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1. Erdem L, Akbayir N, Yildirim S, Köksal HM, Yenice N, Gültekin OS, Sakiz D, Peker O: Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon. Turk J Gastroenterol; 2005 Dec;16(4):207-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon.
  • BACKGROUND/AIMS: Sigmoidoscopy is performed more frequently than colonoscopy, especially for screening purposes and searching for colorectal neoplasm.
  • METHODS: Patients found to have rectosigmoid adenomatous polyps on colonoscopy were included in the study.
  • These adenomas were grouped as diminutive (<or=5 mm), small (6-10 mm) or large (>or=11 mm) polyps.
  • RESULTS: In this study, of 1124 consecutive patients who underwent colonoscopy between April 1997 and January 2002, 184 (16%) had 258 adenomatous polyps in the rectosigmoid area.
  • The polyps were diminutive (<or=5 mm) in 105, small (6-10 mm) in 46 and large (>or=11 mm) in 33 patients.
  • Forty-one of the patients (39%) with diminutive polyps, 20 of the patients (43%) with small polyps and 19 of the patients (57%) with large polyps had neoplasm in the proximal bowel.
  • The rate of advanced proximal neoplasm was found to be significantly higher in the group with large polyps in the rectosigmoid area than in the groups with small and diminutive polyps (p<0.05).
  • In 104 patients (57%) with polyp(s) in rectum and sigmoid colon, no associated polyp or cancer was encountered in the proximal colon.
  • CONCLUSION: Colonoscopy is indicated when adenomatous polyp, regardless of size, is found on rectosigmoidoscopy performed because of symptoms.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neoplasms, Multiple Primary. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 16547849.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Turkey
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2. Lanza E, Yu B, Murphy G, Albert PS, Caan B, Marshall JR, Lance P, Paskett ED, Weissfeld J, Slattery M, Burt R, Iber F, Shike M, Kikendall JW, Brewer BK, Schatzkin A, Polyp Prevention Trial Study Group: The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization. Cancer Epidemiol Biomarkers Prev; 2007 Sep;16(9):1745-52
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  • [Title] The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization.
  • The Polyp Prevention Trial (PPT) was a multicenter randomized clinical trial to evaluate the effects of a high-fiber (18 g/1,000 kcal), high-fruit and -vegetable (3.5 servings/1,000 kcal), and low-fat (20% of total energy) diet on the recurrence of adenomatous polyps in the large bowel over a period of 4 years.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Colorectal Neoplasms / prevention & control. Diet. Neoplasm Recurrence, Local / prevention & control

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  • [CommentIn] Gastroenterology. 2008 Dec;135(6):2151 [19000679.001]
  • (PMID = 17855692.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
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3. Hartman TJ, Albert PS, Snyder K, Slattery ML, Caan B, Paskett E, Iber F, Kikendall JW, Marshall J, Shike M, Weissfeld J, Brewer B, Schatzkin A, Lanza E, Polyp Prevention Study Group: The association of calcium and vitamin D with risk of colorectal adenomas. J Nutr; 2005 Feb;135(2):252-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The association of calcium and vitamin D with risk of colorectal adenomas.
  • The Polyp Prevention Trial (PPT) was a multicenter randomized clinical trial designed to determine the effects of a high-fiber, high-fruit and vegetable, low-fat diet on the recurrence of adenomatous polyps in the large bowel.
  • We evaluated the association between calcium and vitamin D intake and adenomatous polyp recurrence after adjusting for intervention group, age, gender, nonsteroidal anti-inflammatory drug use, total energy intake, and the interaction of gender and intervention group.

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  • (PMID = 15671222.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 1406-16-2 / Vitamin D; SY7Q814VUP / Calcium
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4. Baxter N, Rabeneck L: New findings about the risks and limitations of colonoscopy used in the early detection of colorectal cancer. Healthc Q; 2009;12(2):24-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New findings about the risks and limitations of colonoscopy used in the early detection of colorectal cancer.
  • Colonoscopy has established benefits for the detection and prevention of colorectal cancer, which is the second leading cause of cancer-related deaths in Canada and the United States.
  • First, colonoscopy seems to be less effec-tive at preventing cancer deaths from tumours that originate in the right side of the large bowel.
  • Colonoscopy is widely used to detect both colorectal cancer and adenomatous polyps, which may become malignant if left alone.
  • During a complete colonoscopy, a physician - usually a gastroenterologist or general surgeon - inserts a long, flexible tube called a colonoscope through the patient's rectum and along the length of the large bowel.
  • If such a polyp or lesion is detected, it can often be removed during the colonoscopy so that no additional procedures or surgery are needed.
  • [MeSH-major] Colonoscopy / adverse effects. Colorectal Neoplasms / diagnosis

