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1. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • [Title] Analysis of mtDNA sequence variants in colorectal adenomatous polyps.
  • Colorectal tumors mostly arise from sporadic adenomatous polyps.
  • Polyps are defined as a mass of cells that protrudes into the lumen of the colon.
  • Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia.
  • It has been shown that polyps were benign tumors which may undergo malignant transformation.
  • Adenomatous polyps have been classified into three histologic types; tubular, tubulovillous, and villous with increasing malignant potential.
  • The ability to differentially diagnose these colorectal adenomatous polyps is important for therapeutic intervention.
  • To date, little efforts have been directed to identifying genetic changes involved in adenomatous polyps.
  • This study was designed to examine the relevance of mitochondrial genome alterations in the three adenomatous polyps.
  • Using high resolution restriction endonucleases and PCR-based sequencing, fifty-seven primary fresh frozen tissues of adenomatous polyps (37 tumors and 20 matched surrounding normal tissues) obtained from the southern regional Cooperative Human Tissue Network (CHTN) and Grady Memorial Hospital at Atlanta were screened with three mtDNA regional primer pairs that spanned 5.9 kbp.
  • Notably, a heteroplasmic variant C8515G/T in the MT-ATP 8 gene and a germline variant 8327delA in the tRNAlys was observed in all the tissue samples of the three adenomatous polyps in comparison to the referenced database sequence.
  • Our current data provide a basis for continued investigation of certain mtDNA variants as predictors of the three adenomatous polyps in a larger number of clinicopathological specimens.
  • [MeSH-major] Adenomatous Polyps / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Mitochondrial / analysis. Genetic Variation
  • [MeSH-minor] Aged. Biopsy. DNA Mutational Analysis. Databases, Genetic. Disease Progression. Humans. Middle Aged. Polymerase Chain Reaction. Prognosis

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  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
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2. Ihtiyar E, Algin C, Isiksoy S, Ates E: Small cell carcinoma of rectum: a case report. World J Gastroenterol; 2005 May 28;11(20):3156-8
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  • By colonoscopy, polyps were determined in the rectum and biopsies were carried out.
  • Histopathologically, the polyps were adenomatous.

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  • (PMID = 15918209.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4305859
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3. Xu HX: Contrast-enhanced ultrasound in the biliary system: Potential uses and indications. World J Radiol; 2009 Dec 31;1(1):37-44

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  • The use of contrast-enhanced US (CEUS) has reached the field of bile duct disease in recent years and promising results have been achieved.
  • (4) To detect malignant change in Caroli's disease;.
  • (6) To make a distinction between gallbladder cholesterol polyp, adenoma and polypoid cancer;.

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  • (PMID = 21160719.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999303
  • [Keywords] NOTNLM ; Bile duct / Cholangiocarcinoma / Contrast-enhanced ultrasound / Gallbladder / Polypoid lesion / Ultrasound contrast agent
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4. Summers RM, Liu J, Yao J, Brown L, Choi JR, Pickhardt PJ: Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps. AJR Am J Roentgenol; 2009 Nov;193(5):1305-10
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  • [Title] Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps.
  • OBJECTIVE: Hyperplastic polyps are more difficult to detect than adenomatous polyps at CT colonography (CTC), and it has been theorized that this difference in detectability is because hyperplastic polyps are flatter.
  • Using automated software that computes polyp height, we determined whether hyperplastic colonic polyps on CTC are indeed flatter than adenomatous polyps of comparable width.
  • One hundred eighty-five of the patients had at least one hyperplastic or adenomatous polyp 6-10 mm visible at both OC and CTC, where size was determined by a calibrated guidewire at OC.
  • To assess flatness, the heights of the polyps at CTC were measured using a validated automated software program.
  • The heights and height-to-width ratios of the hyperplastic polyps were compared with those of the adenomatous polyps using a Student's t test (two-tailed, unpaired, unequal variance).
  • RESULTS: There were 176 adenomatous and 83 hyperplastic polyps visible at segment-unblinded OC.
  • The fraction of these polyps that were measurable at CTC using the automated software was not significantly different for adenomatous versus hyperplastic polyps (158/176 [89.8%] vs 73/87 [83.9%], respectively; p = 0.2).
  • The average height-to-width ratios using automated width measurements were 15% less for hyperplastic polyps: 0.39 +/- 0.20 (n = 158) and 0.33 +/- 0.19 (n = 73) for adenomatous and hyperplastic polyps, respectively (p = 0.03).
  • When polyps of comparable OC size or CTC width were considered, the heights of hyperplastic polyps were up to 27% less than those of adenomatous polyps.
  • CONCLUSION: For 6-10 mm polyps of a given size as determined by OC or a given width at CTC, hyperplastic polyps tend to be flatter (i.e., have lower height) compared with adenomatous polyps.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic. Radiographic Image Interpretation, Computer-Assisted / methods
  • [MeSH-minor] Adenomatous Polyps / pathology. Adenomatous Polyps / radiography. Aged. Analysis of Variance. Automation. Colonoscopy. Contrast Media. Female. Humans. Hyperplasia. Male. Middle Aged. Retrospective Studies. Software

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  • (PMID = 19843746.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-05; United States / Intramural NIH HHS / / Z01 CL040003-06; United States / Intramural NIH HHS / / ZIA CL040003-07; United States / Intramural NIH HHS / / ZIA CL040003-08; United States / Intramural NIH HHS / / ZIA CL040003-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ NIHMS394801; NLM/ PMC3412299
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5. Powers HJ, Hill MH, Welfare M, Spiers A, Bal W, Russell J, Duckworth Y, Gibney E, Williams EA, Mathers JC: Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study). Cancer Epidemiol Biomarkers Prev; 2007 Oct;16(10):2128-35
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  • [Title] Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).
  • A double-blind randomized placebo-controlled intervention study (the FAB2 Study) was carried out in healthy controls and patients with colorectal polyps (adenomatous and hyperplastic) to examine effects of folic acid and riboflavin supplements on biomarkers of nutrient status and on putative biomarkers of colorectal cancer risk (DNA methylation and DNA damage; to be reported elsewhere).
  • Ninety-eight healthy controls and 106 patients with colorectal polyps were stratified for the thermolabile variant of methylene tetrahydrofolate reductase, MTHFR C677T, and were randomized to receive 400 microg of folic acid, 1,200 microg of folic acid, or 400 microg of folic acid plus 5 mg of riboflavin or placebo for 6 to 8 weeks.
  • Riboflavin supplement enhanced the response to low-dose folate in people carrying at least one T allele and having polyps.
  • The magnitude of the response in mucosal folate was positively related to the increase in plasma 5-methyl tetrahydrofolate but was not different between the healthy group and polyp patients.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Biomarkers, Tumor / blood. Folic Acid / administration & dosage. Folic Acid / blood. Riboflavin / administration & dosage. Riboflavin / blood

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  • (PMID = 17932361.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tetrahydrofolates; 0LVT1QZ0BA / Homocysteine; 134-35-0 / 5-methyltetrahydrofolate; 935E97BOY8 / Folic Acid; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); TLM2976OFR / Riboflavin
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6. Liu YH, Lin J, Guo J, You ZJ, Wang ZG, Zhong D, Yang XL, Zhang ZS, Xiao B, Guo WY: [Detection of interferon-induced transmembrane-1 gene expression for clinical diagnosis of colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Nov;28(11):1950-3
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  • METHODS: Semi-quantitative RT-PCR was performed to detect IFITM1 mRNA expression in the specimens of normal colonic mucosa, CRC tissue, inflammatory polyps, adenomatous polyps, gastric cancer, esophageal carcinoma and liver cancer tissues.
  • RESULTS: IFITM1 mRNA was expressed in 47.4 % (18/38) of the CRC specimens, a rate significantly higher than that in adenomatous polyps [15% (3/20)] and gastric cancer [4.8% (1/21)]; no obvious IFITM1 expression was found in normal colonic mucosa, inflammatory polyp, esophageal carcinoma or liver cancer tissues (P<0.001 or P<0.05).
  • IFITM1 mRNA was strongly expressed in CRC at the expression level of 0.8048-/+0.2273, which was significantly higher than that in adenomatous polyps (0.4447-/+0.0989, P<0.001).
  • No antibody response was detected in esophageal carcinoma, liver cancer, inflammatory polyp or adenomatous polyps.

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  • (PMID = 19033100.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Differentiation; 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / leu-13 antigen
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7. Arber N, Eagle CJ, Spicak J, Rácz I, Dite P, Hajer J, Zavoral M, Lechuga MJ, Gerletti P, Tang J, Rosenstein RB, Macdonald K, Bhadra P, Fowler R, Wittes J, Zauber AG, Solomon SD, Levin B, PreSAP Trial Investigators: Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med; 2006 Aug 31;355(9):885-95
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  • [Title] Celecoxib for the prevention of colorectal adenomatous polyps.
  • BACKGROUND: Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention.
  • METHODS: The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, placebo-controlled, double-blind study of the COX-2 inhibitor celecoxib given daily in a single 400-mg dose.
  • Of the 557 subjects in the placebo group and the 840 subjects in the celecoxib group who were included in the efficacy analysis, 264 and 270, respectively, were found to have at least one adenoma at year 1, at year 3, or both.
  • [MeSH-major] Adenoma / prevention & control. Adenomatous Polyps / drug therapy. Colorectal Neoplasms / prevention & control. Cyclooxygenase 2 Inhibitors / therapeutic use. Pyrazoles / therapeutic use. Sulfonamides / therapeutic use

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  • [Copyright] Copyright 2006 Massachusetts Medical Society.
  • [CommentIn] N Engl J Med. 2006 Nov 30;355(22):2371; author reply 2371-3 [17135594.001]
  • [CommentIn] N Engl J Med. 2006 Aug 31;355(9):950-2 [16943408.001]
  • (PMID = 16943401.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00141193
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib; R16CO5Y76E / Aspirin
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8. Kil Lee S, Il Kim T, Kwan Shin S, Ho Kim W, Kim H, Kyu Kim N: Comparison of the clinicopathologic features between flat and polypoid adenoma. Scand J Gastroenterol; 2008;43(9):1116-21
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  • [Title] Comparison of the clinicopathologic features between flat and polypoid adenoma.
  • OBJECTIVE: Several reports have suggested that flat colorectal adenomas might exhibit a higher potential for malignancy compared to polypoid adenomas.
  • Although the clinical importance of the shape of polyps is stressed, the controversy surrounding the malignant potential of flat adenomas continues.
  • The aim of this study was to compare the clinicopathologic characteristics, including degree of dysplasia and malignancy, between flat and polypoid adenomas 5 mm in size or larger.
  • MATERIAL AND METHODS: A total of 3263 polyps (254 flat adenomas and 3009 polypoid adenomas), >/=5 mm in size, diagnosed in 1883 patients by colonoscopy were analyzed.
  • The flat adenomas were larger in diameter than the polypoid adenomas (14.8+/-12.6 mm versus 8.6+/-5.0 mm, p <0.01), had a higher rate of villous components (18.5% versus 11.4%, p <0.01), a higher rate of high-grade dysplasia (9.4% versus 4.2%, p <0.01), and a higher rate of malignancy (10.2% versus 3.6%, p <0.01) than polypoid adenomas.
  • However, there was no difference in the rate of high-grade dysplasia or carcinoma between flat and polypoid adenomas of equal size.
  • It was shown by multivariate analysis that rectosigmoid location, larger size, and presence of a villous component were associated with a higher rate of malignancy, but not with flat morphology.
  • CONCLUSIONS: Flat adenomas, which were of a relatively large size in this study, were not associated with a higher risk for high-grade dysplasia and carcinoma compared with polypoid adenomas.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 18609172.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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9. Speake D, Biyani D, Frizelle FA, Watson AJ: Flat adenomas. ANZ J Surg; 2007 Jan-Feb;77(1-2):4-8
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  • The adenoma-carcinoma sequence describes a succession of events from polypoid adenoma to colorectal cancer.
  • There is growing evidence that flat adenomas are precursor lesions to a flat type of colorectal cancer and certain subtypes of these polyps are at greater risk of malignant transformation.
  • [MeSH-major] Adenocarcinoma / physiopathology. Adenoma / physiopathology. Colonic Neoplasms / physiopathology. Colonic Polyps / physiopathology

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  • (PMID = 17295810.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 72
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10. Tao S, Lu Q, Jiang B: [The clinical significance of colorectal flat lesions under endoscopy]. Zhonghua Yi Xue Za Zhi; 2007 May 29;87(20):1417-9
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  • OBJECTIVE: To identify flat lesion in colon and rectum with combination of magnifying endoscope and mucosa staining technique ad to compare the differences between the protruded and flat colorectal lesions.
  • (1) A total of 1472 adenoma cases were found; 154 (10.46%) of which were of the flat type. (2) The average size of flat adenoma was (17 +/- 14) mm, significantly smaller than that of polypoid adenoma [(29 +/- 9) mm, P < 0.05)]. (3) The incidence of colorectal tumor in the left colon was 82.35% (140/170) in the flat type tumor, significantly higher than that in the protruded type tumors (79.59%, 1630/2048, P = 0.013). (4) The incidence rates of tubular adenoma, tubulo-villous adenoma, villous adenoma, and cancer were 51.34%, 4.25%, 8.79%, and 35.65% respectively in the protruded type tumor, and were 55.55%, 17.06%, 17.64%, and 9.43% respectively.
  • CONCLUSION: The detection rates of moderate and severe dysplasia and early colorectal cancer in the flat adenomas are higher than in the protruded adenoma.
  • Of higher malignancy grade, flat adenomatous lesions are more likely to be carcinomatous compared with the protruded adenomatous lesions.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / epidemiology. Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / epidemiology. Adolescent. Adult. Aged. Aged, 80 and over. China / epidemiology. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Diagnosis, Differential. Humans. Incidence. Middle Aged

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  • (PMID = 17785067.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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11. Parra V, Watanabe J, Nago A, Astete M, Rodríguez C, Valladares G, Nuñez N, Yoza M, Gargurevich T, Pinto Sánchez J: [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy]. Rev Gastroenterol Peru; 2009 Oct-Dec;29(4):326-31
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  • [Title] [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy].
  • [Transliterated title] Papel del Endoscopista en la Detección de Pólipos Adenomatosos Durante la Colonoscopia.
  • INTRODUCTION: Age, gender and indication for the examination are known predictors of adenomatous polyp detection during colonoscopy.
  • OBJECTIVES: To determine the role of the endoscopist in detecting adenomatous polyps during colonoscopy MATERIAL AND METHODS: Is retrospective cross-sectional correlational study.
  • Statistical analysis showed significant differences between endoscopists regarding the detection rate of adenomatous polyps (p = 0.038).
  • The range for the detection of at least 1 adenomatous polyp by colonoscopy was 14,6-30,0%.
  • In patients over 50 years, there were also significant differences between endoscopists in detection rate of adenomatous polyps (p = 0.001).
  • The range for the detection of at least 1 adenomatous polyp was 18,2-37,5% in that group.Also found that age and gender were powerful predictors of adenomatous polyps, both for the total cohort, and patients older than 50 years.
  • Regarding the indication for colonoscopy, no significant difference between the categories, were found p = 0.288 CONCLUSION S: The endoscopist is as or more important than age, gender or indication for the examination, in predicting the detection of adenomatous polyps during colonoscopy.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonoscopy / standards

