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Items 1 to 52 of about 52
1. Byun TJ, Han DS, Ahn SB, Cho HS, Eun CS, Jeon YC, Sohn JH, Oh YH: Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer. Gut Liver; 2009 Jun;3(2):130-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer.
  • Pseudoinvasion or pseudocarcinomatous invasion in an adenomatous polyp of the colon can be unfamiliar to an endoscopist.
  • Pseudoinvasion in an adenomatous polyp represents prolapse of the adenomatous epithelium into its stalk.
  • In most cases its morphology does not differ from of general adenomatous polyps, but in some cases it can morphologically mimic a malignant polyp with submucosal invasion due to mass-like lesioning of its stalk.
  • We report on an 82-year-old man who presented with a large pedunculated polyp with a thick stalk in the sigmoid colon, which mimicked a submucosal invasive carcinoma.
  • The patient was diagnosed with pseudoinvasion in an adenomatous polyp after segmental resection of the sigmoid colon.

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  • (PMID = 20431736.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852693
  • [Keywords] NOTNLM ; Adenomatous polyps / EUS / Malignant polyp / Pseudoinvasion
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2. Ramirez M, Schierling S, Papaconstantinou HT, Thomas JS: Management of the malignant polyp. Clin Colon Rectal Surg; 2008 Nov;21(4):286-90

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  • [Title] Management of the malignant polyp.
  • In the United States, the prevalence of adenomatous polyps found during colonoscopic evaluation ranges from 25 to 41%, and of these, 2 to 5% contain invasive malignancy.
  • The management of the malignant polyp continues to be challenging.

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  • (PMID = 20011440.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780260
  • [Keywords] NOTNLM ; Haggitt level / Malignant polyp / adenocarcinoma / adenomatous polyp / endoscopic polypectomy / segmental colectomy
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3. Erdem L, Akbayir N, Yildirim S, Köksal HM, Yenice N, Gültekin OS, Sakiz D, Peker O: Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon. Turk J Gastroenterol; 2005 Dec;16(4):207-11
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • [Title] Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon.
  • METHODS: Patients found to have rectosigmoid adenomatous polyps on colonoscopy were included in the study.
  • Polyps found in the rectum and sigmoid colon were considered as distal polyps and polyps other than these were considered as proximal polyps.
  • RESULTS: In this study, of 1124 consecutive patients who underwent colonoscopy between April 1997 and January 2002, 184 (16%) had 258 adenomatous polyps in the rectosigmoid area.
  • In 104 patients (57%) with polyp(s) in rectum and sigmoid colon, no associated polyp or cancer was encountered in the proximal colon.
  • CONCLUSION: Colonoscopy is indicated when adenomatous polyp, regardless of size, is found on rectosigmoidoscopy performed because of symptoms.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neoplasms, Multiple Primary. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 16547849.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Turkey
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4. Zhou PH, Yao LQ, Chen WF: [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum]. Zhonghua Wai Ke Za Zhi; 2008 Sep 15;46(18):1386-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum].
  • OBJECTIVE: To assess the clinical efficacy of endoscopic treatment for colorectal adenomatous polyps and early-stage carcinomas.
  • METHODS: Between January 2006 and October 2007, 245 patients with colorectal adenomatous polyps and early-stage carcinomas with lifting sign(+) were treated by such endoscopic techniques as polypectomy, endoscopic mucosal resection (EMR), endoscopic piecemeal mucosal resection (EPMR) and endoscopic submucosal dissection (ESD).
  • CONCLUSIONS: Endoscopic resection appears to be an efficacious procedure to treat adenomatous polyp and early-stage carcinoma and provide pathological information about the whole lesion.
  • [MeSH-major] Adenomatous Polyps / surgery. Colorectal Neoplasms / surgery. Endoscopes, Gastrointestinal

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  • (PMID = 19094508.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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5. Ukarapol N, Singhavejakul J, Lertprasertsuk N, Wongsawasdi L: Juvenile polyp in Thai children--clinical and colonoscopic presentation. World J Surg; 2007 Feb;31(2):395-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juvenile polyp in Thai children--clinical and colonoscopic presentation.
  • BACKGROUND: The aim of this prospective study was to describe the clinical characteristics of colorectal polyp in Thai children.
  • METHODS: From December 2002 to February 2005, children under 15 years of age presenting with rectal bleeding were prospectively enrolled.
  • The most common presenting symptom was hematochezia, followed by prolapsing rectal mass and diarrhea.
  • In 20 patients there was a single polyp, 6 had 2-4 polyps, and 6 were diagnosed with polyposis coli.
  • Most of the polyps were located exclusively at the rectum and sigmoid colon.
  • All were juvenile polyps without evidence of adenomatous changes.
  • Compared to those with isolated polyps, the patients with polyposis coli had a statistically significant incidence of right-sided polyps (P <0.001) and a history of prolapse of the rectal mass (P = 0.006).
  • CONCLUSIONS: Because of the high prevalence of right-sided polyps and the concern about malignant transformation, colonoscopy should be considered as the initial evaluation in children with rectal bleeding.
  • [MeSH-major] Asian Continental Ancestry Group. Colonic Polyps / ethnology. Colonic Polyps / pathology. Colonoscopy. Rectal Diseases / ethnology. Rectal Diseases / pathology
  • [MeSH-minor] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / ethnology. Adenomatous Polyposis Coli / pathology. Adolescent. Child. Child, Preschool. Female. Humans. Infant. Male. Prospective Studies. Thailand

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  • (PMID = 17235457.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
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6. West NJ, Clark SK, Phillips RK, Hutchinson JM, Leicester RJ, Belluzzi A, Hull MA: Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. Gut; 2010 Jul;59(7):918-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis.
  • The present study tested whether a novel, enteric-coated formulation of EPA, as the free fatty acid (EPA-FFA), has chemopreventative efficacy in patients with familial adenomatous polyposis (FAP), in a randomised, double-blind, placebo-controlled trial.
  • METHODS: Patients undergoing endoscopic surveillance of their retained rectum postcolectomy were randomised to EPA-FFA (SLA Pharma) 2 g daily or placebo for 6 months.
  • Global rectal polyp burden was scored (-1, 0, +1) by examination of video endoscopy records.
  • Treatment with EPA-FFA for 6 months was associated with a mean 22.4% (95% CI 5.1% to 39.6%) reduction in polyp number (p=0.012) and a 29.8% (3.6% to 56.1%) decrease in the sum of polyp diameters (p=0.027).
  • Global polyp burden worsened over 6 months in the placebo group (-0.34) unlike the EPA-FFA group (+0.09, difference 0.42 (0.10-0.75), p=0.011).
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Anticarcinogenic Agents / therapeutic use. Eicosapentaenoic Acid / therapeutic use. Intestinal Polyps / prevention & control. Rectal Neoplasms / prevention & control