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  • (PMID = 19369808.001).
  • [ISSN] 1710-2774
  • [Journal-full-title] Healthcare quarterly (Toronto, Ont.)
  • [ISO-abbreviation] Healthc Q
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
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5. Sato Y, Nozaki R, Yamada K, Takano M, Haruma K: Relation between obesity and adenomatous polyps of the large bowel. Dig Endosc; 2009 Jul;21(3):154-7
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relation between obesity and adenomatous polyps of the large bowel.
  • BACKGROUND: We compared the prevalence of colorectal adenoma (polyps) in men and women and examined the role of body mass index (BMI) on polyp risk according to patient age and gender.
  • METHODS: The risk of developing colorectal polyps was studied in 15 380 subjects (7155 men and 8225 women) who underwent colonoscopy for the first time from April 1998 to March 2006 at our 'Human Dry Dock', which is the check-up service provided in Japan.
  • RESULTS: The OR of polyp detection in obese subjects (BMI >or= 25) versus non-obese subjects (BMI < 25, OR = 1) was 1.34 (P < 0.001) in men and 1.13 (P = 0.26) in women.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology

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  • (PMID = 19691761.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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6. Tanaka T: Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog; 2009;8:5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colorectal carcinogenesis: Review of human and experimental animal studies.
  • This review gives a comprehensive overview of cancer development and links it to the current understanding of tumorigenesis and malignant progression in colorectal cancer.
  • The focus is on human and murine colorectal carcinogenesis and the histogenesis of this malignant disorder.
  • The earliest phases of colorectal oncogenesis occur in the normal mucosa, with a disorder of cell replication.
  • The large majority of colorectal malignancies develop from an adenomatous polyp (adenoma).
  • Besides adenomas, there are other types of pre-neoplasia, which include hyperplastic polyps, serrated adenomas, flat adenomas and dysplasia that occurs in the inflamed colon in associated with inflammatory bowel disease.
  • Colorectal neoplasms cover a wide range of pre-malignant and malignant lesions, many of which can easily be removed during endoscopy if they are small.
  • Colorectal neoplasms and/or pre-neoplasms can be prevented by interfering with the various steps of oncogenesis, which begins with uncontrolled epithelial cell replication, continues with the formation of adenomas and eventually evolves into malignancy.

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  • (PMID = 19332896.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2678864
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7. Wong RF, Tuteja AK, Haslem DS, Pappas L, Szabo A, Ogara MM, DiSario JA: Video capsule endoscopy compared with standard endoscopy for the evaluation of small-bowel polyps in persons with familial adenomatous polyposis (with video). Gastrointest Endosc; 2006 Oct;64(4):530-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Video capsule endoscopy compared with standard endoscopy for the evaluation of small-bowel polyps in persons with familial adenomatous polyposis (with video).
  • BACKGROUND: Video capsule endoscopy (VCE) may be useful for surveillance of small-bowel polyps in patients with familial adenomatous polyposis (FAP).
  • OBJECTIVE: To compare VCE to standard endoscopy for diagnosing small-bowel polyps in a defined segment of small bowel (proximal to a tattoo) and the entire examined small bowel.
  • The majority were selected for their high number of proximal small-bowel polyps and prior endoscopic tattoo placement in the proximal small bowel.
  • INTERVENTIONS: VCE (interpreted by 2 readers), push enteroscopy (PE), and lower endoscopy (LE) to count and measure small-bowel polyps.
  • Agreement between VCE and PE was poor to fair (kappa = 0.10, 0.22) for estimating the size of the largest polyp and poor (kappa = -0.20, -0.27) for detecting large polyps (> or =1 cm).
  • In the entire examined small bowel, VCE diagnosed a median of 38.0 (IQR, 10.5-71.5) and 54.0 (IQR, 13.0-100.0) polyps for each reader compared with a median of 123.0 (IQR, 38.5-183.0) for combination endoscopy (PE and LE) (P < .001).
  • LIMITATIONS: Participants selected for high polyp burden, and results may not be applicable to all patients with FAP.
  • CONCLUSIONS: VCE underestimates the number of small-bowel polyps in persons with FAP and does not reliably detect large polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Capsule Endoscopy. Duodenal Neoplasms / diagnosis. Endoscopy, Gastrointestinal. Jejunal Neoplasms / diagnosis

