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1. Guan J, Chen J, Luo YF, Cao JL, Zhao H, Hao J: [Expression of survivin in colorectal adenoma and adenocarcinoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2007 Jun;29(3):398-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of survivin in colorectal adenoma and adenocarcinoma].
  • METHODS Immunohistochemistry staining was performed by two-step EnVision technique for the paraffin sections, which included 90 adenomas, 25 ademomas with high-grade glandular intraepithelial neoplasia, and 108 colorectal adenocarcinomas.
  • The positive rate of SVV in tubular adenomas, villous adenomas, and tubulovillous adenomas were 30% (12/40), 40.9% (9/22), and 35.8% (10/28), respectively.
  • The positive rate of SVV in tubulovillous adenomas with high-grade glandular intraepithelial neoplasia were 68% (17/25).
  • SVV expressions among the three types of adenomas without neoplasia were not significantly different (P > 0.05).
  • SVV expression between each type of the above-mentioned ademoma and tubulovillous adenoma with high-grade glandular intraepithelial neoplasia or different Dukes stages of colorectal carcinoma was significantly different (P < 0.05).
  • SVV expressions in adenocarcinomas and adenomas with high grade glandular intraepithelial neoplasia were significantly higher than those in adenomas (P < 0.01).
  • SVV expression may be useful to distinguish adenocarcinoma from adenoma in colorectal carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Microtubule-Associated Proteins / biosynthesis

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  • (PMID = 17633470.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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2. Park ET, Oh HK, Gum JR Jr, Crawley SC, Kakar S, Engel J, Leow CC, Gao WQ, Kim YS: HATH1 expression in mucinous cancers of the colorectum and related lesions. Clin Cancer Res; 2006 Sep 15;12(18):5403-10
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  • EXPERIMENTAL DESIGN: Immunohistochemistry and confocal microscopy was used to examine HATH1 expression and subcellular distribution in normal colon and small intestine, mucinous cancers, signet ring carcinomas, and nonmucinous cancers and in precursor lesions, including hyperplastic polyps, serrated adenomas, tubular adenomas, and villous adenomas.
  • HATH1 was found to be strongly expressed in the nuclei of hyperplastic polyps, serrated adenomas, villous adenomas, mucinous cancers, and signet ring carcinomas but repressed in nonmucinous cancers and tubular adenomas.
  • In addition, the expression of HATH1 in hyperplastic polyps, serrated adenomas, and villous adenomas lends support to the hypothesis that these neoplasms are frequent precursors in mucinous cancer and signet ring carcinoma development.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Humans. Intestinal Polyps / pathology. Intestines / cytology. Intestines / ultrastructure. Male. Microscopy, Fluorescence. Middle Aged. Mucin-2. Mucins / metabolism. Promoter Regions, Genetic. Tissue Distribution. Transcriptional Activation

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  • (PMID = 17000673.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATOH1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / MUC2 protein, human; 0 / Muc2 protein, mouse; 0 / Mucin-2; 0 / Mucins
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3. Brenner BM, Stoler DL, Rodriguez L, Karpenko MJ, Swede H, Petrelli NJ, Anderson GR: Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers. Cancer Genet Cytogenet; 2007 Apr 1;174(1):9-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers.
  • Allelic imbalances in premalignant villous adenomas were compared with those in adjacent microdissected colorectal carcinoma that had arisen directly from the adenomas.
  • Carcinoma-adenoma pairs were examined from 17 patients who underwent resections for colorectal cancer.
  • Loss of heterozygosity for multiple markers was found in 35% of adenomas and 65% of carcinomas; the average fractional allelic loss rate was 2.5 times higher in carcinomas than in adenomas.
  • Of the 17 patients, 4 had MSI for >30% of markers in both adenoma and carcinoma, with no significant differences between the two tissues.
  • Markers with particularly high imbalance rates in adenomas were seen on chromosomes 11, 14, and 15.
  • These findings provide further evidence that genomic instability is an ongoing process during carcinogenesis, with a markedly increased frequency of allelic losses seen in carcinomas, compared with adjacent adenomas.

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  • (PMID = 17350461.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA074127; United States / NCI NIH HHS / CA / R01 CA074127-07; United States / NCI NIH HHS / CA / R01CA74127
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS20123; NLM/ PMC1855249
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4. Krstic M, Alempijevic T, Stimec B, Micev M, Milicevic M, Micic D, Jankovic G: Gallbladder villous adenoma in a patient with acromegaly: a case report. World J Gastroenterol; 2007 Jun 14;13(22):3144-6
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  • [Title] Gallbladder villous adenoma in a patient with acromegaly: a case report.
  • Villous adenomas are benign epithelial lesions with malignant potential that can occur in any part of the gastrointestinal tract.
  • An open cholecystectomy was performed and revealed a villous adenoma with several foci of carcinoma in situ.
  • [MeSH-major] Acromegaly. Adenoma, Villous / ultrasonography. Gallbladder Neoplasms / ultrasonography

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  • (PMID = 17589936.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4172627
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5. Sung W, Park BD, Lee S, Chang SG: Villous adenoma of the urinary bladder. Int J Urol; 2008 Jun;15(6):551-3
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  • [Title] Villous adenoma of the urinary bladder.
  • Villous adenomas arising in the urinary tract are an uncommon occurrence.
  • Villous adenomas arising in the bladder are rare tumors that have been described as isolated cases and a few case series.
  • We report a new case of a large villous adenoma arising in the bladder that was treated by transurethral resection.
  • [MeSH-major] Adenoma, Villous / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 18489648.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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6. Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr: Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal. World J Gastroenterol; 2009 Jul 28;15(28):3560-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal.
  • In particular, adenomas and adenocarcinomas are distinctly rare entities in this region.
  • We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.
  • Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma.
  • Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Anal Canal / pathology
  • [MeSH-minor] Aged, 80 and over. Cell Transformation, Neoplastic / pathology. Disease Progression. Humans. Male. Treatment Outcome

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  • (PMID = 19630115.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2715986
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7. Farag M, Saklani A, N NN, Masoud A: The Red Rectum (Carpet villous adenoma of the rectum). J Surg Case Rep; 2010;2010(10):10

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  • [Title] The Red Rectum (Carpet villous adenoma of the rectum).
  • Carpeted villous adenomas of rectum may be extensive and not suitable for transanal excision or Endoscopic mucosal resection.

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  • [Copyright] © JSCR.
  • (PMID = 24945847.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649181
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8. Anderson JC, Latreille M, Messina C, Alpern Z, Grimson R, Martin C, Hubbard P, Shaw RD: Smokers as a high-risk group: data from a screening population. J Clin Gastroenterol; 2009 Sep;43(8):747-52
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  • Our outcome was endoscopically detected significant colorectal neoplasia that included large (>1 cm) tubular adenomas, villous adenomas, multiple (3 or more) adenomas, high-grade dysplasia, and adenocarcinoma.
  • [MeSH-major] Adenocarcinoma. Adenoma. Colorectal Neoplasms. Smoking / adverse effects

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  • (PMID = 19407663.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Cole BF, Logan RF, Halabi S, Benamouzig R, Sandler RS, Grainge MJ, Chaussade S, Baron JA: Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. J Natl Cancer Inst; 2009 Feb 18;101(4):256-66
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  • [Title] Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.
  • Randomized clinical trials have been conducted to evaluate the effectiveness of aspirin for reducing the risk of colorectal adenomas.
  • METHODS: We combined data from all randomized double-blind placebo-controlled trials that evaluated aspirin for the prevention of colorectal adenomas.
  • We used random-effects meta-analysis to estimate risk ratios and 95% confidence intervals (CIs) for the effect of aspirin on the occurrence of adenomas and of advanced lesions (ie, tubulovillous adenomas, villous adenomas, adenomas >or=1 cm in diameter, adenomas with high-grade dysplasia, or invasive cancer).
  • Each trial evaluated aspirin for the secondary prevention of colorectal adenomas.
  • A total of 2698 participants underwent colonoscopic follow-up and were included in the analysis of adenoma occurrence and advanced-lesion occurrence after randomization.
  • Among these participants, adenomas were found in 424 (37%) of the 1156 participants allocated to placebo and in 507 (33%) of the 1542 participants allocated to any dose of aspirin.
  • The pooled risk ratio of any adenoma for any dose of aspirin vs placebo was 0.83 (95% CI = 0.72 to 0.96).
  • CONCLUSION: Aspirin is effective for the prevention of colorectal adenomas in individuals with a history of these lesions.
  • [MeSH-major] Adenoma / prevention & control. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Anticarcinogenic Agents / administration & dosage. Aspirin / administration & dosage. Colorectal Neoplasms / prevention & control. Neoplasm Recurrence, Local / prevention & control


10. Frickmann H, Jungblut S, Bargon J, Willenbrock K, Störkel S, Hanke P: [Villous adenoma of the renal pelvis and ureter]. Urologe A; 2006 Nov;45(11):1435-7
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  • [Title] [Villous adenoma of the renal pelvis and ureter].
  • [Transliterated title] Villöses Adenom des Nierenbeckens und Ureters.
  • Villous adenomas of the urinary tract are extremely rare tumours belonging to the adenoepithelial metaplasias.
  • We describe the case of an 85-year-old female patient suffering from a villous adenoma of the renal pelvis and ureter.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Kidney Neoplasms / diagnosis. Kidney Pelvis. Neoplasms, Multiple Primary / diagnosis. Ureteral Neoplasms / diagnosis

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  • (PMID = 16900367.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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11. Decker CJ: Transanal excision of rectal villous adenomas by laparoscopic methods. J Laparoendosc Adv Surg Tech A; 2005 Feb;15(1):23-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal excision of rectal villous adenomas by laparoscopic methods.
  • Large villous adenomas of the rectum are not uncommon and will be encountered often by general and colorectal surgeons in their practices.
  • The approach to large adenomas can be via the colonoscope either transabdominally or transanally.
  • The method is simple and allows access to lesions up to 15 cm from the anal verge with a low incidence of complications, residual disease, and recurrence.
  • [MeSH-major] Adenoma, Villous / surgery. Laparoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 15772472.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Arslan N, Dehdashti F, Siegel BA: FDG uptake in colonic villous adenomas. Ann Nucl Med; 2005 Jun;19(4):331-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG uptake in colonic villous adenomas.
  • Colonic adenomas constitute 70-80% of all colorectal polyps, and their clinical significance relates primarily to their relationship with colorectal cancer.
  • The purpose of this study was to investigate the rate of FDG-PET positivity within colonic villous adenomas.
  • A pathology database search was performed to identify all patients diagnosed with colonic villous adenoma between June 1, 1996 and December 1, 2000.
  • Patients with a pathologic diagnosis of colonic villous adenoma and who also had a FDG-PET study up to 1 month before colonoscopy were included in this study.
  • Of more than 4,000 patients, six patients were diagnosed with colonic adenoma on subsequent colonoscopy following FDG-PET study.
  • Based on the pathological findings, these 6 patients had a total of 2 villous and 9 tubulovillous adenomas.
  • Five of the 6 patients showed foci of increased FDG uptake in the region of the colon that corresponded to the villous adenoma(s) detected on colonoscopy, which accounted for a true-positive rate of 83.3% (5/6 subjects).
  • Focal lesions in the colon seen on FDG-PET examinations need to be investigated further, even though some of these will prove to be villous adenomas rather than colorectal carcinomas.
  • [MeSH-major] Adenoma, Villous / radionuclide imaging. Colorectal Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18 / pharmacokinetics. Positron-Emission Tomography / methods

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  • (PMID = 16097645.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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13. Nguyen AV, Albers CG, Holcombe RF: Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. Int J Mol Med; 2010 Jul;26(1):121-5
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  • [Title] Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles.
  • This study was undertaken to define whether differences in the expression of Wnt pathway components are present between normal colonic mucosa, early (tubular) adenomas and villous adenomas which have a higher malignant potential.
  • Normal mucosa, tubular adenomas and villous adenomas were obtained from twelve patients.
  • Fifteen Wnt pathway-related genes showed differential expression between villous adenomas and normal mucosa and villous and tubular adenomas at a significance level of p<0.01.
  • Genes involved in canonical Wnt (beta-catenin) signaling with increased expression in villous adenomas included wnt1, fz2, csnk2A2, pygo2, pygo1, frat2 and myc, the latter confirmed by qRT-PCR and IHC.
  • Myc protein expression was confined primarily to stromal components of villous adenomas.
  • Genes involved in non-canonical Wnt signaling with increased expression in villous adenomas included rho-u, daam1, damm2, cxxc4 and nlk.
  • Successive increases in the expression of ctnnb1 (beta-catenin) from normal to tubular adenomas to villous adenomas was seen.
  • The Wnt pathway gene expression profile can differentiate between tubular and villous adenomas.
  • These data suggest that Wnt signaling regulation changes during the progression from normal mucosa to tubular adenomas to villous adenomas.
  • Expression of Myc in adenoma stroma suggests a dynamic signaling network within adenomas between mucosal and stromal elements.
  • Inhibition of the Wnt pathway may provide a novel approach for cancer prevention in patients with benign tubular adenomas.
  • [MeSH-major] Adenoma / genetics. Adenoma, Villous / genetics. Colonic Neoplasms / genetics. Gene Expression Profiling. Signal Transduction / genetics

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  • (PMID = 20514431.001).
  • [ISSN] 1791-244X
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA82450
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Wnt Proteins
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14. Kakar S, Deng G, Cun L, Sahai V, Kim YS: CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. Hum Pathol; 2008 Jan;39(1):30-6
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  • [Title] CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.
  • We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS mutations and methylation at hMLH1, p16, HIC1, RASSF2, MGMT, MINT1, and MINT31.
  • CIMP-positive status (methylation at 3 or more loci) was observed in 44% tubulovillous/villous adenomas compared with 8 (27%) of 30 tubular adenomas (P = .08).
  • Tubulovillous/villous adenomas showed significantly higher methylation than tubular adenomas at MGMT (87% vs 37%, P < .01) and RASSF2 (94% vs 70%, P = .02).
  • There was no significant difference in methylation of HIC1, MINT1, MINT31, and p16. hMLH1 methylation was absent in all tubulovillous/villous adenomas and seen in only 2 (7%) tubular adenomas.
  • CIMP-positive status correlated with large size, right-sided location, and amount of villous component in tubulovillous/villous adenomas.
  • BRAF V600E mutation was not observed in any tubular adenoma or tubulovillous/villous adenoma.
  • KRAS mutations were seen in 9% of tubulovillous/villous adenomas and 10% of tubular adenomas.
  • In conclusion, CIMP-positive phenotype is common in tubulovillous/villous adenomas and increases with large size, right-sided location, and amount of villous component.
  • Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma.
  • BRAF mutations are absent in tubulovillous/villous adenomas.
  • [MeSH-major] Adenoma, Villous / genetics. Adenoma, Villous / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. CpG Islands. DNA Methylation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. ras Proteins / genetics
  • [MeSH-minor] Disease Progression. Humans. Microsatellite Instability