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  • [CommentIn] Gut. 2010 Jul;59(7):871-3 [20581233.001]
  • (PMID = 20348368.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00510692
  • [Grant] United Kingdom / Medical Research Council / / G116/146
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Fatty Acids; AAN7QOV9EA / Eicosapentaenoic Acid
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7. Sieber OM, Segditsas S, Knudsen AL, Zhang J, Luz J, Rowan AJ, Spain SL, Thirlwell C, Howarth KM, Jaeger EE, Robinson J, Volikos E, Silver A, Kelly G, Aretz S, Frayling I, Hutter P, Dunlop M, Guenther T, Neale K, Phillips R, Heinimann K, Tomlinson IP: Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. Gut; 2006 Oct;55(10):1440-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
  • BACKGROUND: Attenuated familial adenomatous polyposis (AFAP) is associated with germline mutations in the 5', 3', and exon 9 of the adenomatous polyposis coli (APC) gene.
  • METHODS AND RESULTS: We found that colonic polyp number varied greatly among AFAP patients but members of the same family tended to have more similar disease severity.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Germ-Line Mutation / genetics
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / genetics. Adult. Aged. DNA Mutational Analysis. Exons. Female. Humans. Loss of Heterozygosity. Male. Middle Aged. Phenotype. Polymorphism, Single Nucleotide

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  • (PMID = 16461775.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U127527198
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
  • [Other-IDs] NLM/ PMC1856441
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8. Cleary SP, Kim H, Croitoru ME, Redston M, Knight JA, Gallinger S, Gryfe R: Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. Dis Colon Rectum; 2008 Oct;51(10):1467-73; discussion 1473-4
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  • [Title] Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk.
  • PURPOSE: Whereas truncating germline mutations of the adenomatous polyposis coli (APC) gene give rise to familial adenomatous polyposis, missense polymorphisms of APC may confer a weaker risk for colorectal cancer.
  • Missense adenomatous polyposis coli alterations identified in this colorectal cancer multiple-polyp population were analyzed in a population-based series of patients with colorectal cancer and healthy control subjects.
  • RESULTS: Germline APC or mutY human homologue (MYH) alterations were identified in 16 of 39 colorectal cancer-multiple polyp patients.

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  • (PMID = 18612690.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA074783-06; United States / NCI NIH HHS / CA / CA074783-06; United States / NCI NIH HHS / CA / CA074783-07; United States / NCI NIH HHS / CA / U01 CA074783; United States / NCI NIH HHS / CA / U01 CA074783-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS139709; NLM/ PMC2768068
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9. Voloyiannis T, Snyder MJ, Bailey RR, Pidala M: Management of the difficult colon polyp referred for resection: resect or rescope? Dis Colon Rectum; 2008 Mar;51(3):292-5
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  • [Title] Management of the difficult colon polyp referred for resection: resect or rescope?
  • Before colectomy the experienced surgeon has the option of repeating the colonoscopy to assess the polyp, tattoo the site, and potentially remove the polyp.
  • METHODS: All new patients referred during a five-year period to an 11-physician colon and rectal surgical group with the diagnosis of colon polyp (CPT 211.3) that was not previously removed were retrospectively reviewed.
  • Patients with rectal polyps, inflammatory bowel disease, previous cancer, or familial adenomatous polyposis were excluded.
  • In 26 cases the polyp site was tattooed for later localization.

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  • [ErratumIn] Dis Colon Rectum. 2008 Aug;51(8):1300
  • (PMID = 18202891.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Sinha A, Tekkis PP, Rashid S, Phillips RK, Clark SK: Risk factors for secondary proctectomy in patients with familial adenomatous polyposis. Br J Surg; 2010 Nov;97(11):1710-5
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  • [Title] Risk factors for secondary proctectomy in patients with familial adenomatous polyposis.
  • BACKGROUND: Colectomy and ileorectal anastomosis (IRA) or restorative proctocolectomy are performed for prophylaxis in familial adenomatous polyposis (FAP).
  • After IRA patients may require secondary proctectomy for worsening polyposis or rectal cancer.
  • Outcomes after IRA were evaluated and risk factors predictive of progressive rectal disease identified.
  • METHODS: Parametric survival analysis was used to identify predictors of progressive rectal disease in all patients undergoing an IRA for FAP at a single centre.
  • RESULTS: Of 427 patients who underwent IRA, 48 (11.2 per cent) developed rectal cancer and 77 (18.0 per cent) required proctectomy for worsening polyposis over a median follow-up of 15 (range 7-25) years.
  • By the age of 60 years half of the patients retained their rectum.
  • Rectal polyp count exceeding 20 (HR 30.99, 95 per cent confidence interval 9.57 to 100.32; P < 0.001), APC mutation codon 1250-1450 (HR 3.91, 1.45 to 10.51; P = 0.007), colonic polyp count 500 or more (HR 2.18, 1.24 to 3.82; P = 0.006) and age less than 25 years at the time of surgery (HR 1.99, 1.17 to 3.37; P = 0.011) were independent predictors of progressive rectal disease.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Neoplasm Recurrence, Local / surgery. Proctocolectomy, Restorative. Rectal Neoplasms / surgery

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  • [Copyright] Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 20665483.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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11. Neneman B, Gasiorowska A, Małecka-Panas E: The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon. Adv Med Sci; 2006;51:88-93
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  • [Title] The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon.
  • The aim of the study was to assess the outcome and safety of argon plasma coagulation (APC) in the management of gastric and colorectal polyp remnants after polypectomy, and to search for clinical parameters useful in predicting the efficacy of this technique.
  • All those polyps were removed at colonoscopy with the diathermic snare and the polyp remnants were destroyed with APC using Argon Beamer source (Erbe, Germany).
  • Effective destruction of polyp remnants was achieved in 20 (90.9%) gastric polyps in 16 (88.9%) patients.
  • Significant positive correlation was demonstrated between the power output, APC sessions number and polyp location in the prepyloric part, its size and adenomatous content.
  • Effective destruction of remnant polyp tissue was obtained in 56 (96.4%) polyps in 27 (93.1%) patients.
  • A significant positive correlation between the power output and the size, distal location and villous texture of the polyp has been demonstrated.
  • CONCLUSIONS: APC is an effective and safe method in the management of polyp remnants in the stomach and colon.
  • The application of higher electric power and numerous APC sessions are necessary to remove residues of large gastric polyps located in the prepyloric part and of with adenomatous content.
  • In the case of colonic polyps the application of higher electric power should be recommended in case of large-sized lesions, located in rectum and of villous texture.

