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1. Souques M, Lassalle M, Guldner L, Asselain B, Barres D, Pavis C, Dubois G, Martin E, Fléjou JF: Colorectal polyps and cancers diagnosed by pathologists in Ile de France Region. Crisapif-Petri Study. Gastroenterol Clin Biol; 2006 Apr;30(4):587-93
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  • [Title] Colorectal polyps and cancers diagnosed by pathologists in Ile de France Region. Crisapif-Petri Study.
  • OBJECTIVES: The aim of this study was to evaluate the histological characteristics of adenomatous polyps (AP), non adenomatous polyps (NAP), and colorectal cancers (CRC) diagnosed in the greater Paris area.
  • MATERIAL AND METHODS: Pathologists filled out an identification and histological questionnaire for each biopsy or surgical specimen received between 20/09/02 and 20/12/02, which had at least one colorectal polyp or CRC, taken from a patient of the greater Paris area.
  • The mean number of polyps per patient was 1.4, and increased with age.
  • Average size of AP was larger than that of NAP and the size increased with age for AP but not NAP. pTNM staging of CRC was: pT0, 1% pT1, 4% pT2, 13% pT3, 63% pT4, 19% N0, 55% N1, 24% N2, 19% Nx, 2%.
  • CONCLUSION: This study provides detailed data on colorectal polyps and colorectal cancers in the greater Paris region, which does not have a cancer registry.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Adenomatous Polyps / pathology. Colonic Polyps / epidemiology. Colonic Polyps / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology

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  • (PMID = 16733383.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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2. Barreda B F, Combe G J, Valdez P LA, Sánchez L J: [Clinical aspects in polyps of the colon]. Rev Gastroenterol Peru; 2007 Apr-Jun;27(2):131-47
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  • [Title] [Clinical aspects in polyps of the colon].
  • INTRODUCTION: The colonics polyps according to their number, size, location, age of presentation and mainly, according to their histology, have the potentiality of malignant degeneration, which makes of a continuous study and pursuit susceptible.
  • OBJECTIVES: To evaluate the relation between the histologic type of the colon polyps, its location, the degree of dysplasia, the size, its possible commitment by carcinoma, the age, sex and the handling that has occurred them, in a series of 684 patients of the National Institute of Enfermedades Neoplásicas (INEN) between the 1 of January from 1974 to the 31 of March of the 2004.
  • MATERIAL AND METHODS: The revision of clinical histories of 840 patients with the diagnosis of colon polyp was made who attended the service of Gastroenterology of the INEN between the 1 of January from 1974 to the 31 of March of 2004 and a card predesigned for each clinical history filled.
  • 1162 resecteds polyps evaluated themselves in this period.
  • 156 patients by diagnosis related to cancer and familiar adenomatouspoliposis did not include themselves.
  • The final sample was of 684 patients, in whom it was 1057 polyps.
  • RESULTS: 1057 polyps extirpated, by means of the endoscopy polipectomy were 1016, with colectomy were 32 and with transanal resection without colectomy they 9.
  • Within the histology of the 1057 polyps, 331 was briefed (31.3%) that were hyperplasic, 448 (42.4%) adenomas, 278 (26.3%) others and 35 (8.2%) adenocarcinomas on adenomas.
  • Adenocarcinoma (carcinomas on adenomas), was present mainly in polyps villous type, with dysplasia severe and greater to 10 mm.
  • Nevertheless, in smaller polyps of 5mm with dysplasia severe, was a polyp invaded by cancer, that represents the 0,8% of millimetric polyps.
  • The made handling was mainly endoscopic, with 96% of the resected polyps this way, also slogan transanal resection and segmental colonic resection.
  • The colectomy was necessary in 3% of all the made interventions, dysplasia severe or carcinoma was made in adenomatous polyps with, and in greater percentage in greater polyps of 20 mm (53%).
  • On the other hand, in polyps with level of invasion Haggitt 3 and 4, the colectomy was the election treatment.
  • CONCLUSIONS: The Evaluation of colonic polyps in INEN is predominantly by endoscopy.
  • The polyps are more frequent over the 50 years and have preferred location in the left colon.
  • The carcinoma is more probable with severe dysplasia and greater size of the adenoma.
  • All polyps, from the millimetric ones, including the hyperplasic, must be considered marks of neoplasia and extirpated in its totality.
  • [MeSH-major] Colonic Polyps / pathology. Colonic Polyps / surgery

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  • (PMID = 17712391.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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3. Schatzkin A: Problems with using biomarkers as surrogate end points for cancer: a cautionary tale. Recent Results Cancer Res; 2005;166:89-98
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  • Inferences to cancer from such downstream markers as colorectal adenomatous polyps and persistent human papillomavirus infection of the cervix are strong, though not absolutely unassailable.
  • [MeSH-minor] Disease Progression. Humans

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  • (PMID = 15648185.001).
  • [ISSN] 0080-0015
  • [Journal-full-title] Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
  • [ISO-abbreviation] Recent Results Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 14
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4. Vakhrushev IaM, Kniazeva BG: [The peculiarities of the contents of the gastric mucus in patients with gastric polyps]. Klin Med (Mosk); 2007;85(4):49-52
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  • [Title] [The peculiarities of the contents of the gastric mucus in patients with gastric polyps].
  • Complex study of the components of the gastric mucus in 60 patients with gastric polyps was studied.
  • The degree of the changes in the gastric mucus was higher in patients with adenomatous polyps vs. hyperplastic ones.
  • [MeSH-major] Gastric Mucosa / pathology. Mucus. Polyps / pathology. Stomach Diseases / pathology

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  • (PMID = 17564039.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Glycosaminoglycans
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5. Ghelase F, Mogoş DS, Mărgăritescu D, Iordache S, Ghelase MS, Râmboiu S, Mogoş G, Bică M, Săftoiu A, Georgescu I: [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications]. Chirurgia (Bucur); 2009 Mar-Apr;104(2):159-65
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  • [Title] [Correlation of adenomatous polyps and early colorectal cancer. Diagnostic and therapeutic implications].
  • AIM: To detect the patients with colorectal adenomatous polyps or those with adenocarcinoma areas with a view to prevent and to treat the malignant disease.
  • MATERIAL AND METHOD: A prospective study including 309 patients hospitalized between 2000-2005 diagnosed with isolated adenomatous polyps after repeated colonoscopies.
  • The research method was selective screening with identification of risk factors regarding the evolution of colorectal polyps in early cancer, using colonoscopy and histopathological examination.
  • RESULTS: We identified 464 single or multiple isolated polyps of which 399 were adenomas, 59 hyperplastic polyps and 6 other types of lesions.
  • Histologically we recorded 41 (13.27%) polyps with a low grade of dysplasia, 56 (18.12%) with severe dysplasia and 30 (9.7%) intramucosal adenocarcinoma with submucosal invasion.
  • TREATMENT: Colonoscopic polypectomy was used for benign polyps and in situ carcinoma.
  • CONCLUSIONS: High grade of dysplasia, the number of polyps, ulceration, bleeding, intraepithelial areas of neoplastic transformation are predictive factors for early colorectal cancer.
  • Depth of submucosal invasion of malignant transformed polyps are important pathological factors to predict lymphatic metastasis and to select the therapeutic procedure.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Colectomy / methods. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Cell Transformation, Neoplastic / pathology. Colonic Polyps / diagnosis. Colonic Polyps / surgery. Female. Humans. Male. Prospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 19499658.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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6. Rozen P, Comaneshter D, Levi Z, Hazazi R, Vilkin A, Maoz E, Birkenfeld S, Niv Y: Cumulative evaluation of a quantitative immunochemical fecal occult blood test to determine its optimal clinical use. Cancer; 2010 May 1;116(9):2115-25
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  • The objective was to evaluate sensitivity and specificity for CRC and advanced adenomatous polyps (APs) by the fecal Hb threshold used to determine a positive test and the number of IFOBTs prepared per test, so as to determine the least number of colonoscopies required to detect a neoplasm.
  • Limitations are 1-time screening and most examinees not being at average risk for CRC.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Colorectal Neoplasms / diagnosis. Occult Blood
  • [MeSH-minor] Colonic Polyps / diagnosis. Colonoscopy. Early Detection of Cancer. Hemoglobins / analysis. Humans. Immunohistochemistry. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • [Copyright] (c) 2010 American Cancer Society.
  • (PMID = 20186820.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins
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7. Hao Y, Jemal A, Zhang X, Ward EM: Trends in colorectal cancer incidence rates by age, race/ethnicity, and indices of access to medical care, 1995–2004 (United States). Cancer Causes Control; 2009 Dec;20(10):1855-63
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  • This is largely thought to reflect increases in utilization of CRC screening through detection and removal of adenomatous polyps.
  • RESULTS: Among whites, CRC incidence rates decreased significantly from 1998 through 2004 in age ≥ 65, but not in age 50-64 in counties with high uninsured or poverty rates, fewer PCPs, or in nonmetro areas.
  • Among African Americans or Hispanics, rates did not decrease in age 50-64 in general and age ≥ 65 in counties with high poverty rates, low PCP supply, and nonmetro counties (African Americans).
  • Colorectal endoscopic screening rates increased significantly among whites in both age groups, but not among Hispanics (aged 50-64 in general and aged ≥ 65 residing in high poverty counties) or African Americans residing in counties with higher uninsured rates (age 50-64), low PCP supply, high poverty rates, and nonmetro counties (age ≥ 65).
  • CONCLUSIONS: Our results suggest that individuals residing in poorer communities with lower access to medical care have not experienced the reduction in CRC incidence rates that have benefited more affluent communities; these disparities may be related to health care access barriers to colorectal endoscopic screening.

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  • (PMID = 19543799.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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8. Martínez ME, Jacobs ET, Ashbeck EL, Sinha R, Lance P, Alberts DS, Thompson PA: Meat intake, preparation methods, mutagens and colorectal adenoma recurrence. Carcinogenesis; 2007 Sep;28(9):2019-27
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  • [Title] Meat intake, preparation methods, mutagens and colorectal adenoma recurrence.
  • We prospectively assessed the relation between type of meat, meat preparation method, doneness, a metric of HCAs and other mutagens and colorectal adenoma recurrence among 869 participants in a chemoprevention trial of ursodeoxycholic acid.
  • Most meat variables assessed were positively but weakly associated with recurrence of any adenoma.
  • Our results support a meat mutagen exposure hypothesis as a potential mechanism for recurrence of clinically significant adenomatous polyps.
  • [MeSH-major] Adenoma / epidemiology. Colorectal Neoplasms / epidemiology. Cooking / methods. Meat / analysis. Mutagens / analysis

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  • (PMID = 17690112.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-23074; United States / NCI NIH HHS / CA / CA-41108; United States / NCI NIH HHS / CA / CA106269; United States / NCI NIH HHS / CA / CA95060
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Mutagens; 724L30Y2QR / Ursodeoxycholic Acid
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9. Lee SS, Park SH, Choi EK, Kim SY, Kim MJ, Lee KH, Kim YH: Colorectal polyps on portal phase contrast-enhanced CT colonography: lesion attenuation and distinction from tagged feces. AJR Am J Roentgenol; 2007 Jul;189(1):35-40
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  • [Title] Colorectal polyps on portal phase contrast-enhanced CT colonography: lesion attenuation and distinction from tagged feces.
  • OBJECTIVE: The purpose of our study was to determine the attenuation of colorectal polyps on portal phase contrast-enhanced CT colonography (CTC) and evaluate whether enhanced polyps can be clearly distinguished from tagged feces during CTC review.
  • Forty-eight colonoscopy-proven polyps (6-20 mm) and 41 polypoid tagged feces (6-19 mm) were selected from contrast-enhanced CTC performed without (n = 37 examinations) and with (n = 10 examinations) fecal tagging, respectively.
  • Attenuation of the polyps and tagged feces was measured.
  • Four independent blinded radiologists reviewed the polyps and tagged feces at both wide (width, 1,500 H; level -400 H) and soft-tissue (width, 400 H; level, 20 H) window settings to distinguish them by using subjective visual assessment.
  • RESULTS: Polyp attenuation on the portal phase was not correlated with size (R = -0.003; p = 0.99) and was not different between histologic types (p = 0.884).
  • Enhanced polyps (mean +/- SD, 119.9 +/- 25.3 H; range, 50-173 H) showed significantly lower attenuation than did tagged feces (1,521.4 +/- 683.6 H; range, 495-2,683 H) without any overlap (p < 0.0005).
  • An 8-mm sessile adenomatous polyp was misinterpreted as tagged feces by one reviewer.
  • CONCLUSION: Polyp attenuation on portal phase contrast-enhanced CTC ranges from 50 to 173 H.
  • Contrast-enhanced polyps are clearly and consistently distinguished from barium-tagged polypoid feces.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic / methods. Contrast Media / administration & dosage. Feces. Radiographic Image Enhancement / methods. Rectal Diseases / radiography

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  • (PMID = 17579149.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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10. Nowicki MJ, Bishop PR, Subramony C, Wyatt-Ashmead J, May W, Crawford M: Colonic chicken-skin mucosa in children with polyps is not a preneoplastic lesion. J Pediatr Gastroenterol Nutr; 2005 Nov;41(5):600-6
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  • [Title] Colonic chicken-skin mucosa in children with polyps is not a preneoplastic lesion.
  • Colonic polyps are common both in adults and children; however, the malignant potential varies according to the type of polyp.
  • Most childhood polyps are solitary juvenile polyps, which have negligible malignant potential.
  • Chicken-skin mucosa (CSM) is an endoscopic finding initially described associated with adenomatous polyps and adenocarcinoma, suggesting a preneoplastic lesion.
  • Subsequently, CSM was described in association with juvenile polyps, suggesting that this mucosal finding is not a precursor to dysplasia.
  • The association of CSM with benign juvenile polyps and the absence of histologic markers for increased replication and malignant transformation support the notion that this endoscopic finding is not preneoplastic.
  • Rather, CSM arises in proximity to polyps of all histologic types because of local mucosal damage.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology. Intestinal Mucosa / pathology. Ki-67 Antigen / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / analysis. Biopsy. Child. Child, Preschool. Colon / pathology. Colonoscopy. Female. Humans. Immunohistochemistry. Male. Prospective Studies

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  • (PMID = 16254516.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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11. Gryfe R: Overview of colorectal cancer genetics. Surg Oncol Clin N Am; 2009 Oct;18(4):573-83
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  • Cancer is a genetic disease in which the clonal accumulation of genetic alterations confers a cell with the malignant characteristics of uncontrolled growth, local invasiveness, and metastastic potential.
  • Studies of colorectal cancer and its precursor lesion, the adenomatous polyp, have served as the cornerstone in advancing knowledge of cancer molecular genetics.

