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1. Kim H, Kim HJ, Chi SG, Lee SK, Joo GR, Dong SH, Kim BH, Chang YW, Lee JI, Chang R: Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea. World J Gastroenterol; 2006 Feb 14;12(6):951-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea.
  • AIM: Recently, germ-line mutation in the base excision repair gene MYH has been identified to cause a novel autosomal recessive form of familial adenomatous polyposis (FAP).
  • In this study, we screened 30 patients with multiple adenomatous polyps for MYH mutations to assess its prevalence and ethnic specificity in Korea.
  • METHODS: Thirty patients (21 men and 9 women; mean age 62.3 years) with multiple adenomatous polyps were examined for MYH mutations.
  • CONCLUSION: Mutation in MYH may be rarely involved in the pathogenesis of multiple sporadic colorectal adenomas in Korean population, although a large-scale analysis will be required to clarify the presence of specific MYH variants in a subset of patients and their role in the predisposition of multiple colorectal adenomas in Korean population.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Mutation

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  • (PMID = 16521226.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC4066163
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2. Chimenos-Küstner E, Pascual M, Blanco I, Finestres F: Hereditary familial polyposis and Gardner's syndrome: contribution of the odonto-stomatology examination in its diagnosis and a case description. Med Oral Patol Oral Cir Bucal; 2005 Nov-Dec;10(5):402-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hereditary familial polyposis and Gardner's syndrome: contribution of the odonto-stomatology examination in its diagnosis and a case description.
  • Familial Adenomatous Polyposis (FAP) and its phenotype variant, Gardner's syndrome, constitute a rare autosomal dominant inherited disorder.
  • They are characterised by the development, generally during the second and third decades of life, of multiple adenomatous polyps in the colon and rectum.
  • These polyps have a high risk of subsequently becoming malignant, which normally occurs in the third and fourth decades of life.
  • As well as colorectal polyps, these individuals can present with extra-colonic symptoms, among which are particularly: gastro-duodenal polyps, dermoid and epidermoid cysts, desmoid tumours, congenital hypertrophy of the retinal pigment epithelium, disorders of the maxillary and skeletal bones and dental anomalies.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Jaw Neoplasms / etiology. Osteoma / etiology
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / genetics. Adult. Cementoma / diagnosis. Cementoma / etiology. Codon, Nonsense. Diagnosis, Differential. Early Diagnosis. Epidermal Cyst / diagnosis. Epidermal Cyst / etiology. Female. Fibroma / diagnosis. Fibroma / etiology. Gardner Syndrome / complications. Gardner Syndrome / diagnosis. Gardner Syndrome / genetics. Genes, APC. Humans. Hypertrophy. Pedigree. Pigment Epithelium of Eye / abnormalities. Prognosis

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  • (PMID = 16264375.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Codon, Nonsense
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3. El Idrissi F, Fadli A: [Erosive adenomatosis of the nipple]. J Gynecol Obstet Biol Reprod (Paris); 2005 Dec;34(8):813-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Erosive adenomatosis of the nipple].
  • The histological analysis led to the diagnosis of erosive nipple adenomatosis.
  • Erosive adenomatosis of the nipple is a benign tumor which developing within the lactic nipple.
  • Erosive adenomatosis of the nipple is very rare and should be suspected in patients with nipple erosions or a nipple tumor.

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  • (PMID = 16319774.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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4. Laumonier H, Rullier A, Saric J, Balabaud C, Bioulac-Sage P: Unexpected discovery of 2 cases of hepatocyte nuclear factor 1alpha-mutated infracentimetic adenomatosis. World J Gastroenterol; 2008 Aug 14;14(30):4830-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unexpected discovery of 2 cases of hepatocyte nuclear factor 1alpha-mutated infracentimetic adenomatosis.
  • We present 2 cases of hepatocyte nuclear factor 1alpha (HNF1alpha)-mutated adenomatosis, discovered for reasons unrelated to this disease, and identified using immunohistochemical methods.
  • These new tools may further our understanding of the link between adenomas/adenomatosis subtypes and their complications, and their association with other abnormalities.

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  • (PMID = 18720549.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095817
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hepatocyte Nuclear Factor 1-alpha
  • [Other-IDs] NLM/ PMC2739350
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5. Fearnhead NS, Winney B, Bodmer WF: Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model. Cell Cycle; 2005 Apr;4(4):521-5
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes.
  • [MeSH-minor] Adenomatous Polyps / pathology. Base Pair Mismatch. DNA Repair. Disease Susceptibility. Genetic Variation. Humans. Intestinal Polyps. Multifactorial Inheritance. Risk. Wnt Proteins / metabolism

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  • (PMID = 15753653.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins
  • [Number-of-references] 62
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6. Barthelmes L, Tait IS: Liver cell adenoma and liver cell adenomatosis. HPB (Oxford); 2005;7(3):186-96

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver cell adenoma and liver cell adenomatosis.
  • During the last three decades liver cell adenoma and liver cell adenomatosis have emerged as new clinical entities in hepato-logical practice due to the widespread use of oral contraceptives and increased imaging of the liver.
  • In liver cell adenomatosis, the association with oral contraceptive use is not as high as in solitary liver cell adenomas.
  • Liver transplantation is the last resort in case of substantive concern about malignant transformation or for large, painful adenomas in liver cell adenomatosis after treatment attempts by liver resection.

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  • [CommentIn] HPB (Oxford). 2006;8(1):71-2 [18333245.001]
  • (PMID = 18333188.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2023950
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7. Steinhagen E, Markowitz AJ, Guillem JG: How to manage a patient with multiple adenomatous polyps. Surg Oncol Clin N Am; 2010 Oct;19(4):711-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How to manage a patient with multiple adenomatous polyps.
  • Adenomatous polyps are found on screening colonoscopy in 22.5% to 58.2% of the adult population and therefore represent a common problem.
  • Patients with multiple adenomatous polyps are of unique interest because a proportion of these patients have an inheritable form of colorectal cancer.
  • [MeSH-major] Adenomatous Polyposis Coli / therapy. Colorectal Neoplasms, Hereditary Nonpolyposis / therapy
  • [MeSH-minor] Adenomatous Polyps / genetics. Adenomatous Polyps / pathology. Adenomatous Polyps / therapy. Genetic Predisposition to Disease. Humans

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20883948.001).
  • [ISSN] 1558-5042
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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8. Hagiwara S, Takagi H, Kanda D, Sohara N, Kakizaki S, Katakai K, Yoshinaga T, Higuchi T, Nomoto K, Kuwano H, Mori M: Hepatic adenomatosis associated with hormone replacement therapy and hemosiderosis: a case report. World J Gastroenterol; 2006 Jan 28;12(4):652-5
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatic adenomatosis associated with hormone replacement therapy and hemosiderosis: a case report.
  • We have reported a case of hepatic adenomatosis associated with hormone replacement therapy (estrogen and progesterone) and hemosiderosis caused by excessive blood transfusion for the treatment of chronic myeloid leukemia.
  • Histopathological examination of the surgical specimen showed hepatic adenomatosis with hemosiderosis.
  • Both hormone replacement therapy and iron overload could be the cause of hepatic adenomatosis.

  • Genetic Alliance. consumer health - Hemosiderosis.
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  • (PMID = 16489686.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4066105
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9. Parés D, García-Ruiz A, Biondo S, Blanco I, Llort G, Arriol E, de Oca J, del Río C, Osorio A, Navarro M, Martí-Ragué J, Jaurrieta E: [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis]. Gastroenterol Hepatol; 2006 Jan;29(1):15-20
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  • [Title] [Current status of follow-up of the upper digestive tract in familial adenomatous polyposis].
  • [Transliterated title] Estado actual del seguimiento del área gastroduodenal en la poliposis adenomatosa familiar.
  • Familiar adenomatous polyposis (FAP) is a hereditary disease characterized by the development of multiple adenomatous polyps in the gastrointestinal tract and colorectal cancer in practically all patients who do not receive appropriate treatment.
  • Because of the possibility of malignant transformation of these polyps, adequate monitoring is required, even though the optimal follow-up schedule has not yet been defined.
  • Subsequently, a follow-up schedule should be designed, according to the number and histological characteristics of the polyps observed.
  • [MeSH-major] Adenocarcinoma / etiology. Adenomatous Polyposis Coli / complications. Stomach Neoplasms / etiology

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  • (PMID = 16393625.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 34
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10. Lipton L, Tomlinson I: The genetics of FAP and FAP-like syndromes. Fam Cancer; 2006;5(3):221-6

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  • The presence of multiple adenomatous polyps in the large bowel confers a high lifetime risk of colorectal cancer.
  • Although many cases of classical familial adenomatous polyposis (> 100 polyps) can be accounted for by mutations in the adenomatous polyposis coli (APC) gene, a large group of patients remains with multiple (5-100) adenomas and in whom there is no detectable APC mutation.
  • Recently two new genetic variants have been found to be associated with multiple colorectal adenomas and cancer, MYH/MUTYH on chromosome 1p and the HMPS/CRAC1 locus on chromosome 15q13-q14.
  • New information also continues to emerge regarding the less common hamartomatous polyposis conditions, Peutz-Jeghers syndrome and Juvenile Polyposis syndrome.
  • In this review we draw together some of the most recent information pertinent to the molecular pathogenesis of colorectal polyposis.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Genes, APC / physiology. Neoplastic Syndromes, Hereditary / genetics

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  • (PMID = 16998667.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 36
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11. van Esch AA, Drenth JP, te Morsche RH, Jansen JB, Nagengast FM: Recurrent idiopathic pancreatitis in familial adenomatous polyposis: report of a case-series and review of the literature. Fam Cancer; 2007;6(3):275-80
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  • [Title] Recurrent idiopathic pancreatitis in familial adenomatous polyposis: report of a case-series and review of the literature.
  • Familial adenomatous polyposis (FAP) is characterized by the development of multiple adenomatous polyps predominantly in the colon but also in the duodenum.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Duodenal Neoplasms / complications. Pancreatitis, Chronic / complications. Polyps / complications


12. McCart A, Latchford A, Volikos E, Rowan A, Tomlinson I, Silver A: A novel exon duplication event leading to a truncating germ-line mutation of the APC gene in a familial adenomatous polyposis family. Fam Cancer; 2006;5(2):205-8
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  • [Title] A novel exon duplication event leading to a truncating germ-line mutation of the APC gene in a familial adenomatous polyposis family.
  • Familial Adenomatous Polyposis (FAP) is an autosomal dominant condition predisposing to multiple adenomatous polyps of the colon.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Exons. Gene Duplication. Genes, APC. Germ-Line Mutation

