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1. Yuan B, Jin X, Zhu R, Zhang X, Liu J, Wan H, Lu H, Shen Y, Wang F: Cronkhite-Canada syndrome associated with rib fractures: a case report. BMC Gastroenterol; 2010;10:121
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cronkhite-Canada syndrome (CCS) is a rare multiple gastrointestinal polyposis.
  • Up till now, many complications of CCS have been reported in the literature, but rib fracture is not included.
  • CASE PRESENTATION: We report a case of a 58-year-old man who was admitted to our hospital with a 6-month history of frequent diarrhea, intermittent hematochezia and a weight loss of 13 kg.
  • Esophagogastroduodenoscopy, video capsule endoscopy and colonoscopy revealed various sizes of generalized gastrointestinal polyps.
  • Histological examination of the biopsy specimens obtained from the stomach and the colon showed adenomatous polyp and inflammatory polyp respectively.
  • Thus, a diagnosis of CCS was made.
  • Examinations, including emission computed tomography, bone densitometry test, and other serum parameters, were performed, but could not identify the definite etiology of the rib fractures.
  • CONCLUSIONS: This is the first case of a CCS patient with multiple rib fractures.
  • Although the association between CCS and multiple rib fractures in this case remains uncertain, we presume that persistent hypocalcaemia and malnutrition contribute to this situation, or at least aggravate this rare complication.
  • [MeSH-minor] Endoscopy, Gastrointestinal. Follow-Up Studies. Humans. Male. Middle Aged. Radiography, Thoracic

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  • (PMID = 20955587.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2972238
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2. Beaton MD, Taylor B, Driman D, Ainsworth P, Adams PC: Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation? Can J Gastroenterol; 2008 Jul;22(7):634-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation?
  • Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps.
  • The present paper describes a case of a woman diagnosed with colorectal cancer at 34 years of age and subsequently found to have AFAP by genetic testing.
  • While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach.
  • Therefore, various environmental differences between the upper and lower gastrointestinal tract may play a role in the expression of AFAP phenotype.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colonic Polyps / pathology

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  • (PMID = 18629394.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2661270
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3. Rio Frio T, Lavoie J, Hamel N, Geyer FC, Kushner YB, Novak DJ, Wark L, Capelli C, Reis-Filho JS, Mai S, Pastinen T, Tischkowitz MD, Marcus VA, Foulkes WD: Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. N Engl J Med; 2010 Dec 30;363(27):2628-37
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia.
  • A patient received a diagnosis of adenocarcinoma of the ampulla of Vater at 34 years of age.
  • Two decades later, adenomatous polyps were found, followed by multiple primary invasive adenocarcinomas of both the colon and the stomach.
  • We identified a germline homozygous intronic mutation, c.2386-11A→G, in the spindle-assembly checkpoint gene BUB1B, which creates a de novo splice site that is favored over the authentic (i.e., preferentially used) site.
  • Our findings expand the phenotype associated with BUB1B mutations and the mosaic variegated aneuploidy syndrome to include common adult-onset cancers and provide evidence for the interdependency of the APC protein (encoded by the adenomatous polyposis coli gene) and the BUBR1 protein (encoded by BUB1B) in humans. (Funded by the Turner Family Cancer Research Fund and others.).
  • [MeSH-major] Gastrointestinal Neoplasms / genetics. Genetic Predisposition to Disease. Germ-Line Mutation. Protein-Serine-Threonine Kinases / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adenomatous Polyposis Coli Protein / genetics. Adenomatous Polyposis Coli Protein / metabolism. Aged. Chromosome Disorders / genetics. DNA Mutational Analysis. Female. Genomic Instability. Homozygote. Humans. Karyotyping. Male. Mosaicism. Oligonucleotide Array Sequence Analysis. Pedigree. Phenotype. Spindle Apparatus

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  • [CommentIn] N Engl J Med. 2010 Dec 30;363(27):2665-6 [21190461.001]
  • [CommentIn] N Engl J Med. 2011 Mar 31;364(13):1279-80 [21449797.001]
  • (PMID = 21190457.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; Mosaic variegated aneuploidy syndrome
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4. Kim MS, Jung HK, Jung HS, Choi JY, Na YJ, Pyun GW, Ryu JH, Moon IH, Jo MS: [A Case of Cronkhite-Canada syndrome showing resolution with Helicobacter pylori eradication and omeprazole]. Korean J Gastroenterol; 2006 Jan;47(1):59-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a 58-year-old woman who was incidentally found to have gastric and colonic polyposis, hypoalbuminemia, cutaneous hyperpigmentation and onychodystrophy (Cronkhite-Canada syndrome).
  • Histology of polyps from the stomach showed features of juvenile or retention type (hamartomatous) polyps with Helicobacter pylori (H. pylori) infection.
  • The large pedunculated colonic polyps showed hamartomatous polyps with adenomatous component and polypectomy was performed.
  • After the treatment with H. pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed.
  • The experience of this case suggests that eradication of H. pylori and proton pump inhibitor treatment might be considered in patients with gastric polyposis combined with Cronkhite-Canada syndrome.
  • [MeSH-major] Anti-Ulcer Agents / therapeutic use. Helicobacter Infections / drug therapy. Helicobacter pylori. Omeprazole / therapeutic use. Polyps / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Colonic Polyps / complications. Colonic Polyps / microbiology. Colonic Polyps / pathology. Female. Humans. Hyperpigmentation / pathology. Middle Aged. Nails, Malformed / pathology. Proton Pump Inhibitors. Syndrome

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  • (PMID = 16434870.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Proton Pump Inhibitors; KG60484QX9 / Omeprazole
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5. Hizawa K, Yamamoto H, Yao T, Aomi H, Nakahara T, Matsumoto T, Iida M: [Gastric foveolar type adenomatous polyp arising in the duodenum]. Nihon Shokakibyo Gakkai Zasshi; 2005 Aug;102(8):1035-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gastric foveolar type adenomatous polyp arising in the duodenum].
  • [MeSH-major] Adenomatous Polyps / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 16124710.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Tescher P, Macrae FA, Speer T, Stella D, Gibson R, Tye-Din JA, Srivatsa G, Jones IT, Marion K: Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps. Hered Cancer Clin Pract; 2010;8(1):3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps.
  • BACKGROUND: Familial adenomatous polyposis (FAP) is a hereditary disorder characterized by polyposis along the gastrointestinal tract.
  • Information on adenoma status below the duodenum has previously been restricted due to its inaccessibility in vivo.
  • This study aims to evaluate the effectiveness of CE in the assessment of patients with FAP, compared to other imaging modalities for the detection of small bowel polyps.
  • METHOD: 20 consecutive patients with previously diagnosed FAP and duodenal polyps, presenting for routine surveillance of polyps at The Royal Melbourne Hospital were recruited.
  • An upper gastrointestinal side-viewing endoscopy was done one (1) to two (2) weeks after this.
  • RESULTS: Within the stomach, upper gastrointestinal endoscopy found more polyps than other forms of imaging.
  • SBFT and MRI generally performed poorly, identifying fewer polyps than both upper gastrointestinal and capsule endoscopy.
  • CE was the only form of imaging that identified polyps in all segments of the small bowel as well as the only form of imaging able to provide multiple findings outside the stomach/duodenum.
  • CONCLUSION: CE provides important information on possible polyp development distal to the duodenum, which may lead to surgical intervention.

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  • (PMID = 20361877.001).
  • [ISSN] 1897-4287
  • [Journal-full-title] Hereditary cancer in clinical practice
  • [ISO-abbreviation] Hered Cancer Clin Pract
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7. Kon OL, Yip TT, Ho MF, Chan WH, Wong WK, Tan SY, Ng WH, Kam SY, Eng AKh, Ho P, Viner R, Ong HS, Kumarasinghe MP: The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile. BMC Med Genomics; 2008;1:54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile.
  • BACKGROUND: Overall gastric cancer survival remains poor mainly because there are no reliable methods for identifying highly curable early stage disease.
  • Multi-protein profiling of gastric fluids, obtained from the anatomic site of pathology, could reveal diagnostic proteomic fingerprints.
  • METHODS: Protein profiles were generated from gastric fluid samples of 19 gastric cancer and 36 benign gastritides patients undergoing elective, clinically-indicated gastroscopy using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry on multiple ProteinChip arrays.
  • A second blinded sample set (24 gastric cancers and 29 clinically benign gastritides) was used for validation.
  • RESULTS: By significance analysyis of microarray, 60 proteomic features were up-regulated and 46 were down-regulated in gastric cancer samples (p < 0.01).
  • Eighteen of 19 cancer samples clustered together (sensitivity 95%) while 27/36 of non-cancer samples clustered in a second group.
  • Nine non-cancer samples that clustered with cancer samples included 5 pre-malignant lesions (1 adenomatous polyp and 4 intestinal metaplasia).
  • CONCLUSION: This simple and reproducible multimarker proteomic assay could supplement clinical gastroscopic evaluation of symptomatic patients to enhance diagnostic accuracy for gastric cancer and pre-malignant lesions.

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  • (PMID = 18950519.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2584050
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8. Fujimura T, Ohta T, Oyama K, Miyashita T, Miwa K: Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. World J Gastroenterol; 2006 Mar 7;12(9):1336-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience.
  • However,coxibs also have an ability to inhibit tumor development of various kinds the same way that NSAIDs do.
  • Many experimental studies using cell lines and animal models demonstrated an ability to prevent tumor proliferation of COX-2 inhibitors.
  • After performing a randomized study for polyp chemoprevention study in patients with familial adenomatous polyposis (FAP),which showed that the treatment with celecoxib, one of the coxibs, significantly reduced the number of colorectal polyps in 2000, the U.S.
  • In this article we review a role of COX-2 in carcinogenesis of gastrointestinal tract, such as the esophagus, stomach and colorectum,and also analyze the prospect of coxibs for chemoprevention of gastrointestinal tract tumors.
  • [MeSH-major] Cyclooxygenase 2 / physiology. Gastrointestinal Neoplasms / etiology
  • [MeSH-minor] Adenomatous Polyposis Coli / drug therapy. Cardiovascular Diseases / chemically induced. Cardiovascular Diseases / physiopathology. Cell Proliferation / drug effects. Colorectal Neoplasms / etiology. Colorectal Neoplasms / prevention & control. Cyclooxygenase 2 Inhibitors / adverse effects. Cyclooxygenase 2 Inhibitors / pharmacology. Cyclooxygenase 2 Inhibitors / therapeutic use. Dinoprostone / metabolism. Esophageal Neoplasms / etiology. Esophageal Neoplasms / prevention & control. Humans. Intestinal Mucosa / chemistry. Intestinal Mucosa / metabolism. RNA, Messenger / analysis. Risk Factors. Stomach Neoplasms / etiology. Stomach Neoplasms / prevention & control

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  • (PMID = 16552798.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / RNA, Messenger; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
  • [Number-of-references] 92
  • [Other-IDs] NLM/ PMC4124307
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9. Mabrut JY, Romagnoli R, Collard JM, Saurin JC, Detry R, Mion F, Baulieux J, Kartheuser A: Familial adenomatous polyposis predisposes to pathologic exposure of the stomach to bilirubin. Surgery; 2006 Nov;140(5):818-23
Genetic Alliance. consumer health - Familial Polyposis.

