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Items 1 to 100 of about 677
1. Castillo-Alcala F, Mans C, Bos AS, Taylor WM, Smith DA: Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo). Can Vet J; 2010 Nov;51(11):1261-4
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and pathologic features of an adenomatous polyp of the colon in a domestic ferret (Mustela putorius furo).
  • The histopathological diagnosis of the resected mass was an adenomatous polyp of the colon.
  • [MeSH-major] Adenomatous Polyps / veterinary. Colonic Polyps / veterinary. Ferrets

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  • [Cites] J Am Anim Hosp Assoc. 1997 Mar-Apr;33(2):156-60 [9111726.001]
  • [Cites] J Am Vet Med Assoc. 1998 May 1;212(9):1402-6 [9589126.001]
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  • (PMID = 21286327.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal = La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2957035
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2. Byun TJ, Han DS, Ahn SB, Cho HS, Eun CS, Jeon YC, Sohn JH, Oh YH: Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer. Gut Liver; 2009 Jun;3(2):130-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer.
  • Pseudoinvasion or pseudocarcinomatous invasion in an adenomatous polyp of the colon can be unfamiliar to an endoscopist.
  • Pseudoinvasion in an adenomatous polyp represents prolapse of the adenomatous epithelium into its stalk.
  • In most cases its morphology does not differ from of general adenomatous polyps, but in some cases it can morphologically mimic a malignant polyp with submucosal invasion due to mass-like lesioning of its stalk.
  • This makes it difficult for endoscopists to differentiate pseudoinvasion in an adenoma from an invasive carcinoma by conventional endoscopy; instead, endoscopic ultrasonography can provide useful information for differentiating these conditions.
  • We report on an 82-year-old man who presented with a large pedunculated polyp with a thick stalk in the sigmoid colon, which mimicked a submucosal invasive carcinoma.
  • The patient was diagnosed with pseudoinvasion in an adenomatous polyp after segmental resection of the sigmoid colon.

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  • [Cites] J Clin Pathol. 1973 Jan;26(1):25-31 [4540378.001]
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  • (PMID = 20431736.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852693
  • [Keywords] NOTNLM ; Adenomatous polyps / EUS / Malignant polyp / Pseudoinvasion
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3. Liu DC, Yang ZL, Yang LP: [Expression of enhancer of zesle homolog 2 and phosphatase and tension homolog and its clinicopathological significance in benign and malignant lesion of gallbladder]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Jul;33(7):618-22
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  • METHODS: EnVision immunohistochemical method was used to detect the expressive levels of EZH2 and PTEN in routinely paraffin-embedded sections in the resected specimens of gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp(n = 15), and chronic cholecystitis (n = 35).
  • RESULTS: The positive rate of EZH2 was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues (chi(2) = 24.49, P < 0.01), adenomatous polyp(chi(2) = 11.68, P < 0.01), and chronic cholecystitis (chi(2) = 31.62, P < 0.01).
  • The positive rate of PTEN was significantly lower in gallbladder adenocarcinoma than that in peritumoral tissues(n = 20.20, P < 0.01), adenomatous polyp(chi(2)=10.81, P<0.01), and chronic cholecystitis (n = 29.83, P < 0.01).The positive rates of EZH2 were significantly lower in the highly-differentiated adenocarcinoma, the maximal diameter of mass < 2 cm, non-metastasis of lymphnodes, and non-infiltration of regional tissues than those in the moderately or low-differentiated adenocarcinoma, the maximal diameter > or = 2 cm, metastasis of lymphnode, and infiltration of regional tissues (P < 0.05 or P < 0.01).

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  • (PMID = 18667776.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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4. Gibson CJ, Parry NM, Jakowski RM, Cooper J: Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog. Vet Pathol; 2010 Jan;47(1):116-9
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  • [Title] Adenomatous polyp with intestinal metaplasia of the esophagus (Barrett esophagus) in a dog.
  • Endoscopically, the distal aspect of the esophagus was inflamed with a polypoid mass that protruded into the esophageal lumen.
  • This article reports a case of spontaneous esophageal adenomatous polyp with intestinal metaplasia (Barrett esophagus) and reviews the pathogenesis of esophageal metaplasia and adenocarcinoma.
  • [MeSH-major] Adenomatous Polyps / veterinary. Barrett Esophagus / veterinary. Dog Diseases / pathology. Esophageal Neoplasms / veterinary. Intestines / pathology

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  • (PMID = 20080491.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Chen YY, Soon MS, Yen HH: Gastrointestinal: Adenomatous polyp of the appendix. J Gastroenterol Hepatol; 2006 Mar;21(3):617

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal: Adenomatous polyp of the appendix.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Appendiceal Neoplasms / diagnosis

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  • (PMID = 16638109.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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6. Puppa G, Colombari R: Brown colon (melanosis coli) harbouring pale tumors (adenocarcinoma and an adenomatous polyp). J Gastrointestin Liver Dis; 2009 Dec;18(4):509-11
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  • [Title] Brown colon (melanosis coli) harbouring pale tumors (adenocarcinoma and an adenomatous polyp).
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatous Polyps / pathology. Colonic Diseases / pathology. Colonic Neoplasms / pathology. Melanosis / pathology

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  • (PMID = 20076832.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Romania
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7. Palanivelu C, Rangarajan M, Jategaonkar PA, Annapoorni S, Prasad H: Laparoscopic antrectomy for a proximal duodenal Brunner gland hamartoma. JSLS; 2009 Jan-Mar;13(1):110-5
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  • BACKGROUND: Adenoma is the most common cause of duodenal polyps, while hamartomas are very rare.
  • We present a patient with a preoperative histology proved diagnosis of isolated duodenal tubulovillous adenomatous polyp with high-grade dysplasia for whom we performed laparoscopic antrectomy.
  • Histopathology documented an adenomatous polyp with high-grade dysplasia, so a laparoscopic antrectomy was performed.
  • DISCUSSION: Many procedures have been described for polyps, such as endoscopic excision, duodenectomy, pancreatoduodenectomy, and laparoscopic polyp excision.
  • In our patient, the decision to perform duodenectomy was based on the preoperative findings of a sessile tubulovillous adenomatous polyp with high-grade dysplasia.

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  • (PMID = 19366555.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3015908
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8. Cantwell MM, Forman MR, Albert PS, Snyder K, Schatzkin A, Lanza E, Polyp Prevention Trial Study Group: No association between fatty acid intake and adenomatous polyp recurrence in the polyp prevention trial. Cancer Epidemiol Biomarkers Prev; 2005 Aug;14(8):2059-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] No association between fatty acid intake and adenomatous polyp recurrence in the polyp prevention trial.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Colorectal Neoplasms / prevention & control. Dietary Fats / therapeutic use. Fatty Acids / therapeutic use

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  • (PMID = 16103463.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats; 0 / Fatty Acids
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9. Lieberman D: Eighty-year-old patient with history of a twelve millimeter adenomatous polyp resected at age of seventy-five years. Clin Gastroenterol Hepatol; 2007 Feb;5(2):166-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eighty-year-old patient with history of a twelve millimeter adenomatous polyp resected at age of seventy-five years.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis

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  • (PMID = 17296526.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Pickhardt PJ, Choi JR: Adenomatous polyp obscured by small-caliber rectal catheter at low-dose CT colonography: a rare diagnostic pitfall. AJR Am J Roentgenol; 2005 May;184(5):1581-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatous polyp obscured by small-caliber rectal catheter at low-dose CT colonography: a rare diagnostic pitfall.
  • [MeSH-major] Adenomatous Polyps / radiography. Colonic Polyps / radiography. Colonography, Computed Tomographic / instrumentation

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  • (PMID = 15855119.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Niv Y, Vilkin A, Levi Z: Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study. J Clin Gastroenterol; 2010 Aug;44(7):489-94
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patients with sporadic colorectal cancer or advanced adenomatous polyp have elevated anti-JC virus antibody titer in comparison with healthy controls: a cross-sectional study.
  • We compared JCV antibody titers in patients with simple adenoma, advanced adenomatous polyp (AAP), CRC, and healthy controls, and evaluated JCV DNA in the tissue.
  • Normal colonoscopy, simple adenoma, AAP, and CRC were found in 41, 19, 12, and 25 cases, respectively.
  • The average titer for normal controls, simple polyp, AAP, and CRC was 2.61+/-0.72, 2.95+/-0.77, 3.33+/-0.76, and 3.30+/-0.50 log, respectively (P<0.001).
  • Viral DNA could not be shown in the serum.
  • The presence of neoplastic tissue T-Ag (in 33.3% of the patients) was not associated with a difference in the log titer of serum antibody.
  • If confirmed, our finding may serve as a marker for CRC or for an earlier stage of AAP.
  • [MeSH-major] Adenoma / virology. Adenomatous Polyps / virology. Colorectal Neoplasms / virology. JC Virus / immunology

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  • [CommentIn] J Clin Gastroenterol. 2010 Aug;44(7):466-8 [20520564.001]
  • (PMID = 20421810.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, Viral, Tumor; 0 / DNA, Viral
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12. Kalafatis P, Zougkas K: Adenomatous polyp of the verumontanum accompanied by parabulbous epidermoid cyst and cryptorchidism in an adult male. Urol Int; 2006;77(2):187-9
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  • [Title] Adenomatous polyp of the verumontanum accompanied by parabulbous epidermoid cyst and cryptorchidism in an adult male.
  • The coexistence of polyp of the verumontanum, epidermoid paraurethral cyst and cryptorchidism presents a mosaic of congenital anomalies of the urogenital tract.
  • Transurethral resection of the urethral polyp with a simultaneous excision of the cystic formation via a perineal approach followed by a left-sided funiculolysis and orchiopexy were performed.
  • [MeSH-major] Adenomatous Polyps / complications. Cryptorchidism / complications. Epidermal Cyst / complications. Urethral Diseases / complications. Urethral Neoplasms / complications

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  • (PMID = 16888430.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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13. Parker-Ray N, Barakat J, Roy PK, White RE, Schrader RM, Hoffman RM: Statin use does not prevent recurrent adenomatous polyp formation in a VA population. Indian J Gastroenterol; 2010 Jun;29(3):106-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Statin use does not prevent recurrent adenomatous polyp formation in a VA population.
  • PURPOSE: To evaluate whether statin use was associated with recurrent adenomatous polyps.
  • During follow-up, 88 (47%) of patients received statins, but use was not protective against recurrent adenomas (hazard ratio = 1.36, 95% CI 0.35-8.27).
  • Only number of polyps at initial colonoscopy predicted recurrent adenomas (1.98, 95% CI 1.27-3.08).
  • CONCLUSIONS: The use of statins was not protective against the recurrence of adenomatous polyps.
  • [MeSH-major] Adenomatous Polyposis Coli / prevention & control. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. Neoplasm Recurrence, Local / prevention & control. Veterans

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  • (PMID = 20658327.001).
  • [ISSN] 0975-0711
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors
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14. Ciurea S, Matei E, Petrisor P, Luca L, Boros M, Herlea V, Popescu I: Gallbladder adenoma with focal adenocarcinoma. Chirurgia (Bucur); 2008 May-Jun;103(3):355-8
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  • [Title] Gallbladder adenoma with focal adenocarcinoma.
  • The majority of polypoid lesions of the gallbladder are cholesterolosis pseudopolyps.
  • True neoplastic GB polyps are represented mainly by adenomas.
  • The case of a 52-year old male patient with an adenomatous polyp of the GB with focal adenocarcinoma is presented.
  • [MeSH-major] Adenocarcinoma. Adenoma. Gallbladder Neoplasms. Neoplasms, Multiple Primary

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  • (PMID = 18717288.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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15. Figer A, Shacham-Shmueli E, Liberman E, Sagiv E, Hall MJ, Dolkart O, Kazanov D, Kraus S, Neugut AI, Inbar M, Arber N: Effect of the I1307K polymorphism in APC confers a higher risk for polyp recurrence in Jewish Ashkenazi carriers. J Clin Oncol; 2009 May 20;27(15_suppl):e22003

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of the I1307K polymorphism in APC confers a higher risk for polyp recurrence in Jewish Ashkenazi carriers.
  • : e22003 Background: The I1307K adenomatous polyposis coli gene variant, prevalent among Ashkenazi Jews, may increase risk for colorectal neoplasia [colorectal cancer (CRC) and CR adenoma].
  • The histopathological features of adenomas and cancers did not differ between carriers and non-carriers.
  • CONCLUSIONS: In the general population, the APC I1307K variant does not change the risk or prognosis of colorectal neoplasia in carriers and does not necessarily change their clinical practice.
  • Nevertheless, the variant, which is more prevalent among high risk individuals of Ashkenazi Jewish origin, is an important risk factor for the assessment of recurrence of neoplasia as it confers a higher risk for polyp recurrence in this population.

