[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 1055
1. Arber N, Eagle CJ, Spicak J, Rácz I, Dite P, Hajer J, Zavoral M, Lechuga MJ, Gerletti P, Tang J, Rosenstein RB, Macdonald K, Bhadra P, Fowler R, Wittes J, Zauber AG, Solomon SD, Levin B, PreSAP Trial Investigators: Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med; 2006 Aug 31;355(9):885-95
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Celecoxib for the prevention of colorectal adenomatous polyps.
  • BACKGROUND: Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention.
  • METHODS: The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, placebo-controlled, double-blind study of the COX-2 inhibitor celecoxib given daily in a single 400-mg dose.
  • Of the 557 subjects in the placebo group and the 840 subjects in the celecoxib group who were included in the efficacy analysis, 264 and 270, respectively, were found to have at least one adenoma at year 1, at year 3, or both.
  • [MeSH-major] Adenoma / prevention & control. Adenomatous Polyps / drug therapy. Colorectal Neoplasms / prevention & control. Cyclooxygenase 2 Inhibitors / therapeutic use. Pyrazoles / therapeutic use. Sulfonamides / therapeutic use

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • Hazardous Substances Data Bank. CELECOXIB .
  • Hazardous Substances Data Bank. ACETYLSALICYLIC ACID .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2006 Massachusetts Medical Society.
  • [CommentIn] N Engl J Med. 2006 Nov 30;355(22):2371; author reply 2371-3 [17135594.001]
  • [CommentIn] N Engl J Med. 2006 Aug 31;355(9):950-2 [16943408.001]
  • (PMID = 16943401.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00141193
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib; R16CO5Y76E / Aspirin
  •  go-up   go-down


2. Mizuno S, Morita Y, Inui T, Asakawa A, Ueno N, Ando T, Kato H, Uchida M, Yoshikawa T, Inui A: Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy. Int J Cancer; 2005 Dec 20;117(6):1058-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy.
  • A significant increase in the incidence of adenomatous polyps (p < 0.0001) and decrease in normal colonoscopic findings (p < 0.0005) were observed in seropositive patients than those seronegative.
  • [MeSH-major] Adenomatous Polyps / microbiology. Colonic Neoplasms / microbiology. Colonic Polyps / microbiology. Colonoscopy. Helicobacter Infections. Helicobacter pylori

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • MedlinePlus Health Information. consumer health - Helicobacter Pylori Infections.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • [CommentIn] Int J Cancer. 2006 Oct 15;119(8):1999-2000 [16708392.001]
  • (PMID = 15986436.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Immunoglobulin G
  •  go-up   go-down


3. Cardoso J, Molenaar L, de Menezes RX, van Leerdam M, Rosenberg C, Möslein G, Sampson J, Morreau H, Boer JM, Fodde R: Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cancer Res; 2006 Mar 01;66(5):2514-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosomal instability in MYH- and APC-mutant adenomatous polyps.
  • Recently, biallelic germ line mutations in the MYH gene were found to be responsible for MYH-associated polyposis (MAP), an autosomal recessive predisposition to multiple colorectal polyps, often indistinguishable from the dominant familial adenomatous polyposis (FAP) syndrome caused by inherited APC mutations.
  • Here, we analyzed MYH- and APC-mutant polyps by combining laser capture microdissection, isothermal genomic DNA amplification, and array comparative genomic hybridization.
  • Up to 80% and 60% of the MAP and FAP polyps showed aneuploid changes, respectively.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Aneuploidy. Chromosomal Instability. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Genes, APC. Germ-Line Mutation

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16510566.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0301154
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  •  go-up   go-down


Advertisement
4. Tsai IC, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM: Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer; 2007 Mar 1;120(5):1005-12
Xenbase. Xenbase .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
  • We speculated that mutations in the autoinhibitory domain of CKIdelta/epsilon might upregulate CKIdelta/epsilon activity and hence Wnt signaling and increase the risk of adenomatous polyps and colon cancer.
  • Exons encoding the CKIepsilon and CKIdelta regulatory domains were sequenced from DNA obtained from individuals with adenomatous polyps and a family history of colon cancer unaffected by familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer (HNPCC).
  • A CKIdelta missense mutation, changing a highly conserved residue, Arg324, to His (R324H), was found in an individual with large and multiple polyps diagnosed at a relatively young age.
  • Although the R324H mutation does not significantly change CKIdelta kinase activity in an in vitro kinase assay or Wnt/beta-catenin signal transduction as assessed by a beta-catenin reporter assay, it alters morphogenetic movements via a beta-catenin-independent mechanism in early Xenopus development.
  • This novel human CKIdelta mutation may alter the physiological role and enhance the transforming ability of CKIdelta through a Wnt/beta-catenin independent mechanism and thereby influence colonic adenoma development.
  • [MeSH-major] Adenomatous Polyps / genetics. Casein Kinase Idelta / genetics. Colonic Neoplasms / genetics

  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. (L)-HISTIDINE .
  • Hazardous Substances Data Bank. (L)-ARGININE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 17131344.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / PC / N01-PC-3541; United States / NCI NIH HHS / CA / P01 CA73992; United States / NCI NIH HHS / CA / P30 CA42014; United States / NCI NIH HHS / CA / R01 CA40641; United States / NCI NIH HHS / CA / R01 CA80809
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin; 4QD397987E / Histidine; 94ZLA3W45F / Arginine; EC 2.7.11.1 / Casein Kinase Idelta
  •  go-up   go-down


5. Yeruham I, Perl S, Lahav D: Anal adenomatous polyps in a crossbred beef cow. Vet Rec; 2005 Aug 13;157(7):204
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal adenomatous polyps in a crossbred beef cow.
  • [MeSH-major] Adenomatous Polyps / veterinary. Anus Neoplasms / veterinary. Cattle Diseases / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16100372.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


6. Kim H, Kim HJ, Chi SG, Lee SK, Joo GR, Dong SH, Kim BH, Chang YW, Lee JI, Chang R: Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea. World J Gastroenterol; 2006 Feb 14;12(6):951-5
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea.
  • AIM: Recently, germ-line mutation in the base excision repair gene MYH has been identified to cause a novel autosomal recessive form of familial adenomatous polyposis (FAP).
  • In this study, we screened 30 patients with multiple adenomatous polyps for MYH mutations to assess its prevalence and ethnic specificity in Korea.
  • METHODS: Thirty patients (21 men and 9 women; mean age 62.3 years) with multiple adenomatous polyps were examined for MYH mutations.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Mutation

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer Res. 2003 Nov 15;63(22):7595-9 [14633673.001]
  • [Cites] Lancet. 2003 Jul 5;362(9377):5-6 [12853190.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):533-7 [2841598.001]
  • [Cites] Nature. 1991 Jan 31;349(6308):431-4 [1992344.001]
  • [Cites] Ann Hum Genet. 1992 May;56(Pt 2):99-103 [1503398.001]
  • [Cites] J Bacteriol. 1992 Oct;174(20):6321-5 [1328155.001]
  • [Cites] Nature. 1993 Apr 22;362(6422):709-15 [8469282.001]
  • [Cites] Mol Gen Genet. 1993 May;239(1-2):72-6 [8510665.001]
  • [Cites] J Biol Chem. 1993 Nov 5;268(31):23524-30 [8226881.001]
  • [Cites] Mol Cell Biol. 1995 Feb;15(2):989-96 [7823963.001]
  • [Cites] Pathol Biol (Paris). 1996 Jan;44(1):6-13 [8734294.001]
  • [Cites] Mol Gen Genet. 1997 Mar 26;254(2):171-8 [9108279.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8016-20 [9223306.001]
  • [Cites] Oncogene. 1998 Jun 25;16(25):3219-25 [9681819.001]
  • [Cites] Mutat Res. 1998 May 25;400(1-2):99-115 [9685598.001]
  • [Cites] Nucleic Acids Res. 1999 Sep 15;27(18):3638-44 [10471731.001]
  • [Cites] Nucleic Acids Res. 2000 Mar 15;28(6):1355-64 [10684930.001]
  • [Cites] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514.001]
  • [Cites] Hum Mol Genet. 2000 Sep 22;9(15):2215-21 [11001924.001]
  • [Cites] Int J Cancer. 2000 Dec 15;88(6):932-7 [11093817.001]
  • [Cites] Hum Mol Genet. 2001 Apr;10(7):721-33 [11257105.001]
  • [Cites] Cancer Lett. 2001 Sep 10;170(1):53-61 [11448535.001]
  • [Cites] Nat Genet. 2002 Feb;30(2):227-32 [11818965.001]
  • [Cites] Hum Mol Genet. 2002 Nov 1;11(23):2961-7 [12393807.001]
  • [Cites] N Engl J Med. 2003 Feb 27;348(9):791-9 [12606733.001]
  • [Cites] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2709-13 [3128795.001]
  • (PMID = 16521226.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC4066163
  •  go-up   go-down


7. Maisonneuve P, Botteri E, Lowenfels AB: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps. Gastroenterology; 2008 Aug;135(2):710; author reply 710-1
International Agency for Research on Cancer - Screening Group. diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Colorectal Neoplasms / diagnosis. Mass Screening / standards

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] Gastroenterology. 2008 May;134(5):1570-95 [18384785.001]
  • (PMID = 18619444.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  •  go-up   go-down


8. Jung WT, Li MS, Goel A, Boland CR: JC virus T-antigen expression in sporadic adenomatous polyps of the colon. Cancer; 2008 Mar 1;112(5):1028-36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] JC virus T-antigen expression in sporadic adenomatous polyps of the colon.
  • The hypothesis that JCV DNA sequences and T-antigen (T-Ag) expression may be present in adenomatous polyps of the colon was tested.
  • METHODS: DNA was extracted from 74 paraffin-embedded adenomatous polyps.
  • RESULTS: JCV T-Ag sequences were found in 82% (61 of 74) of adenomas, and T-Ag protein was expressed in 16% (12 of 74) of these polyps.
  • The T-Ag staining was localized exclusively in the nuclei of adenoma cells, but never in the cytoplasm or the adjacent nonneoplastic cells.
  • The prevalence of MSI-H and non-MSI-H (MSI-L/MSS) in adenomatous polyps was 9.5% (7 of 74) and 90.5% (67 of 74), respectively.
  • Among the 61 adenomas that harbored JCV sequences, 8% (5 of 61) were MSI-H, and similarly among 12 adenomatous polyps expressing T-Ag protein 8% (1 of 12) of the adenomatous polyps were MSI-H.
  • CONCLUSIONS: JCV T-Ag DNA sequences are frequently present in adenomatous polyps of the colon, and T-Ag is expressed specifically in the nuclei of these premalignant lesions.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] N Engl J Med. 2000 Jan 13;342(2):69-77 [10631274.001]
  • [Cites] Clin Cancer Res. 2005 Dec 1;11(23):8332-40 [16322293.001]
  • [Cites] Mol Cell Biol. 2000 Sep;20(17):6233-43 [10938100.001]
  • [Cites] Virology. 2000 Aug 15;274(1):165-78 [10936097.001]
  • [Cites] Int J Colorectal Dis. 2000 Aug;15(4):189-96 [11008717.001]
  • [Cites] Gastroenterology. 2000 Nov;119(5):1228-35 [11054380.001]
  • [Cites] J Virol. 2001 Feb;75(4):1996-2001 [11160700.001]
  • [Cites] Cancer Res. 2001 May 15;61(10):4287-93 [11358858.001]
  • [Cites] Oncogene. 2001 Aug 9;20(35):4864-70 [11521197.001]
  • [Cites] Am J Pathol. 2001 Dec;159(6):2107-16 [11733361.001]
  • [Cites] Gut. 2002 Mar;50(3):382-6 [11839719.001]
  • [Cites] J Natl Cancer Inst. 2002 Feb 20;94(4):267-73 [11854388.001]
  • [Cites] Gastroenterology. 2002 Dec;123(6):1804-11 [12454837.001]
  • [Cites] Cancer Res. 2002 Dec 1;62(23):7093-101 [12460931.001]
  • [Cites] J Neurovirol. 2002 Dec;8 Suppl 2:138-47 [12491166.001]
  • [Cites] J Gen Virol. 2003 Jun;84(Pt 6):1499-504 [12771419.001]
  • [Cites] Oncogene. 2003 Aug 11;22(33):5181-91 [12910255.001]
  • [Cites] Gastroenterology. 2004 Jan;126(1):42-8 [14699485.001]
  • [Cites] J Natl Cancer Inst. 2004 Feb 18;96(4):261-8 [14970275.001]
  • [Cites] Microbiol Immunol. 1982;26(11):1057-64 [6300615.001]
  • [Cites] J Virol. 1984 Aug;51(2):458-69 [6086957.001]
  • [Cites] J Virol. 1989 Feb;63(2):863-72 [2536108.001]
  • [Cites] J Virol. 1990 Mar;64(3):1353-6 [2154613.001]
  • [Cites] J Virol. 1992 Jul;66(7):3979-85 [1318392.001]
  • [Cites] Science. 1993 May 7;260(5109):812-6 [8484121.001]
  • [Cites] Science. 1993 May 7;260(5109):816-9 [8484122.001]
  • [Cites] Nature. 1993 Jun 10;363(6429):558-61 [8505985.001]
  • [Cites] Cancer Res. 1994 Apr 1;54(7):1645-8 [8137274.001]
  • [Cites] Int J Mol Med. 1998 Apr;1(4):647-55 [9852278.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7484-9 [10377441.001]
  • [Cites] J Gastroenterol Hepatol. 2005 Dec;20(12):1920-6 [16336454.001]
  • [Cites] Gut. 2006 May;55(5):695-702 [16354798.001]
  • [Cites] Gastroenterology. 2006 Jun;130(7):1950-61 [16762618.001]
  • [Cites] Cancer. 2006 Aug 1;107(3):481-8 [16795066.001]
  • [Cites] Gastroenterology. 2007 Jan;132(1):127-38 [17087942.001]
  • [Cites] J Neuropathol Exp Neurol. 2004 Nov;63(11):1124-30 [15581180.001]
  • [Cites] Cancer. 2005 Feb 1;103(3):516-27 [15630684.001]
  • [Cites] Dis Colon Rectum. 2005 Jan;48(1):86-91 [15690663.001]
  • [Cites] Am J Gastroenterol. 2005 May;100(5):1143-9 [15842591.001]
  • [Cites] Anticancer Res. 2005 Mar-Apr;25(2A):1079-85 [15868949.001]
  • [Cites] Gut. 2005 Sep;54(9):1321-31 [16099799.001]
  • [Cites] Virchows Arch. 2005 Oct;447(4):723-30 [16021515.001]
  • [Cites] Gut. 2000 Jul;47(1):37-42 [10861262.001]
  • (PMID = 18205186.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA098572-05; United States / NCI NIH HHS / CA / R01 CA098572; United States / NCI NIH HHS / CA / R01 CA 98572; United States / NCI NIH HHS / CA / R01 CA098572-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
  • [Other-IDs] NLM/ NIHMS187525; NLM/ PMC2855201
  •  go-up   go-down


9. Kim BJ, Kim YH, Sinn DH, Kang KJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC: Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males. Cancer Causes Control; 2010 Jun;21(6):939-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males.
  • RESULTS: Subjects in their 50 s had significantly more adenomatous polyps than subjects in their 40 s (32.7% vs. 26.0%, p < 0.05).
  • The incidence of adenomatous polyp increased with increasing quartiles of HbA1C as follows: first quartile (19.9%, HbA1c 4.0-5.0), second quartile (27.8%, HbA1c 5.1-5.3), third quartile (32.7%, HbA1c 5.4-5.5), and fourth quartile (34.9%, HbA1c = 5.6-8.8)(p = 0.008).
  • When combining quartile of HbA1c and age (40 s vs. 50 s) according to HbA1C levels, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c <5.4% was significantly lower than that in subjects in their 50 s.
  • However, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c > or =5.4% was similar to that in subjects in their 50 s with average risk for CRC.
  • CONCLUSIONS: An elevated HbA1c may be useful as a clinical predictor of adenomatous polyps in male subjects <50 years of age who have average risk for CRC.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20373014.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hemoglobin A, Glycosylated
  •  go-up   go-down


10. Smith GV, Feakins R, Farthing MJ, Ballinger A: Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. Am J Clin Pathol; 2005 Mar;123(3):415-20
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps.
  • Gastric adenomatous polyps are rare findings in upper gastrointestinal endoscopy; however, they are associated strongly with malignant transformation.
  • In the present study, we immunohisto-chemically assessed the expression of cyclooxygenase (COX)-2, beta-catenin, p53, and adenomatous polyposis coli (APC) in paraffin-embedded specimens of 14 gastric adenomas.
  • Similar alterations in oncoprotein expression were seen in gastric cancers but not in normal control sections.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Adenomatous Polyps / metabolism. Cytoskeletal Proteins / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism. Stomach Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Protein p53 / metabolism

  • MedlinePlus Health Information. consumer health - Stomach Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15716238.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
  •  go-up   go-down


11. Robb-Nicholson C: By the way, doctor. I keep hearing that aspirin can help prevent colon cancer, but I have no idea how much I should take. Can you help? I've had adenomatous polyps in the past. Harv Womens Health Watch; 2010 Dec;18(4):8
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] By the way, doctor. I keep hearing that aspirin can help prevent colon cancer, but I have no idea how much I should take. Can you help? I've had adenomatous polyps in the past.
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Aspirin / administration & dosage. Colonic Neoplasms / prevention & control. Health Knowledge, Attitudes, Practice

  • Hazardous Substances Data Bank. ACETYLSALICYLIC ACID .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21268798.001).
  • [ISSN] 1070-910X
  • [Journal-full-title] Harvard women's health watch
  • [ISO-abbreviation] Harv Womens Health Watch
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; R16CO5Y76E / Aspirin
  •  go-up   go-down


12. Sato Y, Nozaki R, Yamada K, Takano M, Haruma K: Relation between obesity and adenomatous polyps of the large bowel. Dig Endosc; 2009 Jul;21(3):154-7
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relation between obesity and adenomatous polyps of the large bowel.
  • BACKGROUND: We compared the prevalence of colorectal adenoma (polyps) in men and women and examined the role of body mass index (BMI) on polyp risk according to patient age and gender.
  • METHODS: The risk of developing colorectal polyps was studied in 15 380 subjects (7155 men and 8225 women) who underwent colonoscopy for the first time from April 1998 to March 2006 at our 'Human Dry Dock', which is the check-up service provided in Japan.
  • Eligible subjects were 20-86 years old (mean age +/- SD, 47.3 +/- 8.5) and were free of invasive cancer, hyperplastic polyps and familial polyposis.
  • Polyps were found in 1590 subjects (1062 men and 528 women).
  • The odds ratio (OR) of detection of polyps in relation to obesity was determined in all cases by multivariate logistic regression analysis after making an adjustment for gender and age.
  • RESULTS: The OR of polyp detection in obese subjects (BMI >or= 25) versus non-obese subjects (BMI < 25, OR = 1) was 1.34 (P < 0.001) in men and 1.13 (P = 0.26) in women.
  • CONCLUSIONS: We conclude that obesity in men is a risk factor for the development of polyps.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology

  • Genetic Alliance. consumer health - Obesity.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19691761.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  •  go-up   go-down


13. McLean MH, Murray GI, Fyfe N, Hold GL, Mowat NA, El-Omar EM: COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. Histopathology; 2008 Jun;52(7):806-15
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics.
  • AIMS: To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation.
  • The number of adenoma specimens was then extended to include polyps exhibiting an increasing degree of epithelial dysplasia.
  • Forty colonic hyperplastic polyps were also identified from the pathology diagnostic database and included in the analysis.
  • There was a statistically significant increase in COX-2 expression in colonic polyps compared with paired adjacent normal mucosa, chi(2) = 40.1, P = 0.001.
  • The probability of COX-2 expression increased along with increasing adenoma size and increasing degree of epithelial dysplasia.
  • Fifty-five per cent of the hyperplastic polyp specimens expressed COX-2.
  • CONCLUSIONS: This study associates COX-2 epithelial expression with a number of adenoma characteristics that convey an increased risk of malignant transformation.
  • [MeSH-major] Adenomatous Polyps / enzymology. Colonic Polyps / enzymology. Colorectal Neoplasms / enzymology. Cyclooxygenase 2 / metabolism. Intestinal Mucosa / enzymology

