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1. Goddard AF, Badreldin R, Pritchard DM, Walker MM, Warren B, British Society of Gastroenterology: The management of gastric polyps. Gut; 2010 Sep;59(9):1270-6
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  • [Title] The management of gastric polyps.
  • BACKGROUND: Gastric polyps are important as some have malignant potential.
  • If such polyps are left untreated, gastric cancer may result.
  • The malignant potential depends on the histological type of the polyp.
  • DEFINITION: Gastric polyps are sessile or pedunculated lesions that originate in the gastric epithelium or submucosa and protrude into the stomach lumen.
  • MALIGNANT POTENTIAL: Depending on histological type, some gastric polyps (adenomas and hyperplastic polyps) have malignant potential and are precursors of early gastric cancer.
  • [MeSH-major] Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Evidence-Based Medicine / methods. Gastroscopy / methods. Humans. Precancerous Conditions / diagnosis. Precancerous Conditions / surgery. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery

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  • (PMID = 20675692.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Review
  • [Publication-country] England
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2. Lieberman D: Eighty-year-old patient with history of a twelve millimeter adenomatous polyp resected at age of seventy-five years. Clin Gastroenterol Hepatol; 2007 Feb;5(2):166-9
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  • [Title] Eighty-year-old patient with history of a twelve millimeter adenomatous polyp resected at age of seventy-five years.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis

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  • (PMID = 17296526.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Micheletto G, Sciannamea I, Zanoni A, Panizzo V, Rubino B, Danelli P: [Intestinal neuroendocrine tumor. Case report and review of the literature]. Ann Ital Chir; 2009 Jul-Aug;80(4):319-24
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  • Here we report a case of a 73-year-old male with an adenomatous colonic polyp, not suitable of endoscopic treatment, and a synchronous carcinoid of small intestine discovered during surgical procedure.
  • [MeSH-major] Adenoma. Carcinoid Tumor. Colonic Polyps. Ileal Neoplasms. Neoplasms, Multiple Primary. Sigmoid Neoplasms


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4. Ayoub J, Granado B, Mhanna Y, Romain O: SVM based colon polyps classifier in a wireless active stereo endoscope. Conf Proc IEEE Eng Med Biol Soc; 2010;2010:5585-8
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  • [Title] SVM based colon polyps classifier in a wireless active stereo endoscope.
  • This work focuses on the recognition of three-dimensional colon polyps captured by an active stereo vision sensor.
  • The study is related to Cyclope, this prototype sensor allows real time 3D object reconstruction and continues to be optimized technically to improve its classification task by differentiation between hyperplastic and adenomatous polyps.
  • Inspired by intensity histogram, the work shows a new approach that extracts a set of features based on depth histogram and combines stereo measurement with SVM classifiers to correctly classify benign and malignant polyps.
  • [MeSH-major] Algorithms. Colonic Polyps / classification. Endoscopes. Wireless Technology / instrumentation

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  • (PMID = 21096484.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Laiyemo AO, Murphy G, Albert PS, Sansbury LB, Wang Z, Cross AJ, Marcus PM, Caan B, Marshall JR, Lance P, Paskett ED, Weissfeld J, Slattery ML, Burt R, Iber F, Shike M, Kikendall JW, Lanza E, Schatzkin A: Postpolypectomy colonoscopy surveillance guidelines: predictive accuracy for advanced adenoma at 4 years. Ann Intern Med; 2008 Mar 18;148(6):419-26
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  • [Title] Postpolypectomy colonoscopy surveillance guidelines: predictive accuracy for advanced adenoma at 4 years.
  • DESIGN: Analysis of prospective data from the Polyp Prevention Trial.
  • MEASUREMENTS: Baseline adenoma characteristics, risk-stratified according to definitions used in the guidelines, were examined as predictors for advanced adenoma recurrence.
  • RESULTS: 125 patients (6.6%) had advanced and 629 (33.0%) had nonadvanced adenoma recurrence; 1151 (60.4%) had no recurrence within 4 years of follow-up.
  • The probability of advanced adenoma recurrence was 0.09 (95% CI, 0.07 to 0.11) among patients with high-risk adenomas at baseline and 0.05 (CI, 0.04 to 0.06) among those with low-risk adenomas at baseline.
  • The relative risk for advanced adenoma recurrence for patients with high-risk adenomas versus those with low-risk adenomas at baseline was 1.68 (CI, 1.19 to 2.38) when advanced adenoma recurrence was compared with no advanced adenoma recurrence and 1.76 (CI, 1.26 to 2.46) when advanced adenoma recurrence was compared with no adenoma recurrence.
  • CONCLUSION: Although the risk for recurrence of advanced adenoma within 4 years is greater for patients with high-risk adenomas at baseline than for those with low-risk adenomas, the discrimination of this risk stratification scheme is relatively low.
  • [MeSH-major] Adenoma / diagnosis. Adenomatous Polyps / surgery. Colonic Polyps / surgery. Colonoscopy. Colorectal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Practice Guidelines as Topic / standards

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  • [CommentIn] Ann Intern Med. 2008 Mar 18;148(6):477-9 [18347353.001]
  • [CommentIn] Gastroenterology. 2008 Dec;135(6):2147-9 [19000678.001]
  • [CommentIn] Ann Intern Med. 2008 Sep 2;149(5):360; author reply 360-1 [18765710.001]
  • (PMID = 18347350.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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6. Avanesian AA, Shcherbakov AM: [An experience with clinical endoscopy and argon-plasma coagulation for removal of large bowel polyps]. Vopr Onkol; 2005;51(5):592-4
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  • [Title] [An experience with clinical endoscopy and argon-plasma coagulation for removal of large bowel polyps].
  • Polyps presented as sitting on a wide pedicle (25), sprawling (19) or spreading flat (7) in rectum (24), sigmoid (18) or colon (9).
  • Polyp diameter ranged 1.0-1.9 cm (12 adenomas), 2-2.9 (18) or 3-5 cm (21).
  • Coagulation was carried out immediately after partial removal of polyp with the aid of diathermic loop.
  • During follow-up (6-24 months), out of 40 patients with 51 polyps, histologically identifiable villous adenoma was detected in 3 (during 12 months).
  • That technique proved more effective and safer than traditional methods in dealing with large polyps of the large bowel having a wide pedicle and/or sprawling.
  • [MeSH-minor] Adenomatous Polyposis Coli / surgery. Adult. Aged. Aged, 80 and over. Argon / therapeutic use. Female. Follow-Up Studies. Humans. Male. Middle Aged. Plasma. Retrospective Studies. Treatment Outcome

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  • (PMID = 16756019.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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7. Chan MY, Cohen H, Spiegel BM: Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital. Clin Gastroenterol Hepatol; 2009 Nov;7(11):1217-23; quiz 1143
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  • [Title] Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital.
  • BACKGROUND & AIMS: One objective of colonoscopy is to identify and remove polyps-this process requires attention to detail and prolonged concentration.
  • We measured the adjusted relationship between colonoscopy start time and polyp yield.
  • The primary outcome measure was polyp yield.
  • We identified significant risk factors using univariate analysis and performed Poisson multivariable regression to measure the independent effect of colonoscopy start time on polyp yield.
  • We evaluated evidence of decreasing polyp yield as the day progressed throughout pre-specified time intervals.
  • RESULTS: In univariate analysis, early-morning cases yielded 27% more polyps per patient than later cases (95% confidence interval, 11%-45%; P < .001).
  • The total numbers of, hyperplastic and adenomatous polyps found decreased hour-by-hour as the day progressed.
  • Multivariable analysis demonstrated that early-morning cases yielded 20% more polyps per patient than later cases (95% confidence interval, 5%-38%; P = .007).
  • CONCLUSIONS: At a VA medical center, more polyps were detected in patients that received colonoscopies early in the morning compared with later in the day.
  • Moreover, adenoma detection reduced as the day progressed.
  • Providers might be most adept at detecting polyps at the beginning of the day; further validation in other practice settings is required.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Colonoscopy. Diagnostic Errors / statistics & numerical data. Health Services Research. Polyps / diagnosis. Time Factors

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  • (PMID = 19631284.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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8. Telang N, Katdare M: Cell culture model for colon cancer prevention and therapy: an alternative approach to animal experimentation. ALTEX; 2007;24(1):16-21
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  • Mouse models for colon cancer that harbor a germ line mutation in the tumor suppressor gene Adenomatous polyposis coli (Apc) exhibit a primary genetic defect that predisposes to a high incidence of adenomatous polyps in the small intestine rather than in the colon.

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  • (PMID = 17361317.001).
  • [ISSN] 1868-596X
  • [Journal-full-title] ALTEX
  • [ISO-abbreviation] ALTEX
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-29502-20; United States / NCI NIH HHS / CA / CA-29502-S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Antineoplastic Agents
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9. Butterly LF, Chase MP, Pohl H, Fiarman GS: Prevalence of clinically important histology in small adenomas. Clin Gastroenterol Hepatol; 2006 Mar;4(3):343-8
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  • BACKGROUND & AIMS: The prevalence of advanced histology in small polyps has become a crucial issue in optimizing colorectal cancer screening strategies, especially in view of the advent of computed tomography colonography.
  • METHODS: Data were reviewed retrospectively from 3291 colonoscopies performed on asymptomatic patients found to have an adenoma on screening with flexible sigmoidoscopy a few weeks before the colonoscopy or who had a family history of colorectal cancer.
  • All polyps were excised endoscopically and sent for pathology testing.
  • RESULTS: Of the 3291 colonoscopies performed, 1235 colonoscopies yielded a total of 1933 small or diminutive adenomatous polyps.
  • Of the 107 patients found to have polyps 2-10 mm with advanced histology, 100 (93%) were referred for colonoscopy because of an adenoma found on a recent screening with flexible sigmoidoscopy.
  • [MeSH-major] Adenomatous Polyps / pathology. Carcinoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Colonoscopy. Disease Progression. Female. Humans. Male. Middle Aged. Prevalence

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  • [CommentIn] Nat Clin Pract Gastroenterol Hepatol. 2006 Sep;3(9):488-9 [16951664.001]
  • [CommentIn] Clin Gastroenterol Hepatol. 2006 Mar;4(3):293-5 [16527690.001]
  • (PMID = 16527698.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Dixon A, Wurm P, Hart A, Robinson R: Distal adenomatous polyps are rare in patients with inflammatory bowel disease. Postgrad Med J; 2006 Jan;82(963):76-8
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  • [Title] Distal adenomatous polyps are rare in patients with inflammatory bowel disease.
  • OBJECTIVE: There is an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD).
  • RESULTS: Of 106 patients (61 male, 45 female, mean age of 59 years), 80 suffered from ulcerative colitis, 20 from Crohn's disease, and six from indeterminate colitis.
  • CONCLUSIONS: The results suggest that distal adenomatous polyps are rare in patients aged 55-64 years with IBD compared with a control population.
  • This supports the hypothesis that lesions other than polyps are important for the development of colorectal cancer in patients with IBD.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / etiology. Inflammatory Bowel Diseases / etiology

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  • (PMID = 16397087.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 4Q81I59GXC / Mesalamine; MRK240IY2L / Azathioprine
  • [Other-IDs] NLM/ PMC2563726
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11. Khatibzadeh N, Ziaee SA, Rahbar N, Molanie S, Arefian L, Fanaie SA: The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps. J Cancer Res Ther; 2005 Oct-Dec;1(4):204-7
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  • [Title] The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps.
  • BACKGROUND: The appropriate application of Endoscopic modalities for polypectomy depends on the likelihood that the adenoma in question harbors invasive cancer.
  • While prior studies have evaluated polyp size and morphology in assessing the risk of malignancy, in recent decay some authorities have paid more attention to dysplasia.
  • All in all, the relative risk of cancer based on polyp distribution in correlation with dysplasia has not been statistically studied which is done in our study.
  • METHODS AND MATERIALS: Between June 2001 and March 2004, the distribution of 130 adenomatous polyps was compared with synchronous invasive or in situ cancer.
  • Factors such as Patient age, Patients gender, location of lesion, size of polyp, histological subtype of adenoma on biopsy, degree of dysplasia, synchronous cancer, color of polyp, and number of polyps were included in the data collection.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17998654.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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12. Su YH, Wang M, Aiamkitsumrit B, Brenner DE, Block TM: Detection of a K-ras mutation in urine of patients with colorectal cancer. Cancer Biomark; 2005;1(2-3):177-82
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  • We further compared, in a blinded study, the frequency of detecting mutated K-ras sequence in DNA isolated from plasma and urine derived from individuals who have either a colorectal carcinoma (CRC), or adenomatous polyps that contain a mutation in codon 12 of the K-ras proto-oncogene.
  • There was an 83% concurrence of mutated DNA detected in urine and its corresponding disease tissue from the same individuals, when paired urine and tissue sections from 20 patients with either CRC or adenomatous polyps were analyzed for K-ras mutation.
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / urine. DNA / classification. DNA / urine. Humans. Mutation. Nucleic Acid Denaturation. Peptide Nucleic Acids. Polymerase Chain Reaction / methods

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  • (PMID = 17192038.001).
  • [ISSN] 1574-0153
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA86400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Peptide Nucleic Acids; 9007-49-2 / DNA; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Number-of-references] 19
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13. Odom SR, Duffy SD, Barone JE, Ghevariya V, McClane SJ: The rate of adenocarcinoma in endoscopically removed colorectal polyps. Am Surg; 2005 Dec;71(12):1024-6
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  • [Title] The rate of adenocarcinoma in endoscopically removed colorectal polyps.
  • The purpose of this study was to determine the rate of cancer in a modern series of colorectal polyps.
  • All pathology reports from colon and rectal polyps from 1999 to 2002 were reviewed.
  • Reports of bowel resections, cancer-free polyps, and polyp-free mucosal biopsies were excluded.
  • Polyps were grouped by size, and the rate of adenocarcinoma was determined. x2 was used for analysis.
  • A total of 4,443 polyps were found, of which 3,225 were adenomatous [2,883 (89.4%) tubular adenomas, 399 (9.3%) tubulo-villous adenomas, 32 (1.0%) villous adenomas, and 11 (0.3%) carcinomas].
  • The rate of adenocarcinoma by size was 0.07 per cent for polyps <1 cm, 2.41 per cent for polyps 1-2 cm, and 19.35 per cent for polyps >2 cm, representing significantly fewer cancers for each category of polyp size than the accepted standard.
  • The rate of carcinoma in colon polyps is much lower than previously thought and currently stated in many texts.
  • These data do not alter the recommendations for polyp removal, however, failure to retrieve a specimen in a polyp <1 cm in size is unlikely to have an adverse outcome because the chances of malignancy are very low.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 16447472.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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14. Freeman HJ: Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction. World J Gastroenterol; 2005 Sep 7;11(33):5245-7
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  • [Title] Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction.
  • Endoscopy showed a large polyp on a stalk, protruding through the pylorus into the duodenum causing intermittent gastric outlet obstruction.
  • While prolapsing gastric antral polyps are usually benign and hyperplastic, inflammatory or regenerative in type, excisional snare polypectomy here led to complete resolution of his symptoms, but showed a malignant polyp.
  • [MeSH-major] Adenomatous Polyps / complications. Adenomatous Polyps / surgery. Gastric Outlet Obstruction / etiology. Gastroscopy. Stomach Neoplasms / complications. Stomach Neoplasms / surgery

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  • (PMID = 16127764.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4320407
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15. Bresalier RS: Early detection of and screening for colorectal neoplasia. Gut Liver; 2009 Jun;3(2):69-80
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  • The long natural history of colorectal neoplasia affords the opportunity to use preventive measures to improve survival in this disease.
  • Currently screening for adenomatous polyps and early-stage cancers is the best methodology for improving survival.

