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Items 1 to 100 of about 2021
1. Sun B, Li S, Yang L, Damodaran T, Desai D, Diehl AM, Alzate O, Koeberl DD: Activation of glycolysis and apoptosis in glycogen storage disease type Ia. Mol Genet Metab; 2009 Aug;97(4):267-71
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  • [Title] Activation of glycolysis and apoptosis in glycogen storage disease type Ia.
  • The deficiency of glucose-6-phosphatase (G6Pase) underlies glycogen storage disease type Ia (GSD-Ia, von Gierke disease; MIM 232200), an autosomal recessive disorder of metabolism associated with life-threatening hypoglycemia, growth retardation, renal failure, hepatic adenomas, and hepatocellular carcinoma.
  • Liver involvement includes the massive accumulation of glycogen and lipids due to accumulated glucose-6-phosphate and glycolytic intermediates.
  • Proteomic analysis revealed elevations in glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and other enzymes involved in glycolysis.
  • The moonlighting role of GAPDH includes increasing apoptosis, which was demonstrated by increased TUNEL assay positivity and caspase 3 activation in the murine GSD-Ia liver.
  • These analyses of hepatic involvement in GSD-Ia mice have implicated the induction of apoptosis in the pathobiology of GSD-Ia.
  • [MeSH-major] Apoptosis / genetics. Glycogen Storage Disease Type I / physiopathology. Glycolysis / genetics
  • [MeSH-minor] Animals. Glyceraldehyde-3-Phosphate Dehydrogenases / genetics. Liver / pathology. Mice

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  • (PMID = 19419892.001).
  • [ISSN] 1096-7206
  • [Journal-full-title] Molecular genetics and metabolism
  • [ISO-abbreviation] Mol. Genet. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases
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2. Abdel-Hamid MK, Abdel-Hafez AA, El-Koussi NA, Mahfouz NM, Innocenti A, Supuran CT: Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity. Bioorg Med Chem; 2007 Nov 15;15(22):6975-84
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  • A new series of 1,3,4-thiadiazole-2-thione derivatives have been prepared and assayed for the inhibition of three physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isozymes, the cytosolic human isozymes I and II, and the transmembrane, tumor-associated hCA IX.
  • Against hCA I the investigated thiones, showed inhibition constants in the range of 2.55-222 microM, against hCA II in the range of 2.0-433 microM, and against hCA IX in the range of 1.25-148 microM.
  • Compound 5c, 4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-1-(5-nitro-2-oxoindolin-3-ylidene)semicarbazide showed interesting inhibition of the tumor-associated hCA IX with K(I) value of 1.25 microM, being the first non-sulfonamide type inhibitor of such activity.

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  • (PMID = 17822907.001).
  • [ISSN] 0968-0896
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 1,3,4-thiadiazole-2-thione; 0 / Carbonic Anhydrase Inhibitors; 0 / Ligands; 0 / Thiadiazoles; 0 / Thiones; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.- / Carbonic Anhydrase IV
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3. Fisher SZ, Tu C, Bhatt D, Govindasamy L, Agbandje-McKenna M, McKenna R, Silverman DN: Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II. Biochemistry; 2007 Mar 27;46(12):3803-13
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  • Catalysis of the hydration of CO2 by human carbonic anhydrase isozyme II (HCA II) is sustained at a maximal catalytic turnover of 1 mus-1 by proton transfer between a zinc-bound solvent and bulk solution.
  • Correlating these structural variants with kinetic studies suggests that the very efficient proton transfer (approximately 7 micros-1) observed for Y7F HCA II in the dehydration direction, compared with the wild type and other mutants of this study, is due to a combination of three features.
  • Second, in the structure of Y7F HCA II, there is an unbranched chain of hydrogen-bonded waters linking the proton donor His64 and acceptor zinc-bound hydroxide.

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  • (PMID = 17330962.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM25154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons; 059QF0KO0R / Water; 142M471B3J / Carbon Dioxide; 4QD397987E / Histidine; EC 4.2.1.- / Carbonic Anhydrase II
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4. Hoban V: HCAs in nursing: what role should they play? Nurs Times; 2008 May 20-26;104(20):18-9
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  • [Title] HCAs in nursing: what role should they play?

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  • (PMID = 18546986.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Ji HF, Wang WL, Shen Y, Zhang M, Liang TB, Wu J, Xu X, Yan S, Zheng SS: Reduced-size liver transplantation for glycogen storage disease. Hepatobiliary Pancreat Dis Int; 2009 Feb;8(1):106-8
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  • [Title] Reduced-size liver transplantation for glycogen storage disease.
  • BACKGROUND: Glycogen storage disease (GSD) is an inherited metabolic disorder in which the concentration and/or structure of glycogen in tissues is abnormal.
  • Liver and muscle have abundant quantities of glycogen and are the most common and seriously affected tissues.
  • This study was to assess reduced-size liver transplantation for the treatment of GSD.
  • METHODS: The clinical data from one case of GSD type I with hepatic adenoma was retrospectively analyzed.
  • The clinical manifestations were hepatomegaly, delayed puberty, growth retardation, sexual immaturity, hypoglycemia, and lactic acidosis, which made the young female patient eligible for reduced-size liver transplantation.
  • RESULTS: The patient recovered uneventfully with satisfactory outcome, including 12 cm growth in height and 5 kg increase in weight during 16 months after successful reduced-size liver transplantation.
  • CONCLUSIONS: Reduced-size liver transplantation is an effective treatment for GSD with hepatomegaly and hepatic adenoma.
  • [MeSH-major] Adenoma, Liver Cell / surgery. Glycogen Storage Disease Type I / surgery. Liver Neoplasms / surgery. Liver Transplantation / methods


6. Ali K, Lu Y, Christensen C, May T, Hyett C, Griebel R, Fourney D, Meguro K, Resch L, Sharma RK: Fourier transform infrared spectromicroscopy and hierarchical cluster analysis of human meningiomas. Int J Mol Med; 2008 Mar;21(3):297-301
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  • [Title] Fourier transform infrared spectromicroscopy and hierarchical cluster analysis of human meningiomas.
  • Limitations of conventional light microscopy in pathological diagnosis of brain tumors include subjective bias in interpretation and discordance of nomenclature.
  • Spectral datasets were subjected to hierarchical cluster analyses (HCA) using Ward's algorithm for comparison and grouping of similar data groups, and were converted into color-coded digital maps for matching spectra with their respective clusters.
  • False color images of 5 and 6 clusters obtained by HCA identified dominant clusters corresponding to tumor tissue.
  • [MeSH-major] Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Meningioma / diagnosis. Meningioma / pathology
  • [MeSH-minor] Aged. Cluster Analysis. Female. Humans. Male. Middle Aged. Spectroscopy, Fourier Transform Infrared

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  • (PMID = 18288376.001).
  • [ISSN] 1107-3756
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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7. Guo W, He MC, Yang ZF, Lin CY, Quan XC: Occurrence of aliphatic hydrocarbons in water, suspended particulate matter and sediments of Daliao River system, China. Bull Environ Contam Toxicol; 2010 May;84(5):519-23
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  • Hierarchical cluster analysis (HCA) of aliphatic hydrocarbons is correspondence with hydrocarbons indexes results.
  • [MeSH-major] Air Pollutants / analysis. Alkanes / analysis. Geologic Sediments / chemistry. Industrial Waste / analysis. Particulate Matter / analysis. Rivers / chemistry

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  • (PMID = 20411239.001).
  • [ISSN] 1432-0800
  • [Journal-full-title] Bulletin of environmental contamination and toxicology
  • [ISO-abbreviation] Bull Environ Contam Toxicol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Alkanes; 0 / Industrial Waste; 0 / Particulate Matter
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8. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M: High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol; 2005 Mar;43(3):411-9
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  • We investigated the ability of Garcinia cambogia extract containing (-)-hydroxycitric acid (HCA) to suppress body fat accumulation in developing male Zucker obese (fa/fa) rats.
  • Diets containing different levels of HCA (0, 10, 51, 102 and 154 mmol/kg diet) were fed to 6-week-old rats for 92 or 93 days.
  • Each diet group was pair-fed to the 154 mmol HCA/kg diet group.
  • The highest dose of HCA-containing Garcinia cambogia (154 mmol HCA/kg diet) showed significant suppression of epididymal fat accumulation in developing male Zucker obese rats, compared with the other groups.
  • However, the diets containing 102 mmol HCA/kg diet and higher (778 and 1244 mg HCA/kg BW/d, respectively) caused potent testicular atrophy and toxicity, whereas diets containing 51 mmol HCA/kg diet (389 mg HCA/kg BW/d) or less did not.
  • Accordingly, 51 mmol HCA/kg diet (389 mg HCA/kg BW/d) was deemed to be the no observed adverse effect level (NOAEL).
  • [MeSH-minor] ATP Citrate (pro-S)-Lyase / metabolism. Animals. Anti-Obesity Agents / toxicity. Dose-Response Relationship, Drug. Leptin / blood. Liver / drug effects. Liver / enzymology. Liver / metabolism. Male. No-Observed-Adverse-Effect Level. Organ Size / drug effects. Random Allocation. Rats. Rats, Zucker. Testosterone / blood

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  • [CommentIn] Food Chem Toxicol. 2005 Nov;43(11):1683-4; author reply 1685-6 [15993998.001]
  • (PMID = 15680676.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Obesity Agents; 0 / Citrates; 0 / Leptin; 0 / Plant Extracts; 3XMK78S47O / Testosterone; 8W94T9026R / hydroxycitric acid; EC 2.3.3.8 / ATP Citrate (pro-S)-Lyase
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9. Kühnel D, Taugner F, Scholtka B, Steinberg P: Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats. Arch Toxicol; 2009 Aug;83(8):763-8
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  • Heterocyclic aromatic amines (HCAs) are formed in meat cooked at high temperatures for a long time or over an open flame.
  • In this context 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant HCA in cooked meat, has been suggested to be involved in colon and prostate carcinogenesis.

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  • (PMID = 19212758.001).
  • [ISSN] 1432-0738
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 2-amino-1-methyl-6-phenyl-1H-imidazo(4,5-b)pyridine; 0 / Aminopyridines; 0 / Carcinogens; 0 / Imidazoles
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10. Girard H, Butler LM, Villeneuve L, Millikan RC, Sinha R, Sandler RS, Guillemette C: UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans. Mutat Res; 2008 Sep 26;644(1-2):56-63
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  • Glucuronidation by the UDP-glucuronosyltransferase enzymes (UGTs) is one of the primary detoxification pathways of dietary heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs).
  • In a population-based case-control study of 537 cases and 866 controls, we investigated whether colon cancer was associated with genetic variations in UGT1A1 and UGT1A9 genes and we determined if those variations modify the association between colon cancer and dietary HCA and PAH exposure.
  • This finding is also supported by haplotype analyses where the UGT1A1-3279G-allele-bearing haplotype is overrepresented in case group.