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  • (PMID = 19793566.001).
  • [ISSN] 1558-5042
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Number-of-references] 81
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12. Gupta S: Colorectal polyps: the scope and management of the problem. Am J Med Sci; 2008 Nov;336(5):407-17
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  • [Title] Colorectal polyps: the scope and management of the problem.
  • Much of the benefit of colorectal cancer screening has been attributed to detection and removal of adenomatous polyps, highlighting the importance of colorectal polyps as targets for intervention and as biomarkers for colorectal cancer risk.
  • This review details the epidemiology of sporadic colorectal polyps, rationale behind use of polyps as an important surrogate for colorectal cancer risk, the benefits and limitations of secondary prevention of colorectal polyps through chemopreventive and dietary interventions, as well as colon surveillance.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonic Polyps / surgery. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / prevention & control
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / epidemiology. Adenoma / pathology. Adenoma / prevention & control. Congresses as Topic. Cyclooxygenase Inhibitors / therapeutic use. Diet. Humans. Mass Screening. Middle Aged. Risk Factors. Sigmoidoscopy

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  • (PMID = 19011398.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1 KL2 RR024983-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors
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13. Dhar A, Johnson KS, Novelli MR, Bown SG, Bigio IJ, Lovat LB, Bloom SL: Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique. Gastrointest Endosc; 2006 Feb;63(2):257-61
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  • We assessed the diagnostic potential of ESS in the colon to differentiate normal colonic mucosa, chronic colitis, hyperplastic polyps, adenomatous polyps (with dysplasia), and adenocarcinoma.
  • They were then compared with conventional biopsy specimens taken from the same site, including normal colonic mucosa, hyperplastic polyps, adenomatous polyps, chronic colitis, and colon cancer.
  • RESULTS: A total of 483 spectra were analyzed (290 normal, 19 hyperplastic, 69 adenomatous polyps, 74 chronic colitis, and 31 colorectal cancer).
  • The sensitivity and the specificity of differentiating adenomas from hyperplastic polyps was 84% and 84%, respectively; for cancer from adenomatous polyps, 80% and 75%, respectively; for colitis from normal tissue, 77% and 82%, respectively; and for dysplastic mucosa (from polyps) from colitis, 85% and 88%, respectively.
  • It could prove a valuable aid for targeting biopsies in dysplasia surveillance in inflammatory bowel disease and for deciding which small polyps should be removed.

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  • (PMID = 16427931.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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14. Zhou PH, Yao LQ, Chen WF: [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum]. Zhonghua Wai Ke Za Zhi; 2008 Sep 15;46(18):1386-9
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  • [Title] [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum].
  • OBJECTIVE: To assess the clinical efficacy of endoscopic treatment for colorectal adenomatous polyps and early-stage carcinomas.
  • METHODS: Between January 2006 and October 2007, 245 patients with colorectal adenomatous polyps and early-stage carcinomas with lifting sign(+) were treated by such endoscopic techniques as polypectomy, endoscopic mucosal resection (EMR), endoscopic piecemeal mucosal resection (EPMR) and endoscopic submucosal dissection (ESD).
  • CONCLUSIONS: Endoscopic resection appears to be an efficacious procedure to treat adenomatous polyp and early-stage carcinoma and provide pathological information about the whole lesion.
  • [MeSH-major] Adenomatous Polyps / surgery. Colorectal Neoplasms / surgery. Endoscopes, Gastrointestinal

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  • (PMID = 19094508.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Tam YH, Lee KH, Chan KW, Sihoe JD, Cheung ST, Mou JW: Colonoscopy in Hong Kong Chinese children. World J Gastroenterol; 2010 Mar 7;16(9):1119-22
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  • AIM: To investigate the safety and diagnostic yield of colonoscopy in Chinese children in whom the procedure is not often done.
  • Forty patients (50.6%) had a positive diagnosis made in colonoscopy and that included colonic polyps (23), Crohn's disease (12), ulcerative colitis (1), and miscellaneous causes (4).
  • 80% of polyps were in the rectosigmoid colon.
  • All but one were juvenile hamartomatous polyps.
  • The exception was an adenomatous polyp.
  • The mean ages for children with inflammatory bowel disease (IBD) and polyps were 11.3 and 4.3 years respectively.
  • The increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonoscopy. Inflammatory Bowel Diseases / diagnosis

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  • (PMID = 20205284.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2835790
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16. Głuszko P, Bielińska A: Non-steroidal anti-inflammatory drugs and the risk of cardiovascular diseases: are we going to see the revival of cyclooxygenase-2 selective inhibitors? Pol Arch Med Wewn; 2009 Apr;119(4):231-5
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  • In 2004 and 2005, predictions of some pharmacologists were confirmed when the Adenomatous Polyp Prevention on VIOXX trial (APPROVE) and other randomized, double-blind, placebo-controlled trials with COX-2 inhibitors showed an increased rate of thrombotic vascular events, including myocardial infarction, in patients treated with coxibs.

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  • (PMID = 19413182.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors
  • [Number-of-references] 23
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17. Mitrou PN, Watson MA, Loktionov AS, Cardwell C, Gunter MJ, Atkin WS, Macklin CP, Cecil T, Bishop TD, Primrose J, Bingham SA: MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom). Cancer Causes Control; 2006 Aug;17(6):793-801
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  • [Title] MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom).
  • OBJECTIVE: The purpose of this study was to further evaluate the role of low activity MTHFR variants as well as to explore interactive effects between alcoholic drink consumption and MTHFR variants and risk of distal colorectal adenomatous polyps.
  • METHODS: We examined the relationship between MTHFR C677T and A1298C gene polymorphisms and risk of distal adenomas in one of the largest case control studies of 946 polyp-free controls and 894 cases, all participants of the UK Flexible Sigmoidoscopy Screening Trial (UKFSS).
  • RESULTS: Investigation of the effect of the MTHFR C677T polymorphism in this large UKFSS study revealed no overall association on adenoma risk (P>0.05).
  • CONCLUSIONS: In this, the largest study of these polymorphisms in relation to colorectal adenoma, there was no evidence for an interaction with alcohol in combination with the variant forms of MTHFR (P>0.05).
  • [MeSH-major] 5,10-Methylenetetrahydrofolate Reductase (FADH2) / genetics. Adenoma / genetics. Adenomatous Polyps / genetics. Colorectal Neoplasms / genetics. Polymorphism, Single Nucleotide / genetics
  • [MeSH-minor] Aged. Alcohol Drinking. Case-Control Studies. Female. Gene Frequency. Genetic Predisposition to Disease. Humans. Male. Mass Screening. Middle Aged. Risk Factors. Sigmoidoscopy / methods

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  • (PMID = 16783607.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / A4994; United Kingdom / Medical Research Council / / G9615910
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 1.5.1.20 / 5,10-Methylenetetrahydrofolate Reductase (FADH2)
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18. Rastogi A, Pondugula K, Bansal A, Wani S, Keighley J, Sugar J, Callahan P, Sharma P: Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology. Gastrointest Endosc; 2009 Mar;69(3 Pt 2):716-22
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  • [Title] Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology.
  • BACKGROUND: The 2 main types of colon polyps are adenomas and hyperplastic.
  • Pit patterns on the surface of polyps have been described by using magnification chromoendoscopy, which can help differentiate between polyp types.
  • Narrow band imaging (NBI) is a novel technology that enhances the visualization of surface mucosal and vascular patterns on the polyp surface.
  • Earlier we described, in a pilot study, patterns seen on the polyp surface with NBI that can help differentiate between adenomas and hyperplastic polyps with a high degree of accuracy.
  • OBJECTIVE: The aim of this study was to evaluate the interobserver and intraobserver agreement (among endoscopists) for the NBI surface mucosal and vascular patterns and prediction of polyp histology and the accuracy of the investigators to predict polyp histology based on these patterns.
  • METHODS: NBI images of the polyp surface mucosal and vascular patterns obtained in our pilot trial were retrieved.
  • A teaching set of 20 images was selected to educate and demonstrate the polyp patterns to 4 endoscopists.
  • Subsequently, the test set of images was evaluated by the 4 endoscopists for quality, polyp pattern, and prediction of polyp type.
  • Interobserver agreement (k value) was calculated among the 4 assessors for the polyp patterns and predicted histology.
  • By using the final histology as the criterion standard, the accuracy of polyp-type prediction was calculated for each assessor.
  • After a period of 2 months, all polyp images were reevaluated by the assessors (as before), and all findings were recorded in a similar fashion.
  • These results were used for calculation of intraobserver agreement (k value) and the accuracy of the assessors in predicting polyp type.
  • RESULTS: Photographs of 65 polyps were included in the test set and were evaluated by the 4 assessors.
  • Thirty-eight polyps were adenomatous, and 27 were hyperplastic.
  • The kappa value for the interobserver agreement for polyp surface pattern was 0.57 (moderate) and for prediction of polyp type was 0.63 (substantial).
  • The kappa value for the intraobserver agreement of the 4 assessors for the surface patterns was 0.70, 0.65, 0.60, and 0.79, and for the prediction of polyp type was 0.87, 0.71, 0.61, 0.81.
  • The accuracy to predict polyp type ranged from 80% to 86% for the 4 assessors in the first reading and from 85% to 91% in the second reading, with every assessor showing an improvement in accuracy in the second reading.
  • LIMITATIONS: A single-center study, with a limited number of polyps.
  • CONCLUSIONS: This initial evaluation showed that the NBI polyp patterns described in our pilot study are reproducible, easy to learn, reasonably accurate, and have the potential for use in daily clinical practice for the real-time differentiation of colon polyps.
  • [MeSH-major] Colonic Polyps / pathology. Colonoscopy / statistics & numerical data

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  • [CommentIn] Gastrointest Endosc. 2009 Mar;69(3 Pt 2):723-5 [19251017.001]
  • (PMID = 19251016.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Oh K, Redston M, Odze RD: Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. Hum Pathol; 2005 Jan;36(1):101-11
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  • [Title] Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon.
  • This mechanism has also recently been implicated in the newly postulated hyperplastic polyp-serrated adenoma-carcinoma ("serrated") pathway of carcinogenesis, although this has never been investigated thoroughly.
  • The aim of this study was to evaluate hMLH1, hMSH2, MGMT, as well as MIB-1, p53, and beta-catenin immunoexpression in an uncommon cohort of mixed colonic polyps that contain a combination of hyperplastic and adenomatous features (n = 21), and in some (n = 7), carcinoma as well.
  • DESIGN: The clinical, pathological, and immunophenotypic (hMLH1, hMSH2, MGMT, MIB-1, p53, and beta-catenin) properties of 28 mixed hyperplastic and adenomatous polyps of the colon (7 of which also contained carcinoma within the same lesion) were evaluated for the above immunopeptides in each of the different morphologic areas of the polyps, and the results were compared to traditional hyperplastic polyps, serrated adenomas, and conventional (nonserrated) adenomas.
  • RESULTS: Clinically, most mixed polyps with carcinoma occurred in the ascending colon (86%), and pathologically, the adenomatous component of most mixed polyps was serrated (96%).
  • Mixed polyps, particularly those with carcinoma, showed loss of hMLH1 (33%), MGMT (37%), and even hMSH2 (11%) with significantly higher frequency compared to hyperplastic polyps, conventional adenomas, and serrated adenomas.
  • More specifically, loss of hMLH1 and MGMT were more frequent in epithelium of higher neoplastic grade in mixed polyps.
  • However, hMSH2 loss was only present in the adenoma component and never in the hyperplastic or carcinomatous areas of these polyps.
  • Defects in MIB-1 proliferation indices and p53 were not significantly different among the same epithelial components in each of the polyp groups.
  • However, conventional adenomas showed significantly higher rates of nuclear beta -catenin staining (100%) in comparison to the adenomatous component of mixed polyps (60%).
  • [MeSH-major] Cell Transformation, Neoplastic / genetics. Colonic Neoplasms / genetics. Colonic Polyps / genetics. Gene Silencing. Neoplasm Proteins / genetics. O(6)-Methylguanine-DNA Methyltransferase / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Carcinoma / genetics. Carcinoma / metabolism. Carcinoma / pathology. Carrier Proteins. Cytoskeletal Proteins / metabolism. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Female. Humans. Hyperplasia / genetics. Hyperplasia / metabolism. Hyperplasia / pathology. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged. MutS Homolog 2 Protein. Nuclear Proteins. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Trans-Activators / metabolism. Tumor Suppressor Protein p53 / metabolism. beta Catenin

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  • (PMID = 15712188.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / CTNNB1 protein, human; 0 / Carrier Proteins; 0 / Cytoskeletal Proteins; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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20. DaCosta RS, Wilson BC, Marcon NE: Optical techniques for the endoscopic detection of dysplastic colonic lesions. Curr Opin Gastroenterol; 2005 Jan;21(1):70-9
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  • Endoscopic optical coherence tomography has now acquired real-time Doppler capabilities, and rudimentary endoscopic criteria for hyperplastic and adenomatous polyps have been described.

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  • (PMID = 15687888.001).
  • [ISSN] 0267-1379
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromogenic Compounds
  • [Number-of-references] 89
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21. Ihtiyar E, Algin C, Isiksoy S, Ates E: Small cell carcinoma of rectum: a case report. World J Gastroenterol; 2005 May 28;11(20):3156-8
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  • By colonoscopy, polyps were determined in the rectum and biopsies were carried out.
  • Histopathologically, the polyps were adenomatous.