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  • (PMID = 17357283.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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12. Valanzano R, Ficari F, Curia MC, Aceto G, Veschi S, Cama A, Battista P, Tonelli F: Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis. J Surg Oncol; 2007 Jan 1;95(1):28-33
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  • [Title] Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis.
  • BACKGROUND AND OBJECTIVES: The number of rectal polyps and the site of mutations in the APC (Adenomatous polyposis coli) gene have been used to guide the surgical management in patients with familial adenomatous polyposis (FAP).
  • The aim of this study is to assess the utility of the APC mutation screening compared to the degree of the rectal polyposis in surgical decision making.
  • Preservation of the rectum was prospectively decided on the basis of well-defined endoscopic criteria.
  • The number of rectal polyps was assessed preoperatively and every 6-12 months.
  • RESULTS: On the basis of preoperative polyp rectal count we categorized patients as follows: Group I, 5 or fewer adenomas; Group II, 6-9 adenomas; Group III, 10 or more adenomas.
  • After a follow-up ranging from 12 to 225 months we have observed a significant difference of recurrent rectal adenomas between Groups I-II versus III.
  • Carpeting polyposis of the rectal stump developed in three patients with APC mutation at codon 1309 and two of them needed later proctectomy.
  • Diffuse rectal polyposis was observed in one patient with mutation at exon 9 who had 10 small polyps at time of surgery.
  • No IRA patients developed rectal cancer.
  • CONCLUSIONS: In our experience fewer than 10 rectal polyps at presentation can predict a favorable outcome after IRA.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / surgery. Genes, APC. Germ-Line Mutation. Proctoscopy
  • [MeSH-minor] Adult. Anastomosis, Surgical. Colectomy. Female. Humans. Ileum / surgery. Male. Middle Aged. Patient Selection. Polymorphism, Single-Stranded Conformational. Rectum / surgery. Treatment Outcome

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  • (PMID = 17192888.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Parfitt JR, Shepherd NA: Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp! Histopathology; 2008 Jul;53(1):91-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp!
  • METHODS AND RESULTS: Four cases of low rectal adenoma with polypoid mucosal prolapse were assessed histopathologically, as well as with p53 and Ki67 antibodies.
  • CONCLUSIONS: Histopathologists must recognize the potential for adenomatous/dysplastic foci in anorectal lesions to superficially resemble inflammatory cloacogenic polyps.
  • [MeSH-major] Adenoma / pathology. Intestinal Mucosa / pathology. Intestinal Polyps / diagnosis. Rectal Neoplasms / pathology. Rectal Prolapse / pathology. Rectum / pathology

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  • (PMID = 18484980.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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14. Gonzalez AB, Stafford I, Mancuso P, Carney S: Delivery of a polyp. Obstet Gynecol; 2008 Aug;112(2 Pt 2):488-90
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  • [Title] Delivery of a polyp.
  • CASES: Three women in their 30s passed or prolapsed adenomatous tissue per rectum during the second stage of labor.

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  • (PMID = 18669775.001).
  • [ISSN] 0029-7844
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM: Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2006 Aug;4(8):1035-8
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  • [Title] Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis.
  • METHODS: Five FAP patients with prior colectomy (4 with retained rectum and 1 with an ileal anal pouch) received curcumin 480 mg and quercetin 20 mg orally 3 times a day.
  • RESULTS: All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin.
  • CONCLUSIONS: The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with FAP without appreciable toxicity.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Antineoplastic Agents / therapeutic use. Antioxidants / therapeutic use. Curcumin / therapeutic use. Quercetin / therapeutic use

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  • (PMID = 16757216.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / K07 CA092445; United States / NCI NIH HHS / CA / P50 CA 62924-10
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antioxidants; 9IKM0I5T1E / Quercetin; IT942ZTH98 / Curcumin
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16. Beaton MD, Taylor B, Driman D, Ainsworth P, Adams PC: Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation? Can J Gastroenterol; 2008 Jul;22(7):634-6
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  • [Title] Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation?
  • Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps.
  • While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colonic Polyps / pathology

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17. Suraweera N, Latchford A, McCart A, Rogers P, Spain S, Sieber O, Phillips R, Tomlinson I, Silver A: Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. J Med Genet; 2007 Aug;44(8):541-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.
  • Familial adenomatous polyposis (FAP) patients carry a germline adenomatous polyposis coli (APC) mutation predisposing to multiple adenoma formation in the intestine.
  • [MeSH-minor] Adenomatous Polyposis Coli. Colectomy. Female. Germ-Line Mutation. Humans. Mutation. Pregnancy. Regression Analysis. Siblings

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  • (PMID = 17496195.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
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18. Aust DE, Baretton GB, Members of the Working Group GI-Pathology of the German Society of Pathology: Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria. Virchows Arch; 2010 Sep;457(3):291-7
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  • [Title] Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria.
  • Until recently, two major types of colorectal epithelial polyps were distinguished: the adenoma and the hyperplastic polyp.
  • This group of polyps is comprised not only of hyperplastic polyps, but also of sessile serrated adenomas, traditional serrated adenomas and mixed polyps, showing serrated and "classical" adenomatous features.
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Humans. Rectum / pathology

