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Items 1 to 48 of about 48
1. Kycko A, Reichert M: [Current views on the mechanism of oncogenic cell transformation in ovine pulmonary adenocarcinoma]. Postepy Hig Med Dosw (Online); 2007 Dec 10;61:797-804
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  • [Title] [Current views on the mechanism of oncogenic cell transformation in ovine pulmonary adenocarcinoma].
  • Bronchioloalveolar cancer, which is a subtype of the most common primary lung cancer, adenocarcinoma, is very similar to ovine pulmonary adenocarcinoma (OPA), a naturally occurring lung cancer in sheep.

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  • (PMID = 18097338.001).
  • [ISSN] 1732-2693
  • [Journal-full-title] Postepy higieny i medycyny doswiadczalnej (Online)
  • [ISO-abbreviation] Postepy Hig Med Dosw (Online)
  • [Language] POL
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] EC 2.7.7.49 / Telomerase
  • [Number-of-references] 55
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2. Caporale M, Centorame P, Giovannini A, Sacchini F, Di Ventura M, De las Heras M, Palmarini M: Infection of lung epithelial cells and induction of pulmonary adenocarcinoma is not the most common outcome of naturally occurring JSRV infection during the commercial lifespan of sheep. Virology; 2005 Jul 20;338(1):144-53
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  • [Title] Infection of lung epithelial cells and induction of pulmonary adenocarcinoma is not the most common outcome of naturally occurring JSRV infection during the commercial lifespan of sheep.
  • Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA).
  • We established groups derived from flocks with either a high or low incidence of OPA and monitored virus transmission, clinical disease and macroscopic/microscopic lung lesions at necropsy.
  • (ii) only a minority of JSRV-infected animals develop clinical disease during their commercial lifespan; and (iii) JSRV is more readily detectable in peripheral blood leucocytes and lymphoid organs than in the lungs.
  • [MeSH-major] Adenocarcinoma / veterinary. Jaagsiekte sheep retrovirus / pathogenicity. Lung Neoplasms / veterinary. Pulmonary Adenomatosis, Ovine / etiology. Sheep Diseases / etiology

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  • (PMID = 15950254.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA95706-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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3. Kaufmann C, Brechbühl M, Oevermann A, Müller S, Zimmer K, Schönmann M, Leroux C, Weibel D, Bertoni G: [Enzootic nasal adenocarcinoma in a dairy sheep flock]. Schweiz Arch Tierheilkd; 2008 Jun;150(6):297-302
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  • The significance of the disease in Switzerland is discussed, also in the context of lung adenomatosis.
  • [MeSH-major] Adenocarcinoma / veterinary. Jaagsiekte sheep retrovirus / isolation & purification. Nose Neoplasms / veterinary. Pulmonary Adenomatosis, Ovine / diagnosis. Sheep Diseases / diagnosis

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  • (PMID = 18605021.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
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4. Yoo SB, Chung JH, Lee HJ, Lee CT, Jheon S, Sung SW: Epidermal growth factor receptor mutation and p53 overexpression during the multistage progression of small adenocarcinoma of the lung. J Thorac Oncol; 2010 Jul;5(7):964-9
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  • We examined the mutation of the epidermal growth factor receptor (EGFR) gene and p53 protein overexpression in the AAH, BAC, and small ADC to understand their role in the pulmonary ADC pathogenesis.
  • CONCLUSIONS: High frequency and similar incidence of EGFR mutation in AAH, BAC, and ADC support that EGFR gene mutation occurs in the early stage of pulmonary ADC development and tumor initiation from the preneoplastic lung parenchyma to neoplastic conditions.
  • On the contrary, p53 overexpression is a late event during tumor development and plays a role in the progression of the peripheral pulmonary ADC.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / genetics. Adenocarcinoma, Bronchiolo-Alveolar / metabolism. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenomatosis, Pulmonary / genetics. Adenomatosis, Pulmonary / metabolism. Adenomatosis, Pulmonary / pathology. Adult. Aged. Aged, 80 and over. Disease Progression. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Polymerase Chain Reaction. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Prognosis

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  • (PMID = 20512074.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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5. Beytut E, Sözmen M, Ergínsoy S: Immunohistochemical detection of pulmonary surfactant proteins and retroviral antigens in the lungs of sheep with pulmonary adenomatosis. J Comp Pathol; 2009 Jan;140(1):43-53
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  • [Title] Immunohistochemical detection of pulmonary surfactant proteins and retroviral antigens in the lungs of sheep with pulmonary adenomatosis.
  • The lungs and mediastinal and bronchial lymph nodes from 26 sheep with ovine pulmonary adenomatosis (OPA) were examined.
  • The neoplastic cells had more diffuse and intense expression of pulmonary surfactant protein-A (SP-A) compared with the expression of SP-B or SP-C.
  • CD3(+) T lymphocytes infiltrated the pulmonary tissue and surrounded the neoplastic foci.
  • The results of this study demonstrate that JSRV continues to replicate in neoplastic cells after they have been transformed, and that the neoplastic cells produce pulmonary surfactant proteins.
  • [MeSH-major] Antigens, Viral / metabolism. Lung / metabolism. Pulmonary Adenomatosis, Ovine / metabolism. Pulmonary Surfactant-Associated Protein A / metabolism. Pulmonary Surfactant-Associated Protein B / metabolism. Pulmonary Surfactant-Associated Protein C / metabolism. Retroviridae / immunology