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  • [CommentIn] Gastrointest Endosc. 2007 Sep;66(3):634; author reply 634-5 [17725961.001]
  • (PMID = 16996344.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01RR00064; United States / NCI NIH HHS / CA / R01 CA80852-05
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, Lines C, Riddell R, Morton D, Lanas A, Konstam MA, Baron JA, Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators: Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med; 2005 Mar 17;352(11):1092-102
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  • [Title] Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.
  • We report on the cardiovascular outcomes associated with the use of the selective COX-2 inhibitor rofecoxib in a long-term, multicenter, randomized, placebo-controlled, double-blind trial designed to determine the effect of three years of treatment with rofecoxib on the risk of recurrent neoplastic polyps of the large bowel in patients with a history of colorectal adenomas.
  • METHODS: A total of 2586 patients with a history of colorectal adenomas underwent randomization: 1287 were assigned to receive 25 mg of rofecoxib daily, and 1299 to receive placebo.
  • CONCLUSIONS: Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Cardiovascular Diseases / chemically induced. Colorectal Neoplasms / prevention & control. Cyclooxygenase Inhibitors / adverse effects. Lactones / adverse effects. Sulfones / adverse effects. Thrombosis / chemically induced


9. Wong NA, Hunt LP, Novelli MR, Shepherd NA, Warren BF: Observer agreement in the diagnosis of serrated polyps of the large bowel. Histopathology; 2009 Jul;55(1):63-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Observer agreement in the diagnosis of serrated polyps of the large bowel.
  • AIMS: To assess observer agreement in the diagnosis of colorectal serrated polyps, in particular, serrated adenomas and admixed polyps (i.e.
  • 'polyps with admixed hyperplastic and adenomatous glands').
  • METHODS AND RESULTS: Sixty cases of large bowel polyps were assessed by four specialist gastrointestinal histopathologists and allocated into one of five categories: serrated adenoma, hyperplastic polyp, conventional adenoma, admixed polyp, and other polyps with serration.
  • The kappa values for diagnosing serrated adenoma versus all other polyps, and admixed polyp versus all other polyps were 0.38 and 0.3, respectively.
  • CONCLUSIONS: Specialist gastrointestinal histopathologists show only moderate concordance when distinguishing between serrated colorectal polyps.
  • There is only fair interobserver agreement in the diagnosis of serrated adenomas and admixed polyps of the large bowel.

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  • (PMID = 19614768.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Voloyiannis T, Snyder MJ, Bailey RR, Pidala M: Management of the difficult colon polyp referred for resection: resect or rescope? Dis Colon Rectum; 2008 Mar;51(3):292-5
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  • [Title] Management of the difficult colon polyp referred for resection: resect or rescope?
  • Before colectomy the experienced surgeon has the option of repeating the colonoscopy to assess the polyp, tattoo the site, and potentially remove the polyp.
  • METHODS: All new patients referred during a five-year period to an 11-physician colon and rectal surgical group with the diagnosis of colon polyp (CPT 211.3) that was not previously removed were retrospectively reviewed.
  • Patients with rectal polyps, inflammatory bowel disease, previous cancer, or familial adenomatous polyposis were excluded.
  • A total of 172 patients underwent at least one repeat colonoscopy by the colorectal surgeon.
  • In 26 cases the polyp site was tattooed for later localization.
  • Patients with large difficult polyps referred for resection should be considered for repeat colonoscopy before surgery.