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  • (PMID = 20066017.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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12. Parfitt JR, Shepherd NA: Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp! Histopathology; 2008 Jul;53(1):91-6
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  • [Title] Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp!
  • AIMS: Polypoid mucosal prolapse near the anorectal junction mimics adenomas endoscopically and histopathologically.
  • The aim was to describe the phenomenon of polypoid mucosal prolapse arising secondary to adenomas at the anorectal junction.
  • METHODS AND RESULTS: Four cases of low rectal adenoma with polypoid mucosal prolapse were assessed histopathologically, as well as with p53 and Ki67 antibodies.
  • CONCLUSIONS: Histopathologists must recognize the potential for adenomatous/dysplastic foci in anorectal lesions to superficially resemble inflammatory cloacogenic polyps.
  • We believe that polypoid mucosal prolapse changes can be a secondary phenomenon, due to adenomas close to or at the anorectal junction.
  • [MeSH-major] Adenoma / pathology. Intestinal Mucosa / pathology. Intestinal Polyps / diagnosis. Rectal Neoplasms / pathology. Rectal Prolapse / pathology. Rectum / pathology

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  • (PMID = 18484980.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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13. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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14. Zhou PH, Yao LQ, Chen WF: [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum]. Zhonghua Wai Ke Za Zhi; 2008 Sep 15;46(18):1386-9
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  • [Title] [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum].
  • OBJECTIVE: To assess the clinical efficacy of endoscopic treatment for colorectal adenomatous polyps and early-stage carcinomas.
  • METHODS: Between January 2006 and October 2007, 245 patients with colorectal adenomatous polyps and early-stage carcinomas with lifting sign(+) were treated by such endoscopic techniques as polypectomy, endoscopic mucosal resection (EMR), endoscopic piecemeal mucosal resection (EPMR) and endoscopic submucosal dissection (ESD).
  • CONCLUSIONS: Endoscopic resection appears to be an efficacious procedure to treat adenomatous polyp and early-stage carcinoma and provide pathological information about the whole lesion.
  • [MeSH-major] Adenomatous Polyps / surgery. Colorectal Neoplasms / surgery. Endoscopes, Gastrointestinal

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  • (PMID = 19094508.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev; 2005;(3):CD003548
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  • [Title] Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps.
  • Experimental and epidemiological evidence has been suggestive but not conclusive for a protective role for high dietary calcium intake.
  • Intervention studies with colorectal cancer as an endpoint are difficult to perform owing to the large number of patients and the long follow-up required; studies using the appearance of colorectal adenomatous polyps as a surrogate endpoint are therefore considered in reviewing the existing evidence.
  • OBJECTIVES: This systematic review aims to assess the effect of supplementary dietary calcium on the incidence of colorectal cancer and the incidence or recurrence of adenomatous polyps.
  • SELECTION CRITERIA: Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in humans are reviewed.
  • Studies of healthy adults and studies of adults at higher risk of colon cancer due to family history, previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are excluded.
  • For the development of recurrent colorectal adenoma, a reduction was found (OR 0.74, CI 0.58,0.95) when the results from both trials were combined.
  • AUTHORS' CONCLUSIONS: Although the evidence from two RCTs suggests that calcium supplementation might contribute to a moderate degree to the prevention of colorectal adenomatous polyps, this does not constitute sufficient evidence to recommend the general use of calcium supplements to prevent colorectal cancer.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Calcium, Dietary / therapeutic use. Colorectal Neoplasms / prevention & control. Dietary Supplements
  • [MeSH-minor] Adenoma / complications. Humans. Randomized Controlled Trials as Topic


16. Park SY, Kim BC, Shin SJ, Lee SK, Kim TI, Kim WH: Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years. Hepatogastroenterology; 2009 May-Jun;56(91-92):677-81
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  • [Title] Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years.
  • BACKGROUND/AIMS: Several reports have suggested a trend of right-side shift of colorectal cancer; however, there were only a few studies on the chronologic changes in the distribution of adenomatous polyps.
  • We aimed to study the changes in the distribution of colorectal adenomatous polyps over the past ten years.
  • Patients who had an adenomatous polyp with a diameter of at least 5mm were included.
  • Of these, patients with a history of colon resection, colorectal cancer, colorectal polyp, inflammatory bowel disease, HNPCC, or familial adenomatous polyposis were excluded.
  • RESULTS: A total of 2,498 patients and 4,591 adenomatous polyps were included in this study.
  • Analysis with respect to number of patients showed significant increases in the proportion of patients with adenomatous polyp on the proximal colon, from 48.5% to 66.3% (p<0.001).
  • Analysis with respect to number of polyps revealed that the proportion of adenomatous polyps on the proximal colon significantly increased from 48.9% to 62.3% (p<0.001).
  • CONCLUSIONS: The proportion of adenomatous polyp on the proximal colon significantly increased over the past 10 years.
  • [MeSH-major] Adenomatous Polyposis Coli / ethnology. Adenomatous Polyposis Coli / pathology. Asian Continental Ancestry Group / statistics & numerical data

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  • (PMID = 19621679.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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17. Oset P, Jasińska A, Szcześniak P, Orszulak-Michalak D, Talar-Wojnarowska R, Małecka-Panas E: [Analysis of serum gastrin levels in patients with adenomatous polyps of the colon]. Pol Merkur Lekarski; 2009 May;26(155):458-61

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  • [Title] [Analysis of serum gastrin levels in patients with adenomatous polyps of the colon].
  • Adenomatous polyps are known risk factor of colon cancer.
  • Gastrin is a peptide hormone involved in the growth of both normal and malignant intestinal tissue, which probably may promote progression through the adenoma-carcinoma sequence.
  • MATERIAL AND METHODS: The study included 60 patients with adenomatous polyps of the colon and 30 healthy volunteers.
  • There was no association between gastrin levels and size, number, localisation and histologic type of polyps (p > 0.05).
  • CONCLUSION: Despite of elevated serum levels in patients with colonic adenomas we did not observe the association between gastrin levels and size, grade of dysplasia and histologic type of polyps.
  • [MeSH-major] Adenomatous Polyps / blood. Gastrins / blood

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  • (PMID = 19606697.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Gastrins
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18. Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels AB: Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology; 2008 Feb;134(2):388-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cigarette smoking and adenomatous polyps: a meta-analysis.
  • BACKGROUND & AIMS: Through the past 2 decades, a consistent association between cigarette smoking and colorectal adenomatous polyps, recognized precursor lesions of colorectal cancer, has been shown.
  • We performed a meta-analysis to provide a quantitative pooled risk estimate of the association, focusing on the different characteristics of the study populations, study designs, and clinical feature of the polyps.
  • CONCLUSIONS: This meta-analysis provides strong evidence of the detrimental effect of cigarette smoking on the development of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colorectal Neoplasms / epidemiology. Smoking / adverse effects


19. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev; 2008;(1):CD003548
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps.
  • Experimental and epidemiological evidence has been suggestive but not conclusive for a protective role for high dietary calcium intake.
  • Intervention studies with colorectal cancer as an endpoint are difficult to perform owing to the large number of patients and the long follow-up required; studies using the appearance of colorectal adenomatous polyps as a surrogate endpoint are therefore considered in reviewing the existing evidence.
  • OBJECTIVES: This systematic review aims to assess the effect of supplementary dietary calcium on the incidence of colorectal cancer and the incidence or recurrence of adenomatous polyps.
  • SELECTION CRITERIA: Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in humans are reviewed.
  • Studies of healthy adults and studies of adults at higher risk of colon cancer due to family history, previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are excluded.
  • For the development of recurrent colorectal adenoma, a reduction was found (OR 0.74, CI 0.58,0.95) when the results from both trials were combined.
  • AUTHORS' CONCLUSIONS: Although the evidence from two RCTs suggests that calcium supplementation might contribute to a moderate degree to the prevention of colorectal adenomatous polyps, this does not constitute sufficient evidence to recommend the general use of calcium supplements to prevent colorectal cancer.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Calcium, Dietary / therapeutic use. Colorectal Neoplasms / prevention & control. Dietary Supplements
  • [MeSH-minor] Adenoma / complications. Humans. Randomized Controlled Trials as Topic


20. Kim JH, Lee SY, Kim BK, Choe WH, Kwon SY, Sung IK, Park HS, Jin CJ: Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy. World J Gastroenterol; 2008 Mar 28;14(12):1903-7
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  • [Title] Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy.
  • AIM: To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy.
  • METHODS: Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision.
  • Both pre- and post-sprayed images were shown to 16 examiners, who were asked to interpret the lesions as either hyperplastic or adenomatous polyps.
  • Regression analysis demonstrated that surrounding colonic mucosa was the only factor that was significantly related to accuracy in discriminating adenomatous from hyperplastic polyps (P < 0.001).
  • Accuracy was higher for polyps with linear surrounding colonic mucosa than for those with nodular surrounding colonic mucosa (P < 0.001), but was not related to the shape, location, or size of the polyp.
  • CONCLUSION: The accuracy of predicting histology is significantly related to the pattern of colonic mucosa surrounding the polyp.
  • Making a histological diagnosis of colon polyps merely by acetic acid spray is helpful for colon polyps with linear, regularly patterned surrounding colonic mucosa, and less so for those with nodular, irregularly patterned surrounding colonic mucosa.
  • [MeSH-major] Acetic Acid. Adenomatous Polyps. Colonic Polyps. Endoscopy / methods. Hyperplasia. Intestinal Mucosa

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  • (PMID = 18350630.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] Q40Q9N063P / Acetic Acid
  • [Other-IDs] NLM/ PMC2700415
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21. Ramadas A Jr, Kandiah M, Zarida H, Yunus Gul AG, Faizal JA: Obesity and risk of colorectal adenomatous polyps: a case-control study in hospital kuala lumpur. Malays J Nutr; 2009 Mar;15(1):1-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obesity and risk of colorectal adenomatous polyps: a case-control study in hospital kuala lumpur.
  • Several studies have proposed that obesity is a risk factor for colorectal adenoma.
  • This case-control study examined the relationship between body mass index (BMI), waist circumference, waistto-hip ratio (WHR), body fat percentage and colorectal adenomatous polyps (CRA) in patients who have had a colonoscopy at the Hospital Kuala Lumpur (HKL).
  • The mean BMI of female case subjects was significantly higher than control females (25.63 + 4.87 kg/m2 vs. 23.86 + 3.70 kg/m2, p<0.05) but the difference in BMI was not significant in men.

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  • (PMID = 22691799.001).
  • [ISSN] 1394-035X
  • [Journal-full-title] Malaysian journal of nutrition
  • [ISO-abbreviation] Malays J Nutr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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22. Kim CS, Kim MC, Cheong HK, Jeong TH: [The association of obesity and left colonic adenomatous polyps in Korean adult men]. J Prev Med Public Health; 2005 Nov;38(4):415-9
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  • [Title] [The association of obesity and left colonic adenomatous polyps in Korean adult men].
  • OBJECTIVES: We wanted to evaluate the relationship between obesity and left colonic adenomatous polyps in Korean adult men.
  • RESULTS: There were 99 cases of colonic adenomatous polyps.
  • The BMI and WHR were associated with the adenomatous polyps (odds ratio, 1.81 [95% CI=1.02-3.19] for a BMI > or = 25.0 as compared with a BMI < or = 22.9, odds ratio, 3.94 [95% CI = 1.77-8.77] for a WHR > or = 0.95 as compared with a WHR < or = 0.86).
  • The BMI was not associated with the risk of adenomatous polyps after additional adjustment was made for the WHR, but the association between the WHR and adenomatous polyps was still positive and independent of the BMI (odds ratio, 4.15 [95% CI=1.63-10.59]).
  • CONCLUSIONS: The results support that obesity, and particularly abdominal obesity, can be associated with an increased risk of incurring colonic adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / etiology. Colonic Polyps / etiology. Obesity / complications

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  • (PMID = 16358826.001).
  • [ISSN] 1975-8375
  • [Journal-full-title] Journal of preventive medicine and public health = Yebang Ŭihakhoe chi
  • [ISO-abbreviation] J Prev Med Public Health
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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23. Kim BJ, Kim YH, Sinn DH, Kang KJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC: Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males. Cancer Causes Control; 2010 Jun;21(6):939-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males.
  • RESULTS: Subjects in their 50 s had significantly more adenomatous polyps than subjects in their 40 s (32.7% vs. 26.0%, p < 0.05).
  • The incidence of adenomatous polyp increased with increasing quartiles of HbA1C as follows: first quartile (19.9%, HbA1c 4.0-5.0), second quartile (27.8%, HbA1c 5.1-5.3), third quartile (32.7%, HbA1c 5.4-5.5), and fourth quartile (34.9%, HbA1c = 5.6-8.8)(p = 0.008).
  • When combining quartile of HbA1c and age (40 s vs. 50 s) according to HbA1C levels, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c <5.4% was significantly lower than that in subjects in their 50 s.
  • However, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c > or =5.4% was similar to that in subjects in their 50 s with average risk for CRC.
  • CONCLUSIONS: An elevated HbA1c may be useful as a clinical predictor of adenomatous polyps in male subjects <50 years of age who have average risk for CRC.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology

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  • (PMID = 20373014.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hemoglobin A, Glycosylated
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24. Kurland JE, Beck SE, Solomon CJ, Brann OS, Carethers JM, Huang SC: Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A. J Pediatr Gastroenterol Nutr; 2007 Mar;44(3):318-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A.
  • OBJECTIVES: Cyclooxygenase-2 (COX-2) expression is increased in colorectal cancers and has been reported to be upregulated in Peutz-Jeghers polyps.
  • To determine whether germline and somatic loss of BMPR1A in polyps from a patient with juvenile polyposis syndrome have altered COX-2 expression, we characterized a patient with juvenile polyposis syndrome for BMPR1A germline mutations and examined the polyps for BMPR1A expression and COX-2 expression.
  • Multiple polypectomies were performed, and several polyps showed adenomatous change.
  • Genomic DNA was extracted from polyp material for loss of heterozygosity (LOH) analyses with microsatellite markers.
  • In polyp domains containing cystic and adenomatous epithelium, no LOH was observed using markers near the BMPR1A locus.
  • Immunostaining indicated decreased expression of phospho-SMAD1 (pSMAD1), functionally downstream of the mutant BMPR1A receptor in the cystic epithelium, with further reduction in adenomatous portions within the polyp.
  • COX-2 protein, normally not expressed in the colon, was present and increased in polyp epithelium.
  • CONCLUSIONS: Decreased expression of pSMAD1 in the cystic epithelium with further reduction in the adenomatous area, and increase in COX-2 expression within polyps from the BMPR1A heterozygote, suggest a potential mechanism for adenomatous pathogenesis in these hamartomatous polyps.

