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6. Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP: [Human kallikrein 13 expression in salivary gland tumors]. Int J Biol Markers; 2006 Apr-Jun;21(2):106-110

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Human kallikrein 13 expression in salivary gland tumors].
  • Petraki et al have previously described presence of hK13 in salivary gland tissue, localized to duct epithelia and some acinar cells.
  • The aim of this study was to determine whether hK13 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid carcinomas (MEC) and adenocarcinomas not otherwise specified (ANOS) of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of hK13.
  • Overall, staining in PA was significantly less than that seen in normal salivary gland tissue.
  • PLGA, ACC and ANOS each stained significantly more than normal salivary gland tissue while MEC and ACI did not.
  • Ductal cells and cells lining duct-like structures showed a higher intensity of staining than non-ductal cells in most tumors.
  • Tumors which exhibited only non-ductal cells also exhibited cytoplasmic staining.
  • In conclusion, we demonstrate the high expression of hK13 in several common salivary gland tumors.

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  • (PMID = 28207129.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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7. Smiri KH, Fenniche S, Marrak H, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I: [Chondroid syringoma]. Tunis Med; 2005 Jun;83(6):372-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Chondroid syringoma].
  • [Transliterated title] Le syringome chondroïde.
  • Chondroid syringoma is a benign sweat gland tumor.
  • This lesion is electively located in the craniofacial area, made of a subcutaneous painless tumor measuring from 0.5 to 3 cm.
  • Diagnosis can always be confirmed by histology which shows tubuloalveolar and gland like structures with two or more cuboidal cell lines in a fibroadipoid or chondroid stroma that is positively stained for Alcian blue.
  • Mixed tumors have a slow course; their progress to malignancy is rare but possible.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Disease Progression. Humans. Male. Middle Aged. Patient Satisfaction. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 16156416.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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8. Varsori M, Dettwiler S, Chaloupka K: [Eyelid chondroid syringoma: a case report]. J Fr Ophtalmol; 2007 Jan;30(1):e3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Eyelid chondroid syringoma: a case report].
  • [Transliterated title] Syringome chondroïde de la paupière: à propos d'un cas.
  • Chondroid syringoma is a rare benign skin tumor of the head and neck.
  • The lesion was surgically removed, and the histopathological examination showed a chondroid syringoma.
  • Knowledge of this disease is important because malignant transformations do occur.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eyelid Neoplasms / diagnosis

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  • (PMID = 17287665.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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9. Sato K, Ueda Y, Shimasaki M, Ozaki M, Nitta N, Chada K, Ishikawa Y, Katsuda S: Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. Pathol Res Pract; 2005;201(4):333-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature.
  • We report a case of pleomorphic adenoma (benign mixed tumor) of the breast, which is an extremely rare location for this tumor.
  • Examination of a 55-year-old woman unexpectedly revealed a mass measuring 0.8 cm in diameter in the subareolar region of the right breast.
  • Excisional biopsy was performed, and the tumor histologically showed pleomorphic adenoma composed of duct epithelial cells, myoepithelial cells, and a myxochondroid matrix.
  • The nuclei of the spindle and myoepithelial cells were immunoreactive for HMGI-C and HMGI(Y) proteins, indicating a histogenesis similar to pleomorphic adenoma of the salivary glands.
  • Sixty-nine cases of this type of tumor arising in the breast have been described previously.
  • Using imaging procedures, the tumor has occasionally been misdiagnosed as malignant clinically and even pathologically in frozen section diagnosis.
  • Careful diagnosis based on paraffin sections is required to avoid unnecessary aggressive surgery, and pathologists should include pleomorphic adenoma in the differential diagnosis of a demarcated, juxtaareolar, small hard mass.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. HMGA1a Protein / analysis. HMGA2 Protein / analysis. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Middle Aged. Receptors, Estrogen / analysis

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  • (PMID = 15991841.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; 0 / Receptors, Estrogen; 124544-67-8 / HMGA1a Protein
  • [Number-of-references] 32
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10. Chimona TS, Koutsopoulos AV, Malliotakis P, Nikolidakis A, Skoulakis C, Bizakis JG: Malignant mixed tumor of the nasal cavity. Auris Nasus Larynx; 2006 Mar;33(1):63-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant mixed tumor of the nasal cavity.
  • Parotid gland is the most common location of malignant mixed tumors.
  • Three different subtypes of these tumors exist: carcinoma ex pleomorphic adenoma, carcinosarcoma, and metastasizing mixed tumor.
  • Carcinoma ex-pleomorphic adenoma is by far the most common subtype.
  • Although unusual sites of these tumors have been published, we report an extremely rare case of a malignant mixed tumor located in the nasal cavity.
  • [MeSH-major] Mixed Tumor, Malignant / pathology. Nasal Cavity / pathology. Nose Neoplasms / pathology

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  • (PMID = 16188415.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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11. Sivamani R, Wadhera A, Craig E: Chondroid syringoma: case report and review of the literature. Dermatol Online J; 2006;12(5):8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma: case report and review of the literature.
  • The lesion had been excised 4 years prior and was diagnosed as chondroid syringoma, but had gradually regrown.
  • Histopathological examination was again consistent with chondroid syringoma, and showed the following:.
  • 1) a chondroid matrix, 2) tubuloalveolar structures lined by a double epithelium, 3) ductal structures lined by a single epithelium, 4) nests of polygonal cells, and 5) the presence of keratinous cysts.
  • Chondroid syringoma is a rare mixed tumor of the skin that was first described by Hirsch and Helwig.
  • Characteristically, it is composed of a proliferation of epithelial cells set in a myxoid and chondroid matrix.
  • Although chondroid syringomas are predominantly benign, malignant forms have been reported.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Facial Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16962023.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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12. Kerimoglu U, Aydingoz U, Ozkaya O, Aksu AE, Ergen FB: MRI of a benign chondroid syringoma. Br J Radiol; 2006 Aug;79(944):e59-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of a benign chondroid syringoma.
  • Chondroid syringoma, also known as mixed tumour of the skin, is a relatively rare, usually benign tumour.
  • A few malignant cases, especially in the lower extremities, have been published, but most of them behave in a benign fashion.
  • A case of a middle-aged woman with surgically proved chondroid syringoma in the pretibial region is presented in this report with MRI and histological findings.
  • Despite rapid growth over a short period of time and a location reportedly associated with malignancy, the histological features were benign.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16861320.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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13. Davidson JA, Wong V, Fraser R, Hirsh V: Comparison of primary tumor maximal standardized uptake value (SUV<sub>max</sub>) on preoperative [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and histological subtype in patients with non-small cell lung cancer (NSCLC). J Clin Oncol; 2009 May 20;27(15_suppl):7571

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of primary tumor maximal standardized uptake value (SUV<sub>max</sub>) on preoperative [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and histological subtype in patients with non-small cell lung cancer (NSCLC).
  • The SUV<sub>max</sub> is a semiquantitative measure of metabolic activity that can distinguish benign from malignant tissue but published data are conflicting regarding its ability to discriminate between major histological subtypes.
  • The SUV<sub>max</sub> values for each histological subtype, along with primary tumor sizes, were compared using F test and t-test analyses.
  • RESULTS: The 15 patients with SC and 5 with LC histology were found to have significantly greater preoperative SUV<sub>max</sub> values than the 19 patients with AC (mean 12.7 and 17.2 vs. 9.4, respectively, P < 0.05), despite the fact that no significant differences in tumor size were observed between histological subtypes.
  • CONCLUSIONS: These data suggest that SC pulmonary tumors have significantly greater uptake on PET/CT than AC tumors.
  • This finding may be helpful in the future when sufficient tissue cannot be obtained for pathological diagnosis or to identify the predominant pathology of mixed tumors.

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  • (PMID = 27963356.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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1
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4. Piulats JM Sr, Nadal M, Martinez-Iniesta M, Puertas S, Gonzalez S, Vidal A, Condom E, Germa-Lluch J, Garcia Del Muro X, Villanueva A: Nude mice model of primary human nonseminoma germ cell tumors to study biology and resistance to cisplatin treatment. J Clin Oncol; 2009 May 20;27(15_suppl):e16143

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nude mice model of primary human nonseminoma germ cell tumors to study biology and resistance to cisplatin treatment.
  • : e16143 Testicular germ cell tumors (TGCTs) are the most common malignancy in young men.
  • Recently, our group has reported the development of a model of human nonseminoma (NSE) after orthotopic nude mice implantation (Piulats et al, Amer Assoc Cancer Res. 2006).
  • Pure and mix NSE anatomies were represented and they reproduce the main histological, genetic and epigenetic characteristics of paired primary tumors.
  • Xenografts mimic distal dissemination patterns and cisplatin (CDDP) tumor behavior responses.
  • We have generated in vivo five tumors showing increased resistance to CDDP by exposition to repetitive cycles and increasing the dose applied through different passages (1 yolk-sac; 1 choriocarcinoma; 2 embrional carcinoma; 1 mix tumor).
  • A shortness time elipse between pasajes was observed for each tumor through CDDP treatments.
  • To confirm increasin resistance, a parallel assay of chemotherapy response was performed between nontreated and CDDP resistant tumors.
  • Whole genome analysis of tour xenografted tumors and their paired CDDP resistant tumor (#3 and #5 passage) were analyzed by CGH NimbeGen arrays using 60 Kb average windows.
  • Few differential genomic changes were identified some of them were consistent across resistant tumors including gain of 9q21.11-9q33.3, 15q23-15q24.1, and 15q26.3 regions and loss of Xp22.33.
  • In one tumour showing strong CDDP resistance compared with its sensitive counterpart it occur in absence of new genomic changes.
  • No changes in the MSI or mutational TP53 status were observed in resisant tumors.
  • Our data suggest that acquisition of tumor resistance to CDDP in TGCTs may proably depend of a combination of different mechanisms, including cromosomal imbalances.

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  • (PMID = 27963427.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Price PM, Asselin M, Koetz B, Dickinson C, Charnley N, Lorigan P, Valle J, Stratford M, Rustin G, Saleem A: A PET imaging study of the vascular disruptive agent OXi4503 to confirm in vivo mechanism of action in a phase I trial. J Clin Oncol; 2009 May 20;27(15_suppl):e14510

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2 pts with MM (3.8 & 6.5 mg/m<sup>2</sup>) achieved stable disease.
  • Sustained tumour blood perfusion reduction (50% at 90min & 24hr) was seen in all metastases in the CRC pt treated at 15.4 mg/m<sup>2</sup> after just one dose & resulted in FDG reduction (23% in all 5 mets) & tumor marker response.
  • Doses between 1.9 & 11.0 mg/m<sup>2</sup> produced dose independent reductions in tumour perfusion which were more variable & less marked with 3/8 pts showing a reduction in tumour FDG uptake.
  • The 1pt studied at 28 days (8.5 g/m<sup>2</sup>) showed further sustained reduction in tumour blood flow (40%).
  • Characterisation of the mixed tumour perfusion response at lower doses will aid planning & assessing combination studies.