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  • (PMID = 15918209.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4305859
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22. Harford WV: Colorectal cancer screening and surveillance. Surg Oncol Clin N Am; 2006 Jan;15(1):1-20, v
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  • Patients at increased risk for colorectal cancer, such as those with a positive family history, previous adenomatous polyps or cancer, and inflammatory bowel disease, should be offered more intensive evaluation and surveillance.

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  • (PMID = 16389147.001).
  • [ISSN] 1055-3207
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 114
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23. Fernández-Suárez A, Cordero Fernández C, García Lozano R, Pizarro A, Garzón M, Núñez Roldán A: Clinical and ethical implications of genetic counselling in familial adenomatous polyposis. Rev Esp Enferm Dig; 2005 Sep;97(9):654-65
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  • [Title] Clinical and ethical implications of genetic counselling in familial adenomatous polyposis.
  • The association of specific genetic disturbances with the development of hereditary cancer helps us to understand the risk of suffering from it, the possibility of an earlier diagnosis, and the treatment and prevention of this disease.
  • Familial adenomatous polyposis (FAP) is a pre-neoplastic syndrome characterized by the presence of hundreds of adenomatous polyps in the colon, which develop into a carcinoma.
  • FAP can be diagnosed using sequencing techniques to detect mutations in the germinal line of the APC (adenomatous polyposis coli) gene.
  • The genetic diagnostic approach in families with FAP, previously followed up in the Gastrointestinal Clinic, has both advantages and disadvantages, and places us nearer the disease and patient.
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Genetic Counseling


24. Ramos C, De Jesús-Caraballo J, Toro DH, Ojeda A, Martínez-Souss J, Dueño MI, Cruz-Correa M: Is barium enema an adequate diagnostic test for the evaluation of patients with positive fecal occult blood? Bol Asoc Med P R; 2009 Apr-Jun;101(2):23-8
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  • Secondary objectives were to determine: the diagnostic accuracy according to adenoma location, size, and pathologic characteristics; and patient satisfaction with each procedure METHODS: Cross-sectional study comparing the ac curacy of DCBE and colonoscopy in detecting adenomatous polyps and/or colorectal cancer in patients with positive FOBT.
  • Polyps identified during colonoscopy were removed and classified by histology.
  • Polyps were fou in 40/50 (80%) patients in colonoscopy, compared to 19/50 (38%) in DCBE.
  • Eighty-four percent of polyps were missed by DCBE.
  • Diagnostic accuracy of DCBE was inferior to colonoscopy, for all size polyps and larg adenomas.
  • [MeSH-major] Adenocarcinoma / radiography. Adenomatous Polyps / radiography. Barium Sulfate. Colonic Polyps / radiography. Colorectal Neoplasms / radiography. Contrast Media. Enema. Gastrointestinal Hemorrhage / radiography. Occult Blood

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  • (PMID = 19954097.001).
  • [ISSN] 0004-4849
  • [Journal-full-title] Boletín de la Asociación Médica de Puerto Rico
  • [ISO-abbreviation] Bol Asoc Med P R
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Puerto Rico
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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25. Del Rio P, Crafa P, Papadia C, Dell'Abate P, Franzè A, Franzini G, Campanini N, Sianesi M: Evaluation of CD10 positivity in colorectal polyps in neoplastic transformation. Ann Ital Chir; 2010 Mar-Apr;81(2):121-7
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  • [Title] Evaluation of CD10 positivity in colorectal polyps in neoplastic transformation.
  • MATERIALS AND METHOD: We have correlated CD10 positive in carcinomatous polyps with tumour size, grade, patient age and sex, postoperative TNM staging and Asler-Coller classification.
  • We have matched these cases with a control group that showed presence of polypoid adenomatous tissue with mild to moderate dysplasia.
  • RESULTS: We have divided these in a group of 39 cases, characterised by the presence of carcinoma arising in adenomatous polyps, and a control group of 16 cases, characterised by the presence of colorectal polyps with mild to moderate dysplasia.
  • [MeSH-major] Cell Transformation, Neoplastic / metabolism. Colonic Polyps / metabolism. Colonic Polyps / pathology. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Neprilysin / biosynthesis. Rectal Neoplasms / metabolism. Rectal Neoplasms / pathology
  • [MeSH-minor] Aged. Case-Control Studies. Female. Humans. Intestinal Polyps / metabolism. Intestinal Polyps / pathology. Male. Retrospective Studies

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  • (PMID = 20726390.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
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26. Wong DC, Wong SK, Leung AL, Chung CC, Li MK: Combined endolaparoscopic intragastric excision for gastric neoplasms. J Laparoendosc Adv Surg Tech A; 2009 Dec;19(6):765-70
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  • The remaining lesions were adenomatous polyp with focal intramucosal adenocarcinoma, leiomyoma, and pancreatic heterotopia.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Aged, 80 and over. Carcinoma / pathology. Carcinoma / surgery. Cohort Studies. Female. Humans. Leiomyoma / pathology. Leiomyoma / surgery. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 19645605.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Clements D, Tawfiq S, Harries B, Sheridan W: Application of the BSG guidelines to a colonoscopy waiting list. Colorectal Dis; 2009 Jun;11(5):513-5
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  • If applied less rigidly, 42% of patients should not have been on the list.
  • The reasons for removal from the list were as follows: Thirty-nine patients were older than the upper age limit, 23 had had clear colonoscopies after adenomatous polyp follow up, four were listed for diverticular disease follow up, four for metaplastic polyps, one for constipation and one for per rectum (PR) bleed follow up.
  • Conclusion With strict application of the BSG guidelines to a surveillance colonoscopy waiting list, 49% of the patients on the list do not need the procedure.

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  • (PMID = 18637926.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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28. Goode EL, Potter JD, Bamlet WR, Rider DN, Bigler J: Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. Carcinogenesis; 2007 Feb;28(2):328-41
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  • [Title] Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps.
  • Exposures such as cigarette smoke and meat contain a variety of procarcinogens, which are thought to play a role in elevation of risk for colorectal polyps and/or cancer.
  • We hypothesized that genetic variation in the encoding genes NAT1, NAT2, SULT1A1, SULT1A2, CYP1A1 or EPHX1 is associated with risk of colorectal polyps and interacts with cigarette use or meat intake to modify risk of colorectal polyps.
  • We examined the role of these genes in a clinic-based study of 651 Caucasian cases with hyperplastic polyps, adenomatous polyps or both types of polyps and 556 polyp-free controls.
  • We found evidence for interaction between NAT acetylator status and SULT1A1 genotype in risk of hyperplastic polyps: individuals with SULT1A1 638AA genotype and NAT1 and NAT2 intermediate/fast phenotypes had 3.5-fold increased risk (95% CI 1.2-10.3) compared with individuals with SULT1A1 638GG genotype and NAT1 and NAT2 slow phenotypes.
  • [MeSH-major] Carcinogens / metabolism. Colonic Polyps / enzymology. Enzymes / metabolism. Genetic Variation
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Genetic Predisposition to Disease. Humans. Middle Aged. Risk Factors

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  • (PMID = 16926176.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R25-CA094880; United States / NCI NIH HHS / CA / T32-CA09661
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Enzymes
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29. Chia VM, Newcomb PA, Lampe JW, White E, Mandelson MT, McTiernan A, Potter JD: Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev; 2007 Dec;16(12):2697-703
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  • [Title] Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk.
  • Obesity has been shown to be associated with an increased risk of both colorectal cancer and adenomatous polyps.
  • We conducted a gastroenterology clinic-based, case-control study to evaluate the relationship between circulating leptin concentrations and colorectal adenoma risk; in addition, we evaluated the relationship between leptin receptor polymorphisms and adenoma risk.
  • Among men, those in the highest tertile of leptin concentrations had a 3.3-fold (95% confidence interval, 1.2-8.7) increased adenoma risk compared with those in the lowest tertile (P trend = 0.01).
  • There were no associations between leptin concentrations and adenoma risk in women.
  • There were no associations of leptin receptor genotypes or haplotypes and adenoma risk.

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  • (PMID = 18086776.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01CA74184; United States / NCI NIH HHS / CA / R03 CA110852; United States / NCI NIH HHS / CA / R25 CA094880; United States / NCI NIH HHS / CA / U01 CA074794; United States / NCI NIH HHS / CA / P01 CA074184; United States / NCI NIH HHS / CA / R25CA094880; United States / NCI NIH HHS / CA / R03CA11085
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leptin; 0 / Receptors, Leptin
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30. Groblewska M, Mroczko B, Wereszczyńska-Siemiatkowska U, Kedra B, Lukaszewicz M, Baniukiewicz A, Szmitkowski M: Serum interleukin 6 (IL-6) and C-reactive protein (CRP) levels in colorectal adenoma and cancer patients. Clin Chem Lab Med; 2008;46(10):1423-8
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  • [Title] Serum interleukin 6 (IL-6) and C-reactive protein (CRP) levels in colorectal adenoma and cancer patients.
  • It has been shown that local chronic inflammation may lead to colorectal carcinogenesis via adenomatous polyps.
  • METHODS: Serum levels of interleukin-6, carcinoembryonic antigen and carbohydrate antigen 19-9 were determined using immunoenzymatic assays, and C-reactive protein concentrations by immunoturbidimetric kits in 76 colorectal cancer patients before surgery, in 38 colorectal adenoma patients and in 35 healthy controls.
  • RESULTS: Serum levels of interleukin-6, C-reactive protein and carcinoembryonic antigen were significantly higher in cancer patients when compared to adenoma patients and healthy subjects, and increased in more advanced stages of disease and in patients with non-resectable tumors.


31. Beaton MD, Taylor B, Driman D, Ainsworth P, Adams PC: Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation? Can J Gastroenterol; 2008 Jul;22(7):634-6
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  • [Title] Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation?
  • Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps.
  • While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colonic Polyps / pathology

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  • (PMID = 18629394.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
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  • [Other-IDs] NLM/ PMC2661270
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32. Halligan S, Taylor SA: CT colonography: results and limitations. Eur J Radiol; 2007 Mar;61(3):400-8
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  • Meta-analysis of data from studies of CT colonography suggests that it has excellent per-patient average sensitivity and average specificity for detection of adenomatous polyps and cancer.
  • [MeSH-major] Adenoma / radiography. Colonic Polyps / radiography. Colonography, Computed Tomographic. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / prevention & control

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  • (PMID = 17174055.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] Ireland
  • [Number-of-references] 35
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33. Wasilewicz MP, Kołodziej B, Bojułko T, Kaczmarczyk M, Sulzyc-Bielicka V, Bielicki D, Ciepiela K: Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis. Int J Colorectal Dis; 2010 Sep;25(9):1079-85
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  • METHODS: A total of 111 patients were examined and 120 histologically different colonic adenomas analyzed (including four cases of intramucosal adenocarcinoma in a polyp).
  • RESULTS: There was a significant correlation between high 5-LOX expression and patient age, increased polyp size, high grade of intraepithelial neoplasia, villous and tubulovillous adenoma, and histological epithelial localization.
  • CONCLUSIONS: We observed a strong positive correlation between 5-LOX overexpression and the appearance of typical high-risk factors for malignant transformation in adenomatous polyps.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Arachidonate 5-Lipoxygenase / metabolism. Colonic Neoplasms / enzymology. Colonic Neoplasms / pathology. Precancerous Conditions / enzymology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma in Situ / enzymology. Carcinoma in Situ / pathology. Colonic Polyps / enzymology. Colonic Polyps / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 20549218.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
  • [Other-IDs] NLM/ PMC2912725
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34. Kim JH, Lee SY, Kim BK, Choe WH, Kwon SY, Sung IK, Park HS, Jin CJ: Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy. World J Gastroenterol; 2008 Mar 28;14(12):1903-7
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  • [Title] Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy.
  • AIM: To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy.
  • METHODS: Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision.
  • Both pre- and post-sprayed images were shown to 16 examiners, who were asked to interpret the lesions as either hyperplastic or adenomatous polyps.
  • Regression analysis demonstrated that surrounding colonic mucosa was the only factor that was significantly related to accuracy in discriminating adenomatous from hyperplastic polyps (P < 0.001).
  • Accuracy was higher for polyps with linear surrounding colonic mucosa than for those with nodular surrounding colonic mucosa (P < 0.001), but was not related to the shape, location, or size of the polyp.
  • CONCLUSION: The accuracy of predicting histology is significantly related to the pattern of colonic mucosa surrounding the polyp.
  • Making a histological diagnosis of colon polyps merely by acetic acid spray is helpful for colon polyps with linear, regularly patterned surrounding colonic mucosa, and less so for those with nodular, irregularly patterned surrounding colonic mucosa.
  • [MeSH-major] Acetic Acid. Adenomatous Polyps. Colonic Polyps. Endoscopy / methods. Hyperplasia. Intestinal Mucosa

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  • (PMID = 18350630.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] Q40Q9N063P / Acetic Acid
  • [Other-IDs] NLM/ PMC2700415
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35. Half EE, Arber N: Chemoprevention of colorectal cancer: two steps forward, one step back? Future Oncol; 2006 Dec;2(6):697-704
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  • The poor survival rate has prompted the emphasis on prevention of this disease.
  • Sulindac and celecoxib were shown to be effective in promoting polyp regression in high-risk individuals with familial adenomatous polyposis.
  • In the more common sporadic setting, the Adenomatous Polyp PRevention On Vioxx (rofecoxib), Adenoma Prevention with Celecoxib and Prevention of Sporadic Adenomatous Polyps (celecoxib) trials have demonstrated a significant reduction in adenoma recurrence, but important concerns were raised regarding cardiovascular toxicity associated with selective cyclo-oxygenase-2 inhibitors.
  • Currently, the only approved agent for chemoprevention is celecoxib in high-risk individuals with familial adenomatous polyposis.
  • [MeSH-major] Adenoma / prevention & control. Adenomatous Polyps / drug therapy. Anticarcinogenic Agents / therapeutic use. Colonic Polyps / drug therapy. Colorectal Neoplasms / prevention & control