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  • (PMID = 17325551.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090231-05; United States / NIDDK NIH HHS / DK / T32 DK007202-32; United States / NCI NIH HHS / CA / R01 CA090231-05; United States / NCI NIH HHS / CA / R01 CA090231; United States / NCI NIH HHS / CA / R01-CA90231; United States / NIDDK NIH HHS / DK / K08-DK64560A; United States / NIDDK NIH HHS / DK / T32 DK007202; United States / NIDDK NIH HHS / DK / DK007202-32
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Smad1 Protein; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.30 / BMPR1A protein, human; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I
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25. Kim H, Kim HJ, Chi SG, Lee SK, Joo GR, Dong SH, Kim BH, Chang YW, Lee JI, Chang R: Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea. World J Gastroenterol; 2006 Feb 14;12(6):951-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea.
  • AIM: Recently, germ-line mutation in the base excision repair gene MYH has been identified to cause a novel autosomal recessive form of familial adenomatous polyposis (FAP).
  • In this study, we screened 30 patients with multiple adenomatous polyps for MYH mutations to assess its prevalence and ethnic specificity in Korea.
  • METHODS: Thirty patients (21 men and 9 women; mean age 62.3 years) with multiple adenomatous polyps were examined for MYH mutations.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Mutation

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  • [Cites] Cancer Res. 2003 Nov 15;63(22):7595-9 [14633673.001]
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  • (PMID = 16521226.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC4066163
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26. Glazer E, Golla V, Forman R, Zhu H, Levi G, Bodenheimer HC Jr: Serrated adenoma is a risk factor for subsequent adenomatous polyps. Dig Dis Sci; 2008 Aug;53(8):2204-7
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serrated adenoma is a risk factor for subsequent adenomatous polyps.
  • BACKGROUND: Serrated adenomas (SA) are histologically defined by the presence of both hyperplastic and adenomatous features.
  • These uncommon polyps are thought to play an important role in the development of sporadic colorectal cancers (CRC) with microsatellite instability (MSI).
  • There is paucity of data on the risk of progression of SA to CRC.
  • This study was undertaken to define the relationship between SA and the future development of adenomatous polyps.
  • METHODS: Colonoscopic biopsies that contained a pathologic diagnosis of SA were identified from a pathology database of a major urban academic medical center.
  • These were matched to controls by age, sex, indication for colonoscopy, polyp type and number and duration of follow-up.
  • Of these, 80 patients (0.5%) with SA were found, and of these SA, 80% were found in the left colon.
  • The average age of patients undergoing colonoscopy was 58.5 years, and the average age of patients with SA was 68 years (P = 0.004).
  • Of all patients with SA, 7 (9%) had concomitant CRC.
  • On follow-up examination four patients (24%) and no controls had adenomatous polyps (P = 0.01).
  • CONCLUSIONS: While SA are uncommon, they are commonly associated with colorectal cancer.
  • This study found a significant association between SA and the subsequent development of adenomatous polyps.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Aged. Case-Control Studies. Colonoscopy. Disease Progression. Female. Humans. Hyperplasia. Male. Middle Aged. Retrospective Studies. Risk Factors

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  • (PMID = 18320324.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Erdem L, Akbayir N, Yildirim S, Köksal HM, Yenice N, Gültekin OS, Sakiz D, Peker O: Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon. Turk J Gastroenterol; 2005 Dec;16(4):207-11
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon.
  • The necessity of colonoscopy in patients with an adenoma of<or=5 mm found on sigmoidoscopy is controversial.
  • METHODS: Patients found to have rectosigmoid adenomatous polyps on colonoscopy were included in the study.
  • These adenomas were grouped as diminutive (<or=5 mm), small (6-10 mm) or large (>or=11 mm) polyps.
  • These groups were compared regarding the presence of proximal adenoma and advanced proximal neoplasia (>10 mm adenoma and/or villous histology and/or high grade dysplasia or cancer).
  • Polyps found in the rectum and sigmoid colon were considered as distal polyps and polyps other than these were considered as proximal polyps.
  • RESULTS: In this study, of 1124 consecutive patients who underwent colonoscopy between April 1997 and January 2002, 184 (16%) had 258 adenomatous polyps in the rectosigmoid area.
  • The polyps were diminutive (<or=5 mm) in 105, small (6-10 mm) in 46 and large (>or=11 mm) in 33 patients.
  • Forty-one of the patients (39%) with diminutive polyps, 20 of the patients (43%) with small polyps and 19 of the patients (57%) with large polyps had neoplasm in the proximal bowel.
  • The rate of advanced proximal neoplasm was found to be significantly higher in the group with large polyps in the rectosigmoid area than in the groups with small and diminutive polyps (p<0.05).
  • In 104 patients (57%) with polyp(s) in rectum and sigmoid colon, no associated polyp or cancer was encountered in the proximal colon.
  • CONCLUSION: Colonoscopy is indicated when adenomatous polyp, regardless of size, is found on rectosigmoidoscopy performed because of symptoms.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neoplasms, Multiple Primary. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 16547849.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Turkey
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28. Gibson CJ, Parry NM, Jakowski RM, Cooper J: Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog. Vet Pathol; 2010 Jan;47(1):116-9
MedlinePlus Health Information. consumer health - Esophageal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog.
  • Endoscopically, the distal aspect of the esophagus was inflamed with a polypoid mass that protruded into the esophageal lumen.
  • This article reports a case of spontaneous esophageal adenomatous polyp with intestinal metaplasia (Barrett esophagus) and reviews the pathogenesis of esophageal metaplasia and adenocarcinoma.
  • [MeSH-major] Adenomatous Polyps / veterinary. Barrett Esophagus / veterinary. Dog Diseases / pathology. Esophageal Neoplasms / veterinary. Intestines / pathology

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  • (PMID = 20080491.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Kim BJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC, Choe YH, Choi YH, Shim SG, Kim YH: Coexistence between carotid artery stenosis and colorectal adenomatous polyps in middle-aged men. Digestion; 2010;81(1):20-6
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence between carotid artery stenosis and colorectal adenomatous polyps in middle-aged men.
  • BACKGROUND: Colorectal neoplasia and cardiovascular disease appear to share common risk factors.
  • RESULTS: The prevalence of overall colorectal adenomatous polyps (APs) was 31.4% (591/1,877).
  • [MeSH-major] Adenomatous Polyps / complications. Carotid Stenosis / complications. Colorectal Neoplasms / complications

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] Digestion. 2010;81(1):18-9 [20029205.001]
  • [CommentIn] Digestion. 2010;81(1):16-7 [20029204.001]
  • (PMID = 20051688.001).
  • [ISSN] 1421-9867
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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30. Guo X, Zhang L, Wu M, Wang N, Liu Y, Er L, Wang S, Gao Y, Yu W, Xue H, Xu Z, Wang S: Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma. Mol Biol Rep; 2010 Jan;37(1):219-25
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.
  • The aim of this study is to investigate the correlation of the DNMT3B G39179T polymorphism with the susceptibilities of colorectal adenomatous polyps and adenocarcinoma.
  • This case-control study included 146 colorectal adenomatous polyps, 170 colorectal adenocarcinoma patients, and 157 normal controls.
  • Family history of colorectal cancer significantly increases the risk of developing colorectal adenomatous polyps and adenocarcinoma.
  • Compared with DNMT3B T/T genotype, the G allelotype (G/T + G/G genotype) had lower risk to develop colorectal adenocarcinoma (OR = 0.50, 95% CI = 0.29-0.87); while there was no significant difference between the colorectal adenomatous polyps patients and controls (OR = 0.63, 95% CI = 0.37-1.09), although descending tendency could be found in this polyps group.
  • Meanwhile, combined G/T + G/G genotypes were found to have a lower risk in non-drinkers to develop both colorectal adenomatous polyps and adenocarcinoma (OR = 0.54, 95% CI = 0.31-0.96 and OR = 0.48, 95% CI = 0.27-0.84, respectively).
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyps / genetics. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / genetics. DNA (Cytosine-5-)-Methyltransferase / genetics. Genetic Predisposition to Disease. Polymorphism, Single Nucleotide / genetics

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  • (PMID = 19626461.001).
  • [ISSN] 1573-4978
  • [Journal-full-title] Molecular biology reports
  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA methyltransferase 3B
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31. Jung WT, Li MS, Goel A, Boland CR: JC virus T-antigen expression in sporadic adenomatous polyps of the colon. Cancer; 2008 Mar 1;112(5):1028-36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] JC virus T-antigen expression in sporadic adenomatous polyps of the colon.
  • The hypothesis that JCV DNA sequences and T-antigen (T-Ag) expression may be present in adenomatous polyps of the colon was tested.
  • METHODS: DNA was extracted from 74 paraffin-embedded adenomatous polyps.
  • RESULTS: JCV T-Ag sequences were found in 82% (61 of 74) of adenomas, and T-Ag protein was expressed in 16% (12 of 74) of these polyps.
  • The T-Ag staining was localized exclusively in the nuclei of adenoma cells, but never in the cytoplasm or the adjacent nonneoplastic cells.
  • The prevalence of MSI-H and non-MSI-H (MSI-L/MSS) in adenomatous polyps was 9.5% (7 of 74) and 90.5% (67 of 74), respectively.
  • Among the 61 adenomas that harbored JCV sequences, 8% (5 of 61) were MSI-H, and similarly among 12 adenomatous polyps expressing T-Ag protein 8% (1 of 12) of the adenomatous polyps were MSI-H.
  • CONCLUSIONS: JCV T-Ag DNA sequences are frequently present in adenomatous polyps of the colon, and T-Ag is expressed specifically in the nuclei of these premalignant lesions.

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  • (PMID = 18205186.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA098572-05; United States / NCI NIH HHS / CA / R01 CA098572; United States / NCI NIH HHS / CA / R01 CA 98572; United States / NCI NIH HHS / CA / R01 CA098572-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
  • [Other-IDs] NLM/ NIHMS187525; NLM/ PMC2855201
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32. Hwang ST, Cho YK, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Won KH, Jin W: Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. J Gastroenterol Hepatol; 2010 Mar;25(3):562-7
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps.
  • Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver.
  • This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.
  • We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361).
  • RESULTS: The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group.
  • By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60).
  • An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps.
  • CONCLUSION: NAFLD was associated with colorectal adenomatous polyps.
  • Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / complications. Fatty Liver / complications

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  • Genetic Alliance. consumer health - Non-alcoholic steatohepatitis (NASH).
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  • (PMID = 20074156.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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33. Steinhagen E, Markowitz AJ, Guillem JG: How to manage a patient with multiple adenomatous polyps. Surg Oncol Clin N Am; 2010 Oct;19(4):711-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How to manage a patient with multiple adenomatous polyps.
  • Adenomatous polyps are found on screening colonoscopy in 22.5% to 58.2% of the adult population and therefore represent a common problem.
  • Patients with multiple adenomatous polyps are of unique interest because a proportion of these patients have an inheritable form of colorectal cancer.
  • [MeSH-major] Adenomatous Polyposis Coli / therapy. Colorectal Neoplasms, Hereditary Nonpolyposis / therapy
  • [MeSH-minor] Adenomatous Polyps / genetics. Adenomatous Polyps / pathology. Adenomatous Polyps / therapy. Genetic Predisposition to Disease. Humans

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20883948.001).
  • [ISSN] 1558-5042
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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34. Mizuno S, Morita Y, Inui T, Asakawa A, Ueno N, Ando T, Kato H, Uchida M, Yoshikawa T, Inui A: Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy. Int J Cancer; 2005 Dec 20;117(6):1058-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy.
  • A significant increase in the incidence of adenomatous polyps (p < 0.0001) and decrease in normal colonoscopic findings (p < 0.0005) were observed in seropositive patients than those seronegative.
  • [MeSH-major] Adenomatous Polyps / microbiology. Colonic Neoplasms / microbiology. Colonic Polyps / microbiology. Colonoscopy. Helicobacter Infections. Helicobacter pylori

  • MedlinePlus Health Information. consumer health - Colonic Polyps.
  • MedlinePlus Health Information. consumer health - Colonoscopy.
  • MedlinePlus Health Information. consumer health - Helicobacter Pylori Infections.
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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • [CommentIn] Int J Cancer. 2006 Oct 15;119(8):1999-2000 [16708392.001]
  • (PMID = 15986436.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Immunoglobulin G
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35. Benes Z, Antos Z: Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy. Anticancer Res; 2009 Nov;29(11):4737-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy.
  • BACKGROUND: It has been established that the removal of adenomatous colon polyps drastically reduces the incidence of colorectal cancer (CRC), but polypectomy is not without risk.
  • The aim was to determine the correlation between the results of an optical biopsy system and the histopathology report of the physical biopsy specimens of the same polyps removed at colonoscopy.
  • PATIENTS AND METHODS: Paired optical and physical biopsies were performed on 55 polyps with complete polypectomy of the same tissue.
  • RESULTS: Fifty-three adenomatous polyps and two hyperplastic polyps were identified by the hospital pathologist.
  • The optical biopsy system identified 52 polyps as suspect (adenomatous) and 2 as non-suspect (hyperplastic).
  • One villous adenoma could not be optically analyzed due to friability.
  • CONCLUSION: The WavSTAT Optical Biopsy System provides accurate information to the gastroenterologist to assist in distinguishing between hyperplastic and adenomatous polyps.
  • It is safe for the patient and does not unduly increase the time required for an endoscopic examination.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colon / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy / methods. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonoscopy / methods. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Middle Aged. Optics and Photonics / methods. Prospective Studies