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  • [ErratumIn] Dis Colon Rectum. 2008 Aug;51(8):1300
  • (PMID = 18202891.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Avanesian AA, Shcherbakov AM: [An experience with clinical endoscopy and argon-plasma coagulation for removal of large bowel polyps]. Vopr Onkol; 2005;51(5):592-4
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  • [Title] [An experience with clinical endoscopy and argon-plasma coagulation for removal of large bowel polyps].
  • Polyp diameter ranged 1.0-1.9 cm (12 adenomas), 2-2.9 (18) or 3-5 cm (21).
  • Coagulation was carried out immediately after partial removal of polyp with the aid of diathermic loop.
  • That technique proved more effective and safer than traditional methods in dealing with large polyps of the large bowel having a wide pedicle and/or sprawling.
  • [MeSH-minor] Adenomatous Polyposis Coli / surgery. Adult. Aged. Aged, 80 and over. Argon / therapeutic use. Female. Follow-Up Studies. Humans. Male. Middle Aged. Plasma. Retrospective Studies. Treatment Outcome

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  • (PMID = 16756019.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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12. Will OC, Leedham SJ, Elia G, Phillips RK, Clark SK, Tomlinson IP: Location in the large bowel influences the APC mutations observed in FAP adenomas. Fam Cancer; 2010 Sep;9(3):389-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Location in the large bowel influences the APC mutations observed in FAP adenomas.
  • In both sporadic colorectal cancer and Familial Adenomatous Polyposis (FAP), polyp density and cancer susceptibility vary markedly by colonic site.
  • The higher frequency of LOH in rectal polyps from patients with codon 1309 mutations may help to explain their increased polyp burden at this site compared with patients who have other germline APC mutations.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Genes, APC. Intestine, Large / pathology

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  • (PMID = 20229069.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / beta Catenin; EC 3.4.22.- / Caspase 3
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13. John BJ, Irukulla S, Pilgrim G, Swift I, Abulafi AM: Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital. Colorectal Dis; 2008 Nov;10(9):898-900
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital.
  • INTRODUCTION: The British society of Gastroenterologists (BSG) have laid down guidelines for surveillance colonoscopies in patients with large bowel adenomatous polyps.
  • We audited our practice of polyp management and looked at guideline compliance amongst patients on our colonoscopic surveillance list.
  • The BSG guidelines were printed, laminated and displayed in the colorectal clinics.
  • Of the patients on our colonoscopic waiting list for adenomatous polyps, 17.7% satisfied guidelines, 23.4% did not require any further surveillance and 58.9% were booked for a procedure earlier than recommended.

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  • (PMID = 19037930.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Will OC, Robinson J, Günther T, Phillips RK, Clark SK, Tomlinson I: APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps. Br J Surg; 2008 Jun;95(6):765-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps.
  • BACKGROUND: Ileoanal pouch polyps commonly develop following restorative proctocolectomy in patients with familial adenomatous polyposis (FAP).
  • In FAP adenomas, the relationship between germline and somatic adenomatous polyposis coli (APC) mutations is determined by 'just right' beta-catenin signalling in tumour cells, with respect to the 20-amino acid beta-catenin-binding/degradation repeats (20AARs) in the APC protein.
  • The aim of this study was to establish the mutational spectrum in ileoanal pouch polyps, to ascertain whether polyp development resembled that typical of small or large bowel.
  • This was significantly fewer than in upper gastrointestinal polyps, and more than in colorectal adenomas.
  • CONCLUSION: Tissue environment appears to influence the position of the 'second hit' in pouch polyps and the mutations resemble those of large bowel polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colonic Pouches. Genes, APC. Germ-Line Mutation / genetics. Intestinal Polyps / genetics

