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1. Ihtiyar E, Algin C, Isiksoy S, Ates E: Small cell carcinoma of rectum: a case report. World J Gastroenterol; 2005 May 28;11(20):3156-8
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  • By colonoscopy, polyps were determined in the rectum and biopsies were carried out.
  • Histopathologically, the polyps were adenomatous.

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  • (PMID = 15918209.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4305859
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2. Xu HX: Contrast-enhanced ultrasound in the biliary system: Potential uses and indications. World J Radiol; 2009 Dec 31;1(1):37-44

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  • The use of contrast-enhanced US (CEUS) has reached the field of bile duct disease in recent years and promising results have been achieved.
  • (4) To detect malignant change in Caroli's disease;.
  • (6) To make a distinction between gallbladder cholesterol polyp, adenoma and polypoid cancer;.

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  • (PMID = 21160719.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999303
  • [Keywords] NOTNLM ; Bile duct / Cholangiocarcinoma / Contrast-enhanced ultrasound / Gallbladder / Polypoid lesion / Ultrasound contrast agent
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3. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • [Title] Analysis of mtDNA sequence variants in colorectal adenomatous polyps.
  • Colorectal tumors mostly arise from sporadic adenomatous polyps.
  • Polyps are defined as a mass of cells that protrudes into the lumen of the colon.
  • Adenomatous polyps are benign neoplasms that, by definition display some characteristics of dysplasia.
  • It has been shown that polyps were benign tumors which may undergo malignant transformation.
  • Adenomatous polyps have been classified into three histologic types; tubular, tubulovillous, and villous with increasing malignant potential.
  • The ability to differentially diagnose these colorectal adenomatous polyps is important for therapeutic intervention.
  • To date, little efforts have been directed to identifying genetic changes involved in adenomatous polyps.
  • This study was designed to examine the relevance of mitochondrial genome alterations in the three adenomatous polyps.
  • Using high resolution restriction endonucleases and PCR-based sequencing, fifty-seven primary fresh frozen tissues of adenomatous polyps (37 tumors and 20 matched surrounding normal tissues) obtained from the southern regional Cooperative Human Tissue Network (CHTN) and Grady Memorial Hospital at Atlanta were screened with three mtDNA regional primer pairs that spanned 5.9 kbp.
  • Notably, a heteroplasmic variant C8515G/T in the MT-ATP 8 gene and a germline variant 8327delA in the tRNAlys was observed in all the tissue samples of the three adenomatous polyps in comparison to the referenced database sequence.
  • Our current data provide a basis for continued investigation of certain mtDNA variants as predictors of the three adenomatous polyps in a larger number of clinicopathological specimens.
  • [MeSH-major] Adenomatous Polyps / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. DNA, Mitochondrial / analysis. Genetic Variation
  • [MeSH-minor] Aged. Biopsy. DNA Mutational Analysis. Databases, Genetic. Disease Progression. Humans. Middle Aged. Polymerase Chain Reaction. Prognosis

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  • [Cites] Am J Surg Pathol. 2004 Nov;28(11):1460-5 [15489649.001]
  • [Cites] Science. 1987 Oct 9;238(4824):193-7 [2889267.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Gastroenterology. 1990 Feb;98(2):371-9 [2403953.001]
  • [Cites] Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11164-8 [1454794.001]
  • [Cites] FEBS Lett. 1995 Jan 16;358(1):1-3 [7821417.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9 [9012815.001]
  • [Cites] Mol Cancer. 2004 Oct 13;3:30 [15482594.001]
  • [Cites] Cancer Res. 2005 Mar 1;65(5):1655-63 [15753359.001]
  • [Cites] Br J Cancer. 2005 Aug 8;93(3):331-7 [15956973.001]
  • [Cites] Science. 2008 May 2;320(5876):661-4 [18388260.001]
  • [Cites] Diagn Mol Pathol. 2008 Jun;17(2):94-100 [18382370.001]
  • [Cites] Carcinogenesis. 2010 Feb;31(2):296-301 [19945968.001]
  • [Cites] Hum Pathol. 2002 Mar;33(3):372-5 [11979380.001]
  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
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4. Liu YH, Lin J, Guo J, You ZJ, Wang ZG, Zhong D, Yang XL, Zhang ZS, Xiao B, Guo WY: [Detection of interferon-induced transmembrane-1 gene expression for clinical diagnosis of colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Nov;28(11):1950-3
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  • METHODS: Semi-quantitative RT-PCR was performed to detect IFITM1 mRNA expression in the specimens of normal colonic mucosa, CRC tissue, inflammatory polyps, adenomatous polyps, gastric cancer, esophageal carcinoma and liver cancer tissues.
  • RESULTS: IFITM1 mRNA was expressed in 47.4 % (18/38) of the CRC specimens, a rate significantly higher than that in adenomatous polyps [15% (3/20)] and gastric cancer [4.8% (1/21)]; no obvious IFITM1 expression was found in normal colonic mucosa, inflammatory polyp, esophageal carcinoma or liver cancer tissues (P<0.001 or P<0.05).
  • IFITM1 mRNA was strongly expressed in CRC at the expression level of 0.8048-/+0.2273, which was significantly higher than that in adenomatous polyps (0.4447-/+0.0989, P<0.001).
  • No antibody response was detected in esophageal carcinoma, liver cancer, inflammatory polyp or adenomatous polyps.

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  • (PMID = 19033100.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Differentiation; 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / leu-13 antigen
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5. Arber N, Eagle CJ, Spicak J, Rácz I, Dite P, Hajer J, Zavoral M, Lechuga MJ, Gerletti P, Tang J, Rosenstein RB, Macdonald K, Bhadra P, Fowler R, Wittes J, Zauber AG, Solomon SD, Levin B, PreSAP Trial Investigators: Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med; 2006 Aug 31;355(9):885-95
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  • [Title] Celecoxib for the prevention of colorectal adenomatous polyps.
  • BACKGROUND: Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting researchers to propose its inhibition as a chemopreventive intervention.
  • METHODS: The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, placebo-controlled, double-blind study of the COX-2 inhibitor celecoxib given daily in a single 400-mg dose.
  • Of the 557 subjects in the placebo group and the 840 subjects in the celecoxib group who were included in the efficacy analysis, 264 and 270, respectively, were found to have at least one adenoma at year 1, at year 3, or both.
  • [MeSH-major] Adenoma / prevention & control. Adenomatous Polyps / drug therapy. Colorectal Neoplasms / prevention & control. Cyclooxygenase 2 Inhibitors / therapeutic use. Pyrazoles / therapeutic use. Sulfonamides / therapeutic use

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  • [Copyright] Copyright 2006 Massachusetts Medical Society.
  • [CommentIn] N Engl J Med. 2006 Nov 30;355(22):2371; author reply 2371-3 [17135594.001]
  • [CommentIn] N Engl J Med. 2006 Aug 31;355(9):950-2 [16943408.001]
  • (PMID = 16943401.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00141193
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib; R16CO5Y76E / Aspirin
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6. Powers HJ, Hill MH, Welfare M, Spiers A, Bal W, Russell J, Duckworth Y, Gibney E, Williams EA, Mathers JC: Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study). Cancer Epidemiol Biomarkers Prev; 2007 Oct;16(10):2128-35
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  • [Title] Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).
  • A double-blind randomized placebo-controlled intervention study (the FAB2 Study) was carried out in healthy controls and patients with colorectal polyps (adenomatous and hyperplastic) to examine effects of folic acid and riboflavin supplements on biomarkers of nutrient status and on putative biomarkers of colorectal cancer risk (DNA methylation and DNA damage; to be reported elsewhere).
  • Ninety-eight healthy controls and 106 patients with colorectal polyps were stratified for the thermolabile variant of methylene tetrahydrofolate reductase, MTHFR C677T, and were randomized to receive 400 microg of folic acid, 1,200 microg of folic acid, or 400 microg of folic acid plus 5 mg of riboflavin or placebo for 6 to 8 weeks.
  • Riboflavin supplement enhanced the response to low-dose folate in people carrying at least one T allele and having polyps.
  • The magnitude of the response in mucosal folate was positively related to the increase in plasma 5-methyl tetrahydrofolate but was not different between the healthy group and polyp patients.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Biomarkers, Tumor / blood. Folic Acid / administration & dosage. Folic Acid / blood. Riboflavin / administration & dosage. Riboflavin / blood

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  • (PMID = 17932361.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tetrahydrofolates; 0LVT1QZ0BA / Homocysteine; 134-35-0 / 5-methyltetrahydrofolate; 935E97BOY8 / Folic Acid; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); TLM2976OFR / Riboflavin
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7. Kil Lee S, Il Kim T, Kwan Shin S, Ho Kim W, Kim H, Kyu Kim N: Comparison of the clinicopathologic features between flat and polypoid adenoma. Scand J Gastroenterol; 2008;43(9):1116-21
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  • [Title] Comparison of the clinicopathologic features between flat and polypoid adenoma.
  • OBJECTIVE: Several reports have suggested that flat colorectal adenomas might exhibit a higher potential for malignancy compared to polypoid adenomas.
  • Although the clinical importance of the shape of polyps is stressed, the controversy surrounding the malignant potential of flat adenomas continues.
  • The aim of this study was to compare the clinicopathologic characteristics, including degree of dysplasia and malignancy, between flat and polypoid adenomas 5 mm in size or larger.
  • MATERIAL AND METHODS: A total of 3263 polyps (254 flat adenomas and 3009 polypoid adenomas), >/=5 mm in size, diagnosed in 1883 patients by colonoscopy were analyzed.
  • The flat adenomas were larger in diameter than the polypoid adenomas (14.8+/-12.6 mm versus 8.6+/-5.0 mm, p <0.01), had a higher rate of villous components (18.5% versus 11.4%, p <0.01), a higher rate of high-grade dysplasia (9.4% versus 4.2%, p <0.01), and a higher rate of malignancy (10.2% versus 3.6%, p <0.01) than polypoid adenomas.
  • However, there was no difference in the rate of high-grade dysplasia or carcinoma between flat and polypoid adenomas of equal size.
  • It was shown by multivariate analysis that rectosigmoid location, larger size, and presence of a villous component were associated with a higher rate of malignancy, but not with flat morphology.
  • CONCLUSIONS: Flat adenomas, which were of a relatively large size in this study, were not associated with a higher risk for high-grade dysplasia and carcinoma compared with polypoid adenomas.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 18609172.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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8. Speake D, Biyani D, Frizelle FA, Watson AJ: Flat adenomas. ANZ J Surg; 2007 Jan-Feb;77(1-2):4-8
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  • The adenoma-carcinoma sequence describes a succession of events from polypoid adenoma to colorectal cancer.
  • There is growing evidence that flat adenomas are precursor lesions to a flat type of colorectal cancer and certain subtypes of these polyps are at greater risk of malignant transformation.
  • [MeSH-major] Adenocarcinoma / physiopathology. Adenoma / physiopathology. Colonic Neoplasms / physiopathology. Colonic Polyps / physiopathology

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  • (PMID = 17295810.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 72
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9. Tao S, Lu Q, Jiang B: [The clinical significance of colorectal flat lesions under endoscopy]. Zhonghua Yi Xue Za Zhi; 2007 May 29;87(20):1417-9
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  • OBJECTIVE: To identify flat lesion in colon and rectum with combination of magnifying endoscope and mucosa staining technique ad to compare the differences between the protruded and flat colorectal lesions.
  • (1) A total of 1472 adenoma cases were found; 154 (10.46%) of which were of the flat type. (2) The average size of flat adenoma was (17 +/- 14) mm, significantly smaller than that of polypoid adenoma [(29 +/- 9) mm, P < 0.05)]. (3) The incidence of colorectal tumor in the left colon was 82.35% (140/170) in the flat type tumor, significantly higher than that in the protruded type tumors (79.59%, 1630/2048, P = 0.013). (4) The incidence rates of tubular adenoma, tubulo-villous adenoma, villous adenoma, and cancer were 51.34%, 4.25%, 8.79%, and 35.65% respectively in the protruded type tumor, and were 55.55%, 17.06%, 17.64%, and 9.43% respectively.
  • CONCLUSION: The detection rates of moderate and severe dysplasia and early colorectal cancer in the flat adenomas are higher than in the protruded adenoma.
  • Of higher malignancy grade, flat adenomatous lesions are more likely to be carcinomatous compared with the protruded adenomatous lesions.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / epidemiology. Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / epidemiology. Adolescent. Adult. Aged. Aged, 80 and over. China / epidemiology. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Diagnosis, Differential. Humans. Incidence. Middle Aged

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  • (PMID = 17785067.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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10. Parra V, Watanabe J, Nago A, Astete M, Rodríguez C, Valladares G, Nuñez N, Yoza M, Gargurevich T, Pinto Sánchez J: [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy]. Rev Gastroenterol Peru; 2009 Oct-Dec;29(4):326-31
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  • [Title] [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy].
  • [Transliterated title] Papel del Endoscopista en la Detección de Pólipos Adenomatosos Durante la Colonoscopia.
  • INTRODUCTION: Age, gender and indication for the examination are known predictors of adenomatous polyp detection during colonoscopy.
  • OBJECTIVES: To determine the role of the endoscopist in detecting adenomatous polyps during colonoscopy MATERIAL AND METHODS: Is retrospective cross-sectional correlational study.
  • Statistical analysis showed significant differences between endoscopists regarding the detection rate of adenomatous polyps (p = 0.038).
  • The range for the detection of at least 1 adenomatous polyp by colonoscopy was 14,6-30,0%.
  • In patients over 50 years, there were also significant differences between endoscopists in detection rate of adenomatous polyps (p = 0.001).
  • The range for the detection of at least 1 adenomatous polyp was 18,2-37,5% in that group.Also found that age and gender were powerful predictors of adenomatous polyps, both for the total cohort, and patients older than 50 years.
  • Regarding the indication for colonoscopy, no significant difference between the categories, were found p = 0.288 CONCLUSION S: The endoscopist is as or more important than age, gender or indication for the examination, in predicting the detection of adenomatous polyps during colonoscopy.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonoscopy / standards

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  • (PMID = 20066017.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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11. Parfitt JR, Shepherd NA: Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp! Histopathology; 2008 Jul;53(1):91-6
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  • [Title] Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp!
  • AIMS: Polypoid mucosal prolapse near the anorectal junction mimics adenomas endoscopically and histopathologically.
  • The aim was to describe the phenomenon of polypoid mucosal prolapse arising secondary to adenomas at the anorectal junction.
  • METHODS AND RESULTS: Four cases of low rectal adenoma with polypoid mucosal prolapse were assessed histopathologically, as well as with p53 and Ki67 antibodies.
  • CONCLUSIONS: Histopathologists must recognize the potential for adenomatous/dysplastic foci in anorectal lesions to superficially resemble inflammatory cloacogenic polyps.
  • We believe that polypoid mucosal prolapse changes can be a secondary phenomenon, due to adenomas close to or at the anorectal junction.
  • [MeSH-major] Adenoma / pathology. Intestinal Mucosa / pathology. Intestinal Polyps / diagnosis. Rectal Neoplasms / pathology. Rectal Prolapse / pathology. Rectum / pathology

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  • (PMID = 18484980.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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12. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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13. Park SY, Kim BC, Shin SJ, Lee SK, Kim TI, Kim WH: Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years. Hepatogastroenterology; 2009 May-Jun;56(91-92):677-81
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  • [Title] Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years.
  • BACKGROUND/AIMS: Several reports have suggested a trend of right-side shift of colorectal cancer; however, there were only a few studies on the chronologic changes in the distribution of adenomatous polyps.
  • We aimed to study the changes in the distribution of colorectal adenomatous polyps over the past ten years.
  • Patients who had an adenomatous polyp with a diameter of at least 5mm were included.
  • Of these, patients with a history of colon resection, colorectal cancer, colorectal polyp, inflammatory bowel disease, HNPCC, or familial adenomatous polyposis were excluded.
  • RESULTS: A total of 2,498 patients and 4,591 adenomatous polyps were included in this study.
  • Analysis with respect to number of patients showed significant increases in the proportion of patients with adenomatous polyp on the proximal colon, from 48.5% to 66.3% (p<0.001).
  • Analysis with respect to number of polyps revealed that the proportion of adenomatous polyps on the proximal colon significantly increased from 48.9% to 62.3% (p<0.001).
  • CONCLUSIONS: The proportion of adenomatous polyp on the proximal colon significantly increased over the past 10 years.
  • [MeSH-major] Adenomatous Polyposis Coli / ethnology. Adenomatous Polyposis Coli / pathology. Asian Continental Ancestry Group / statistics & numerical data

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  • (PMID = 19621679.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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14. Kurland JE, Beck SE, Solomon CJ, Brann OS, Carethers JM, Huang SC: Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A. J Pediatr Gastroenterol Nutr; 2007 Mar;44(3):318-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A.
  • OBJECTIVES: Cyclooxygenase-2 (COX-2) expression is increased in colorectal cancers and has been reported to be upregulated in Peutz-Jeghers polyps.
  • To determine whether germline and somatic loss of BMPR1A in polyps from a patient with juvenile polyposis syndrome have altered COX-2 expression, we characterized a patient with juvenile polyposis syndrome for BMPR1A germline mutations and examined the polyps for BMPR1A expression and COX-2 expression.
  • Multiple polypectomies were performed, and several polyps showed adenomatous change.
  • Genomic DNA was extracted from polyp material for loss of heterozygosity (LOH) analyses with microsatellite markers.
  • In polyp domains containing cystic and adenomatous epithelium, no LOH was observed using markers near the BMPR1A locus.
  • Immunostaining indicated decreased expression of phospho-SMAD1 (pSMAD1), functionally downstream of the mutant BMPR1A receptor in the cystic epithelium, with further reduction in adenomatous portions within the polyp.
  • COX-2 protein, normally not expressed in the colon, was present and increased in polyp epithelium.
  • CONCLUSIONS: Decreased expression of pSMAD1 in the cystic epithelium with further reduction in the adenomatous area, and increase in COX-2 expression within polyps from the BMPR1A heterozygote, suggest a potential mechanism for adenomatous pathogenesis in these hamartomatous polyps.

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  • (PMID = 17325551.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090231-05; United States / NIDDK NIH HHS / DK / T32 DK007202-32; United States / NCI NIH HHS / CA / R01 CA090231-05; United States / NCI NIH HHS / CA / R01 CA090231; United States / NCI NIH HHS / CA / R01-CA90231; United States / NIDDK NIH HHS / DK / K08-DK64560A; United States / NIDDK NIH HHS / DK / T32 DK007202; United States / NIDDK NIH HHS / DK / DK007202-32
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Smad1 Protein; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.30 / BMPR1A protein, human; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I
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15. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev; 2005;(3):CD003548
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps.
  • Experimental and epidemiological evidence has been suggestive but not conclusive for a protective role for high dietary calcium intake.
  • Intervention studies with colorectal cancer as an endpoint are difficult to perform owing to the large number of patients and the long follow-up required; studies using the appearance of colorectal adenomatous polyps as a surrogate endpoint are therefore considered in reviewing the existing evidence.
  • OBJECTIVES: This systematic review aims to assess the effect of supplementary dietary calcium on the incidence of colorectal cancer and the incidence or recurrence of adenomatous polyps.
  • SELECTION CRITERIA: Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in humans are reviewed.
  • Studies of healthy adults and studies of adults at higher risk of colon cancer due to family history, previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are excluded.
  • For the development of recurrent colorectal adenoma, a reduction was found (OR 0.74, CI 0.58,0.95) when the results from both trials were combined.
  • AUTHORS' CONCLUSIONS: Although the evidence from two RCTs suggests that calcium supplementation might contribute to a moderate degree to the prevention of colorectal adenomatous polyps, this does not constitute sufficient evidence to recommend the general use of calcium supplements to prevent colorectal cancer.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Calcium, Dietary / therapeutic use. Colorectal Neoplasms / prevention & control. Dietary Supplements
  • [MeSH-minor] Adenoma / complications. Humans. Randomized Controlled Trials as Topic


16. Zhou PH, Yao LQ, Chen WF: [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum]. Zhonghua Wai Ke Za Zhi; 2008 Sep 15;46(18):1386-9
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  • [Title] [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum].
  • OBJECTIVE: To assess the clinical efficacy of endoscopic treatment for colorectal adenomatous polyps and early-stage carcinomas.
  • METHODS: Between January 2006 and October 2007, 245 patients with colorectal adenomatous polyps and early-stage carcinomas with lifting sign(+) were treated by such endoscopic techniques as polypectomy, endoscopic mucosal resection (EMR), endoscopic piecemeal mucosal resection (EPMR) and endoscopic submucosal dissection (ESD).
  • CONCLUSIONS: Endoscopic resection appears to be an efficacious procedure to treat adenomatous polyp and early-stage carcinoma and provide pathological information about the whole lesion.
  • [MeSH-major] Adenomatous Polyps / surgery. Colorectal Neoplasms / surgery. Endoscopes, Gastrointestinal