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  • (PMID = 17950780.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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15. Sierra-Montenegro E, Rocha-Ramírez JL, Villaneuva-Sáenz E, de la Serna-Ortiz I, Fernández-Rivero JM, Soto-Quirino R: [Villous adenoma of the rectum with severe hydroelectric alterations. Report of two cases]. Cir Cir; 2007 Sep-Oct;75(5):377-9
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  • [Title] [Villous adenoma of the rectum with severe hydroelectric alterations. Report of two cases].
  • [Transliterated title] Adenoma velloso de recto con alteración hidroelectrolítica severa. Informe de dos casos.
  • BACKGROUND: Approximately 10% of all colorectal adenomas are constituted by villous adenomas.
  • We report two cases with villous adenoma that presented hydroelectrolytic depletion with clinical and surgical management, exclusively.
  • We also performed a transanal resection of tumor reporting villous adenoma.
  • CONCLUSIONS: Size and location of the villous adenoma are related to the production of mucus secretory diarrhea.
  • In every patient with presence of mucus, persistent diarrhea and occasional rectal bleeding of 1 month, it is necessary to carry out lower endoscopy to rule out the presence of villous adenoma.
  • [MeSH-major] Adenoma, Villous / complications. Rectal Neoplasms / complications. Water-Electrolyte Imbalance / etiology

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  • (PMID = 18158885.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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16. Bosma J, Silvis R: Transanal resection for villous adenomas using the Fansler proctoscope. Acta Chir Belg; 2008 Sep-Oct;108(5):538-41

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  • [Title] Transanal resection for villous adenomas using the Fansler proctoscope.
  • [MeSH-major] Adenoma, Villous / surgery. Proctoscopes. Rectal Neoplasms / surgery

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  • (PMID = 19051462.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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17. Ratanarapee S, Uiprasertkul M, Pradniwat K, Soontrapa S: Villous adenoma of the urinary bladder: a case report. J Med Assoc Thai; 2010 Nov;93(11):1336-9
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  • [Title] Villous adenoma of the urinary bladder: a case report.
  • Villous adenomas of the urinary tract are rare, in contrast to urothelial neoplasms.
  • The histopathology is identical to that of the much more common villous adenoma of the gastrointestinal tract.
  • The authors reported a case of urinary bladder villous adenoma in a 41-year-old Thai patient who complained of hematuria for one day without any other symptom.
  • Transurethral resection was performed Histologic examination revealed typical features of villous adenoma.
  • The tumor showed identical immunohistochemical profile to colonic villous adenoma.
  • [MeSH-major] Adenoma, Villous / pathology. Urethral Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 21114216.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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18. Suppiah A, Barandiaran J, Morgan R, Perry EP: First case of villous adenoma of the appendix leading to acute appendicitis presenting as strangulated femoral hernia: changes in management owing to concurrent adenoma. Hernia; 2008 Feb;12(1):95-8
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  • [Title] First case of villous adenoma of the appendix leading to acute appendicitis presenting as strangulated femoral hernia: changes in management owing to concurrent adenoma.
  • Histology revealed acute inflammation and a villous adenoma of the appendix.
  • Villous adenomas of the vermiform appendix are extremely rare tumours of the gastrointestinal tract.
  • This is the first case combining two very rare pathologies--acute appendicitis presenting as strangulated femoral hernia and villous adenoma of the appendix.
  • Second, the presence of an adenoma changes the aetiology of appendicitis.
  • More importantly, changes in surgical management of acute appendicitis presenting as a strangulated femoral hernia owing to a co-existing adenoma are discussed.
  • [MeSH-major] Adenoma, Villous / complications. Appendiceal Neoplasms / complications. Appendicitis / diagnosis. Appendicitis / etiology. Hernia, Femoral / diagnosis

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  • (PMID = 17566835.001).
  • [ISSN] 1265-4906
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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19. Lane Z, Hansel DE, Epstein JI: Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder. Am J Surg Pathol; 2008 Sep;32(9):1322-6
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  • [Title] Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder.
  • Also included for comparison were 3 cases, each of bladder villous adenomas and bladder adenocarcinoma in situ.
  • Membranous PSMA staining was evident in an additional 3 tumors, 1 urachal mucinous adenocarcinoma, 1 nonurachal mucinous and signet ring cell adenocarcinoma, and 1 nonurachal villous adenoma.
  • In conclusion, although all cases of bladder adenocarcinoma examined were negative for PSA and PSAP, the surprising finding that a subset of invasive and in situ adenocarcinomas of the bladder demonstrated immunoreactivity for P501S and PSMA should warrant caution when using these markers in differentiating prostatic from bladder adenocarcinomas.
  • The lack of granular perinuclear staining for P501S and the absence of membranous PSMA staining both favor a bladder adenocarcinoma, although rare cases of villous adenoma and adenocarcinoma did show PSMA membranous staining indistinguishable from that seen in prostate cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Villous / metabolism. Antigens, Neoplasm / biosynthesis. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 18670358.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Membrane Proteins; 0 / prostein; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
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20. Zarineh A, Bulakhtina E, Olson PR, Silverman JF: Recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum. Case Rep Med; 2009;2009:361212

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  • [Title] Recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum.
  • Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations.
  • We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum.
  • There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia.
  • We also present a brief literature review of urothelial villous adenomas.

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  • [Cites] J Urol. 2008 Dec;180(6):2463-7 [18930487.001]
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  • (PMID = 19718251.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729294
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21. Cubuk R, Tasali N, Arslan G, Midi A, Manukyan MN, Guney S: A giant villous adenoma: case mimicking rectosigmoid malignancy; radiological survey to diagnosis. Prague Med Rep; 2010;111(1):76-81
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  • [Title] A giant villous adenoma: case mimicking rectosigmoid malignancy; radiological survey to diagnosis.
  • Villous adenomas are benign lesions, which are difficult to interpret because of their malignancy potential.
  • Usually, villous adenomas are asymptomatic although they may cause rectal bleeding like malignant tumours.
  • We present a case of giant villous adenoma to evaluate the contribution of its radiological features including double contrast barium enema, computed tomography and magnetic resonance imaging examinations for the differential diagnosis.
  • [MeSH-major] Adenoma, Villous / diagnosis. Colorectal Neoplasms / diagnosis

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  • (PMID = 20359441.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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22. Cho SD, Herzig DO, Douthit MA, Deveney KE: Treatment strategies and outcomes for rectal villous adenoma from a single-center experience. Arch Surg; 2008 Sep;143(9):866-70; discussion 871-2
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  • [Title] Treatment strategies and outcomes for rectal villous adenoma from a single-center experience.
  • OBJECTIVES: To analyze a 13-year, single-surgeon experience with villous adenoma of the rectum with respect to procedure, complications, recurrence, and cancer incidence.
  • PATIENTS: Patients who underwent excision of rectal villous adenoma.
  • CONCLUSIONS: Complete excision is warranted for rectal villous adenomas, as biopsies were accurate only 50% of the time, and 1 in 8 patients had unsuspected cancer found after excision.
  • [MeSH-major] Adenoma, Villous / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18794424.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Koning GG, Rensma PL, van Milligen de Wit AW, van Laarhoven CJ: In-one-continuity rectal excision and anal mucosectomy of a giant villous adenoma: an alternative surgical approach. Case Rep Gastroenterol; 2008;2(2):175-80

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  • [Title] In-one-continuity rectal excision and anal mucosectomy of a giant villous adenoma: an alternative surgical approach.
  • BACKGROUND: The authors present a woman suffering from McKittrick-Wheelock syndrome (MKWS) with a giant rectal villous adenoma.
  • The most frequently reported tumors are villous adenomas.
  • At colonoscopy an 8-cm villous adenoma was seen in the rectum.

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  • (PMID = 21490885.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075139
  • [Keywords] NOTNLM ; Dehydration / Electrolyte disorders / McKittrick-Wheelock syndrome / Rectal surgery / Rectal villous adenoma / Renal failure
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24. Shivaprakash HN, Jayashree K, Girish M: Villous adenoma: a rare tumor of vaginal vault. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):265-6
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  • [Title] Villous adenoma: a rare tumor of vaginal vault.
  • Villous adenomas are extremely rare tumors in the vagina and are indistinguishable from their colonic counterparts.
  • We present a case of villous adenoma of vaginal vault, a rare site of presentation in a 30-year-old female.
  • [MeSH-major] Adenoma, Villous / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18603704.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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25. Rubio CA, Nesi G, Messerini L, Zampi GC, Mandai K, Itabashi M, Takubo K: The Vienna classification applied to colorectal adenomas. J Gastroenterol Hepatol; 2006 Nov;21(11):1697-703
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  • [Title] The Vienna classification applied to colorectal adenomas.
  • In this study, that classification is applied to colorectal adenomas.
  • METHODS: Colorectal adenomas from 1552 patients were histologically classified according to the categories listed in Vienna: category 3, low-grade dysplasia; 4.1, high-grade dysplasia; 4.2, carcinoma in situ; 4.3, suspicious of intramucosal carcinoma; 5.1, intramucosal carcinoma; and 5.2, submucosal carcinoma.
  • Adenomas with dysplasia (categories 3 and 4.1) or with carcinoma (categories 4.2, 4.3, 5.1 and 5.2) were analyzed separately.
  • On basis of their configuration, adenomas were classified into tubular, tubulovillous, villous, serrated, microtubular and combined phenotypes (i.e. other than tubulovillous).
  • RESULTS: The highest percentage of adenomas with carcinoma was found amongst villous adenomas (29.6%), followed by combined adenomas (27.8%).
  • Villous adenoma with carcinoma was the most frequent neoplasia at all ages; combined adenomas with carcinoma were more frequent among younger patients.
  • In elderly patients (> or = 60 years of age) the highest percentage of adenomas with carcinoma was recorded in villous adenomas (28.1%), followed by serrated adenomas (19.2%).
  • Villous adenomas and combined adenomas with carcinoma were more frequent in males.
  • CONCLUSION: The Vienna classification of colorectal adenomas seems to be influenced by parameters inherent to the patient such as age and sex and by the histological phenotype of the adenoma.
  • [MeSH-major] Adenoma / classification. Colorectal Neoplasms / classification

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  • (PMID = 16984592.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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26. Cueto J, Benotto JA, Catalina R, Vazquez-Frias JA: Large duodenal villous adenoma requiring head of the pancreas and pylorus-preserving total duodenectomy. Surg Laparosc Endosc Percutan Tech; 2005 Aug;15(4):230-2; discussion 232-3
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  • [Title] Large duodenal villous adenoma requiring head of the pancreas and pylorus-preserving total duodenectomy.
  • Villous adenomas of the duodenum (VAD) are infrequent lesions of the gastrointestinal tract but have a high risk of recurrence and malignancy.
  • PPTD should be an excellent option in patients with large adenomas because it allows preservation of the pancreas, gastrointestinal function is maintained, the possibility of a recurrence and of an invasive carcinoma of the ampulla is eliminated, and finally because it permits an adequate endoscopic follow-up.
  • [MeSH-major] Adenoma, Villous / surgery. Duodenal Neoplasms / surgery. Duodenum / surgery

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  • (PMID = 16082312.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Hurlstone DP, Sanders DS, Cross SS, George R, Shorthouse AJ, Brown S: A prospective analysis of extended endoscopic mucosal resection for large rectal villous adenomas: an alternative technique to transanal endoscopic microsurgery. Colorectal Dis; 2005 Jul;7(4):339-44
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  • [Title] A prospective analysis of extended endoscopic mucosal resection for large rectal villous adenomas: an alternative technique to transanal endoscopic microsurgery.
  • Patients with T2 or node positive disease were referred for surgery.
  • [MeSH-major] Adenoma, Villous / surgery. Colonoscopy / methods. Intestinal Mucosa / surgery. Rectal Neoplasms / surgery

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  • (PMID = 15932555.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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28. Kirimlioglu H, Kirimlioglu V, Yilmaz S, Sagir V, Coban S, Turkmen E, Hilmioglu F: Role of matrix metalloproteinase-7 in colorectal adenomas. Dig Dis Sci; 2006 Nov;51(11):2068-72
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  • [Title] Role of matrix metalloproteinase-7 in colorectal adenomas.
  • They are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas.
  • In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of colonic adenomas.
  • Although MMP-7 has already been shown to be overexpressed in various types of colonic adenomas, tubular versus villous adenomas had not been further seperated to date.
  • Seventy-six patients had either normal mucosa (n=15) or tubular (n=32), tubulovillous (n=16), or villous (n=13) colonic adenoma.
  • Each adenoma was graded according to the percentage of strongly stained areas in the adenoma as G0, G1, G2, or G3.
  • Sixty-nine percent of villous adenomas showed grade 3 staining of MMP-7, versus none of the tubular adenomas.
  • G0 and G1 staining was not detected in the villous adenomas.
  • The results of the study show that the degrees of overexpression of the three subtypes of colonic adenomas were statistically significantly different.
  • In conclusion, MMP-7 overexpression is thought to be an early event in the adenoma-carcinoma pathway.
  • [MeSH-major] Adenoma / enzymology. Colorectal Neoplasms / enzymology. Matrix Metalloproteinase 7 / physiology
  • [MeSH-minor] Adenoma, Villous / enzymology. Adenoma, Villous / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies