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  • (PMID = 27963518.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Schmidt LA, Olsen SH, McHugh JB: Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy. Am J Surg Pathol; 2010 Aug;34(8):1205-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy.
  • Cutaneous adnexal differentiation is well-recognized in benign mixed tumors occurring in cutaneous sites.
  • The incidence of this histologic finding in salivary gland sites is not known.
  • We sought to describe the incidence of cutaneous adnexal differentiation in benign mixed tumors of the palate, lip, and parotid gland.
  • Benign mixed tumors of the palate (n=30), lip (n=13), and parotid gland (n=37) resected between 1980 and 2009 at a single academic medical institution were reviewed.
  • After confirming the diagnosis of benign mixed tumor, we evaluated for morphologic evidence of cutaneous adnexal differentiation and metaplastic epithelial and stromal changes.
  • Cutaneous adnexal differentiation was seen in 20% of palate and 39% of lip benign mixed tumors but in no parotid tumors.
  • The most frequent features of cutaneous adnexal differentiation were tricholemmal differentiation (20% of palate and 39% of lip tumors), infundibulocystic structures (17% and 31%), and trichohyalin granules (13% and 31%).
  • Sebaceous differentiation was seen in only one palate tumor.
  • Varying amounts of stromal adipose were seen in 62, 37, and 22% of lip, palate, and parotid tumors.
  • Osseous metaplasia was seen in one tumor from each site.
  • When cutaneous adnexal differentiation occurs in salivary gland pleomorphic adenomas, it can present a diagnostic pitfall that must not be misinterpreted as carcinoma at biopsy, fine needle aspiration, or frozen section.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Cell Differentiation. Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Mouth Neoplasms / pathology. Stromal Cells / pathology

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  • (PMID = 20661019.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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17. Rauso R, Santagata M, Tartaro G, Filipi M, Colella G: Chondroid syringoma: a rare tumor of orofacial region. Minerva Stomatol; 2009 Jul-Aug;58(7-8):383-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma: a rare tumor of orofacial region.
  • Chondroid syringoma is a rare tumor arising from the major and minor salivary glands.
  • The incidence of chondroid syringoma is reported to be <0.01% among the primary skin tumors.
  • Eighty percent of the chondroid syringomas are seen in older patients , commonly on head and neck region and mostly on the cheek and nose.
  • The authors report a case discussing the surgical management of a chondroid syringoma and pointing out the importance of including this tumor in the differential diagnosis of small subcutaneous nodules in the head and neck region, in middle-age male patients.
  • [MeSH-major] Adenoma, Pleomorphic. Facial Neoplasms. Mouth Neoplasms

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  • (PMID = 19633639.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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18. Constantinescu MB, Chan JB, Cassarino DS: Chondroid syringoma with tyrosine crystals: case report and review of the literature. Am J Dermatopathol; 2010 Apr;32(2):171-4
Hazardous Substances Data Bank. L-TYROSINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma with tyrosine crystals: case report and review of the literature.
  • Chondroid syringoma (CS) is a relatively rare cutaneous mixed tumor arising from sweat glands.
  • CSs share morphologic similarities with their salivary gland counterparts, pleomorphic adenomas (benign mixed tumors).
  • Although the presence of tyrosine-rich crystalloids in mixed tumors of the salivary gland is well recognized, to our knowledge, this finding has not been previously described in mixed tumors of the skin.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / metabolism. Syringoma / diagnosis. Syringoma / metabolism. Tyrosine / metabolism

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  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for syringoma .
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  • (PMID = 19851085.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 42HK56048U / Tyrosine
  • [Number-of-references] 29
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19. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Chondroid syringoma: a clinical and histological review of eight cases].
  • [Transliterated title] Siringoma condroide: revisión clínica e histológica de ocho casos.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • MATERIAL AND METHODS: Eight cases diagnosed of chondroid syringoma in our Department in the last eight years were reevaluated clinically and histologically and the epiluminiscence microscopy was used in one of them.
  • All the cases had a myxoid matrix and most also had a chondroid one.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • The microscopic examination of these lesions reveals tubuloalveolar and glandular type structures positioned as islets within a fibroadipose, chondroid, myxoid or hyaline stroma.
  • The final treatment of these tumors is surgical.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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20. Karnwal A, Pakalapati S, Tzifa K, Raut V: Chondroid syringoma of the external ear canal presenting as a cyst. Kulak Burun Bogaz Ihtis Derg; 2006;16(2):80-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma of the external ear canal presenting as a cyst.
  • Chondroid syringoma of the external ear canal is a rare, usually firm or polypoid tumor, representing the cutaneous counterpart of pleomorphic adenoma of salivary glands.
  • We report a very rare case of chondroid syringoma in a 40-year-old man who presented with a fluid-containing cyst in the external ear canal.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ear Neoplasms / diagnosis. Ear, External / pathology

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  • (PMID = 16763421.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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21. Steele NP, Wenig BM, Sessions RB: A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node. Am J Otolaryngol; 2007 Mar-Apr;28(2):130-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.
  • OBJECTIVE: Pleomorphic adenomas are the most common salivary gland tumors and are typically cured with complete surgical excision.
  • There are rare reports, however, in which these histologically benign tumors have inexplicably metastasized to distant sites.
  • We present a case of a patient who presented, 27 years after excision of a parotid pleomorphic adenoma, with a recurrence in the parotid bed and a mediastinal metastasis.
  • METHODS: A 43-year-old woman presented with a mass in the right parotid bed 27 years after excision of a pleomorphic adenoma of the parotid.
  • The patient's presentation, workup, and final diagnosis of benign metastasizing pleomorphic adenoma will be discussed, along with a pertinent review of the literature.
  • RESULTS: A diagnosis of recurrent pleomorphic adenoma was made from a fine needle aspiration biopsy of the right parotid mass.
  • On subsequent computed tomographic scan, chest images revealed an incidental left mediastinal mass, which also proved to be a pleomorphic adenoma on computed tomography-guided fine needle aspiration biopsy.
  • Examination of the pathology specimens confirmed a diagnosis of pleomorphic adenoma in both the parotid bed and the mediastinum.
  • No histologic characteristics of malignancy were seen in either specimen; therefore, a diagnosis of benign metastasizing mixed tumor was rendered.
  • CONCLUSION: Benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity.
  • Although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasize to distant sites.
  • It remains to be determined whether these benign metastasizing pleomorphic adenomas are really low-grade salivary malignancies.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17362821.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. López Campos D, Campos Bañales ME, López Aguado D: [Primary pleomorphic adenoma (chondroid syringoma) of the external auditory canal. Case report and literature review]. Acta Otorrinolaringol Esp; 2008 May;59(5):252-3
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  • [Title] [Primary pleomorphic adenoma (chondroid syringoma) of the external auditory canal. Case report and literature review].
  • [Transliterated title] Adenoma pleomórfico primario (siringoma condroide) del conducto auditivo externo. A propósito de un caso y revisión de la literatura.
  • Chondroid syringoma of the external auditory canal is an extremely rare neoplasm, representing the cutaneous counterpart of pleomorphic adenoma of salivary glands.
  • This tumour is thought to derive from the apocrine duct of the folliculo-sebaceous-apocrine unit.
  • We report the case of a 68-year-old male in whom the clinical and radiological examinations showed a well-circumscribed tumour limited to the external auditory canal.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear Neoplasms / pathology. Ear, External / pathology

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  • (PMID = 18501163.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 12
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23. Hafezi-Bakhtiari S, Al-Habeeb A, Ghazarian D: Benign mixed tumor of the skin, hypercellular variant: a case report. J Cutan Pathol; 2010 Sep;37(9):e46-9
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  • [Title] Benign mixed tumor of the skin, hypercellular variant: a case report.
  • Microscopic examination showed a well-circumscribed dermally located tumor composed of ductal elements lined by double to multiple cell layers of bland cuboidal inner cells and elongated spindled outer cells with areas showing cribriform and solid growth patterns.
  • The overall morphology and immunohistochemical profile are that of a benign cutanoues mixed tumor (chondroid syringoma).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Epidermal Cyst / diagnosis. Humans. Immunohistochemistry. Male. Scalp

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  • (PMID = 19614993.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Magro G, Floridia F, Geraci G, Marino B: Lipomatous apocrine mixed tumor of the skin: an unusual giant lesion occurring in the breast. J Cutan Pathol; 2009 Jun;36(6):692-6
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  • [Title] Lipomatous apocrine mixed tumor of the skin: an unusual giant lesion occurring in the breast.
  • Cutaneous mixed tumors (MTs), also known as chondroid syringomas, usually arise as small nodules in the head and neck region.
  • We describe an unusual case of a giant MT measuring 9 cm in its greatest diameter, occurring as a slowly growing pedunculated mass on the breast of a 74-year-old woman.
  • Apart this unusual clinical presentation, another intriguing feature of tumor was the histological picture, being composed of an extensive mature fatty stromal component closely intermingling with the epithelial structures.
  • As adipocytes were variable in size and focally showed a lipoblast-like appearance, some tumor areas were reminiscent of a well-differentiated liposarcoma, lipoma-like.
  • Based on the histological features, the term 'lipomatous mixed tumor, apocrine type' was proposed for such a lesion.
  • Histogenetic considerations about the lipomatous stromal component of the tumor are provided.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology. Lipoma / pathology. Neoplasms, Complex and Mixed / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Alzheimer Disease / complications. Female. Humans

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  • (PMID = 19515050.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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25. Kim H, Nakaichi M, Itamoto K, Taura Y: Malignant mixed tumor in the salivary gland of a cat. J Vet Sci; 2008 Sep;9(3):331-3
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  • [Title] Malignant mixed tumor in the salivary gland of a cat.
  • The presence of a malignant mixed tumor, also known as a carcinosarcoma, in the salivary gland is very rare.
  • Such tumors, which are typically aggressive, are characterized by the presence of carcinomatous and sarcomatous components.
  • Histopathological analysis of the mass revealed that it was a malignant mixed tumor.
  • [MeSH-major] Adenocarcinoma / veterinary. Cat Diseases / pathology. Cat Diseases / radiography. Chondrosarcoma / veterinary. Salivary Gland Neoplasms / veterinary

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  • [Cites] AJNR Am J Neuroradiol. 1995 Sep;16(8):1733-5 [7502984.001]
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  • (PMID = 18716455.001).
  • [ISSN] 1229-845X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2811847
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31. Okuda H, Tei N, Shimizu K, Imazu T, Yoshimura K, Kiyohara H: Chondroid syringoma of the scrotum. Int J Urol; 2008 Oct;15(10):944-5
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  • [Title] Chondroid syringoma of the scrotum.
  • A 70-year-old Japanese man complained of a nodular, non-tender scrotal mass, which had been gradually increasing in size over the last 10 years.
  • Excisional biopsy of the scrotal specimen revealed chondroid syringoma, a very rare benign tumor, more likely to occur in the head and neck region.
  • This is the eighth such case reported, and is an important type of scrotal tumor.
  • [MeSH-major] Adenoma, Pleomorphic. Genital Neoplasms, Male. Scrotum

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  • (PMID = 19138288.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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32. Borman H, Deniz LM, Ertas NM, Arikan U, Colak A: Chondroid syringoma of the hand. Scand J Plast Reconstr Surg Hand Surg; 2009;43(5):291-3
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  • [Title] Chondroid syringoma of the hand.
  • Chondroid syringoma is a rare cutaneous tumour that usually arises in the head and neck region and is rarely seen on the hands; it is rarely malignant at sites other than the head and neck.
  • We present a 56-year-old man with a chondroid syringoma of the hand that clinically resembled a vascular tumour.

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  • (PMID = 19863434.001).
  • [ISSN] 1651-2073
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Gibson A, Mavrikakis I, Rootman J, Dolman P: Lacrimal gland pleomorphic adenomas with low-density zones resembling cystic change on computed tomography. Ophthal Plast Reconstr Surg; 2007 May-Jun;23(3):234-5
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  • [Title] Lacrimal gland pleomorphic adenomas with low-density zones resembling cystic change on computed tomography.
  • We report 2 cases of pleomorphic adenoma with unusual radiologic findings.
  • CT showed lacrimal gland masses dominated by low-density areas resembling cysts.
  • Pathology revealed the lesions to be pleomorphic adenomas with myxomatous and/or cartilaginous features.
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Cysts / radiography. Eye Neoplasms / radiography. Lacrimal Apparatus Diseases / radiography. Tomography, X-Ray Computed

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  • (PMID = 17519667.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Zhao X, Ren W, Yang W, Wang Y, Kong H, Wang L, Yan L, Xu G, Fei J, Fu J, Zhang C, Wang Z: Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. Int J Cancer; 2006 Feb 1;118(3):643-8
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  • [Title] Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice.
  • Pleomorphic adenoma gene 1 (PLAG1) was found frequently rearranged and activated in human salivary gland pleomorphic adenomas.
  • Ectopic overexpression of PLAG1 has been proposed to play a crucial role in tumorigenesis of salivary gland pleomorphic adenomas.
  • In this report, we show that the salivary gland tumors developed in PLAG1 transgenic mice share major histopathologic features with human pleomorphic adenomas.
  • It was found that beta-catenin, the key component of Wnt signaling pathway, was upregulated at transcriptional level in tumors developed in 3 independent transgenic mouse lines.
  • Immunohistochemical staining revealed that expression of beta-catenin as well as c-myc, downstream of beta-catenin in Wnt signaling pathway, was highly upregulated with overexpression of PLAG1 transgene in tumor and normal transgenic salivary gland tissues.
  • Our findings provide the first in vivo evidence for the oncogenic activity of PLAG1 in pleomorphic adenoma tumorigenesis, reveal a valued animal model for human salivary gland tumors and suggest that Wnt signaling pathway may also contribute to the development of pleomorphic adenomas in transgenic mice.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. DNA-Binding Proteins / physiology. Proto-Oncogene Proteins c-myc / metabolism. Salivary Gland Neoplasms / genetics. Signal Transduction. Wnt Proteins / metabolism. beta Catenin / metabolism