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  • (PMID = 19094508.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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17. Glazer E, Golla V, Forman R, Zhu H, Levi G, Bodenheimer HC Jr: Serrated adenoma is a risk factor for subsequent adenomatous polyps. Dig Dis Sci; 2008 Aug;53(8):2204-7
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  • [Title] Serrated adenoma is a risk factor for subsequent adenomatous polyps.
  • BACKGROUND: Serrated adenomas (SA) are histologically defined by the presence of both hyperplastic and adenomatous features.
  • These uncommon polyps are thought to play an important role in the development of sporadic colorectal cancers (CRC) with microsatellite instability (MSI).
  • There is paucity of data on the risk of progression of SA to CRC.
  • This study was undertaken to define the relationship between SA and the future development of adenomatous polyps.
  • METHODS: Colonoscopic biopsies that contained a pathologic diagnosis of SA were identified from a pathology database of a major urban academic medical center.
  • These were matched to controls by age, sex, indication for colonoscopy, polyp type and number and duration of follow-up.
  • Of these, 80 patients (0.5%) with SA were found, and of these SA, 80% were found in the left colon.
  • The average age of patients undergoing colonoscopy was 58.5 years, and the average age of patients with SA was 68 years (P = 0.004).
  • Of all patients with SA, 7 (9%) had concomitant CRC.
  • On follow-up examination four patients (24%) and no controls had adenomatous polyps (P = 0.01).
  • CONCLUSIONS: While SA are uncommon, they are commonly associated with colorectal cancer.
  • This study found a significant association between SA and the subsequent development of adenomatous polyps.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Aged. Case-Control Studies. Colonoscopy. Disease Progression. Female. Humans. Hyperplasia. Male. Middle Aged. Retrospective Studies. Risk Factors

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  • (PMID = 18320324.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Erdem L, Akbayir N, Yildirim S, Köksal HM, Yenice N, Gültekin OS, Sakiz D, Peker O: Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon. Turk J Gastroenterol; 2005 Dec;16(4):207-11
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  • [Title] Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon.
  • The necessity of colonoscopy in patients with an adenoma of<or=5 mm found on sigmoidoscopy is controversial.
  • METHODS: Patients found to have rectosigmoid adenomatous polyps on colonoscopy were included in the study.
  • These adenomas were grouped as diminutive (<or=5 mm), small (6-10 mm) or large (>or=11 mm) polyps.
  • These groups were compared regarding the presence of proximal adenoma and advanced proximal neoplasia (>10 mm adenoma and/or villous histology and/or high grade dysplasia or cancer).
  • Polyps found in the rectum and sigmoid colon were considered as distal polyps and polyps other than these were considered as proximal polyps.
  • RESULTS: In this study, of 1124 consecutive patients who underwent colonoscopy between April 1997 and January 2002, 184 (16%) had 258 adenomatous polyps in the rectosigmoid area.
  • The polyps were diminutive (<or=5 mm) in 105, small (6-10 mm) in 46 and large (>or=11 mm) in 33 patients.
  • Forty-one of the patients (39%) with diminutive polyps, 20 of the patients (43%) with small polyps and 19 of the patients (57%) with large polyps had neoplasm in the proximal bowel.
  • The rate of advanced proximal neoplasm was found to be significantly higher in the group with large polyps in the rectosigmoid area than in the groups with small and diminutive polyps (p<0.05).
  • In 104 patients (57%) with polyp(s) in rectum and sigmoid colon, no associated polyp or cancer was encountered in the proximal colon.
  • CONCLUSION: Colonoscopy is indicated when adenomatous polyp, regardless of size, is found on rectosigmoidoscopy performed because of symptoms.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neoplasms, Multiple Primary. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 16547849.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Turkey
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19. Kim BJ, Kim YH, Sinn DH, Kang KJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC: Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males. Cancer Causes Control; 2010 Jun;21(6):939-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males.
  • RESULTS: Subjects in their 50 s had significantly more adenomatous polyps than subjects in their 40 s (32.7% vs. 26.0%, p < 0.05).
  • The incidence of adenomatous polyp increased with increasing quartiles of HbA1C as follows: first quartile (19.9%, HbA1c 4.0-5.0), second quartile (27.8%, HbA1c 5.1-5.3), third quartile (32.7%, HbA1c 5.4-5.5), and fourth quartile (34.9%, HbA1c = 5.6-8.8)(p = 0.008).
  • When combining quartile of HbA1c and age (40 s vs. 50 s) according to HbA1C levels, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c <5.4% was significantly lower than that in subjects in their 50 s.
  • However, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c > or =5.4% was similar to that in subjects in their 50 s with average risk for CRC.
  • CONCLUSIONS: An elevated HbA1c may be useful as a clinical predictor of adenomatous polyps in male subjects <50 years of age who have average risk for CRC.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology

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  • (PMID = 20373014.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hemoglobin A, Glycosylated
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20. Kim H, Kim HJ, Chi SG, Lee SK, Joo GR, Dong SH, Kim BH, Chang YW, Lee JI, Chang R: Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea. World J Gastroenterol; 2006 Feb 14;12(6):951-5
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  • [Title] Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea.
  • AIM: Recently, germ-line mutation in the base excision repair gene MYH has been identified to cause a novel autosomal recessive form of familial adenomatous polyposis (FAP).
  • In this study, we screened 30 patients with multiple adenomatous polyps for MYH mutations to assess its prevalence and ethnic specificity in Korea.
  • METHODS: Thirty patients (21 men and 9 women; mean age 62.3 years) with multiple adenomatous polyps were examined for MYH mutations.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Mutation

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  • [Cites] Cancer Res. 2003 Nov 15;63(22):7595-9 [14633673.001]
  • [Cites] Lancet. 2003 Jul 5;362(9377):5-6 [12853190.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):533-7 [2841598.001]
  • [Cites] Nature. 1991 Jan 31;349(6308):431-4 [1992344.001]
  • [Cites] Ann Hum Genet. 1992 May;56(Pt 2):99-103 [1503398.001]
  • [Cites] J Bacteriol. 1992 Oct;174(20):6321-5 [1328155.001]
  • [Cites] Nature. 1993 Apr 22;362(6422):709-15 [8469282.001]
  • [Cites] Mol Gen Genet. 1993 May;239(1-2):72-6 [8510665.001]
  • [Cites] J Biol Chem. 1993 Nov 5;268(31):23524-30 [8226881.001]
  • [Cites] Mol Cell Biol. 1995 Feb;15(2):989-96 [7823963.001]
  • [Cites] Pathol Biol (Paris). 1996 Jan;44(1):6-13 [8734294.001]
  • [Cites] Mol Gen Genet. 1997 Mar 26;254(2):171-8 [9108279.001]
  • [Cites] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8016-20 [9223306.001]
  • [Cites] Oncogene. 1998 Jun 25;16(25):3219-25 [9681819.001]
  • [Cites] Mutat Res. 1998 May 25;400(1-2):99-115 [9685598.001]
  • [Cites] Nucleic Acids Res. 1999 Sep 15;27(18):3638-44 [10471731.001]
  • [Cites] Nucleic Acids Res. 2000 Mar 15;28(6):1355-64 [10684930.001]
  • [Cites] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514.001]
  • [Cites] Hum Mol Genet. 2000 Sep 22;9(15):2215-21 [11001924.001]
  • [Cites] Int J Cancer. 2000 Dec 15;88(6):932-7 [11093817.001]
  • [Cites] Hum Mol Genet. 2001 Apr;10(7):721-33 [11257105.001]
  • [Cites] Cancer Lett. 2001 Sep 10;170(1):53-61 [11448535.001]
  • [Cites] Nat Genet. 2002 Feb;30(2):227-32 [11818965.001]
  • [Cites] Hum Mol Genet. 2002 Nov 1;11(23):2961-7 [12393807.001]
  • [Cites] N Engl J Med. 2003 Feb 27;348(9):791-9 [12606733.001]
  • [Cites] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2709-13 [3128795.001]
  • (PMID = 16521226.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC4066163
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21. Kim JH, Lee SY, Kim BK, Choe WH, Kwon SY, Sung IK, Park HS, Jin CJ: Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy. World J Gastroenterol; 2008 Mar 28;14(12):1903-7
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  • [Title] Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy.
  • AIM: To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy.
  • METHODS: Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision.
  • Both pre- and post-sprayed images were shown to 16 examiners, who were asked to interpret the lesions as either hyperplastic or adenomatous polyps.
  • Regression analysis demonstrated that surrounding colonic mucosa was the only factor that was significantly related to accuracy in discriminating adenomatous from hyperplastic polyps (P < 0.001).
  • Accuracy was higher for polyps with linear surrounding colonic mucosa than for those with nodular surrounding colonic mucosa (P < 0.001), but was not related to the shape, location, or size of the polyp.
  • CONCLUSION: The accuracy of predicting histology is significantly related to the pattern of colonic mucosa surrounding the polyp.
  • Making a histological diagnosis of colon polyps merely by acetic acid spray is helpful for colon polyps with linear, regularly patterned surrounding colonic mucosa, and less so for those with nodular, irregularly patterned surrounding colonic mucosa.
  • [MeSH-major] Acetic Acid. Adenomatous Polyps. Colonic Polyps. Endoscopy / methods. Hyperplasia. Intestinal Mucosa

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  • [Cites] Gastrointest Endosc. 2003 Jan;57(1):48-53 [12518130.001]
  • [Cites] Endoscopy. 2003 May;35(5):437-45 [12701018.001]
  • [Cites] Ann Surg. 1987 Jun;205(6):659-64 [3592808.001]
  • [Cites] Gastroenterology. 1996 Apr;110(4):1253-8 [8613016.001]
  • [Cites] Gastrointest Endosc. 1996 Jul;44(1):8-14 [8836710.001]
  • [Cites] Endoscopy. 2004 Dec;36(12):1089-93 [15578300.001]
  • [Cites] Gastrointest Endosc. 2002 May;55(6):687-94 [11979251.001]
  • [Cites] Gastrointest Endosc. 2006 May;63(6):824-8 [16650546.001]
  • [Cites] World J Gastroenterol. 2006 Apr 21;12(15):2402-5 [16688833.001]
  • [Cites] Gastrointest Endosc. 2006 Jun;63(7):1010-7 [16733118.001]
  • [Cites] CA Cancer J Clin. 2006 May-Jun;56(3):143-59; quiz 184-5 [16737947.001]
  • [Cites] Endoscopy. 2006 Jun;38(6):613-6 [16612744.001]
  • [Cites] Gastrointest Endosc. 2006 Jul;64(1):13-6 [16813796.001]
  • [Cites] World J Gastroenterol. 2006 Mar 7;12(9):1416-20 [16552812.001]
  • (PMID = 18350630.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] Q40Q9N063P / Acetic Acid
  • [Other-IDs] NLM/ PMC2700415
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22. Weingarten MA, Zalmanovici A, Yaphe J: Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev; 2008;(1):CD003548
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps.
  • Experimental and epidemiological evidence has been suggestive but not conclusive for a protective role for high dietary calcium intake.
  • Intervention studies with colorectal cancer as an endpoint are difficult to perform owing to the large number of patients and the long follow-up required; studies using the appearance of colorectal adenomatous polyps as a surrogate endpoint are therefore considered in reviewing the existing evidence.
  • OBJECTIVES: This systematic review aims to assess the effect of supplementary dietary calcium on the incidence of colorectal cancer and the incidence or recurrence of adenomatous polyps.
  • SELECTION CRITERIA: Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in humans are reviewed.
  • Studies of healthy adults and studies of adults at higher risk of colon cancer due to family history, previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are excluded.
  • For the development of recurrent colorectal adenoma, a reduction was found (OR 0.74, CI 0.58,0.95) when the results from both trials were combined.
  • AUTHORS' CONCLUSIONS: Although the evidence from two RCTs suggests that calcium supplementation might contribute to a moderate degree to the prevention of colorectal adenomatous polyps, this does not constitute sufficient evidence to recommend the general use of calcium supplements to prevent colorectal cancer.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Calcium, Dietary / therapeutic use. Colorectal Neoplasms / prevention & control. Dietary Supplements
  • [MeSH-minor] Adenoma / complications. Humans. Randomized Controlled Trials as Topic


23. Kim CS, Kim MC, Cheong HK, Jeong TH: [The association of obesity and left colonic adenomatous polyps in Korean adult men]. J Prev Med Public Health; 2005 Nov;38(4):415-9
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  • [Title] [The association of obesity and left colonic adenomatous polyps in Korean adult men].
  • OBJECTIVES: We wanted to evaluate the relationship between obesity and left colonic adenomatous polyps in Korean adult men.
  • RESULTS: There were 99 cases of colonic adenomatous polyps.
  • The BMI and WHR were associated with the adenomatous polyps (odds ratio, 1.81 [95% CI=1.02-3.19] for a BMI > or = 25.0 as compared with a BMI < or = 22.9, odds ratio, 3.94 [95% CI = 1.77-8.77] for a WHR > or = 0.95 as compared with a WHR < or = 0.86).
  • The BMI was not associated with the risk of adenomatous polyps after additional adjustment was made for the WHR, but the association between the WHR and adenomatous polyps was still positive and independent of the BMI (odds ratio, 4.15 [95% CI=1.63-10.59]).
  • CONCLUSIONS: The results support that obesity, and particularly abdominal obesity, can be associated with an increased risk of incurring colonic adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / etiology. Colonic Polyps / etiology. Obesity / complications

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  • (PMID = 16358826.001).
  • [ISSN] 1975-8375
  • [Journal-full-title] Journal of preventive medicine and public health = Yebang Ŭihakhoe chi
  • [ISO-abbreviation] J Prev Med Public Health
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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24. Oset P, Jasińska A, Szcześniak P, Orszulak-Michalak D, Talar-Wojnarowska R, Małecka-Panas E: [Analysis of serum gastrin levels in patients with adenomatous polyps of the colon]. Pol Merkur Lekarski; 2009 May;26(155):458-61

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of serum gastrin levels in patients with adenomatous polyps of the colon].
  • Adenomatous polyps are known risk factor of colon cancer.
  • Gastrin is a peptide hormone involved in the growth of both normal and malignant intestinal tissue, which probably may promote progression through the adenoma-carcinoma sequence.
  • MATERIAL AND METHODS: The study included 60 patients with adenomatous polyps of the colon and 30 healthy volunteers.
  • There was no association between gastrin levels and size, number, localisation and histologic type of polyps (p > 0.05).
  • CONCLUSION: Despite of elevated serum levels in patients with colonic adenomas we did not observe the association between gastrin levels and size, grade of dysplasia and histologic type of polyps.
  • [MeSH-major] Adenomatous Polyps / blood. Gastrins / blood

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  • (PMID = 19606697.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Gastrins
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25. Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels AB: Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology; 2008 Feb;134(2):388-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cigarette smoking and adenomatous polyps: a meta-analysis.
  • BACKGROUND & AIMS: Through the past 2 decades, a consistent association between cigarette smoking and colorectal adenomatous polyps, recognized precursor lesions of colorectal cancer, has been shown.
  • We performed a meta-analysis to provide a quantitative pooled risk estimate of the association, focusing on the different characteristics of the study populations, study designs, and clinical feature of the polyps.
  • CONCLUSIONS: This meta-analysis provides strong evidence of the detrimental effect of cigarette smoking on the development of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colorectal Neoplasms / epidemiology. Smoking / adverse effects


26. Summers RM, Liu J, Yao J, Brown L, Choi JR, Pickhardt PJ: Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps. AJR Am J Roentgenol; 2009 Nov;193(5):1305-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps.
  • OBJECTIVE: Hyperplastic polyps are more difficult to detect than adenomatous polyps at CT colonography (CTC), and it has been theorized that this difference in detectability is because hyperplastic polyps are flatter.
  • Using automated software that computes polyp height, we determined whether hyperplastic colonic polyps on CTC are indeed flatter than adenomatous polyps of comparable width.
  • One hundred eighty-five of the patients had at least one hyperplastic or adenomatous polyp 6-10 mm visible at both OC and CTC, where size was determined by a calibrated guidewire at OC.
  • To assess flatness, the heights of the polyps at CTC were measured using a validated automated software program.
  • The heights and height-to-width ratios of the hyperplastic polyps were compared with those of the adenomatous polyps using a Student's t test (two-tailed, unpaired, unequal variance).
  • RESULTS: There were 176 adenomatous and 83 hyperplastic polyps visible at segment-unblinded OC.
  • The fraction of these polyps that were measurable at CTC using the automated software was not significantly different for adenomatous versus hyperplastic polyps (158/176 [89.8%] vs 73/87 [83.9%], respectively; p = 0.2).
  • The average height-to-width ratios using automated width measurements were 15% less for hyperplastic polyps: 0.39 +/- 0.20 (n = 158) and 0.33 +/- 0.19 (n = 73) for adenomatous and hyperplastic polyps, respectively (p = 0.03).
  • When polyps of comparable OC size or CTC width were considered, the heights of hyperplastic polyps were up to 27% less than those of adenomatous polyps.
  • CONCLUSION: For 6-10 mm polyps of a given size as determined by OC or a given width at CTC, hyperplastic polyps tend to be flatter (i.e., have lower height) compared with adenomatous polyps.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic. Radiographic Image Interpretation, Computer-Assisted / methods
  • [MeSH-minor] Adenomatous Polyps / pathology. Adenomatous Polyps / radiography. Aged. Analysis of Variance. Automation. Colonoscopy. Contrast Media. Female. Humans. Hyperplasia. Male. Middle Aged. Retrospective Studies. Software

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  • [Cites] Abdom Imaging. 2002 May-Jun;27(3):292-300 [12173360.001]
  • [Cites] Acad Radiol. 2009 Jan;16(1):4-14 [19064206.001]
  • [Cites] N Engl J Med. 2003 Dec 4;349(23):2191-200 [14657426.001]
  • [Cites] Radiology. 2004 Sep;232(3):784-90 [15247435.001]
  • [Cites] AJR Am J Roentgenol. 2004 Nov;183(5):1343-7 [15505301.001]
  • [Cites] Gastroenterology. 1974 Mar;66(3):347-56 [4813500.001]
  • [Cites] Lancet. 1986 Feb 8;1(8476):307-10 [2868172.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Am J Gastroenterol. 1990 Dec;85(12):1557-9 [2252015.001]
  • [Cites] Gastrointest Endosc. 1991 Jan-Feb;37(1):88-91 [2004689.001]
  • [Cites] Gastrointest Endosc. 1994 Sep-Oct;40(5):588-91 [7988824.001]
  • [Cites] Gastroenterology. 1997 Jan;112(1):24-8 [8978338.001]
  • [Cites] Gastroenterol Clin North Am. 1997 Mar;26(1):85-101 [9119442.001]
  • [Cites] CA Cancer J Clin. 1997 Mar-Apr;47(2):93-112 [9074488.001]
  • [Cites] Radiology. 2005 Jul;236(1):3-9 [15987959.001]
  • [Cites] Am J Gastroenterol. 2006 Feb;101(2):343-50 [16454841.001]
  • [Cites] AJR Am J Roentgenol. 2006 Jun;186(6):1611-7 [16714650.001]
  • [Cites] Radiology. 2007 Jan;242(1):120-8 [17105850.001]
  • [Cites] AJR Am J Roentgenol. 2007 Apr;188(4):945-52 [17377028.001]
  • [Cites] Med Phys. 2007 May;34(5):1655-64 [17555247.001]
  • [Cites] Gastroenterol Clin North Am. 2007 Dec;36(4):947-68, viii [17996799.001]
  • [Cites] Acad Radiol. 2008 Feb;15(2):231-9 [18206622.001]
  • [Cites] JAMA. 2008 Mar 5;299(9):1027-35 [18319413.001]
  • [Cites] Endoscopy. 2008 Apr;40(4):284-90 [18389446.001]
  • [Cites] AJR Am J Roentgenol. 2008 May;190(5):1279-85 [18430844.001]
  • [Cites] N Engl J Med. 2008 Sep 18;359(12):1207-17 [18799557.001]
  • [Cites] Gastrointest Endosc. 2008 Oct;68(4 Suppl):S3-47 [18805238.001]
  • [Cites] AJR Am J Roentgenol. 2003 Sep;181(3):799-805 [12933484.001]
  • (PMID = 19843746.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-05; United States / Intramural NIH HHS / / Z01 CL040003-06; United States / Intramural NIH HHS / / ZIA CL040003-07; United States / Intramural NIH HHS / / ZIA CL040003-08; United States / Intramural NIH HHS / / ZIA CL040003-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ NIHMS394801; NLM/ PMC3412299
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27. Benes Z, Antos Z: Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy. Anticancer Res; 2009 Nov;29(11):4737-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy.
  • BACKGROUND: It has been established that the removal of adenomatous colon polyps drastically reduces the incidence of colorectal cancer (CRC), but polypectomy is not without risk.
  • The aim was to determine the correlation between the results of an optical biopsy system and the histopathology report of the physical biopsy specimens of the same polyps removed at colonoscopy.
  • PATIENTS AND METHODS: Paired optical and physical biopsies were performed on 55 polyps with complete polypectomy of the same tissue.
  • RESULTS: Fifty-three adenomatous polyps and two hyperplastic polyps were identified by the hospital pathologist.
  • The optical biopsy system identified 52 polyps as suspect (adenomatous) and 2 as non-suspect (hyperplastic).
  • One villous adenoma could not be optically analyzed due to friability.
  • CONCLUSION: The WavSTAT Optical Biopsy System provides accurate information to the gastroenterologist to assist in distinguishing between hyperplastic and adenomatous polyps.
  • It is safe for the patient and does not unduly increase the time required for an endoscopic examination.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colon / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy / methods. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonoscopy / methods. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Middle Aged. Optics and Photonics / methods. Prospective Studies

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  • (PMID = 20032428.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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28. Guo X, Zhang L, Wu M, Wang N, Liu Y, Er L, Wang S, Gao Y, Yu W, Xue H, Xu Z, Wang S: Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma. Mol Biol Rep; 2010 Jan;37(1):219-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.
  • The aim of this study is to investigate the correlation of the DNMT3B G39179T polymorphism with the susceptibilities of colorectal adenomatous polyps and adenocarcinoma.
  • This case-control study included 146 colorectal adenomatous polyps, 170 colorectal adenocarcinoma patients, and 157 normal controls.
  • Family history of colorectal cancer significantly increases the risk of developing colorectal adenomatous polyps and adenocarcinoma.
  • Compared with DNMT3B T/T genotype, the G allelotype (G/T + G/G genotype) had lower risk to develop colorectal adenocarcinoma (OR = 0.50, 95% CI = 0.29-0.87); while there was no significant difference between the colorectal adenomatous polyps patients and controls (OR = 0.63, 95% CI = 0.37-1.09), although descending tendency could be found in this polyps group.
  • Meanwhile, combined G/T + G/G genotypes were found to have a lower risk in non-drinkers to develop both colorectal adenomatous polyps and adenocarcinoma (OR = 0.54, 95% CI = 0.31-0.96 and OR = 0.48, 95% CI = 0.27-0.84, respectively).
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatous Polyps / genetics. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / genetics. DNA (Cytosine-5-)-Methyltransferase / genetics. Genetic Predisposition to Disease. Polymorphism, Single Nucleotide / genetics

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  • (PMID = 19626461.001).
  • [ISSN] 1573-4978
  • [Journal-full-title] Molecular biology reports
  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA methyltransferase 3B
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29. Jung WT, Li MS, Goel A, Boland CR: JC virus T-antigen expression in sporadic adenomatous polyps of the colon. Cancer; 2008 Mar 1;112(5):1028-36

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] JC virus T-antigen expression in sporadic adenomatous polyps of the colon.
  • The hypothesis that JCV DNA sequences and T-antigen (T-Ag) expression may be present in adenomatous polyps of the colon was tested.
  • METHODS: DNA was extracted from 74 paraffin-embedded adenomatous polyps.
  • RESULTS: JCV T-Ag sequences were found in 82% (61 of 74) of adenomas, and T-Ag protein was expressed in 16% (12 of 74) of these polyps.
  • The T-Ag staining was localized exclusively in the nuclei of adenoma cells, but never in the cytoplasm or the adjacent nonneoplastic cells.
  • The prevalence of MSI-H and non-MSI-H (MSI-L/MSS) in adenomatous polyps was 9.5% (7 of 74) and 90.5% (67 of 74), respectively.
  • Among the 61 adenomas that harbored JCV sequences, 8% (5 of 61) were MSI-H, and similarly among 12 adenomatous polyps expressing T-Ag protein 8% (1 of 12) of the adenomatous polyps were MSI-H.
  • CONCLUSIONS: JCV T-Ag DNA sequences are frequently present in adenomatous polyps of the colon, and T-Ag is expressed specifically in the nuclei of these premalignant lesions.