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  • (PMID = 18675828.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK034987; United States / NCI NIH HHS / CA / R01 CA66635; United States / NCI NIH HHS / CA / R01 CA066635; United States / NICHD NIH HHS / HD / K12 HD051958; United States / NIDDK NIH HHS / DK / P30 DK034987-23; United States / NICHD NIH HHS / HD / 5K12HD051958; United States / NCI NIH HHS / CA / R01 CA066635-09; United States / NIDDK NIH HHS / DK / P30 DK34987
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Heterocyclic Compounds; 0 / Polycyclic Hydrocarbons, Aromatic; EC 2.4.1.- / UGT1A1 enzyme; EC 2.4.1.17 / Glucuronosyltransferase; EC 2.4.1.17 / UDP-glucuronosyltransferase 1A9
  • [Other-IDs] NLM/ NIHMS66700; NLM/ PMC2570038
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11. Rimkus C, Martini M, Friederichs J, Rosenberg R, Doll D, Siewert JR, Holzmann B, Janssen KP: Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer. Br J Cancer; 2006 Nov 20;95(10):1419-23
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  • The other members of this family are expressed mainly in haematopoietic cells, whereas SASH1 shows ubiquitous expression.
  • Moreover, nine benign adenomas and 10 liver metastases were analysed.
  • Expression levels of SASH1 were strongly and significantly reduced in colon cancer of UICC stage II, III, and IV, as well as in liver metastases.
  • Moreover, SASH1 was also found to be downregulated on protein levels by immunoblot analysis.
  • However, SASH1 expression was not significantly deregulated in precancerous adenomas and in earlier stage lesions (UICC I).
  • Downregulation of SASH1 expression was correlated with the formation of metachronous distant metastasis, and multivariate analysis identified SASH1 downregulation as an independent negative prognostic parameter for patient survival.
  • This study demonstrates for the first time that expression of a member of the SLY1-gene family has prognostic significance in human cancer.
  • [MeSH-minor] Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. Colon / metabolism. Colon / pathology. Down-Regulation. Female. Genes, Tumor Suppressor. Humans. Liver Neoplasms / genetics. Liver Neoplasms / metabolism. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 17088907.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / SASH1 protein, human; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC2360597
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12. Bitencourt Fda S, Figueiredo JG, Mota MR, Bezerra CC, Silvestre PP, Vale MR, Nascimento KS, Sampaio AH, Nagano CS, Saker-Sampaio S, Farias WR, Cavada BS, Assreuy AM, de Alencar NM: Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis. Naunyn Schmiedebergs Arch Pharmacol; 2008 Apr;377(2):139-48
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  • [Title] Antinociceptive and anti-inflammatory effects of a mucin-binding agglutinin isolated from the red marine alga Hypnea cervicornis.
  • The agglutinin from the red marine alga Hypnea cervicornis (HCA) was tested in models of nociception and inflammation.
  • HCA (10(-1), 1, and 10 mg/kg) administered i.v. to mice inhibited writhes induced by acetic acid and, at 10 mg/kg, inhibited the second phase of the formalin test, but did not alter the response latency in the hot-plate test.
  • HCA (1 mg/kg) administered i.v. to rats reduced carrageenan-induced paw edema at 1, 2, and 3 h after challenge, but not edema induced by dextran.
  • The neutrophil migration induced by both N-formyl-methionyl-leucyl-phenylalanine (fMLP) and carrageenan was inhibited by HCA at 10(-1), 1, and 10 mg/kg.
  • The combination of HCA (1 mg/kg) and its ligand mucin reversed the lectin inhibitory effect on carrageenan-induced neutrophil migration and acetic acid-induced writhes.
  • The i.v. treatment of rats with HCA (1 mg/kg) for 7 days did not affect body mass; liver, kidney or heart wet weight; blood leukocyte counts; urea, creatinine or serum transaminase activity; or macroscopy of the organs examined.

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  • (PMID = 18270688.001).
  • [ISSN] 0028-1298
  • [Journal-full-title] Naunyn-Schmiedeberg's archives of pharmacology
  • [ISO-abbreviation] Naunyn Schmiedebergs Arch. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Agglutinins; 0 / Analgesics; 0 / Anti-Inflammatory Agents; 0 / Lectins; 0 / Mucins
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13. Galloro V: HCA scores on bond market. First-quarter earnings expected to top $600 million. Mod Healthc; 2009 Apr 20;39(16):12-3
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  • [Title] HCA scores on bond market. First-quarter earnings expected to top $600 million.

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  • (PMID = 19422133.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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14. Feuerlein S, Pauls S, Juchems MS, Stuber T, Hoffmann MH, Brambs HJ, Ernst AS: Pitfalls in abdominal diffusion-weighted imaging: how predictive is restricted water diffusion for malignancy. AJR Am J Roentgenol; 2009 Oct;193(4):1070-6
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  • The aim of our retrospective study was to investigate the specificity of restricted diffusion in differentiation of benign from malignant abdominal disease.
  • Lesions were detected by two blinded readers using only the images with a b value of 1,000 s/mm(2), and representative apparent diffusion coefficients were measured.
  • The 12 benign lesions were liver hemangioma, liver adenoma, autoimmune pancreatitis, pancreatic teratoma, two abscesses, three cases of inflammatory bowel wall thickening due to Crohn's disease, Bartholin cyst, hemorrhagic ovarian cyst, and renal Rosai-Dorfman disease.
  • However, in interpretation of diffusion-weighted images, it should be kept in mind that a number of benign lesions, as many as 22% in our cohort, can exhibit restricted diffusion on images with high b values, thus mimicking malignant lesions.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Artifacts. Diffusion Magnetic Resonance Imaging / methods

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  • (PMID = 19770331.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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15. Nishimura-Sakurai Y, Sakamoto N, Mogushi K, Nagaie S, Nakagawa M, Itsui Y, Tasaka-Fujita M, Onuki-Karakama Y, Suda G, Mishima K, Yamamoto M, Ueyama M, Funaoka Y, Watanabe T, Azuma S, Sekine-Osajima Y, Kakinuma S, Tsuchiya K, Enomoto N, Tanaka H, Watanabe M: Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells. J Gastroenterol; 2010 May;45(5):523-36
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  • [Title] Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells.
  • Here, we screened host genes and molecular pathways that are involved in HCV replication by comprehensive analyses using two genotypes of HCV replicon-expressing cells, their cured cells and naïve Huh7 cells.
  • METHODS: Huh7 cell lines that stably expressed HCV genotype 1b or 2a replicon were used.
  • The cured cells were established by treating HCV replicon cells with interferon-alpha.
  • RESULTS: Hierarchical clustering analysis showed that the gene-expression profiles of each cell group constituted clear clusters of naïve, HCV replicon-expressed, and cured cell lines.
  • The pathway process analysis between the replicon-expressing and the cured cell lines identified significantly altered pathways, including MAPK, steroid biosynthesis and TGF-beta signaling pathways, suggesting that these pathways were affected directly by HCV replication.
  • Comparison of cured and naïve Huh7 cells identified pathways, including steroid biosynthesis and sphingolipid metabolism, suggesting that these pathways were required for efficient HCV replication.
  • Cytoplasmic lipid droplets were obviously increased in replicon-expressing and cured cells as compared to naïve cells.
  • CONCLUSION: Comprehensive gene expression and pathway analyses show that lipid biosynthesis pathways are crucial to support proficient virus replication.
  • [MeSH-minor] Cell Culture Techniques. Cell Line. Cluster Analysis. Gene Expression Profiling. Humans. Lipid Metabolism / physiology. Oligonucleotide Array Sequence Analysis

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  • (PMID = 20012654.001).
  • [ISSN] 1435-5922
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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16. Mi J, Apraiz I, Cristobal S: Peroxisomal proteomic approach for protein profiling in blue mussels (Mytilus edulis) exposed to crude oil. Biomarkers; 2007 Jan-Feb;12(1):47-60
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  • In the study, peroxisome-enriched fractions from digestive gland of M. edulis (L., 1758) were analysed by two-dimensional fluorescence difference electrophoresis (DIGE) and mass spectrometry (MS) after 3 weeks of exposure to crude oil mixtures: crude oil or crude oil spiked with alkylated phenols (AP) and extra polycyclic aromatic hydrocarbons (PAH) in a laboratory flow-through system.
  • The hierarchical clustering analysis succeeded in discriminating the exposed groups from the control groups based on the unique PES.
  • [MeSH-major] Bivalvia / chemistry. Peroxisomes / drug effects. Petroleum / toxicity. Proteins / analysis. Proteomics. Water Pollutants, Chemical / toxicity

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  • (PMID = 17438653.001).
  • [ISSN] 1354-750X
  • [Journal-full-title] Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • [ISO-abbreviation] Biomarkers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Petroleum; 0 / Proteins; 0 / Water Pollutants, Chemical
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17. Zhao H, Ljungberg B, Grankvist K, Rasmuson T, Tibshirani R, Brooks JD: Gene expression profiling predicts survival in conventional renal cell carcinoma. PLoS Med; 2006 Jan;3(1):e13
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  • [Title] Gene expression profiling predicts survival in conventional renal cell carcinoma.
  • BACKGROUND: Conventional renal cell carcinoma (cRCC) accounts for most of the deaths due to kidney cancer.
  • Unsupervised hierarchical clustering analysis segregated cRCC into five gene expression subgroups.
  • A semisupervised learning algorithm (supervised principal components analysis) was applied to identify transcripts whose expression was associated with survival in the training set, and the performance of this gene expression-based survival predictor was assessed using the test set.
  • With this method, we identified 259 genes that accurately predicted disease-specific survival among patients in the independent validation group (p < 0.001).
  • In multivariate analysis, the gene expression predictor was a strong predictor of survival independent of tumor stage, grade, and performance status (p < 0.001).
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Kidney Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Algorithms. Cluster Analysis. Female. Humans. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Survival Analysis

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  • (PMID = 16318415.001).
  • [ISSN] 1549-1676
  • [Journal-full-title] PLoS medicine
  • [ISO-abbreviation] PLoS Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1298943
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18. Ma W, Xia X, Stafford LJ, Yu C, Wang F, LeSage G, Liu M: Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. Oncogene; 2006 Jul 13;25(30):4207-16
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  • Transcription factors with helix-loop-helix (HLH) motif play critical roles in controlling the expression of genes involved in lineage commitment, cell fate determination, proliferation, and tumorigenesis.
  • To examine whether the newly identified HLH protein GCIP/CCNDBP1 modulates cell fate determination and plays a role in hepatocyte growth, proliferation, and hepatocarcinogenesis, we generated transgenic mice with human GCIP gene driven by a liver-specific albumin promoter.
  • We demonstrated that in GCIP transgenic mice, the overall liver growth and regeneration occurred normally after liver injury induced by carbon tetrachloride (CCl4).
  • In the diethylnitrosamine (DEN)-induced mouse hepatocarcinogenesis, we demonstrated that overexpression of GCIP in mouse liver suppressed DEN-induced hepatocarcinogenesis at an early stage of tumor development.
  • The number of hepatic adenomas at 24 weeks was significantly lower or not detected in GCIP transgenic male mice compared to the control mice under the same treatment.
  • Although GCIP has little inhibition on the number of hepatic tumors at later stages (40 weeks), hepatocellular tumors in GCIP transgenic mice are smaller and well-differentiated compared to the poorly differentiated tumors in wild-type mice.
  • Furthermore, we demonstrate that GCIP functions as a transcriptional suppressor, regulates the expression of cyclin D1, and inhibits anchorage-independent cell growth and colony formation in HepG2 cells, suggesting a significant role of GCIP in tumor initiation and development.
  • [MeSH-major] Genetic Predisposition to Disease. Liver Neoplasms, Experimental / chemically induced. Liver Neoplasms, Experimental / genetics. Transcription Factors / biosynthesis. Transcription Factors / genetics
  • [MeSH-minor] Animals. Carbon Tetrachloride / toxicity. Carcinogens / toxicity. Cell Line, Tumor. Female. Humans. Male. Mice. Mice, Transgenic

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  • (PMID = 16501603.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R01CA106479; United States / NHLBI NIH HHS / HL / 5R01HL064792
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CCNDBP1 protein, human; 0 / Carcinogens; 0 / Transcription Factors; CL2T97X0V0 / Carbon Tetrachloride
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19. Valls C, Iannacconne R, Alba E, Murakami T, Hori M, Passariello R, Vilgrain V: Fat in the liver: diagnosis and characterization. Eur Radiol; 2006 Oct;16(10):2292-308
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  • [Title] Fat in the liver: diagnosis and characterization.
  • The purpose of this article is to provide an update on imaging techniques useful for detection and characterization of fat in the liver.
  • Imaging findings of liver steatosis, both diffuse steatosis and focal fatty change, as well as focal fatty sparing, are presented.
  • In addition, we will review computed tomography (CT) and magnetic resonance (MR) findings of focal liver lesions with fatty metamorphosis, including hepatocellular carcinoma, hepatocellular adenoma, focal nodular hyperplasia, angiomyolipoma, lipoma, and metastases.
  • [MeSH-major] Diagnostic Imaging. Fatty Liver / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology. Neoplasms, Adipose Tissue / diagnosis. Neoplasms, Adipose Tissue / pathology

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  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 41
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20. Kai K, Miyoshi A, Tokunaga O, Kitahara K, Takahashi T, Miyake S, Egashira Y, Irie H, Noshiro H, Miyazaki K: A hepatocellular neoplasm accompanied with massive histiocyte infiltration. Clin J Gastroenterol; 2010 Feb;3(1):40-4
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  • [Title] A hepatocellular neoplasm accompanied with massive histiocyte infiltration.
  • This report presents the case of a unique hepatocellular nodule occurring in a 73-year-old Japanese male with diabetes mellitus and mild obesity.
  • The nodule consisted of hepatocyte-like tumor cells and abundant foam cell type histiocytes that filled up a sinusoid-like space and formed central loose fibrosis.
  • The superficial area did not contain as many histiocytes and showed hepatocellular adenoma character, but there was a focal hepatocellular carcinoma-like lesion, thus suggesting hepatocellular adenoma with malignant transformation.
  • The background liver showed an almost normal histology except for mild steatosis with no specific infiltration of macrophages.
  • These macrophages contained abundant fat droplets, whereas the tumor cells had no fat droplets.
  • The expressions of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor were significantly higher in the tumor than in the background liver.
  • These findings suggested such macrophage infiltration induced by the tumor cells and these macrophages probably phagocytosed surplus fat at the intercellular space of this unique tumor.