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  • (PMID = 17155896.001).
  • [ISSN] 1479-6694
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 0 / Cyclooxygenase 2 Inhibitors
  • [Number-of-references] 59
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36. Erdem L, Akbayir N, Yildirim S, Köksal HM, Yenice N, Gültekin OS, Sakiz D, Peker O: Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon. Turk J Gastroenterol; 2005 Dec;16(4):207-11
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  • [Title] Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon.
  • The necessity of colonoscopy in patients with an adenoma of<or=5 mm found on sigmoidoscopy is controversial.
  • METHODS: Patients found to have rectosigmoid adenomatous polyps on colonoscopy were included in the study.
  • These adenomas were grouped as diminutive (<or=5 mm), small (6-10 mm) or large (>or=11 mm) polyps.
  • These groups were compared regarding the presence of proximal adenoma and advanced proximal neoplasia (>10 mm adenoma and/or villous histology and/or high grade dysplasia or cancer).
  • Polyps found in the rectum and sigmoid colon were considered as distal polyps and polyps other than these were considered as proximal polyps.
  • RESULTS: In this study, of 1124 consecutive patients who underwent colonoscopy between April 1997 and January 2002, 184 (16%) had 258 adenomatous polyps in the rectosigmoid area.
  • The polyps were diminutive (<or=5 mm) in 105, small (6-10 mm) in 46 and large (>or=11 mm) in 33 patients.
  • Forty-one of the patients (39%) with diminutive polyps, 20 of the patients (43%) with small polyps and 19 of the patients (57%) with large polyps had neoplasm in the proximal bowel.
  • The rate of advanced proximal neoplasm was found to be significantly higher in the group with large polyps in the rectosigmoid area than in the groups with small and diminutive polyps (p<0.05).
  • In 104 patients (57%) with polyp(s) in rectum and sigmoid colon, no associated polyp or cancer was encountered in the proximal colon.
  • CONCLUSION: Colonoscopy is indicated when adenomatous polyp, regardless of size, is found on rectosigmoidoscopy performed because of symptoms.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neoplasms, Multiple Primary. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 16547849.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Turkey
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37. Pino MS, Mino-Kenudson M, Wildemore BM, Ganguly A, Batten J, Sperduti I, Iafrate AJ, Chung DC: Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. J Mol Diagn; 2009 May;11(3):238-47
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  • The combination of MSI and IHC testing in colorectal adenomas is a sensitive screen for the detection of Lynch syndrome and may be particularly useful when Lynch syndrome is suspected and adenomatous polyps are the only tissues available for analysis.

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  • (PMID = 19324997.001).
  • [ISSN] 1943-7811
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA092594; United States / NCI NIH HHS / CA / CA92594
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2671341
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38. Khatibzadeh N, Ziaee SA, Rahbar N, Molanie S, Arefian L, Fanaie SA: The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps. J Cancer Res Ther; 2005 Oct-Dec;1(4):204-7
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  • [Title] The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps.
  • BACKGROUND: The appropriate application of Endoscopic modalities for polypectomy depends on the likelihood that the adenoma in question harbors invasive cancer.
  • While prior studies have evaluated polyp size and morphology in assessing the risk of malignancy, in recent decay some authorities have paid more attention to dysplasia.
  • All in all, the relative risk of cancer based on polyp distribution in correlation with dysplasia has not been statistically studied which is done in our study.
  • METHODS AND MATERIALS: Between June 2001 and March 2004, the distribution of 130 adenomatous polyps was compared with synchronous invasive or in situ cancer.
  • Factors such as Patient age, Patients gender, location of lesion, size of polyp, histological subtype of adenoma on biopsy, degree of dysplasia, synchronous cancer, color of polyp, and number of polyps were included in the data collection.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17998654.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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39. Paskett ED, Reeves KW, Pineau B, Albert PS, Caan B, Hasson M, Iber F, Kikendall JW, Lance P, Shike M, Slattery ML, Weissfeld J, Kahle L, Schatzkin A, Lanza E, Polyp Prevention Trial Study Group: The association between cigarette smoking and colorectal polyp recurrence (United States). Cancer Causes Control; 2005 Nov;16(9):1021-33
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  • [Title] The association between cigarette smoking and colorectal polyp recurrence (United States).
  • OBJECTIVE: Although evidence exists linking smoking to precancerous colorectal adenomatous polyps, few studies have examined the association between cigarette smoking and recurrence of colorectal polyps.
  • This association was investigated prospectively with data from the Polyp Prevention Trial.
  • Multiple logistic regression analysis was used to examine the association between cigarette smoking and polyp recurrence (adenomatous and hyperplastic) up to four years from baseline.
  • RESULTS: Adenoma recurrence was not related to cigarette smoking.
  • Current smokers had increased odds of hyperplastic polyps at follow-up compared to never smokers (OR 2.88, 95% CI 2.06-4.01).
  • Current smoking was associated with subsequent distal (OR 3.44, 95% CI 2.38-4.95) and rectal (OR 3.53, 95% CI 2.15-5.78) hyperplastic polyps, but not subsequent proximal hyperplastic polyps.
  • Cigarette smoking was associated with subsequent multiple and small size (4 mm) hyperplastic polyps.
  • Significant linear trends were observed between development of subsequent hyperplastic polyps and all smoking variables.
  • CONCLUSIONS: Although no association with recurrent adenomas was observed, cigarette smoking was significantly associated with hyperplastic polyp development, except for those in the proximal colon.
  • This prospective study confirms that cigarette smoking has a significant effect on the development of hyperplastic colorectal polyps.
  • [MeSH-major] Colonic Polyps / pathology. Precancerous Conditions. Smoking / epidemiology
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / pathology. Aged. Colonoscopy. Epidemiologic Studies. Female. Humans. Hyperplasia / epidemiology. Hyperplasia / pathology. Male. Middle Aged. Recurrence. Risk Assessment. Risk Factors. Surveys and Questionnaires. Time Factors. United States

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  • (PMID = 16184467.001).
  • [ISSN] 0957-5243
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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40. Casadesus D: Surgical resection of rectal adenoma: a rapid review. World J Gastroenterol; 2009 Aug 21;15(31):3851-4
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  • [Title] Surgical resection of rectal adenoma: a rapid review.
  • Transanal excision (TE), endoscopic transanal resection (ETAR) and transanal endoscopic microsurgery (TEM) can be used to remove adenomatous polyps.
  • [MeSH-major] Adenoma. Anastomosis, Surgical. Rectal Neoplasms

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  • (PMID = 19701964.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 41
  • [Other-IDs] NLM/ PMC2731246
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41. Oh SY, Park DI, Yoo TW, Kang MS, Kim SH, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Son BH, Yoo CH: [Is gastric cancer a new indication for surveillance colonoscopy? Colon cancer is increased in gastric cancer patients]. Korean J Gastroenterol; 2006 Mar;47(3):191-7
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  • BACKGROUND/AIMS: It has been reported that the risk of gastric polyp is increased in various colonic polyposis syndromes or in series of patients with sporadic colonic polyps.
  • RESULTS: In the patient group, adenomatous polyps were diagnosed in 24/105 patients (22.9%) and colorectal adenocarcinoma in 10/105 patients (9.5%).
  • In the control group, adenomatous polyps were diagnosed in 78/269 patients (29.0%) and colorectal adenocarcinoma in 2/269 patients (0.7%).
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Female. Humans. Male. Middle Aged

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  • (PMID = 16554672.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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42. Hao CY, Moore DH, Wong P, Bennington JL, Lee NM, Chen LC: Alteration of gene expression in macroscopically normal colonic mucosa from individuals with a family history of sporadic colon cancer. Clin Cancer Res; 2005 Feb 15;11(4):1400-7
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  • To determine whether these alterations also occur in the MNCM of individuals who have not developed colon cancer but are at high risk of doing so, we measured gene expression in the MNCM of individuals with a family history of colon cancer.
  • CONCLUSIONS: Molecular abnormalities that precede the appearance of adenomatous polyp are present in the MNCM of individuals who have a family history of colon cancer.
  • To assess this possibility, prospective studies will be needed to determine whether or not altered gene expression is associated with the subsequent development of adenomatous polyps and/ or colonic carcinomas.

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  • (PMID = 15746039.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-8; 0 / Membrane Proteins; 0 / PPAR delta; 0 / PPAR gamma; 0 / Serum Amyloid A Protein; 63231-63-0 / RNA; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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43. Galimov OV, Rylova TV, Khanov VO: [Endoscopy in the diagnosis and treatment of gastric polyps]. Vestn Khir Im I I Grek; 2008;167(5):65-7
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  • [Title] [Endoscopy in the diagnosis and treatment of gastric polyps].
  • The authors present a clinico-statistical analysis of results of endoscopic polypectomy and dynamic observation of 258 patients with gastric polyps.
  • The aim of the investigation was to determine a true histological diagnosis of gastric polyps using excisional biopsy.
  • An endoscopic investigation has revealed 475 polyps in the stomach of 258 patients.
  • Endoscopic polypectomy by the method of electroexcision and preliminary submucous administration of solutions was used for 218 polyps having the size more than 0.5 cm.
  • Patients with formations located submucously and malignant tumors of the stomach (polypoid cancers included) were not investigated.
  • Metaplastic and dysplastic alterations characteristic of adenomatous polyps were detected by the method of chromoscopy.
  • [MeSH-major] Gastroscopy / methods. Polyps / pathology. Polyps / surgery. Stomach Diseases / pathology. Stomach Diseases / surgery

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  • (PMID = 19069827.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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44. McLaren CE, Fujikawa-Brooks S, Chen WP, Gillen DL, Pelot D, Gerner EW, Meyskens FL Jr: Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas. Cancer Prev Res (Phila); 2008 Dec;1(7):514-21
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  • A phase III clinical trial assessed the recurrence of adenomatous polyps after treatment for 36 months with difluoromethylornithine (DFMO) plus sulindac or matched placebos.
  • Dose intensity did not add information to models.

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  • (PMID = 19139001.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA059024; United States / NCI NIH HHS / CA / R01 CA088078-05; United States / NCI NIH HHS / CA / P30 CA023074; None / None / / R01 CA059024-04; United States / NCI NIH HHS / CA / P30 CA062203-13; United States / NCI NIH HHS / CA / R01 CA059024-04; United States / NCI NIH HHS / CA / CA 23074; United States / NCI NIH HHS / CN / N01 CN 75019; United States / NCI NIH HHS / CA / CA 95060; United States / NCI NIH HHS / CN / N01 CN075019; United States / NCI NIH HHS / CA / P50 CA095060-07; United States / NCI NIH HHS / CA / CA 88078; United States / NCI NIH HHS / CA / P50 CA095060; United States / NCI NIH HHS / CA / CA 59024; United States / NCI NIH HHS / CA / CA095060-07; United States / NCI NIH HHS / CA / P30 CA062203; United States / NCI NIH HHS / CA / R01 CA088078; United States / NCI NIH HHS / CN / N01 CN085182; United States / NCI NIH HHS / CA / CA088078-05; United States / NCI NIH HHS / CA / R01 CA063640; United States / NCI NIH HHS / CA / CA062203-13
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 184SNS8VUH / Sulindac; ZQN1G5V6SR / Eflornithine
  • [Other-IDs] NLM/ NIHMS91693; NLM/ PMC2702261
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45. Pérez R, Lasa A, Toro DH, Cruz-Correa M, Martinez-Souss J: Relationship between sporadic hyperplastic polyps and colorectal neoplasia in Hispanic veterans. P R Health Sci J; 2010 Dec;29(4):372-6
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  • [Title] Relationship between sporadic hyperplastic polyps and colorectal neoplasia in Hispanic veterans.
  • OBJECTIVE: Hyperplastic polyps (HP) traditionally have been regarded as having no malignant potential.
  • Some studies have suggested that HP in the distal colon may predict presence of adenomatous polyps in the proximal colon.
  • METHODS: The study consisted of a retrospective review of all the medical records of patients who underwent a colonoscopy for the first time during the calendar year 2005 and had a pathologic diagnosis of HP, tubular adenoma (TA), tubulovillous adenoma (TVA), villous adenoma (VA) and/or colon adenocarcinoma at the VA Caribbean Healthcare System.
  • CONCLUSION: The present study suggests that the presence of HP is not associated with CRN in our veteran population.
  • The results of this study support current colon cancer guidelines in which surveillance for HP is not recommended.
  • [MeSH-major] Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Hispanic Americans


46. Pranesh N, Haboubi NY, O'Dwyer ST: Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch. Ann R Coll Surg Engl; 2005 Jul;87(4):W1-4
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  • [Title] Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch.
  • Familial adenomatous polyposis (FAP) is an autosomal dominant condition with near complete penetrance, characterised by the presence of numerous adenomatous polyps of the colon and rectum.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Lymphatic Diseases / complications. Melanosis / complications. Mesentery. Peritoneal Diseases / complications


47. Health Quality Ontario: Fecal occult blood test for colorectal cancer screening: an evidence-based analysis. Ont Health Technol Assess Ser; 2009;9(10):1-40
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  • Specifically: Is the use of gFOBT or iFOBT associated with a reduction in CRC and overall mortality?What are the sensitivity and specificity of gFOBT and iFOBT for the detection of 1) CRC and 2) large polyps (≥ 1 cm)?
  • It has been estimated that in 2007, 7,800 people were diagnosed with CRC in Ontario and 3,250 died from the disease, making the province's incidence and mortality rate of CRC amongst the highest in the world.
  • Blood in the stool is a nonspecific finding but may originate from CRC or larger (>1 cm) polyps (small adenomatous polyps do not tend to bleed).
  • Bleeding from cancers and larger polyps may be intermittent and not always detectable in a single sample.
  • INCLUSION CRITERIA: Patients at average risk for CRCAll patients must be at least 50 years of ageBiennial FOBT as a screening modality and use of colonoscopy as the reference standardSystematic reviews and randomized controlled trials (RCTs) OUTCOMES: CRC mortality, overall mortality, sensitivity, specificity, adverse effects EXCLUSION CRITERIA: Studies involving fewer than 100 patientsStudies that do not report sufficient data for analysis COMPARISONS OF INTEREST: Evidence exists for these comparisons of interest: gFOBT compared with the reference "gold standard" colonoscopy (or double-contrast barium enema where colonoscopy is incomplete or contraindicated)iFOBT compared with the reference gold standard colonoscopy (or DCBE where colonoscopy is incomplete or contraindicated)gFOBT compared with iFOBTThe quality of the diagnostic studies was examined according to the 'GRADE Working Group criteria' for grading quality of evidence and strength of recommendations for diagnostic tests and strategies.
  • SUMMARY OF FINDINGS: SINGLE-TEST STUDIES: There is limited direct/indirect evidence that iFOBT has sensitivity/specificity superior to that of unrehydrated gFOBT for CRC detection: sensitivity for gFOBT:13% and 25%pooled iFOBT sensitivity:81%There is evidence that iFOBT and gFOBT have lower sensitivities for adenoma detection than for CRC detection: sensitivity for rehydrated gFOBT22%pooled iFOBT sensitivity28% REPEATED-TEST STUDIES: No trials have examined CRC mortality outcomes after repeated testing of iFOBT.
  • true positive rate50% (United Kingdom and Danish RCTs)false positive rate5%-10%true negative rate90%-95% (from observational studies as RCTs did not report specificity)false negative rate50%ES Table 1:Guaiac FOBT - GRADE Quality of Evidence for InterventionsOutcomeDesignQualityConsistencyDirectnessOverall QualityCRCMortalityRCTDanishN = 137,485United KingdomN = 152,850No seriouslimitationsYes (RR reduction in 2 trials13% and 16%; absolutedifference 0.1% and 0.2%respectively).Age rangeDanish and UnitedKingdom study 45-75yearsHighCRC indicates colorectal cancer; FOBT, fecal occult blood test; GRADE, Grading of Recommendations Assessment, Development and Evaluation; RCT, randomized controlled trial.