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  • (PMID = 19081577.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, Viral; 0 / Proliferating Cell Nuclear Antigen; 0 / Pulmonary Surfactant-Associated Protein A; 0 / Pulmonary Surfactant-Associated Protein B; 0 / Pulmonary Surfactant-Associated Protein C; 9060-09-7 / Uteroglobin
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6. Suau F, Cottin V, Archer F, Croze S, Chastang J, Cordier G, Thivolet-Béjui F, Mornex JF, Leroux C: Telomerase activation in a model of lung adenocarcinoma. Eur Respir J; 2006 Jun;27(6):1175-82
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  • Ovine pulmonary adenocarcinoma (OPA) is a lung cancer strikingly similar to the pneumonic-type mixed invasive adenocarcinoma with a predominant bronchioloalveolar component in humans.
  • Telomerase activation takes place in ovine pulmonary adenocarcinoma tumour cells and may be partly attributable to Akt activation.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma, Bronchiolo-Alveolar / genetics. Disease Models, Animal. Jaagsiekte sheep retrovirus / genetics. Lung Neoplasms / genetics. Pulmonary Adenomatosis, Ovine / genetics. Telomerase / genetics
  • [MeSH-minor] Animals. Cell Aging / genetics. Cell Division / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Enzyme Activation / genetics. Gene Expression Regulation / genetics. Humans. Lung / pathology. Proto-Oncogene Proteins c-akt / genetics. Pulmonary Alveoli / pathology. Sheep. Signal Transduction / genetics. Tumor Cells, Cultured / pathology

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  • [CommentIn] Eur Respir J. 2006 Jun;27(6):1079-81 [16772385.001]
  • (PMID = 16455826.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.7.49 / Telomerase
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7. Kang MS, Lu H, Yasui T, Sharpe A, Warren H, Cahir-McFarland E, Bronson R, Hung SC, Kieff E: Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. Proc Natl Acad Sci U S A; 2005 Jan 18;102(3):820-5
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  • EBNA1-transgenic lineages had a higher pulmonary adenoma prevalence than did littermate controls (39% versus 7%).
  • However, the adenoma prevalence was not higher in EBNA1-transgenic mice than has been described for FVB mice, and EBNA1 was not expressed in normal pulmonary epithelia or adenomas.

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  • (PMID = 15640350.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA047006; United States / NCI NIH HHS / CA / R35 CA047006; United States / NCI NIH HHS / CA / CA47006
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EBV-encoded nuclear antigen 1; 0 / Epstein-Barr Virus Nuclear Antigens; EC 3.1.3.48 / Antigens, CD45
  • [Other-IDs] NLM/ PMC545574
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8. Leroux C, Girard N, Cottin V, Greenland T, Mornex JF, Archer F: Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep. Vet Res; 2007 Mar-Apr;38(2):211-28
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  • This virus is responsible for a pulmonary adenocarcinoma, by transformation of epithelial cells from the bronchioli and alveoli.
  • [MeSH-major] Jaagsiekte sheep retrovirus / physiology. Lung Neoplasms / veterinary. Pulmonary Adenomatosis, Ovine / virology. Sheep / virology

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  • (PMID = 17257570.001).
  • [ISSN] 0928-4249
  • [Journal-full-title] Veterinary research
  • [ISO-abbreviation] Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 93
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9. Woldemeskel M, Tibbo M: Pulmonary adenomatosis and maedi-visna in Ethiopian central highland sheep: a microscopic study. Trop Anim Health Prod; 2010 Jun;42(5):995-9

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  • [Title] Pulmonary adenomatosis and maedi-visna in Ethiopian central highland sheep: a microscopic study.
  • Lesions compatible with sheep pulmonary adenomatosis (SPA; 8/35, 22.8%), and maedi-visna (MV; 9/35, 25.7%) were recorded only in sheep from the central highlands.
  • [MeSH-major] Pulmonary Adenomatosis, Ovine / epidemiology. Sheep Diseases / epidemiology. Visna / epidemiology. Visna-maedi virus / isolation & purification

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  • (PMID = 20024674.001).
  • [ISSN] 1573-7438
  • [Journal-full-title] Tropical animal health and production
  • [ISO-abbreviation] Trop Anim Health Prod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Luo JR, Liu XH, Yu QY, Zhang SQ, Zhou JH, Ma XE: [A specific PCR assay and a nested PCR assay for the screening of ovine pulmonary adenomatosis]. Bing Du Xue Bao; 2009 Mar;25(2):125-30
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  • [Title] [A specific PCR assay and a nested PCR assay for the screening of ovine pulmonary adenomatosis].
  • Ovine pulmonary adenomatosis (OPA) is a naturally occurring contagious lung tumor of sheep which was caused by an exogenous retrovirus of sheep, jaagsiekte retrovirus (JSRV).
  • The n-PCR was only available in blood test for detection of JSRV infected sheep and might be useful in epidemiological studies and disease control of OPA.

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  • (PMID = 19678567.001).
  • [ISSN] 1000-8721
  • [Journal-full-title] Bing du xue bao = Chinese journal of virology
  • [ISO-abbreviation] Bing Du Xue Bao
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Viral
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11. Voigt K, Krämer U, Brügmann M, Dewar P, Sharp JM, Ganter M: Eradication of ovine pulmonary adenocarcinoma by motherless rearing of lambs. Vet Rec; 2007 Jul 28;161(4):129-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eradication of ovine pulmonary adenocarcinoma by motherless rearing of lambs.
  • The principles of maedi-visna eradication programmes were applied to a field trial for the eradication of ovine pulmonary adenocarcinoma (OPA).
  • [MeSH-major] Animal Husbandry / methods. Jaagsiekte sheep retrovirus / isolation & purification. Pulmonary Adenomatosis, Ovine / prevention & control