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16108035.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Myc protein, mouse; 0 / PLAG1 protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / Wnt Proteins; 0 / beta Catenin
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35. Kazakov DV, Belousova IE, Bisceglia M, Calonje E, Emberger M, Grayson W, Hantschke M, Kempf W, Kutzner H, Michal M, Spagnolo DV, Virolainen S, Zelger B: Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases. J Am Acad Dermatol; 2007 Sep;57(3):467-83
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  • [Title] Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases.
  • BACKGROUND: A systematic analysis of the entire spectrum of various forms of differentiation and metaplastic epiphenomena in cutaneous apocrine mixed tumor (AMT) has never been performed.
  • OBJECTIVE: The purpose of our study was to study a large number of cutaneous mixed tumors so as to fully characterize the entire spectrum of differentiations and metaplastic changes that may occur in the epithelial, myoepithelial, and stromal components of AMT.
  • Stromal alterations included chondroid metaplasia, osseous metaplasia, and adipose metaplasia.
  • We propose that the most appropriate name for these lesions is "mixed tumor of the folliculosebaceous-apocrine complex. "
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Apocrine Glands. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17707152.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 104
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36. Nazarian Y, Talmi YP, Wolf M, Horowitz Z, Bedrin L, Pfeffer R, Kronenberg J: [Recurrent pleomorphic adenomas of the parotid gland--treatment and outcome]. Harefuah; 2007 Feb;146(2):82-4, 168
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  • [Title] [Recurrent pleomorphic adenomas of the parotid gland--treatment and outcome].
  • Epithelial tumors of the parotid gland comprise 3% of head and neck tumors, and 70%-80% of those are benign.
  • Pleomorphic adenoma is the most common tumor of the parotid gland.
  • Recurrence rate of pleomorphic adenomas (RPAs) following superficial parotidectomy was reported to be as high as 4%, sometimes associated with inadequate surgical treatment of the primary tumor.
  • These tumors have a very slow growth rate, and a ten-year follow-up period is mandatory.
  • Two patients (10%) had permanent paresis of a single branch of the facial nerve.
  • Seventeen out of 20 patients (85%) treated were disease-free after a follow-up period of 5 years.
  • [MeSH-major] Adenoma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17352271.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
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37. Declercq J, Van Dyck F, Van Damme B, Van de Ven WJ: Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice. Int J Oncol; 2008 May;32(5):1041-7
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  • [Title] Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice.
  • The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including pleomorphic adenomas of the salivary glands.
  • MMTV-Cre-mediated targeted overexpression of PLAG1 in the salivary glands of double transgenic offspring mice, referred to as P1-MCre and P2-MCre mice, induced pleomorphic adenomas in this organ.
  • Igf2, a genuine PLAG1 target gene, was highly upregulated in those tumours as well as in human pleomorphic adenomas of the salivary glands.
  • Inactivation of Igf2 in P1-MCre mice leads to a significant delay in tumour development.
  • Since tumour development is not fully abrogated by inactivation of Igf2, other signalling pathways are likely to contribute to PLAG1-induced tumourigenesis as well.
  • In conclusion, we clearly demonstrate upregulation of several genes associated with Igf and Wnt signalling in PLAG1-induced pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. DNA-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic. Insulin-Like Growth Factor II / metabolism. Salivary Gland Neoplasms / metabolism. Signal Transduction / genetics. Wnt Proteins / metabolism

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  • (PMID = 18425330.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / IGF2 protein, mouse; 0 / Plag1 protein, mouse; 0 / Wnt Proteins; 67763-97-7 / Insulin-Like Growth Factor II
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38. Ito FA, Jorge J, Vargas PA, Lopes MA: Histopathological findings of pleomorphic adenomas of the salivary glands. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E57-61
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  • [Title] Histopathological findings of pleomorphic adenomas of the salivary glands.
  • OBJECTIVES: To describe the histopathological features of pleomorphic adenoma (PA) with special reference to the epithelial and mesenchymal components.
  • The stromal component was analyzed according to the presence of myxoid, hyaline, chondroid or calcified tissue.
  • RESULTS: Plasmacytoid cells were the most commonly found cellular type followed by fusiform and cuboidal cells.
  • Myxoid and chondroid stroma were the most frequently found mesenchymal-like tissue usually forming the so called myxochondroid stroma.
  • CONCLUSION: The knowledge of the immense variety of cells, architectures and morphological characteristics present in PA of the salivary gland is essential for a correct diagnosis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19179950.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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39. Dubb M, Michelow P: Cytologic features of chondroid syringoma in fine needle aspiration biopsies: a report of 3 cases. Acta Cytol; 2010 Mar-Apr;54(2):183-6
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  • [Title] Cytologic features of chondroid syringoma in fine needle aspiration biopsies: a report of 3 cases.
  • However, most clinicians prefer to diagnose suspected skin tumors by excisional biopsy as they are easily accessible, with the result that benign skin adnexal tumors are rarely encountered on FNA, often leading to misdiagnosis and mismanagement of patients.
  • We describe the cytologic features of chondroid syringoma in 3 cases in order to facilitate cytologic diagnosis of this lesion.
  • CASES: Three patients each presented with a mass lesion in the head and neck region and on FNA were diagnosed as having chondroid syringomas.
  • CONCLUSION: Knowledge of the cytologic features of chondroid syringoma will allow definitive diagnosis and correct management of the patient.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 20391975.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Horiuchi C, Tsukuda M, Taguchi T, Ishiguro Y, Okudera K, Inoue T: Correlation between FDG-PET findings and GLUT1 expression in salivary gland pleomorphic adenomas. Ann Nucl Med; 2008 Oct;22(8):693-8
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  • [Title] Correlation between FDG-PET findings and GLUT1 expression in salivary gland pleomorphic adenomas.
  • OBJECTIVE: One reason for the difficulty in accurate preoperative pathological diagnosis of major salivary gland tumors with fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) is the tendency of pleomorphic adenomas to have a high, standardized uptake value (SUV).
  • The expression of glucose transporter 1 (GLUT1) and the quantity of GLUT1 messenger RNA (mRNA) were analyzed in specimens of pleomorphic adenoma to identify whether GLUT1 is responsible for the increased glucose uptake in FDG-PET examinations of these tumors.
  • METHODS: Eighty salivary gland tumors resected at Yokohama City University Hospital were retrospectively investigated.
  • GLUT1 was immunohistochemically stained, and GLUT1 mRNA density was quantified using real-time polymerase chain reaction in 10 of 40 pleomorphic adenomas.
  • RESULTS: The pleomorphic adenomas stained positively for GLUT1, and there was significant correlation between the GLUT1 index and the SUV in FDG-PET.
  • CONCLUSIONS: GLUT1 is expressed in salivary gland pleomorphic adenomas.
  • This result suggests that GLUT1 plays an important role in increasing FDG uptake in salivary gland pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / radionuclide imaging. Fluorodeoxyglucose F18 / pharmacokinetics. Glucose Transporter Type 1 / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / radionuclide imaging

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  • (PMID = 18982472.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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41. Zhang X, Cairns M, Rose B, O'Brien C, Shannon K, Clark J, Gamble J, Tran N: Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland. Int J Cancer; 2009 Jun 15;124(12):2855-63
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  • [Title] Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland.
  • Genome-wide microRNA (miRNA) expression profiling of salivary gland pleomorphic adenomas revealed a distinct expression signature consisting largely of upregulated miRNAs compared with matched normal tissue.
  • This is the first study to examine changes in the miRNA milieu in pleomorphic adenoma, the most common salivary gland tumour.
  • These changes may be potential underlying mechanisms for the development of these benign tumours.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Biomarkers, Tumor / genetics. Gene Expression Regulation, Neoplastic. MicroRNAs / genetics. Salivary Gland Neoplasms / genetics

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  • [Copyright] Copyright 2008 UICC.
  • (PMID = 19347935.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / MicroRNAs; 0 / PLAG1 protein, human; EC 1.13.12.- / Luciferases
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42. Qureshi A: True malignant mixed tumor of parotid. J Coll Physicians Surg Pak; 2007 Nov;17(11):697-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] True malignant mixed tumor of parotid.
  • Carcinosarcoma is a rare malignant neoplasm of salivary glands that manifests both carcinomatous and sarcomatous components.
  • Specimen of a recurrent parotid tumor of a 55-year-old male was received for histopathology.
  • Diagnosis of a biphasic malignant neoplasm was made.
  • Morphology and immunohistochemical profile were consistent with carcinosarcoma i.e. true malignant mixed tumor.

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  • (PMID = 18070582.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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43. El Fakiri MM, Aderdour L, Nouri H, Hassani R, Maliki O, Raji A: [Pleomorphic adenoma of the nasal septum]. Rev Stomatol Chir Maxillofac; 2010 Jun;111(3):162-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic adenoma of the nasal septum].
  • INTRODUCTION: The pleomorphic adenoma is the most common benign neoplasm of primary salivary glands.
  • We report a case of pleomorphic adenoma of the nasal septum.
  • A facial CT-scan showed a heterogeneous tumor of the nasal septum obstructing the left nasal vestibule.
  • The biopsy analysis proved the histological characteristics of a pleomorphic adenoma, and was further confirmed by immunohistochemical study.
  • DISCUSSION: The treatment of nasal pleomorphic adenomas must take into account lesion localization, esthetic complications, and evolutionary potential of the lesions.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Nasal Septum / pathology. Nose Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20416914.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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44. Mebazaa A, Trabelsi S, Denguezli M, Sriha B, Belajouza C, Nouira R: Chondroid syringoma of the arm: an unusual localization. Dermatol Online J; 2006;12(1):14
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  • [Title] Chondroid syringoma of the arm: an unusual localization.
  • Chondroid syringoma (CS) is an uncommon, benign, sweat-gland tumor.
  • We present a case of a CS located in the right arm of a 43-year-old woman.
  • This tumor developed slowly over 8 years.
  • The diagnosis of CS was made by histopathological examination; it showed an abundant chondroid stroma intermingled with a fibro-adipoid tissue.
  • There was no recurrence after total excision of the tumor with a 2-year followup.
  • The unusual localization of chondroid syringoma made an accurate preoperative diagnosis difficult and diagnosis was achieved only by microscopy.
  • Surgical tumor excision remains the best therapeutic option to avoid relapses of this tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Arm. Sweat Gland Neoplasms / pathology

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  • (PMID = 16638382.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Stomeo F, Rocca PC, Bozzo C, Bianchini C, Meloni F, Pastore A: Laryngeal true malignant mixed tumor. Head Neck; 2009 Apr;31(4):556-60

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  • [Title] Laryngeal true malignant mixed tumor.
  • BACKGROUND: True malignant mixed tumor, also known as carcinosarcoma, is a salivary gland type malignant neoplasm, which is extremely rare, and only a few cases arising in the larynx have been previously reported.
  • METHODS AND RESULTS: We report a case of true malignant mixed tumor arising in the larynx of a 65-year-old woman successfully treated with surgery.
  • Histologically, the neoplasm was composed of variably mixed, neoplastic glandular, spindle, and chondroid tissues.
  • CONCLUSION: These results strengthen the hypothesis that these neoplasms may develop from a divergent differentiation of a totipotent, myoepithelial precursor cell.
  • [MeSH-major] Carcinosarcoma / pathology. Laryngeal Neoplasms / pathology. Mixed Tumor, Malignant / pathology

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  • (PMID = 18972426.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Biernat W: Lipomatous mixed tumor of the skin. Am J Dermatopathol; 2008 Jun;30(3):284-6
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  • [Title] Lipomatous mixed tumor of the skin.
  • An unusual tumor of the neck in a 56-year-old female is reported.
  • The tumor was composed of tubules and small cords of epithelial cells dispersed in the fibromyxoid and adipose stroma.
  • At the periphery, the tumor was not encapsulated and its border was intermingled with the subcutaneous fat.
  • Lack of decapitation secretion and the absence of long tubules suggested an eccrine origin; however, in some of the tumor areas, the cells showed brightly eosinophilic copious cytoplasm that may indicate an apocrine differentiation.
  • As an area of chondroid metaplasia was identified, the diagnosis of a mixed tumor was rendered.
  • This unusual type of skin adnexal neoplasm with unique relation of the epithelial component to the surrounding adipose tissue requires differentiation with the primary cutaneous and metastatic carcinomas.
  • [MeSH-major] Adipose Tissue / pathology. Head and Neck Neoplasms / diagnosis. Lipoma / pathology. Neoplasms, Complex and Mixed / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged. Neoplasm Metastasis / diagnosis