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  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Hepatocellular adenoma / Hepatocellular carcinoma / Histiocyte / Macrophage colony-stimulating factor / Monocyte chemoattractant protein-1
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21. Gilbert KM, Venanzi CA: Hierarchical clustering analysis of flexible GBR 12909 dialkyl piperazine and piperidine analogs. J Comput Aided Mol Des; 2006 Apr;20(4):209-25
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  • [Title] Hierarchical clustering analysis of flexible GBR 12909 dialkyl piperazine and piperidine analogs.
  • A comprehensive hierarchical clustering study of two GBR 12909 analogs was performed to identify representative conformers for input to three-dimensional quantitative structure-activity relationship studies of closely-related analogs.
  • Two data sets of more than 700 conformers each produced by random search conformational analysis of a piperazine and a piperidine GBR 12909 analog were studied.
  • Several clustering studies were carried out based on different feature sets that include the important pharmacophore elements.
  • The distance maps, the plot of the effective number of clusters versus actual number of clusters, and the novel derived clustering statistic, percentage change in the effective number of clusters, were shown to be useful in determining the appropriate clustering level.
  • This study illustrates the utility of using hierarchical clustering for the classification of conformers of highly flexible molecules in terms of the three-dimensional spatial orientation of key pharmacophore elements.
  • [MeSH-minor] Cluster Analysis. Dopamine Uptake Inhibitors / chemistry. Dopamine Uptake Inhibitors / pharmacology. Fuzzy Logic. Models, Molecular. Molecular Conformation. Molecular Structure. Piperidines / chemistry. Piperidines / pharmacology. Quantitative Structure-Activity Relationship. Thermodynamics

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  • (PMID = 16855855.001).
  • [ISSN] 0920-654X
  • [Journal-full-title] Journal of computer-aided molecular design
  • [ISO-abbreviation] J. Comput. Aided Mol. Des.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA015555; United States / NIDA NIH HHS / DA / DA018153
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dopamine Uptake Inhibitors; 0 / Piperazines; 0 / Piperidines; 90X28IKH43 / vanoxerine
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22. Vaahtio M, Peltola T, Hentunen T, Ylänen H, Areva S, Wolke J, Salonen JI: The properties of biomimetically processed calcium phosphate on bioactive ceramics and their response on bone cells. J Mater Sci Mater Med; 2006 Nov;17(11):1113-25
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  • [Title] The properties of biomimetically processed calcium phosphate on bioactive ceramics and their response on bone cells.
  • This study looks for grounds to alter the chemical composition (phosphate, calcium, silica and carbonate), dissolution properties, structure and nanotopography of the biomimetically processed surfaces on bioactive ceramics to optimize their shown ability to influence bone cell behaviour and production of new bone.
  • The CaP so formed in R-SBF with faster precipitation is more amorphous than the bonelike HCA formed in C-SBF.
  • [MeSH-minor] Animals. Animals, Newborn. Cell Line, Tumor. Cells, Cultured. Humans. Rats

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  • (PMID = 17122926.001).
  • [ISSN] 0957-4530
  • [Journal-full-title] Journal of materials science. Materials in medicine
  • [ISO-abbreviation] J Mater Sci Mater Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Phosphates; 85422-94-2 / Glass ceramics; 97Z1WI3NDX / calcium phosphate
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23. Kadam RU, Roy N: Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors. Bioorg Med Chem Lett; 2006 Oct 1;16(19):5136-43
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  • [Title] Cluster analysis and two-dimensional quantitative structure-activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors.
  • We report herein, the development of cluster analysis-based 2D-QSAR models for LpxC inhibition.
  • Principal component analysis (PCA), hierarchical cluster analysis (HCA), and genetic function approximation (GFA) were employed for the development of the QSAR model.
  • Descriptor-based cluster analysis indicated that the three-structural classes of LpxC inhibitors studied belonged to two clusters.
  • [MeSH-minor] Cluster Analysis. Drug Evaluation, Preclinical / methods. Inhibitory Concentration 50

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  • (PMID = 16879960.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / LpxC deacetylase, Pseudomonas
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24. Zhang YB, Lin HF, Lv L, Hua WG, Tian F, Shen GZ, Xia ZL, Jin XP: [In vitro evaluation of cutaneous allergic reaction induced by chemicals using dendritic cells]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi; 2008 Mar;26(3):147-50
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  • [Title] [In vitro evaluation of cutaneous allergic reaction induced by chemicals using dendritic cells].
  • OBJECTIVE: To investigate the use of dendritic cells derived from mice bone marrow to evaluate the cutaneous allergic reaction induced by chemical sensitizers.
  • METHODS: Dendritic cells derived from mice bone marrow were cultured and administrated with 2, 4-dinitrochlorobenzene (DNCB), nickel sulfate (NiSO4), sodium dodecyl sulfate (SDS) and hexyl cinnamic aldehyde (HCA), respectively.
  • Cell membrane molecule CD86 and extracellular IL-1 beta, IL-6 and IL-12 were detected after 0, 1, 6, 12, 24, 36, 48 hour's administration, respectively.
  • RESULTS: CD86 expression reached the highest level after exposure to DNCB for 48 h, and increased by about 279% compared with the control (P < 0.05), while it was lower than that of control after administrated with NiSO4 and HCA for 1 h and 6 h, and SDS for 36 h, respectively (P < 0.05).
  • Extracellular IL-1 beta increased greatly after exposure to NiSO4 just for 1 h, with the maximum at 48 h (298 pg/ml, P < 0.05), and after exposure to HCA for 6 h, with maximum at 48 h (84 pg/ml, P < 0.05).
  • After exposure to HCA, extracellular IL-6 reached the maximum at 1 h (1403 pg/ml), and then it was decreased quickly, but still higher than the control (P < 0.05), while it didn't change significantly after treatment with DNCB and SDS, compared with the control (P > 0.05).
  • CONCLUSION: Chemical sensitizer DNCB could induce the high expression of CD86 on DC membrane, and NiSO4 and HCA could induce DC to release IL-1 beta and IL-6.
  • [MeSH-major] Dendritic Cells / drug effects. Dinitrochlorobenzene / pharmacology. Nickel / pharmacology. Sodium Dodecyl Sulfate / pharmacology
  • [MeSH-minor] Animals. Antigens, CD86 / metabolism. Cells, Cultured. Interleukin-12 / metabolism. Interleukin-1beta / metabolism. Interleukin-6 / metabolism. Mice. Mice, Inbred C57BL

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  • (PMID = 18761792.001).
  • [ISSN] 1001-9391
  • [Journal-full-title] Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
  • [ISO-abbreviation] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD86; 0 / Interleukin-1beta; 0 / Interleukin-6; 187348-17-0 / Interleukin-12; 368GB5141J / Sodium Dodecyl Sulfate; 4FLT4T3WUN / nickel sulfate; 7OV03QG267 / Nickel; GE3IBT7BMN / Dinitrochlorobenzene
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25. Culp SJ, Mellick PW, Trotter RW, Greenlees KJ, Kodell RL, Beland FA: Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats. Food Chem Toxicol; 2006 Aug;44(8):1204-12
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  • Female rats exposed to malachite green chloride had increased incidences of thyroid gland follicular cell adenoma or carcinoma and hepatocellular adenoma, and a dose-related increasing trend in mammary gland carcinoma.
  • Female rats fed malachite green chloride and female and male rats fed leucomalachite green had a dose-related decreasing trend in the incidence of mononuclear cell leukemia.
  • In male rats fed leucomalachite green there was a decreasing trend in pituitary gland adenoma and an increasing trend in interstitial cell adenoma of the testis.
  • Female mice fed leucomalachite green had a dose-related increasing trend in the incidence of hepatocellular adenoma or carcinoma, with the incidence being significant in the highest dose group.
  • [MeSH-minor] Animals. Body Weight / drug effects. Carcinogenicity Tests. Eating / drug effects. Female. Male. Mice. Mice, Inbred C57BL. Rats. Rats, Inbred F344. Statistics, Nonparametric. Survival Analysis

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  • (PMID = 16554117.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Fungicides, Industrial; 0 / Rosaniline Dyes; 12058M7ORO / malachite green; 8U61G37Z20 / leucomalachite green
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26. Heppner CW, Schlatter JR: Data requirements for risk assessment of furan in food. Food Addit Contam; 2007;24 Suppl 1:114-21
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  • Furan is carcinogenic in rats and mice, showing a dose-dependent increase in hepatocellular adenomas and carcinomas.
  • In rats, a dose-dependent increase of mononuclear leukaemia is evident and a very high incidence of cholangiocarcinomas of the liver, even at the lowest dose tested.
  • However, chronic toxicity with secondary cell proliferation may indirectly amplify the tumour response.
  • The European Food Safety Authority's (EFSA) Scientific Panel on Contaminants in the Food Chain (CONTAM) recommended these studies as part of a reliable risk assessment of furan in food.
  • [MeSH-major] Carcinogens, Environmental / analysis. Food Contamination / analysis. Furans / analysis
  • [MeSH-minor] Animals. DNA / drug effects. DNA / genetics. Food Analysis / methods. Gas Chromatography-Mass Spectrometry / methods. Humans. Mice. Mutagenesis / drug effects. Neoplasms, Experimental / chemically induced. Proto-Oncogenes / drug effects. Proto-Oncogenes / genetics. Rats. Risk Assessment / methods

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  • (PMID = 17687705.001).
  • [ISSN] 0265-203X
  • [Journal-full-title] Food additives and contaminants
  • [ISO-abbreviation] Food Addit Contam
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens, Environmental; 0 / Furans; 9007-49-2 / DNA; UC0XV6A8N9 / furan
  • [Number-of-references] 34
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27. Haldenwang PL, Strauch JT, Amann I, Klein T, Sterner-Kock A, Christ H, Wahlers T: Impact of pump flow rate during selective cerebral perfusion on cerebral hemodynamics and metabolism. Ann Thorac Surg; 2010 Dec;90(6):1975-84
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  • BACKGROUND: Although hypothermic selective cerebral perfusion (SCP) is widely used for cerebral protection during aortic surgery, little is known about the ideal pump-flow management during this procedure.
  • After 10 minutes of hypothermic circulatory arrest, the animals were randomly assigned to 60 minutes of SCP at two different pump flow rates: 8 mL·kg(-1)·min(-1) (n = 7) and 18 mL·kg(-1)·min(-1) (n = 7).
  • [MeSH-minor] Animals. Aorta, Thoracic / surgery. Disease Models, Animal. Female. Intracranial Pressure / physiology. Oxygen Consumption. Regional Blood Flow / physiology. Stroke / prevention & control. Swine. Vascular Surgical Procedures / methods

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  • [Copyright] Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2010 Dec;90(6):1984 [21095349.001]
  • (PMID = 21095348.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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28. Kiralj R, Ferreira MM: Chemometric analysis of the multidrug resistance in strains of Penicillium digitatum. SAR QSAR Environ Res; 2008 Jan-Mar;19(1-2):55-70
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  • [Title] Chemometric analysis of the multidrug resistance in strains of Penicillium digitatum.
  • Multidrug resistance activities pECr50 of diverse strains of pathogenic fungus Penicillium digitatum against seven toxicants were studied by Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA).
  • This data set was studied by PCA and HCA, and was correlated with the genome descriptor PCR for expression of gene CYP51 by Partial Least Squares (PLS) regression.
  • Both analyses of pECr50 data and of fungal growth data have identified baseline resistance character, origin and target fruits of the fungal strains.
  • In addition, the analysis of fungal growth data shows that fungal growth morphology is multivariate by nature, meaning that experimental data can be explored more intensely than in usual practice.
  • [MeSH-minor] Cluster Analysis. Cytochrome P-450 Enzyme System / genetics. Fungal Proteins / genetics. Principal Component Analysis