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  • (PMID = 27963171.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Groisman GM, Amar M, Meir A: Utility of MIB-1 (Ki-67) in evaluating diminutive colorectal polyps with cautery artifact. Arch Pathol Lab Med; 2007 Jul;131(7):1089-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Utility of MIB-1 (Ki-67) in evaluating diminutive colorectal polyps with cautery artifact.
  • CONTEXT: Accurate interpretation of colorectal polyp histology is essential in the decision-making process during treatment and surveillance following polypectomies.
  • However, interpretation of diminutive colorectal polyps removed by thermal electrocoagulation (hot biopsy technique) is often problematic as a result of cautery artifact.
  • OBJECTIVE: To evaluated the usefulness of the proliferation marker MIB-1 (Ki-67) as an aid in the differential diagnosis of diminutive colorectal polyps with cautery artifact, as adenomatous and nonadenomatous polyps display different patterns of epithelial proliferation.
  • DESIGN: Seventy-five diminutive colorectal polyps with extensive cautery artifact displaying at least the upper portions of 3 adjacent crypts with the corresponding surface epithelium were evaluated and immunolabeled with MIB-1.
  • They included 25 cases in which a definitive or presumptive diagnosis could not be reached (indeterminate polyps), 25 cases diagnosed as compatible with adenomatous polyp, and 25 cases diagnosed as compatible with nonadenomatous polyp.
  • Among indeterminate polyps, MIB-1 stained upper crypts and surface epithelium in 14 cases (adenomatous polyp staining pattern) and revealed minimal or absent staining in these areas in 11 cases (nonadenomatous polyp staining pattern).
  • All cases diagnosed as compatible with adenomatous polyp displayed the adenomatous polyp staining pattern.
  • In contrast, all cases diagnosed as compatible with nonadenomatous polyp revealed the nonadenomatous polyp staining pattern.
  • CONCLUSIONS: Immunoreactivity for MIB-1 may be used as a beneficial adjunctive test to help diagnose diminutive colorectal polyps with extensive cautery artifact.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Intestinal Polyps / diagnosis. Ki-67 Antigen / analysis. Rectal Diseases / diagnosis

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  • (PMID = 17616996.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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17. Parra V, Watanabe J, Nago A, Astete M, Rodríguez C, Valladares G, Nuñez N, Yoza M, Gargurevich T, Pinto Sánchez J: [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy]. Rev Gastroenterol Peru; 2009 Oct-Dec;29(4):326-31
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  • [Title] [Role of the endoscopist in the detection of adenomatous polyps during colonoscopy].
  • [Transliterated title] Papel del Endoscopista en la Detección de Pólipos Adenomatosos Durante la Colonoscopia.
  • INTRODUCTION: Age, gender and indication for the examination are known predictors of adenomatous polyp detection during colonoscopy.
  • OBJECTIVES: To determine the role of the endoscopist in detecting adenomatous polyps during colonoscopy MATERIAL AND METHODS: Is retrospective cross-sectional correlational study.
  • Statistical analysis showed significant differences between endoscopists regarding the detection rate of adenomatous polyps (p = 0.038).
  • The range for the detection of at least 1 adenomatous polyp by colonoscopy was 14,6-30,0%.
  • In patients over 50 years, there were also significant differences between endoscopists in detection rate of adenomatous polyps (p = 0.001).
  • The range for the detection of at least 1 adenomatous polyp was 18,2-37,5% in that group.Also found that age and gender were powerful predictors of adenomatous polyps, both for the total cohort, and patients older than 50 years.
  • Regarding the indication for colonoscopy, no significant difference between the categories, were found p = 0.288 CONCLUSION S: The endoscopist is as or more important than age, gender or indication for the examination, in predicting the detection of adenomatous polyps during colonoscopy.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonoscopy / standards

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  • (PMID = 20066017.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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18. Park SY, Kim BC, Shin SJ, Lee SK, Kim TI, Kim WH: Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years. Hepatogastroenterology; 2009 May-Jun;56(91-92):677-81
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  • [Title] Proximal shift in the distribution of adenomatous polyps in Korea over the past ten years.
  • BACKGROUND/AIMS: Several reports have suggested a trend of right-side shift of colorectal cancer; however, there were only a few studies on the chronologic changes in the distribution of adenomatous polyps.
  • We aimed to study the changes in the distribution of colorectal adenomatous polyps over the past ten years.
  • Patients who had an adenomatous polyp with a diameter of at least 5mm were included.
  • Of these, patients with a history of colon resection, colorectal cancer, colorectal polyp, inflammatory bowel disease, HNPCC, or familial adenomatous polyposis were excluded.
  • RESULTS: A total of 2,498 patients and 4,591 adenomatous polyps were included in this study.
  • Analysis with respect to number of patients showed significant increases in the proportion of patients with adenomatous polyp on the proximal colon, from 48.5% to 66.3% (p<0.001).
  • Analysis with respect to number of polyps revealed that the proportion of adenomatous polyps on the proximal colon significantly increased from 48.9% to 62.3% (p<0.001).
  • CONCLUSIONS: The proportion of adenomatous polyp on the proximal colon significantly increased over the past 10 years.
  • [MeSH-major] Adenomatous Polyposis Coli / ethnology. Adenomatous Polyposis Coli / pathology. Asian Continental Ancestry Group / statistics & numerical data

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  • (PMID = 19621679.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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19. Kim BJ, Kim YH, Sinn DH, Kang KJ, Kim JY, Chang DK, Son HJ, Rhee PL, Kim JJ, Rhee JC: Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males. Cancer Causes Control; 2010 Jun;21(6):939-44

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  • [Title] Clinical usefulness of glycosylated hemoglobin as a predictor of adenomatous polyps in the colorectum of middle-aged males.
  • RESULTS: Subjects in their 50 s had significantly more adenomatous polyps than subjects in their 40 s (32.7% vs. 26.0%, p < 0.05).
  • The incidence of adenomatous polyp increased with increasing quartiles of HbA1C as follows: first quartile (19.9%, HbA1c 4.0-5.0), second quartile (27.8%, HbA1c 5.1-5.3), third quartile (32.7%, HbA1c 5.4-5.5), and fourth quartile (34.9%, HbA1c = 5.6-8.8)(p = 0.008).
  • When combining quartile of HbA1c and age (40 s vs. 50 s) according to HbA1C levels, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c <5.4% was significantly lower than that in subjects in their 50 s.
  • However, the odds ratio for adenomatous polyp in subjects in their 40 s with HbA1c > or =5.4% was similar to that in subjects in their 50 s with average risk for CRC.
  • CONCLUSIONS: An elevated HbA1c may be useful as a clinical predictor of adenomatous polyps in male subjects <50 years of age who have average risk for CRC.
  • [MeSH-major] Adenomatous Polyps / blood. Adenomatous Polyps / pathology

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  • (PMID = 20373014.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hemoglobin A, Glycosylated
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20. Gryfe R: Overview of colorectal cancer genetics. Surg Oncol Clin N Am; 2009 Oct;18(4):573-83
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  • Cancer is a genetic disease in which the clonal accumulation of genetic alterations confers a cell with the malignant characteristics of uncontrolled growth, local invasiveness, and metastastic potential.
  • Studies of colorectal cancer and its precursor lesion, the adenomatous polyp, have served as the cornerstone in advancing knowledge of cancer molecular genetics.

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  • (PMID = 19793566.001).
  • [ISSN] 1558-5042
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Number-of-references] 81
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21. Hizawa K, Yamamoto H, Yao T, Aomi H, Nakahara T, Matsumoto T, Iida M: [Gastric foveolar type adenomatous polyp arising in the duodenum]. Nihon Shokakibyo Gakkai Zasshi; 2005 Aug;102(8):1035-8
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  • [Title] [Gastric foveolar type adenomatous polyp arising in the duodenum].
  • [MeSH-major] Adenomatous Polyps / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 16124710.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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22. Leng Q, Wu KL, Jin HY, Liu P, Lin HP, Zhang JH, Ye H, Zhu Y, Zhang JC: [Distribution characteristics of colorectal neoplasm in 4450 patients and implication for colorectal cancer screening]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Nov;13(11):822-4
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  • RESULTS: Colorectal neoplasm was found in 24.8% (4450/17,939) of the patients during colonoscopy, including adenomatous polyp (n=3410, 19.0%) and adenocarcinoma (n=1040, 5.8%).
  • In patients with adenomatous polyp, 52.8% (1802/3410) of the lesions were at the distal colon, 30.8% (1049/3410) at the proximal colon, and 16.4% (559/3410) at both distal and proximal colon.

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  • (PMID = 21108058.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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23. Kim DH, Lee SY, Choi KS, Lee HJ, Park SC, Kim J, Han CJ, Kim YC: The usefulness of colonoscopy as a screening test for detecting colorectal polyps. Hepatogastroenterology; 2007 Dec;54(80):2240-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The usefulness of colonoscopy as a screening test for detecting colorectal polyps.
  • BACKGROUND/AIMS: Colonic polyps are the most common lesions encountered during screening colonoscopy.
  • The purpose of this study is to evaluate the usefulness of colonoscopy to detect colonic polyps in adults.
  • RESULTS: Complete colonic evaluation was possible in 4,491 (97.0%) subjects, and 804 (17.9%) had adenomatous polyps, including 153 subjects (3.4%) with advanced adenomas.
  • There was a trend toward an increased prevalence of adenomatous polyps with age.
  • Among the subjects with polyps, 72.1% of the subjects had distal polyps and the relative risk for proximal polyp, according to the distal findings, was 5.4 (95% CI: 4.5-6.3) for adenomatous polyp, 5.1 (95% CI 3.6-7.0) for advanced adenoma as compared to the finding of no adenomatous polyp.
  • CONCLUSIONS: Colonoscopy performed by experienced colonoscopists as a screening test is feasible for detecting subjects with colorectal polyps.
  • [MeSH-major] Colonoscopy. Intestinal Polyps / diagnosis. Rectal Diseases / diagnosis
  • [MeSH-minor] Adult. Age Distribution. Aged. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Female. Humans. Male. Mass Screening / methods. Middle Aged. Prevalence. Sex Distribution

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  • (PMID = 18265641.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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24. Mukhopadhyay S, Marhaba A, Sidhu JS: Small advanced neuroendocrine carcinoma of rectum discovered in an adenomatous polyp. Endoscopy; 2005 Dec;37(12):1256-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small advanced neuroendocrine carcinoma of rectum discovered in an adenomatous polyp.
  • [MeSH-major] Carcinoma, Neuroendocrine / secondary. Colonic Polyps / pathology. Liver Neoplasms / secondary. Rectal Neoplasms / pathology

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  • (PMID = 16329031.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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25. Patel VG, Darko ND, Martin DM, Lyons R, Marantz D: Serrated adenoma of the colon: an under-recognized premalignant variant of adenomatous polyp. Am Surg; 2010 Sep;76(9):E190-2
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  • [Title] Serrated adenoma of the colon: an under-recognized premalignant variant of adenomatous polyp.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Colectomy / methods. Colonic Polyps / epidemiology. Colonic Polyps / pathology. Colonic Polyps / surgery. Female. Humans. Immunohistochemistry. Incidence. Male. Middle Aged. Prognosis. Retrospective Studies. Risk Assessment. Sex Distribution. Survival Analysis. Treatment Outcome

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  • (PMID = 21396285.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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26. Kekilli M, Dagli U, Kalkan IH, Tunc B, Disibeyaz S, Ulker A, Sahin B: Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: a Turkish referral centre study. Scand J Gastroenterol; 2010 Apr;45(4):434-9
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  • OBJECTIVES: To determine the incidences of dysplasia, adenomatous polyp and colon cancer in patients with ulcerative colitis (UC) and to evaluate the risk factors.
  • In terms of localization, 80 patients (29.1%) had distal disease, 107 (38.9%) had left-sided disease and 88 (32.0%) had extensive colitis.
  • Adenomatous polyp was found in six patients (2.2%).
  • Five cases (83.3% of the polyps) were in the diseased segment and one case (16.7%) was in the non-diseased segment.
  • Adenomatous polyp was not found in cases with colon cancer.
  • The difference in rates may be explained by racial factors, specific environmental factors, intensive control of disease activity through medical therapy and effective colonoscopic surveillance programmes.
  • [MeSH-major] Colitis, Ulcerative / epidemiology. Colonic Polyps / epidemiology. Colorectal Neoplasms / epidemiology. Precancerous Conditions / epidemiology


27. Yang LP, Yang ZL, Tan XG, Miao XY: [Expression of annexin A1 (ANXA1) and A2 (ANXA2) and its significance in benign and malignant lesions of gallbladder]. Zhonghua Zhong Liu Za Zhi; 2010 Aug;32(8):595-9
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  • OBJECTIVE: To study the expression levels of ANXA1 and ANXA2 and elucidate their clinicopathological significance in adenocarcinoma, peritumoral tissues, adenomatous polyp and chronic cholecystitis of gallbladder.
  • METHODS: EnVision(TM) immunohistochemical staining was used to detect the expression of ANXA1 and ANXA2 in paraffin-embedded tissue sections from resected specimens of adenocarcinoma (n = 108), peritumoral tissue (n = 46), adenomatous polyp (n = 15) and chronic cholecystitis (n = 35).
  • RESULTS: The positive rates and scores of ANXA1 and ANXA2 were significantly higher in adenocarcinoma (59.3%, 56.5%; 3.2 ± 0.9, 3.4 ± 0.8) than those in peritumoral tissues (34.8%, 1.1 ± 0.8, P < 0.01; 30.4%, 1.0 ± 0.8, P < 0.01), adenomatous polyp (26.7%, 0.9 ± 0.7, P < 0.05 or P < 0.01; 26.7%, 0.9 ± 0.8, P < 0.05 or P < 0.01) and chronic cholecystitis (17.1%, 0.7 ± 0.9, P < 0.01; 20.0%, 0.8 ± 0.8, P < 0.01).
  • Kaplan-Meier analysis and multivariate Cox regression analysis showed that ANXA1 or ANXA2 was not an independent prognostic predictor in gallbladder adenocarcinoma.
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenomatous Polyps / metabolism. Adenomatous Polyps / pathology. Adult. Aged. Cholecystectomy / methods. Cholecystitis / metabolism. Cholecystitis / pathology. Female. Gallbladder / metabolism. Gallbladder / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Proportional Hazards Models. Survival Rate

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  • (PMID = 21122411.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ANXA2 protein, human; 0 / Annexin A1; 0 / Annexin A2
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28. Hwang NC, Kim YH, Shim SG, Son HJ, Rhee PL, Kim JJ, Paik SW, Rhee JC, Chun HK: [Is serum homocysteine level elevated in colorectal tumor?]. Korean J Gastroenterol; 2005 Feb;45(2):97-102
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  • The blood folate level does not reflect the systemic folate status.
  • One hundred fifty-one of 184 were included, excluding 33 patients with previous history of colonic polyp, cerebrovascular, cardiovascular attack and thromboembolism.
  • They were divided into the normal control (n=111) and the adenomatous polyp group (n=40).
  • However, in the subjects with high alcohol consumption, there was a significant difference in the mean serum homocysteine between the normal control (n=7) and the adenomatous polyp group (n=9) (10.2 vs 15.1 mumol/L, p<0.05).
  • However, in the subjects with high alcohol consumption, high serum homocysteine might be related to the development of adenomatous polyp.
  • [MeSH-major] Adenomatous Polyps / blood. Colorectal Neoplasms / blood. Homocysteine / blood