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  • (PMID = 17660466.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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12. Griffiths DJ, Martineau HM, Cousens C: Pathology and pathogenesis of ovine pulmonary adenocarcinoma. J Comp Pathol; 2010 May;142(4):260-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathology and pathogenesis of ovine pulmonary adenocarcinoma.
  • Ovine pulmonary adenocarcinoma (OPA), also known as jaagsiekte, is a transmissible lung tumour of sheep caused by jaagsiekte sheep retrovirus (JSRV).
  • In addition to its veterinary importance, OPA is regarded as a potential large animal model for human lung adenocarcinoma and this has stimulated research into the pathogenesis of the ovine disease.
  • This work has produced some significant results, including the finding that one of the JSRV structural proteins is directly involved in oncogenesis.
  • The recent advances in understanding JSRV and the pathogenesis of OPA should lead to novel strategies for diagnosis and control of this disease and for its exploitation as a comparative model for human lung cancer.
  • [MeSH-major] Adenocarcinoma / virology. Jaagsiekte sheep retrovirus / physiology. Pulmonary Adenomatosis, Ovine. Sheep Diseases / virology

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20163805.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 171
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13. Summers C, Norval M, De Las Heras M, Gonzalez L, Sharp JM, Woods GM: An influx of macrophages is the predominant local immune response in ovine pulmonary adenocarcinoma. Vet Immunol Immunopathol; 2005 Jul 15;106(3-4):285-94

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  • [Title] An influx of macrophages is the predominant local immune response in ovine pulmonary adenocarcinoma.
  • Infection with a retrovirus, Jaagsiekte sheep retrovirus (JSRV), causes ovine pulmonary adenocarcinoma (OPA).
  • The excess production of surfactant proteins by alveolar tumour cells results in increased production of pulmonary fluid, which is characteristically expelled through the nostrils of affected sheep.
  • [MeSH-major] Macrophages / immunology. Pulmonary Adenomatosis, Ovine / immunology

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  • (PMID = 15878202.001).
  • [ISSN] 0165-2427
  • [Journal-full-title] Veterinary immunology and immunopathology
  • [ISO-abbreviation] Vet. Immunol. Immunopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD14; 0 / Histocompatibility Antigens Class II; 82115-62-6 / Interferon-gamma
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14. Philbey AW, Cousens C, Bishop JV, Gill CA, DeMartini JC, Sharp JM: Multiclonal pattern of Jaagsiekte sheep retrovirus integration sites in ovine pulmonary adenocarcinoma. Virus Res; 2006 May;117(2):254-63
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  • [Title] Multiclonal pattern of Jaagsiekte sheep retrovirus integration sites in ovine pulmonary adenocarcinoma.
  • Insertional mutagenesis and envelope (Env)-mediated oncogenesis are hypothesized mechanisms by which Jaagsiekte sheep retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA).
  • [MeSH-major] Chromosomes, Mammalian / virology. Jaagsiekte sheep retrovirus / genetics. Pulmonary Adenomatosis, Ovine / virology. Virus Integration / genetics

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  • (PMID = 16310879.001).
  • [ISSN] 0168-1702
  • [Journal-full-title] Virus research
  • [ISO-abbreviation] Virus Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 59116; United States / NCI NIH HHS / CA / CA95706
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins; 9007-49-2 / DNA; EC 3.1.3.48 / PTPRG protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.1.3.48 / Ptprg protein, mouse; EC 3.1.3.48 / Receptor-Like Protein Tyrosine Phosphatases, Class 5
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15. Ohtsuka T, Watanabe K, Kaji M, Naruke T, Suemasu K: A clinicopathological study of resected pulmonary nodules with focal pure ground-glass opacity. Eur J Cardiothorac Surg; 2006 Jul;30(1):160-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathological study of resected pulmonary nodules with focal pure ground-glass opacity.
  • OBJECTIVE: Pulmonary lesions with focal ground-glass opacity (GGO) have been detected increasingly by low-dose helical computed tomography (CT).
  • This study evaluates clinicopathological characteristics of resected pulmonary nodules with focal pure ground-glass opacity.
  • METHODS: Between January 1997 and December 2005, 26 patients (35 lesions) with pure GGO lesions underwent pulmonary resection.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenomatosis, Pulmonary / pathology. Lung Neoplasms / pathology

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  • (PMID = 16723239.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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16. Kogan EA, Tyong FV, Demura SA: [The mechanism of lung tissue remodeling in the progression of idiopathic pulmonary fibrosis]. Arkh Patol; 2010 Jul-Aug;72(4):30-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The mechanism of lung tissue remodeling in the progression of idiopathic pulmonary fibrosis].
  • The aim of the investigation was to study the specific features of morphological manifestations and the molecular bases of lung tissue remodeling in progressive idiopathic pulmonary fibrosis (IPF).
  • In the early stage of the disease, the expression of MMP-1, MMP-2, MMP-7, and TIMP-4 in the epitheliocytes, macrophages, fibroblasts, and myofibroblasts was higher than that in the late stage of IPF.
  • Thus, lung tissue remodeling in the progression of IPF from the early to late stage of the disease comprises interrelated processes that are largely localized in the BATZ, such as immune inflammation with pathological reparation, neoangiogenesis, apoptosis, and proliferation of epitheliocytes and myofibroblasts, which lead to the development of interstitial fibrosis and adenomatosis of the lung.
  • [MeSH-major] Bronchi / metabolism. Bronchi / pathology. Idiopathic Pulmonary Fibrosis / metabolism. Idiopathic Pulmonary Fibrosis / pathology. Pulmonary Alveoli / metabolism. Pulmonary Alveoli / pathology. Respiratory Mucosa / metabolism. Respiratory Mucosa / pathology


