important as some have malignant potential.
  • If such polyps are left untreated, gastric cancer may result.
  • The malignant potential depends on the histological type of the polyp.
  • DEFINITION: Gastric polyps are sessile or pedunculated lesions that originate in the gastric epithelium or submucosa and protrude into the stomach lumen.
  • MALIGNANT POTENTIAL: Depending on histological type, some gastric polyps (adenomas and hyperplastic polyps) have malignant potential and are precursors of early gastric cancer.
  • They may also indicate an increased risk of intestinal or extra-intestinal malignancy.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Evidence-Based Medicine / methods. Gastroscopy / methods. Humans. Precancerous Conditions / diagnosis. Precancerous Conditions / surgery. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery

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  • (PMID = 20675692.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Review
  • [Publication-country] England
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12. Kawase R, Nagata S, Onoyama M, Nakayama N, Honda Y, Kuwahara K, Kimura S, Tsuji K, Ohgoshi H, Sakatani A, Kaneko M, Ito M, Shimamoto F, Hidaka T: A case of gastric adenocarcinoma arising from a fundic gland polyp. Clin J Gastroenterol; 2009 Aug;2(4):279-283

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of gastric adenocarcinoma arising from a fundic gland polyp.
  • A rare case of gastric adenocarcinoma arising on the surface of a fundic gland polyp is reported.
  • A 36-year-old Japanese woman was referred to our hospital for examination and treatment of a polyp that had been detected in another hospital.
  • She did not have a history of familial adenomatous polyposis (FAP).
  • Endoscopic examination revealed a 10-mm-diameter fundic gland polyp in the body of the stomach.
  • The polyp had an irregular depression on its top, suggesting the presence of malignancy.
  • Endoscopic mucosal resection was done to make a histological diagnosis.
  • This revealed a fundic gland polyp with a tiny superficial adenocarcinoma.
  • Atrophic changes of the gastric mucosa were mild, although Helicobacter pylori infection was positive.

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  • [Cites] Clin Gastroenterol Hepatol. 2008 Feb;6(2):180-5 [18237868.001]
  • [Cites] Gut. 2002 Nov;51(5):742-5 [12377817.001]
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  • (PMID = 26192425.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Adenocarcinoma / Fundic gland polyp / Helicobacter pylori
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13. Rocha Ramírez JL, Villanueva Sáenz E, Hernández-Magro PM, Sierra Montenegro E, Soto Quirino R, Pérez Aguirre J, Blanco Lemus E: [Hereditary mixed polyposis syndrome. First report in Mexico]. Rev Gastroenterol Mex; 2005 Oct-Dec;70(4):430-3

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  • CASE REPORT: Male patient, 38 years old, with familiar antecedent (dead sister) with polyps and gastric cancer.
  • At blood test with hemoglobin of 9.7 g/dL, and colonoscopy with multiple polyps within colon and rectum, upper endoscopy with a big esophageal polyp and multiple polyps in gastric and duodenal lining smaller than 1 cm.
  • Histopathologic study of the polyps report mixed pattern of polyps: (hyperplasic-adenomatous, juvenile-adenomatous, adenoma-inflammatory-hyperplasic, hyperplasic-adenomatous with a high degree dysplasia); juvenile in esophagus, and hyperplasic in stomach and duodenum.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis

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  • (PMID = 17058983.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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14. Farah Klibi F, Ferchichi L, Borgi C, Jemaa Y, Najjar T, Ben Jilani S, Zermani R: [Histopathological study of gastric polyps. A report of 65 cases]. Tunis Med; 2006 Oct;84(10):611-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Histopathological study of gastric polyps. A report of 65 cases].
  • In a retrospective study of the specimens of gastric polypectomy, carried out between January 1992 and December 2002, we analysed the demographic and histological aspects of 65 polyps.
  • This study revealed hyperplastic polyps in 66%, adenomatous lesions in 9.2%, Peutz-Jeghers polyps in 7.7%, inflammatory fibroid polyps in 6.15%, two cases of focal foveolar hyperplasia (3%), two cases of Brunner's gland heterotopia (3%), 1 pancreatic heterotopia (1.5%), 1 fundic gland polyp (1.5%) and 1 carcinoid tumor (1.5%).
  • Other lesions were found within the polyps or into the surrounding gastric mucosa, such as intestinal metaplasia and Helicobacter Pylori gastritis.
  • This work allowed us to recommend complete removal of gastric polyps and the realization of biopsies of the nonpolypoid gastric mucosa in the search of intraepithelial neoplasia or other lesions with malignant potential.
  • [MeSH-major] Adenomatous Polyps / pathology. Carcinoid Tumor / pathology. Cell Transformation, Neoplastic / pathology. Peutz-Jeghers Syndrome / pathology. Polyps / pathology. Stomach / pathology. Stomach Diseases / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brunner Glands. Choristoma / pathology. Gastric Mucosa / pathology. Gastritis / pathology. Gastritis / virology. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Hyperplasia / pathology. Middle Aged. Pancreas. Retrospective Studies