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  • [Copyright] 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 18418860.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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15. Colakoglu T, Yildirim S, Kayaselcuk F, Nursal TZ, Ezer A, Noyan T, Karakayali H, Haberal M: Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? Am J Surg; 2008 Jun;195(6):719-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?
  • The relation between PTEN expression and Akt activation is still unclear in colorectal cancers and adenomatous polyps.
  • METHODS: PTEN and pAkt expression were evaluated in 76 primary colorectal cancers and 25 adenomatous colorectal polyp tissues using immunohistochemical staining on paraffin-embedded sections.
  • PTEN and pAkt expression were compared with clinicopathologic features of colorectal cancers.
  • RESULTS: In colorectal cancers, pAkt expression was found to be significantly higher than polyps (P = .007).
  • In colorectal cancer patients, PTEN expression showed a negative correlation with young age, female sex, and left-sided (distal) tumors.
  • There was significant association between pAkt expression and stage (P = .008), and preoperative serum carcinoembryonic antigen (CEA) levels (P = .017) in colorectal cancers.
  • A negative correlation between PTEN and pAkt expression was found in colon cancer patients (P = .010), whereas no significiant association was found in adenomatous polyps (P = .403).
  • CONCLUSIONS: The current study suggests that the PTEN loss-PI3K/pAkt pathway may play an important role in sporadic colon carcinogenesis and that reduced PTEN expression may predict relapse in colorectal cancer patients.
  • [MeSH-major] Adenocarcinoma / metabolism. Colorectal Neoplasms / metabolism. Neoplasm Recurrence, Local. PTEN Phosphohydrolase / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Signal Transduction
  • [MeSH-minor] Adenomatous Polyps / genetics. Adenomatous Polyps / metabolism. Adult. Aged. Aged, 80 and over. Female. Gene Expression. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18440486.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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16. Baron JA: Aspirin and NSAIDs for the prevention of colorectal cancer. Recent Results Cancer Res; 2009;181:223-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aspirin and NSAIDs for the prevention of colorectal cancer.
  • With few exceptions, epidemiological studies have found that individuals who take nonsteroidal antiinflammatory drugs (NSAIDs) have a reduced risk of colorectal adenomas and carcinoma.
  • Similarly, randomized studies in patients with familial adenomatous polyposis have uniformly found that NSAIDs can lead to polyp regression and prevention of new polyps, and trials in patients with sporadic adenomas document that aspirin reduces the risk of adenoma recurrence.
  • Together these data provide convincing evidence for the chemopreventive efficacy ofNSAIDs in the large bowel.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / therapeutic use. Colorectal Neoplasms / prevention & control

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  • (PMID = 19213572.001).
  • [ISSN] 0080-0015
  • [Journal-full-title] Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
  • [ISO-abbreviation] Recent Results Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; R16CO5Y76E / Aspirin
  • [Number-of-references] 35
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17. Zurac S, Micu G, Bastian A, Grămadă E, Lavric L, Andrei R, Stăniceanu F, Voiosu R, Croitoru A: Malignancy and overdiagnosis of malignancy in Peutz Jeghers polyposis. Rom J Intern Med; 2008;46(2):179-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two of these cases were related (mother and daughter); both of them were operated in another hospital for small bowel tumors with a subsequent diagnosis of adenocarcinoma.
  • The daughter (28 years old) was referred to our hospital for endoscopic follow-up; a small polyp of the transverse large bowel was excised by colonoscopy with a histopathologic diagnosis of PJ polyp; a careful histopathologic reevaluation of both specimens of enterectomy (slides and paraffin blocks) revealed an overdiagnosis of cancer due to the epithelial cystic dilatation and pseudoinvasion in both patients.
  • The other case showed diagnostic changes of PJS and also various aspects of adenomatous polyps some of them with mild and moderate dysplastic changes.
  • When a PJ polyp is diagnosed, the possibility of pseudoinvasion should be kept in mind, in order to avoid overdiagnosis of malignancy; also, due to the fact that the malignant transformation of a PJ polyp is still on debate (hamartoma-dysplasia-carcinoma sequence versus malignant transformation of an adenomatous aria of a hamartoma versus coincidental association of a digestive cancer due to genetic aberrations of PJS), all the other associated microscopic aspects of the lesion should be carefully analyzed.

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  • (PMID = 19284092.001).
  • [ISSN] 1220-4749
  • [Journal-full-title] Romanian journal of internal medicine = Revue roumaine de médecine interne
  • [ISO-abbreviation] Rom J Intern Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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18. Baron JA, Sandler RS, Bresalier RS, Lanas A, Morton DG, Riddell R, Iverson ER, Demets DL: Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet; 2008 Nov 15;372(9651):1756-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The Adenomatous Polyp Prevention on Vioxx (APPROVe) study assessed the effect of 3-year treatment with a cyclo-oxygenase-2 inhibitor, rofecoxib (25 mg), on recurrence of neoplastic polyps of the large bowel.
  • 2587 patients with a history of colorectal adenomas were recruited at 108 centres worldwide during 2000 and 2001.
  • [MeSH-minor] Colorectal Neoplasms / prevention & control. Data Interpretation, Statistical. Double-Blind Method. Female. Follow-Up Studies. Humans. Male. Middle Aged