17. Voigt K, Brügmann M, Huber K, Dewar P, Cousens C, Hall M, Sharp JM, Ganter M: PCR examination of bronchoalveolar lavage samples is a useful tool in pre-clinical diagnosis of ovine pulmonary adenocarcinoma (Jaagsiekte). Res Vet Sci; 2007 Dec;83(3):419-27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PCR examination of bronchoalveolar lavage samples is a useful tool in pre-clinical diagnosis of ovine pulmonary adenocarcinoma (Jaagsiekte).
  • Ovine pulmonary adenocarcinoma (OPA) is a contagious lung tumour of sheep caused by Jaagsiekte sheep retrovirus (JSRV).
  • The disease is a particular problem in flocks in many parts of the world.
  • [MeSH-major] Bronchoalveolar Lavage Fluid / virology. Jaagsiekte sheep retrovirus / isolation & purification. Polymerase Chain Reaction / veterinary. Pulmonary Adenomatosis, Ovine / diagnosis

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  • (PMID = 17418304.001).
  • [ISSN] 0034-5288
  • [Journal-full-title] Research in veterinary science
  • [ISO-abbreviation] Res. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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18. Archer F, Jacquier E, Lyon M, Chastang J, Cottin V, Mornex JF, Leroux C: Alveolar type II cells isolated from pulmonary adenocarcinoma: a model for JSRV expression in vitro. Am J Respir Cell Mol Biol; 2007 May;36(5):534-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar type II cells isolated from pulmonary adenocarcinoma: a model for JSRV expression in vitro.
  • Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring cancer in sheep, with clinical, radiologic, and histopathologic features similar to that of human pneumonic-type bronchioloalveolar carcinoma.
  • [MeSH-major] Jaagsiekte sheep retrovirus / genetics. Lung Neoplasms / veterinary. Pulmonary Adenomatosis, Ovine / virology. Pulmonary Alveoli / pathology. Pulmonary Alveoli / virology
  • [MeSH-minor] Animals. Biomarkers / metabolism. Cell Aging. Cell Separation. Cells, Cultured. DNA, Viral / analysis. DNA, Viral / genetics. Gene Expression Regulation, Viral. Models, Biological. Pulmonary Surfactant-Associated Protein A / metabolism. Pulmonary Surfactant-Associated Protein C / metabolism. RNA-Directed DNA Polymerase / metabolism. Serial Passage. Sheep, Domestic

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  • (PMID = 17158359.001).
  • [ISSN] 1044-1549
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / DNA, Viral; 0 / Pulmonary Surfactant-Associated Protein A; 0 / Pulmonary Surfactant-Associated Protein C; EC 2.7.7.49 / RNA-Directed DNA Polymerase
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19. Ishikawa H, Koizumi N, Morita T, Tani Y, Tsuchida M, Umezu H, Naito M, Sasai K: Ultrasmall pulmonary opacities on multidetector-row high-resolution computed tomography: a prospective radiologic-pathologic examination. J Comput Assist Tomogr; 2005 Sep-Oct;29(5):621-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasmall pulmonary opacities on multidetector-row high-resolution computed tomography: a prospective radiologic-pathologic examination.
  • OBJECTIVE: To clarify the pathologic findings of ultrasmall pulmonary opacities (5 mm or smaller in diameter) found on multidetector-row high-resolution computed tomography (MD-HRCT).
  • CONCLUSION: Tiny pulmonary lesions, such as AAHs, BACs, and IPLNs, were identified among ultrasmall opacities found on MD-HRCT.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenomatosis, Pulmonary / radiography. Lung Neoplasms / radiography. Precancerous Conditions / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 16163031.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. De Las Heras M, Ortín A, Salvatori D, Pérez de Villareal M, Cousens C, Miguel Ferrer L, Miguel Cebrián L, García de Jalón JA, Gonzalez L, Michael Sharp J: A PCR technique for the detection of Jaagsiekte sheep retrovirus in the blood suitable for the screening of ovine pulmonary adenocarcinoma in field conditions. Res Vet Sci; 2005 Dec;79(3):259-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A PCR technique for the detection of Jaagsiekte sheep retrovirus in the blood suitable for the screening of ovine pulmonary adenocarcinoma in field conditions.
  • Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring contagious lung neoplasia caused by jaagsiekte sheep retrovirus (JSRV).
  • [MeSH-major] Jaagsiekte sheep retrovirus / isolation & purification. Polymerase Chain Reaction / methods. Polymerase Chain Reaction / veterinary. Pulmonary Adenomatosis, Ovine / diagnosis. Pulmonary Adenomatosis, Ovine / virology. Sheep / virology

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  • (PMID = 16054897.001).
  • [ISSN] 0034-5288
  • [Journal-full-title] Research in veterinary science
  • [ISO-abbreviation] Res. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / RNA, Viral
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21. Larruskain A, Minguijón E, García-Etxebarria K, Moreno B, Arostegui I, Juste RA, Jugo BM: MHC class II DRB1 gene polymorphism in the pathogenesis of Maedi-Visna and pulmonary adenocarcinoma viral diseases in sheep. Immunogenetics; 2010 Feb;62(2):75-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MHC class II DRB1 gene polymorphism in the pathogenesis of Maedi-Visna and pulmonary adenocarcinoma viral diseases in sheep.
  • Ovine pulmonary adenocarcinoma (OPA) and Maedi-Visna (Maedi) are two chronic respiratory diseases of retroviral origin which occur worldwide.
  • [MeSH-major] Genes, MHC Class II. Genetic Predisposition to Disease. Pneumonia, Progressive Interstitial, of Sheep / immunology. Pulmonary Adenomatosis, Ovine / immunology