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  • (PMID = 17009118.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
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29. Tomita T: Immunocytochemical localization of lymphatic and venous vessels in colonic polyps and adenomas. Dig Dis Sci; 2008 Jul;53(7):1880-5
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  • [Title] Immunocytochemical localization of lymphatic and venous vessels in colonic polyps and adenomas.
  • Using lymphatic vessels endothelial hyaluronan receptor-1 (LYVE-1) immunocytochemical staining, hyperplastic polyps, tubular adenomas to villous adenomas, were investigated for lymphatic vessels compared with immunostained blood vessels using factor-8.
  • Four cases each of hyperplastic polyps, tubular adenomas to villous adenomas, were routinely fixed in formalin and embedded in paraffin and were immunostained using goat anti-LYVE-1 for lymphatic vessels and rabbit anti-factor-8 for blood vessels.
  • In tubular adenomas, small lymphatic and venous vessels were noted in broad fibrous stalks.
  • In villous adenomas, smaller lymphatic and venous vessels were noted in fine intervillous stroma.
  • In tubular adenomas, small lymphatic and venous vessels were noted in fibrous stalks.
  • In villous adenomas, smaller lymphatic and venous vessels were noted in intervillous stroma.
  • There are no increased lymphatic and venous vessels in intermucosal stroma and stalks of adenomas compared with normal colon.
  • [MeSH-major] Adenoma / blood supply. Colonic Neoplasms / blood supply. Colonic Polyps. Immunohistochemistry / methods. Lymphatic Vessels. Veins

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  • (PMID = 17990106.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / LYVE1 protein, human; 0 / Vesicular Transport Proteins
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30. Carneiro FP, Ramalho LN, Britto-Garcia S, Ribeiro-Silva A, Zucoloto S: Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas. Dis Colon Rectum; 2006 May;49(5):588-94
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  • [Title] Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas.
  • PURPOSE: The aim of this study was to investigate the immunohistochemical expression of p16, p53, and p63 proteins according to some pathologic parameters related to colorectal adenomas and adenocarcinomas such as grade of dysplasia and histologic type.
  • METHODS: Immunohistochemistry with the antibodies p16, p53, and p63 was performed in tubular, tubular-villous, and villous adenomas (n = 30) and in well, moderately, and poorly differentiated adenocarcinomas (n = 30).
  • RESULTS: The p16 and p53 labelings were observed in some adenomas and adenocarcinomas but without any association with p63 expression, histologic type, or grade of differentiation of the neoplasm.
  • P63 expression was found mainly in the villous adenomas and in the poorly differentiated adenocarcinomas.
  • However, p63 expression was closely associated with villous adenomas and poorly differentiated adenocarcinomas.
  • [MeSH-minor] Adenocarcinoma. Adenoma. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. DNA-Binding Proteins. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Keratins / metabolism. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16575619.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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31. Lana E, Brun ME, Rivals I, Selves J, Kirzin S, Lutsyk AP, Gordiyuk VV, Bibeau F, Rynditch A, De Sario A: BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas. Cancers (Basel); 2009;1(1):3-11

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  • [Title] BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas.
  • In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas.
  • Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.

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  • (PMID = 24280968.001).
  • [ISSN] 2072-6694
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3757347
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32. Nusko G, Hahn EG, Mansmann U: Characteristics of metachronous colorectal adenomas found during long-term follow-up: analysis of four subsequent generations of adenoma recurrence. Scand J Gastroenterol; 2009;44(6):736-44
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  • [Title] Characteristics of metachronous colorectal adenomas found during long-term follow-up: analysis of four subsequent generations of adenoma recurrence.
  • OBJECTIVE: Because of the high recurrence rates of colorectal adenomas, regular surveillance by colonoscopy has been recommended, but there is still a dearth of information on the long-term results of follow-up colonoscopy after polypectomy.
  • The aims of this study were to determine the differences between initial adenomas and metachronous lesions, to evaluate the effect of long-term surveillance and to describe the hypothetical origin of the colorectal adenoma-carcinoma sequence.
  • Statistical analysis using chi(2) testing of adenoma characteristics found in four subsequent recurrence periods was carried out, and the relative risk (RR) for the development of metachronous adenomas of advanced pathology was calculated.
  • RESULTS: In comparison with the initial findings, metachronous adenomas are generally significantly smaller lesions (p<0.00001), usually tubular in shape (p<0.00001) and bearing high-grade dysplasia less often (p<0.00001) and are usually located in the right colon (p<0.00001).
  • These differences are found between the initial and four subsequent generations of metachronous adenomas.
  • The number of synchronous adenomas is reduced only in the first recurrence (p<0.001); in the further generations equal proportions of multiplicity are found, as in the baseline examination.
  • Patients with adenomas of advanced pathology, i.e. large, tubulovillous or villous adenomas at baseline, have a significantly higher risk for large (RR 2.73; 95% CI 1.77-4.20), tubulovillous or villous (RR 1.55; 95% CI 1.06-2.25) or multiple (RR 2.45; 95% CI 1.83-3.29) metachronous adenomas at the first recurrence.
  • CONCLUSIONS: Metachronous adenomas show the uniform characteristics of being small tubular lesions rarely bearing high-grade dysplasia, usually located in the right colon.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Neoplasms, Second Primary

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  • (PMID = 19277927.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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33. Psofaki V, Kalogera C, Tzambouras N, Stephanou D, Tsianos E, Seferiadis K, Kolios G: Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas. World J Gastroenterol; 2010 Jul 28;16(28):3553-60
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  • [Title] Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.
  • METHODS: DNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1 (hMLH1), Cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), and O-6-methylguanine DNA methyltransferase (MGMT), as well as their relation to MSI.
  • RESULTS: The frequency of promoter methylation for each locus increased in the sequence healthy tissue/adenoma/carcinoma.
  • MGMT and CDKN2A/p16 presented a statistically significant increase in promoter methylation between the less and more tumorigenic forms of colorectal adenomas (tubular vs tubullovillous and villous adenomas).
  • All patients with tubulovillous/villous adenomas, as well as all colorectal cancer patients, showed promoter methylation in at least one of the examined loci.
  • These findings suggest a potentially crucial role for methylation in the polyp/adenoma to cancer progression in colorectal carcinogenesis.
  • CONCLUSION: Methylation analysis of hMLH1, CDKN2A/p16, and MGMT revealed specific methylation profiles for tubular adenomas, tubulovillous/villous adenomas, and colorectal cancers, supporting the use of these alterations in assessment of colorectal tumorigenesis.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation / physiology. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Nuclear Proteins / genetics. Promoter Regions, Genetic / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Aged. CpG Islands / genetics. Disease Progression. Female. Humans. Male. Microsatellite Repeats / genetics. Middle Aged

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  • (PMID = 20653064.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
  • [Other-IDs] NLM/ PMC2909555
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34. Lakis S, Papamitsou T, Panagiotopoulou C, Kotakidou R, Kotoula V: AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas. World J Gastroenterol; 2010 May 28;16(20):2476-83
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  • [Title] AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas.
  • AIM: To analyze alpha-methylacyl CoA racemase (AMACR) expression in relation to various dysplasia phenotypes and clinicopathological parameters of sporadic colorectal adenomas.
  • METHODS: Fifty-five cases of sporadic colorectal adenomas were categorized according to the Vienna classification for Gastrointestinal Neoplasia.
  • AMACR expression was evaluated by immunohistochemistry and statistical analysis was performed to investigate possible associations with various clinicopathologic parameters of adenomas i.e. gender, age, localization, grade of dysplasia, size and configuration.
  • Adenomas ranged in size between 0.5 and 30 cm (mean 2 +/- 1.3 cm), including 18 tubular, 16 villous, 20 mixed or tubulovillous, and 1 giant sessile villous adenoma.
  • Most adenomas exhibiting high grade dysplasia with in situ carcinoma-like areas stained positive for AMACR (15/17 or 88.2%) as compared to adenomas with high grade dysplasia which contained severe dysplasia-like foci (6/15 or 40%), (P = 0.005).
  • In AMACR positive adenomas featuring severe dysplasia-like or in situ carcinoma-like areas, AMACR staining was not necessarily observed in the in situ component.
  • Positivity in intra-lesion of mild, moderate or severe dysplasia-like foci was more often encountered in adenomas harboring in situ, intramucosal or infiltrative carcinoma [21/33 (63.6%) vs 9/40 (22.5%), P < 0.001].
  • Strong AMACR expression was found in 11 out of 17 villous adenomas, but in only 1 out of 18 tubular lesions (P = 0.005).
  • Overall, AMACR expression was associated with the grade of dysplasia, as well as with the size and configuration of adenomas, i.e. the consensus risk factors applied to colorectal adenoma patient surveillance.
  • CONCLUSION: It may be worthy to further evaluate the possible use of AMACR as an additional risk factor for the assessment of colorectal adenoma patients.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / pathology. Racemases and Epimerases / metabolism

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  • (PMID = 20503447.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
  • [Other-IDs] NLM/ PMC2877177
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35. Zhongyin Z, Hesheng L, Jun L, Jihong C: Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas. Saudi Med J; 2006 Feb;27(2):161-4
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  • [Title] Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas.
  • OBJECTIVE: To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas.
  • Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined.
  • RESULTS: Serum TC levels of colorectal adenomas group (5.32 +/- 0.85 mmol/L), distal colorectal adenomas group (5.58 +/- 0.63 mmol/L), and villous adenoma group (5.49 +/- 0.69 mmol/L) were higher than the control group (4.28 +/- 0.62 mmol/L, p=0.016), proximal colorectal adenomas group (4.82 +/- 0.58 mmol/L, p=0.038) and non-villous adenoma group (4.76 +/- 0.58 mmol/L, p=0.03).
  • Serum HDL-C levels of colorectal adenomas group (1.39 +/- 0.25 mmol/L) were lower than the control group (1.51 +/- 0.29 mmol/L) (p=0.035).
  • Serum lipids levels of each genotype in colorectal adenomas group were not statistically significant.
  • Apolipoprotein E3/E4 genotypic frequency in colorectal adenomas group (7.1%) was lower than the control group (17.5%) (p=0.012).
  • CONCLUSION: The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE E3/E4 genotype have lower risk suffering from colorectal adenomas than those with other genotypes.
  • [MeSH-major] Adenoma / blood. Adenoma / genetics. Apolipoproteins E / genetics. Colorectal Neoplasms / blood. Colorectal Neoplasms / genetics. Lipids / blood

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  • (PMID = 16501668.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Cholesterol, HDL; 0 / Cholesterol, LDL; 0 / Lipids; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
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36. Husillos Alonso A, Subirá Ríos D, Molina Escudero R, Hernández Fernández C: Villous adenoma in augmentation colocystoplasty asociated to infiltrating urotelial cancer in bladder remanent. Arch Esp Urol; 2010 Dec;63(10):876-9
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  • [Title] Villous adenoma in augmentation colocystoplasty asociated to infiltrating urotelial cancer in bladder remanent.
  • OBJECTIVE: To report a new case of villous adenoma developed in augmentation colocystoplasty.
  • RESULTS: We report the case of a 66 year-old man with a villous adenoma and synchronic infiltrating transitional cell carcinoma of the bladder after augmentation colocystoplasty.
  • The latency period until the development of villous adenoma after surgery is long.
  • CONCLUSIONS: Villous adenoma is a benign neoplasm that occurs in the colonic mucosa and shows a high ability to become a malignant colonic cancer.
  • Only two cases of villous adenoma in augmentation colocystoplasty have been reported.
  • [MeSH-major] Adenoma, Villous / etiology. Carcinoma, Transitional Cell / etiology. Neoplasms, Multiple Primary / etiology. Urinary Bladder Neoplasms / etiology. Urinary Reservoirs, Continent / adverse effects

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  • (PMID = 21187572.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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37. Shih CM, Wu SC, Lee CC, Pan CC: Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis. J Chin Med Assoc; 2007 Jan;70(1):33-5

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  • [Title] Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis.
  • Villous adenoma is most frequently found in the colon and rectum, seldom in the urinary tract and even more rarely in the ureter or pelvis.
  • The ureteral tumor proved to be villous adenoma by pathologic examination.
  • It should be noted that ureteral villous adenoma may be related to previous enteric-type metaplastic mucosa or ureteritis glandularis, demonstrates profuse production of mucus, and may eventually undergo malignant transformation.
  • [MeSH-major] Adenoma, Villous / complications. Hydronephrosis / etiology. Ureteral Neoplasms / complications

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  • (PMID = 17276931.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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38. Sun JH, Chao M, Zhang SZ, Zhang GQ, Li B, Wu JJ: Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater. World J Gastroenterol; 2008 Aug 7;14(29):4709-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater.
  • The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma.
  • We herein describe an unusual case of a small cell neuroendocrine carcinoma associated with a villous adenoma in the ampulla of Vater with emphasis on computed tomography (CT) and histopathological findings.
  • [MeSH-major] Adenoma, Villous / complications. Ampulla of Vater. Carcinoma, Neuroendocrine / complications. Common Bile Duct Neoplasms / complications

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  • [Cites] Hepatogastroenterology. 2001 Nov-Dec;48(42):1588-93 [11813580.001]
  • [Cites] Gastrointest Endosc. 2002 Jun;55(7):870-6 [12024143.001]
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  • (PMID = 18698690.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738800
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39. Xu HX, Chen LD: Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings. J Clin Ultrasound; 2008 Jan;36(1):39-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings.
  • We report a case of villous adenoma in the extrahepatic bile duct that was successfully diagnosed with contrast-enhanced sonography (CEUS) before surgical resection.
  • Surgical resection was performed, and pathologic examination confirmed a villous adenoma of the bile duct epithelium with mild dysplasia.
  • [MeSH-major] Adenoma, Villous / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Extrahepatic / ultrasonography

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17565756.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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40. Gimeno-García AZ, Ramírez F, Gonzalo V, Balaguer F, Petit A, Pellisé M, Llach J, Bordas JM, Piqué JM, Castells A: [High-grade dysplasia as a risk factor of metachronous advanced colorectal neoplasms in patients with advanced adenomas]. Gastroenterol Hepatol; 2007 Apr;30(4):207-11
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  • [Title] [High-grade dysplasia as a risk factor of metachronous advanced colorectal neoplasms in patients with advanced adenomas].
  • [Transliterated title] Displasia de alto grado como factor de riesgo de neoplasia colorrectal avanzada metacrónica, en pacientes con adenomas avanzados.
  • BACKGROUND: Patients with advanced adenomas (AA) have a high risk of developing advanced colorectal neoplasms.
  • However, its predictive value for developing advanced neoplams in patients with advanced adenoma is unknown.
  • Patients with a history of colorectal cancer (CRC), inflammatory bowel disease, familial adenomatous polyposis or patients who met the Amsterdam criteria, and those without colonoscopic monitoring were excluded.
  • The number of metachronic polyps (p = 0.67), adenomas (p = 0.73), AA (p = 0.93) and AA with HGD (p = 0.88) was also similar.
  • CONCLUSION: The risk of developing advanced neoplasms is not different between AA with HGD and those with other characteristics of AA (villous pattern and larger than 1 cm).
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Colonic Polyps / pathology. Colonoscopy / methods. Colorectal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Male. Middle Aged. Risk Factors. Time Factors

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  • (PMID = 17408548.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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41. Joniau S, Lerut E, Van Poppel H: A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature. Case Rep Med; 2009;2009:818646
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature.
  • We present an exceptional case of a giant urachal tumor, consisting of both villous adenoma and mucinous adenocarcinoma of the urachus.
  • Initial transurethral biopsies showed only a villous adenoma of the urachus.
  • The patient remained free of disease for 50 months of follow-up.
  • Only three previous cases of urachal adenocarcinoma associated with villous adenoma have been described.