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  • [Title] Familial adenomatous polyposis predisposes to pathologic exposure of the stomach to bilirubin.
  • BACKGROUND: The role of duodenogastric reflux in the genesis of gastric polyps in familial adenomatous polyposis (FAP), although suggested by scintigraphy scanning studies, remains unclear.
  • METHODS: Twenty-four hour intragastric bilirubin monitoring with the Bilitec optoelectronic device was carried out in 25 FAP patients, of whom 19 had gastric polyps (fundic gland in 13, adenomatous in 2, and both histologic types in 4) on endoscopic examination.
  • Gastric exposure to bilirubin was expressed as the percentage of total recording time that absorbance exceeded the threshold of 0.25 and was calculated in reference to values obtained from 25 healthy volunteers.
  • Helicobacter pylori status of the stomach was checked as well.
  • RESULTS: Gastric exposure to bilirubin was pathologic in 14 (56%) patients.
  • Gastric exposure to bilirubin was of longer duration in FAP patients than in healthy volunteers (mean+/-SEM: 19%+/-4% vs 6%+/-2%) (P<.005).
  • It increased from healthy volunteers (6%+/-2%) to FAP patients without gastric polyps (10%+/-3%), and to FAP patients with gastric polyps (22%+/-5%) (P<.004).
  • Bilirubin exposure times were similar in FAP patients with fundic gland polyps only and in those having either adenomatous polyps only or both types of polyps (24%+/-7% vs 17%+/-4%).
  • No patient with pathologic gastric exposure to bilirubin as well as none having gastric polyps, had H. pylori in the antrum.
  • CONCLUSIONS: This study shows that gastric exposure to bilirubin is of longer duration in FAP patients than in healthy volunteers, and in FAP patients with gastric polyps than in those without polyps.
  • This study supports the existence of a direct correlation between pathologic duodenogastric reflux (DGR), the absence of H. pylori in the antrum, and the presence of gastric polyps in FAP patients.
  • [MeSH-major] Adenomatous Polyposis Coli / physiopathology. Bilirubin / physiology. Duodenogastric Reflux / physiopathology. Polyps / physiopathology. Stomach / physiopathology

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  • (PMID = 17084726.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] RFM9X3LJ49 / Bilirubin
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10. Neneman B, Gasiorowska A, Małecka-Panas E: The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon. Adv Med Sci; 2006;51:88-93
Hazardous Substances Data Bank. Argon, Elemental .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon.
  • PURPOSE: Endoscopic treatment of sessile and semipedunculated polyps remains controversial.
  • Residual tissue remains frequently after endoscopic snare polypectomy.
  • The aim of the study was to assess the outcome and safety of argon plasma coagulation (APC) in the management of gastric and colorectal polyp remnants after polypectomy, and to search for clinical parameters useful in predicting the efficacy of this technique.
  • MATERIAL AND METHODS: This prospective study comprised 18 patients with gastric polyps and 29 with colonic polyps found in upper and lower GI endoscopy.
  • Overall 22 gastric polyps and 58 colonic polyps have been detected.
  • All those polyps were removed at colonoscopy with the diathermic snare and the polyp remnants were destroyed with APC using Argon Beamer source (Erbe, Germany).
  • RESULTS: Pathologic examination revealed 10 hyperplastic polyps and 12 tubular adenomas of the stomach.
  • Effective destruction of polyp remnants was achieved in 20 (90.9%) gastric polyps in 16 (88.9%) patients.
  • Significant positive correlation was demonstrated between the power output, APC sessions number and polyp location in the prepyloric part, its size and adenomatous content.
  • Among colonic polyps there were: 17 hyperplastic, 26 tubular, 8 tubulo-villous, 4 villous adenomas and 3 inflammatory pseudopolyps.
  • Effective destruction of remnant polyp tissue was obtained in 56 (96.4%) polyps in 27 (93.1%) patients.
  • A significant positive correlation between the power output and the size, distal location and villous texture of the polyp has been demonstrated.
  • CONCLUSIONS: APC is an effective and safe method in the management of polyp remnants in the stomach and colon.
  • The application of higher electric power and numerous APC sessions are necessary to remove residues of large gastric polyps located in the prepyloric part and of with adenomatous content.
  • In the case of colonic polyps the application of higher electric power should be recommended in case of large-sized lesions, located in rectum and of villous texture.
  • [MeSH-major] Colonic Polyps / surgery. Electrocoagulation / methods. Neoplasm, Residual / surgery. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adult. Aged. Argon / therapeutic use. Colonoscopy. Endoscopy. Female. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 17357283.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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11. Sotnikov VN, Dubinskaia TK, Sotnikov AV, Ageĭkina NV, Margarian LA, Vyshegurov KhKh: [Polyposis of the stomach. Endoscopic treatment or follow-up?]. Khirurgiia (Mosk); 2007;(1):38-42
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Polyposis of the stomach. Endoscopic treatment or follow-up?].
  • Out of 3243 patients with gastric polips, polyposis was diagnosed in 298 ones including 135 cases of complicated and 163 cases of uncomplicated forms.
  • Along with hyperplastic polyps, solitary adenomas were diagnosed in 9 cases, Peitz-Jegerc polyps - in 6, and juvenile polyps - in 2.
  • There were no cases of polyp transformation into cancer.
  • Open surgical treatment was not performed.
  • [MeSH-major] Endoscopy. Polyps. Stomach Neoplasms
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hyperplasia. Male. Middle Aged. Peutz-Jeghers Syndrome / diagnosis. Peutz-Jeghers Syndrome / pathology. Reoperation. Stomach / pathology. Time Factors

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  • (PMID = 17426688.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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12. Chakraborti AK, Garg SK, Kumar R, Motiwala HF, Jadhavar PS: Progress in COX-2 inhibitors: a journey so far. Curr Med Chem; 2010;17(15):1563-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Their use is associated with side effects such as gastrointestinal and renal toxicity.
  • A number of selective (second generation) COX-2 inhibitors (rofecoxib, celecoxib, valdecoxib etc.) were developed as safer NSAIDs with improved gastric safety profile.
  • Observation of increased cardiovascular risks in APPROVe (Adenomatous Polyp Prevention on Vioxx) study sent tremors and led to voluntary withdrawn of Vioxx (rofecoxib) by Merck from the market in September 2004 followed by Bextra (valdecoxib) in 2005 raising a question on the safety of selective COX-2 inhibitors.
  • Recognition of new avenues for selective COX-2 inhibitors such as cancer, Alzheimer's disease, Parkinson's disease, schizophrenia, major depression, ischemic brain injury and diabetic peripheral nephropathy has kindled the interest in these compounds.

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  • (PMID = 20166930.001).
  • [ISSN] 1875-533X
  • [Journal-full-title] Current medicinal chemistry
  • [ISO-abbreviation] Curr. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Heterocyclic Compounds; 0 / Lactones; 0 / Sulfones; 0 / lumiracoxib; 0QTW8Z7MCR / rofecoxib; 144O8QL0L1 / Diclofenac; EC 1.14.99.1 / Cyclooxygenase 2
  • [Number-of-references] 164
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13. Levi Z, Vilkin A, Niv Y: Esophago-gastro-duodenoscopy is not indicated in patients with positive immunochemical test and nonexplanatory colonoscopy. Eur J Gastroenterol Hepatol; 2010 Dec;22(12):1431-4
MedlinePlus Health Information. consumer health - Gastrointestinal Bleeding.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Esophago-gastro-duodenoscopy is not indicated in patients with positive immunochemical test and nonexplanatory colonoscopy.
  • OBJECTIVES: Patients with positive fecal occult blood test and unrevealing colonoscopy are often advised to undergo esophago-gastro-duodenoscopy (EGD) to exclude a bleeding source in the upper gastrointestinal tract.
  • In this study, we evaluated EGD findings in patients with positive immunochemical fecal occult blood test (I-FOBT) not explained by colonoscopy.
  • METHODS: Out of 1221 consecutive patients having total colonoscopy after preparing I-FOBT (OC-MICRO, with threshold of 75 or 100 ngHb/ml), we included only patients without colorectal cancer or advanced adenomatous polyp on colonoscopy, who also underwent EGD within 4 months of the fecal blood testing.
  • The procedure was performed 1.6 ± 1.4 months after the I-FOBT.
  • CONCLUSION: Immunological FOBT positivity was not correlated with the finding of lesions, which are likely to bleed on EGD.
  • Thus, EGD is probably not indicated in patients with positive I-FOBT and unrevealing colonoscopy.
  • [MeSH-major] Colonoscopy. Endoscopy, Digestive System. Gastrointestinal Hemorrhage / diagnosis. Immunohistochemistry. Occult Blood. Patient Selection

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  • (PMID = 20962660.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Wong DC, Wong SK, Leung AL, Chung CC, Li MK: Combined endolaparoscopic intragastric excision for gastric neoplasms. J Laparoendosc Adv Surg Tech A; 2009 Dec;19(6):765-70
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined endolaparoscopic intragastric excision for gastric neoplasms.
  • BACKGROUND: The aim of this study was to describe our technique of combined endolaparoscopic approach to the management of intraluminal gastric neoplasms and to review the clinical outcome.
  • METHODS: Between February 2006 and January 2008, a total of 12 patients with gastric neoplasm < or =4 cm with a mainly intraluminal component received the combined endolaparoscopic intragastric excision and were prospectively analyzed.
  • RESULTS: Eight of 12 lesions were gastrointestinal stromal tumours.
  • The remaining lesions were adenomatous polyp with focal intramucosal adenocarcinoma, leiomyoma, and pancreatic heterotopia.
  • CONCLUSIONS: This combined endolaparoscopic intragastric excision technique is a truly minimally invasive alternative for selected gastric neoplasm.
  • [MeSH-major] Gastrectomy / methods. Gastrointestinal Stromal Tumors / surgery. Gastroscopy / methods. Laparoscopy / methods. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Aged, 80 and over. Carcinoma / pathology. Carcinoma / surgery. Cohort Studies. Female. Humans. Leiomyoma / pathology. Leiomyoma / surgery. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 19645605.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Galimov OV, Rylova TV, Khanov VO: [Endoscopy in the diagnosis and treatment of gastric polyps]. Vestn Khir Im I I Grek; 2008;167(5):65-7
MedlinePlus Health Information. consumer health - Stomach Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endoscopy in the diagnosis and treatment of gastric polyps].
  • The authors present a clinico-statistical analysis of results of endoscopic polypectomy and dynamic observation of 258 patients with gastric polyps.
  • The aim of the investigation was to determine a true histological diagnosis of gastric polyps using excisional biopsy.
  • An endoscopic investigation has revealed 475 polyps in the stomach of 258 patients.
  • Endoscopic polypectomy by the method of electroexcision and preliminary submucous administration of solutions was used for 218 polyps having the size more than 0.5 cm.
  • Patients with formations located submucously and malignant tumors of the stomach (polypoid cancers included) were not investigated.
  • Metaplastic and dysplastic alterations characteristic of adenomatous polyps were detected by the method of chromoscopy.
  • [MeSH-major] Gastroscopy / methods. Polyps / pathology. Polyps / surgery. Stomach Diseases / pathology. Stomach Diseases / surgery