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18462368.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  •  go-up   go-down


14. Ramadas A Jr, Kandiah M, Zarida H, Yunus Gul AG, Faizal JA: Obesity and risk of colorectal adenomatous polyps: a case-control study in hospital kuala lumpur. Malays J Nutr; 2009 Mar;15(1):1-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obesity and risk of colorectal adenomatous polyps: a case-control study in hospital kuala lumpur.
  • Several studies have proposed that obesity is a risk factor for colorectal adenoma.
  • This case-control study examined the relationship between body mass index (BMI), waist circumference, waistto-hip ratio (WHR), body fat percentage and colorectal adenomatous polyps (CRA) in patients who have had a colonoscopy at the Hospital Kuala Lumpur (HKL).
  • The mean BMI of female case subjects was significantly higher than control females (25.63 + 4.87 kg/m2 vs. 23.86 + 3.70 kg/m2, p<0.05) but the difference in BMI was not significant in men.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 22691799.001).
  • [ISSN] 1394-035X
  • [Journal-full-title] Malaysian journal of nutrition
  • [ISO-abbreviation] Malays J Nutr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  •  go-up   go-down


15. Stelzner F: [Autoregulatory growth control of adenomatous polyps and carcinogenesis in the colorectal region. Basics of tumor surgery Part I]. Chirurg; 2006 Nov;77(11):1048-55
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Autoregulatory growth control of adenomatous polyps and carcinogenesis in the colorectal region. Basics of tumor surgery Part I].
  • Autoregulatory growth control of adenomatous polyps in the colon and rectum is an important factor in the success of sphincter-sparing surgical resections.
  • Similar to normal mucosa, adenomatous polyps in the colorectum show autoregulatory growth control in their tissues.
  • However, convincing evidence on a molecular level that this so-called adenoma-carcinoma sequence indeed occurs in vivo is lacking.
  • [MeSH-major] Adenomatous Polyps / pathology. Cell Division / physiology. Colonic Polyps / pathology. Colonic Polyps / surgery. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Homeostasis / physiology
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Bone Marrow Cells / pathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Chromosome Aberrations. Colon / pathology. Colon / surgery. Gene Expression Regulation, Neoplastic / physiology. Humans. Neoplasm Staging. Prognosis. Rectum / pathology. Rectum / surgery

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Chirurg. 2006 Nov;77(11):1061-2 [17066270.001]
  • (PMID = 17068665.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


16. Guo X, Zhang L, Wu M, Wang N, Liu Y, Er L, Wang S, Gao Y, Yu W, Xue H, Xu Z, Wang S: Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma. Mol Biol Rep; 2010 Jan;37(1):219-25
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.
  • The aim of this study is to investigate the correlation of the DNMT3B G39179T polymorphism with the susceptibilities of colorectal adenomatous polyps and adenocarcinoma.
  • This case-control study included 146 colorectal adenomatous polyps, 170 colorectal adenocarcinoma patients, and 157 normal controls.
  • Family history of colorectal cancer significantly increases the risk of developing colorectal adenomatous polyps and adenocarcinoma.
  • Compared with DNMT3B T/T genotype, the G allelotype (G/T + G/G genotype) had lower risk to develop colorectal adenocarcinoma (OR = 0.50, 95% CI = 0.29-0.87); while there was no significant difference between the colorectal adenomatous polyps patients and controls (OR = 0.63, 95% CI = 0.37-1.09), although descending tendency could be found in this polyps group.
  • Meanwhile, combined G/T + G/G genotypes were found to have a lower risk in non-drinkers to develop both colorectal adenomatous polyps and adenocarcinoma (OR = 0.54, 95% CI = 0.31-0.96 and OR = 0.48, 95% CI = 0.27-0.84, respectively).
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyps / genetics. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / genetics. DNA (Cytosine-5-)-Methyltransferase / genetics. Genetic Predisposition to Disease. Polymorphism, Single Nucleotide / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19626461.001).
  • [ISSN] 1573-4978
  • [Journal-full-title] Molecular biology reports
  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA methyltransferase 3B
  •  go-up   go-down


17. Park SY, Kim BC, Shin SJ, Lee SK, Kim TI, Kim WH: Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years. Hepatogastroenterology; 2009 May-Jun;56(91-92):677-81
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years.
  • BACKGROUND/AIMS: Several reports have suggested a trend of right-side shift of colorectal cancer; however, there were only a few studies on the chronologic changes in the distribution of adenomatous polyps.
  • We aimed to study the changes in the distribution of colorectal adenomatous polyps over the past ten years.
  • Patients who had an adenomatous polyp with a diameter of at least 5mm were included.
  • Of these, patients with a history of colon resection, colorectal cancer, colorectal polyp, inflammatory bowel disease, HNPCC, or familial adenomatous polyposis were excluded.
  • RESULTS: A total of 2,498 patients and 4,591 adenomatous polyps were included in this study.
  • Analysis with respect to number of patients showed significant increases in the proportion of patients with adenomatous polyp on the proximal colon, from 48.5% to 66.3% (p<0.001).
  • Analysis with respect to number of polyps revealed that the proportion of adenomatous polyps on the proximal colon significantly increased from 48.9% to 62.3% (p<0.001).
  • CONCLUSIONS: The proportion of adenomatous polyp on the proximal colon significantly increased over the past 10 years.
  • [MeSH-major] Adenomatous Polyposis Coli / ethnology. Adenomatous Polyposis Coli / pathology. Asian Continental Ancestry Group / statistics & numerical data

  • Genetic Alliance. consumer health - TEN.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19621679.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


18. Cappell MS: The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps. Med Clin North Am; 2005 Jan;89(1):1-42, vii
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps.
  • A review of the pathophysiology, clinical presentation, and diagnosis of colon cancer and colonic polyps is important and timely.
  • This article reviews colon cancer and colonic polyps, with a focus on recent dramatic advances, to help the pri-mary care physician and internist appropriately refer patients for screening colonoscopy and intelligently evaluate colonoscopic findings to reduce the mortality from this cancer.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / physiopathology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / physiopathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15527807.001).
  • [ISSN] 0025-7125
  • [Journal-full-title] The Medical clinics of North America
  • [ISO-abbreviation] Med. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 251
  •  go-up   go-down


19. Su YH, Wang M, Brenner DE, Norton PA, Block TM: Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. Ann N Y Acad Sci; 2008 Aug;1137:197-206
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Clin Cancer Res. 2001 Sep;7(9):2727-30 [11555585.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:40-3 [15251937.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:81-9 [15251944.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:271-81 [15251972.001]
  • [Cites] Oncol Res. 2004;14(9):439-45 [15490975.001]
  • [Cites] J Clin Invest. 1973 Jan;52(1):198-204 [4629907.001]
  • [Cites] Cancer Res. 1977 Mar;37(3):646-50 [837366.001]
  • [Cites] Arthritis Rheum. 1982 Dec;25(12):1425-30 [6128984.001]
  • [Cites] Cancer. 1983 Jun 1;51(11):2116-20 [6188527.001]
  • [Cites] J Virol Methods. 1984 Feb;8(1-2):73-86 [6323510.001]
  • [Cites] J Clin Invest. 1984 Mar;73(3):832-41 [6323528.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Pathol Int. 1995 Oct;45(10):721-8 [8563932.001]
  • [Cites] Toxicol Lett. 1995 Dec;82-83:143-8 [8597042.001]
  • [Cites] Nat Med. 1996 Sep;2(9):1033-5 [8782463.001]
  • [Cites] Nat Med. 1996 Sep;2(9):1035-7 [8782464.001]
  • [Cites] Cancer Res. 2001 Feb 15;61(4):1659-65 [11245480.001]
  • [Cites] Clin Chem. 2006 Oct;52(10):1833-42 [16423903.001]
  • [Cites] Gut. 1999 Nov;45(5):686-92 [10517904.001]
  • [Cites] Cancer Metastasis Rev. 1999;18(1):65-73 [10505546.001]
  • [Cites] Mod Pathol. 1999 Jun;12(6):604-11 [10392637.001]
  • [Cites] Cancer Res. 1999 Jan 1;59(1):71-3 [9892188.001]
  • [Cites] Cancer Res. 1999 Jan 1;59(1):67-70 [9892187.001]
  • [Cites] Cancer Res. 1998 Oct 15;58(20):4728-32 [9788629.001]
  • [Cites] Lancet. 1997 Aug 16;350(9076):485-7 [9274585.001]
  • [Cites] Gastroenterology. 2000 Nov;119(5):1219-27 [11054379.001]
  • [Cites] Cancer Genet Cytogenet. 2000 Aug;121(1):73-7 [10958945.001]
  • [Cites] Clin Chem. 2000 Aug;46(8 Pt 1):1078-84 [10926886.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:1-8 [15251932.001]
  • [Cites] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3972-9 [15217927.001]
  • [Cites] J Mol Diagn. 2004 May;6(2):101-7 [15096565.001]
  • [Cites] Clin Cancer Res. 2004 Mar 15;10(6):1887-93 [15041703.001]
  • [Cites] Clin Chem. 2004 Jan;50(1):211-3 [14709652.001]
  • [Cites] Cancer Res. 2003 Sep 15;63(18):5723-6 [14522891.001]
  • [Cites] Cancer Res. 2003 May 1;63(9):2028-32 [12727814.001]
  • [Cites] Ann Clin Biochem. 2003 Mar;40(Pt 2):122-30 [12662399.001]
  • [Cites] Clin Cancer Res. 2002 Oct;8(10):3156-63 [12374683.001]
  • [Cites] Clin Cancer Res. 2002 Jan;8(1):35-40 [11801538.001]
  • [Cites] Gut. 1997 May;40(5):660-3 [9203947.001]
  • [Cites] Gastroenterology. 2001 Sep;121(3):599-611 [11522744.001]
  • [Cites] Gastroenterology. 2001 Aug;121(2):302-9 [11487539.001]
  • [Cites] Bull Exp Biol Med. 2001 Mar;131(3):283-4 [11427923.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:17-24 [15251934.001]
  • (PMID = 18837947.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA125642-01A2; United States / NCI NIH HHS / CA / CA86400; United States / NCI NIH HHS / CA / R01 CA125642; United States / NCI NIH HHS / CA / U01 CA086400; United States / NCI NIH HHS / CA / CA125642-01A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 9007-49-2 / DNA; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ NIHMS72455; NLM/ PMC2587049
  •  go-up   go-down


20. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev; 2008;(1):CD003548
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps.
  • Experimental and epidemiological evidence has been suggestive but not conclusive for a protective role for high dietary calcium intake.
  • Intervention studies with colorectal cancer as an endpoint are difficult to perform owing to the large number of patients and the long follow-up required; studies using the appearance of colorectal adenomatous polyps as a surrogate endpoint are therefore considered in reviewing the existing evidence.
  • OBJECTIVES: This systematic review aims to assess the effect of supplementary dietary calcium on the incidence of colorectal cancer and the incidence or recurrence of adenomatous polyps.
  • SELECTION CRITERIA: Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in humans are reviewed.
  • Studies of healthy adults and studies of adults at higher risk of colon cancer due to family history, previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are excluded.
  • For the development of recurrent colorectal adenoma, a reduction was found (OR 0.74, CI 0.58,0.95) when the results from both trials were combined.
  • AUTHORS' CONCLUSIONS: Although the evidence from two RCTs suggests that calcium supplementation might contribute to a moderate degree to the prevention of colorectal adenomatous polyps, this does not constitute sufficient evidence to recommend the general use of calcium supplements to prevent colorectal cancer.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Calcium, Dietary / therapeutic use. Colorectal Neoplasms / prevention & control. Dietary Supplements
  • [MeSH-minor] Adenoma / complications. Humans. Randomized Controlled Trials as Topic


21. Benes Z, Antos Z: Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy. Anticancer Res; 2009 Nov;29(11):4737-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy.
  • BACKGROUND: It has been established that the removal of adenomatous colon polyps drastically reduces the incidence of colorectal cancer (CRC), but polypectomy is not without risk.
  • The aim was to determine the correlation between the results of an optical biopsy system and the histopathology report of the physical biopsy specimens of the same polyps removed at colonoscopy.
  • PATIENTS AND METHODS: Paired optical and physical biopsies were performed on 55 polyps with complete polypectomy of the same tissue.
  • RESULTS: Fifty-three adenomatous polyps and two hyperplastic polyps were identified by the hospital pathologist.
  • The optical biopsy system identified 52 polyps as suspect (adenomatous) and 2 as non-suspect (hyperplastic).
  • One villous adenoma could not be optically analyzed due to friability.
  • CONCLUSION: The WavSTAT Optical Biopsy System provides accurate information to the gastroenterologist to assist in distinguishing between hyperplastic and adenomatous polyps.
  • It is safe for the patient and does not unduly increase the time required for an endoscopic examination.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colon / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy / methods. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonoscopy / methods. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Middle Aged. Optics and Photonics / methods. Prospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20032428.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


22. Ghelase F, Mogoş DS, Mărgăritescu D, Iordache S, Ghelase MS, Râmboiu S, Mogoş G, Bică M, Săftoiu A, Georgescu I: [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications]. Chirurgia (Bucur); 2009 Mar-Apr;104(2):159-65
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications].
  • AIM: To detect the patients with colorectal adenomatous polyps or those with adenocarcinoma areas with a view to prevent and to treat the malignant disease.
  • MATERIAL AND METHOD: A prospective study including 309 patients hospitalized between 2000-2005 diagnosed with isolated adenomatous polyps after repeated colonoscopies.
  • The research method was selective screening with identification of risk factors regarding the evolution of colorectal polyps in early cancer, using colonoscopy and histopathological examination.
  • RESULTS: We identified 464 single or multiple isolated polyps of which 399 were adenomas, 59 hyperplastic polyps and 6 other types of lesions.
  • Histologically we recorded 41 (13.27%) polyps with a low grade of dysplasia, 56 (18.12%) with severe dysplasia and 30 (9.7%) intramucosal adenocarcinoma with submucosal invasion.
  • TREATMENT: Colonoscopic polypectomy was used for benign polyps and in situ carcinoma.
  • CONCLUSIONS: High grade of dysplasia, the number of polyps, ulceration, bleeding, intraepithelial areas of neoplastic transformation are predictive factors for early colorectal cancer.
  • Depth of submucosal invasion of malignant transformed polyps are important pathological factors to predict lymphatic metastasis and to select the therapeutic procedure.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Colectomy / methods. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Cell Transformation, Neoplastic / pathology. Colonic Polyps / diagnosis. Colonic Polyps / surgery. Female. Humans. Male. Prospective Studies. Risk Factors. Treatment Outcome

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19499658.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


23. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev; 2005;(3):CD003548
SciCrunch. DrugBank: Data: Chemical .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps.
  • Experimental and epidemiological evidence has been suggestive but not conclusive for a protective role for high dietary calcium intake.
  • Intervention studies with colorectal cancer as an endpoint are difficult to perform owing to the large number of patients and the long follow-up required; studies using the appearance of colorectal adenomatous polyps as a surrogate endpoint are therefore considered in reviewing the existing evidence.
  • OBJECTIVES: This systematic review aims to assess the effect of supplementary dietary calcium on the incidence of colorectal cancer and the incidence or recurrence of adenomatous polyps.
  • SELECTION CRITERIA: Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in humans are reviewed.
  • Studies of healthy adults and studies of adults at higher risk of colon cancer due to family history, previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are excluded.
  • For the development of recurrent colorectal adenoma, a reduction was found (OR 0.74, CI 0.58,0.95) when the results from both trials were combined.
  • AUTHORS' CONCLUSIONS: Although the evidence from two RCTs suggests that calcium supplementation might contribute to a moderate degree to the prevention of colorectal adenomatous polyps, this does not constitute sufficient evidence to recommend the general use of calcium supplements to prevent colorectal cancer.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Calcium, Dietary / therapeutic use. Colorectal Neoplasms / prevention & control. Dietary Supplements
  • [MeSH-minor] Adenoma / complications. Humans. Randomized Controlled Trials as Topic


24. Kim JH, Lee SY, Kim BK, Choe WH, Kwon SY, Sung IK, Park HS, Jin CJ: Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy. World J Gastroenterol; 2008 Mar 28;14(12):1903-7
Hazardous Substances Data Bank. ACETIC ACID .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy.
  • AIM: To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy.
  • METHODS: Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision.
  • Both pre- and post-sprayed images were shown to 16 examiners, who were asked to interpret the lesions as either hyperplastic or adenomatous polyps.
  • Regression analysis demonstrated that surrounding colonic mucosa was the only factor that was significantly related to accuracy in discriminating adenomatous from hyperplastic polyps (P < 0.001).
  • Accuracy was higher for polyps with linear surrounding colonic mucosa than for those with nodular surrounding colonic mucosa (P < 0.001), but was not related to the shape, location, or size of the polyp.
  • CONCLUSION: The accuracy of predicting histology is significantly related to the pattern of colonic mucosa surrounding the polyp.
  • Making a histological diagnosis of colon polyps merely by acetic acid spray is helpful for colon polyps with linear, regularly patterned surrounding colonic mucosa, and less so for those with nodular, irregularly patterned surrounding colonic mucosa.
  • [MeSH-major] Acetic Acid. Adenomatous Polyps. Colonic Polyps. Endoscopy / methods. Hyperplasia. Intestinal Mucosa

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Endoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Gastrointest Endosc. 2003 Jan;57(1):48-53 [12518130.001]
  • [Cites] Endoscopy. 2003 May;35(5):437-45 [12701018.001]
  • [Cites] Ann Surg. 1987 Jun;205(6):659-64 [3592808.001]
  • [Cites] Gastroenterology. 1996 Apr;110(4):1253-8 [8613016.001]
  • [Cites] Gastrointest Endosc. 1996 Jul;44(1):8-14 [8836710.001]
  • [Cites] Endoscopy. 2004 Dec;36(12):1089-93 [15578300.001]
  • [Cites] Gastrointest Endosc. 2002 May;55(6):687-94 [11979251.001]
  • [Cites] Gastrointest Endosc. 2006 May;63(6):824-8 [16650546.001]
  • [Cites] World J Gastroenterol. 2006 Apr 21;12(15):2402-5 [16688833.001]
  • [Cites] Gastrointest Endosc. 2006 Jun;63(7):1010-7 [16733118.001]
  • [Cites] CA Cancer J Clin. 2006 May-Jun;56(3):143-59; quiz 184-5 [16737947.001]
  • [Cites] Endoscopy. 2006 Jun;38(6):613-6 [16612744.001]
  • [Cites] Gastrointest Endosc. 2006 Jul;64(1):13-6 [16813796.001]
  • [Cites] World J Gastroenterol. 2006 Mar 7;12(9):1416-20 [16552812.001]
  • (PMID = 18350630.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] Q40Q9N063P / Acetic Acid
  • [Other-IDs] NLM/ PMC2700415
  •  go-up   go-down