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  • [Cites] J Urol. 1978 Feb;119(2):287-8 [633500.001]
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  • (PMID = 20182635.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2825668
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42. Perçinel S, Savaş B, Ensari A, Kuzu I, Kuzu MA, Bektaş M, Cetinkaya H, Kurşun N: Mucins in the colorectal neoplastic spectrum with reference to conventional and serrated adenomas. Turk J Gastroenterol; 2007 Dec;18(4):230-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucins in the colorectal neoplastic spectrum with reference to conventional and serrated adenomas.
  • BACKGROUND/AIMS: Alterations in expression of mucins and aberrant expression of various types of mucin genes were observed in colorectal adenomas and carcinomas, though their significance in neoplastic transformation of colorectal epithelium is yet to be determined.
  • The aim of this study was to determine expression of MUC1, MUC2, MUC5AC, and MUC6 through conventional adenoma-carcinoma sequence and polyps involved in the "serrated" pathway of the colorectum using tissue array technique.
  • METHODS: In this study, a total of 172 cases including 100 colorectal polyps [8 hyperplastic polyps, 10 sessile serrated adenomas, 19 tubular, 37 tubulovillous, and 26 villous adenomas], 16 adenomas with intramucosal carcinoma, 28 conventional colorectal cancers, and 28 normal mucosae were examined.
  • Sessile serrated adenomas exhibited the highest MUC5AC expression while adenomatous polyps showed an increase in MUC5AC expression in parallel with neoplastic progression (p<0.001).
  • Hyperplastic polyps seemed to lie between normal mucosa and sessile serrated adenomas in terms of mucin expression, suggesting that they are morphologically and histogenetically linked.
  • CONCLUSIONS: Upregulation of MUC1 and MUC6 through the adenoma-carcinoma sequence together with downregulation of MUC2 and MUC5AC at the neoplastic end of the spectrum seem to follow the steps of malignant transformation.
  • [MeSH-major] Adenoma / metabolism. Colonic Polyps / metabolism. Colorectal Neoplasms / metabolism. Mucins / metabolism

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  • (PMID = 18080919.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Mucins
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43. Kaczka A, Kumor A, Pietruczuk M, Małecka-Panas E: [Serum concentration of insulin, C-peptide and insulin-like growth factor I in patients with colon adenomas and colorectal cancer]. Pol Merkur Lekarski; 2007 May;22(131):373-5
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  • [Title] [Serum concentration of insulin, C-peptide and insulin-like growth factor I in patients with colon adenomas and colorectal cancer].
  • The aim of the study was to evaluate the serum concentration of insulin, C-peptide and IGF-I in patients with colon adenomas and colorectal cancer.
  • MATERIALS AND METHODS: In 17 patients with colon cancer, 32 patients with colon adenomas and in 12 healthy persons the serum concentration of insulin, C-peptide and IGF-I was determined using ELISA kits.
  • In patients with colon adenomatous polyps we also observed higher serum IGF-I concentrations I comparing to the control group (82.1 ng/ml vs. 60.96 ng/ml), in high dysplasia adenomas (84.12 ng/ml vs. 79.67 ng/ml) and in smaller adenomas to 1 cm diameter (97.98 ng/ml vs. 73.28 ng/ml), but the differences were not significant.
  • We also observed higher concentration of C-peptide in patients with low grade dysplasia adenomas (665.24 pmol/l vs. 498.13 pmol/l) and with small polyps (611.51 pmol/l vs. 514.89 pmol/l).
  • There were no differences in serum concentration of IGF-I and C-peptide between patients with tubular and villous adenomas.
  • [MeSH-major] Adenoma / blood. Adenomatous Polyps / blood. C-Peptide / blood. Colonic Polyps / blood. Colorectal Neoplasms / blood. Insulin / blood

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  • (PMID = 17679371.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / C-Peptide; 0 / Insulin; 67763-96-6 / Insulin-Like Growth Factor I
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44. Genc H, Haciyanli M, Tavusbay C, Colakoglu O, Aksöz K, Unsal B, Ekinci N: Carcinoma arising from villous adenoma of the ampullary bile duct: Report of a case. Surg Today; 2007;37(2):165-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma arising from villous adenoma of the ampullary bile duct: Report of a case.
  • Adenocarcinoma arising from the villous adenoma of the ampullary biliary epithelium is an extremely rare disorder.
  • The preoperative diagnosis and treatment of the disease represent a major difficulty.
  • A frozen-section examination of these particles revealed villous adenoma.
  • The frozen-section examination of the resected material also revealed a villous adenoma.
  • The histological examination revealed a villous adenoma arising from the biliary epithelium and some adenocarcinoma foci.
  • This case shows the importance of surgeons to keep in mind the fact that frozen examinations may sometimes miss a malignancy and they therefore cannot be relied upon to rule out malignancy in villous adenoma of the ampullary bile duct.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary

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  • (PMID = 17243040.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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45. Giuliani A, Caporale A, Corona M, Ricciardulli T, Di Bari M, Demoro M, Scarpini M, Angelico F: Large size, villous content and distal location are associated with severe dysplasia in colorectal adenomas. Anticancer Res; 2006 Sep-Oct;26(5B):3717-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large size, villous content and distal location are associated with severe dysplasia in colorectal adenomas.
  • The risk of cancer development has been associated with age and size, amount of villous component and high-grade dysplasia of adenomas.
  • The subject-related and adenoma-related risk factors for severely dysplastic lesions were further investigated.
  • Adenomas synchronous with hyperplastic polyps of larger diameter (>10 mm) showed an increased risk of severe dysplasia (OR = 6.94).
  • Severe dysplasia occurred more significantly in younger subjects harbouring villous growths (OR = 4.28, p < 0.03) and in larger adenomas (OR = 3.91, p < 0.001).
  • The risk for severe dysplasia in relation to gender, age, multiplicity and location was higher in adenomas of larger diameter and with villous content.
  • Multivariate analysis showed that distal site (p < 0.02), large size (p < 0.001) and villous content (p < 0.001) were the independent risk factors for severe dysplasia.
  • CONCLUSION: Large size, villous content and distal location are associated with severe dysplasia in colorectal adenomas.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17094390.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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46. Piana S, Asioli S, Foroni M: Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. Virchows Arch; 2006 Feb;448(2):228-31
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  • [Title] Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features.
  • We describe a case of oncocytic adenocarcinoma of the rectum, associated with a villous adenoma, arising on a 66-year-old man.
  • Superficially, a villous adenoma with high-grade dysplasia was evident; adenomatous cells showed focal eosinophilic changes, consisting of a large granular cytoplasm, an oval atypical nucleus, and a prominent nucleolus.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16450120.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Carcinoembryonic Antigen; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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47. de Decker S, Bovy C, Deflandre J, Moonen M, Van Nes MC: Treatment of a nephrotic syndrome by endoscopic removal of a villous adenoma of the duodenum. Gastroenterol Clin Biol; 2010 Nov;34(11):625-8
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  • [Title] Treatment of a nephrotic syndrome by endoscopic removal of a villous adenoma of the duodenum.
  • We report the case of a patient diagnosed with a villous adenoma of the duodenum showing high degree dysplasia who developed a nephrotic syndrome (NS) due to a membranous nephropathy (MN), demonstrated by renal biopsy.
  • Only the endoscopic resection of the duodenal adenoma could control the NS.
  • [MeSH-major] Adenoma, Villous / surgery. Duodenal Neoplasms / surgery. Duodenoscopy. Nephrotic Syndrome / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20850233.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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48. Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK: Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis. Dis Colon Rectum; 2005 Apr;48(4):816-23
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  • [Title] Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis.
  • Our aim was to evaluate prospectively the prevalence, nature, and etiology of pouch ileal adenomas with that of nonpouch ileal adenomas in familial adenomatous polyposis.
  • A logistic regression model confirmed that there was a significant association between the increasing age of the patient and the presence of pouch adenomas (P < 0.02) and the length of follow-up since pouch surgery (P < 0.05).
  • There was no apparent relationship between the development of pouch adenomas and the severity of either colonic or duodenal polyposis and there were no clear genotype or phenotype correlations.
  • Most polyps were tubular adenomas with mild dysplasia, but 11 patients had more advanced histology, including two patients with large villous adenomas.
  • Nonpouch ileal mucosa was spared from visually observed adenomas, with only 1 of 48 (2 percent) patients with ileorectal anastomosis adenomas and 0 of 20 (0 percent) younger, precolectomy patients having terminal ileal adenomas.
  • Long-term endoscopic surveillance of familial adenomatous polyposis pouches is thus recommended along with evaluation of potential therapeutic options for pouch adenomas.
  • [MeSH-major] Adenoma / epidemiology. Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / surgery. Colonic Pouches / pathology. Ileal Neoplasms / epidemiology. Proctocolectomy, Restorative

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  • (PMID = 15747076.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Lee SE, Park NH, Park IA, Kang SB, Lee HP: Tubulo-villous adenoma of the vagina. Gynecol Oncol; 2005 Feb;96(2):556-8
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  • [Title] Tubulo-villous adenoma of the vagina.
  • BACKGROUND: Tubulo-villous adenomas are common in the colon and rectum, but extremely rare in the vagina.
  • As far as we know, only two cases of tubulo-villous adenoma have ever been reported.
  • We report the third case of enteric-type tubulo-villous adenoma of the vagina.
  • The tumor was excised and pathologically confirmed as a tubulo-villous adenoma.
  • CONCLUSION: Because some tubulo-villous adenomas in the colon and rectum can progress to the cancer, this case requires long-term follow-up to detect recurrence and malignant transformation.
  • [MeSH-major] Adenoma, Villous / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 15661252.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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50. Akaydin M, Ersoy YE, Erozgen F, Ferlengez E, Kaplan R, Celik A, Memmi N: Tubulovillous adenoma in the common bile duct causing obstructive jaundice. Acta Gastroenterol Belg; 2009 Oct-Dec;72(4):450-4

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  • [Title] Tubulovillous adenoma in the common bile duct causing obstructive jaundice.
  • Villous adenomas are benign epithelial lesions with a malignant potential which can occur at any site in the gastrointestinal tract, usually in the rectum and colon, less frequently in the small bowel and very rarely in the biliary tract.
  • Villous adenomas of the extrahepatic bile ducts are exceptional and only a few cases have been reported.
  • Common bile duct (CBD) adenomas often present in a fashion similar to their malignant counterparts, and adenocarcinoma arising from a villous adenoma of the ampullary biliary epithelium is also extremely rare.
  • We present here a tubulovillous adenoma, arising in the common bile duct, as a cause of obstructive jaundice, and discuss the characteristics of these lesions.
  • [MeSH-major] Adenoma, Villous / complications. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology

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  • (PMID = 20163042.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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51. Bhat S, Chandran V: Villous adenoma of the renal pelvis and ureter. Indian J Urol; 2010 Oct;26(4):598-9

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  • [Title] Villous adenoma of the renal pelvis and ureter.
  • Villous adenoma originating in the urinary tract is a rare condition.
  • We are reporting the third case of muconephrosis due to villous adenomatous changes of the renal pelvis and ureter.

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  • [Cites] Am J Surg Pathol. 1999 Jul;23(7):764-71 [10403298.001]
  • [Cites] Urology. 2002 Aug;60(2):344 [12137843.001]
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  • (PMID = 21369402.001).
  • [ISSN] 1998-3824
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3034078
  • [Keywords] NOTNLM ; Muconephrosis / villous adenoma
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52. Alexander CL, Urbanski SJ, Hilsden R, Rabin H, MacNaughton WK, Beck PL: The risk of gastrointestinal malignancies in cystic fibrosis: case report of a patient with a near obstructing villous adenoma found on colon cancer screening and Barrett's esophagus. J Cyst Fibros; 2008 Jan;7(1):1-6
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  • [Title] The risk of gastrointestinal malignancies in cystic fibrosis: case report of a patient with a near obstructing villous adenoma found on colon cancer screening and Barrett's esophagus.
  • We present a 39 year old male CF patient that underwent a colonoscopy for colon cancer screening and a large, near obstructing, villous adenoma of his ileum was found.
  • [MeSH-major] Adenoma, Villous / complications. Barrett Esophagus / complications. Cystic Fibrosis / complications. Ileal Neoplasms / complications
  • [MeSH-minor] Adult. Colonoscopy. Endoscopy, Gastrointestinal. Genetic Predisposition to Disease. Humans. Male. Risk Factors


53. Jass JR, Baker K, Zlobec I, Higuchi T, Barker M, Buchanan D, Young J: Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. Histopathology; 2006 Aug;49(2):121-31
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  • [Title] Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer.
  • METHODS AND RESULTS: Thirty-two sessile serrated adenomas (SSA), 10 mixed polyps (MP), 15 traditional serrated adenomas (SA), 49 hyperplastic polyps (HP) and 84 adenomas were assessed for mutation of KRAS and BRAF and aberrant expression of p53.
  • KRAS mutation occurred more frequently (26.5%) than BRAF mutation (4.8%) in adenomas (P < 0.001) and particularly in adenomas with villous architecture (50%).
  • Loss of expression of MGMT correlated with KRAS mutation in small tubular adenomas (P < 0.04).
  • Aberrant expression of p53 was uncommon overall, but occurred more frequently in MPs and SAs (12%) than adenomas (1%) (P < 0.04) and there was concordant loss of expression of MGMT.
  • CONCLUSIONS: Molecular alterations that are characteristic of the serrated pathway and adenoma-carcinoma sequence can co-occur in a minority of advanced colorectal polyps that then show morphological features of both pathways.
  • [MeSH-minor] Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. DNA Mutational Analysis. Humans. Immunohistochemistry. O(6)-Methylguanine-DNA Methyltransferase / metabolism. Tumor Suppressor Protein p53 / metabolism


54. Macher-Goeppinger S, Aulmann S, Haferkamp A, Hohenfellner M, Schirmacher P, Bläker H: [Villous adenoma within an urachal diverticulum associated with long-term mucusuria]. Pathologe; 2008 Jul;29(4):305-7

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  • [Title] [Villous adenoma within an urachal diverticulum associated with long-term mucusuria].
  • After surgical resection histologic examination showed a mucus producing, intestinally differentiated adenoma within the diverticulum.
  • This finding explains both the recurrent infections and the 10-year history of mucusuria.