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  • (PMID = 20049428.001).
  • [ISSN] 1432-1211
  • [Journal-full-title] Immunogenetics
  • [ISO-abbreviation] Immunogenetics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Cousens C, Thonur L, Imlach S, Crawford J, Sales J, Griffiths DJ: Jaagsiekte sheep retrovirus is present at high concentration in lung fluid produced by ovine pulmonary adenocarcinoma-affected sheep and can survive for several weeks at ambient temperatures. Res Vet Sci; 2009 Aug;87(1):154-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Jaagsiekte sheep retrovirus is present at high concentration in lung fluid produced by ovine pulmonary adenocarcinoma-affected sheep and can survive for several weeks at ambient temperatures.
  • Jaagsiekte sheep retrovirus (JSRV) causes a fatal lung cancer of sheep known as ovine pulmonary adenocarcinoma (OPA).
  • OPA is a significant disease in many sheep-rearing countries and there is no effective method of control.
  • [MeSH-major] Body Fluids / virology. Jaagsiekte sheep retrovirus / isolation & purification. Jaagsiekte sheep retrovirus / physiology. Lung / virology. Pulmonary Adenomatosis, Ovine / virology

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  • (PMID = 19114283.001).
  • [ISSN] 1532-2661
  • [Journal-full-title] Research in veterinary science
  • [ISO-abbreviation] Res. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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23. McGee-Estrada K, Palmarini M, Hallwirth C, Fan H: A Moloney murine leukemia virus driven by the Jaagsiekte sheep retrovirus enhancers shows enhanced specificity for infectivity in lung epithelial cells. Virus Genes; 2005 Dec;31(3):257-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Jaagsiekte sheep retrovirus (JSRV) is the etiologic agent of ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer in sheep.
  • [MeSH-minor] Animals. Cell Line. Enhancer Elements, Genetic. Epithelial Cells / virology. Genes, Viral. Mice. Plasmids / genetics. Pulmonary Adenomatosis, Ovine / etiology. Pulmonary Adenomatosis, Ovine / virology. Sheep. Terminal Repeat Sequences. Transfection. Virulence / genetics

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  • (PMID = 16175331.001).
  • [ISSN] 0920-8569
  • [Journal-full-title] Virus genes
  • [ISO-abbreviation] Virus Genes
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA85264; United States / NCI NIH HHS / CA / T32 CA09054
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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24. De Las Heras M, Ortín A, Benito A, Summers C, Ferrer LM, Sharp JM: In-situ demonstration of mitogen-activated protein kinase Erk 1/2 signalling pathway in contagious respiratory tumours of sheep and goats. J Comp Pathol; 2006 Jul;135(1):1-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ovine pulmonary adenocarcinoma (OPA) and enzootic nasal adenocarcinoma (ENA) are two contagious neoplastic diseases of secretory epithelial cells in the respiratory system of sheep and goats.
  • [MeSH-major] Adenocarcinoma / veterinary. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Nose Neoplasms / enzymology. Nose Neoplasms / veterinary. Pulmonary Adenomatosis, Ovine / enzymology. Pulmonary Adenomatosis, Ovine / pathology. Signal Transduction


25. Huo Z, Liu HR, Wan JW: [Atypical adenomatous hyperplasia of lung: clinicopathologic study of 8 cases and review of literature]. Zhonghua Bing Li Xue Za Zhi; 2007 May;36(5):292-6
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  • Three patients had past history of non-pulmonary tumors, while 4 patients had lung adenocarcinoma.
  • There was no evidence of local recurrence or disease progression in the 7 patients with post-operative follow-up information available (mean duration of follow up = 23 months).
  • Four cases of AAH were associated with pulmonary adenocarcinoma.
  • CONCLUSIONS: AAH of lung is associated with pulmonary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenomatosis, Pulmonary / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17706134.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / P16 protein, human; 0 / TTF1 protein, human
  • [Number-of-references] 18
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26. Summers C, Dewar P, van der Molen R, Cousens C, Salvatori D, Sharp JM, Griffiths DJ, Norval M: Jaagsiekte sheep retrovirus-specific immune responses induced by vaccination: a comparison of immunisation strategies. Vaccine; 2006 Mar 10;24(11):1821-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Jaagsiekte sheep retrovirus (JSRV) is the aetiological agent of ovine pulmonary adenocarcinoma (OPA).
  • [MeSH-major] Jaagsiekte sheep retrovirus / immunology. Pulmonary Adenomatosis, Ovine / prevention & control. Vaccination / methods

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  • (PMID = 16289765.001).
  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antibodies, Viral; 0 / Lipids; 0 / Vaccines, Subunit; 0 / Vaccines, Synthetic; 0 / Viral Proteins; 0 / incomplete Freund's adjuvant; 9007-81-2 / Freund's Adjuvant
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27. Morandi L, Asioli S, Cavazza A, Pession A, Damiani S: Genetic relationship among atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and adenocarcinoma of the lung. Lung Cancer; 2007 Apr;56(1):35-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma, Bronchiolo-Alveolar / genetics. Adenomatosis, Pulmonary / genetics. Lung Neoplasms / genetics. Precancerous Conditions / genetics

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  • (PMID = 17241687.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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28. Hudachek SF, Kraft SL, Thamm DH, Bielefeldt-Ohmann H, DeMartini JC, Miller AD, Dernell WS: Lung tumor development and spontaneous regression in lambs coinfected with Jaagsiekte sheep retrovirus and ovine lentivirus. Vet Pathol; 2010 Jan;47(1):148-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring and experimentally inducible lung cancer of sheep caused by Jaagsiekte sheep retrovirus (JSRV).
  • However, not only was OPA disease progression observed, but the apparent spontaneous regression of OPA was witnessed.
  • Overall, the genetic profile combined with the disease development data provides further important characterization of OPA and describes, for the first time, spontaneous regression of OPA tumors in experimentally infected sheep.
  • [MeSH-major] Jaagsiekte sheep retrovirus. Lentivirus Infections / veterinary. Lentiviruses, Ovine-Caprine. Lung Neoplasms / veterinary. Pulmonary Adenomatosis, Ovine / pathology. Sheep Diseases / virology