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  • (PMID = 15725713.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0LVT1QZ0BA / Homocysteine
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29. Ma YM, Wu BP, Xia OD: [Expression and significance of interferon-inducible transmembrane protein-1 gene in Peutz-Jeghers syndrome]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Mar;29(3):541-3
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  • OBJECTIVE: To detect the mRNA and protein expression of interferon-inducible transmembrane protein-1 (IFITM1) in Peutz-Jeghers syndrome (PJS) and investigate the role of IFITM1 in the occurrence, development and carcinogenesis of PJS polyps.
  • METHODS: Reverse transcription-PCR was employed to detect the mRNA expression of IFITM1 in 16 PJS polyp samples, adenomatous polyp tissues, colon adenocarcinoma samples, and normal intestinal mucosal tissues.
  • RESULTS: The IFITM1 mRNA expression was detected in all these tissues, and the expression intensity increased in the order of normal intestinal mucosa, PJS polyp, adenomatous polyp, and colon adenocarcinoma (F=92.704, P=0.000).
  • CONCLUSION: The expression level of IFITM1 is associated with the progression of the carcinogenetic process in PJS polyp, and can be used as a sensitive biomarker for diagnosis and prognostic evaluation of PJS.
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Differentiation. Biomarkers / metabolism. Disease Progression. Female. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Young Adult

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  • (PMID = 19304549.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Biomarkers; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / leu-13 antigen
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30. Hwang ST, Cho YK, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Won KH, Jin W: Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. J Gastroenterol Hepatol; 2010 Mar;25(3):562-7
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  • [Title] Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps.
  • Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver.
  • This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.
  • We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361).
  • RESULTS: The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group.
  • By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60).
  • An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps.
  • CONCLUSION: NAFLD was associated with colorectal adenomatous polyps.
  • Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.
  • [MeSH-major] Adenomatous Polyps / complications. Colorectal Neoplasms / complications. Fatty Liver / complications

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  • (PMID = 20074156.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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31. Liu DC, Yang ZL, Jiang S: Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma. Cancer Biomark; 2010-2011;8(3):113-21
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  • In this study, we investigated the expressions of Msi-1 and ALDH1 in gallbladder adenocarcinoma (n=100), peritumoral tissues (n=46), adenomatous polyp (n=15), and chronic cholecystitis (n=35) using immunohistochemical method.
  • The percentage of cases with positive Msi-1 and ALDH1 expression were significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues, adenomatous polyp and chronic cholecystitis (ps < 0.01).
  • [MeSH-minor] Adenomatous Polyps / metabolism. Adult. Aged. Cholecystitis / metabolism. Disease Progression. Female. Gallbladder / chemistry. Gallbladder / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Prognosis

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  • (PMID = 22012766.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / MSI1 protein, human; 0 / Nerve Tissue Proteins; 0 / RNA-Binding Proteins; EC 1.2.1.- / aldehyde dehydrogenase 1; EC 1.2.1.36 / Retinal Dehydrogenase
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32. Ji JH, Park BJ, Park YS, Hwang JH, Chung SH, Kim N, Lee DH, Jung HC, Song IS: [Clinicopathologic study of colorectal polyps and obesity in Korean adult]. Korean J Gastroenterol; 2007 Jan;49(1):10-6
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  • [Title] [Clinicopathologic study of colorectal polyps and obesity in Korean adult].
  • Numerous epidemiologic studies have shown a positive association between obesity and colorectal polyps.
  • There are few studies investigating the association between colorectal adenomatous polyps and body fat composition in Korea.
  • We tried to examine the relationship between body fatness and colorectal adenomatous polyps in health check-up subjects in Korea.
  • We tried to reveal the relationship between body mass index (BMI) and size, location, number and histopathological type of polyps.
  • RESULTS: The mean value of BMI in total polyp-free group (23.8+/-2.9) was not different from that of the polyp group (24.5+/-2.8, p=0.09).
  • The frequency of rectosigmoid polyps in obese patients (20.4%) was higher than that in non-obese patients (16.0%, p<0.05).
  • The frequency of adenomatous polyp was not different between obese and non-obese group.
  • Number of polyps (> or=4) correlated well with obesity.
  • Moreover, age and triglyceride level in patients with colonic adenoma were significantly higher than in patients without colonic adenom.
  • CONCLUSIONS: This study shows that obesity is not associated with colonic adenomatous polyp in Korean population.
  • However, we observed that obesity may be associated with rectosigmoid colon polyps.
  • Furthermore, age and triglyceride level might be the risk factors of colonic adenomatous polyps in Korean population.
  • [MeSH-major] Adenomatous Polyps / complications. Colonic Neoplasms / complications. Obesity / complications
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Body Mass Index. Colonic Polyps / complications. Colonic Polyps / epidemiology. Colonic Polyps / pathology. Comorbidity. Female. Humans. Korea. Male. Middle Aged. Retrospective Studies. Sigmoidoscopy

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  • (PMID = 18167428.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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33. Chakraborti AK, Garg SK, Kumar R, Motiwala HF, Jadhavar PS: Progress in COX-2 inhibitors: a journey so far. Curr Med Chem; 2010;17(15):1563-93
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  • Observation of increased cardiovascular risks in APPROVe (Adenomatous Polyp Prevention on Vioxx) study sent tremors and led to voluntary withdrawn of Vioxx (rofecoxib) by Merck from the market in September 2004 followed by Bextra (valdecoxib) in 2005 raising a question on the safety of selective COX-2 inhibitors.
  • Recognition of new avenues for selective COX-2 inhibitors such as cancer, Alzheimer's disease, Parkinson's disease, schizophrenia, major depression, ischemic brain injury and diabetic peripheral nephropathy has kindled the interest in these compounds.

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  • (PMID = 20166930.001).
  • [ISSN] 1875-533X
  • [Journal-full-title] Current medicinal chemistry
  • [ISO-abbreviation] Curr. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Heterocyclic Compounds; 0 / Lactones; 0 / Sulfones; 0 / lumiracoxib; 0QTW8Z7MCR / rofecoxib; 144O8QL0L1 / Diclofenac; EC 1.14.99.1 / Cyclooxygenase 2
  • [Number-of-references] 164
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34. Park KJ, Choi HJ, Kim SH, Han SY, Hong SH, Cho JH, Kim HH: Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction. World J Gastroenterol; 2006 Jan 7;12(1):146-9
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  • [Title] Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction.
  • We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp.
  • An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum.
  • CT scan showed the typical finding of intussusception.
  • The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.
  • [MeSH-major] Adenoma / complications. Intussusception / surgery. Laparoscopy / methods. Rectal Diseases / surgery. Sigmoid Neoplasms / complications

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  • [Cites] Surg Today. 2000;30(2):188-90 [10664347.001]
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  • (PMID = 16440436.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4077479
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35. Lee YH, Ji JD, Song GG: Adjusted indirect comparison of celecoxib versus rofecoxib on cardiovascular risk. Rheumatol Int; 2007 Mar;27(5):477-82
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  • We performed adjusted indirect comparison of celecoxib versus rofecoxib for cardiovascular events using two data on The Adenomatous Polyp Prevention on Vioxx (APPROVe) trial and Adenoma Prevention with Celecoxib (APC) trial.
  • The RRs for cardiovascular events derived from the adjusted indirect comparisons of the two coxibs did not significantly differ from unity (celecoxib versus rofecoxib; RR 0.95, 95% CI 0.76-1.19, p = 0.67).
  • [MeSH-minor] Adenoma / prevention & control. Adenomatous Polyps / prevention & control. Angina, Unstable / chemically induced. Celecoxib. Humans. Middle Aged. Risk. Thromboembolism / chemically induced

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  • (PMID = 17051359.001).
  • [ISSN] 0172-8172
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors; 0 / Lactones; 0 / Pyrazoles; 0 / Sulfonamides; 0 / Sulfones; 0QTW8Z7MCR / rofecoxib; JCX84Q7J1L / Celecoxib
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36. van den Broek I, Sparidans RW, Engwegen JY, Cats A, Depla AC, Schellens JH, Beijnen JH: Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer. Cancer Biomark; 2010;7(2):109-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Serum was obtained from patients with indications for colonoscopy, subsequently diagnosed as normal colon or hyperplastic polyp (CON; n= 368), adenomatous polyp (AP; n = 179) or colorectal cancer (CRC; n = 69).

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  • (PMID = 21178269.001).
  • [ISSN] 1875-8592
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / alpha-Defensins; 0 / human neutrophil peptide 1; 0 / human neutrophil peptide 2; 0 / human neutrophil peptide 3
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37. Marshall JR: Nutrition and colon cancer prevention. Curr Opin Clin Nutr Metab Care; 2009 Sep;12(5):539-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An exciting recent discovery is that the combination of diflouromethylornithine and sulindac substantially decreases adenomatous polyp recurrence.
  • Screening has an important role, although it will probably not eliminate all colon cancer.
  • Nutritional modification remains potentially valuable, although research has not yet identified the objects of nutritional intervention.

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  • (PMID = 19512917.001).
  • [ISSN] 1473-6519
  • [Journal-full-title] Current opinion in clinical nutrition and metabolic care
  • [ISO-abbreviation] Curr Opin Clin Nutr Metab Care
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 184SNS8VUH / Sulindac; R16CO5Y76E / Aspirin; ZQN1G5V6SR / Eflornithine
  • [Number-of-references] 41
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38. Greenwald B: From guaiac to immune fecal occult blood tests: the emergence of technology in colorectal cancer screening. Gastroenterol Nurs; 2005 Mar-Apr;28(2):90-6
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  • An accurate screening test would have high sensitivity (positive) when an adenomatous polyp or cancer is present and high specificity (negative) in their absence.


39. Qayyum A, Sawan AS: Profile of colonic biopsies in King Abdul Aziz University Hospital, Jeddah. J Pak Med Assoc; 2009 Sep;59(9):608-11
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  • Out of these, 181 patients showed nonspecific colitis, 122 showed ulcerative colitis and 15 cases were of Crohn's disease.
  • Of the 107 benign polyps seen, the most dominant was adenomatous polyp.
  • CONCLUSIONS: Among Inflammatory bowel diseases, ulcerative colitis is an important disease in our society.
  • Tubular adenomas are the most common type of polyps and adenocarcinoma is the most common malignancy of the colon.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adolescent. Adult. Aged. Child. Child, Preschool. Colitis, Ulcerative / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Female. Humans. Male. Middle Aged. Prevalence. Saudi Arabia / epidemiology. Young Adult

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  • (PMID = 19750855.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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40. Sánchez-Fayos Calabuig P, Martín Relloso MJ, Porres Cubero JC: [Genetic profile and molecular bases of pancreatic carcinogenesis]. Gastroenterol Hepatol; 2007 Dec;30(10):592-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The possibility that carcinogenesis is a multiphasic process has been well demonstrated in colorectal cancer, at least in cancers arising from a benign adenomatous polyp.

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  • (PMID = 18028855.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 51
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41. Cappell MS: Reducing the incidence and mortality of colon cancer: mass screening and colonoscopic polypectomy. Gastroenterol Clin North Am; 2008 Mar;37(1):129-60, vii-viii
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  • Most colon cancers arise from conventional adenomatous polyps (conventional adenoma-to-carcinoma sequence), while some colon cancers appear to arise from the recently recognized serrated adenomatous polyp (serrated adenoma-to-carcinoma theory).
  • A minimal colonoscopic withdrawal time of 6 minutes is important to maximize polyp detection at colonoscopy.
  • Chromoendoscopy is an experimental technique used to highlight abnormal colonic areas to identify neoplastic tissue and to potentially determine the histology of colonic polyps at colonoscopy based on superficial pit anatomy.

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  • (PMID = 18313544.001).
  • [ISSN] 0889-8553
  • [Journal-full-title] Gastroenterology clinics of North America
  • [ISO-abbreviation] Gastroenterol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 118
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42. Hasan N, Pollack A, Cho I: Infectious causes of colorectal cancer. Infect Dis Clin North Am; 2010 Dec;24(4):1019-39, x
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  • Our understanding of the pathogenesis of colorectal cancer, from the precursor adenomatous polyp to adenocarcinoma, has evolved rapidly.
  • [MeSH-major] Adenoma / etiology. Bacterial Infections / complications. Carcinoma / etiology. Colorectal Neoplasms / etiology. Virus Diseases / complications

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20937463.001).
  • [ISSN] 1557-9824
  • [Journal-full-title] Infectious disease clinics of North America
  • [ISO-abbreviation] Infect. Dis. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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43. Folker MB, Bernstein IT, Holck S: [Serrated, hyperplastic and hyperplasia-like colorectal polyps]. Ugeskr Laeger; 2006 Nov 13;168(46):4005-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Serrated, hyperplastic and hyperplasia-like colorectal polyps].
  • [Transliterated title] Serrate, hyperplastiske-og hyperplasilignende, kolorektale polypper.
  • The colorectal hyperplastic polyp has generally been considered a finding of no clinical significance.
  • Recent research has, however, called attention to the existence of some variants of hyperplastic polyp which are potentially malignant.
  • The term "advanced serrated polyp" has been coined for such cases, which comprise mixed hyperplastic/adenomatous tissue, serrated adenoma, and sessile serrated polyp, in contrast to the traditional hyperplastic polyp.
  • Since epithelial dysplasia is an integrated component of mixed hyperplastic/adenomatous polyp and of the serrated adenoma, such a diagnosis would dictate control colonoscopy comparable to the guidelines for subjects with conventional adenomas.
  • The cytology of the sessile serrated polyp is, however, closer to that of the traditional hyperplastic polyp, whereas the architecture mimics that of the serrated adenoma.
  • For this reason, a consensus regarding the optimal management of such patients has not been obtained, but if the polyp is sizeable and located in the right colon, control should be considered.
  • The small, usually left-sided traditional polyp as a rule needs no follow-up, but the context in which such a lesion is found and its morphology may influence the clinical decision.
  • Future large-scale investigations of serrated colorectal polyps, including interobserver studies, will be required to identify histological details of clinical utility which can be adopted in daily routine practice.
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17125655.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 40
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44. Lamberti C, Sauerbruch T: [Early diagnosis of colorectal tumors]. Internist (Berl); 2005 Apr;46(4):401-10
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  • Individuals older than 50 years or with a family history for colorectal tumors as well as patients with an inflammatory bowel disease have an increased risk for CRC.
  • A significant reduction of colorectal cancer mortality can be achieved by screening of asymptomatic patients and removal of premalignant adenomatous polyp precursors.
  • [MeSH-minor] Chronic Disease. Humans. Practice Guidelines as Topic. Practice Patterns, Physicians'. Prognosis. Risk Factors. Time Factors

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  • (PMID = 15723147.001).
  • [ISSN] 0020-9554
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 43
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45. Głuszko P, Bielińska A: Non-steroidal anti-inflammatory drugs and the risk of cardiovascular diseases: are we going to see the revival of cyclooxygenase-2 selective inhibitors? Pol Arch Med Wewn; 2009 Apr;119(4):231-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 2004 and 2005, predictions of some pharmacologists were confirmed when the Adenomatous Polyp Prevention on VIOXX trial (APPROVE) and other randomized, double-blind, placebo-controlled trials with COX-2 inhibitors showed an increased rate of thrombotic vascular events, including myocardial infarction, in patients treated with coxibs.