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  • (PMID = 16736293.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / APC2 protein, human; 0 / Cytoskeletal Proteins
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13. Barreda Costa C, Vila Gutierrez S, Salazar Cabrera F, Barriga Calle E, Velarde Criado H, Barriga Briceño J: [Advanced adenoma in 3700 colonoscopies]. Rev Gastroenterol Peru; 2010 Apr-Jun;30(2):113-20
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  • OBJECTIVES: To determine the prevalence of colon polyps, distribution in the colon, as well as their histological characteristics, with special mention on advanced adenomas, in an adult population at an endoscopy center in Lima.
  • Each polyp was studied separately and its histological findings recorded.
  • RESULTS: 3,701 colonoscopies were done in 3,690 patients; 1,492 (40,4%) had polyps and were included in the study.
  • 997 (27%) had adenomatous polyps and 495 (13.4%) non adenomatous polyps.
  • Adenomatous polyps were found throughout the colon, with a predominance of hyperplasic polyps in the rectum.
  • 78% of the adenomatous polyps and 84% of the advanced adenomas were found in patients older than 50 years old.
  • In this group of patients, significant risk factors were: prior history of adenomas or colorectal cancer (46/203 vs. 63/495; p<0.01), and multiple adenomatous polyps found during colonoscopy (67/203 vs. 121/794; p<0.01).
  • CONCLUSIONS: Adenomatous polyps were the most frequently found polyps in our study; approximately 20% were advanced lesions, especially in patients older than 50 years old.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Colonoscopy / statistics & numerical data. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adenomatous Polyps / diagnosis. Adenomatous Polyps / epidemiology. Adenomatous Polyps / pathology. Adult. Age Factors. Aged. Aged, 80 and over. Early Diagnosis. Humans. Hyperplasia. Middle Aged. Motivation. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / pathology. Organ Specificity. Peru / epidemiology. Prospective Studies. Young Adult

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  • (PMID = 20644602.001).
  • [ISSN] 1609-722X
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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14. Durno CA, Holter S, Sherman PM, Gallinger S: The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations. Am J Gastroenterol; 2010 Nov;105(11):2449-56
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  • More than one-third of patients had multiple colorectal adenomas (>10 polyps).
  • This distinct phenotype includes multiple adenomatous polyps and CAL skin lesions.

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  • (PMID = 20531397.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Berger BM, Schroy PC 3rd, Rosenberg JL, Lai-Goldman M, Eisenberg M, Brown T, Rochelle RB, Billings PR: Colorectal cancer screening using stool DNA analysis in clinical practice: early clinical experience with respect to patient acceptance and colonoscopic follow-up of abnormal tests. Clin Colorectal Cancer; 2006 Jan;5(5):338-43
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  • An abnormal stool DNA test correlated with a colonoscopically demonstrable abnormality in 49% of cases (34 of 69).
  • Abnormal findings, including CRC in 3 patients (4%; 1 with Dukes A and 2 with Dukes B disease), single or multiple adenomatous polyps in 23 patients (33%), hyperplastic polyps in 3 patients (4%), and colitis in 5 patients (7%).
  • CONCLUSION: Stool DNA testing provides an acceptable noninvasive alternative for CRC screening that can identify early-stage CRCs and adenomatous polyps in routine clinical practice.


16. Jo WS, Bandipalliam P, Shannon KM, Niendorf KB, Chan-Smutko G, Hur C, Syngal S, Chung DC: Correlation of polyp number and family history of colon cancer with germline MYH mutations. Clin Gastroenterol Hepatol; 2005 Oct;3(10):1022-8
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  • [Title] Correlation of polyp number and family history of colon cancer with germline MYH mutations.
  • BACKGROUND & AIMS: Affected individuals with biallelic MYH mutations are believed to display multiple adenomatous polyps without evidence of vertical transmission.
  • Our goal was to determine the detection rate of germline MYH mutations in a high-risk gastrointestinal cancer clinic population by using polyp number as a selection criterion.
  • RESULTS: Among 45 patients with more than 15 adenomatous polyps not diagnosed with familial adenomatous polyposis, 7 (15.6%) had biallelic MYH mutations.
  • Both had young-onset colorectal cancer (age, <50 y) with fewer than 15 polyps.
  • CONCLUSIONS: Most individuals with MYH mutations exhibit multiple adenomatous polyps.

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  • (PMID = 16234049.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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17. Greaves WO, Bhattacharya B: Hepatic adenomatosis. Arch Pathol Lab Med; 2008 Dec;132(12):1951-5
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  • [Title] Hepatic adenomatosis.
  • Hepatic adenomatosis was first described in 1985 by Flejou et al as multiple adenomas, arbitrarily more than 10, in an otherwise normal liver parenchyma.

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  • (PMID = 19061298.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hepatocyte Nuclear Factor 1-alpha
  • [Number-of-references] 30
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18. Wijn MA, Keller JJ, Brand HS: [Oral and maxillofacial manifestations of familial adenomatosis polyposis. Gardner's syndrome]. Ned Tijdschr Tandheelkd; 2005 Sep;112(9):340-4
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  • [Title] [Oral and maxillofacial manifestations of familial adenomatosis polyposis. Gardner's syndrome].
  • [Transliterated title] Orale en maxillofaciale afwijkingen bij familiaire adenomateuze polyposis. Het syndroom van Gardner.
  • Patients suffering from familial adenomatosis polyposis develop multiple pre-malignant gastrointestinal polyps and are at high risk of developing colon cancer.
  • The combination of extra-intestinal manifestations and familial adenomatosis polyposis is named Gardner's syndrome.
  • [MeSH-minor] Abnormalities, Multiple / genetics. Humans. Intestinal Polyps / epidemiology. Intestinal Polyps / genetics. Intestinal Polyps / pathology. Tooth, Impacted / epidemiology. Tooth, Impacted / etiology. Tooth, Impacted / genetics. Tooth, Supernumerary / epidemiology. Tooth, Supernumerary / etiology. Tooth, Supernumerary / genetics

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  • (PMID = 16184913.001).
  • [ISSN] 0028-2200
  • [Journal-full-title] Nederlands tijdschrift voor tandheelkunde
  • [ISO-abbreviation] Ned Tijdschr Tandheelkd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 30
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19. Lepistö A, Kiviluoto T, Halttunen J, Järvinen HJ: Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposis. Endoscopy; 2009 Jun;41(6):504-9
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  • [Title] Surveillance and treatment of duodenal adenomatosis in familial adenomatous polyposis.
  • BACKGROUND AND STUDY AIMS: Patients with familial adenomatous polyposis (FAP) are at increased risk for duodenal cancer whereas colorectal cancer is largely prevented by prophylactic colectomy.
  • We analyzed the results of endoscopic surveillance and different treatment modalities of duodenal adenomatosis in patients with FAP.
  • The cumulative incidences of duodenal adenomatosis and severe dysplasia and cancer were calculated using Kaplan-Meier analysis.
  • RESULTS: By the age of 60 years, the cumulative incidence was 80% for any adenomatosis and 23% for severe dysplasia or cancer.
  • CONCLUSIONS: The high incidence of severe dysplasia and cancer in duodenal polyps suggests that endoscopic surveillance is essential.
  • High-risk patients with Spigelman IV adenomatosis or adenomas with persisting severe dysplasia should undergo surgery with pylorus-preserving pancreaticoduodenectomy before invasive cancer develops.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / epidemiology. Intestinal Polyps / complications


20. Veteläinen R, Erdogan D, de Graaf W, ten Kate F, Jansen PL, Gouma DJ, van Gulik TM: Liver adenomatosis: re-evaluation of aetiology and management. Liver Int; 2008 Apr;28(4):499-508
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  • [Title] Liver adenomatosis: re-evaluation of aetiology and management.
  • BACKGROUND: Liver adenomatosis (LA) is a rare benign parenchymal liver disease with unknown aetiology.
  • CONCLUSION: Liver adenomatosis is a progressive, benign parenchymal disease mainly occurring in females.

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  • [CommentIn] Liver Int. 2009 Jan;29(1):142 [18828785.001]
  • (PMID = 18339077.001).
  • [ISSN] 1478-3231
  • [Journal-full-title] Liver international : official journal of the International Association for the Study of the Liver
  • [ISO-abbreviation] Liver Int.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 57
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21. Beytut E, Sözmen M, Ergínsoy S: Immunohistochemical detection of pulmonary surfactant proteins and retroviral antigens in the lungs of sheep with pulmonary adenomatosis. J Comp Pathol; 2009 Jan;140(1):43-53
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  • [Title] Immunohistochemical detection of pulmonary surfactant proteins and retroviral antigens in the lungs of sheep with pulmonary adenomatosis.
  • The lungs and mediastinal and bronchial lymph nodes from 26 sheep with ovine pulmonary adenomatosis (OPA) were examined.
  • [MeSH-major] Antigens, Viral / metabolism. Lung / metabolism. Pulmonary Adenomatosis, Ovine / metabolism. Pulmonary Surfactant-Associated Protein A / metabolism. Pulmonary Surfactant-Associated Protein B / metabolism. Pulmonary Surfactant-Associated Protein C / metabolism. Retroviridae / immunology

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  • (PMID = 19081577.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, Viral; 0 / Proliferating Cell Nuclear Antigen; 0 / Pulmonary Surfactant-Associated Protein A; 0 / Pulmonary Surfactant-Associated Protein B; 0 / Pulmonary Surfactant-Associated Protein C; 9060-09-7 / Uteroglobin
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22. Berkhout M, Roelofs HM, te Morsche RH, Dekker E, van Krieken JH, Nagengast FM, Peters WH: Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. Br J Surg; 2008 Apr;95(4):499-505
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  • [Title] Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.
  • BACKGROUND: Patients with familial adenomatous polyposis (FAP) are at high risk of developing duodenal adenomas and carcinomas.
  • Besides germline mutations in the adenomatous polyposis coli (APC) gene, additional factors may influence the age of onset and number of duodenal adenomas.
  • The polymorphisms investigated had no predictive value for the severity of duodenal adenomatosis in patients with FAP.
  • CONCLUSION: Although the variant genotypes of UGT1A3 were less common in patients with FAP than in those without, this did not modulate the severity of duodenal adenomatosis.
  • [MeSH-major] Adenomatous Polyposis Coli / enzymology. Duodenal Neoplasms / enzymology. Genes, APC. Glucuronosyltransferase / genetics. Glutathione Transferase / genetics. Polymorphism, Genetic / genetics


23. Müller MW, Dahmen R, Köninger J, Michalski CW, Hinz U, Hartel M, Kadmon M, Kleeff J, Büchler MW, Friess H: Is there an advantage in performing a pancreas-preserving total duodenectomy in duodenal adenomatosis? Am J Surg; 2008 Jun;195(6):741-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is there an advantage in performing a pancreas-preserving total duodenectomy in duodenal adenomatosis?
  • BACKGROUND: Duodenal adenomatosis is a premalignant condition often not treatable by local resection or endoscopy.
  • Since the introduction of pancreas-preserving total duodenectomy (PPTD), the question has arisen whether a pp-Whipple resection is still needed to treat duodenal adenomatosis.
  • PATIENTS AND METHODS: In a 5-year period 23 PPTDs were performed for duodenal adenomatosis.
  • CONCLUSIONS: PPTD is a safe surgical procedure for duodenal adenomatosis that avoids pancreatic head resection, provides high quality of life, and shows advantages over the pp-Whipple procedure.