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  • (PMID = 20431727.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852697
  • [Keywords] NOTNLM ; Adenoma / Colon cancer screening / Colonoscopy / Computed tomographic colonography / Fecal occult blood testing
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16. Jiménez-Heffernan JA, Tejerina E, de la Morena E, Sanz Ortega E: Gamna-Gandy bodies in an adenomatous colorectal polyp. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):876-7
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  • [Title] Gamna-Gandy bodies in an adenomatous colorectal polyp.
  • [MeSH-major] Colorectal Neoplasms / pathology. Minerals / analysis. Polyps / pathology

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  • (PMID = 21045462.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Minerals
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17. Ahmad I, Khan AA, Alam A, Butt AK, Shafqat F, Sarwar S: A study of colorectal polyps. J Coll Physicians Surg Pak; 2006 May;16(5):364-7
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  • [Title] A study of colorectal polyps.
  • OBJECTIVE: To determine various features of colorectal polyps and to evaluate the safety of colonoscopic polypectomy.
  • Polyps were evaluated in terms of size, site, number and histopathology.
  • Two hundred and sixty-four patients had juvenile polyps, 39 had adenomatous polyps, 39 hyperplastic polyps, 39 inflammatory polyps, 3 malignant polyps and 2 patients had familial polyposis.
  • Histopathological reports were not available in 7 patients.
  • Size of the polyps ranged from 0.3 cm to 3.0 cm.
  • CONCLUSION: Juvenile polyps were the commonest variety of polyps in our study.
  • [MeSH-major] Colonic Polyps

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  • (PMID = 16756784.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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18. Llor X, Pons E, Xicola RM, Castells A, Alenda C, Piñol V, Andreu M, Castellví-Bel S, Payá A, Jover R, Bessa X, Girós A, Roca A, Gassull MA, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association: Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway. Clin Cancer Res; 2005 Oct 15;11(20):7304-10
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  • Whereas it has been known that mismatch repair gene mutations are the underlying cause of HNPCC, an undetermined number of patients do not have these alterations.
  • RESULTS: Twenty-five patients (1.9%) fulfilled Amsterdam criteria of HNPCC but 15 (60%) of them did not have microsatellite instability and showed normal expression of MMR proteins.
  • Like unstable HNPCC patients, this group without mutator pathway alterations had a significant percentage of synchronous and metachronous adenomatous polyps and cancers.

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  • (PMID = 16243801.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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19. John BJ, Irukulla S, Pilgrim G, Swift I, Abulafi AM: Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital. Colorectal Dis; 2008 Nov;10(9):898-900
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  • [Title] Surveillance colonoscopies for colorectal polyps--too often, too many! An Audit at a Large District General Hospital.
  • INTRODUCTION: The British society of Gastroenterologists (BSG) have laid down guidelines for surveillance colonoscopies in patients with large bowel adenomatous polyps.
  • We audited our practice of polyp management and looked at guideline compliance amongst patients on our colonoscopic surveillance list.
  • METHOD: All patients undergoing adenoma surveillance and those with newly detected adenomas over a 2-month period were included in the first loop of the audit.
  • Amongst those on surveillance for polyps, compliance was ascertained as regards need for procedure and appropriateness of surveillance interval.
  • Of the patients on our colonoscopic waiting list for adenomatous polyps, 17.7% satisfied guidelines, 23.4% did not require any further surveillance and 58.9% were booked for a procedure earlier than recommended.
  • [MeSH-major] Colonic Polyps / surgery. Colonoscopy / utilization. Intestinal Polyps / surgery. Rectal Diseases / surgery

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  • (PMID = 19037930.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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20. Goldstein NS: Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol; 2006 Jan;125(1):132-45
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  • [Title] Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases.
  • Eight sessile serrated adenoma (SSA), right colon polypectomies with focal invasive adenocarcinoma or high-grade dysplasia were studied to identify features indicating a high risk of transformation and characterize the morphologic features of serrated dysplasia; 6 cases had invasive adenocarcinoma; 2 were high-grade dysplasia.
  • Mean polyp maximum dimension was 8.5 mm (range, 6-12 mm).
  • The majority of each polyp was nonmalignant SSA.
  • Small proximal SSAs can transform into adenocarcinoma without a component of adenomatous dysplasia.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Chromosomal Instability. Colonic Neoplasms / pathology. Microsatellite Repeats
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Aged. Aged, 80 and over. Carrier Proteins / analysis. Cell Transformation, Neoplastic / pathology. Colonic Polyps / pathology. Epithelium / pathology. Humans. Middle Aged. Nuclear Proteins / analysis

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  • (PMID = 16483002.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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21. Tsuda H, Kozu T, Iinuma G, Ohashi Y, Saito Y, Saito D, Akasu T, Alexander DB, Futakuchi M, Fukamachi K, Xu J, Kakizoe T, Iigo M: Cancer prevention by bovine lactoferrin: from animal studies to human trial. Biometals; 2010 Jun;23(3):399-409
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  • Administration of bovine lactoferrin (bLF) suppresses carcinogenesis in the colon and other organs of test animals, and recently it was shown that ingestion of bLF inhibits the growth of adenomatous polyps in human patients.

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  • (PMID = 20407806.001).
  • [ISSN] 1572-8773
  • [Journal-full-title] Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
  • [ISO-abbreviation] Biometals
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; EC 3.4.21.- / Lactoferrin
  • [Number-of-references] 64
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22. Mehl KA, Davis JM, Clements JM, Berger FG, Pena MM, Carson JA: Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice. J Appl Physiol (1985); 2005 Jun;98(6):2219-25
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  • [Title] Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice.
  • Moderate-intensity treadmill running can alter male Apc(Min/+) mouse polyp formation.
  • This purpose of this study was to examine whether exercise mode differentially affects Apc(Min/+) mouse intestinal polyp development in male and female mice.
  • Nine weeks of training decreased total intestinal polyps by 29% in male treadmill runners (66 +/- 9; P = 0.038) compared with male controls (93 +/- 7).
  • The number of large polyps (>/=1-mm diameter) were also reduced by 38% in male treadmill runners (49 +/- 6; P = 0.005) compared with male controls (79 +/- 6).
  • Treadmill running in female Apc(Min/+) mice and wheel running in both genders did not affect polyp number or size.
  • The crypt depth-to-villus height ratio in the intestine, an indirect marker of intestinal inflammation, decreased by 21 (P = 0.024) and 24% (P = 0.029), respectively, in male and female treadmill runners but not wheel runners.
  • Physical activity-induced attenuation of intestinal polyp number and size is dependent on exercise mode and differs between genders.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / deficiency. Exercise Therapy / methods. Intestinal Polyps / pathology. Intestinal Polyps / prevention & control. Motor Activity. Physical Conditioning, Animal / methods
  • [MeSH-minor] Animals. Body Weight. Female. Genetic Predisposition to Disease / prevention & control. Male. Mice. Mice, Inbred C57BL. Severity of Illness Index. Sex Factors. Treatment Outcome

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  • (PMID = 15894538.001).
  • [ISSN] 8750-7587
  • [Journal-full-title] Journal of applied physiology (Bethesda, Md. : 1985)
  • [ISO-abbreviation] J. Appl. Physiol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR 017698
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
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23. Wong NA, Hunt LP, Novelli MR, Shepherd NA, Warren BF: Observer agreement in the diagnosis of serrated polyps of the large bowel. Histopathology; 2009 Jul;55(1):63-6
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  • [Title] Observer agreement in the diagnosis of serrated polyps of the large bowel.
  • AIMS: To assess observer agreement in the diagnosis of colorectal serrated polyps, in particular, serrated adenomas and admixed polyps (i.e.
  • 'polyps with admixed hyperplastic and adenomatous glands').
  • METHODS AND RESULTS: Sixty cases of large bowel polyps were assessed by four specialist gastrointestinal histopathologists and allocated into one of five categories: serrated adenoma, hyperplastic polyp, conventional adenoma, admixed polyp, and other polyps with serration.
  • The kappa values for diagnosing serrated adenoma versus all other polyps, and admixed polyp versus all other polyps were 0.38 and 0.3, respectively.
  • CONCLUSIONS: Specialist gastrointestinal histopathologists show only moderate concordance when distinguishing between serrated colorectal polyps.
  • There is only fair interobserver agreement in the diagnosis of serrated adenomas and admixed polyps of the large bowel.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Colonic Polyps / diagnosis

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  • (PMID = 19614768.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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24. Pellisé M, Fernández-Esparrach G, Cárdenas A, Sendino O, Ricart E, Vaquero E, Gimeno-García AZ, de Miguel CR, Zabalza M, Ginès A, Piqué JM, Llach J, Castells A: Impact of wide-angle, high-definition endoscopy in the diagnosis of colorectal neoplasia: a randomized controlled trial. Gastroenterology; 2008 Oct;135(4):1062-8
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  • BACKGROUND & AIMS: It is essential to optimize standard colonoscopy technique to be able to increase polyp detection.
  • Morphology, size, location, and pathologic diagnosis of each polyp were recorded.
  • Pathology examination was feasible in 418 lesions (272 adenomas, 109 hyperplastic polyps, and 37 inflammatory lesions).
  • The per-patient basis analyses demonstrated that there were no differences between the 2 arms of the study in the detection rates of polyps (SC, 0.84 +/- 1.59; HDE, 0.83 +/- 1.30), adenomas (0.45 +/- 1.07 vs 0.43 +/- 0.87), small adenomas (0.22 +/- 0.71 vs 0.28 +/- 0.78), flat adenomas (0.30 +/- 0.91 vs 0.21 +/- 0.63), or hyperplastic polyps (0.16 +/- 0.50 vs 0.18 +/- 0.54).
  • CONCLUSION: HDE did not detect significantly more colorectal neoplasia than SC.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Endoscopy, Gastrointestinal / standards
  • [MeSH-minor] Adenoma / pathology. Adult. Aged. Female. Humans. Male. Middle Aged. Patient Selection. Reproducibility of Results

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  • [CommentIn] Gastroenterology. 2008 Oct;135(4):1035-7 [18786535.001]
  • (PMID = 18725223.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
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25. Miller HL, Mukherjee R, Tian J, Nagar AB: Colonoscopy surveillance after polypectomy may be extended beyond five years. J Clin Gastroenterol; 2010 Sep;44(8):e162-6
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  • We examined adenoma yield to identify factors that predict appropriate intervals for postpolypectomy surveillance greater than 5 years, including risk of advanced adenoma recurrence.
  • Multivariate logistic regression was used to identify variables that predict finding an adenoma on follow-up colonoscopy.
  • Irrespective of surveillance interval, adenoma incidence occurred in 116 patients (29.1%) with 25 (6%) having advanced adenomas.
  • Patients with nonadvanced adenomas on index colonoscopy had a similar risk of advanced adenoma on follow-up colonoscopy at 5 years versus 6 to 10 years, 5% versus 6.2% (P=0.39).
  • The risk of advanced adenoma at 5 and 6 to 10 years in patients with a negative index colonoscopy was 7% versus 3.6% (P=0.15).
  • Patients with an advanced adenoma at index colonoscopy had the highest rate of advanced adenoma detection at 5 years at 26%.
  • Proximal polyp location (odds ratio 12.4, confidence interval 2.7-56.7) predicted advanced adenoma occurrence at 5 years.
  • Patients with an index advanced adenoma are at highest risk for recurrent advanced adenoma and should have repeat colonoscopy before a 5 years interval.
  • [MeSH-major] Adenoma / prevention & control. Colonic Polyps / surgery. Colonoscopy / methods. Colorectal Neoplasms / prevention & control
  • [MeSH-minor] Adenomatous Polyps / surgery. Aged. Female. Follow-Up Studies. Humans. Logistic Models. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local. Retrospective Studies. Risk. Time Factors

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  • (PMID = 20628313.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Meyskens FL Jr, McLaren CE, Pelot D, Fujikawa-Brooks S, Carpenter PM, Hawk E, Kelloff G, Lawson MJ, Kidao J, McCracken J, Albers CG, Ahnen DJ, Turgeon DK, Goldschmid S, Lance P, Hagedorn CH, Gillen DL, Gerner EW: Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila); 2008 Jun;1(1):32-8
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  • Colorectal adenoma recurrence was compared among the groups with log-binomial regression.
  • Recurrent adenomatous polyps can be markedly reduced by a combination of low oral doses of DFMO and sulindac and with few side effects.