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  • (PMID = 19413182.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors
  • [Number-of-references] 23
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46. Nikpour S, Ali Asgari A: Colonoscopic evaluation of minimal rectal bleeding in average-risk patients for colorectal cancer. World J Gastroenterol; 2008 Nov 14;14(42):6536-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with the following alarm signs were excluded: Positive personal history of colorectal neoplasms or inflammatory bowel disease (IBD), positive first degree family history of colorectal neoplasms, history of altered bowel habits, recent significant weight loss, and presence of iron deficiency anemia.
  • Neoplastic polyps, colorectal carcinoma, and IBD were defined as significant lesions.
  • Significant lesions were found in 121 (30.1%) patients, including 26 patients (6.5%) with adenocarcinoma and 30 (7.5%) with adenomatous polyps.
  • Almost all patients with significant lesions had at least one lesion in the distal colon; an adenocarcinoma and an adenomatous polyp in the proximal colon were found in 2 patients with hemorrhoids.
  • Rigid sigmoidoscopy may be used as an alternative in patients less than 40 years of age in settings where the former is not available.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Hemorrhage / etiology


47. Akyürek N, Salman B, Irkörücü O, Sare M, Tatlicioğlu E: Ultrasonography in the diagnosis of true gallbladder polyps: the contradiction in the literature. HPB (Oxford); 2005;7(2):155-8

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  • [Title] Ultrasonography in the diagnosis of true gallbladder polyps: the contradiction in the literature.
  • Polypoid lesions of the gallbladder (PLGs) are often incidentally identified during ultrasonographic examination of abdominal pain.
  • Data were collected regarding the patients' gender, age, symptoms, serum lipid levels, the size and the number of polyps on US, surgical indications for PLGs and histopathological diagnosis.
  • Only 10 (18%) patients had adenomatous polyp and 8 of these polyps were larger than 1 cm.
  • Overall US-based diagnosis of gallbladder polyp was inaccurate in 82%.
  • The sensitivity and specificity of US for polyps <1 cm was 20% and 95.1%, respectively, whereas the sensitivity and specificity of US for polyps >1 cm was 80% and 99.3%, respectively.
  • The accuracy of US in diagnosing PLGs was poor, especially in polyps <1 cm.

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  • (PMID = 18333181.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2023942
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48. Farah-Klibi F, Kourda-Boujemaa J, Bouaskar I, Dziri C, Rachida Z, Jilani-Baltagi SB: Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature. Pathologica; 2009 Dec;101(6):255-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystadenocarcinoma of the appendix: an incidental perioperatory finding in a patient with adenocarcinoma of the ascending and sigmoid colon: case report and review of literature.
  • CASE PRESENTATION: A mucocele of the appendix, due to mucinous cystadenocarcinoma, was documented as an incidental perioperatory finding in a 68-year-old female.
  • Degenerated adenomatous polyp of the ascending colon and mucinous adenocarcinoma of the sigmoid colon invading the parietal peritoneum of the uterine and vagina was diagnosed.

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  • (PMID = 20387715.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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49. McKenzie S, Baek JH, Wakabayashi M, Garcia-Aguilar J, Pigazzi A: Totally laparoscopic right colectomy with transvaginal specimen extraction: the authors' initial institutional experience. Surg Endosc; 2010 Aug;24(8):2048-52

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  • A four-trocar laparoscopic right colectomy with intracorporeal anastomosis was performed for cancer in two cases and for adenomatous polyp in two cases.

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  • [CommentIn] Surg Endosc. 2011 May;25(5):1699-700 [20972582.001]
  • (PMID = 20108143.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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50. Levi Z, Rozen P, Hazazi R, Vilkin A, Waked A, Maoz E, Birkenfeld S, Niv Y: Can quantification of faecal occult blood predetermine the need for colonoscopy in patients at risk for non-syndromic familial colorectal cancer? Aliment Pharmacol Ther; 2006 Nov 15;24(10):1475-81
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • The quantitative immunochemical faecal occult blood test for human haemoglobin is specific and sensitive for significant colorectal neoplasia (cancer or advanced adenomatous polyp).
  • RESULTS: In 252 at-risk patients undergoing colonoscopy; five had cancer, 14 an advanced adenoma and 46 a non-advanced adenoma.

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  • (PMID = 17032281.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hemoglobins
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51. Levi Z, Vilkin A, Niv Y: Esophago-gastro-duodenoscopy is not indicated in patients with positive immunochemical test and nonexplanatory colonoscopy. Eur J Gastroenterol Hepatol; 2010 Dec;22(12):1431-4
MedlinePlus Health Information. consumer health - Gastrointestinal Bleeding.

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  • [Title] Esophago-gastro-duodenoscopy is not indicated in patients with positive immunochemical test and nonexplanatory colonoscopy.
  • In this study, we evaluated EGD findings in patients with positive immunochemical fecal occult blood test (I-FOBT) not explained by colonoscopy.
  • METHODS: Out of 1221 consecutive patients having total colonoscopy after preparing I-FOBT (OC-MICRO, with threshold of 75 or 100 ngHb/ml), we included only patients without colorectal cancer or advanced adenomatous polyp on colonoscopy, who also underwent EGD within 4 months of the fecal blood testing.
  • CONCLUSION: Immunological FOBT positivity was not correlated with the finding of lesions, which are likely to bleed on EGD.
  • Thus, EGD is probably not indicated in patients with positive I-FOBT and unrevealing colonoscopy.

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  • (PMID = 20962660.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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52. Wong DC, Wong SK, Leung AL, Chung CC, Li MK: Combined endolaparoscopic intragastric excision for gastric neoplasms. J Laparoendosc Adv Surg Tech A; 2009 Dec;19(6):765-70
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  • The remaining lesions were adenomatous polyp with focal intramucosal adenocarcinoma, leiomyoma, and pancreatic heterotopia.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Aged, 80 and over. Carcinoma / pathology. Carcinoma / surgery. Cohort Studies. Female. Humans. Leiomyoma / pathology. Leiomyoma / surgery. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 19645605.001).
  • [ISSN] 1557-9034
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Yee J, Rosen MP, Blake MA, Baker ME, Cash BD, Fidler JL, Grant TH, Greene FL, Jones B, Katz DS, Lalani T, Miller FH, Small WC, Sudakoff GS, Warshauer DM: ACR Appropriateness Criteria on colorectal cancer screening. J Am Coll Radiol; 2010 Sep;7(9):670-8
International Agency for Research on Cancer - Screening Group. diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers .

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  • This malignancy is ideally suited for screening because the detection and removal of the precursor adenomatous polyp can prevent most colorectal cancers from ever forming.
  • The double-contrast barium enema is an alternative imaging test that is appropriate particularly when CTC is not available.
  • Imaging tests including CTC and the double-contrast barium enema are usually not indicated for colorectal cancer screening in high-risk patients with polyposis syndromes or inflammatory bowel disease.
  • [MeSH-minor] Adenoma / complications. Biopsy. Colitis, Ulcerative / radiography. Colonography, Computed Tomographic / methods. Colonoscopy / statistics & numerical data. Crohn Disease / radiography. Humans. Risk Assessment. Survival Rate. Tomography, X-Ray Computed / methods. United States / epidemiology

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  • [Copyright] Copyright (c) 2010 American College of Radiology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20816627.001).
  • [ISSN] 1558-349X
  • [Journal-full-title] Journal of the American College of Radiology : JACR
  • [ISO-abbreviation] J Am Coll Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Tanaka T: Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog; 2009;8:5

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  • The large majority of colorectal malignancies develop from an adenomatous polyp (adenoma).
  • Carcinomas usually originate from pre-existing adenomas, but this does not imply that all polyps undergo malignant changes and does not exclude de novo oncogenesis.
  • Besides adenomas, there are other types of pre-neoplasia, which include hyperplastic polyps, serrated adenomas, flat adenomas and dysplasia that occurs in the inflamed colon in associated with inflammatory bowel disease.

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  • (PMID = 19332896.001).
  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2678864
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55. Kozu T, Iinuma G, Ohashi Y, Saito Y, Akasu T, Saito D, Alexander DB, Iigo M, Kakizoe T, Tsuda H: Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial. Cancer Prev Res (Phila); 2009 Nov;2(11):975-83
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial.
  • The aim of this study was to determine whether oral bLF could inhibit the growth of adenomatous colorectal polyps in human patients.
  • A randomized, double-blind, controlled trial was conducted in 104 participants, ages 40 to 75 years, with polyps <or=5 mm in diameter and likely to be adenomas.
  • Target adenomatous polyps were monitored by colonoscopy.
  • Ingestion of 3.0-g bLF significantly retarded adenomatous polyp growth in participants 63 years old or younger.
  • Removal of adenomatous colorectal polyps is done as a preventative measure against colorectal cancer; however, polyps can be overlooked, and when detected, polypectomy is not always 100% effective in eradicating a polyp.
  • Our study suggests that daily intake of 3.0 g of bLF could be a clinically beneficial adjunct to colorectal polyp extraction.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology. Lactoferrin / administration & dosage

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  • (PMID = 19861543.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Placebos; EC 3.4.21.- / Lactoferrin
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56. Half EE, Arber N: Chemoprevention of colorectal cancer: two steps forward, one step back? Future Oncol; 2006 Dec;2(6):697-704
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  • The poor survival rate has prompted the emphasis on prevention of this disease.
  • Sulindac and celecoxib were shown to be effective in promoting polyp regression in high-risk individuals with familial adenomatous polyposis.
  • In the more common sporadic setting, the Adenomatous Polyp PRevention On Vioxx (rofecoxib), Adenoma Prevention with Celecoxib and Prevention of Sporadic Adenomatous Polyps (celecoxib) trials have demonstrated a significant reduction in adenoma recurrence, but important concerns were raised regarding cardiovascular toxicity associated with selective cyclo-oxygenase-2 inhibitors.
  • Currently, the only approved agent for chemoprevention is celecoxib in high-risk individuals with familial adenomatous polyposis.
  • [MeSH-major] Adenoma / prevention & control. Adenomatous Polyps / drug therapy. Anticarcinogenic Agents / therapeutic use. Colonic Polyps / drug therapy. Colorectal Neoplasms / prevention & control

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  • (PMID = 17155896.001).
  • [ISSN] 1479-6694
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 0 / Cyclooxygenase 2 Inhibitors
  • [Number-of-references] 59
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57. Simsek BC, Pehlivan S, Karaoglu A: Human telomerase reverse transcriptase expression in colorectal tumors: correlations with immunohistochemical expression and clinicopathologic features. Ann Diagn Pathol; 2010 Dec;14(6):413-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • Human telomerase reverse transcriptase (hTERT) proteins in colorectal cancer investigated in several studies, but to our knowledge, hTERT expression has not been evaluated in all of colorectal tumors, including hyperplastic polyps (HPs), adenomas, and carcinomas, on paraffin-embedded tissue sections.
  • In this study, hTERT expression was determined in HP (n = 20), adenomatous polyp (AP) (n = 20), colorectal adenocarcinomas (n = 20), and normal mucosa (n = 20) by immunohistochemical method.
  • Thereby, hTERT expression may use the aggressiveness of the colorectal tumors as a marker, but it is not related to clinicopathologic data.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Adenomatous Polyps / metabolism. Colorectal Neoplasms / metabolism. Telomerase / metabolism

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21074689.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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58. Belshaw NJ, Elliott GO, Foxall RJ, Dainty JR, Pal N, Coupe A, Garg D, Bradburn DM, Mathers JC, Johnson IT: Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. Br J Cancer; 2008 Jul 8;99(1):136-42
The Lens. Cited by Patents in .

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  • Quantitative methylation-specific PCR profiling applied to biopsies was used to quantify low levels of CGI methylation of 18 genes in the morphologically normal colonic mucosa of neoplasia-free subjects, adenomatous polyp patients, cancer patients and their tumours.
  • Multinomial logistic regression models based on the CGI methylation profiles from normal mucosa correctly identified 78.9% of cancer patients and 87.9% of non-cancer (neoplasia-free+polyp) patients (P=4.93 x 10(-7)) using APC, HPP1, p16, SFRP4, WIF1 and ESR1 methylation as the most informative variables.
  • Similarly, CGI methylation of SFRP4, SFRP5 and WIF1 correctly identified 61.5% of polyp patients and 78.9% of neoplasia-free subjects (P=0.0167).