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  • (PMID = 17193851.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Tunisia
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15. Kobak AC, Zeybel M, Ayhan S, Aydin A, Kaya Y, Ellidokuz E: Gastric polypoid intramucosal carcinoma and an adjacently located leiomyoma at the cardia. Turk J Gastroenterol; 2008 Jun;19(2):114-6
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  • [Title] Gastric polypoid intramucosal carcinoma and an adjacently located leiomyoma at the cardia.
  • We report a 65-year-old patient with a gastric polyp of 2.5 cm in diameter located at the cardia on upper gastrointestinal (GI) endoscopy.
  • Pathological examination of the excised polyp showed intramucosal carcinoma.
  • Endoscopic ultrasonography (EUS) reported the lesion as early gastric carcinoma with probable submucosal involvement.
  • [MeSH-major] Carcinoma / diagnosis. Gastric Mucosa / pathology. Leiomyoma / diagnosis. Neoplasms, Second Primary / diagnosis. Polyps / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Aged. Cardia / pathology. Cardia / surgery. Diagnosis, Differential. Endoscopy, Digestive System / methods. Endosonography. Female. Gastrectomy. Humans

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  • (PMID = 19110667.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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16. Frazzetta M, Raimondo D, Furgiuele G, Sammartano A, Romito F, Frazzetta F, Lucania M, Piccolo CL, Bonventre S: Gastric polypoid lesions. Our experience. G Chir; 2010 Apr;31(4):162-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric polypoid lesions. Our experience.
  • BACKGROUND AND AIM: The Authors report the results of their experience on polypoids lesions of the stomach and on endoscopic polypectomies.
  • The authors have analysed the associations existing between histological type and symptomatology and localisation of the lesion and the status of the Helicobacter pylori and the risk of cancerization.
  • RESULTS: In the majority of the cases, the polypoid lesions were asymptomatic, the localization changed according to the histological type, with the antrum as the most affected area.
  • The percentage of risks of cancerization increased in case of adenomatous polyps.
  • In one patient signet ring cell carcinoma within a gastric polyp was found.
  • Gastric signet ring cell carcinomas are peculiar for their rarity as well as for the growth in polypoid lesions.
  • CONCLUSION: We confirm the higher frequency of hyperplastic polyps and the correlation between histological type and localization.
  • Endoscopic polipectomy is the first approach in gastric polyps, with lower risk of developing cancer.
  • [MeSH-major] Polyps / surgery. Stomach Diseases / surgery

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  • (PMID = 20444334.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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17. Pârlog G, Murărescu D, Ungureanu C, Danciu M, Mihailovici MS: [Histopathologic and immunohistochemic changes in Helicobacter pylori colonised gastric mucosa]. Rev Med Chir Soc Med Nat Iasi; 2010 Jul-Sep;114(3):813-7
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  • [Title] [Histopathologic and immunohistochemic changes in Helicobacter pylori colonised gastric mucosa].
  • Helicobacter pylori (H. pylori) colonize gastric mucosa causing both inflammatory changes, premalignant lesions and malignant tumors, including gastric lymphoma and carcinoma.
  • In this study, our propose was to evaluate the histopathological changes corellated with immunohistochemical results demonstrating the types of cellular infiltration and proliferative activity of gastric mucosa infected with H. pylori.
  • MATERIAL AND METHOD: Gastric endoscopic examinations was performed in 468 patients with anti-H. pylori antibodies and dispeptic phenomena.
  • Snippets harvested endobiopsic stomach were fixed in formalin and processed by paraffine inclusion.
  • In 65 cases of endobiopsic fragments (36 deep chronic gastritis with intestinal metaplasia, glandular atrophy and intraepithelial neoplasia and 29 carcinomas) immunohistochemical reactions were performed by applying reagents for evidence of H. pylori colonies, of T lymphocytes (CD3) and macrophages (CD68) and Ki-67 reagent for proliferating nuclear antigen labelling.
  • Histologically, were diagnosed : 463 superficial and deep chronic gastritis associated with premalignant lesions, 29 carcinomas, 2 non-Hodgkin's lymphoma and an adematous polyp.
  • CONCLUSIONS: In gastric infection with H. pylori, inflammatory infiltrat is composed of abundant macrophages and T lymphocytes.
  • Medical eradication of bacteria may cancel inflammatory changes, metaplasia and proliferation of gastric mucosa and thus it prevents the cascade of carcinogenesis.
  • [MeSH-major] Gastric Mucosa / microbiology. Gastric Mucosa / pathology. Helicobacter Infections / pathology. Helicobacter pylori
  • [MeSH-minor] Adenomatous Polyps / microbiology. Adenomatous Polyps / pathology. Biopsy. Carcinoma / microbiology. Carcinoma / pathology. Cohort Studies. Female. Gastritis / microbiology. Gastritis / pathology. Gastroscopy. Humans. Immunohistochemistry. Lymphoma / microbiology. Lymphoma / pathology. Male. Middle Aged. Stomach Neoplasms / microbiology. Stomach Neoplasms / pathology