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  • (PMID = 18311634.001).
  • [ISSN] 1062-936X
  • [Journal-full-title] SAR and QSAR in environmental research
  • [ISO-abbreviation] SAR QSAR Environ Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Fungal Proteins; 0 / Fungicides, Industrial; 9035-51-2 / Cytochrome P-450 Enzyme System
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29. Satoh J: [Molecular biomarkers for prediction of multiple sclerosis relapse]. Nihon Rinsho; 2008 Jun;66(6):1103-11
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  • Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system white matter mediated by an autoimmune process, whose development is triggered by a complex interplay of multiple genetic, infectious and environmental factors.
  • DNA microarray is a novel technology that allows us to systematically monitor the expression of whole human genome in disease-affected tissues and cells.
  • By using DNA microarray, we have recently studied gene expression profile of peripheral blood T cells isolated from clinically active MS patients and healthy controls, and from MS patients in relapse and during remission.
  • Hierarchical clustering analysis of the discriminator genes established classification of MS subgroups that exhibit distinct gene expression profiles and relapse-specific molecular signatures.
  • [MeSH-major] Biomarkers / analysis. Multiple Sclerosis / diagnosis. Multiple Sclerosis / genetics
  • [MeSH-minor] Humans. Protein Array Analysis. Recurrence

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  • (PMID = 18540355.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers
  • [Number-of-references] 40
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31. Yamamoto T, Kikkawa R, Yamada H, Horii I: Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants. J Toxicol Sci; 2006 Feb;31(1):49-60
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  • [Title] Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants.
  • Acetaminophen (APAP), amiodarone (AMD), tetracycline (TC) and carbon tetrachloride (CTC) were administered to male rats by gavages and the liver at 24 hr post-dosing was applied to the proteomic experiment.
  • Protein expression in the liver was investigated by 2-dimensional gel electrophoresis (2DE), and spots showing a significantly different expression in treated versus control group were excised from gels and identified by Q-Tof mass spectrometer.
  • Moreover, hierarchical clustering analysis using 2D-gel spots information revealed the possibility to differentiate the groups based on their toxicity levels such as severity of liver damage.
  • [MeSH-major] Acetaminophen / toxicity. Amiodarone / toxicity. Carbon Tetrachloride / toxicity. Liver / drug effects. Proteins / metabolism. Tetracycline / toxicity


32. Ferrara DE, Weiss D, Carnell PH, Vito RP, Vega D, Gao X, Nie S, Taylor WR: Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon excitation laser scanning microscopy. Am J Physiol Regul Integr Comp Physiol; 2006 Jan;290(1):R114-23
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  • [Title] Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon excitation laser scanning microscopy.
  • We studied human coronary arteries (HCAs) and mouse aortas with a modified immunohistochemical (IHC) "en face" method using quantum dot (Qdot) bioconjugates and two-photon excitation laser scanning microscopy (TPELSM).
  • Detailed cell structures, such as the granular appearance of von Willebrand factor (VWF) and the subcellular distribution of endothelial nitric oxide synthase, were visualized using green dots (525 nm), even when the emission maximum of these Qdots overlapped that of tissue autofluorescence (510-520 nm).
  • In addition, sensitive fluorescence quantification of vascular cell adhesion molecule 1 expression at areas of varying hemodynamics (intercostal branches vs. nonbranching areas) was performed in normal C57Bl/6 mice.

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  • (PMID = 16223849.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / P20 GM072069; United States / NCI NIH HHS / CA / R01 CA108468; United States / PHS HHS / / R-01-L70531; United States / NIH HHS / NH / U0-1-NH-080711
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Vascular Cell Adhesion Molecule-1
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33. Gutiérrez NC, López-Pérez R, Hernández JM, Isidro I, González B, Delgado M, Fermiñán E, García JL, Vázquez L, González M, San Miguel JF: Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia. Leukemia; 2005 Mar;19(3):402-9
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  • Bone marrow samples from 43 adult patients with de novo diagnosed acute myeloid leukemia (AML)--10 acute promyelocytic leukemias (APL) with t(15;17), four AML with inv(16), seven monocytic leukemias and 22 nonmonocytic leukemias--were analyzed using high-density oligonucleotide microarrays.
  • Hierarchical clustering analysis segregated APL, AML with inv(16), monocytic leukemias and the remaining AML into separate groups.
  • Quantitative RT-PCR performed for 18 out of these predictor genes confirmed microarray results.
  • AML with inv(16) showed an upregulation of MYH11 and a downregulation of a gene encoding a core-binding factor protein, RUNX3.
  • Genes involved in cell adhesion represented the most altered functional category in monocytic leukemias.
  • In the latter cluster, CD34 upregulation and serine proteases downregulation is consistent with a maturation arrest and lack of granulocytic differentiation.
  • [MeSH-minor] Adolescent. Adult. Aged. Cluster Analysis. Female. Humans. Leukemia, Monocytic, Acute / genetics. Leukemia, Promyelocytic, Acute / genetics. Male. Middle Aged. Phylogeny. Retrospective Studies


34. Pavón JL, Peña AG, Pinto CG, Cordero BM: Differentiation of types of crude oils in polluted soil samples by headspace-fast gas chromatography-mass spectrometry. J Chromatogr A; 2006 Dec 22;1137(1):101-9
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  • The coupling of a headspace sampler to a fast gas chromatography system with mass spectrometry detection is proposed as a method for the identification of the sources of contamination in soils due to the presence of hydrocarbons derived from petroleum.
  • Chemometric treatments, such as hierarchical cluster analysis (HCA), principal component analysis (PCA), and soft independent modelling of class analogy (SIMCA) were applied to the signals obtained for the different samples.
  • [MeSH-major] Gas Chromatography-Mass Spectrometry / methods. Petroleum / analysis. Soil Pollutants / analysis
  • [MeSH-minor] Pilot Projects. Principal Component Analysis

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  • (PMID = 17056051.001).
  • [ISSN] 0021-9673
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Petroleum; 0 / Soil Pollutants
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35. Gasparri F, Cappella P, Galvani A: Multiparametric cell cycle analysis by automated microscopy. J Biomol Screen; 2006 Sep;11(6):586-98
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  • [Title] Multiparametric cell cycle analysis by automated microscopy.
  • Cell cycle analysis using flow cytometry (FC) to measure cellular DNA content is a common procedure in drug mechanism of action studies.
  • Although this technique lends itself readily to cell lines that grow in suspension, adherent cell cultures must be resuspended in a cumbersome and potentially invasive procedure that normally involves trypsinization and mechanical agitation of monolayer cultures.
  • High-content analysis (HCA), an automated microscopy-based technology, is well suited to analysis of monolayer cell cultures but provides intrinsically less accurate determination of cellular DNA content than does FC and thus is not the method of choice for cell cycle analysis.
  • Using Cellomics's ArrayScan reader, the authors have developed a 4-color multiparametric HCA approach for cell cycle analysis of adherent cells based on detection of DNA content (4,6-diamidino-2-phenylindole [DAPI] fluorescence), together with the known cell cycle markers bromo-2-deoxyuridine (BrdU) incorporation, cyclin B1 expression, and histone H3 (Ser28) phosphorylation within a single cell population.
  • Considering all 4 markers together, a reliable and accurate quantification of cell cycle phases was possible, as compared with flow cytometric analysis.
  • Using this assay, specific cell cycle blocks induced by treatment with thymidine, paclitaxel, or nocodazole as test drugs were easily monitored in adherent cultures of U-2 OS osteosarcoma cells.
  • [MeSH-major] Cell Cycle / physiology. Flow Cytometry / instrumentation. Microscopy / instrumentation
  • [MeSH-minor] Automation. Bromodeoxyuridine / pharmacology. Cell Division / drug effects. Cells, Cultured. DNA / analysis. Humans

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  • (PMID = 16844964.001).
  • [ISSN] 1087-0571
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA; G34N38R2N1 / Bromodeoxyuridine
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36. Pousios D, Velissaris T, Duggan S, Tsang G: Floating intra-aortic thrombus presenting as distal arterial embolism. Interact Cardiovasc Thorac Surg; 2009 Sep;9(3):532-4
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  • Floating thrombi in the aorta are a rare finding in the absence of any coagulation abnormality.
  • There was no pre-existing clotting abnormality.
  • Under temporary hypothermic circulatory arrest, the ascending aorta was opened.
  • The lesion was removed along with a rim of aortic wall, circulation was re-established and the aorta was reconnected with use of a synthetic interposition graft.
  • Only a few cases of intra-aortic thrombus without any coagulation abnormality basis are described in literature.
  • [MeSH-minor] Acute Disease. Administration, Oral. Anticoagulants / administration & dosage. Aortography / methods. Blood Vessel Prosthesis Implantation. Cardiopulmonary Bypass. Circulatory Arrest, Deep Hypothermia Induced. Female. Humans. Ischemic Attack, Transient / etiology. Magnetic Resonance Angiography. Middle Aged. Sternum / surgery. Tomography, X-Ray Computed. Treatment Failure

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  • (PMID = 19454418.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticoagulants
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37. Elder I, Fisher Z, Laipis PJ, Tu C, McKenna R, Silverman DN: Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III. Proteins; 2007 Jul 1;68(1):337-43
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  • [Title] Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.
  • We report the X-ray crystal structures and rate constants for proton transfer in site-specific mutants of human carbonic anhydrase III (HCA III) that place a histidine residue in the active-site cavity: K64H, R67H, and K64H-R67N HCA III.
  • Prior evidence from the exchange of 18O between CO2 and water measured by mass spectrometry shows each mutant to have enhanced proton transfer in catalysis compared with wild-type HCA III.
  • However, His64 in K64H and K64H-R67N HCA III have at most a capacity for proton transfer that is only 13% that of His64 in HCA II.
  • This reduced rate in mutants of HCA III is associated with a constrained side-chain conformation of His64, which is oriented outward, away from the active-site zinc in the crystal structures.
  • This conformation appears stabilized by a prominent pi stacking interaction of the imidazole ring of His64 with the indole ring of Trp5 in mutants of HCA III.
  • This single orientation of His64 in K64H HCA III predominates also in a double mutant K64H-R67N HCA III, indicating that the positive charge of Arg67 does not influence the observed conformation of His64 in the crystal structure.
  • Hence, the structures and catalytic activity of these mutants of HCA III containing His64 account only in small part for the lower activity of this isozyme compared with HCA II.
  • His67 in R67H HCA III was also shown to be a proton shuttle residue, having a capacity for proton transfer that was approximately four times that of His64 in K64H HCA III.

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  • [Copyright] 2007 Wiley-Liss, Inc.
  • (PMID = 17427958.001).
  • [ISSN] 1097-0134
  • [Journal-full-title] Proteins
  • [ISO-abbreviation] Proteins
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM 25154
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protons; EC 4.2.1.- / Carbonic Anhydrase III
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38. Chen ZM, Crone KG, Watson MA, Pfeifer JD, Wang HL: Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma. Am J Surg Pathol; 2005 Dec;29(12):1600-8
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  • [Title] Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma.
  • It is often difficult to distinguish hepatocellular adenoma (HCA) from well-differentiated hepatocellular carcinoma (WDHCC) when limited tissue from a needle biopsy is evaluated.
  • The aim of this study was to identify gene expression patterns that can distinguish HCA from WDHCC, with the ultimate goal of discovering novel diagnostic markers.
  • Gene expression profile analysis was performed using Affymetrix U133Plus2 GeneChip microarrays on RNA isolated from frozen tissue of 6 HCA and 8 WDHCC specimens.
  • Statistical analysis of microarray data identified 63 genes whose expression levels were significantly different between HCA and WDHCC.
  • These included 57 genes overexpressed by HCA and 6 overexpressed by WDHCC.
  • Eight genes were chosen for further analysis by quantitative RT-PCR on RNA derived from archived, paraffin-embedded tissue blocks of an independent validation set comprising 9 HCAs and 9 HCCs.
  • Seven of the 8 genes demonstrated average expression differences between HCA and HCC that were concordant with the microarray findings, and their expression pattern correctly classified the 18 tumors into HCA and HCC using unsupervised clustering analysis.
  • Furthermore, immunohistochemical staining performed on a third, independent set of 27 HCAs and 33 HCCs confirmed the expression differences at protein levels for 5 of the genes.
  • Taken together, our data demonstrate significant molecular differences between HCA and WDHCC, despite their morphologic similarity.
  • More importantly, we have identified a unique set of genes whose expression pattern can discriminate between these two types of hepatocellular neoplasms, suggesting the possibility of future development of ancillary molecular and immunohistochemical diagnostic methods.
  • [MeSH-major] Adenoma, Liver Cell / genetics. Adenoma, Liver Cell / metabolism. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / metabolism. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Cluster Analysis. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Male. Middle Aged. Nucleic Acid Hybridization. Oligonucleotide Array Sequence Analysis. RNA / metabolism. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16327432.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 63231-63-0 / RNA
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39. Mantone J: HCA hits gain-sharing hurdle. Vendor objects to comments on usage levels. Mod Healthc; 2006 Feb 13;36(7):12
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  • [Title] HCA hits gain-sharing hurdle. Vendor objects to comments on usage levels.