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  • (PMID = 23074514.001).
  • [ISSN] 1915-7398
  • [Journal-full-title] Ontario health technology assessment series
  • [ISO-abbreviation] Ont Health Technol Assess Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3377532
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48. Hartmann D, Bassler B, Schilling D, Adamek HE, Jakobs R, Pfeifer B, Eickhoff A, Zindel C, Riemann JF, Layer G: Colorectal polyps: detection with dark-lumen MR colonography versus conventional colonoscopy. Radiology; 2006 Jan;238(1):143-9
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  • [Title] Colorectal polyps: detection with dark-lumen MR colonography versus conventional colonoscopy.
  • PURPOSE: To prospectively compare dark-lumen magnetic resonance (MR) colonography with conventional colonoscopy in the detection of colorectal polyps.
  • Results of MR colonography were analyzed on a per-polyp and per-patient basis.
  • In the other 49 patients (53%), conventional colonoscopy depicted 107 polyps (82 adenomas, 25 hyperplastic polyps) and seven carcinomas.
  • At per-polyp analysis, sensitivity of MR colonography in the detection of adenomatous polyps was 100% for polyps at least 10 mm in diameter and 84.2% for polyps 6-9 mm in diameter.
  • At per-patient analysis, the accuracy of MR colonography was 93.1% (sensitivity, 89%; specificity, 96%) if detection of adenomatous polyps of all sizes was considered.
  • CONCLUSION: Dark-lumen MR colonography is a promising modality with high accuracy for detecting colorectal polyps larger than 5 mm in diameter.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonoscopy. Magnetic Resonance Imaging / methods

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  • [Copyright] RSNA, 2005.
  • (PMID = 16304088.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine
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49. Döbrôssy L, Kovács A, Budai A, Cornides A, Ottó S, Tulassay Z: [The state of the colorectal screening in Hungary: lessons of the pilot programs]. Orv Hetil; 2007 Sep 23;148(38):1787-93
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  • In Hungary, colorectal cancer is the second most common malignant disease.
  • The compliance was not more than 30-45%.
  • The programmes revealed a great number of adenomatous polyps and early cancers, and in the way, the effectiveness of the method has been proved.


50. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL: Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol; 2009 Sep 16;9:67
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  • BB increased (P < 0.05) ACF numbers within the distal colon of female but not male rats.
  • There was a tendency (0.1 > P > 0.05) for fewer adenocarcinomas (relative to total of adenomatous polyps plus adenocarcinomas) in colons of female than male tumor-bearing rats; in small intestine, this gender difference was significant (P < 0.05).
  • BB favored (P < 0.05) fewer adenocarcinomas and more adenomatous polyps (as a proportion of total tumor number) in female rat small intestine.
  • CONCLUSION: Results did not indicate robust cancer-preventive effects of BB.
  • Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB.

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  • (PMID = 19758446.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CB / N02-CB-07008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C-Peptide; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ PMC2752457
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51. Kaczka A, Kumor A, Pietruczuk M, Małecka-Panas E: [Serum concentration of insulin, C-peptide and insulin-like growth factor I in patients with colon adenomas and colorectal cancer]. Pol Merkur Lekarski; 2007 May;22(131):373-5
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  • In patients with colon adenomatous polyps we also observed higher serum IGF-I concentrations I comparing to the control group (82.1 ng/ml vs. 60.96 ng/ml), in high dysplasia adenomas (84.12 ng/ml vs. 79.67 ng/ml) and in smaller adenomas to 1 cm diameter (97.98 ng/ml vs. 73.28 ng/ml), but the differences were not significant.
  • We also observed higher concentration of C-peptide in patients with low grade dysplasia adenomas (665.24 pmol/l vs. 498.13 pmol/l) and with small polyps (611.51 pmol/l vs. 514.89 pmol/l).
  • [MeSH-major] Adenoma / blood. Adenomatous Polyps / blood. C-Peptide / blood. Colonic Polyps / blood. Colorectal Neoplasms / blood. Insulin / blood

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  • (PMID = 17679371.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / C-Peptide; 0 / Insulin; 67763-96-6 / Insulin-Like Growth Factor I
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52. Sato Y, Nozaki R, Yamada K, Takano M, Haruma K: Relation between obesity and adenomatous polyps of the large bowel. Dig Endosc; 2009 Jul;21(3):154-7
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  • [Title] Relation between obesity and adenomatous polyps of the large bowel.
  • BACKGROUND: We compared the prevalence of colorectal adenoma (polyps) in men and women and examined the role of body mass index (BMI) on polyp risk according to patient age and gender.
  • METHODS: The risk of developing colorectal polyps was studied in 15 380 subjects (7155 men and 8225 women) who underwent colonoscopy for the first time from April 1998 to March 2006 at our 'Human Dry Dock', which is the check-up service provided in Japan.
  • Eligible subjects were 20-86 years old (mean age +/- SD, 47.3 +/- 8.5) and were free of invasive cancer, hyperplastic polyps and familial polyposis.
  • Polyps were found in 1590 subjects (1062 men and 528 women).
  • The odds ratio (OR) of detection of polyps in relation to obesity was determined in all cases by multivariate logistic regression analysis after making an adjustment for gender and age.
  • RESULTS: The OR of polyp detection in obese subjects (BMI >or= 25) versus non-obese subjects (BMI < 25, OR = 1) was 1.34 (P < 0.001) in men and 1.13 (P = 0.26) in women.
  • CONCLUSIONS: We conclude that obesity in men is a risk factor for the development of polyps.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology

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  • (PMID = 19691761.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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53. Ozsunar Y, Coskun G, Delibaş N, Uz B, Yükselen V: Diagnostic accuracy and tolerability of contrast enhanced CT colonoscopy in symptomatic patients with increased risk for colorectal cancer. Eur J Radiol; 2009 Sep;71(3):513-8
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  • Two masses and eight polyps, consisted of 1 tubulovillous, 1 tubular, 2 villous adenoma, 4 adenomatous polyp, 4 adenocarcinoma, were identified.

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  • (PMID = 18597964.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
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54. Kim BJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC, Choe YH, Choi YH, Shim SG, Kim YH: Coexistence between carotid artery stenosis and colorectal adenomatous polyps in middle-aged men. Digestion; 2010;81(1):20-6
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  • [Title] Coexistence between carotid artery stenosis and colorectal adenomatous polyps in middle-aged men.
  • BACKGROUND: Colorectal neoplasia and cardiovascular disease appear to share common risk factors.
  • RESULTS: The prevalence of overall colorectal adenomatous polyps (APs) was 31.4% (591/1,877).
  • [MeSH-major] Adenomatous Polyps / complications. Carotid Stenosis / complications. Colorectal Neoplasms / complications

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] Digestion. 2010;81(1):18-9 [20029205.001]
  • [CommentIn] Digestion. 2010;81(1):16-7 [20029204.001]
  • (PMID = 20051688.001).
  • [ISSN] 1421-9867
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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55. Yeruham I, Perl S, Lahav D: Anal adenomatous polyps in a crossbred beef cow. Vet Rec; 2005 Aug 13;157(7):204
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  • [Title] Anal adenomatous polyps in a crossbred beef cow.
  • [MeSH-major] Adenomatous Polyps / veterinary. Anus Neoplasms / veterinary. Cattle Diseases / pathology

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  • (PMID = 16100372.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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56. Martayan A, Sanchez-Mete L, Baldelli R, Falvo E, Barnabei A, Conti L, Giacomini P, Appetecchia M, Stigliano V: Gene variants associated to malignant thyroid disease in familial adenomatous polyposis: a novel APC germline mutation. J Endocrinol Invest; 2010 Oct;33(9):603-6
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  • [Title] Gene variants associated to malignant thyroid disease in familial adenomatous polyposis: a novel APC germline mutation.
  • BACKGROUND AND AIM: Familial adenomatous polyposis (FAP) is an autosomal inherited syndrome characterized by hundreds to thousands colorectal adenomatous polyps with oncological transformation lifetime risk of 100%.
  • The aim of this study was to evaluate the frequency of PTC among our series of FAP patients and to assess the type of gene mutation associated with the disease.
  • RESULTS: In 13/54 (24.1%) subjects, an eumetabolic thyroid disease was found: plurinodular disease in 7/54 (13.0%); single nodule in 4/54 (7.4%); in 2/54 patients (3.7%), we found a malignant nodule characterized after total thyroidectomy as a classical PTC.
  • Both patients had classic FAP phenotype and genetic analysis revealed two pathogenetic APC mutations: c.3183_87delACAAA, a recurrent pathogenetic variant and del9-10 (del9080dup11), a novel, not previously described genomic rearrangement.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Carcinoma, Papillary / genetics. Genes, APC. Germ-Line Mutation. Thyroid Neoplasms / genetics


57. Puppa G, Colombari R: Brown colon (melanosis coli) harbouring pale tumors (adenocarcinoma and an adenomatous polyp). J Gastrointestin Liver Dis; 2009 Dec;18(4):509-11
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  • [Title] Brown colon (melanosis coli) harbouring pale tumors (adenocarcinoma and an adenomatous polyp).
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyps / pathology. Colonic Diseases / pathology. Colonic Neoplasms / pathology. Melanosis / pathology

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  • (PMID = 20076832.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Romania
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58. Yee J, Rosen MP, Blake MA, Baker ME, Cash BD, Fidler JL, Grant TH, Greene FL, Jones B, Katz DS, Lalani T, Miller FH, Small WC, Sudakoff GS, Warshauer DM: ACR Appropriateness Criteria on colorectal cancer screening. J Am Coll Radiol; 2010 Sep;7(9):670-8
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  • This malignancy is ideally suited for screening because the detection and removal of the precursor adenomatous polyp can prevent most colorectal cancers from ever forming.
  • The double-contrast barium enema is an alternative imaging test that is appropriate particularly when CTC is not available.
  • Imaging tests including CTC and the double-contrast barium enema are usually not indicated for colorectal cancer screening in high-risk patients with polyposis syndromes or inflammatory bowel disease.
  • [MeSH-minor] Adenoma / complications. Biopsy. Colitis, Ulcerative / radiography. Colonography, Computed Tomographic / methods. Colonoscopy / statistics & numerical data. Crohn Disease / radiography. Humans. Risk Assessment. Survival Rate. Tomography, X-Ray Computed / methods. United States / epidemiology


59. Bafandeh Y, Khoshbaten M, Eftekhar Sadat AT, Farhang S: Clinical predictors of colorectal polyps and carcinoma in a low prevalence region: results of a colonoscopy based study. World J Gastroenterol; 2008 Mar 14;14(10):1534-8
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  • [Title] Clinical predictors of colorectal polyps and carcinoma in a low prevalence region: results of a colonoscopy based study.
  • Adenomatous polyps were detected in 56 (11.7%) patients, in 12.3% of men and 10.9% of women.
  • The mean age of the patients with a polyp was significantly higher than the others (49.53 +/- 14.16 vs 41.85 +/- 16.26, P = 0.001).
  • Most of the adenomatous polyps were left sided and tubular; only 22.5% of polyps were more than 10 mm.
  • The mean age of patients with cancer was significantly higher than the others (60.25 +/- 8.26 vs 42.13 +/- 16.08, P < 0.005) and higher than patients with polyps [60.25 (8.26) vs 49.53 (1.91) (P < 0.0005)].
  • None of the symptoms (diarrhea, abdominal pain, rectal bleeding, constipation, altering diarrhea and constipation, history of cancer, known irritable bowel disease, history of polyp and fissure or family history of cancer) were predictors for cancer or polyps, but the age of the patient and unexplained anemia independently predicted cancer.
  • Colonic symptoms are not predictors for polyps or cancer but unexplained anemia and elder age can predict CRC.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / epidemiology. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology

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  • (PMID = 18330943.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2693747
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60. Castillo-Alcala F, Mans C, Bos AS, Taylor WM, Smith DA: Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo). Can Vet J; 2010 Nov;51(11):1261-4
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  • [Title] Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo).
  • The histopathological diagnosis of the resected mass was an adenomatous polyp of the colon.
  • [MeSH-major] Adenomatous Polyps / veterinary. Colonic Polyps / veterinary. Ferrets

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  • [Cites] J Am Anim Hosp Assoc. 1997 Mar-Apr;33(2):156-60 [9111726.001]
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  • (PMID = 21286327.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal = La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2957035
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61. Rutter MD: Are adenomatous polyps rare in ulcerative colitis? Aliment Pharmacol Ther; 2005 Jan 1;21(1):98-9; author reply 99-100
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  • [Title] Are adenomatous polyps rare in ulcerative colitis?
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Colitis, Ulcerative / complications

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  • [CommentOn] Aliment Pharmacol Ther. 2004 Apr 15;19(8):879-87 [15080849.001]
  • (PMID = 15644053.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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62. Farah-Klibi F, Kourda-Boujemaa J, Bouaskar I, Dziri C, Rachida Z, Jilani-Baltagi SB: Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature. Pathologica; 2009 Dec;101(6):255-60
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  • [Title] Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature.
  • CASE PRESENTATION: A mucocele of the appendix, due to mucinous cystadenocarcinoma, was documented as an incidental perioperatory finding in a 68-year-old female.
  • Degenerated adenomatous polyp of the ascending colon and mucinous adenocarcinoma of the sigmoid colon invading the parietal peritoneum of the uterine and vagina was diagnosed.