25. Ji BT, Weissfeld JL, Chow WH, Huang WY, Schoen RE, Hayes RB: Tobacco smoking and colorectal hyperplastic and adenomatous polyps. Cancer Epidemiol Biomarkers Prev; 2006 May;15(5):897-901
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tobacco smoking and colorectal hyperplastic and adenomatous polyps.
  • Colorectal adenomas and possibly some hyperplastic polyps are precursors of colorectal cancer.
  • Tobacco use is associated in epidemiologic studies with these polyps, although links between smoking and colorectal cancer are less consistent.
  • To characterize the role of tobacco in early colorectal carcinogenesis, we compared tobacco use among 4,383 subjects with histologically verified benign (hyperplastic or adenomatous) polyps of the distal colon (descending colon, sigmoid, and rectum) with tobacco use among 33,667 subjects who were endoscopy negative for distal colon tumors, in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Trial, a randomized trial of flexible sigmoidoscopy.
  • Risks, estimated by the odds ratio (OR), associated with current cigarette use were OR = 4.4 [95% confidence interval (95% CI), 3.7-5.2] for hyperplastic polyps only, OR = 1.8 (95% CI, 1.5-2.1) for adenomas only, and OR = 6.2 (95% CI, 4.7-8.3) for subjects with both hyperplastic and adenomatous polyps concurrently.
  • Effects were weaker among ex smokers; the smoking-associated ORs remained consistently higher for hyperplastic polyps.
  • Tobacco-associated risks for multiple polyps were also stronger when hyperplastic disease was involved.
  • In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions.
  • [MeSH-major] Adenomatous Polyposis Coli / etiology. Colorectal Neoplasms / etiology. Smoking / adverse effects

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Smoking.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16702367.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  •  go-up   go-down


31. Hwang ST, Cho YK, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Won KH, Jin W: Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. J Gastroenterol Hepatol; 2010 Mar;25(3):562-7
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps.
  • Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver.
  • This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.
  • We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361).
  • RESULTS: The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group.
  • By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60).
  • An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps.
  • CONCLUSION: NAFLD was associated with colorectal adenomatous polyps.
  • Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / complications. Fatty Liver / complications

  • Genetic Alliance. consumer health - Liver Disease.
  • Genetic Alliance. consumer health - Non-alcoholic steatohepatitis (NASH).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20074156.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  •  go-up   go-down


32. Benfatto G, Tenaglia L, Catania G, D'Antoni S, Jiryis A, Centoze D, Garufi SM, Mugavero F, Giovinetto A: Pathological evaluation in colorectal polyps endoscopic treatment. G Chir; 2006 Nov-Dec;27(11-12):411-6
MedlinePlus Health Information. consumer health - Endoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological evaluation in colorectal polyps endoscopic treatment.
  • This retrospective study shows that endoscopic polypectomy is the technique of choice to remove the majority of polyps; follow-up and pathologic examinations shed light on the carcinogenesis of colorectal lesions.
  • From January 1990 to December 2001, 1302 adenomatous polyps were removed, 1175 endoscopically, 127 with surgical procedures.
  • The anatomical and morphologic conditions of the colon and some characteristics of the polyps represent limits to the feasibility and to the efficacy of polypectomy, and the most important variables for the correct management of the patients affected by colorectal adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Endoscopy

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17198549.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


33. Kim CS, Kim MC, Cheong HK, Jeong TH: [The association of obesity and left colonic adenomatous polyps in Korean adult men]. J Prev Med Public Health; 2005 Nov;38(4):415-9
MedlinePlus Health Information. consumer health - Obesity.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The association of obesity and left colonic adenomatous polyps in Korean adult men].
  • OBJECTIVES: We wanted to evaluate the relationship between obesity and left colonic adenomatous polyps in Korean adult men.
  • RESULTS: There were 99 cases of colonic adenomatous polyps.
  • The BMI and WHR were associated with the adenomatous polyps (odds ratio, 1.81 [95% CI=1.02-3.19] for a BMI > or = 25.0 as compared with a BMI < or = 22.9, odds ratio, 3.94 [95% CI = 1.77-8.77] for a WHR > or = 0.95 as compared with a WHR < or = 0.86).
  • The BMI was not associated with the risk of adenomatous polyps after additional adjustment was made for the WHR, but the association between the WHR and adenomatous polyps was still positive and independent of the BMI (odds ratio, 4.15 [95% CI=1.63-10.59]).
  • CONCLUSIONS: The results support that obesity, and particularly abdominal obesity, can be associated with an increased risk of incurring colonic adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / etiology. Colonic Polyps / etiology. Obesity / complications

  • Genetic Alliance. consumer health - Obesity.
  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16358826.001).
  • [ISSN] 1975-8375
  • [Journal-full-title] Journal of preventive medicine and public health = Yebang Ŭihakhoe chi
  • [ISO-abbreviation] J Prev Med Public Health
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  •  go-up   go-down


34. Summers RM, Liu J, Yao J, Brown L, Choi JR, Pickhardt PJ: Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps. AJR Am J Roentgenol; 2009 Nov;193(5):1305-10
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps.
  • OBJECTIVE: Hyperplastic polyps are more difficult to detect than adenomatous polyps at CT colonography (CTC), and it has been theorized that this difference in detectability is because hyperplastic polyps are flatter.
  • Using automated software that computes polyp height, we determined whether hyperplastic colonic polyps on CTC are indeed flatter than adenomatous polyps of comparable width.
  • One hundred eighty-five of the patients had at least one hyperplastic or adenomatous polyp 6-10 mm visible at both OC and CTC, where size was determined by a calibrated guidewire at OC.
  • To assess flatness, the heights of the polyps at CTC were measured using a validated automated software program.
  • The heights and height-to-width ratios of the hyperplastic polyps were compared with those of the adenomatous polyps using a Student's t test (two-tailed, unpaired, unequal variance).
  • RESULTS: There were 176 adenomatous and 83 hyperplastic polyps visible at segment-unblinded OC.
  • The fraction of these polyps that were measurable at CTC using the automated software was not significantly different for adenomatous versus hyperplastic polyps (158/176 [89.8%] vs 73/87 [83.9%], respectively; p = 0.2).
  • The average height-to-width ratios using automated width measurements were 15% less for hyperplastic polyps: 0.39 +/- 0.20 (n = 158) and 0.33 +/- 0.19 (n = 73) for adenomatous and hyperplastic polyps, respectively (p = 0.03).
  • When polyps of comparable OC size or CTC width were considered, the heights of hyperplastic polyps were up to 27% less than those of adenomatous polyps.
  • CONCLUSION: For 6-10 mm polyps of a given size as determined by OC or a given width at CTC, hyperplastic polyps tend to be flatter (i.e., have lower height) compared with adenomatous polyps.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic. Radiographic Image Interpretation, Computer-Assisted / methods
  • [MeSH-minor] Adenomatous Polyps / pathology. Adenomatous Polyps / radiography. Aged. Analysis of Variance. Automation. Colonoscopy. Contrast Media. Female. Humans. Hyperplasia. Male. Middle Aged. Retrospective Studies. Software

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Abdom Imaging. 2002 May-Jun;27(3):292-300 [12173360.001]
  • [Cites] Acad Radiol. 2009 Jan;16(1):4-14 [19064206.001]
  • [Cites] N Engl J Med. 2003 Dec 4;349(23):2191-200 [14657426.001]
  • [Cites] Radiology. 2004 Sep;232(3):784-90 [15247435.001]
  • [Cites] AJR Am J Roentgenol. 2004 Nov;183(5):1343-7 [15505301.001]
  • [Cites] Gastroenterology. 1974 Mar;66(3):347-56 [4813500.001]
  • [Cites] Lancet. 1986 Feb 8;1(8476):307-10 [2868172.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Am J Gastroenterol. 1990 Dec;85(12):1557-9 [2252015.001]
  • [Cites] Gastrointest Endosc. 1991 Jan-Feb;37(1):88-91 [2004689.001]
  • [Cites] Gastrointest Endosc. 1994 Sep-Oct;40(5):588-91 [7988824.001]
  • [Cites] Gastroenterology. 1997 Jan;112(1):24-8 [8978338.001]
  • [Cites] Gastroenterol Clin North Am. 1997 Mar;26(1):85-101 [9119442.001]
  • [Cites] CA Cancer J Clin. 1997 Mar-Apr;47(2):93-112 [9074488.001]
  • [Cites] Radiology. 2005 Jul;236(1):3-9 [15987959.001]
  • [Cites] Am J Gastroenterol. 2006 Feb;101(2):343-50 [16454841.001]
  • [Cites] AJR Am J Roentgenol. 2006 Jun;186(6):1611-7 [16714650.001]
  • [Cites] Radiology. 2007 Jan;242(1):120-8 [17105850.001]
  • [Cites] AJR Am J Roentgenol. 2007 Apr;188(4):945-52 [17377028.001]
  • [Cites] Med Phys. 2007 May;34(5):1655-64 [17555247.001]
  • [Cites] Gastroenterol Clin North Am. 2007 Dec;36(4):947-68, viii [17996799.001]
  • [Cites] Acad Radiol. 2008 Feb;15(2):231-9 [18206622.001]
  • [Cites] JAMA. 2008 Mar 5;299(9):1027-35 [18319413.001]
  • [Cites] Endoscopy. 2008 Apr;40(4):284-90 [18389446.001]
  • [Cites] AJR Am J Roentgenol. 2008 May;190(5):1279-85 [18430844.001]
  • [Cites] N Engl J Med. 2008 Sep 18;359(12):1207-17 [18799557.001]
  • [Cites] Gastrointest Endosc. 2008 Oct;68(4 Suppl):S3-47 [18805238.001]
  • [Cites] AJR Am J Roentgenol. 2003 Sep;181(3):799-805 [12933484.001]
  • (PMID = 19843746.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-05; United States / Intramural NIH HHS / / Z01 CL040003-06; United States / Intramural NIH HHS / / ZIA CL040003-07; United States / Intramural NIH HHS / / ZIA CL040003-08; United States / Intramural NIH HHS / / ZIA CL040003-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ NIHMS394801; NLM/ PMC3412299
  •  go-up   go-down


35. Barreda Costa C, Vila Gutierrez S, Salazar Cabrera F, Barriga Calle E, Velarde Criado H, Barriga Briceño J: [Advanced adenoma in 3700 colonoscopies]. Rev Gastroenterol Peru; 2010 Apr-Jun;30(2):113-20
MedlinePlus Health Information. consumer health - Colonoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Advanced adenoma in 3700 colonoscopies].
  • OBJECTIVES: To determine the prevalence of colon polyps, distribution in the colon, as well as their histological characteristics, with special mention on advanced adenomas, in an adult population at an endoscopy center in Lima.
  • Each polyp was studied separately and its histological findings recorded.
  • RESULTS: 3,701 colonoscopies were done in 3,690 patients; 1,492 (40,4%) had polyps and were included in the study.
  • 997 (27%) had adenomatous polyps and 495 (13.4%) non adenomatous polyps.
  • Adenomatous polyps were found throughout the colon, with a predominance of hyperplasic polyps in the rectum.
  • 78% of the adenomatous polyps and 84% of the advanced adenomas were found in patients older than 50 years old.
  • In this group of patients, significant risk factors were: prior history of adenomas or colorectal cancer (46/203 vs. 63/495; p<0.01), and multiple adenomatous polyps found during colonoscopy (67/203 vs. 121/794; p<0.01).
  • CONCLUSIONS: Adenomatous polyps were the most frequently found polyps in our study; approximately 20% were advanced lesions, especially in patients older than 50 years old.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Colonoscopy / statistics & numerical data. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / epidemiology. Adenomatous Polyps / pathology. Adult. Age Factors. Aged. Aged, 80 and over. Early Diagnosis. Humans. Hyperplasia. Middle Aged. Motivation. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / pathology. Organ Specificity. Peru / epidemiology. Prospective Studies. Young Adult

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20644602.001).
  • [ISSN] 1609-722X
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
  •  go-up   go-down


36. Osadchuk AM, Osadchuk MA, Kvetnoĭ IM: [The role of some cell regeneration markers of epithelial cells in genesis of gastric tumors associated with H. pylori]. Klin Med (Mosk); 2008;86(5):33-8
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is established, that chronic atrophic gastritis adenomatous polyps and gastric cancer are consecutive stages of gastric mucous tunic cell renovation disturbance, manifests itself in progressive delay its apoptosis activity from proliferation, which reflects increase in expression Ki-67 and Bcl-2.
  • [MeSH-minor] Biomarkers, Tumor / biosynthesis. Biopsy. Disease Progression. Epithelial Cells / metabolism. Epithelial Cells / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / biosynthesis. Precancerous Conditions. Proto-Oncogene Proteins c-bcl-2 / biosynthesis

  • MedlinePlus Health Information. consumer health - Helicobacter Pylori Infections.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18589715.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2
  •  go-up   go-down


37. Grahn SW, Varma MG: Factors that increase risk of colon polyps. Clin Colon Rectal Surg; 2008 Nov;21(4):247-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors that increase risk of colon polyps.
  • Adenomatous polyps are common and factors that increase risk include race, gender, smoking, and obesity.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Jpn J Cancer Res. 1994 May;85(5):479-84 [8014105.001]
  • [Cites] Cancer Causes Control. 1994 May;5(3):215-20 [8061168.001]
  • [Cites] J Natl Cancer Inst. 1994 Feb 2;86(3):192-9 [8283491.001]
  • [Cites] Epidemiology. 1996 May;7(3):275-80 [8728441.001]
  • [Cites] CA Cancer J Clin. 1997 Jan-Feb;47(1):5-27 [8996076.001]
  • [Cites] Cancer. 1997 Jul 15;80(2):193-7 [9217029.001]
  • [Cites] Am J Epidemiol. 1998 Apr 1;147(7):670-80 [9554606.001]
  • [Cites] Scand J Gastroenterol. 1987 Jan;22(1):13-6 [3563406.001]
  • [Cites] Am J Gastroenterol. 2005 Dec;100(12):2756-8 [16393231.001]
  • [Cites] BMC Gastroenterol. 2006;6:5 [16412216.001]
  • [Cites] Am J Gastroenterol. 2006 Apr;101(4):823-30 [16494591.001]
  • [Cites] Clin Gastroenterol Hepatol. 2006 Oct;4(10):1225-31 [16979948.001]
  • [Cites] J Cancer Educ. 2006 Spring;21(1 Suppl):S32-6 [17020499.001]
  • [Cites] Arch Med Res. 2007 Jul;38(5):519-25 [17560457.001]
  • [Cites] J Natl Med Assoc. 2007 Jul;99(7):723-8 [17668638.001]
  • [Cites] J Natl Med Assoc. 2007 Jul;99(7):733-48 [17668639.001]
  • [Cites] Gastroenterology. 2008 Feb;134(2):388-95 [18242207.001]
  • [Cites] Lancet. 2008 Feb 16;371(9612):569-78 [18280327.001]
  • [Cites] J Intern Med. 2008 Apr;263(4):336-52 [18312311.001]
  • [Cites] Scand J Gastroenterol. 1991 Jul;26(7):758-62 [1896819.001]
  • [Cites] J Natl Med Assoc. 1991 Aug;83(8):730-2 [1956086.001]
  • [Cites] J Natl Cancer Inst. 1991 Mar 6;83(5):359-61 [1995919.001]
  • [Cites] Am J Public Health. 1991 Jul;81(7):846-9 [2053658.001]
  • [Cites] Gastroenterology. 1989 Sep;97(3):660-4 [2753326.001]
  • [Cites] Dis Colon Rectum. 1988 Apr;31(4):258-60 [3359894.001]
  • [Cites] Ann Intern Med. 1995 Mar 1;122(5):327-34 [7847643.001]
  • [Cites] N Engl J Med. 1993 Dec 30;329(27):1977-81 [8247072.001]
  • [Cites] Gastroenterology. 1993 Jan;104(1):137-44 [8419236.001]
  • [Cites] Am J Epidemiol. 1998 May 15;147(10):903-10 [9596467.001]
  • [Cites] Adv Exp Med Biol. 1994;366:269-89 [7771258.001]
  • [Cites] Am J Gastroenterol. 2003 Dec;98(12):2648-54 [14687811.001]
  • [Cites] Int J Obes Relat Metab Disord. 2004 Apr;28(4):559-67 [14770200.001]
  • [Cites] J Gen Intern Med. 2004 Apr;19(4):332-8 [15061742.001]
  • [Cites] Arch Med Res. 2004 May-Jun;35(3):215-9 [15163462.001]
  • [Cites] Am J Gastroenterol. 2005 Mar;100(3):515-23; discussion 514 [15743345.001]
  • [Cites] Med Clin North Am. 2005 Jul;89(4):771-93 [15925649.001]
  • [Cites] Int J Colorectal Dis. 2006 Apr;21(3):201-8 [15959790.001]
  • [Cites] Ann Hum Biol. 2005 Jul-Aug;32(4):513-24 [16147399.001]
  • [Cites] Cancer. 2005 Dec 15;104(12 Suppl):2940-7 [16276538.001]
  • [Cites] J Nutr Biochem. 2006 Mar;17(3):145-56 [16426829.001]
  • [Cites] Am J Prev Med. 2006 Apr;30(4):320-6 [16530619.001]
  • [Cites] Prev Chronic Dis. 2006 Apr;3(2):A50 [16539791.001]
  • [Cites] Cancer Res. 2006 Apr 1;66(7):3942-53 [16585224.001]
  • [Cites] Gastrointest Endosc. 2006 Nov;64(5):751-9 [17055869.001]
  • [Cites] Arch Intern Med. 2007 Feb 12;167(3):258-64 [17296881.001]
  • [Cites] J Womens Health (Larchmt). 2007 Jan-Feb;16(1):57-65 [17324097.001]
  • [Cites] Dis Colon Rectum. 1999 Mar;42(3):337-42 [10223753.001]
  • [Cites] Jpn J Cancer Res. 1999 Aug;90(8):805-11 [10543250.001]
  • [Cites] Gastroenterology. 2001 Mar;120(4):848-56 [11231939.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2001 Jul;10(7):725-31 [11440957.001]
  • [Cites] Am J Gastroenterol. 2001 Jul;96(7):2238-46 [11467659.001]
  • [Cites] J Nutr. 2001 Nov;131(11 Suppl):3109S-20S [11694656.001]
  • [Cites] Am J Clin Nutr. 2002 Apr;75(4):767-72 [11916766.001]
  • [Cites] Gut. 2002 Aug;51(2):191-4 [12117878.001]
  • [Cites] Ann Intern Med. 2002 Jul 16;137(2):132-41 [12118972.001]
  • [Cites] Curr Opin Clin Nutr Metab Care. 2002 Sep;5(5):551-9 [12172480.001]
  • [Cites] Am J Gastroenterol. 2002 Aug;97(8):2100-2 [12190183.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):1006-11 [14578135.001]
  • [Cites] JAMA. 2003 Dec 10;290(22):2959-67 [14665657.001]
  • [Cites] Cancer. 2004 Dec 1;101(11):2523-32 [15505783.001]
  • [Cites] N Engl J Med. 2005 May 19;352(20):2061-8 [15901859.001]
  • [Cites] Gastroenterology. 2005 Aug;129(2):464-75 [16083703.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2082-6 [16172213.001]
  • [Cites] Health Promot Pract. 2005 Oct;6(4):369-78 [16210678.001]
  • [Cites] Clin Gastroenterol Hepatol. 2005 Aug;3(8):798-805 [16234009.001]
  • [Cites] Am J Gastroenterol. 2005 Dec;100(12):2749-55 [16393230.001]
  • [Cites] J Clin Gastroenterol. 2007 Mar;41(3):285-90 [17426468.001]
  • [Cites] Cancer Detect Prev. 2007;31(2):161-5 [17433566.001]
  • [Cites] Am J Health Behav. 2007 Sep-Oct;31(5):502-13 [17555381.001]
  • [Cites] Pol Merkur Lekarski. 2007 May;22(131):373-5 [17679371.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1543-6 [17684126.001]
  • [Cites] J Gastroenterol. 2007 Aug;42(8):616-23 [17701124.001]
  • (PMID = 20011435.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780253
  • [Keywords] NOTNLM ; Polyps / epidemiology / risk factors
  •  go-up   go-down


38. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA: Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol; 2007 Jan-Mar;44(1):14-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies.
  • BACKGROUND: Gastric polyps are small gastric lesions, asymptomatic in most cases and are generally discovered inadvertently during upper digestive endoscopy.
  • AIM: To retrospectively review the characteristics and frequency of gastric polyps, derived from the gastric mucosal epithelium in a large series of endoscopies.
  • All patients had at least one gastric polyp, as confirmed by histological examination.
  • RESULTS: The polyps were classified as hyperplastic, adenomatous and fundic gland polyps.
  • The most of them measure less than 1 cm (hyperplastic polyps - 60,5%; adenomatous polyps - 73,6%; fundic gland polyps - 72%).
  • Hyperplastic polyps were the most frequent and accounted for 71.3% of the cases, whereas fundic gland polyps accounted for 16.3% and adenomatous polyps for 12.4%.
  • Hyperplastic and adenomatous polyps were primarily single, whereas fundic gland polyps tended to be multiple.
  • A carcinoma was detected in one hyperplastic polyp (0.9%) and in two adenomatous polyps (10.5%).
  • High grade dysplastic foci were found in four adenomatous polyps (21%).
  • CONCLUSIONS: The digestive endoscopy is the safest and efficient method for the diagnosis of the gastric polyps, that in most of the patients does not show characteristic symptoms.
  • The histopathological definition is not possible to the endoscopic glance being needed the pathologist's aid, once the conduct to be adopted will depend on the result of the biopsy.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Adult. Aged. Aged, 80 and over. Female. Gastric Fundus. Gastroscopy. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - Stomach Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17639176.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  •  go-up   go-down


39. Vakhrushev IaM, Kniazeva BG: [The peculiarities of the contents of the gastric mucus in patients with gastric polyps]. Klin Med (Mosk); 2007;85(4):49-52
MedlinePlus Health Information. consumer health - Stomach Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The peculiarities of the contents of the gastric mucus in patients with gastric polyps].
  • Complex study of the components of the gastric mucus in 60 patients with gastric polyps was studied.
  • The degree of the changes in the gastric mucus was higher in patients with adenomatous polyps vs. hyperplastic ones.
  • [MeSH-major] Gastric Mucosa / pathology. Mucus. Polyps / pathology. Stomach Diseases / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17564039.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Glycosaminoglycans
  •  go-up   go-down


40. Elabsi M, Amraoui M, Elouannani M, Echarab M, Elalami el HF, Errougani A, Chkof MR: Colorectal intussusception secondary to sigmoid carcinoma in an adult. South Med J; 2007 Oct;100(10):1039-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although intussusception is relatively common in children, it is clinically rare in adults A 54-year-old woman who presented with cramping abdominal pain and rectal bleeding was found to have sigmoid rectal intussusception secondary to adenomatous polyps of the sigmoid colon.
  • [MeSH-minor] Adenomatous Polyps / complications. Female. Humans. Middle Aged. Rectum / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] South Med J. 2007 Oct;100(10):973-4 [17943038.001]
  • (PMID = 17943052.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


41. Casadesus D: Surgical resection of rectal adenoma: a rapid review. World J Gastroenterol; 2009 Aug 21;15(31):3851-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical resection of rectal adenoma: a rapid review.
  • Transanal excision (TE), endoscopic transanal resection (ETAR) and transanal endoscopic microsurgery (TEM) can be used to remove adenomatous polyps.
  • [MeSH-major] Adenoma. Anastomosis, Surgical. Rectal Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Orv Hetil. 1999 Oct 3;140(40):2215-9 [10540895.001]
  • [Cites] Dis Colon Rectum. 2008 Jul;51(7):1026-30; discussion 1030-1 [18481147.001]
  • [Cites] ANZ J Surg. 2002 Dec;72(12):854-6 [12485218.001]
  • [Cites] World J Surg. 2003 Feb;27(2):197-202 [12616436.001]
  • [Cites] Dis Colon Rectum. 2003 Oct;46(10):1345-50 [14530673.001]
  • [Cites] Ann Surg Oncol. 2003 Nov;10(9):1106-11 [14597451.001]
  • [Cites] Dis Colon Rectum. 2004 Jan;47(1):86-9 [14702647.001]
  • [Cites] Surg Endosc. 2003 Sep;17(9):1461-3 [12739115.001]
  • [Cites] JSLS. 2004 Apr-Jun;8(2):123-6 [15119655.001]
  • [Cites] J Gastroenterol Hepatol. 2004 Jul;19(7):767-72 [15209623.001]
  • [Cites] Int J Colorectal Dis. 2004 Nov;19(6):569-73 [15103489.001]
  • [Cites] Nouv Presse Med. 1974 May 25;3(21):1365-6 [4848702.001]
  • [Cites] Chirurg. 1977 May;48(5):343-4 [862483.001]
  • [Cites] Chirurg. 1984 Oct;55(10):677-80 [6510078.001]
  • [Cites] Dis Colon Rectum. 1991 Oct;34(10):880-5 [1914721.001]
  • [Cites] Br J Surg. 1993 Jun;80(6):788-93 [8330178.001]
  • [Cites] Br J Surg. 1993 Nov;80(11):1401-4 [8252348.001]
  • [Cites] Helv Chir Acta. 1994 Apr;60(4):599-604 [8034540.001]
  • [Cites] Surg Endosc. 1995 Oct;9(10):1106-12 [8553213.001]
  • [Cites] Harefuah. 1995 Oct;129(7-8):236-7, 295 [8549959.001]
  • [Cites] Br J Surg. 1996 Feb;83(2):207-10 [8689164.001]
  • [Cites] Langenbecks Arch Surg. 1998 Oct;383(5):320-4 [9860223.001]
  • [Cites] Colorectal Dis. 2005 Jan;7(1):47-50 [15606584.001]
  • [Cites] Colorectal Dis. 2005 Mar;7(2):133-7 [15720349.001]
  • [Cites] Chirurg. 2005 Apr;76(4):379-84 [15502890.001]
  • [Cites] Dig Surg. 2005;22(3):182-9; discussion 189-90 [16137996.001]
  • [Cites] Dis Colon Rectum. 2006 Feb;49(2):228-32 [16322965.001]
  • [Cites] Dig Liver Dis. 2006 Mar;38(3):202-7 [16461025.001]
  • [Cites] Ann Surg Oncol. 2006 Apr;13(4):547-56 [16514476.001]
  • [Cites] Colorectal Dis. 2006 Sep;8(7):581-5 [16919110.001]
  • [Cites] Colorectal Dis. 2006 Nov;8(9):795-9 [17032328.001]
  • [Cites] Tech Coloproctol. 2006 Dec;10(4):277-81 [17115311.001]
  • [Cites] Br J Surg. 2007 May;94(5):627-33 [17335125.001]
  • [Cites] Am J Surg. 2007 Nov;194(5):694-8 [17936438.001]
  • [Cites] Ann Surg. 2002 Mar;235(3):355-62 [11882757.001]
  • (PMID = 19701964.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 41
  • [Other-IDs] NLM/ PMC2731246
  •  go-up   go-down


42. Dhar A, Johnson KS, Novelli MR, Bown SG, Bigio IJ, Lovat LB, Bloom SL: Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique. Gastrointest Endosc; 2006 Feb;63(2):257-61
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We assessed the diagnostic potential of ESS in the colon to differentiate normal colonic mucosa, chronic colitis, hyperplastic polyps, adenomatous polyps (with dysplasia), and adenocarcinoma.
  • They were then compared with conventional biopsy specimens taken from the same site, including normal colonic mucosa, hyperplastic polyps, adenomatous polyps, chronic colitis, and colon cancer.
  • RESULTS: A total of 483 spectra were analyzed (290 normal, 19 hyperplastic, 69 adenomatous polyps, 74 chronic colitis, and 31 colorectal cancer).
  • The sensitivity and the specificity of differentiating adenomas from hyperplastic polyps was 84% and 84%, respectively; for cancer from adenomatous polyps, 80% and 75%, respectively; for colitis from normal tissue, 77% and 82%, respectively; and for dysplastic mucosa (from polyps) from colitis, 85% and 88%, respectively.
  • It could prove a valuable aid for targeting biopsies in dysplasia surveillance in inflammatory bowel disease and for deciding which small polyps should be removed.

  • MedlinePlus Health Information. consumer health - Biopsy.
  • MedlinePlus Health Information. consumer health - Colonic Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16427931.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


43. Burke CA: Colonic complications of obesity. Gastroenterol Clin North Am; 2010 Mar;39(1):47-55
MedlinePlus Health Information. consumer health - Obesity.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Obesity is a risk factor for colorectal cancer and adenomatous polyps.
  • [MeSH-minor] Adenoma / epidemiology. Animals. Body Mass Index. Colonoscopy. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / physiopathology. Comorbidity. Diverticulitis, Colonic / epidemiology. Humans. Insulin Resistance / physiology. Intra-Abdominal Fat / physiopathology. Leptin / physiology. Metabolic Syndrome X / epidemiology. Metabolic Syndrome X / physiopathology

  • Genetic Alliance. consumer health - Obesity.
  • MedlinePlus Health Information. consumer health - Colonic Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20202578.001).
  • [ISSN] 1558-1942
  • [Journal-full-title] Gastroenterology clinics of North America
  • [ISO-abbreviation] Gastroenterol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin
  •  go-up   go-down


44. Moreira LR, Schenka AA, Filho PL, Lima CS, Trevisan MA, Vassallo J: Comparison of blood neoangiogenesis and lymphatic vascularization in colorectal adenomas from patients with and without concomitant colorectal cancer. Braz J Med Biol Res; 2009 Jul;42(7):593-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most colorectal carcinomas develop from adenomas (adenoma-carcinoma sequence) in a process due to accumulation of molecular genetic alterations.
  • About 5% of adenomatous polyps are expected to become malignant, but data on the differential angiogenic patterns of these lesions in patients with and without concomitant cancer are missing.
  • The aim of the present study is to compare the angiogenic and lymphatic patterns of adenomatous polyps from patients with and without sporadic cancer.
  • Thirty adenomatous polyps (15 from patients with another principal malignant lesion, and 15 from patients without cancer) were submitted to immunohistochemical staining for CD105 (marker for neoangiogenesis) and D2-40 (marker for lymphatic endothelium).

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19466284.001).
  • [ISSN] 1414-431X
  • [Journal-full-title] Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • [ISO-abbreviation] Braz. J. Med. Biol. Res.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD; 0 / Biomarkers; 0 / ENG protein, human; 0 / Receptors, Cell Surface; 0 / monoclonal antibody D2-40
  •  go-up   go-down


45. Lee GE, Park HS, Yun KE, Jun SH, Kim HK, Cho SI, Kim JH: Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men. Obesity (Silver Spring); 2008 Jun;16(6):1434-9
MedlinePlus Health Information. consumer health - Metabolic Syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men.
  • Adenomatous colonic polyps are precancerous lesions of colon cancer.
  • We investigated whether BMI and the metabolic syndrome are associated with the presence of adenomatous colonic polyps in Korean men.
  • Multiple logistic regression analysis was used to evaluate the association between BMI and the metabolic syndrome and adenomatous polyps.
  • Compared with men in the 1st quintile of the BMI, the adjusted odds ratio (OR) and 95% confidence interval (CI) for adenomatous polyps in men in the 2nd, 3rd, 4th, and 5th quintiles of the BMI were 1.55 (1.10-2.19), 1.57 (1.10-2.24), 1.94 (1.34-2.81), and 1.99 (1.31-3.01), respectively (P for trend <0.0001).
  • Men with triglycerides (TGs) > or = 150 mg/dl were significantly more likely to have adenomatous polyps than were men with TG <150 mg/dl (OR 1.29; 95% CI 1.03-1.62).
  • As a function of the number of metabolic risk factors, the ORs for adenomatous polyps were 1.41 (1.03-1.93), 1.52 (1.08-2.12), 1.46 (1.01-2.12), and 1.77 (1.08-2.90) for 1, 2, 3, and > or = 4 risk factors, respectively (P for trend <0.05).
  • Adenomatous colonic polyps were significantly associated with increased BMI levels.
  • Subjects with even one component of the metabolic syndrome had a significantly higher risk for developing adenomatous polyps compared to those subjects without any component in Korean men.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Body Mass Index. Colonic Polyps / epidemiology. Metabolic Syndrome X / physiopathology

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18388894.001).
  • [ISSN] 1930-7381
  • [Journal-full-title] Obesity (Silver Spring, Md.)
  • [ISO-abbreviation] Obesity (Silver Spring)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Triglycerides
  •  go-up   go-down


46. Parra V, Watanabe J, Nago A, Astete M, Rodríguez C, Valladares G, Nuñez N, Yoza M, Gargurevich T, Pinto Sánchez J: [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy]. Rev Gastroenterol Peru; 2009 Oct-Dec;29(4):326-31
MedlinePlus Health Information. consumer health - Colonoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy].
  • [Transliterated title] Papel del Endoscopista en la Detección de Pólipos Adenomatosos Durante la Colonoscopia.
  • INTRODUCTION: Age, gender and indication for the examination are known predictors of adenomatous polyp detection during colonoscopy.
  • OBJECTIVES: To determine the role of the endoscopist in detecting adenomatous polyps during colonoscopy MATERIAL AND METHODS: Is retrospective cross-sectional correlational study.
  • Statistical analysis showed significant differences between endoscopists regarding the detection rate of adenomatous polyps (p = 0.038).
  • The range for the detection of at least 1 adenomatous polyp by colonoscopy was 14,6-30,0%.
  • In patients over 50 years, there were also significant differences between endoscopists in detection rate of adenomatous polyps (p = 0.001).
  • The range for the detection of at least 1 adenomatous polyp was 18,2-37,5% in that group.Also found that age and gender were powerful predictors of adenomatous polyps, both for the total cohort, and patients older than 50 years.
  • Regarding the indication for colonoscopy, no significant difference between the categories, were found p = 0.288 CONCLUSION S: The endoscopist is as or more important than age, gender or indication for the examination, in predicting the detection of adenomatous polyps during colonoscopy.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonoscopy / standards

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20066017.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
  •  go-up   go-down


47. Bafandeh Y, Daghestani D, Esmaili H, Aharizad S: Distribution of cancer and adenomatous polyps in the colorectum: study in an Iranian population. Asian Pac J Cancer Prev; 2006 Jan-Mar;7(1):65-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distribution of cancer and adenomatous polyps in the colorectum: study in an Iranian population.
  • OBJECTIVE: There is consensus that the majority of colorectal carcinomas (CRCs) arise from adenomatous polyps.
  • If the same etiologic factors are operating for polyps and cancers their anatomical distributions should be the same.
  • MATERIALS AND METHODS: We reviewed, retrospectively , endoscopically reported anatomic sites of all adenomatous polyps and CRCs which were histologically confirmed from Jan 1992 to Dec 2005 in Tabriz, the North-west of Iran.
  • One hundred and forty-three CRC's and 180 adenomatous polyps (in 145 patients) were found.
  • Age and sex of patients, size and anatomic sites of polyps and cancers were studied.
  • In both cancer and adenoma cases the most common presenting symptoms were rectal bleeding and bloody diarrhea ( 52.4% , 16.9% and 39.2% , 15.8% for cancers and adenomas, respectively) without any significant difference(0>05).
  • The propensity for polyps to be found in the descending colon was of borderline significance (p=0.07).
  • The cecal segment uniquely demonstrated cancers(p=0.01) without any polyps.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / epidemiology. Adenomatous Polyposis Coli / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16629518.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
  •  go-up   go-down


48. Colao A, Pivonello R, Auriemma RS, Galdiero M, Ferone D, Minuto F, Marzullo P, Lombardi G: The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients. J Clin Endocrinol Metab; 2007 Oct;92(10):3854-60
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Our objective was to evaluate the role of fasting insulin levels on the prevalence of colonic adenomatous polyps or adenocarcinoma in acromegaly.
  • RESULTS: Colonic lesions were found in 81 patients (38.6%), and consisted of hyperplastic polyps in 33 (15.7%), adenomatous polyps in 42 (20.0%), and adenocarcinoma in six patients (2.8%).
  • Polyps were single in 22 cases (27.1%).
  • Fasting insulin levels were significantly lower in patients without lesions (16.0 +/- 7.5 mU/liter) than in patients with hyperplastic polyps (22.4 +/- 8.8 mU/liter; P < 0.01), adenomatous polyps (38.0 +/- 15.9 mU/liter; P < 0.0001), and adenocarcinoma (59.0 +/- 30.6 mU/liter; P < 0.0001).
  • Fasting insulin levels were also lower in patients with hyperplastic polyps than in those with adenomatous polyps (P < 0.01).
  • [MeSH-major] Acromegaly / epidemiology. Adenocarcinoma / epidemiology. Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Insulin / blood

  • Genetic Alliance. consumer health - Acromegaly.
  • MedlinePlus Health Information. consumer health - Diabetes Medicines.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17652220.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I
  •  go-up   go-down


49. Buecher B, Laurent-Puig P: [Prophylactic colectomy in hereditary colorectal cancer]. Rev Prat; 2008 Jun 30;58(12):1281-5
Genetic Alliance. consumer health - Hereditary Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colectomy should be considered when these lesions are not amenable to endoscopic resection because of their morphological characteristics and/or their multiplicity.
  • In fact, colectomy or coloproctectomy is indicated in virtually all patients with classical form of familial adenomatous polyposis as they develop hundreds of adenomatous polyps during their second decade of live.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Colectomy. Colorectal Neoplasms, Hereditary Nonpolyposis / surgery

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18714645.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 22
  •  go-up   go-down


50. Hsu WH, Wu IC, Kuo CH, Su YC, Lu CY, Kuo FC, Jan CM, Wang WM, Wu DC, Yu FJ: Influence of proton pump inhibitor use in gastrointestinal polyps. Kaohsiung J Med Sci; 2010 Feb;26(2):76-83
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of proton pump inhibitor use in gastrointestinal polyps.
  • However, because hypergastrinemia is related to the occurrence of colonic adenomatous polyps, the purpose of this study was to analyze the relationship between the occurrence of gastrointestinal polyps and hypergastrinemia induced by PPIs.
  • Any subtle polypoid lesions in the stomach and colon were sampled by biopsy for histological examination.
  • A total of 122 patients were receiving PPI treatment for either peptic ulcer disease or reflux esophagitis and were included as the study group.
  • The remaining 137 patients were not treated with PPIs and served as the non-PPI group.
  • Although the prevalence of gastric gland polyps was higher in the PPI group (65.6% vs. 37.2%, p < 0.001), there was no difference in the prevalence of colonic adenomatous polyps observed (22.13% vs. 22.62%, p = 0.928).
  • In conclusion, the prevalence of gastric polyps, particularly fundic gland polyps, was higher among PPI users.
  • However, the prevalence of colonic polyps was not affected by PPI use, regardless of past history of colonic adenomatous polyps.
  • [MeSH-major] Anti-Ulcer Agents / adverse effects. Gastrointestinal Diseases / drug therapy. Polyps / drug therapy. Proton Pump Inhibitors / adverse effects

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20123595.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Proton Pump Inhibitors
  •  go-up   go-down


51. Fearnhead NS, Winney B, Bodmer WF: Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model. Cell Cycle; 2005 Apr;4(4):521-5
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Each variant confers a moderate, but detectable, increase in relative risk of developing the disease.
  • Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Genetic Predisposition to Disease
  • [MeSH-minor] Adenomatous Polyps / pathology. Base Pair Mismatch. DNA Repair. Disease Susceptibility. Genetic Variation. Humans. Intestinal Polyps. Multifactorial Inheritance. Risk. Wnt Proteins / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15753653.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins
  • [Number-of-references] 62
  •  go-up   go-down


52. Liu YH, Lin J, Guo J, You ZJ, Wang ZG, Zhong D, Yang XL, Zhang ZS, Xiao B, Guo WY: [Detection of interferon-induced transmembrane-1 gene expression for clinical diagnosis of colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Nov;28(11):1950-3
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Semi-quantitative RT-PCR was performed to detect IFITM1 mRNA expression in the specimens of normal colonic mucosa, CRC tissue, inflammatory polyps, adenomatous polyps, gastric cancer, esophageal carcinoma and liver cancer tissues.
  • RESULTS: IFITM1 mRNA was expressed in 47.4 % (18/38) of the CRC specimens, a rate significantly higher than that in adenomatous polyps [15% (3/20)] and gastric cancer [4.8% (1/21)]; no obvious IFITM1 expression was found in normal colonic mucosa, inflammatory polyp, esophageal carcinoma or liver cancer tissues (P<0.001 or P<0.05).
  • IFITM1 mRNA was strongly expressed in CRC at the expression level of 0.8048-/+0.2273, which was significantly higher than that in adenomatous polyps (0.4447-/+0.0989, P<0.001).
  • No antibody response was detected in esophageal carcinoma, liver cancer, inflammatory polyp or adenomatous polyps.