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  • (PMID = 18841250.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA059024; United States / NCI NIH HHS / CA / CA72008; United States / NCI NIH HHS / CA / P30 CA023074; None / None / / R01 CA123065-01A2; United States / NCI NIH HHS / CA / CA95060; United States / NCI NIH HHS / CA / P30 CA023074-209010; United States / NCI NIH HHS / CA / CA47396; United States / NCI NIH HHS / CN / N01 CN075019; United States / NCI NIH HHS / CA / R01 CA123065-01A2; None / None / / P30 CA023074-209010; United States / NCI NIH HHS / CA / CA88078; United States / NCI NIH HHS / CN / N01-CN75019; United States / NCI NIH HHS / CA / P50 CA095060; United States / NCI NIH HHS / CA / R01 CA123065; None / None / / P50 CA095060-05; United States / NCI NIH HHS / CA / CA59024; United States / NCI NIH HHS / CA / P01 CA072008; United States / NCI NIH HHS / CA / CA63640; United States / NCI NIH HHS / CA / P30 CA062203; United States / NCI NIH HHS / CA / R01 CA088078; United States / NCI NIH HHS / CA / P50 CA095060-05; United States / NCI NIH HHS / CA / R01 CA063640
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Placebos; 184SNS8VUH / Sulindac; ZQN1G5V6SR / Eflornithine
  • [Other-IDs] NLM/ NIHMS58572; NLM/ PMC2562024
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27. Schulmann K, Pox C, Tannapfel A, Schmiegel W: The patient with multiple intestinal polyps. Best Pract Res Clin Gastroenterol; 2007;21(3):409-26
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  • [Title] The patient with multiple intestinal polyps.
  • The management of patients with multiple intestinal polyps may be difficult and greatly depends on the correct classification.
  • Here we report the case of a difficult patient with severe gastric polyposis and we present a review of polyposis syndromes such as classical and attenuated familial adenomatous polyposis (FAP), MYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis as well as rare polyposis syndromes.
  • The most practical approach for the diagnostic workup in patients with newly diagnosed gastrointestinal polyposis is based on the histological typing of polyps.
  • In addition, a detailed family history regarding cancer, polyps and congenital abnormalities should be obtained from every polyposis patient.
  • Of these, younger age and higher polyp count are most likely a diagnosis of typical FAP.
  • Older age and fewer polyps favour a diagnosis of AFAP or MAP.
  • [MeSH-major] Intestinal Polyps / diagnosis

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  • (PMID = 17544108.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Powers HJ, Hill MH, Welfare M, Spiers A, Bal W, Russell J, Duckworth Y, Gibney E, Williams EA, Mathers JC: Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study). Cancer Epidemiol Biomarkers Prev; 2007 Oct;16(10):2128-35
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  • [Title] Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).
  • A double-blind randomized placebo-controlled intervention study (the FAB2 Study) was carried out in healthy controls and patients with colorectal polyps (adenomatous and hyperplastic) to examine effects of folic acid and riboflavin supplements on biomarkers of nutrient status and on putative biomarkers of colorectal cancer risk (DNA methylation and DNA damage; to be reported elsewhere).
  • Ninety-eight healthy controls and 106 patients with colorectal polyps were stratified for the thermolabile variant of methylene tetrahydrofolate reductase, MTHFR C677T, and were randomized to receive 400 microg of folic acid, 1,200 microg of folic acid, or 400 microg of folic acid plus 5 mg of riboflavin or placebo for 6 to 8 weeks.
  • Riboflavin supplement enhanced the response to low-dose folate in people carrying at least one T allele and having polyps.
  • The magnitude of the response in mucosal folate was positively related to the increase in plasma 5-methyl tetrahydrofolate but was not different between the healthy group and polyp patients.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Biomarkers, Tumor / blood. Folic Acid / administration & dosage. Folic Acid / blood. Riboflavin / administration & dosage. Riboflavin / blood

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  • (PMID = 17932361.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tetrahydrofolates; 0LVT1QZ0BA / Homocysteine; 134-35-0 / 5-methyltetrahydrofolate; 935E97BOY8 / Folic Acid; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); TLM2976OFR / Riboflavin
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29. Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, Dash C, Giardiello FM, Glick S, Levin TR, Pickhardt P, Rex DK, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory Group, US Multi-Society Task Force, American College of Radiology Colon Cancer Committee: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin; 2008 May-Jun;58(3):130-60
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  • [Title] Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology.
  • CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized.
  • In 2006 to 2007, the American Cancer Society, the US Multi Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults.
  • In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy.
  • When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps and a screening test that primarily is effective at early cancer detection.
  • [MeSH-major] Colonic Polyps / prevention & control. Colorectal Neoplasms / prevention & control. Mass Screening / standards


30. Suraweera N, Haines J, McCart A, Rogers P, Latchford A, Coster M, Polanco-Echeverry G, Guenther T, Wang J, Sieber O, Tomlinson I, Silver A: Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice. Hum Mol Genet; 2006 Dec 1;15(23):3429-35
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  • Min mice provide a good model of human familial adenomatous polyposis.
  • Recently, we have reported on two recombinant inbred lines (I and V) and the location of a modifier (Mom3) close to Apc, which altered polyp numbers in our mice possibly by modifying the frequency of wild-type (WT) allele loss at Apc; mice with severe disease (line V) showed elevated rates of loss.
  • We now show that in line I only, a single pregnancy caused a significant increase in adenoma multiplicity compared with virgin controls (P<0.001) and that an additional pregnancy conferred a similar risk.
  • Pregnancy was linked to both adenoma initiation and enhanced tumour growth in line I mice, and interline crosses indicated that susceptibility to pregnancy-associated adenomas was under genetic control.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Genes, APC. Genetic Predisposition to Disease. Pregnancy Complications, Neoplastic / genetics
  • [MeSH-minor] Animals. Chromosome Mapping. Disease Models, Animal. Female. Gene Frequency. Genetic Markers / genetics. Humans. Mice. Mice, Mutant Strains. Pregnancy. Receptors, Estrogen / genetics


31. Kim DW, Kim IJ, Kang HC, Jang SG, Kim K, Yoon HJ, Ahn SA, Han SY, Hong SH, Hwang JA, Sohn DK, Jeong SY, Choi HS, Hong CW, Lim SB, Park JG: Germline mutations of the MYH gene in Korean patients with multiple colorectal adenomas. Int J Colorectal Dis; 2007 Oct;22(10):1173-8
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  • The present study investigated germline mutations of the MYH gene among patients with 10 to 99 adenomatous colorectal polyps and familial adenomatous polyposis (FAP) without adenomatous polyposis coli (APC) germline mutations in Korea.
  • MATERIALS AND METHODS: The study population included 46 patients with 10 to 99 adenomatous polyps in the colorectum and 16 FAP patients with no identified APC germline mutations.
  • RESULTS: Two of 46 (4.3%) patients with multiple polyps displayed heterozygous biallelic germline mutations of the MYH gene.
  • A 39-year-old male patient with biallelic MYH mutations (p.G272E and p.A359V) received total proctocolectomy for rectal cancer and 36 colorectal polyps.
  • A 58-year-old female patient with biallelic MYH mutations (p.Q253X and p.Q440P) received right hemicolectomy for ascending colon cancer and 16 colonic polyps.
  • The frequency of biallelic MYH mutation in 14 of 46 multiple-polyp patients, who had 15 to 99 polyps, was 14.3% (2 of 14).
  • No biallelic MYH mutations were detected in the 32 patients with 10 to 14 colorectal polyps, 16 FAP patients, or 96 normal controls.
  • CONCLUSION: We identified biallelic MYH germline mutations in 2 of 14 (14.3%) Korean patients with 15 to 99 colorectal polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colonic Polyps / genetics. DNA Glycosylases / genetics. Mutation / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Asian Continental Ancestry Group. Base Sequence. Female. Genetic Predisposition to Disease / genetics. Humans. Male. Middle Aged

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  • (PMID = 17703316.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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32. Huang SC, Erdman SH: Pediatric juvenile polyposis syndromes: an update. Curr Gastroenterol Rep; 2009 Jun;11(3):211-9
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  • Colon polyps are a common finding in pediatrics and can present with rectal bleeding, abdominal pain, or polyp prolapse from the rectum.
  • Histologically classified as hamartomas, these isolated pediatric polyps lack epithelial dysplasia and have no cancer risk.
  • However, when polyps are present in greater numbers, or are associated with a family history of polyps or colon or other cancers, a polyposis or hereditary colorectal cancer syndrome should be considered.
  • Using a case-based format, this article reviews the clinical features and provides updates on the three most common hamartomatous polyp syndromes of childhood: juvenile polyposis syndrome, Peutz-Jeghers syndrome, and the PTEN hamartoma tumor syndrome.
  • Lifelong cancer surveillance is crucial to disease prevention and the long-term health of these patients and their families.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Genetic Predisposition to Disease. Hamartoma / diagnosis. Peutz-Jeghers Syndrome / diagnosis

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  • (PMID = 19463221.001).
  • [ISSN] 1534-312X
  • [Journal-full-title] Current gastroenterology reports
  • [ISO-abbreviation] Curr Gastroenterol Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / SMAD4 protein, human; 0 / Smad4 Protein; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / BMPR1A protein, human; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.1.3.67 / PTEN protein, human
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33. Lynch PM, Ayers GD, Hawk E, Richmond E, Eagle C, Woloj M, Church J, Hasson H, Patterson S, Half E, Burke CA: The safety and efficacy of celecoxib in children with familial adenomatous polyposis. Am J Gastroenterol; 2010 Jun;105(6):1437-43
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  • [Title] The safety and efficacy of celecoxib in children with familial adenomatous polyposis.
  • OBJECTIVES: Celecoxib is approved as an adjunctive chemopreventive agent in adults with familial adenomatous polyposis (FAP).
  • Its safety and efficacy for colorectal polyps in children is unknown.
  • Safety profile, difference in number, and percent change in colorectal polyps were compared among the four treatments (placebo and the three dose-escalation groups).
  • Median polyp count at baseline was 31.
  • There was a 39.1% increase in the number of polyps in placebo subjects at month 3, whereas in the highest dose celecoxib group, 16 mg/kg/day, a 44.2% reduction was seen (P=0.01).
  • CONCLUSIONS: Celecoxib at a dose of 16 mg/kg/day, corresponding to the adult dose of 400 mg BID, is safe, well tolerated, and significantly reduced the number of colorectal polyps in children with FAP.
  • [MeSH-major] Adenoma / prevention & control. Adenomatous Polyposis Coli / drug therapy. Colonic Neoplasms / prevention & control. Colonic Polyps / prevention & control. Cyclooxygenase 2 Inhibitors / therapeutic use. Pyrazoles / therapeutic use. Sulfonamides / therapeutic use

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  • (PMID = 20234350.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-05126-02
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib
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34. Park KJ, Choi HJ, Kim SH, Han SY, Hong SH, Cho JH, Kim HH: Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction. World J Gastroenterol; 2006 Jan 7;12(1):146-9
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  • [Title] Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction.
  • We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp.
  • An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum.
  • CT scan showed the typical finding of intussusception.
  • The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.
  • [MeSH-major] Adenoma / complications. Intussusception / surgery. Laparoscopy / methods. Rectal Diseases / surgery. Sigmoid Neoplasms / complications

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  • (PMID = 16440436.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4077479
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35. Groen EJ, Roos A, Muntinghe FL, Enting RH, de Vries J, Kleibeuker JH, Witjes MJ, Links TP, van Beek AP: Extra-intestinal manifestations of familial adenomatous polyposis. Ann Surg Oncol; 2008 Sep;15(9):2439-50
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  • [Title] Extra-intestinal manifestations of familial adenomatous polyposis.
  • Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene.
  • FAP is characterized by the formation of hundreds to thousands of colorectal adenomatous polyps.
  • This means, it is comparable to other diseases such as the MEN syndromes, Von Hippel-Lindau disease and neurofibromatosis.
  • Therefore, a specialized multidisciplinary approach to optimize health care-common for other disorders-is not usually taken for FAP patients.
  • FAP-related complications, for which medical attention is essential, are not rare and their estimated lifetime risk presumably exceeds 30%.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / genetics. Germ-Line Mutation. Humans

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  • (PMID = 18612695.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
  • [Number-of-references] 111
  • [Other-IDs] NLM/ PMC2518080
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36. Iaquinto G, Fornasarig M, Quaia M, Giardullo N, D'Onofrio V, Iaquinto S, Di Bella S, Cannizzaro R: Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis. Gastrointest Endosc; 2008 Jan;67(1):61-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis.
  • BACKGROUND: Duodenal cancer and ampullary cancer are major causes of death after a prophylactic colectomy in patients with familial adenomatous polyposis (FAP).
  • The study of polyps distal to the duodenum in FAP is limited.
  • OBJECTIVE: The objective was to detect whether CE has clinical value or any utility for the surveillance of small-bowel polyps in patients with FAP and to evaluate whether there are genotypic factors that predict which patients are at a lower risk of small-bowel polyps.
  • MAIN OUTCOME MEASUREMENTS: Patients with FAP were examined by CE to assess the location, size, and number of small-bowel polyps.
  • All patients were selected for mutation analysis, and the germline adenomatous polyposis coli (APC) gene mutation was detected.
  • RESULTS: Eleven of 23 patients with FAP had duodenal polyps.
  • During CE, jejunal-ileal polyps were detected in 7 of 23 FAPs, with a total number of 15 polyps in the ileum.
  • The presence of duodenal adenomas was the only clinical feature predictive of small-bowel polyps.
  • Identification of the ampulla of Vater was not achieved with CE; duodenal polyps were only seen in 4 of 11 patients identified endoscopically, with an underestimation of polyp numbers.
  • APC mutations between codons 499 and 805 were associated with the absence of small-bowel polyps.
  • CONCLUSIONS: CE is useful and safe for the surveillance of jejunal-ileal polyps in selected patients with FAP.
  • CE is not useful in the surveillance of the duodenum where the majority of small-bowel cancers occur.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Capsule Endoscopy


37. Gurudu SR, Heigh RI, De Petris G, Heigh EG, Leighton JA, Pasha SF, Malagon IB, Das A: Sessile serrated adenomas: demographic, endoscopic and pathological characteristics. World J Gastroenterol; 2010 Jul 21;16(27):3402-5
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  • AIM: To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma (SSA) in a single center.
  • A retrospective chart review was performed to extract data on demographics, polyp characteristics, presence of synchronous adenomatous polyps or cancer, polypectomy methods, and related complications.
  • The mean (SE) size of the SSAs was 8.1 (0.4) mm; 42% of SSAs were < or = 5 mm, and 69% were < or = 9 mm.
  • Approximately half of the patients had synchronous polyps of other histological types, including hyperplastic and adenomatous polyps.
  • Ninety-seven percent of polyps were removed by colonoscopy.
  • CONCLUSION: Among patients with colon polyps, 2.9% were found to have SSAs.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Polyps / pathology

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  • (PMID = 20632442.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2904886
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38. Colao A, Pivonello R, Auriemma RS, Galdiero M, Ferone D, Minuto F, Marzullo P, Lombardi G: The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients. J Clin Endocrinol Metab; 2007 Oct;92(10):3854-60
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  • OBJECTIVE: Our objective was to evaluate the role of fasting insulin levels on the prevalence of colonic adenomatous polyps or adenocarcinoma in acromegaly.
  • RESULTS: Colonic lesions were found in 81 patients (38.6%), and consisted of hyperplastic polyps in 33 (15.7%), adenomatous polyps in 42 (20.0%), and adenocarcinoma in six patients (2.8%).
  • Polyps were single in 22 cases (27.1%).
  • Fasting insulin levels were significantly lower in patients without lesions (16.0 +/- 7.5 mU/liter) than in patients with hyperplastic polyps (22.4 +/- 8.8 mU/liter; P < 0.01), adenomatous polyps (38.0 +/- 15.9 mU/liter; P < 0.0001), and adenocarcinoma (59.0 +/- 30.6 mU/liter; P < 0.0001).
  • Fasting insulin levels were also lower in patients with hyperplastic polyps than in those with adenomatous polyps (P < 0.01).
  • [MeSH-major] Acromegaly / epidemiology. Adenocarcinoma / epidemiology. Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Insulin / blood

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  • (PMID = 17652220.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I
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39. Byun TJ, Han DS, Ahn SB, Cho HS, Eun CS, Jeon YC, Sohn JH, Oh YH: Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer. Gut Liver; 2009 Jun;3(2):130-3
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  • [Title] Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer.
  • Pseudoinvasion or pseudocarcinomatous invasion in an adenomatous polyp of the colon can be unfamiliar to an endoscopist.
  • Pseudoinvasion in an adenomatous polyp represents prolapse of the adenomatous epithelium into its stalk.
  • In most cases its morphology does not differ from of general adenomatous polyps, but in some cases it can morphologically mimic a malignant polyp with submucosal invasion due to mass-like lesioning of its stalk.
  • This makes it difficult for endoscopists to differentiate pseudoinvasion in an adenoma from an invasive carcinoma by conventional endoscopy; instead, endoscopic ultrasonography can provide useful information for differentiating these conditions.
  • We report on an 82-year-old man who presented with a large pedunculated polyp with a thick stalk in the sigmoid colon, which mimicked a submucosal invasive carcinoma.
  • The patient was diagnosed with pseudoinvasion in an adenomatous polyp after segmental resection of the sigmoid colon.