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  • (PMID = 19069827.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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16. Goddard AF, Badreldin R, Pritchard DM, Walker MM, Warren B, British Society of Gastroenterology: The management of gastric polyps. Gut; 2010 Sep;59(9):1270-6
MedlinePlus Health Information. consumer health - Stomach Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The management of gastric polyps.
  • BACKGROUND: Gastric polyps are important as some have malignant potential.
  • If such polyps are left untreated, gastric cancer may result.
  • The malignant potential depends on the histological type of the polyp.
  • DEFINITION: Gastric polyps are sessile or pedunculated lesions that originate in the gastric epithelium or submucosa and protrude into the stomach lumen.
  • MALIGNANT POTENTIAL: Depending on histological type, some gastric polyps (adenomas and hyperplastic polyps) have malignant potential and are precursors of early gastric cancer.
  • They may also indicate an increased risk of intestinal or extra-intestinal malignancy.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Evidence-Based Medicine / methods. Gastroscopy / methods. Humans. Precancerous Conditions / diagnosis. Precancerous Conditions / surgery. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery

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  • (PMID = 20675692.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Review
  • [Publication-country] England
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17. Mandir N, Goodlad RA: Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer. Cell Prolif; 2008 Apr;41(2):279-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjugated linoleic acids differentially alter polyp number and diameter in the Apc(min/+) mouse model of intestinal cancer.
  • MATERIALS AND METHODS: The effects of the predominant forms of CLA, namely the c9t11 and t10c12 isomers, or a mixture of these on polyp development, were investigated in the Apc(Min/+) mouse.
  • CLAs have also been linked to altered rates of cell renewal and cell proliferation so this was also studied, as was a further means of increasing tissue mass, namely crypt fission.
  • RESULTS: The stomach and small intestine were significantly heavier in the t10c12, and in the mixture-treated groups (P < 0.001).
  • The t10c12 and the mixture significantly reduced polyp number in the proximal small intestine but they increased polyp diameter in the middle and distal small intestine, to an extent that the polyp burden was significantly increased at these sites.
  • All CLAs significantly reduced polyp number in the colon, but the mixture significantly increased polyp diameter in the colon.
  • CONCLUSION: Increased polyp diameter associated with t10c12 diet and especially with the mixture is a cause of concern, as this is the commercially available form.
  • The naturally occurring isomer, c9t11 decreased colonic polyp number and did not increase diameter, suggesting that this natural isomer is the most likely to be protective.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Intestinal Neoplasms / prevention & control. Intestinal Polyps / drug therapy. Linoleic Acids, Conjugated / administration & dosage
  • [MeSH-minor] Animals. Cell Proliferation / drug effects. Chemoprevention. Dietary Supplements. Disease Models, Animal. Female. Isomerism. Male. Mice. Mice, Inbred C57BL. Mitosis / drug effects. beta Catenin / metabolism

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  • (PMID = 18336472.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Linoleic Acids, Conjugated; 0 / beta Catenin; 0 / cis-9, trans-11-conjugated linoleic acid; 0 / trans-10,cis-12-conjugated linoleic acid
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18. Kawase R, Nagata S, Onoyama M, Nakayama N, Honda Y, Kuwahara K, Kimura S, Tsuji K, Ohgoshi H, Sakatani A, Kaneko M, Ito M, Shimamoto F, Hidaka T: A case of gastric adenocarcinoma arising from a fundic gland polyp. Clin J Gastroenterol; 2009 Aug;2(4):279-283

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of gastric adenocarcinoma arising from a fundic gland polyp.
  • A rare case of gastric adenocarcinoma arising on the surface of a fundic gland polyp is reported.
  • A 36-year-old Japanese woman was referred to our hospital for examination and treatment of a polyp that had been detected in another hospital.
  • She did not have a history of familial adenomatous polyposis (FAP).
  • Endoscopic examination revealed a 10-mm-diameter fundic gland polyp in the body of the stomach.
  • The polyp had an irregular depression on its top, suggesting the presence of malignancy.
  • Endoscopic mucosal resection was done to make a histological diagnosis.
  • This revealed a fundic gland polyp with a tiny superficial adenocarcinoma.
  • Atrophic changes of the gastric mucosa were mild, although Helicobacter pylori infection was positive.
  • It is suggested that fundic gland polyps have the potential for malignant transformation.

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  • [Cites] Clin Gastroenterol Hepatol. 2008 Feb;6(2):180-5 [18237868.001]
  • [Cites] Gut. 2002 Nov;51(5):742-5 [12377817.001]
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  • (PMID = 26192425.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Adenocarcinoma / Fundic gland polyp / Helicobacter pylori
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19. Frazzetta M, Raimondo D, Furgiuele G, Sammartano A, Romito F, Frazzetta F, Lucania M, Piccolo CL, Bonventre S: Gastric polypoid lesions. Our experience. G Chir; 2010 Apr;31(4):162-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric polypoid lesions. Our experience.
  • BACKGROUND AND AIM: The Authors report the results of their experience on polypoids lesions of the stomach and on endoscopic polypectomies.
  • PATIENTS AND METHODS: A study on 2000 OGD (oesophagogastroduodenoscopy) has been carried out on 95 patients with polypoid lesions.
  • RESULTS: In the majority of the cases, the polypoid lesions were asymptomatic, the localization changed according to the histological type, with the antrum as the most affected area.
  • The presence of Helicobacter pylori does not seem to be correlated to the lesion, except in the case of hyperplastic polyps.
  • The percentage of risks of cancerization increased in case of adenomatous polyps.
  • In one patient signet ring cell carcinoma within a gastric polyp was found.
  • Gastric signet ring cell carcinomas are peculiar for their rarity as well as for the growth in polypoid lesions.
  • CONCLUSION: We confirm the higher frequency of hyperplastic polyps and the correlation between histological type and localization.
  • Endoscopic polipectomy is the first approach in gastric polyps, with lower risk of developing cancer.
  • [MeSH-major] Polyps / surgery. Stomach Diseases / surgery

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  • (PMID = 20444334.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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20. Mizuno S, Morita Y, Inui T, Asakawa A, Ueno N, Ando T, Kato H, Uchida M, Yoshikawa T, Inui A: Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy. Int J Cancer; 2005 Dec 20;117(6):1058-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy.
  • Helicobacter pylori (H. pylori) is associated with the development of cancer in the stomach, but both positive and negative associations were reported with colorectal neoplasia.
  • We sought to determine whether H. pylori is associated with colon neoplasia in Japanese population.
  • A significant increase in the incidence of adenomatous polyps (p < 0.0001) and decrease in normal colonoscopic findings (p < 0.0005) were observed in seropositive patients than those seronegative.
  • Our study indicates an etiological link of H. pylori infection to colorectal neoplasia and the need of routine colonoscopy in seropositive patients.
  • [MeSH-major] Adenomatous Polyps / microbiology. Colonic Neoplasms / microbiology. Colonic Polyps / microbiology. Colonoscopy. Helicobacter Infections. Helicobacter pylori

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • [CommentIn] Int J Cancer. 2006 Oct 15;119(8):1999-2000 [16708392.001]
  • (PMID = 15986436.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Immunoglobulin G
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21. Hsu WH, Wu IC, Kuo CH, Su YC, Lu CY, Kuo FC, Jan CM, Wang WM, Wu DC, Yu FJ: Influence of proton pump inhibitor use in gastrointestinal polyps. Kaohsiung J Med Sci; 2010 Feb;26(2):76-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of proton pump inhibitor use in gastrointestinal polyps.
  • However, because hypergastrinemia is related to the occurrence of colonic adenomatous polyps, the purpose of this study was to analyze the relationship between the occurrence of gastrointestinal polyps and hypergastrinemia induced by PPIs.
  • Any subtle polypoid lesions in the stomach and colon were sampled by biopsy for histological examination.
  • A total of 122 patients were receiving PPI treatment for either peptic ulcer disease or reflux esophagitis and were included as the study group.
  • The remaining 137 patients were not treated with PPIs and served as the non-PPI group.
  • Although the prevalence of gastric gland polyps was higher in the PPI group (65.6% vs. 37.2%, p < 0.001), there was no difference in the prevalence of colonic adenomatous polyps observed (22.13% vs. 22.62%, p = 0.928).
  • In conclusion, the prevalence of gastric polyps, particularly fundic gland polyps, was higher among PPI users.
  • However, the prevalence of colonic polyps was not affected by PPI use, regardless of past history of colonic adenomatous polyps.
  • [MeSH-major] Anti-Ulcer Agents / adverse effects. Gastrointestinal Diseases / drug therapy. Polyps / drug therapy. Proton Pump Inhibitors / adverse effects

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  • (PMID = 20123595.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Proton Pump Inhibitors
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22. Bartosova Z, Zavodna K, Krivulcik T, Usak J, Mlkva I, Kruzliak T, Hromec J, Usakova V, Kopecka I, Veres P, Bartosova Z, Bujalkova M: STK11/LKB1 germline mutations in the first Peutz-Jeghers syndrome patients identified in Slovakia. Neoplasma; 2007;54(2):101-7
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  • Peutz-Jeghers syndrome (PJS) is characterized by number of hamartomatous polyps in the gastrointestinal tract and by mucocutaneous hypermelanocytic lesions at different sites.
  • Older patients have an increased risk of the cancers of small intestine, stomach, pancreas, colon, esophagus, ovary, testis, uterus, breast and lung.
  • In majority of PJS cases, the germline mutations in serine/threonine kinase STK11/LKB1 gene were found to be associated with disease.
  • Here we report the results of a first mutational screen of STK11/LKB1 in PJS patients characterized in Slovak population.
  • The first patient with unusual carcinoma of duodenum was a sporadic case and carried c.842delC change residing in a mutational C6 repeat hotspot.
  • Neither the polyp nor the tumor of the patient displayed the loss of heterozygosity at the site of mutation suggesting different mechanism involved in the formation of polyp and tumor in this case.
  • The second patient belonged to a three-generation family with typical PJS features but not cancers.
  • Interestingly, the patient displayed concomitant occurrence of adenomatous and hamartomatous polyps.
  • [MeSH-minor] Adult. DNA Mutational Analysis. Female. Genotype. Humans. Intestinal Polyps / pathology. Intestine, Small / pathology. Male. Pedigree. Phenotype. Slovakia