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  • (PMID = 20617338.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 36
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19. Saad A, Rex DK: Routine rectal retroflexion during colonoscopy has a low yield for neoplasia. World J Gastroenterol; 2008 Nov 14;14(42):6503-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Routine rectal retroflexion during colonoscopy has a low yield for neoplasia.
  • AIM: To investigate the value of retroflexion in detecting neoplasia in the distal rectum.
  • Consecutive patients undergoing colonoscopy had careful forward viewing of the distal rectum by retroflexion.
  • The outcome measurement was the yield of neoplasia in the distal rectum detected by forward viewing vs retroflexion.
  • Retroflexion was successful in 1411 (93.9%) patients, unsuccessful or not performed because the rectum appeared narrow in 91 (6.1%).
  • Forty patients had a polyp detected in the distal rectal mucosa.
  • Thirty-three were visible in both the forward and retroflexed view (25 hyperplastic, 8 adenomatous).
  • CONCLUSION: To our knowledge, this is the largest reported evaluation of retroflexion in the rectum.
  • Routine rectal retroflexion did not detect clinically important neoplasia after a careful forward examination of the rectum to the dentate line.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Colonoscopy / methods. Intestinal Polyps / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Digital Rectal Examination. Female. Humans. Male. Middle Aged. Patient Selection. Predictive Value of Tests. Prospective Studies. Young Adult

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  • (PMID = 19030202.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2773336
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20. Rocha Ramírez JL, Villanueva Sáenz E, Hernández-Magro PM, Sierra Montenegro E, Soto Quirino R, Pérez Aguirre J, Blanco Lemus E: [Hereditary mixed polyposis syndrome. First report in Mexico]. Rev Gastroenterol Mex; 2005 Oct-Dec;70(4):430-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At blood test with hemoglobin of 9.7 g/dL, and colonoscopy with multiple polyps within colon and rectum, upper endoscopy with a big esophageal polyp and multiple polyps in gastric and duodenal lining smaller than 1 cm.
  • Histopathologic study of the polyps report mixed pattern of polyps: (hyperplasic-adenomatous, juvenile-adenomatous, adenoma-inflammatory-hyperplasic, hyperplasic-adenomatous with a high degree dysplasia); juvenile in esophagus, and hyperplasic in stomach and duodenum.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis

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  • (PMID = 17058983.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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21. Nikpour S, Ali Asgari A: Colonoscopic evaluation of minimal rectal bleeding in average-risk patients for colorectal cancer. World J Gastroenterol; 2008 Nov 14;14(42):6536-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonoscopic evaluation of minimal rectal bleeding in average-risk patients for colorectal cancer.
  • AIM: To assess the prevalence of clinically significant lesions in patients with minimal bright red bleeding per rectum (BRBPR).
  • Significant lesions were found in 121 (30.1%) patients, including 26 patients (6.5%) with adenocarcinoma and 30 (7.5%) with adenomatous polyps.
  • Almost all patients with significant lesions had at least one lesion in the distal colon; an adenocarcinoma and an adenomatous polyp in the proximal colon were found in 2 patients with hemorrhoids.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Hemorrhage / etiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Colitis, Ulcerative / complications. Colitis, Ulcerative / diagnosis. Female. Fissure in Ano / complications. Fissure in Ano / diagnosis. Hemorrhoids / complications. Hemorrhoids / diagnosis. Humans. Male. Middle Aged. Patient Selection. Predictive Value of Tests. Prevalence. Prospective Studies. Rectum. Risk Assessment. Sigmoidoscopy. Young Adult


22. Avanesian AA, Shcherbakov AM: [An experience with clinical endoscopy and argon-plasma coagulation for removal of large bowel polyps]. Vopr Onkol; 2005;51(5):592-4
Hazardous Substances Data Bank. Argon, Elemental .

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  • Polyps presented as sitting on a wide pedicle (25), sprawling (19) or spreading flat (7) in rectum (24), sigmoid (18) or colon (9).
  • Polyp diameter ranged 1.0-1.9 cm (12 adenomas), 2-2.9 (18) or 3-5 cm (21).
  • Coagulation was carried out immediately after partial removal of polyp with the aid of diathermic loop.
  • [MeSH-major] Colon / surgery. Colonoscopy / methods. Electrocoagulation. Rectum / surgery
  • [MeSH-minor] Adenomatous Polyposis Coli / surgery. Adult. Aged. Aged, 80 and over. Argon / therapeutic use. Female. Follow-Up Studies. Humans. Male. Middle Aged. Plasma. Retrospective Studies. Treatment Outcome

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  • (PMID = 16756019.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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23. Holt PR, Bresalier RS, Ma CK, Liu KF, Lipkin M, Byrd JC, Yang K: Calcium plus vitamin D alters preneoplastic features of colorectal adenomas and rectal mucosa. Cancer; 2006 Jan 15;106(2):287-96
Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .

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  • [Title] Calcium plus vitamin D alters preneoplastic features of colorectal adenomas and rectal mucosa.
  • METHODS: In the current study, adenomatous polyps were transected, approximately 50% were removed for histologic examination, and the remnants tattooed before the administration of either calcium carbonate (1500 mg 3 times daily) plus vitamin D(3) 400 IU or a placebo for 6 months.
  • At study end, polyp remnants were resected completely and were used for histologic examination.
  • Immunohistochemical staining was performed in both flat mucosa and in polyp tissue.
  • Vitamin D receptor staining increased slightly and significantly in flat rectal tissue in the treatment group.
  • CONCLUSIONS: The administration of a calcium plus vitamin D chemopreventive regimen resulted in several changes in adenomatous tissue that may have contributed to reduced polyp formation.
  • [MeSH-major] Adenoma / drug therapy. Adenomatous Polyps / drug therapy. Calcium / administration & dosage. Colorectal Neoplasms / prevention & control. Precancerous Conditions / drug therapy. Vitamin D / administration & dosage
  • [MeSH-minor] Apoptosis. Biomarkers, Tumor / analysis. Cell Proliferation. Female. Humans. Intestinal Mucosa / drug effects. Intestinal Mucosa / pathology. Male. Middle Aged. Rectum / pathology

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  • (PMID = 16353199.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01CN25439-1; United States / NCI NIH HHS / CA / R01CA69480
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 1406-16-2 / Vitamin D; SY7Q814VUP / Calcium
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24. Fenoglio L, Castagna E, Comino A, Luchino C, Senore C, Migliore E, Capucci F, Panzone S, Silvestri A, Ghezzo L, Ferrigno D: A shift from distal to proximal neoplasia in the colon: a decade of polyps and CRC in Italy. BMC Gastroenterol; 2010;10:139