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  • (PMID = 18274750.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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55. Mattar W, Rex DK: Large sessile adenomas are associated with a high prevalence of synchronous advanced adenomas. Clin Gastroenterol Hepatol; 2008 Aug;6(8):877-9
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  • [Title] Large sessile adenomas are associated with a high prevalence of synchronous advanced adenomas.
  • BACKGROUND & AIMS: The prevalence of synchronous neoplasia in patients with large sessile colorectal adenomas is uncertain.
  • METHODS: We conducted a retrospective single-center review of synchronous neoplastic findings in 190 consecutive patients with intact colons and single large sessile adenomas resected endoscopically.
  • Synchronous polyps were those removed at the colonoscopy that discovered the large sessile adenoma or at any follow-up endoscopic examination within 12 months of discovery of the large sessile adenoma.
  • RESULTS: Seventy-five percent of patients had at least 1 synchronous adenoma, and the 190 patients had a mean of 4 synchronous adenomas.
  • Thirty percent of patients had > or =1 synchronous advanced adenoma (adenoma > or =1 cm in size or with high-grade dysplasia or villous elements).
  • There were a total of 116 synchronous advanced adenomas, including 89 adenomas 10-19 mm in size and 8 that were > or =20 mm in size.
  • CONCLUSIONS: Colonoscopists should be aware that patients with large sessile adenomas have a high prevalence of synchronous advanced neoplasia.
  • [MeSH-major] Adenoma / epidemiology. Adenoma / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18585969.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Mila R, Grille S, Laurini M, Lapiedra D, Bagattini JC: [McKittrick- Wheelock syndrome: report of one case]. Rev Med Chil; 2008 Jul;136(7):900-4
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  • Villous colorectal adenomas are common tumors that normally provoke scarce symptomatology.
  • Colonoscopy confirmed the presence of a villous adenoma that was excised surgically.
  • In this patient, the fluid and electrolyte hypersecretion of the rectal villous adenoma provoked a depletion syndrome with serious hydroelectrolytic alterations, acute renal failure and hypovolemic shock.
  • [MeSH-major] Adenoma, Villous / complications. Colonic Neoplasms / complications. Water-Electrolyte Imbalance / etiology

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  • (PMID = 18949168.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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57. Barry EL, Baron JA, Grau MV, Wallace K, Haile RW: K-ras mutations in incident sporadic colorectal adenomas. Cancer; 2006 Mar 1;106(5):1036-40
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  • [Title] K-ras mutations in incident sporadic colorectal adenomas.
  • In the current study, the authors investigated associations with K-ras mutation in incident sporadic colorectal adenomas that occurred during a chemoprevention trial of calcium supplementation.
  • METHODS: K-ras genotyping was performed on 303 colorectal adenomas that were removed from 207 participants during the follow-up phase of the Calcium Polyp Prevention Study.
  • RESULTS: The adenomas analyzed had a mean estimated size of 0.5 cm, and 3.0% were identified with mutations (95% confidence interval [95% CI], 1.3-4.4%).
  • These mutations were more common in larger adenomas (risk ratio [RR], 12.7 for tumors that measured > 0.5 cm vs. < or = 0.5 cm; 95% CI, 2.7-59.7), in adenomas with more advanced histology (RR, 20.6 for tubulovillous/villous vs. tubular; 95% CI, 4.4-96.0), and in adenomas that were located in the rectum compared with the colon (RR, 8.4; 95% CI, 2.3-30.5).
  • CONCLUSIONS: Compared with previous studies, the current analysis was novel, because it focused on incident adenomas that were diagnosed within a few years of a previous "clean" colonoscopy.
  • The results provided evidence for a very low rate of K-ras mutation among these small, early adenomas and strong support for a role of K-ras mutations in adenoma progression.

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  • (PMID = 16456810.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA046927; United States / NCI NIH HHS / CA / CA-046927
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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58. Gracia Solanas JA, Ramírez Rodríguez JM, Aguilella Diago V, Elía Guedea M, Martínez Díez M: A prospective study about functional and anatomic consequences of transanal endoscopic microsurgery. Rev Esp Enferm Dig; 2006 Apr;98(4):234-40
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  • INTRODUCTION: transanal endoscopic microsurgery (TEM) was developed in 1983 by Büess as a minimally invasive technique to manage rectal villous adenomas and early rectal adenocarcinomas.
  • RESULTS: 32 patients (80%) had villous adenomas and 8 patients (20%) had adenocarcinomas (uT1).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Microsurgery / methods. Proctoscopy. Rectal Neoplasms / surgery

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  • (PMID = 16792452.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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59. Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland CR: Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps. Cancer Epidemiol Biomarkers Prev; 2005 Sep;14(9):2253-6
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  • [Title] Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps.
  • BACKGROUND: Serrated adenomas are characterized by serrated crypts with dysplasia, and are distinguished from other polyps by their histology, but the genetic basis of serrated adenomas is unknown.
  • We investigated genetic alterations in colorectal polyps to determine if a specific pattern were associated with serrated adenomas.
  • METHODS: Sixty-six small (<10 mm) colorectal polyps were studied, including 11 hyperplastic polyps, 27 serrated adenomas, 9 tubular adenomas, 6 tubulovillous adenomas, and 3 villous adenomas.
  • Allelic imbalance of 18q was significantly more common (P < 0.05), whereas allelic imbalance of 5q and K-ras mutations were significantly less common (P < 0.05) in serrated adenomas compared with other polyps.
  • CONCLUSIONS: Serrated adenomas are significantly more likely to have allelic imbalance at 18q than other types of adenomas, and significantly less likely to have allelic imbalance at 5q or K-ras mutations.
  • Serrated adenomas seem to evolve through a different genetic pathway than other types of polyps in the colon.

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  • (PMID = 16172239.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090231-05; United States / NCI NIH HHS / CA / R01 CA090231; United States / NCI NIH HHS / CA / R-01 CA72851; United States / NCI NIH HHS / CA / R01 CA090231-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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60. Wang LP, Chen J, Ning HY, Zhang XZ, Cheng J, Li L, Wang B, Dai XJ, Zhu HY, Miao JH, Wang L: [Serrated lesions of colon and their malignant potential]. Zhonghua Bing Li Xue Za Zhi; 2010 Jul;39(7):447-51
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  • OBJECTIVE: To study the serrated lesions of colon and to compare the malignant potential between traditional serrated adenomas (TSA) and conventional adenomas (CAD).
  • One hundred and eighty-seven cases of CAD (including 160 cases of tubular adenoma and 27 cases of villous adenoma) and 36 cases of invasive adenocarcinoma were randomly selected as the controls.
  • RESULTS: Amongst the 5347 colorectal polyps studied, 258 cases (4.8%) of serrated lesions were found, which included 112 cases (43.4%, 112/258) of hyperplastic polyp, 78 cases (30.2%, 78/258) of TSA and 26 cases (10.1%, 26/258) of sessile serrated adenoma.
  • [MeSH-major] Adenoma / pathology. Cell Transformation, Neoplastic / pathology. Colorectal Neoplasms / pathology. Intestinal Polyps / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma, Villous / classification. Adenoma, Villous / metabolism. Adenoma, Villous / pathology. Colonic Polyps / metabolism. Colonic Polyps / pathology. Humans. Ki-67 Antigen / metabolism. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Rectum / pathology. Retrospective Studies. Tumor Suppressor Protein p53 / metabolism. beta Catenin / metabolism

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  • (PMID = 21055172.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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61. Khvatov AA, Borisov AE, Sherstnova EM, Miaukina LM: [Experience with treatment of patients with villous adenoma of the large intestine]. Vestn Khir Im I I Grek; 2010;169(4):78-9

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  • [Title] [Experience with treatment of patients with villous adenoma of the large intestine].
  • [MeSH-major] Adenoma, Villous / surgery. Colonic Neoplasms / surgery

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  • (PMID = 20973193.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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62. Dhamanaskar KP, Thurston W, Wilson SR: Transvaginal sonography as an adjunct to endorectal sonography in the staging of rectal cancer in women. AJR Am J Roentgenol; 2006 Jul;187(1):90-8
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  • Forty-nine of the women had rectal carcinoma; nine, tubulovillous adenoma; and two, gastrointestinal stromal tumor confirmed at surgical pathologic examination (n = 41) and biopsy before chemoradiation therapy (n = 19).
  • Four of the nine villous adenomas were overstaged as T1 on Tvs. Gastrointestinal stromal tumors manifested as intramural vascular masses.
  • [MeSH-minor] Adenoma, Villous / pathology. Adenoma, Villous / ultrasonography. Aged. Carcinoma / pathology. Carcinoma / ultrasonography. Female. Humans. Middle Aged. Sensitivity and Specificity. Vagina

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  • (PMID = 16794161.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Yoo TW, Park DI, Kim YH, Kim HS, Kim WH, Kim TI, Kim HJ, Yang SK, Byeon JS, Lee MS, Jung IK, Chung MK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS, Song JS: Clinical significance of small colorectal adenoma less than 10 mm: the KASID study. Hepatogastroenterology; 2007 Mar;54(74):418-21
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  • [Title] Clinical significance of small colorectal adenoma less than 10 mm: the KASID study.
  • BACKGROUND/AIMS: Polypectomy is the current modality of choice to prevent benign colorectal adenoma from progressing to an invasive cancer.
  • However, in cases of small colorectal adenoma, it remains unclear as to whether polypectomy is actually an effective treatment modality.
  • We evaluated the clinical significance of polypectomy in cases of small colorectal adenomas, measuring less than 10 mm.
  • A total of 5996 colorectal adenomas were detected and divided into 5 groups according to their size (Group 1; 1-5 mm, Group 2; 6-7 mm, Group 3; 8-9 mm, Group 4; 10-19 mm, Group 5; more than 20 mm).
  • The term 'advanced adenoma' refers here to tubular adenomas with diameters of at least 10 mm, or to tubulovillous, villous, or high-grade dysplasia, irrespective of size.
  • RESULTS: As the sizes of the adenomas increased, the prevalence of advanced adenoma was also observed to increase.
  • In Groups 2 and 3, the prevalence of tubulovillous or villous adenoma were higher than was expected (5.2% and 6.6%, p < 0.001).
  • CONCLUSIONS: In cases of small colorectal adenomas, measuring between 6 and 9 mm, the prevalence of cancer was at least as high as that seen in the cases of colorectal adenomas measuring between 10 and 19 mm.
  • Therefore, small colorectal adenomas measuring between 6 and 9 mm should not be ignored, in order to decrease the prevalence of colorectal cancer.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / pathology. Adenoma, Villous / surgery. Adult. Aged. Cell Transformation, Neoplastic / pathology. Cohort Studies. Colonoscopy. Female. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Male. Middle Aged. Risk Factors

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  • (PMID = 17523287.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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64. Saini SD, Kim HM, Schoenfeld P: Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review. Gastrointest Endosc; 2006 Oct;64(4):614-26
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  • [Title] Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review.
  • BACKGROUND: Current guidelines stratify patients with a personal history of adenomas as low risk (ie, 1-2 small [<10 mm] adenomas at index colonoscopy) or high risk (> or =3 small adenomas or advanced adenoma at index colonoscopy) for recurrent advanced adenomas.
  • OBJECTIVE: Our purpose was to perform a meta-analysis about the incidence of advanced adenomas at 3-year surveillance colonoscopy among high- and low-risk patients.
  • Study selection criteria were (1) study design--prospective or registry-based study, (2) study population--patients with a personal history of adenomas, and (3) intervention--completion of surveillance colonoscopy at an interval of > or =2 years.
  • Data were extracted on (1) incidence of advanced adenomas at surveillance colonoscopy, (2) interval between colonoscopies, and (3) risk factors associated with recurrent adenomas.
  • After the validity of study design was assessed and independent, duplicate data extraction was performed from selected trials, summary relative risks (RR) for the incidence of advanced adenomas at 3-year colonoscopy were calculated.
  • Patients with > or =3 adenomas at index colonoscopy were more likely to have recurrent advanced adenomas than were patients with 1 to 2 adenomas: RR 2.52, 95% CI 1.07-5.97.
  • Patients with adenomas with high-grade dysplasia at index colonoscopy were also at increased risk for recurrent advanced adenomas: RR 1.84, 95% CI 1.06-3.19.
  • In the individual studies, increasing size of adenomas and increasing number of adenomas at index colonoscopy were the most commonly reported risk factors associated with recurrent advanced adenomas.
  • CONCLUSION: Few published studies stratify the incidence of advanced adenomas at surveillance colonoscopy according to index colonoscopy findings.
  • In the future, large prospective studies or studies using pooled data from existing randomized controlled trial databases or polyp registries should be used to better define which patients are at low risk for advanced adenoma recurrence.
  • [MeSH-major] Adenoma / epidemiology. Adenoma / pathology. Adenomatous Polyps / epidemiology. Adenomatous Polyps / pathology. Colonic Neoplasms / epidemiology. Colonic Neoplasms / pathology. Colonoscopy. Mass Screening. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / pathology. Rectal Neoplasms / epidemiology. Rectal Neoplasms / pathology
  • [MeSH-minor] Adenoma, Villous / epidemiology. Adenoma, Villous / pathology. Cell Transformation, Neoplastic / pathology. Evidence-Based Medicine. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Population Surveillance. Practice Guidelines as Topic. Prospective Studies. Randomized Controlled Trials as Topic. Risk Factors