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  • (PMID = 18436175.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Giovanoli O, Heim M, Terracciano L, Bongartz G, Ledermann HP: MRI of hepatic adenomatosis: initial observations with gadoxetic acid contrast agent in three patients. AJR Am J Roentgenol; 2008 May;190(5):W290-3
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  • [Title] MRI of hepatic adenomatosis: initial observations with gadoxetic acid contrast agent in three patients.
  • OBJECTIVE: The purpose of our study was to describe the MR signal characteristics of histologically proven liver adenomatosis in three patients using gadoxetic acid, a newly developed liver-specific MR contrast agent.

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  • (PMID = 18430814.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / gadolinium ethoxybenzyl DTPA; K2I13DR72L / Gadolinium DTPA
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25. Dekker E, Boparai KS, Poley JW, Mathus-Vliegen EM, Offerhaus GJ, Kuipers EJ, Fockens P, Dees J: High resolution endoscopy and the additional value of chromoendoscopy in the evaluation of duodenal adenomatosis in patients with familial adenomatous polyposis. Endoscopy; 2009 Aug;41(8):666-9
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  • [Title] High resolution endoscopy and the additional value of chromoendoscopy in the evaluation of duodenal adenomatosis in patients with familial adenomatous polyposis.
  • BACKGROUND AND STUDY AIM: Duodenal polyposis occurs in approximately 90 % of patients with familial adenomatous polyposis (FAP) and 5 % - 10 % develop duodenal cancer.
  • Novel imaging techniques may improve evaluation of duodenal polyposis using the Spigelman classification.
  • We aimed to analyze the value of high resolution endoscopy (HRE) and the additional value of chromoendoscopy in the evaluation of duodenal polyposis in FAP.
  • After number and size of adenomas had been scored, indigo carmine 0.5 % was sprayed onto the mucosa, polyps were scored again and biopsies taken from the larger lesions.
  • Therefore, a combination of forward-viewing HRE and chromoendoscopy with side-viewing endoscopy for the periampullary region seems useful for surveillance of duodenal adenomatosis in FAP.
  • [MeSH-major] Adenoma / diagnosis. Adenomatous Polyposis Coli / complications. Duodenal Neoplasms / diagnosis. Duodenoscopy / methods


26. Kobayashi S, Sakaguchi H, Takatsuka M, Suekane T, Iwai S, Morikawa H, Enomoto M, Tamori A, Kawada N: Two cases of hepatocellular adenomatosis treated with transcatheter arterial embolization. Hepatol Int; 2009 Jun;3(2):416-20

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  • [Title] Two cases of hepatocellular adenomatosis treated with transcatheter arterial embolization.
  • Surgical resection is considered to be the best choice of treatment, when adenomas are increasing in size, while resection is difficult to perform when multiple adenomas develop throughout the liver.
  • Here, we report two cases of multiple hepatocellular adenomatosis.
  • These cases suggest that TAE is an effective treatment of hepatocellular adenomatosis.

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  • (PMID = 19669369.001).
  • [ISSN] 1936-0533
  • [Journal-full-title] Hepatology international
  • [ISO-abbreviation] Hepatol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2716763
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27. Bambha K, Nagorney D, Sanderson S, Gores GJ: Hepatic adenomatosis in a young woman with glucose intolerance. Nat Clin Pract Gastroenterol Hepatol; 2006 Sep;3(9):526-31; quiz (following 531)
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  • [Title] Hepatic adenomatosis in a young woman with glucose intolerance.
  • DIAGNOSIS: Hepatic adenomatosis.

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  • (PMID = 16951669.001).
  • [ISSN] 1743-4378
  • [Journal-full-title] Nature clinical practice. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Clin Pract Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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28. Lewin M, Handra-Luca A, Arrivé L, Wendum D, Paradis V, Bridel E, Fléjou JF, Belghiti J, Tubiana JM, Vilgrain V: Liver adenomatosis: classification of MR imaging features and comparison with pathologic findings. Radiology; 2006 Nov;241(2):433-40
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  • [Title] Liver adenomatosis: classification of MR imaging features and comparison with pathologic findings.
  • PURPOSE: To retrospectively compare the clinical manifestation and magnetic resonance (MR) imaging features of liver adenomatosis with pathologic findings.
  • Twenty patients were classified on the basis of pathologic findings into three groups: those with a steatotic, those with a peliotic, and those with a mixed (steatotic and peliotic) form of liver adenomatosis.
  • CONCLUSION: There are three patterns of MR imaging features of liver adenomatosis that are associated with three pathologic forms (steatotic, peliotic, and mixed).

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  • (PMID = 16966481.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 0 / gadoterate meglumine; 6HG8UB2MUY / Meglumine
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29. Arvind N, Duraimurugan D, Rajkumar JS: Hepatic adenomatosis--a rare double complication of multiple adenoma rupture and malignant transformation. Indian J Gastroenterol; 2006 Jul-Aug;25(4):209-10
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  • [Title] Hepatic adenomatosis--a rare double complication of multiple adenoma rupture and malignant transformation.
  • Hepatic adenomatosis (HA) is a rare disorder that is susceptible to hemorrhagic complications and, rarely, to malignant transformation.

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  • (PMID = 16974041.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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30. Di Sandro S, Slim AO, Lauterio A, Giacomoni A, Mangoni I, Aseni P, Pirotta V, Aldumour A, Mihaylov P, De Carlis L: Liver adenomatosis: a rare indication for living donor liver transplantation. Transplant Proc; 2009 May;41(4):1375-7
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  • [Title] Liver adenomatosis: a rare indication for living donor liver transplantation.
  • Liver adenomatosis (LA) is a rare benign disease of the liver with unclear pathogenesis, which is characterized by multiple hepatic adenomas.
  • A 48-year-old woman developed multiple liver adenomas.
  • Thirty-four months later, she developed recurrence of multiple hepatic adenomas and 2 nodules were highly suspect for hepatocellular carcinoma.


31. Henopp T, Anlauf M, Schmitt A, Schlenger R, Zalatnai A, Couvelard A, Ruszniewski P, Schaps KP, Jonkers YM, Speel EJ, Pellegata NS, Heitz PU, Komminoth P, Perren A, Klöppel G: Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas. J Clin Endocrinol Metab; 2009 Jan;94(1):213-7
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  • [Title] Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas.
  • BACKGROUND: Glucagon-producing tumors are either solitary neoplasms of the pancreas, occasionally associated with a glucagonoma syndrome, or multiple neoplasms associated with multiple endocrine neoplasia type 1 (MEN1).
  • METHODS: Pancreatic tissue from four patients showing multiple neuroendocrine microadenomas and in two cases also macrotumors were screened for hormones using immunohistochemical and morphometric methods.
  • CONCLUSIONS: The findings are sufficiently distinctive to suggest a new neoplastic disease of the endocrine pancreas that we recommend calling glucagon cell adenomatosis.

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  • (PMID = 18957496.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MEN1 protein, human; 0 / Proto-Oncogene Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; 9007-92-5 / Glucagon; EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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32. Kim YT, Park JY, Jeon YK, Park SJ, Song JY, Kang CH, Sung SW, Kim JH: Aberrant promoter CpG island hypermethylation of the adenomatosis polyposis coli gene can serve as a good prognostic factor by affecting lymph node metastasis in squamous cell carcinoma of the esophagus. Dis Esophagus; 2009;22(2):143-50
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  • [Title] Aberrant promoter CpG island hypermethylation of the adenomatosis polyposis coli gene can serve as a good prognostic factor by affecting lymph node metastasis in squamous cell carcinoma of the esophagus.
  • CpG island hypermethylations were observed in 10% for p16, 34% for RARbetaP2, 46% for adenomatosis polyposis coli (APC), 14% for RASSF1A, 84% for FHIT, and 8% for hMLH1.

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  • (PMID = 18847451.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. Babaoglu K, Binnetoglu FK, Aydoğan A, Altun G, Gürbüz Y, Inan N, Corapçioğlu F: Hepatic adenomatosis in a 7-year-old child treated earlier with a Fontan procedure. Pediatr Cardiol; 2010 Aug;31(6):861-4
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  • [Title] Hepatic adenomatosis in a 7-year-old child treated earlier with a Fontan procedure.
  • However, hepatic adenoma and hepatic adenomatosis (HA) are not well-known pathologies during the course of cardiac hepatopathy.
  • Hepatic adenomatosis was diagnosed on the basis of magnetic resonance imaging (MRI) and MRI-guided liver biopsy.
  • To the best of the authors' knowledge, this case involved the youngest patient with hepatocellular adenomatosis documented in the literature.

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  • (PMID = 20204345.001).
  • [ISSN] 1432-1971
  • [Journal-full-title] Pediatric cardiology
  • [ISO-abbreviation] Pediatr Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Svrcek M, Jeannot E, Arrivé L, Poupon R, Fromont G, Fléjou JF, Zucman-Rossi J, Bouchard P, Wendum D: Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis. Eur J Endocrinol; 2007 Jun;156(6):617-21
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  • [Title] Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis.
  • On the contrary, their contribution to liver adenomatosis (LA) development is still a debatable issue.

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  • (PMID = 17535860.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Synthetic; 0 / Hepatocyte Nuclear Factor 1-alpha; 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; N2Z8ALG4U5 / Lynestrenol
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35. Wellen JR, Anderson CD, Doyle M, Shenoy S, Nadler M, Turmelle Y, Shepherd R, Chapman WC, Lowell JA: The role of liver transplantation for hepatic adenomatosis in the pediatric population: case report and review of the literature. Pediatr Transplant; 2010 May;14(3):E16-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of liver transplantation for hepatic adenomatosis in the pediatric population: case report and review of the literature.
  • These tumors are often solitary but can also be multiple in which case this is referred to as hepatic adenomatosis (HA).