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  • (PMID = 20032428.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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36. Ji BT, Weissfeld JL, Chow WH, Huang WY, Schoen RE, Hayes RB: Tobacco smoking and colorectal hyperplastic and adenomatous polyps. Cancer Epidemiol Biomarkers Prev; 2006 May;15(5):897-901
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  • [Title] Tobacco smoking and colorectal hyperplastic and adenomatous polyps.
  • Colorectal adenomas and possibly some hyperplastic polyps are precursors of colorectal cancer.
  • Tobacco use is associated in epidemiologic studies with these polyps, although links between smoking and colorectal cancer are less consistent.
  • To characterize the role of tobacco in early colorectal carcinogenesis, we compared tobacco use among 4,383 subjects with histologically verified benign (hyperplastic or adenomatous) polyps of the distal colon (descending colon, sigmoid, and rectum) with tobacco use among 33,667 subjects who were endoscopy negative for distal colon tumors, in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Trial, a randomized trial of flexible sigmoidoscopy.
  • Risks, estimated by the odds ratio (OR), associated with current cigarette use were OR = 4.4 [95% confidence interval (95% CI), 3.7-5.2] for hyperplastic polyps only, OR = 1.8 (95% CI, 1.5-2.1) for adenomas only, and OR = 6.2 (95% CI, 4.7-8.3) for subjects with both hyperplastic and adenomatous polyps concurrently.
  • Effects were weaker among ex smokers; the smoking-associated ORs remained consistently higher for hyperplastic polyps.
  • Tobacco-associated risks for multiple polyps were also stronger when hyperplastic disease was involved.
  • In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions.
  • [MeSH-major] Adenomatous Polyposis Coli / etiology. Colorectal Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 16702367.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
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37. Smith GV, Feakins R, Farthing MJ, Ballinger A: Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. Am J Clin Pathol; 2005 Mar;123(3):415-20
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  • [Title] Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps.
  • Gastric adenomatous polyps are rare findings in upper gastrointestinal endoscopy; however, they are associated strongly with malignant transformation.
  • In the present study, we immunohisto-chemically assessed the expression of cyclooxygenase (COX)-2, beta-catenin, p53, and adenomatous polyposis coli (APC) in paraffin-embedded specimens of 14 gastric adenomas.
  • Similar alterations in oncoprotein expression were seen in gastric cancers but not in normal control sections.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Adenomatous Polyps / metabolism. Cytoskeletal Proteins / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism. Stomach Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15716238.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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38. Ghelase F, Mogoş DS, Mărgăritescu D, Iordache S, Ghelase MS, Râmboiu S, Mogoş G, Bică M, Săftoiu A, Georgescu I: [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications]. Chirurgia (Bucur); 2009 Mar-Apr;104(2):159-65
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  • [Title] [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications].
  • AIM: To detect the patients with colorectal adenomatous polyps or those with adenocarcinoma areas with a view to prevent and to treat the malignant disease.
  • MATERIAL AND METHOD: A prospective study including 309 patients hospitalized between 2000-2005 diagnosed with isolated adenomatous polyps after repeated colonoscopies.
  • The research method was selective screening with identification of risk factors regarding the evolution of colorectal polyps in early cancer, using colonoscopy and histopathological examination.
  • RESULTS: We identified 464 single or multiple isolated polyps of which 399 were adenomas, 59 hyperplastic polyps and 6 other types of lesions.
  • Histologically we recorded 41 (13.27%) polyps with a low grade of dysplasia, 56 (18.12%) with severe dysplasia and 30 (9.7%) intramucosal adenocarcinoma with submucosal invasion.
  • TREATMENT: Colonoscopic polypectomy was used for benign polyps and in situ carcinoma.
  • CONCLUSIONS: High grade of dysplasia, the number of polyps, ulceration, bleeding, intraepithelial areas of neoplastic transformation are predictive factors for early colorectal cancer.
  • Depth of submucosal invasion of malignant transformed polyps are important pathological factors to predict lymphatic metastasis and to select the therapeutic procedure.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Colectomy / methods. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Cell Transformation, Neoplastic / pathology. Colonic Polyps / diagnosis. Colonic Polyps / surgery. Female. Humans. Male. Prospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 19499658.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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39. Byun TJ, Han DS, Ahn SB, Cho HS, Eun CS, Jeon YC, Sohn JH, Oh YH: Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer. Gut Liver; 2009 Jun;3(2):130-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer.
  • Pseudoinvasion or pseudocarcinomatous invasion in an adenomatous polyp of the colon can be unfamiliar to an endoscopist.
  • Pseudoinvasion in an adenomatous polyp represents prolapse of the adenomatous epithelium into its stalk.
  • In most cases its morphology does not differ from of general adenomatous polyps, but in some cases it can morphologically mimic a malignant polyp with submucosal invasion due to mass-like lesioning of its stalk.
  • This makes it difficult for endoscopists to differentiate pseudoinvasion in an adenoma from an invasive carcinoma by conventional endoscopy; instead, endoscopic ultrasonography can provide useful information for differentiating these conditions.
  • We report on an 82-year-old man who presented with a large pedunculated polyp with a thick stalk in the sigmoid colon, which mimicked a submucosal invasive carcinoma.
  • The patient was diagnosed with pseudoinvasion in an adenomatous polyp after segmental resection of the sigmoid colon.

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  • (PMID = 20431736.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852693
  • [Keywords] NOTNLM ; Adenomatous polyps / EUS / Malignant polyp / Pseudoinvasion
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40. Dixon A, Wurm P, Hart A, Robinson R: Distal adenomatous polyps are rare in patients with inflammatory bowel disease. Postgrad Med J; 2006 Jan;82(963):76-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distal adenomatous polyps are rare in patients with inflammatory bowel disease.
  • OBJECTIVE: There is an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD).
  • RESULTS: Of 106 patients (61 male, 45 female, mean age of 59 years), 80 suffered from ulcerative colitis, 20 from Crohn's disease, and six from indeterminate colitis.
  • CONCLUSIONS: The results suggest that distal adenomatous polyps are rare in patients aged 55-64 years with IBD compared with a control population.
  • This supports the hypothesis that lesions other than polyps are important for the development of colorectal cancer in patients with IBD.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / etiology. Inflammatory Bowel Diseases / etiology

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  • (PMID = 16397087.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 4Q81I59GXC / Mesalamine; MRK240IY2L / Azathioprine
  • [Other-IDs] NLM/ PMC2563726
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41. Parker-Ray N, Barakat J, Roy PK, White RE, Schrader RM, Hoffman RM: Statin use does not prevent recurrent adenomatous polyp formation in a VA population. Indian J Gastroenterol; 2010 Jun;29(3):106-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Statin use does not prevent recurrent adenomatous polyp formation in a VA population.
  • PURPOSE: To evaluate whether statin use was associated with recurrent adenomatous polyps.
  • During follow-up, 88 (47%) of patients received statins, but use was not protective against recurrent adenomas (hazard ratio = 1.36, 95% CI 0.35-8.27).
  • Only number of polyps at initial colonoscopy predicted recurrent adenomas (1.98, 95% CI 1.27-3.08).
  • CONCLUSIONS: The use of statins was not protective against the recurrence of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. Neoplasm Recurrence, Local / prevention & control. Veterans

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  • (PMID = 20658327.001).
  • [ISSN] 0975-0711
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors
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42. Rastogi A, Pondugula K, Bansal A, Wani S, Keighley J, Sugar J, Callahan P, Sharma P: Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology. Gastrointest Endosc; 2009 Mar;69(3 Pt 2):716-22
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  • [Title] Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology.
  • BACKGROUND: The 2 main types of colon polyps are adenomas and hyperplastic.
  • Pit patterns on the surface of polyps have been described by using magnification chromoendoscopy, which can help differentiate between polyp types.
  • Narrow band imaging (NBI) is a novel technology that enhances the visualization of surface mucosal and vascular patterns on the polyp surface.
  • Earlier we described, in a pilot study, patterns seen on the polyp surface with NBI that can help differentiate between adenomas and hyperplastic polyps with a high degree of accuracy.
  • OBJECTIVE: The aim of this study was to evaluate the interobserver and intraobserver agreement (among endoscopists) for the NBI surface mucosal and vascular patterns and prediction of polyp histology and the accuracy of the investigators to predict polyp histology based on these patterns.
  • METHODS: NBI images of the polyp surface mucosal and vascular patterns obtained in our pilot trial were retrieved.
  • A teaching set of 20 images was selected to educate and demonstrate the polyp patterns to 4 endoscopists.
  • Subsequently, the test set of images was evaluated by the 4 endoscopists for quality, polyp pattern, and prediction of polyp type.
  • Interobserver agreement (k value) was calculated among the 4 assessors for the polyp patterns and predicted histology.
  • By using the final histology as the criterion standard, the accuracy of polyp-type prediction was calculated for each assessor.
  • After a period of 2 months, all polyp images were reevaluated by the assessors (as before), and all findings were recorded in a similar fashion.
  • These results were used for calculation of intraobserver agreement (k value) and the accuracy of the assessors in predicting polyp type.
  • RESULTS: Photographs of 65 polyps were included in the test set and were evaluated by the 4 assessors.
  • Thirty-eight polyps were adenomatous, and 27 were hyperplastic.
  • The kappa value for the interobserver agreement for polyp surface pattern was 0.57 (moderate) and for prediction of polyp type was 0.63 (substantial).
  • The kappa value for the intraobserver agreement of the 4 assessors for the surface patterns was 0.70, 0.65, 0.60, and 0.79, and for the prediction of polyp type was 0.87, 0.71, 0.61, 0.81.
  • The accuracy to predict polyp type ranged from 80% to 86% for the 4 assessors in the first reading and from 85% to 91% in the second reading, with every assessor showing an improvement in accuracy in the second reading.
  • LIMITATIONS: A single-center study, with a limited number of polyps.
  • CONCLUSIONS: This initial evaluation showed that the NBI polyp patterns described in our pilot study are reproducible, easy to learn, reasonably accurate, and have the potential for use in daily clinical practice for the real-time differentiation of colon polyps.
  • [MeSH-major] Colonic Polyps / pathology. Colonoscopy / statistics & numerical data

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  • [CommentIn] Gastrointest Endosc. 2009 Mar;69(3 Pt 2):723-5 [19251017.001]
  • (PMID = 19251016.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Schoen RE, Weissfeld JL, Kuller LH, Thaete FL, Evans RW, Hayes RB, Rosen CJ: Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology; 2005 Aug;129(2):464-75
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  • [Title] Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps.
  • We evaluated the relationship of insulin, IGF-I, insulin-like growth factor binding protein (IGFBP) 3, and visceral adipose tissue (VAT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer.
  • RESULTS: Four hundred fifty-eight subjects were enrolled, of which 202 subjects had an adenoma, 70 of which were an advanced adenoma.
  • In an unadjusted logistic regression analysis using sex-specific quartile cut points, subjects in quartile 4 in comparison with quartile 1 of IGF-I (odds ratio [OR] = 1.7; [95% CI: 1.0-2.9], Ptrend = .03), IGF-I/IGFBP-3 ratio (OR = 1.9 [95% CI: 1.1-3.3], Ptrend = .01), and insulin (OR = 2.1 [95% CI: 1.2-3.6], Ptrend = .04) were at increased risk of adenoma.
  • Visceral adipose tissue was not associated with adenoma risk.
  • These data support the hypothesis that insulin and IGF-I may contribute to the development and advancement of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology. Insulin / blood. Insulin-Like Growth Factor Binding Protein 1 / blood. Insulin-Like Growth Factor Binding Protein 3 / blood. Neoplasm Invasiveness / pathology

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  • (PMID = 16083703.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K07-CA72561
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin; 0 / Insulin-Like Growth Factor Binding Protein 1; 0 / Insulin-Like Growth Factor Binding Protein 3
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44. Niv Y, Vilkin A, Levi Z: Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study. J Clin Gastroenterol; 2010 Aug;44(7):489-94
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  • [Title] Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study.
  • We compared JCV antibody titers in patients with simple adenoma, advanced adenomatous polyp (AAP), CRC, and healthy controls, and evaluated JCV DNA in the tissue.
  • Normal colonoscopy, simple adenoma, AAP, and CRC were found in 41, 19, 12, and 25 cases, respectively.
  • The average titer for normal controls, simple polyp, AAP, and CRC was 2.61+/-0.72, 2.95+/-0.77, 3.33+/-0.76, and 3.30+/-0.50 log, respectively (P<0.001).
  • Viral DNA could not be shown in the serum.
  • The presence of neoplastic tissue T-Ag (in 33.3% of the patients) was not associated with a difference in the log titer of serum antibody.
  • If confirmed, our finding may serve as a marker for CRC or for an earlier stage of AAP.
  • [MeSH-major] Adenoma / virology. Adenomatous Polyps / virology. Colorectal Neoplasms / virology. JC Virus / immunology

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  • [CommentIn] J Clin Gastroenterol. 2010 Aug;44(7):466-8 [20520564.001]
  • (PMID = 20421810.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
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45. Bafandeh Y, Daghestani D, Esmaili H, Aharizad S: Distribution of cancer and adenomatous polyps in the colorectum: study in an Iranian population. Asian Pac J Cancer Prev; 2006 Jan-Mar;7(1):65-8
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  • [Title] Distribution of cancer and adenomatous polyps in the colorectum: study in an Iranian population.
  • OBJECTIVE: There is consensus that the majority of colorectal carcinomas (CRCs) arise from adenomatous polyps.
  • If the same etiologic factors are operating for polyps and cancers their anatomical distributions should be the same.
  • MATERIALS AND METHODS: We reviewed, retrospectively , endoscopically reported anatomic sites of all adenomatous polyps and CRCs which were histologically confirmed from Jan 1992 to Dec 2005 in Tabriz, the North-west of Iran.
  • One hundred and forty-three CRC's and 180 adenomatous polyps (in 145 patients) were found.
  • Age and sex of patients, size and anatomic sites of polyps and cancers were studied.
  • In both cancer and adenoma cases the most common presenting symptoms were rectal bleeding and bloody diarrhea ( 52.4% , 16.9% and 39.2% , 15.8% for cancers and adenomas, respectively) without any significant difference(0>05).
  • The propensity for polyps to be found in the descending colon was of borderline significance (p=0.07).
  • The cecal segment uniquely demonstrated cancers(p=0.01) without any polyps.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / epidemiology. Adenomatous Polyposis Coli / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology

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  • (PMID = 16629518.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
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46. Levin B, Lieberman DA, McFarland B, Andrews KS, Brooks D, Bond J, Dash C, Giardiello FM, Glick S, Johnson D, Johnson CD, Levin TR, Pickhardt PJ, Rex DK, Smith RA, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory Group, US Multi-Society Task Force, American College of Radiology Colon Cancer Committee: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology; 2008 May;134(5):1570-95
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  • [Title] Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
  • CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized.
  • In 2006 to 2007, the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults.
  • In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy.
  • When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that primarily is effective at early cancer detection and a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Colorectal Neoplasms / diagnosis. Mass Screening / standards. Population Surveillance / methods. Practice Guidelines as Topic. Societies, Medical


47. Arber N, Kuwada S, Leshno M, Sjodahl R, Hultcrantz R, Rex D, Exisulind Study Group: Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study. Gut; 2006 Mar;55(3):367-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study.
  • At baseline colonoscopy, left sided polyps (3-10 mm) were tattooed, measured, and left in place.
  • Follow up sigmoidoscopy was performed after six months, and removal of any remaining polyps at the 12 month colonoscopy.
  • The primary efficacy variable was change in polyp size from baseline.
  • The decrease in median polyp size was significantly greater (p=0.03) in patients who received exisulind 400 mg (-10 mm2) compared with those who received placebo (-4 mm2).
  • Complete or partial response was significantly higher in the exisulind 400 mg group (54.6%) compared with the placebo group (30.2%), and disease progression was significantly lower (6.1% v 27.9%) (p=0.04 and 0.02, respectively).
  • CONCLUSION: Exisulind caused significant regression of sporadic adenomatous polyps but was associated with more toxicity.
  • This model of polyp regression, short in its term and involving a comparatively small patient sample size, may be the best available tool to assess a therapeutic regimen before launching into large preventive clinical studies.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Antineoplastic Agents / therapeutic use. Sulindac / analogs & derivatives
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonoscopy. Combined Modality Therapy. Disease Progression. Dose-Response Relationship, Drug. Double-Blind Method. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16150858.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 184SNS8VUH / Sulindac; K619IIG2R9 / sulindac sulfone
  • [Other-IDs] NLM/ PMC1856089
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48. Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, Dash C, Giardiello FM, Glick S, Levin TR, Pickhardt P, Rex DK, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory Group, US Multi-Society Task Force, American College of Radiology Colon Cancer Committee: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin; 2008 May-Jun;58(3):130-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
  • CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized.
  • In 2006 to 2007, the American Cancer Society, the US Multi Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults.
  • In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy.
  • When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps and a screening test that primarily is effective at early cancer detection.
  • [MeSH-major] Colonic Polyps / prevention & control. Colorectal Neoplasms / prevention & control. Mass Screening / standards


49. Castillo-Alcala F, Mans C, Bos AS, Taylor WM, Smith DA: Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo). Can Vet J; 2010 Nov;51(11):1261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo).
  • The histopathological diagnosis of the resected mass was an adenomatous polyp of the colon.
  • [MeSH-major] Adenomatous Polyps / veterinary. Colonic Polyps / veterinary. Ferrets