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  • (PMID = 21243808.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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18. Brazowski E, Rozen P, Misonzhnick-Bedny F, Gitstein G: Characteristics of familial juvenile polyps expressing cyclooxygenase-2. Am J Gastroenterol; 2005 Jan;100(1):130-8
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  • OBJECTIVES: Familial juvenile polyposis (FJP) is a dominant genetic disorder characterized by colorectal, gastric, and small bowel juvenile polyps, and high risk for gastrointestinal cancer.
  • METHODS: A total of 115 colorectal and 6 gastric polyps were available from 17 FJP patients.
  • Comparison tissues were 18 sporadic juvenile colorectal polyps, 6 gastric hyperplastic polyps, 9 normal colons, and 3 colorectal cancers (CRCs).
  • Epithelial and stromal scores (0-9) and total scores (0-18) were evaluated in relationship to patient's age, polyp site, size, dysplasia, and stromal cellularity.
  • RESULTS: Colonic FJP polyps mean total COX-2 score was 10.3 +/- 6.0, and that of sporadic juvenile polyps 3.6 +/- 2.2 (p < 0.01), and in contrast to the latter, FJP COX-2 scores increased significantly (p < 0.01) with polyp size.
  • COX-2 total scores of gastric FJP polyps and hyperplastic polyps were similar.
  • [MeSH-major] Adenomatous Polyposis Coli / enzymology. Colonic Polyps / enzymology. Isoenzymes / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Cyclooxygenase 2. Epithelial Cells / metabolism. Humans. Membrane Proteins. Stomach Neoplasms / enzymology. Stomach Neoplasms / etiology. Stomach Neoplasms / pathology. Stromal Cells / metabolism

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  • (PMID = 15654792.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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19. Lam-Himlin D, Park JY, Cornish TC, Shi C, Montgomery E: Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol; 2010 Nov;34(11):1656-62
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  • [Title] Morphologic characterization of syndromic gastric polyps.
  • The morphology of gastric hamartomatous polyps from patients with juvenile polyposis syndrome (JuvPS) and Peutz-Jeghers' Syndrome (PJS) is poorly characterized.
  • We investigated the histologic features of gastric polyps in patients with established JuvPS or PJS to develop improved histologic criteria to distinguish these from gastric hyperplastic (HP) polyps.
  • All gastric polyps (n=30) from these patients were intermixed with gastric HP polyps from nonsyndromic patients (n=26) and subsequently blindly reviewed by a panel of gastrointestinal pathologists.
  • A consensus diagnosis was rendered.
  • The panel then reviewed the slides in the context of clinical data and identified histologic features for distinguishing JuvPS, PJS, and HP gastric polyps based on epithelial changes, pit architecture, lamina propria features, and smooth muscle qualities.
  • On initial review, accuracy in diagnosis of gastric polyps in JuvPS was 50% and was 18% in PJS compared with 92% for HP gastric polyps.
  • Adherence to the recommended histologic criteria resulted in diagnostic accuracy of 41% for JuvPS and 54% for PJS, compared with 73% for HP gastric polyps.
  • Accuracy in diagnosis in antral mucosa was 66%, oxyntic mucosa 71%, and transitional-type mucosa (mixed antral and oxyntic) 32%.
  • The diagnostic accuracy based on polyp size was 59% for polyps which were less than equal to 3 mm, 56% for those 4 to 9 mm, and 81% for polyps which were more than equal to 10 mm.
  • The identification of gastric polyps from JuvPS and PJS patients without the context of clinical history of these syndromes remains poor, even with adherence to a set of morphologic criteria.
  • The accuracy did not improve when results were stratified for polyp location but did with biopsy size which were more than equal to10 mm.
  • Whereas these syndromic polyps are readily diagnosed in the small bowel and colon, histologic features to distinguish gastric JuvPS and PJS from gastric HP polyps are unreliable.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Gastric Mucosa / pathology. Hamartoma Syndrome, Multiple / diagnosis. Peutz-Jeghers Syndrome / diagnosis. Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Baltimore. Biopsy. Diagnosis, Differential. Humans. Hyperplasia. Observer Variation. Reproducibility of Results