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  • (PMID = 18496435.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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47. Kusafuka K, Nakano K, Hiraki Y, Shukunami C, Nagatsuka H, Nagai N, Takemura T, Sakaguchi Y, Okazaki K, Kusafuka M, Hisha H, Ikehara S: Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas. Virchows Arch; 2005 Jan;446(1):34-40
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  • [Title] Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas.
  • Pleomorphic adenoma is the most common epithelial tumor in the salivary glands.
  • This tumor frequently exhibits "mesenchyme"-like components, including myxoid or chondroid areas.
  • Recently, using immunohistochemical techniques, we reported that cartilage-specific matrix protein, chondromodulin-I (ChM-I), was deposited on the inter-territorial matrix of the chondroid area in salivary pleomorphic adenomas and that ChM-I, which is also a strong angio-inhibitory factor, plays an important role in the avascular nature of the chondroid area and the chondroid formation in this type of tumor.
  • To elucidate which cells express ChM-I mRNA in pleomorphic adenomas, we examined the expression and localization of ChM-I mRNA in this type of tumor using an in situ hybridization technique.
  • Immunoreactivity for ChM-I was observed in the inter-territorial matrix of the chondroid area, especially around the lacunae, and in the cytoplasm of neoplastic myoepithelial cells of the myxoid element of pleomorphic adenomas.
  • On in situ hybridization analysis, strong signals for ChM-I mRNA were detected in the cytoplasm of the lacuna cells of the chondroid element, and moderate to marked signals were observed in the cytoplasm of the neoplastic myoepithelial cells of the myxoid element.
  • Signals for ChM-I mRNA were also seen in the cytoplasm of the spindle-shaped neoplastic myoepithelial cells in the transitional areas between the myxoid and chondroid elements of this tumor.
  • These findings indicate that lacuna cells and neoplastic myoepithelial cells express ChM-I mRNA and that mature ChM-I, which lacuna cells and neoplastic myoepithelial cells translate, is deposited in the chondroid matrix of pleomorphic adenomas.
  • In conclusion, lacuna cells and neoplastic myoepithelial cells express ChM-I mRNA ectopically in pleomorphic adenoma, and this plays an important role in chondroid formation and hypovascularity in this type of tumor.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Intercellular Signaling Peptides and Proteins / genetics. Membrane Proteins / genetics. RNA, Messenger / analysis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 15549376.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / RNA, Messenger; 136362-10-2 / LECT1 protein, human
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48. Turhan-Haktanir N, Sahin O, Bukulmez A, Demir Y: Chondroid syringoma in a child. Pediatr Dermatol; 2007 Sep-Oct;24(5):505-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma in a child.
  • Chondroid syringoma is a myxoid tumor of the skin, which has a reported incidence of <0.01% among primary skin tumors.
  • The majority of these tumors occur in the head and neck regions of adult males.
  • We present the first instance of chondroid syringoma in a child, which, to the best of our knowledge, has not been reported previously in the English language literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Nose Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17958797.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Nath AK, Kumari R, Thappa DM: Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. Indian J Dermatol Venereol Leprol; 2009 Nov-Dec;75(6):600-2
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  • [Title] Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution.
  • It may be associated with foci of various other appendageal tumors.
  • Histopathology revealed dermal lobules of ES with smaller foci of chondroid syringoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19915242.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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50. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review.
  • INTRODUCTION: Primary neoplasms of the external ear canal are rare, and 5% of these tumors are of glandular origin.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • An alternative theory holds that pleomorphic adenomas may well arise from ectopic salivary tissue present in the external ear canal.
  • These tumors are very rare and usually have a benign course.
  • In this report, we describe an unusual case of pleomorphic adenoma of the external auditory canal associated with chronic infection of the middle ear.
  • Subsequent biopsy and histologic examination revealed pleomorphic adenoma of the external ear canal, possibly with malignant elements.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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51. Helmstaedter V, Beutner D, Drebber U, Huttenbrink KB, Streppel M: [Multiple primary pleomorphic adenomas of the unilateral parotid gland]. Laryngorhinootologie; 2007 Jun;86(6):448-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple primary pleomorphic adenomas of the unilateral parotid gland].
  • [Transliterated title] Das unilaterale, primär multilokuläre pleomorphe Adenom der Ohrspeicheldrüse.
  • BACKGROUND: Classical lateral parotidectomy is the standard surgical procedure for the management of lateral lobe parotid pleomorphic adenomas in most clinical centres.
  • CASE: We report on a 20-year-old patient with multiple primary pleomorphic adenomas in the unilateral parotid gland, which preoperatively presented as a solitary tumour node.
  • CONCLUSION: Considering this case we focus on the distinctive surgical procedures for the management of parotid pleomorphic adenomas.
  • We work out, why lateral or even total parotidectomy are justified in the treatment of solitary palpable tumours and why we account lateral parotidectomy as the standard surgical procedure for the management of lateral lobe parotid pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Dissection. Humans. Magnetic Resonance Imaging. Male. Parotid Gland / pathology. Parotid Gland / surgery

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  • (PMID = 17219338.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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52. Karakus MF, Ozcan KM, Dere H: Endoscopic resection of pleomorphic adenoma of the nasal septum. Tumori; 2007 May-Jun;93(3):300-1
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  • [Title] Endoscopic resection of pleomorphic adenoma of the nasal septum.
  • Pleomorphic adenomas originating from the minor salivary glands are rare in the nasal cavity.
  • Total surgical excision is the preferred treatment for pleomorphic adenomas.
  • Endoscopic tumor removal produces less morbidity, reduces blood loss during surgery, decreases hospital stay, avoids external scars and excessive unnecessary resection, enables the surgeon to better visualize the tumor margins, and has a low recurrence rate.
  • However, only 3 pleomorphic adenomas of the nasal septum have been removed by the endoscopic approach to date.
  • In this paper we report on a case of pleomorphic adenoma of the nasal septum that was removed successfully by the endoscopic approach without any recurrences.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Endoscopy. Nasal Septum / surgery. Nose Neoplasms / surgery

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  • (PMID = 17679469.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 11
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53. Tokyol C, Aktepe F, Yavas BD, Yildiz H, Aycicek A: Chondroid syringoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):973-6
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  • [Title] Chondroid syringoma: a case report.
  • BACKGROUND: Chondroid syringoma is a benign skin adnexal tumor.
  • The reported incidence of chondroid syringoma among primary skin tumors is low and has been reported at 0.01-0.098%.
  • CASE: A 57-year-old woman presented with a 10-year history of a slowly growing lump on her philtrum.
  • A diagnosis of benign appendageal tumor of the skin was made.
  • Surgical excision of tumor was done.
  • Histopathologic examination was consistent with chondroid syringoma.
  • CONCLUSION: Chondroid syringoma should be included in the differential diagnosis of a slowly growing nodule on the head or neck.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lip Neoplasms / pathology

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  • (PMID = 21053580.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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54. Kasashima S, Hiroshi M, Toshinori M, Yoshio O: Lipomatous mixed tumor with follicular differentiation of the skin. J Cutan Pathol; 2006 May;33(5):389-94
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  • [Title] Lipomatous mixed tumor with follicular differentiation of the skin.
  • A very rare case of cutaneous mixed tumor with numerous adipose tissue and hair follicular structures in a 67-year-old Japanese male was reported.
  • A well-circumscribed tumor was in the subcutaneous tissue of the cheek and far from the parotid gland.
  • Histologically, the tumor consisted of an admixture of the adipose tissue, fibromyxoid tissue with spindle cells, and branching tubular structures.
  • Outer layers of ductal epithelial cells and single spindle cells were often in a transition, likely as typical mixed tumor.
  • No chondroid stroma was seen.
  • To our knowledge, this tumor is the first case of a lipomatous mixed tumor with hair follicular differentiation.
  • The case indicates an additional wide spectrum of histologic appearances of cutaneous mixed tumor.
  • [MeSH-major] Adipose Tissue / pathology. Hair Follicle / pathology. Mixed Tumor, Malignant / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Apocrine Glands / pathology. Biomarkers, Tumor / analysis. Hair Diseases / metabolism. Hair Diseases / pathology. Humans. Immunohistochemistry. Male

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  • (PMID = 16640549.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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55. Gedlicka C, Item CB, Wögerbauer M, Martinek H, Heiduschka G, Erovic BM, Ch Grasl M, Thurnher D: Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations. J Surg Oncol; 2010 Feb 1;101(2):127-30
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  • [Title] Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations.
  • BACKGROUND AND OBJECTIVES: This retrospective study was performed to evaluate the status of p53 in pleomorphic adenomas and carcinomas ex pleomorphic adenoma in the parotid gland.
  • As loss or mutation of p53 can cause malignant transformation, the possible degeneration of pleomorphic adenomas to carcinomas ex pleomorhic adenoma was investigated by mutational analysis.
  • METHODS: Twenty-five Patients including 14 patients with pleomorphic adenomas and 11 patients with carcinoma ex pleomorphic adenoma of the parotid gland were examined for p53 status.
  • Denaturing gradient gel electrophoresis (DGGE) was carried out for mutational analysis and DNA sequencing was performed in case of a suspected mutation.
  • RESULTS: Fourteen pleomorphic adenomas and 11 carcinomas ex pleomorphic adenoma were screened for p53 status and potent mutations.
  • CONCLUSION: We could not detect mutations of p53 neither in benign nor malignant parotid tumors and we therefore assume that p53 plays no role in the transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Genes, p53 / genetics. Parotid Neoplasms / genetics

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  • (PMID = 19950209.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Choudhury M, Agarwal C, Aggarwal M, Pathania OP, Goel N: Clinicopathological profile of an unusual case of chondroid syringoma: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):349-51
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  • [Title] Clinicopathological profile of an unusual case of chondroid syringoma: a case report.
  • Chondroid syringoma or mixed tumor of the skin is an uncommon tumor that typically presents as small, solitary, slow growing, firm, subcutaneous or intracutaneous nodule.
  • FNAC and excision biopsy revealed benign chondroid syringoma.
  • This is a rare case of chondroid syringoma exhibiting large size, multiplicity and unusual locations in flank, chest wall and thigh.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17883069.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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57. Sirivella S, Gielchinsky I: Chondroid syringoma: a rare tumor of the chest wall. Ann Thorac Surg; 2010 Mar;89(3):983-5
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  • [Title] Chondroid syringoma: a rare tumor of the chest wall.
  • Chondroid syringoma, an uncommon, slow-growing, benign, sweat-gland tumor located on the upper right chest wall of a 66-year-old woman is presented.
  • This skin adenexal tumor is typically located on the head and neck region.
  • The unusual location of chondroid syringoma made an accurate preoperative diagnosis difficult, and diagnosis was achieved only by excisional biopsy and histopathologic examination.
  • Total surgical excision remains the best therapeutic option to avoid tumor recurrence and close follow-up is recommended because of a rare possibility of malignant transformation and visceral metastases.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172178.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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58. Tarakji B, Nassani MZ: Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types). Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e697-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types).
  • OBJECTIVE: Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma.
  • STUDY DESIGN: A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
  • RESULTS: The results showed that p21 expression was negative in the most components of normal tissue of the salivary gland surrounding pleomorphic adenoma, 24 cases out of 29 of the non tumour duct cells (82.8%), and 28 (96.6%) cases out of 29 of the acinar cells shows negative p21 expression.
  • P21 expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells. p21 was strongly expressed in carcinoma cells in 9 (33.3%) cases out of 27.
  • CONCLUSION: Our data suggest that the strong nuclear staining as an indicator for altered p21, then the alteration of p21 expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 33.3%).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis. Salivary Gland Neoplasms / metabolism. Salivary Glands / metabolism

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  • (PMID = 20383106.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21
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59. Shimoyama Y, Yamashita K, Ohmachi T, Akihara Y, Sako T, Hirayama K, Okamoto M, Taniyama H: Pleomorphic adenoma of the salivary gland in two dogs. J Comp Pathol; 2006 Feb-Apr;134(2-3):254-9
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  • [Title] Pleomorphic adenoma of the salivary gland in two dogs.
  • Pleomorphic adenomas of the salivary gland were diagnosed in two dogs.
  • Labelling for GFAP indicated stromal transformation into myxoid and chondroid tissues.
  • [MeSH-major] Adenoma, Pleomorphic / veterinary. Dog Diseases / pathology. Parotid Neoplasms / veterinary. Sublingual Gland Neoplasms / veterinary
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Disease-Free Survival. Dogs. Immunoenzyme Techniques / veterinary. Male. Salivary Glands / pathology. Salivary Glands / surgery