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  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852693
  • [Keywords] NOTNLM ; Adenomatous polyps / EUS / Malignant polyp / Pseudoinvasion
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40. Leedham SJ, Wright NA: Expansion of a mutated clone: from stem cell to tumour. J Clin Pathol; 2008 Feb;61(2):164-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cancer is believed to be a disease of stem cells.
  • Work on the hereditary cancer syndromes, including familial adenomatous polyposis (FAP), has led to significant advances, including the adenoma-carcinoma sequence.
  • The initial mutation involved in this stepwise progression is in the "gatekeeper" tumour suppressor gene adenomatous polyposis coli (APC).
  • This model has been used to suggest that short-range interaction between adjacent initiated crypts, not random polyp collision, is responsible for tumour polyclonality.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Cell Transformation, Neoplastic / genetics. Gastrointestinal Tract / pathology. Neoplastic Stem Cells / pathology
  • [MeSH-minor] Disease Progression. Embryonal Carcinoma Stem Cells. Germ-Line Mutation. Humans. Stem Cells / cytology

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  • (PMID = 17468295.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G84/6549
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 66
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41. Summers RM, Yao J, Pickhardt PJ, Franaszek M, Bitter I, Brickman D, Krishna V, Choi JR: Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening population. Gastroenterology; 2005 Dec;129(6):1832-44
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  • [Title] Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening population.
  • BACKGROUND & AIMS: The sensitivity of computed tomographic (CT) virtual colonoscopy (CT colonography) for detecting polyps varies widely in recently reported large clinical trials.
  • Our objective was to determine whether a computer program is as sensitive as optical colonoscopy for the detection of adenomatous colonic polyps on CT virtual colonoscopy.
  • Our enhanced gold standard combined segmental unblinded optical colonoscopy and retrospective identification of precise polyp locations.
  • The data were randomized into separate training (n = 394) and test (n = 792) sets for analysis by a computer-aided polyp detection (CAD) program.
  • RESULTS: For the test set, per-polyp and per-patient sensitivities for CAD were both 89.3% (25/28; 95% confidence interval, 71.8%-97.7%) for detecting retrospectively identifiable adenomatous polyps at least 1 cm in size.
  • The false-positive rate was 2.1 (95% confidence interval, 2.0-2.2) false polyps per patient.
  • At both 8-mm and 10-mm adenoma size thresholds, the per-patient sensitivities of CAD were not significantly different from those of optical colonoscopy before segmental unblinding.

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  • (PMID = 16344052.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / CLC NIH HHS / CL / Z01 CL040003-03; United States / Intramural NIH HHS / /
  • [Publication-type] Comment; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS11760; NLM/ PMC1576342
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42. Kim BJ, Kim YH, Sinn DH, Kang KJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC: Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males. Cancer Causes Control; 2010 Jun;21(6):939-44
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  • [Title] Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males.
  • RESULTS: Subjects in their 50 s had significantly more adenomatous polyps than subjects in their 40 s (32.7% vs. 26.0%, p < 0.05).
  • The incidence of adenomatous polyp increased with increasing quartiles of HbA1C as follows: first quartile (19.9%, HbA1c 4.0-5.0), second quartile (27.8%, HbA1c 5.1-5.3), third quartile (32.7%, HbA1c 5.4-5.5), and fourth quartile (34.9%, HbA1c = 5.6-8.8)(p = 0.008).
  • When combining quartile of HbA1c and age (40 s vs. 50 s) according to HbA1C levels, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c <5.4% was significantly lower than that in subjects in their 50 s.
  • However, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c > or =5.4% was similar to that in subjects in their 50 s with average risk for CRC.
  • CONCLUSIONS: An elevated HbA1c may be useful as a clinical predictor of adenomatous polyps in male subjects <50 years of age who have average risk for CRC.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology

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  • (PMID = 20373014.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hemoglobin A, Glycosylated
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43. Tobi M, Kam M, Ullah N, Qureshi K, Yordanova V, Hatfield J, Fligiel SE, Sochacki P, McGarrity T, Cole C, Lawson M, Jacoby R: An anti-adenoma antibody, Adnab-9, may reflect the risk for neoplastic progression in familial hamartomatous polyposis syndromes. Dig Dis Sci; 2008 Mar;53(3):723-9
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  • [Title] An anti-adenoma antibody, Adnab-9, may reflect the risk for neoplastic progression in familial hamartomatous polyposis syndromes.
  • Patients with the hamartomatous polyposis Peutz-Jeghers and familial juvenile polyposis syndromes are predisposed to colorectal cancer but lack early genetic alterations found in adenomatous premalignant lesions.
  • We studied hamartomatous polyps for the expression of an early preneoplastic colorectal neoplasia risk marker also found in familial adenomatous polyposis patients.
  • Retrospective, genetic, and hospital archival tissue immunohistochemistry using Adnab-9, a premalignant marker often found in Paneth-like cells (PCs), was performed on sections of polyps from eight patients with Peutz-Jeghers syndrome, eight patients with familial juvenile polyposis, and 36 hyperplastic polyp control sections.
  • Eighty-nine percent of Peutz-Jeghers syndrome polyps labeled with Adnab-9 compared with 63% for AD5; 88% of familial juvenile polyposis sections also labeled with Adnab-9.
  • Of the 36 hyperplastic polyp sections, only four (11%) labeled with Adnab-9 and one (3%) with AD5.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Antibodies, Monoclonal. Biomarkers, Tumor. Colon / pathology. Colonic Polyps / pathology. Peutz-Jeghers Syndrome / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Child, Preschool. Disease Progression. Female. Humans. Immunohistochemistry. Infant. Male. Middle Aged. Neoplastic Processes. Protein-Serine-Threonine Kinases / genetics. alpha-Defensins / metabolism

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  • (PMID = 17934846.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adnab-9; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / alpha-Defensins; 0 / alpha-defensin 5, human; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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44. Shen R, Tao L, Xu Y, Chang S, Van Brocklyn J, Gao JX: Reversibility of aberrant global DNA and estrogen receptor-alpha gene methylation distinguishes colorectal precancer from cancer. Int J Clin Exp Pathol; 2009;2(1):21-33
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  • However, the significance of epigenetic changes for diagnosis and/or prognosis of colorectal cancer have not been established, although it has been extensively investigated.
  • Herein we show that global DNA hypomethylation and ER-alpha gene hypermethylation are progressively enhanced from hyperplastic polyps (HPs) --> adenomatous polyps (APs) --> adenomatous carcinoma (AdCa).
  • The aberrant methylation can be completely reversed in APs, but not in AdCa by a nonsteroidal anti-inflammatory drug (NSAID) celecoxib, which is a selective inhibitor of cyclooxygenase-2 (Cox-2), suggesting that the epigenetic alterations between colorectal precancer (AP) and cancer (AdCa) are fundamentally different in response to anti-cancer therapy.
  • In normal colorectal mucosa, while global DNA methylation was not affected by aging, ER-alpha gene methylation was significantly increased with aging.
  • However, this increase did not reach the level observed in colorectal APs.

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  • (PMID = 18830381.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; DNA methylation / Precancer / cancer progression / colorectal cancer / epigenetic / estrogen receptor-α / nonsteroidal anti-inflammatory drugs / tumor initiation
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45. Homa K, Brzosko M, Safranow K, Marlicz K: [Acceptance of screening colonoscopy in the prevention of colorectal cancer in relation to some demographic factors]. Pol Merkur Lekarski; 2005 Aug;19(110):179-82
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  • Identifying the influence of some demographic factors on the consent for colonoscopy and the efficacy of each source of information seems to be very important for the success of screening colonoscopy programme and therefore for discovering adenomatous polyps and colorectal cancer.

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  • (PMID = 16245428.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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46. Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK: Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis. Dis Colon Rectum; 2005 Apr;48(4):816-23
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  • [Title] Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
  • PURPOSE: In familial adenomatous polyposis, the long-term risk of pouch polyposis and potential for pouch cancer are unknown.
  • Our aim was to evaluate prospectively the prevalence, nature, and etiology of pouch ileal adenomas with that of nonpouch ileal adenomas in familial adenomatous polyposis.
  • METHODS: Sixty patients with familial adenomatous polyposis pouch, 47 familial adenomatous polyposis patients with ileorectal anastomosis, and 20 younger patients with familial adenomatous polyposis who had prophylactic colectomy were examined with videoendoscopy.
  • RESULTS: Adenomatous polyps were found in the pouches of 34 patients (57 percent).
  • A total of 362 polyps were identified (range, 0-50 per patient).
  • Most polyps were tubular adenomas with mild dysplasia, but 11 patients had more advanced histology, including two patients with large villous adenomas.
  • CONCLUSION: The risk of pouch cancer in familial adenomatous polyposis is unclear, but follow-up periods since surgery remain relatively short.
  • Long-term endoscopic surveillance of familial adenomatous polyposis pouches is thus recommended along with evaluation of potential therapeutic options for pouch adenomas.
  • [MeSH-major] Adenoma / epidemiology. Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / surgery. Colonic Pouches / pathology. Ileal Neoplasms / epidemiology. Proctocolectomy, Restorative


47. Pfeifer GK, Corleta O, Gus P: [Evaluation of computed tomographic colonography for detection of colorectal polyps]. Arq Gastroenterol; 2008 Oct-Dec;45(4):301-7
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  • [Title] [Evaluation of computed tomographic colonography for detection of colorectal polyps].
  • BACKGROUND: Computed tomographic colonography has been proposed for detection of colorectal polyps instead of colonoscopy in colorectal cancer screening programs.
  • AIM: To evaluate the performance of computed tomographic colonography in the detection of colorectal polyps with colonoscopy used as the gold standard.
  • Colonoscopy detected 85 polyps in 19 of 20 patients (95%).
  • All the observed polyps were successfully removed and examined histologically.
  • The radiological examination correctly identified 8 of 10 polyps 10 mm or more in diameter, 2 of 19 (18,2%) with 5-9 mm, and just 1 of 53 <5mm (9,1%).
  • Seventeen of the 43 adenomatous polyps were > or =5 mm.
  • CONCLUSION: For the detection of colorectal polyps, computed tomographic colonography seems to be useful only when the result is positive, as the negative results of this examination cannot eliminate the presence of these lesions.
  • [MeSH-major] Colonic Neoplasms / radiography. Colonic Polyps / radiography. Colonography, Computed Tomographic / standards. Colonoscopy / standards. Rectal Neoplasms / radiography
  • [MeSH-minor] Adenomatous Polyps / radiography. Adult. Aged. Female. Humans. Male. Middle Aged. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 19148358.001).
  • [ISSN] 1678-4219
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] por
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Brazil
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48. Matusiewicz M, Krzystek-Korpacka M, Diakowska D, Grabowski K, Augoff K, Blachut K, Paradowski L, Kustrzeba-Wojcicka I, Piast M, Banas T: Serum sulfatase activity is more elevated in colonic adenomas than cancers. Int J Colorectal Dis; 2008 Apr;23(4):383-7
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  • BACKGROUND AND AIMS: Elucidation of molecular basis of the adenomatous polyps (AP) and colorectal cancer (CRC) development is crucial for their prevention, early detection, and treatment.
  • The likelihood of elevated sulfatase activity is almost ten times higher in subjects with than without polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / enzymology. Colorectal Neoplasms / enzymology. Sulfotransferases / blood

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  • (PMID = 18193432.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.8.2.- / SULF1 protein, human; EC 2.8.2.- / Sulfotransferases
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49. Jameel JK, Pillinger SH, Moncur P, Tsai HH, Duthie GS: Endoscopic mucosal resection (EMR) in the management of large colo-rectal polyps. Colorectal Dis; 2006 Jul;8(6):497-500
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  • [Title] Endoscopic mucosal resection (EMR) in the management of large colo-rectal polyps.
  • PATIENTS AND METHODS: A review of a prospective database over a 3-year period identified 87 patients who underwent endoscopic polypectomy for polyps in sizes from 10 to 50 mm, performed by two experienced endoscopists.
  • Histologically these lesions were predominantly adenomatous polyps.
  • Although histological completeness of excision was not confirmed in 19 lesions, repeat colonoscopy confirmed successful excision.
  • CONCLUSION: Within our unit endoscopic mucosal resection appeared to be safe and effective procedure for resecting large colorectal polyps not suitable for conventional polypectomy.
  • [MeSH-major] Endoscopy, Gastrointestinal. Intestinal Polyps / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Aged. Aged, 80 and over. Colonic Polyps / surgery. Female. Humans. Intestinal Mucosa / surgery. Male. Middle Aged. Neoplasm Invasiveness. Rectal Diseases / surgery

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  • (PMID = 16784470.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Half E, Bercovich D, Rozen P: Familial adenomatous polyposis. Orphanet J Rare Dis; 2009;4:22
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  • [Title] Familial adenomatous polyposis.
  • Familial adenomatous polyposis (FAP) is characterized by the development of many tens to thousands of adenomas in the rectum and colon during the second decade of life.
  • Generally, cancers start to develop a decade after the appearance of the polyps.
  • A less aggressive variant of FAP, attenuated FAP (AFAP), is characterized by fewer colorectal adenomatous polyps (usually 10 to 100), later age of adenoma appearance and a lower cancer risk.
  • Classic FAP is inherited in an autosomal dominant manner and results from a germline mutation in the adenomatous polyposis (APC) gene.
  • Most patients (~70%) have a family history of colorectal polyps and cancer.
  • In a subset of individuals, a MUTYH mutation causes a recessively inherited polyposis condition, MUTYH-associated polyposis (MAP), which is characterized by a slightly increased risk of developing CRC and polyps/adenomas in both the upper and lower gastrointestinal tract.
  • Differential diagnoses include other disorders causing multiple polyps (such as Peutz-Jeghers syndrome, familial juvenile polyps or hyperplastic polyposis, hereditary mixed polyposis syndromes, and Lynch syndrome).
  • Patients with progressive tumors and unresectable disease may respond or stabilize with a combination of cytotoxic chemotherapy and surgery (when possible to perform).
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / pathology

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  • (PMID = 19822006.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 114
  • [Other-IDs] NLM/ PMC2772987
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51. Neklason DW, Stevens J, Boucher KM, Kerber RA, Matsunami N, Barlow J, Mineau G, Leppert MF, Burt RW: American founder mutation for attenuated familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2008 Jan;6(1):46-52
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  • [Title] American founder mutation for attenuated familial adenomatous polyposis.
  • BACKGROUND & AIMS: Specific mutations in the adenomatous polyposis coli (APC) gene can lead to an attenuated form of familial adenomatous polyposis (AFAP).
  • Although AFAP mutation carriers have a 69% risk of colorectal cancer by age 80, clinical recognition remains a challenge in some cases because they present with few colonic adenomas and are difficult to distinguish clinically from patients with sporadic polyps.
  • RESULTS: Two large AFAP kindreds with the identical APC disease-causing mutation (c.426_427delAT) were linked to a founding couple who came to America from England around 1630.
  • The data show that 36.6% of the mutation-positive family members have fewer than 10 colonic adenomatous polyps, and 3 (6.8%) of these individuals were diagnosed with colorectal cancer.
  • CONCLUSIONS: In view of the apparent age of this mutation, a notable fraction of both multiple-adenoma patients and perhaps even colon cancer cases in the United States could be related to this founder mutation.
  • The colon cancer risk associated with the mutation makes genetic testing of considerable importance in patients with a personal or family history of either colonic polyps or cancer at a young age.