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  • [Cites] J Am Anim Hosp Assoc. 1997 Mar-Apr;33(2):156-60 [9111726.001]
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  • (PMID = 21286327.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal = La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2957035
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50. Tony J, Harish K, Ramachandran TM, Sunilkumar K, Thomas V: Profile of colonic polyps in a southern Indian population. Indian J Gastroenterol; 2007 May-Jun;26(3):127-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Profile of colonic polyps in a southern Indian population.
  • BACKGROUND: In Western countries, colonic polyps are usually adenomatous in nature, are evenly distributed along the entire colon in asymptomatic per-sons and show a left-sided predominance in symptomatic patients.
  • Clinical features, colonoscopic description and histologic findings of all patients with polyps were noted.
  • Association of the degree of dysplasia with the size, site and type of polyps and the person's age was assessed.
  • RESULTS: Polyps were seen in 124 (5.1%) of 2412 complete colonoscopies.
  • Mean age of patients with polyps was 58.1 (SD 19.9) years; ninety were men.
  • A majority of polyps (92%) were located in the left colon.
  • They were adenomatous in 99 (79.8%), juvenile in 12 (9.8%), hyperplastic in 11 (8.8 %), inflammatory in 1 (0.8%) and Peutz-Jegher's polyp in 1 (0.8%).
  • Dysplasia was severe in large (>2 cm) polyps compared to small (< 1 cm) ones (p< 0.001).
  • Age of patient and location of polyp had no association with degree of dysplasia.
  • CONCLUSIONS: In southern Indian adults, most colonic polyps are adenomatous and are in the left colon.
  • Large polyps are associated with severe dysplasia.
  • [MeSH-major] Colonic Polyps / epidemiology

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  • (PMID = 17704579.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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51. Siddiqui AA, Maddur H, Naik S, Cryer B: The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitus. Dig Dis Sci; 2008 Apr;53(4):1042-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitus.
  • The aim of our study was to determine whether poor control of diabetes mellitus (DM) is associated with increased prevalence of colonic adenomatous polyps (APs), especially those that are advanced .
  • Significant variables by UA were included in a stepwise logistic regression analysis to determine independent predictors of aggressive clinical behavior by the polyps.
  • All values are presented as means +/- SE, and statistical significance was determined at P < or = 0.05.
  • Logistic regression, as measured by HbA1c, demonstrated that poorly controlled DM-2 independently predicted a greater prevalence of right-sided AP, a more advanced lesion at the time of presentation, a greater number of polyps, and greater use of exogenous insulin.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology. Colonic Neoplasms / blood. Colonic Neoplasms / pathology. Diabetes Mellitus, Type 2 / blood. Hemoglobin A, Glycosylated / metabolism

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  • (PMID = 17939046.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Hemoglobin A, Glycosylated; 0 / hemoglobin A1c protein, human
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52. Mai PL, Korde L, Kramer J, Peters J, Mueller CM, Pfeiffer S, Stratakis CA, Pinto PA, Bratslavsky G, Merino M, Choyke P, Linehan WM, Greene MH: A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. J Med Case Rep; 2007 Mar 28;1:9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report.
  • BACKGROUND: Germ-cell testicular cancer has not been definitively linked to any known hereditary cancer susceptibility disorder.
  • His evaluation as part of an etiologic study of familial testicular cancer revealed multiple colon polyps (adenomatous, hyperplastic, and hamartomatous) first found in his 50 s, multiple lipomas, multiple hyperpigmented skin lesions, left kidney cancer diagnosed at age 64, and a growth-hormone producing pituitary adenoma with associated acromegaly diagnosed at age 64.
  • DISCUSSION: The constellation of benign and malignant neoplasms in the context of this patient's familial testicular cancer raised the possibility that these might be manifestations of a known hereditary susceptibility cancer syndrome; however, genetic testing for the three syndromes that were most likely to explain these findings did not show any mutation.

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  • (PMID = 17411461.001).
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CP / N02CP11019
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1847830
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53. Fiducia G, Gandolfo L, Bosco V: [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases]. Chir Ital; 2008 Mar-Apr;60(2):227-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases].
  • [Transliterated title] Polipi adenomatosi rettoanali protrudenti isolati asportati per via transanale. Nostra esperienza.
  • Sixteen patients with low rectal or anal canal neoplastic polyps underwent transanal resection.
  • [MeSH-major] Intestinal Polyps / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18689170.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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54. Stelzner F: [Autoregulatory growth control of adenomatous polyps and carcinogenesis in the colorectal region. Basics of tumor surgery Part I]. Chirurg; 2006 Nov;77(11):1048-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Autoregulatory growth control of adenomatous polyps and carcinogenesis in the colorectal region. Basics of tumor surgery Part I].
  • Autoregulatory growth control of adenomatous polyps in the colon and rectum is an important factor in the success of sphincter-sparing surgical resections.
  • Similar to normal mucosa, adenomatous polyps in the colorectum show autoregulatory growth control in their tissues.
  • However, convincing evidence on a molecular level that this so-called adenoma-carcinoma sequence indeed occurs in vivo is lacking.
  • [MeSH-major] Adenomatous Polyps / pathology. Cell Division / physiology. Colonic Polyps / pathology. Colonic Polyps / surgery. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Homeostasis / physiology
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Bone Marrow Cells / pathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Chromosome Aberrations. Colon / pathology. Colon / surgery. Gene Expression Regulation, Neoplastic / physiology. Humans. Neoplasm Staging. Prognosis. Rectum / pathology. Rectum / surgery

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  • [CommentIn] Chirurg. 2006 Nov;77(11):1061-2 [17066270.001]
  • (PMID = 17068665.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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55. Sato Y, Nozaki R, Yamada K, Takano M, Haruma K: Relation between obesity and adenomatous polyps of the large bowel. Dig Endosc; 2009 Jul;21(3):154-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relation between obesity and adenomatous polyps of the large bowel.
  • BACKGROUND: We compared the prevalence of colorectal adenoma (polyps) in men and women and examined the role of body mass index (BMI) on polyp risk according to patient age and gender.
  • METHODS: The risk of developing colorectal polyps was studied in 15 380 subjects (7155 men and 8225 women) who underwent colonoscopy for the first time from April 1998 to March 2006 at our 'Human Dry Dock', which is the check-up service provided in Japan.
  • Eligible subjects were 20-86 years old (mean age +/- SD, 47.3 +/- 8.5) and were free of invasive cancer, hyperplastic polyps and familial polyposis.
  • Polyps were found in 1590 subjects (1062 men and 528 women).
  • The odds ratio (OR) of detection of polyps in relation to obesity was determined in all cases by multivariate logistic regression analysis after making an adjustment for gender and age.
  • RESULTS: The OR of polyp detection in obese subjects (BMI >or= 25) versus non-obese subjects (BMI < 25, OR = 1) was 1.34 (P < 0.001) in men and 1.13 (P = 0.26) in women.
  • CONCLUSIONS: We conclude that obesity in men is a risk factor for the development of polyps.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology

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  • (PMID = 19691761.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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56. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA: Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol; 2007 Jan-Mar;44(1):14-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies.
  • BACKGROUND: Gastric polyps are small gastric lesions, asymptomatic in most cases and are generally discovered inadvertently during upper digestive endoscopy.
  • AIM: To retrospectively review the characteristics and frequency of gastric polyps, derived from the gastric mucosal epithelium in a large series of endoscopies.
  • All patients had at least one gastric polyp, as confirmed by histological examination.
  • RESULTS: The polyps were classified as hyperplastic, adenomatous and fundic gland polyps.
  • The most of them measure less than 1 cm (hyperplastic polyps - 60,5%; adenomatous polyps - 73,6%; fundic gland polyps - 72%).
  • Hyperplastic polyps were the most frequent and accounted for 71.3% of the cases, whereas fundic gland polyps accounted for 16.3% and adenomatous polyps for 12.4%.
  • Hyperplastic and adenomatous polyps were primarily single, whereas fundic gland polyps tended to be multiple.
  • A carcinoma was detected in one hyperplastic polyp (0.9%) and in two adenomatous polyps (10.5%).
  • High grade dysplastic foci were found in four adenomatous polyps (21%).
  • CONCLUSIONS: The digestive endoscopy is the safest and efficient method for the diagnosis of the gastric polyps, that in most of the patients does not show characteristic symptoms.
  • The histopathological definition is not possible to the endoscopic glance being needed the pathologist's aid, once the conduct to be adopted will depend on the result of the biopsy.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Adult. Aged. Aged, 80 and over. Female. Gastric Fundus. Gastroscopy. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 17639176.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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57. Cardoso J, Molenaar L, de Menezes RX, van Leerdam M, Rosenberg C, Möslein G, Sampson J, Morreau H, Boer JM, Fodde R: Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cancer Res; 2006 Mar 1;66(5):2514-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosomal instability in MYH- and APC-mutant adenomatous polyps.
  • Recently, biallelic germ line mutations in the MYH gene were found to be responsible for MYH-associated polyposis (MAP), an autosomal recessive predisposition to multiple colorectal polyps, often indistinguishable from the dominant familial adenomatous polyposis (FAP) syndrome caused by inherited APC mutations.
  • Here, we analyzed MYH- and APC-mutant polyps by combining laser capture microdissection, isothermal genomic DNA amplification, and array comparative genomic hybridization.
  • Up to 80% and 60% of the MAP and FAP polyps showed aneuploid changes, respectively.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Aneuploidy. Chromosomal Instability. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Genes, APC. Germ-Line Mutation

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  • (PMID = 16510566.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0301154
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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58. McLean MH, Murray GI, Fyfe N, Hold GL, Mowat NA, El-Omar EM: COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. Histopathology; 2008 Jun;52(7):806-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics.
  • AIMS: To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation.
  • The number of adenoma specimens was then extended to include polyps exhibiting an increasing degree of epithelial dysplasia.
  • Forty colonic hyperplastic polyps were also identified from the pathology diagnostic database and included in the analysis.
  • There was a statistically significant increase in COX-2 expression in colonic polyps compared with paired adjacent normal mucosa, chi(2) = 40.1, P = 0.001.
  • The probability of COX-2 expression increased along with increasing adenoma size and increasing degree of epithelial dysplasia.
  • Fifty-five per cent of the hyperplastic polyp specimens expressed COX-2.
  • CONCLUSIONS: This study associates COX-2 epithelial expression with a number of adenoma characteristics that convey an increased risk of malignant transformation.
  • [MeSH-major] Adenomatous Polyps / enzymology. Colonic Polyps / enzymology. Colorectal Neoplasms / enzymology. Cyclooxygenase 2 / metabolism. Intestinal Mucosa / enzymology

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  • (PMID = 18462368.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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59. Su YH, Wang M, Brenner DE, Norton PA, Block TM: Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. Ann N Y Acad Sci; 2008 Aug;1137:197-206
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  • [Title] Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.

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  • (PMID = 18837947.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA125642-01A2; United States / NCI NIH HHS / CA / CA86400; United States / NCI NIH HHS / CA / R01 CA125642; United States / NCI NIH HHS / CA / U01 CA086400; United States / NCI NIH HHS / CA / CA125642-01A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 9007-49-2 / DNA; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ NIHMS72455; NLM/ PMC2587049
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60. Tsai IC, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM: Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer; 2007 Mar 1;120(5):1005-12
Xenbase. Xenbase .

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  • [Title] Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
  • We speculated that mutations in the autoinhibitory domain of CKIdelta/epsilon might upregulate CKIdelta/epsilon activity and hence Wnt signaling and increase the risk of adenomatous polyps and colon cancer.
  • Exons encoding the CKIepsilon and CKIdelta regulatory domains were sequenced from DNA obtained from individuals with adenomatous polyps and a family history of colon cancer unaffected by familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer (HNPCC).
  • A CKIdelta missense mutation, changing a highly conserved residue, Arg324, to His (R324H), was found in an individual with large and multiple polyps diagnosed at a relatively young age.
  • Although the R324H mutation does not significantly change CKIdelta kinase activity in an in vitro kinase assay or Wnt/beta-catenin signal transduction as assessed by a beta-catenin reporter assay, it alters morphogenetic movements via a beta-catenin-independent mechanism in early Xenopus development.
  • This novel human CKIdelta mutation may alter the physiological role and enhance the transforming ability of CKIdelta through a Wnt/beta-catenin independent mechanism and thereby influence colonic adenoma development.
  • [MeSH-major] Adenomatous Polyps / genetics. Casein Kinase Idelta / genetics. Colonic Neoplasms / genetics

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 17131344.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / PC / N01-PC-3541; United States / NCI NIH HHS / CA / P01 CA73992; United States / NCI NIH HHS / CA / P30 CA42014; United States / NCI NIH HHS / CA / R01 CA40641; United States / NCI NIH HHS / CA / R01 CA80809
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin; 4QD397987E / Histidine; 94ZLA3W45F / Arginine; EC 2.7.11.1 / Casein Kinase Idelta
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61. Ayoub J, Granado B, Mhanna Y, Romain O: SVM based colon polyps classifier in a wireless active stereo endoscope. Conf Proc IEEE Eng Med Biol Soc; 2010;2010:5585-8
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • [Title] SVM based colon polyps classifier in a wireless active stereo endoscope.
  • This work focuses on the recognition of three-dimensional colon polyps captured by an active stereo vision sensor.
  • The study is related to Cyclope, this prototype sensor allows real time 3D object reconstruction and continues to be optimized technically to improve its classification task by differentiation between hyperplastic and adenomatous polyps.
  • Inspired by intensity histogram, the work shows a new approach that extracts a set of features based on depth histogram and combines stereo measurement with SVM classifiers to correctly classify benign and malignant polyps.
  • [MeSH-major] Algorithms. Colonic Polyps / classification. Endoscopes. Wireless Technology / instrumentation

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  • (PMID = 21096484.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Bresalier RS: Early detection of and screening for colorectal neoplasia. Gut Liver; 2009 Jun;3(2):69-80

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  • The long natural history of colorectal neoplasia affords the opportunity to use preventive measures to improve survival in this disease.
  • Currently screening for adenomatous polyps and early-stage cancers is the best methodology for improving survival.