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  • (PMID = 20387715.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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63. Akyürek N, Salman B, Irkörücü O, Sare M, Tatlicioğlu E: Ultrasonography in the diagnosis of true gallbladder polyps: the contradiction in the literature. HPB (Oxford); 2005;7(2):155-8
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  • [Title] Ultrasonography in the diagnosis of true gallbladder polyps: the contradiction in the literature.
  • Polypoid lesions of the gallbladder (PLGs) are often incidentally identified during ultrasonographic examination of abdominal pain.
  • Data were collected regarding the patients' gender, age, symptoms, serum lipid levels, the size and the number of polyps on US, surgical indications for PLGs and histopathological diagnosis.
  • Only 10 (18%) patients had adenomatous polyp and 8 of these polyps were larger than 1 cm.
  • Overall US-based diagnosis of gallbladder polyp was inaccurate in 82%.
  • The sensitivity and specificity of US for polyps <1 cm was 20% and 95.1%, respectively, whereas the sensitivity and specificity of US for polyps >1 cm was 80% and 99.3%, respectively.
  • The accuracy of US in diagnosing PLGs was poor, especially in polyps <1 cm.

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  • (PMID = 18333181.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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64. Sotoudehmanesh R, Ainechi S, Asgari AA, Kolahdoozan S: Endoscopic lesions in low-to average-risk patients with minimal bright red bleeding from midline anal fissures. How much should we go in? Tech Coloproctol; 2007 Dec;11(4):340-2
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  • Adenomatous polyps were found in 4 cases (3.0%), ulcerative colitis in 8 (6.0%) and Crohn's disease in one patient (0.7%).

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  • (PMID = 18060528.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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65. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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66. Solomon SD, Pfeffer MA, McMurray JJ, Fowler R, Finn P, Levin B, Eagle C, Hawk E, Lechuga M, Zauber AG, Bertagnolli MM, Arber N, Wittes J, APC and PreSAP Trial Investigators: Effect of celecoxib on cardiovascular events and blood pressure in two trials for the prevention of colorectal adenomas. Circulation; 2006 Sep 5;114(10):1028-35
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  • METHODS AND RESULTS: The Adenoma Prevention With Celecoxib (APC) trial studied celecoxib 200 mg twice daily and 400 mg twice daily and the Prevention of Spontaneous Adenomatous Polyps (PreSAP) trial used 400 mg once daily totest the efficacy and safety of celecoxib against placebo in reducing colorectal adenoma recurrence after polypectomy.
  • Both dose groups in APC showed significant systolic blood pressure elevations at 1 and 3 years (200 mg twice daily: 1 year, 2.0 mm Hg; 3 years,2.6 mm Hg; 400 mg twice daily: 1 year, 2.9 mm Hg; 3 years, 5.2 mm Hg); however, the 400 mg once daily group inPreSAP did not (P0.0001 between studies).
  • [MeSH-major] Adenoma / prevention & control. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Blood Pressure / drug effects. Colorectal Neoplasms / prevention & control. Pyrazoles / therapeutic use. Sulfonamides / therapeutic use

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  • [CommentIn] Circulation. 2007 Mar 27;115(12):e348; author reply e349 [17389275.001]
  • (PMID = 16943394.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00005094/ NCT00141193
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Placebos; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib
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67. O'Connor SD, Summers RM, Yao J, Pickhardt PJ, Choi JR: CT colonography with computer-aided polyp detection: volume and attenuation thresholds to reduce false-positive findings owing to the ileocecal valve. Radiology; 2006 Nov;241(2):426-32
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  • [Title] CT colonography with computer-aided polyp detection: volume and attenuation thresholds to reduce false-positive findings owing to the ileocecal valve.
  • PURPOSE: To retrospectively identify volume and average attenuation thresholds for differentiating between ileocecal valve (ICV) and polyp at computed tomographic (CT) colonography with computer-aided detection (CAD).
  • A series of 2742 volume and attenuation thresholds, for which segmented findings both larger in volume and lower in average attenuation were labeled as ICVs and remaining findings were labeled polyps, were applied to the training set to determine settings with 100% sensitivity for polyp detection and the highest specificity for ICV detection.
  • RESULTS: A total of 386 ICVs and 67 adenomatous polyps from the training set and 102 ICVs and 138 adenomatous polyps from the test set could be segmented with a three-dimensional segmentation algorithm.
  • In the training set, a volume of 600 mm(3) and an attenuation of 36 HU provided 100% sensitivity (67 polyps; 95% CI: 93%, 100%) and the optimal 83% specificity (618 of 746 ICVs; 95% CI: 80%, 85%).
  • When applied to the test set, this combination provided 97% sensitivity (134 of 138 polyps; 95% CI: 92%, 99%) and 84% specificity (160 of 191 ICVs; 95% CI: 78%, 89%).
  • Differences in sensitivity and specificity in the detection of polyps between the sets were not significant.
  • CONCLUSION: Volume and average CT attenuation thresholds can help differentiate most ICVs from true polyps.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic. Ileocecal Valve / radiography. Radiographic Image Interpretation, Computer-Assisted

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  • (PMID = 17005773.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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68. John BJ, Irukulla S, Pilgrim G, Swift I, Abulafi AM: Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital. Colorectal Dis; 2008 Nov;10(9):898-900
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  • [Title] Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital.
  • INTRODUCTION: The British society of Gastroenterologists (BSG) have laid down guidelines for surveillance colonoscopies in patients with large bowel adenomatous polyps.
  • We audited our practice of polyp management and looked at guideline compliance amongst patients on our colonoscopic surveillance list.
  • METHOD: All patients undergoing adenoma surveillance and those with newly detected adenomas over a 2-month period were included in the first loop of the audit.
  • Amongst those on surveillance for polyps, compliance was ascertained as regards need for procedure and appropriateness of surveillance interval.
  • Of the patients on our colonoscopic waiting list for adenomatous polyps, 17.7% satisfied guidelines, 23.4% did not require any further surveillance and 58.9% were booked for a procedure earlier than recommended.
  • [MeSH-major] Colonic Polyps / surgery. Colonoscopy / utilization. Intestinal Polyps / surgery. Rectal Diseases / surgery

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  • (PMID = 19037930.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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69. Siddiqui AA, Maddur H, Naik S, Cryer B: The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitus. Dig Dis Sci; 2008 Apr;53(4):1042-7
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  • [Title] The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitus.
  • The aim of our study was to determine whether poor control of diabetes mellitus (DM) is associated with increased prevalence of colonic adenomatous polyps (APs), especially those that are advanced .
  • Significant variables by UA were included in a stepwise logistic regression analysis to determine independent predictors of aggressive clinical behavior by the polyps.
  • All values are presented as means +/- SE, and statistical significance was determined at P < or = 0.05.
  • Logistic regression, as measured by HbA1c, demonstrated that poorly controlled DM-2 independently predicted a greater prevalence of right-sided AP, a more advanced lesion at the time of presentation, a greater number of polyps, and greater use of exogenous insulin.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology. Colonic Neoplasms / blood. Colonic Neoplasms / pathology. Diabetes Mellitus, Type 2 / blood. Hemoglobin A, Glycosylated / metabolism

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  • (PMID = 17939046.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Hemoglobin A, Glycosylated; 0 / hemoglobin A1c protein, human
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70. Thirlwell C, Howarth KM, Segditsas S, Guerra G, Thomas HJ, Phillips RK, Talbot IC, Gorman M, Novelli MR, Sieber OM, Tomlinson IP: Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations. Br J Cancer; 2007 Jun 4;96(11):1729-34
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  • [Title] Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
  • Based on the precedent of MYH-associated polyposis (MAP), we searched for a mutational signature in 241 adenomatous polyps from our MCRA cases.
  • In sharp contrast to MAP tumours, we did not find evidence of a specific mutational signature in any individual patient or in the overall set of MCRA cases.
  • These results suggest that hypermutation of APC does not cause our patients' disease and strongly suggests that MAP is not a paradigm for the remaining MCRA patients.
  • Our MCRA patients' colons showed no evidence of microadenomas, unlike in MAP and familial adenomatous polyposis (FAP).
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Genes, APC. Germ-Line Mutation
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adult. Aged. Gene Expression Regulation, Neoplastic. Gene Frequency. Genetic Predisposition to Disease. Humans. Loss of Heterozygosity. Middle Aged. beta Catenin / genetics

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  • (PMID = 17505512.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / beta Catenin; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC2359923
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71. Siddiqui A, Pena Sahdala HN, Nazario HE, Mahgoub A, Patel M, Cipher D, Spechler S: Obesity is associated with an increased prevalence of advanced adenomatous colon polyps in a male veteran population. Dig Dis Sci; 2009 Jul;54(7):1560-4
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  • [Title] Obesity is associated with an increased prevalence of advanced adenomatous colon polyps in a male veteran population.
  • Obesity has been associated with an increased risk for colonic adenomatous polyps (APs) and colorectal cancers, but the influence of obesity on the development of advanced APs is not clear.
  • We identified 2,903 male patients with APs (mean age 64 + 1.1(SE) years; 770 (27%) normal weight, 1,029 (35%) overweight, 1,104 (38%) obese.
  • For every one-unit increase in BMI above 30, there was a corresponding 1% increase in the frequency of finding advanced APs.
  • Obesity in male veteran patients is associated with the finding of advanced APs on colonoscopy.
  • [MeSH-major] Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Obesity / epidemiology

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  • (PMID = 19399615.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Goto H, Oda Y, Murakami Y, Tanaka T, Hasuda K, Goto S, Sasaki Y, Sakisaka S, Hattori M: Proportion of de novo cancers among colorectal cancers in Japan. Gastroenterology; 2006 Jul;131(1):40-6
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  • BACKGROUND & AIMS: Adenomatous polyps are main precursors of colorectal cancers (CRCs).
  • In Japan, de novo cancers, which do not arise from preexisting adenomas, are considered to account for a substantial number of CRCs, but the relative importance of de novo carcinogenesis remains controversial.
  • Early cancers among CRCs detected in this study were classified as de novo cancers or polyp cancers derived from adenomas.
  • There were no differences with regard to size and location between de novo cancers and polyp cancers, but morphology differed.
  • [MeSH-minor] Adult. Aged. Colonic Polyps / epidemiology. Colonic Polyps / pathology. Female. Humans. Incidence. Intestinal Mucosa / pathology. Japan / epidemiology. Male. Middle Aged. Retrospective Studies. Risk Factors. Sex Distribution

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  • [CommentIn] Gastroenterology. 2006 Oct;131(4):1361; author reply 1361-2 [17030215.001]
  • (PMID = 16831588.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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73. Palozza P, Serini S, Maggiano N, Tringali G, Navarra P, Ranelletti FO, Calviello G: beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells. J Nutr; 2005 Jan;135(1):129-36
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  • Experimental studies have shown that beta-carotene inhibited the growth of colon cancer cells, and human trials have demonstrated that the carotenoid reduces colon cell proliferation of adenomatous polyps; however, molecular mechanisms underlying this chemopreventive activity remain unclear.
  • We evaluated the effects of beta-carotene on the growth of human colon adenocarcinoma cells overexpressing (LS-174, HT-29, WiDr) or not expressing (HCT116) COX-2.
  • This effect was not observed in cells treated with retinoic acid or retinol.
  • Moreover, cells not expressing COX-2 were insensitive to the growth-inhibitory and proapoptotic effects of the carotenoid.

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  • (PMID = 15623844.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Membrane Proteins; 0 / Neuregulin-1; 0 / Reactive Oxygen Species; 0 / heregulin alpha; 01YAE03M7J / beta Carotene; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS1 protein, human; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases; K7Q1JQR04M / Dinoprostone
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74. van den Broek I, Sparidans RW, Engwegen JY, Cats A, Depla AC, Schellens JH, Beijnen JH: Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer. Cancer Biomark; 2010;7(2):109-15
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  • Serum was obtained from patients with indications for colonoscopy, subsequently diagnosed as normal colon or hyperplastic polyp (CON; n= 368), adenomatous polyp (AP; n = 179) or colorectal cancer (CRC; n = 69).