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • Genetic Alliance. consumer health - Colorectal cancer 1.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19033100.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Differentiation; 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / leu-13 antigen
  •  go-up   go-down


53. Patel BB, Yu Y, Du J, Levi E, Phillip PA, Majumdar AP: Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer. Biochem Biophys Res Commun; 2009 Jan 16;378(3):344-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The present study examines the presence of cancer stem-like cells (CSC) in adenomatous polyps and in normal appearing colonic mucosa in humans during aging.
  • The number of polyps was found to increase linearly with advancing age (r(2)=0.92, p<0.02).
  • Immunohistochemical analysis revealed co-localization of CSC markers CD44 and CD166 in colonic polyps.
  • Real-time RT-PCR analysis of normal appearing mucosa from subjects with adenomatous polyps showed an age-related rise in CSC as evidenced by the increased expression of CD44, CD166 and ESA.
  • In addition, the expression each CSC marker was found to be about 2-fold higher in subjects with 3-4 polyps than those with 1-2 polyps.
  • In conclusion, our results show that colon cancer stem-like cells are present in the premalignant adenomatous polyps as well in normal appearing colonic mucosa.

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Mech Ageing Dev. 2001 Oct;122(15):1849-64 [11557285.001]
  • [Cites] N Engl J Med. 2006 Sep 21;355(12):1253-61 [16990388.001]
  • [Cites] World J Gastroenterol. 2006 Dec 14;12(46):7440-50 [17167831.001]
  • [Cites] Br J Cancer. 2008 Aug 5;99(3):387-91 [18665178.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63 [17548814.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1215-22 [17932228.001]
  • [Cites] World J Gastroenterol. 2008 Jul 28;14(28):4492-8 [18680228.001]
  • [Cites] Nature. 2007 Jan 4;445(7123):106-10 [17122772.001]
  • (PMID = 19010307.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / AG014343; United States / NIA NIH HHS / AG / AG014343-11; United States / NIA NIH HHS / AG / R01 AG014343; United States / NIA NIH HHS / AG / R01 AG014343-11; United States / NIA NIH HHS / AG / R01 AG014343-10A1; United States / NIA NIH HHS / AG / AG014343-10A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALCAM protein, human; 0 / Antigens, CD; 0 / Antigens, CD44; 0 / Cell Adhesion Molecules, Neuronal; 0 / Fetal Proteins
  • [Other-IDs] NLM/ NIHMS89453; NLM/ PMC2644999
  •  go-up   go-down


54. Meng W, Cai SR, Zhou L, Dong Q, Zheng S, Zhang SZ: Performance value of high risk factors in colorectal cancer screening in China. World J Gastroenterol; 2009 Dec 28;15(48):6111-6
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The iFOBT had the highest sensitivity, lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.
  • A history of chronic cholecystitis or cholecystectomy, chronic appendicitis or appendectomy, and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and adenomas.
  • The sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for non-adenomatous polyps.
  • A history of chronic appendicitis or appendectomy, chronic constipation, chronic diarrhea, mucous and bloody stool, CRC in first degree relatives, malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous polyps.
  • Except for a history of malignant tumor in screening for non-adenomatous polyps, the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra abnormality.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma / diagnosis. Colonic Polyps / diagnosis. Colorectal Neoplasms / diagnosis. Mass Screening

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Gastroenterol. 2005 Aug;100(8):1813-20 [16086719.001]
  • [Cites] J Clin Epidemiol. 1997 Nov;50(11):1211-7 [9393377.001]
  • [Cites] Cancer Detect Prev. 2007;31(1):3-11 [17289293.001]
  • [Cites] CA Cancer J Clin. 2007 Mar-Apr;57(2):90-104 [17392386.001]
  • [Cites] Gut. 2007 Jul;56(7):965-7 [17303595.001]
  • [Cites] Gastroenterology. 2007 Jun;132(7):2304-12 [17570205.001]
  • [Cites] Gut. 2008 Aug;57(8):1166-76 [18628378.001]
  • [Cites] World J Gastroenterol. 2009 Mar 7;15(9):1085-92 [19266601.001]
  • [Cites] World J Gastroenterol. 2009 Aug 21;15(31):3920-5 [19701973.001]
  • [Cites] J Natl Cancer Inst. 2000 Apr 5;92(7):557-63 [10749911.001]
  • [Cites] N Engl J Med. 2000 Jul 20;343(3):169-74 [10900275.001]
  • [Cites] N Engl J Med. 2001 Aug 23;345(8):607-8 [11529216.001]
  • [Cites] Gastroenterology. 2001 Sep;121(3):542-7 [11522737.001]
  • [Cites] CA Cancer J Clin. 2001 Jan-Feb;51(1):38-75; quiz 77-80 [11577479.001]
  • [Cites] J Clin Microbiol. 2001 Nov;39(11):3927-37 [11682509.001]
  • [Cites] Ann Oncol. 2002 Jan;13(1):40-3 [11863108.001]
  • [Cites] Gut. 2002 Aug;51(2):207-11 [12117881.001]
  • [Cites] Gut. 2002 Oct;51 Suppl 5:V21-7 [12221036.001]
  • [Cites] Dis Colon Rectum. 2003 Jan;46(1):51-8 [12544522.001]
  • [Cites] Br J Cancer. 2003 Jan 13;88(1):79-83 [12556963.001]
  • [Cites] Clin Gastroenterol Hepatol. 2004 Jan;2(1):1-8 [15017625.001]
  • [Cites] Rom J Gastroenterol. 2004 Sep;13(3):187-93 [15470530.001]
  • [Cites] Gut. 1980 Dec;21(12):1090-2 [7461469.001]
  • [Cites] Histopathology. 1983 Sep;7(5):719-28 [6195073.001]
  • [Cites] Gut. 1986 Oct;27(10):1181-5 [3781331.001]
  • [Cites] Am J Epidemiol. 1987 Apr;125(4):672-8 [3826045.001]
  • [Cites] Cell. 1990 Jun 1;61(5):759-67 [2188735.001]
  • [Cites] Gastroenterol Clin Biol. 1991;15(8-9):594-9 [1752369.001]
  • [Cites] Gastroenterology. 1993 Jul;105(1):130-41 [8514030.001]
  • [Cites] Scand J Gastroenterol. 1996 Feb;31(2):160-9 [8658039.001]
  • [Cites] J Med Screen. 1996;3(2):63-5 [8849761.001]
  • [Cites] Epidemiology. 1997 Jan;8(1):104-6 [9116081.001]
  • [Cites] Gut. 2007 Feb;56(2):210-4 [16891354.001]
  • (PMID = 20027686.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2797670
  •  go-up   go-down


55. Peters MB Jr, Obermeyer RJ, Ojeda HF, Knauer EM, Millie MP, Ertan A, Cooper S, Sweeney JF: Laparoscopic management of colonic lipomas: a case report and review of the literature. JSLS; 2005 Jul-Sep;9(3):342-4
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colonic lipomas are infrequent lesions, yet they are the second most common benign lesions of the colon after benign adenomatous polyps.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Gastroenterol. 2000 Aug;95(8):2143-4 [10950091.001]
  • [Cites] Surgery. 1964 Jun;55:773-81 [14167997.001]
  • [Cites] Gastrointest Endosc. 2002 Jun;55(7):929-31 [12024158.001]
  • [Cites] Surgery. 2002 Jun;131(6):687-8 [12075187.001]
  • [Cites] Curr Surg. 2003 May-Jun;60(3):313-4 [14972264.001]
  • [Cites] Int Surg. 1971 Aug;56(2):113-7 [5560000.001]
  • [Cites] Dis Colon Rectum. 1972 Nov-Dec;15(6):441-4 [4645612.001]
  • [Cites] Gastrointest Endosc. 1975 Nov;22(2):90-1 [1193347.001]
  • [Cites] AJR Am J Roentgenol. 1979 Oct;133(4):743-5 [114027.001]
  • [Cites] Radiology. 1982 Feb;142(2):409-14 [7054830.001]
  • [Cites] Gastrointest Endosc. 1982 Aug;28(3):186-8 [7129044.001]
  • [Cites] Arch Surg. 1983 Sep;118(9):1081-3 [6615219.001]
  • [Cites] South Med J. 1987 Sep;80(9):1176-9 [3629321.001]
  • [Cites] Dis Colon Rectum. 1987 Nov;30(11):888-93 [3677966.001]
  • [Cites] Surgery. 1991 Sep;110(3):570-2 [1887386.001]
  • [Cites] Dis Colon Rectum. 1991 Nov;34(11):1027-9 [1834446.001]
  • [Cites] Eur J Surg. 1996 Nov;162(11):915-9 [8956963.001]
  • [Cites] Aust N Z J Surg. 1998 Feb;68(2):133-5 [9494006.001]
  • [Cites] Int J Colorectal Dis. 1998;13(1):1-2 [9548092.001]
  • [Cites] Surgery. 1963 May;53:598-603 [13934160.001]
  • [Cites] Am Surg. 2001 May;67(5):491-4 [11379657.001]
  • (PMID = 16121884.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 22
  • [Other-IDs] NLM/ PMC3015622
  •  go-up   go-down


56. Gupta S: Colorectal polyps: the scope and management of the problem. Am J Med Sci; 2008 Nov;336(5):407-17
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colorectal polyps: the scope and management of the problem.
  • Much of the benefit of colorectal cancer screening has been attributed to detection and removal of adenomatous polyps, highlighting the importance of colorectal polyps as targets for intervention and as biomarkers for colorectal cancer risk.
  • This review details the epidemiology of sporadic colorectal polyps, rationale behind use of polyps as an important surrogate for colorectal cancer risk, the benefits and limitations of secondary prevention of colorectal polyps through chemopreventive and dietary interventions, as well as colon surveillance.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonic Polyps / surgery. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / prevention & control
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / epidemiology. Adenoma / pathology. Adenoma / prevention & control. Congresses as Topic. Cyclooxygenase Inhibitors / therapeutic use. Diet. Humans. Mass Screening. Middle Aged. Risk Factors. Sigmoidoscopy

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19011398.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1 KL2 RR024983-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors
  •  go-up   go-down


57. Kahi CJ, Rex DK: Screening and surveillance of colorectal cancer. Gastrointest Endosc Clin N Am; 2005 Jul;15(3):533-47, ix
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colonoscopy allows effective detection and removal of precursor adenomatous polyps and is the dominant CRC screening modality.

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15990056.001).
  • [ISSN] 1052-5157
  • [Journal-full-title] Gastrointestinal endoscopy clinics of North America
  • [ISO-abbreviation] Gastrointest. Endosc. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 120
  •  go-up   go-down


58. Cabrera CM, López-Nevot MA: APC and chromosome instability in colorectal cancer. Rev Esp Enferm Dig; 2005 Oct;97(10):738-43
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colon cancer is a common disease that can be sporadic or familial.
  • An inactivated adenomatous polyposis coli (APC) suppressor gene is found in over 80% of colorectal tumors, this being an early alteration in the development of adenomatous polyps.
  • APC function is not only critical for tumor initiation and progression, and chromosome instability (CIN) is another characteristic dependent at least partly on APC mutations.

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Rev Esp Enferm Dig. 2005 Oct;97(10):683-7 [16351460.001]
  • (PMID = 16351465.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


59. Glazer E, Golla V, Forman R, Zhu H, Levi G, Bodenheimer HC Jr: Serrated adenoma is a risk factor for subsequent adenomatous polyps. Dig Dis Sci; 2008 Aug;53(8):2204-7
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serrated adenoma is a risk factor for subsequent adenomatous polyps.
  • BACKGROUND: Serrated adenomas (SA) are histologically defined by the presence of both hyperplastic and adenomatous features.
  • These uncommon polyps are thought to play an important role in the development of sporadic colorectal cancers (CRC) with microsatellite instability (MSI).
  • There is paucity of data on the risk of progression of SA to CRC.
  • This study was undertaken to define the relationship between SA and the future development of adenomatous polyps.
  • METHODS: Colonoscopic biopsies that contained a pathologic diagnosis of SA were identified from a pathology database of a major urban academic medical center.
  • These were matched to controls by age, sex, indication for colonoscopy, polyp type and number and duration of follow-up.
  • Of these, 80 patients (0.5%) with SA were found, and of these SA, 80% were found in the left colon.
  • The average age of patients undergoing colonoscopy was 58.5 years, and the average age of patients with SA was 68 years (P = 0.004).
  • Of all patients with SA, 7 (9%) had concomitant CRC.
  • On follow-up examination four patients (24%) and no controls had adenomatous polyps (P = 0.01).
  • CONCLUSIONS: While SA are uncommon, they are commonly associated with colorectal cancer.
  • This study found a significant association between SA and the subsequent development of adenomatous polyps.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Aged. Case-Control Studies. Colonoscopy. Disease Progression. Female. Humans. Hyperplasia. Male. Middle Aged. Retrospective Studies. Risk Factors

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18320324.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


60. Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels AB: Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology; 2008 Feb;134(2):388-95
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cigarette smoking and adenomatous polyps: a meta-analysis.
  • BACKGROUND & AIMS: Through the past 2 decades, a consistent association between cigarette smoking and colorectal adenomatous polyps, recognized precursor lesions of colorectal cancer, has been shown.
  • We performed a meta-analysis to provide a quantitative pooled risk estimate of the association, focusing on the different characteristics of the study populations, study designs, and clinical feature of the polyps.
  • CONCLUSIONS: This meta-analysis provides strong evidence of the detrimental effect of cigarette smoking on the development of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colorectal Neoplasms / epidemiology. Smoking / adverse effects


61. Oset P, Jasińska A, Szcześniak P, Orszulak-Michalak D, Talar-Wojnarowska R, Małecka-Panas E: [Analysis of serum gastrin levels in patients with adenomatous polyps of the colon]. Pol Merkur Lekarski; 2009 May;26(155):458-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of serum gastrin levels in patients with adenomatous polyps of the colon].
  • Adenomatous polyps are known risk factor of colon cancer.
  • Gastrin is a peptide hormone involved in the growth of both normal and malignant intestinal tissue, which probably may promote progression through the adenoma-carcinoma sequence.
  • MATERIAL AND METHODS: The study included 60 patients with adenomatous polyps of the colon and 30 healthy volunteers.
  • There was no association between gastrin levels and size, number, localisation and histologic type of polyps (p > 0.05).
  • CONCLUSION: Despite of elevated serum levels in patients with colonic adenomas we did not observe the association between gastrin levels and size, grade of dysplasia and histologic type of polyps.
  • [MeSH-major] Adenomatous Polyps / blood. Gastrins / blood

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19606697.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Gastrins
  •  go-up   go-down


62. Heiken JP: CT colonography screening: ready for prime time? Cancer Imaging; 2009;9 Spec No A:S59-62
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although multiple prospective randomized trials and observational studies have demonstrated that mortality from colon cancer can be reduced with screening and removal of adenomatous polyps, compliance with screening guidelines remains low.
  • Recent CT colonography (CTC) trials have shown that CTC is capable of demonstrating adenomatous polyps > or =10 mm (and in most cases > or = 6 mm) with sensitivities comparable to those for optical colonoscopy.
  • [MeSH-major] Adenocarcinoma / radiography. Adenoma / radiography. Colonic Neoplasms / radiography. Colonic Polyps / radiography. Colonography, Computed Tomographic
  • [MeSH-minor] Adenomatous Polyps / radiography. Aged. Colonoscopy / adverse effects. Expert Testimony. Humans. Insurance Coverage. Mass Screening. Medicaid. Medicare. Middle Aged. Multicenter Studies as Topic. Patient Compliance. Practice Guidelines as Topic. Randomized Controlled Trials as Topic / statistics & numerical data. Sensitivity and Specificity. United States

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] N Engl J Med. 2000 Nov 30;343(22):1603-7 [11096167.001]
  • [Cites] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385.001]
  • [Cites] Am J Gastroenterol. 2002 Jun;97(6):1296-308 [12094842.001]
  • [Cites] J Natl Cancer Inst. 2003 Feb 5;95(3):230-6 [12569145.001]
  • [Cites] Gastroenterology. 2003 Apr;124(4):911-6 [12671887.001]
  • [Cites] Eur Radiol. 2003 Jun;13(6):1297-302 [12764645.001]
  • [Cites] N Engl J Med. 2003 Dec 4;349(23):2191-200 [14657426.001]
  • [Cites] JAMA. 2004 Apr 14;291(14):1713-9 [15082698.001]
  • [Cites] Cancer. 2004 May 15;100(10):2093-103 [15139050.001]
  • [Cites] Radiology. 2004 Aug;232(2):611-20 [15215541.001]
  • [Cites] N Engl J Med. 1992 Mar 5;326(10):653-7 [1736103.001]
  • [Cites] Lancet. 1996 Nov 30;348(9040):1467-71 [8942774.001]
  • [Cites] Lancet. 1996 Nov 30;348(9040):1472-7 [8942775.001]
  • [Cites] Am J Med. 1999 Jan 25;106(1A):7S-10S [10089107.001]
  • [Cites] Lancet. 2005 Jan 22-28;365(9456):305-11 [15664225.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):409-16 [15734966.001]
  • [Cites] Radiology. 2005 Aug;236(2):519-26 [16040909.001]
  • [Cites] Am J Gastroenterol. 2005 Dec;100(12):2771-6 [16393234.001]
  • [Cites] AJR Am J Roentgenol. 2006 Mar;186(3):718-28 [16498099.001]
  • [Cites] Clin Gastroenterol Hepatol. 2006 Mar;4(3):343-8 [16527698.001]
  • [Cites] Radiology. 2006 May;239(2):457-63 [16543590.001]
  • [Cites] Radiology. 2006 May;239(2):464-71 [16569789.001]
  • [Cites] Radiology. 2006 May;239(2):313-6 [16641348.001]
  • [Cites] Cancer. 2007 Jun 1;109(11):2213-21 [17455218.001]
  • [Cites] N Engl J Med. 2007 Oct 4;357(14):1403-12 [17914041.001]
  • [Cites] AJR Am J Roentgenol. 2008 Jan;190(1):136-44 [18094303.001]
  • [Cites] Gastroenterology. 2008 May;134(5):1570-95 [18384785.001]
  • [Cites] Radiology. 2008 Oct;249(1):151-9 [18796673.001]
  • [Cites] N Engl J Med. 2008 Sep 18;359(12):1207-17 [18799557.001]
  • [Cites] Gastroenterology. 2008 Oct;135(4):1100-5 [18691580.001]
  • [Cites] Ann Intern Med. 2008 Nov 4;149(9):627-37 [18838716.001]
  • [Cites] Gut. 2009 Feb;58(2):241-8 [18852257.001]
  • [Cites] Radiology. 2000 May;215(2):353-7 [10796907.001]
  • [Cites] Gastroenterology. 2009 Mar;136(3):1121-2; author reply 122-3 [19167389.001]
  • [Cites] Am J Gastroenterol. 2009 Mar;104(3):739-50 [19240699.001]
  • [Cites] Am J Prev Med. 2009 Jul;37(1):8-16 [19442479.001]
  • [Cites] JAMA. 2009 Jun 17;301(23):2453-61 [19531785.001]
  • [Cites] Radiology. 2002 Jul;224(1):25-33 [12091658.001]
  • (PMID = 19965295.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Lectures
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2797457
  •  go-up   go-down


63. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of mtDNA sequence variants in colorectal adenomatous polyps.
  • Colorectal tumors mostly arise from sporadic adenomatous polyps.
  • Polyps are defined as a mass of cells that protrudes into the lumen of the colon.
  • Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia.
  • It has been shown that polyps were benign tumors which may undergo malignant transformation.
  • Adenomatous polyps have been classified into three histologic types; tubular, tubulovillous, and villous with increasing malignant potential.
  • The ability to differentially diagnose these colorectal adenomatous polyps is important for therapeutic intervention.
  • To date, little efforts have been directed to identifying genetic changes involved in adenomatous polyps.
  • This study was designed to examine the relevance of mitochondrial genome alterations in the three adenomatous polyps.
  • Using high resolution restriction endonucleases and PCR-based sequencing, fifty-seven primary fresh frozen tissues of adenomatous polyps (37 tumors and 20 matched surrounding normal tissues) obtained from the southern regional Cooperative Human Tissue Network (CHTN) and Grady Memorial Hospital at Atlanta were screened with three mtDNA regional primer pairs that spanned 5.9 kbp.
  • Notably, a heteroplasmic variant C8515G/T in the MT-ATP 8 gene and a germline variant 8327delA in the tRNAlys was observed in all the tissue samples of the three adenomatous polyps in comparison to the referenced database sequence.
  • Our current data provide a basis for continued investigation of certain mtDNA variants as predictors of the three adenomatous polyps in a larger number of clinicopathological specimens.
  • [MeSH-major] Adenomatous Polyps / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Mitochondrial / analysis. Genetic Variation
  • [MeSH-minor] Aged. Biopsy. DNA Mutational Analysis. Databases, Genetic. Disease Progression. Humans. Middle Aged. Polymerase Chain Reaction. Prognosis

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Surg Pathol. 2004 Nov;28(11):1460-5 [15489649.001]
  • [Cites] Science. 1987 Oct 9;238(4824):193-7 [2889267.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Gastroenterology. 1990 Feb;98(2):371-9 [2403953.001]
  • [Cites] Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11164-8 [1454794.001]
  • [Cites] FEBS Lett. 1995 Jan 16;358(1):1-3 [7821417.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9 [9012815.001]
  • [Cites] Mol Cancer. 2004 Oct 13;3:30 [15482594.001]
  • [Cites] Cancer Res. 2005 Mar 1;65(5):1655-63 [15753359.001]
  • [Cites] Br J Cancer. 2005 Aug 8;93(3):331-7 [15956973.001]
  • [Cites] Science. 2008 May 2;320(5876):661-4 [18388260.001]
  • [Cites] Diagn Mol Pathol. 2008 Jun;17(2):94-100 [18382370.001]
  • [Cites] Carcinogenesis. 2010 Feb;31(2):296-301 [19945968.001]
  • [Cites] Hum Pathol. 2002 Mar;33(3):372-5 [11979380.001]
  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
  •  go-up   go-down


64. Kandiah M, Ramadas A, Shariff ZM, Yusof RM, Gul YG: Diet and lifestyle intervention among patients with colorectal adenomas: rationale and design of a Malaysian study. Asian Pac J Cancer Prev; 2005 Oct-Dec;6(4):553-60
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The primary aim of this trial is to evaluate the effectiveness of the intervention with reference to recurrence of adenomatous polyps over a two year period--the first year being the intervention period and the second year of the study allowing for post-intervention follow-up.
  • One hundred and sixteen patients who were diagnosed with colorectal adenomatous polyps in the previous twelve months at the Hospital Kuala Lumpur have already been enrolled in this trial.
  • [MeSH-major] Adenoma / diet therapy. Colorectal Neoplasms / diet therapy. Life Style

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16436011.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
  •  go-up   go-down


65. Su YH, Wang M, Aiamkitsumrit B, Brenner DE, Block TM: Detection of a K-ras mutation in urine of patients with colorectal cancer. Cancer Biomark; 2005;1(2-3):177-82
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We further compared, in a blinded study, the frequency of detecting mutated K-ras sequence in DNA isolated from plasma and urine derived from individuals who have either a colorectal carcinoma (CRC), or adenomatous polyps that contain a mutation in codon 12 of the K-ras proto-oncogene.
  • There was an 83% concurrence of mutated DNA detected in urine and its corresponding disease tissue from the same individuals, when paired urine and tissue sections from 20 patients with either CRC or adenomatous polyps were analyzed for K-ras mutation.
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / urine. DNA / classification. DNA / urine. Humans. Mutation. Nucleic Acid Denaturation. Peptide Nucleic Acids. Polymerase Chain Reaction / methods

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17192038.001).
  • [ISSN] 1574-0153
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA86400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Peptide Nucleic Acids; 9007-49-2 / DNA; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Number-of-references] 19
  •  go-up   go-down


66. Mathew J, Saklani AK, Borghol M: Surveillance colonoscopy in patients with colorectal cancer: how often should we be doing it? Surgeon; 2006 Feb;4(1):3-5, 62
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The optimum protocol for colonoscopic surveillance following curative resection for colorectal cancer has not been established.
  • The variables studied included the tumour site, Duke's stage, number of recurrences, number of metachronous tumours, size and number of polyps and their biopsy results.
  • Adenomatous polyps were identified in 24 patients of which nine had multiple/advanced adenomas (equal to or more than 1cm adenomatous polyps, or with severe dysplasia).
  • [MeSH-major] Adenoma / surgery. Colonoscopy / statistics & numerical data. Colorectal Neoplasms / surgery. Neoplasm Recurrence, Local / diagnosis

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Surgeon. 2007 Apr;5(2):125 [17455380.001]
  • (PMID = 16459492.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
  •  go-up   go-down


67. Otani K, Kitayama J, Yasuda K, Nio Y, Iwabu M, Okudaira S, Aoki J, Yamauchi T, Kadowaki T, Nagawa H: Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice. Cancer Lett; 2010 Feb 28;288(2):177-82
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In order to clarify the role of adiponectin in colorectal carcinogenesis, we examined the effect of exogenous administration of adiponectin on intestinal polyp formation in C57BL/6J-Apc(Min)(/+) mice, which possess a point mutation in the Apc gene.
  • And we found that adiponectin treatment significantly decreased the number of adenomatous polyps, especially polyps larger than 2mm in diameter, in the small intestine.
  • Two major receptors for adiponectin, AdipoR1 and AdipoR2, were expressed in adenomatous polyps, and their expression levels were not altered by adiponectin injection.
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Genes, APC. Point Mutation

  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19646806.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Adipoq protein, mouse; 0 / RNA, Messenger; 0 / Receptors, Adiponectin; 0 / Recombinant Proteins; 0 / adiponectin receptor 1, mouse; 0 / adiponectin receptor 2, mouse
  •  go-up   go-down


68. Valantas MR, Farmer WM, DiPalma JA: Do gastroenterologists notify polyp patients that family members should have screening? South Med J; 2005 Feb;98(2):162-3
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do gastroenterologists notify polyp patients that family members should have screening?
  • OBJECTIVE: The objective of this study was to determine whether patients found to have adenomatous polyps or cancer were notified that their relatives should have screening, due to an increased risk of developing colorectal cancer.
  • METHODS: Consecutive (n = 121) colonoscopy patients from December of 1999 to October of 2001 found to have adenomatous colon polyps or colon cancer formed the study group.
  • Charts were reviewed for documentation of relative notification, and when documentation was not present, study subjects were contacted by telephone.
  • Adenomatous polyps were seen in 95%, and cancer seen in 5%.
  • Overall, 30% of the patients were notified: 23 of 82 (28%) in the polyp group and 3 of 4 (75%) in the cancer group.
  • Template notification letters may complement the polyp surveillance programs that many colonoscopists use.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Intestinal Polyps / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15759945.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


69. Kim DH, Lee SY, Choi KS, Lee HJ, Park SC, Kim J, Han CJ, Kim YC: The usefulness of colonoscopy as a screening test for detecting colorectal polyps. Hepatogastroenterology; 2007 Dec;54(80):2240-2
MedlinePlus Health Information. consumer health - Rectal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The usefulness of colonoscopy as a screening test for detecting colorectal polyps.
  • BACKGROUND/AIMS: Colonic polyps are the most common lesions encountered during screening colonoscopy.
  • The purpose of this study is to evaluate the usefulness of colonoscopy to detect colonic polyps in adults.
  • RESULTS: Complete colonic evaluation was possible in 4,491 (97.0%) subjects, and 804 (17.9%) had adenomatous polyps, including 153 subjects (3.4%) with advanced adenomas.
  • There was a trend toward an increased prevalence of adenomatous polyps with age.
  • Among the subjects with polyps, 72.1% of the subjects had distal polyps and the relative risk for proximal polyp, according to the distal findings, was 5.4 (95% CI: 4.5-6.3) for adenomatous polyp, 5.1 (95% CI 3.6-7.0) for advanced adenoma as compared to the finding of no adenomatous polyp.
  • CONCLUSIONS: Colonoscopy performed by experienced colonoscopists as a screening test is feasible for detecting subjects with colorectal polyps.
  • [MeSH-major] Colonoscopy. Intestinal Polyps / diagnosis. Rectal Diseases / diagnosis
  • [MeSH-minor] Adult. Age Distribution. Aged. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Female. Humans. Male. Mass Screening / methods. Middle Aged. Prevalence. Sex Distribution

  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18265641.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


70. Kenney BC, Jain D: Identification of lymphatics within the colonic lamina propria in inflammation and neoplasia using the monoclonal antibody D2-40. Yale J Biol Med; 2008 Sep;81(3):103-13
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DESIGN: Representative sections of normal colon, inflamed colon, hyperplastic polyps, inflammatory polyps, adenomatous polyps, adenomatous polyps containing intramucosal carcinoma, and invasive colonic adenocarcinomas were subjected to immunohistochemical staining with D2-40.
  • RESULTS: Lymphatics were not identified within the lamina propria of normal colon.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Gastroenterology. 1973 Jan;64(1):51-66 [4683855.001]
  • [Cites] Gastroenterology. 1966 Dec;51(6):994-1003 [5958610.001]
  • [Cites] Aust N Z J Surg. 1981 Oct;51(5):429-33 [6947780.001]
  • [Cites] Br J Surg. 1985 Sep;72(9):698-702 [4041728.001]
  • [Cites] Lancet. 1986 Oct 18;2(8512):904-7 [2876336.001]
  • [Cites] N Engl J Med. 1991 Jan 3;324(1):1-8 [1701519.001]
  • [Cites] J Natl Cancer Inst. 1992 Dec 16;84(24):1875-87 [1281237.001]
  • [Cites] Cancer. 1994 Nov 1;74(9):2430-5 [7922996.001]
  • [Cites] J Submicrosc Cytol Pathol. 1998 Oct;30(4):545-53 [9851063.001]
  • [Cites] Am J Pathol. 1999 Feb;154(2):385-94 [10027397.001]
  • [Cites] Br J Cancer. 1958 Sep;12(3):309-20 [13596482.001]
  • [Cites] Breast Cancer Res Treat. 2005 May;91(2):125-32 [15868440.001]
  • [Cites] J Pathol. 2005 Jun;206(2):170-7 [15846845.001]
  • [Cites] Hepatogastroenterology. 2005 Jul-Aug;52(64):1057-61 [16001629.001]
  • [Cites] Mod Pathol. 2006 Oct;19(10):1317-23 [16799477.001]
  • [Cites] Eur Surg Res. 2006;38(5):438-44 [16912482.001]
  • [Cites] Dis Colon Rectum. 2007 Jan;50(1):13-21 [17115337.001]
  • [Cites] Dis Colon Rectum. 2007 Mar;50(3):308-14 [17164964.001]
  • [Cites] Clin Cancer Res. 2003 Jan;9(1):250-6 [12538477.001]
  • [Cites] Cancer Res. 2003 Apr 15;63(8):1920-6 [12702584.001]
  • [Cites] Am J Pathol. 2003 Jun;162(6):1951-60 [12759251.001]
  • [Cites] Lymphology. 2003 Jun;36(2):52-61 [12926829.001]
  • [Cites] Oncol Rep. 2004 Jan;11(1):47-50 [14654901.001]
  • [Cites] World J Gastroenterol. 2004 Nov 15;10(22):3261-3 [15484296.001]
  • [Cites] Cancer. 1981 Mar 15;47(6):1424-9 [7226068.001]
  • (PMID = 18827885.001).
  • [ISSN] 1551-4056
  • [Journal-full-title] The Yale journal of biology and medicine
  • [ISO-abbreviation] Yale J Biol Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
  • [Other-IDs] NLM/ PMC2553648
  •  go-up   go-down


71. Gheorghe C, Iacob R, Gheorghe L, Cotruta B, Bancila I, Iacob S, Bucur D, Voinea D, Popescu I: Projected dynamics of colonoscopic screening and surveillance for colorectal cancer. Hepatogastroenterology; 2008 Sep-Oct;55(86-87):1568-72
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Three hundred and thirty-eight patients (72.5%) were included in the registry for colonoscopic surveillance after a curative resection for colorectal cancer, 101 patients (21.7%) for follow-up after endoscopic polypectomies of adenomatous polyps, 21 patients (4.5%) for long lasting inflammatory bowel disease (IBD), and 2 patients (0.4%) for familial adenomatous polyposis.
  • The projected dynamics and costs of colonoscopies scheduled for one year in our center indicate 11650 Euro/9.4 months spending for all procedures, 8450 Euro/8.8 months for surveillance after curative resection for CRC, 2525 Euro/24.9 months for surveillance after endoscopic polypectomies of adenomatous polyps and 525 Euro/6.8 months for screening for CRC in patients with long history of IBD, respectively.

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19102344.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


72. Apel D, Jakobs R, Schilling D, Weickert U, Teichmann J, Bohrer MH, Riemann JF: Accuracy of high-resolution chromoendoscopy in prediction of histologic findings in diminutive lesions of the rectosigmoid. Gastrointest Endosc; 2006 May;63(6):824-8
Hazardous Substances Data Bank. Indigotindisulfonate sodium .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The ability to differentiate adenomatous from nonadenomatous colonic polyps by using chromoendoscopy would obviate the need to remove hyperplastic lesions.
  • The aim of this study was to define the accuracy of high-resolution chromoendoscopy for the determination of colonic polyp histology.
  • METHODS: In 158 patients, 273 polyps (<5 mm) in the rectosigmoid were estimated for their histology.
  • RESULTS: The resected polyps included 48 adenomatous and 225 nonadenomatous polyps.
  • When histologically confirmed hyperplastic polyps were compared with adenomatous polyps, the prediction of hyperplastic polyps based on endoscopic findings had a sensitivity of 93%, a specificity of 60%, and an overall accuracy of 81%.
  • CONCLUSIONS: The results suggest that the chromoendoscopy only marginally improves the determination between hyperplastic and adenomatous polyps when using high-resolution colonoscopes.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Endoscopy, Gastrointestinal / methods. Sigmoid Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • Hazardous Substances Data Bank. INDIGO .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Gastrointest Endosc. 2006 May;63(6):829-30 [16650547.001]
  • (PMID = 16650546.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; D3741U8K7L / Indigo Carmine
  •  go-up   go-down


73. Cheah PY, Wong YH, Chau YP, Loi C, Lim KH, Lim JF, Koh PK, Eu KW: Germline bone morphogenesis protein receptor 1A mutation causes colorectal tumorigenesis in hereditary mixed polyposis syndrome. Am J Gastroenterol; 2009 Dec;104(12):3027-33
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: Hereditary mixed polyposis syndrome (HMPS) is characterized by polyps of mixed adenomatous/hyperplastic/atypical juvenile histology that are autosomal dominantly inherited and that eventually lead to colorectal cancer (CRC).
  • Although CRC with adenomatous polyps is initiated by inactivating adenomatous polyposis coli (APC), the initiating event of CRC with mixed polyps remains unclear.
  • In two families, it is shown to co-segregate with the disease phenotype in all affected members over three generations, indicating that it is the disease-causing mutation.
  • The most defining characteristic is the presence of mixed hyperplastic-adenomatous polyps.
  • Juvenile polyps are rarely reported, and if present, are usually of mixed components.
  • Detailed histology of the polyps from one patient over 11 years distinguishes HMPS from juvenile polyposis syndrome (JPS).
  • CONCLUSIONS: Germline BMPR1A defect is the disease-causing mutation in 50% of the HMPS families.
  • If patients present with mixed morphology polyps in the large bowel that are autosomal dominantly inherited and corresponding absence of upper gastrointestinal abnormalities, the gene to begin mutation screening should be BMPR1A rather than APC.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Bone Morphogenetic Protein Receptors, Type I / genetics. Colorectal Neoplasms / genetics. Germ-Line Mutation

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19773747.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / SMAD4 protein, human; 0 / Smad4 Protein; EC 2.7.11.30 / BMPR1A protein, human; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  •  go-up   go-down


74. Bigler J, Ulrich CM, Kawashima T, Whitton J, Potter JD: DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps. Cancer Epidemiol Biomarkers Prev; 2005 Nov;14(11 Pt 1):2501-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA repair polymorphisms and risk of colorectal adenomatous or hyperplastic polyps.
  • In a Minnesota-based case-control study of cases with only adenomatous polyps (n = 384), only hyperplastic polyps (n = 191), or both types of polyps (n = 119) versus polyp-free controls (n = 601), we investigated the role of polymorphisms in the DNA repair genes O(6)-methylguanine methyltransferase (MGMT; p.L84F and p.I143V), XPD (p.D312N and p.K751Q), and XPG (p.D1104H).
  • MGMT polymorphisms were not associated with polyp risk.
  • Overall, a homozygous variant XPD-combined genotype was associated with an increased risk of adenomatous polyps [odds ratio (OR), 1.57; 95% confidence interval (95% CI), 1.04-2.38] and an XPGHH1104 genotype with a decreased risk of hyperplastic polyps (OR, 0.36; 95% CI, 0.13-0.98).
  • Smokers did not have a significantly increased risk of adenomatous polyps in the absence of synchronous hyperplastic polyps, except for subjects with a homozygous variant XPD genotype or a homozygous wild-type XPG genotype (OR, 3.93; 95% CI, 1.68-9.21 and OR, 1.59; 95% CI, 1.01-2.50, respectively).
  • Smoking was associated with a statistically significant 2.5- to 6-fold increased risk of hyperplastic polyps for individuals with most of the DNA repair genotypes.