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  • (PMID = 16542673.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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60. Molina EJ, Mayer K, Khurana J, Grewal H: Pleomorphic adenoma of the submandibular gland. J Pediatr Surg; 2008 Jun;43(6):1224-6
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  • [Title] Pleomorphic adenoma of the submandibular gland.
  • Pleomorphic adenomas of the submandibular glands are exceedingly rare tumors in the pediatric practice.
  • Radiologic studies are usually unable to differentiate benign from malignant tumors in most cases.
  • Recurrences are rare with complete en bloc excision of the tumor and the submandibular gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 18558215.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • [Title] Chondroid syringoma of the hand: a rare localization.
  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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62. Tarakji B, Nassani MZ: Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons. Kulak Burun Bogaz Ihtis Derg; 2010 May-Jun;20(3):129-36
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  • [Title] Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons.
  • OBJECTIVES: This study aims to highlight the current points of view regarding the management of pleomorphic adenomas among oral and maxillofacial surgeons in the United Kingdom.
  • The survey evaluated the surgical experience of the surgeon, the preferred surgical treatment of a newly diagnosed 3 cm diameter pleomorphic adenoma in the superficial lobe of the parotid gland in an adult and a child, and the treatment options of pleomorphic salivary adenoma (PSA) with the four following scenarios: (i) PSA with complete excision or incomplete excision;.
  • (ii) PSA with carcinoma in situ (atypical pleomorphic adenoma) with complete excision or incomplete excision;.
  • The results showed that there was no significant difference in the opinions of the respondents regarding treatment of pleomorphic adenoma in both adults and children.
  • There was a consensus on complete excision for the treatment of carcinoma in situ (atypical pleomorphic adenoma) or PSA with non-invasive malignant transformation.
  • CONCLUSION: This survey shows that superficial parotidectomy is the standard treatment method for primary pleomorphic adenoma in children and adults.
  • Surgery combined with radiotherapy is the preferred option in the case of multinodular recurrence, and surgery alone is recommended in the case of a solitary recurrence.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Health Care Surveys. Parotid Neoplasms / surgery
  • [MeSH-minor] Adult. Child. Combined Modality Therapy. Data Collection. Great Britain. Humans. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Otolaryngology. Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery. Societies, Medical. Surgical Procedures, Operative / methods

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  • (PMID = 20465538.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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63. Kumar B: Chondroid syringoma diagnosed by fine needle aspiration cytology. Diagn Cytopathol; 2010 Jan;38(1):38-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma diagnosed by fine needle aspiration cytology.
  • Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region.
  • It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components.
  • There are only few case reports describing the fine needle aspiration cytologic features of chondroid syringoma for diagnosis.
  • On the basis of these cytologic features, a diagnosis of chondroid syringoma was made.
  • We concluded that Chondroid syringoma may be considered as a rare differential diagnosis in the swelling of head and neck region and the diagnosis can be easily confirmed or ruled out by means of fine needle aspiration cytology.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19693940.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Swelam W, Ida-Yonemochi H, Maruyama S, Ohshiro K, Cheng J, Saku T: Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma. Virchows Arch; 2005 Jun;446(6):653-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma.
  • To better understand the poorly vascularized background of the stroma of pleomorphic adenomas, we attempted to determine the expression of molecules related to blood vessels and hypoxic conditions in pleomorphic adenoma.
  • Surgical specimens and tumor cells in primary culture of salivary pleomorphic adenomas were used for immunohistochemistry for CD31, vascular endothelial growth factor (VEGF) and its receptors Flk-1 and Flt-1, as well as for hypoxia markers, such as hypoxia-inducible factor-1alpha (HIF-1alpha) and lactate dehydrogenase-1 (LDH).
  • In addition to co-immunolocalization with CD31+ vascular endothelial cells, VEGF and its receptors were demonstrated in normal duct epithelial and myoepithelial cells as well as in tumor cells in ductal structures and in myxochondroid stromata.
  • Immunofluorescence signals for VEGF and others were confirmed in pleomorphic adenoma cells in culture.
  • RT-PCR results showed that there were at least four splicing modes of the VEGF gene, among which VEGF(121) was most enhanced, and higher HIF-1alpha levels in pleomorphic adenomas.
  • The results suggest that pleomorphic adenoma cells produce VEGF in several functional forms for their own proliferation or differentiation, and that the VEGF expression is controlled by hypoxic circumstances of poorly vascularized pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Anoxia / physiopathology. Salivary Gland Neoplasms / blood supply. Vascular Endothelial Growth Factor A / genetics. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Alternative Splicing. Antigens, CD31 / metabolism. Biomarkers, Tumor / analysis. Fluorescent Antibody Technique. Humans. Hypoxia-Inducible Factor 1, alpha Subunit. Image Processing, Computer-Assisted. Immunohistochemistry. Proteins / metabolism. RNA, Messenger / analysis. Receptor Protein-Tyrosine Kinases / metabolism. Receptor, Fibroblast Growth Factor, Type 1. Receptors, Fibroblast Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors / metabolism. Vascular Endothelial Growth Factor Receptor-1

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  • (PMID = 15856293.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Proteins; 0 / RNA, Messenger; 0 / Receptors, Fibroblast Growth Factor; 0 / Transcription Factors; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / FLT1 protein, human; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1
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65. Currie ZI, Rose GE: Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol; 2007 Dec;125(12):1643-6
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  • [Title] Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland.
  • OBJECTIVE: To ascertain the need for follow-up after excision of pleomorphic adenoma of the lacrimal gland.
  • METHODS: Medical records were reviewed for 133 patients and only those patients with 5 years or more of follow up were classified into the following 5 subgroups: those with intact excision (group IA, n = 46), those with surgically intact excision but areas of complete attenuation of the pseudocapsule at histologic analysis (group IB, n = 7), those with previous inadvertent incisional biopsy (group IIA, n = 9), those with breach of the pseudocapsule during attempted intact excision (group IIB, n = 5), and those undergoing definitive surgery because of tumor recurrence after previous incomplete excision (group III, n = 5).
  • RESULTS: Seventy-two patients were followed up longer than 5 years; there were no known tumor recurrences among 61 patients excluded with shorter follow-up.
  • Patients in groups IA and IB exhibited no tumor recurrences at 8.2 to 34.1 years of follow-up.
  • A benign recurrence occurred along the superior orbital fissure in 1 patient in group IIA 12(1/2) years after the initial surgery and was resected.
  • CONCLUSIONS: Discharge would seem justified after intact excision of lacrimal gland pleomorphic adenoma, even when histologic examination shows extreme attenuation of the pseudocapsule.
  • Long-term follow-up is, however, necessary when there has been tumor disruption, either inadvertently during previous biopsy or by capsular breach during definitive excision.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 18071115.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Ascani G, Messi M, Balercia P: [Surgical management of pleomorphic adenoma of the salivary glands: our experience]. G Chir; 2008 Aug-Sep;29(8-9):343-6
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  • [Title] [Surgical management of pleomorphic adenoma of the salivary glands: our experience].
  • [Transliterated title] Trattamento dell'adenoma pleomorfo delle ghiandole salivari: nostra esperienza.
  • BACKGROUND: Pleomorphic adenoma is a benign epithelial tumour of adenoid structure preferentially arising from the parotid gland.
  • AIM: To analyse the outcome of patients with pleomorphic adenoma from salivary glands in order to evaluate the surgical strategy.
  • PATIENTS AND METHODS: This is an audit of a 15-year period where 347 pleomorphic adenomas of the salivary glands were treated by the authors.
  • RESULTS: The pleomorphic adenoma preferentially originated in the parotid gland (89.1%), and rarely in other glands.
  • The tumour occurred more often in females than in males (F:M=1.5).
  • CONCLUSION: The epidemiological aspects of pleomorphic adenoma of salivary glands retrieved in our study are similar to those reported in literature; moreover this study demonstrates that pericapsular enucleation is a viable alternative to superficial parotidectomy for the majority of parotid localizations, associated with reduced morbidity without oncological compromise.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 18834565.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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67. Genelhu MC, Gobbi H, Soares FA, Campos AH, Ribeiro CA, Cassali GD: Immunohistochemical expression of p63 in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. Oral Oncol; 2006 Feb;42(2):154-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of p63 in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands.
  • Alteration of the p63 protein expression has been associated with several human cancers including salivary gland tumors.
  • We sought to assess the p63 expression in pleomorphic adenomas (PA) and carcinoma ex-pleomorphic adenomas (Ca ex-PA), since this protein has been related to myoepithelial phenotype and the biological behavior of cancer.
  • Our data suggest that loss of myoepithelial differentiation is important in the evolution of Ca ex-PA, and corroborate the hypothesis that p63 antigen may be a useful marker of myoepithelial cells in salivary glands neoplasms.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Biomarkers, Tumor / metabolism. Carcinoma / metabolism. DNA-Binding Proteins / metabolism. Salivary Gland Neoplasms / metabolism. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Cell Differentiation. Disease Progression. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Transcription Factors

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  • (PMID = 16256413.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Neoplasm Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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68. Nistal M, Yébenes-Gregorio L, Esteban-Rodríguez I, Bernáldez R, Regadera J: Malignant mixed tumor of the larynx. Head Neck; 2005 Feb;27(2):166-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant mixed tumor of the larynx.
  • BACKGROUND: Malignant mixed tumor of the larynx is a very rare neoplasm; only five cases have been reported, three in the English-language literature.
  • METHODS: We report the case of a 69-year-old man with a 2-month history of hoarseness and a left laterocervical palpable mass.
  • The tumor involved the glottic and subglottic regions and thyroid cartilage and extended to the anterior side of the larynx.
  • Microscopically, the tumor was composed of three cellular types: epithelial cells, chondrocytes, and spindle cells.
  • The tumor metastasized to a cervical lymph node, with the three described components.
  • CONCLUSIONS: The lesion in this case was considered to be a malignant mixed tumor.
  • Differences between this tumor and that of laryngeal chondrosarcoma are discussed.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Mixed Tumor, Malignant / pathology

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  • [Copyright] 2005 Wiley Periodicals, Inc.
  • (PMID = 15641103.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Brunese L, Ciccarelli R, Fucili S, Romeo A, Napolitano G, D'Auria V, Collina A, Califano L, Cappabianca S, Sodano A: Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography. Dentomaxillofac Radiol; 2008 Dec;37(8):464-9
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  • [Title] Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography.
  • OBJECTIVES: To assess the efficacy of multiphasic CT with 8 min delayed acquisition in the differential diagnosis between pleomorphic adenomas and other parotid neoplasias.
  • RESULTS: On histological examination, 36 tumours were classified as pleomorphic adenomas and 26 as non-pleomorphic adenomas.
  • On the basis of a statistical comparison, the third phase proved to be the most effective in the differential diagnosis between pleomorphic adenoma and non-pleomorphic adenomas, both for the assessment of the degree of the enhancement (in this phase, strong enhancement showed a sensitivity of 61.11%, specificity of 100%, positive predictive value (PPV) of 100% and negative predictive value (NPV) of 53.33%) and, above all, for the homogeneity of the enhancement (in this phase, indeed, uniform enhancement showed sensitivity, specificity, PPV and NPV of 100%).
  • CONCLUSIONS: Our results seem to indicate that multiphasic CT with 8 min delayed acquisition allows the differential diagnosis between pleomorphic adenomas and other parotid neoplasias.
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Parotid Neoplasms / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19033432.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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70. Zhang X, Wang Y, Yamamoto G, Tachikawa T: Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic adenomas. Histopathology; 2009 Sep;55(3):250-60
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  • [Title] Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic adenomas.
  • AIMS: The balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is involved in the morphogenesis of normal salivary gland as well as in the mechanisms of tumour invasion and metastasis.
  • The role of MMPs and TIMPs in pleomorphic adenoma has not been elucidated sufficiently.
  • Our aim was to analyse the mRNA and protein expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the epithelium and stroma of pleomorphic adenoma and to evaluate their roles.
  • CONCLUSIONS: Our results provide preliminary evidence that stromal myoepithelium may be the primary source of MMPs and that the stroma has the potential to play a more important role than ductal epithelium in biological behaviour of pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Matrix Metalloproteinase 2 / genetics. Matrix Metalloproteinase 9 / genetics. Salivary Gland Neoplasms / genetics. Tissue Inhibitor of Metalloproteinase-1 / genetics. Tissue Inhibitor of Metalloproteinase-2 / genetics
  • [MeSH-minor] Adult. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Gene Expression. Humans. Male. Middle Aged. Parotid Gland / enzymology. Parotid Gland / pathology. Parotid Gland / surgery. RNA, Messenger / metabolism. Salivary Glands, Minor / enzymology. Salivary Glands, Minor / pathology. Salivary Glands, Minor / surgery. Stromal Cells / metabolism. Stromal Cells / pathology