75. Nam JH, Yang CH: [Clinical characteristics and risk factors of colon polyps in gyeongju and pohang area]. Korean J Gastroenterol; 2008 Sep;52(3):142-9
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  • [Title] [Clinical characteristics and risk factors of colon polyps in gyeongju and pohang area].
  • BACKGROUND/AIMS: The purposes of this study were to investigate various environmental factors for colon polyps and to analyze locoregional clinical characteristics of colon polyps in Gyeongju and Pohang area.
  • METHODS: From October 2005 to September 2006, patients who underwent colonoscopy were analyzed based on their ages, genders, body mass indices (BMI), dietary habits, smoking behaviors, accompaying diseases, and medications as risk factors for the occurrence of colon polyps.
  • Then clinical manifestations, gross appearances and pathologic findings of polyps were investigated.
  • RESULTS: Among 253 patients enrolled, a total of 296 colon polyps were found in 108 patients.
  • The incidence of colon polyps in more than 50-year old patients was 3.2-fold greater compared to less than 50-year old patients.
  • Smoking habits were also significantly associated with the occurence of colon polyps.
  • Among adenomatous polyps, tubulovillous type and moderate to severe dysplasia were frequently observed as the size increased, yet the location of polyps was not significantly associated.
  • CONCLUSIONS: Older age and smoking habit increase the risk of colon polyps.
  • Rectal polyps have less chance to be adenomatous type.
  • The larger the polyp grows, the more likely it to be tubulovillous and dysplastic.
  • [MeSH-major] Colonic Polyps / diagnosis. Colorectal Neoplasms / diagnosis
  • [MeSH-minor] Adenomatous Polyps / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Korea. Male. Middle Aged. Multivariate Analysis. Odds Ratio. Risk Factors. Rural Population. Surveys and Questionnaires

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  • (PMID = 19077510.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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76. Levi Z, Vilkin A, Niv Y: Esophago-gastro-duodenoscopy is not indicated in patients with positive immunochemical test and nonexplanatory colonoscopy. Eur J Gastroenterol Hepatol; 2010 Dec;22(12):1431-4
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  • [Title] Esophago-gastro-duodenoscopy is not indicated in patients with positive immunochemical test and nonexplanatory colonoscopy.
  • In this study, we evaluated EGD findings in patients with positive immunochemical fecal occult blood test (I-FOBT) not explained by colonoscopy.
  • METHODS: Out of 1221 consecutive patients having total colonoscopy after preparing I-FOBT (OC-MICRO, with threshold of 75 or 100 ngHb/ml), we included only patients without colorectal cancer or advanced adenomatous polyp on colonoscopy, who also underwent EGD within 4 months of the fecal blood testing.
  • CONCLUSION: Immunological FOBT positivity was not correlated with the finding of lesions, which are likely to bleed on EGD.
  • Thus, EGD is probably not indicated in patients with positive I-FOBT and unrevealing colonoscopy.

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  • (PMID = 20962660.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Sjursen W, Bjørnevoll I, Engebretsen LF, Fjelland K, Halvorsen T, Myrvold HE: A homozygote splice site PMS2 mutation as cause of Turcot syndrome gives rise to two different abnormal transcripts. Fam Cancer; 2009;8(3):179-86
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  • Turcot syndrome is a rare, inherited disease predisposing of tumours in the central nerve system and in the colorectal system.
  • She has since then been treated for multiple cancers (gastrointestinal, endometrial, basal cell carcinomas), and removal of adenomatous polyps at several occasions.
  • The patients genotype was found to be a homozygous splice site mutation in the PMS2 gene, c.989-1G<T, which resulted in two abnormal transcripts, not one as expected.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Adenosine Triphosphatases / genetics. DNA Repair Enzymes / genetics. DNA-Binding Proteins / genetics

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  • (PMID = 19039682.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA-Binding Proteins; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / PMS2 protein, human; EC 3.6.1.3 / Mismatch Repair Endonuclease PMS2; EC 6.5.1.- / DNA Repair Enzymes
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78. Botma A, Nagengast FM, Braem MG, Hendriks JC, Kleibeuker JH, Vasen HF, Kampman E: Body mass index increases risk of colorectal adenomas in men with Lynch syndrome: the GEOLynch cohort study. J Clin Oncol; 2010 Oct 1;28(28):4346-53
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  • The objective of this study was to assess whether BMI is associated with colorectal adenoma occurrence in persons with LS.
  • This association was not observed among women (overweight v normal weight HR, 0.75; 95% CI, 0.19 to 3.07), nor was it observed in the prevalent cohort.
  • In the incident cohort, height was statistically significantly associated with a decreased risk of adenomatous polyps among men (per 5 cm HR, 0.43; 95% CI, 0.23 to 0.83), but the association between weight and adenomatous polyps among men was of marginal significance (per 5 kg HR, 1.17; 95% CI, 1.00 to 1.37).
  • [MeSH-major] Adenoma / epidemiology. Body Mass Index. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms, Hereditary Nonpolyposis / epidemiology


79. Loh K, Chia JA, Greco S, Cozzi SJ, Buttenshaw RL, Bond CE, Simms LA, Pike T, Young JP, Jass JR, Spring KJ, Leggett BA, Whitehall VL: Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development. Genes Chromosomes Cancer; 2008 Jun;47(6):449-60
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  • Methylation was also frequently observed in serrated and traditional adenomatous polyps (22/29, 76%).
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adenoma / genetics. Adenoma / metabolism. Bone Morphogenetic Protein 3. Cell Line, Tumor. Cohort Studies. Colonic Polyps / genetics. Colonic Polyps / metabolism. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / metabolism. CpG Islands. Disease Progression. Humans. Intestinal Mucosa / metabolism. Loss of Heterozygosity. Microsatellite Instability. Nuclear Proteins / genetics. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Promoter Regions, Genetic / genetics. Subtraction Technique. Tumor Stem Cell Assay


80. Iarŭmov N, Toshev S, Petrova D, Angelov K, Gribnev P, Sokolov M: [Genetic counseling, surgical prophylaxis and treatment for familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer]. Khirurgiia (Sofiia); 2007;(3):46-53
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  • [Title] [Genetic counseling, surgical prophylaxis and treatment for familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer].
  • FAP is an autosomal dominant disorder characterized by the appearance of thousands of adenomatous polyps.
  • If an adenoma or adenocarcinoma of the colon is identified, total abdominal colectomy with an ileorectal anastomosis is recommended.
  • [MeSH-major] Adenomatous Polyposis Coli. Colorectal Neoplasms, Hereditary Nonpolyposis. Genetic Counseling. Intestine, Large / surgery


81. Ma YM, Wu BP, Xia OD: [Expression and significance of interferon-inducible transmembrane protein-1 gene in Peutz-Jeghers syndrome]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Mar;29(3):541-3
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  • OBJECTIVE: To detect the mRNA and protein expression of interferon-inducible transmembrane protein-1 (IFITM1) in Peutz-Jeghers syndrome (PJS) and investigate the role of IFITM1 in the occurrence, development and carcinogenesis of PJS polyps.
  • METHODS: Reverse transcription-PCR was employed to detect the mRNA expression of IFITM1 in 16 PJS polyp samples, adenomatous polyp tissues, colon adenocarcinoma samples, and normal intestinal mucosal tissues.
  • RESULTS: The IFITM1 mRNA expression was detected in all these tissues, and the expression intensity increased in the order of normal intestinal mucosa, PJS polyp, adenomatous polyp, and colon adenocarcinoma (F=92.704, P=0.000).
  • CONCLUSION: The expression level of IFITM1 is associated with the progression of the carcinogenetic process in PJS polyp, and can be used as a sensitive biomarker for diagnosis and prognostic evaluation of PJS.
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Differentiation. Biomarkers / metabolism. Disease Progression. Female. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Young Adult

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  • (PMID = 19304549.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Biomarkers; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / leu-13 antigen
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82. Yang LP, Yang ZL, Tan XG, Miao XY: [Expression of annexin A1 (ANXA1) and A2 (ANXA2) and its significance in benign and malignant lesions of gallbladder]. Zhonghua Zhong Liu Za Zhi; 2010 Aug;32(8):595-9
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  • OBJECTIVE: To study the expression levels of ANXA1 and ANXA2 and elucidate their clinicopathological significance in adenocarcinoma, peritumoral tissues, adenomatous polyp and chronic cholecystitis of gallbladder.
  • METHODS: EnVision(TM) immunohistochemical staining was used to detect the expression of ANXA1 and ANXA2 in paraffin-embedded tissue sections from resected specimens of adenocarcinoma (n = 108), peritumoral tissue (n = 46), adenomatous polyp (n = 15) and chronic cholecystitis (n = 35).
  • RESULTS: The positive rates and scores of ANXA1 and ANXA2 were significantly higher in adenocarcinoma (59.3%, 56.5%; 3.2 ± 0.9, 3.4 ± 0.8) than those in peritumoral tissues (34.8%, 1.1 ± 0.8, P < 0.01; 30.4%, 1.0 ± 0.8, P < 0.01), adenomatous polyp (26.7%, 0.9 ± 0.7, P < 0.05 or P < 0.01; 26.7%, 0.9 ± 0.8, P < 0.05 or P < 0.01) and chronic cholecystitis (17.1%, 0.7 ± 0.9, P < 0.01; 20.0%, 0.8 ± 0.8, P < 0.01).
  • Kaplan-Meier analysis and multivariate Cox regression analysis showed that ANXA1 or ANXA2 was not an independent prognostic predictor in gallbladder adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenomatous Polyps / metabolism. Adenomatous Polyps / pathology. Adult. Aged. Cholecystectomy / methods. Cholecystitis / metabolism. Cholecystitis / pathology. Female. Gallbladder / metabolism. Gallbladder / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Proportional Hazards Models. Survival Rate

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  • (PMID = 21122411.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ANXA2 protein, human; 0 / Annexin A1; 0 / Annexin A2
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83. Larrinaga G, Perez I, Blanco L, López JI, Andrés L, Etxezarraga C, Santaolalla F, Zabala A, Varona A, Irazusta J: Increased prolyl endopeptidase activity in human neoplasia. Regul Pept; 2010 Aug 9;163(1-3):102-6
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  • Both cytosolic and membrane-bound PEP activity were also increased in colorectal adenomatous polyps.

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  • [Copyright] Copyright (c) 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20362629.001).
  • [ISSN] 1873-1686
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.26 / prolyl oligopeptidase
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84. Chatelain D, Terris B, Fléjou JF: [Serrated neoplasia of the gastro-intestinal tract]. Ann Pathol; 2006 Apr;26(2):86-96; quiz 85
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  • Some serrated polyps seem to be involved in a new carcinogenic pathway in the colon: the serrated neoplasia pathway, with hypermethylation of the cytosine-guanine dinucleotides, located in the promoter of some genes such as h-MLH1, BRAF and MGMT.
  • The natural history of the serrated polyps and their risk for progression to malignancy are still unclear.
  • There is no official guideline for the management of serrated polyps.
  • The aim of this article is to describe the epidemiological, morphological, immunohistochemical and molecular characteristics of the serrated neoplasia of the gastrointestinal tract: hyperplastic polyps, "traditional" serrated adenomas, mixed hyperplastic and adenomatous polyps, sessile serrated adenomas, hyperplastic polyposis and serrated adenocarcinomas.
  • [MeSH-major] Adenoma / pathology. Gastrointestinal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Humans. Hyperplasia / pathology. Intestinal Polyps / pathology

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  • (PMID = 16791120.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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85. Ji BT, Weissfeld JL, Chow WH, Huang WY, Schoen RE, Hayes RB: Tobacco smoking and colorectal hyperplastic and adenomatous polyps. Cancer Epidemiol Biomarkers Prev; 2006 May;15(5):897-901
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  • [Title] Tobacco smoking and colorectal hyperplastic and adenomatous polyps.
  • Colorectal adenomas and possibly some hyperplastic polyps are precursors of colorectal cancer.
  • Tobacco use is associated in epidemiologic studies with these polyps, although links between smoking and colorectal cancer are less consistent.
  • To characterize the role of tobacco in early colorectal carcinogenesis, we compared tobacco use among 4,383 subjects with histologically verified benign (hyperplastic or adenomatous) polyps of the distal colon (descending colon, sigmoid, and rectum) with tobacco use among 33,667 subjects who were endoscopy negative for distal colon tumors, in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Trial, a randomized trial of flexible sigmoidoscopy.
  • Risks, estimated by the odds ratio (OR), associated with current cigarette use were OR = 4.4 [95% confidence interval (95% CI), 3.7-5.2] for hyperplastic polyps only, OR = 1.8 (95% CI, 1.5-2.1) for adenomas only, and OR = 6.2 (95% CI, 4.7-8.3) for subjects with both hyperplastic and adenomatous polyps concurrently.
  • Effects were weaker among ex smokers; the smoking-associated ORs remained consistently higher for hyperplastic polyps.
  • Tobacco-associated risks for multiple polyps were also stronger when hyperplastic disease was involved.
  • In conclusion, tobacco use, particularly recent use, increases risk for both adenomatous and hyperplastic polyps, but the risks are substantially greater for hyperplastic lesions.
  • [MeSH-major] Adenomatous Polyposis Coli / etiology. Colorectal Neoplasms / etiology. Smoking / adverse effects

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  • (PMID = 16702367.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
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86. Benes Z, Antos Z: Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy. Anticancer Res; 2009 Nov;29(11):4737-9
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  • [Title] Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy.
  • BACKGROUND: It has been established that the removal of adenomatous colon polyps drastically reduces the incidence of colorectal cancer (CRC), but polypectomy is not without risk.
  • The aim was to determine the correlation between the results of an optical biopsy system and the histopathology report of the physical biopsy specimens of the same polyps removed at colonoscopy.
  • PATIENTS AND METHODS: Paired optical and physical biopsies were performed on 55 polyps with complete polypectomy of the same tissue.
  • RESULTS: Fifty-three adenomatous polyps and two hyperplastic polyps were identified by the hospital pathologist.
  • The optical biopsy system identified 52 polyps as suspect (adenomatous) and 2 as non-suspect (hyperplastic).
  • One villous adenoma could not be optically analyzed due to friability.
  • CONCLUSION: The WavSTAT Optical Biopsy System provides accurate information to the gastroenterologist to assist in distinguishing between hyperplastic and adenomatous polyps.
  • It is safe for the patient and does not unduly increase the time required for an endoscopic examination.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colon / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy / methods. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonoscopy / methods. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Middle Aged. Optics and Photonics / methods. Prospective Studies

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  • (PMID = 20032428.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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87. Mathew J, Saklani AK, Borghol M: Surveillance colonoscopy in patients with colorectal cancer: how often should we be doing it? Surgeon; 2006 Feb;4(1):3-5, 62
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  • BACKGROUND: The optimum protocol for colonoscopic surveillance following curative resection for colorectal cancer has not been established.
  • The variables studied included the tumour site, Duke's stage, number of recurrences, number of metachronous tumours, size and number of polyps and their biopsy results.
  • Adenomatous polyps were identified in 24 patients of which nine had multiple/advanced adenomas (equal to or more than 1cm adenomatous polyps, or with severe dysplasia).
  • [MeSH-major] Adenoma / surgery. Colonoscopy / statistics & numerical data. Colorectal Neoplasms / surgery. Neoplasm Recurrence, Local / diagnosis

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  • [CommentIn] Surgeon. 2007 Apr;5(2):125 [17455380.001]
  • (PMID = 16459492.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Scotland
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88. Tanaka T: Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog; 2009;8:5
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  • The large majority of colorectal malignancies develop from an adenomatous polyp (adenoma).
  • Carcinomas usually originate from pre-existing adenomas, but this does not imply that all polyps undergo malignant changes and does not exclude de novo oncogenesis.
  • Besides adenomas, there are other types of pre-neoplasia, which include hyperplastic polyps, serrated adenomas, flat adenomas and dysplasia that occurs in the inflamed colon in associated with inflammatory bowel disease.