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  • (PMID = 20080496.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 59116
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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29. Kohno T, Kunitoh H, Suzuki K, Yamamoto S, Kuchiba A, Matsuno Y, Yanagitani N, Yokota J: Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias. Carcinogenesis; 2008 May;29(5):957-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC).
  • [MeSH-minor] Adenomatosis, Pulmonary / epidemiology. Adenomatosis, Pulmonary / genetics. Aged. Antigens, Neoplasm / genetics. Antigens, Nuclear / genetics. DNA, Neoplasm / blood. DNA, Neoplasm / genetics. DNA, Neoplasm / isolation & purification. Female. Humans. Hyperplasia / complications. Hyperplasia / epidemiology. Hyperplasia / genetics. Japan / epidemiology. Male. Middle Aged. Risk Factors. Smoking / epidemiology

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  • (PMID = 18299280.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Antigens, Nuclear; 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / PASD1 protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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30. Motoi N, Kishi K, Fujii T, Tsuboi E, Ohashi K, Yoshimura K: Multiple bronchioloalveolar carcinomas in acromegaly: a potential role of insulin-like growth factor I in carcinogenesis. Lung Cancer; 2006 Nov;54(2):247-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Acromegaly / complications. Adenocarcinoma, Bronchiolo-Alveolar / etiology. Adenomatosis, Pulmonary / etiology. Insulin-Like Growth Factor I / physiology. Lung Neoplasms / etiology. Neoplasms, Multiple Primary / etiology

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  • (PMID = 16942817.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 67763-96-6 / Insulin-Like Growth Factor I; EC 2.7.10.1 / Receptor, IGF Type 1
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31. Gradowski JF, Mantha GS, Hunt JL, Dacic S: Molecular alterations in atypical adenomatous hyperplasia occurring in benign and cancer-bearing lungs. Diagn Mol Pathol; 2007 Jun;16(2):87-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatosis, Pulmonary / genetics. Loss of Heterozygosity. Lung / pathology. Lung Neoplasms / genetics. Precancerous Conditions / genetics

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  • (PMID = 17525677.001).
  • [ISSN] 1052-9551
  • [Journal-full-title] Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • [ISO-abbreviation] Diagn. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Genetic Markers
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32. Ohi S, Matsushita K, Neyatani H, Suzuki K, Kazui T: [Surgical therapy for impalpable small lung lesion; confirmation method by means of combining computed tomography (CT)-guided marking with soft X-ray radiography]. Kyobu Geka; 2006 Jul;59(7):543-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenomatosis, Pulmonary / radiography. Lung / radiography. Lung Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 16856528.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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33. Grego E, De Meneghi D, Alvarez V, Benito AA, Minguijón E, Ortín A, Mattoni M, Moreno B, Pérez de Villarreal M, Alberti A, Capucchio MT, Caporale M, Juste R, Rosati S, De las Heras M: Colostrum and milk can transmit jaagsiekte retrovirus to lambs. Vet Microbiol; 2008 Aug 25;130(3-4):247-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ovine pulmonary adenocarcinoma (OPA) is a contagious disease caused by jaagsiekte sheep retrovirus (JSRV).
  • [MeSH-major] Colostrum / virology. Infectious Disease Transmission, Vertical / veterinary. Jaagsiekte sheep retrovirus. Milk / virology. Pulmonary Adenomatosis, Ovine / transmission

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  • (PMID = 18328646.001).
  • [ISSN] 0378-1135
  • [Journal-full-title] Veterinary microbiology
  • [ISO-abbreviation] Vet. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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34. Sartori G, Cavazza A, Bertolini F, Longo L, Marchioni A, Costantini M, Barbieri F, Migaldi M, Rossi G: A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis. Am J Clin Pathol; 2008 Feb;129(2):202-10
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  • Atypical adenomatous hyperplasia (AAH) is considered the preinvasive lesion of pulmonary adenocarcinoma, and mutations of EGFR, HER2, and K-ras are involved in the early stage of lung adenocarcinoma carcinogenesis, also predicting clinical response to anti-EGFR small molecule inhibitors.
  • [MeSH-minor] Adenomatosis, Pulmonary / genetics. Adult. Aged. Base Sequence. DNA Mutational Analysis. Female. Humans. Male. Middle Aged. Molecular Sequence Data

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  • [CommentIn] Am J Clin Pathol. 2008 Aug;130(2):315-6; author reply 316 [18697292.001]
  • (PMID = 18208799.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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35. Kozuki T, Hisamoto A, Tabata M, Takigawa N, Kiura K, Segawa Y, Nakata M, Mandai K, Eguchi K, Ueoka H, Tanimoto M: Mutation of the epidermal growth factor receptor gene in the development of adenocarcinoma of the lung. Lung Cancer; 2007 Oct;58(1):30-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recently, a mutation of the epidermal growth factor receptor (EGFR) gene has been reported to be implicated in the development of pulmonary adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Adenomatosis, Pulmonary / genetics. Genes, erbB-1. Lung Neoplasms / genetics. Mutation. Neoplasms, Multiple Primary / genetics. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Drug Resistance, Neoplasm. Exons. Female. Genetic Predisposition to Disease. Humans. Male. Quinazolines / therapeutic use. Retrospective Studies

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  • (PMID = 17561305.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
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36. Dakessian RM, Inoshima Y, Fan H: Tumors in mice transgenic for the envelope protein of Jaagsiekte sheep retrovirus. Virus Genes; 2007 Aug;35(1):73-80
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer in sheep.
  • [MeSH-major] Adenocarcinoma / genetics. Genes, env. Jaagsiekte sheep retrovirus / genetics. Lung Neoplasms / genetics. Pulmonary Adenomatosis, Ovine / genetics
  • [MeSH-minor] Animals. Disease Models, Animal. Embryo, Mammalian. Female. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Transgenic. Models, Biological. Pregnancy. Sheep