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  • [ErratumIn] Histopathology. 2010 Feb;56(3):414. Wang, Yang [corrected to Wang, Yan]
  • (PMID = 19723139.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tissue Inhibitor of Metalloproteinase-1; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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71. Maruyama S, Cheng J, Yamazaki M, Liu A, Saku T: Keratinocyte growth factor colocalized with perlecan at the site of capsular invasion and vascular involvement in salivary pleomorphic adenomas. J Oral Pathol Med; 2009 Apr;38(4):377-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Keratinocyte growth factor colocalized with perlecan at the site of capsular invasion and vascular involvement in salivary pleomorphic adenomas.
  • BACKGROUND: Capsular invasion is often observed in daily pathologic diagnosis of pleomorphic adenomas, although neither actual information about its occurrence nor molecular mechanisms leading to their invasive activities have been reported.
  • In this study, our aim was to elucidate the mode and the frequency of capsular invasion in this tumor and to characterize the tumor cell arrangement at the site of capsular invasion.
  • METHODS: The mode and frequency of capsular invasion of salivary pleomorphic adenomas were histopathologically examined in 104 surgical specimens of pleomorphic adenoma, and stromal characteristics, and tumor cell arrangements at the sites of capsular invasion were immunohistochemically investigated.
  • The mode of capsular invasion was classified into two types: type I: intracapsular invasion (247 areas, 70%) and type II: capsular penetration (106 areas, 30%).
  • Myxoid stroma, which was perlecan-immunopositive (+), was shared by both type I and type II sites, while tumor cell foci containing ductal structures were predominant in type II sites.
  • In addition, apparent vascular involvement was recognized in 31 tumors (29.8%).
  • CONCLUSION: The results suggest that pleomorphic adenoma cells are able to invade into the capsule and involve blood vessels when they are situated in perlecan-rich milieu, which accelerate KGF signaling.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Fibroblast Growth Factor 7 / metabolism. Heparan Sulfate Proteoglycans / metabolism. Neoplasm Invasiveness / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Blood Vessels / pathology. Fibroblast Growth Factor 2 / metabolism. Humans. Immunoenzyme Techniques. Receptor, Fibroblast Growth Factor, Type 2 / metabolism. Signal Transduction. Stromal Cells / pathology

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  • (PMID = 19228276.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Heparan Sulfate Proteoglycans; 103107-01-3 / Fibroblast Growth Factor 2; 126469-10-1 / Fibroblast Growth Factor 7; 143972-95-6 / perlecan; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 2
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72. Genelhu MC, Gobbi H, Arantes DC, Cardoso SV, Cassali GD: Immunolocalization of beta-catenin in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. Appl Immunohistochem Mol Morphol; 2007 Sep;15(3):273-8
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  • [Title] Immunolocalization of beta-catenin in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands.
  • Change in beta-catenin distribution has been associated with several human cancers including salivary gland tumors.
  • We studied the immunolocalization of beta-catenin in a series of pleomorphic adenomas (PA) and carcinomas ex-pleomorphic adenomas (Ca ex-PA).
  • Cell membrane/cytoplasmic staining of beta-catenin was observed in normal gland parenchyma, PA, and in well-differentiated Ca ex-PA.
  • Our data showed decreased cell membrane beta-catenin expression in higher-grade tumors suggesting that beta-catenin may play an important role in histologic differentiation and transition to malignant phenotype of Ca ex-PA.

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  • (PMID = 17721271.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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73. Lin WC, Li CS, Lin CK, Hsu HH, Chang TH, Chen TY, Huang GS: Atypical pulmonary metastases from a true malignant mixed tumor of the parotid gland. Korean J Radiol; 2009 Mar-Apr;10(2):202-5
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  • [Title] Atypical pulmonary metastases from a true malignant mixed tumor of the parotid gland.
  • A 58-year-old male patient presented with a recurrent true malignant mixed tumor of the parotid gland.
  • This abnormality was confirmed to be the result of a metastatic true malignant mixed tumor by using CT-guided biopsy.
  • The current case demonstrated an extremely rare example of atypical pulmonary metastases from a true malignant mixed tumor of the parotid gland showing an air-space pattern and calcification.
  • [MeSH-major] Lung Neoplasms / secondary. Mixed Tumor, Malignant / pathology. Parotid Neoplasms / pathology

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  • [Cites] Arch Pathol Lab Med. 2001 Jun;125(6):812-5 [11371238.001]
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  • (PMID = 19270869.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2651446
  • [Keywords] NOTNLM ; Atypical pulmonary metastases / Computed tomography (CT) / Parotid gland, true malignant mixed tumor
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74. Kaushik V, Bhalla RK, Nicholson C, de Carpentier JP: The chondroid syringoma: report of a case arising from the external auditory canal. Eur Arch Otorhinolaryngol; 2005 Oct;262(10):868-70
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  • [Title] The chondroid syringoma: report of a case arising from the external auditory canal.
  • Chondroid syringoma is an uncommon, benign skin adnexal tumour.
  • A rare case of chondroid syringoma arising from the external auditory canal is reported.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ear Canal. Ear Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 15739085.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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75. Li ZL, Sun D, Kong CZ: [Diagnosis and treatment for the corticomedullary mixed tumor of adrenal gland]. Zhonghua Wai Ke Za Zhi; 2009 Aug 15;47(16):1239-41
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  • [Title] [Diagnosis and treatment for the corticomedullary mixed tumor of adrenal gland].
  • OBJECTIVE: To study and summarize the diagnosis and treatment for the corticomedullary mixed tumor of adrenal gland.
  • METHODS: The clinical data of 25 cases of adrenal corticomedullary mixed tumor from January 2000 to April 2008 were analyzed retrospectively, which including 9 males and 16 females.
  • All of the cases had blood pressure fluctuation during dissection of the adrenal tumors, with the highest blood pressure reached to 230/140 mm Hg (1 mm Hg = 0.133 kPa).
  • Postoperative histopathological study revealed that the pathological changes was corticomedullary mixed tumor of adrenal gland, which was supported by immunohistochemical study.
  • CONCLUSIONS: In cases with complex phenomenon that can't explain with single cortical or medullary changes, it must beware of the mixed pathological changes in adrenal gland.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / surgery

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  • (PMID = 19781172.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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76. Wong MH, Dobbins TA, Tseung J, Tran N, Lee CS, O'Brien CJ, Clark J, Rose BR: Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland. J Clin Pathol; 2009 Sep;62(9):789-93
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  • [Title] Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland.
  • AIMS: Pleomorphic adenomas of the salivary gland have gender and age distributions suggesting that oestrogen has a causal role.
  • However, oestrogen receptor (ER)alpha is expressed at low levels in normal salivary gland tissues and data from salivary gland tumours are conflicting.
  • There is preliminary evidence that the recently described ERbeta may be the major ER in salivary gland tissue.
  • The aim of this study was to determine the nature and extent of ERbeta expression in pleomorphic adenomas of the salivary gland.
  • METHODS: Pleomorphic adenomas and normal tissues of the parotid gland from 49 patients were tested for ERalpha and ERbeta expression by semiquantitative immunohistochemistry.
  • RESULTS: ERalpha and ERbeta expression was localised mainly to the nuclei of ductal cells in normal tissues and the epithelial components in pleomorphic adenomas.
  • Within each tissue and receptor type there were no associations between ER positivity and patient age or gender.
  • ERbeta was expressed in almost twice as many normal tissues and pleomorphic adenomas as ERalpha.
  • Expression of ERbeta was also significantly higher in tumour compared with normal tissues.
  • CONCLUSIONS: This is thought to be the first study of ERbeta in pleomorphic adenomas of the salivary gland.
  • Findings support ERbeta as the major ER in salivary glands, and provide evidence that ERbeta may have a role in the development of pleomorphic adenomas of the salivary gland.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Estrogen Receptor beta / metabolism. Parotid Neoplasms / metabolism
  • [MeSH-minor] Adult. Age Factors. Estrogen Receptor alpha / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Parotid Gland / metabolism. Sex Factors

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  • (PMID = 19734474.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Neoplasm Proteins
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77. Zheng YG, Zhao Y, Wu LY: [Metastasizing pleomorphic adenoma of the submandibular gland: a case report]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Jun;25(3):307-9

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  • [Title] [Metastasizing pleomorphic adenoma of the submandibular gland: a case report].
  • Metastasizing pleomorphic adenomas without histological evidence of malignancy have rarely been reported.
  • A case of 30-year-old woman with a mass which showed a benign pleomorphic adenoma appearanced histologically in the left submandibular gland and right supercollarbone respectively was described.
  • Eight years ago, the patient suffered from pleomorphic adenoma of the left submandibular gland.
  • It revealed histopathologic features consistent with the recurrent and metastasizing tumor.
  • The clinic pathological features, possible mechanism and prevention approach of metastasizing pleomorphic adenoma were discussed based on previously reports in the literature.
  • [MeSH-major] Parotid Neoplasms. Submandibular Gland
  • [MeSH-minor] Adenoma, Pleomorphic. Female. Humans. Salivary Gland Neoplasms

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  • (PMID = 17629216.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Salivary Gland Adenoma, Pleomorphic
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78. Malinvaud D, Couloigner V, Badoual C, Halimi P, Bonfils P: Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus. Auris Nasus Larynx; 2006 Dec;33(4):417-21
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  • [Title] Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus.
  • OBJECTIVES: Pleomorphic adenoma is the most common benign tumor of the major salivary glands, especially of the parotid gland.
  • It is much less common in the minor salivary glands of the oral cavity, and it rarely occurs in others sites in the head and neck.
  • Even if virus involvement in salivary glands tumor has been many times discuted, the etiology of this tumor keeps being unknown.
  • As compared to other nasal tumors, we tried to prove if Epstein-Barr virus (EBV) could be involved in the development of pleomorphic adenoma in this particular nasal localization.
  • METHODS: Three cases of pleomorphic adenomas of the nasal septum (two women and a man in age of 23-59 years) were retrospectively studied.
  • All the patients had undergone endoscopic surgery to remove the complete tumor.
  • We used hybridation technique in the search for EBV-DNA in the three tumors.
  • RESULTS AND CONCLUSION: We had positive EBV-DNA detection in the tumor in one case, which seemed to prove relationship between pleomorphic adenoma and this virus.
  • The literature concerning the subject is reviewed in order to explain EBV involvement in the development of such tumors in this particular localization.
  • [MeSH-major] Adenoma, Pleomorphic / virology. DNA, Viral / analysis. Herpesvirus 4, Human / isolation & purification. Nasal Septum / surgery. Salivary Gland Neoplasms / virology