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  • (PMID = 18063416.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CN / NCI-CN-67000; United States / NCI NIH HHS / CA / P01-CA073992; United States / NCI NIH HHS / CA / R01 CA040641-21; United States / NCI NIH HHS / CA / R01 CA040641; United States / NCI NIH HHS / CA / P01 CA073992-10; United States / NCI NIH HHS / CA / CA040641-21; United States / NCI NIH HHS / CN / N01 CN067000; United States / NCI NIH HHS / CA / R01-CA040641; United States / NCI NIH HHS / CA / P01 CA073992; United States / NCI NIH HHS / CA / CA073992-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS37623; NLM/ PMC2245898
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52. Rüschoff J, Aust D, Hartmann A: [Colorectal serrated adenoma: diagnostic criteria and clinical implications]. Verh Dtsch Ges Pathol; 2007;91:119-25
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  • [Title] [Colorectal serrated adenoma: diagnostic criteria and clinical implications].
  • More than 40 years ago Morson (1962) coined the paradigm that adenomas are the main precursors of colorectal carcinoma (CRC) whereas hyperplastic polyps are "non-neoplastic" lesions without cancer risk.
  • Later-on (1988) this was supported by Vogelstein's molecular adenoma-carcinoma progression model with APC mutations being a key-initiating molecular event (classic adenoma-carcinoma pathway).
  • It's the merit of Jass (1999) to demonstrate that carcinogenesis in sporadic MSI-positive CRC is associated with serrated polyps.
  • These polyps form the hallmark of a third "serrated (neoplasia) pathway" exhibiting a hyperplastic polyp-like morphology characterized by serrated crypt epithelium.
  • In contrast to adenomatous polyps with readily apparent cytological atypia (dysplasia) the feature of dysplasia in serrated polyps is architectural distortion.
  • Today four categories of serrated lesions can be delineated: (i) the most frequent classic hyperplastic polyp (HP, 80-90%), followed by (ii) sessile serrated adenoma (SSA, 15-20%) and (iii) by the rare traditional serrated adenoma (TSA, < 1%).
  • Whereas HPP are benign, SSA are probably slowly progressing lesions and TSA as well as SSA with APC-type adenomatous atypias (iv. mixed SSA) indicate increased cancer risk.
  • Molecularly serrated polyps seem to share a defect in apoptosis caused by either K-ras or BRAF gene mutation leading to CpG island methylation (CIMP) affecting MLHI (--> MSI type CRC) or non-MMR oncogenes (--> MSI-L or MSS type serrated CRC, Mäkinen 2007).
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology
  • [MeSH-minor] Colonic Polyps / pathology. Diagnosis, Differential. Genes, APC. Humans. Hyperplasia / pathology. Mutation


53. Kekilli M, Dagli U, Kalkan IH, Tunc B, Disibeyaz S, Ulker A, Sahin B: Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: a Turkish referral centre study. Scand J Gastroenterol; 2010 Apr;45(4):434-9
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  • OBJECTIVES: To determine the incidences of dysplasia, adenomatous polyp and colon cancer in patients with ulcerative colitis (UC) and to evaluate the risk factors.
  • In terms of localization, 80 patients (29.1%) had distal disease, 107 (38.9%) had left-sided disease and 88 (32.0%) had extensive colitis.
  • Adenomatous polyp was found in six patients (2.2%).
  • Five cases (83.3% of the polyps) were in the diseased segment and one case (16.7%) was in the non-diseased segment.
  • Adenomatous polyp was not found in cases with colon cancer.
  • The difference in rates may be explained by racial factors, specific environmental factors, intensive control of disease activity through medical therapy and effective colonoscopic surveillance programmes.
  • [MeSH-major] Colitis, Ulcerative / epidemiology. Colonic Polyps / epidemiology. Colorectal Neoplasms / epidemiology. Precancerous Conditions / epidemiology


54. Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE, Li M, Shyr Y, Zheng W: The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. Am J Clin Nutr; 2007 Sep;86(3):743-51
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  • BACKGROUND: Mean magnesium intake in the US population does not differ from that in East Asian populations with traditionally low risks of colorectal cancer and other chronic diseases, but the ratio of calcium to magnesium (Ca:Mg) intake is much higher in the US population.
  • OBJECTIVE: We aimed to test whether the association of colorectal polyps with intake of calcium, magnesium, or both and Thr1482Ile polymorphism in the TRPM7 gene is modified by the Ca:Mg intake.
  • DESIGN: Included in the study were a total of 688 adenoma cases, 210 hyperplastic polyp cases, and 1306 polyp-free controls from the Tennessee Colorectal Polyp Study.
  • RESULTS: We found that total magnesium consumption was linked to a significantly lower risk of colorectal adenoma, particularly in those subjects with a low Ca:Mg intake.
  • An inverse association trend was found for hyperplastic polyps.
  • We also found that the common Thr1482Ile polymorphism was associated with an elevated risk of both adenomatous and hyperplastic polyps.
  • Moreover, this polymorphism significantly interacted with the Ca:Mg intake in relation to both adenomatous and hyperplastic polyps.
  • The subjects who carried >or=1 1482Ile allele and who consumed diets with a high Ca:Mg intake were at a higher risk of adenoma (odds ratio: 1.60; 95% CI: 1.12, 2.29) and hyperplastic polyps (odds ratio: 1.85; 95% CI: 1.09, 3.14) than were the subjects who did not carry the polymorphism.

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  • (PMID = 17823441.001).
  • [ISSN] 0002-9165
  • [Journal-full-title] The American journal of clinical nutrition
  • [ISO-abbreviation] Am. J. Clin. Nutr.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / P50 CA 95103; United States / NCI NIH HHS / CA / R01 CA072784; United States / NCI NIH HHS / CA / R01 CA072784-05; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / R01 CA97386; United States / NCI NIH HHS / CA / CA072784-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary; 0 / TRPM Cation Channels; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / TRPM7 protein, human; I38ZP9992A / Magnesium
  • [Other-IDs] NLM/ NIHMS33891; NLM/ PMC2082111
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55. Stekrova J, Sulova M, Kebrdlova V, Zidkova K, Kotlas J, Ilencikova D, Vesela K, Kohoutova M: Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects. BMC Med Genet; 2007;8:16
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  • BACKGROUND: Germline mutations in the adenomatous polyposis gene (APC) result in familial adenomatous polyposis (FAP).
  • Typical FAP is characterized by hundreds to thousands of colorectal adenomatous polyps and by several extracolonic manifestations.
  • An attenuated form of polyposis (AFAP) is characterized by less than 100 adenomas and later onset of the disease.
  • In the patients with novel mutations, correlations of the mutation localization are discussed in context of the classical and/or attenuated phenotype of the disease.
  • Interfamilial and/or intrafamilial phenotype variability was also confirmed in some cases which did not fit well with predicted genotype-phenotype correlation.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Genes, APC. Germ-Line Mutation

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  • (PMID = 17411426.001).
  • [ISSN] 1471-2350
  • [Journal-full-title] BMC medical genetics
  • [ISO-abbreviation] BMC Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1853078
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56. Moreira LR, Schenka AA, Filho PL, Lima CS, Trevisan MA, Vassallo J: Comparison of blood neoangiogenesis and lymphatic vascularization in colorectal adenomas from patients with and without concomitant colorectal cancer. Braz J Med Biol Res; 2009 Jul;42(7):593-8
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  • Most colorectal carcinomas develop from adenomas (adenoma-carcinoma sequence) in a process due to accumulation of molecular genetic alterations.
  • About 5% of adenomatous polyps are expected to become malignant, but data on the differential angiogenic patterns of these lesions in patients with and without concomitant cancer are missing.
  • The aim of the present study is to compare the angiogenic and lymphatic patterns of adenomatous polyps from patients with and without sporadic cancer.
  • Thirty adenomatous polyps (15 from patients with another principal malignant lesion, and 15 from patients without cancer) were submitted to immunohistochemical staining for CD105 (marker for neoangiogenesis) and D2-40 (marker for lymphatic endothelium).

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  • (PMID = 19466284.001).
  • [ISSN] 1414-431X
  • [Journal-full-title] Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • [ISO-abbreviation] Braz. J. Med. Biol. Res.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD; 0 / Biomarkers; 0 / ENG protein, human; 0 / Receptors, Cell Surface; 0 / monoclonal antibody D2-40
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57. Marshall JR: Nutrition and colon cancer prevention. Curr Opin Clin Nutr Metab Care; 2009 Sep;12(5):539-43
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  • An exciting recent discovery is that the combination of diflouromethylornithine and sulindac substantially decreases adenomatous polyp recurrence.
  • Screening has an important role, although it will probably not eliminate all colon cancer.
  • Nutritional modification remains potentially valuable, although research has not yet identified the objects of nutritional intervention.

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  • (PMID = 19512917.001).
  • [ISSN] 1473-6519
  • [Journal-full-title] Current opinion in clinical nutrition and metabolic care
  • [ISO-abbreviation] Curr Opin Clin Nutr Metab Care
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 184SNS8VUH / Sulindac; R16CO5Y76E / Aspirin; ZQN1G5V6SR / Eflornithine
  • [Number-of-references] 41
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58. Li SC, Burgart L: Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps. Arch Pathol Lab Med; 2007 Mar;131(3):440-5
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  • [Title] Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps.
  • They share similar morphologic features with both the conventional adenoma and the hyperplastic polyp in a fashion that is different from a mixed adenoma and a hyperplastic polyp.
  • OBJECTIVE: To describe the histopathologic features of traditional serrated adenoma and sessile serrated adenoma and their comparison with traditional adenomas and hyperplastic polyp.
  • CONCLUSIONS: Both types of serrated adenomas, traditional serrated adenoma and sessile serrated adenoma, are morphologically distinct, clinically important entities, and they can be diagnosed accurately in routine practice.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17516746.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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59. Ross SA, Finley JW, Milner JA: Allyl sulfur compounds from garlic modulate aberrant crypt formation. J Nutr; 2006 Mar;136(3 Suppl):852S-854S
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  • Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer.
  • Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents.
  • [MeSH-minor] Adenoma / prevention & control. Animals. Disease Models, Animal. Rodentia. Sulfinic Acids / therapeutic use

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  • (PMID = 16484579.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Plant Extracts; 0 / Sulfinic Acids
  • [Number-of-references] 24
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60. Fostira F, Apessos A, Oikonomou E, Kouklis P, Baratsis S, Manifikos G, Andera L, Yannoukakos D, Pintzas A, Nasioulas G: Culture of primary epithelial adenoma cells from familial adenomatous polyposis patients. Anticancer Res; 2008 Mar-Apr;28(2A):843-6
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  • [Title] Culture of primary epithelial adenoma cells from familial adenomatous polyposis patients.
  • Familial adenomatous polyposis patients carry a germ line mutation in the APC gene leading to the development of thousands of polyps, which, if left untreated, lead to cancer.
  • Successful subculturing of the cell sheets took place only when dispase prepared in Ca2+ and Mg2+ free medium, was used to digest polyp tissue taken from FAP patients.
  • CONCLUSION: The protocol we developed here provides a means of preparing cell cultures from human colorectal adenomas, which aid in the research of the transition from adenoma to carcinoma.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyposis Coli / pathology. Cell Culture Techniques / methods. Epithelial Cells / pathology
  • [MeSH-minor] Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Humans. Phenotype


61. Cappell MS: Reducing the incidence and mortality of colon cancer: mass screening and colonoscopic polypectomy. Gastroenterol Clin North Am; 2008 Mar;37(1):129-60, vii-viii
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  • Most colon cancers arise from conventional adenomatous polyps (conventional adenoma-to-carcinoma sequence), while some colon cancers appear to arise from the recently recognized serrated adenomatous polyp (serrated adenoma-to-carcinoma theory).
  • A minimal colonoscopic withdrawal time of 6 minutes is important to maximize polyp detection at colonoscopy.
  • Chromoendoscopy is an experimental technique used to highlight abnormal colonic areas to identify neoplastic tissue and to potentially determine the histology of colonic polyps at colonoscopy based on superficial pit anatomy.


62. Alazmi W, Bustamante M, O'Loughlin C, Gonzalez J, Raskin JB: The association of Streptococcus bovis bacteremia and gastrointestinal diseases: a retrospective analysis. Dig Dis Sci; 2006 Apr;51(4):732-6
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  • However, SBB is also frequently associated with chronic liver disease and has been described with other gastrointestinal disorders.
  • The aim of the study was to evaluate the prevalence of gastrointestinal disease in patients with SBB.
  • Patients' clinical records were reviewed, with special focus on underlying gastrointestinal disease or other major comorbidities.
  • Nine adult patients (19%) had end-stage liver disease (five female).
  • Six patients had alcohol-induced liver disease (one with concomitant chronic hepatitis C), with the remaining three cases related to autoimmune hepatitis, primary biliary cirrhosis, and nonalcoholic steatohepatitis.
  • Colonic neoplasms (adenocarcinoma in 3 and adenomatous polyps in 3) were found in 6 of 10 adult patients in whom colonoscopic evaluation was performed.