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  • [Cites] N Engl J Med. 2000 Jan 13;342(2):69-77 [10631274.001]
  • [Cites] Clin Cancer Res. 2005 Dec 1;11(23):8332-40 [16322293.001]
  • [Cites] Mol Cell Biol. 2000 Sep;20(17):6233-43 [10938100.001]
  • [Cites] Virology. 2000 Aug 15;274(1):165-78 [10936097.001]
  • [Cites] Int J Colorectal Dis. 2000 Aug;15(4):189-96 [11008717.001]
  • [Cites] Gastroenterology. 2000 Nov;119(5):1228-35 [11054380.001]
  • [Cites] J Virol. 2001 Feb;75(4):1996-2001 [11160700.001]
  • [Cites] Cancer Res. 2001 May 15;61(10):4287-93 [11358858.001]
  • [Cites] Oncogene. 2001 Aug 9;20(35):4864-70 [11521197.001]
  • [Cites] Am J Pathol. 2001 Dec;159(6):2107-16 [11733361.001]
  • [Cites] Gut. 2002 Mar;50(3):382-6 [11839719.001]
  • [Cites] J Natl Cancer Inst. 2002 Feb 20;94(4):267-73 [11854388.001]
  • [Cites] Gastroenterology. 2002 Dec;123(6):1804-11 [12454837.001]
  • [Cites] Cancer Res. 2002 Dec 1;62(23):7093-101 [12460931.001]
  • [Cites] J Neurovirol. 2002 Dec;8 Suppl 2:138-47 [12491166.001]
  • [Cites] J Gen Virol. 2003 Jun;84(Pt 6):1499-504 [12771419.001]
  • [Cites] Oncogene. 2003 Aug 11;22(33):5181-91 [12910255.001]
  • [Cites] Gastroenterology. 2004 Jan;126(1):42-8 [14699485.001]
  • [Cites] J Natl Cancer Inst. 2004 Feb 18;96(4):261-8 [14970275.001]
  • [Cites] Microbiol Immunol. 1982;26(11):1057-64 [6300615.001]
  • [Cites] J Virol. 1984 Aug;51(2):458-69 [6086957.001]
  • [Cites] J Virol. 1989 Feb;63(2):863-72 [2536108.001]
  • [Cites] J Virol. 1990 Mar;64(3):1353-6 [2154613.001]
  • [Cites] J Virol. 1992 Jul;66(7):3979-85 [1318392.001]
  • [Cites] Science. 1993 May 7;260(5109):812-6 [8484121.001]
  • [Cites] Science. 1993 May 7;260(5109):816-9 [8484122.001]
  • [Cites] Nature. 1993 Jun 10;363(6429):558-61 [8505985.001]
  • [Cites] Cancer Res. 1994 Apr 1;54(7):1645-8 [8137274.001]
  • [Cites] Int J Mol Med. 1998 Apr;1(4):647-55 [9852278.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7484-9 [10377441.001]
  • [Cites] J Gastroenterol Hepatol. 2005 Dec;20(12):1920-6 [16336454.001]
  • [Cites] Gut. 2006 May;55(5):695-702 [16354798.001]
  • [Cites] Gastroenterology. 2006 Jun;130(7):1950-61 [16762618.001]
  • [Cites] Cancer. 2006 Aug 1;107(3):481-8 [16795066.001]
  • [Cites] Gastroenterology. 2007 Jan;132(1):127-38 [17087942.001]
  • [Cites] J Neuropathol Exp Neurol. 2004 Nov;63(11):1124-30 [15581180.001]
  • [Cites] Cancer. 2005 Feb 1;103(3):516-27 [15630684.001]
  • [Cites] Dis Colon Rectum. 2005 Jan;48(1):86-91 [15690663.001]
  • [Cites] Am J Gastroenterol. 2005 May;100(5):1143-9 [15842591.001]
  • [Cites] Anticancer Res. 2005 Mar-Apr;25(2A):1079-85 [15868949.001]
  • [Cites] Gut. 2005 Sep;54(9):1321-31 [16099799.001]
  • [Cites] Virchows Arch. 2005 Oct;447(4):723-30 [16021515.001]
  • [Cites] Gut. 2000 Jul;47(1):37-42 [10861262.001]
  • (PMID = 18205186.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA098572-05; United States / NCI NIH HHS / CA / R01 CA098572; United States / NCI NIH HHS / CA / R01 CA 98572; United States / NCI NIH HHS / CA / R01 CA098572-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
  • [Other-IDs] NLM/ NIHMS187525; NLM/ PMC2855201
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30. Byun TJ, Han DS, Ahn SB, Cho HS, Eun CS, Jeon YC, Sohn JH, Oh YH: Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer. Gut Liver; 2009 Jun;3(2):130-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer.
  • Pseudoinvasion or pseudocarcinomatous invasion in an adenomatous polyp of the colon can be unfamiliar to an endoscopist.
  • Pseudoinvasion in an adenomatous polyp represents prolapse of the adenomatous epithelium into its stalk.
  • In most cases its morphology does not differ from of general adenomatous polyps, but in some cases it can morphologically mimic a malignant polyp with submucosal invasion due to mass-like lesioning of its stalk.
  • This makes it difficult for endoscopists to differentiate pseudoinvasion in an adenoma from an invasive carcinoma by conventional endoscopy; instead, endoscopic ultrasonography can provide useful information for differentiating these conditions.
  • We report on an 82-year-old man who presented with a large pedunculated polyp with a thick stalk in the sigmoid colon, which mimicked a submucosal invasive carcinoma.
  • The patient was diagnosed with pseudoinvasion in an adenomatous polyp after segmental resection of the sigmoid colon.

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  • [Cites] J Clin Pathol. 1973 Jan;26(1):25-31 [4540378.001]
  • [Cites] Cancer. 1974 Jan;33(1):206-17 [4810096.001]
  • [Cites] Dis Colon Rectum. 1980 Nov-Dec;23(8):529-35 [7460689.001]
  • [Cites] Endoscopy. 2001 Aug;33(8):709-18 [11490390.001]
  • [Cites] Adv Anat Pathol. 2008 Jan;15(1):1-17 [18156808.001]
  • [Cites] Gastrointest Endosc. 2003 May;57(6):722 [12709708.001]
  • [Cites] Pathol Int. 2003 Sep;53(9):584-90 [14507314.001]
  • [Cites] Gastrointest Endosc. 2005 Jan;61(1):1-7 [15672048.001]
  • [Cites] Am J Surg Pathol. 2002 Feb;26(2):206-15 [11812942.001]
  • (PMID = 20431736.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852693
  • [Keywords] NOTNLM ; Adenomatous polyps / EUS / Malignant polyp / Pseudoinvasion
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31. Mizuno S, Morita Y, Inui T, Asakawa A, Ueno N, Ando T, Kato H, Uchida M, Yoshikawa T, Inui A: Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy. Int J Cancer; 2005 Dec 20;117(6):1058-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Helicobacter pylori infection is associated with colon adenomatous polyps detected by high-resolution colonoscopy.
  • A significant increase in the incidence of adenomatous polyps (p < 0.0001) and decrease in normal colonoscopic findings (p < 0.0005) were observed in seropositive patients than those seronegative.
  • [MeSH-major] Adenomatous Polyps / microbiology. Colonic Neoplasms / microbiology. Colonic Polyps / microbiology. Colonoscopy. Helicobacter Infections. Helicobacter pylori

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • [CommentIn] Int J Cancer. 2006 Oct 15;119(8):1999-2000 [16708392.001]
  • (PMID = 15986436.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Immunoglobulin G
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32. Hwang ST, Cho YK, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Won KH, Jin W: Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. J Gastroenterol Hepatol; 2010 Mar;25(3):562-7
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  • [Title] Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps.
  • Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver.
  • This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.
  • We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361).
  • RESULTS: The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group.
  • By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60).
  • An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps.
  • CONCLUSION: NAFLD was associated with colorectal adenomatous polyps.
  • Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / complications. Fatty Liver / complications

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  • (PMID = 20074156.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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33. Ji BT, Weissfeld JL, Chow WH, Huang WY, Schoen RE, Hayes RB: Tobacco smoking and colorectal hyperplastic and adenomatous polyps. Cancer Epidemiol Biomarkers Prev; 2006 May;15(5):897-901
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tobacco smoking and colorectal hyperplastic and adenomatous polyps.
  • Colorectal adenomas and possibly some hyperplastic polyps are precursors of colorectal cancer.
  • Tobacco use is associated in epidemiologic studies with these polyps, although links between smoking and colorectal cancer are less consistent.
  • To characterize the role of tobacco in early colorectal carcinogenesis, we compared tobacco use among 4,383 subjects with histologically verified benign (hyperplastic or adenomatous) polyps of the distal colon (descending colon, sigmoid, and rectum) with tobacco use among 33,667 subjects who were endoscopy negative for distal colon tumors, in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Trial, a randomized trial of flexible sigmoidoscopy.
  • Risks, estimated by the odds ratio (OR), associated with current cigarette use were OR = 4.4 [95% confidence interval (95% CI), 3.7-5.2] for hyperplastic polyps only, OR = 1.8 (95% CI, 1.5-2.1) for adenomas only, and OR = 6.2 (95% CI, 4.7-8.3) for subjects with both hyperplastic and adenomatous polyps concurrently.
  • Effects were weaker among ex smokers; the smoking-associated ORs remained consistently higher for hyperplastic polyps.
  • Tobacco-associated risks for multiple polyps were also stronger when hyperplastic disease was involved.
  • In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions.
  • [MeSH-major] Adenomatous Polyposis Coli / etiology. Colorectal Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 16702367.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
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34. Steinhagen E, Markowitz AJ, Guillem JG: How to manage a patient with multiple adenomatous polyps. Surg Oncol Clin N Am; 2010 Oct;19(4):711-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How to manage a patient with multiple adenomatous polyps.
  • Adenomatous polyps are found on screening colonoscopy in 22.5% to 58.2% of the adult population and therefore represent a common problem.
  • Patients with multiple adenomatous polyps are of unique interest because a proportion of these patients have an inheritable form of colorectal cancer.
  • [MeSH-major] Adenomatous Polyposis Coli / therapy. Colorectal Neoplasms, Hereditary Nonpolyposis / therapy
  • [MeSH-minor] Adenomatous Polyps / genetics. Adenomatous Polyps / pathology. Adenomatous Polyps / therapy. Genetic Predisposition to Disease. Humans

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20883948.001).
  • [ISSN] 1558-5042
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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35. Ghelase F, Mogoş DS, Mărgăritescu D, Iordache S, Ghelase MS, Râmboiu S, Mogoş G, Bică M, Săftoiu A, Georgescu I: [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications]. Chirurgia (Bucur); 2009 Mar-Apr;104(2):159-65
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  • [Title] [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications].
  • AIM: To detect the patients with colorectal adenomatous polyps or those with adenocarcinoma areas with a view to prevent and to treat the malignant disease.
  • MATERIAL AND METHOD: A prospective study including 309 patients hospitalized between 2000-2005 diagnosed with isolated adenomatous polyps after repeated colonoscopies.
  • The research method was selective screening with identification of risk factors regarding the evolution of colorectal polyps in early cancer, using colonoscopy and histopathological examination.
  • RESULTS: We identified 464 single or multiple isolated polyps of which 399 were adenomas, 59 hyperplastic polyps and 6 other types of lesions.
  • Histologically we recorded 41 (13.27%) polyps with a low grade of dysplasia, 56 (18.12%) with severe dysplasia and 30 (9.7%) intramucosal adenocarcinoma with submucosal invasion.
  • TREATMENT: Colonoscopic polypectomy was used for benign polyps and in situ carcinoma.
  • CONCLUSIONS: High grade of dysplasia, the number of polyps, ulceration, bleeding, intraepithelial areas of neoplastic transformation are predictive factors for early colorectal cancer.
  • Depth of submucosal invasion of malignant transformed polyps are important pathological factors to predict lymphatic metastasis and to select the therapeutic procedure.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Colectomy / methods. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Cell Transformation, Neoplastic / pathology. Colonic Polyps / diagnosis. Colonic Polyps / surgery. Female. Humans. Male. Prospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 19499658.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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36. Dixon A, Wurm P, Hart A, Robinson R: Distal adenomatous polyps are rare in patients with inflammatory bowel disease. Postgrad Med J; 2006 Jan;82(963):76-8
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  • [Title] Distal adenomatous polyps are rare in patients with inflammatory bowel disease.
  • OBJECTIVE: There is an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD).
  • RESULTS: Of 106 patients (61 male, 45 female, mean age of 59 years), 80 suffered from ulcerative colitis, 20 from Crohn's disease, and six from indeterminate colitis.
  • CONCLUSIONS: The results suggest that distal adenomatous polyps are rare in patients aged 55-64 years with IBD compared with a control population.
  • This supports the hypothesis that lesions other than polyps are important for the development of colorectal cancer in patients with IBD.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / etiology. Inflammatory Bowel Diseases / etiology

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  • [Cites] Ann Surg. 1986 Feb;203(2):115-22 [3511864.001]
  • [Cites] Aliment Pharmacol Ther. 2004 Apr 15;19(8):879-87 [15080849.001]
  • [Cites] Gastroenterology. 1993 Dec;105(6):1716-23 [8253348.001]
  • [Cites] Gastroenterology. 1994 Jul;107(1):117-20 [7912678.001]
  • [Cites] Gastroenterology. 1994 Dec;107(6):1675-9 [7958678.001]
  • [Cites] Gut. 1995 Apr;36(4):590-8 [7737570.001]
  • [Cites] Eur J Gastroenterol Hepatol. 1996 Dec;8(12):1179-83 [8980937.001]
  • [Cites] Gut. 1998 Aug;43(2):229-31 [10189849.001]
  • [Cites] Clin Gastroenterol Hepatol. 2005 Jan;3(1):11-24 [15645399.001]
  • [Cites] Aliment Pharmacol Ther. 2000 Feb;14(2):145-53 [10651654.001]
  • [Cites] Inflamm Bowel Dis. 1999 Nov;5(4):304-5 [10579125.001]
  • [Cites] Inflamm Bowel Dis. 1999 Nov;5(4):306-8; discussion 309-10 [10579126.001]
  • [Cites] Gastroenterology. 1999 Dec;117(6):1288-94; discussion 1488-91 [10579969.001]
  • [Cites] Hepatogastroenterology. 2000 Jan-Feb;47(31):57-70 [10690586.001]
  • [Cites] Hum Pathol. 2000 Mar;31(3):288-91 [10746669.001]
  • [Cites] Gut. 2001 Apr;48(4):526-35 [11247898.001]
  • [Cites] Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:15-21 [12950416.001]
  • [Cites] N Engl J Med. 1987 Jun 25;316(26):1654-8 [3295551.001]
  • (PMID = 16397087.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 4Q81I59GXC / Mesalamine; MRK240IY2L / Azathioprine
  • [Other-IDs] NLM/ PMC2563726
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37. Smith GV, Feakins R, Farthing MJ, Ballinger A: Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. Am J Clin Pathol; 2005 Mar;123(3):415-20
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  • [Title] Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps.
  • Gastric adenomatous polyps are rare findings in upper gastrointestinal endoscopy; however, they are associated strongly with malignant transformation.
  • In the present study, we immunohisto-chemically assessed the expression of cyclooxygenase (COX)-2, beta-catenin, p53, and adenomatous polyposis coli (APC) in paraffin-embedded specimens of 14 gastric adenomas.
  • Similar alterations in oncoprotein expression were seen in gastric cancers but not in normal control sections.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Adenomatous Polyps / metabolism. Cytoskeletal Proteins / metabolism. Prostaglandin-Endoperoxide Synthases / metabolism. Stomach Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15716238.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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38. Gibson CJ, Parry NM, Jakowski RM, Cooper J: Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog. Vet Pathol; 2010 Jan;47(1):116-9
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  • [Title] Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog.
  • Endoscopically, the distal aspect of the esophagus was inflamed with a polypoid mass that protruded into the esophageal lumen.
  • This article reports a case of spontaneous esophageal adenomatous polyp with intestinal metaplasia (Barrett esophagus) and reviews the pathogenesis of esophageal metaplasia and adenocarcinoma.
  • [MeSH-major] Adenomatous Polyps / veterinary. Barrett Esophagus / veterinary. Dog Diseases / pathology. Esophageal Neoplasms / veterinary. Intestines / pathology

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  • (PMID = 20080491.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Ramadas A Jr, Kandiah M, Zarida H, Yunus Gul AG, Faizal JA: Obesity and risk of colorectal adenomatous polyps: a case-control study in hospital kuala lumpur. Malays J Nutr; 2009 Mar;15(1):1-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obesity and risk of colorectal adenomatous polyps: a case-control study in hospital kuala lumpur.
  • Several studies have proposed that obesity is a risk factor for colorectal adenoma.
  • This case-control study examined the relationship between body mass index (BMI), waist circumference, waistto-hip ratio (WHR), body fat percentage and colorectal adenomatous polyps (CRA) in patients who have had a colonoscopy at the Hospital Kuala Lumpur (HKL).
  • The mean BMI of female case subjects was significantly higher than control females (25.63 + 4.87 kg/m2 vs. 23.86 + 3.70 kg/m2, p<0.05) but the difference in BMI was not significant in men.