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  • (PMID = 19490491.001).
  • [ISSN] 1399-3046
  • [Journal-full-title] Pediatric transplantation
  • [ISO-abbreviation] Pediatr Transplant
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 12
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36. Luo JR, Liu XH, Yu QY, Zhang SQ, Zhou JH, Ma XE: [A specific PCR assay and a nested PCR assay for the screening of ovine pulmonary adenomatosis]. Bing Du Xue Bao; 2009 Mar;25(2):125-30
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  • [Title] [A specific PCR assay and a nested PCR assay for the screening of ovine pulmonary adenomatosis].
  • Ovine pulmonary adenomatosis (OPA) is a naturally occurring contagious lung tumor of sheep which was caused by an exogenous retrovirus of sheep, jaagsiekte retrovirus (JSRV).

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  • (PMID = 19678567.001).
  • [ISSN] 1000-8721
  • [Journal-full-title] Bing du xue bao = Chinese journal of virology
  • [ISO-abbreviation] Bing Du Xue Bao
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Viral
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37. Woldemeskel M, Tibbo M: Pulmonary adenomatosis and maedi-visna in Ethiopian central highland sheep: a microscopic study. Trop Anim Health Prod; 2010 Jun;42(5):995-9

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  • [Title] Pulmonary adenomatosis and maedi-visna in Ethiopian central highland sheep: a microscopic study.
  • Lesions compatible with sheep pulmonary adenomatosis (SPA; 8/35, 22.8%), and maedi-visna (MV; 9/35, 25.7%) were recorded only in sheep from the central highlands.
  • [MeSH-major] Pulmonary Adenomatosis, Ovine / epidemiology. Sheep Diseases / epidemiology. Visna / epidemiology. Visna-maedi virus / isolation & purification

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  • (PMID = 20024674.001).
  • [ISSN] 1573-7438
  • [Journal-full-title] Tropical animal health and production
  • [ISO-abbreviation] Trop Anim Health Prod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Ulu EM, Uyuşur A, Ekici Y, Hunca C, Coşkun M: Multidetector CT findings of spontaneous rupture of hepatic adenoma in a patient with hepatic adenomatosis. Diagn Interv Radiol; 2009 Jun;15(2):135-8
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  • [Title] Multidetector CT findings of spontaneous rupture of hepatic adenoma in a patient with hepatic adenomatosis.
  • Hepatic adenomatosis (HA) is characterized by more than 10 adenomas in the liver, frequently scattered within both lobes.
  • On follow-up CT examination, a large adenoma was clearly visualized at the site of the previous hematoma.

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  • (PMID = 19517384.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Contrast Media
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39. Beaton MD, Taylor B, Driman D, Ainsworth P, Adams PC: Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation? Can J Gastroenterol; 2008 Jul;22(7):634-6
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  • [Title] Colonic interposition in a woman with attenuated familial adenomatosis polyposis: does the location of the colon affect polyp formation?
  • Attenuated familial adenomatous polyposis (AFAP) is a rare but well-established cause of colorectal carcinoma and multiple polyps.
  • While she had developed adenomatous polyps in her native cecum, there was no evidence of polyps or cancer in the segment of large intestine interposed between her upper esophagus and stomach.
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Colonic Polyps / pathology

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  • [Cites] Gut. 1999 Dec;45(6):829-33 [10562580.001]
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  • (PMID = 18629394.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2661270
  •  go-up   go-down


40. Elander N, Zhou J, Ungerbäck J, Dimberg J, Söderkvist P: Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. Mol Carcinog; 2009 May;48(5):401-7
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer.
  • Previous reports reveal that defects of the tumor suppressor adenomatosis polyposis coli (APC) contribute to COX-2 upregulation in colon tumor cells.

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  • (PMID = 19035518.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Small Interfering; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.3 / prostaglandin-E synthase
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41. Moya Herráiz A, Torres-Quevedo R, Mir Pallardó J: [Liver transplantation in patients with benign hepatic lesions]. Cir Esp; 2008 Aug;84(2):60-6
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  • We present a review of the subject, commenting on the aspects that have been subsidiary to liver transplantation, of which are highlighted: adenomatosis, polycystosis and hepatic epithelioid haemangioendothelioma (although this process may be a low to intermediate malignant grade).

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  • (PMID = 18682182.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 73
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42. Alese OB, Irabor DO: Adenomatous polyposis coli in an elderly female nigerian. Ghana Med J; 2009 Sep;43(3):139-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenomatous polyposis coli in an elderly female nigerian.
  • Colorectal cancer is reported to occur in lower rates in Africans and some of the reasons adduced include a rarity of polyposis coli syndromes.
  • Only two cases of polyposis coli have been documented in Nigeria in the last 15 years.
  • The present case is an elderly lady who had radiologic and colonoscopic evidence of multiple colonic polyps.
  • She had a colonic resection and the histology was reported as multiple polyposis coli, follicular hyperplasia and submucosal fibrosis in the appendix, and reactive hyperplasia in the mesenteric lymph nodes.
  • This is the first case report of polyposis coli in a living elderly patient in Nigeria.

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  • (PMID = 20126328.001).
  • [ISSN] 0016-9560
  • [Journal-full-title] Ghana medical journal
  • [ISO-abbreviation] Ghana Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ghana
  • [Other-IDs] NLM/ PMC2810243
  • [Keywords] NOTNLM ; Nigeria / Polyposis coli / familial adenomatous polyposis / malignancy
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43. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today; 2008;38(5):440-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
  • We report a case of relapsing pancreatitis in familial adenomatous polyposis (FAP) with severe duodenal adenomatosis (Spigelman's stage IV).
  • Upper endoscopy showed multiple duodenal adenomas including carcinoma involving the papilla of Vater.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications. Ampulla of Vater. Common Bile Duct Neoplasms / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / etiology


44. Dawson S, Else RW, Rhind SM, Collie DD: Diagnostic value of cytology of bronchoalveolar fluid for lung diseases of sheep. Vet Rec; 2005 Oct 8;157(15):433-6
MedlinePlus Health Information. consumer health - Lung Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The diffuse lung diseases, maedi and adenomatosis, were both characterised by an increase in overall cellularity and by increases in the percentages of lymphocytes and neutrophils, respectively.

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  • (PMID = 16215243.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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45. Haase M, Willenberg HS: Adrenal cortical tumors and multiple endocrine neoplasia-related syndromes. Minerva Endocrinol; 2009 Jun;34(2):123-35
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  • [Title] Adrenal cortical tumors and multiple endocrine neoplasia-related syndromes.
  • These syndromes and diseases include the Carney complex, the McCune-Albright syndrome, multiple endocrine neoplasia type 1, familial adenomatosis coli, congenital adrenal hyperplasia, familial forms of primary aldosteronism, the Beckwith-Wiedemann syndrome, and the Li-Fraumeni syndrome.
  • [MeSH-major] Adrenal Cortex Neoplasms / genetics. Multiple Endocrine Neoplasia / genetics. Mutation
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Adrenal Hyperplasia, Congenital / genetics. Beckwith-Wiedemann Syndrome / genetics. Fibrous Dysplasia, Polyostotic / genetics. Heart Neoplasms / genetics. Humans. Hyperaldosteronism / genetics. Li-Fraumeni Syndrome / genetics. Multiple Endocrine Neoplasia Type 1 / genetics. Myxoma / genetics. Pigmentation Disorders / genetics

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  • (PMID = 19471237.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Italy
  • [Number-of-references] 100
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46. Madani M, Madani F: Gardner's syndrome presenting with dental complaints. Arch Iran Med; 2007 Oct;10(4):535-9
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  • There are three distinctive features associated with this syndrome: familial intestinal polyposis or adenomatosis, surface tumors of hard tissues particularly osteoma in the skull, maxillae, and mandible, and finally surface tumors of the soft tissue.
  • The intestinal polyps have a 100% risk of undergoing malignant transformation if not treated.
  • In this article an 18-year-old male patient with previously undiagnosed Gardner's syndrome who presented for removal of multiple impacted and unerupted teeth is reported to illustrate the importance of early detection and proper referral.

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  • (PMID = 17903064.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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47. Plevová P, Drobcinská L, Stekrová J, Silhánová E: [Single nucleotide c.645+32c&gt;T substitution in the APC gene is a non-pathogenic polymorphism appearing in about 16% of the Czech population]. Cas Lek Cesk; 2008;147(5):266-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Familial adenomatous polyposis is an autosomal dominant disease characterised by predisposition to colon polyposis and colorectal cancer and caused by germline mutations in the APC gene.
  • The aim of the study was to establish the frequency of c.645+32C>T substitution in intron 5 of the APC gene in patients with multiple colon polyposis and in the general population and to determine if this substitution is a nonpathogenic polymorphism or a pathogenic mutation associated with multiple polyposis coli.
  • METHODS AND RESULTS: The frequency of c.645+32C>T substitution in the APC gene was established in 170 patients with the clinical phenotype of familial adenomatous polyposis or its attenuated form using denaturating gradient gel electrophoresis and direct sequencing.
  • The c.645+32C>T substitution was detected in 27 of 170 patients with multiple colon polyposis (i.e. 15.9%).
  • The difference between patients with polyposis and the control group was not statistically significant (p = 0.979; chí-square test).
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Genes, APC. Polymorphism, Single Nucleotide

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  • (PMID = 18630182.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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48. Declich P, Carneiro F, Omazzi B, Tavani E, Grassini R, Ferrara A, Bortoli A, Bellone S, Gozzini C, Prada A: Immunophenotype of sporadic and familial adenomatous polyposis associated fundic gland polyps: a mucin and MIB1 study. Pol J Pathol; 2006;57(3):141-8
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  • [Title] Immunophenotype of sporadic and familial adenomatous polyposis associated fundic gland polyps: a mucin and MIB1 study.
  • BACKGROUND: Fundic Gland Polyps (FGPs) are small sessile (2-5 mm) usually multiple polyps arising in the gastric, acid-secreting mucosa, described both in a sporadic form, prevalently in middle aged females, and associated with familial adenomatosis coli (FAP)-Gardner's syndrome and their attenuated variants (syndromic form).
  • AIMS: We performed an immunohistochemical study on 5 syndromic (4 cases without and 1 case with dysplasia) and 28 sporadic FGPs, using monoclonal antibodies (MoAbs) against normal epitopes of fundic mucosa (Ck20, the surface gastric mucin M1, EMA, ChA), H. pylori and HLA-DR(Ia) antigens, CEA and mucin epitopes, and the Ki67 (MIB1) proliferation antigen, in order to establish the immunophenotype of FGPs; find any possible differences between sporadic and syndromic polyps.
  • The only difference we found between syndromic and sporadic polyps was a statistically significant enhanced MIB1-labelling index expression by syndromic FGPs, further enhanced in the syndromic FGP with dysplasia.
  • [MeSH-major] Adenomatous Polyposis Coli / metabolism. Adenomatous Polyps / metabolism. Gastric Fundus / metabolism. Ki-67 Antigen / metabolism. Mucins / metabolism

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  • (PMID = 17219741.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Mucins
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49. Kalimutho M, Blanco Gdel V, Gravina P, Cretella M, Mannucci L, Mannisi E, Formosa A, Pallone F, Federici G, Bernardini S: Quantitative denaturing high performance liquid chromatography (Q-dHPLC) detection of APC long DNA in faeces from patients with colorectal cancer. Clin Chem Lab Med; 2010 Sep;48(9):1303-11
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  • Adenomatosis polyposis coli (APC)-Long-DNA and its mutations were analysed using dHPLC and the Sanger sequencing method.