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  • (PMID = 16614996.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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63. Lee SS, Park SH, Kim JK, Kim N, Lee J, Park BJ, Kim YJ, Lee MW, Kim AY, Ha HK: Panoramic endoluminal display with minimal image distortion using circumferential radial ray-casting for primary three-dimensional interpretation of CT colonography. Eur Radiol; 2009 Aug;19(8):1951-9
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  • Image distortion was compared between the band view and four other three-dimensional review modes using ten 10-mm and ten 20-mm electronically generated polyps.
  • Mean image distortion index values, in which 1 indicates no distortion and the larger value represents greater distortion, were significantly smaller with the band view (1.03 and 1.01 for 10-mm and 20-mm polyps, respectively) than with the filet view (1.65 and 1.55) or the virtual colon dissection (3.27 and 3.85) (P < or = 0.004).
  • The sensitivity and specificity for detecting adenomatous polyps > or = 6 mm did not differ, but the mean interpretation time was significantly shorter with the band view than with the conventional endoluminal view by 1.8 and 4.5 minutes in readers 1 and 2, respectively (P < 0.0001).

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  • [Cites] Radiol Clin North Am. 2007 Mar;45(2):347-59 [17502222.001]
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  • (PMID = 19290529.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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64. Bjelakovic G, Nagorni A, Nikolova D, Simonetti RG, Bjelakovic M, Gluud C: Meta-analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma. Aliment Pharmacol Ther; 2006 Jul 15;24(2):281-91
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  • [Title] Meta-analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma.
  • BACKGROUND: Colorectal cancer may be prevented by reducing the development of adenomatous polyps.
  • AIM: To assess the benefits and harms of antioxidant supplements in preventing colorectal adenoma.
  • Outcome measures were development of colorectal adenoma adverse events.
  • Antioxidant supplements seemed to increase the development of colorectal adenoma in three low-bias risk trials (1.2, 0.99-1.4) and significantly decrease its development in five high-bias risk trials (0.59, 0.47-0.74).
  • CONCLUSION: We found no convincing evidence that antioxidant supplements have significant beneficial effect on primary or secondary prevention of colorectal adenoma.

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  • (PMID = 16842454.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants
  • [Number-of-references] 68
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65. Stănciulea O, Preda C, Herlea V, Popa M, Ulmeanu D, Vasilescu C: [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis]. Chirurgia (Bucur); 2007 Mar-Apr;102(2):215-20
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  • [Title] [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis].
  • We present the case of a 52 years old man, with significant familial history, diagnosed with familial adenomatous polyposis-attenuated form, with no clinical and endoscopic surveillance until 2001 when he was admitted for an upper gastrointestinal haemorrhage episode.
  • Upper gastrointestinal scopy revealed duodenal adenomatous polyps and gastric hyperplastic polyps.
  • The histopathological exam revealed duodenal G2 adenocarcinoma pT3N0, and gastric hyperplastic polyps with no signs of dysplasia.
  • In 2002 the patient was admitted for rectal bleeding and colonoscopy showed 2 sigmoid polyps, appropriate for endoscopic removal and a poly-lobate polyp in the transverse colon.
  • March 2003--the patient underwent endoscopic removal for a rectal polyp (histopathological exam: moderate dysplasia).
  • The surgical procedure recommended in patients with attenuated form of familial adenomatous polyposis and suspect periampullary lesions is duodenopancreatectomy.
  • The particularity of the case is the association of total gastrectomy for gastric hyperplastic polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Carcinoma / surgery. Duodenal Neoplasms / surgery. Gastrectomy. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy / methods


66. Sangoi AR, Berry G: Respiratory epithelial adenomatoid hamartoma: diagnostic pitfalls with emphasis on differential diagnosis. Adv Anat Pathol; 2007 Jan;14(1):11-6
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  • In the upper aerodigestive tract, respiratory epithelial adenomatoid hamartoma (REAH) is described as a polypoid proliferation of glands lined by ciliated respiratory epithelium that seem to invaginate downward into the submucosa while maintaining direct continuity with the surface mucosa.
  • The lesion can be confused with a variety of benign and malignant entities, including inflammatory polyp, inverted schneiderian papilloma, and low-grade sinonasal adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenomatous Polyps / pathology. Biopsy. Diagnosis, Differential. Humans. Inflammation / pathology. Papilloma, Inverted / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 17198306.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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67. Niv Y, Vilkin A, Levi Z: Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study. J Clin Gastroenterol; 2010 Aug;44(7):489-94
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  • [Title] Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study.
  • We compared JCV antibody titers in patients with simple adenoma, advanced adenomatous polyp (AAP), CRC, and healthy controls, and evaluated JCV DNA in the tissue.
  • Normal colonoscopy, simple adenoma, AAP, and CRC were found in 41, 19, 12, and 25 cases, respectively.
  • The average titer for normal controls, simple polyp, AAP, and CRC was 2.61+/-0.72, 2.95+/-0.77, 3.33+/-0.76, and 3.30+/-0.50 log, respectively (P<0.001).
  • Viral DNA could not be shown in the serum.
  • The presence of neoplastic tissue T-Ag (in 33.3% of the patients) was not associated with a difference in the log titer of serum antibody.
  • If confirmed, our finding may serve as a marker for CRC or for an earlier stage of AAP.
  • [MeSH-major] Adenoma / virology. Adenomatous Polyps / virology. Colorectal Neoplasms / virology. JC Virus / immunology

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  • [CommentIn] J Clin Gastroenterol. 2010 Aug;44(7):466-8 [20520564.001]
  • (PMID = 20421810.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
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68. Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Reding DJ, Hayes RB, Church T, Yurgalevich S, Doria-Rose VP, Hickey T, Riley T, Berg CD: Utilization of surveillance colonoscopy in community practice. Gastroenterology; 2010 Jan;138(1):73-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND & AIMS: The recommended timing of surveillance colonoscopy for individuals with adenomatous polyps is based on adenoma histology, size, and number.
  • Subjects whose initial colonoscopy showed advanced adenoma (AA), nonadvanced adenoma (NAA), or no adenoma (NA) findings were included.
  • Incomplete colonoscopy, family history of colorectal cancer, or interval adenomatous findings could explain only a minority of surveillance colonoscopy in low-risk subjects.
  • [MeSH-major] Adenoma / epidemiology. Adenomatous Polyps / epidemiology. Colonic Neoplasms / epidemiology. Colonoscopy / utilization. Community Health Services / statistics & numerical data. Gastroenterology / statistics & numerical data

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  • [Copyright] Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 19818779.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000056-440770; United States / NCI NIH HHS / CN / N01-CN2551
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS151861; NLM/ PMC2813330
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69. Abrahamson PE, King IB, Ulrich CM, Rudolph RE, Irwin ML, Yasui Y, Surawicz C, Lampe JW, Lampe PD, Morgan A, Sorensen BE, Ayub K, Potter JD, McTiernan A: No effect of exercise on colon mucosal prostaglandin concentrations: a 12-month randomized controlled trial. Cancer Epidemiol Biomarkers Prev; 2007 Nov;16(11):2351-6
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  • RESULTS: Baseline colon prostaglandin E(2) and F(2alpha) concentrations were not correlated with age, race, education, family history of colon cancer, previous polyps, body size, diet, smoking, nonsteroidal antiinflammatory drug use, metabolic factors, or sex hormone levels.
  • Results were not modified by baseline age, body mass index, percentage of body fat, nonsteroidal antiinflammatory drug use, history of adenomatous polyps, or family history of colon cancer.
  • CONCLUSION: A 12-month moderate-to-vigorous intensity aerobic exercise intervention did not result in significant changes in colon mucosal prostaglandin concentrations.

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  • (PMID = 18006923.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG1094; United States / NCRR NIH HHS / RR / M01-RR-00037; United States / NCI NIH HHS / CA / R01 CA77572; United States / NCI NIH HHS / CA / R25 CA94880
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] B7IN85G1HY / Dinoprost; K7Q1JQR04M / Dinoprostone
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70. Abbass R, Rigaux J, Al-Kawas FH: Nonampullary duodenal polyps: characteristics and endoscopic management. Gastrointest Endosc; 2010 Apr;71(4):754-9
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  • [Title] Nonampullary duodenal polyps: characteristics and endoscopic management.
  • BACKGROUND: Guidelines for endoscopic resection and surveillance of nonampullary duodenal (NAD) polyps are still not well-defined.
  • OBJECTIVE: To describe the characteristics of NAD polyps and evaluate the role of endoscopic management.
  • PATIENTS: This study involved 59 patients with NAD polyps.
  • The mean (+/- standard deviation) polyp size was 17.2 mm +/- 1.6 mm.
  • Polyps of >2 cm were associated with higher rates of adenoma and a higher incidence of recurrence.
  • Not all patients underwent colonoscopy.
  • CONCLUSION: NAD polyps were large, sessile, and more commonly found in the second portion of the duodenum.
  • They are more likely to be adenomatous when the lesion size is >2 cm.
  • [MeSH-major] Duodenal Neoplasms / surgery. Duodenoscopy / methods. Intestinal Polyps / surgery
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Biopsy. Carcinoid Tumor / diagnosis. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Duodenum / pathology. Duodenum / surgery. Equipment Design. Follow-Up Studies. Humans. Hyperplasia. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Laser Therapy. Lasers, Gas. Lipoma / diagnosis. Lipoma / pathology. Lipoma / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Retrospective Studies

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20363416.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Li Q, Yang Z: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. J Exp Clin Cancer Res; 2009;28:65
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  • METHODS: Immunohistochemistry was used to detect and compare the frequency of p-ERK1/2 and PI3-K expression in gallbladder adenocarcinoma, peri-tumor tissues, adenomatous polyps, and chronic cholecystitis specimens.
  • RESULTS: The positive staining for p-EKR1/2 and PI3-K were 63/108 (58.3%) and 55/108 (50.9%) in gallbladder adenocarcinoma; 14/46 (30.4%) and 5/46 (10.1%) in peri-tumor tissues; 3/15 (20%) and 3/15 (20%) in adenomatous polyps; and 4/35 (11.4%) and 3/35 (8.6%) in chronic cholecystitis.
  • The positive rate of p-ERK1/2 or PI3-K in gallbladder adenocarcinoma was significantly higher than that in peri-tumor tissue (both, P < 0.01), adenomatous polyps (p-ERK1/2, P < 0.01; PI3-K, P < 0.05), and chronic cholecystitis (both, P < 0.01).
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / metabolism. Adenoma / pathology. Adenomatous Polyps / metabolism. Adenomatous Polyps / pathology. Adult. Female. Gallbladder / metabolism. Gallbladder / pathology. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Staging. Phosphorylation. Prognosis. Survival Rate

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  • (PMID = 19445727.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
  • [Other-IDs] NLM/ PMC2691734
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72. Sano Y, Ikematsu H, Fu KI, Emura F, Katagiri A, Horimatsu T, Kaneko K, Soetikno R, Yoshida S: Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps. Gastrointest Endosc; 2009 Feb;69(2):278-83
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  • [Title] Meshed capillary vessels by use of narrow-band imaging for differential diagnosis of small colorectal polyps.
  • BACKGROUND: Although microvascular vessels on the surface of colorectal polyps are observed by narrow-band imaging (NBI) with magnification, its clinical usefulness is still uncertain.
  • DESIGN: Prospective polyp study.
  • Patients with polyps >10 mm and those with polyps previously evaluated by histologic examination or colonoscopy were excluded.
  • INTERVENTION: Lesions were classified into 2 groups: polyps with invisible or faintly visible MC vessels as nonneoplastic and polyps with clearly visible MC vessels as neoplastic.
  • RESULTS: Of 92 eligible patients enrolled in this study, 150 lesions, including 39 (26%) hyperplastic polyps and 111 (74%) adenomatous polyps, were detected.
  • Observation of MC vessels detected 107 of 111 neoplastic polyps and 36 of 39 nonneoplastic polyps.
  • CONCLUSION: Observation of surface MC vessels by magnifying NBI is a useful and simple method for differentiating colorectal nonneoplastic and neoplastic polyps.
  • [MeSH-major] Capillaries / pathology. Colonic Polyps / pathology. Colonoscopy / methods

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  • (PMID = 18951131.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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73. Kil Lee S, Il Kim T, Kwan Shin S, Ho Kim W, Kim H, Kyu Kim N: Comparison of the clinicopathologic features between flat and polypoid adenoma. Scand J Gastroenterol; 2008;43(9):1116-21
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  • [Title] Comparison of the clinicopathologic features between flat and polypoid adenoma.
  • OBJECTIVE: Several reports have suggested that flat colorectal adenomas might exhibit a higher potential for malignancy compared to polypoid adenomas.
  • Although the clinical importance of the shape of polyps is stressed, the controversy surrounding the malignant potential of flat adenomas continues.
  • The aim of this study was to compare the clinicopathologic characteristics, including degree of dysplasia and malignancy, between flat and polypoid adenomas 5 mm in size or larger.
  • MATERIAL AND METHODS: A total of 3263 polyps (254 flat adenomas and 3009 polypoid adenomas), >/=5 mm in size, diagnosed in 1883 patients by colonoscopy were analyzed.
  • The flat adenomas were larger in diameter than the polypoid adenomas (14.8+/-12.6 mm versus 8.6+/-5.0 mm, p <0.01), had a higher rate of villous components (18.5% versus 11.4%, p <0.01), a higher rate of high-grade dysplasia (9.4% versus 4.2%, p <0.01), and a higher rate of malignancy (10.2% versus 3.6%, p <0.01) than polypoid adenomas.
  • However, there was no difference in the rate of high-grade dysplasia or carcinoma between flat and polypoid adenomas of equal size.
  • It was shown by multivariate analysis that rectosigmoid location, larger size, and presence of a villous component were associated with a higher rate of malignancy, but not with flat morphology.
  • CONCLUSIONS: Flat adenomas, which were of a relatively large size in this study, were not associated with a higher risk for high-grade dysplasia and carcinoma compared with polypoid adenomas.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 18609172.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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74. Wong RF, Tuteja AK, Haslem DS, Pappas L, Szabo A, Ogara MM, DiSario JA: Video capsule endoscopy compared with standard endoscopy for the evaluation of small-bowel polyps in persons with familial adenomatous polyposis (with video). Gastrointest Endosc; 2006 Oct;64(4):530-7
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  • [Title] Video capsule endoscopy compared with standard endoscopy for the evaluation of small-bowel polyps in persons with familial adenomatous polyposis (with video).
  • BACKGROUND: Video capsule endoscopy (VCE) may be useful for surveillance of small-bowel polyps in patients with familial adenomatous polyposis (FAP).
  • OBJECTIVE: To compare VCE to standard endoscopy for diagnosing small-bowel polyps in a defined segment of small bowel (proximal to a tattoo) and the entire examined small bowel.
  • The majority were selected for their high number of proximal small-bowel polyps and prior endoscopic tattoo placement in the proximal small bowel.
  • INTERVENTIONS: VCE (interpreted by 2 readers), push enteroscopy (PE), and lower endoscopy (LE) to count and measure small-bowel polyps.
  • RESULTS: In the defined segment, VCE detected a median of 10.0 (interquartile range [IQR], 5.0-19.0) and 9.0 (IQR, 6.0-16.0) polyps for each reader compared with a median of 41.0 (IQR, 19.0-64.0) polyps on PE (P = .002).
  • Agreement between VCE and PE was poor to fair (kappa = 0.10, 0.22) for estimating the size of the largest polyp and poor (kappa = -0.20, -0.27) for detecting large polyps (> or =1 cm).
  • In the entire examined small bowel, VCE diagnosed a median of 38.0 (IQR, 10.5-71.5) and 54.0 (IQR, 13.0-100.0) polyps for each reader compared with a median of 123.0 (IQR, 38.5-183.0) for combination endoscopy (PE and LE) (P < .001).
  • LIMITATIONS: Participants selected for high polyp burden, and results may not be applicable to all patients with FAP.
  • CONCLUSIONS: VCE underestimates the number of small-bowel polyps in persons with FAP and does not reliably detect large polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Capsule Endoscopy. Duodenal Neoplasms / diagnosis. Endoscopy, Gastrointestinal. Jejunal Neoplasms / diagnosis