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  • (PMID = 20924281.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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20. Zurac S, Micu G, Bastian A, Grămadă E, Lavric L, Andrei R, Stăniceanu F, Voiosu R, Croitoru A: Malignancy and overdiagnosis of malignancy in Peutz Jeghers polyposis. Rom J Intern Med; 2008;46(2):179-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two of these cases were related (mother and daughter); both of them were operated in another hospital for small bowel tumors with a subsequent diagnosis of adenocarcinoma.
  • The daughter (28 years old) was referred to our hospital for endoscopic follow-up; a small polyp of the transverse large bowel was excised by colonoscopy with a histopathologic diagnosis of PJ polyp; a careful histopathologic reevaluation of both specimens of enterectomy (slides and paraffin blocks) revealed an overdiagnosis of cancer due to the epithelial cystic dilatation and pseudoinvasion in both patients.
  • The other case showed diagnostic changes of PJS and also various aspects of adenomatous polyps some of them with mild and moderate dysplastic changes.
  • When a PJ polyp is diagnosed, the possibility of pseudoinvasion should be kept in mind, in order to avoid overdiagnosis of malignancy; also, due to the fact that the malignant transformation of a PJ polyp is still on debate (hamartoma-dysplasia-carcinoma sequence versus malignant transformation of an adenomatous aria of a hamartoma versus coincidental association of a digestive cancer due to genetic aberrations of PJS), all the other associated microscopic aspects of the lesion should be carefully analyzed.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Intestinal Neoplasms / pathology. Intestinal Polyps / pathology. Peutz-Jeghers Syndrome / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 19284092.001).
  • [ISSN] 1220-4749
  • [Journal-full-title] Romanian journal of internal medicine = Revue roumaine de médecine interne
  • [ISO-abbreviation] Rom J Intern Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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21. Yuan B, Jin X, Zhu R, Zhang X, Liu J, Wan H, Lu H, Shen Y, Wang F: Cronkhite-Canada syndrome associated with rib fractures: a case report. BMC Gastroenterol; 2010;10:121
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  • Histological examination of the biopsy specimens obtained from the stomach and the colon showed adenomatous polyp and inflammatory polyp respectively.
  • Thus, a diagnosis of CCS was made.
  • [MeSH-major] Intestinal Polyposis / complications. Osteoporotic Fractures / etiology. Rib Fractures / etiology

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  • (PMID = 20955587.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2972238
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22. Joo MK, Park JJ, Lee WW, Lee BJ, Hwang JK, Kim SH, Jung W, Kim JH, Yeon JE, Kim JS, Byun KS, Bak YT: Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals. Endoscopy; 2010 Feb;42(2):114-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals.
  • BACKGROUND AND AIMS: We compared the prevalence of adenomatous and cancerous colon polyps in patients who underwent endoscopic removal of gastric neoplasms and in healthy controls.
  • MATERIALS AND METHODS: This retrospective study reviewed the medical records of 186 patients with gastric neoplasms and 186 healthy subjects from January 2002 to October 2008.
  • The gastric neoplasm group was comprised of patients undergoing endoscopic removal of gastric adenomas or early gastric cancers and serial fiberoptic colonoscopy (FCS) for checkups.
  • The control group was comprised of subjects undergoing fiberoptic esophagogastroduodenoscopy (FEGD) and FCS for general checkup and was matched for age and sex with the gastric neoplasm group.
  • (2) polyp size at least 1.0 cm;.
  • The overall prevalence of adenomatous or cancerous polyps ("all polyps") and the prevalence of advanced colonic neoplasms were significantly higher in the gastric neoplasm group than in the control group (all polyps: 40.9 % in the gastric neoplasm group vs. 25.8 % in the control group, P = 0.002; advanced colonic neoplasms: 15.6 % vs. 8.1 %, P = 0.025).
  • The risk factors for all polyps were age, male sex, diabetes mellitus, and being assigned to the gastric neoplasm group, and those for advanced colonic neoplasms were age and being assigned to the gastric neoplasm group.
  • Confining the analysis to the gastric neoplasm group, the risk factors for all polyps were identical with those for the total group; however, those for advanced colonic neoplasm were different (age vs. diabetes and hypertriglyceridemia).
  • CONCLUSION: Endoscopists should consider performing routine FCS in patients undergoing endoscopic removal of gastric neoplasms.
  • [MeSH-major] Adenoma / surgery. Colonic Polyps / epidemiology. Gastrectomy / methods. Gastroscopy / methods. Stomach Neoplasms / surgery