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  • (PMID = 18542073.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2453007
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59. Ozsunar Y, Coskun G, Delibaş N, Uz B, Yükselen V: Diagnostic accuracy and tolerability of contrast enhanced CT colonoscopy in symptomatic patients with increased risk for colorectal cancer. Eur J Radiol; 2009 Sep;71(3):513-8
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • Two masses and eight polyps, consisted of 1 tubulovillous, 1 tubular, 2 villous adenoma, 4 adenomatous polyp, 4 adenocarcinoma, were identified.

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  • (PMID = 18597964.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
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60. Harris JK, Froehlich F, Wietlisbach V, Burnand B, Gonvers JJ, Vader JP: Factors associated with the technical performance of colonoscopy: An EPAGE Study. Dig Liver Dis; 2007 Jul;39(7):678-89
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • AIMS: To determine factors associated with three performance indicators of colonoscopy: complete colonoscopy, adenomatous polyp diagnosis, and duration.
  • Patients from centres where over 50% of the endoscopists were of senior rank were roughly twice as likely to have an adenoma diagnosed, and longer average withdrawal duration (odds ratio: 1.08, 95% confidence interval: 1.07-1.09) was associated with more frequent adenoma diagnoses.
  • The non-modifiable factors permit the identification of patients who may be at greater risk of not having quality colonoscopy, while changes to the modifiable factors may help improve the quality of colonoscopy.
  • [MeSH-major] Adenomatous Polyps / diagnosis. Colonoscopes. Colonoscopy / standards. Colorectal Neoplasms / diagnosis. Quality Indicators, Health Care

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  • [CommentIn] Dig Liver Dis. 2007 Jul;39(7):690-1 [17531552.001]
  • (PMID = 17434349.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] Netherlands
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61. Ibrahim OO, Anjorin AS, Afolayan AE, Badmos KB: Pathological characterization of colorectal polyps in Ilorin, Nigeria. Afr J Med Med Sci; 2010 Sep;39(3):215-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathological characterization of colorectal polyps in Ilorin, Nigeria.
  • Colorectal polyps especially the adenomas are recognized precursors of colorectal carcinoma.
  • Identification and removal of such polyps before malignant transformation could reduce the burden of colorectal carcinoma.
  • To document the demography and the histopathological types ofcolorectal polyps received by the Department of Pathology of University of Ilorin Teaching Hospital over a period of thirty years.
  • This is a retrospective review of all cases ofcolorectal polyps that were received, processed and had histological diagnosis in our centre between 1979 and 2008 using the request cards and hematoxylin and eosin stained slides.
  • Forty-four cases of colorectal polyps were reviewed constituting 6.7 percent of all colorectal biopsies/resections received in the same period.
  • Seventeen (38.6%) were adenomas, 9 (20.5%) were juvenile polyps, 8 (18.2%) were inflammatory polyps, 4 cases were lipomatous polyps, 3 were leiomatous polyps, and one each of lymphoid polyp, hamartomatous polyp and neurofibromatous polyp.
  • Of the adenomas, 11 (58.8%) were tubular, 5 (29.4%) were villous, 1 (5.9%) was tubulovillous, and one was a villous adenoma with a focus of malignant transformation.
  • Adenomatous polyp is the commonest pathological type ofcolorectal polyps in our centre.
  • This study therefore sets out to review the age and sex distribution, location and morphological characteristics of all cases of colorectal polyps in our centre over the study period.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 21416791.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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62. Fujimura T, Ohta T, Oyama K, Miyashita T, Miwa K: Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers. J Gastrointest Cancer; 2007;38(2-4):78-82

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  • DISCUSSION: Since a randomized study for polyp chemoprevention by celecoxib in familial adenomatous polyposis (FAP) patients demonstrated a significant reduction in the number of colorectal polyps, the clinical use of celecoxib was approved for FAP patients.
  • Three large trials using celecoxib (the Adenoma Prevention with Celebrex and the Prevention of Spontaneous Adenomatopus Polyps) or refecoxib (the Adenomatous Polyp Prevention on Vioxx) for the recurrence of colorectal polyps in patients with a history of colorectal adenoma polypectomized confirmed chemopreventive effects on colorectal adenoma but two of three trails alerted us a hazard of cardiovascular (CV) events.

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  • (PMID = 19031117.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  • [Number-of-references] 36
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63. Lanza E, Hartman TJ, Albert PS, Shields R, Slattery M, Caan B, Paskett E, Iber F, Kikendall JW, Lance P, Daston C, Schatzkin A: High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial. J Nutr; 2006 Jul;136(7):1896-903
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  • [Title] High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial.
  • We examined the association between fruits and vegetables and adenomatous polyp recurrence in the Polyp Prevention Trial (PPT).
  • The PPT was a low-fat, high-fiber, high-fruit, and vegetable dietary intervention trial of adenoma recurrence, in which there were no differences in the rate of adenoma recurrence in participants in the intervention and control arms of the trial.
  • In this analysis of the entire PPT trial-based cohort, multiple logistic regression analysis was used to estimate the odds ratio (OR) of advanced and nonadvanced adenoma recurrence within quartiles of baseline and change (baseline minus the mean over 3 y) in fruit and vegetable intake, after adjustment for age, total energyy intake, use of nonsteroidal anti-inflammatory drugs, BMI, and gender.
  • There were no significant associations between nonadvanced adenoma recurrence and overall change in fruit and vegetable consumption; however, those in the highest quartile of change in dry bean intake (greatest increase) compared with those in the lowest had a significantly reduced OR for advanced adenoma recurrence (OR = 0.35; 95% CI, 0.18-0.69; P for trend = 0.001).
  • The PPT trial-based cohort provides evidence that dry beans may be inversely associated with advanced adenoma recurrence.

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  • (PMID = 16772456.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CN / Z01 CN000151-17; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS10712; NLM/ PMC1713264
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64. Bobe G, Sansbury LB, Albert PS, Cross AJ, Kahle L, Ashby J, Slattery ML, Caan B, Paskett E, Iber F, Kikendall JW, Lance P, Daston C, Marshall JR, Schatzkin A, Lanza E: Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial. Cancer Epidemiol Biomarkers Prev; 2008 Jun;17(6):1344-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial.
  • Department of Agriculture flavonoid database to examine the association between consumption of total flavonoids, 6 flavonoid subgroups, and 29 individual flavonoids with adenomatous polyp recurrence in the Polyp Prevention Trial.
  • The Polyp Prevention Trial was a randomized dietary intervention trial, which examined the effectiveness of a low-fat, high-fiber, high-fruit, and high-vegetable diet on adenoma recurrence.
  • Multivariate logistic regression models (adjusted for age, body mass index, sex, regular non-steroidal anti-inflammatory use, and dietary fiber intake) were used to estimate odds ratios and 95% confidence intervals for both any and advanced adenoma recurrence within quartiles of energy-adjusted flavonoid intake (baseline, during the trial, and change during the trial).
  • Total flavonoid intake was not associated with any or advanced adenoma recurrence.
  • However, high intake of flavonols, which are at greater concentrations in beans, onions, apples, and tea, was associated with decreased risk of advanced adenoma recurrence (4th versus 1st quartile during the trial; odds ratio, 0.24; 95% confidence interval, 0.11, 0.53; P(trend) = 0.0006).
  • Our data suggest that a flavonol-rich diet may decrease the risk of advanced adenoma recurrence.
  • [MeSH-major] Adenoma / prevention & control. Colorectal Neoplasms / prevention & control. Flavonoids / administration & dosage. Neoplasm Recurrence, Local / prevention & control

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  • (PMID = 18559549.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 BC010025-12
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flavonoids
  • [Other-IDs] NLM/ NIHMS56510; NLM/ PMC2517243
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65. Clements D, Tawfiq S, Harries B, Sheridan W: Application of the BSG guidelines to a colonoscopy waiting list. Colorectal Dis; 2009 Jun;11(5):513-5
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  • If applied less rigidly, 42% of patients should not have been on the list.
  • The reasons for removal from the list were as follows: Thirty-nine patients were older than the upper age limit, 23 had had clear colonoscopies after adenomatous polyp follow up, four were listed for diverticular disease follow up, four for metaplastic polyps, one for constipation and one for per rectum (PR) bleed follow up.
  • Conclusion With strict application of the BSG guidelines to a surveillance colonoscopy waiting list, 49% of the patients on the list do not need the procedure.

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  • (PMID = 18637926.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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66. Guebel DV, Torres NV: A computer model of oxygen dynamics in human colon mucosa: implications in normal physiology and early tumor development. J Theor Biol; 2008 Feb 7;250(3):389-409
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We concluded that cellular metabolism in normal colon mucosa is not limited by oxygen supply, thus prompting the idea that oxygenation does not determine the characteristic microenvironments occurring along the normal Lieberkhün crypts.
  • In an extended model, simulation of an aberrant crypt focus (ACF)--the earliest stage in the adenomatous polyp-carcinoma sequence--showed instead that respiratory activity decreased when the capillary array symmetry is disrupted due to the ACF growth.
  • [MeSH-minor] Cell Transformation, Neoplastic / metabolism. Computer Simulation. Disease Progression. Humans. Microcirculation. Oxygen / blood. Partial Pressure

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  • (PMID = 18022199.001).
  • [ISSN] 1095-8541
  • [Journal-full-title] Journal of theoretical biology
  • [ISO-abbreviation] J. Theor. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
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67. Augoff K, Rabczynski J, Tabola R, Czapla L, Ratajczak K, Grabowski K: Immunohistochemical study of decorin expression in polyps and carcinomas of the colon. Med Sci Monit; 2008 Oct;14(10):CR530-5
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical study of decorin expression in polyps and carcinomas of the colon.
  • It was hypothesized that physiological expression of decorin may be associated with cellular senescence of the colorectal mucosa and that its down-regulation, promoting an increase in cellular proliferation, could participate in the progression of adenoma to adenocarcinoma.
  • Therefore the expression of decorin in hyperplastic and neoplastic polyps of the colorectum was examined and compared with normal colonic mucosa and colon cancer tissues.
  • MATERIAL/METHODS: Tissue samples were obtained from 41 patients with different types of colonic polyps (6 hyperplastic adenomas, 34 neoplastic adenomas, and 1 adenomatous polyp with focal carcinoma) and 12 patients with colon cancer.
  • The decrease in decorin reactivity in tubulo-villous adenomas was significant as compared with other polyps and controls.
  • Weak decorin immunoreactivity in stroma adjacent to clusters of cancerous cells was also found in most cases of common types of adenocarcinoma, but not in adenocarcinoma mucinosum.
  • CONCLUSIONS: The expression of decorin may be involved in the differentiation of colonic polyps and reduced expression of decorin may abrogate the defensive potential of stromal tissue and promote the development of common types of colon carcinoma.
  • [MeSH-major] Colon / pathology. Colonic Polyps / metabolism. Colorectal Neoplasms / metabolism. Extracellular Matrix Proteins / metabolism. Proteoglycans / metabolism

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  • (PMID = 18830193.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans
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68. Fang P, Qian F, Wu JZ: [Clinicopathological analysis of 39 patients with multiple primary synchronous colorectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Nov;10(6):535-9
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The incidence of adenomatous polyp in synchronous CRC was higher than that in single CRC(59.0% vs 25.0%,P<0.01).
  • CONCLUSIONS: Synchronous CRC and single CRC are not always similar in clinicopathologic characteristics and prognosis.
  • Early finding, early diagnosis and radical operation are the keys to improve the survival rate of synchronous CRC.

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  • (PMID = 18000774.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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69. Beggs AD, Hodgson SV: The genomics of colorectal cancer: state of the art. Curr Genomics; 2008 Mar;9(1):1-10

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  • The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
  • Initial studies of the genetics of inherited colorectal cancer susceptibility concentrated on the inherited colorectal cancer syndromes, such as Familial Adenomatous Polyposis (FAP) and Lynch Syndrome (also known as HNPCC).
  • Recent research has concentrated on the pathways by which colorectal adenomatous polyps not due to one of these known inherited susceptibilities undergo malignant transformation, and determination of the types of polyps most likely to do so.
  • We will also discuss in detail the genetic changes in polyps that undergo malignant transformation as well as current knowledge with regards to the epigenomic changes found in colorectal polyps.