75. Velmurugan B, Singh RP, Kaul N, Agarwal R, Agarwal C: Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice. Neoplasia; 2010 Jan;12(1):95-102
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  • At the end of the experiment, GSE feeding decreased the total number of intestinal polyps by 40%.
  • The decrease in polyp formation in the small intestine was 42%, which was mostly in its middle (51%) and distal (49%) portions compared with the proximal one.
  • GSE also decreased polyp growth where the number of polyps of 1 to 2 mm in size decreased by 42% and greater than 2 mm in size by 71%, without any significant change in polyps less than 1 mm in size.
  • Together, these findings show the chemopreventive potential of GSE against intestinal polyp formation and growth in APC(min/+) mice, which was accompanied with reduced cell proliferation and increased apoptosis together with down-regulation in COX-2, iNOS, beta-catenin, cyclin D1, and c-Myc expression, but increased Cip1/p21.

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  • (PMID = 20072658.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCCIH NIH HHS / AT / AT003623-03; United States / NCCIH NIH HHS / AT / R01 AT003623; United States / NCCIH NIH HHS / AT / R01 AT003623-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Cdkn1a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Myc protein, mouse; 0 / Plant Extracts; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-myc; 0 / beta Catenin; 136601-57-5 / Cyclin D1; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.13.39 / Nos2 protein, mouse; EC 1.14.99.- / Ptgs2 protein, mouse; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ PMC2805888
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76. Irabor DO, Arowolo A, Afolabi AA: Colon and rectal cancer in Ibadan, Nigeria: an update. Colorectal Dis; 2010 Jul;12(7 Online):e43-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To examine the incidence of this disease over 10 years in order to confirm or exclude the apparent significant increase in colorectal cancer cases in Ibadan, Nigeria.
  • CONCLUSION: Colorectal cancer is a disease on the increase in Ibadan.
  • Adenomatous polyps were absent in the resected specimens.

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  • (PMID = 19438886.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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77. Patel BB, Yu Y, Du J, Levi E, Phillip PA, Majumdar AP: Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: a risk factor for colon cancer. Biochem Biophys Res Commun; 2009 Jan 16;378(3):344-7
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  • The present study examines the presence of cancer stem-like cells (CSC) in adenomatous polyps and in normal appearing colonic mucosa in humans during aging.
  • The number of polyps was found to increase linearly with advancing age (r(2)=0.92, p<0.02).
  • Immunohistochemical analysis revealed co-localization of CSC markers CD44 and CD166 in colonic polyps.
  • Real-time RT-PCR analysis of normal appearing mucosa from subjects with adenomatous polyps showed an age-related rise in CSC as evidenced by the increased expression of CD44, CD166 and ESA.
  • In addition, the expression each CSC marker was found to be about 2-fold higher in subjects with 3-4 polyps than those with 1-2 polyps.
  • In conclusion, our results show that colon cancer stem-like cells are present in the premalignant adenomatous polyps as well in normal appearing colonic mucosa.

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  • (PMID = 19010307.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / AG014343; United States / NIA NIH HHS / AG / AG014343-11; United States / NIA NIH HHS / AG / R01 AG014343; United States / NIA NIH HHS / AG / R01 AG014343-11; United States / NIA NIH HHS / AG / R01 AG014343-10A1; United States / NIA NIH HHS / AG / AG014343-10A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALCAM protein, human; 0 / Antigens, CD; 0 / Antigens, CD44; 0 / Cell Adhesion Molecules, Neuronal; 0 / Fetal Proteins
  • [Other-IDs] NLM/ NIHMS89453; NLM/ PMC2644999
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78. Fang P, Qian F, Wu JZ: [Clinicopathological analysis of 39 patients with multiple primary synchronous colorectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Nov;10(6):535-9
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  • The incidence of adenomatous polyp in synchronous CRC was higher than that in single CRC(59.0% vs 25.0%,P<0.01).
  • CONCLUSIONS: Synchronous CRC and single CRC are not always similar in clinicopathologic characteristics and prognosis.
  • Early finding, early diagnosis and radical operation are the keys to improve the survival rate of synchronous CRC.

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  • (PMID = 18000774.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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79. Xu HX: Contrast-enhanced ultrasound in the biliary system: Potential uses and indications. World J Radiol; 2009 Dec 31;1(1):37-44
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  • The use of contrast-enhanced US (CEUS) has reached the field of bile duct disease in recent years and promising results have been achieved.
  • (4) To detect malignant change in Caroli's disease;.
  • (6) To make a distinction between gallbladder cholesterol polyp, adenoma and polypoid cancer;.

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  • (PMID = 21160719.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999303
  • [Keywords] NOTNLM ; Bile duct / Cholangiocarcinoma / Contrast-enhanced ultrasound / Gallbladder / Polypoid lesion / Ultrasound contrast agent
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80. Schreibman IR, Baker M, Amos C, McGarrity TJ: The hamartomatous polyposis syndromes: a clinical and molecular review. Am J Gastroenterol; 2005 Feb;100(2):476-90
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  • Familial adenomatous polyposis and hereditary nonpolyposis colon cancer are the two most common heritable colon cancer syndromes.
  • Inherited polyposis syndromes are characterized by the dominant type of polyp (whether adenomatous or hamartomatous) present and by the polyp's location within the gastrointestinal tract.
  • Hereditary mixed polyposis syndrome is a variant of juvenile polyposis characterized by both hamartomatous and adenomatous polyps.
  • The hamartomatous syndromes occur at approximately 1/10th the frequency of the adenomatous syndromes and account for <1% of colorectal cancer in Northern America.
  • [MeSH-major] Intestinal Polyps / genetics. Neoplastic Syndromes, Hereditary
  • [MeSH-minor] Abnormalities, Multiple. Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / genetics. Hamartoma Syndrome, Multiple / diagnosis. Hamartoma Syndrome, Multiple / genetics. Humans. Neurofibromatosis 1 / diagnosis. Neurofibromatosis 1 / genetics. Peutz-Jeghers Syndrome / diagnosis. Peutz-Jeghers Syndrome / genetics. Syndrome

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  • (PMID = 15667510.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 113
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81. Wassenaar MJ, Biermasz NR, Pereira AM, van der Klaauw AA, Smit JW, Roelfsema F, van der Straaten T, Cazemier M, Hommes DW, Kroon HM, Kloppenburg M, Guchelaar HJ, Romijn JA: The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly. J Clin Endocrinol Metab; 2009 Dec;94(12):4671-8
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  • METHODS: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients with long-term disease control and related to anthropometric parameters, cardiovascular risk factors, osteoarthritis, bone mineral density, colonic polyps and diverticulae, and dolichocolon.
  • Carriers of the d3GHR isoform showed increased prevalence of osteoarthritis, especially of the hip [adjusted odds ratio (OR), 5.2; 95% confidence interval (CI), 3.2-7.1], of adenomatous polyps (adjusted OR, 4.1; 95% CI, 2.4-5.6), and dolichocolon (adjusted OR, 3.2; 95% CI, 1.8-4.6).
  • Anthropometric parameters, cardiovascular risk factors, bone mineral density, and (non)vertebral fractures were not significantly different between patients with and without the d3GHR allele.
  • CONCLUSION: In patients with long-term cured acromegaly, the d3GHR polymorphism is associated with an increased prevalence of irreversible comorbidities such as osteoarthritis, dolichocolon, and adenomatous colonic polyps, but not with other comorbidities such as cardiovascular risk factors.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anthropometry. Bone Density / genetics. Bone Density / physiology. Cardiovascular Diseases / epidemiology. Cardiovascular Diseases / genetics. Cohort Studies. Colonic Diseases / epidemiology. Colonic Diseases / genetics. DNA / genetics. DNA / isolation & purification. Female. Gene Deletion. Genetic Predisposition to Disease. Human Growth Hormone / metabolism. Human Growth Hormone / physiology. Humans. Insulin-Like Growth Factor I / metabolism. Male. Middle Aged. Osteoarthritis / epidemiology. Osteoarthritis / genetics. Osteoarthritis / radiography. Osteoporosis / epidemiology. Osteoporosis / genetics. Risk Factors. Spinal Fractures / epidemiology. Spinal Fractures / genetics. Treatment Outcome

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  • (PMID = 19864451.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Somatotropin; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; 9007-49-2 / DNA
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82. Zhao C, Ivanov I, Dougherty ER, Hartman TJ, Lanza E, Bobe G, Colburn NH, Lupton JR, Davidson LA, Chapkin RS: Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prev Res (Phila); 2009 Jun;2(6):590-7
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  • For this purpose, the effects of a legume-enriched, low glycemic index, high fermentable fiber diet was evaluated in subjects with four possible combinations of risk factors, including insulin resistance and a history of adenomatous polyps.
  • Linear discriminant analysis was successfully used to identify the best single genes and two- to three-gene combinations for distinguishing subjects with insulin resistance, a history of polyps, or exposure to a chemoprotective legume-rich diet.

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  • (PMID = 19470793.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK071707-02; United States / NCI NIH HHS / CA / R01 CA129444-01; United States / NIDDK NIH HHS / DK / R01 DK071707-01A2; United States / NIDDK NIH HHS / DK / R01 DK071707-01A2S1; United States / NCI NIH HHS / CA / R01 CA059034-05; United States / NCI NIH HHS / CA / CA059034-12; United States / NCI NIH HHS / CA / CA059034-08; United States / NIEHS NIH HHS / ES / P30ES09106; United States / NCI NIH HHS / CA / R01 CA059034-07; United States / NCI NIH HHS / CA / CA059034-13; United States / NCI NIH HHS / CA / R01 CA059034; United States / NIDDK NIH HHS / DK / DK071707; United States / NCI NIH HHS / CA / R01 CA059034-15; United States / NCI NIH HHS / CA / R01 CA059034-11; United States / NCI NIH HHS / CA / CA059034-06; United States / NCI NIH HHS / CA / R01 CA059034-09; United States / NIDDK NIH HHS / DK / R01 DK071707-03; United States / NCI NIH HHS / CA / CA059034-09; United States / NIDDK NIH HHS / DK / DK071707-03; United States / NCI NIH HHS / CA / R01 CA129444-02; United States / NCI NIH HHS / CA / R01 CA059034-08; United States / NCI NIH HHS / CA / CA59034; United States / NCI NIH HHS / CA / CA059034-05; United States / NCI NIH HHS / CA / R01 CA059034-10; United States / NCI NIH HHS / CA / CA129444-01; United States / NCI NIH HHS / CA / CA059034-10; United States / NCI NIH HHS / CA / R01 CA059034-14; United States / NCI NIH HHS / CA / R01 CA059034-12; United States / NIDDK NIH HHS / DK / DK071707-01A2S1; United States / NIDDK NIH HHS / DK / DK071707-01A2; United States / NCI NIH HHS / CA / CA129444-02; United States / NCI NIH HHS / CA / CA059034-15; United States / NIDDK NIH HHS / DK / DK071707-02; United States / NCI NIH HHS / CA / CA059034-11; United States / NCI NIH HHS / CA / CA129444; United States / NCI NIH HHS / CA / CA059034-14; United States / NIDDK NIH HHS / DK / R01 DK071707; United States / NIEHS NIH HHS / ES / P30 ES009106; United States / NCI NIH HHS / CA / CA059034-07; United States / NCI NIH HHS / CA / R01 CA059034-06; United States / NCI NIH HHS / CA / R01 CA059034-13; United States / NCI NIH HHS / CA / R01 CA129444
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS120536; NLM/ PMC2745241
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83. Koffi B, Guillaudeau A, Delage-Corre M, Labrousse F, Paraf F: [Lipomatous polyposis of the colon: a case report]. Ann Pathol; 2009 Oct;29(5):421-3
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  • This affection is characterized by a great number of polyps which can reach several hundreds, of diffuse location on the entire length of the colon, with a higher density on the left colon and the sigmoid.
  • The size of polyps varies from 1 to 10 cm.
  • We report a case of colonic lipomatous polyposis, associated with an ileocolic lipomatous, an ileocolic diverticulosis and adenomatous polyps in a 70-year-old man.
  • [MeSH-major] Colonic Polyps / pathology. Intestinal Polyposis / pathology

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  • (PMID = 20004847.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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84. Fireman Z, Zachlka R, Abu Mouch S, Kopelman Y: The role of endoscopy in the evaluation of iron deficiency anemia in premenopausal women. Isr Med Assoc J; 2006 Feb;8(2):88-90
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  • METHODS: Upper and lower gastrointestinal endoscopic examinations were conducted in 45 premenopausal women with iron deficiency anemia not related to gynecologic or nutritional causes.
  • Twenty-eight upper gastrointestinal lesions were demonstrated in 24 of the 43 patients (55.8%): erosive gastritis in 12 (27.9%), erosive duodenitis in 4 (9.3%), erosive esophagitis in 3 (7.0%), hiatus hernia (with Cameron lesions) in 3 (7.0%), active duodenal ulcer in 1 (2.3%) and hyperplastic polyp (10 mm) in 1 (2.3%).
  • Five lower gastrointestinal lesions were detected in 5 patients (16.3%): 2 (4.6%) had adenocarcinoma of the right colon, 2 (4.6%) had pedunculate adenomatous polyp > 10 mm, and 1 (2.3%) had segmental colitis (Crohn's disease).
  • [MeSH-minor] Adolescent. Adult. Age Factors. Chronic Disease. Female. Humans. Middle Aged