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  • (PMID = 16895748.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / DNA, Viral
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79. Zbären P, Stauffer E: Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors. Head Neck; 2007 Aug;29(8):751-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors.
  • BACKGROUND: Histopathologic features of the capsule may have an impact on the recurrence rate of pleomorphic adenomas.
  • METHODS: Retrospective (n = 154) and prospective (n = 64) histologic analysis of the capsular characteristics such as incompleteness, tumor penetration, pseudopodia, and satellite tumors of 218 pleomorphic adenomas.
  • RESULTS: In 160 of the 218 (73%) pleomorphic adenomas, 1 or more capsular characteristics such as incomplete capsule (33%), capsule penetration (26%), pseudopodia (40%), and satellite nodules (13%) were detected.
  • Incomplete capsule and satellite tumors were most frequently seen in the stroma-rich (myxoid) subtype.
  • CONCLUSION: Pseudopodia and satellite tumors were more common than reported in the literature.
  • If left in the surrounding salivary gland tissue at surgery, they can lead to recurrences of pleomorphic adenomas of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17252593.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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80. Gao P, Zhou GY, Song XR, Hou JX, Zhang CJ, Ma C: [The relationship of abnormal expression of cell glucoprotein with recurrence of pleomorphic adenoma in salivary gland]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2005 Apr;23(2):164-6
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  • [Title] [The relationship of abnormal expression of cell glucoprotein with recurrence of pleomorphic adenoma in salivary gland].
  • OBJECTIVE: To study the relationship of expression of mucin 1 and E-cadherin with recurrence of pleomorphic adenoma in salivary gland, and to investigate the signal to predict the recurrence potential of the tumor.
  • METHODS: ; The capsule of tumor was observed by microscope.
  • The expression of mucin 1 and E-cadherin in 33 cases of primary adenoma, 12 cases of recurrent pleomorphic adenomas and 7 cases of malignant pleomorphic adenomas were detected by immunohistochemistry.
  • RESULTS: There was no significant difference about the status of capsule and the positive rate of mucin 1 expression between primary and recurrent pleomorphic adenoma (P > 0.05).
  • The abnormal distribution of mucin 1 expression was observed in recurrent pleomorphic adenoma (6/8), which was characterized by the positive staining of the whole cytomembrane.
  • On the other hand, positive staining of the primary pleomorphic adenoma was observed on the top of the membrane (19/21).
  • The staining pattern in malignant pleomorphic adenoma was similar with the recurrent ones except higher ratio of positive expression.
  • No significant different was observed among the three kind of tumors on the expression rate of E-cadherin (P > 0.05).
  • CONCLUSION: The status of capsule didn't have much actual usage in predicting the recurrence of pleomorphic adenoma.
  • There was no significant relationship between the expression of E-cd and the recurrence of the tumor.
  • The abnormal distribution of mucin 1 expression contributes to the invasiveness of the tumor and can be used as the predictive signal for recurrence of pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / physiopathology. Cadherins / metabolism. Mucin-1 / metabolism. Salivary Gland Neoplasms / physiopathology

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  • (PMID = 15952635.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins; 0 / Mucin-1
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81. Dumitriu D, Dudea SM, Botar-Jid C, Băciuţ G: Ultrasonographic and sonoelastographic features of pleomorphic adenomas of the salivary glands. Med Ultrason; 2010 Sep;12(3):175-83
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  • [Title] Ultrasonographic and sonoelastographic features of pleomorphic adenomas of the salivary glands.
  • AIMS: The typical ultrasound features of pleomorphic adenomas are considered to be the well-defined contour, the regular, sometimes lobulated shape, homogeneous structure and poor vascularization.
  • The goal of our study was to verify the validity of these features and to identify a typical sonoelastographic pattern for pleomorphic adenomas.
  • PATIENTS AND METHODS: Between April 2007 and February 2010, 70 salivary gland masses were examined prospectively (58 in the parotid gland, 12 in the submandibular gland).
  • RESULTS: Of the 70 tumors, 32 (45.7%) were pleomorphic adenomas, 12 (17.1%) Warthin tumors, 9 (12.8%) other benign tumors, 13 (18.5%) primary malignant tumors, 3 metastases from carcinoma, and 1 non-Hodgkin lymphoma.
  • Among pleomorphic adenomas, 15 (46.9%) were inhomogeneous, 7 (21.9%) contained necrotic areas and 14 (43.7%) were well-vascularized.
  • The lobulated contour was identified in 14 pleomorphic adenomas (43.7%), no other benign tumor presented this type of contour, but it was identified in 2 malignant tumors (15.3%).
  • On sonoelastography, most pleomorphic adenomas were heterogeneous.
  • The elastic component represented more than 50% of the tumor tissue in 22 cases (68.7%).
  • This aspect was also identified for 6 malignant tumors (46.1%).
  • CONCLUSIONS: Our results demonstrate that features such as heterogeneous structure, rich vascularization and intra-tumoral necrosis may be identified in a significant number of pleomorphic adenomas.
  • The most specific element in our group was the presence of a lobulated contour, which was not seen in any other benign tumor, but may rarely appear in certain malignant tumors.
  • The elastographic aspect was heterogeneous for most tumors, but the elastic composition identified in most pleomorphic adenomas was also present in a significant proportion of malignant tumors.
  • Therefore, a typical sonoelastographic pattern for pleomorphic adenomas could not be identified.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Elasticity Imaging Techniques / methods. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 21203593.001).
  • [ISSN] 1844-4172
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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82. Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, Soares J: PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. Mod Pathol; 2005 Aug;18(8):1048-55
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  • [Title] PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry.
  • Pleomorphic adenoma is the most common benign tumor of the salivary glands.
  • It has marked histological diversity with epithelial, myoepithelial and mesenchymal-type cells arranged in a variety of architectural and differentiation patterns.
  • Pleomorphic adenoma gene 1 (PLAG1), shown to be consistently rearranged in pleomorphic adenomas, is activated by chromosomal translocations involving 8q12, the chromosome region that is most frequently affected in these tumors.
  • In this study, we evaluated PLAG1 involvement in salivary gland tumorigenesis by determining the frequency of its alterations in a selected group of 20 salivary gland tumors: 16 pleomorphic adenomas and four carcinomas ex-pleomorphic adenoma, having in common the presence of karyotypic chromosome 8 deviations, either structural, with 8q12 rearrangements, or numerical, with gain of chromosome 8.
  • Except for one pleomorphic adenoma case (5%) that lacked PLAG1 involvement, 17 tumors (85%), (14 pleomorphic adenomas and three carcinomas ex-pleomorphic adenoma) showed intragenic rearrangements of PLAG1 and the remaining two cases (10%), (one pleomorphic adenoma and one carcinoma ex-pleomorphic adenoma), had chromosome trisomy 8 only.
  • To further investigate the role of PLAG1 on pleomorphic adenomas tumorigenesis, as well as the putative morphogenesis mechanism, we attempted to identify the cell types (epithelial vs myoepithelial) carrying 8q12/PLAG1 abnormalities by a combined phenotypic/genotypic analysis in four cases (three pleomorphic adenoma and one carcinoma ex-pleomorphic adenoma) characterized by 8q12 translocations and PLAG1 rearrangement.
  • This finding further supports the pluripotent single-cell theory, which postulates that the tumor-initiated, modified myoepithelial cell, evolves into the varied somatic cell phenotypes present in pleomorphic adenoma, and reinforces the role of PLAG1 on the tumorigenesis of benign and malignant pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. DNA-Binding Proteins / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 15920557.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human
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83. Pelaz AC, Llorente Pendás JL, Bueno GC, Suárez Nieto C: Simultaneous pleomorphic adenomas of the hard palate and parapharyngeal space. J Craniofac Surg; 2009 Jul;20(4):1298-9
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  • [Title] Simultaneous pleomorphic adenomas of the hard palate and parapharyngeal space.
  • We report a very unusual presentation of simultaneous pleomorphic adenomas of 2 different locations, hard palate and parapharyngeal space.
  • Patient age of presentation is rare because these tumors are seen in younger patients.
  • We treated a 70-year-old woman with these 2 tumors, resecting both lesions with intraoral and cervical approaches.
  • Pleomorphic adenomas are frequent lesions, but in the literature reviewed, we have not found articles reporting 2 simultaneous pleomorphic adenomas of these locations.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Neoplasms, Multiple Primary / surgery. Palatal Neoplasms / surgery. Pharyngeal Neoplasms / surgery

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  • (PMID = 19625855.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Bonet-Loscertales M, Armengot-Carceller M, Gaona-Morales J, Basterra-Alegría J: Multicentric recurrent parotid pleomorphic adenoma in a child. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e743-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicentric recurrent parotid pleomorphic adenoma in a child.
  • Mixed tumours of the parotid gland are rare in childhood and recurrence of this tumour is infrequent.
  • Also the first surgical treatment, tumour enucleation or parotidectomy, has been implicated as a cause for recurrence.
  • We present a case of a multicentric doubly recurrent parotid pleomorphic adenoma, 7 and 14 years after tumour enucleation, in a 9-year-old child.
  • All the nodules resected showed the hypocellular variant of pleomorphic adenoma.
  • We consider the relationships between the choice of treatment, the histologic subtypes of pleomorphic adenomas and multifocal tumours and recurrence.
  • We conclude that tumour enucleation is a risk factor for recurrence and total parotidectomy is the treatment of choice for pleomorphic parotid adenoma also in childhood.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20173712.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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85. Bento PM, Freitas Rde A, Pinto LP, de Souza LB: Tenascin and fibronectin in pleomorphic adenoma of the salivary gland. J Appl Oral Sci; 2006 Jun;14(3):198-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tenascin and fibronectin in pleomorphic adenoma of the salivary gland.
  • OBJECTIVES: To analyze the expression and distribution pattern of extracellular matrix components in pleomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case.
  • METHODS AND RESULTS: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies.
  • Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma.
  • Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma.
  • CONCLUSIONS: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.

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  • (PMID = 19089073.001).
  • [ISSN] 1678-7765
  • [Journal-full-title] Journal of applied oral science : revista FOB
  • [ISO-abbreviation] J Appl Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC4327197
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86. Skoro M, Ostović KT, Cikara I, Müller D, Novak NP, Virag M: Fine needle aspiration cytology of chondroid syringoma. Coll Antropol; 2010 Jun;34(2):687-90
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  • [Title] Fine needle aspiration cytology of chondroid syringoma.
  • Chondroid syringoma (CS) is a rare, benign, appendageal tumor with diagnostic feature of myxochondroid stroma supporting eccrine and apocrine epithelial structures.
  • It should be included in the differential diagnosis of cutaneous head and neck tumors, especially in middle-aged men.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Head and Neck Neoplasms / pathology

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  • (PMID = 20698155.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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87. Laspas F, Roussakis A, Papadopoulos S, Fanariotis I, Kritikos N, Kehagias D: Mixed tumor of the vagina: sonographic and magnetic resonance imaging findings. Ultrasound Obstet Gynecol; 2010 May;35(5):617-9
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  • [Title] Mixed tumor of the vagina: sonographic and magnetic resonance imaging findings.
  • Mixed tumor of the vagina is a rare benign neoplasm that is composed of epithelial and mesenchymal cells.
  • The majority of tumors are asymptomatic and simple tumor excision is curative.

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  • [Copyright] Copyright 2009 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 20069660.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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88. Giddings CE, Bray D, Rimmer J, Williamson P: Pleomorphic adenoma and severe obstructive sleep apnoea. J Laryngol Otol; 2005 Mar;119(3):226-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma and severe obstructive sleep apnoea.
  • Although minor salivary gland pleomorphic adenomas have been described as a cause of airway compromise, pleomorphic adenomata arising from the deep lobe of the parotid, causing proven obstructive sleep apnoea, have not previously been documented.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Parotid Neoplasms / complications. Sleep Apnea, Obstructive / etiology

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  • (PMID = 15845199.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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89. Urbaniec P, Namysłowski G, Lange D, Urbaniec N: [Pleomorphic adenoma of the nasal septum]. Otolaryngol Pol; 2005;59(3):425-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic adenoma of the nasal septum].
  • [Transliterated title] Gruczolak wielopostaciowy przegrody nosa.
  • The authors described the case of mixed salivary gland tumour in the nasal septum.
  • [MeSH-major] Adenoma, Pleomorphic. Nasal Septum / pathology. Nose Neoplasms

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  • (PMID = 16117402.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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90. Lee BH: Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space. Jpn J Radiol; 2010 Apr;28(3):224-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space.
  • Unilateral agenesis of the parotid gland is a rare condition.
  • Although pleomorphic adenomas are the most common benign glandular tumors of the buccal space, to the author's knowledge unilateral agenesis of the parotid gland associated with pleomorphic adenoma in the ipsilatearal buccal space has not been previously described in the literature.
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Cheek. Parotid Gland / abnormalities
  • [MeSH-minor] Aged. Female. Humans. Salivary Gland Neoplasms / radiography. Salivary Glands, Minor. Tomography, X-Ray Computed