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  • (PMID = 17319781.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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23. Rocha Ramírez JL, Villanueva Sáenz E, Hernández-Magro PM, Sierra Montenegro E, Soto Quirino R, Pérez Aguirre J, Blanco Lemus E: [Hereditary mixed polyposis syndrome. First report in Mexico]. Rev Gastroenterol Mex; 2005 Oct-Dec;70(4):430-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Síndrome de poliposis mixta hereditaria. Primer reporte en México.
  • BACKGROUND: The hereditary mixed polyposis syndrome (HMPS) is an uncommon condition, distinguished by presence of a different histological pattern of polyps in digestive tract, clinically manifested by diarrhea, anemia and weight loss.
  • CASE REPORT: Male patient, 38 years old, with familiar antecedent (dead sister) with polyps and gastric cancer.
  • With history of a 1 year with bleeding and mucous diarrhea, and weight loss of a 28.6 pounds.
  • At blood test with hemoglobin of 9.7 g/dL, and colonoscopy with multiple polyps within colon and rectum, upper endoscopy with a big esophageal polyp and multiple polyps in gastric and duodenal lining smaller than 1 cm.
  • Histopathologic study of the polyps report mixed pattern of polyps: (hyperplasic-adenomatous, juvenile-adenomatous, adenoma-inflammatory-hyperplasic, hyperplasic-adenomatous with a high degree dysplasia); juvenile in esophagus, and hyperplasic in stomach and duodenum.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis

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  • (PMID = 17058983.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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24. Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C: Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers. Gastroenterology; 2010 Dec;139(6):1927-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers.
  • Case reports found 35%-85% of CS patients had gastrointestinal (GI) hamartomas.
  • The association of benign and malignant GI neoplasias with CS remains debatable.
  • Our goal is to describe the GI phenotype in a prospective series of PTEN mutation carriers.
  • METHODS: Patients who met relaxed International Cowden Consortium criteria (N = 2548) or with 5 or more GI polyps, 1 or more of which was hyperplastic or hamartomatous (N = 397), were prospectively recruited.
  • RESULTS: Of 127 PTEN mutation carriers, 69 underwent 1 or more endoscopies with 64 (93%) having polyps.
  • Of the 64, half had hyperplastic polyps.
  • There were one to innumerable polyps in the colorectum, ileum, duodenum, stomach, and/or esophagus, with 24 subjects having both upper and lower GI polyps.
  • Nine (13%) subjects had colorectal cancer, all younger than the age of 50.
  • CONCLUSIONS: PTEN-associated CS should be considered a mixed polyp syndrome, with hyperplastic polyps most prevalent, with a risk of early onset colorectal cancer.
  • Routine colonoscopy should be considered in PTEN-associated CS, especially in the context of hyperplastic and/or adenomatous polyps.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20600018.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA124570; United States / NCI NIH HHS / CA / P01CA124570
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS466893; NLM/ PMC3652614
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25. Pârlog G, Murărescu D, Ungureanu C, Danciu M, Mihailovici MS: [Histopathologic and immunohistochemic changes in Helicobacter pylori colonised gastric mucosa]. Rev Med Chir Soc Med Nat Iasi; 2010 Jul-Sep;114(3):813-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Histopathologic and immunohistochemic changes in Helicobacter pylori colonised gastric mucosa].
  • [Transliterated title] Modificările histopatologice şi imunohistochimice din mucoasa gastrică colonizată de Helicobacter pylori.
  • Helicobacter pylori (H. pylori) colonize gastric mucosa causing both inflammatory changes, premalignant lesions and malignant tumors, including gastric lymphoma and carcinoma.
  • In this study, our propose was to evaluate the histopathological changes corellated with immunohistochemical results demonstrating the types of cellular infiltration and proliferative activity of gastric mucosa infected with H. pylori.
  • MATERIAL AND METHOD: Gastric endoscopic examinations was performed in 468 patients with anti-H. pylori antibodies and dispeptic phenomena.
  • Snippets harvested endobiopsic stomach were fixed in formalin and processed by paraffine inclusion.
  • In 65 cases of endobiopsic fragments (36 deep chronic gastritis with intestinal metaplasia, glandular atrophy and intraepithelial neoplasia and 29 carcinomas) immunohistochemical reactions were performed by applying reagents for evidence of H. pylori colonies, of T lymphocytes (CD3) and macrophages (CD68) and Ki-67 reagent for proliferating nuclear antigen labelling.
  • Histologically, were diagnosed : 463 superficial and deep chronic gastritis associated with premalignant lesions, 29 carcinomas, 2 non-Hodgkin's lymphoma and an adematous polyp.
  • Foveolar cell nuclei, in areas of intraepithelial neoplasia and carcinomatous cells were intensely stained with Ki-67, demonstrating increased proliferation.
  • CONCLUSIONS: In gastric infection with H. pylori, inflammatory infiltrat is composed of abundant macrophages and T lymphocytes.
  • Ki-67 was absent or minimal in chronic gastritis, while in areas of intraepithelial neoplasia was positive in both foveolar and coating epithelium. Anti-H. pylori antibodies in human serum remains one of the simplest methods to detect H. pylori, therefore it plays an important role in practice.
  • Medical eradication of bacteria may cancel inflammatory changes, metaplasia and proliferation of gastric mucosa and thus it prevents the cascade of carcinogenesis.
  • [MeSH-major] Gastric Mucosa / microbiology. Gastric Mucosa / pathology. Helicobacter Infections / pathology. Helicobacter pylori
  • [MeSH-minor] Adenomatous Polyps / microbiology. Adenomatous Polyps / pathology. Biopsy. Carcinoma / microbiology. Carcinoma / pathology. Cohort Studies. Female. Gastritis / microbiology. Gastritis / pathology. Gastroscopy. Humans. Immunohistochemistry. Lymphoma / microbiology. Lymphoma / pathology. Male. Middle Aged. Stomach Neoplasms / microbiology. Stomach Neoplasms / pathology

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  • (PMID = 21243808.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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26. Vakhrushev IaM, Kniazeva BG: [The peculiarities of the contents of the gastric mucus in patients with gastric polyps]. Klin Med (Mosk); 2007;85(4):49-52
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  • [Title] [The peculiarities of the contents of the gastric mucus in patients with gastric polyps].
  • Complex study of the components of the gastric mucus in 60 patients with gastric polyps was studied.
  • The study found significant changes in the protein-hydrocarbonate composition of the gastric mucus, manifesting by an increased concentration of free, oligo-combined and protein-combined sialic acids and glycosaminoglycans.
  • The degree of the changes in the gastric mucus was higher in patients with adenomatous polyps vs. hyperplastic ones.
  • Hormonal factors play an important role in the disintegration of the gastric mucus.
  • [MeSH-major] Gastric Mucosa / pathology. Mucus. Polyps / pathology. Stomach Diseases / pathology

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  • (PMID = 17564039.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Glycosaminoglycans
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27. Komarov FI, Osadchuk AM, Osadchuk MA, Kogan NIu, Kveshnoĭ IM: [Specifics of apoptotic activity and expression of regulatory molecules (Ki-67, Bcl-2) of gastric mucosal epitheliocytes, in the process of Correa's cascade]. Klin Med (Mosk); 2007;85(10):48-51
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  • [Title] [Specifics of apoptotic activity and expression of regulatory molecules (Ki-67, Bcl-2) of gastric mucosal epitheliocytes, in the process of Correa's cascade].
  • The subjects of the study were 104 patients with Helicobacter pylori (HP)-associated gastric pathology, including 30 patients with gastric ulcer (GU), 30 patients with chronic atrophic gastritis (CAG), 20 patients with CAG plus adenomatous polyps (AP), and 24 patients with gastric cancer (GC).
  • The study revealed that GU, CAG, AP, and GC were consequent stages of gastric mucosal epithelial cell regeneration disorder which manifested by the fact that the apoptotic activity of these cells was lower than their proliferation rate, and this difference grew with time; the reflection of this was the growth of Ki-67 and Bcl-2 expression.
  • Epithelial cell apoptosis/proliferation ratio tended to normalize, which suggests that the processes of mucosal atrophy and metaplasia, and initial signs of gastric mucosal dysplasia in patients with HP-associated pathology may be reversible.
  • [MeSH-major] Apoptosis. Cell Transformation, Neoplastic. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Helicobacter Infections / metabolism. Helicobacter pylori. Ki-67 Antigen / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Stomach Diseases / metabolism
  • [MeSH-minor] Adenomatous Polyps / metabolism. Adult. Aged. Anti-Infective Agents / therapeutic use. Atrophy / metabolism. Cell Proliferation. Epithelial Cells / metabolism. Female. Gastritis, Atrophic / metabolism. Gene Expression Regulation, Neoplastic. Humans. Male. Metaplasia / metabolism. Middle Aged. Regeneration. Stomach Ulcer / metabolism

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  • (PMID = 18154181.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2
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28. Parés D, García-Ruiz A, Biondo S, Blanco I, Llort G, Arriol E, de Oca J, del Río C, Osorio A, Navarro M, Martí-Ragué J, Jaurrieta E: [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis]. Gastroenterol Hepatol; 2006 Jan;29(1):15-20
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  • [Title] [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis].
  • [Transliterated title] Estado actual del seguimiento del área gastroduodenal en la poliposis adenomatosa familiar.
  • Familiar adenomatous polyposis (FAP) is a hereditary disease characterized by the development of multiple adenomatous polyps in the gastrointestinal tract and colorectal cancer in practically all patients who do not receive appropriate treatment.
  • Although the most commonly involved region in this disease is the colorectal area, it is well known that adenomas can also develop in the upper gastrointestinal tract, mainly in the periampullary area of the duodenum.
  • Because of the possibility of malignant transformation of these polyps, adequate monitoring is required, even though the optimal follow-up schedule has not yet been defined.
  • In the present article, we report a case of a gastric adenocarcinoma detected during the follow-up of a patient diagnosed with FAP, as well as a review of the literature on this subject.
  • We stress the need for early detection and appropriate management of this disease.
  • Sufficient information is available to support the use of upper gastrointestinal endoscopy with lateral vision and serial biopsies of the periampullary region in these patients.
  • The first endoscopy in patients with FAP should be performed at the age of 20 years or at diagnosis.
  • Subsequently, a follow-up schedule should be designed, according to the number and histological characteristics of the polyps observed.
  • [MeSH-major] Adenocarcinoma / etiology. Adenomatous Polyposis Coli / complications. Stomach Neoplasms / etiology
  • [MeSH-minor] Adult. Endoscopy, Gastrointestinal. Female. Humans