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  • This study aims to evaluate the distribution of CRC and adenomatous polyps (ADP) to establish the presence of proximalization and to assess the potential predictors.
  • The main predictor of proximal advanced neoplasia was the number of polyps detected per exam (> 1 polyp versus 1 polyp: considering all ADP: OR 2.16; 95% CI: 1.59-2.93; considering advanced ADP OR 1.63; 95% CI: 1.08-2.46).
  • [MeSH-major] Adenomatous Polyps / pathology. Colon / pathology. Colonic Neoplasms / pathology

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  • (PMID = 21108823.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3001711
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25. Will OC, Leedham SJ, Elia G, Phillips RK, Clark SK, Tomlinson IP: Location in the large bowel influences the APC mutations observed in FAP adenomas. Fam Cancer; 2010 Sep;9(3):389-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In both sporadic colorectal cancer and Familial Adenomatous Polyposis (FAP), polyp density and cancer susceptibility vary markedly by colonic site.
  • In polyps from patients with a 1309 mutation, the frequency of LOH showed a gradient from rectum (highest) to caecum/ascending colon (lowest), but this was not present in patients with proximal germline APC mutations.
  • Beta-catenin and caspase-3 expression showed no significant variation by colonic region, but Ki-67 expression decreased from ascending colon to rectum in tumours and normal tissue.
  • The higher frequency of LOH in rectal polyps from patients with codon 1309 mutations may help to explain their increased polyp burden at this site compared with patients who have other germline APC mutations.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Genes, APC. Intestine, Large / pathology

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  • (PMID = 20229069.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / beta Catenin; EC 3.4.22.- / Caspase 3
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26. Wolf LA, Terry PD, Potter JD, Bostick RM: Do factors related to endogenous and exogenous estrogens modify the relationship between obesity and risk of colorectal adenomas in women? Cancer Epidemiol Biomarkers Prev; 2007 Apr;16(4):676-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cases (n = 219) were women of ages 30 to 74 years with colonoscopy proven, incident, sporadic, pathology-confirmed, adenomatous polyps of the colon and rectum.
  • Two control groups were recruited: colonoscopy-confirmed polyp-free women (n = 438) and age- and zip code frequency-matched women randomly selected from the community (n = 247).
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colorectal Neoplasms / epidemiology. Estrogens / pharmacology. Estrogens / physiology. Obesity

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  • (PMID = 17416757.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens
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27. Barreda Costa C, Vila Gutierrez S, Salazar Cabrera F, Barriga Calle E, Velarde Criado H, Barriga Briceño J: [Advanced adenoma in 3700 colonoscopies]. Rev Gastroenterol Peru; 2010 Apr-Jun;30(2):113-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Each polyp was studied separately and its histological findings recorded.
  • 997 (27%) had adenomatous polyps and 495 (13.4%) non adenomatous polyps.
  • Adenomatous polyps were found throughout the colon, with a predominance of hyperplasic polyps in the rectum.
  • 78% of the adenomatous polyps and 84% of the advanced adenomas were found in patients older than 50 years old.
  • In this group of patients, significant risk factors were: prior history of adenomas or colorectal cancer (46/203 vs. 63/495; p<0.01), and multiple adenomatous polyps found during colonoscopy (67/203 vs. 121/794; p<0.01).
  • CONCLUSIONS: Adenomatous polyps were the most frequently found polyps in our study; approximately 20% were advanced lesions, especially in patients older than 50 years old.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Colonoscopy / statistics & numerical data. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / epidemiology. Adenomatous Polyps / pathology. Adult. Age Factors. Aged. Aged, 80 and over. Early Diagnosis. Humans. Hyperplasia. Middle Aged. Motivation. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / pathology. Organ Specificity. Peru / epidemiology. Prospective Studies. Young Adult

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  • (PMID = 20644602.001).
  • [ISSN] 1609-722X
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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28. Yantiss RK, Oh KY, Chen YT, Redston M, Odze RD: Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases. Am J Surg Pathol; 2007 Aug;31(8):1238-45
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  • In this study, we describe a previously uncharacterized type of adenomatous polyp of the colorectum that shows prominent, thin, elongated projections of neoplastic epithelium with a serrated contour, which we have termed "filiform serrated adenoma" (SA).
  • All 18 filiform SAs were located in the left colon, including 15 (83%) that occurred in the rectum, compared with 43% of the control group (P=0.03).
  • Four (22%) filiform SAs also contained nonserrated adenomatous elements with a villous (3 cases) or tubular (1 case) growth pattern.
  • Four cases showed silent p53 mutations upon direct sequencing and 4 revealed loss of heterozygosity at the loci evaluated, including 1 at D5S346 [adenomatous polyposis coli (APC) gene], 1 at D17S250 (p53 gene), and 2 at MYCL (chromosome 1p34).
  • We conclude that filiform SA potentially represents an unusual variant of SA with a predilection for the left colon, particularly the rectum.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17667549.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Genetic Markers; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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29. Baxter N, Rabeneck L: New findings about the risks and limitations of colonoscopy used in the early detection of colorectal cancer. Healthc Q; 2009;12(2):24-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colonoscopy is widely used to detect both colorectal cancer and adenomatous polyps, which may become malignant if left alone.
  • During a complete colonoscopy, a physician - usually a gastroenterologist or general surgeon - inserts a long, flexible tube called a colonoscope through the patient's rectum and along the length of the large bowel.
  • If such a polyp or lesion is detected, it can often be removed during the colonoscopy so that no additional procedures or surgery are needed.