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  • (PMID = 19332896.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2678864
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89. Jung AY, Poole EM, Bigler J, Whitton J, Potter JD, Ulrich CM: DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps. Cancer Epidemiol Biomarkers Prev; 2008 Feb;17(2):330-8
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  • [Title] DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps.
  • In a case-control study of colorectal polyps, we evaluated three single nucleotide polymorphisms (-149C>T, -283T>C, -579G>T) in the promoter region of the DNMT3b gene, and a functional polymorphism in the coding region of the alcohol dehydrogenase ADH1C gene, ADH1C *2.
  • Cases had a first diagnosis of colorectal adenomatous (n = 530) or hyperplastic (n = 202) polyps at the time of colonoscopy, whereas controls were polyp-free (n = 649).
  • There were no significant main associations between the DNMT3b or ADH1C polymorphisms and polyp risk.
  • However, DNMT3b -149TT was associated with an increase in adenoma risk among individuals with low folate and methionine intake (OR, 2.00; 95% CI, 1.06-3.78, P interaction = 0.10).
  • The ADH1C *2/*2 genotype was associated with a possibly elevated risk for adenomatous polyps among individuals who consumed >26 g of alcohol/d (OR, 1.95; 95% CI, 0.60-6.30), whereas individuals who were wild-type for ADH1C were not at increased risk of adenoma (P interaction = 0.01).
  • [MeSH-major] Adenomatous Polyps / enzymology. Adenomatous Polyps / genetics. Alcohol Dehydrogenase / genetics. Colonic Polyps / enzymology. Colonic Polyps / genetics. DNA (Cytosine-5-)-Methyltransferase / genetics
  • [MeSH-minor] Adult. Aged. Colonoscopy. DNA Methylation. Female. Genetic Predisposition to Disease. Genotype. Haplotypes. Humans. Logistic Models. Male. Middle Aged. Polymorphism, Single Nucleotide. Promoter Regions, Genetic

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  • (PMID = 18268116.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / Alcohol Dehydrogenase; EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA methyltransferase 3B
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90. Alder AC, Hamilton EC, Anthony T, Sarosi GA Jr: Cancer risk in endoscopically unresectable colon polyps. Am J Surg; 2006 Nov;192(5):644-8
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  • [Title] Cancer risk in endoscopically unresectable colon polyps.
  • BACKGROUND: The purpose of the current study was to define the rate of underlying malignancy in endoscopically unresectable polyps.
  • METHODS: An institutional review board-approved review identified all patients undergoing colectomy for radiologically identified or endoscopically unresectable polyps between 1997 and 2006.
  • Patients were included if the endoscopic impression and biopsy findings suggested an adenomatous polyp without invasive cancer.
  • The median endoscopic size of polyps was 3.0 cm (range 0.8 to 10 cm).
  • Polyps were most frequently proximal to the splenic flexure (72%).
  • Size of polyp (P = .81) and histologic type (P = .34) were not significantly associated with invasive cancer.
  • Compared with polyps proximal to the splenic flexure, polyps located distally were more likely to harbor malignancy (rate; P < .02), by both univariate and multivariate analysis (odds ratio [OR] 1.38 [95% confidence interval 1.07 to 1.8]).
  • CONCLUSION: The cancer risk in polyps deemed inappropriate for endoscopic resection was lower than previously reported.
  • Neither polyp size nor histologic type appeared to be significantly associated with invasive cancer.
  • Location of an endoscopically unresectable polyp distal to the splenic flexure confers an increased risk for occult malignancy.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology

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  • (PMID = 17071200.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Mukhopadhyay S, Marhaba A, Sidhu JS: Small advanced neuroendocrine carcinoma of rectum discovered in an adenomatous polyp. Endoscopy; 2005 Dec;37(12):1256-7
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  • [Title] Small advanced neuroendocrine carcinoma of rectum discovered in an adenomatous polyp.
  • [MeSH-major] Carcinoma, Neuroendocrine / secondary. Colonic Polyps / pathology. Liver Neoplasms / secondary. Rectal Neoplasms / pathology

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  • (PMID = 16329031.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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92. Augoff K, Rabczynski J, Tabola R, Czapla L, Ratajczak K, Grabowski K: Immunohistochemical study of decorin expression in polyps and carcinomas of the colon. Med Sci Monit; 2008 Oct;14(10):CR530-5
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  • [Title] Immunohistochemical study of decorin expression in polyps and carcinomas of the colon.
  • It was hypothesized that physiological expression of decorin may be associated with cellular senescence of the colorectal mucosa and that its down-regulation, promoting an increase in cellular proliferation, could participate in the progression of adenoma to adenocarcinoma.
  • Therefore the expression of decorin in hyperplastic and neoplastic polyps of the colorectum was examined and compared with normal colonic mucosa and colon cancer tissues.
  • MATERIAL/METHODS: Tissue samples were obtained from 41 patients with different types of colonic polyps (6 hyperplastic adenomas, 34 neoplastic adenomas, and 1 adenomatous polyp with focal carcinoma) and 12 patients with colon cancer.
  • The decrease in decorin reactivity in tubulo-villous adenomas was significant as compared with other polyps and controls.
  • Weak decorin immunoreactivity in stroma adjacent to clusters of cancerous cells was also found in most cases of common types of adenocarcinoma, but not in adenocarcinoma mucinosum.
  • CONCLUSIONS: The expression of decorin may be involved in the differentiation of colonic polyps and reduced expression of decorin may abrogate the defensive potential of stromal tissue and promote the development of common types of colon carcinoma.
  • [MeSH-major] Colon / pathology. Colonic Polyps / metabolism. Colorectal Neoplasms / metabolism. Extracellular Matrix Proteins / metabolism. Proteoglycans / metabolism

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  • (PMID = 18830193.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans
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93. Telang N, Katdare M: Cell culture model for colon cancer prevention and therapy: an alternative approach to animal experimentation. ALTEX; 2007;24(1):16-21
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  • Mouse models for colon cancer that harbor a germ line mutation in the tumor suppressor gene Adenomatous polyposis coli (Apc) exhibit a primary genetic defect that predisposes to a high incidence of adenomatous polyps in the small intestine rather than in the colon.

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  • (PMID = 17361317.001).
  • [ISSN] 1868-596X
  • [Journal-full-title] ALTEX
  • [ISO-abbreviation] ALTEX
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-29502-20; United States / NCI NIH HHS / CA / CA-29502-S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Antineoplastic Agents
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94. Butterly LF, Chase MP, Pohl H, Fiarman GS: Prevalence of clinically important histology in small adenomas. Clin Gastroenterol Hepatol; 2006 Mar;4(3):343-8
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  • BACKGROUND & AIMS: The prevalence of advanced histology in small polyps has become a crucial issue in optimizing colorectal cancer screening strategies, especially in view of the advent of computed tomography colonography.
  • METHODS: Data were reviewed retrospectively from 3291 colonoscopies performed on asymptomatic patients found to have an adenoma on screening with flexible sigmoidoscopy a few weeks before the colonoscopy or who had a family history of colorectal cancer.
  • All polyps were excised endoscopically and sent for pathology testing.
  • RESULTS: Of the 3291 colonoscopies performed, 1235 colonoscopies yielded a total of 1933 small or diminutive adenomatous polyps.
  • Of the 107 patients found to have polyps 2-10 mm with advanced histology, 100 (93%) were referred for colonoscopy because of an adenoma found on a recent screening with flexible sigmoidoscopy.
  • [MeSH-major] Adenomatous Polyps / pathology. Carcinoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Colonoscopy. Disease Progression. Female. Humans. Male. Middle Aged. Prevalence

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  • [CommentIn] Nat Clin Pract Gastroenterol Hepatol. 2006 Sep;3(9):488-9 [16951664.001]
  • [CommentIn] Clin Gastroenterol Hepatol. 2006 Mar;4(3):293-5 [16527690.001]
  • (PMID = 16527698.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Dixon A, Wurm P, Hart A, Robinson R: Distal adenomatous polyps are rare in patients with inflammatory bowel disease. Postgrad Med J; 2006 Jan;82(963):76-8
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  • [Title] Distal adenomatous polyps are rare in patients with inflammatory bowel disease.
  • OBJECTIVE: There is an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD).
  • RESULTS: Of 106 patients (61 male, 45 female, mean age of 59 years), 80 suffered from ulcerative colitis, 20 from Crohn's disease, and six from indeterminate colitis.
  • CONCLUSIONS: The results suggest that distal adenomatous polyps are rare in patients aged 55-64 years with IBD compared with a control population.
  • This supports the hypothesis that lesions other than polyps are important for the development of colorectal cancer in patients with IBD.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / etiology. Inflammatory Bowel Diseases / etiology

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  • (PMID = 16397087.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 4Q81I59GXC / Mesalamine; MRK240IY2L / Azathioprine
  • [Other-IDs] NLM/ PMC2563726
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96. Su YH, Wang M, Aiamkitsumrit B, Brenner DE, Block TM: Detection of a K-ras mutation in urine of patients with colorectal cancer. Cancer Biomark; 2005;1(2-3):177-82
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  • We further compared, in a blinded study, the frequency of detecting mutated K-ras sequence in DNA isolated from plasma and urine derived from individuals who have either a colorectal carcinoma (CRC), or adenomatous polyps that contain a mutation in codon 12 of the K-ras proto-oncogene.
  • There was an 83% concurrence of mutated DNA detected in urine and its corresponding disease tissue from the same individuals, when paired urine and tissue sections from 20 patients with either CRC or adenomatous polyps were analyzed for K-ras mutation.
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / urine. DNA / classification. DNA / urine. Humans. Mutation. Nucleic Acid Denaturation. Peptide Nucleic Acids. Polymerase Chain Reaction / methods

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  • (PMID = 17192038.001).
  • [ISSN] 1574-0153
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA86400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Peptide Nucleic Acids; 9007-49-2 / DNA; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Number-of-references] 19
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97. Gibson CJ, Parry NM, Jakowski RM, Cooper J: Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog. Vet Pathol; 2010 Jan;47(1):116-9
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  • [Title] Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog.
  • Endoscopically, the distal aspect of the esophagus was inflamed with a polypoid mass that protruded into the esophageal lumen.
  • This article reports a case of spontaneous esophageal adenomatous polyp with intestinal metaplasia (Barrett esophagus) and reviews the pathogenesis of esophageal metaplasia and adenocarcinoma.
  • [MeSH-major] Adenomatous Polyps / veterinary. Barrett Esophagus / veterinary. Dog Diseases / pathology. Esophageal Neoplasms / veterinary. Intestines / pathology

  • MedlinePlus Health Information. consumer health - Esophageal Cancer.
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  • (PMID = 20080491.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. McKenzie S, Baek JH, Wakabayashi M, Garcia-Aguilar J, Pigazzi A: Totally laparoscopic right colectomy with transvaginal specimen extraction: the authors' initial institutional experience. Surg Endosc; 2010 Aug;24(8):2048-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A four-trocar laparoscopic right colectomy with intracorporeal anastomosis was performed for cancer in two cases and for adenomatous polyp in two cases.

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  • [CommentIn] Surg Endosc. 2011 May;25(5):1699-700 [20972582.001]
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  • [ISSN] 1432-2218
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  • [ISO-abbreviation] Surg Endosc
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99. Fujimura T, Ohta T, Oyama K, Miyashita T, Miwa K: Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers. J Gastrointest Cancer; 2007;38(2-4):78-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • DISCUSSION: Since a randomized study for polyp chemoprevention by celecoxib in familial adenomatous polyposis (FAP) patients demonstrated a significant reduction in the number of colorectal polyps, the clinical use of celecoxib was approved for FAP patients.
  • Three large trials using celecoxib (the Adenoma Prevention with Celebrex and the Prevention of Spontaneous Adenomatopus Polyps) or refecoxib (the Adenomatous Polyp Prevention on Vioxx) for the recurrence of colorectal polyps in patients with a history of colorectal adenoma polypectomized confirmed chemopreventive effects on colorectal adenoma but two of three trails alerted us a hazard of cardiovascular (CV) events.

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  • (PMID = 19031117.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  • [Number-of-references] 36
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100. Ahmad I, Khan AA, Alam A, Butt AK, Shafqat F, Sarwar S: A study of colorectal polyps. J Coll Physicians Surg Pak; 2006 May;16(5):364-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A study of colorectal polyps.
  • OBJECTIVE: To determine various features of colorectal polyps and to evaluate the safety of colonoscopic polypectomy.
  • Polyps were evaluated in terms of size, site, number and histopathology.
  • Two hundred and sixty-four patients had juvenile polyps, 39 had adenomatous polyps, 39 hyperplastic polyps, 39 inflammatory polyps, 3 malignant polyps and 2 patients had familial polyposis.
  • Histopathological reports were not available in 7 patients.
  • Size of the polyps ranged from 0.3 cm to 3.0 cm.
  • CONCLUSION: Juvenile polyps were the commonest variety of polyps in our study.
  • [MeSH-major] Colonic Polyps

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  • (PMID = 16756784.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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