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16284370.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA074794; United States / NCI NIH HHS / CA / R01 CA 59045
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase; EC 3.6.4.12 / Xeroderma Pigmentosum Group D Protein; EC 5.99.- / ERCC2 protein, human
  •  go-up   go-down


75. Ji JH, Park BJ, Park YS, Hwang JH, Chung SH, Kim N, Lee DH, Jung HC, Song IS: [Clinicopathologic study of colorectal polyps and obesity in Korean adult]. Korean J Gastroenterol; 2007 Jan;49(1):10-6
MedlinePlus Health Information. consumer health - Obesity.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic study of colorectal polyps and obesity in Korean adult].
  • Numerous epidemiologic studies have shown a positive association between obesity and colorectal polyps.
  • There are few studies investigating the association between colorectal adenomatous polyps and body fat composition in Korea.
  • We tried to examine the relationship between body fatness and colorectal adenomatous polyps in health check-up subjects in Korea.
  • We tried to reveal the relationship between body mass index (BMI) and size, location, number and histopathological type of polyps.
  • RESULTS: The mean value of BMI in total polyp-free group (23.8+/-2.9) was not different from that of the polyp group (24.5+/-2.8, p=0.09).
  • The frequency of rectosigmoid polyps in obese patients (20.4%) was higher than that in non-obese patients (16.0%, p<0.05).
  • The frequency of adenomatous polyp was not different between obese and non-obese group.
  • Number of polyps (> or=4) correlated well with obesity.
  • Moreover, age and triglyceride level in patients with colonic adenoma were significantly higher than in patients without colonic adenom.
  • CONCLUSIONS: This study shows that obesity is not associated with colonic adenomatous polyp in Korean population.
  • However, we observed that obesity may be associated with rectosigmoid colon polyps.
  • Furthermore, age and triglyceride level might be the risk factors of colonic adenomatous polyps in Korean population.
  • [MeSH-major] Adenomatous Polyps / complications. Colonic Neoplasms / complications. Obesity / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Body Mass Index. Colonic Polyps / complications. Colonic Polyps / epidemiology. Colonic Polyps / pathology. Comorbidity. Female. Humans. Korea. Male. Middle Aged. Retrospective Studies. Sigmoidoscopy

  • Genetic Alliance. consumer health - Obesity.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18167428.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  •  go-up   go-down


76. Jo WS, Bandipalliam P, Shannon KM, Niendorf KB, Chan-Smutko G, Hur C, Syngal S, Chung DC: Correlation of polyp number and family history of colon cancer with germline MYH mutations. Clin Gastroenterol Hepatol; 2005 Oct;3(10):1022-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of polyp number and family history of colon cancer with germline MYH mutations.
  • BACKGROUND & AIMS: Affected individuals with biallelic MYH mutations are believed to display multiple adenomatous polyps without evidence of vertical transmission.
  • Our goal was to determine the detection rate of germline MYH mutations in a high-risk gastrointestinal cancer clinic population by using polyp number as a selection criterion.
  • RESULTS: Among 45 patients with more than 15 adenomatous polyps not diagnosed with familial adenomatous polyposis, 7 (15.6%) had biallelic MYH mutations.
  • When 122 participants from a high-risk gastrointestinal cancer clinic who did not fulfill these criteria were tested, 2 additional patients with biallelic mutations were identified.
  • Both had young-onset colorectal cancer (age, <50 y) with fewer than 15 polyps.
  • CONCLUSIONS: Most individuals with MYH mutations exhibit multiple adenomatous polyps.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16234049.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  •  go-up   go-down


77. Cappell MS: Pathophysiology, clinical presentation, and management of colon cancer. Gastroenterol Clin North Am; 2008 Mar;37(1):1-24, v
MedlinePlus Health Information. consumer health - Colonoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colon cancer is believed to arise from two types of precursor polyps via two distinct pathways: conventional adenomas by the conventional adenoma-to-carcinoma sequence and serrated adenomas according to the serrated adenoma-to-carcinoma theory.
  • Advanced colon cancer often presents with symptoms, but early colon cancer and premalignant adenomatous polyps commonly are asymptomatic, rendering them difficult to detect and providing the rationale for mass screening of adults over age 50.
  • [MeSH-major] Biomarkers, Tumor / genetics. Colonic Neoplasms. Colonoscopy / methods. DNA, Neoplasm / analysis. Genetic Predisposition to Disease

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18313537.001).
  • [ISSN] 0889-8553
  • [Journal-full-title] Gastroenterology clinics of North America
  • [ISO-abbreviation] Gastroenterol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Genetic Markers
  • [Number-of-references] 113
  •  go-up   go-down


78. Groblewska M, Mroczko B, Szmitkowski M: [The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer development]. Postepy Hig Med Dosw (Online); 2010 Jan 26;64:22-30
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The development of this tumor is a complex, long-term, and multi-step process, from small dysplastic lesions of normal colorectal mucosa, through adenomatous polyps, to carcinoma in situ.

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20173217.001).
  • [ISSN] 1732-2693
  • [Journal-full-title] Postepy higieny i medycyny doswiadczalnej (Online)
  • [ISO-abbreviation] Postepy Hig Med Dosw (Online)
  • [Language] POL
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Number-of-references] 61
  •  go-up   go-down


79. Ayoub J, Granado B, Mhanna Y, Romain O: SVM based colon polyps classifier in a wireless active stereo endoscope. Conf Proc IEEE Eng Med Biol Soc; 2010;2010:5585-8
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SVM based colon polyps classifier in a wireless active stereo endoscope.
  • This work focuses on the recognition of three-dimensional colon polyps captured by an active stereo vision sensor.
  • The study is related to Cyclope, this prototype sensor allows real time 3D object reconstruction and continues to be optimized technically to improve its classification task by differentiation between hyperplastic and adenomatous polyps.
  • Inspired by intensity histogram, the work shows a new approach that extracts a set of features based on depth histogram and combines stereo measurement with SVM classifiers to correctly classify benign and malignant polyps.
  • [MeSH-major] Algorithms. Colonic Polyps / classification. Endoscopes. Wireless Technology / instrumentation

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21096484.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


80. De Palma GD, Rega M, Masone S, Persico M, Siciliano S, Addeo P, Persico G: Conventional colonoscopy and magnified chromoendoscopy for the endoscopic histological prediction of diminutive colorectal polyps: a single operator study. World J Gastroenterol; 2006 Apr 21;12(15):2402-5
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conventional colonoscopy and magnified chromoendoscopy for the endoscopic histological prediction of diminutive colorectal polyps: a single operator study.
  • AIM: To accurately differentiate the adenomatous from the non-adenomatous polyps by colonoscopy.
  • All polyps were completely removed endoscopically for histological evaluation.
  • RESULTS: A total of 240 lesions were identified, of which 158 (65.8%) were non-neoplastic and 82 (34.2%) were adenomatous.
  • [MeSH-major] Colonoscopy. Endoscopy, Gastrointestinal / methods. Intestinal Polyps / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adult. Aged. Aged, 80 and over. Colonic Polyps / diagnosis. Female. Humans. Male. Middle Aged

  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Surg Endosc. 1994 Jun;8(6):672-6 [8059305.001]
  • [Cites] Gastroenterologist. 1993 Jun;1(2):158-64 [8049888.001]
  • [Cites] Gastroenterology. 1996 Apr;110(4):1253-8 [8613016.001]
  • [Cites] Gastrointest Endosc. 1996 Jul;44(1):8-14 [8836710.001]
  • [Cites] Endoscopy. 2001 Apr;33(4):306-10 [11315890.001]
  • [Cites] Gastrointest Endosc. 2002 May;55(6):687-94 [11979251.001]
  • [Cites] Gastrointest Endosc. 2003 Jan;57(1):48-53 [12518130.001]
  • [Cites] Gastrointest Endosc. 2003 Dec;58(6 Suppl):S3-43 [14652541.001]
  • [Cites] Gastrointest Endosc. 1982 Feb;28(1):1-5 [7056447.001]
  • [Cites] Am J Gastroenterol. 1988 Feb;83(2):120-2 [3341333.001]
  • [Cites] Gastrointest Endosc. 1988 Jan-Feb;34(1):32-7 [3258260.001]
  • [Cites] Dig Dis Sci. 1988 Sep;33(9):1175-7 [3044716.001]
  • [Cites] Dis Colon Rectum. 1992 Feb;35(2):178-81 [1735321.001]
  • [Cites] Cancer. 1992 Sep 1;70(5 Suppl):1236-45 [1511370.001]
  • [Cites] Am J Gastroenterol. 1995 Jan;90(1):24-8 [7801943.001]
  • (PMID = 16688833.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4088078
  •  go-up   go-down


81. Beaton MD, Taylor B, Driman D, Ainsworth P, Adams PC: Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation? Can J Gastroenterol; 2008 Jul;22(7):634-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation?
  • Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps.
  • While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colonic Polyps / pathology

  • Genetic Alliance. consumer health - Familial Polyposis.
  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Gut. 1999 Dec;45(6):829-33 [10562580.001]
  • [Cites] Transl Res. 2007 Sep;150(3):147-9 [17761365.001]
  • [Cites] Surg Today. 2001;31(11):1020-3 [11766074.001]
  • [Cites] Dis Colon Rectum. 2002 Jan;45(1):127-34; discussion 134-6 [11786778.001]
  • [Cites] Gut. 2002 May;50(5):636-41 [11950808.001]
  • [Cites] Am J Pathol. 2002 Jun;160(6):2253-7 [12057927.001]
  • [Cites] Am J Gastroenterol. 2002 Jul;97(7):1822-7 [12135043.001]
  • [Cites] J Postgrad Med. 1986 Oct;32(4):206-9 [3585794.001]
  • [Cites] Cancer. 1988 Apr 15;61(8):1563-70 [3349420.001]
  • [Cites] IARC Monogr Eval Carcinog Risks Hum. 1994;61:1-241 [7715068.001]
  • [Cites] Cancer Res. 1997 Mar 1;57(5):812-4 [9041176.001]
  • [Cites] Hum Genet. 1997 Oct;100(5-6):601-5 [9341879.001]
  • [Cites] Am J Hum Genet. 1998 Jun;62(6):1290-301 [9585611.001]
  • [Cites] Nutr Cancer. 1998;31(2):111-8 [9770722.001]
  • [Cites] N Engl J Med. 1999 Mar 18;340(11):825-31 [10080844.001]
  • [Cites] Cancer. 1999 Apr 15;85(8):1664-9 [10223558.001]
  • [Cites] World J Gastroenterol. 2006 Nov 14;12(42):6741-6 [17106919.001]
  • [Cites] Tech Coloproctol. 2006 Dec;10(4):287-96 [17115321.001]
  • [Cites] Crit Rev Oncol Hematol. 2007 Feb;61(2):153-61 [17064931.001]
  • [Cites] Cancer Res. 2001 Mar 15;61(6):2395-8 [11289103.001]
  • (PMID = 18629394.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2661270
  •  go-up   go-down


82. Bresalier RS: Early detection of and screening for colorectal neoplasia. Gut Liver; 2009 Jun;3(2):69-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The long natural history of colorectal neoplasia affords the opportunity to use preventive measures to improve survival in this disease.
  • Currently screening for adenomatous polyps and early-stage cancers is the best methodology for improving survival.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Ann Intern Med. 2009 Jan 6;150(1):1-8 [19075198.001]
  • [Cites] Am J Gastroenterol. 2008 Dec;103(12):3149-51 [18853976.001]
  • [Cites] Ann Intern Med. 2008 Nov 4;149(9):659-69 [18838717.001]
  • [Cites] Ann Intern Med. 2008 Nov 4;149(9):627-37 [18838716.001]
  • [Cites] Clin Gastroenterol Hepatol. 2008 Oct;6(10):1117-21; quiz 1064 [18691942.001]
  • [Cites] Clin Gastroenterol Hepatol. 2008 Oct;6(10):1091-8 [18639495.001]
  • [Cites] Ann Intern Med. 2008 Oct 7;149(7):441-50, W81 [18838724.001]
  • [Cites] N Engl J Med. 2008 Sep 18;359(12):1207-17 [18799557.001]
  • [Cites] Gut. 2008 Aug;57(8):1166-76 [18628378.001]
  • [Cites] CA Cancer J Clin. 2008 May-Jun;58(3):130-60 [18322143.001]
  • [Cites] Ann Intern Med. 2008 Mar 18;148(6):419-26 [18347350.001]
  • [Cites] JAMA. 2008 Mar 5;299(9):1027-35 [18319413.001]
  • [Cites] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387.001]
  • [Cites] Gastroenterology. 2007 Oct;133(4):1077-85 [17698067.001]
  • [Cites] N Engl J Med. 2007 Oct 4;357(14):1403-12 [17914041.001]
  • [Cites] Cochrane Database Syst Rev. 2007;(1):CD001216 [17253456.001]
  • [Cites] Ann Intern Med. 2007 Feb 20;146(4):244-55 [17310048.001]
  • [Cites] Endoscopy. 2007 Feb;39(2):168-73 [17327977.001]
  • [Cites] Gut. 2007 Feb;56(2):210-4 [16891354.001]
  • [Cites] Clin Cancer Res. 2006 Jun 15;12(12):3661-97 [16778094.001]
  • [Cites] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078.001]
  • [Cites] Curr Opin Gastroenterol. 2004 Jan;20(1):32-42 [15703618.001]
  • [Cites] N Engl J Med. 2004 Dec 23;351(26):2704-14 [15616205.001]
  • [Cites] J Natl Cancer Inst. 1999 Mar 3;91(5):434-7 [10070942.001]
  • [Cites] N Engl J Med. 1993 Dec 30;329(27):1977-81 [8247072.001]
  • [Cites] N Engl J Med. 1993 May 13;328(19):1365-71 [8474513.001]
  • [Cites] N Engl J Med. 1992 Mar 5;326(10):653-7 [1736103.001]
  • [Cites] Gastroenterology. 2004 May;126(5):1247-56 [15131784.001]
  • [Cites] JAMA. 2004 Apr 14;291(14):1713-9 [15082698.001]
  • [Cites] N Engl J Med. 2003 Dec 4;349(23):2191-200 [14657426.001]
  • [Cites] JAMA. 2003 Jul 2;290(1):41-8 [12837710.001]
  • [Cites] Lancet. 2002 Apr 13;359(9314):1291-300 [11965274.001]
  • [Cites] Gastroenterology. 2001 Mar;120(4):820-6 [11231935.001]
  • [Cites] Gastroenterology. 2001 Feb;120(2):392-400 [11159880.001]
  • [Cites] Ann Intern Med. 2000 Oct 17;133(8):573-84 [11033584.001]
  • [Cites] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684.001]
  • [Cites] Gastroenterology. 2000 Nov;119(5):1219-27 [11054379.001]
  • [Cites] Gastroenterology. 2000 Sep;119(3):837-53 [10982778.001]
  • [Cites] N Engl J Med. 2000 Jul 20;343(3):169-74 [10900275.001]
  • [Cites] N Engl J Med. 2000 Jul 20;343(3):162-8 [10900274.001]
  • [Cites] N Engl J Med. 2000 Jun 15;342(24):1766-72 [10852998.001]
  • [Cites] Gastroenterology. 2000 May;118(5):829-34 [10784581.001]
  • [Cites] Gastroenterology. 2009 Feb;136(2):459-70 [19026650.001]
  • (PMID = 20431727.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852697
  • [Keywords] NOTNLM ; Adenoma / Colon cancer screening / Colonoscopy / Computed tomographic colonography / Fecal occult blood testing
  •  go-up   go-down


83. Parés D, Pera M, González S, Pascual Cruz M, Blanco I: [Familial adenomatous polyposis]. Gastroenterol Hepatol; 2006 Dec;29(10):625-35
Genetic Alliance. consumer health - Familial Polyposis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Familial adenomatous polyposis].
  • Familial adenomatous polyposis is a rare genetic disease characterized by the development of more than a hundred adenomatous polyps in the colorectal area, as well as by extracolonic manifestations.
  • Without treatment, this inherited disease, usually transmitted by autosomal dominant inheritance, predisposes to colorectal cancer.
  • Treatment must be preceded by counseling about the nature of the syndrome and by recommendations for the optimal management and surveillance of the disease.
  • This article reviews the main studies published on familial adenomatous polyposis in order to provide an update on the most appropriate management of these patients.
  • [MeSH-major] Adenomatous Polyposis Coli

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17198641.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 76
  •  go-up   go-down


84. Giardiello FM, Hylind LM, Trimbath JD, Hamilton SR, Romans KE, Cruz-Correa M, Corretti MC, Offerhaus GJ, Yang VW: Oral contraceptives and polyp regression in familial adenomatous polyposis. Gastroenterology; 2005 Apr;128(4):1077-80
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral contraceptives and polyp regression in familial adenomatous polyposis.
  • We describe a patient in the placebo arm of a 4-year primary chemoprevention trial who developed adenomatous polyps and then had eradication of polyps after the administration of oral contraceptives.
  • No change in the prostaglandin levels in the colonic mucosa was noted after polyp elimination, making nonsteroidal anti-inflammatory drug ingestion unlikely as a cause.
  • [MeSH-major] Adenomatous Polyposis Coli / physiopathology. Contraceptives, Oral / therapeutic use

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
  • Genetic Alliance. consumer health - Familial Polyposis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15825088.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 51085; United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / CA 63721; United States / NCI NIH HHS / CA / P50 CA 9316
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral; 0 / Prostaglandins
  •  go-up   go-down


85. Galimov OV, Rylova TV, Khanov VO: [Endoscopy in the diagnosis and treatment of gastric polyps]. Vestn Khir Im I I Grek; 2008;167(5):65-7
MedlinePlus Health Information. consumer health - Stomach Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endoscopy in the diagnosis and treatment of gastric polyps].
  • The authors present a clinico-statistical analysis of results of endoscopic polypectomy and dynamic observation of 258 patients with gastric polyps.
  • The aim of the investigation was to determine a true histological diagnosis of gastric polyps using excisional biopsy.
  • An endoscopic investigation has revealed 475 polyps in the stomach of 258 patients.
  • Endoscopic polypectomy by the method of electroexcision and preliminary submucous administration of solutions was used for 218 polyps having the size more than 0.5 cm.
  • Patients with formations located submucously and malignant tumors of the stomach (polypoid cancers included) were not investigated.
  • Metaplastic and dysplastic alterations characteristic of adenomatous polyps were detected by the method of chromoscopy.
  • [MeSH-major] Gastroscopy / methods. Polyps / pathology. Polyps / surgery. Stomach Diseases / pathology. Stomach Diseases / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19069827.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  •  go-up   go-down


86. Pranesh N, Haboubi NY, O'Dwyer ST: Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch. Ann R Coll Surg Engl; 2005 Jul;87(4):W1-4
MedlinePlus Health Information. consumer health - Peritoneal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch.
  • Familial adenomatous polyposis (FAP) is an autosomal dominant condition with near complete penetrance, characterised by the presence of numerous adenomatous polyps of the colon and rectum.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Lymphatic Diseases / complications. Melanosis / complications. Mesentery. Peritoneal Diseases / complications


87. Weizman AV, Nguyen GC: Colon cancer screening in 2010: an up-date. Minerva Gastroenterol Dietol; 2010 Jun;56(2):181-8
Hazardous Substances Data Bank. GUM GUAIAC .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The prognosis for limited disease is excellent; however, it becomes poor for more advanced disease.
  • The majority of colorectal cancers arise from premalignant adenomatous polyps.
  • This makes the detection of polyps and early carcinoma an attractive screening strategy.
  • [MeSH-minor] Adenomatous Polyps / complications. Guaiac. Humans. Indicators and Reagents. Occult Blood. Practice Guidelines as Topic. Predictive Value of Tests. Prognosis. Risk Factors. Sensitivity and Specificity

  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20485255.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Indicators and Reagents; 9000-29-7 / Guaiac
  • [Number-of-references] 62
  •  go-up   go-down


88. Shrubsole MJ, Wu H, Ness RM, Shyr Y, Smalley WE, Zheng W: Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps. Am J Epidemiol; 2008 May 1;167(9):1050-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps.
  • The authors evaluated alcohol drinking and cigarette smoking in relation to risk of colorectal polyps in a Nashville, Tennessee, colonoscopy-based case-control study.
  • In 2003-2005, cases with adenomatous polyps only (n = 639), hyperplastic polyps only (n = 294), and both types of polyps (n = 235) were compared with 1,773 polyp-free controls.
  • Consumption of at least five alcoholic drinks per week was not strongly associated with development of polyps.
  • Odds ratios for all polyp types were increased for dose, duration, and pack-years of cigarette smoking and were stronger for hyperplastic polyps than for adenoma.
  • Compared with never smoking, dose-response relations were particularly strong for current smoking and duration; for > or =35 years of smoking, odds ratios were 1.9 (95% confidence interval (CI): 1.4, 2.5) for adenomatous polyps only, 5.0 (95% CI: 3.3, 7.3) for hyperplastic polyps only, and 6.9 (95% CI: 4.4, 11.1) for both types of polyps.
  • Compared with current smoking, time since cessation was associated with substantially reduced odds; for > or =20 years since quitting, odds ratios were 0.4 (95% CI: 0.3, 0.6) for adenoma only, 0.2 (95% CI: 0.1, 0.3) for hyperplastic polyps only, and 0.2 (95% CI: 0.2, 0.4) for both polyp types.
  • These findings support the adverse role of cigarette smoking in colorectal tumorigenesis and suggest that quitting smoking may substantially reduce the risk of colorectal polyps.