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  • (PMID = 20504269.001).
  • [ISSN] 1437-4331
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins; 9007-49-2 / DNA
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50. Ruys AT, Alderlieste YA, Gouma DJ, Dekker E, Mathus-Vliegen EM: Jejunal cancer in patients with familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2010 Aug;8(8):731-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Jejunal cancer in patients with familial adenomatous polyposis.
  • BACKGROUND & AIMS: Familial adenomatous polyposis (FAP) is an inherited disease affecting approximately 1:10,000 newborns, characterized by the formation of numerous adenomas in the digestive tract.
  • RESULTS: Three patients with FAP aged 71, 57, and 59 years developed advanced duodenal adenomatosis and a jejunal carcinoma, which was associated with poor prognosis in 2 patients.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Adenomatous Polyposis Coli / complications. Jejunal Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Clin Gastroenterol Hepatol. 2010 Oct;8(10):904 [20621624.001]
  • (PMID = 20399906.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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51. Belingheri M, Ghio L, Sala A, Menni F, Trespidi L, Ferraresso M, Berardinelli L, Rossi G, Edefonti A, Parini R: Combined liver-kidney transplantation in glycogen storage disease Ia: a case beyond the guidelines. Liver Transpl; 2007 May;13(5):762-4
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  • Liver transplantation is the only radical treatment, for which the main indications are hepatic adenomatosis, hepatocellular carcinoma, or severe hepatic dysfunction.


52. Seldin DC, Landesman-Bollag E, Farago M, Currier N, Lou D, Dominguez I: CK2 as a positive regulator of Wnt signalling and tumourigenesis. Mol Cell Biochem; 2005 Jun;274(1-2):63-7
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  • Multiple signalling and oncogene pathways could be regulated by CK2 in this process.
  • Inactivating mutations in the adenomatosis polyposis coli (APC) gene, which encodes a carrier protein for beta-catenin, or stabilizing mutations in beta-catenin itself, frequently occur in human tumours.

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  • (PMID = 16342409.001).
  • [ISSN] 0300-8177
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / P01 ES11624; United States / NCI NIH HHS / CA / R01 CA71796; United States / NCI NIH HHS / CA / T32 CA064070
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin; EC 2.7.11.1 / Casein Kinase II; EC 2.7.11.26 / Glycogen Synthase Kinase 3
  • [Number-of-references] 16
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53. Ajith Kumar VK, Gold JA, Mallon E, Thomas S, Hodgson SV: Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin. Fam Cancer; 2008;7(2):187-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin.
  • MYH associated polyposis is an autosomal recessive polyposis syndrome with a high risk of large bowel cancer, caused by mutations in the DNA repair gene MYH.
  • Muir Torre Syndrome is the association of internal malignancies with sebaceous gland tumours; Lynch Syndrome/Hereditary Non Polyposis Cancer is the best known cause.
  • There has been a previous report of sebaceous gland tumours in an Italian patient with MYH associated polyposis.
  • We describe a man of Indian (Gujarati) descent who has MYH associated polyposis and multiple sebaceous adenomas of the skin.
  • [MeSH-major] Adenoma / genetics. Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Sebaceous Gland Neoplasms / genetics

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  • (PMID = 17874208.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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54. Shemerovskiĭ KA: [Constipation--a risk factor for colorectal cancer]. Klin Med (Mosk); 2005;83(12):60-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The morphological signs of large bowel pre-cancer (dysplasia, adenomatosis, polyposis) seem to be secondary to the primary functional disorder of the circadian rhythm.
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / etiology. Circadian Rhythm. Colonic Polyps / epidemiology. Colonic Polyps / etiology. Gastrointestinal Diseases / epidemiology. Humans. Precancerous Conditions / epidemiology. Precancerous Conditions / etiology. Quality of Life. Risk Factors. Russia / epidemiology

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  • (PMID = 16502728.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 25
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55. Bober A: Passing it on: should health care professionals be permitted to disclose patients' genetic information to their reproductive partners? J Law Med; 2006 Nov;14(2):262-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The issue is addressed with reference to four genetic disorders (Huntington Disease, Familial Adenomatous Polyposis, Multiple Endocrine Neoplasia Type 2A and Cystic Fibrosis) which illustrate differences in inheritance traits and availability of effective treatments.
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Australia. Cystic Fibrosis / genetics. Humans. Huntington Disease / genetics. Multiple Endocrine Neoplasia Type 2a / genetics

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  • (PMID = 17153530.001).
  • [ISSN] 1320-159X
  • [Journal-full-title] Journal of law and medicine
  • [ISO-abbreviation] J Law Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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56. Sugita A, Koganei K, Kimura H, Yamada K, Futatuki R, Kitoh F, Fukushima T: [Reconstruction of proctocolectomy: which is the best surgical procedure?]. Nihon Geka Gakkai Zasshi; 2008 Sep;109(5):269-73

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  • Total proctocolectomy is commonly performed in patients with ulcerative colitis or familial adenomatosis coli.
  • Postoperative cancer surveillance colonoscopy is recommended in patients with stapled IPAA, and patients with IPAA have also at risk for cancer in the anastomotic site, although at very low incidence.

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  • (PMID = 18939461.001).
  • [ISSN] 0301-4894
  • [Journal-full-title] Nihon Geka Gakkai zasshi
  • [ISO-abbreviation] Nihon Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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57. Karoui M, Tresallet C, Brouquet A, Radvanyi H, Penna C: [Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer]. J Chir (Paris); 2007 Jan-Feb;144(1):13-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The two best defined forms of inherited CRC-familial multiple polyposis (FMP) and Hereditary Non-Polyposis Colon Cancer (HNPCC) account respectively for<1% and 2-3% of CRC.
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Environment. Genes, Tumor Suppressor. Humans. Mutation / genetics. Penetrance. Peutz-Jeghers Syndrome / genetics

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  • (PMID = 17369756.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 15
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58. Zlobec I, Terracciano L, Jass JR, Lugli A: Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer. Virchows Arch; 2007 Oct;451(4):763-9
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  • A tissue microarray of 1,197 colorectal cancers was immunostained for p53, Her2/neu, epidermal growth factor receptor (EGFR), adenomatosis polyposis coli (APC), and beta-catenin.
  • [MeSH-minor] Adenomatous Polyposis Coli Protein / metabolism. Humans. Multivariate Analysis. Neoplasm Staging. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / metabolism. Tumor Suppressor Protein p53 / metabolism. beta Catenin / metabolism

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  • (PMID = 17674041.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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59. Vivarelli M, Lauro A, Cucchetti A, D'Errico A, Pironi L, Pinna AD: Effect of total enterectomy, pancreatectomy, and portal vein ligation on liver function and histology: a case report. Transplant Proc; 2007 Jan-Feb;39(1):300-2

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  • Herein a 32-year-old woman with familial adenomatous polyposis and multiple desmoid tumors involving the mesentery and the retroperitoneum underwent total enterectomy and pancreatectomy followed by en bloc transplantation of the stomach, small bowel, and pancreas.

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  • (PMID = 17275528.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Laurent-Puig P, Zucman-Rossi J: Genetics of hepatocellular tumors. Oncogene; 2006 Jun 26;25(27):3778-86
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  • It includes integration of hepatitis B virus (HBV) DNA, R249S TP53 (tumor protein p53) mutation in aflatoxin B1-exposed patients, KRAS mutations related to vinyl chloride exposure, hepatocyte nuclear factor 1alpha (HNF1alpha) mutations associated to hepatocellular adenomas and adenomatosis polyposis coli (APC) germline mutations predisposing to hepatoblastomas.


61. Kim JC, Cho YK, Roh SA, Yu CS, Gong G, Jang SJ, Kim SY, Kim YS: Individual tumorigenesis pathways of sporadic colorectal adenocarcinomas are associated with the biological behavior of tumors. Cancer Sci; 2008 Jul;99(7):1348-54
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  • Individual steps in the tumorigenesis pathway, that is, adenomatosis polyposis coli (APC), Wnt-activated, base excision repair mutations, mismatch repair defects, RAF-mediated, transforming growth factor (TGF)-beta-suppressed, bone morphogenic protein (BMP)-suppressed, and p53 alterations, were examined in terms of genetic and epigenetic changes, as well as protein expression.

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  • [ErratumIn] Cancer Sci. 2008 Jul;99(7):1499
  • (PMID = 18422752.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.11.1 / raf Kinases
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62. Stephen JK, Chen KM, Raitanen M, Grénman S, Worsham MJ: DNA hypermethylation profiles in squamous cell carcinoma of the vulva. Int J Gynecol Pathol; 2009 Jan;28(1):63-75
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  • Of the 22 tumor suppressor genes examined, aberrant methylation was observed for 9 genes: tumor protein p73 (TP73), fragile histidine triad (FHIT), von Hippel-Lindau (VHL), adenomatosis polyposis coli (APC), estrogen receptor 1 (ESR1), cyclin-dependent kinase inhibitor 2B (CDKN2B), death-associated protein kinase 1 (DAPK1), glutathione S-transferase pi (GSTP1), and immunoglobin superfamily, member 4 (IGSF4).
  • Frequent genetic alterations of loss and gain of gene copy number included gain of GSTP1 and multiple endocrine neoplasia type 1 (MEN1), and loss of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) and IGSF4 in over 50% of the squamous cell carcinoma of the vulva cell lines.