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  • (PMID = 20437134.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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91. Rullo R, Festa VM, Accardo M, Ferraraccio F: The immunohistochemical outline of p27kip1, cyclin B1 and cyclin D3 in pleomorphic adenomas. Minerva Stomatol; 2006 Sep;55(9):483-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The immunohistochemical outline of p27kip1, cyclin B1 and cyclin D3 in pleomorphic adenomas.
  • AIM: Pleomorphic adenomas of salivary glands are benign lesions which may sometimes relapse even after complete surgical removal.
  • The authors intend to evaluate the degree of cellular aggression of these tumours by finding prognostic data using the antigens involved in cellular proliferative activity.
  • METHODS: Seventeen mixed tumours, 2 of them relapsed, underwent the direct immunohystochemical PAP technique for the determination of antigens p27kip1, cyclins B1 and D3 of the tissue.
  • CONCLUSIONS: On the basis of the results, the conclusion is drawn that there is no relation between the expressivity of the mentioned antigens and histological characters of pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / chemistry. Biomarkers, Tumor / analysis. Cyclin B / analysis. Cyclin-Dependent Kinase Inhibitor p27 / analysis. Cyclins / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 17146427.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CCNB1 protein, human; 0 / CCND3 protein, human; 0 / Cyclin B; 0 / Cyclin B1; 0 / Cyclin D3; 0 / Cyclins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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92. Kakitsubata Y, Theodorou SJ, Theodorou DJ, Nakahara M, Yuki Y, Yokouchi T: Giant chondroid syringoma presenting as a growing subcutaneous mass in the upper arm: MRI findings with pathologic correlation. Joint Bone Spine; 2009 Dec;76(6):711-4
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  • [Title] Giant chondroid syringoma presenting as a growing subcutaneous mass in the upper arm: MRI findings with pathologic correlation.
  • Chondroid syringoma of skin is a rare type of soft tissue tumor originating from the sweat glands.
  • We report a documented case of giant chondroid syringoma occurring in the upper arm, which developed over the course of one year.
  • The radiographic, sonographic, MR imaging, gross pathologic, and histologic findings of the tumor are described.
  • Because the clinical suggestion of such a tumor was low, we present the imaging appearances of chondroid syringoma that could be used to make a presumptive diagnosis, and discuss the many entertained differential diagnostic possibilities.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Magnetic Resonance Imaging / methods. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19793672.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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93. Ponce Bravo S, Ledesma Montes C, López Becerril U, Morales Sánchez I: Myoepithelial cells are the main component in pleomorphic adenomas? Med Oral Patol Oral Cir Bucal; 2007 Mar;12(2):E110-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myoepithelial cells are the main component in pleomorphic adenomas?
  • OBJECTIVE: The aim of this study was to quantify by immunohistochemistry the number of myoepithelial cells (MyECs) in pleomorphic adenomas (PAs).
  • The amount of S-100 protein positive cells was quantified, their morphology was recorded and comparison among MyEC number with age, gender and involved gland were also done.
  • RESULTS: With S-100 protein, MyECs in normal salivary gland tissue were seen surrounding the ductual structures only.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biomarkers, Tumor / analysis. Myoepithelioma / pathology. S100 Proteins / analysis. Salivary Gland Neoplasms / pathology

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  • (PMID = 17322797.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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94. Akbulut M, Zekioglu O, Terek MC, Ozdemir N: Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor. Arch Gynecol Obstet; 2008 Sep;278(3):283-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipoadenofibroma of the endometrium: a rare variant of benign mullerian mixed tumor.
  • OBJECTIVE: Adenofibroma is a form of mixed mesodermal tumor in which epithelial and stromal components are benign, and usually arises in the endometrium of postmenopausal women.
  • CONCLUSION: We suggest that uterine adenofibromas with lipomatous areas belong to the family of mixed tumor of Mullerian origin.
  • [MeSH-major] Adenofibroma / pathology. Endometrial Neoplasms / pathology. Mixed Tumor, Mullerian / pathology

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  • (PMID = 18236054.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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95. Kuroda N, Moriki T, Oguri H, Maeda N, Toi M, Miyazaki E, Hiroi M, Fukaya T, Enzan H: Malignant müllerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells. APMIS; 2005 Sep;113(9):643-6
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  • [Title] Malignant müllerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells.
  • Histologically, proliferation of undifferentiated neoplastic cells with marked cytological atypia predominated in the tumor.
  • A diagnosis of malignant müllerian mixed tumor (MMMT) was made.

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  • (PMID = 16218942.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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96. Cho NP, Han HS, Soh Y, Son HJ: Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. J Oral Pathol Med; 2007 May;36(5):297-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma.
  • Although COX-2 expression has been shown to be up-regulated in carcinomas of the salivary gland, its mechanisms are not completely understood.
  • METHODS: The expression of COX-2 and HuR was determined by immunohistochemistry in 28 cases of salivary pleomorphic adenoma and 18 cases of salivary mucoepidermoid carcinoma.
  • RESULTS: 28.6% and 72.2% of the pleomorphic adenomas and mucoepidermoid carcinomas showed high COX-2 expression respectively.
  • 35.7% of pleomorphic adenomas and 72.2% of mucoepidermoid carcinomas were tested positive for HuR in the cytoplasm of tumor cells.
  • There was a correlation between a high COX-2 immunoreactivity and cytoplasmic HuR expression in mucoepidermoid carcinomas but not in pleomorphic adenomas.
  • CONCLUSION: This study suggests that cytoplasmic HuR is correlated with COX-2 expression in salivary mucoepidermoid carcinomas.
  • In addition, the immunoreactivity of COX-2 and cytoplasmic HuR might be used to evaluate the nature of a borderline malignancy in the salivary glands.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Antigens, Surface / metabolism. Carcinoma, Mucoepidermoid / metabolism. Cyclooxygenase 2 / metabolism. Neoplasm Proteins / metabolism. RNA-Binding Proteins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17448140.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / ELAV Proteins; 0 / ELAV-Like Protein 1; 0 / ELAVL1 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Proteins; EC 1.14.99.1 / Cyclooxygenase 2
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97. Saad RS, Takei H, Lipscomb J, Ruiz B: Nodular fasciitis of parotid region: a pitfall in the diagnosis of pleomorphic adenomas on fine-needle aspiration cytology. Diagn Cytopathol; 2005 Sep;33(3):191-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodular fasciitis of parotid region: a pitfall in the diagnosis of pleomorphic adenomas on fine-needle aspiration cytology.
  • Fine-needle aspiration cytology (FNAC) is routinely employed for the preoperative diagnosis of salivary gland lesions.
  • Although most cases show morphologic features characteristic of specific entities, some lesions can be diagnostically challenging.
  • We report two parotid aspirates, initially diagnosed as pleomorphic adenoma on FNA.
  • The patients, a 33-yr-old white man, and a 24-yr-old white woman, presented with indurated lesions arising in the parotid gland region.
  • Smears showed a mixture of spindle cells with a well-demarcated cytoplasm showing occasional long cytoplasmic process; and cells with abundant cytoplasm with round to oval eccentric nuclei, giving the impression of plasmacytoid cells of pleomorphic adenoma.
  • Intermingled with the tumor cells were scattered neutrophils, eosinophils, and macrophages.
  • Aggregates of spindle cells were also seen embedded in a mucoid background with occasional small tufts of a fibrillar mucoid stroma.
  • These fibrillar tufts were magenta red in the Diff-Quik stain, giving the impression of matrix of pleomorphic adenoma.
  • Nodular fasciitis should be considered in the differential diagnosis of a mass arising in association with the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Fasciitis / pathology. Parotid Gland / pathology

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078254.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Roh JL, Park CI: Gland-preserving surgery for pleomorphic adenoma in the submandibular gland. Br J Surg; 2008 Oct;95(10):1252-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gland-preserving surgery for pleomorphic adenoma in the submandibular gland.
  • BACKGROUND: Removal of tumours arising in the submandibular gland (SMG) usually involves excision of the entire gland.
  • This prospective study evaluated the efficacy of gland-preserving surgery in patients with benign SMG tumours.
  • METHODS: Twenty consecutive patients with pleomorphic adenomas in the SMG underwent local excision of tumours with limited tumour-free margins and preservation of the remnant glandular tissues.
  • All patients had salivary scintigraphy before and 6 months after surgery, with ultrasonography 2 years after operation.
  • Complications, operating time, salivary function and rates of tumour recurrence were evaluated.
  • After surgery, the function of the affected gland was equal to that of the unaffected gland.
  • None of the patients had evidence of tumour recurrence on ultrasonographic examination and regular clinical examination at a median of 36 months after surgery.
  • CONCLUSION: Gland-preserving surgery in patients with benign SMG tumours preserves salivation, and reduces surgical morbidity and operating time, with good cosmesis but without compromising local control.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Submandibular Gland / surgery. Submandibular Gland Neoplasms / surgery

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  • (PMID = 18720459.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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99. Matsubayashi S, Yoshihara T: Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):789-95
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  • [Title] Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study.
  • The proliferative activity of the tumor cells and the expression of tumor-associated genes and sex steroid hormone receptors were investigated immunohistochemically in ten cases of carcinoma ex pleomorphic adenoma (Ca-ex-PA) of the salivary glands.
  • These were analyzed in benign and malignant components separately, and then were compared with ten cases of the other malignant tumors [adenocarcinomas, not otherwise specified (ACN) and salivary duct carcinomas (SDC)] and ten cases of pleomorphic adenomas (PA).
  • (1) malignant component of Ca-ex-PA showed a higher incidence of PCNA and Ki67 than benign component of Ca-ex-PA.
  • A significant difference between benign component of Ca-ex-PA and PA was not observed. (2) A significant difference in the incidence of p53, c-erbB-2, EGFR overexpression was observed only between malignant component of Ca-ex-PA and benign component of Ca-ex-PA. (3) The incidence of PCNA, Ki67, p53, c-erbB-2 overexpression in malignant component of Ca-ex-PA showed the highest data among the four groups.
  • These results suggest that Ca-ex-PA acquired the particular biological behavior in contrast to the other salivary neoplasms in the long-standing process while PA undergoes malignant transformation.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Antibodies, Neoplasm / immunology. Biomarkers, Tumor / immunology. Carcinoma, Ductal / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry / methods. Ki-67 Antigen / immunology. Ki-67 Antigen / metabolism. Male. Middle Aged. Neoplasm Recurrence, Local / immunology. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Proliferating Cell Nuclear Antigen / immunology. Proliferating Cell Nuclear Antigen / metabolism. Receptor, Epidermal Growth Factor / immunology. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / immunology. Receptor, ErbB-2 / metabolism. Receptors, Androgen / immunology. Receptors, Androgen / metabolism. Receptors, Estrogen / immunology. Receptors, Estrogen / metabolism. Retrospective Studies. Tumor Suppressor Protein p53 / immunology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17310348.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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100. Kakimoto N, Gamoh S, Tamaki J, Kishino M, Murakami S, Furukawa S: CT and MR images of pleomorphic adenoma in major and minor salivary glands. Eur J Radiol; 2009 Mar;69(3):464-72
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  • [Title] CT and MR images of pleomorphic adenoma in major and minor salivary glands.
  • PURPOSE: To investigate the CT and MR imaging features of pleomorphic adenoma in the head and neck area.
  • MATERIALS AND METHODS: Our materials of this study consisted of 50 pleomorphic adenomas from 50 patients which were all histopathologically diagnosed.
  • The following features were evaluated: the detectability of the lesion, the tumor margin, the border of the lesion, the aspect of the lesion, the contrast between the lesion and surrounding tissue, the signal intensity of the lesion, the enhancement of contrast medium, the aspect of the lesion after the injection of contrast medium, the detectability of the capsule, and the detectability of bone resorption of the lesion.
  • RESULTS: The tumor detectabilities were 77% on axial plain CT images and 90% on axial CE CT images, respectively.
  • On CT images, pleomorphic adenoma tended to show a well-defined margin, a smooth border, an inhomogeneous aspect, a low or high contrast, and intermediate or high signal intensity.
  • After contrast medium administration, pleomorphic adenoma tended to show a slightly high enhancement and either an inhomogeneous or a periphery enhancement on the CE CT images.
  • The tumor detectabilities were 86% on axial T1-weighted MR images, 88% on axial T2-weighted MR images, and 85% on axial CE T1-weighted MR images, respectively.
  • On MR images, pleomorphic adenomas tended to show well-defined margin, a lobulate border, an inhomogeneous aspect, a high contrast, and intermediate or high signal intensity.
  • After contrast medium administration, pleomorphic adenoma tended to show a high enhancement and either an inhomogeneous or a periphery enhancement on MR images.
  • CONCLUSIONS: It was possible to detect the capsule in pleomorphic adenoma using MR images.
  • The pleomorphic adenomas in head and neck area should be evaluated with MR images.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Magnetic Resonance Imaging / methods. Salivary Gland Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 18093776.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Ireland
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