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  • (PMID = 16515059.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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40. Gitto R, Agnello S, Ferro S, Vullo D, Supuran CT, Chimirri A: Identification of potent and selective human carbonic anhydrase VII (hCA VII) inhibitors. ChemMedChem; 2010 Jun 7;5(6):823-6
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  • [Title] Identification of potent and selective human carbonic anhydrase VII (hCA VII) inhibitors.

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  • (PMID = 20349499.001).
  • [ISSN] 1860-7187
  • [Journal-full-title] ChemMedChem
  • [ISO-abbreviation] ChemMedChem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Protein Isoforms; 0 / Sulfonamides; EC 4.2.1.1 / Carbonic Anhydrases; EC 4.2.1.1 / carbonic anhydrase VI
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41. Di Leo A, Barone M, Maiorano E, Tanzi S, Piscitelli D, Marangi S, Lofano K, Ierardi E, Principi M, Francavilla A: ER-beta expression in large bowel adenomas: implications in colon carcinogenesis. Dig Liver Dis; 2008 Apr;40(4):260-6
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  • [Title] ER-beta expression in large bowel adenomas: implications in colon carcinogenesis.
  • AIM: In the present study, we evaluated oestrogen receptor-beta expression and its possible correlation with proliferative activity and apoptosis in colorectal adenomas and normal colon tissue.
  • Cell proliferative activity significantly increased in adenomatous tissue compared to normal mucosa (59.3+/-7.1 vs. 18.5+/-8.8; p<0.0001), doubling the PCNA/apoptosis ratio.
  • An inverse correlation was found between oestrogen receptor-beta and PCNA expression in adenomas (r=-0.81), a datum confirmed by confocal microscopy evaluation.
  • [MeSH-major] Adenoma / metabolism. Estrogen Receptor beta / metabolism. Intestinal Neoplasms / metabolism

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  • (PMID = 18093886.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Estrogen Receptor beta
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42. Shuhaiber JH: Evaluating the quality of trials of hypothermic circulatory arrest aortic surgery. Asian Cardiovasc Thorac Ann; 2007 Oct;15(5):449-52
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  • [Title] Evaluating the quality of trials of hypothermic circulatory arrest aortic surgery.
  • The quality of level 1 evidence in reports on deep hypothermic circulatory arrest was assessed, and the confounding factors in surgical management and study design that can prevent meta-analysis formulation were determined.
  • A systematic search of the literature was conducted using categorized nomenclature for randomized controlled trials in adult patients undergoing deep hypothermic circulatory arrest in the last 40 years.
  • Twelve randomized controlled trials (2.3%) were found among 504 publications on deep hypothermic circulatory arrest listed on Medline from 1960; only 4 of them related to adults.
  • One adequately powered study demonstrated reduced blood loss in deep hypothermic circulatory arrest using aprotinin.
  • Existing studies of deep hypothermic circulatory arrest are insufficient and inconsistent in the outcome measured, which explains the lack of a meta-analysis.
  • [MeSH-major] Aortic Diseases / surgery. Cerebrovascular Disorders / etiology. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Meta-Analysis as Topic. Randomized Controlled Trials as Topic / standards. Vascular Surgical Procedures

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  • (PMID = 17911080.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 17
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43. Jeannot E, Poussin K, Chiche L, Bacq Y, Sturm N, Scoazec JY, Buffet C, Van Nhieu JT, Bellanné-Chantelot C, de Toma C, Laurent-Puig P, Bioulac-Sage P, Zucman-Rossi J: Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. Cancer Res; 2007 Mar 15;67(6):2611-6
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  • [Title] Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma.
  • Biallelic somatic mutations of TCF1 coding for hepatocyte nuclear factor 1alpha (HNF1alpha) are found in 50% of the hepatocellular adenoma (HCA) cases usually associated with oral contraception.
  • In order to identify new genetic factors predisposing to HNF1alpha-mutated HCA, we searched for mutations in genes involved in the metabolism of estrogen.
  • For 10 genes (CYP1A1, CYP1A2, CYP3A4, CYP3A5, COMT, UGT2B7, NQO1, GSTM1, GSTP1, and GSTT1), we did not find mutations nor differences in the allele distribution among 32 women presenting HNF1alpha-mutated adenomas compared with 58 controls.
  • In contrast, we identified a CYP1B1 germ line heterozygous mutation in 4 of 32 women presenting HNF1alpha-mutated adenomas compared with none in 58 controls.
  • We did an ethoxyresorufin O-deethylase assay to evaluate the functional consequence of the CYP1B1 mutations.
  • In conclusion, our data suggested that CYP1B1 germ line-inactivating mutations might increase the incidence of HCA in women with HNF1alpha mutations.
  • [MeSH-major] Adenoma, Liver Cell / genetics. Cytochrome P-450 Enzyme System / genetics. Germ-Line Mutation. Hepatocyte Nuclear Factor 1-alpha / genetics. Liver Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Alleles. Aryl Hydrocarbon Hydroxylases. Child. Cytochrome P-450 CYP1B1. Female. Genetic Predisposition to Disease. Genotype. Humans. Middle Aged. Mutagenesis, Site-Directed. Pedigree

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  • (PMID = 17363580.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hepatocyte Nuclear Factor 1-alpha; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / CYP1B1 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP1B1
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44. Papanikolaou V, Giakoustidis D, Patsiaura K, Imvrios G, Antoniadis N, Ouzounidis N, Nikopolitidis V, Antoniadis A, Takoudas D: Management of a giant ruptured hepatocellular adenoma. Report of a case. Hippokratia; 2007 Apr;11(2):86-8
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  • [Title] Management of a giant ruptured hepatocellular adenoma. Report of a case.
  • This report describes a rare case of a young woman with massive intra-abdominal bleeding due to a giant ruptured hepatocellular adenoma.
  • The patient had never used oral contraceptive pills and she was urgently operated for haemorrhage control in another hospital where the left hepatic artery was also ligated.
  • After haemodynamic stabilization in the ICU and because of a complicated postoperative course (signs of intraabdominal sepsis) she was transferred to our hospital and a left lobectomy was performed.
  • We present the case and comment on the preferred treatment modalities of hepatocellular adenomas.

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  • (PMID = 19582184.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2464268
  • [Keywords] NOTNLM ; adenoma / giant / hepatocellular / rupture / surgical
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45. Del Rocío Estrada-Sánchez G, Altamirano-Ley J, Ochoa-Carrillo FJ: [Normal variants and frequent pitfalls with (18)FDG PET/CT study]. Cir Cir; 2007 Nov-Dec;75(6):491-7
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  • It enters the cell because of the glucose transporter proteins (GLUTs):.
  • 6) spleen, leucocytes, brain;. 7) liver;.
  • 9) liver, kidney;.
  • 10) liver, pancreas;.
  • 11) heart, muscle;.
  • 12) heart, prostate;. 13) brain.
  • Physiological uptake of (18)FDG was in brain, Waldeyer ring (adenoids, palatine tonsils, lingual tonsils), salivary glands (parotids, submandibular), tongue, vocal cords, cricoarythenoid muscle, thyroid, brown fat (supraclavicular, mediastinal, neck, pericardial fat, around kidney, around great vessels in the thorax, subdiaphragmatic, intercostals, paravertebral), myocardium, breast, thymus, contractive muscles, liver, spleen (similar to the liver), stomach, intestine, kidneys, bladder, uterus, ovaries, testes, bone marrow, esophagus, and atherosclerotic inflammatory plaque.
  • DISCUSSION: False positives were as follows: pneumoniae, tuberculosis, sarcoidosis, cryptococcosis, thrombosis, bronchitis, costochondritis, radiation pneumonitis, misregistration for respiratory movements, catheters, thyroid and adrenal adenomas, osteophytes, fractures, abscess, foreign body, surgical wounds, ostomies, prosthesis, degenerative joint diseases, osteomyelitis, amyloidosis, pancreatitis, myositis, gastritis, colitis, herpes zoster. (18)FDG should be injected 4-6 h after insulin administration because it will be concentrated in the muscles.

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  • (PMID = 18177573.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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46. Peltz M, Sandoval BA, Jessen ME: Traumatic rupture of a descending thoracic aortic homograft. Ann Thorac Surg; 2005 Aug;80(2):710-2
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  • [Title] Traumatic rupture of a descending thoracic aortic homograft.
  • My colleagues and I report an unusual case of traumatic aortic injury in an 18-year-old woman who had undergone multiple prior surgical procedures for repair of a type B interrupted aortic arch.
  • Imaging studies revealed rupture of the body of the aortic homograft with formation of a pseudoaneurysm.
  • The injury was successfully repaired with a Dacron graft by using hypothermic circulatory arrest.
  • [MeSH-minor] Accidents, Traffic. Adolescent. Aneurysm, False / diagnosis. Aneurysm, False / surgery. Blood Vessel Prosthesis Implantation. Female. Humans. Transplantation, Homologous

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  • (PMID = 16039236.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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47. Gargano JW, Holzman C, Senagore P, Thorsen P, Skogstrand K, Hougaard DM, Rahbar MH, Chung H: Mid-pregnancy circulating cytokine levels, histologic chorioamnionitis and spontaneous preterm birth. J Reprod Immunol; 2008 Oct;79(1):100-10
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  • Some spontaneous preterm deliveries (PTD) are caused by occult infections of the fetal membranes (histologic chorioamnionitis [HCA]).
  • High levels of infection-related markers, including some cytokines, sampled from maternal circulation in mid-pregnancy have been linked to PTD, but whether these specifically identify HCA has not been established.
  • We have tested associations between 13 Th1, Th2 and Th17 cytokines and PTD with and without HCA in a prospective cohort study.
  • A panel of cytokines was assessed using a multiplex assay in maternal plasma collected at 15-27 weeks of gestation.
  • Severe HCA was scored by a placental pathologist blinded to clinical variables.
  • Multivariable polytomous logistic regression was used to estimate adjusted odds ratios (OR) per 1 standard deviation (S.D.) increase in cytokine levels using a 5 level outcome variable: PTD <35 weeks with HCA, PTD <35 weeks without HCA, PTD 35-36 weeks with HCA, PTD 35-36 weeks without HCA, and term (referent).
  • Interleukin (IL)-1beta, IL-2, IL-12, interferon-gamma, IL-4, IL-6 and transforming growth factor-beta were all significantly associated with PTD <35 weeks with HCA, with ORs of 1.6-2.3 per S.D. increase.
  • None of these were associated with PTD <35 weeks without HCA or PTD 35-36 weeks with HCA.
  • Although the tissues of origin of circulating cytokines are unclear, the observed elevations across many cytokines among women who later delivered <35 weeks with HCA may represent a robust immune response to infection within gestational tissues.
  • These results suggest that women with HCA could be identified using relatively non-invasive means.

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  • (PMID = 18814919.001).
  • [ISSN] 0165-0378
  • [Journal-full-title] Journal of reproductive immunology
  • [ISO-abbreviation] J. Reprod. Immunol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD34543; United States / NICHD NIH HHS / HD / HD034543-05A1; United States / NICHD NIH HHS / HD / HD034543-07S1; United States / NICHD NIH HHS / HD / HD034543-08; United States / NCCDPHP CDC HHS / DP / U01 DP000143-01; United States / NICHD NIH HHS / HD / R01 HD034543-07; United States / NICHD NIH HHS / HD / R01 HD034543; United States / NICHD NIH HHS / HD / R01 HD034543-04; United States / NICHD NIH HHS / HD / R01 HD034543-06; United States / NICHD NIH HHS / HD / R01 HD034543-03; United States / NICHD NIH HHS / HD / R01 HD034543-05A1; United States / NICHD NIH HHS / HD / HD034543-06; United States / NCCDPHP CDC HHS / DP / U01 DP000143; United States / NICHD NIH HHS / HD / HD034543-03; United States / NICHD NIH HHS / HD / R01 HD034543-08; United States / NICHD NIH HHS / HD / R01 HD034543-07S1; United States / NICHD NIH HHS / HD / HD034543-04; United States / NICHD NIH HHS / HD / HD034543-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Cytokines
  • [Other-IDs] NLM/ NIHMS77538; NLM/ PMC2683663
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48. Urbanski PP, Lenos A, Lindemann Y, Zacher M, Frank S, Diegeler A: Use of a carotid artery for arterial cannulation: side-related differences. Thorac Cardiovasc Surg; 2010 Aug;58(5):276-9
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  • [Title] Use of a carotid artery for arterial cannulation: side-related differences.
  • The arterial line was also used for unilateral cerebral perfusion for brain protection during mild hypothermic circulatory arrest.
  • RESULTS: No complications related to the cannulation of a carotid artery were observed.