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  • (PMID = 16996358.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K23DK060040-03
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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65. Katsinelos P, Basdanis G, Chatzimavroudis G, Karagiannoulou G, Katsinelos T, Paroutoglou G, Papaziogas B, Paraskevas G: Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. World J Gastroenterol; 2006 Aug 14;12(30):4927-9
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  • [Title] Pancreatitis complicating mucin-hypersecreting common bile duct adenoma.
  • Villous adenomas of the bile ducts are extremely uncommon.
  • He underwent a modified Whipple operation and histological examination of the surgical specimen showed villous adenoma with rich secretion of mucus.
  • [MeSH-major] Adenoma, Bile Duct / complications. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Mucins / secretion. Pancreatitis / etiology

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  • (PMID = 16937485.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucins
  • [Other-IDs] NLM/ PMC4087637
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66. Selcuk H, Korkmaz M, Kanbay M, Tore E, Sumer H, Unal H, Yeloglu O, Gur G, Bilezikci B, Demirhan B, Yilmaz U, Boyacioglu S: Total colonic polyp diameter: a marker for the risk of malignancy? Hepatogastroenterology; 2008 May-Jun;55(84):936-9
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  • The polyps were further categorized by histopathologic component as "unfavorable" or "favorable" and were divided into 2 groups: group 1 (those identified as carci noma, carcinoma in situ, villous adenoma, and tubulovillous adenoma with a villous component of more than 25%) and group 2 (mixed adenomatous polyps with various degrees of hyperplastic or inflammatory components and adenomas with a tubular component of more than 75%).
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Adenomatous Polyps / pathology. Adult. Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Colonoscopy. Female. Humans. Male. Middle Aged. Prognosis. Risk Factors

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  • (PMID = 18705301.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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67. Apel D, Jakobs R, Spiethoff A, Riemann JF: Follow-up after endoscopic snare resection of duodenal adenomas. Endoscopy; 2005 May;37(5):444-8
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  • [Title] Follow-up after endoscopic snare resection of duodenal adenomas.
  • The aim of this study was to determine the long-term outcome after endoscopic resection of duodenal adenomas.
  • PATIENTS AND METHODS: Between January 1990 and April 2003 we retrospectively evaluated a group of patients who presented with nonampullary duodenal villous tumors but who did not have a polyposis syndrome.
  • Of these, 18 patients (6 men, 12 women; median age 67, range 50 - 81), with a total of 20 duodenal adenomas, were enrolled into the study.
  • Of these 20 tumors, 18 adenomas were tubulovillous, one was tubulous and one was villous.
  • Nineteen polyps were treated by snare excision and one adenoma was treated with argon plasma coagulation alone.
  • The success rate for endoscopic adenoma removal after a 3-month interval was 55 %.
  • CONCLUSIONS: Endoscopic snare excision of duodenal adenomas is an effective mode of treatment but an endoscopic surveillance program is mandatory in order to detect and treat recurrence.
  • [MeSH-major] Adenoma / surgery. Duodenal Neoplasms / surgery. Duodenoscopy. Neoplasm Recurrence, Local / surgery

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  • (PMID = 15844023.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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68. Ravizza D, Bartolomei M, Santoro L, Tamayo D, Fiori G, Trovato C, De Cicco C, De Roberto G, Paganelli G, Crosta C: Positron emission tomography for the detection of colorectal adenomas. Dig Liver Dis; 2010 Mar;42(3):185-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Positron emission tomography for the detection of colorectal adenomas.
  • BACKGROUND: (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) has been reported to detect colorectal adenomas.
  • AIMS: This study aimed at evaluating the sensitivity of (18)F-FDG PET with computed tomography image fusion (PET/CT) for detecting colorectal adenomas.
  • All the 12 malignancies were identified by (18)F-FDG PET/CT but only 27 out of 119 resected adenomas (sensitivity 22.7%) and none of the hyperplastic polyps were detected.
  • At the univariate and multivariate analyses there was a significant statistical association between adenomas sized more than 10mm, presence of villous component and high-grade dysplasia and the ability of (18)F-FDG PET/CT to detect adenomas. (18)F-FDG PET/CT showed an overall sensitivity of 29.8%, a specificity of 81.1%, a positive predictive value (PPV) of 84.8% and a negative predictive value (NPV) of 24.6% for the neoplastic colorectal lesions globally considered.
  • CONCLUSION: (18)F-FDG PET/CT has a low sensitivity for detecting adenomas.
  • [MeSH-major] Adenoma / radionuclide imaging. Colorectal Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18. Positron-Emission Tomography

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  • [Copyright] 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19643688.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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69. Wasilewicz MP, Kołodziej B, Bojułko T, Kaczmarczyk M, Sulzyc-Bielicka V, Bielicki D, Ciepiela K: Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis. Int J Colorectal Dis; 2010 Sep;25(9):1079-85
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  • [Title] Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
  • Our purpose was to investigate the possible connection between 5-LOX expression and colon carcinogenesis by characterizing 5-LOX expression in histologically different colonic adenomas, determining the relationship between high expression of 5-LOX and various conventional clinicopathological features of adenomas, and finally characterizing the histological localization of cells with 5-LOX overexpression.
  • METHODS: A total of 111 patients were examined and 120 histologically different colonic adenomas analyzed (including four cases of intramucosal adenocarcinoma in a polyp).
  • RESULTS: There was a significant correlation between high 5-LOX expression and patient age, increased polyp size, high grade of intraepithelial neoplasia, villous and tubulovillous adenoma, and histological epithelial localization.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Arachidonate 5-Lipoxygenase / metabolism. Colonic Neoplasms / enzymology. Colonic Neoplasms / pathology. Precancerous Conditions / enzymology. Precancerous Conditions / pathology

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  • (PMID = 20549218.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
  • [Other-IDs] NLM/ PMC2912725
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70. Colović R, Grubor N, Micev M, Ugljesić M, Latincić S: [Villous duodenal adenoma with II and III grade dysplasia and carcinoma in situ treated with cephalic duodenopancreatectomy]. Vojnosanit Pregl; 2006 Dec;63(12):1045-8
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  • [Title] [Villous duodenal adenoma with II and III grade dysplasia and carcinoma in situ treated with cephalic duodenopancreatectomy].
  • BACKGROUND: Villous duodenal adenomas are rare, tend to malignant alteration and recurrency if surgical procedures are not sufficiently radical.
  • CASE REPORT: In this paper we presented a 79-year-old female patient already operated on twice elsewhere due to obstructive jaundice caused by villous duodenal adenoma, using, firstly, cholecystectomy and T-tube drainage of the choledoclus, and, then, an unsuccessful attempt of radical surgery--duodenopancreatectomy.
  • Histology confirmed villous duodenal adenomas with II and III grade dysplasia and carcinoma in situ.
  • CONCLUSION: Villous duodenal adenoma is curable if treated correctly and in a proper time.
  • [MeSH-major] Adenoma, Villous / pathology. Carcinoma in Situ / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreaticoduodenectomy

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  • (PMID = 17252711.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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71. Kristjansdottir S, Jonasson JG, Cariglia N, Thjodleifsson B: Colonic adenomas found via colonoscopy: yield and risk factors for high-grade dysplasia. Digestion; 2010;82(4):252-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic adenomas found via colonoscopy: yield and risk factors for high-grade dysplasia.
  • BACKGROUND AND AIMS: The adenoma-carcinoma sequence is the model for colorectal carcinoma (CRC) developing through high-grade dysplasia (HGD) to CRC.
  • The aim was to assess prevalence and location of adenomas found during colonoscopy and risk factors for HGD.
  • RESULTS: A total of 3,315 adenomas were removed from 2,385 patients.
  • HGD was found in 135 (4.1%) of the adenomas and tubulovillous/villous histology in 15.0%.
  • The prevalence of adenomas in the 50- to 69-year age group was 15.5%, and 21.5% in the >or=70-year group.
  • Independent risk factors for HGD were in the order of importance: size; multiplicity; tubulovillous/villous histology; location in rectum, and age.
  • The prevalence of HGD in the group with an adenoma size of 0.6-1.0 cm was 4.1% and in the 40- to 69-year age group it was 3.7%.
  • CONCLUSION: The study suggests a potential 15% yield per colonoscopy of adenomas in 50- to 69-year-olds.
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 20588041.001).
  • [ISSN] 1421-9867
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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72. Sasahira T, Akama Y, Fujii K, Kuniyasu H: Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas. Virchows Arch; 2005 Apr;446(4):411-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas.
  • We studied the expression of RAGE in colorectal adenomas to elucidate the role of RAGE in cancer development.
  • Expressions of RAGE and high-mobility group box-1 (HMGB1)/amphoterin RAGE ligand were examined in 96 colorectal adenomas using immunohistochemistry and in situ hybridization, respectively.
  • Of 96 adenomas, 34 (35%) showed RAGE expression.
  • RAGE positivity was significantly higher in adenomas with severe atypia (18/20, P<0.0001) and large-sized adenomas (-15 mm) (18/22, P<0.0001).
  • Membranous pattern was associated with severe atypia, villous histological type, and co-expression with overexpressed HMGB1/amphoterin.
  • These results suggest that RAGE expression, especially with membranous pattern, is associated with malignant potential of colorectal adenomas.
  • [MeSH-major] Adenoma / metabolism. Colorectal Neoplasms / metabolism. HMGB1 Protein / metabolism. Receptors, Immunologic / metabolism

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  • (PMID = 15789216.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / Biomarkers, Tumor; 0 / HMGB1 Protein; 0 / Neoplasm Proteins; 0 / Receptors, Immunologic
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73. Lepur D, Klinar I, Mise B, Himbele J, Vranjican Z, Barsić B: McKittrick-Wheelock syndrome: a rare cause of diarrhoea. Eur J Gastroenterol Hepatol; 2006 May;18(5):557-9
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  • The most frequently reported tumours are villous adenomas.

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  • [CommentIn] Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1047-51 [16957509.001]
  • (PMID = 16607156.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isotonic Solutions
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74. Kim DH, Pickhardt PJ, Taylor AJ: Characteristics of advanced adenomas detected at CT colonographic screening: implications for appropriate polyp size thresholds for polypectomy versus surveillance. AJR Am J Roentgenol; 2007 Apr;188(4):940-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characteristics of advanced adenomas detected at CT colonographic screening: implications for appropriate polyp size thresholds for polypectomy versus surveillance.
  • OBJECTIVE: Advanced adenomas are the primary target in colorectal screening.
  • The purpose of this study was to delineate the prevalence and imaging characteristics of advanced adenomas detected at screening CT colonography (CTC) and the rates of invasive carcinoma and high-grade dysplasia for various polyp size categories.
  • From this group, prevalence, size, histologic features, morphologic features, and location of advanced adenomas were tabulated.
  • Advanced adenomas were defined by size (> or = 10 mm) and/or histologic findings (prominent villous component or high-grade dysplasia).
  • RESULTS: A total of 123 (38.3%) of 321 adenomas measuring 6 mm or more were classified as advanced, the overall prevalence being 3.1% (111 of 3,536 patients).
  • The mean size of advanced adenomas was 16.6 +/- 11.6 mm; most of the lesions (116/123, 94.3%) qualified as advanced on the basis of the size criterion alone.
  • The seven lesions measuring 6-9 mm constituted 3.4% (7/205) of all medium-sized adenomas.
  • The largest percentage (65/123, 52.8%) of the advanced adenomas had tubular histologic features, followed by tubulovillous (50/123, 40.6%), villous (5/123, 4.1%), and serrated (3/123, 2.4%) histologic features.
  • The majority of advanced adenomas were classified as sessile (57/123, 46.3%) or pedunculated (57/123, 46.3%); a small percentage were flat (9/123, 7.3%).
  • Advanced adenomas were located in the proximal colon in 43.9% (54/123) and distal colon in 56.1% (69/123) of the cases.
  • CONCLUSION: Advanced adenomas were generally large (> or = 10 mm in size); only a small percentage were medium sized (6-9 mm).
  • [MeSH-major] Adenoma / radiography. Colonic Neoplasms / radiography. Colonic Polyps / radiography. Colonography, Computed Tomographic
  • [MeSH-minor] Disease Progression. Female. Humans. Male. Middle Aged. Population Surveillance. Retrospective Studies

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  • (PMID = 17377027.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Schiessel R, Novi G, Holzer B, Rosen HR, Renner K, Hölbling N, Feil W, Urban M: Technique and long-term results of intersphincteric resection for low rectal cancer. Dis Colon Rectum; 2005 Oct;48(10):1858-65; discussion 1865-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: One hundred seventeen patients had rectal cancers, two had dysplastic villous adenomas, and two had carcinoid tumors.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Rectal Neoplasms / surgery

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  • (PMID = 16086223.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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76. Beattie GC, Paul I, Calvert CH: Endoscopic transanal resection of rectal tumours using a urological resectoscope--still has a role in selected patients. Colorectal Dis; 2005 Jan;7(1):47-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Transanal resection of rectal villous adenomas or adenocarcinomas can be carried out using various modalities such as operative excision, fulguration, laser coagulation or cryotherapy.
  • The median interval between resections for recurrent disease (excluding planned repeat resections) was 340 days (range 168-2337 days).
  • Histopathology revealed rectal adenoma (with varying degrees of dysplasia) in 11 (55%) patients and adenocarcinoma in 9 (45%).
  • The majority (30; 70%) of resections were carried out in patients with benign disease, with 13 (30%) in patients with rectal adenocarcinoma.
  • No patients with benign disease subsequently developed an invasive carcinoma.
  • CONCLUSIONS: Accepting that this technique provides limited histopathological information regarding extent of resection and tumour clearance, our experience demonstrates that ETAR of rectal tumours using the urological resectoscope can provide a minimally invasive, effective and safe means of treating and palliating patients with benign and malignant rectal disease.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Proctoscopy. Rectal Neoplasms / surgery. Urologic Surgical Procedures / instrumentation

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  • (PMID = 15606584.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Sieg A, Theilmeier A: [Results of coloscopy screening in 2005--an Internet-based documentation]. Dtsch Med Wochenschr; 2006 Feb 24;131(8):379-83
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  • Advanced adenoma was defined as an adenoma >10 mm in diameter, with villous or tubulovillous histology, or presence of high-grade dysplasia.
  • Tubular and villous adenomas were found in 16.2% and 3.8%, respectively, whereas invasive cancers were diagnosed in 0.7%.
  • Advanced adenomas amounted to 6.1%.The majority of carcinomas were detected in early stages (UICC stages I and II in 48 and 22 %, respectively).
  • [MeSH-major] Adenoma / epidemiology. Adenoma, Villous / epidemiology. Carcinoma / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / epidemiology. Internet. Mass Screening. Registries