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  • (PMID = 22691799.001).
  • [ISSN] 1394-035X
  • [Journal-full-title] Malaysian journal of nutrition
  • [ISO-abbreviation] Malays J Nutr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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40. Kim BJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC, Choe YH, Choi YH, Shim SG, Kim YH: Coexistence between carotid artery stenosis and colorectal adenomatous polyps in middle-aged men. Digestion; 2010;81(1):20-6
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  • [Title] Coexistence between carotid artery stenosis and colorectal adenomatous polyps in middle-aged men.
  • BACKGROUND: Colorectal neoplasia and cardiovascular disease appear to share common risk factors.
  • RESULTS: The prevalence of overall colorectal adenomatous polyps (APs) was 31.4% (591/1,877).
  • [MeSH-major] Adenomatous Polyps / complications. Carotid Stenosis / complications. Colorectal Neoplasms / complications

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] Digestion. 2010;81(1):18-9 [20029205.001]
  • [CommentIn] Digestion. 2010;81(1):16-7 [20029204.001]
  • (PMID = 20051688.001).
  • [ISSN] 1421-9867
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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41. Schoen RE, Weissfeld JL, Kuller LH, Thaete FL, Evans RW, Hayes RB, Rosen CJ: Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology; 2005 Aug;129(2):464-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps.
  • We evaluated the relationship of insulin, IGF-I, insulin-like growth factor binding protein (IGFBP) 3, and visceral adipose tissue (VAT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer.
  • RESULTS: Four hundred fifty-eight subjects were enrolled, of which 202 subjects had an adenoma, 70 of which were an advanced adenoma.
  • In an unadjusted logistic regression analysis using sex-specific quartile cut points, subjects in quartile 4 in comparison with quartile 1 of IGF-I (odds ratio [OR] = 1.7; [95% CI: 1.0-2.9], Ptrend = .03), IGF-I/IGFBP-3 ratio (OR = 1.9 [95% CI: 1.1-3.3], Ptrend = .01), and insulin (OR = 2.1 [95% CI: 1.2-3.6], Ptrend = .04) were at increased risk of adenoma.
  • Visceral adipose tissue was not associated with adenoma risk.
  • These data support the hypothesis that insulin and IGF-I may contribute to the development and advancement of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology. Insulin / blood. Insulin-Like Growth Factor Binding Protein 1 / blood. Insulin-Like Growth Factor Binding Protein 3 / blood. Neoplasm Invasiveness / pathology

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  • (PMID = 16083703.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K07-CA72561
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin; 0 / Insulin-Like Growth Factor Binding Protein 1; 0 / Insulin-Like Growth Factor Binding Protein 3
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42. Siddiqui AA, Maddur H, Naik S, Cryer B: The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitus. Dig Dis Sci; 2008 Apr;53(4):1042-7
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  • [Title] The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitus.
  • The aim of our study was to determine whether poor control of diabetes mellitus (DM) is associated with increased prevalence of colonic adenomatous polyps (APs), especially those that are advanced .
  • Significant variables by UA were included in a stepwise logistic regression analysis to determine independent predictors of aggressive clinical behavior by the polyps.
  • All values are presented as means +/- SE, and statistical significance was determined at P < or = 0.05.
  • Logistic regression, as measured by HbA1c, demonstrated that poorly controlled DM-2 independently predicted a greater prevalence of right-sided AP, a more advanced lesion at the time of presentation, a greater number of polyps, and greater use of exogenous insulin.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology. Colonic Neoplasms / blood. Colonic Neoplasms / pathology. Diabetes Mellitus, Type 2 / blood. Hemoglobin A, Glycosylated / metabolism

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  • (PMID = 17939046.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Hemoglobin A, Glycosylated; 0 / hemoglobin A1c protein, human
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43. Parker-Ray N, Barakat J, Roy PK, White RE, Schrader RM, Hoffman RM: Statin use does not prevent recurrent adenomatous polyp formation in a VA population. Indian J Gastroenterol; 2010 Jun;29(3):106-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Statin use does not prevent recurrent adenomatous polyp formation in a VA population.
  • PURPOSE: To evaluate whether statin use was associated with recurrent adenomatous polyps.
  • During follow-up, 88 (47%) of patients received statins, but use was not protective against recurrent adenomas (hazard ratio = 1.36, 95% CI 0.35-8.27).
  • Only number of polyps at initial colonoscopy predicted recurrent adenomas (1.98, 95% CI 1.27-3.08).
  • CONCLUSIONS: The use of statins was not protective against the recurrence of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. Neoplasm Recurrence, Local / prevention & control. Veterans

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  • (PMID = 20658327.001).
  • [ISSN] 0975-0711
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors
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44. Rastogi A, Pondugula K, Bansal A, Wani S, Keighley J, Sugar J, Callahan P, Sharma P: Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology. Gastrointest Endosc; 2009 Mar;69(3 Pt 2):716-22
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  • [Title] Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology.
  • BACKGROUND: The 2 main types of colon polyps are adenomas and hyperplastic.
  • Pit patterns on the surface of polyps have been described by using magnification chromoendoscopy, which can help differentiate between polyp types.
  • Narrow band imaging (NBI) is a novel technology that enhances the visualization of surface mucosal and vascular patterns on the polyp surface.
  • Earlier we described, in a pilot study, patterns seen on the polyp surface with NBI that can help differentiate between adenomas and hyperplastic polyps with a high degree of accuracy.
  • OBJECTIVE: The aim of this study was to evaluate the interobserver and intraobserver agreement (among endoscopists) for the NBI surface mucosal and vascular patterns and prediction of polyp histology and the accuracy of the investigators to predict polyp histology based on these patterns.
  • METHODS: NBI images of the polyp surface mucosal and vascular patterns obtained in our pilot trial were retrieved.
  • A teaching set of 20 images was selected to educate and demonstrate the polyp patterns to 4 endoscopists.
  • Subsequently, the test set of images was evaluated by the 4 endoscopists for quality, polyp pattern, and prediction of polyp type.
  • Interobserver agreement (k value) was calculated among the 4 assessors for the polyp patterns and predicted histology.
  • By using the final histology as the criterion standard, the accuracy of polyp-type prediction was calculated for each assessor.
  • After a period of 2 months, all polyp images were reevaluated by the assessors (as before), and all findings were recorded in a similar fashion.
  • These results were used for calculation of intraobserver agreement (k value) and the accuracy of the assessors in predicting polyp type.
  • RESULTS: Photographs of 65 polyps were included in the test set and were evaluated by the 4 assessors.
  • Thirty-eight polyps were adenomatous, and 27 were hyperplastic.
  • The kappa value for the interobserver agreement for polyp surface pattern was 0.57 (moderate) and for prediction of polyp type was 0.63 (substantial).
  • The kappa value for the intraobserver agreement of the 4 assessors for the surface patterns was 0.70, 0.65, 0.60, and 0.79, and for the prediction of polyp type was 0.87, 0.71, 0.61, 0.81.
  • The accuracy to predict polyp type ranged from 80% to 86% for the 4 assessors in the first reading and from 85% to 91% in the second reading, with every assessor showing an improvement in accuracy in the second reading.
  • LIMITATIONS: A single-center study, with a limited number of polyps.
  • CONCLUSIONS: This initial evaluation showed that the NBI polyp patterns described in our pilot study are reproducible, easy to learn, reasonably accurate, and have the potential for use in daily clinical practice for the real-time differentiation of colon polyps.
  • [MeSH-major] Colonic Polyps / pathology. Colonoscopy / statistics & numerical data

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  • [CommentIn] Gastrointest Endosc. 2009 Mar;69(3 Pt 2):723-5 [19251017.001]
  • (PMID = 19251016.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Levin B, Lieberman DA, McFarland B, Andrews KS, Brooks D, Bond J, Dash C, Giardiello FM, Glick S, Johnson D, Johnson CD, Levin TR, Pickhardt PJ, Rex DK, Smith RA, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory Group, US Multi-Society Task Force, American College of Radiology Colon Cancer Committee: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology; 2008 May;134(5):1570-95
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  • [Title] Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
  • CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized.
  • In 2006 to 2007, the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults.
  • In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy.
  • When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that primarily is effective at early cancer detection and a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Colorectal Neoplasms / diagnosis. Mass Screening / standards. Population Surveillance / methods. Practice Guidelines as Topic. Societies, Medical


46. Arber N, Kuwada S, Leshno M, Sjodahl R, Hultcrantz R, Rex D, Exisulind Study Group: Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study. Gut; 2006 Mar;55(3):367-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study.
  • At baseline colonoscopy, left sided polyps (3-10 mm) were tattooed, measured, and left in place.
  • Follow up sigmoidoscopy was performed after six months, and removal of any remaining polyps at the 12 month colonoscopy.
  • The primary efficacy variable was change in polyp size from baseline.
  • The decrease in median polyp size was significantly greater (p=0.03) in patients who received exisulind 400 mg (-10 mm2) compared with those who received placebo (-4 mm2).
  • Complete or partial response was significantly higher in the exisulind 400 mg group (54.6%) compared with the placebo group (30.2%), and disease progression was significantly lower (6.1% v 27.9%) (p=0.04 and 0.02, respectively).
  • CONCLUSION: Exisulind caused significant regression of sporadic adenomatous polyps but was associated with more toxicity.
  • This model of polyp regression, short in its term and involving a comparatively small patient sample size, may be the best available tool to assess a therapeutic regimen before launching into large preventive clinical studies.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Antineoplastic Agents / therapeutic use. Sulindac / analogs & derivatives
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonoscopy. Combined Modality Therapy. Disease Progression. Dose-Response Relationship, Drug. Double-Blind Method. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • [Cites] N Engl J Med. 1993 Dec 30;329(27):1977-81 [8247072.001]
  • [Cites] Am J Gastroenterol. 1993 Oct;88(10):1652-6 [8213705.001]
  • [Cites] Gastroenterology. 1995 Apr;108(4):1083-7 [7698575.001]
  • [Cites] Gastroenterology. 1996 Feb;110(2):654-5 [8566622.001]
  • [Cites] Cancer Res. 1997 Jun 15;57(12):2452-9 [9192825.001]
  • [Cites] Am J Gastroenterol. 1997 Jul;92(7):1117-20 [9219781.001]
  • [Cites] Cancer Res. 1997 Jul 15;57(14):2909-15 [9230200.001]
  • [Cites] J Clin Invest. 1997 Sep 15;100(6):1325-9 [9294096.001]
  • [Cites] Eur J Surg Suppl. 1998;(582):111-4 [10029375.001]
  • [Cites] Scand J Gastroenterol. 1999 Jan;34(1):4-11 [10048725.001]
  • [Cites] N Engl J Med. 1999 Jun 17;340(24):1888-99 [10369853.001]
  • [Cites] Gut. 1997 Mar;40(3):344-9 [9135523.001]
  • [Cites] Clin Cancer Res. 2000 Jan;6(1):78-89 [10656435.001]
  • [Cites] Can J Gastroenterol. 2000 Apr;14(4):299-307 [10799083.001]
  • [Cites] Cancer Res. 2000 Jul 1;60(13):3338-42 [10910034.001]
  • [Cites] Gastroenterology. 2000 Sep;119(3):837-53 [10982778.001]
  • [Cites] Gastroenterology. 2000 Sep;119(3):854-65 [10982779.001]
  • [Cites] Med Clin North Am. 2000 Sep;84(5):1163-82, viii [11026923.001]
  • [Cites] Expert Opin Investig Drugs. 2001 Oct;10(10):1875-82 [11772293.001]
  • [Cites] J Clin Epidemiol. 2003 Oct;56(10):968-76 [14568628.001]
  • [Cites] Int J Cancer. 2004 Sep 10;111(4):633-9 [15239144.001]
  • [Cites] J Surg Oncol. 1983 Sep;24(1):83-7 [6887943.001]
  • [Cites] Gastroenterology. 1987 Nov;93(5):1009-13 [3653628.001]
  • [Cites] Am J Surg. 1989 Jan;157(1):175-9 [2535920.001]
  • [Cites] Bull World Health Organ. 1990;68(6):789-95 [2073716.001]
  • [Cites] Gastroenterology. 1991 Sep;101(3):635-9 [1650315.001]
  • [Cites] Ann Intern Med. 1991 Dec 15;115(12):952-4 [1659272.001]
  • [Cites] N Engl J Med. 1993 May 6;328(18):1313-6 [8385741.001]
  • [Cites] Ann Intern Med. 1993 Oct 15;119(8):836-43 [8379605.001]
  • [Cites] Adv Intern Med. 1994;39:123-47 [8140953.001]
  • (PMID = 16150858.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 184SNS8VUH / Sulindac; K619IIG2R9 / sulindac sulfone
  • [Other-IDs] NLM/ PMC1856089
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47. Bafandeh Y, Daghestani D, Esmaili H, Aharizad S: Distribution of cancer and adenomatous polyps in the colorectum: study in an Iranian population. Asian Pac J Cancer Prev; 2006 Jan-Mar;7(1):65-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distribution of cancer and adenomatous polyps in the colorectum: study in an Iranian population.
  • OBJECTIVE: There is consensus that the majority of colorectal carcinomas (CRCs) arise from adenomatous polyps.
  • If the same etiologic factors are operating for polyps and cancers their anatomical distributions should be the same.
  • MATERIALS AND METHODS: We reviewed, retrospectively , endoscopically reported anatomic sites of all adenomatous polyps and CRCs which were histologically confirmed from Jan 1992 to Dec 2005 in Tabriz, the North-west of Iran.
  • One hundred and forty-three CRC's and 180 adenomatous polyps (in 145 patients) were found.
  • Age and sex of patients, size and anatomic sites of polyps and cancers were studied.
  • In both cancer and adenoma cases the most common presenting symptoms were rectal bleeding and bloody diarrhea ( 52.4% , 16.9% and 39.2% , 15.8% for cancers and adenomas, respectively) without any significant difference(0>05).
  • The propensity for polyps to be found in the descending colon was of borderline significance (p=0.07).
  • The cecal segment uniquely demonstrated cancers(p=0.01) without any polyps.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenomatous Polyposis Coli / epidemiology. Adenomatous Polyposis Coli / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology

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  • (PMID = 16629518.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
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48. Castillo-Alcala F, Mans C, Bos AS, Taylor WM, Smith DA: Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo). Can Vet J; 2010 Nov;51(11):1261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo).
  • The histopathological diagnosis of the resected mass was an adenomatous polyp of the colon.
  • [MeSH-major] Adenomatous Polyps / veterinary. Colonic Polyps / veterinary. Ferrets

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  • [Cites] J Am Anim Hosp Assoc. 1997 Mar-Apr;33(2):156-60 [9111726.001]
  • [Cites] J Am Vet Med Assoc. 1998 May 1;212(9):1402-6 [9589126.001]
  • [Cites] Vet Surg. 2006 Jun;35(4):337-40 [16756613.001]
  • [Cites] N Engl J Med. 2006 Dec 14;355(24):2551-7 [17167138.001]
  • [Cites] BMJ. 2000 Oct 7;321(7265):886-9 [11021873.001]
  • (PMID = 21286327.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal = La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2957035
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49. Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, Dash C, Giardiello FM, Glick S, Levin TR, Pickhardt P, Rex DK, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory Group, US Multi-Society Task Force, American College of Radiology Colon Cancer Committee: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin; 2008 May-Jun;58(3):130-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
  • CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized.
  • In 2006 to 2007, the American Cancer Society, the US Multi Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults.
  • In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy.
  • When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps and a screening test that primarily is effective at early cancer detection.
  • [MeSH-major] Colonic Polyps / prevention & control. Colorectal Neoplasms / prevention & control. Mass Screening / standards


50. Tsai IC, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM: Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer; 2007 Mar 1;120(5):1005-12
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  • [Title] Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
  • We speculated that mutations in the autoinhibitory domain of CKIdelta/epsilon might upregulate CKIdelta/epsilon activity and hence Wnt signaling and increase the risk of adenomatous polyps and colon cancer.
  • Exons encoding the CKIepsilon and CKIdelta regulatory domains were sequenced from DNA obtained from individuals with adenomatous polyps and a family history of colon cancer unaffected by familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer (HNPCC).
  • A CKIdelta missense mutation, changing a highly conserved residue, Arg324, to His (R324H), was found in an individual with large and multiple polyps diagnosed at a relatively young age.
  • Although the R324H mutation does not significantly change CKIdelta kinase activity in an in vitro kinase assay or Wnt/beta-catenin signal transduction as assessed by a beta-catenin reporter assay, it alters morphogenetic movements via a beta-catenin-independent mechanism in early Xenopus development.
  • This novel human CKIdelta mutation may alter the physiological role and enhance the transforming ability of CKIdelta through a Wnt/beta-catenin independent mechanism and thereby influence colonic adenoma development.
  • [MeSH-major] Adenomatous Polyps / genetics. Casein Kinase Idelta / genetics. Colonic Neoplasms / genetics

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 17131344.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / PC / N01-PC-3541; United States / NCI NIH HHS / CA / P01 CA73992; United States / NCI NIH HHS / CA / P30 CA42014; United States / NCI NIH HHS / CA / R01 CA40641; United States / NCI NIH HHS / CA / R01 CA80809
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin; 4QD397987E / Histidine; 94ZLA3W45F / Arginine; EC 2.7.11.1 / Casein Kinase Idelta
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51. Niv Y, Vilkin A, Levi Z: Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study. J Clin Gastroenterol; 2010 Aug;44(7):489-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study.
  • We compared JCV antibody titers in patients with simple adenoma, advanced adenomatous polyp (AAP), CRC, and healthy controls, and evaluated JCV DNA in the tissue.
  • Normal colonoscopy, simple adenoma, AAP, and CRC were found in 41, 19, 12, and 25 cases, respectively.
  • The average titer for normal controls, simple polyp, AAP, and CRC was 2.61+/-0.72, 2.95+/-0.77, 3.33+/-0.76, and 3.30+/-0.50 log, respectively (P<0.001).
  • Viral DNA could not be shown in the serum.
  • The presence of neoplastic tissue T-Ag (in 33.3% of the patients) was not associated with a difference in the log titer of serum antibody.
  • If confirmed, our finding may serve as a marker for CRC or for an earlier stage of AAP.
  • [MeSH-major] Adenoma / virology. Adenomatous Polyps / virology. Colorectal Neoplasms / virology. JC Virus / immunology

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  • [CommentIn] J Clin Gastroenterol. 2010 Aug;44(7):466-8 [20520564.001]
  • (PMID = 20421810.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
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52. Fiducia G, Gandolfo L, Bosco V: [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases]. Chir Ital; 2008 Mar-Apr;60(2):227-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases].
  • [Transliterated title] Polipi adenomatosi rettoanali protrudenti isolati asportati per via transanale. Nostra esperienza.
  • Sixteen patients with low rectal or anal canal neoplastic polyps underwent transanal resection.
  • [MeSH-major] Intestinal Polyps / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18689170.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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53. Stelzner F: [Autoregulatory growth control of adenomatous polyps and carcinogenesis in the colorectal region. Basics of tumor surgery Part I]. Chirurg; 2006 Nov;77(11):1048-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Autoregulatory growth control of adenomatous polyps and carcinogenesis in the colorectal region. Basics of tumor surgery Part I].
  • Autoregulatory growth control of adenomatous polyps in the colon and rectum is an important factor in the success of sphincter-sparing surgical resections.
  • Similar to normal mucosa, adenomatous polyps in the colorectum show autoregulatory growth control in their tissues.
  • However, convincing evidence on a molecular level that this so-called adenoma-carcinoma sequence indeed occurs in vivo is lacking.
  • [MeSH-major] Adenomatous Polyps / pathology. Cell Division / physiology. Colonic Polyps / pathology. Colonic Polyps / surgery. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Homeostasis / physiology
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Bone Marrow Cells / pathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Chromosome Aberrations. Colon / pathology. Colon / surgery. Gene Expression Regulation, Neoplastic / physiology. Humans. Neoplasm Staging. Prognosis. Rectum / pathology. Rectum / surgery

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  • [CommentIn] Chirurg. 2006 Nov;77(11):1061-2 [17066270.001]
  • (PMID = 17068665.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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54. Tony J, Harish K, Ramachandran TM, Sunilkumar K, Thomas V: Profile of colonic polyps in a southern Indian population. Indian J Gastroenterol; 2007 May-Jun;26(3):127-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Profile of colonic polyps in a southern Indian population.
  • BACKGROUND: In Western countries, colonic polyps are usually adenomatous in nature, are evenly distributed along the entire colon in asymptomatic per-sons and show a left-sided predominance in symptomatic patients.
  • Clinical features, colonoscopic description and histologic findings of all patients with polyps were noted.
  • Association of the degree of dysplasia with the size, site and type of polyps and the person's age was assessed.
  • RESULTS: Polyps were seen in 124 (5.1%) of 2412 complete colonoscopies.
  • Mean age of patients with polyps was 58.1 (SD 19.9) years; ninety were men.
  • A majority of polyps (92%) were located in the left colon.
  • They were adenomatous in 99 (79.8%), juvenile in 12 (9.8%), hyperplastic in 11 (8.8 %), inflammatory in 1 (0.8%) and Peutz-Jegher's polyp in 1 (0.8%).
  • Dysplasia was severe in large (>2 cm) polyps compared to small (< 1 cm) ones (p< 0.001).
  • Age of patient and location of polyp had no association with degree of dysplasia.
  • CONCLUSIONS: In southern Indian adults, most colonic polyps are adenomatous and are in the left colon.
  • Large polyps are associated with severe dysplasia.
  • [MeSH-major] Colonic Polyps / epidemiology

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  • (PMID = 17704579.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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55. Cardoso J, Molenaar L, de Menezes RX, van Leerdam M, Rosenberg C, Möslein G, Sampson J, Morreau H, Boer JM, Fodde R: Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cancer Res; 2006 Mar 01;66(5):2514-9
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  • [Title] Chromosomal instability in MYH- and APC-mutant adenomatous polyps.
  • Recently, biallelic germ line mutations in the MYH gene were found to be responsible for MYH-associated polyposis (MAP), an autosomal recessive predisposition to multiple colorectal polyps, often indistinguishable from the dominant familial adenomatous polyposis (FAP) syndrome caused by inherited APC mutations.
  • Here, we analyzed MYH- and APC-mutant polyps by combining laser capture microdissection, isothermal genomic DNA amplification, and array comparative genomic hybridization.
  • Up to 80% and 60% of the MAP and FAP polyps showed aneuploid changes, respectively.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Aneuploidy. Chromosomal Instability. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Genes, APC. Germ-Line Mutation

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  • (PMID = 16510566.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0301154
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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56. McLean MH, Murray GI, Fyfe N, Hold GL, Mowat NA, El-Omar EM: COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. Histopathology; 2008 Jun;52(7):806-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics.
  • AIMS: To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation.
  • The number of adenoma specimens was then extended to include polyps exhibiting an increasing degree of epithelial dysplasia.
  • Forty colonic hyperplastic polyps were also identified from the pathology diagnostic database and included in the analysis.
  • There was a statistically significant increase in COX-2 expression in colonic polyps compared with paired adjacent normal mucosa, chi(2) = 40.1, P = 0.001.
  • The probability of COX-2 expression increased along with increasing adenoma size and increasing degree of epithelial dysplasia.
  • Fifty-five per cent of the hyperplastic polyp specimens expressed COX-2.
  • CONCLUSIONS: This study associates COX-2 epithelial expression with a number of adenoma characteristics that convey an increased risk of malignant transformation.
  • [MeSH-major] Adenomatous Polyps / enzymology. Colonic Polyps / enzymology. Colorectal Neoplasms / enzymology. Cyclooxygenase 2 / metabolism. Intestinal Mucosa / enzymology

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  • (PMID = 18462368.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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57. Mai PL, Korde L, Kramer J, Peters J, Mueller CM, Pfeiffer S, Stratakis CA, Pinto PA, Bratslavsky G, Merino M, Choyke P, Linehan WM, Greene MH: A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. J Med Case Rep; 2007 Mar 28;1:9
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  • [Title] A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report.
  • BACKGROUND: Germ-cell testicular cancer has not been definitively linked to any known hereditary cancer susceptibility disorder.
  • His evaluation as part of an etiologic study of familial testicular cancer revealed multiple colon polyps (adenomatous, hyperplastic, and hamartomatous) first found in his 50 s, multiple lipomas, multiple hyperpigmented skin lesions, left kidney cancer diagnosed at age 64, and a growth-hormone producing pituitary adenoma with associated acromegaly diagnosed at age 64.
  • DISCUSSION: The constellation of benign and malignant neoplasms in the context of this patient's familial testicular cancer raised the possibility that these might be manifestations of a known hereditary susceptibility cancer syndrome; however, genetic testing for the three syndromes that were most likely to explain these findings did not show any mutation.