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  • [Copyright] Copyright (c) Georg Thieme Verlag KG Stuttgart-New York.
  • [CommentIn] Thorac Cardiovasc Surg. 2010 Dec;58(8):503; author reply 504 [21110280.001]
  • (PMID = 20680903.001).
  • [ISSN] 1439-1902
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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49. Saczewski F, Innocenti A, Brzozowski Z, Slawiński J, Pomarnacka E, Kornicka A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Selective inhibition of human tumor-associated isozymes IX and XII and cytosolic isozymes I and II with some substituted-2-mercapto-benzenesulfonamides. J Enzyme Inhib Med Chem; 2006 Oct;21(5):563-8
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  • These derivatives were medium potency hCA I inhibitors (K(I)s in the range of 1.5-5.7 microM), two derivatives were strong hCA II inhibitors (K(I)s in the range of 15-16 nM), whereas the others showed weak activity.
  • These compounds inhibited hCA IX with inhibition constants in the range 160-1950 nM and hCA XII with inhibition constants in the range 1.2-413 nM.

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  • (PMID = 17194028.001).
  • [ISSN] 1475-6366
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides
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50. Ferrucci LM, Cross AJ, Graubard BI, Brinton LA, McCarty CA, Ziegler RG, Ma X, Mayne ST, Sinha R: Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Br J Cancer; 2009 Jul 7;101(1):178-84
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  • RESULTS: Comparing the fifth to the first quintile, red meat (HR=1.23; 95% CI=1.00-1.51, P trend=0.22), the heterocyclic amine (HCA), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), (HR=1.26; 95% CI=1.03-1.55; P trend=0.12), and dietary iron (HR=1.25; 95% CI=1.02-1.52; P trend=0.03) were positively associated with breast cancer.
  • We observed elevated, though not statistically significant, risks with processed meat, the HCA 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), mutagenic activity, iron from meat, and haem iron from meat.

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  • (PMID = 19513076.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA105666-01; United States / NCI NIH HHS / CA / TU2 CA105666; United States / Intramural NIH HHS / / Z01 CP010127-12; United States / NCI NIH HHS / CA / TU2 CA105666-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iron, Dietary; 0 / Mutagens
  • [Other-IDs] NLM/ PMC2713710
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51. Popescu I, Vasile S, Sgarbură O: [The Pringle maneuver in laparoscopic hepatic surgery: is it useful? Analysis of a series of 38 cases]. Chirurgia (Bucur); 2007 Sep-Oct;102(5):521-5
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  • [Title] [The Pringle maneuver in laparoscopic hepatic surgery: is it useful? Analysis of a series of 38 cases].
  • [Transliterated title] Este utilă manevra Pringle în chirurgia hepatică prin abord laparoscopic? Analiza unei serii de 38 cazuri.
  • The Pringle maneuver is the most feasible method to control bleeding in hepatic resections in both open and laparoscopic approach.
  • This is a retrospective cohort study that includes all hepatic laparoscopic resections performed in our department between 1998-2007 and excludes all exploratory laparoscopies and all cases in which conversion to open procedure was imposed after the lesion assessment and in the absence on any intraoperative event.
  • 38 hepatic laparoscopic resections were performed for both benign lesions (20 out of which 13 hemangiomas, 2 focal nodular hyperplasia, 1 liver cell adenoma, 2 hydatic cysts, 2 inflammatory lesions) and malignant lesions (18 out of which 8 metastases, 9 hepatocellular carcinoma, 1 cholangiocarcinoma).
  • There were 2 conversions to open procedures due to bleeding from hepatic veins collaterals.
  • Pringle maneuver did not prove to be useful in our series because, on one hand, we performed only limited laparoscopic hepatic resections and, on the other hand, intraoperative bleeding was mainly due to lesions of the hepatic veins collaterals which cannot be influenced by clamping the hepatic pedicle.
  • Even if there is no consensus, major laparoscopic hepatic resections may benefit from Pringle maneuver.
  • [MeSH-major] Hepatectomy / methods. Laparoscopy. Liver Diseases / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Liver Neoplasms / surgery. Male. Middle Aged. Treatment Outcome

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  • (PMID = 18018350.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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52. National Toxicology Program: Toxicology and carcinogenesis study of glycidol (CAS No. 556-52-5) in genetically modified haploinsufficient p16(Ink4a)/p19(Arf) mice (gavage study). Natl Toxicol Program Genet Modif Model Rep; 2007 Nov;(13):1-81
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  • Enlarged spleen and foci of discolored liver were observed in 200 mg/kg male mice at necropsy.
  • In the lung, incidences of alveolar/bronchiolar adenoma were significantly increased in 100 mg/kg males and 200 mg/kg females; multiple adenomas were seen in some dosed males.
  • Squamous cell papillomas of the forestomach were seen in one 200 mg/kg male, one 100 mg/kg female, and three 200 mg/kg females.
  • The increased incidences of alveolar/bronchiolar adenomas in male mice were also considered to be related to glycidol administration.
  • There was some evidence of carcinogenic activity of glycidol in haploinsufficient p16(Ink4a)/p19(Arf) female mice based on the occurrence of alveolar/bronchiolar adenoma.
  • [MeSH-major] Adenoma / chemically induced. Carcinogens / toxicity. Epoxy Compounds / toxicity. Histiocytic Sarcoma / chemically induced. Lung Neoplasms / chemically induced. Papilloma / chemically induced. Propanols / toxicity. Stomach Neoplasms / chemically induced

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  • (PMID = 18784757.001).
  • [ISSN] 1556-5246
  • [Journal-full-title] National Toxicology Program genetically modified model report
  • [ISO-abbreviation] Natl Toxicol Program Genet Modif Model Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Epoxy Compounds; 0 / Propanols; S54CF1DV9A / glycidol
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53. Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S: Proteomic signatures for histological types of lung cancer. Proteomics; 2005 Jul;5(11):2939-48
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  • We performed proteomic studies on lung cancer cells to elucidate the mechanisms that determine histological phenotype.
  • Thirty lung cancer cell lines with three different histological backgrounds (squamous cell carcinoma, small cell lung carcinoma and adenocarcinoma) were subjected to two-dimensional difference gel electrophoresis (2-D DIGE) and grouped by multivariate analyses on the basis of their protein expression profiles.
  • We found that hierarchical clustering analysis and principal component analysis divided the cell lines according to their original histology.
  • Spot ranking analysis using a support vector machine algorithm and unsupervised classification methods identified 32 protein spots essential for the classification.
  • Next, lung cancer cells isolated from tumor tissue by laser microdissection were classified on the basis of the expression pattern of these 32 protein spots.
  • Based on the expression profile of the 32 spots, the isolated cancer cells were categorized into three histological groups: the squamous cell carcinoma group, the adenocarcinoma group, and a group of carcinomas with other histological types.
  • In conclusion, our results demonstrate the utility of quantitative proteomic analysis for molecular diagnosis and classification of lung cancer cells.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lung / chemistry. Lung Neoplasms / pathology. Neoplasm Proteins / analysis
  • [MeSH-minor] Adenocarcinoma / pathology. Biomarkers, Tumor. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Small Cell / pathology. Cell Line, Tumor. Electrophoresis, Polyacrylamide Gel. Humans. Microdissection. Multivariate Analysis. Peptide Mapping

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  • (PMID = 15996008.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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54. Lee IJ, Kim SH, Kim DS, Lee JM, Han JK, Choi BI: Intrahepatic extramedullary hematopoiesis mimicking a hypervascular hepatic neoplasm on dynamic- and SPIO-enhanced MRI. Korean J Radiol; 2008 Jul;9 Suppl:S34-8
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  • [Title] Intrahepatic extramedullary hematopoiesis mimicking a hypervascular hepatic neoplasm on dynamic- and SPIO-enhanced MRI.
  • We present a rare case of a focal intrahepatic extramedullary hematopoiesis (EMH) that mimicked a hypervascular hepatic neoplasm in a 33-year-old woman with idiopathic myelofibrosis.
  • The lesion did not demonstrate an apparent signal drop on a T2-weighted sequence following administration of a superparamagnetic iron-oxide agent (SHU 555A).
  • A hepatocellular adenoma was the initial radiological diagnosis.
  • To the best of our knowledge, this is the first report of a histopathologically proven intrahepatic EMH evaluated with dynamic- and SPIO-enhanced MRI.
  • [MeSH-major] Adenoma / diagnosis. Hematopoiesis, Extramedullary. Liver / physiology. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Primary Myelofibrosis / physiopathology

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  • (PMID = 18607123.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2627188
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55. Ikota H, Kinjo S, Yokoo H, Nakazato Y: Systematic immunohistochemical profiling of 378 brain tumors with 37 antibodies using tissue microarray technology. Acta Neuropathol; 2006 May;111(5):475-82
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  • Our TMA consisted of a grid of 1.5-mm cores that were extracted from individual donor blocks.
  • We used hierarchical clustering analysis to interpret these data, which resulted in separation of all the brain tumors into seven groups.
  • Although there were some exceptions, cases with the same histological diagnosis were generally grouped together.
  • We then carried out statistical analyses to find the most useful antibodies for grouping of brain tumors.
  • Six antibodies [EMA, AE1/AE3, TUJ1, nestin, neurofilament protein-MH (NF-MH) and perivascular cells GP-1] showed significant differences between high-grade and low-grade gliomas.
  • [MeSH-major] Antibodies / immunology. Astrocytoma / immunology. Brain Neoplasms / immunology. Immunohistochemistry / methods. Oligodendroglioma / immunology. Protein Array Analysis / methods
  • [MeSH-minor] Aquaporin 4 / immunology. Aquaporin 4 / metabolism. Basic Helix-Loop-Helix Transcription Factors / immunology. Basic Helix-Loop-Helix Transcription Factors / metabolism. Biomarkers, Tumor / immunology. Biomarkers, Tumor / metabolism. Cluster Analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / immunology. Glial Fibrillary Acidic Protein / metabolism. Humans. Intermediate Filament Proteins / immunology. Intermediate Filament Proteins / metabolism. Mucin-1 / immunology. Mucin-1 / metabolism. Nerve Tissue Proteins / immunology. Nerve Tissue Proteins / metabolism. Nestin. Prognosis. Vimentin / immunology. Vimentin / metabolism

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  • (PMID = 16598485.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / AQP4 protein, human; 0 / Antibodies; 0 / Aquaporin 4; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Mucin-1; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / OLIG2 protein, human; 0 / Vimentin; 0 / alpha-internexin
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56. Chia WK, Sharifah NA, Reena RM, Zubaidah Z, Clarence-Ko CH, Rohaizak M, Naqiyah I, Srijit D, Hisham AN, Asmiati A, Rafie MK: Fluorescence in situ hybridization analysis using PAX8- and PPARG-specific probes reveals the presence of PAX8-PPARG translocation and 3p25 aneusomy in follicular thyroid neoplasms. Cancer Genet Cytogenet; 2010 Jan 1;196(1):7-13
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  • [Title] Fluorescence in situ hybridization analysis using PAX8- and PPARG-specific probes reveals the presence of PAX8-PPARG translocation and 3p25 aneusomy in follicular thyroid neoplasms.
  • At the present time, the differentiation between follicular thyroid carcinoma (FTC) and adenoma can be made only postoperatively and is based on the presence of capsular or vascular invasion.
  • The ability to differentiate preoperatively between the malignant and benign forms of follicular thyroid tumors assumes greater importance in any clinical setting.
  • In this study, a group of 60 follicular thyroid neoplasms [18 FTC, 1 Hurthle cell carcinoma (HCC), 24 follicular thyroid adenomas (FTA), 5 Hurthle cell adenomas (HCA), and 12 follicular variants of papillary thyroid carcinomas (FV-PTC)] were analyzed to determine the prevalence of the PAX8-PPARG translocation by fluorescence in situ hybridization.
  • In addition, 2/18 (11.1%) FTC and 1/5 (20%) HCA showed 3p25 aneusomy only.