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  • (PMID = 19047905.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE015990; United States / NIDCR NIH HHS / DE / R01 DE015990-05; United States / NIDCR NIH HHS / DE / DE 15990
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS52427; NLM/ PMC2605778
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63. Kaufmann C, Brechbühl M, Oevermann A, Müller S, Zimmer K, Schönmann M, Leroux C, Weibel D, Bertoni G: [Enzootic nasal adenocarcinoma in a dairy sheep flock]. Schweiz Arch Tierheilkd; 2008 Jun;150(6):297-302
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  • The significance of the disease in Switzerland is discussed, also in the context of lung adenomatosis.
  • [MeSH-major] Adenocarcinoma / veterinary. Jaagsiekte sheep retrovirus / isolation & purification. Nose Neoplasms / veterinary. Pulmonary Adenomatosis, Ovine / diagnosis. Sheep Diseases / diagnosis

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  • (PMID = 18605021.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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64. Langers AM, De Vos tot Nederveen Cappel WH, Veenendaal RA, Bonsing BA, Hardwick JC, Vasen HF: Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple. Endoscopy; 2008 Sep;40(9):773-4
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  • [Title] Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple.
  • Patients with familial adenomatous polyposis (FAP) have a 5%-10% lifetime risk of developing duodenal cancer.
  • In severe duodenal polyposis, pancreaticoduodenectomy according to Whipple has been considered the only way to cure duodenal polyposis.
  • However, polyps recur even after surgery.
  • We describe a patient with severe adenomatosis of the small bowel in the afferent loop of a Roux-en-Y anastomosis after a Whipple procedure, detected by double balloon endoscopy (DBE).
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Adenomatous Polyposis Coli / complications. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / surgery. Endoscopy / methods
  • [MeSH-minor] Anastomosis, Roux-en-Y. Catheterization. Cholangiopancreatography, Endoscopic Retrograde. Duodenal Diseases / surgery. Duodenoscopy. Humans. Intestinal Polyps / surgery. Male. Middle Aged. Pancreaticoduodenectomy. Polyps / surgery. Recurrence


65. Gallagher MC, Phillips RK, Bulow S: Surveillance and management of upper gastrointestinal disease in Familial Adenomatous Polyposis. Fam Cancer; 2006;5(3):263-73
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  • [Title] Surveillance and management of upper gastrointestinal disease in Familial Adenomatous Polyposis.
  • Almost all patients affected by Familial Adenomatous polyposis (FAP) will develop foregut as well as hindgut polyps, and following prophylactic colectomy duodenal cancer constitutes one of the leading causes of death in screened populations.
  • Management of the upper gastrointestinal cancer risk is one of the greatest challenges facing clinicians involved in the care of Polyposis families, and with improved survival following prophylactic colectomy, the burden of foregut disease (particularly duodenal adenomatosis) will increase.
  • Until recently, the value of upper gastrointestinal surveillance in FAP populations has been contentious, but with improved understanding of the natural history coupled with developments in surgery, interventional endoscopy and medical therapy, treatment algorithms for duodenal adenomatosis in FAP are becoming clearer.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Neoplasms / therapy. Upper Gastrointestinal Tract / pathology

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  • (PMID = 16998672.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 126
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66. Jeannot E, Poussin K, Chiche L, Bacq Y, Sturm N, Scoazec JY, Buffet C, Van Nhieu JT, Bellanné-Chantelot C, de Toma C, Laurent-Puig P, Bioulac-Sage P, Zucman-Rossi J: Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. Cancer Res; 2007 Mar 15;67(6):2611-6
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  • In rare cases, HNF1alpha germ line mutations could also predispose to familial adenomatosis.
  • In addition, an E229K CYP1B1 mutation was found in a woman with a germ line HNF1alpha mutation in a familial adenomatosis context.
  • In this large family, all three patients with adenomatosis bore both HNF1 and CYP1B1 germ line mutations.
  • [MeSH-minor] Adolescent. Adult. Alleles. Aryl Hydrocarbon Hydroxylases. Child. Cytochrome P-450 CYP1B1. Female. Genetic Predisposition to Disease. Genotype. Humans. Middle Aged. Mutagenesis, Site-Directed. Pedigree

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  • (PMID = 17363580.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hepatocyte Nuclear Factor 1-alpha; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / CYP1B1 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP1B1
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67. Gorbacheva OS, Popova LP, Ivanov SV, Iakovleva MV, Bondarev VP: [Cytological classification of nontoxic nodular goiter]. Klin Lab Diagn; 2008 Jan;(1):37-9

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  • By comparing the cytological and histological data on thyroid nodular lesions in 715 patients, the authors have arrived at the conclusion that with a cytological response of colloidal goiter and colloidal goiter with adenomatosis, the cancer detection rate is not greater than 4%.
  • With a cytological response of adenomatosis with atypia and follicular tumor, a malignancy occurs in 9 to 13%.
  • It is recommended that cytological data should be grouped by the type of a morphological classification of thyroid nodular diseases: colloidal goiter (with regression, proliferation, adenomatosis, cystic cavity); tumors (adenomatosis with atypia, follicular tumor); cancer.

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  • (PMID = 18320618.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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68. Astakhova TM, Delone GV, Lyupina YV, Abramova EB, Uryvaeva IV, Sharova NP: Changes in the Proteasome Pool during Malignant Transformation of Mouse Liver Cells. Acta Naturae; 2010 Apr;2(1):102-8

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  • Multiple forms of proteasomes regulate cellular processes by destroying proteins or forming the peptides involved in those processes.
  • Our results indicate that nodular regenerative hyperplasia and adenomatosis may be stages preceding carcinogenesis.

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  • (PMID = 22649635.001).
  • [ISSN] 2075-8251
  • [Journal-full-title] Acta naturae
  • [ISO-abbreviation] Acta Naturae
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Russia (Federation)
  • [Other-IDs] NLM/ PMC3347545
  • [Keywords] NOTNLM ; 19S proteasome activator / Western blot analysis / adenoma / chymotrypsin–like activity of proteasomes / hepatocellular carcinoma / immunoproteasomes / mouse liver / nodular regenerative hyperplasia of the liver
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69. Entz-Werlé N, Choquet P, Neuville A, Kuchler-Bopp S, Clauss F, Danse JM, Simo-Noumbissie P, Guérin E, Gaub MP, Freund JN, Boehm N, Constantinesco A, Lutz P, Guenot D, Perrin-Schmitt F: Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease. Transl Oncol; 2010;3(6):344-53
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  • TWIST and adenomatosis polyposis coli (APC) are critical signaling factors in normal bone development.

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  • (PMID = 21151473.001).
  • [ISSN] 1936-5233
  • [Journal-full-title] Translational oncology
  • [ISO-abbreviation] Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3000459
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70. Radford IR, Lobachevsky PN: Clustered DNA lesion sites as a source of mutations during human colorectal tumourigenesis. Mutat Res; 2008 Nov 10;646(1-2):60-8
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  • We used statistical analyses to search for sets of dinucleotide sequences (designated target sequences) that are present at and in close proximity to mutation sites in four genes associated with human colorectal tumourigenesis (adenomatosis polyposis coli (APC), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA), and tumour protein p53 (TP53)).
  • Our results strongly suggest a statistical association between the presence of multiple, clustered target sequences and mutational events.

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  • (PMID = 18824008.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 9007-49-2 / DNA; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human
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71. Bülow S, Bülow C, Vasen H, Järvinen H, Björk J, Christensen IJ: Colectomy and ileorectal anastomosis is still an option for selected patients with familial adenomatous polyposis. Dis Colon Rectum; 2008 Sep;51(9):1318-23
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  • [Title] Colectomy and ileorectal anastomosis is still an option for selected patients with familial adenomatous polyposis.
  • PURPOSE: The risk of rectal cancer after colectomy and ileorectal anastomosis may be reduced in the last decades, as patients with severe polyposis now have an ileoanal pouch.
  • This indicates that ileorectal anastomosis may still be justified in selected patients with mild adenomatosis, especially in young females.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Colectomy. Ileum / surgery. Rectal Neoplasms / epidemiology. Rectum / surgery

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  • (PMID = 18523824.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Kámory E, Olasz J, Csuka O: Somatic APC inactivation mechanisms in sporadic colorectal cancer cases in Hungary. Pathol Oncol Res; 2008 Mar;14(1):51-6
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  • The role of germline inactivation of the adenomatosis polyposis coli (APC) gene in hereditary colorectal cancer is well known, being the most important cause of familial adenomatosus polyposis (FAP) syndrome.

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  • (PMID = 18369740.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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73. Flemming P, Lehmann U, Steinemann D, Kreipe H, Wilkens L: [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma]. Pathologe; 2006 Jul;27(4):238-43
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  • A limitation of particular HCA in genetic and metabolic diseases, children, adult males, adenomatosis, and HCA-like tumors with known risk factors of HCC would seem pragmatically meaningful.

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  • (PMID = 16736176.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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74. Rosoff PM, Larrier N, Rice HE: Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease. Pediatr Blood Cancer; 2005 Oct 15;45(5):728-31
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  • The tumor did not occur at either a surgical site or within a radiation field.
  • She did not carry a mutation for familial adenomatosis polypoli.

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  • (PMID = 16035093.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Lejeune S, Guillemot F, Triboulet JP, Cattan S, Mouton C, PAFNORD Group, Porchet N, Manouvrier S, Buisine MP: Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. Hum Mutat; 2006 Oct;27(10):1064

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  • [Title] Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis.
  • Familial adenomatous polyposis has been linked to germline mutations in the APC tumor suppressor gene.
  • However, a number of patients with familial adenomatous polyposis (with either classical or attenuated phenotype) have no APC mutation.
  • Moreover, biallelic mutations in the base excision repair gene MUTYH have been associated with polyposis and early-onset colorectal cancer.
  • AXIN2 and MUTYH genes were screened for germline mutations by PCR and direct sequencing in 39 unrelated patients with multiple adenomas or colorectal cancer without evidence of APC mutation nor mismatch repair defect.
  • Two novel AXIN2 variants were detected in one patient with multiple adenomas, but no clearly pathogenic mutation.
  • Biallelic MUTYH mutations were only found in patients with multiple adenomatous polyposis (7 out of 22 (32%)).
  • Moreover, one patient with biallelic MUTYH mutations presented with multiple adenomas and severe tooth agenesis.
  • Therefore, germline mutations are rare in AXIN2 but frequent in MUTYH in patients with multiple adenomas.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Cytoskeletal Proteins / genetics. DNA Glycosylases / genetics. Mutation / genetics

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  • (PMID = 16941501.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AXIN2 protein, human; 0 / Axin Protein; 0 / Cytoskeletal Proteins; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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76. Björklund P, Akerström G, Westin G: Accumulation of nonphosphorylated beta-catenin and c-myc in primary and uremic secondary hyperparathyroid tumors. J Clin Endocrinol Metab; 2007 Jan;92(1):338-44
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  • In renal failure, secondary hyperparathyroidism (sHPT) occurs with multiple tumor development as a result of calcium and vitamin D regulatory disturbance.
  • No mutation was detected in secondary hyperplastic glands (n = 20), and no evidence for truncated adenomatosis polyposis coli proteins was found in adenomas and secondary hyperplastic glands.