  • MedlinePlus Health Information. consumer health - Alcohol.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Smoking.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18304959.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / P50CA950103; United States / NCI NIH HHS / CA / R01CA97386
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  •  go-up   go-down


89. Bystrovskaia EV, Il'chenko AA, Sil'vestrova SIu: [Biochemical characteristics of operating bile composition in different types of cholecystolithiasis]. Eksp Klin Gastroenterol; 2010;(6):3-6
Hazardous Substances Data Bank. CHOLESTEROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As a control, use the operating bile 6 patients with adenomatous and fibro-adenomatous polyps of the gallbladder.

  • MedlinePlus Health Information. consumer health - Cholesterol.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20731156.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Bile Acids and Salts; 0 / Phospholipids; 97C5T2UQ7J / Cholesterol
  •  go-up   go-down


90. Jeon J, Meza R, Moolgavkar SH, Luebeck EG: Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach. Math Biosci; 2008 May;213(1):56-70
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We apply these expressions to simulate the natural history of colorectal cancer and to evaluate the effect of a screen for adenomatous polyps and concomitant intervention on cancer risk.

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer. 1997 Jul 15;80(2):193-7 [9217029.001]
  • [Cites] Lancet. 1993 Mar 20;341(8847):736-40 [8095636.001]
  • [Cites] Mutat Res. 1998 May 25;400(1-2):553-78 [9685710.001]
  • [Cites] Comput Biomed Res. 1999 Feb;32(1):13-33 [10066353.001]
  • [Cites] Math Biosci. 2005 Oct;197(2):188-210 [16087198.001]
  • [Cites] Math Biosci. 2005 Oct;197(2):140-52 [16137718.001]
  • [Cites] Am J Gastroenterol. 2005 Dec;100(12):2756-8 [16393231.001]
  • [Cites] Risk Anal. 2005 Dec;25(6):1589-94 [16506984.001]
  • [Cites] J Natl Med Assoc. 2006 Jan;98(1):51-7 [16532978.001]
  • [Cites] Gut. 2006 Aug;55(8):1145-50 [16469791.001]
  • [Cites] Cancer. 2006 Oct 1;107(7):1624-33 [16933324.001]
  • [Cites] N Engl J Med. 2006 Dec 14;355(24):2533-41 [17167136.001]
  • [Cites] Nature. 2007 Jan 4;445(7123):111-5 [17122771.001]
  • [Cites] Nature. 2007 Jan 4;445(7123):106-10 [17122772.001]
  • [Cites] Am J Gastroenterol. 2006 Dec;101(12):2866-77 [17227527.001]
  • [Cites] Dig Liver Dis. 2007 Mar;39(3):242-50 [17112797.001]
  • [Cites] Br J Cancer. 2007 Mar 12;96(5):828-31 [17311019.001]
  • [Cites] Carcinogenesis. 2000 Mar;21(3):469-76 [10688867.001]
  • [Cites] Am J Gastroenterol. 2001 Mar;96(3):882-6 [11280569.001]
  • [Cites] Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15095-100 [12415112.001]
  • [Cites] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039.001]
  • [Cites] Risk Anal. 1988 Sep;8(3):383-92 [3201016.001]
  • [Cites] Risk Anal. 1989 Jun;9(2):179-87 [2762604.001]
  • [Cites] Risk Anal. 1990 Jun;10(2):323-41 [2195604.001]
  • [Cites] J Natl Cancer Inst. 1992 Apr 15;84(8):610-8 [1313509.001]
  • [Cites] Risk Anal. 1997 Jun;17(3):391-9 [9232020.001]
  • (PMID = 18374369.001).
  • [ISSN] 0025-5564
  • [Journal-full-title] Mathematical biosciences
  • [ISO-abbreviation] Math Biosci
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA107028-04; United States / NCI NIH HHS / CA / R01 CA047658; United States / NCI NIH HHS / CA / R01 CA107028; United States / NCI NIH HHS / CA / R01 CA107028-04
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS50592; NLM/ PMC2442130
  •  go-up   go-down


91. Bouguen G, Manfredi S, Blayau M, Dugast C, Buecher B, Bonneau D, Siproudhis L, David V, Bretagne JF: Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics. Dis Colon Rectum; 2007 Oct;50(10):1612-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics.
  • RESULTS: MYH mutations were identified only in the group of patients with attenuated adenomatous polyposis with ten or more adenomatous polyps.
  • Three patients presented with a family history of adenomatous polyposis in siblings, without vertical transmission.
  • The median number of colorectal adenomatous polyps was 53 without preferential localization.
  • The phenotype of the disease is similar to attenuated familial adenomatous polyposis.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. DNA Glycosylases / genetics. Mutation / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17674103.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases
  •  go-up   go-down


92. Tessonnier L, Gonfrier S, Carrier P, Valerio L, Mouroux J, Benisvy D, Viau P, Girma A, Bussière F, Darcourt J: [Unexpected focal bowel 18-FDG uptake sites: should they be systematically investigated?]. Bull Cancer; 2008 Nov;95(11):1083-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We found 25 adenomatous polyps (53.2%), 10 neoplasms (21.3%) and 4 inflammatory lesions (8.5%).
  • 18-FDG uptake values were not statistically different between the 4 groups.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonic Neoplasms / metabolism. Colonic Neoplasms / radionuclide imaging. Female. Humans. Incidental Findings. Intestinal Polyps / metabolism. Intestinal Polyps / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography / methods. Rectal Neoplasms / metabolism. Rectal Neoplasms / radionuclide imaging. Retrospective Studies. Sigmoid Neoplasms / metabolism. Sigmoid Neoplasms / radionuclide imaging. Tomography, Emission-Computed. Tomography, X-Ray Computed / methods

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19036681.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  •  go-up   go-down


93. Dworakowska D, Gueorguiev M, Kelly P, Monson JP, Besser GM, Chew SL, Akker SA, Drake WM, Fairclough PD, Grossman AB, Jenkins PJ: Repeated colonoscopic screening of patients with acromegaly: 15-year experience identifies those at risk of new colonic neoplasia and allows for effective screening guidelines. Eur J Endocrinol; 2010 Jul;163(1):21-8
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: It is suggested that patients with acromegaly have an increased risk of colorectal cancer and pre-malignant adenomatous polyps.
  • RESULTS: The presence of hyperplastic or adenomatous polyps was assessed in all patients, while one cancer was detected at the second surveillance.
  • At the third surveillance, mean (+/-s.d.) serum IGF1 levels (ng/ml) in patients with hyperplastic polyps were significantly higher than those with normal colons (P<0.05).
  • The presence of an adenoma rather than a normal colon at the first colonoscopy was associated with a significantly increased risk of adenoma at the second (odds ratio (OR) 4.4, 95% confidence interval (CI) 1.9-10.4) and at the third (OR 8.8, 95% CI 2.9-26.5) screens.
  • CONCLUSIONS: Repeated colonoscopic screening of patients with acromegaly demonstrated a high prevalence of new adenomatous and hyperplastic colonic polyps, dependent on both the occurrence of previous polyps and elevated IGF1 levels.


94. Fraser CG, Matthew CM, Mowat NA, Wilson JA, Carey FA, Steele RJ: Immunochemical testing of individuals positive for guaiac faecal occult blood test in a screening programme for colorectal cancer: an observational study. Lancet Oncol; 2006 Feb;7(2):127-31
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Screening for colorectal cancer by use of guaiac-based faecal occult blood tests (FOBT) reduces disease-specific mortality.
  • Sensitivity, specificity, and positive and negative likelihood ratios for cancer, and for cancer and high-risk adenomatous polyps were also calculated.
  • 795 individuals had data for colonoscopy: one (<1%) of 171 N/N participants and one (<1%) of 127 N/P participants had colorectal cancer, compared with 38 (8%) of 497 P/P participants; adenomatous polyps were found in 28 (16%) N/N individuals, 24 (19%) N/P individuals, and 193 (39%) P/P individuals.
  • The odds ratio for P/P being associated with cancer was 7.57 (95% CI 1.84-31.4) and with high-risk adenomatous polyps was 3.11 (1.86-5.18).
  • Sensitivity of a P/P result for cancer was 95.0% (81.8-99.1), and for cancer and high-risk adenomatous polyps was 90.1% (84.4-94.0); specificity was 39.5% (36.0-43.1) and 47.8% (43.9-51.8), respectively.

  • Genetic Alliance. consumer health - Colorectal Cancer.
  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • Hazardous Substances Data Bank. GUM GUAIAC .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Lancet Oncol. 2006 Feb;7(2):101-3 [16455472.001]
  • [CommentIn] Lancet Oncol. 2006 May;7(5):363-4 [16648040.001]
  • (PMID = 16455476.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Indicators and Reagents; 9000-29-7 / Guaiac
  •  go-up   go-down


95. Parker-Ray N, Barakat J, Roy PK, White RE, Schrader RM, Hoffman RM: Statin use does not prevent recurrent adenomatous polyp formation in a VA population. Indian J Gastroenterol; 2010 Jun;29(3):106-11
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Statin use does not prevent recurrent adenomatous polyp formation in a VA population.
  • PURPOSE: To evaluate whether statin use was associated with recurrent adenomatous polyps.
  • During follow-up, 88 (47%) of patients received statins, but use was not protective against recurrent adenomas (hazard ratio = 1.36, 95% CI 0.35-8.27).
  • Only number of polyps at initial colonoscopy predicted recurrent adenomas (1.98, 95% CI 1.27-3.08).
  • CONCLUSIONS: The use of statins was not protective against the recurrence of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. Neoplasm Recurrence, Local / prevention & control. Veterans

  • MedlinePlus Health Information. consumer health - Statins.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20658327.001).
  • [ISSN] 0975-0711
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors
  •  go-up   go-down


96. Ince AT, Bölükbas C, Peker O, Bolükbas F, Ovünç O: Pit pattern type analyses of colon polyps with high-resolution colonoscope. Hepatogastroenterology; 2007 Jan-Feb;54(73):67-70
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pit pattern type analyses of colon polyps with high-resolution colonoscope.
  • BACKGROUND/AIMS: Correlations among pit pattern types and some characteristics of colon polyps were assessed with high-resolution colonoscope in Turkish patients.
  • All visible polyps and distal 30cm of colon were stained with indigo carmine 0.4% after standard colonoscopic examination.
  • RESULTS: There were correlations among the pit pattern types of polyps and their size, location, morphology and histology.
  • Adenomatous polyps (type III,IV,V) were mostly located in the right colon, nonadenomatous polyps (type I/II) were mostly in the left.
  • Ratio of having adenomatous structure increased in a parallel course with increase in polyp's size.
  • While most of the nonadenomatous polyps were with type I,II, adenomatous polyps were with type III, IV, V patterns.
  • Most of the type II, III, IV polyps were sessile and type I polyps were flat.
  • Sensitivity and specificity of adenomatous and nonadenomatous polyps were 80% and 89% respectively and overall accuracy rate was 87%.
  • After chromoendoscopy, 35% increase in polyp number was also detected.
  • CONCLUSIONS: High-resolution endoscope is successful for prediction of histology of colorectal polyps.
  • [MeSH-major] Colonic Polyps / pathology. Colonoscopes

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17419233.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


97. John BJ, Irukulla S, Pilgrim G, Swift I, Abulafi AM: Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital. Colorectal Dis; 2008 Nov;10(9):898-900
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital.
  • INTRODUCTION: The British society of Gastroenterologists (BSG) have laid down guidelines for surveillance colonoscopies in patients with large bowel adenomatous polyps.
  • We audited our practice of polyp management and looked at guideline compliance amongst patients on our colonoscopic surveillance list.
  • METHOD: All patients undergoing adenoma surveillance and those with newly detected adenomas over a 2-month period were included in the first loop of the audit.
  • Amongst those on surveillance for polyps, compliance was ascertained as regards need for procedure and appropriateness of surveillance interval.
  • Of the patients on our colonoscopic waiting list for adenomatous polyps, 17.7% satisfied guidelines, 23.4% did not require any further surveillance and 58.9% were booked for a procedure earlier than recommended.
  • [MeSH-major] Colonic Polyps / surgery. Colonoscopy / utilization. Intestinal Polyps / surgery. Rectal Diseases / surgery

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • MedlinePlus Health Information. consumer health - Rectal Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19037930.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


98. Matusiak D, Benya RV: CYP27A1 and CYP24 expression as a function of malignant transformation in the colon. J Histochem Cytochem; 2007 Dec;55(12):1257-64
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, vitamin D precursors do not present toxicity concerns and may be sufficient for CRC chemoprevention or chemotherapy, providing the appropriate enzymes are present in colonic epithelia.
  • We previously showed that CYP27B1 is present at equally high levels in the colon and CRC irrespective of differentiation but was not present in metastases.
  • In this study we used quantitative immunohistochemistry to show that CYP27A1, converting D3 to 25-hydroxycholecalciferol, is present in increasing concentrations in the nuclei of normal colonic epithelia, aberrant crypt foci (ACF), and adenomatous polyps.
  • Similarly, increasing amounts of the deactivating enzyme CYP24 are present in the nuclei of normal colonic epithelia, ACFs, and adenomatous polyps.
  • [MeSH-minor] Adenomatous Polyps / enzymology. Adenomatous Polyps / ultrastructure. Colon / enzymology. Colon / pathology. Colon / ultrastructure. Humans. Immunohistochemistry. Intestinal Mucosa / enzymology. Intestinal Mucosa / ultrastructure. Lymphatic Metastasis. Vitamin D3 24-Hydroxylase

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17875655.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-094346
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.14.- / Steroid Hydroxylases; EC 1.14.13.126 / Vitamin D3 24-Hydroxylase; EC 1.14.13.15 / CYP27A1 protein, human; EC 1.14.13.15 / Cholestanetriol 26-Monooxygenase
  •  go-up   go-down


99. Wassenaar MJ, Cazemier M, Biermasz NR, Pereira AM, Roelfsema F, Smit JW, Hommes DW, Felt-Bersma RJ, Romijn JA: Acromegaly is associated with an increased prevalence of colonic diverticula: a case-control study. J Clin Endocrinol Metab; 2010 May;95(5):2073-9
Faculty of 1000. commentaries/discussion - See the articles recommended by F1000Prime's Faculty of more than 8,000 leading experts in Biology and Medicine. (subscription/membership/fee required).

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We screened reports of colonoscopies performed for the purpose of screening for polyps in 107 patients with cured or biochemically controlled acromegaly and in 214 age- and sex-matched controls for the presence of diverticula, dolichocolon, and polyps.
  • RESULTS: In acromegaly, colonic diverticula were present in 37% of patients, dolichocolon in 34%, and adenomatous polyps in 34%, which was increased compared with controls (odds ratio 3.6, 95% confidence interval 1.4, 5.7; 12.4, 95% confidence interval 6.8, 18.0; 4.1, 95% confidence interval 1.9, 6.4, respectively).
  • The presence of colonic diverticula was associated with both GH and IGF-I concentrations at the time of diagnosis of acromegaly, when adjusted for the duration of active disease.
  • The presence of dolichocolon and adenomatous polyps was associated with higher IGF-I concentrations at diagnosis.
  • [MeSH-minor] Adenomatous Polyposis Coli / epidemiology. Adenomatous Polyposis Coli / surgery. Aging. Biopsy. Case-Control Studies. Colon, Sigmoid / pathology. Colonic Polyps / epidemiology. Colonic Polyps / surgery. Colonoscopy. Confidence Intervals. Dietary Fiber / deficiency. Female. Growth Hormone / blood. Humans. Male. Prevalence. Reference Values. Risk Factors

  • Genetic Alliance. consumer health - Acromegaly.
  • MedlinePlus Health Information. consumer health - Diverticulosis and Diverticulitis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20215398.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-72-6 / Growth Hormone
  •  go-up   go-down


100. Gurudu SR, Heigh RI, De Petris G, Heigh EG, Leighton JA, Pasha SF, Malagon IB, Das A: Sessile serrated adenomas: demographic, endoscopic and pathological characteristics. World J Gastroenterol; 2010 Jul 21;16(27):3402-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma (SSA) in a single center.
  • A retrospective chart review was performed to extract data on demographics, polyp characteristics, presence of synchronous adenomatous polyps or cancer, polypectomy methods, and related complications.
  • The mean (SE) size of the SSAs was 8.1 (0.4) mm; 42% of SSAs were < or = 5 mm, and 69% were < or = 9 mm.
  • Approximately half of the patients had synchronous polyps of other histological types, including hyperplastic and adenomatous polyps.
  • Ninety-seven percent of polyps were removed by colonoscopy.
  • CONCLUSION: Among patients with colon polyps, 2.9% were found to have SSAs.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Polyps / pathology

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Pathol. 2001 Mar;193(3):286-94 [11241406.001]
  • [Cites] Gastrointest Endosc. 2009 Dec;70(6):1182-99 [19879563.001]
  • [Cites] Am J Clin Pathol. 2003 Jun;119(6):773-5 [12817423.001]
  • [Cites] Am J Clin Pathol. 2003 Jun;119(6):778-96 [12817424.001]
  • [Cites] J Clin Pathol. 2004 Jul;57(7):682-6 [15220357.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Am J Surg Pathol. 1990 Jun;14(6):524-37 [2186644.001]
  • [Cites] Cancer Res. 1997 Mar 1;57(5):808-11 [9041175.001]
  • [Cites] J Clin Pathol. 1999 Jan;52(1):5-9 [10343605.001]
  • [Cites] Gastroenterology. 2006 May;130(6):1872-85 [16697750.001]
  • [Cites] World J Gastroenterol. 2006 May 7;12(17):2770-2 [16718767.001]
  • [Cites] Gastroenterology. 2006 Nov;131(5):1400-7 [17101316.001]
  • [Cites] Histopathology. 2007 Jan;50(1):131-50 [17204027.001]
  • [Cites] World J Gastroenterol. 2007 Jul 28;13(28):3792-8 [17657832.001]
  • [Cites] Gastroenterol Clin North Am. 2007 Dec;36(4):947-68, viii [17996799.001]
  • [Cites] Am J Surg Pathol. 2008 Jan;32(1):21-9 [18162766.001]
  • [Cites] Am J Surg Pathol. 2008 Jan;32(1):30-5 [18162767.001]
  • [Cites] Digestion. 2008;77(3-4):178-83 [18617741.001]
  • [Cites] Curr Gastroenterol Rep. 2008 Oct;10(5):490-8 [18799125.001]
  • [Cites] Gastroenterology. 2008 Oct;135(4):1100-5 [18691580.001]
  • [Cites] Dig Dis Sci. 2009 Apr;54(4):906-9 [18688718.001]
  • [Cites] J Clin Oncol. 2002 Feb 15;20(4):1043-8 [11844828.001]
  • (PMID = 20632442.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2904886
  •  go-up   go-down






Advertisement