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  • (PMID = 16479468.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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78. Iordache S, Săftoiu A, Ciurea T, Georgescu CV, Ghiluşi M: Predictive parameters for advanced neoplastic adenomas and colorectal cancer in patients with colonic polyps--a study in a tertiary medical centre in the South-West region of Romania. Rom J Morphol Embryol; 2006;47(3):239-43
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  • [Title] Predictive parameters for advanced neoplastic adenomas and colorectal cancer in patients with colonic polyps--a study in a tertiary medical centre in the South-West region of Romania.
  • Although many papers had described the role of colo-rectal adenomas and the risk for colon cancer, there is a lack of data about epidemiological factors, the histological type, the pit-pattern and type of polyps in Romania.
  • In polypoid adenomas the risk of malignant transformation is well known and is increasing over time, with size and villous architecture.
  • In this paper we evaluate the predictive parameters that allowed us to establish a correlation between the macroscopical aspect and histological architecture of adenomas in our geographical area (South-West region of Romania).
  • The morphology of adenomas and multiplicity of polyps also have a prognostic value.
  • In our study the main localization of polyps was in the left colon, while the main histological type was tubulo-villous adenomas.
  • We consider that the significant parameters for dysplasia and malignant lesions are the size of lesions, multiplicity of polyps and villous architecture.
  • [MeSH-major] Adenoma / diagnosis. Colonic Polyps / diagnosis. Colorectal Neoplasms / diagnosis

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  • (PMID = 17308682.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
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79. Tamiolakis D, Venizelos J, Papadopoulos N, Lambropoulou M, Papadopoulos E, Simopoulos C: Expression of HLA-DR antigen and characterization of the lymphocytic infiltrate in normal mucosa, tubulo-villous adenoma and invasive carcinoma of the colon. Chirurgia (Bucur); 2005 Sep-Oct;100(5):451-6
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  • [Title] Expression of HLA-DR antigen and characterization of the lymphocytic infiltrate in normal mucosa, tubulo-villous adenoma and invasive carcinoma of the colon.
  • The two most important factors having the greatest effect on survival are pathologic stage of disease and histologic grade of the tumor.
  • We studied 31 cases of normal colonic mucosa, 12 cases of tubulo-villous adenoma, and 39 cases of invasive carcinoma for the detection of HLA-DR monoclonal antigen.
  • Yet, we investigated the association of HLA-DR and DQ genes and adenoma and carcinoma by PCR.
  • HLA-DR was expressed in 20 of 31 normal colonic mucosa (64.5%), 4 of 12 adenomas (33.3%), and in 10 of 39 invasive carcinomas (25.6%).
  • No significant correlation between HLA-DR and DQ genes and adenoma or cancer of the colon was found.
  • CD4 was expressed in 9 of 31 normal colonic mucosa (29%), 5 of 12 adenomas (42%), and in 26 of 39 invasive carcinomas (67%).
  • HLA-DR and DQ genes do not contribute to a susceptibility to adenoma or carcinoma.
  • [MeSH-major] Adenoma, Villous / immunology. Antigens, CD4 / analysis. Carcinoma / immunology. Colorectal Neoplasms / immunology. HLA-DR Antigens / analysis. Intestinal Mucosa / immunology

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  • [CommentIn] Ann Saudi Med. 2009 Nov-Dec;29(6):489 [20232495.001]
  • (PMID = 16372671.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Duplicate Publication; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / HLA-DQ Antigens; 0 / HLA-DR Antigens
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80. Zhang X, Leav I, Revelo MP, Deka R, Medvedovic M, Jiang Z, Ho SM: Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon. PLoS Genet; 2009 Jan;5(1):e1000334
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  • By using a panel of immunostained-laser-capture-microdissected clinical samples comprising the entire colon adenoma-carcinoma sequence, we show that deregulation of AMACR during colon carcinogenesis involves two nonrandom events, resulting in the mutually exclusive existence of double-deletion at CG3 and CG10 and deletion of CG12-16 in a newly identified CpG island within the core promoter of AMACR.
  • It existed in histologically normal colonic glands and tubular adenomas with low AMACR expression and was absent in villous adenomas and all CCas expressing variable levels of AMACR.
  • [MeSH-minor] Adenoma, Villous / genetics. Adenoma, Villous / metabolism. Adenoma, Villous / pathology. Base Sequence. Binding Sites. Cell Differentiation. Cell Line, Tumor. Humans. Molecular Sequence Data. Polymorphism, Genetic. Repressor Proteins / metabolism. Sequence Deletion / genetics. Transcription, Genetic

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  • (PMID = 19148275.001).
  • [ISSN] 1553-7404
  • [Journal-full-title] PLoS genetics
  • [ISO-abbreviation] PLoS Genet.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA112532; United States / NCI NIH HHS / CA / R01 CA112532; United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NCI NIH HHS / CA / R01 CA015776; United States / NCI NIH HHS / CA / CA015776; United States / NCI NIH HHS / CA / R01 CA062269; United States / NCI NIH HHS / CA / CA062269
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Repressor Proteins; 0 / ZNF202 protein, human; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
  • [Other-IDs] NLM/ PMC2613032
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81. Lee TS, Kim HK, Ahn HM, Lee UJ, Choi YC, John BM, Park TI, Koo JH: [A case of early bile duct cancer arising from villous adenoma in choledochal cyst]. Korean J Gastroenterol; 2009 Jul;54(1):55-9
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  • [Title] [A case of early bile duct cancer arising from villous adenoma in choledochal cyst].
  • Herein, we report a rare case of bile duct adenoma arising from choledochal cyst with anomalous union of pancreaticobiliary duct (AUPBD).
  • On histological examination, adenoma with focal carcinoma change arising from choledochal cyst was diagnosed.
  • [MeSH-major] Adenoma, Villous / diagnosis. Bile Duct Neoplasms / diagnosis. Choledochal Cyst / diagnostic imaging

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  • (PMID = 19696552.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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82. Rubio CA, Nesi G, Messerini L, Zampi G: Serrated and microtubular colorectal adenomas in Italian patients. A 5-year survey. Anticancer Res; 2005 Mar-Apr;25(2B):1353-9
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  • [Title] Serrated and microtubular colorectal adenomas in Italian patients. A 5-year survey.
  • Colorectal adenomas from 1552 Italian patients were histologically classified into tubular (TAs), tubulo-villous (TVAs), villous (VAs), serrated (SAs) and microtubular (MTAs).
  • The purpose was to compare the results to those in 3135 colorectal adenomas from Swedish patients.
  • Of the 1552 adenomas, 827 (53%) were TAs, 352 (23%) TVAs, 196 (12%) VAs, 102 (7%), SAs and 14 (0.9%) MTAs.
  • The diameter of the largest section was used to define the size of the largest adenoma in individual patients.
  • SAs and MTAs are special adenoma phenotypes with particular morphological and cell proliferative attributes at variance from those of TAs, VAs or TVAs.
  • In the light of the present results, it is proposed that SAs and MTAs are included in future reports of colorectal adenomas in order to compare their frequency worldwide.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 15865091.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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83. Velayos FS, Allen BA, Conrad PG, Gum J Jr, Kakar S, Chung DC, Truta B, Sleisenger MH, Kim YS, Terdiman JP: Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines. Am J Gastroenterol; 2005 May;100(5):1143-9
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  • [Title] Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines.
  • BACKGROUND AND AIM: Screening adenomas for microsatellite instability (MSI) in patients younger than 40 yr of age has been recommended by the Bethesda Guidelines as a means of identifying patients at risk for hereditary nonpolyposis colorectal cancer (HNPCC).
  • We sought to determine the rate of MSI in adenomas removed from individuals under 40 yr of age over a 5-yr period in a university general gastroenterology practice.
  • Patients with polyposis syndromes, inflammatory bowel disease, or colorectal carcinoma were excluded.
  • Adenomas were tested for MSI using the BAT26 and BAT40 microsatellite markers, and expression of the MSH2 and MLH1 proteins was assessed by immunostaining.
  • RESULTS: A total of 34 patients had 46 adenomas removed endoscopically.
  • A total of 28 of 46 adenomas (61%) were distal to the splenic flexure.
  • Five polyps (11%) were tubulovillous adenomas, and the remainder were tubular adenomas.
  • None of the polyps were serrated adenomas and none demonstrated high-grade dysplasia.
  • Among the 40 adenomas available for testing, none demonstrated MSI using either BAT26 (0/40) or BAT40 (0/21), nor did any of the polyps tested demonstrate loss of either MSH2 or MLH1 expression (0/16).
  • CONCLUSION: Screening adenomas from patients younger than 40 yr of age for MSI was ineffective in identifying potentially new cases of HNPCC.
  • [MeSH-major] Adenoma / genetics. Chromosomal Instability / genetics. Colonic Neoplasms / genetics. Microsatellite Repeats / genetics. Rectal Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma, Villous / genetics. Adenoma, Villous / pathology. Adolescent. Adult. Base Pair Mismatch / genetics. Carrier Proteins. Colonic Polyps / genetics. Colonic Polyps / pathology. Colonoscopy. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. DNA-Binding Proteins / genetics. Female. Genetic Predisposition to Disease / genetics. Genetic Testing. Humans. Intestinal Polyps / genetics. Intestinal Polyps / pathology. Male. MutS Homolog 2 Protein. Neoplasm Proteins / genetics. Nuclear Proteins. Proctoscopy. Proto-Oncogene Proteins / genetics. Risk Factors

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  • [CommentIn] Am J Gastroenterol. 2006 Jan;101(1):204 [16405562.001]
  • [CommentIn] Am J Gastroenterol. 2005 May;100(5):1150-3 [15842592.001]
  • (PMID = 15842591.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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84. Kiziltaş S, Sezgin Ramadan S, Topuzoğlu A, Küllü S: Does the severity of tissue eosinophilia of colonic neoplasms reflect their malignancy potential? Turk J Gastroenterol; 2008 Dec;19(4):239-44
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  • This retrospective study aimed to investigate the frequency and intensity of tissue eosinophilia in various colonic neoplasms, including serrated adenomas.
  • METHODS: We evaluated 448 colonic neoplasms to determine eosinophilic infiltration: 96 hyperplastic polyps, 50 serrated adenomas, 19 flat adenomas, 154 tubular adenomas, 71 tubulovillous adenomas, 13 villous adenomas and 45 adenocarcinomas.
  • RESULTS: Moderate (46.7%) and marked (52.9%) intensity were noted in all colonic adenomas.
  • Mostly moderate eosinophilic infiltration was observed in serrated adenomas.
  • CONCLUSIONS: Our findings suggest that the intensity of tissue eosinophilia is most prominent in adenomas including serrated adenomas and is diminished from adenoma to carcinoma.
  • This finding may be used as a diagnostic indicator.

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  • (PMID = 19119482.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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85. Einspahr JG, Martinez ME, Jiang R, Hsu CH, Rashid A, Bhattacharrya AK, Ahnen DJ, Jacobs ET, Houlihan PS, Webb CR, Alberts DS, Hamilton SR: Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics. Cancer Epidemiol Biomarkers Prev; 2006 Aug;15(8):1443-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics.
  • In colorectal tumorigenesis, Ki-ras proto-oncogene mutation often occurs early in the adenoma-adenocarcinoma sequence, whereas mutation of the p53 gene is associated with late progression to carcinoma.
  • We evaluated the relationship of demographic and clinicopathologic characteristics to Ki-ras mutation and p53 gene product overexpression in 1,093 baseline sporadic colorectal adenomas from 926 individuals enrolled in a phase III recurrence prevention trial.
  • Multivariate analysis found older age, rectal location, and villous histology to be independently associated with Ki-ras mutation.
  • Individuals with an advanced adenoma (>or=1 cm or high-grade dysplasia or villous histology) had a 4-fold higher likelihood of Ki-ras mutation [odds ratios (OR), 3.96; 95% confidence intervals (CI), 2.54-6.18].
  • Ki-ras mutations in codon 12 and of the G-to-A transition type were more frequent in older individuals, whereas G-to-T transversion was more frequent in rectal adenomas than in the colon.
  • Large adenoma size (>or=1 cm), high-grade dysplasia, and villous histology were independently associated with p53 overexpression, with the strongest association for advanced adenomas (OR, 7.20; 95% CI, 3.01-17.22).
  • Individuals with a Ki-ras mutated adenoma were more likely to overexpress p53 (OR, 2.46; 95% CI, 1.36-4.46), and 94.8% of adenomas with both alterations were classified as advanced (P <or= 0.0001).
  • Our large cross-sectional study supports the role of both Ki-ras and p53 in the progression of adenomas and shows that their molecular pathogenesis differs by anatomic location, age, and mucosal predisposition as evidenced by previous history of a polyp.