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  • (PMID = 17047023.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-myc; 0 / Wnt Proteins; 0 / beta Catenin
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77. Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R: Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology; 2009;41(4):372-8
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  • Unusual architectural patterns resembled breast lesions such as erosive adenomatosis, sclerosing adenosis and ductal adenoma.
  • The ductal cell and a site compatible with and/or the presence of adjacent normal MLG are the most characteristic features.
  • Unusual vulvar tumours, which have been previously reported as erosive adenomatosis, sclerosing adenosis, papillary adenofibroma, syringocystadenoma papilliferans, etc., are variants of MLG adenomas.

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  • (PMID = 19404851.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 46
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78. Oyama T, Yamada Y, Hata K, Tomita H, Hirata A, Sheng H, Hara A, Aoki H, Kunisada T, Yamashita S, Mori H: Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice. Carcinogenesis; 2008 Mar;29(3):666-72
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  • Apc(Min/+) mouse, a mouse model for human familial adenomatosis polyposis, contains a truncating mutation in the Apc gene and spontaneously develops intestinal tumors.

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  • (PMID = 18204079.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dkk1 protein, mouse; 0 / Intercellular Signaling Peptides and Proteins; 0 / T Cell Transcription Factor 1; 0 / Wnt Proteins; 0 / beta Catenin
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79. Ghosh N, Chaki R, Mandal V, Mandal SC: COX-2 as a target for cancer chemotherapy. Pharmacol Rep; 2010 Mar-Apr;62(2):233-44
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  • Moreover, clinical trials in patients with familial adenomatosis polyposis syndrome have shown the efficacy of selective COX-2 inhibitors in the reduction of the number and size of colorectal polyps.

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  • (PMID = 20508278.001).
  • [ISSN] 1734-1140
  • [Journal-full-title] Pharmacological reports : PR
  • [ISO-abbreviation] Pharmacol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.2 / pyruvate dehydrogenase (acetyl-transferring) kinase; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases; JCX84Q7J1L / Celecoxib
  • [Number-of-references] 72
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80. Matsumoto T, Esaki M, Yanaru-Fujisawa R, Moriyama T, Yada S, Nakamura S, Yao T, Iida M: Small-intestinal involvement in familial adenomatous polyposis: evaluation by double-balloon endoscopy and intraoperative enteroscopy. Gastrointest Endosc; 2008 Nov;68(5):911-9
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  • [Title] Small-intestinal involvement in familial adenomatous polyposis: evaluation by double-balloon endoscopy and intraoperative enteroscopy.
  • BACKGROUND: Small-intestinal adenoma occurs in patients with familial adenomatous polyposis (FAP).
  • Phenotypes of FAP and genotypes of adenomatous polyposis coli (APC) were then compared between patients with small-intestinal adenomas and those without.
  • The adenomas occurred predominantly in the jejunum, with a configuration of diminutive polyps in 22 patients.
  • Patients with small-intestinal adenoma had more severe duodenal adenomatosis than those patients without small-intestinal adenoma (P < .001).
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Duodenal Neoplasms / pathology. Endoscopy, Gastrointestinal. Jejunal Neoplasms / pathology


81. Siderits R, Hanna I, Baig Z, Godyn JJ: Sporadic ganglioneuromatosis of esophagogastric junction in a patient with gastro-esophageal reflux disorder and intestinal metaplasia. World J Gastroenterol; 2006 Dec 28;12(48):7874-7
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  • Biopsies showed prominent intestinal metaplasia of Barrett's type without dysplasia, chronic inflammation and multiple aggregates of large cells within the mucosal lamina propria, some with spindle shaped nuclei.
  • No genetic syndromes were identified in the patient including familial adenomatous polyposis and multiple endocrine neoplasia type IIb (MEN IIb).

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  • [Cites] Hum Pathol. 1999 Oct;30(10):1213-20 [10534170.001]
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  • (PMID = 17203537.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087559
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82. Grazioli L, Bondioni MP, Faccioli N, Gambarini S, Tinti R, Schneider G, Kirchin M: Solid focal liver lesions: dynamic and late enhancement patterns with the dual phase contrast agent gadobenate dimeglumine. J Gastrointest Cancer; 2010 Dec;41(4):221-32
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  • IMAGING FINDINGS: Unenhanced T2- and T1-weighted, dynamic T1-weighted (arterial, portal-venous, and equilibrium) and late phase (1-3 h) Gd-BOPTA-enhanced MR imaging of different focal liver lesions (nodular regenerative hyperplasia, hepatic adenoma, liver adenomatosis, hepatocellular carcinoma, peripheral cholangiocarcinoma, hypervascular metastases, and hypovascular metastases) are shown.

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  • (PMID = 20405242.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 15G12L5X8K / gadobenic acid; 6HG8UB2MUY / Meglumine
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83. de Ferro SM, Suspiro A, Fidalgo P, Lage P, Rodrigues P, Fragoso S, Vitoriano I, Baltazar C, Albuquerque C, Bettencourt A, Leitão CN: Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case. Dis Colon Rectum; 2009 Apr;52(4):742-5
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  • [Title] Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case.
  • MYH-associated polyposis is an inherited autosomal recessive disease, linked to biallelic germline MYH mutations, which predisposes to the development of multiple colorectal adenomas and cancer.
  • We report the case of a young male patient with an aggressive MYH-associated polyposis phenotype.
  • He presented at aged 30 years with more than 100 colonic polyps and 4 colonic adenocarcinomas.
  • At aged 35 years, Spigelman Stage IV duodenal adenomatosis was detected.
  • Based on this report, we believe that screening of the entire small bowel should be recommended in MYH-associated polyposis patients, especially in those with duodenal adenomas.
  • Similar to patients with familial adenomatous polyposis, desmoid tumors also may be part of the clinical spectrum of MYH-associated polyposis and may prove to be a significant clinical problem in patients submitted to prophylactic colectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. Fibromatosis, Aggressive / genetics. Jejunal Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Peritoneal Neoplasms / genetics

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  • (PMID = 19404084.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases
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84. Kadzhaia NR, Virsaladze DK, Tkeshelashvili BD, Dzhavashvili LV, Dzhugeli MK: [Endocrine-metabolic peculiarities in women of reproductive age with hyperplastic processes of cervix and mammary glands]. Georgian Med News; 2006 May;(134):60-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 72 patients with hyperplastic processes in endomyometrium, uterine cervix (hyperplasia, polyposis, myoma) and mammary glands (fibroadenomatosis, adenomatosis) were selected in main group.


85. Bechmann LP, Hilgard P, Frilling A, Schumacher B, Baba HA, Gerken G, Zoepf T: Successful photodynamic therapy for biliary papillomatosis: a case report. World J Gastroenterol; 2008 Jul 14;14(26):4234-7
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  • After drainage of the left hepatic duct with a percutaneous transhepatic cholangial drainage (PTCD) catheter, a recurrent biliary adenomatosis was diagnosed by cholangioscopy.
  • Three mo after he received further photodynamic therapies, the bile duct epithelium appeared normal and the patient had no signs of adenomatosis, both macroscopically and histologically.

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  • (PMID = 18636672.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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86. Bisceglia M, Gatta A, Tomezzoli A, Donataccio M: Multiple spontaneous liver cell adenomas of different types (liver adenomatosis). Adv Anat Pathol; 2009 May;16(3):172-9
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  • [Title] Multiple spontaneous liver cell adenomas of different types (liver adenomatosis).
  • Notwithstanding the nosologic advancement, and outside the "archetypal" types, the differential morphologic diagnosis of spontaneous HCA versus FNH may remain problematic as ductular proliferation in some cases of FNH may be scanty and hard to find.
  • In some histologic overlapping cases of FNH and HCA the morphologic diagnosis may be very difficult or even impossible (especially in small lesions) and molecular biology may be of critical assistance.
  • A prototypical case of surgically resected multiple spontaneous liver cell adenomas of various types, including HCA of T-FNH type and steatotic type, previously interpreted in different ways, affecting a young girl, is presented herein.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19395881.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Bioulac-Sage P, Laumonier H, Laurent C, Zucman-Rossi J, Balabaud C: Hepatocellular adenoma: what is new in 2008. Hepatol Int; 2008 Sep;2(3):316-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomatosis is frequently detected in this context.

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  • (PMID = 19669260.001).
  • [ISSN] 1936-0533
  • [Journal-full-title] Hepatology international
  • [ISO-abbreviation] Hepatol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2716879
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88. Bliznashki I, Minev M, Mikhova A, Velev M: [A rare case of Gardner's syndrome complicated with rectal carcinoma]. Khirurgiia (Sofiia); 2007;(3):60-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gardner's syndrome is a rare variant of the Familial Adenomatous Polyposis (FAP) in which affected individuals develop thousands of polyps within the gastrointestinal tract, with a 100 % risk of eventual malignant change.
  • Gardner's syndrome is an autosomal dominant disease, caused by mutations in APC ( adenomatous polyposis coli ) gene, which is located in chromosomal locus 5q21- q22.
  • They have investigated a family of 51 members with polyposis, some of them with multiple epidermoid cysts, fibromas and jaw osteomas.
  • He had multiple adenomatous polyposis of colon, rectal cancer, osteomas of skull bones, subcutaneous fibromas and lipomas.
  • We discovered also by ultrasound examination a polyp of gall bladder.
  • His father has had also multiple polyposis with malignancy and metastatic lesions and he has died at age of 49 years.
  • [MeSH-minor] Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli / surgery. Adult. Cholecystectomy. Epidermal Cyst / diagnosis. Epidermal Cyst / genetics. Epidermal Cyst / surgery. Humans. Male. Osteoma / diagnosis. Osteoma / genetics. Osteoma / surgery. Proctocolectomy, Restorative

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  • (PMID = 18437113.001).
  • [ISSN] 0450-2167
  • [Journal-full-title] Khirurgii︠a︡
  • [ISO-abbreviation] Khirurgiia (Sofiia)
  • [Language] bul
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Bulgaria
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89. Kemp ZE, Carvajal-Carmona LG, Barclay E, Gorman M, Martin L, Wood W, Rowan A, Donohue C, Spain S, Jaeger E, Evans DG, Maher ER, Bishop T, Thomas H, Houlston R, Tomlinson I, Colorectal Tumour Gene Identification Study Consortium: Evidence of linkage to chromosome 9q22.33 in colorectal cancer kindreds from the United Kingdom. Cancer Res; 2006 May 15;66(10):5003-6
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  • Exclusion from the analysis of kindreds with a phenotype of multiple polyposis also found evidence of linkage in the same region (NPL = 2.47 at close to D9S277, P = 0.009).