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  • (PMID = 16393625.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 34
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29. Stănciulea O, Preda C, Herlea V, Popa M, Ulmeanu D, Vasilescu C: [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis]. Chirurgia (Bucur); 2007 Mar-Apr;102(2):215-20
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  • [Title] [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis].
  • [Transliterated title] Indicaţie rară de duodenopancreatectomie cefalică cu gastrectomie totală-- adenocarcinom periampular cu polipoză adenomatoasă familială forma atenuată.
  • We present the case of a 52 years old man, with significant familial history, diagnosed with familial adenomatous polyposis-attenuated form, with no clinical and endoscopic surveillance until 2001 when he was admitted for an upper gastrointestinal haemorrhage episode.
  • Upper gastrointestinal scopy revealed duodenal adenomatous polyps and gastric hyperplastic polyps.
  • The histopathological exam revealed duodenal G2 adenocarcinoma pT3N0, and gastric hyperplastic polyps with no signs of dysplasia.
  • The surgical procedure was followed by chemotherapy.
  • In 2002 the patient was admitted for rectal bleeding and colonoscopy showed 2 sigmoid polyps, appropriate for endoscopic removal and a poly-lobate polyp in the transverse colon.
  • The patient underwent transverse colectomy (the histopathological exam--in situ carcinoma).
  • March 2003--the patient underwent endoscopic removal for a rectal polyp (histopathological exam: moderate dysplasia).
  • The surgical procedure recommended in patients with attenuated form of familial adenomatous polyposis and suspect periampullary lesions is duodenopancreatectomy.
  • The particularity of the case is the association of total gastrectomy for gastric hyperplastic polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Carcinoma / surgery. Duodenal Neoplasms / surgery. Gastrectomy. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Ampulla of Vater. Humans. Male. Middle Aged. Stomach Neoplasms / surgery. Treatment Outcome

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  • (PMID = 17615925.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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30. Joo MK, Park JJ, Lee WW, Lee BJ, Hwang JK, Kim SH, Jung W, Kim JH, Yeon JE, Kim JS, Byun KS, Bak YT: Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals. Endoscopy; 2010 Feb;42(2):114-20
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  • [Title] Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals.
  • BACKGROUND AND AIMS: We compared the prevalence of adenomatous and cancerous colon polyps in patients who underwent endoscopic removal of gastric neoplasms and in healthy controls.
  • MATERIALS AND METHODS: This retrospective study reviewed the medical records of 186 patients with gastric neoplasms and 186 healthy subjects from January 2002 to October 2008.
  • The gastric neoplasm group was comprised of patients undergoing endoscopic removal of gastric adenomas or early gastric cancers and serial fiberoptic colonoscopy (FCS) for checkups.
  • The control group was comprised of subjects undergoing fiberoptic esophagogastroduodenoscopy (FEGD) and FCS for general checkup and was matched for age and sex with the gastric neoplasm group.
  • Advanced colonic neoplasm was defined by any of the following:.
  • (1) the presence of three or more polyps;.
  • (2) polyp size at least 1.0 cm;.
  • RESULTS: Of the 372 persons, colorectal polyps were detected in 124 (33.3 %), advanced colonic neoplasms in 44 (11.8 %), and adenocarcinomas in 10 (2.7 %).
  • The overall prevalence of adenomatous or cancerous polyps ("all polyps") and the prevalence of advanced colonic neoplasms were significantly higher in the gastric neoplasm group than in the control group (all polyps: 40.9 % in the gastric neoplasm group vs. 25.8 % in the control group, P = 0.002; advanced colonic neoplasms: 15.6 % vs. 8.1 %, P = 0.025).
  • The risk factors for all polyps were age, male sex, diabetes mellitus, and being assigned to the gastric neoplasm group, and those for advanced colonic neoplasms were age and being assigned to the gastric neoplasm group.
  • Confining the analysis to the gastric neoplasm group, the risk factors for all polyps were identical with those for the total group; however, those for advanced colonic neoplasm were different (age vs. diabetes and hypertriglyceridemia).
  • CONCLUSION: Endoscopists should consider performing routine FCS in patients undergoing endoscopic removal of gastric neoplasms.
  • [MeSH-major] Adenoma / surgery. Colonic Polyps / epidemiology. Gastrectomy / methods. Gastroscopy / methods. Stomach Neoplasms / surgery
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Korea / epidemiology. Male. Middle Aged. Neoplasm Staging. Prevalence. Retrospective Studies

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20140828.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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31. Kobak AC, Zeybel M, Ayhan S, Aydin A, Kaya Y, Ellidokuz E: Gastric polypoid intramucosal carcinoma and an adjacently located leiomyoma at the cardia. Turk J Gastroenterol; 2008 Jun;19(2):114-6
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  • [Title] Gastric polypoid intramucosal carcinoma and an adjacently located leiomyoma at the cardia.
  • We report a 65-year-old patient with a gastric polyp of 2.5 cm in diameter located at the cardia on upper gastrointestinal (GI) endoscopy.
  • Pathological examination of the excised polyp showed intramucosal carcinoma.
  • Endoscopic ultrasonography (EUS) reported the lesion as early gastric carcinoma with probable submucosal involvement.
  • On serial sections of the gastrectomy material, the lesion was an intramucosal carcinoma and surprisingly there was a leiomyoma located adjacently.
  • [MeSH-major] Carcinoma / diagnosis. Gastric Mucosa / pathology. Leiomyoma / diagnosis. Neoplasms, Second Primary / diagnosis. Polyps / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Aged. Cardia / pathology. Cardia / surgery. Diagnosis, Differential. Endoscopy, Digestive System / methods. Endosonography. Female. Gastrectomy. Humans

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  • (PMID = 19110667.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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32. Lam-Himlin D, Park JY, Cornish TC, Shi C, Montgomery E: Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol; 2010 Nov;34(11):1656-62
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  • [Title] Morphologic characterization of syndromic gastric polyps.
  • The morphology of gastric hamartomatous polyps from patients with juvenile polyposis syndrome (JuvPS) and Peutz-Jeghers' Syndrome (PJS) is poorly characterized.
  • We investigated the histologic features of gastric polyps in patients with established JuvPS or PJS to develop improved histologic criteria to distinguish these from gastric hyperplastic (HP) polyps.
  • All gastric polyps (n=30) from these patients were intermixed with gastric HP polyps from nonsyndromic patients (n=26) and subsequently blindly reviewed by a panel of gastrointestinal pathologists.
  • A consensus diagnosis was rendered.
  • The panel then reviewed the slides in the context of clinical data and identified histologic features for distinguishing JuvPS, PJS, and HP gastric polyps based on epithelial changes, pit architecture, lamina propria features, and smooth muscle qualities.
  • On initial review, accuracy in diagnosis of gastric polyps in JuvPS was 50% and was 18% in PJS compared with 92% for HP gastric polyps.
  • Adherence to the recommended histologic criteria resulted in diagnostic accuracy of 41% for JuvPS and 54% for PJS, compared with 73% for HP gastric polyps.
  • Accuracy in diagnosis in antral mucosa was 66%, oxyntic mucosa 71%, and transitional-type mucosa (mixed antral and oxyntic) 32%.
  • The diagnostic accuracy based on polyp size was 59% for polyps which were less than equal to 3 mm, 56% for those 4 to 9 mm, and 81% for polyps which were more than equal to 10 mm.
  • The identification of gastric polyps from JuvPS and PJS patients without the context of clinical history of these syndromes remains poor, even with adherence to a set of morphologic criteria.
  • Abiding by such criteria improved recognition of PJS polyps by more than double (P<0.19), but yielded an accuracy of only 54%.
  • The accuracy did not improve when results were stratified for polyp location but did with biopsy size which were more than equal to10 mm.
  • Whereas these syndromic polyps are readily diagnosed in the small bowel and colon, histologic features to distinguish gastric JuvPS and PJS from gastric HP polyps are unreliable.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Gastric Mucosa / pathology. Hamartoma Syndrome, Multiple / diagnosis. Peutz-Jeghers Syndrome / diagnosis. Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Baltimore. Biopsy. Diagnosis, Differential. Humans. Hyperplasia. Observer Variation. Reproducibility of Results

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  • (PMID = 20924281.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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33. Korstanje A, van Eeden S, Offerhaus JA, Waltman FL, Hartog Gd, Roelandse FW, Souverijn JH, Biemond I, Lamers CB: Comparison between serology and histology in the diagnosis of advanced gastric body atrophy: a study in a Dutch primary community. J Clin Gastroenterol; 2008 Jan;42(1):18-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison between serology and histology in the diagnosis of advanced gastric body atrophy: a study in a Dutch primary community.
  • GOALS: To assess serologically diagnosed gastric body atrophy (GBA) by histology in a sample of the general population.
  • BACKGROUND: GBA is a precursor lesion in gastric cancer.
  • Data on GBA in a primary health care community in the Netherlands have not been reported.
  • One subject with normal serum gastrin at retesting had both antral and body atrophy giving a concordance between serologic and histologic GBA of 95% (19/20).
  • No adenomatous polyps, tumors, or dysplastic alterations were found.
  • [MeSH-major] Gastritis, Atrophic / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Bacterial / blood. Atrophy / pathology. Autoantibodies / blood. Autoimmune Diseases / epidemiology. Biopsy. Chronic Disease. Cohort Studies. Diagnosis, Differential. Endoscopy. Female. Gastric Fundus / pathology. Gastrins / blood. Helicobacter Infections / epidemiology. Helicobacter pylori / immunology. Humans. Male. Middle Aged. Netherlands / epidemiology. Pepsinogens / blood. Prevalence. Pyloric Antrum / pathology. Serologic Tests

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  • (PMID = 18097284.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Autoantibodies; 0 / Gastrins; 0 / Pepsinogens
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34. Osadchuk AM, Osadchuk MA, Kvetnoĭ IM: [The role of some cell regeneration markers of epithelial cells in genesis of gastric tumors associated with H. pylori]. Klin Med (Mosk); 2008;86(5):33-8
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  • [Title] [The role of some cell regeneration markers of epithelial cells in genesis of gastric tumors associated with H. pylori].
  • It is established, that chronic atrophic gastritis adenomatous polyps and gastric cancer are consecutive stages of gastric mucous tunic cell renovation disturbance, manifests itself in progressive delay its apoptosis activity from proliferation, which reflects increase in expression Ki-67 and Bcl-2.
  • Eradication of Helicobacter pylori shorts activity and reduces intensity of inflammatory process in gastric mucous tunic and improves indices of cell renovation.
  • [MeSH-major] Apoptosis / physiology. Cell Proliferation. Gastric Mucosa / pathology. Gastritis, Atrophic / complications. Helicobacter Infections / complications. Helicobacter pylori / isolation & purification. Stomach Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / biosynthesis. Biopsy. Disease Progression. Epithelial Cells / metabolism. Epithelial Cells / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / biosynthesis. Precancerous Conditions. Proto-Oncogene Proteins c-bcl-2 / biosynthesis