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  • [CommentIn] Lancet. 2008 Nov 15;372(9651):1712-3 [18922571.001]
  • [CommentIn] Evid Based Med. 2009 Aug;14(4):111 [19648427.001]
  • [ErratumIn] Lancet. 2008 Nov 15;372(9651):1732
  • (PMID = 18922570.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00282386
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Lactones; 0 / Sulfones; 0QTW8Z7MCR / rofecoxib
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19. Rock CL: Primary dietary prevention: is the fiber story over? Recent Results Cancer Res; 2007;174:171-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colorectal cancer is a major cause of morbidity in developed countries, and epidemiological and experimental research suggests that environmental factors, particularly diet, may play a key etiologic role.
  • Among the various dietary factors that have been proposed to affect the risk and progression of colon cancer, dietary fiber has been of greatest interest, due to the effects of fiber on the function of the large bowel.
  • Several case-control studies and a few cohort studies have linked higher fiber intake to reduced risk for colorectal cancer, although the results of these observational studies have been inconsistent.
  • In the large European Prospective Investigation into Cancer and Nutrition observational study, higher dietary fiber from foods was associated with an estimated 25% reduction in risk for large bowel cancer.
  • However, no significant relationship between fiber intake (or major food sources of fiber) and risk for colorectal cancer was observed in a recently reported large pooled analysis of several cohort studies.
  • To date, intervention studies testing the relationship between dietary fiber and colon cancer have focused on whether fiber supplementation or diet modification can affect the risk for adenoma recurrence and growth in individuals with a history of adenomatous polyps.
  • In a large randomized U.S. study, the Polyp Prevention Trial, the effect of prescribing diet modification (increased fiber and reduced fat intakes) was tested, and no effects on adenoma recurrence were observed, although dietary biomarker data suggest that the change in dietary intakes in the intervention arm was not substantial.
  • The effect of increased dietary fiber intake on risk for colorectal cancer has not been adequately addressed in studies conducted to date.
  • [MeSH-major] Colorectal Neoplasms / diet therapy. Colorectal Neoplasms / prevention & control. Dietary Fiber / therapeutic use. Primary Prevention / methods

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  • (PMID = 17302194.001).
  • [ISSN] 0080-0015
  • [Journal-full-title] Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
  • [ISO-abbreviation] Recent Results Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 32
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20. Hudson TS, Forman MR, Cantwell MM, Schatzkin A, Albert PS, Lanza E: Dietary fiber intake: assessing the degree of agreement between food frequency questionnaires and 4-day food records. J Am Coll Nutr; 2006 Oct;25(5):370-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: At baseline and year one, all participants in the Polyp Prevention Trial (PPT), a multi-center randomized, clinical trial of a low-fat, high fiber, high fruit/vegetable eating plan and recurrence of large bowel adenomatous polyps were instructed in dietary assessment and completed a 106-item FFQ and 4DFR that trained nutritionists reviewed.

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  • (PMID = 17031005.001).
  • [ISSN] 0731-5724
  • [Journal-full-title] Journal of the American College of Nutrition
  • [ISO-abbreviation] J Am Coll Nutr
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Validation Studies
  • [Publication-country] United States
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21. Hayes SJ: Assessment of colorectal adenomatous polyp size measured during pathological examination highlights the importance of accuracy. Gastrointest Endosc; 2009 Sep;70(3):540-1
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of colorectal adenomatous polyp size measured during pathological examination highlights the importance of accuracy.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
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  • (PMID = 19555943.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] United States
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22. Jiménez-Heffernan JA, Tejerina E, de la Morena E, Sanz Ortega E: Gamna-Gandy bodies in an adenomatous colorectal polyp. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):876-7
MedlinePlus Health Information. consumer health - Minerals.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamna-Gandy bodies in an adenomatous colorectal polyp.
  • [MeSH-major] Colorectal Neoplasms / pathology. Minerals / analysis. Polyps / pathology

  • MedlinePlus Health Information. consumer health - Colorectal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21045462.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Minerals
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