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  • (PMID = 17043760.001).
  • [ISSN] 0920-8569
  • [Journal-full-title] Virus genes
  • [ISO-abbreviation] Virus Genes
  • [Language] eng
  • [Grant] United States / PHS HHS / / 82564; United States / NCI NIH HHS / CA / CA94188
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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37. Nakanishi K, Matsuo H, Kanai Y, Endou H, Hiroi S, Tominaga S, Mukai M, Ikeda E, Ozeki Y, Aida S, Kawai T: LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Virchows Arch; 2006 Feb;448(2):142-50
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenomatosis, Pulmonary / pathology. Large Neutral Amino Acid-Transporter 1 / genetics. Lung / metabolism. Lung Neoplasms / pathology

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  • (PMID = 16175382.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Large Neutral Amino Acid-Transporter 1; 0 / RNA, Messenger
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38. Arnaud F, Varela M, Spencer TE, Palmarini M: Coevolution of endogenous betaretroviruses of sheep and their host. Cell Mol Life Sci; 2008 Nov;65(21):3422-32
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Jaagsiekte sheep retrovirus (JSRV) is a pathogenic exogenous retrovirus and the causative agent of ovine pulmonary adenocarcinoma.

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  • (PMID = 18818869.001).
  • [ISSN] 1420-9071
  • [Journal-full-title] Cellular and molecular life sciences : CMLS
  • [ISO-abbreviation] Cell. Mol. Life Sci.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD052745; United States / NICHD NIH HHS / HD / HD052745
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Retroviridae Proteins, Oncogenic
  • [Number-of-references] 73
  • [Other-IDs] NLM/ NIHMS634040; NLM/ PMC4207369
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39. Wootton SK, Metzger MJ, Hudkins KL, Alpers CE, York D, DeMartini JC, Miller AD: Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV. Retrovirology; 2006 Dec 19;3:94
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, the mouse and sheep tumors have not been carefully compared to determine if Env expression alone in mice can account for the disease features observed in sheep, or whether additional aspects of virus replication in sheep are important, such as oncogene activation following retrovirus integration into the host cell genome.

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  • (PMID = 17177996.001).
  • [ISSN] 1742-4690
  • [Journal-full-title] Retrovirology
  • [ISO-abbreviation] Retrovirology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA009229; United States / NCI NIH HHS / CA / CA09229
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gene Products, env
  • [Other-IDs] NLM/ PMC1764900
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40. Herrejón A, Cervera A, Maciá M, Ferrer R, Blanquer R: [Bronchioloalveolar adenoma associated with bronchiolitis obliterans and leishmaniasis with lung involvement in acquired immunodeficiency syndrome]. Arch Bronconeumol; 2005 Apr;41(4):233-5
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Adenoma bronquioloalveolar asociado a bronquiolitis obliterante y leishmaniasis pulmonar en el sida.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Adenomatosis, Pulmonary / diagnosis. Bronchiolitis Obliterans / diagnosis. Leishmaniasis / diagnosis. Lung Diseases, Parasitic / diagnosis


41. Sun S, Schiller JH, Gazdar AF: Lung cancer in never smokers--a different disease. Nat Rev Cancer; 2007 Oct;7(10):778-90
SciCrunch. KEGG: Data: Disease Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung cancer in never smokers--a different disease.
  • This Review summarizes our current knowledge of this unique and poorly understood disease.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Animals. Carcinoma, Small Cell / epidemiology. Carcinoma, Small Cell / genetics. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Causality. Comorbidity. Cooking. Environmental Exposure / statistics & numerical data. Estrogens / metabolism. Female. Genetic Predisposition to Disease / epidemiology. Global Health. Humans. Incidence. Male. Mutation. Papillomavirus Infections / epidemiology. Polycyclic Hydrocarbons, Aromatic. Pulmonary Adenomatosis, Ovine / epidemiology. Radon. Risk Factors. Sex Distribution. Sheep. Smoking / epidemiology. Smoking / pathology. Tobacco Smoke Pollution / statistics & numerical data

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  • (PMID = 17882278.001).
  • [ISSN] 1474-1768
  • [Journal-full-title] Nature reviews. Cancer
  • [ISO-abbreviation] Nat. Rev. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA070907
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogens; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Tobacco Smoke Pollution; Q74S4N8N1G / Radon
  • [Number-of-references] 163
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42. Varela M, Spencer TE, Palmarini M, Arnaud F: Friendly viruses: the special relationship between endogenous retroviruses and their host. Ann N Y Acad Sci; 2009 Oct;1178:157-72
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Friendly viruses: the special relationship between endogenous retroviruses and their host.
  • Endogenous retroviruses (ERVs) are present in the genome of all vertebrates and have coevolved with their hosts for millions of years.
  • Some ERVs play a critical role in placental development, contribute to genome plasticity, and protect the host against infection of related pathogenic and exogenous retroviruses, thus some ERVs have been positively selected and maintained in the host genome.
  • The sheep genome contains 27 endogenous retroviruses (enJSRVs) related to the pathogenic Jaagsiekte sheep retrovirus (JSRV), the causative agent of a transmissible lung cancer in sheep. enJSRVs are able to protect their host against JSRV infection by blocking different steps of the viral replication cycle.
  • In addition, enJSRVs are absolutely required for sheep placental development.
  • Thus, enJSRVs-JSRV provides a unique and interesting model to study the symbiotic relationship and interplay between host ERVs and evolution.
  • This review will provide some examples of the biological functions of ERvs. In particular, the role of ERVs in reproductive biology and in protecting the host against pathogenic retrovirus infections will be emphasized using enJSRVs/JSRV and the sheep as a model.