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  • (PMID = 20431727.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852697
  • [Keywords] NOTNLM ; Adenoma / Colon cancer screening / Colonoscopy / Computed tomographic colonography / Fecal occult blood testing
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63. Kondi-Pafiti A, Frangou-Plemmenou M, Bakalianou C, Tsantopoulos M, Papadias K, Liapis A: Lesions of the subepithelial stromal zone of the lower female genital tract. An immunopathological study. Clin Exp Obstet Gynecol; 2009;36(4):226-9
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

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  • The stroma often fibroepithelial and ten adenomatous cervical polyps, 12 fibro-epithelial vaginal polyps, 20 non neoplastic cervices, 15 cone specimens with CIN changes and five specimens with infiltrative squamous cell carcinoma was investigated.
  • A subepithelial stromal layer was detected in 17/20 normal specimens, 16/20 cervical polyps, 10/12 vaginal polyps and in 6/15 cone biopsies but not in neoplastic specimens.
  • Vimentin staining was positive in all fibroepithelial polyps, normal specimens and in 6/10 adenomatous polyps.
  • In conclusion, loose mesenchymal stroma in the lower female genital tract of a fibrohistiocytic nature was observed with minimal smooth muscle participation--which is the matrix of vaginal and cervical polyps.
  • [MeSH-major] Adenomatous Polyps / pathology. Carcinoma, Squamous Cell / pathology. Conization. Uterine Cervical Neoplasms / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 20101853.001).
  • [ISSN] 0390-6663
  • [Journal-full-title] Clinical and experimental obstetrics & gynecology
  • [ISO-abbreviation] Clin Exp Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Vimentin
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64. Sampson JR, Jones N: MUTYH-associated polyposis. Best Pract Res Clin Gastroenterol; 2009;23(2):209-18
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  • MUTYH-associated polyposis (MAP) is an autosomal recessive disorder characterised by adenomatous polyps of the colorectum and a very high risk of colorectal cancer.
  • It appears to be at least as prevalent as autosomal dominant familial adenomatous polyposis (that is caused by truncating mutations in the APC gene) with which it shares important gastroenterological features.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Gene Expression Regulation, Neoplastic. Genetic Testing
  • [MeSH-minor] Adult. Aged. DNA Mutational Analysis. Early Detection of Cancer. Genetic Predisposition to Disease. Humans. Middle Aged. Patient Selection. Pedigree. Phenotype. Predictive Value of Tests. Risk Assessment. Young Adult

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  • (PMID = 19414147.001).
  • [ISSN] 1532-1916
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Number-of-references] 63
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65. Nam JH, Yang CH: [Clinical characteristics and risk factors of colon polyps in gyeongju and pohang area]. Korean J Gastroenterol; 2008 Sep;52(3):142-9
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  • [Title] [Clinical characteristics and risk factors of colon polyps in gyeongju and pohang area].
  • BACKGROUND/AIMS: The purposes of this study were to investigate various environmental factors for colon polyps and to analyze locoregional clinical characteristics of colon polyps in Gyeongju and Pohang area.
  • METHODS: From October 2005 to September 2006, patients who underwent colonoscopy were analyzed based on their ages, genders, body mass indices (BMI), dietary habits, smoking behaviors, accompaying diseases, and medications as risk factors for the occurrence of colon polyps.
  • Then clinical manifestations, gross appearances and pathologic findings of polyps were investigated.
  • RESULTS: Among 253 patients enrolled, a total of 296 colon polyps were found in 108 patients.
  • The incidence of colon polyps in more than 50-year old patients was 3.2-fold greater compared to less than 50-year old patients.
  • Smoking habits were also significantly associated with the occurence of colon polyps.
  • Among adenomatous polyps, tubulovillous type and moderate to severe dysplasia were frequently observed as the size increased, yet the location of polyps was not significantly associated.
  • CONCLUSIONS: Older age and smoking habit increase the risk of colon polyps.
  • Rectal polyps have less chance to be adenomatous type.
  • The larger the polyp grows, the more likely it to be tubulovillous and dysplastic.
  • [MeSH-major] Colonic Polyps / diagnosis. Colorectal Neoplasms / diagnosis
  • [MeSH-minor] Adenomatous Polyps / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Korea. Male. Middle Aged. Multivariate Analysis. Odds Ratio. Risk Factors. Rural Population. Surveys and Questionnaires

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  • (PMID = 19077510.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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66. Shrubsole MJ, Wu H, Ness RM, Shyr Y, Smalley WE, Zheng W: Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps. Am J Epidemiol; 2008 May 1;167(9):1050-8
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  • [Title] Alcohol drinking, cigarette smoking, and risk of colorectal adenomatous and hyperplastic polyps.
  • The authors evaluated alcohol drinking and cigarette smoking in relation to risk of colorectal polyps in a Nashville, Tennessee, colonoscopy-based case-control study.
  • In 2003-2005, cases with adenomatous polyps only (n = 639), hyperplastic polyps only (n = 294), and both types of polyps (n = 235) were compared with 1,773 polyp-free controls.
  • Consumption of at least five alcoholic drinks per week was not strongly associated with development of polyps.
  • Odds ratios for all polyp types were increased for dose, duration, and pack-years of cigarette smoking and were stronger for hyperplastic polyps than for adenoma.
  • Compared with never smoking, dose-response relations were particularly strong for current smoking and duration; for > or =35 years of smoking, odds ratios were 1.9 (95% confidence interval (CI): 1.4, 2.5) for adenomatous polyps only, 5.0 (95% CI: 3.3, 7.3) for hyperplastic polyps only, and 6.9 (95% CI: 4.4, 11.1) for both types of polyps.
  • Compared with current smoking, time since cessation was associated with substantially reduced odds; for > or =20 years since quitting, odds ratios were 0.4 (95% CI: 0.3, 0.6) for adenoma only, 0.2 (95% CI: 0.1, 0.3) for hyperplastic polyps only, and 0.2 (95% CI: 0.2, 0.4) for both polyp types.
  • These findings support the adverse role of cigarette smoking in colorectal tumorigenesis and suggest that quitting smoking may substantially reduce the risk of colorectal polyps.

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  • (PMID = 18304959.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / P50CA950103; United States / NCI NIH HHS / CA / R01CA97386
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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67. Lee YH, Ji JD, Song GG: Adjusted indirect comparison of celecoxib versus rofecoxib on cardiovascular risk. Rheumatol Int; 2007 Mar;27(5):477-82
Hazardous Substances Data Bank. CELECOXIB .

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  • We performed adjusted indirect comparison of celecoxib versus rofecoxib for cardiovascular events using two data on The Adenomatous Polyp Prevention on Vioxx (APPROVe) trial and Adenoma Prevention with Celecoxib (APC) trial.
  • The RRs for cardiovascular events derived from the adjusted indirect comparisons of the two coxibs did not significantly differ from unity (celecoxib versus rofecoxib; RR 0.95, 95% CI 0.76-1.19, p = 0.67).
  • [MeSH-minor] Adenoma / prevention & control. Adenomatous Polyps / prevention & control. Angina, Unstable / chemically induced. Celecoxib. Humans. Middle Aged. Risk. Thromboembolism / chemically induced

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  • (PMID = 17051359.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors; 0 / Lactones; 0 / Pyrazoles; 0 / Sulfonamides; 0 / Sulfones; 0QTW8Z7MCR / rofecoxib; JCX84Q7J1L / Celecoxib
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68. Berger BM, Schroy PC 3rd, Rosenberg JL, Lai-Goldman M, Eisenberg M, Brown T, Rochelle RB, Billings PR: Colorectal cancer screening using stool DNA analysis in clinical practice: early clinical experience with respect to patient acceptance and colonoscopic follow-up of abnormal tests. Clin Colorectal Cancer; 2006 Jan;5(5):338-43
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  • An abnormal stool DNA test correlated with a colonoscopically demonstrable abnormality in 49% of cases (34 of 69).
  • Abnormal findings, including CRC in 3 patients (4%; 1 with Dukes A and 2 with Dukes B disease), single or multiple adenomatous polyps in 23 patients (33%), hyperplastic polyps in 3 patients (4%), and colitis in 5 patients (7%).
  • CONCLUSION: Stool DNA testing provides an acceptable noninvasive alternative for CRC screening that can identify early-stage CRCs and adenomatous polyps in routine clinical practice.


69. Mathew J, Saklani AK, Borghol M: Surveillance colonoscopy in patients with colorectal cancer: how often should we be doing it? Surgeon; 2006 Feb;4(1):3-5, 62
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  • BACKGROUND: The optimum protocol for colonoscopic surveillance following curative resection for colorectal cancer has not been established.
  • The variables studied included the tumour site, Duke's stage, number of recurrences, number of metachronous tumours, size and number of polyps and their biopsy results.
  • Adenomatous polyps were identified in 24 patients of which nine had multiple/advanced adenomas (equal to or more than 1cm adenomatous polyps, or with severe dysplasia).
  • [MeSH-major] Adenoma / surgery. Colonoscopy / statistics & numerical data. Colorectal Neoplasms / surgery. Neoplasm Recurrence, Local / diagnosis

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  • [CommentIn] Surgeon. 2007 Apr;5(2):125 [17455380.001]
  • (PMID = 16459492.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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70. Rao CV, Yang YM, Swamy MV, Liu T, Fang Y, Mahmood R, Jhanwar-Uniyal M, Dai W: Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci U S A; 2005 Mar 22;102(12):4365-70
SciCrunch. OMIM: Data: Gene Annotation .

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  • The adenomatous polyposis coli (Apc) gene also plays an important role in regulating genomic stability, as mutations of Apc cause aneuploidy.
  • Here we show that whereas Apc(Min)(/+) mice developed many adenomatous polyps, mostly in the small intestine, by 3 mo of age; BubR1(+/-)Apc(Min)(/+) compound mutant mice developed 10 times more colonic tumors than Apc(Min)(/+) mice.

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  • (PMID = 15767571.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA110057; United States / NCI NIH HHS / CA / CA90658; United States / NCI NIH HHS / CA / R01 CA080003; United States / NCI NIH HHS / CA / R03 CA110057; United States / NCI NIH HHS / CA / CA80003; United States / NCI NIH HHS / CA / R01 CA090658
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bub1b protein, mouse; 0 / Cell Cycle Proteins; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ PMC555497
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71. Hao CY, Moore DH, Wong P, Bennington JL, Lee NM, Chen LC: Alteration of gene expression in macroscopically normal colonic mucosa from individuals with a family history of sporadic colon cancer. Clin Cancer Res; 2005 Feb 15;11(4):1400-7
The Lens. Cited by Patents in .

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  • To determine whether these alterations also occur in the MNCM of individuals who have not developed colon cancer but are at high risk of doing so, we measured gene expression in the MNCM of individuals with a family history of colon cancer.
  • CONCLUSIONS: Molecular abnormalities that precede the appearance of adenomatous polyp are present in the MNCM of individuals who have a family history of colon cancer.
  • To assess this possibility, prospective studies will be needed to determine whether or not altered gene expression is associated with the subsequent development of adenomatous polyps and/ or colonic carcinomas.

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  • (PMID = 15746039.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-8; 0 / Membrane Proteins; 0 / PPAR delta; 0 / PPAR gamma; 0 / Serum Amyloid A Protein; 63231-63-0 / RNA; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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72. Bouraoui S, Azouz H, Kechrid H, Lemaiem F, Mzabi-Regaya S: [Peutz-Jeghers' syndrome with malignant development in a hamartomatous polyp: report of one case and review of the literature]. Gastroenterol Clin Biol; 2008 Mar;32(3):250-4
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • [Title] [Peutz-Jeghers' syndrome with malignant development in a hamartomatous polyp: report of one case and review of the literature].
  • [Transliterated title] Dégénérescence inaugurale d'un polype hamartomateux au cours du syndrome de Peutz-Jeghers: à propos d'un cas avec revue de la littérature.
  • The malignant potential of hamartomatous polyps in Peutz-Jeghers' (PPJ) syndrome has been debated.
  • Although it is a very rare event, these polyps can become malignant, as demonstrated by this report.
  • The patient had colonic carcinoma which developed in a hamartomatous polyp.
  • The malignant development of this colonic hamartomatous polyp arising in Peutz-Jeghers' syndrome was pathologically confirmed at surgery.
  • This case also shows a sequence of hamartoma-dysplasia-carcinoma in a hamartomatous polyp without adenomatous changes.
  • This suggests that hamartomatous polyps in Peutz-Jeghers' syndrome may develop into adenocarcinoma and may be a precursor of gastrointestinal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Cell Transformation, Neoplastic / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Hamartoma / pathology. Peutz-Jeghers Syndrome / complications

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  • (PMID = 18456106.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 32
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73. Kim MS, Jung HK, Jung HS, Choi JY, Na YJ, Pyun GW, Ryu JH, Moon IH, Jo MS: [A Case of Cronkhite-Canada syndrome showing resolution with Helicobacter pylori eradication and omeprazole]. Korean J Gastroenterol; 2006 Jan;47(1):59-64
Hazardous Substances Data Bank. OMEPRAZOLE .

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  • Histology of polyps from the stomach showed features of juvenile or retention type (hamartomatous) polyps with Helicobacter pylori (H. pylori) infection.
  • The large pedunculated colonic polyps showed hamartomatous polyps with adenomatous component and polypectomy was performed.
  • After the treatment with H. pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed.
  • [MeSH-major] Anti-Ulcer Agents / therapeutic use. Helicobacter Infections / drug therapy. Helicobacter pylori. Omeprazole / therapeutic use. Polyps / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Colonic Polyps / complications. Colonic Polyps / microbiology. Colonic Polyps / pathology. Female. Humans. Hyperpigmentation / pathology. Middle Aged. Nails, Malformed / pathology. Proton Pump Inhibitors. Syndrome

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  • (PMID = 16434870.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Proton Pump Inhibitors; KG60484QX9 / Omeprazole
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74. Yee J, Rosen MP, Blake MA, Baker ME, Cash BD, Fidler JL, Grant TH, Greene FL, Jones B, Katz DS, Lalani T, Miller FH, Small WC, Sudakoff GS, Warshauer DM: ACR Appropriateness Criteria on colorectal cancer screening. J Am Coll Radiol; 2010 Sep;7(9):670-8
International Agency for Research on Cancer - Screening Group. diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers .

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  • This malignancy is ideally suited for screening because the detection and removal of the precursor adenomatous polyp can prevent most colorectal cancers from ever forming.
  • The double-contrast barium enema is an alternative imaging test that is appropriate particularly when CTC is not available.
  • Imaging tests including CTC and the double-contrast barium enema are usually not indicated for colorectal cancer screening in high-risk patients with polyposis syndromes or inflammatory bowel disease.
  • [MeSH-minor] Adenoma / complications. Biopsy. Colitis, Ulcerative / radiography. Colonography, Computed Tomographic / methods. Colonoscopy / statistics & numerical data. Crohn Disease / radiography. Humans. Risk Assessment. Survival Rate. Tomography, X-Ray Computed / methods. United States / epidemiology

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  • [Copyright] Copyright (c) 2010 American College of Radiology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20816627.001).
  • [ISSN] 1558-349X
  • [Journal-full-title] Journal of the American College of Radiology : JACR
  • [ISO-abbreviation] J Am Coll Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Hassan C, Pickhardt PJ, Rex DK: A resect and discard strategy would improve cost-effectiveness of colorectal cancer screening. Clin Gastroenterol Hepatol; 2010 Oct;8(10):865-9, 869.e1-3
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND & AIMS: A "resect and discard" policy has been proposed for diminutive polyps detected by screening colonoscopy, because hyperplastic and adenomatous polyps can be distinguished, in vivo, by using narrow-band imaging (NBI).
  • In a resect and discard approach, diminutive lesions (≤5 mm), classified by endoscopy with high confidence, were not analyzed by a pathologist.
  • RESULTS: With universal referral of resected polyps to pathology, colonoscopy screening costs an estimated $3222/person, with a gain of 51 days/person.
  • Adoption of a resect and discard policy for eligible diminutive polyps resulted in a savings of $25/person, without any meaningful effect on screening efficacy.
  • In the sensitivity analysis, the rate of high-confidence diagnosis and the accuracy for endoscopic polyp determination were the most meaningful variables.
  • CONCLUSIONS: In a simulation model, a resect and discard strategy for diminutive polyps detected by screening colonoscopy resulted in a substantial economic benefit without an impact on efficacy.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonoscopy / economics. Colonoscopy / methods. Colorectal Neoplasms / diagnosis. Early Detection of Cancer / economics. Early Detection of Cancer / methods

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20621680.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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76. Varughese S, Kumar AR, George A, Castro FJ: Morning-only one-gallon polyethylene glycol improves bowel cleansing for afternoon colonoscopies: a randomized endoscopist-blinded prospective study. Am J Gastroenterol; 2010 Nov;105(11):2368-74
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

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  • OBJECTIVES: Inadequate bowel preparation is a known factor associated with increased failure rates of afternoon colonoscopy and lower adenoma detection rates.
  • There was no difference in the study groups on overall polyp detection rate, adenomatous polyps, or number of patients with adenomas.