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  • (PMID = 18589715.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2
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35. Schulmann K, Pox C, Tannapfel A, Schmiegel W: The patient with multiple intestinal polyps. Best Pract Res Clin Gastroenterol; 2007;21(3):409-26

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  • [Title] The patient with multiple intestinal polyps.
  • The management of patients with multiple intestinal polyps may be difficult and greatly depends on the correct classification.
  • In addition the risk for extracolonic cancer is increased in most syndromes.
  • Here we report the case of a difficult patient with severe gastric polyposis and we present a review of polyposis syndromes such as classical and attenuated familial adenomatous polyposis (FAP), MYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis as well as rare polyposis syndromes.
  • The most practical approach for the diagnostic workup in patients with newly diagnosed gastrointestinal polyposis is based on the histological typing of polyps.
  • In addition, a detailed family history regarding cancer, polyps and congenital abnormalities should be obtained from every polyposis patient.
  • Of these, younger age and higher polyp count are most likely a diagnosis of typical FAP.
  • Older age and fewer polyps favour a diagnosis of AFAP or MAP.
  • Germline testing of the APC gene is suggested, and if negative, MYH gene testing should be done.
  • For diagnostic and therapeutic problems a familial colorectal cancer center should be consulted.
  • [MeSH-major] Intestinal Polyps / diagnosis

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  • (PMID = 17544108.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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36. Bianchi LK, Burke CA, Bennett AE, Lopez R, Hasson H, Church JM: Fundic gland polyp dysplasia is common in familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2008 Feb;6(2):180-5
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  • [Title] Fundic gland polyp dysplasia is common in familial adenomatous polyposis.
  • BACKGROUND & AIMS: Fundic gland polyps (FGPs) are common in familial adenomatous polyposis (FAP) but have been considered nonneoplastic.
  • Gastric carcinoma arises from FGPs in FAP presumably from a dysplasia-carcinoma pathway.
  • H pylori infection was rare in subjects with vs without FGPs (1.5% vs 33.3%, P = .005).
  • In the multivariable analysis larger FGP size (odds ratio [OR], 4.0; 95% confidence interval [CI], 1.1-14.4), higher stage of duodenal polyposis (OR, 2.3; 95% CI, 1.2-4.5), and antral gastritis (OR, 11.2; 95% CI, 1.2-103.9) were associated with FGP dysplasia.
  • FGP dysplasia is associated with larger polyp size, increased severity of duodenal polyposis, and antral gastritis.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / pathology. Gastric Fundus / pathology. Precancerous Conditions / epidemiology. Precancerous Conditions / pathology. Pyloric Antrum / pathology. Stomach Neoplasms
  • [MeSH-minor] Adult. Biopsy. Duodenum / pathology. Endoscopy, Gastrointestinal. Female. Helicobacter pylori / isolation & purification. Humans. Male. Middle Aged. Prevalence

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  • (PMID = 18237868.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Brazowski E, Rozen P, Misonzhnick-Bedny F, Gitstein G: Characteristics of familial juvenile polyps expressing cyclooxygenase-2. Am J Gastroenterol; 2005 Jan;100(1):130-8
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  • [Title] Characteristics of familial juvenile polyps expressing cyclooxygenase-2.
  • OBJECTIVES: Familial juvenile polyposis (FJP) is a dominant genetic disorder characterized by colorectal, gastric, and small bowel juvenile polyps, and high risk for gastrointestinal cancer.
  • We determined the characteristics of FJP polyps expressing cyclooxygenase-2 (COX-2).
  • METHODS: A total of 115 colorectal and 6 gastric polyps were available from 17 FJP patients.
  • Comparison tissues were 18 sporadic juvenile colorectal polyps, 6 gastric hyperplastic polyps, 9 normal colons, and 3 colorectal cancers (CRCs).
  • The polyps' epithelium and stroma and comparison tissues were quantified for COX-2 by: area of staining (0-3) x intensity (0-3).
  • Epithelial and stromal scores (0-9) and total scores (0-18) were evaluated in relationship to patient's age, polyp site, size, dysplasia, and stromal cellularity.
  • RESULTS: Colonic FJP polyps mean total COX-2 score was 10.3 +/- 6.0, and that of sporadic juvenile polyps 3.6 +/- 2.2 (p < 0.01), and in contrast to the latter, FJP COX-2 scores increased significantly (p < 0.01) with polyp size.
  • Linear regression analysis showed significant associations of COX-2 in FJP polyps with dysplasia (p < 0.01), stromal cellularity (p < 0.01), size (> or =1.5 cm) (p= 0.02), and site (right colon) (p= 0.01), and not with age.
  • COX-2 total scores of gastric FJP polyps and hyperplastic polyps were similar.
  • CONCLUSIONS: Expression of COX-2 in FJP polyps and its association with size and dysplasia suggest that, in these patients, chemoprevention with selective COX-2 inhibitors might be a useful adjunct therapy to colonoscopic polypectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / enzymology. Colonic Polyps / enzymology. Isoenzymes / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism
  • [MeSH-minor] Adolescent. Adult. Child. Cyclooxygenase 2. Epithelial Cells / metabolism. Humans. Membrane Proteins. Stomach Neoplasms / enzymology. Stomach Neoplasms / etiology. Stomach Neoplasms / pathology. Stromal Cells / metabolism

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  • (PMID = 15654792.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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38. Regev M, Barzilai SE, Figer A, Zidan J, Fidder HH, Friedman E: The I1307K APC mutation in a high-risk clinic setting: a follow-up study. Clin Genet; 2005 Apr;67(4):352-5
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  • [Title] The I1307K APC mutation in a high-risk clinic setting: a follow-up study.
  • While the I1307K APC mutation clearly confers an increased lifetime risk for colorectal cancer, there is a paucity of data on the natural history of colonic neoplasia in symptomatic and asymptomatic mutation carriers.
  • In this study, 51 Jewish I1307K APC mutation carriers were identified in a high-risk familial cancer clinic over a 4-year period, of whom 29 (56.8%) (four males and 25 females) were successfully telephone interviewed for 0.5-5 years (mean 2.4 +/- 1.4) after initial genetic testing.
  • Of these 29 cases, one individual was diagnosed with colon cancer at the age of 45 years, five had adenomatous polyps (mean number of polyps = 1.8), 11 had breast cancer (mean age at diagnosis 49.5 +/- 10.5 years), and 12 were asymptomatic, at the time of the testing.
  • During the follow-up period, new colonic polyps were diagnosed in three mutation carriers, two with previously diagnosed colon cancer and polyps and only one of the asymptomatic mutation carriers, and two additional previously affected patients had new cancer diagnoses: gastric cancer and melanoma.
  • From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors.
  • [MeSH-major] Colorectal Neoplasms / genetics. Genes, APC. Point Mutation
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / genetics. Colonic Polyps / genetics. Female. Follow-Up Studies. Heterozygote. Humans. Israel. Male. Middle Aged. Retrospective Studies. Risk

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  • (PMID = 15733272.001).
  • [ISSN] 0009-9163
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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39. Zurac S, Micu G, Bastian A, Grămadă E, Lavric L, Andrei R, Stăniceanu F, Voiosu R, Croitoru A: Malignancy and overdiagnosis of malignancy in Peutz Jeghers polyposis. Rom J Intern Med; 2008;46(2):179-84
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  • [Title] Malignancy and overdiagnosis of malignancy in Peutz Jeghers polyposis.
  • Peutz Jeghers (PJ) polyps are rare hamartomatous tumors of the gastrointestinal tract frequently associated with skin and mucosal pigmentation.
  • Despite their benign nature there is a certain increased risk of progression to malignancy in some cases, justifying a sustained follow-up of the patients.
  • We present 3 cases of Peutz Jeghers syndrome (PJS) diagnosed in our hospital on gastrointestinal specimens obtained by endoscopy and opened surgery.
  • We analyzed different degrees of dysplastic changes, epithelial intussusception, association with other types of polypoid lesions and other various aspects possibly related with disease progression.
  • Two of these cases were related (mother and daughter); both of them were operated in another hospital for small bowel tumors with a subsequent diagnosis of adenocarcinoma.
  • The daughter (28 years old) was referred to our hospital for endoscopic follow-up; a small polyp of the transverse large bowel was excised by colonoscopy with a histopathologic diagnosis of PJ polyp; a careful histopathologic reevaluation of both specimens of enterectomy (slides and paraffin blocks) revealed an overdiagnosis of cancer due to the epithelial cystic dilatation and pseudoinvasion in both patients.
  • The other case showed diagnostic changes of PJS and also various aspects of adenomatous polyps some of them with mild and moderate dysplastic changes.
  • When a PJ polyp is diagnosed, the possibility of pseudoinvasion should be kept in mind, in order to avoid overdiagnosis of malignancy; also, due to the fact that the malignant transformation of a PJ polyp is still on debate (hamartoma-dysplasia-carcinoma sequence versus malignant transformation of an adenomatous aria of a hamartoma versus coincidental association of a digestive cancer due to genetic aberrations of PJS), all the other associated microscopic aspects of the lesion should be carefully analyzed.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Intestinal Neoplasms / pathology. Intestinal Polyps / pathology. Peutz-Jeghers Syndrome / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 19284092.001).
  • [ISSN] 1220-4749
  • [Journal-full-title] Romanian journal of internal medicine = Revue roumaine de médecine interne
  • [ISO-abbreviation] Rom J Intern Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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40. Farah Klibi F, Ferchichi L, Borgi C, Jemaa Y, Najjar T, Ben Jilani S, Zermani R: [Histopathological study of gastric polyps. A report of 65 cases]. Tunis Med; 2006 Oct;84(10):611-6
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  • [Title] [Histopathological study of gastric polyps. A report of 65 cases].
  • [Transliterated title] Etude anatomo-pathologique des polypes gastriques. A propos de 65 cas.
  • In a retrospective study of the specimens of gastric polypectomy, carried out between January 1992 and December 2002, we analysed the demographic and histological aspects of 65 polyps.
  • This study revealed hyperplastic polyps in 66%, adenomatous lesions in 9.2%, Peutz-Jeghers polyps in 7.7%, inflammatory fibroid polyps in 6.15%, two cases of focal foveolar hyperplasia (3%), two cases of Brunner's gland heterotopia (3%), 1 pancreatic heterotopia (1.5%), 1 fundic gland polyp (1.5%) and 1 carcinoid tumor (1.5%).
  • All adenomas and two Peutz-Jeghers polyps include intraepithelial neoplasia.
  • Moreover, we identified a case of Brunner's gland heterotopia, which contain a focus of plane tubular adenoma with high-grade intraepithelial neoplasia.
  • Other lesions were found within the polyps or into the surrounding gastric mucosa, such as intestinal metaplasia and Helicobacter Pylori gastritis.
  • This work allowed us to recommend complete removal of gastric polyps and the realization of biopsies of the nonpolypoid gastric mucosa in the search of intraepithelial neoplasia or other lesions with malignant potential.
  • [MeSH-major] Adenomatous Polyps / pathology. Carcinoid Tumor / pathology. Cell Transformation, Neoplastic / pathology. Peutz-Jeghers Syndrome / pathology. Polyps / pathology. Stomach / pathology. Stomach Diseases / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brunner Glands. Choristoma / pathology. Gastric Mucosa / pathology. Gastritis / pathology. Gastritis / virology. Helicobacter Infections / pathology. Helicobacter pylori. Humans. Hyperplasia / pathology. Middle Aged. Pancreas. Retrospective Studies