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  • (PMID = 19845636.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD052745; United States / NICHD NIH HHS / HD / HD052745; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS634039; NLM/ PMC4199234
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43. McGee-Estrada K, Fan H: In vivo and in vitro analysis of factor binding sites in Jaagsiekte sheep retrovirus long terminal repeat enhancer sequences: roles of HNF-3, NF-I, and C/EBP for activity in lung epithelial cells. J Virol; 2006 Jan;80(1):332-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma, a contagious lung cancer of sheep that arises from type II pneumocytes and Clara cells of the lung epithelium.

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  • (PMID = 16352558.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / T32 CA009054; United States / NCI NIH HHS / CA / R01 CA82654; United States / PHS HHS / / T32A09054
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Proteins; 0 / NF-kappa B; 0 / Transcription Factors; 135845-92-0 / Hepatocyte Nuclear Factor 3-beta
  • [Other-IDs] NLM/ PMC1317537
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44. Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y: Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung. Mod Pathol; 2007 Sep;20(9):967-73
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / genetics. Adenomatosis, Pulmonary / genetics. Gene Expression Regulation, Neoplastic. Lung Neoplasms / genetics. Mutation. Receptor, Epidermal Growth Factor / genetics
  • [MeSH-minor] Adult. Aged. Asian Continental Ancestry Group / genetics. Codon. DNA Mutational Analysis. Disease Progression. Exons. Female. Genes, ras. Humans. Hyperplasia. Japan. Male. Middle Aged

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  • (PMID = 17618248.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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45. Soh J, Toyooka S, Ichihara S, Asano H, Kobayashi N, Suehisa H, Otani H, Yamamoto H, Ichimura K, Kiura K, Gazdar AF, Date H: Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung. J Thorac Oncol; 2008 Apr;3(4):340-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung.
  • INTRODUCTION: We investigated EGFR and KRAS alterations among atypical adenomatous hyperplasia and small lung adenocarcinomas with bronchioloalveolar features to understand their role during multistage pathogenesis.
  • METHODS: Sixty lesions measuring 2 cm or less were studied, including 38 noninvasive lesions (4 atypical adenomatous hyperplasias, 19 Noguchi type A and 15 type B) and 22 invasive lesions (type C) based on the World Health Organization classification and Noguchi's criteria.
  • EGFR and KRAS mutations were examined using PCR-based assays.
  • EGFR copy number was evaluated using fluorescence in situ hybridization.
  • RESULTS: EGFR and KRAS mutations were found in 26 (43.3%) and 5 (8.3%) lesions, respectively.
  • Increased EGFR copy number status was identified in 10 lesions (16.7%), both mutant and wild type.
  • EGFR or KRAS mutations were present in 39.5% and 7.9% (respectively) of noninvasive lesions and 50% or 9.1% (respectively) of invasive lesions.
  • EGFR copy number was increased in 7.9% and 31.8% of noninvasive and invasive lesions (P = 0.029).
  • Multivariate analysis revealed that increased EGFR copy number was the only significant factor to associate with invasive lesions (P = 0.035).
  • CONCLUSIONS: EGFR and KRAS mutations occur early during the multistage pathogenesis of peripheral lung adenocarcinomas.
  • By contrast, increased EGFR copy number is a late event during tumor development and plays a role in the progression of lung adenocarcinoma independent of the initiating molecular events.

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  • (PMID = 18379350.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA084971-09; United States / NCI NIH HHS / CA / CA084971-09; United States / NCI NIH HHS / CA / P50CA70907; United States / NCI NIH HHS / CA / U01 CA084971; United States / NCI NIH HHS / CA / P50 CA070907-05S30003; United States / NCI NIH HHS / CA / P50 CA070907; United States / NCI NIH HHS / CA / CA070907-05S30003
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS137273; NLM/ PMC2758162
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46. Cousens C, Graham M, Sales J, Dagleish MP: Evaluation of the efficacy of clinical diagnosis of ovine pulmonary adenocarcinoma. Vet Rec; 2008 Jan 19;162(3):88-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the efficacy of clinical diagnosis of ovine pulmonary adenocarcinoma.
  • [MeSH-major] Jaagsiekte sheep retrovirus / isolation & purification. Lung / pathology. Pulmonary Adenomatosis, Ovine / diagnosis

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  • (PMID = 18204033.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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47. Rocca S, Sanna MP, Leoni A, Cossu A, Lissia A, Tanda F, Satta MP, Palmieri G: Presence of Jaagsiekte sheep retrovirus in tissue sections from human bronchioloalveolar carcinoma depends on patients' geographical origin. Hum Pathol; 2008 Feb;39(2):303-4
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / virology. Jaagsiekte sheep retrovirus / isolation & purification. Lung Neoplasms / virology. Pulmonary Adenomatosis, Ovine / virology

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  • (PMID = 18206499.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / DNA, Viral
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48. Brambilla E, Lantuejoul S: Telomerase activation in adenocarcinoma-bronchioloalveolar carcinoma. Eur Respir J; 2006 Jun;27(6):1079-81
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma, Bronchiolo-Alveolar / genetics. Disease Models, Animal. Jaagsiekte sheep retrovirus / genetics. Lung Neoplasms / genetics. Pulmonary Adenomatosis, Ovine / genetics. Telomerase / genetics
  • [MeSH-minor] Animals. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Enzyme Activation / genetics. Gene Expression Regulation / genetics. Humans. Hyperplasia. Pulmonary Alveoli / pathology. Sheep

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  • [CommentOn] Eur Respir J. 2006 Jun;27(6):1175-82 [16455826.001]
  • (PMID = 16772385.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.7.49 / Telomerase
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