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  • [CommentIn] Evid Based Med. 2011 Jun;16(3):87-8 [21386116.001]
  • (PMID = 20606677.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cathartics; 30IQX730WE / Polyethylene Glycols
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77. Ramos C, De Jesús-Caraballo J, Toro DH, Ojeda A, Martínez-Souss J, Dueño MI, Cruz-Correa M: Is barium enema an adequate diagnostic test for the evaluation of patients with positive fecal occult blood? Bol Asoc Med P R; 2009 Apr-Jun;101(2):23-8
Hazardous Substances Data Bank. Barium sulfate .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Secondary objectives were to determine: the diagnostic accuracy according to adenoma location, size, and pathologic characteristics; and patient satisfaction with each procedure METHODS: Cross-sectional study comparing the ac curacy of DCBE and colonoscopy in detecting adenomatous polyps and/or colorectal cancer in patients with positive FOBT.
  • Polyps identified during colonoscopy were removed and classified by histology.
  • Polyps were fou in 40/50 (80%) patients in colonoscopy, compared to 19/50 (38%) in DCBE.
  • Eighty-four percent of polyps were missed by DCBE.
  • Diagnostic accuracy of DCBE was inferior to colonoscopy, for all size polyps and larg adenomas.
  • [MeSH-major] Adenocarcinoma / radiography. Adenomatous Polyps / radiography. Barium Sulfate. Colonic Polyps / radiography. Colorectal Neoplasms / radiography. Contrast Media. Enema. Gastrointestinal Hemorrhage / radiography. Occult Blood

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  • (PMID = 19954097.001).
  • [ISSN] 0004-4849
  • [Journal-full-title] Boletín de la Asociación Médica de Puerto Rico
  • [ISO-abbreviation] Bol Asoc Med P R
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Puerto Rico
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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78. Tanaka T: Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog; 2009;8:5

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  • The large majority of colorectal malignancies develop from an adenomatous polyp (adenoma).
  • Carcinomas usually originate from pre-existing adenomas, but this does not imply that all polyps undergo malignant changes and does not exclude de novo oncogenesis.
  • Besides adenomas, there are other types of pre-neoplasia, which include hyperplastic polyps, serrated adenomas, flat adenomas and dysplasia that occurs in the inflamed colon in associated with inflammatory bowel disease.

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  • (PMID = 19332896.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2678864
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79. Sano Y, Ikematsu H, Fu KI, Emura F, Katagiri A, Horimatsu T, Kaneko K, Soetikno R, Yoshida S: Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps. Gastrointest Endosc; 2009 Feb;69(2):278-83
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  • [Title] Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps.
  • BACKGROUND: Although microvascular vessels on the surface of colorectal polyps are observed by narrow-band imaging (NBI) with magnification, its clinical usefulness is still uncertain.
  • DESIGN: Prospective polyp study.
  • Patients with polyps >10 mm and those with polyps previously evaluated by histologic examination or colonoscopy were excluded.
  • INTERVENTION: Lesions were classified into 2 groups: polyps with invisible or faintly visible MC vessels as nonneoplastic and polyps with clearly visible MC vessels as neoplastic.
  • RESULTS: Of 92 eligible patients enrolled in this study, 150 lesions, including 39 (26%) hyperplastic polyps and 111 (74%) adenomatous polyps, were detected.
  • Observation of MC vessels detected 107 of 111 neoplastic polyps and 36 of 39 nonneoplastic polyps.
  • CONCLUSION: Observation of surface MC vessels by magnifying NBI is a useful and simple method for differentiating colorectal nonneoplastic and neoplastic polyps.
  • [MeSH-major] Capillaries / pathology. Colonic Polyps / pathology. Colonoscopy / methods

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  • (PMID = 18951131.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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80. Gurzu S, Jung I, Prantner I, Ember I, Pávai Z, Mezei T: The expression of cytoskeleton regulatory protein Mena in colorectal lesions. Rom J Morphol Embryol; 2008;49(3):345-9
The Lens. Cited by Patents in .

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  • In our study, we tried to observe the immunohistochemical expression of mammalian Ena (Mena) in the colorectal polyps and carcinomas.
  • We analyzed 10 adenomatous polyps (five with dysplasia) and 36 adenocarcinomas.
  • We observed that Mena was not expressed in the normal colorectal mucosa neither in polyps without dysplasia, but its expression was very high in polyps with high dysplasia.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Polyps / metabolism. Polyps / pathology

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  • (PMID = 18758639.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Enah protein, human; 0 / Microfilament Proteins
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81. Groen EJ, Roos A, Muntinghe FL, Enting RH, de Vries J, Kleibeuker JH, Witjes MJ, Links TP, van Beek AP: Extra-intestinal manifestations of familial adenomatous polyposis. Ann Surg Oncol; 2008 Sep;15(9):2439-50
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  • [Title] Extra-intestinal manifestations of familial adenomatous polyposis.
  • Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene.
  • FAP is characterized by the formation of hundreds to thousands of colorectal adenomatous polyps.
  • This means, it is comparable to other diseases such as the MEN syndromes, Von Hippel-Lindau disease and neurofibromatosis.
  • Therefore, a specialized multidisciplinary approach to optimize health care-common for other disorders-is not usually taken for FAP patients.
  • FAP-related complications, for which medical attention is essential, are not rare and their estimated lifetime risk presumably exceeds 30%.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / genetics. Germ-Line Mutation. Humans

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  • (PMID = 18612695.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
  • [Number-of-references] 111
  • [Other-IDs] NLM/ PMC2518080
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82. Fraser CG, Mathew CM, Mowat NA, Wilson JA, Carey FA, Steele RJ: Evaluation of a card collection-based faecal immunochemical test in screening for colorectal cancer using a two-tier reflex approach. Gut; 2007 Oct;56(10):1415-8
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  • 558 individuals participated, 320 refused and 246 did not return samples.
  • In the 302 FIT-negative individuals, 2 (0.7%) had cancer and 12 (4.0%) had large or multiple (high-risk) adenomatous polyps.
  • In contrast, of 254 positive individuals, 47 (18.5%) had cancer and 54 (21.3%) had high-risk polyps.
  • Sensitivity, specificity, and positive and negative likelihood ratios (and 95% CIs) for cancer were 95.9% (84.8 to 99.3), 59.2% (54.7 to 63.5), 2.35 (2.08 to 2.65) and 0.07 (0.02 to 0.27), and for cancer and high-risk polyps were 87.8% (80.1 to 92.9), 65.3% (60.6 to 69.7), 2.53 (2.19 to 2.93) and 0.19 (0.11 to 0.31), respectively.
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Aged. Colonoscopy. Female. Humans. Male. Middle Aged. Patient Participation. Sensitivity and Specificity

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  • [CommentIn] Gut. 2007 Oct;56(10):1343-4 [17872566.001]
  • (PMID = 17309886.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2000260
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83. Johnson JC, Schmidt CR, Shrubsole MJ, Billheimer DD, Joshi PR, Morrow JD, Heslin MJ, Washington MK, Ness RM, Zheng W, Schwartz DA, Coffey RJ, Beauchamp RD, Merchant NB: Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol; 2006 Nov;4(11):1358-65
The Lens. Cited by Patents in .

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  • The purpose of this pre-validation study was to determine if urinary PGE-M levels can be used as a biomarker to discriminate between healthy patients and those with colorectal disease.
  • METHODS: Urine PGE-M was assessed in a total of 228 patients with CRC, colonic adenomatous polyps, Crohn's disease, and in subjects with no endoscopically detectable disease.
  • Urine PGE-M levels among patients with Crohn's disease (median, 19.85 [IQR, 6.89-90.2]), CRC (median, 14.65 [IQR, 5.94-92.1]), or large adenomas greater than 1 cm in size (median, 18.85 [IQR, 11.9-25.6]) were significantly increased when compared with patients who had either small polyps less than 1 cm in size (median, 9.69 [IQR, 6.41-22.2]), or no polyps (median, 7.05 [IQR, 2.35-24.7]) (P = .0001).

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  • (PMID = 16996805.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA46413; United States / NIDDK NIH HHS / DK / DK48831; United States / NIDDK NIH HHS / DK / T32 DK007673; United States / NIDDK NIH HHS / DK / DK52334; United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA046413; United States / NCI NIH HHS / CA / T32 CA106183; United States / NIGMS NIH HHS / GM / GM15431; United States / NIDDK NIH HHS / DK / DK07673; United States / NIDDK NIH HHS / DK / R01 DK048831; United States / NCI NIH HHS / CA / P01 CA077839; United States / NCI NIH HHS / CA / CA106183; United States / NIGMS NIH HHS / GM / P50 GM015431; United States / NCRR NIH HHS / RR / RR00095; United States / NCI NIH HHS / CA / P30 CA068485; United States / NCI NIH HHS / CA / R01 CA069457; United States / NCRR NIH HHS / RR / M01 RR000095; United States / NCI NIH HHS / CA / CA95103; United States / NIDDK NIH HHS / DK / R01 DK052334; United States / NCI NIH HHS / CA / CA68485; United States / NCI NIH HHS / CA / CA77839; United States / NCI NIH HHS / CA / CA69457
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Prostaglandins; 73303-30-7 / 7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid; EC 1.14.99.1 / Cyclooxygenase 2
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84. Polley AC, Mulholland F, Pin C, Williams EA, Bradburn DM, Mills SJ, Mathers JC, Johnson IT: Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia. Cancer Res; 2006 Jul 1;66(13):6553-62
The Lens. Cited by Patents in .

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  • Here we used two-dimensional gel electrophoresis and mass spectrometry to define patterns of protein expression in morphologically normal colonic mucosa from 13 healthy subjects, 9 patients with adenomatous polyps, and 9 with cancer.
  • Principle component analysis indicated that the first three components accounted for approximately 37% of the total variation and provided clear evidence that flat mucosa from healthy subjects differed significantly from that of patients with polyps or cancer.
  • Sixty-one proteins differed significantly between mucosa from healthy subjects and all other tissue types, and 206 differed significantly between healthy mucosa and polyp mucosa.
  • In contrast, cytokeratins, including several isoforms of cytokeratin 8, were overexpressed in apparently normal mucosa from polyp and cancer patients compared with mucosa from healthy subjects.

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  • (PMID = 16818627.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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85. Paskett ED, Reeves KW, Pineau B, Albert PS, Caan B, Hasson M, Iber F, Kikendall JW, Lance P, Shike M, Slattery ML, Weissfeld J, Kahle L, Schatzkin A, Lanza E, Polyp Prevention Trial Study Group: The association between cigarette smoking and colorectal polyp recurrence (United States). Cancer Causes Control; 2005 Nov;16(9):1021-33
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  • [Title] The association between cigarette smoking and colorectal polyp recurrence (United States).
  • OBJECTIVE: Although evidence exists linking smoking to precancerous colorectal adenomatous polyps, few studies have examined the association between cigarette smoking and recurrence of colorectal polyps.
  • This association was investigated prospectively with data from the Polyp Prevention Trial.
  • Multiple logistic regression analysis was used to examine the association between cigarette smoking and polyp recurrence (adenomatous and hyperplastic) up to four years from baseline.
  • RESULTS: Adenoma recurrence was not related to cigarette smoking.
  • Current smokers had increased odds of hyperplastic polyps at follow-up compared to never smokers (OR 2.88, 95% CI 2.06-4.01).
  • Current smoking was associated with subsequent distal (OR 3.44, 95% CI 2.38-4.95) and rectal (OR 3.53, 95% CI 2.15-5.78) hyperplastic polyps, but not subsequent proximal hyperplastic polyps.
  • Cigarette smoking was associated with subsequent multiple and small size (4 mm) hyperplastic polyps.
  • Significant linear trends were observed between development of subsequent hyperplastic polyps and all smoking variables.
  • CONCLUSIONS: Although no association with recurrent adenomas was observed, cigarette smoking was significantly associated with hyperplastic polyp development, except for those in the proximal colon.
  • This prospective study confirms that cigarette smoking has a significant effect on the development of hyperplastic colorectal polyps.
  • [MeSH-major] Colonic Polyps / pathology. Precancerous Conditions. Smoking / epidemiology
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / pathology. Aged. Colonoscopy. Epidemiologic Studies. Female. Humans. Hyperplasia / epidemiology. Hyperplasia / pathology. Male. Middle Aged. Recurrence. Risk Assessment. Risk Factors. Surveys and Questionnaires. Time Factors. United States

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  • (PMID = 16184467.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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86. Palozza P, Serini S, Maggiano N, Tringali G, Navarra P, Ranelletti FO, Calviello G: beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells. J Nutr; 2005 Jan;135(1):129-36
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  • Experimental studies have shown that beta-carotene inhibited the growth of colon cancer cells, and human trials have demonstrated that the carotenoid reduces colon cell proliferation of adenomatous polyps; however, molecular mechanisms underlying this chemopreventive activity remain unclear.
  • We evaluated the effects of beta-carotene on the growth of human colon adenocarcinoma cells overexpressing (LS-174, HT-29, WiDr) or not expressing (HCT116) COX-2.
  • This effect was not observed in cells treated with retinoic acid or retinol.
  • Moreover, cells not expressing COX-2 were insensitive to the growth-inhibitory and proapoptotic effects of the carotenoid.