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  • (PMID = 19369808.001).
  • [ISSN] 1710-2774
  • [Journal-full-title] Healthcare quarterly (Toronto, Ont.)
  • [ISO-abbreviation] Healthc Q
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
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30. Khodadoostan M, Fatemi R, Maserat E, Hooshang A, Alizade M, Molaie M, Mashaiekhy R, Moaddab Y, Poor SY, Hashemy A, Zali MR: Clinical and pathological characteristics of colorectal polyps in Iranian population. East Afr J Public Health; 2010 Jun;7(2):157-9
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  • 3.12 percent of polyps were located in the rectum, 19.6 percent in sigmoid, 24.4 percent in descending colon, 13.9 percent in transverse colon, 29.6 percent were in cecum and ascending colon.
  • Of them 354 were advance polyp (> 1 cm, villous type, high grade dysplasia).
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Colon / pathology. Colonoscopy. Cross-Sectional Studies. Female. Humans. Iran. Male. Middle Aged. Rectum / pathology. Sex Distribution

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  • (PMID = 21413595.001).
  • [ISSN] 0856-8960
  • [Journal-full-title] East African journal of public health
  • [ISO-abbreviation] East Afr J Public Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Tanzania
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31. Tytherleigh MG, Warren BF, Mortensen NJ: Management of early rectal cancer. Br J Surg; 2008 Apr;95(4):409-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of early rectal cancer.
  • BACKGROUND: Early rectal cancer (ERC) is adenocarcinoma that has invaded into, but not extended beyond, the submucosa of the rectum (that is a T1 tumour).
  • RESULTS AND CONCLUSION: ERC presents as a focus of malignancy within an adenoma, as a polyp, or as a small ulcerating adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenomatous Polyps / surgery. Chemotherapy, Adjuvant. Follow-Up Studies. Humans. Lymphatic Metastasis. Microsurgery / methods. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging / methods. Preoperative Care / methods. Prognosis. Radiotherapy, Adjuvant. Risk Factors

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  • [Copyright] 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • [CommentIn] Br J Surg. 2008 Sep;95(9):1189-90; author reply 1190 [18690612.001]
  • (PMID = 18314929.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 124
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32. Beggs AD, Hodgson SV: The genomics of colorectal cancer: state of the art. Curr Genomics; 2008 Mar;9(1):1-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
  • Initial studies of the genetics of inherited colorectal cancer susceptibility concentrated on the inherited colorectal cancer syndromes, such as Familial Adenomatous Polyposis (FAP) and Lynch Syndrome (also known as HNPCC).
  • Recent research has concentrated on the pathways by which colorectal adenomatous polyps not due to one of these known inherited susceptibilities undergo malignant transformation, and determination of the types of polyps most likely to do so.

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  • (PMID = 19424478.001).
  • [ISSN] 1389-2029
  • [Journal-full-title] Current genomics
  • [ISO-abbreviation] Curr. Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2674304
  • [Keywords] NOTNLM ; Colorectal / cancer / epigenomics. / genomics
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33. Clements D, Tawfiq S, Harries B, Sheridan W: Application of the BSG guidelines to a colonoscopy waiting list. Colorectal Dis; 2009 Jun;11(5):513-5
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The reasons for removal from the list were as follows: Thirty-nine patients were older than the upper age limit, 23 had had clear colonoscopies after adenomatous polyp follow up, four were listed for diverticular disease follow up, four for metaplastic polyps, one for constipation and one for per rectum (PR) bleed follow up.

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  • (PMID = 18637926.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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34. Romano G, Cocchiara G, Maniaci S, Buscemi G, Calderone F, Gioè FP, Romano M: [The role of colonoscopy in patient follow-up after surgery for colorectal cancer. A retrospective study and review of the literature]. G Chir; 2007 Oct;28(10):399-402
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To improve survival rate after colon or rectum resection for cancer patients should be strictly followed up in order to identify possible local disease relapse or metachronous neoplasia.
  • In addition, in 11 cases, there were 3 right colon adenomatous polyps, 2 transverse colon polyps (one villous and the other tubular), 5 descending colon polyps (three tubular and two villous) and 1 tubulo-villous polyp of the rectum.

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  • (PMID = 17915057.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 55
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35. Durno CA: Colonic polyps in children and adolescents. Can J Gastroenterol; 2007 Apr;21(4):233-9
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • Colonic polyps most commonly present with rectal bleeding in children.
  • The isolated juvenile polyp is the most frequent kind of polyp identified in children.
  • 'Juvenile' refers to the histological type of polyp and not the age of onset of the polyp.
  • Attenuated familial adenamatous polyposis (AFAP) can occur either by a mutation at the extreme ends of the adenomatous polyposis coli gene or by biallelic mutations in the mutY homologue (MYH) gene.
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Adolescent. Child. DNA Glycosylases / genetics. Genes, APC. Genetic Counseling. Genetic Predisposition to Disease. Genetic Testing. Humans. Mutation

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  • (PMID = 17431512.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Number-of-references] 47
  • [Other-IDs] NLM/ PMC2657698
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36. Li FE, Ye HJ, Li J, Wang JP, Liu YG, Yu GY, Yin WH: [Clinical, enteroscopic, and pathological characteristics of 796 cases of colorectal polyps]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2005 Aug;30(4):463-6
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • OBJECTIVE: To study the age, clinical, enteroscopic and pathological characteristics of colorectal polyps and factors affected polyp-carcinoma.
  • The rate of colorectal polyp was 82.29% in 30-69 year olds.
  • The adenomatous, inflammatory, hyperplastic and juvenile polyps were 43.84%, 42.09%, 11.06% and 1.51%, respectively.
  • Polypoid lesions were located at cecum 3.29%, ascending 11.88%, transverse 4.89%, descending 11.58%, sigmoid 26.05%, and rectum 42.32%.
  • The common pathological types were adenomatous and inflammatory polyps.

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  • (PMID = 16190400.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Park KJ, Choi HJ, Kim SH, Han SY, Hong SH, Cho JH, Kim HH: Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction. World J Gastroenterol; 2006 Jan 7;12(1):146-9
MedlinePlus Health Information. consumer health - Rectal Disorders.

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  • We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp.
  • The patient was a 56-year-old man who suffered from rectal bleeding for one day.
  • Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution.
  • An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum.
  • [MeSH-major] Adenoma / complications. Intussusception / surgery. Laparoscopy / methods. Rectal Diseases / surgery. Sigmoid Neoplasms / complications

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  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4077479
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38. Tanaka T: Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog; 2009;8:5

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  • The large majority of colorectal malignancies develop from an adenomatous polyp (adenoma).