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20140828.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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23. Wong DC, Wong SK, Leung AL, Chung CC, Li MK: Combined endolaparoscopic intragastric excision for gastric neoplasms. J Laparoendosc Adv Surg Tech A; 2009 Dec;19(6):765-70
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  • [Title] Combined endolaparoscopic intragastric excision for gastric neoplasms.
  • BACKGROUND: The aim of this study was to describe our technique of combined endolaparoscopic approach to the management of intraluminal gastric neoplasms and to review the clinical outcome.
  • METHODS: Between February 2006 and January 2008, a total of 12 patients with gastric neoplasm < or =4 cm with a mainly intraluminal component received the combined endolaparoscopic intragastric excision and were prospectively analyzed.
  • The remaining lesions were adenomatous polyp with focal intramucosal adenocarcinoma, leiomyoma, and pancreatic heterotopia.
  • CONCLUSIONS: This combined endolaparoscopic intragastric excision technique is a truly minimally invasive alternative for selected gastric neoplasm.
  • [MeSH-major] Gastrectomy / methods. Gastrointestinal Stromal Tumors / surgery. Gastroscopy / methods. Laparoscopy / methods. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 19645605.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C: Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers. Gastroenterology; 2010 Dec;139(6):1927-33
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • There were one to innumerable polyps in the colorectum, ileum, duodenum, stomach, and/or esophagus, with 24 subjects having both upper and lower GI polyps.
  • CONCLUSIONS: PTEN-associated CS should be considered a mixed polyp syndrome, with hyperplastic polyps most prevalent, with a risk of early onset colorectal cancer.
  • Routine colonoscopy should be considered in PTEN-associated CS, especially in the context of hyperplastic and/or adenomatous polyps.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20600018.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA124570; United States / NCI NIH HHS / CA / P01CA124570
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS466893; NLM/ PMC3652614
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25. Bartosova Z, Zavodna K, Krivulcik T, Usak J, Mlkva I, Kruzliak T, Hromec J, Usakova V, Kopecka I, Veres P, Bartosova Z, Bujalkova M: STK11/LKB1 germline mutations in the first Peutz-Jeghers syndrome patients identified in Slovakia. Neoplasma; 2007;54(2):101-7
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  • Older patients have an increased risk of the cancers of small intestine, stomach, pancreas, colon, esophagus, ovary, testis, uterus, breast and lung.
  • Neither the polyp nor the tumor of the patient displayed the loss of heterozygosity at the site of mutation suggesting different mechanism involved in the formation of polyp and tumor in this case.
  • Interestingly, the patient displayed concomitant occurrence of adenomatous and hamartomatous polyps.
  • [MeSH-minor] Adult. DNA Mutational Analysis. Female. Genotype. Humans. Intestinal Polyps / pathology. Intestine, Small / pathology. Male. Pedigree. Phenotype. Slovakia

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  • (PMID = 17319781.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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26. Tescher P, Macrae FA, Speer T, Stella D, Gibson R, Tye-Din JA, Srivatsa G, Jones IT, Marion K: Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps. Hered Cancer Clin Pract; 2010;8(1):3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Familial adenomatous polyposis (FAP) is a hereditary disorder characterized by polyposis along the gastrointestinal tract.
  • RESULTS: Within the stomach, upper gastrointestinal endoscopy found more polyps than other forms of imaging.
  • CE was the only form of imaging that identified polyps in all segments of the small bowel as well as the only form of imaging able to provide multiple findings outside the stomach/duodenum.
  • CONCLUSION: CE provides important information on possible polyp development distal to the duodenum, which may lead to surgical intervention.

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  • (PMID = 20361877.001).
  • [ISSN] 1897-4287
  • [Journal-full-title] Hereditary cancer in clinical practice
  • [ISO-abbreviation] Hered Cancer Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC2859487
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