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  • (PMID = 19424478.001).
  • [ISSN] 1389-2029
  • [Journal-full-title] Current genomics
  • [ISO-abbreviation] Curr. Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2674304
  • [Keywords] NOTNLM ; Colorectal / cancer / epigenomics. / genomics
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70. Alder AC, Hamilton EC, Anthony T, Sarosi GA Jr: Cancer risk in endoscopically unresectable colon polyps. Am J Surg; 2006 Nov;192(5):644-8
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer risk in endoscopically unresectable colon polyps.
  • BACKGROUND: The purpose of the current study was to define the rate of underlying malignancy in endoscopically unresectable polyps.
  • METHODS: An institutional review board-approved review identified all patients undergoing colectomy for radiologically identified or endoscopically unresectable polyps between 1997 and 2006.
  • Patients were included if the endoscopic impression and biopsy findings suggested an adenomatous polyp without invasive cancer.
  • The median endoscopic size of polyps was 3.0 cm (range 0.8 to 10 cm).
  • Polyps were most frequently proximal to the splenic flexure (72%).
  • Size of polyp (P = .81) and histologic type (P = .34) were not significantly associated with invasive cancer.
  • Compared with polyps proximal to the splenic flexure, polyps located distally were more likely to harbor malignancy (rate; P < .02), by both univariate and multivariate analysis (odds ratio [OR] 1.38 [95% confidence interval 1.07 to 1.8]).
  • CONCLUSION: The cancer risk in polyps deemed inappropriate for endoscopic resection was lower than previously reported.
  • Neither polyp size nor histologic type appeared to be significantly associated with invasive cancer.
  • Location of an endoscopically unresectable polyp distal to the splenic flexure confers an increased risk for occult malignancy.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Polyps / pathology

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  • (PMID = 17071200.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Tam YH, Lee KH, Chan KW, Sihoe JD, Cheung ST, Mou JW: Colonoscopy in Hong Kong Chinese children. World J Gastroenterol; 2010 Mar 7;16(9):1119-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To investigate the safety and diagnostic yield of colonoscopy in Chinese children in whom the procedure is not often done.
  • Forty patients (50.6%) had a positive diagnosis made in colonoscopy and that included colonic polyps (23), Crohn's disease (12), ulcerative colitis (1), and miscellaneous causes (4).
  • 80% of polyps were in the rectosigmoid colon.
  • All but one were juvenile hamartomatous polyps.
  • The exception was an adenomatous polyp.
  • The mean ages for children with inflammatory bowel disease (IBD) and polyps were 11.3 and 4.3 years respectively.
  • The increasing diagnosis of IBD in recent decades may reflect a rising incidence of the disease in our children.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonoscopy. Inflammatory Bowel Diseases / diagnosis

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  • (PMID = 20205284.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2835790
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72. Arber N, Kuwada S, Leshno M, Sjodahl R, Hultcrantz R, Rex D, Exisulind Study Group: Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study. Gut; 2006 Mar;55(3):367-73
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  • [Title] Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study.
  • At baseline colonoscopy, left sided polyps (3-10 mm) were tattooed, measured, and left in place.
  • Follow up sigmoidoscopy was performed after six months, and removal of any remaining polyps at the 12 month colonoscopy.
  • The primary efficacy variable was change in polyp size from baseline.
  • The decrease in median polyp size was significantly greater (p=0.03) in patients who received exisulind 400 mg (-10 mm2) compared with those who received placebo (-4 mm2).
  • Complete or partial response was significantly higher in the exisulind 400 mg group (54.6%) compared with the placebo group (30.2%), and disease progression was significantly lower (6.1% v 27.9%) (p=0.04 and 0.02, respectively).
  • CONCLUSION: Exisulind caused significant regression of sporadic adenomatous polyps but was associated with more toxicity.
  • This model of polyp regression, short in its term and involving a comparatively small patient sample size, may be the best available tool to assess a therapeutic regimen before launching into large preventive clinical studies.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Antineoplastic Agents / therapeutic use. Sulindac / analogs & derivatives
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Colonoscopy. Combined Modality Therapy. Disease Progression. Dose-Response Relationship, Drug. Double-Blind Method. Female. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16150858.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 184SNS8VUH / Sulindac; K619IIG2R9 / sulindac sulfone
  • [Other-IDs] NLM/ PMC1856089
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73. Summers RM, Liu J, Yao J, Brown L, Choi JR, Pickhardt PJ: Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps. AJR Am J Roentgenol; 2009 Nov;193(5):1305-10
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  • [Title] Automated measurement of colorectal polyp height at CT colonography: hyperplastic polyps are flatter than adenomatous polyps.
  • OBJECTIVE: Hyperplastic polyps are more difficult to detect than adenomatous polyps at CT colonography (CTC), and it has been theorized that this difference in detectability is because hyperplastic polyps are flatter.
  • Using automated software that computes polyp height, we determined whether hyperplastic colonic polyps on CTC are indeed flatter than adenomatous polyps of comparable width.
  • One hundred eighty-five of the patients had at least one hyperplastic or adenomatous polyp 6-10 mm visible at both OC and CTC, where size was determined by a calibrated guidewire at OC.
  • To assess flatness, the heights of the polyps at CTC were measured using a validated automated software program.
  • The heights and height-to-width ratios of the hyperplastic polyps were compared with those of the adenomatous polyps using a Student's t test (two-tailed, unpaired, unequal variance).
  • RESULTS: There were 176 adenomatous and 83 hyperplastic polyps visible at segment-unblinded OC.
  • The fraction of these polyps that were measurable at CTC using the automated software was not significantly different for adenomatous versus hyperplastic polyps (158/176 [89.8%] vs 73/87 [83.9%], respectively; p = 0.2).
  • The average height-to-width ratios using automated width measurements were 15% less for hyperplastic polyps: 0.39 +/- 0.20 (n = 158) and 0.33 +/- 0.19 (n = 73) for adenomatous and hyperplastic polyps, respectively (p = 0.03).
  • When polyps of comparable OC size or CTC width were considered, the heights of hyperplastic polyps were up to 27% less than those of adenomatous polyps.
  • CONCLUSION: For 6-10 mm polyps of a given size as determined by OC or a given width at CTC, hyperplastic polyps tend to be flatter (i.e., have lower height) compared with adenomatous polyps.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic. Radiographic Image Interpretation, Computer-Assisted / methods
  • [MeSH-minor] Adenomatous Polyps / pathology. Adenomatous Polyps / radiography. Aged. Analysis of Variance. Automation. Colonoscopy. Contrast Media. Female. Humans. Hyperplasia. Male. Middle Aged. Retrospective Studies. Software

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  • (PMID = 19843746.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-05; United States / Intramural NIH HHS / / Z01 CL040003-06; United States / Intramural NIH HHS / / ZIA CL040003-07; United States / Intramural NIH HHS / / ZIA CL040003-08; United States / Intramural NIH HHS / / ZIA CL040003-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ NIHMS394801; NLM/ PMC3412299
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74. Shin A, Shrubsole MJ, Ness RM, Wu H, Sinha R, Smalley WE, Shyr Y, Zheng W: Meat and meat-mutagen intake, doneness preference and the risk of colorectal polyps: the Tennessee Colorectal Polyp Study. Int J Cancer; 2007 Jul 1;121(1):136-42
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  • [Title] Meat and meat-mutagen intake, doneness preference and the risk of colorectal polyps: the Tennessee Colorectal Polyp Study.
  • Although meat intake has been fairly consistently linked to the risk of colorectal cancer, only a few studies have evaluated meat intake by doneness level and the heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) produced by high temperature cooking of meat in relation to colorectal adenomatous and hyperplastic polyps.
  • Included in this study were participants with adenomatous polyp only (n = 573), hyperplastic polyp only (n = 256), or both adenomatous and hyperplastic polyps (n = 199), and 1,544 polyp-free controls.
  • Polytomous logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals for the association between exposures and colorectal polyp risks.
  • Presence of hyperplastic polyp was found to be positively associated with high consumption of total meat (p(trend) = 0.076) or red meat (p(trend) = 0.060), with an approximate 50-60% elevated risk observed in the highest vs. the lowest intake group.
  • High intake of 2-amino-I-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,4,8-trimethylimidazo [4,5]quinoxaline (DiMeIQx) were associated with increased risk for hyperplastic polyp (p(trend) = 0.036 and 0.038, respectively).
  • This study provides additional support for a positive association of high intake of red meat with colorectal adenomas, and suggests that high intake of meats and meat carcinogens may also be associated with hyperplastic polyps.

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  • (PMID = 17354224.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / P50 CA950103; United States / NCI NIH HHS / CA / R01 CA97386
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mutagens
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75. Zhou PH, Yao LQ, Chen WF: [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum]. Zhonghua Wai Ke Za Zhi; 2008 Sep 15;46(18):1386-9
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  • [Title] [Endoscopic therapy of adenomatous polyps and early-stage carcinomas of the colon and rectum].
  • OBJECTIVE: To assess the clinical efficacy of endoscopic treatment for colorectal adenomatous polyps and early-stage carcinomas.
  • METHODS: Between January 2006 and October 2007, 245 patients with colorectal adenomatous polyps and early-stage carcinomas with lifting sign(+) were treated by such endoscopic techniques as polypectomy, endoscopic mucosal resection (EMR), endoscopic piecemeal mucosal resection (EPMR) and endoscopic submucosal dissection (ESD).
  • CONCLUSIONS: Endoscopic resection appears to be an efficacious procedure to treat adenomatous polyp and early-stage carcinoma and provide pathological information about the whole lesion.
  • [MeSH-major] Adenomatous Polyps / surgery. Colorectal Neoplasms / surgery. Endoscopes, Gastrointestinal

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  • (PMID = 19094508.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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76. Rehani B, Chasen RM, Dowdy Y, Bharija A, Satter M, Strohmeyer P, Mantil J: Advanced adenoma diagnosis with FDG PET in a visibly normal mucosa: a case report. J Med Case Rep; 2007;1:99

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  • [Title] Advanced adenoma diagnosis with FDG PET in a visibly normal mucosa: a case report.
  • BACKGROUND: An accurate, early diagnosis and treatment of adenomatous polyp can curtail progression to colorectal cancer.
  • Motivated by the PET scan finding, the colonoscopist performed a biopsy which revealed a villous adenoma without high grade dysplasia.
  • Pathology from tissue extracted during an exploratory laparatomy completed one month later found the lesion to be a villous adenoma with high grade dysplasia.
  • CONCLUSION: Whole-body FDG PET scan revealed the biochemical metabolic changes in malignancy that preceded the appearance of any gross anatomical abnormality.

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  • (PMID = 17883865.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2040155
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77. Lee SS, Park SH, Choi EK, Kim SY, Kim MJ, Lee KH, Kim YH: Colorectal polyps on portal phase contrast-enhanced CT colonography: lesion attenuation and distinction from tagged feces. AJR Am J Roentgenol; 2007 Jul;189(1):35-40
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  • [Title] Colorectal polyps on portal phase contrast-enhanced CT colonography: lesion attenuation and distinction from tagged feces.
  • OBJECTIVE: The purpose of our study was to determine the attenuation of colorectal polyps on portal phase contrast-enhanced CT colonography (CTC) and evaluate whether enhanced polyps can be clearly distinguished from tagged feces during CTC review.
  • Forty-eight colonoscopy-proven polyps (6-20 mm) and 41 polypoid tagged feces (6-19 mm) were selected from contrast-enhanced CTC performed without (n = 37 examinations) and with (n = 10 examinations) fecal tagging, respectively.
  • Attenuation of the polyps and tagged feces was measured.
  • Four independent blinded radiologists reviewed the polyps and tagged feces at both wide (width, 1,500 H; level -400 H) and soft-tissue (width, 400 H; level, 20 H) window settings to distinguish them by using subjective visual assessment.
  • RESULTS: Polyp attenuation on the portal phase was not correlated with size (R = -0.003; p = 0.99) and was not different between histologic types (p = 0.884).
  • Enhanced polyps (mean +/- SD, 119.9 +/- 25.3 H; range, 50-173 H) showed significantly lower attenuation than did tagged feces (1,521.4 +/- 683.6 H; range, 495-2,683 H) without any overlap (p < 0.0005).
  • An 8-mm sessile adenomatous polyp was misinterpreted as tagged feces by one reviewer.
  • CONCLUSION: Polyp attenuation on portal phase contrast-enhanced CTC ranges from 50 to 173 H.
  • Contrast-enhanced polyps are clearly and consistently distinguished from barium-tagged polypoid feces.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic / methods. Contrast Media / administration & dosage. Feces. Radiographic Image Enhancement / methods. Rectal Diseases / radiography

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  • (PMID = 17579149.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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78. Levi Z, Rozen P, Hazazi R, Vilkin A, Waked A, Maoz E, Birkenfeld S, Lieberman N, Klang S, Niv Y: Sensitivity, but not specificity, of a quantitative immunochemical fecal occult blood test for neoplasia is slightly increased by the use of low-dose aspirin, NSAIDs, and anticoagulants. Am J Gastroenterol; 2009 Apr;104(4):933-8
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  • [Title] Sensitivity, but not specificity, of a quantitative immunochemical fecal occult blood test for neoplasia is slightly increased by the use of low-dose aspirin, NSAIDs, and anticoagulants.
  • RESULTS: Colorectal cancer (CRC) was found in 17 and advanced adenomatous polyp (AAP) in 97 patients.
  • The specificity, however, was not affected by the use of aspirin/NSAIDS.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / adverse effects. Anticoagulants / adverse effects. Aspirin / adverse effects. Colonic Polyps / diagnosis. Colorectal Neoplasms / diagnosis. Gastrointestinal Hemorrhage / diagnosis. Occult Blood

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  • [CommentIn] Am J Gastroenterol. 2009 Apr;104(4):939-41 [19293790.001]
  • (PMID = 19293792.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticoagulants; R16CO5Y76E / Aspirin
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79. Kline CL, Jackson R, Engelman R, Pledger WJ, Yeatman TJ, Irby RB: Src kinase induces tumor formation in the c-SRC C57BL/6 mouse. Int J Cancer; 2008 Jun 15;122(12):2665-73
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  • However, although Src protein is increased in colon cancer as early as the adenomatous polyp stage, a role for Src in carcinogenesis has not been established.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18351644.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 9038-94-2 / Metallothionein; EC 2.7.10.2 / src-Family Kinases
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80. Erdem L, Akbayir N, Yildirim S, Köksal HM, Yenice N, Gültekin OS, Sakiz D, Peker O: Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon. Turk J Gastroenterol; 2005 Dec;16(4):207-11
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • [Title] Predictive value of morphologic characteristics in rectosigmoid adenomatous polyps for the probability of synchronous polyps or cancer in the proximal colon.
  • The necessity of colonoscopy in patients with an adenoma of<or=5 mm found on sigmoidoscopy is controversial.
  • METHODS: Patients found to have rectosigmoid adenomatous polyps on colonoscopy were included in the study.
  • These adenomas were grouped as diminutive (<or=5 mm), small (6-10 mm) or large (>or=11 mm) polyps.
  • These groups were compared regarding the presence of proximal adenoma and advanced proximal neoplasia (>10 mm adenoma and/or villous histology and/or high grade dysplasia or cancer).
  • Polyps found in the rectum and sigmoid colon were considered as distal polyps and polyps other than these were considered as proximal polyps.
  • RESULTS: In this study, of 1124 consecutive patients who underwent colonoscopy between April 1997 and January 2002, 184 (16%) had 258 adenomatous polyps in the rectosigmoid area.
  • The polyps were diminutive (<or=5 mm) in 105, small (6-10 mm) in 46 and large (>or=11 mm) in 33 patients.
  • Forty-one of the patients (39%) with diminutive polyps, 20 of the patients (43%) with small polyps and 19 of the patients (57%) with large polyps had neoplasm in the proximal bowel.
  • The rate of advanced proximal neoplasm was found to be significantly higher in the group with large polyps in the rectosigmoid area than in the groups with small and diminutive polyps (p<0.05).
  • In 104 patients (57%) with polyp(s) in rectum and sigmoid colon, no associated polyp or cancer was encountered in the proximal colon.
  • CONCLUSION: Colonoscopy is indicated when adenomatous polyp, regardless of size, is found on rectosigmoidoscopy performed because of symptoms.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Neoplasms, Multiple Primary. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology

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  • (PMID = 16547849.001).
  • [ISSN] 1300-4948
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Turkey
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81. Fireman Z, Zachlka R, Abu Mouch S, Kopelman Y: The role of endoscopy in the evaluation of iron deficiency anemia in premenopausal women. Isr Med Assoc J; 2006 Feb;8(2):88-90
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  • METHODS: Upper and lower gastrointestinal endoscopic examinations were conducted in 45 premenopausal women with iron deficiency anemia not related to gynecologic or nutritional causes.
  • Twenty-eight upper gastrointestinal lesions were demonstrated in 24 of the 43 patients (55.8%): erosive gastritis in 12 (27.9%), erosive duodenitis in 4 (9.3%), erosive esophagitis in 3 (7.0%), hiatus hernia (with Cameron lesions) in 3 (7.0%), active duodenal ulcer in 1 (2.3%) and hyperplastic polyp (10 mm) in 1 (2.3%).
  • Five lower gastrointestinal lesions were detected in 5 patients (16.3%): 2 (4.6%) had adenocarcinoma of the right colon, 2 (4.6%) had pedunculate adenomatous polyp > 10 mm, and 1 (2.3%) had segmental colitis (Crohn's disease).
  • [MeSH-minor] Adolescent. Adult. Age Factors. Chronic Disease. Female. Humans. Middle Aged

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  • (PMID = 16544728.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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82. Hao CY, Moore DH, Wong P, Bennington JL, Lee NM, Chen LC: Alteration of gene expression in macroscopically normal colonic mucosa from individuals with a family history of sporadic colon cancer. Clin Cancer Res; 2005 Feb 15;11(4):1400-7
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  • To determine whether these alterations also occur in the MNCM of individuals who have not developed colon cancer but are at high risk of doing so, we measured gene expression in the MNCM of individuals with a family history of colon cancer.
  • CONCLUSIONS: Molecular abnormalities that precede the appearance of adenomatous polyp are present in the MNCM of individuals who have a family history of colon cancer.
  • To assess this possibility, prospective studies will be needed to determine whether or not altered gene expression is associated with the subsequent development of adenomatous polyps and/ or colonic carcinomas.

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  • (PMID = 15746039.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-8; 0 / Membrane Proteins; 0 / PPAR delta; 0 / PPAR gamma; 0 / Serum Amyloid A Protein; 63231-63-0 / RNA; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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83. Half E, Arber N: Colon cancer: preventive agents and the present status of chemoprevention. Expert Opin Pharmacother; 2009 Feb;10(2):211-9
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  • CRC has a natural history of transition from a precursor lesion, ie adenomatous polyp to cancer, that spans over 10 to 15 years providing an extended opportunity for intervention and cancer prevention.
  • All articles and other referenced materials were retrieved using the keywords "colon cancer", "adenoma", "chemoprevention", "non steroidal anti-inflammatory drugs", "aspirin", "HMG-CoA reductase inhibitors", "bile acids", "Difluoromethylornithine", "hormone replacement therapy", "mesalamine", "curcumin", and "calcium".
  • Currently, only celecoxib is FDA approved for chemoprevention of CRC and only for high-risk patients with Familial Adenomatous Polyposis (FAP).
  • CONCLUSION: Many agents have shown positive results in the field of chemoprevention however, the ideal chemopreventive agent remains to be discovered with great emphasis on need not to harm.
  • [MeSH-major] Adenomatous Polyps / prevention & control. Anticarcinogenic Agents. Colorectal Neoplasms / prevention & control

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  • (PMID = 19236194.001).
  • [ISSN] 1744-7666
  • [Journal-full-title] Expert opinion on pharmacotherapy
  • [ISO-abbreviation] Expert Opin Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 0 / Bile Acids and Salts; 0 / Cyclooxygenase 2 Inhibitors; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • [Number-of-references] 87
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84. Yuan B, Jin X, Zhu R, Zhang X, Liu J, Wan H, Lu H, Shen Y, Wang F: Cronkhite-Canada syndrome associated with rib fractures: a case report. BMC Gastroenterol; 2010;10:121
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  • Up till now, many complications of CCS have been reported in the literature, but rib fracture is not included.
  • Esophagogastroduodenoscopy, video capsule endoscopy and colonoscopy revealed various sizes of generalized gastrointestinal polyps.
  • Histological examination of the biopsy specimens obtained from the stomach and the colon showed adenomatous polyp and inflammatory polyp respectively.
  • Examinations, including emission computed tomography, bone densitometry test, and other serum parameters, were performed, but could not identify the definite etiology of the rib fractures.

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  • [Cites] Gastrointest Endosc. 2001 Sep;54(3):388-91 [11522989.001]
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  • (PMID = 20955587.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2972238
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85. Gill S, Sinicrope FA: Colorectal cancer prevention: is an ounce of prevention worth a pound of cure? Semin Oncol; 2005 Feb;32(1):24-34
Hazardous Substances Data Bank. SELENIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colorectal carcinogenesis is a multistep process characterized by molecular and cellular alterations that result in an identifiable precursor lesion, ie, the adenomatous polyp.
  • The transition from normal mucosa to adenoma and its subsequent progression to carcinoma are protracted events that offer opportunities for preventive interventions.
  • Interest in this field derives from multiple epidemiologic studies showing that regular and continued use of nonsteroidal anti-inflammatory drugs (NSAIDs), predominantly aspirin, is associated with significant reductions in both colorectal adenoma and carcinoma incidence.
  • NSAIDs were first shown to be effective in patients with familial adenomatous polyposis (FAP).
  • Based on the aforementioned data, aspirin and coxibs have been or are currently being evaluated for the prevention of sporadic adenoma recurrence in high-risk patient populations.
  • Evidence indicates that aspirin can reduce adenoma recurrence rates in patients with prior colorectal neoplasia; however, questions remain, including the optimal dosage, timing of initiation and duration of treatment, and clinical benefit versus potential harm to patients.
  • Apart from aspirin, calcium carbonate is the only other agent that has been shown to modestly reduce sporadic adenoma recurrence rates in a randomized trial.
  • [MeSH-minor] Adenoma / pathology. Animals. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Aspirin / therapeutic use. Calcium / therapeutic use. Clinical Trials as Topic. Cyclooxygenase Inhibitors / therapeutic use. Eflornithine / therapeutic use. Folic Acid / therapeutic use. Humans. Intestinal Mucosa / pathology. Selenium / therapeutic use. Ursodeoxycholic Acid / therapeutic use

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  • (PMID = 15726503.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; 0 / Cyclooxygenase Inhibitors; 724L30Y2QR / Ursodeoxycholic Acid; 935E97BOY8 / Folic Acid; H6241UJ22B / Selenium; R16CO5Y76E / Aspirin; SY7Q814VUP / Calcium; ZQN1G5V6SR / Eflornithine
  • [Number-of-references] 122
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86. Baron JA, Sandler RS, Bresalier RS, Lanas A, Morton DG, Riddell R, Iverson ER, Demets DL: Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet; 2008 Nov 15;372(9651):1756-64
SciCrunch. DrugBank: Data: Chemical .

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  • The Adenomatous Polyp Prevention on Vioxx (APPROVe) study assessed the effect of 3-year treatment with a cyclo-oxygenase-2 inhibitor, rofecoxib (25 mg), on recurrence of neoplastic polyps of the large bowel.
  • The APTC hazard ratio did not substantially change over time.

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  • [CommentIn] Lancet. 2008 Nov 15;372(9651):1712-3 [18922571.001]
  • [CommentIn] Evid Based Med. 2009 Aug;14(4):111 [19648427.001]
  • [ErratumIn] Lancet. 2008 Nov 15;372(9651):1732
  • (PMID = 18922570.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00282386
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Lactones; 0 / Sulfones; 0QTW8Z7MCR / rofecoxib
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87. Simmen FA, Frank JA, Wu X, Xiao R, Hennings LJ, Prior RL: Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol; 2009 Sep 16;9:67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BB increased (P < 0.05) ACF numbers within the distal colon of female but not male rats.
  • There was a tendency (0.1 > P > 0.05) for fewer adenocarcinomas (relative to total of adenomatous polyps plus adenocarcinomas) in colons of female than male tumor-bearing rats; in small intestine, this gender difference was significant (P < 0.05).
  • BB favored (P < 0.05) fewer adenocarcinomas and more adenomatous polyps (as a proportion of total tumor number) in female rat small intestine.
  • CONCLUSION: Results did not indicate robust cancer-preventive effects of BB.
  • Data indicate the potential for slowing tumor progression (adenomatous polyp to adenocarcinoma) by BB.

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  • (PMID = 19758446.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CB / N02-CB-07008
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / C-Peptide; MO0N1J0SEN / Azoxymethane
  • [Other-IDs] NLM/ PMC2752457
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88. Moug SJ, Vernall N, Saldanha J, McGregor JR, Balsitis M, Diament RH: Endoscopists' estimation of size should not determine surveillance of colonic polyps. Colorectal Dis; 2010 Jul;12(7):646-50
MedlinePlus Health Information. consumer health - Colonoscopy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopists' estimation of size should not determine surveillance of colonic polyps.
  • OBJECTIVE: Current British Society of Gastroenterology guidelines use adenomatous polyp size as one of the key factors in determining polyp follow-up.
  • This study aimed to compare polyp size assessment by colonoscopists and pathologists before and after fixation to determine the optimal method for measurement.
  • METHOD: Thirty-five colorectal polyps were found during pre-arranged colonoscopies in one centre.
  • Polyp size was measured to the nearest 1 mm by three different methods: 1. by the endoscopist at colonoscopy; 2. by the pathologist fresh, following removal; 3. by the pathologist fixed, following fixation.
  • RESULTS: Seventeen men, eighteen women with mean age of 66.2 years (SD: 9.4, range: 38.7-85.5) underwent polypectomy/s with all polyps removed intact.
  • The median size (mm) of polyps measured were endoscopically, 6.5 (2-25 mm); fresh specimen 7.0 (4-28 mm) and fixed 7.0 (4-28 mm).
  • In three patients, the endoscopic measurement was < 1 cm in polyps that were found to be >or= 1 cm on pathological measurement.
  • CONCLUSIONS: Endoscopists consistently underestimated polyp size.
  • Fixation had no effect on polyp size.
  • Pathologists' measurement of polyp size on fixed specimens should determine the need for further colonoscopic follow-up.
  • [MeSH-major] Colonic Polyps / pathology. Colonoscopy / statistics & numerical data. Mass Screening

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  • (PMID = 19486095.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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89. Kon OL, Yip TT, Ho MF, Chan WH, Wong WK, Tan SY, Ng WH, Kam SY, Eng AKh, Ho P, Viner R, Ong HS, Kumarasinghe MP: The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile. BMC Med Genomics; 2008;1:54
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  • BACKGROUND: Overall gastric cancer survival remains poor mainly because there are no reliable methods for identifying highly curable early stage disease.
  • Nine non-cancer samples that clustered with cancer samples included 5 pre-malignant lesions (1 adenomatous polyp and 4 intestinal metaplasia).

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  • (PMID = 18950519.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2584050
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90. Yantiss RK, Oh KY, Chen YT, Redston M, Odze RD: Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases. Am J Surg Pathol; 2007 Aug;31(8):1238-45
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • In this study, we describe a previously uncharacterized type of adenomatous polyp of the colorectum that shows prominent, thin, elongated projections of neoplastic epithelium with a serrated contour, which we have termed "filiform serrated adenoma" (SA).
  • Routinely processed polypectomy specimens from 18 patients with filiform SA and 23 controls with traditional (nonfiliform) SA were evaluated for their clinical and pathologic features, and immunohistochemically stained for a variety of markers (O-methylguanine methyltransferase, MLH1, MSH2, CDX2, nuclear beta-catenin, p53, and Ki-67) designed to evaluate their molecular and proliferative characteristics.
  • Four (22%) filiform SAs also contained nonserrated adenomatous elements with a villous (3 cases) or tubular (1 case) growth pattern.
  • None of the polyps in the control group showed stromal edema, high-grade dysplasia, or mixed elements.
  • Polyps in both groups demonstrated comparable staining patterns for O-methylguanine methyltransferase, MLH-1, MSH-2, CDX2, beta-catenin, and Ki-67, and none showed increased nuclear p53 expression.
  • Four cases showed silent p53 mutations upon direct sequencing and 4 revealed loss of heterozygosity at the loci evaluated, including 1 at D5S346 [adenomatous polyposis coli (APC) gene], 1 at D17S250 (p53 gene), and 2 at MYCL (chromosome 1p34).
  • We conclude that filiform SA potentially represents an unusual variant of SA with a predilection for the left colon, particularly the rectum.
  • [MeSH-major] Adenomatous Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17667549.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Genetic Markers; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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91. Hartman TJ, Albert PS, Snyder K, Slattery ML, Caan B, Paskett E, Iber F, Kikendall JW, Marshall J, Shike M, Weissfeld J, Brewer B, Schatzkin A, Lanza E, Polyp Prevention Study Group: The association of calcium and vitamin D with risk of colorectal adenomas. J Nutr; 2005 Feb;135(2):252-9
Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .