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  • [Cites] Br J Neurosurg. 2004 Dec;18(6):629-31 [15799199.001]
  • [Cites] Horm Res. 2004;62 Suppl 1:108-15 [15761242.001]
  • [Cites] Am J Gastroenterol. 2005 Feb;100(2):476-90 [15667510.001]
  • [Cites] Dig Dis Sci. 2004 Apr;49(4):662-6 [15185875.001]
  • [Cites] Lancet Oncol. 2004 Jun;5(6):363-71 [15172357.001]
  • [Cites] Cancer. 2003 Feb 15;97(4):984-92 [12569597.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Dec;86(12):5658-71 [11739416.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Sep;86(9):4041-6 [11549623.001]
  • [Cites] J Neurosurg. 2000 Mar;92(3):413-8 [10701527.001]
  • [Cites] J Natl Cancer Inst. 2005 Sep 21;97(18):1354-65 [16174857.001]
  • [Cites] Science. 2006 May 26;312(5777):1228-30 [16728643.001]
  • [Cites] Hum Mol Genet. 2006 Feb 1;15(3):443-51 [16407372.001]
  • (PMID = 17411461.001).
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CP / N02CP11019
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1847830
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58. Bouraoui S, Azouz H, Kechrid H, Lemaiem F, Mzabi-Regaya S: [Peutz-Jeghers' syndrome with malignant development in a hamartomatous polyp: report of one case and review of the literature]. Gastroenterol Clin Biol; 2008 Mar;32(3):250-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Peutz-Jeghers' syndrome with malignant development in a hamartomatous polyp: report of one case and review of the literature].
  • [Transliterated title] Dégénérescence inaugurale d'un polype hamartomateux au cours du syndrome de Peutz-Jeghers: à propos d'un cas avec revue de la littérature.
  • The malignant potential of hamartomatous polyps in Peutz-Jeghers' (PPJ) syndrome has been debated.
  • Although it is a very rare event, these polyps can become malignant, as demonstrated by this report.
  • The patient had colonic carcinoma which developed in a hamartomatous polyp.
  • The malignant development of this colonic hamartomatous polyp arising in Peutz-Jeghers' syndrome was pathologically confirmed at surgery.
  • This case also shows a sequence of hamartoma-dysplasia-carcinoma in a hamartomatous polyp without adenomatous changes.
  • This suggests that hamartomatous polyps in Peutz-Jeghers' syndrome may develop into adenocarcinoma and may be a precursor of gastrointestinal carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Cell Transformation, Neoplastic / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Hamartoma / pathology. Peutz-Jeghers Syndrome / complications

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  • (PMID = 18456106.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 32
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59. Kim MS, Jung HK, Jung HS, Choi JY, Na YJ, Pyun GW, Ryu JH, Moon IH, Jo MS: [A Case of Cronkhite-Canada syndrome showing resolution with Helicobacter pylori eradication and omeprazole]. Korean J Gastroenterol; 2006 Jan;47(1):59-64
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  • Histology of polyps from the stomach showed features of juvenile or retention type (hamartomatous) polyps with Helicobacter pylori (H. pylori) infection.
  • The large pedunculated colonic polyps showed hamartomatous polyps with adenomatous component and polypectomy was performed.
  • After the treatment with H. pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed.
  • [MeSH-major] Anti-Ulcer Agents / therapeutic use. Helicobacter Infections / drug therapy. Helicobacter pylori. Omeprazole / therapeutic use. Polyps / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Colonic Polyps / complications. Colonic Polyps / microbiology. Colonic Polyps / pathology. Female. Humans. Hyperpigmentation / pathology. Middle Aged. Nails, Malformed / pathology. Proton Pump Inhibitors. Syndrome

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  • (PMID = 16434870.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents; 0 / Proton Pump Inhibitors; KG60484QX9 / Omeprazole
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60. Sato Y, Nozaki R, Yamada K, Takano M, Haruma K: Relation between obesity and adenomatous polyps of the large bowel. Dig Endosc; 2009 Jul;21(3):154-7
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  • [Title] Relation between obesity and adenomatous polyps of the large bowel.
  • BACKGROUND: We compared the prevalence of colorectal adenoma (polyps) in men and women and examined the role of body mass index (BMI) on polyp risk according to patient age and gender.
  • METHODS: The risk of developing colorectal polyps was studied in 15 380 subjects (7155 men and 8225 women) who underwent colonoscopy for the first time from April 1998 to March 2006 at our 'Human Dry Dock', which is the check-up service provided in Japan.
  • Eligible subjects were 20-86 years old (mean age +/- SD, 47.3 +/- 8.5) and were free of invasive cancer, hyperplastic polyps and familial polyposis.
  • Polyps were found in 1590 subjects (1062 men and 528 women).
  • The odds ratio (OR) of detection of polyps in relation to obesity was determined in all cases by multivariate logistic regression analysis after making an adjustment for gender and age.
  • RESULTS: The OR of polyp detection in obese subjects (BMI >or= 25) versus non-obese subjects (BMI < 25, OR = 1) was 1.34 (P < 0.001) in men and 1.13 (P = 0.26) in women.
  • CONCLUSIONS: We conclude that obesity in men is a risk factor for the development of polyps.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology

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  • (PMID = 19691761.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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61. Su YH, Wang M, Brenner DE, Norton PA, Block TM: Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. Ann N Y Acad Sci; 2008 Aug;1137:197-206
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  • [Title] Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.

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  • [Cites] Clin Cancer Res. 2001 Sep;7(9):2727-30 [11555585.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:40-3 [15251937.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:81-9 [15251944.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:271-81 [15251972.001]
  • [Cites] Oncol Res. 2004;14(9):439-45 [15490975.001]
  • [Cites] J Clin Invest. 1973 Jan;52(1):198-204 [4629907.001]
  • [Cites] Cancer Res. 1977 Mar;37(3):646-50 [837366.001]
  • [Cites] Arthritis Rheum. 1982 Dec;25(12):1425-30 [6128984.001]
  • [Cites] Cancer. 1983 Jun 1;51(11):2116-20 [6188527.001]
  • [Cites] J Virol Methods. 1984 Feb;8(1-2):73-86 [6323510.001]
  • [Cites] J Clin Invest. 1984 Mar;73(3):832-41 [6323528.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Pathol Int. 1995 Oct;45(10):721-8 [8563932.001]
  • [Cites] Toxicol Lett. 1995 Dec;82-83:143-8 [8597042.001]
  • [Cites] Nat Med. 1996 Sep;2(9):1033-5 [8782463.001]
  • [Cites] Nat Med. 1996 Sep;2(9):1035-7 [8782464.001]
  • [Cites] Cancer Res. 2001 Feb 15;61(4):1659-65 [11245480.001]
  • [Cites] Clin Chem. 2006 Oct;52(10):1833-42 [16423903.001]
  • [Cites] Gut. 1999 Nov;45(5):686-92 [10517904.001]
  • [Cites] Cancer Metastasis Rev. 1999;18(1):65-73 [10505546.001]
  • [Cites] Mod Pathol. 1999 Jun;12(6):604-11 [10392637.001]
  • [Cites] Cancer Res. 1999 Jan 1;59(1):71-3 [9892188.001]
  • [Cites] Cancer Res. 1999 Jan 1;59(1):67-70 [9892187.001]
  • [Cites] Cancer Res. 1998 Oct 15;58(20):4728-32 [9788629.001]
  • [Cites] Lancet. 1997 Aug 16;350(9076):485-7 [9274585.001]
  • [Cites] Gastroenterology. 2000 Nov;119(5):1219-27 [11054379.001]
  • [Cites] Cancer Genet Cytogenet. 2000 Aug;121(1):73-7 [10958945.001]
  • [Cites] Clin Chem. 2000 Aug;46(8 Pt 1):1078-84 [10926886.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:1-8 [15251932.001]
  • [Cites] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3972-9 [15217927.001]
  • [Cites] J Mol Diagn. 2004 May;6(2):101-7 [15096565.001]
  • [Cites] Clin Cancer Res. 2004 Mar 15;10(6):1887-93 [15041703.001]
  • [Cites] Clin Chem. 2004 Jan;50(1):211-3 [14709652.001]
  • [Cites] Cancer Res. 2003 Sep 15;63(18):5723-6 [14522891.001]
  • [Cites] Cancer Res. 2003 May 1;63(9):2028-32 [12727814.001]
  • [Cites] Ann Clin Biochem. 2003 Mar;40(Pt 2):122-30 [12662399.001]
  • [Cites] Clin Cancer Res. 2002 Oct;8(10):3156-63 [12374683.001]
  • [Cites] Clin Cancer Res. 2002 Jan;8(1):35-40 [11801538.001]
  • [Cites] Gut. 1997 May;40(5):660-3 [9203947.001]
  • [Cites] Gastroenterology. 2001 Sep;121(3):599-611 [11522744.001]
  • [Cites] Gastroenterology. 2001 Aug;121(2):302-9 [11487539.001]
  • [Cites] Bull Exp Biol Med. 2001 Mar;131(3):283-4 [11427923.001]
  • [Cites] Ann N Y Acad Sci. 2004 Jun;1022:17-24 [15251934.001]
  • (PMID = 18837947.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA125642-01A2; United States / NCI NIH HHS / CA / CA86400; United States / NCI NIH HHS / CA / R01 CA125642; United States / NCI NIH HHS / CA / U01 CA086400; United States / NCI NIH HHS / CA / CA125642-01A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 9007-49-2 / DNA; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ NIHMS72455; NLM/ PMC2587049
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62. Benfatto G, Tenaglia L, Catania G, D'Antoni S, Jiryis A, Centoze D, Garufi SM, Mugavero F, Giovinetto A: Pathological evaluation in colorectal polyps endoscopic treatment. G Chir; 2006 Nov-Dec;27(11-12):411-6
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  • [Title] Pathological evaluation in colorectal polyps endoscopic treatment.
  • This retrospective study shows that endoscopic polypectomy is the technique of choice to remove the majority of polyps; follow-up and pathologic examinations shed light on the carcinogenesis of colorectal lesions.
  • From January 1990 to December 2001, 1302 adenomatous polyps were removed, 1175 endoscopically, 127 with surgical procedures.
  • The anatomical and morphologic conditions of the colon and some characteristics of the polyps represent limits to the feasibility and to the efficacy of polypectomy, and the most important variables for the correct management of the patients affected by colorectal adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Adenomatous Polyposis Coli / surgery. Endoscopy

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  • (PMID = 17198549.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
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63. Cappell MS: The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps. Med Clin North Am; 2005 Jan;89(1):1-42, vii
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  • [Title] The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps.
  • A review of the pathophysiology, clinical presentation, and diagnosis of colon cancer and colonic polyps is important and timely.
  • This article reviews colon cancer and colonic polyps, with a focus on recent dramatic advances, to help the pri-mary care physician and internist appropriately refer patients for screening colonoscopy and intelligently evaluate colonoscopic findings to reduce the mortality from this cancer.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / physiopathology. Colonic Neoplasms / diagnosis. Colonic Neoplasms / physiopathology

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  • (PMID = 15527807.001).
  • [ISSN] 0025-7125
  • [Journal-full-title] The Medical clinics of North America
  • [ISO-abbreviation] Med. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 251
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64. Gryfe R: Overview of colorectal cancer genetics. Surg Oncol Clin N Am; 2009 Oct;18(4):573-83
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  • Cancer is a genetic disease in which the clonal accumulation of genetic alterations confers a cell with the malignant characteristics of uncontrolled growth, local invasiveness, and metastastic potential.
  • Studies of colorectal cancer and its precursor lesion, the adenomatous polyp, have served as the cornerstone in advancing knowledge of cancer molecular genetics.

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  • (PMID = 19793566.001).
  • [ISSN] 1558-5042
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Number-of-references] 81
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65. Fearnhead NS, Winney B, Bodmer WF: Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model. Cell Cycle; 2005 Apr;4(4):521-5
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  • Each variant confers a moderate, but detectable, increase in relative risk of developing the disease.
  • Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Genetic Predisposition to Disease
  • [MeSH-minor] Adenomatous Polyps / pathology. Base Pair Mismatch. DNA Repair. Disease Susceptibility. Genetic Variation. Humans. Intestinal Polyps. Multifactorial Inheritance. Risk. Wnt Proteins / metabolism

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  • (PMID = 15753653.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins
  • [Number-of-references] 62
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66. Morais DJ, Yamanaka A, Zeitune JM, Andreollo NA: Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies. Arq Gastroenterol; 2007 Jan-Mar;44(1):14-7
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  • [Title] Gastric polyps: a retrospective analysis of 26,000 digestive endoscopies.
  • BACKGROUND: Gastric polyps are small gastric lesions, asymptomatic in most cases and are generally discovered inadvertently during upper digestive endoscopy.
  • AIM: To retrospectively review the characteristics and frequency of gastric polyps, derived from the gastric mucosal epithelium in a large series of endoscopies.
  • All patients had at least one gastric polyp, as confirmed by histological examination.
  • RESULTS: The polyps were classified as hyperplastic, adenomatous and fundic gland polyps.
  • The most of them measure less than 1 cm (hyperplastic polyps - 60,5%; adenomatous polyps - 73,6%; fundic gland polyps - 72%).
  • Hyperplastic polyps were the most frequent and accounted for 71.3% of the cases, whereas fundic gland polyps accounted for 16.3% and adenomatous polyps for 12.4%.
  • Hyperplastic and adenomatous polyps were primarily single, whereas fundic gland polyps tended to be multiple.
  • A carcinoma was detected in one hyperplastic polyp (0.9%) and in two adenomatous polyps (10.5%).
  • High grade dysplastic foci were found in four adenomatous polyps (21%).
  • CONCLUSIONS: The digestive endoscopy is the safest and efficient method for the diagnosis of the gastric polyps, that in most of the patients does not show characteristic symptoms.
  • The histopathological definition is not possible to the endoscopic glance being needed the pathologist's aid, once the conduct to be adopted will depend on the result of the biopsy.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Adult. Aged. Aged, 80 and over. Female. Gastric Fundus. Gastroscopy. Humans. Hyperplasia / pathology. Hyperplasia / surgery. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Stomach Neoplasms / diagnosis. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 17639176.001).
  • [ISSN] 0004-2803
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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67. Weizman AV, Nguyen GC: Colon cancer screening in 2010: an up-date. Minerva Gastroenterol Dietol; 2010 Jun;56(2):181-8
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  • The prognosis for limited disease is excellent; however, it becomes poor for more advanced disease.
  • The majority of colorectal cancers arise from premalignant adenomatous polyps.
  • This makes the detection of polyps and early carcinoma an attractive screening strategy.
  • [MeSH-minor] Adenomatous Polyps / complications. Guaiac. Humans. Indicators and Reagents. Occult Blood. Practice Guidelines as Topic. Predictive Value of Tests. Prognosis. Risk Factors. Sensitivity and Specificity

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  • (PMID = 20485255.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Indicators and Reagents; 9000-29-7 / Guaiac
  • [Number-of-references] 62
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68. Frazzetta M, Raimondo D, Furgiuele G, Sammartano A, Romito F, Frazzetta F, Lucania M, Piccolo CL, Bonventre S: Gastric polypoid lesions. Our experience. G Chir; 2010 Apr;31(4):162-6
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  • [Title] Gastric polypoid lesions. Our experience.
  • PATIENTS AND METHODS: A study on 2000 OGD (oesophagogastroduodenoscopy) has been carried out on 95 patients with polypoid lesions.
  • RESULTS: In the majority of the cases, the polypoid lesions were asymptomatic, the localization changed according to the histological type, with the antrum as the most affected area.
  • The presence of Helicobacter pylori does not seem to be correlated to the lesion, except in the case of hyperplastic polyps.
  • The percentage of risks of cancerization increased in case of adenomatous polyps.
  • In one patient signet ring cell carcinoma within a gastric polyp was found.
  • Gastric signet ring cell carcinomas are peculiar for their rarity as well as for the growth in polypoid lesions.
  • CONCLUSION: We confirm the higher frequency of hyperplastic polyps and the correlation between histological type and localization.
  • Endoscopic polipectomy is the first approach in gastric polyps, with lower risk of developing cancer.
  • [MeSH-major] Polyps / surgery. Stomach Diseases / surgery

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  • (PMID = 20444334.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
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69. Pino MS, Mino-Kenudson M, Wildemore BM, Ganguly A, Batten J, Sperduti I, Iafrate AJ, Chung DC: Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. J Mol Diagn; 2009 May;11(3):238-47
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  • The combination of MSI and IHC testing in colorectal adenomas is a sensitive screen for the detection of Lynch syndrome and may be particularly useful when Lynch syndrome is suspected and adenomatous polyps are the only tissues available for analysis.