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  • (PMID = 19332896.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2678864
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39. Liljegren A, Barker G, Elliott F, Bertario L, Bisgaard ML, Eccles D, Evans G, Macrae F, Maher E, Lindblom A, Rotstein S, Nilsson B, Mecklin JP, Möslein G, Jass J, Fodde R, Mathers J, Burn J, Bishop DT: Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. J Clin Oncol; 2008 Jul 10;26(20):3434-9
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  • PURPOSE: To determine the prevalence of adenomatous and hyperplastic polyps in a large cohort of individuals with a germline mutation in a mismatch repair (MMR) gene, the major genetic determinant of hereditary nonpolyposis colorectal cancer (HNPCC).
  • RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp.
  • No sex differences were found for either type of polyp.
  • CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent.

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
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  • (PMID = 18612159.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / A4994; United Kingdom / Medical Research Council / / G0100496; United Kingdom / Cancer Research UK / / ; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2645083
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40. Huang SC, Erdman SH: Pediatric juvenile polyposis syndromes: an update. Curr Gastroenterol Rep; 2009 Jun;11(3):211-9
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  • Colon polyps are a common finding in pediatrics and can present with rectal bleeding, abdominal pain, or polyp prolapse from the rectum.
  • Using a case-based format, this article reviews the clinical features and provides updates on the three most common hamartomatous polyp syndromes of childhood: juvenile polyposis syndrome, Peutz-Jeghers syndrome, and the PTEN hamartoma tumor syndrome.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Genetic Predisposition to Disease. Hamartoma / diagnosis. Peutz-Jeghers Syndrome / diagnosis

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  • (PMID = 19463221.001).
  • [ISSN] 1534-312X
  • [Journal-full-title] Current gastroenterology reports
  • [ISO-abbreviation] Curr Gastroenterol Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / SMAD4 protein, human; 0 / Smad4 Protein; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / BMPR1A protein, human; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.1.3.67 / PTEN protein, human
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41. Rajamanickam S, Velmurugan B, Kaur M, Singh RP, Agarwal R: Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin. Cancer Res; 2010 Mar 15;70(6):2368-78
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

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  • Silibinin feeding strongly prevented intestinal tumorigenesis in terms of polyp formation in proximal, middle, and distal portions of small intestine by 27% (P < 0.001), 34% (P < 0.001), and 49% (P < 0.001), respectively.

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  • (PMID = 20215518.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA112304-05; United States / NCI NIH HHS / CA / R01 CA112304; United States / NCI NIH HHS / CA / R01 CA112304-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Silymarin; 0 / beta Catenin; 136601-57-5 / Cyclin D1; 4RKY41TBTF / silybin; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
  • [Other-IDs] NLM/ NIHMS172766; NLM/ PMC2840193
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42. Hofstad B, Andersen SN, Nesbakken A: [Colorectal polyps]. Tidsskr Nor Laegeforen; 2007 Oct 18;127(20):2692-5
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • Pedunculated polyps are usually removed by endoscopical snare resection, which is sufficient even when cancer has developed in the head of the polyp.
  • Large sessile polyps, with considerable risk of malignancy, may be removed by transanal endoscopic microsurgery in the rectum, while surgical localised resection will often be required in the colon.
  • [MeSH-minor] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / surgery. Colonoscopy. Evidence-Based Medicine. Follow-Up Studies. Genetic Predisposition to Disease. Humans. Practice Guidelines as Topic. Risk Factors

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  • (PMID = 17952154.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 39
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43. Lièvre A, Milet J, Carayol J, Le Corre D, Milan C, Pariente A, Nalet B, Lafon J, Faivre J, Bonithon-Kopp C, Olschwang S, Bonaiti-Pellié C, Laurent-Puig P, members of the ANGH group: Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. BMC Cancer; 2006;6:270
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • To document the role of MMP polymorphisms in the early step of colorectal carcinogenesis, we investigated their association with colorectal adenoma risk in a case-control study comprising 295 patients with large adenomas (LA), 302 patients with small adenomas (SA) and 568 polyp-free (PF) controls.
  • [MeSH-major] Adenomatous Polyps / genetics. Colorectal Neoplasms / genetics. Matrix Metalloproteinase 1 / genetics. Matrix Metalloproteinase 3 / genetics. Matrix Metalloproteinase 7 / genetics. Polymorphism, Genetic / genetics

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  • (PMID = 17125518.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.7 / Matrix Metalloproteinase 1
  • [Other-IDs] NLM/ PMC1687194
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44. Leng Q, Wu KL, Jin HY, Liu P, Lin HP, Zhang JH, Ye H, Zhu Y, Zhang JC: [Distribution characteristics of colorectal neoplasm in 4450 patients and implication for colorectal cancer screening]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Nov;13(11):822-4
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • RESULTS: Colorectal neoplasm was found in 24.8% (4450/17,939) of the patients during colonoscopy, including adenomatous polyp (n=3410, 19.0%) and adenocarcinoma (n=1040, 5.8%).
  • 63.3% of the lesions located at the distal colon (sigmoid colon and rectum) and 36.7% at the proximal colon (36.7%).
  • In patients with adenomatous polyp, 52.8% (1802/3410) of the lesions were at the distal colon, 30.8% (1049/3410) at the proximal colon, and 16.4% (559/3410) at both distal and proximal colon.

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  • (PMID = 21108058.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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45. Bafandeh Y, Khoshbaten M, Eftekhar Sadat AT, Farhang S: Clinical predictors of colorectal polyps and carcinoma in a low prevalence region: results of a colonoscopy based study. World J Gastroenterol; 2008 Mar 14;14(10):1534-8
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • Adenomatous polyps were detected in 56 (11.7%) patients, in 12.3% of men and 10.9% of women.
  • The mean age of the patients with a polyp was significantly higher than the others (49.53 +/- 14.16 vs 41.85 +/- 16.26, P = 0.001).
  • Most of the adenomatous polyps were left sided and tubular; only 22.5% of polyps were more than 10 mm.
  • None of the symptoms (diarrhea, abdominal pain, rectal bleeding, constipation, altering diarrhea and constipation, history of cancer, known irritable bowel disease, history of polyp and fissure or family history of cancer) were predictors for cancer or polyps, but the age of the patient and unexplained anemia independently predicted cancer.