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  • (PMID = 15623844.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Membrane Proteins; 0 / Neuregulin-1; 0 / Reactive Oxygen Species; 0 / heregulin alpha; 01YAE03M7J / beta Carotene; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS1 protein, human; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases; K7Q1JQR04M / Dinoprostone
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87. Kim DH, Lee SY, Choi KS, Lee HJ, Park SC, Kim J, Han CJ, Kim YC: The usefulness of colonoscopy as a screening test for detecting colorectal polyps. Hepatogastroenterology; 2007 Dec;54(80):2240-2
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  • [Title] The usefulness of colonoscopy as a screening test for detecting colorectal polyps.
  • BACKGROUND/AIMS: Colonic polyps are the most common lesions encountered during screening colonoscopy.
  • The purpose of this study is to evaluate the usefulness of colonoscopy to detect colonic polyps in adults.
  • RESULTS: Complete colonic evaluation was possible in 4,491 (97.0%) subjects, and 804 (17.9%) had adenomatous polyps, including 153 subjects (3.4%) with advanced adenomas.
  • There was a trend toward an increased prevalence of adenomatous polyps with age.
  • Among the subjects with polyps, 72.1% of the subjects had distal polyps and the relative risk for proximal polyp, according to the distal findings, was 5.4 (95% CI: 4.5-6.3) for adenomatous polyp, 5.1 (95% CI 3.6-7.0) for advanced adenoma as compared to the finding of no adenomatous polyp.
  • CONCLUSIONS: Colonoscopy performed by experienced colonoscopists as a screening test is feasible for detecting subjects with colorectal polyps.
  • [MeSH-major] Colonoscopy. Intestinal Polyps / diagnosis. Rectal Diseases / diagnosis
  • [MeSH-minor] Adult. Age Distribution. Aged. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Female. Humans. Male. Mass Screening / methods. Middle Aged. Prevalence. Sex Distribution

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  • (PMID = 18265641.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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88. Tessonnier L, Gonfrier S, Carrier P, Valerio L, Mouroux J, Benisvy D, Viau P, Girma A, Bussière F, Darcourt J: [Unexpected focal bowel 18-FDG uptake sites: should they be systematically investigated?]. Bull Cancer; 2008 Nov;95(11):1083-7

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  • We found 25 adenomatous polyps (53.2%), 10 neoplasms (21.3%) and 4 inflammatory lesions (8.5%).
  • 18-FDG uptake values were not statistically different between the 4 groups.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonic Neoplasms / metabolism. Colonic Neoplasms / radionuclide imaging. Female. Humans. Incidental Findings. Intestinal Polyps / metabolism. Intestinal Polyps / radionuclide imaging. Male. Middle Aged. Positron-Emission Tomography / methods. Rectal Neoplasms / metabolism. Rectal Neoplasms / radionuclide imaging. Retrospective Studies. Sigmoid Neoplasms / metabolism. Sigmoid Neoplasms / radionuclide imaging. Tomography, Emission-Computed. Tomography, X-Ray Computed / methods

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  • (PMID = 19036681.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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89. Giardiello FM, Hylind LM, Trimbath JD, Hamilton SR, Romans KE, Cruz-Correa M, Corretti MC, Offerhaus GJ, Yang VW: Oral contraceptives and polyp regression in familial adenomatous polyposis. Gastroenterology; 2005 Apr;128(4):1077-80
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  • [Title] Oral contraceptives and polyp regression in familial adenomatous polyposis.
  • We describe a patient in the placebo arm of a 4-year primary chemoprevention trial who developed adenomatous polyps and then had eradication of polyps after the administration of oral contraceptives.
  • No change in the prostaglandin levels in the colonic mucosa was noted after polyp elimination, making nonsteroidal anti-inflammatory drug ingestion unlikely as a cause.
  • [MeSH-major] Adenomatous Polyposis Coli / physiopathology. Contraceptives, Oral / therapeutic use

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  • (PMID = 15825088.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 51085; United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / CA 63721; United States / NCI NIH HHS / CA / P50 CA 9316
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral; 0 / Prostaglandins
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90. Benfatto G, Tenaglia L, Catania G, D'Antoni S, Jiryis A, Centoze D, Garufi SM, Mugavero F, Giovinetto A: Pathological evaluation in colorectal polyps endoscopic treatment. G Chir; 2006 Nov-Dec;27(11-12):411-6
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  • [Title] Pathological evaluation in colorectal polyps endoscopic treatment.
  • This retrospective study shows that endoscopic polypectomy is the technique of choice to remove the majority of polyps; follow-up and pathologic examinations shed light on the carcinogenesis of colorectal lesions.
  • From January 1990 to December 2001, 1302 adenomatous polyps were removed, 1175 endoscopically, 127 with surgical procedures.
  • The anatomical and morphologic conditions of the colon and some characteristics of the polyps represent limits to the feasibility and to the efficacy of polypectomy, and the most important variables for the correct management of the patients affected by colorectal adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Endoscopy

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  • (PMID = 17198549.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
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91. Liu DC, Yang ZL, Jiang S: Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma. Cancer Biomark; 2010-2011;8(3):113-21
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  • In this study, we investigated the expressions of Msi-1 and ALDH1 in gallbladder adenocarcinoma (n=100), peritumoral tissues (n=46), adenomatous polyp (n=15), and chronic cholecystitis (n=35) using immunohistochemical method.
  • The percentage of cases with positive Msi-1 and ALDH1 expression were significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues, adenomatous polyp and chronic cholecystitis (ps < 0.01).
  • [MeSH-minor] Adenomatous Polyps / metabolism. Adult. Aged. Cholecystitis / metabolism. Disease Progression. Female. Gallbladder / chemistry. Gallbladder / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Prognosis

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  • (PMID = 22012766.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / MSI1 protein, human; 0 / Nerve Tissue Proteins; 0 / RNA-Binding Proteins; EC 1.2.1.- / aldehyde dehydrogenase 1; EC 1.2.1.36 / Retinal Dehydrogenase
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92. Sousa-Júnior EC, Alencar AP, da Silva BB: Analysis of Ki-67 and Bcl-2 protein expression in normal colorectal mucosa of women with breast cancer. Eur J Cancer; 2009 Nov;45(17):3081-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to evaluate Ki-67 and Bcl-2 protein expression in the normal colorectal mucosa adjacent to adenomatous polyps in women with breast cancer.
  • A cross-sectional, controlled study was conducted in 35 women with and without breast cancer who had adenomatous colorectal polyps.
  • A sample of normal colonic mucosa was collected at a distance of 5 cm from the polypoid lesion to evaluate immunohistochemical expression of the Ki-67 and Bcl-2 proteins.
  • [MeSH-major] Adenomatous Polyposis Coli / metabolism. Breast Neoplasms / metabolism. Intestinal Mucosa / metabolism. Ki-67 Antigen / metabolism. Neoplasm Proteins / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism

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  • (PMID = 19786344.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2
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93. Clements D, Tawfiq S, Harries B, Sheridan W: Application of the BSG guidelines to a colonoscopy waiting list. Colorectal Dis; 2009 Jun;11(5):513-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • If applied less rigidly, 42% of patients should not have been on the list.
  • The reasons for removal from the list were as follows: Thirty-nine patients were older than the upper age limit, 23 had had clear colonoscopies after adenomatous polyp follow up, four were listed for diverticular disease follow up, four for metaplastic polyps, one for constipation and one for per rectum (PR) bleed follow up.
  • Conclusion With strict application of the BSG guidelines to a surveillance colonoscopy waiting list, 49% of the patients on the list do not need the procedure.

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  • (PMID = 18637926.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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94. Summers RM, Handwerker LR, Pickhardt PJ, Van Uitert RL, Deshpande KK, Yeshwant S, Yao J, Franaszek M: Performance of a previously validated CT colonography computer-aided detection system in a new patient population. AJR Am J Roentgenol; 2008 Jul;191(1):168-74
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  • OBJECTIVE: A computer-aided detection (CAD) system with high sensitivity in the detection of adenomatous polyps in varied CT colonography (CTC) data sets increases the utility of CAD in the clinical setting.
  • Most of the patients were at average risk, had CTC findings suggestive of polyps, and underwent colonoscopy.
  • In a previous non-polyp-enriched screening cohort, the standalone performance of the CAD system was 93.3% (28/30) sensitivity for adenomatous polyps 10 mm or larger, 51.1% (47/92) sensitivity for adenomas 6-9 mm, and a mean false-positive rate of 8.6 per patient.
  • RESULTS: The CAD system had per-polyp sensitivities of 91.5% (43/47; 95% CI, 78.7-97.2%; p = 1.0) for adenomas 10 mm or larger and 82.1% (32/39; 65.9-91.9%; p = 0.0009) for adenomas 6-9 mm.
  • CONCLUSION: The CAD system evaluated has a high level of performance in the detection of adenomatous polyps with CTC data from a polyp-enriched cohort different from that used to train the system.
  • [MeSH-major] Artificial Intelligence. Colonic Polyps / radiography. Colonography, Computed Tomographic / methods. Colorectal Neoplasms / radiography. Pattern Recognition, Automated / methods. Radiographic Image Interpretation, Computer-Assisted / methods

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  • (PMID = 18562741.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Intramural; Validation Studies
  • [Publication-country] United States
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95. Komarov FI, Osadchuk AM, Osadchuk MA, Kogan NIu, Kveshnoĭ IM: [Specifics of apoptotic activity and expression of regulatory molecules (Ki-67, Bcl-2) of gastric mucosal epitheliocytes, in the process of Correa's cascade]. Klin Med (Mosk); 2007;85(10):48-51
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  • The subjects of the study were 104 patients with Helicobacter pylori (HP)-associated gastric pathology, including 30 patients with gastric ulcer (GU), 30 patients with chronic atrophic gastritis (CAG), 20 patients with CAG plus adenomatous polyps (AP), and 24 patients with gastric cancer (GC).
  • [MeSH-minor] Adenomatous Polyps / metabolism. Adult. Aged. Anti-Infective Agents / therapeutic use. Atrophy / metabolism. Cell Proliferation. Epithelial Cells / metabolism. Female. Gastritis, Atrophic / metabolism. Gene Expression Regulation, Neoplastic. Humans. Male. Metaplasia / metabolism. Middle Aged. Regeneration. Stomach Ulcer / metabolism

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  • (PMID = 18154181.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2
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96. Kakar S, Deng G, Cun L, Sahai V, Kim YS: CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. Hum Pathol; 2008 Jan;39(1):30-6
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  • Aberrant methylation also occurs in serrated and adenomatous polyps.
  • BRAF V600E mutation was not observed in any tubular adenoma or tubulovillous/villous adenoma.
  • Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma.
  • [MeSH-major] Adenoma, Villous / genetics. Adenoma, Villous / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. CpG Islands. DNA Methylation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. ras Proteins / genetics
  • [MeSH-minor] Disease Progression. Humans. Microsatellite Instability

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  • (PMID = 17950780.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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97. Holten-Andersen MN, Hansen U, Brünner N, Nielsen HJ, Illemann M, Nielsen BS: Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma. Int J Cancer; 2005 Jan 10;113(2):198-206
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  • [Title] Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma.
  • Combining TIMP-1 in situ hybridization with immunohistochemical staining for alpha-smooth muscle actin or CD68 showed TIMP-1 mRNA in myofibroblasts but not in macrophages.
  • TIMP-1 mRNA was detected in 2 of 7 adenomatous polyps in the adenoma area: in both cases associated with focal stromal inflammation at the epithelial-stromal interface.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenoma / genetics. Adenoma / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Tissue Inhibitor of Metalloproteinase-1 / biosynthesis. Tissue Inhibitor of Metalloproteinase-1 / pharmacology

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  • (PMID = 15386409.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tissue Inhibitor of Metalloproteinase-1
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98. Lee GE, Park HS, Yun KE, Jun SH, Kim HK, Cho SI, Kim JH: Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men. Obesity (Silver Spring); 2008 Jun;16(6):1434-9
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  • [Title] Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men.
  • Adenomatous colonic polyps are precancerous lesions of colon cancer.
  • We investigated whether BMI and the metabolic syndrome are associated with the presence of adenomatous colonic polyps in Korean men.
  • Multiple logistic regression analysis was used to evaluate the association between BMI and the metabolic syndrome and adenomatous polyps.
  • Compared with men in the 1st quintile of the BMI, the adjusted odds ratio (OR) and 95% confidence interval (CI) for adenomatous polyps in men in the 2nd, 3rd, 4th, and 5th quintiles of the BMI were 1.55 (1.10-2.19), 1.57 (1.10-2.24), 1.94 (1.34-2.81), and 1.99 (1.31-3.01), respectively (P for trend <0.0001).
  • Men with triglycerides (TGs) > or = 150 mg/dl were significantly more likely to have adenomatous polyps than were men with TG <150 mg/dl (OR 1.29; 95% CI 1.03-1.62).
  • As a function of the number of metabolic risk factors, the ORs for adenomatous polyps were 1.41 (1.03-1.93), 1.52 (1.08-2.12), 1.46 (1.01-2.12), and 1.77 (1.08-2.90) for 1, 2, 3, and > or = 4 risk factors, respectively (P for trend <0.05).
  • Adenomatous colonic polyps were significantly associated with increased BMI levels.
  • Subjects with even one component of the metabolic syndrome had a significantly higher risk for developing adenomatous polyps compared to those subjects without any component in Korean men.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Body Mass Index. Colonic Polyps / epidemiology. Metabolic Syndrome X / physiopathology

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  • (PMID = 18388894.001).
  • [ISSN] 1930-7381
  • [Journal-full-title] Obesity (Silver Spring, Md.)
  • [ISO-abbreviation] Obesity (Silver Spring)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Triglycerides
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99. Groisman GM, Amar M, Meir A: Utility of MIB-1 (Ki-67) in evaluating diminutive colorectal polyps with cautery artifact. Arch Pathol Lab Med; 2007 Jul;131(7):1089-93
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  • [Title] Utility of MIB-1 (Ki-67) in evaluating diminutive colorectal polyps with cautery artifact.
  • CONTEXT: Accurate interpretation of colorectal polyp histology is essential in the decision-making process during treatment and surveillance following polypectomies.
  • However, interpretation of diminutive colorectal polyps removed by thermal electrocoagulation (hot biopsy technique) is often problematic as a result of cautery artifact.
  • OBJECTIVE: To evaluated the usefulness of the proliferation marker MIB-1 (Ki-67) as an aid in the differential diagnosis of diminutive colorectal polyps with cautery artifact, as adenomatous and nonadenomatous polyps display different patterns of epithelial proliferation.
  • DESIGN: Seventy-five diminutive colorectal polyps with extensive cautery artifact displaying at least the upper portions of 3 adjacent crypts with the corresponding surface epithelium were evaluated and immunolabeled with MIB-1.
  • They included 25 cases in which a definitive or presumptive diagnosis could not be reached (indeterminate polyps), 25 cases diagnosed as compatible with adenomatous polyp, and 25 cases diagnosed as compatible with nonadenomatous polyp.
  • Among indeterminate polyps, MIB-1 stained upper crypts and surface epithelium in 14 cases (adenomatous polyp staining pattern) and revealed minimal or absent staining in these areas in 11 cases (nonadenomatous polyp staining pattern).
  • All cases diagnosed as compatible with adenomatous polyp displayed the adenomatous polyp staining pattern.
  • In contrast, all cases diagnosed as compatible with nonadenomatous polyp revealed the nonadenomatous polyp staining pattern.
  • CONCLUSIONS: Immunoreactivity for MIB-1 may be used as a beneficial adjunctive test to help diagnose diminutive colorectal polyps with extensive cautery artifact.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Intestinal Polyps / diagnosis. Ki-67 Antigen / analysis. Rectal Diseases / diagnosis

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  • (PMID = 17616996.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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100. Cappell MS: The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps. Med Clin North Am; 2005 Jan;89(1):1-42, vii
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  • [Title] The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps.
  • A review of the pathophysiology, clinical presentation, and diagnosis of colon cancer and colonic polyps is important and timely.
  • This article reviews colon cancer and colonic polyps, with a focus on recent dramatic advances, to help the pri-mary care physician and internist appropriately refer patients for screening colonoscopy and intelligently evaluate colonoscopic findings to reduce the mortality from this cancer.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / physiopathology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / physiopathology

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  • (PMID = 15527807.001).
  • [ISSN] 0025-7125
  • [Journal-full-title] The Medical clinics of North America
  • [ISO-abbreviation] Med. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 251
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