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  • (PMID = 16896030.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA023074; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / CA16672; United States / NCI NIH HHS / CA / P01 CA041108; United States / NCI NIH HHS / CA / CA23074; United States / NCI NIH HHS / CA / CA41108
  • [Publication-type] Clinical Trial, Phase III; Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS430412; NLM/ PMC3547362
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86. Jin Z, Yin L, Xue L, Lin M, Zheng Q: Anorectal functional results after transanal endoscopic microsurgery in benign and early malignant tumors. World J Surg; 2010 May;34(5):1128-32
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  • BACKGROUND: Transanal endoscopic microsurgery (TEM) has been suggested as a minimally invasive procedure of low morbidity for rectal villous adenomas and early anorectal adenocarcinomas.
  • RESULTS: Of the 37 patients, 24 had villous adenomas and 13 had adenocarcinomas (11 uT1 and 2 uT2).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / physiopathology. Anus Neoplasms / surgery. Rectal Neoplasms / surgery. Rectum / physiopathology

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  • (PMID = 20225126.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Schneider AR, Seifert H, Trojan J, Stein J, Hoepffner NM: Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study. Z Gastroenterol; 2005 Oct;43(10):1123-7

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  • [Title] Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study.
  • METHODS: 26 consecutive patients (16 women, 10 men; median age 59 years) with sporadic adenomas (n = 19) or adenocarcinomas (n = 7) of the ampulla of Vater were retrospectively evaluated.
  • However, the finding of 2 rectal carcinomas among patients with ampullary neoplasms supports the place of screening colonoscopy for the diagnostic work-up of ampullary tumors.
  • [MeSH-major] Adenocarcinoma / complications. Adenoma / complications. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Intestinal Polyps / epidemiology
  • [MeSH-minor] Adenoma, Villous / complications. Adenoma, Villous / surgery. Adenomatous Polyposis Coli / epidemiology. Adult. Aged. Aged, 80 and over. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 16220451.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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88. Bansal A, Liu X, McGregor DH, Singh V, Hall S: Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series. Am J Med Sci; 2010 Oct;340(4):296-300
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  • [Title] Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series.
  • Although EGFR is described to be overexpressed in adenomas, to the authors' knowledge, its relationship with advanced features in adenomas and as a marker for adenoma progression has not been studied.
  • Subsequently, a validation group of 95 adenomas from 16 patients were graded semiquantitatively for EGFR staining.
  • Size and villous features of the adenomas were evaluated by 2 independent pathologists and compared with EGFR expression.
  • To be classified as advanced, adenomas needed to be greater than 1 cm and fulfill 1 of the 2 criteria-villous component >20% to 25% or presence of high-grade dysplasia.
  • RESULTS: In the index case, the large 5.5 cm tubulovillous adenoma had EGFR positivity in all of its neoplastic cells, whereas another 2 cm tubular adenoma with focal villous features had 30% EGFR positivity.
  • In 95 adenomas from 16 additional patients, there was a significant correlation of EGFR positivity with adenoma size ≥1 cm and villous features (all P < 0.001).
  • The odds of EGFR expression in advanced adenomas were 17.3 times higher than nonadvanced adenomas (P < 0.001).
  • CONCLUSIONS: These findings suggest that EGFR overexpression is associated with advanced colorectal adenomas.
  • Further larger studies are needed to explore EGFR expression as a biomarker for adenoma progression.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Receptor, Epidermal Growth Factor / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Cohort Studies. Colon / metabolism. Colonic Polyps / metabolism. Colonic Polyps / pathology. Disease Progression. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Male. Middle Aged. Pilot Projects

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  • (PMID = 20622650.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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89. Jones M, Helliwell P, Pritchard C, Tharakan J, Mathew J: Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship? World J Surg Oncol; 2007;5:51
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  • METHODS: Paraffin processed colonic tissue blocks of normal colonic mucosa (n = 60), and patients diagnosed as adenoma (n = 60), and adenocarcinoma (n = 60) were retrieved from our archive; the adenoma group included tubular (n = 20), tubulovillous (n = 20) and villous adenomas (n = 20).
  • RESULTS: Significant numbers of Helicobacter pylori were identified in tubular adenomas (OR = 11.13; 95%CI = 1.62-76.70), tubulovillous adenomas (OR = 10.45; 95%CI = 1.52-71.52) and adenocarcinomas (OR = 8.13; 95%CI = 1.40-46.99) compared to controls: there was no association in numbers of Helicobacter pylori and villous adenomas (OR = 2.95; 95%CI = 0.29-9.96).
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / microbiology. Adenoma / epidemiology. Adenoma / microbiology. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Female. Humans. Incidence. Intestinal Mucosa / microbiology. Intestinal Mucosa / pathology. Male. Middle Aged. Odds Ratio. Pilot Projects. Reference Values. Risk Assessment. Sampling Studies. Sensitivity and Specificity

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  • (PMID = 17498313.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Bacterial
  • [Other-IDs] NLM/ PMC1885433
  • [General-notes] NLM/ Original DateCompleted: 20070807
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90. Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, Saibil F, Ueland PM, Greenberg ER, Polyp Prevention Study Group: Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA; 2007 Jun 6;297(21):2351-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.
  • OBJECTIVE: To assess the safety and efficacy of folic acid supplementation for preventing colorectal adenomas.
  • Participants included 1021 men and women with a recent history of colorectal adenomas and no previous invasive large intestine carcinoma.
  • MAIN OUTCOME MEASURES: The primary outcome measure was occurrence of at least 1 colorectal adenoma.
  • Secondary outcomes were the occurrence of advanced lesions (> or =25% villous features, high-grade dysplasia, size > or =1 cm, or invasive cancer) and adenoma multiplicity (0, 1-2, or > or =3 adenomas).
  • RESULTS: During the first 3 years, 987 participants (96.7%) underwent colonoscopic follow-up, and the incidence of at least 1 colorectal adenoma was 44.1% for folic acid (n = 221) and 42.4% for placebo (n = 206) (unadjusted risk ratio [RR], 1.04; 95% confidence interval [CI], 0.90-1.20; P = .58).
  • A total of 607 participants (59.5%) underwent a second follow-up, and the incidence of at least 1 colorectal adenoma was 41.9% for folic acid (n = 127) and 37.2% for placebo (n = 113) (unadjusted RR, 1.13; 95% CI, 0.93-1.37; P = .23); and incidence of at least 1 advanced lesion was 11.6% for folic acid (n = 35) and 6.9% for placebo (n = 21) (unadjusted RR, 1.67; 95% CI, 1.00-2.80; P = .05).
  • Folic acid was associated with higher risks of having 3 or more adenomas and of noncolorectal cancers.
  • CONCLUSIONS: Folic acid at 1 mg/d does not reduce colorectal adenoma risk.


91. Yantiss RK, Oh KY, Chen YT, Redston M, Odze RD: Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases. Am J Surg Pathol; 2007 Aug;31(8):1238-45
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  • [Title] Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases.
  • In this study, we describe a previously uncharacterized type of adenomatous polyp of the colorectum that shows prominent, thin, elongated projections of neoplastic epithelium with a serrated contour, which we have termed "filiform serrated adenoma" (SA).
  • Four (22%) filiform SAs also contained nonserrated adenomatous elements with a villous (3 cases) or tubular (1 case) growth pattern.

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  • (PMID = 17667549.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Genetic Markers; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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92. Platell C, Salama P, Barwood N, Makin G: Performing a colonoscopy 12 months after surgery for colorectal neoplasia. ANZ J Surg; 2005 May;75(5):282-5
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  • On histology, 42% were tubular adenomas, 6% tubulo-villous adenomas, 7% were villous adenomas, and 37% were hyperplastic.
  • Advanced adenomas were identified in 7.9% of patients (95% CI 4.8-12.1%).
  • CONCLUSION: We have observed a high prevalence of advanced adenomas in patients undergoing a 12-month, follow-up colonoscopy after curative surgery for colorectal neoplasia.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Second Primary / diagnosis

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  • [CommentIn] ANZ J Surg. 2005 May;75(5):257-8 [15932431.001]
  • (PMID = 15932437.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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93. Rennert G, Almog R, Tomsho LP, Low M, Pinchev M, Chaiter Y, Bonner JD, Rennert HS, Greenson JK, Gruber SB: Colorectal polyps in carriers of the APC I1307K polymorphism. Dis Colon Rectum; 2005 Dec;48(12):2317-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared.
  • Adenomas with a tubular component (either tubular adenomas or tubulovillous adenomas), but not villous adenomas, were significantly more frequent among carriers (37.2 percent vs. 23.6 percent, P = 0.005).
  • CONCLUSION: Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
  • [MeSH-major] Adenoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. Genes, APC. Polymorphism, Genetic

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  • (PMID = 16228836.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Lin GL, Meng WC, Lau PY, Qiu HZ, Yip AW: Local resection for early rectal tumours: Comparative study of transanal endoscopic microsurgery (TEM) versus posterior trans-sphincteric approach (Mason's operation). Asian J Surg; 2006 Oct;29(4):227-32
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  • METHODS: The study group comprised 31 consecutive patients with early rectal tumours (18 villous adenomas, 13 adenocarcinomas) who underwent TEM in Kwong Wah Hospital, Hong Kong.
  • The control group consisted of 51 patients with early rectal tumours (27 villous adenomas, 24 adenocarcinomas) who underwent Mason's operation in Peking Union Medical College Hospital, Beijing.

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  • (PMID = 17098653.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
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95. Rubio CA, Stemme S, Jaramillo E, Lindblom A: Hyperplastic polyposis coli syndrome and colorectal carcinoma. Endoscopy; 2006 Mar;38(3):266-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Other colorectal lesions were found as follows: two patients each had one mixed polyp; there were 15 serrated adenomas in eight patients; and there were 30 tubular, tubulovillous, or villous adenomas in eight patients.
  • Of the four villous adenomas, three were associated with a CRC, but only one of the 15 serrated adenomas was associated with a CRC.
  • [MeSH-minor] Adenoma / pathology. Aged. Colonic Neoplasms / pathology. Female. Humans. Hyperplasia. Male. Middle Aged

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  • (PMID = 16528654.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 35
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96. Targarona EM, Hernandez PM, Balague C, Martinez C, Hernández J, Pulido D, Berindoague R, Trias M: McKittrick-Wheelock syndrome treated by laparoscopy: report of 3 cases. Surg Laparosc Endosc Percutan Tech; 2008 Oct;18(5):536-8
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  • AIM: To present 3 cases of secreting villous adenoma (McKittrick-Wheelock syndrome) successfully treated with laparoscopic surgery.
  • Owing to the extension and location of the adenomas, laparoscopic surgery (low anterior resection or procto-sigmoidectomy resection) was performed after medical treatment and endoscopic diagnosis.
  • CONCLUSIONS: When colonoscopic resection is not feasible in cases of secreting villous adenomas owing to their size or location, laparoscopic surgery in expert hands is a safe, effective, and complete option, further enhanced by the benefits of minimally invasion surgery.
  • [MeSH-major] Adenoma, Villous / surgery. Colorectal Neoplasms / surgery. Laparoscopy. Rectum / surgery. Water-Electrolyte Imbalance / etiology

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  • (PMID = 18936686.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Rubio CA: Neoplasias of the colorectal crypts. Anticancer Res; 2005 Nov-Dec;25(6C):4551-8
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  • Colorectal cancers are often preceded by noninvasive neoplasias arising in the surface epithelium, namely tubular, tubulovillous and villous adenomas.
  • The material included 502 adenomas, 865 invasive tumours and 221 cases of ulcerative colitis (UC).
  • Over the 5-year period, the most frequent phenotype encountered was single crypt dysplasia (in all 5 colectomies from familial adenomatous polyposis patients), followed by serrated adenomas (11.2%), hyperplastic polyps (8.4%), dysplasia in UC (6.3%), pure carcinoid tumours (1.7%), signet ring cell carcinoma (1.1%), adenocarcinoid tumours (0.2%) and de novo carcinomas (0.1%).
  • In this survey, no case of Paneth cell adenoma or of cryptal neoplasia in lymphoid-associated mucosa (also known to originate from the crypts) was found.
  • [MeSH-minor] Adenoma / pathology. Adenomatous Polyposis Coli / pathology. Female. Goblet Cells / pathology. Humans. Intestinal Mucosa / pathology. Male. Paneth Cells / pathology

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  • (PMID = 16334140.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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98. Galamb O, Sipos F, Spisák S, Galamb B, Krenács T, Valcz G, Tulassay Z, Molnár B: Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genes. Cell Oncol; 2009;31(1):19-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genes.
  • BACKGROUND: As most colorectal cancers (CRC) develop from villous adenomas, studying alterations in gene expression profiles across the colorectal adenoma-dysplasia-carcinoma sequence may yield potential biomarkers of disease progression.
  • METHODS: Total RNA was extracted, amplified, and biotinylated from colonic biopsies of 15 patients with CRC, 15 with villous adenoma and 8 normal controls.
  • Gene expression profiles were evaluated using HGU133Plus2.0 microarrays and disease progression associated data were validated with RT-PCR.
  • RESULTS: 17 genes were validated to show sequentially altered expression at mRNA level through the normal-adenoma-dysplasia-carcinoma progression.
  • CONCLUSIONS: Downregulated AMN and PTGDR and upregulated osteopontin and osteonectin were found as potential biomarkers of colorectal carcinogenesis and disease progression to be utilized for prospective biopsy screening both at mRNA and protein levels.
  • [MeSH-major] Adenoma / genetics. Biomarkers, Tumor / genetics. Colorectal Neoplasms / genetics. Disease Progression. Gene Expression Profiling. Gene Expression Regulation

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  • (PMID = 19096147.001).
  • [ISSN] 1875-8606
  • [Journal-full-title] Cellular oncology : the official journal of the International Society for Cellular Oncology
  • [ISO-abbreviation] Cell. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC4618585
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99. Lin OS, Schembre DB, McCormick SE, Gluck M, Patterson DJ, Jiranek GC, Soon MS, Kozarek RA: Risk of proximal colorectal neoplasia among asymptomatic patients with distal hyperplastic polyps. Am J Med; 2005 Oct;118(10):1113-9
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Our goal is to assess the risk of proximal neoplasia in asymptomatic patients with distal hyperplastic polyps, compared to those with distal tubular adenomas or no distal polyps.
  • METHODS: We assessed proximal (cecum, ascending, transverse colon and splenic flexure) and distal polyps in patients undergoing screening colonoscopy, classifying them into 3 groups: distal hyperplastic polyps only; distal adenomas with or without hyperplastic polyps; no distal polyps.
  • The prevalence of proximal neoplasia and advanced neoplasia (polyps > or =1 cm, villous adenomas, or cancer) was compared among these groups.
  • Proximal neoplasia occurred in 175 (9%) of 1896 patients with no distal polyps, compared with 28 (12%) of 237 with distal hyperplastic polyps (P = 0.20) and 64 (29%) of 224 with distal adenomas (P <0.0001).
  • Proximal advanced neoplasia occurred in 39 (2%) patients with no distal polyps, compared with 4 (2%) with distal hyperplastic polyps (P = 0.70) and 9 (4%) with distal adenomas (P = 0.13).
  • CONCLUSIONS: Patients with distal hyperplastic polyps, unlike those with distal adenomas, do not exhibit an increased risk for proximal neoplasia or proximal advanced neoplasia compared to those with no distal polyps.
  • [MeSH-major] Adenoma / epidemiology. Colon / pathology. Colorectal Neoplasms / epidemiology. Intestinal Polyps / epidemiology. Precancerous Conditions / epidemiology. Rectum / pathology

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  • (PMID = 16194642.001).
  • [ISSN] 0002-9343
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Artifon EL, Sakai P, Baracat R, Moura EG: Endoscopic ampullectomy in a patient with a duodenal diverticulum. A challenging procedure. Rev Gastroenterol Mex; 2010;75(2):199-202

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Biopsy of the ampulla was positive for villous adenoma.
  • [MeSH-major] Adenoma, Villous / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Digestive System

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  • (PMID = 20615792.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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