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  • (PMID = 17193851.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Tunisia
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41. Freeman HJ: Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction. World J Gastroenterol; 2005 Sep 7;11(33):5245-7
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  • [Title] Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction.
  • Endoscopy showed a large polyp on a stalk, protruding through the pylorus into the duodenum causing intermittent gastric outlet obstruction.
  • While prolapsing gastric antral polyps are usually benign and hyperplastic, inflammatory or regenerative in type, excisional snare polypectomy here led to complete resolution of his symptoms, but showed a malignant polyp.
  • [MeSH-major] Adenomatous Polyps / complications. Adenomatous Polyps / surgery. Gastric Outlet Obstruction / etiology. Gastroscopy. Stomach Neoplasms / complications. Stomach Neoplasms / surgery
  • [MeSH-minor] Aged. Carcinoma / pathology. Humans. Male

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  • (PMID = 16127764.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320407
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42. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA: Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol; 2007 Jan-Mar;44(1):14-7
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  • [Title] Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies.
  • BACKGROUND: Gastric polyps are small gastric lesions, asymptomatic in most cases and are generally discovered inadvertently during upper digestive endoscopy.
  • AIM: To retrospectively review the characteristics and frequency of gastric polyps, derived from the gastric mucosal epithelium in a large series of endoscopies.
  • METHODS: One hundred and fifty three patients in a series of 26,000 consecutive upper digestive endoscopies done over a 5-year period, being that each patient had only one examination were analyzed and their histological and Yamada classification, as well as their location, size, histopathological findings and treatment studied.
  • All patients had at least one gastric polyp, as confirmed by histological examination.
  • RESULTS: The polyps were classified as hyperplastic, adenomatous and fundic gland polyps.
  • The most of them measure less than 1 cm (hyperplastic polyps - 60,5%; adenomatous polyps - 73,6%; fundic gland polyps - 72%).
  • Hyperplastic polyps were the most frequent and accounted for 71.3% of the cases, whereas fundic gland polyps accounted for 16.3% and adenomatous polyps for 12.4%.
  • Hyperplastic and adenomatous polyps were primarily single, whereas fundic gland polyps tended to be multiple.
  • A carcinoma was detected in one hyperplastic polyp (0.9%) and in two adenomatous polyps (10.5%).
  • High grade dysplastic foci were found in four adenomatous polyps (21%).
  • CONCLUSIONS: The digestive endoscopy is the safest and efficient method for the diagnosis of the gastric polyps, that in most of the patients does not show characteristic symptoms.
  • The histopathological definition is not possible to the endoscopic glance being needed the pathologist's aid, once the conduct to be adopted will depend on the result of the biopsy.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Adult. Aged. Aged, 80 and over. Female. Gastric Fundus. Gastroscopy. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 17639176.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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43. Liu YH, Lin J, Guo J, You ZJ, Wang ZG, Zhong D, Yang XL, Zhang ZS, Xiao B, Guo WY: [Detection of interferon-induced transmembrane-1 gene expression for clinical diagnosis of colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Nov;28(11):1950-3
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  • [Title] [Detection of interferon-induced transmembrane-1 gene expression for clinical diagnosis of colorectal cancer].
  • OBJECTIVE: To investigate the expression of the interferon-induced transmembrane-1 (IFITM1) gene in colorectal cancer (CRC) tissue and the serum anti-IFITM1 antibody responses of the patients and assess their value in clinical diagnosis of CRC.
  • METHODS: Semi-quantitative RT-PCR was performed to detect IFITM1 mRNA expression in the specimens of normal colonic mucosa, CRC tissue, inflammatory polyps, adenomatous polyps, gastric cancer, esophageal carcinoma and liver cancer tissues.
  • The clinicopathological features of the carcinoma expressing IFITM1 gene were analyzed.
  • RESULTS: IFITM1 mRNA was expressed in 47.4 % (18/38) of the CRC specimens, a rate significantly higher than that in adenomatous polyps [15% (3/20)] and gastric cancer [4.8% (1/21)]; no obvious IFITM1 expression was found in normal colonic mucosa, inflammatory polyp, esophageal carcinoma or liver cancer tissues (P<0.001 or P<0.05).
  • IFITM1 mRNA was strongly expressed in CRC at the expression level of 0.8048-/+0.2273, which was significantly higher than that in adenomatous polyps (0.4447-/+0.0989, P<0.001).
  • No anti-IFITM1 antibody response was detected in healthy human sera, but in the CRC patients, the serum antibody response was detected at the rate of 36.8% (14/38), significantly higher than the rate of 9.5% (2/21) in gastric cancer (P<0.05).
  • No antibody response was detected in esophageal carcinoma, liver cancer, inflammatory polyp or adenomatous polyps.
  • Most of the IFITM1-expressing CRC had a diameter exceeding 5 cm, often invading the serous membrane with metastasis to the lymph nodes and the distant organs; these tumors were identified mostly as well-differentiated adenocarcinoma in Dukes stage C or D.
  • CONCLUSION: IFITM1 gene may play an important role in the pathogenesis, development and metastasis of CRC, and may serve as a potential biomarker for clinical diagnosis of CRC.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / genetics. Membrane Proteins / metabolism
  • [MeSH-minor] Antibodies / blood. Antigens, Differentiation. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Humans. RNA, Messenger / genetics. RNA, Messenger / immunology. RNA, Messenger / metabolism

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  • (PMID = 19033100.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Differentiation; 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / leu-13 antigen
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44. Tao H, Shinmura K, Yamada H, Maekawa M, Osawa S, Takayanagi Y, Okamoto K, Terai T, Mori H, Nakamura T, Sugimura H: Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis. BMC Res Notes; 2010;3:305

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  • [Title] Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis.
  • BACKGROUND: Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary disease characterized by multiple colorectal adenomatous polyps and frequent extracolonic manifestations.
  • An attenuated form of FAP (AFAP) is diagnosed based on a milder colorectal phenotype, and the colorectal phenotype of (A)FAP has been linked to germline APC mutations.
  • FINDINGS: Nine germline APC mutations, but no large deletions, were identified in the APC locus of 8 (A)FAP patients, and 5 of the mutations, c.446A > T (p.Asp149Val), c.448A > T (p.Lys150X), c.454_457insAGAA (p.Glu152ArgfsX17), c.497insA (p.Thr166AsnfsX2), and c.1958G > C (p.Arg653Ser), were novel mutations.
  • In one patient the p.Asp149Val mutation and p.Lys150X mutation were detected in the same APC allele.
  • The c.1958G > C mutation was located in the last nucleotide of exon 14, and RT-PCR analysis revealed that the mutation resulted in abnormal splicing.
  • (1) multiple gastroduodenal adenomas and early-onset gastric carcinoma in AFAP patients with an exon 4 mutation;.
  • (2) a desmoid tumor in two FAP patients with a germline APC mutation outside the region between codons 1403 and 1578, which was previously reported to be associated with the development of desmoid tumors in FAP patients;.
  • CONCLUSIONS: Nine germline APC mutations, 5 of them were novel, were identified in 8 Japanese (A)FAP patients, and some associations between germline APC mutations and extracolonic manifestations were demonstrated.

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  • (PMID = 21078199.001).
  • [ISSN] 1756-0500
  • [Journal-full-title] BMC research notes
  • [ISO-abbreviation] BMC Res Notes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2994888
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45. Goldstein NS: Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol; 2006 Jan;125(1):132-45
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  • [Title] Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases.
  • Eight sessile serrated adenoma (SSA), right colon polypectomies with focal invasive adenocarcinoma or high-grade dysplasia were studied to identify features indicating a high risk of transformation and characterize the morphologic features of serrated dysplasia; 6 cases had invasive adenocarcinoma; 2 were high-grade dysplasia.
  • The mean patient age at polypectomy was 69.5 years (range, 57.1-83.9 years).
  • Mean polyp maximum dimension was 8.5 mm (range, 6-12 mm).
  • The majority of each polyp was nonmalignant SSA.
  • All 8 cases had an abrupt transition from benign to high-grade in situ or invasive malignancy.
  • In the 6 invasive adenocarcinomas, the neoplasm extended directly down into the submucosa without lateral intramucosal spread.
  • Crypts adjacent to malignancy had moderately enlarged nuclei, irregular nuclear membranes, and overly prominent nucleoli.
  • SSA crypts were lined by a variety of gastric-type cells; no cell type predominated.
  • Small proximal SSAs can transform into adenocarcinoma without a component of adenomatous dysplasia.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Chromosomal Instability. Colonic Neoplasms / pathology. Microsatellite Repeats
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Aged. Aged, 80 and over. Carrier Proteins / analysis. Cell Transformation, Neoplastic / pathology. Colonic Polyps / pathology. Epithelium / pathology. Humans. Middle Aged. Nuclear Proteins / analysis