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  • [Cites] Gastroenterology. 2004 Jan;126(1):42-8 [14699485.001]
  • [Cites] Fam Cancer. 2001;1(2):87-92 [14574003.001]
  • [Cites] Cancer. 1971 Jun;27(6):1505-11 [5088221.001]
  • [Cites] Cancer. 1991 Sep 1;68(5):1109-12 [1913482.001]
  • [Cites] Science. 1993 May 7;260(5109):816-9 [8484122.001]
  • [Cites] Nature. 1993 Jun 10;363(6429):558-61 [8505985.001]
  • [Cites] Cell. 1993 Dec 3;75(5):1027-38 [8252616.001]
  • [Cites] Science. 1994 Mar 18;263(5153):1625-9 [8128251.001]
  • [Cites] Nature. 1994 Mar 17;368(6468):258-61 [8145827.001]
  • [Cites] Nature. 1994 Sep 1;371(6492):75-80 [8072530.001]
  • [Cites] Cancer Res. 1994 Nov 1;54(21):5523-6 [7923189.001]
  • [Cites] Mutat Res. 1994 Oct 1;310(1):125-33 [7523876.001]
  • [Cites] Gastroenterology. 1996 Aug;111(2):307-17 [8690195.001]
  • [Cites] Cancer Res. 1996 Nov 1;56(21):4836-40 [8895729.001]
  • [Cites] Pathology. 1997 Feb;29(1):28-33 [9094174.001]
  • [Cites] Gut. 1997 May;40(5):660-3 [9203947.001]
  • [Cites] Gastroenterology. 1997 Oct;113(4):1146-58 [9322509.001]
  • [Cites] Nat Genet. 1997 Nov;17(3):271-2 [9354786.001]
  • [Cites] Am J Pathol. 1998 Oct;153(4):1063-78 [9777938.001]
  • [Cites] Cancer Res. 1998 Nov 15;58(22):5248-57 [9823339.001]
  • [Cites] Gut. 1999 Jun;44(6):839-43 [10323887.001]
  • [Cites] J Clin Pathol. 1999 Jan;52(1):5-9 [10343605.001]
  • [Cites] Am J Surg Pathol. 2005 Jan;29(1):96-104 [15613860.001]
  • [Cites] J Mol Diagn. 2005 May;7(2):160-70 [15858139.001]
  • [Cites] Mod Pathol. 2005 Aug;18(8):1095-101 [15731775.001]
  • [Cites] Int J Colorectal Dis. 2006 Oct;21(7):632-41 [16511680.001]
  • [Cites] JAMA. 2006 Sep 27;296(12):1507-17 [17003399.001]
  • [Cites] J Clin Oncol. 2008 Jul 10;26(20):3434-9 [18612159.001]
  • [Cites] J Med Genet. 1999 Nov;36(11):801-18 [10544223.001]
  • [Cites] J Clin Pathol. 1999 Jun;52(6):455-60 [10562815.001]
  • [Cites] Am J Pathol. 1999 Dec;155(6):1849-53 [10595914.001]
  • [Cites] Annu Rev Genet. 1999;33:533-64 [10690417.001]
  • [Cites] Curr Opin Genet Dev. 2000 Apr;10(2):157-61 [10753784.001]
  • [Cites] Gastroenterology. 2000 May;118(5):829-34 [10784581.001]
  • [Cites] Gut. 2000 Jul;47(1):37-42 [10861262.001]
  • [Cites] Gut. 2000 Aug;47(2):315-6 [10960281.001]
  • [Cites] Hum Mol Genet. 2001 Apr;10(7):735-40 [11257106.001]
  • [Cites] Lab Invest. 2001 Apr;81(4):535-41 [11304573.001]
  • [Cites] Cancer Res. 2001 Jun 1;61(11):4545-9 [11389088.001]
  • [Cites] Am J Hum Genet. 2002 Jan;70(1):26-37 [11709755.001]
  • [Cites] Gut. 2002 Feb;50(2):228-34 [11788565.001]
  • [Cites] Gut. 2002 Mar;50(3):382-6 [11839719.001]
  • [Cites] Cancer Res. 2002 Jun 15;62(12):3485-92 [12067992.001]
  • [Cites] Mod Pathol. 2002 Jul;15(7):741-9 [12118112.001]
  • [Cites] Gastroenterology. 2003 Aug;125(2):501-9 [12891553.001]
  • [Cites] Cancer Res. 2003 Aug 15;63(16):4878-81 [12941809.001]
  • [Cites] Am J Gastroenterol. 2003 Oct;98(10):2306-11 [14572584.001]
  • [Cites] Clin Cancer Res. 2004 May 1;10(9):3082-90 [15131047.001]
  • (PMID = 19324997.001).
  • [ISSN] 1943-7811
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA092594; United States / NCI NIH HHS / CA / CA92594
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2671341
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70. Ma YM, Wu BP, Xia OD: [Expression and significance of interferon-inducible transmembrane protein-1 gene in Peutz-Jeghers syndrome]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Mar;29(3):541-3
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  • OBJECTIVE: To detect the mRNA and protein expression of interferon-inducible transmembrane protein-1 (IFITM1) in Peutz-Jeghers syndrome (PJS) and investigate the role of IFITM1 in the occurrence, development and carcinogenesis of PJS polyps.
  • METHODS: Reverse transcription-PCR was employed to detect the mRNA expression of IFITM1 in 16 PJS polyp samples, adenomatous polyp tissues, colon adenocarcinoma samples, and normal intestinal mucosal tissues.
  • RESULTS: The IFITM1 mRNA expression was detected in all these tissues, and the expression intensity increased in the order of normal intestinal mucosa, PJS polyp, adenomatous polyp, and colon adenocarcinoma (F=92.704, P=0.000).
  • CONCLUSION: The expression level of IFITM1 is associated with the progression of the carcinogenetic process in PJS polyp, and can be used as a sensitive biomarker for diagnosis and prognostic evaluation of PJS.
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Differentiation. Biomarkers / metabolism. Disease Progression. Female. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Young Adult

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  • (PMID = 19304549.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Biomarkers; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / leu-13 antigen
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71. Rhodes JM, Campbell BJ, Yu LG: Lectin-epithelial interactions in the human colon. Biochem Soc Trans; 2008 Dec;36(Pt 6):1482-6
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  • Similar changes in glycosylation occur in the colonic epithelium in inflammatory conditions such as ulcerative colitis and Crohn's disease and also in colon cancer and precancerous adenomatous polyps.
  • Tools are now available to allow fast and accurate elucidation of glycosylation changes in epithelial disease, characterization of their potential lectin ligands, whether dietary, microbial or human, and determination of the functional significance of their interactions.

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  • (PMID = 19021580.001).
  • [ISSN] 1470-8752
  • [Journal-full-title] Biochemical Society transactions
  • [ISO-abbreviation] Biochem. Soc. Trans.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Galectin 3; 0 / Lectins
  • [Number-of-references] 46
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72. Barone M, Tanzi S, Lofano K, Scavo MP, Guido R, Demarinis L, Principi MB, Bucci A, Di Leo A: Estrogens, phytoestrogens and colorectal neoproliferative lesions. Genes Nutr; 2008 Apr;3(1):7-13

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  • Very recently, the demonstration of an involvement of ER-beta in the development of adenomatous polyps of the colon has also been documented, suggesting the use of selective ER-beta agonists in primary colorectal cancer prevention.
  • These biological characteristics explain why the administration of phytoestrogens does not produce the classical side effects associated to estrogen administration (cerebro- and cardio-vascular accidents, higher incidence of endometrial and breast cancer) and makes these substances ideal candidates for the prevention of colorectal cancer.

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  • [Cites] Obstet Gynecol. 1996 May;87(5 Pt 2):897-904 [8677131.001]
  • [Cites] J Nutr. 1995 Sep;125(9):2307-15 [7666247.001]
  • [Cites] J Natl Cancer Inst. 1995 Jul 19;87(14):1067-71 [7616598.001]
  • [Cites] Proc Soc Exp Biol Med. 1995 Jan;208(1):40-3 [7892293.001]
  • [Cites] Annu Rev Biochem. 1994;63:451-86 [7979245.001]
  • [Cites] Cancer Causes Control. 1994 Jul;5(4):359-66 [8080948.001]
  • [Cites] Tohoku J Exp Med. 1993 Oct;171(2):153-65 [8128484.001]
  • [Cites] Genomics. 1993 Jul;17(1):263-5 [8406468.001]
  • [Cites] Int J Cancer. 2002 Oct 10;101(5):461-8 [12216075.001]
  • [Cites] JAMA. 2002 Jul 17;288(3):321-33 [12117397.001]
  • [Cites] J Biol Chem. 2002 Jul 5;277(27):24353-60 [11986316.001]
  • [Cites] N Engl J Med. 2003 Feb 13;348(7):618-29 [12584371.001]
  • [Cites] Mol Endocrinol. 2003 Feb;17(2):203-8 [12554748.001]
  • [Cites] Ann Intern Med. 2002 Nov 19;137(10):805-13 [12435217.001]
  • [Cites] Ann Intern Med. 1998 May 1;128(9):705-12 [9556463.001]
  • [Cites] Proc Soc Exp Biol Med. 1998 Mar;217(3):241-6 [9492331.001]
  • [Cites] Toxicol Ind Health. 1998 Jan-Apr;14(1-2):223-37 [9460177.001]
  • [Cites] Reprod Toxicol. 1997 Nov-Dec;11(6):815-22 [9407592.001]
  • [Cites] J Clin Endocrinol Metab. 1997 Dec;82(12):4258-65 [9398750.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 1997 Sep;6(9):671-5 [9298573.001]
  • [Cites] Annu Rev Nutr. 1997;17:353-81 [9240932.001]
  • [Cites] J Biol Chem. 1997 Oct 10;272(41):25832-8 [9325313.001]
  • [Cites] Cancer Causes Control. 1997 Mar;8(2):146-58 [9134238.001]
  • [Cites] Cancer Causes Control. 1997 Mar;8(2):130-8 [9134236.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 1996 Oct;5(10):779-84 [8896888.001]
  • [Cites] Arch Microbiol. 2000 Dec;174(6):422-8 [11195098.001]
  • [Cites] J Nutr. 2002 Mar;132(3):570S-573S [11880595.001]
  • [Cites] N Engl J Med. 2002 Jan 31;346(5):340-52 [11821512.001]
  • [Cites] J Nutr. 2001 Nov;131(11 Suppl):3095S-108S [11694655.001]
  • [Cites] J Am Acad Dermatol. 2001 Sep;45(3 Suppl):S116-24 [11511861.001]
  • [Cites] Vitam Horm. 2001;62:231-52 [11345900.001]
  • [Cites] Cancer Res. 2001 Mar 15;61(6):2547-51 [11289129.001]
  • [Cites] J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):287-96 [11162937.001]
  • [Cites] Biofactors. 2000;12(1-4):89-93 [11216511.001]
  • [Cites] Oncogene. 2000 Oct 12;19(43):4970-8 [11042684.001]
  • [Cites] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5936-41 [10823946.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):443-7 [10794491.001]
  • [Cites] Genes Dev. 2000 Jan 15;14(2):121-41 [10652267.001]
  • [Cites] Exp Cell Res. 1999 Dec 15;253(2):349-56 [10585257.001]
  • [Cites] Eur J Obstet Gynecol Reprod Biol. 1999 Nov;87(1):47-54 [10579616.001]
  • [Cites] Endocrinology. 1999 Dec;140(12):5566-78 [10579320.001]
  • [Cites] J Appl Microbiol. 2007 Oct;103(4):910-7 [17897193.001]
  • [Cites] J Nutr. 2007 May;137(5):1266-71 [17449591.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):684-93 [17416758.001]
  • [Cites] Endocr Relat Cancer. 2007 Mar;14(1):153-67 [17395984.001]
  • [Cites] J Nutr. 2006 Dec;136(12):3046-53 [17116718.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1132-6 [16775171.001]
  • [Cites] Carcinogenesis. 2005 Mar;26(3):587-95 [15579483.001]
  • [Cites] Baillieres Clin Endocrinol Metab. 1998 Dec;12(4):667-90 [10384819.001]
  • [Cites] Baillieres Clin Endocrinol Metab. 1998 Dec;12(4):605-23 [10384816.001]
  • [Cites] Proc Nutr Soc. 1999 Feb;58(1):139-46 [10343351.001]
  • [Cites] Am J Clin Nutr. 1998 Dec;68(6 Suppl):1333S-1346S [9848496.001]
  • [Cites] Endocrinology. 1998 Oct;139(10):4252-63 [9751507.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 1998 Apr;7(4):329-33 [9568789.001]
  • [Cites] Dis Colon Rectum. 1993 Jul;36(7):662-7 [8348850.001]
  • [Cites] Biochemistry. 1993 May 18;32(19):5074-82 [8494884.001]
  • [Cites] Cancer Causes Control. 1992 Jul;3(4):355-60 [1617123.001]
  • [Cites] Ital J Gastroenterol. 1992 Jan;24(1):8-12 [1571579.001]
  • [Cites] J Steroid Biochem. 1987;27(4-6):1135-44 [2826899.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Food Addit Contam. 1985 Apr-Jun;2(2):73-106 [4018320.001]
  • [Cites] Nature. 1982 Aug 12;298(5875):659-60 [6285206.001]
  • [Cites] Med Biol. 1981 Aug;59(4):259-61 [6279976.001]
  • [Cites] J Steroid Biochem Mol Biol. 2003 Aug;86(2):179-88 [14568570.001]
  • [Cites] Trends Pharmacol Sci. 2003 Sep;24(9):479-85 [12967773.001]
  • (PMID = 18850193.001).
  • [ISSN] 1555-8932
  • [Journal-full-title] Genes & nutrition
  • [ISO-abbreviation] Genes Nutr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2311500
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73. Colakoglu T, Yildirim S, Kayaselcuk F, Nursal TZ, Ezer A, Noyan T, Karakayali H, Haberal M: Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? Am J Surg; 2008 Jun;195(6):719-25
The Lens. Cited by Patents in .

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  • The relation between PTEN expression and Akt activation is still unclear in colorectal cancers and adenomatous polyps.
  • METHODS: PTEN and pAkt expression were evaluated in 76 primary colorectal cancers and 25 adenomatous colorectal polyp tissues using immunohistochemical staining on paraffin-embedded sections.
  • RESULTS: In colorectal cancers, pAkt expression was found to be significantly higher than polyps (P = .007).
  • On the other hand, PTEN expression was significantly lower in polyps (P <.0001).
  • A negative correlation between PTEN and pAkt expression was found in colon cancer patients (P = .010), whereas no significiant association was found in adenomatous polyps (P = .403).
  • No correlation of PTEN expression or pAkt expression was observed in Kaplan-Meier survival statistics and multivariate analyses for disease-free and overall survival.
  • [MeSH-minor] Adenomatous Polyps / genetics. Adenomatous Polyps / metabolism. Adult. Aged. Aged, 80 and over. Female. Gene Expression. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 18440486.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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74. Bafandeh Y, Khoshbaten M, Eftekhar Sadat AT, Farhang S: Clinical predictors of colorectal polyps and carcinoma in a low prevalence region: results of a colonoscopy based study. World J Gastroenterol; 2008 Mar 14;14(10):1534-8
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • [Title] Clinical predictors of colorectal polyps and carcinoma in a low prevalence region: results of a colonoscopy based study.
  • Adenomatous polyps were detected in 56 (11.7%) patients, in 12.3% of men and 10.9% of women.
  • The mean age of the patients with a polyp was significantly higher than the others (49.53 +/- 14.16 vs 41.85 +/- 16.26, P = 0.001).
  • Most of the adenomatous polyps were left sided and tubular; only 22.5% of polyps were more than 10 mm.
  • The mean age of patients with cancer was significantly higher than the others (60.25 +/- 8.26 vs 42.13 +/- 16.08, P < 0.005) and higher than patients with polyps [60.25 (8.26) vs 49.53 (1.91) (P < 0.0005)].
  • None of the symptoms (diarrhea, abdominal pain, rectal bleeding, constipation, altering diarrhea and constipation, history of cancer, known irritable bowel disease, history of polyp and fissure or family history of cancer) were predictors for cancer or polyps, but the age of the patient and unexplained anemia independently predicted cancer.
  • Colonic symptoms are not predictors for polyps or cancer but unexplained anemia and elder age can predict CRC.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / epidemiology. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology

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  • [Cites] Int J Colorectal Dis. 2000 Feb;15(1):29-34 [10766088.001]
  • [Cites] J Cancer Res Ther. 2005 Oct-Dec;1(4):204-7 [17998654.001]
  • [Cites] Am J Gastroenterol. 2000 Dec;95(12):3615-9 [11151901.001]
  • [Cites] East Mediterr Health J. 1999 Jul;5(4):766-77 [11338699.001]
  • [Cites] Public Health Nutr. 2002 Feb;5(1A):149-55 [12027278.001]
  • [Cites] Gastroenterol Clin North Am. 2002 Jun;31(2):565-86 [12134619.001]
  • [Cites] Dis Colon Rectum. 2002 Aug;45(8):1035-40 [12195187.001]
  • [Cites] J Korean Med Sci. 2002 Oct;17(5):604-10 [12378009.001]
  • [Cites] Gastroenterol Clin North Am. 2002 Dec;31(4):971-99 [12489273.001]
  • [Cites] J Med Assoc Thai. 2004 Jan;87(1):41-6 [14971533.001]
  • [Cites] Int J Cancer. 2004 May 1;109(5):777-81 [14999789.001]
  • [Cites] Dis Colon Rectum. 2004 Apr;47(4):481-5 [14994108.001]
  • [Cites] Am Surg. 2004 Mar;70(3):259-64 [15055851.001]
  • [Cites] ANZ J Surg. 2004 Jul;74(7):547-9 [15230787.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1215-22 [15247133.001]
  • [Cites] Am J Surg Pathol. 2004 Nov;28(11):1460-5 [15489649.001]
  • [Cites] Ann Surg. 1971 Dec;174(6):1002-8 [5132429.001]
  • [Cites] Am J Surg. 1976 Feb;131(2):185-91 [175719.001]
  • [Cites] Cancer. 1977 Jan;39(1):274-8 [832242.001]
  • [Cites] Cancer. 1977 May;39(5):2258-64 [870171.001]
  • [Cites] Pathol Annu. 1977;12 Pt 1:87-116 [917598.001]
  • [Cites] Cancer. 1988 Apr 1;61(7):1472-6 [3345499.001]
  • [Cites] Gastroenterology. 1991 Apr;100(4):1033-40 [2001800.001]
  • [Cites] Am J Gastroenterol. 1995 Mar;90(3):353-65 [7872270.001]
  • [Cites] Ann Intern Med. 1995 Dec 15;123(12):904-10 [7486484.001]
  • [Cites] Cancer. 1996 Sep 15;78(6):1187-94 [8826939.001]
  • [Cites] Int J Colorectal Dis. 1997;12(5):267-71 [9401839.001]
  • [Cites] Postgrad Med J. 2004 Nov;80(949):667-9 [15537853.001]
  • [Cites] Br J Surg. 2005 Apr;92(4):478-81 [15609377.001]
  • [Cites] BMC Cancer. 2005;5:52 [15913456.001]
  • [Cites] Asian Pac J Cancer Prev. 2005 Apr-Jun;6(2):130-4 [16101320.001]
  • [Cites] Aliment Pharmacol Ther. 2005 Nov 1;22(9):859-64 [16225496.001]
  • [Cites] Asian Pac J Cancer Prev. 2006 Jan-Mar;7(1):65-8 [16629518.001]
  • [Cites] Orv Hetil. 2006 Apr 23;147(16):741-6 [16711260.001]
  • [Cites] Asian Pac J Cancer Prev. 2006 Apr-Jun;7(2):309-12 [16839228.001]
  • [Cites] Cancer Lett. 2006 Aug 18;240(1):143-7 [16288832.001]
  • [Cites] J Epidemiol. 2006 Nov;16(6):240-8 [17085874.001]
  • [Cites] AJR Am J Roentgenol. 2007 Mar;188(3):619-21 [17312044.001]
  • [Cites] Dis Colon Rectum. 2007 Jul;50(7):990-5 [17525859.001]
  • [Cites] N Engl J Med. 2000 Jul 20;343(3):162-8 [10900274.001]
  • (PMID = 18330943.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2693747
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75. Khatibzadeh N, Ziaee SA, Rahbar N, Molanie S, Arefian L, Fanaie SA: The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps. J Cancer Res Ther; 2005 Oct-Dec;1(4):204-7
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • [Title] The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps.
  • BACKGROUND: The appropriate application of Endoscopic modalities for polypectomy depends on the likelihood that the adenoma in question harbors invasive cancer.
  • While prior studies have evaluated polyp size and morphology in assessing the risk of malignancy, in recent decay some authorities have paid more attention to dysplasia.
  • All in all, the relative risk of cancer based on polyp distribution in correlation with dysplasia has not been statistically studied which is done in our study.
  • METHODS AND MATERIALS: Between June 2001 and March 2004, the distribution of 130 adenomatous polyps was compared with synchronous invasive or in situ cancer.
  • Factors such as Patient age, Patients gender, location of lesion, size of polyp, histological subtype of adenoma on biopsy, degree of dysplasia, synchronous cancer, color of polyp, and number of polyps were included in the data collection.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17998654.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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76. Romano G, Cocchiara G, Maniaci S, Buscemi G, Calderone F, Gioè FP, Romano M: [The role of colonoscopy in patient follow-up after surgery for colorectal cancer. A retrospective study and review of the literature]. G Chir; 2007 Oct;28(10):399-402
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • To improve survival rate after colon or rectum resection for cancer patients should be strictly followed up in order to identify possible local disease relapse or metachronous neoplasia.
  • In addition, in 11 cases, there were 3 right colon adenomatous polyps, 2 transverse colon polyps (one villous and the other tubular), 5 descending colon polyps (three tubular and two villous) and 1 tubulo-villous polyp of the rectum.
  • An examination of the data resulting from our own 68 cases shows that, in spite of the fact that no local disease relapse or metachronous neoplasia was observed, the identification of 11 polyps would suggest that the use of colonoscopy in such patients might be the gold standard for early diagnosis of recurrences and new polyps.
  • [MeSH-minor] Aged. Colonic Polyps / diagnosis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Predictive Value of Tests. Retrospective Studies

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  • (PMID = 17915057.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 55
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77. Mutoh H, Hayakawa H, Sakamoto H, Sugano K: Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. J Gastroenterol; 2007 Sep;42(9):719-29

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: While cyclooxygenase-2 (COX-2) is not normally expressed by epithelial cells lining the human colon, COX-2 protein is aberrantly overexpressed in premalignant adenomatous polyps and carcinomas of the human colon.
  • However, the relationship between CDX2 attenuation and COX-2 overexpression in colorectal carcinoma has not been established.