85. Hayes SJ: Assessment of colorectal adenomatous polyp size measured during pathological examination highlights the importance of accuracy. Gastrointest Endosc; 2009 Sep;70(3):540-1
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  • [Title] Assessment of colorectal adenomatous polyp size measured during pathological examination highlights the importance of accuracy.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 19555943.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] United States
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86. Lam-Himlin D, Park JY, Cornish TC, Shi C, Montgomery E: Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol; 2010 Nov;34(11):1656-62
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  • [Title] Morphologic characterization of syndromic gastric polyps.
  • The morphology of gastric hamartomatous polyps from patients with juvenile polyposis syndrome (JuvPS) and Peutz-Jeghers' Syndrome (PJS) is poorly characterized.
  • We investigated the histologic features of gastric polyps in patients with established JuvPS or PJS to develop improved histologic criteria to distinguish these from gastric hyperplastic (HP) polyps.
  • All gastric polyps (n=30) from these patients were intermixed with gastric HP polyps from nonsyndromic patients (n=26) and subsequently blindly reviewed by a panel of gastrointestinal pathologists.
  • The panel then reviewed the slides in the context of clinical data and identified histologic features for distinguishing JuvPS, PJS, and HP gastric polyps based on epithelial changes, pit architecture, lamina propria features, and smooth muscle qualities.
  • On initial review, accuracy in diagnosis of gastric polyps in JuvPS was 50% and was 18% in PJS compared with 92% for HP gastric polyps.
  • Adherence to the recommended histologic criteria resulted in diagnostic accuracy of 41% for JuvPS and 54% for PJS, compared with 73% for HP gastric polyps.
  • The diagnostic accuracy based on polyp size was 59% for polyps which were less than equal to 3 mm, 56% for those 4 to 9 mm, and 81% for polyps which were more than equal to 10 mm.
  • The identification of gastric polyps from JuvPS and PJS patients without the context of clinical history of these syndromes remains poor, even with adherence to a set of morphologic criteria.
  • Abiding by such criteria improved recognition of PJS polyps by more than double (P<0.19), but yielded an accuracy of only 54%.
  • The accuracy did not improve when results were stratified for polyp location but did with biopsy size which were more than equal to10 mm.
  • Whereas these syndromic polyps are readily diagnosed in the small bowel and colon, histologic features to distinguish gastric JuvPS and PJS from gastric HP polyps are unreliable.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Gastric Mucosa / pathology. Hamartoma Syndrome, Multiple / diagnosis. Peutz-Jeghers Syndrome / diagnosis. Polyps / diagnosis. Stomach Diseases / diagnosis

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  • (PMID = 20924281.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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87. Yeruham I, Perl S, Lahav D: Anal adenomatous polyps in a crossbred beef cow. Vet Rec; 2005 Aug 13;157(7):204
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  • [Title] Anal adenomatous polyps in a crossbred beef cow.
  • [MeSH-major] Adenomatous Polyps / veterinary. Anus Neoplasms / veterinary. Cattle Diseases / pathology

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  • (PMID = 16100372.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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88. McKenzie S, Baek JH, Wakabayashi M, Garcia-Aguilar J, Pigazzi A: Totally laparoscopic right colectomy with transvaginal specimen extraction: the authors' initial institutional experience. Surg Endosc; 2010 Aug;24(8):2048-52
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  • A four-trocar laparoscopic right colectomy with intracorporeal anastomosis was performed for cancer in two cases and for adenomatous polyp in two cases.

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  • [CommentIn] Surg Endosc. 2011 May;25(5):1699-700 [20972582.001]
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  • (PMID = 20108143.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
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89. Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland CR, Matsubara N: Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer; 2008 Jun 1;122(11):2429-36
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  • Two methylation sensitive regions (Mp and Eh region) of MGMT promoter were investigated in 593 specimens of colorectal tissue: 233 CRCs, 104 adenomatous polyps (AP), 220 normal colonic mucosa from CRC patients (N-C) and 36 normal colonic mucosa specimens obtained from subjects without colorectal neoplasia (N-N) by combined bisulfite restriction analysis (COBRA).
  • Our data suggest that MGMT methylation may evolve and spread throughout the promoter in a stepwise manner as the colonic epithelial cells progress through the classical-adenoma-cancer multistep cascade.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18240147.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01-CA98572; United States / NCI NIH HHS / CA / R01 CA098572; United States / NCI NIH HHS / CA / R01-CA72851; United States / NCI NIH HHS / CA / R01 CA072851-13; United States / NCI NIH HHS / CA / R01 CA072851; United States / NCI NIH HHS / CA / R01 CA098572-05; United States / NCI NIH HHS / CA / CA098572-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 3.6.5.2 / ras Proteins; EC 6.5.1.- / DNA Repair Enzymes
  • [Other-IDs] NLM/ NIHMS187517; NLM/ PMC2851179
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90. Chakraborti AK, Garg SK, Kumar R, Motiwala HF, Jadhavar PS: Progress in COX-2 inhibitors: a journey so far. Curr Med Chem; 2010;17(15):1563-93
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  • Observation of increased cardiovascular risks in APPROVe (Adenomatous Polyp Prevention on Vioxx) study sent tremors and led to voluntary withdrawn of Vioxx (rofecoxib) by Merck from the market in September 2004 followed by Bextra (valdecoxib) in 2005 raising a question on the safety of selective COX-2 inhibitors.
  • Recognition of new avenues for selective COX-2 inhibitors such as cancer, Alzheimer's disease, Parkinson's disease, schizophrenia, major depression, ischemic brain injury and diabetic peripheral nephropathy has kindled the interest in these compounds.

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  • (PMID = 20166930.001).
  • [ISSN] 1875-533X
  • [Journal-full-title] Current medicinal chemistry
  • [ISO-abbreviation] Curr. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Heterocyclic Compounds; 0 / Lactones; 0 / Sulfones; 0 / lumiracoxib; 0QTW8Z7MCR / rofecoxib; 144O8QL0L1 / Diclofenac; EC 1.14.99.1 / Cyclooxygenase 2
  • [Number-of-references] 164
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91. Farrington SM, Tenesa A, Barnetson R, Wiltshire A, Prendergast J, Porteous M, Campbell H, Dunlop MG: Germline susceptibility to colorectal cancer due to base-excision repair gene defects. Am J Hum Genet; 2005 Jul;77(1):112-9
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  • Significantly more biallelic carriers had coexisting adenomatous polyps.
  • However, notably, 36% of biallelic carriers had no polyps.
  • [MeSH-minor] Cohort Studies. Disease Susceptibility. Heterozygote. Humans. Intestinal Polyps / genetics. Middle Aged. Penetrance. Population Surveillance

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  • [CommentIn] Am J Hum Genet. 2006 Oct;79(4):768-71; author reply 771-2 [16960817.001]
  • (PMID = 15931596.001).
  • [ISSN] 0002-9297
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U127527198
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC1226182
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92. Durno CA: Colonic polyps in children and adolescents. Can J Gastroenterol; 2007 Apr;21(4):233-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic polyps in children and adolescents.
  • Colonic polyps most commonly present with rectal bleeding in children.
  • The isolated juvenile polyp is the most frequent kind of polyp identified in children.
  • 'Juvenile' refers to the histological type of polyp and not the age of onset of the polyp.
  • Adolescents and adults with multiple juvenile polyps are at a significant risk of intestinal cancer.
  • Attenuated familial adenamatous polyposis (AFAP) can occur either by a mutation at the extreme ends of the adenomatous polyposis coli gene or by biallelic mutations in the mutY homologue (MYH) gene.
  • Colonic polyps, including isolated juvenile polyps, juvenile polyposis syndrome, FAP, AFAP and MYH-associated polyposis, are discussed in the present review.
  • [MeSH-major] Colonic Polyps
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / pathology. Adolescent. Child. DNA Glycosylases / genetics. Genes, APC. Genetic Counseling. Genetic Predisposition to Disease. Genetic Testing. Humans. Mutation

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  • (PMID = 17431512.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Number-of-references] 47
  • [Other-IDs] NLM/ PMC2657698
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93. Siddiqui AA, Kedika R, Mahgoub A, Patel M, Cipher DJ, Bapat V: A previous cholecystectomy increases the risk of developing advanced adenomas of the colon. South Med J; 2009 Nov;102(11):1111-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: There is limited data assessing the relationship between cholecystectomy and colorectal adenomatous polyps (AP).
  • Factors in each group associated with advanced AP were examined by univariate analysis (UA) and stepwise logistic regression analysis to determine independent predictors of aggressive clinical characteristics of polyps.
  • Statistical significance was determined at a P < or = 0.05.
  • By UA, those with a prior cholecystectomy had a greater mean number of AP (4.2 vs. 3.5; P = 0.04) and more advanced polyps (P = 0.037) than those without a cholecystectomy.
  • There appeared to be a trend towards increased time from cholecystectomy being associated with advanced polyps (9.69 years vs. 8.99 years, P = 0.056).
  • [MeSH-major] Adenoma / etiology. Cholecystectomy / adverse effects. Colonic Neoplasms / etiology
  • [MeSH-minor] Adenomatous Polyps / etiology. Analysis of Variance. Chi-Square Distribution. Humans. Logistic Models. Male. Middle Aged. Retrospective Studies. Risk Factors. Statistics, Nonparametric

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  • [CommentIn] South Med J. 2009 Nov;102(11):1098-9 [19864991.001]
  • (PMID = 19864992.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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94. Melstrom LG, Bentrem DJ, Salabat MR, Kennedy TJ, Ding XZ, Strouch M, Rao SM, Witt RC, Ternent CA, Talamonti MS, Bell RH, Adrian TA: Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clin Cancer Res; 2008 Oct 15;14(20):6525-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.
  • Many studies have examined the effects of COX inhibitors on human colorectal cancer, but the role of 5-LOX in colonic cancer development has not been well studied.
  • The purpose of this study was to evaluate the expression of 5-LOX in colonic polyps and cancer and the effect of 5-LOX inhibition on colon cancer cell proliferation.
  • EXPERIMENTAL DESIGN: Colonic polyps, cancer, and normal mucosa were evaluated for 5-LOX expression by immunohistochemistry.
  • RESULTS: 5-LOX is overexpressed in adenomatous polyps and cancer compared with that of normal colonic mucosa.
  • CONCLUSIONS: This study showed that 5-LOX is up-regulated in adenomatous colon polyps and cancer compared with normal colonic mucosa.
  • [MeSH-major] Arachidonate 5-Lipoxygenase / metabolism. Colonic Neoplasms / enzymology. Colonic Polyps / enzymology. Disease Models, Animal. Lipoxygenase Inhibitors / pharmacology
  • [MeSH-minor] Adenoma / drug therapy. Adenoma / enzymology. Adenoma / pathology. Animals. Apoptosis / drug effects. Cell Proliferation / drug effects. Female. Humans. Immunoenzyme Techniques. In Vitro Techniques. Masoprocol / therapeutic use. Mice. Mice, Inbred BALB C. Mice, Nude. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Thymidine / metabolism. Tumor Cells, Cultured. Xenograft Model Antitumor Assays

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  • (PMID = 18927292.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipoxygenase Inhibitors; 0 / RNA, Messenger; 7BO8G1BYQU / Masoprocol; EC 1.13.11.34 / Arachidonate 5-Lipoxygenase; VC2W18DGKR / Thymidine
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95. Holten-Andersen MN, Hansen U, Brünner N, Nielsen HJ, Illemann M, Nielsen BS: Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma. Int J Cancer; 2005 Jan 10;113(2):198-206
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  • [Title] Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma.
  • Combining TIMP-1 in situ hybridization with immunohistochemical staining for alpha-smooth muscle actin or CD68 showed TIMP-1 mRNA in myofibroblasts but not in macrophages.
  • TIMP-1 mRNA was detected in 2 of 7 adenomatous polyps in the adenoma area: in both cases associated with focal stromal inflammation at the epithelial-stromal interface.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenoma / genetics. Adenoma / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Tissue Inhibitor of Metalloproteinase-1 / biosynthesis. Tissue Inhibitor of Metalloproteinase-1 / pharmacology

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  • (PMID = 15386409.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tissue Inhibitor of Metalloproteinase-1
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96. Nielsen M, Franken PF, Reinards TH, Weiss MM, Wagner A, van der Klift H, Kloosterman S, Houwing-Duistermaat JJ, Aalfs CM, Ausems MG, Bröcker-Vriends AH, Gomez Garcia EB, Hoogerbrugge N, Menko FH, Sijmons RH, Verhoef S, Kuipers EJ, Morreau H, Breuning MH, Tops CM, Wijnen JT, Vasen HF, Fodde R, Hes FJ: Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP). J Med Genet; 2005 Sep;42(9):e54
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  • [Title] Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP).
  • No difference was found in the percentage of biallelic mutation carriers between patients with 10-99 polyps or 100-1000 polyps (29% in both groups).
  • Complete endoscopic reports were available for 16 MAP patients and revealed five cases with gastro-duodenal polyps (31%), one of whom also presented with a duodenal carcinoma.
  • CONCLUSIONS: Polyp numbers in MAP patients were equally associated with the attenuated and classical polyposis coli phenotypes.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Colorectal Neoplasms / genetics. DNA Mutational Analysis. Female. Genetic Predisposition to Disease. Genotype. Germ-Line Mutation. Humans. Inheritance Patterns / genetics. Male. Middle Aged. Netherlands. Phenotype. Risk

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  • (PMID = 16140997.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC1736132
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97. Li Q, Ishikawa TO, Oshima M, Taketo MM: The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res; 2005 Oct 1;65(19):8622-7
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  • [Title] The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.
  • The adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major negative controller of the Wnt/beta-catenin pathway.
  • Although both hypomorphic heterozygotes developed intestinal polyps, tumor multiplicities were much lower than that in Apc(Delta716) mice, heterozygotes of an Apc null allele.
  • Like in Apc(Delta716) mice, loss of the wild-type Apc allele was confirmed for all polyps examined in the Apc(neoR) and Apc(neoF) mice.
  • These results suggest that the reduced APC protein level increases intestinal polyp multiplicity through quantitative stimulation of the beta-catenin/T-cell factor transcription.
  • We further estimated the threshold of APC protein level that forms one polyp per mouse as approximately 15% of the wild type.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / metabolism. Genes, APC. Intestinal Neoplasms / genetics
  • [MeSH-minor] Alleles. Animals. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / metabolism. Cell Transformation, Neoplastic / pathology. Female. Intestinal Polyps / genetics. Intestinal Polyps / metabolism. Intestinal Polyps / pathology. Loss of Heterozygosity. Male. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. beta Catenin / metabolism

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  • (PMID = 16204028.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / beta Catenin
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98.