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  • The Polyp Prevention Trial (PPT) was a multicenter randomized clinical trial designed to determine the effects of a high-fiber, high-fruit and vegetable, low-fat diet on the recurrence of adenomatous polyps in the large bowel.
  • Adenoma recurrence was ascertained by complete colonoscopy at baseline and after 1 and 4 y.
  • We evaluated the association between calcium and vitamin D intake and adenomatous polyp recurrence after adjusting for intervention group, age, gender, nonsteroidal anti-inflammatory drug use, total energy intake, and the interaction of gender and intervention group.
  • There were no overall significant associations between adenoma recurrence and dietary calcium intake [odds ratio (OR) for the 5th compared with the lowest quintile = 0.91; 95% CI = 0.67-1.23; P-trend = 0.68], total calcium intake (OR = 0.86; 95% CI = 0.62-1.18; P-trend = 0.20), or dietary vitamin D intake (OR = 0.93; 95% CI = 0.69-1.25; P-trend = 0.43) averaged over follow-up.
  • Total vitamin D intake was weakly inversely associated with adenoma recurrence (OR = 0.84; 95% CI = 0.62-1.13; P-trend = 0.03).
  • Supplemental calcium and vitamin D use during follow-up also were inversely associated with adenoma recurrence (OR for any compared with no use = 0.82; 95% CI = 0.68-0.99; and OR = 0.82; 95% CI = 0.68-0.99; for calcium and vitamin D, respectively).
  • Our analyses did not suggest a significant effect modification between total calcium and total vitamin D intake (P = 0.14) on risk for adenoma recurrence.
  • This trial cohort provides some evidence that calcium and vitamin D may be inversely associated with adenoma recurrence.
  • [MeSH-major] Adenoma / epidemiology. Calcium. Colonic Neoplasms / epidemiology. Diet. Rectal Neoplasms / epidemiology. Vitamin D
  • [MeSH-minor] Body Mass Index. Colonic Polyps / prevention & control. Diet Records. Dietary Supplements. Educational Status. Female. Humans. Male. Middle Aged. Recurrence. Risk Factors. United States / epidemiology

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  • (PMID = 15671222.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 1406-16-2 / Vitamin D; SY7Q814VUP / Calcium
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92. Hayes SJ: Assessment of colorectal adenomatous polyp size measured during pathological examination highlights the importance of accuracy. Gastrointest Endosc; 2009 Sep;70(3):540-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of colorectal adenomatous polyp size measured during pathological examination highlights the importance of accuracy.
  • [MeSH-major] Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 19555943.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] United States
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93. Militsa NN, Postolenko ND, Kotelevets VV, Lazareva NV: [Successful operative treatment of multiple intestinal invagination, caused by adenomatous polyp of colon transversum]. Klin Khir; 2008 Jun;(6):57-8
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  • [Title] [Successful operative treatment of multiple intestinal invagination, caused by adenomatous polyp of colon transversum].

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  • (PMID = 18982730.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] RUS
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ukraine
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94. Kil Lee S, Il Kim T, Kwan Shin S, Ho Kim W, Kim H, Kyu Kim N: Comparison of the clinicopathologic features between flat and polypoid adenoma. Scand J Gastroenterol; 2008;43(9):1116-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of the clinicopathologic features between flat and polypoid adenoma.
  • OBJECTIVE: Several reports have suggested that flat colorectal adenomas might exhibit a higher potential for malignancy compared to polypoid adenomas.
  • Although the clinical importance of the shape of polyps is stressed, the controversy surrounding the malignant potential of flat adenomas continues.
  • The aim of this study was to compare the clinicopathologic characteristics, including degree of dysplasia and malignancy, between flat and polypoid adenomas 5 mm in size or larger.
  • MATERIAL AND METHODS: A total of 3263 polyps (254 flat adenomas and 3009 polypoid adenomas), >/=5 mm in size, diagnosed in 1883 patients by colonoscopy were analyzed.
  • The flat adenomas were larger in diameter than the polypoid adenomas (14.8+/-12.6 mm versus 8.6+/-5.0 mm, p <0.01), had a higher rate of villous components (18.5% versus 11.4%, p <0.01), a higher rate of high-grade dysplasia (9.4% versus 4.2%, p <0.01), and a higher rate of malignancy (10.2% versus 3.6%, p <0.01) than polypoid adenomas.
  • However, there was no difference in the rate of high-grade dysplasia or carcinoma between flat and polypoid adenomas of equal size.
  • It was shown by multivariate analysis that rectosigmoid location, larger size, and presence of a villous component were associated with a higher rate of malignancy, but not with flat morphology.
  • CONCLUSIONS: Flat adenomas, which were of a relatively large size in this study, were not associated with a higher risk for high-grade dysplasia and carcinoma compared with polypoid adenomas.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 18609172.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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95. Powers HJ, Hill MH, Welfare M, Spiers A, Bal W, Russell J, Duckworth Y, Gibney E, Williams EA, Mathers JC: Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study). Cancer Epidemiol Biomarkers Prev; 2007 Oct;16(10):2128-35
Hazardous Substances Data Bank. Riboflavin .

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  • [Title] Responses of biomarkers of folate and riboflavin status to folate and riboflavin supplementation in healthy and colorectal polyp patients (the FAB2 Study).
  • A double-blind randomized placebo-controlled intervention study (the FAB2 Study) was carried out in healthy controls and patients with colorectal polyps (adenomatous and hyperplastic) to examine effects of folic acid and riboflavin supplements on biomarkers of nutrient status and on putative biomarkers of colorectal cancer risk (DNA methylation and DNA damage; to be reported elsewhere).
  • Ninety-eight healthy controls and 106 patients with colorectal polyps were stratified for the thermolabile variant of methylene tetrahydrofolate reductase, MTHFR C677T, and were randomized to receive 400 microg of folic acid, 1,200 microg of folic acid, or 400 microg of folic acid plus 5 mg of riboflavin or placebo for 6 to 8 weeks.
  • Riboflavin supplement enhanced the response to low-dose folate in people carrying at least one T allele and having polyps.
  • The magnitude of the response in mucosal folate was positively related to the increase in plasma 5-methyl tetrahydrofolate but was not different between the healthy group and polyp patients.
  • [MeSH-major] Adenomatous Polyposis Coli / drug therapy. Biomarkers, Tumor / blood. Folic Acid / administration & dosage. Folic Acid / blood. Riboflavin / administration & dosage. Riboflavin / blood

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  • (PMID = 17932361.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tetrahydrofolates; 0LVT1QZ0BA / Homocysteine; 134-35-0 / 5-methyltetrahydrofolate; 935E97BOY8 / Folic Acid; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); TLM2976OFR / Riboflavin
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96. Giardiello FM, Hylind LM, Trimbath JD, Hamilton SR, Romans KE, Cruz-Correa M, Corretti MC, Offerhaus GJ, Yang VW: Oral contraceptives and polyp regression in familial adenomatous polyposis. Gastroenterology; 2005 Apr;128(4):1077-80
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  • [Title] Oral contraceptives and polyp regression in familial adenomatous polyposis.
  • We describe a patient in the placebo arm of a 4-year primary chemoprevention trial who developed adenomatous polyps and then had eradication of polyps after the administration of oral contraceptives.
  • No change in the prostaglandin levels in the colonic mucosa was noted after polyp elimination, making nonsteroidal anti-inflammatory drug ingestion unlikely as a cause.
  • [MeSH-major] Adenomatous Polyposis Coli / physiopathology. Contraceptives, Oral / therapeutic use

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  • (PMID = 15825088.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 51085; United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / CA 63721; United States / NCI NIH HHS / CA / P50 CA 9316
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral; 0 / Prostaglandins
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97. Rastogi A, Pondugula K, Bansal A, Wani S, Keighley J, Sugar J, Callahan P, Sharma P: Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology. Gastrointest Endosc; 2009 Mar;69(3 Pt 2):716-22
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  • [Title] Recognition of surface mucosal and vascular patterns of colon polyps by using narrow-band imaging: interobserver and intraobserver agreement and prediction of polyp histology.
  • BACKGROUND: The 2 main types of colon polyps are adenomas and hyperplastic.
  • Pit patterns on the surface of polyps have been described by using magnification chromoendoscopy, which can help differentiate between polyp types.
  • Narrow band imaging (NBI) is a novel technology that enhances the visualization of surface mucosal and vascular patterns on the polyp surface.
  • Earlier we described, in a pilot study, patterns seen on the polyp surface with NBI that can help differentiate between adenomas and hyperplastic polyps with a high degree of accuracy.
  • OBJECTIVE: The aim of this study was to evaluate the interobserver and intraobserver agreement (among endoscopists) for the NBI surface mucosal and vascular patterns and prediction of polyp histology and the accuracy of the investigators to predict polyp histology based on these patterns.
  • METHODS: NBI images of the polyp surface mucosal and vascular patterns obtained in our pilot trial were retrieved.
  • A teaching set of 20 images was selected to educate and demonstrate the polyp patterns to 4 endoscopists.
  • Subsequently, the test set of images was evaluated by the 4 endoscopists for quality, polyp pattern, and prediction of polyp type.
  • Interobserver agreement (k value) was calculated among the 4 assessors for the polyp patterns and predicted histology.
  • By using the final histology as the criterion standard, the accuracy of polyp-type prediction was calculated for each assessor.
  • After a period of 2 months, all polyp images were reevaluated by the assessors (as before), and all findings were recorded in a similar fashion.
  • These results were used for calculation of intraobserver agreement (k value) and the accuracy of the assessors in predicting polyp type.
  • RESULTS: Photographs of 65 polyps were included in the test set and were evaluated by the 4 assessors.
  • Thirty-eight polyps were adenomatous, and 27 were hyperplastic.
  • The kappa value for the interobserver agreement for polyp surface pattern was 0.57 (moderate) and for prediction of polyp type was 0.63 (substantial).
  • The kappa value for the intraobserver agreement of the 4 assessors for the surface patterns was 0.70, 0.65, 0.60, and 0.79, and for the prediction of polyp type was 0.87, 0.71, 0.61, 0.81.
  • The accuracy to predict polyp type ranged from 80% to 86% for the 4 assessors in the first reading and from 85% to 91% in the second reading, with every assessor showing an improvement in accuracy in the second reading.
  • LIMITATIONS: A single-center study, with a limited number of polyps.
  • CONCLUSIONS: This initial evaluation showed that the NBI polyp patterns described in our pilot study are reproducible, easy to learn, reasonably accurate, and have the potential for use in daily clinical practice for the real-time differentiation of colon polyps.
  • [MeSH-major] Colonic Polyps / pathology. Colonoscopy / statistics & numerical data

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  • [CommentIn] Gastrointest Endosc. 2009 Mar;69(3 Pt 2):723-5 [19251017.001]
  • (PMID = 19251016.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Ramirez M, Schierling S, Papaconstantinou HT, Thomas JS: Management of the malignant polyp. Clin Colon Rectal Surg; 2008 Nov;21(4):286-90

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  • [Title] Management of the malignant polyp.
  • In the United States, the prevalence of adenomatous polyps found during colonoscopic evaluation ranges from 25 to 41%, and of these, 2 to 5% contain invasive malignancy.
  • The management of the malignant polyp continues to be challenging.
  • Endoscopic resection by polypectomy has been shown to be sufficient for management of certain polyps containing cancer; however, it is important to keep in mind that polypectomy does not remove the lymph node drainage basin and may be an inadequate resection for some adenocarcinoma containing polyps that have specific histologic features.

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  • (PMID = 20011440.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780260
  • [Keywords] NOTNLM ; Haggitt level / Malignant polyp / adenocarcinoma / adenomatous polyp / endoscopic polypectomy / segmental colectomy
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99. Zasada J, Rembiasz K, Budzyński A, Gwóźdź A, Matłok M, Budzyński P, Dyduch G: [Endoscopic piecemeal removal of large adenomatous duodenal polyp]. Przegl Lek; 2009;66(5):263-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endoscopic piecemeal removal of large adenomatous duodenal polyp].
  • Duodenal polyps are rare pathologies.
  • They can be single or multiple, like in familial adenomatous polyposis or Gardner syndrome.
  • Small polyps localized in the superior or descending segment of duodenum can be usually removed endoscopically.
  • Larger or more distally localized polyps must be excised surgically.
  • The largest polyps, up to several centimeters, are adenomas.
  • Here we report the case of a 52 year old woman with a large polyp (7 cm diameter) localized in the duodenal bulb presenting with anemia.
  • The polyp was removed endoscopically with a piecemeal method using diathermic loop.
  • [MeSH-major] Adenoma / surgery. Duodenal Neoplasms / surgery. Duodenoscopy / methods
  • [MeSH-minor] Female. Humans. Intestinal Polyps / pathology. Intestinal Polyps / surgery. Middle Aged

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  • (PMID = 19739585.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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100. Parfitt JR, Shepherd NA: Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp! Histopathology; 2008 Jul;53(1):91-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp!
  • AIMS: Polypoid mucosal prolapse near the anorectal junction mimics adenomas endoscopically and histopathologically.
  • The aim was to describe the phenomenon of polypoid mucosal prolapse arising secondary to adenomas at the anorectal junction.
  • METHODS AND RESULTS: Four cases of low rectal adenoma with polypoid mucosal prolapse were assessed histopathologically, as well as with p53 and Ki67 antibodies.
  • CONCLUSIONS: Histopathologists must recognize the potential for adenomatous/dysplastic foci in anorectal lesions to superficially resemble inflammatory cloacogenic polyps.
  • We believe that polypoid mucosal prolapse changes can be a secondary phenomenon, due to adenomas close to or at the anorectal junction.
  • [MeSH-major] Adenoma / pathology. Intestinal Mucosa / pathology. Intestinal Polyps / diagnosis. Rectal Neoplasms / pathology. Rectal Prolapse / pathology. Rectum / pathology

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  • (PMID = 18484980.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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