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  • [Cites] Oncogene. 1999 Jan 7;18(1):87-92 [9926923.001]
  • [Cites] Gastroenterology. 2000 Sep;119(3):854-65 [10982779.001]
  • [Cites] J Immunol. 2005 Aug 15;175(4):2548-54 [16081828.001]
  • [Cites] Nat Rev Cancer. 2001 Oct;1(1):11-21 [11900248.001]
  • [Cites] Carcinogenesis. 1996 Aug;17(8):1757-60 [8761438.001]
  • [Cites] Gastroenterology. 2000 Oct;119(4):961-71 [11040183.001]
  • [Cites] J Biol Chem. 1998 May 29;273(22):14030-6 [9593754.001]
  • [Cites] Inflamm Res. 1998 Oct;47 Suppl 2:S112-6 [9831333.001]
  • [Cites] Biochem Biophys Res Commun. 1998 Mar 6;244(1):143-8 [9514889.001]
  • [Cites] Cancer. 1993 Jun 15;71(12):3827-38 [8508351.001]
  • [Cites] Nature. 1987 May 28-Jun 3;327(6120):293-7 [3587348.001]
  • [Cites] Cancer Res. 1996 Jun 1;56(11):2556-60 [8653697.001]
  • [Cites] Surgery. 2001 Aug;130(2):363-9 [11490372.001]
  • [Cites] Cell. 1990 Jun 1;61(5):759-67 [2188735.001]
  • [Cites] Biochem Biophys Res Commun. 2004 Feb 27;315 (1):93-9 [15013430.001]
  • [Cites] Cancer Res. 1996 Feb 15;56(4):710-4 [8631000.001]
  • [Cites] Biochem J. 1994 Sep 15;302 ( Pt 3):723-7 [7945196.001]
  • [Cites] Gastroenterology. 1994 Oct;107(4):1183-8 [7926468.001]
  • [Cites] J Biol Chem. 1996 Dec 27;271(52):33157-60 [8969167.001]
  • [Cites] Int J Cancer. 1997 Feb 20;74(1):35-44 [9036867.001]
  • [Cites] J Cell Biol. 1997 Dec 15;139(6):1553-65 [9396760.001]
  • [Cites] Annu Rev Pharmacol Toxicol. 2002;42:55-80 [11807164.001]
  • [Cites] Neuroscience. 1983 Oct;10(2):553-63 [6355896.001]
  • [Cites] Cell. 1996 Nov 29;87(5):803-9 [8945508.001]
  • [Cites] Mol Cell Biol. 1996 Feb;16(2):619-25 [8552090.001]
  • [Cites] Nucleic Acids Res. 1989 Aug 11;17(15):6419 [2771659.001]
  • [Cites] J Biol Chem. 1994 May 27;269(21):15229-37 [7910823.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Biochem Biophys Res Commun. 1994 Aug 30;203(1):190-9 [8074655.001]
  • [Cites] Surg Oncol. 1992 Aug;1(4):275-82 [1341261.001]
  • [Cites] Cancer Cell. 2004 Sep;6(3):203-8 [15380510.001]
  • [Cites] Anticancer Res. 2004 Mar-Apr;24(2B):675-81 [15161011.001]
  • [Cites] J Biol Chem. 1995 Oct 20;270(42):24965-71 [7559624.001]
  • [Cites] Nature. 1984 Aug 9-15;310(5977):469-75 [6462235.001]
  • [Cites] Am J Pathol. 1995 Sep;147(3):586-92 [7677172.001]
  • (PMID = 17876541.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / DNA, Neoplasm; 0 / Homeodomain Proteins; 0 / NF-kappa B; EC 1.14.99.1 / Cyclooxygenase 2
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78. Gonvers JJ, Harris JK, Wietlisbach V, Burnand B, Vader JP, Froehlich F, EPAGE Study Group: A European view of diagnostic yield and appropriateness of colonoscopy. Hepatogastroenterology; 2007 Apr-May;54(75):729-35
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  • Significant diagnoses included cancer, adenomatous polyps, angiodysplasia, and new diagnoses of inflammatory bowel disease.
  • There were 1,227 (24%) significant diagnoses made, including 218 (4%) cancers and 735 (14%) adenomatous polyps.
  • Having an appropriate indication, increasing age, and male sex increased the odds of finding a significant diagnosis at colonoscopy.

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  • (PMID = 17591050.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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79. Togashi K, Konishi F: Magnification chromo-colonoscopy. ANZ J Surg; 2006 Dec;76(12):1101-5
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  • In particular, the dye spray technique facilitates the detection of both flat hyperplastic polyps and highly dysplastic lesions.
  • However, magnification chromo-colonoscopy discriminates adenomas from hyperplastic polyps with greater accuracy than conventional methods by showing distinct and visible pit patterns.
  • The pit patterns are classified as types I, II, IIIL, IIIs, IV and V based on histological characterization of normal mucosa, hyperplastic polyp, polypoid adenoma, flat adenoma, tubulo-villous adenoma and cancerous tissue, respectively.
  • [MeSH-major] Colonic Neoplasms / surgery. Colonic Polyps / surgery. Colonoscopy / methods. Coloring Agents. Indigo Carmine

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  • (PMID = 17199698.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Coloring Agents; D3741U8K7L / Indigo Carmine
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80. Half EE, Arber N: Chemoprevention of colorectal cancer: two steps forward, one step back? Future Oncol; 2006 Dec;2(6):697-704
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  • The poor survival rate has prompted the emphasis on prevention of this disease.
  • Sulindac and celecoxib were shown to be effective in promoting polyp regression in high-risk individuals with familial adenomatous polyposis.
  • In the more common sporadic setting, the Adenomatous Polyp PRevention On Vioxx (rofecoxib), Adenoma Prevention with Celecoxib and Prevention of Sporadic Adenomatous Polyps (celecoxib) trials have demonstrated a significant reduction in adenoma recurrence, but important concerns were raised regarding cardiovascular toxicity associated with selective cyclo-oxygenase-2 inhibitors.
  • Currently, the only approved agent for chemoprevention is celecoxib in high-risk individuals with familial adenomatous polyposis.
  • [MeSH-major] Adenoma / prevention & control. Adenomatous Polyps / drug therapy. Anticarcinogenic Agents / therapeutic use. Colonic Polyps / drug therapy. Colorectal Neoplasms / prevention & control

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  • (PMID = 17155896.001).
  • [ISSN] 1479-6694
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 0 / Cyclooxygenase 2 Inhibitors
  • [Number-of-references] 59
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81. Lipton L, Tomlinson I: The genetics of FAP and FAP-like syndromes. Fam Cancer; 2006;5(3):221-6

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  • The presence of multiple adenomatous polyps in the large bowel confers a high lifetime risk of colorectal cancer.
  • Although many cases of classical familial adenomatous polyposis (> 100 polyps) can be accounted for by mutations in the adenomatous polyposis coli (APC) gene, a large group of patients remains with multiple (5-100) adenomas and in whom there is no detectable APC mutation.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Genes, APC / physiology. Neoplastic Syndromes, Hereditary / genetics

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  • (PMID = 16998667.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 36
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82. Goto H, Oda Y, Murakami Y, Tanaka T, Hasuda K, Goto S, Sasaki Y, Sakisaka S, Hattori M: Proportion of de novo cancers among colorectal cancers in Japan. Gastroenterology; 2006 Jul;131(1):40-6
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  • BACKGROUND & AIMS: Adenomatous polyps are main precursors of colorectal cancers (CRCs).
  • In Japan, de novo cancers, which do not arise from preexisting adenomas, are considered to account for a substantial number of CRCs, but the relative importance of de novo carcinogenesis remains controversial.
  • Early cancers among CRCs detected in this study were classified as de novo cancers or polyp cancers derived from adenomas.
  • There were no differences with regard to size and location between de novo cancers and polyp cancers, but morphology differed.
  • [MeSH-minor] Adult. Aged. Colonic Polyps / epidemiology. Colonic Polyps / pathology. Female. Humans. Incidence. Intestinal Mucosa / pathology. Japan / epidemiology. Male. Middle Aged. Retrospective Studies. Risk Factors. Sex Distribution

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  • [CommentIn] Gastroenterology. 2006 Oct;131(4):1361; author reply 1361-2 [17030215.001]
  • (PMID = 16831588.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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83. Souques M, Lassalle M, Guldner L, Asselain B, Barres D, Pavis C, Dubois G, Martin E, Fléjou JF: Colorectal polyps and cancers diagnosed by pathologists in Ile de France Region. Crisapif-Petri Study. Gastroenterol Clin Biol; 2006 Apr;30(4):587-93
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  • [Title] Colorectal polyps and cancers diagnosed by pathologists in Ile de France Region. Crisapif-Petri Study.
  • OBJECTIVES: The aim of this study was to evaluate the histological characteristics of adenomatous polyps (AP), non adenomatous polyps (NAP), and colorectal cancers (CRC) diagnosed in the greater Paris area.
  • MATERIAL AND METHODS: Pathologists filled out an identification and histological questionnaire for each biopsy or surgical specimen received between 20/09/02 and 20/12/02, which had at least one colorectal polyp or CRC, taken from a patient of the greater Paris area.
  • The mean number of polyps per patient was 1.4, and increased with age.
  • Average size of AP was larger than that of NAP and the size increased with age for AP but not NAP. pTNM staging of CRC was: pT0, 1% pT1, 4% pT2, 13% pT3, 63% pT4, 19% N0, 55% N1, 24% N2, 19% Nx, 2%.
  • CONCLUSION: This study provides detailed data on colorectal polyps and colorectal cancers in the greater Paris region, which does not have a cancer registry.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Adenomatous Polyps / pathology. Colonic Polyps / epidemiology. Colonic Polyps / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology

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  • (PMID = 16733383.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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84. Fidder HH, Figer A, Geva R, Flex D, Schayek H, Avidan B, Meir SB, Friedman E: Genetic analyses in consecutive israeli jewish colorectal cancer patients. Am J Gastroenterol; 2005 Jun;100(6):1376-80
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  • Whereas the I1307K variant is almost exclusively encountered in (Ashkenazi) Jews, E1317Q is not restricted to certain ethnic populations.
  • Carriers and noncarrier CRC patients did not differ in age of onset or associated colonic adenomatous polyps.
  • The 324delCA hMSH2 mutation was not observed in this cohort, and 4 of 322 Ashkenazi patients (1.2%) displayed the A636P mutation.
  • CONCLUSION: In Jewish CRC patients the E1317Q variant plays little if any role in colorectal cancer susceptibility and genetic testing for this variant is not warranted.
  • The I1307K mutation is associated with a moderate excess risk for CRC, but age of onset seems not to be earlier and this variant is not associated with a multiple colonic polyp phenotype.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Genetic Predisposition to Disease. Genotype. Humans. Israel / ethnology. Male. Middle Aged. Neoplasm Staging. Phenotype. Polymerase Chain Reaction. Retrospective Studies. Risk Factors

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  • (PMID = 15929773.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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85. Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK: Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis. Dis Colon Rectum; 2005 Apr;48(4):816-23
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  • [Title] Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
  • PURPOSE: In familial adenomatous polyposis, the long-term risk of pouch polyposis and potential for pouch cancer are unknown.
  • Our aim was to evaluate prospectively the prevalence, nature, and etiology of pouch ileal adenomas with that of nonpouch ileal adenomas in familial adenomatous polyposis.
  • METHODS: Sixty patients with familial adenomatous polyposis pouch, 47 familial adenomatous polyposis patients with ileorectal anastomosis, and 20 younger patients with familial adenomatous polyposis who had prophylactic colectomy were examined with videoendoscopy.
  • RESULTS: Adenomatous polyps were found in the pouches of 34 patients (57 percent).
  • A total of 362 polyps were identified (range, 0-50 per patient).
  • Most polyps were tubular adenomas with mild dysplasia, but 11 patients had more advanced histology, including two patients with large villous adenomas.
  • CONCLUSION: The risk of pouch cancer in familial adenomatous polyposis is unclear, but follow-up periods since surgery remain relatively short.
  • Long-term endoscopic surveillance of familial adenomatous polyposis pouches is thus recommended along with evaluation of potential therapeutic options for pouch adenomas.
  • [MeSH-major] Adenoma / epidemiology. Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / surgery. Colonic Pouches / pathology. Ileal Neoplasms / epidemiology. Proctocolectomy, Restorative

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  • (PMID = 15747076.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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86. Regev M, Barzilai SE, Figer A, Zidan J, Fidder HH, Friedman E: The I1307K APC mutation in a high-risk clinic setting: a follow-up study. Clin Genet; 2005 Apr;67(4):352-5
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  • Of these 29 cases, one individual was diagnosed with colon cancer at the age of 45 years, five had adenomatous polyps (mean number of polyps = 1.8), 11 had breast cancer (mean age at diagnosis 49.5 +/- 10.5 years), and 12 were asymptomatic, at the time of the testing.
  • During the follow-up period, new colonic polyps were diagnosed in three mutation carriers, two with previously diagnosed colon cancer and polyps and only one of the asymptomatic mutation carriers, and two additional previously affected patients had new cancer diagnoses: gastric cancer and melanoma.
  • From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors.
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / genetics. Colonic Polyps / genetics. Female. Follow-Up Studies. Heterozygote. Humans. Israel. Male. Middle Aged. Retrospective Studies. Risk

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  • (PMID = 15733272.001).
  • [ISSN] 0009-9163
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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87. Oh K, Redston M, Odze RD: Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. Hum Pathol; 2005 Jan;36(1):101-11
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  • [Title] Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon.
  • This mechanism has also recently been implicated in the newly postulated hyperplastic polyp-serrated adenoma-carcinoma ("serrated") pathway of carcinogenesis, although this has never been investigated thoroughly.
  • The aim of this study was to evaluate hMLH1, hMSH2, MGMT, as well as MIB-1, p53, and beta-catenin immunoexpression in an uncommon cohort of mixed colonic polyps that contain a combination of hyperplastic and adenomatous features (n = 21), and in some (n = 7), carcinoma as well.
  • DESIGN: The clinical, pathological, and immunophenotypic (hMLH1, hMSH2, MGMT, MIB-1, p53, and beta-catenin) properties of 28 mixed hyperplastic and adenomatous polyps of the colon (7 of which also contained carcinoma within the same lesion) were evaluated for the above immunopeptides in each of the different morphologic areas of the polyps, and the results were compared to traditional hyperplastic polyps, serrated adenomas, and conventional (nonserrated) adenomas.
  • RESULTS: Clinically, most mixed polyps with carcinoma occurred in the ascending colon (86%), and pathologically, the adenomatous component of most mixed polyps was serrated (96%).
  • Mixed polyps, particularly those with carcinoma, showed loss of hMLH1 (33%), MGMT (37%), and even hMSH2 (11%) with significantly higher frequency compared to hyperplastic polyps, conventional adenomas, and serrated adenomas.
  • More specifically, loss of hMLH1 and MGMT were more frequent in epithelium of higher neoplastic grade in mixed polyps.
  • However, hMSH2 loss was only present in the adenoma component and never in the hyperplastic or carcinomatous areas of these polyps.
  • Defects in MIB-1 proliferation indices and p53 were not significantly different among the same epithelial components in each of the polyp groups.
  • However, conventional adenomas showed significantly higher rates of nuclear beta -catenin staining (100%) in comparison to the adenomatous component of mixed polyps (60%).
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Colonic Neoplasms / genetics. Colonic Polyps / genetics. Gene Silencing. Neoplasm Proteins / genetics. O(6)-Methylguanine-DNA Methyltransferase / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Carcinoma / genetics. Carcinoma / metabolism. Carcinoma / pathology. Carrier Proteins. Cytoskeletal Proteins / metabolism. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Female. Humans. Hyperplasia / genetics. Hyperplasia / metabolism. Hyperplasia / pathology. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. MutS Homolog 2 Protein. Nuclear Proteins. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Trans-Activators / metabolism. Tumor Suppressor Protein p53 / metabolism. beta Catenin

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  • (PMID = 15712188.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CTNNB1 protein, human; 0 / Carrier Proteins; 0 / Cytoskeletal Proteins; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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88. Yuan B, Jin X, Zhu R, Zhang X, Liu J, Wan H, Lu H, Shen Y, Wang F: Cronkhite-Canada syndrome associated with rib fractures: a case report. BMC Gastroenterol; 2010;10:121
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  • Up till now, many complications of CCS have been reported in the literature, but rib fracture is not included.
  • Esophagogastroduodenoscopy, video capsule endoscopy and colonoscopy revealed various sizes of generalized gastrointestinal polyps.
  • Histological examination of the biopsy specimens obtained from the stomach and the colon showed adenomatous polyp and inflammatory polyp respectively.
  • Examinations, including emission computed tomography, bone densitometry test, and other serum parameters, were performed, but could not identify the definite etiology of the rib fractures.

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  • [Cites] Gastrointest Endosc. 2001 Sep;54(3):388-91 [11522989.001]
  • [Cites] Aliment Pharmacol Ther. 2002 Mar;16(3):333-42 [11876685.001]
  • [Cites] Expert Opin Pharmacother. 2003 Mar;4(3):385-9 [12614190.001]
  • [Cites] Am J Gastroenterol. 2003 Jun;98(6):1444-6 [12818298.001]
  • [Cites] Gastrointest Endosc. 2008 Mar;67(3):570-2 [18294523.001]
  • [Cites] Medicine (Baltimore). 1982 Sep;61(5):293-309 [7109958.001]
  • [Cites] Gastrointest Endosc. 1997 Dec;46(6):537-41 [9434222.001]
  • [Cites] N Engl J Med. 1955 Jun 16;252(24):1011-5 [14383952.001]
  • [Cites] Digestion. 2007;75(2-3):96-7 [17510553.001]
  • [Cites] Digestion. 2004;69(1):57-62 [14755154.001]
  • (PMID = 20955587.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2972238
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89. Durno CA, Holter S, Sherman PM, Gallinger S: The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations. Am J Gastroenterol; 2010 Nov;105(11):2449-56
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  • More than one-third of patients had multiple colorectal adenomas (>10 polyps).
  • This distinct phenotype includes multiple adenomatous polyps and CAL skin lesions.
  • [MeSH-major] Alleles. Colorectal Neoplasms / genetics. DNA Mismatch Repair. Genetic Predisposition to Disease. Germ-Line Mutation. Intestinal Neoplasms / genetics

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  • (PMID = 20531397.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Siddiqui A, Nazario HE, Patel M, Mahgoub A, Spechler SJ: Reduction in low-density lipoprotein cholesterol levels during statin therapy is associated with a reduced incidence of advanced colon polyps. Am J Med Sci; 2009 Nov;338(5):378-81
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  • [Title] Reduction in low-density lipoprotein cholesterol levels during statin therapy is associated with a reduced incidence of advanced colon polyps.
  • BACKGROUND: Elevated serum cholesterol levels may stimulate proliferation in adenomatous polyps (AP).
  • CONCLUSIONS: A reduction in LDL levels of > or=30% during a 3- to 5-year period of statin therapy was associated with a 53% reduction in the incidence of advanced APs, even after adjustment for other known polyp risk factors.
  • [MeSH-major] Cholesterol, LDL / blood. Colonic Polyps / blood. Hydroxymethylglutaryl-CoA Reductase Inhibitors / blood

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  • (PMID = 19794305.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cholesterol, LDL; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors
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91. Chan MY, Cohen H, Spiegel BM: Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital. Clin Gastroenterol Hepatol; 2009 Nov;7(11):1217-23; quiz 1143
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  • [Title] Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital.
  • BACKGROUND & AIMS: One objective of colonoscopy is to identify and remove polyps-this process requires attention to detail and prolonged concentration.
  • We measured the adjusted relationship between colonoscopy start time and polyp yield.
  • The primary outcome measure was polyp yield.
  • We identified significant risk factors using univariate analysis and performed Poisson multivariable regression to measure the independent effect of colonoscopy start time on polyp yield.
  • We evaluated evidence of decreasing polyp yield as the day progressed throughout pre-specified time intervals.
  • RESULTS: In univariate analysis, early-morning cases yielded 27% more polyps per patient than later cases (95% confidence interval, 11%-45%; P < .001).
  • The total numbers of, hyperplastic and adenomatous polyps found decreased hour-by-hour as the day progressed.
  • Multivariable analysis demonstrated that early-morning cases yielded 20% more polyps per patient than later cases (95% confidence interval, 5%-38%; P = .007).
  • CONCLUSIONS: At a VA medical center, more polyps were detected in patients that received colonoscopies early in the morning compared with later in the day.
  • Moreover, adenoma detection reduced as the day progressed.
  • Providers might be most adept at detecting polyps at the beginning of the day; further validation in other practice settings is required.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Colonoscopy. Diagnostic Errors / statistics & numerical data. Health Services Research. Polyps / diagnosis. Time Factors

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  • (PMID = 19631284.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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92. Ayanian JZ, Sequist TD, Zaslavsky AM, Johannes RS: Physician reminders to promote surveillance colonoscopy for colorectal adenomas: a randomized controlled trial. J Gen Intern Med; 2008 Jun;23(6):762-7
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

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  • BACKGROUND: Most colorectal cancers develop from adenomatous polyps.
  • National guidelines recommend surveillance colonoscopy within 5 years after such polyps are removed.
  • Among 358 patients whose physicians received reminders, 33 (9.2%) patients underwent colonoscopy within 6 months, compared with 16 (4.5%) of 359 patients whose physicians did not receive reminders (P = 0.009).
  • In prespecified subgroups, this effect did not differ statistically between 2 primary care networks, elderly and nonelderly patients, or women and men (all P > 0.60 by Breslow-Day test).
  • [MeSH-major] Adenomatous Polyps / diagnosis. Appointments and Schedules. Colonic Polyps / diagnosis. Colonoscopy / utilization. Colorectal Neoplasms / diagnosis. Reminder Systems