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  • (PMID = 16707420.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Vermeil V, D'Amore L, Ceci F, Dassatti MR, Negro A, Gossetti F, Negro P: [Familial polyposis coli associated with carcinoma of the uterine cervix]. Chir Ital; 2008 May-Jun;60(3):355-9
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  • [Title] [Familial polyposis coli associated with carcinoma of the uterine cervix].
  • Familial polyposis coli is a heterogeneous disease with a broad spectrum of clinical manifestations including not only multiple polyposis of the small bowel, but also multiple primary tumours, such as carcinoma of the ampulla of Vater, subcutaneous tumours, bone tumours, central nervous system tumous and gynaecological malignancies.
  • This report is of two brothers with familial polyposis, each showing peculiar distinctive features.
  • In one case, polyposis was diagnosed during emergency surgery for ileo-colic intussusception.
  • Polyposis coli was identified late in the second patient who showed an evolution towards colonic adenocarcinoma with multiple hepatic metastases.
  • The possible association of familial polyposis and extracolonic malignancies has already been emphasized in the literature.
  • [MeSH-major] Adenomatous Polyposis Coli. Carcinoma in Situ. Neoplasms, Multiple Primary. Uterine Cervical Neoplasms

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  • (PMID = 18709773.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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91. Raphe R, Felício HC, Rocha MF, Duca WJ, Arroyo PC Jr, D'Santi Neto D, da Silva RC, da Silva RF: Histopathologic characteristics of incidental hepatocellular carcinoma after liver transplantation. Transplant Proc; 2010 Mar;42(2):505-6
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  • One patient presented with adenomatosis and focus of HCC.

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20304178.001).
  • [ISSN] 1873-2623
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
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92. Miller MJ, Reuter BK, Wallace JL, Sharkey KA: A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. J Transl Med; 2008;6:3
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  • In the ApcMinmouse model of precancerous adenomatosis polyposis, mice received Zangrado (100 mug/ml in drinking water) from the age of 6 - 16 weeks for effects on polyp number.

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  • (PMID = 18205911.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AM 251; 0 / Antiemetics; 0 / Antipruritics; 0 / Morphine Derivatives; 0 / Piperidines; 0 / Plant Extracts; 0 / Proanthocyanidins; 0 / Pyrazoles; 0 / Receptor, Cannabinoid, CB1; 18206-61-6 / proanthocyanidin; 20290-10-2 / morphine-6-glucuronide
  • [Other-IDs] NLM/ PMC2254379
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93. Xue Y, Johnson R, Desmet M, Snyder PW, Fleet JC: Generation of a transgenic mouse for colorectal cancer research with intestinal cre expression limited to the large intestine. Mol Cancer Res; 2010 Aug;8(8):1095-104
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  • Genetically modified mice have been used for colon cancer research, but findings from these models are confounded by expression of cancer in multiple organs.
  • We sought to create a transgenic mouse with Cre recombinase (Cre) expression limited to the epithelial cells of the large intestine and used this model to study colon cancer driven by adenomatosis polyposis coli (APC) gene inactivation.
  • By 10 weeks, 20% of CAC;APC(580S/+) mice developed adenomatous lesions in the distal colon (3.0 +/- 0.4 mm; 1.1 per mouse).


94. Kogan EA, Tyong FV, Demura SA: [The mechanism of lung tissue remodeling in the progression of idiopathic pulmonary fibrosis]. Arkh Patol; 2010 Jul-Aug;72(4):30-6
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  • Thus, lung tissue remodeling in the progression of IPF from the early to late stage of the disease comprises interrelated processes that are largely localized in the BATZ, such as immune inflammation with pathological reparation, neoangiogenesis, apoptosis, and proliferation of epitheliocytes and myofibroblasts, which lead to the development of interstitial fibrosis and adenomatosis of the lung.


95. Poomthavorn P, Wong SH, Higgins S, Werther GA, Russo VC: Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells. Endocr Relat Cancer; 2009 Sep;16(3):991-1004
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  • In hypoxic SH-SY5Y NB cells, real-time PCR analysis showed that the genes involved in maintenance of cell-cell and cell-matrix interactions (i.e. adenomatosis polyposis coli, E-cadherin, catenin, EphB2, fibronectin-1, HTATIP2, tissue inhibitor of metalloprotease-4) were down-regulated by up to 90%, while genes involved in enhancement of metastatic behavior (integrin a7b1, hepatocyte growth factor receptor, transforming growth factor-beta1, VEGF, kisspeptin, interleukin-1beta) were dramatically up-regulated above 200%.

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  • (PMID = 19423615.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimutagenic Agents; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / ID1 protein, human; 0 / ID2 protein, human; 0 / Inhibitor of Differentiation Protein 1; 0 / Inhibitor of Differentiation Protein 2; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 3G0H8C9362 / Cobalt; EVS87XF13W / cobaltous chloride
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96. Amemori H, Hyakutake M, Maeda Y, Tomita Y, Mitsumizo S, Oishi H, Koizumi S, Nakashima M, Araki K: Survival case of Vibrio vulnificus infection with multiple endocrine neoplasia type I. Fukuoka Igaku Zasshi; 2007 Sep;98(9):346-52
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  • [Title] Survival case of Vibrio vulnificus infection with multiple endocrine neoplasia type I.
  • A 35-year-old female with malabsorption syndrome who underwent a pancreatoduodenectomy for multiple endocrine adenomatosis 13 years prior was admitted to our hospital with diarrhea, general fatigue, high fever, and eruption in the lower legs.
  • [MeSH-major] Immunocompromised Host. Multiple Endocrine Neoplasia Type 1 / complications. Vibrio Infections / etiology. Vibrio Infections / therapy. Vibrio vulnificus

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  • (PMID = 17974078.001).
  • [ISSN] 0016-254X
  • [Journal-full-title] Fukuoka igaku zasshi = Hukuoka acta medica
  • [ISO-abbreviation] Fukuoka Igaku Zasshi
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Catecholamines; 9M416Z9QNR / Ceftazidime; FYY3R43WGO / Minocycline; IY9XDZ35W2 / Glucose
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97. Steinemann D, Skawran B, Becker T, Tauscher M, Weigmann A, Wingen L, Tauscher S, Hinrichsen T, Hertz S, Flemming P, Flik J, Wiese B, Kreipe H, Lichter P, Schlegelberger B, Wilkens L: Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization. Clin Gastroenterol Hepatol; 2006 Oct;4(10):1283-91
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  • However, in 2 adenomas with a known history of glycogenosis type I and adenomatosis hepatis gains of 1q were found, too.

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  • (PMID = 16979954.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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98. Méric JB, Rottey S, Olaussen K, Soria JC, Khayat D, Rixe O, Spano JP: Cyclooxygenase-2 as a target for anticancer drug development. Crit Rev Oncol Hematol; 2006 Jul;59(1):51-64
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  • Moreover, clinical trials in patients with familial adenomatosis polyposis syndrome have shown too the efficacy of non-selective COX inhibitors and recently also of selective COX-2 inhibitors in the reduction of the number and the size of colorectal polyps.

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  • (PMID = 16531064.001).
  • [ISSN] 1040-8428
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; EC 1.14.99.1 / Cyclooxygenase 2
  • [Number-of-references] 130
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99. Ivanov SV, Zhabin SN, Gorbacheva OS, Barsukov VS, Denisova EIu: [Multifactor analysis of nodular goiter by the method of artificial neural network]. Klin Med (Mosk); 2008;86(4):49-50

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  • Study of 297 patients with preparative methods of nontoxic nodular goiter and cytological diagnose "adenomatosis" with the use of artificial neural network (ANN) were analyzed.
  • Painless elastic nodules with sonographically iso- o hyperechogenic structure, with clear outline and cytologically determined adenomatosis in combination with colloid can be interpreted as benign lesion of thyroid gland.

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  • (PMID = 18494287.001).
  • [ISSN] 0023-2149
  • [Journal-full-title] Klinicheskaia meditsina
  • [ISO-abbreviation] Klin Med (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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100. Hardy OT, Hernandez-Pampaloni M, Saffer JR, Scheuermann JS, Ernst LM, Freifelder R, Zhuang H, MacMullen C, Becker S, Adzick NS, Divgi C, Alavi A, Stanley CA: Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism. J Clin Endocrinol Metab; 2007 Dec;92(12):4706-11
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  • OBJECTIVES: Focal lesions in infants with congenital hyperinsulinism (HI) represent areas of adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation due to embryonic loss of heterozygosity for the maternal 11p region.
  • The positive predictive value of [18F]DOPA in diagnosing focal adenomatosis was 100%, and the negative predictive value was 81%.
  • These results suggest that [18F]DOPA PET imaging provides a useful guide to surgical resection of focal adenomatosis and should be considered as a guide to surgery in all infants with congenital HI who have medically uncontrollable disease.
  • [MeSH-minor] Biopsy. Humans. Image Interpretation, Computer-Assisted. Infant. Infant, Newborn. Islets of Langerhans / pathology. Kidney / pathology. Multiple Endocrine Neoplasia / pathology. Multiple Endocrine Neoplasia / radionuclide imaging. Pancreatectomy. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography. Sample Size

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  • (PMID = 17895314.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR-00240; United States / NIDDK NIH HHS / DK / R01-DK-56268; United States / NIDDK NIH HHS / DK / T32-DK63688
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 2C598205QX / fluorodopa F 18; 63-84-3 / Dihydroxyphenylalanine
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