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  • (PMID = 19963130.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Molecular Probes; 0 / PAX8 protein, human; 0 / PPAR gamma; 0 / Paired Box Transcription Factors
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57. Davis RA, Innocenti A, Poulsen SA, Supuran CT: Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library. Bioorg Med Chem; 2010 Jan 1;18(1):14-8
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  • We have investigated the enzyme inhibition characteristics of a natural product (NP)-based phenolic library against a panel of human carbonic anhydrases (hCAs, EC 4.2.1.1) which included hCAs I and II (cytosolic) and hCA VA/VB (mitochondrial isoforms).
  • Most of these compounds were weak, micromolar inhibitors of the two cytosolic hCAs (K(I)s >10 microM) but showed good hCA VA/VB inhibitory activity with inhibition constants in the range of 70-125 nM.
  • The selectivity ratios for inhibiting the mitochondrial over the cytosolic isoforms for these phenol derivatives were in the range of 120-3800, making them the most isoform-selective compounds for inhibiting hCA VA/VB known to date.
  • Thus the NP inhibitors identified during these studies are excellent leads for obtaining even more effective compounds that selectively target mitochondrial hCAs, and also have the potential to be used as tools for understanding the physiological processes that are regulated by the two mitochondrial CA isoforms.

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19962903.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Phenols; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / Carbonic Anhydrases
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58. Mehrabi M, Ghobadi S, Khodarahmi R: Spectroscopic study on the interaction of celecoxib with human carbonic anhydrase II: thermodynamic characterization of the binding process. J Photochem Photobiol B; 2009 Dec 2;97(3):161-8
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  • The effect of celecoxib, a sulfonamide drug, on the structure and function of human carbonic anhydrase II (hCA II) was investigated by various spectroscopic techniques such as UV-Vis, fluorescence and circular dichroism (CD) spectroscopy and differential scanning calorimetry (DSC), in 20 mM Tris, pH 7.75 at 27 degrees C.
  • Kinetic results revealed that celecoxib inhibits the esterase activity of hCA II in a linear competitive manner with K(i) = 61.61 + or -3.05 nM.
  • Stern-Volmer analysis of quenching data at different temperatures elucidated that the quenching of intrinsic fluorescence of hCA II is occurred through a static quenching mechanism.
  • Analysis of the thermodynamic parameters of binding showed that hydrogen bonding and hydrophobic interactions play the major role in stabilization of the enzyme-drug complex.
  • The Job's plot confirmed the existence of one binding site for celecoxib in hCA II.
  • The far- and near-UV CD experiments indicated that celecoxib causes a little increment in alpha-helicity content of hCA II whereas its flexibility is decreased somewhat upon celecoxib binding.

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  • [ErratumIn] J Photochem Photobiol B. 2010 Mar 8;98(3):225
  • (PMID = 19879770.001).
  • [ISSN] 1873-2682
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anilino Naphthalenesulfonates; 0 / Cyclooxygenase 2 Inhibitors; 0 / Fluorescent Dyes; 0 / Pyrazoles; 0 / Sulfonamides; 82-76-8 / 1-anilino-8-naphthalenesulfonate; EC 4.2.1.- / Carbonic Anhydrase II; JCX84Q7J1L / Celecoxib
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59. Brennan G, McSherry R: Exploring the transition and professional socialisation from health care assistant to student nurse. Nurse Educ Pract; 2007 Jul;7(4):206-14
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  • BACKGROUND: Minimal research is available examining the socialisation process from the perspective of students with health care knowledge who prior to undertaking their training worked as a health care assistant (HCA).
  • The transition and professional socialisation process undertaken by students is an important factor in contributing to the successful completion of a pre-registration nursing programme.
  • OBJECTIVE: The studies aim was to determine the transitional processes associated with moving from a HCA to Student Nurse.
  • POPULATION, SAMPLE, SETTING: A homogeneous sample of 14 students with previous experience as a HCA within the field of adult nursing was used.
  • ] thematic content analysis.
  • Equally a new concept is introduced from the findings, that of 'the comfort zone', which explores the intentional reversal into the HCA role by the participants of the study.
  • From the findings a framework for the transition and professional socialisation from HCA to student nurse is provided.

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  • (PMID = 17689446.001).
  • [ISSN] 1873-5223
  • [Journal-full-title] Nurse education in practice
  • [ISO-abbreviation] Nurse Educ Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. He F, Lin L, Zhao S, Zhao S, Chen S, Wang X: [Fast formation of biomimetic apatite coatings on pure porous titanium implant's surface]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2007 Aug;24(4):806-11
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  • The aim of this study was to elaborate a dense, strong and thin calcium-phosphate coating on commercial porous pure titanium implant surface in the light of a fast biomimetic procedure.
  • A thin calcium-phosphate coating was deposited on all the specimens of the two groups, the surface consisted of well-formed crystals, which were proved to be the mixture of hydroxycarbonated apatite (HCA) and octacalcium phosphate (OCP); the coating's Ca/P rate was 1.51.

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  • (PMID = 17899750.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Calcium Phosphates; 0 / Coated Materials, Biocompatible; D1JT611TNE / Titanium
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61. Loewy EH: Age discrimination at its best: should chronological age be a prime factour in medical decision making? Health Care Anal; 2005 Jun;13(2):101-17
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  • This paper briefly reviews the papers in this special section of HCA and makes the point--a point which should be obvious--that statistics are useful only as guidelines but tell one nothing about the individual patient in front of you.
  • To ration on the basis of age alone is unfair to the individual denied treatment and damaging to the community because it disturbs the solidarity which comes about because most members of the community feel that the community has obligations beyond those of not directly harming them; indeed, what produces solidarity is the feeling that members of a community will do their best to come to each others help.
  • It is pointed out that what matters is a patient's disease and not his/her age.

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  • (PMID = 16013524.001).
  • [ISSN] 1065-3058
  • [Journal-full-title] Health care analysis : HCA : journal of health philosophy and policy
  • [ISO-abbreviation] Health Care Anal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] KIE/ 123470
  • [Keywords] KIE ; Analytical Approach / Health Care and Public Health
  • [General-notes] KIE/ 20 fn.; KIE/ KIE Bib: patien care/aged; resource allocation; selection for treatment
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62. Carestiato FN, Silva KC, Dimetz T, Oliveira LH, Cavalcanti SM: Prevalence of human papillomavirus infection in the genital tract determined by hybrid capture assay. Braz J Infect Dis; 2006 Oct;10(5):331-6
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  • [Title] Prevalence of human papillomavirus infection in the genital tract determined by hybrid capture assay.
  • Recently developed, the second generation of the hybrid capture test (HCA II) is a non-radioactive, relatively rapid, hybridization assay, designed to detect 18 HPV types divided into high and low-risk groups.
  • We evaluated 7,314 patients (5,833 women and 1,481 men) for HPV infection by HCA II.
  • Because of high costs, the HCA II test cannot be recommended for routine mass screening for cervical infection in poor countries.
  • These findings point to the need for close and careful management of patients, thereby reducing overtreatment, allowing analysis of both sexual partners and finally contributing to the control of genital infections associated with a risk for cancer.
  • [MeSH-minor] Adolescent. Adult. Aged. Brazil / epidemiology. Child. DNA, Viral / analysis. Female. Humans. Male. Middle Aged. Prevalence. Risk Factors. Viral Load

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  • (PMID = 17293921.001).
  • [ISSN] 1413-8670
  • [Journal-full-title] The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
  • [ISO-abbreviation] Braz J Infect Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / DNA, Viral
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63. Tustian W: Allowing HCAs to develop is good for patients and nurses. Nurs Stand; 2006 Sep 20;21(2):30-31
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  • [Title] Allowing HCAs to develop is good for patients and nurses.
  • As a former HCA about to begin my second year of nurse training, I was disappointed to read David Salvage's views on caring responsibilities (reflections August 30).

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  • (PMID = 28086506.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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64. Ananiadou OG, Drossos GE, Bibou KN, Palatianos GM, Johnson EO: Acute regional neuronal injury following hypothermic circulatory arrest in a porcine model. Interact Cardiovasc Thorac Surg; 2005 Dec;4(6):597-601
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  • [Title] Acute regional neuronal injury following hypothermic circulatory arrest in a porcine model.
  • OBJECTIVES: Although deep hypothermic circulatory arrest (HCA) is routinely used to interrupt normal perfusion of the brain and prevent subsequent cerebral ischemic injury during cardiac surgery, it is associated with various forms of neurologic disturbances.
  • Neurologic sequelae after prolonged HCA include motor, memory and cognitive deficits.
  • The present study was designed to assess acute regional neuronal injury after HCA in an animal model.
  • METHODS: Six piglets underwent 75 min of HCA at 18 degrees C.
  • Regional patterns of neuronal apoptosis after HCA was characterized by in situ DNA fragmentation using terminal deoxyneucleotidyl-transferase-mediated biotin-dUTP nick end-labeling (TUNEL) histochemistry.
  • Hematoxylin and eosin histology was used to characterize cell damage morphologically.
  • TUNEL-positive cells were scored on a scale of 0 to 5.
  • Grade 0: no TUNEL-positive cells; Grade 1: <10%, Grade 2: 10-25%, Grade 3: 25-50%, Grade 4: 50-75%; and Grade 5: >75%.
  • RESULTS: TUNEL-positive cells indicating DNA-fragmentation were scored in the precentral gyrus (motor neocortex), postcentral gyrus (sensory neocortex), hippocampus, cerebellum, thalamus and ventral medulla of HCA treated animals and were significantly greater than in normal controls (P<or=0.05).
  • Significantly higher concentrations of TUNEL-positive cells were observed in the sensory and motor neocortex and hippocampus, compared to the cerebellum, thalamus and medulla, indicating an increased selective vulnerability of these brain subregions (P<or=0.05).
  • Despite significant DNA fragmentation indicated by high-concentrations TUNEL-positive cells, no morphologic evidence of apoptosis or necrosis was observed in this acute model.
  • CONCLUSION: The data indicate that sensory and motor neocortex and hippocampal neurons are selectively vulnerable to neurologic injury after HCA as indicated by elevated levels of TUNEL-positive cells in these brain regions.
  • The absence of morphological evidence of apoptosis or necrosis with high levels of TUNEL-positive cells, strongly suggests activation of the apoptotic mechanisms at this early stage.

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  • (PMID = 17670490.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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65. Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD: Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol; 2009 May;29(5):739-45
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  • OBJECTIVE: Hydrogen peroxide (H2O2) is an endothelium-derived hyperpolarizing factor in human coronary arterioles (HCAs).
  • Superoxide and H2O2 production was assayed in HCAs and human coronary artery endothelial cells (HCAECs) using dihydroethidium and dichlorodihydrofluorescein histofluorescence, respectively.
  • Diameter changes of HCAs were measured by videomicroscopy.
  • NADPH oxidase subunits Nox1, Nox2, Nox4, p22, p47, and p67 were each expressed in HCA endothelium.
  • In HCAs or HCAECs incubated with dihydroethidium and dichlorodihydrofluorescein, BK induced superoxide and H2O2 formation, which was inhibited by gp91ds-tat or apocynin but not by gp91scram-tat or rotenone.
  • HPLC analysis confirmed that BK specifically induced superoxide production.
  • CONCLUSION: We conclude that endothelial NADPH oxidase is a functionally relevant source of H2O2 that mediates agonist-induced dilation in the human heart.