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  • [Cites] Gastrointest Endosc. 2000 Apr;51(4 Pt 1):433-7 [10744815.001]
  • [Cites] Arch Intern Med. 2007 Mar 12;167(5):507-12 [17353500.001]
  • [Cites] Gut. 2001 Jun;48(6):812-5 [11358901.001]
  • [Cites] J Gen Intern Med. 2001 Aug;16(8):531-7 [11556929.001]
  • [Cites] Ann Intern Med. 2002 May 7;136(9):641-51 [11992299.001]
  • [Cites] Gastroenterology. 2003 Feb;124(2):544-60 [12557158.001]
  • [Cites] Am J Med. 2003 Aug 1;115(2):129-33 [12893399.001]
  • [Cites] Med Care Res Rev. 2003 Sep;60(3):294-331 [12971231.001]
  • [Cites] Arch Intern Med. 2003 Dec 8-22;163(22):2733-6 [14662627.001]
  • [Cites] Ann Intern Med. 2004 Aug 17;141(4):264-71 [15313742.001]
  • [Cites] Cancer. 2004 Sep 1;101(5 Suppl):1188-200 [15316914.001]
  • [Cites] N Engl J Med. 1993 Apr 1;328(13):901-6 [8446136.001]
  • [Cites] N Engl J Med. 1993 Dec 30;329(27):1977-81 [8247072.001]
  • [Cites] N Engl J Med. 1995 Mar 30;332(13):861-7 [7870142.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 1999 Jul;8(7):587-93 [10428195.001]
  • [Cites] J Am Med Inform Assoc. 2005 Jul-Aug;12(4):431-7 [15802479.001]
  • [Cites] J Am Med Inform Assoc. 2006 Jan-Feb;13(1):5-11 [16221941.001]
  • [Cites] CA Cancer J Clin. 2006 Mar-Apr;56(2):106-30 [16514137.001]
  • [Cites] Arch Intern Med. 2006 Mar 27;166(6):675-81 [16567608.001]
  • [Cites] Gastroenterology. 2006 May;130(6):1872-85 [16697750.001]
  • [Cites] Arch Intern Med. 2006 Jul 10;166(13):1374-9 [16832002.001]
  • [Cites] Gastrointest Endosc. 2006 Oct;64(4):614-26 [16996358.001]
  • [Cites] Ann Intern Med. 2006 Nov 7;145(9):646-53 [17088577.001]
  • [Cites] Ann Intern Med. 2006 Nov 7;145(9):654-9 [17088578.001]
  • [Cites] Arch Intern Med. 2006 Nov 13;166(20):2237-43 [17101942.001]
  • [Cites] Arch Intern Med. 2006 Nov 13;166(20):2272-7 [17101947.001]
  • [Cites] Health Aff (Millwood). 2006 Nov-Dec;25(6):w496-507 [17035341.001]
  • [Cites] Ann Intern Med. 2007 Feb 20;146(4):270-7 [17310051.001]
  • [Cites] Prev Med. 2000 Oct;31(4):429-39 [11006069.001]
  • (PMID = 18386103.001).
  • [ISSN] 1525-1497
  • [Journal-full-title] Journal of general internal medicine
  • [ISO-abbreviation] J Gen Intern Med
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00397969
  • [Grant] United States / NCI NIH HHS / CA / R21 CA112365; United States / NCI NIH HHS / CA / R21-CA112365
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2517870
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93. Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland CR, Matsubara N: Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer; 2008 Jun 1;122(11):2429-36
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • Two methylation sensitive regions (Mp and Eh region) of MGMT promoter were investigated in 593 specimens of colorectal tissue: 233 CRCs, 104 adenomatous polyps (AP), 220 normal colonic mucosa from CRC patients (N-C) and 36 normal colonic mucosa specimens obtained from subjects without colorectal neoplasia (N-N) by combined bisulfite restriction analysis (COBRA).
  • Our data suggest that MGMT methylation may evolve and spread throughout the promoter in a stepwise manner as the colonic epithelial cells progress through the classical-adenoma-cancer multistep cascade.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • [Cites] Clin Cancer Res. 2003 Nov 1;9(14):5306-12 [14614014.001]
  • [Cites] Cancer Res. 2003 Aug 15;63(16):4842-8 [12941804.001]
  • [Cites] Clin Cancer Res. 2004 Mar 15;10(6):1871-4 [15041700.001]
  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] Cancer Res. 1990 Oct 1;50(19):6119-29 [2205376.001]
  • [Cites] Nucleic Acids Res. 1991 Nov 25;19(22):6163-7 [1956775.001]
  • [Cites] Cancer Res. 1992 Dec 1;52(23):6471-5 [1423294.001]
  • [Cites] Biochim Biophys Acta. 1994 Mar 1;1217(2):141-6 [8110828.001]
  • [Cites] Gastroenterology. 1997 Feb;112(2):594-642 [9024315.001]
  • [Cites] Mol Cell Biol. 1997 Sep;17(9):5612-9 [9271436.001]
  • [Cites] Cancer Res. 1997 Sep 1;57(17):3672-7 [9288770.001]
  • [Cites] Cancer Res. 1999 Feb 15;59(4):793-7 [10029064.001]
  • [Cites] Cancer Res. 1999 May 1;59(9):2029-33 [10232580.001]
  • [Cites] J Clin Oncol. 2004 Nov 15;22(22):4584-94 [15542810.001]
  • [Cites] Nat Rev Cancer. 2005 Mar;5(3):223-31 [15719030.001]
  • [Cites] N Engl J Med. 2005 Mar 10;352(10):997-1003 [15758010.001]
  • [Cites] Cancer Sci. 2005 Apr;96(4):206-11 [15819717.001]
  • [Cites] Gut. 2005 Jun;54(6):797-802 [15888787.001]
  • [Cites] Clin Cancer Res. 2005 Jul 15;11(14):5167-74 [16033832.001]
  • [Cites] J Natl Cancer Inst. 2005 Sep 21;97(18):1330-8 [16174854.001]
  • [Cites] Nature. 2007 Oct 25;449(7165):1073-7 [17960246.001]
  • [Cites] Cancer Res. 2000 May 1;60(9):2368-71 [10811111.001]
  • [Cites] N Engl J Med. 2000 Nov 9;343(19):1350-4 [11070098.001]
  • [Cites] Cancer Res. 2001 Feb 1;61(3):827-30 [11221863.001]
  • [Cites] Cancer Res. 2001 Jun 15;61(12):4689-92 [11406538.001]
  • [Cites] Gastroenterology. 2001 Dec;121(6):1300-9 [11729109.001]
  • [Cites] Cancer. 2001 Dec 1;92(11):2760-8 [11753949.001]
  • [Cites] Cancer Res. 2002 Feb 15;62(4):1166-70 [11861399.001]
  • [Cites] Gastroenterology. 2003 Mar;124(3):626-33 [12612901.001]
  • [Cites] Oncogene. 2003 Dec 4;22(55):8835-44 [14647440.001]
  • (PMID = 18240147.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01-CA98572; United States / NCI NIH HHS / CA / R01 CA098572; United States / NCI NIH HHS / CA / R01-CA72851; United States / NCI NIH HHS / CA / R01 CA072851-13; United States / NCI NIH HHS / CA / R01 CA072851; United States / NCI NIH HHS / CA / R01 CA098572-05; United States / NCI NIH HHS / CA / CA098572-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 3.6.5.2 / ras Proteins; EC 6.5.1.- / DNA Repair Enzymes
  • [Other-IDs] NLM/ NIHMS187517; NLM/ PMC2851179
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94. Abrahamson PE, King IB, Ulrich CM, Rudolph RE, Irwin ML, Yasui Y, Surawicz C, Lampe JW, Lampe PD, Morgan A, Sorensen BE, Ayub K, Potter JD, McTiernan A: No effect of exercise on colon mucosal prostaglandin concentrations: a 12-month randomized controlled trial. Cancer Epidemiol Biomarkers Prev; 2007 Nov;16(11):2351-6
Hazardous Substances Data Bank. PROSTAGLANDIN F2ALPHA .

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  • RESULTS: Baseline colon prostaglandin E(2) and F(2alpha) concentrations were not correlated with age, race, education, family history of colon cancer, previous polyps, body size, diet, smoking, nonsteroidal antiinflammatory drug use, metabolic factors, or sex hormone levels.
  • Results were not modified by baseline age, body mass index, percentage of body fat, nonsteroidal antiinflammatory drug use, history of adenomatous polyps, or family history of colon cancer.
  • CONCLUSION: A 12-month moderate-to-vigorous intensity aerobic exercise intervention did not result in significant changes in colon mucosal prostaglandin concentrations.

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  • (PMID = 18006923.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG1094; United States / NCRR NIH HHS / RR / M01-RR-00037; United States / NCI NIH HHS / CA / R01 CA77572; United States / NCI NIH HHS / CA / R25 CA94880
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] B7IN85G1HY / Dinoprost; K7Q1JQR04M / Dinoprostone
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95. Kuehle CA, Langhorst J, Ladd SC, Zoepf T, Nuefer M, Grabellus F, Barkhausen J, Gerken G, Lauenstein TC: Magnetic resonance colonography without bowel cleansing: a prospective cross sectional study in a screening population. Gut; 2007 Aug;56(8):1079-85
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  • Adenomatous polyps >5 mm were detected by means of MRC, with a sensitivity of 83.0%.
  • However, only 16 of 153 lesions <5 mm and 9 of 127 hyperplastic polyps could be visualised on magnetic resonance images.
  • It provides good accuracy for the detection of relevant (ie, adenomatous) colorectal lesions >5 mm in a screening population.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Aged. Aged, 80 and over. Colonoscopy / methods. Contrast Media. Cross-Sectional Studies. Diatrizoate Meglumine. Feces. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / pathology. Intestinal Polyposis / diagnosis. Intestinal Polyposis / pathology. Male. Mass Screening / methods. Middle Aged. Prospective Studies. Reference Standards. Sensitivity and Specificity

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  • [Cites] Am J Gastroenterol. 2003 Mar;98(3):578-85 [12650790.001]
  • [Cites] Invest Radiol. 2005 Feb;40(2):89-96 [15654253.001]
  • [Cites] Top Magn Reson Imaging. 2003 Oct;14(5):426-35 [14625469.001]
  • [Cites] Gut. 2003 Dec;52(12):1738-43 [14633953.001]
  • [Cites] N Engl J Med. 2003 Dec 4;349(23):2191-200 [14657426.001]
  • [Cites] Radiographics. 2004 Jan-Feb;24(1):e18 [14527992.001]
  • [Cites] CA Cancer J Clin. 2004 Jan-Feb;54(1):8-29 [14974761.001]
  • [Cites] JAMA. 2004 Apr 14;291(14):1713-9 [15082698.001]
  • [Cites] Eur Radiol. 2004 May;14(5):763-7 [14986051.001]
  • [Cites] Ann Intern Med. 2004 Aug 17;141(4):264-71 [15313742.001]
  • [Cites] Lancet. 2005 Jan 22-28;365(9456):305-11 [15664225.001]
  • [Cites] Radiology. 2005 Feb;234(2):452-9 [15591429.001]
  • [Cites] Dig Liver Dis. 2005 Feb;37(2):113-8 [15733524.001]
  • [Cites] Radiology. 2005 Apr;235(1):13-6 [15798163.001]
  • [Cites] Am J Prev Med. 2005 Jul;29(1):54-60 [15958253.001]
  • [Cites] Biochem Soc Trans. 2005 Aug;33(Pt 4):684-8 [16042574.001]
  • [Cites] Endoscopy. 2005 Sep;37(9):816-20 [16116531.001]
  • [Cites] N Engl J Med. 2000 Jul 20;343(3):162-8 [10900274.001]
  • [Cites] Gastroenterology. 2000 Aug;119(2):300-4 [10930364.001]
  • [Cites] Prev Med. 2000 Oct;31(4):323-34 [11006057.001]
  • [Cites] Semin Gastrointest Dis. 2000 Oct;11(4):176-84 [11057945.001]
  • [Cites] JAMA. 2001 Mar 28;285(12):1570-1 [11302136.001]
  • [Cites] Endoscopy. 2001 May;33(5):454-7 [11396767.001]
  • [Cites] Gastrointest Endosc. 2001 Sep;54(3):310-5 [11522970.001]
  • [Cites] Rofo. 2001 Sep;173(9):785-9 [11582556.001]
  • [Cites] AJR Am J Roentgenol. 2001 Nov;177(5):975-88 [11641151.001]
  • [Cites] AJR Am J Roentgenol. 2002 Feb;178(2):283-90 [11804881.001]
  • [Cites] Gastrointest Endosc. 2002 Mar;55(3):307-14 [11868001.001]
  • [Cites] Gastrointest Endosc Clin N Am. 2002 Jan;12(1):1-9, v [11916153.001]
  • [Cites] Eur Radiol. 2002 Jun;12(6):1410-5 [12042947.001]
  • [Cites] Radiology. 2006 Jan;238(1):143-9 [16304088.001]
  • [Cites] MMWR Morb Mortal Wkly Rep. 2006 Mar 24;55(11):308-11 [16557215.001]
  • [Cites] Radiology. 2004 Sep;232(3):735-8 [15273333.001]
  • [Cites] Br J Gen Pract. 1992 Jan;42(354):18-20 [1586526.001]
  • [Cites] Gastroenterology. 1997 Jan;112(1):24-8 [8978338.001]
  • [Cites] Lancet. 1997 May 3;349(9061):1288-91 [9142064.001]
  • [Cites] Eur J Clin Nutr. 1998 Aug;52(8):597-602 [9725661.001]
  • [Cites] Endoscopy. 1999 Feb;31(2):174-9 [10223369.001]
  • [Cites] J Magn Reson Imaging. 1999 Sep;10(3):477-84 [10508312.001]
  • [Cites] Radiology. 2004 Nov;233(2):328-37 [15358854.001]
  • [Cites] Eur Radiol. 2003 Apr;13(4):883-9 [12664130.001]
  • (PMID = 17341542.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 3X9MR4N98U / Diatrizoate Meglumine
  • [Other-IDs] NLM/ PMC1955492
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96. Peterlongo P, Mitra N, Sanchez de Abajo A, de la Hoya M, Bassi C, Bertario L, Radice P, Glogowski E, Nafa K, Caldes T, Offit K, Ellis NA: Increased frequency of disease-causing MYH mutations in colon cancer families. Carcinogenesis; 2006 Nov;27(11):2243-9
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  • [Title] Increased frequency of disease-causing MYH mutations in colon cancer families.
  • The genetic factors that cause clustering of colorectal cancers (CRCs) other than mutations in the mismatch repair (MMR) genes are not well understood.
  • Using Fisher's exact test and logistic regression, we compared the frequency of the known disease-causing MYH mutations Y165C, G382D and 466delE in 137 probands (117 cases with CRC and 20 cases diagnosed on the basis of adenomatous polyps only) from families with three or more CRCs but negative for mutations in the MMR genes and in 967 healthy controls with comparable ethnic backgrounds.
  • Adjusting for ethnic backgrounds, gender and age, the odds ratio associated with any disease-causing MYH mutation was 3.23 (P-value = 0.01); for mono-allelic carriers, it was 1.99 (P-value = 0.20).

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  • (PMID = 16774938.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA 103500; United States / NCI NIH HHS / CA / R03 CA103500-02; United States / NCI NIH HHS / CA / CA103394; United States / NCI NIH HHS / CA / R03 CA103500; United States / NCI NIH HHS / CA / CA103500-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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97. Alazmi W, Bustamante M, O'Loughlin C, Gonzalez J, Raskin JB: The association of Streptococcus bovis bacteremia and gastrointestinal diseases: a retrospective analysis. Dig Dis Sci; 2006 Apr;51(4):732-6
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  • However, SBB is also frequently associated with chronic liver disease and has been described with other gastrointestinal disorders.
  • The aim of the study was to evaluate the prevalence of gastrointestinal disease in patients with SBB.
  • Patients' clinical records were reviewed, with special focus on underlying gastrointestinal disease or other major comorbidities.
  • Nine adult patients (19%) had end-stage liver disease (five female).
  • Six patients had alcohol-induced liver disease (one with concomitant chronic hepatitis C), with the remaining three cases related to autoimmune hepatitis, primary biliary cirrhosis, and nonalcoholic steatohepatitis.
  • Colonic neoplasms (adenocarcinoma in 3 and adenomatous polyps in 3) were found in 6 of 10 adult patients in whom colonoscopic evaluation was performed.

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  • (PMID = 16614996.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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98. Gill S, Sinicrope FA: Colorectal cancer prevention: is an ounce of prevention worth a pound of cure? Semin Oncol; 2005 Feb;32(1):24-34
Hazardous Substances Data Bank. SELENIUM, ELEMENTAL .

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  • Colorectal carcinogenesis is a multistep process characterized by molecular and cellular alterations that result in an identifiable precursor lesion, ie, the adenomatous polyp.
  • The transition from normal mucosa to adenoma and its subsequent progression to carcinoma are protracted events that offer opportunities for preventive interventions.
  • Interest in this field derives from multiple epidemiologic studies showing that regular and continued use of nonsteroidal anti-inflammatory drugs (NSAIDs), predominantly aspirin, is associated with significant reductions in both colorectal adenoma and carcinoma incidence.
  • NSAIDs were first shown to be effective in patients with familial adenomatous polyposis (FAP).
  • Based on the aforementioned data, aspirin and coxibs have been or are currently being evaluated for the prevention of sporadic adenoma recurrence in high-risk patient populations.
  • Evidence indicates that aspirin can reduce adenoma recurrence rates in patients with prior colorectal neoplasia; however, questions remain, including the optimal dosage, timing of initiation and duration of treatment, and clinical benefit versus potential harm to patients.
  • Apart from aspirin, calcium carbonate is the only other agent that has been shown to modestly reduce sporadic adenoma recurrence rates in a randomized trial.
  • [MeSH-minor] Adenoma / pathology. Animals. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / therapeutic use. Calcium / therapeutic use. Clinical Trials as Topic. Cyclooxygenase Inhibitors / therapeutic use. Eflornithine / therapeutic use. Folic Acid / therapeutic use. Humans. Intestinal Mucosa / pathology. Selenium / therapeutic use. Ursodeoxycholic Acid / therapeutic use

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  • (PMID = 15726503.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 0 / Cyclooxygenase Inhibitors; 724L30Y2QR / Ursodeoxycholic Acid; 935E97BOY8 / Folic Acid; H6241UJ22B / Selenium; R16CO5Y76E / Aspirin; SY7Q814VUP / Calcium; ZQN1G5V6SR / Eflornithine
  • [Number-of-references] 122
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99. Slice LW, Chiu T, Rozengurt E: Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways. J Biol Chem; 2005 Jan 14;280(2):1582-93
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  • Cyclooxygenase-2 (COX-2) is aberrantly expressed in premalignant adenomatous polyps and colorectal carcinomas and is associated with increased epithelial cell proliferation, decreased apoptosis, and increased cell invasiveness.
  • Inhibition of ERK activation by U0126 or PD98059 significantly decreased EGF-dependent COX-2 expression, but did not affect Ang II-dependent COX-2 expression.
  • Conversely, inhibition of p38MAPK by SB202190 or PD169316 inhibited COX-2 expression by Ang II, but did not block COX-2 induction by EGF.
  • EGF did not induce Ca2+ mobilization, and 2-aminobiphenyl borate did not inhibit EGF-dependent COX-2 expression.

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  • (PMID = 15525649.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK017294; United States / NIDDK NIH HHS / DK / DK055003; United States / NIDDK NIH HHS / DK / DK056930; United States / NIDDK NIH HHS / DK / DK061485; United States / NIDDK NIH HHS / DK / DK063983
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptor, Angiotensin, Type 1; 11128-99-7 / Angiotensin II; 62229-50-9 / Epidermal Growth Factor; DCR9Z582X0 / Epoprostenol; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.6.5.2 / Monomeric GTP-Binding Proteins; EC 3.6.5.2 / cdc42 GTP-Binding Protein
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100. Ashktorab H, Begum R, Akhgar A, Smoot DT, Elbedawi M, Daremipouran M, Zhao A, Momen B, Giardiello FM: Folate status and risk of colorectal polyps in African Americans. Dig Dis Sci; 2007 Jun;52(6):1462-70
Hazardous Substances Data Bank. CYANOCOBALAMIN .

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  • [Title] Folate status and risk of colorectal polyps in African Americans.
  • Among 58 patients who underwent a clinically indicated colonoscopy, 23 patients with histology confirmed colorectal polyps and 35 patients without were recruited for a case-control study.
  • Polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) technique was performed to identify the MTHFR 677 C-->T polymorphism and specific PCR was used to analyze adenomatous polyposis coli (APC) gene-promoter sequence methylation.
  • Among 23 cases, 49 polyps (adenomatous, n = 41 and hyperplastic, n= 8) were identified.
  • Twenty-eight (57%) of the polyps were on the left side and 21 (42%) were on the right side of the colon.
  • There was no association between the presence of colon polyps and levels of folate (serum, RBC), vitamin B(12), or homocysteine.
  • Of these individuals, 18 (37.5%) had >/=1 colorectal polyps, whereas 30 (62.5%) had no polyps.
  • Nine individuals were heterozygous for 677 CT, and 4 (44%) of these individuals had colon polyps.
  • Among the individuals who showed APC methylation, 66% had polyps; 33% were polyp free using their blood DNA.
  • There was highly significant association between smoking and alcohol consumption with the presence of a colon polyp (P= .0006 and P= .05, respectively).
  • Smoking and alcohol consumption were found to be risk factors for colon polyps.
  • APC gene-promoter sequence methylation found in peripheral blood may be an indicator of risk for polyp formation and an important screening tool.
  • [MeSH-major] Adenoma / metabolism. African Americans. Colonic Polyps / metabolism. Colorectal Neoplasms / metabolism. Folic Acid / metabolism. Genes, APC. Tetrahydrofolates / genetics

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  • MedlinePlus Health Information. consumer health - Folic Acid.
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  • (PMID = 17372834.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Grant] United States / PHS HHS / / U54 A91431
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tetrahydrofolates; 0 / Vitamins; 0LVT1QZ0BA / Homocysteine; 0SXY5ET48B / 5,10-methylenetetrahydrofolic acid; 935E97BOY8 / Folic Acid; P6YC3EG204 / Vitamin B 12
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