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  • (PMID = 16483002.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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46. Al-Thihli K, Palma L, Marcus V, Cesari M, Kushner YB, Barkun A, Foulkes WD: A case of Cowden's syndrome presenting with gastric carcinomas and gastrointestinal polyposis. Nat Clin Pract Gastroenterol Hepatol; 2009 Mar;6(3):184-9
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  • [Title] A case of Cowden's syndrome presenting with gastric carcinomas and gastrointestinal polyposis.
  • BACKGROUND: A 73-year-old white man was referred to a cancer genetics clinic for evaluation of a approximately 20-year history of mixed upper and lower gastrointestinal polyposis, including hyperplastic, inflammatory and adenomatous polyps, colonic ganglioneuromas, and associated diffuse, esophageal glycogenic acanthosis.
  • Two synchronous gastric carcinomas had been identified before referral and the patient had undergone a total gastrectomy, omentectomy and cholecystectomy.
  • Multiple hyperplastic polyps and small, sessile polyps were also observed in the gastrectomy specimen.
  • INVESTIGATIONS: History and physical examination, upper and lower gastrointestinal endoscopy and biopsy, genetic testing, molecular pathology investigations (immunohistochemistry), thyroid ultrasonography, fine-needle aspiration of a thyroid nodule.
  • DIAGNOSIS: Cowden's syndrome.
  • [MeSH-major] Carcinoma / etiology. Gastrointestinal Diseases / etiology. Hamartoma Syndrome, Multiple / complications. Polyps / etiology. Stomach Neoplasms / etiology
  • [MeSH-minor] Aged. Biopsy, Needle. Endoscopy, Gastrointestinal. Genetic Counseling. Genetic Techniques. Humans. Immunohistochemistry. Male. Thyroid Gland / ultrasonography. Thyroidectomy. Vitamin B 12 / therapeutic use

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  • (PMID = 19190598.001).
  • [ISSN] 1743-4386
  • [Journal-full-title] Nature clinical practice. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Clin Pract Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] P6YC3EG204 / Vitamin B 12
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47. Oh SY, Park DI, Yoo TW, Kang MS, Kim SH, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Son BH, Yoo CH: [Is gastric cancer a new indication for surveillance colonoscopy? Colon cancer is increased in gastric cancer patients]. Korean J Gastroenterol; 2006 Mar;47(3):191-7
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  • [Title] [Is gastric cancer a new indication for surveillance colonoscopy? Colon cancer is increased in gastric cancer patients].
  • BACKGROUND/AIMS: It has been reported that the risk of gastric polyp is increased in various colonic polyposis syndromes or in series of patients with sporadic colonic polyps.
  • However, there are only a few large case controlled studies of colon cancer incidence in gastric cancer patients who underwent colonoscopy.
  • The aims of this study were to determine the incidence of colorectal neoplasm and to evaluate the necessity of colonoscopic surveillance in patients with gastric cancer.
  • METHODS: We performed colonoscopy in 105 patients with gastric cancer who agreed to undergo colonoscopy before or after 6 months from gastric resection between January 2002 and December 2004 in Kangbuk Samsung hospital.
  • As a control group, 269 consecutive, age and sex matched patients without gastric neoplasm on gastroscopy who underwent colonoscopy within 6 months for the evaluation of various gastrointestinal symptoms during the year 2004 were included.
  • RESULTS: In the patient group, adenomatous polyps were diagnosed in 24/105 patients (22.9%) and colorectal adenocarcinoma in 10/105 patients (9.5%).
  • In the control group, adenomatous polyps were diagnosed in 78/269 patients (29.0%) and colorectal adenocarcinoma in 2/269 patients (0.7%).
  • CONCLUSIONS: The risk of colorectal adenocarcinoma increases significantly in patients with gastric cancer.
  • We suggest that the patients with gastric cancer might carry a high risk for colorectal cancer whom require surveillance colonoscopy.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 16554672.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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48. Bouguen G, Manfredi S, Blayau M, Dugast C, Buecher B, Bonneau D, Siproudhis L, David V, Bretagne JF: Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics. Dis Colon Rectum; 2007 Oct;50(10):1612-7

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  • [Title] Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics.
  • PURPOSE: Recent literature reports that several digestive diseases are associated with mutations in the base excision repair gene MYH.
  • This study was designed to establish the prevalence of germ-line MYH mutations in a series of 56 consecutive patients with no detectable APC mutation and describe the phenotype of those with MYH mutations.
  • RESULTS: MYH mutations were identified only in the group of patients with attenuated adenomatous polyposis with ten or more adenomatous polyps.
  • Three patients presented with a family history of adenomatous polyposis in siblings, without vertical transmission.
  • The median number of colorectal adenomatous polyps was 53 without preferential localization.
  • Colorectal cancer was associated with polyposis in seven patients.
  • Gastric and duodenal adenomas were diagnosed in one case.
  • The phenotype of the disease is similar to attenuated familial adenomatous polyposis.
  • Upper gastrointestinal endoscopy also should be recommended.
  • However, its transmission shows evidence of a recessive pattern.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. DNA Glycosylases / genetics. Mutation / genetics
  • [MeSH-minor] Adult. Aged. Female. Genes, APC. Genotype. Humans. Male. Middle Aged. Phenotype. Polymerase Chain Reaction

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  • (PMID = 17674103.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases
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49. Smith GV, Feakins R, Farthing MJ, Ballinger A: Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. Am J Clin Pathol; 2005 Mar;123(3):415-20
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  • [Title] Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps.
  • Gastric adenomatous polyps are rare findings in upper gastrointestinal endoscopy; however, they are associated strongly with malignant transformation.
  • Few series describe the oncogenic characteristics of gastric adenomas.
  • In the present study, we immunohisto-chemically assessed the expression of cyclooxygenase (COX)-2, beta-catenin, p53, and adenomatous polyposis coli (APC) in paraffin-embedded specimens of 14 gastric adenomas.
  • Control samples of normal gastric tissue and gastric adenocarcinoma also were analyzed.
  • Similar alterations in oncoprotein expression were seen in gastric cancers but not in normal control sections.
  • Gastric adenomas display alterations in the expression of COX-2, beta-catenin, and APC similar to those seen in adenocarcinomas; however, accumulation of p53 was significantly more common in adenomas than in cancers.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Adenomatous Polyps / metabolism. Cytoskeletal Proteins / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism. Stomach Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cyclooxygenase 2. Humans. Membrane Proteins. Neoplasm Proteins / metabolism. beta Catenin

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  • (PMID = 15716238.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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50. Leal RF, Ayrizono Mde L, Coy CS, Callejas-Neto F, Fagundes JJ, Góes JR: [Gastroduodenal polyposis in patients with familiar adenomatous polyposis after rectocolectomy]. Arq Gastroenterol; 2007 Apr-Jun;44(2):133-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gastroduodenal polyposis in patients with familiar adenomatous polyposis after rectocolectomy].
  • BACKGROUND: The extra colonic manifestations, like upper gastrointestinal tract polyps and duodenal cancer are disorders that affect long-term morbidity and mortality of patients with familial adenomatous polyposis, after rectocolectomy.
  • AIM: To describe the frequency of those disorders in patients with familial adenomatous polyposis and to review efficacy of upper gastrointestinal endoscopic surveillance.
  • METHODS: Between 1984 and 2005, 62 patients with familial adenomatous polyposis after rectocolectomy, were studied retrospectively, by Coloproctology Group, Medical Sciences Faculty, State University of Campinas, SP, Brazil.
  • RESULTS: Twenty seven (50,9%) of 53 patients in follow-up had upper gastrointestinal polyps.
  • Eight (15,4%) had gastric adenomatous polyps, 14 (27%), duodenal polyps and 5 (9,6%) duodenal and gastric polyps.
  • Two patients (3,8%) had adenomatous duodenal polyps with severe dysplasia, and one (1,9%) had adenocarcinoma of the duodenal papilla.
  • CONCLUSION: The upper gastrointestinal endoscopic surveillance has importance and the aim is to detect as early as possible the occurrence of duodenal adenocarcinoma and upper gastrointestinal polyps with severe dysplasia.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Duodenal Neoplasms / diagnosis. Endoscopy, Digestive System. Polyps / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 17962858.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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51. Alkhouri N, Franciosi JP, Mamula P: Familial adenomatous polyposis in children and adolescents. J Pediatr Gastroenterol Nutr; 2010 Dec;51(6):727-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Familial adenomatous polyposis in children and adolescents.
  • BACKGROUND: Familial adenomatous polyposis (FAP) is the most common inherited polyposis syndrome characterized by the development of hundreds of colorectal adenomatous polyps.
  • The aim of this study was to review cases of FAP diagnosed at The Children's Hospital of Philadelphia in a 16-year period.
  • The collected data included disease presentation, genetic profile, extraintestinal manifestations, surveillance, and treatment.
  • The youngest age at which polyps were detected was 7 years.
  • Four patients had adenomatous polyposis coli gene mutation identified.
  • One patient was diagnosed as having rectal carcinoma in situ.
  • Six patients (50%) had gastric fundic gland polyposis and 6 had duodenal adenomatous changes.
  • Capsule endoscopy was performed in 3 patients; 1 had multiple polyps in the duodenum and the jejunum.
  • CONCLUSIONS: FAP is a rare condition but with significant risk of cancer and comorbidity.
  • The youngest patient with polyps detected was 7 years old.
  • We identified 1 patient with rectal cancer in situ and high proportion of patients with duodenal adenomatous lesions.
  • [MeSH-major] Adenomatous Polyposis Coli
  • [MeSH-minor] Adolescent. Age of Onset. Child. Female. Hemorrhage / genetics. Hemorrhage / surgery. Humans. Intestinal Neoplasms / etiology. Male. Retrospective Studies

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  • (PMID = 20808249.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Teichmann J, Weickert U, Riemann JF: Gastric fundic gland polyps and colonic polyps - is there a link, really? Eur J Med Res; 2008 May 26;13(5):192-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric fundic gland polyps and colonic polyps - is there a link, really?
  • Gastric fundic gland polyps occur in patients with familial adenomatous polyposis.
  • The aim of our study was to investigate if colonic polyps is present and related to gastric fundic gland polyps.
  • At baseline upper gastrointestinal endoscopy, gastric fundic gland polyps were diagnosed in patients suffered from intestinal bleeding.
  • A total of 500 patients were enrolled into study: 250 fulfilled the diagnostic criteria for gastric fundic gland polyps and 250 age and sex matched served as controls.
  • RESULTS: Colonic cancer was more frequently observed in 39 (15.5%) patients who met the criteria of gastric fundic gland polyps as compared to 23 (9.2 %) patients of the controls (p <0.05).
  • Patients with gastric fundic gland polyps tended to have more often colonic polyps 122 vs. 111, but these differences were not statistically significant.
  • CONCLUSION: The prevalence of colonic cancer was elevated in patients with gastric fundic gland polyp.
  • Furthermore, this relationship did not differ significantly according to occurrence of colonic polyps.
  • Even tough colonoscopy is prophylactic in preventing colonic cancer; the use of colonoscopy should be encouraged in patients with gastric fundic gland polyps.
  • [MeSH-major] Colonic Polyps / epidemiology. Gastric Fundus / pathology. Polyps / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonoscopy. Colorectal Neoplasms / epidemiology. Humans. Incidence. Middle Aged. Retrospective Studies

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  • (PMID = 18559299.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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