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  • (PMID = 18330943.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2693747
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46. Buchanan DD, Roberts A, Walsh MD, Parry S, Young JP: Lessons from Lynch syndrome: a tumor biology-based approach to familial colorectal cancer. Future Oncol; 2010 Apr;6(4):539-49
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  • The two most common epithelial lesions are the adenoma and the serrated polyp.
  • Lynch syndrome CRC arises almost exclusively within adenomatous precursor lesions, in contrast with familial serrated neoplasia where at least half of the cancers develop in serrated polyps.

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  • (PMID = 20373868.001).
  • [ISSN] 1744-8301
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA123010; United States / NCI NIH HHS / CA / R01 CA123010-01A1; United States / NCI NIH HHS / CA / U01 CA097735; United States / NCI NIH HHS / CA / 1R01CA123010
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Number-of-references] 70
  • [Other-IDs] NLM/ NIHMS207227; NLM/ PMC2896690
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47. Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K: T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res; 2009 Jul 1;69(13):5490-7
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  • Treg cells that expand in adenomatous polyps no longer produce IL-10 and instead switch to production of IL-17.
  • Aberrant Treg cells from polyp-ridden mice promote rather than suppress focal mastocytosis, a critical tumor-promoting inflammatory response.


48. Ruffin MT, Normolle DP, Evelegh MJ, Baron JA, Bresalier RS, Marcon NE, Syngal S, Turgeon DK, Tuck MK, Brenner DE: Rectal mucosal quantitative galactose oxidase-Schiff reaction as an early detection biomarker for colorectal cancer: comparison to fecal occult stool blood test. Cancer Biomark; 2010-2011;8(2):109-12
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  • [Title] Rectal mucosal quantitative galactose oxidase-Schiff reaction as an early detection biomarker for colorectal cancer: comparison to fecal occult stool blood test.
  • We completed a multi-center, prospective, cross-sectional cohort validation study consisting of 70 normal controls, 23 high-risk normal patients (polyp history or family history of colorectal cancer (CRC) with currently normal colonoscopy), 137 patients with adenomatous polyps, and 69 with colorectal cancers.
  • Prior to colonoscopy, two samples of stool were collected via a rectal exam: one for FOBT, and one for GOS.
  • [MeSH-major] Antigens, Viral, Tumor / analysis. Biomarkers, Tumor / analysis. Colorectal Neoplasms / diagnosis. Disaccharides / analysis. Galactans / analysis. Galactose Oxidase / chemistry. Intestinal Mucosa / chemistry. Rectum / chemistry

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  • (PMID = 21896998.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01 CA086400
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / Biomarkers, Tumor; 0 / Disaccharides; 0 / Galactans; 0 / Rosaniline Dyes; 0 / Schiff's reagent; 0 / galactosyll(1,3)-N-acetylgalactosamine; EC 1.1.3.9 / Galactose Oxidase
  • [Other-IDs] NLM/ NIHMS525881; NLM/ PMC4016824
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49. Lo SH, Law WL: Laparoscopic colorectal resection for polyps not suitable for colonoscopic removal. Surg Endosc; 2005 Sep;19(9):1252-5
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  • The histopathology of colorectal polyps showed tubular (n = 12), tubulovillous (n = 13), and villous adenoma (n = 12); mixed adenomatous/hyperolastic polyps (n = 2); inflammatory polyp (n = 1); and colonic lipoma (n = 1).
  • [MeSH-major] Colonic Polyps / surgery. Laparoscopy. Rectum / surgery

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  • (PMID = 16132333.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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50. Johnson CC, Hayes RB, Schoen RE, Gunter MJ, Huang WY, PLCO Trial Team: Non-steroidal anti-inflammatory drug use and colorectal polyps in the Prostate, Lung, Colorectal, And Ovarian Cancer Screening Trial. Am J Gastroenterol; 2010 Dec;105(12):2646-55
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  • OBJECTIVES: Non-steroidal anti-inflammatory drugs (NSAIDs) have been documented in animal and human studies to reduce risk for colorectal cancer and adenomatous polyps, but risk modification for subgroups of the population and effects on hyperplastic polyps have been less studied.
  • Cases (n=4,017) included subjects with a biopsy-proven polyp in the left side of the colon (descending colon, sigmoid, and rectum) detected as a consequence of PLCO screening; controls (n=38,396) were subjects with no left-sided colon polyp.
  • RESULTS: Regular use of aspirin (≥ 4 times/month) in the past year was inversely associated with hyperplastic polyps (odds ratios (OR)=0.8, 95% confidence interval (CI)=0.7-0.9), adenomatous polyps (OR=0.8, 95% CI=0.8-0.9), and advanced adenomas (OR=0.8, 95% CI=0.7-0.9).
  • Overall protection was consistent in both the descending colon or sigmoid and the rectum, but more evident in males.

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  • (PMID = 20808298.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / N01 CN25522; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; R16CO5Y76E / Aspirin; WK2XYI10QM / Ibuprofen
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51. Albright JB, Bonatti H, Stauffer J, Dickson RC, Nguyen J, Harnois D, Jeanpierre C, Hinder R, Steers J, Chua H, Aranda-Michel J: Colorectal and anal neoplasms following liver transplantation. Colorectal Dis; 2010 Jul;12(7):657-66
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  • Data on neoplasms of the colon, rectum and anus in LT are limited.
  • Post-LT adenomatous polyps were detected in 47.3% of patients with pre-LT polyps vs 6.7% of patients without pre-LT polyps (P < 0.001).
  • CONCLUSION: The incidence of metachronous and new polyp formation in our study is similar to people who are not immunocompromised, but subgroups are at increased risk.
  • Viral-associated malignancies, including post-transplant lymphoproliferative disorders and anal cancer, are important entities in the LT population suggesting that complete screening of the colon, rectum and anus including pre-LT and post-LT colonoscopy should be utilized.

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  • (PMID = 19508543.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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52. Jaszewski R, Misra S, Tobi M, Ullah N, Naumoff JA, Kucuk O, Levi E, Axelrod BN, Patel BB, Majumdar AP: Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial. World J Gastroenterol; 2008 Jul 28;14(28):4492-8
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  • AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps.
  • RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group.
  • The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group.

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  • (PMID = 18680228.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG014343
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
  • [Chemical-registry-number] 935E97BOY8 / Folic Acid
  • [Other-IDs] NLM/ PMC2731275
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