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  • (PMID = 19213944.001).
  • [ISSN] 1524-4636
  • [Journal-full-title] Arteriosclerosis, thrombosis, and vascular biology
  • [ISO-abbreviation] Arterioscler. Thromb. Vasc. Biol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL68769; United States / NHLBI NIH HHS / HL / R01 HL080704; United States / NHLBI NIH HHS / HL / R01 HL080704-04; United States / NHLBI NIH HHS / HL / P01 HL068769; United States / NHLBI NIH HHS / HL / HL080704-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] BBX060AN9V / Hydrogen Peroxide; EC 1.6.3.1 / NADPH Oxidase; S8TIM42R2W / Bradykinin
  • [Other-IDs] NLM/ NIHMS126047; NLM/ PMC2727937
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66. Gil MV, Calvo LF, Blanco D, Sánchez ME: Assessing the agronomic and environmental effects of the application of cattle manure compost on soil by multivariate methods. Bioresour Technol; 2008 Sep;99(13):5763-72
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  • Multivariate analysis was used for interpreting data from a pot experiment using samples of three Spanish soils.
  • Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were used; they perfectly differentiated sample groups both as a function of the treatment applied and by sampling date.
  • Multivariate methods may therefore be useful for the analysis and interpretation of a large number of data in soil research.
  • [MeSH-minor] Animals. Cattle. Cluster Analysis. Environmental Monitoring / methods. Multivariate Analysis. Spain

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  • (PMID = 18036814.001).
  • [ISSN] 0960-8524
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Manure; 0 / Soil
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67. Waldkirch E, Uckert S, Schultheiss D, Geismar U, Bruns C, Scheller F, Jonas U, Becker AJ, Stief CG, Hedlund P: Non-genomic effects of androgens on isolated human vascular and nonvascular penile erectile tissue. BJU Int; 2008 Jan;101(1):71-5; discussion 75
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  • OBJECTIVES: To evaluate non-genomic effects of testosterone and dihydrotestosterone (DHT) on isolated human cavernosal arteries (HCA) and corpus cavernosum (HCC) using organ-bath studies and radio-immunoassays (RIA), as non-genomic effects of androgens are reported for vascular smooth musculature and there is evidence that the relaxant response involves a modulation of cyclic nucleotide tissue levels.
  • MATERIALS AND METHODS: The relaxation induced by the cumulative addition of testosterone and DHT (0.01-10 microm) was studied using circular segments of HCA and strip preparations of HCC.
  • CONCLUSION: Rapid androgen-induced relaxation of HCA and HCC occurs via non-genomic mechanisms.

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  • (PMID = 17868421.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 08J2K08A3Y / Dihydrotestosterone; 3XMK78S47O / Testosterone; E0399OZS9N / Cyclic AMP; H2D2X058MU / Cyclic GMP
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68. Psatha EA, Semelka RC, Armao D, Woosley JT, Firat Z, Schneider G: Hepatocellular adenomas in men: MRI findings in four patients. J Magn Reson Imaging; 2005 Aug;22(2):258-64
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  • [Title] Hepatocellular adenomas in men: MRI findings in four patients.
  • PURPOSE: To demonstrate both MRI and histopathological findings of hepatocellular adenomas (HCAs) in men.
  • MATERIALS AND METHODS: HCAs in four men are reported.
  • RESULTS: Three men had solitary non-hemorrhagic adenomas that exhibited a uniform capillary blush with no central scar, and uniform fading of the tumor to near isointensity with the liver parenchyma by one minute.
  • One patient had a solitary hemorrhagic adenoma that measured 17 cm in diameter and was heterogeneous on all sequences.
  • CONCLUSIONS: Although three of the four patients had tumors that exhibited uniform homogeneous tumor blush and rapid fading of enhancement, because HCAs are rare in men and resemble hepatocellular carcinoma (HCC) in appearance, our findings suggest that histological confirmation of HCAs may not be avoidable in men.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis. Radiographic Image Enhancement
  • [MeSH-minor] Adolescent. Adult. Biopsy, Needle. Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Humans. Immunohistochemistry. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16028257.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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69. Bicknell DC, Bodmer WF: A mutated HLA-A*0101 allele in the colorectal cell line HCA-7. Tissue Antigens; 2005 Sep;66(3):231-7
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  • [Title] A mutated HLA-A*0101 allele in the colorectal cell line HCA-7.
  • The colorectal cell line HCA-7 expresses surface human leucocyte antigen-A*0201 (HLA-A*0201), but lacks expression of HLA-A*0101 whilst the normal B-cell line (EVA-1224), derived from the same individual, expresses both surface HLA-A1 and HLA-A2.
  • Amplification refractory mutation system-polymerase chain reaction analysis, using sequence-specific primers, suggested that HCA-7 has a mutation in a 7 base pair (bp) cytosine repeat sequence located at the beginning of Exon 4 (bp 621-627).
  • Cloning and sequencing revealed HCA-7 to have eight cytosine residues in this repeat sequence.
  • Analysis of the mRNA for HLA-A*010 using reverse trancriptase-polymerase chain reaction (RT-PCR), with an allele-specific 5' primer in exon 2 (bp 253-271) and a series of 3' primers in exons 3, 4 and 7 and in the 3'untranslated region, revealed that HCA-7 contained a shortened message terminating in the region of the exon 3/4 boundary.
  • The insertion of an extra cytosine in this region, which is only two bases from the exon 3/4 splice site, is presumed to lead to a splicing defect between exons 3 and 4 resulting in the lack of expression of a functional HLA-A*0101 product.
  • HCA-7 is mismatch repair (MMR) defective due to lack of expression of hMLH1 resulting from hypermethylation of the promoter region.
  • [MeSH-minor] 3' Untranslated Regions. Alleles. Base Pair Mismatch. Cell Line, Tumor. Cloning, Molecular. Cytosine. DNA / metabolism. DNA Primers / genetics. DNA Repair. Exons. Gene Frequency. HLA-A1 Antigen. HLA-A2 Antigen. Humans. Isoelectric Focusing. Polymerase Chain Reaction. Promoter Regions, Genetic. RNA / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sequence Analysis, DNA

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  • (PMID = 16101834.001).
  • [ISSN] 0001-2815
  • [Journal-full-title] Tissue antigens
  • [ISO-abbreviation] Tissue Antigens
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / DNA Primers; 0 / HLA-A Antigens; 0 / HLA-A*01:01 antigen; 0 / HLA-A*02:01 antigen; 0 / HLA-A1 Antigen; 0 / HLA-A2 Antigen; 63231-63-0 / RNA; 8J337D1HZY / Cytosine; 9007-49-2 / DNA
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70. Galloro V: HCA initiates Texas two-step. Allegations spur Baylor joint-venture investigations. Mod Healthc; 2006 May 15;36(20):8-10
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  • [Title] HCA initiates Texas two-step. Allegations spur Baylor joint-venture investigations.

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  • (PMID = 16752858.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] Legal Cases; News
  • [Publication-country] United States
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71. Galloro V: LifePoint rethinks HCA deal. Renegotiations are under way for five hospitals. Mod Healthc; 2006 Apr 10;36(15):8-9
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  • [Title] LifePoint rethinks HCA deal. Renegotiations are under way for five hospitals.

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  • (PMID = 16671188.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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72. Shirley Law. Nurs Older People; 2009 Mar 11;21(2):16
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  • Shirley is currently seconded to the Dementia Services Development Centre (DSDC) at the University of Stirling where she is project manager for an innovative RCN-accredited study programme for healthcare assistants (HCAs) working in hospitals and care homes.
  • By the end of its first year, 800 HCAs had undertaken the programme throughout the UK.

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  • (PMID = 27745086.001).
  • [ISSN] 1472-0795
  • [Journal-full-title] Nursing older people
  • [ISO-abbreviation] Nurs Older People
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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73. Becker C: HCA's private ambitions. What twists could the industry expect this time? Mod Healthc; 2006 Jul 31;36(30):8-9, 16
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  • [Title] HCA's private ambitions. What twists could the industry expect this time?

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  • (PMID = 16913009.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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74. Ueda Y: What is the best method for brain protection in surgery of the aortic arch? Retrograde cerebral perfusion. Cardiol Clin; 2010 May;28(2):371-9
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  • The technical simplicity of retrograde cerebral perfusion (RCP) together with a highly favorable effect upon stroke rates and survival after aortic arch surgery justifies continued clinical use of RCP in patients requiring hypothermic circulatory arrest (HCA), in particular patients with dissecting or atheromatous arch branches.
  • In clinical practice, using RCP can provide effective brain protection in HCA for about 40 to 60 minutes, although there is a time limitation.
  • [MeSH-major] Aorta, Thoracic / surgery. Aortic Aneurysm, Thoracic / surgery. Cerebrovascular Circulation / physiology. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Perfusion / methods. Stroke / prevention & control. Vascular Surgical Procedures / methods

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Cardiol Clin. 2010 May;28(2):403-4 [20452559.001]
  • (PMID = 20452556.001).
  • [ISSN] 1558-2264
  • [Journal-full-title] Cardiology clinics
  • [ISO-abbreviation] Cardiol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 39
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75. White CD, Khurana H, Gnatenko DV, Li Z, Odze RD, Sacks DB, Schmidt VA: IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. BMC Gastroenterol; 2010;10:125
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  • [Title] IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma.
  • We recently reported that IQGAP2 deficiency leads to the development of hepatocellular carcinoma (HCC) in mice.
  • IQGAP mRNA was measured by quantitative RT-PCR.
  • RESULTS: IQGAP1 and IQGAP2 expression was reciprocally altered in 6/6 liver cancer cell lines.
  • No IQGAP1 staining was detected in 23/28 (82.1%) normal livers, 4/4 (100.0%) hepatic adenomas and 23/23 (100.0%) cirrhosis cases, while IQGAP2 was increased in 22/28 (78.6%), 4/4 (100.0%) and 23/23 (100.0%), respectively.
  • Immunostaining of IQGAP1 and IQGAP2 may aid in the diagnosis of HCC, and their pharmacologic modulation may represent a novel therapeutic strategy for the treatment of liver cancer.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. DNA, Neoplasm / genetics. Gene Expression Regulation, Neoplastic. Liver Neoplasms / genetics. ras GTPase-Activating Proteins / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Blotting, Western. Female. Genetic Predisposition to Disease. Humans. Immunohistochemistry. Male. Middle Aged. Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 20977743.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / IQ motif containing GTPase activating protein 1; 0 / IQGAP2 protein, human; 0 / ras GTPase-Activating Proteins
  • [Other-IDs] NLM/ PMC2988069
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76. Ao L, Liu JY, Liu WB, Gao LH, Hu R, Fang ZJ, Zhen ZX, Huang MH, Yang MS, Cao J: Comparison of gene expression profiles in BALB/c 3T3 transformed foci exposed to tumor promoting agents. Toxicol In Vitro; 2010 Mar;24(2):430-8
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  • In this study, cDNA microarrays were used to analyze gene expression and discern chemical-associated profiles induced by a variety of tumor promoting agents in transformed cells.
  • Two-stage transformation model of BALB/c 3T3 cells was established with MNNG as initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid (OA), or cadmium chloride (CdCl(2)) as tumor promoters.
  • Nine morphologically transformed foci were isolated and the anchorage-independent growth of transformed cells was verified.
  • Unsupervised hierarchical clustering analysis revealed that the nine foci were classified into three groups in concordance with the promoters used to induce them and characteristic clusters of genes were identified.
  • Moreover, common gene expression alterations were also observed in foci, including upregulated genes associated with cell proliferation and downregulated genes associated with extracellular matrix.
  • Our results demonstrate the presence of unique gene expression profiles in transformed cells which reflect the etiological chemicals and indicate the importance of characteristic molecular alterations as potential biomarkers of exposure to tumor promoters.
  • [MeSH-minor] Animals. BALB 3T3 Cells. Cell Proliferation / drug effects. Extracellular Matrix. Mice. Protein Array Analysis. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19840844.001).
  • [ISSN] 1879-3177
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 1W21G5Q4N2 / Okadaic Acid; J6K4F9V3BA / Cadmium Chloride; NI40JAQ945 / Tetradecanoylphorbol Acetate
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77. Franco LM, Krishnamurthy V, Bali D, Weinstein DA, Arn P, Clary B, Boney A, Sullivan J, Frush DP, Chen YT, Kishnani PS: Hepatocellular carcinoma in glycogen storage disease type Ia: a case series. J Inherit Metab Dis; 2005;28(2):153-62
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  • [Title] Hepatocellular carcinoma in glycogen storage disease type Ia: a case series.
  • We present a series of 8 patients (6 males, 2 females) with hepatocellular carcinoma (HCC) and glycogen storage disease type Ia (GSD Ia).
  • Hepatic masses were first detected at an age range of 13-45 years (mean 28.1 years).
  • Age at diagnosis of HCC ranged from 19 to 49 years (mean 36.9 years).
  • Duration between the diagnosis of liver adenomas and the diagnosis of HCC ranged from 0 to 28 years (mean 8.8 years, SD = 11.5).
  • Current guidelines recommend abdominal ultrasonography with AFP and CEA levels every 3 months once patients develop hepatic lesions.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Glycogen Storage Disease Type I / complications. Liver Neoplasms / etiology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / etiology. Adult. Aged. Aged, 80 and over. Biomarkers. Carcinoembryonic Antigen / blood. Child. Child, Preschool. Female. Humans. Male. Prognosis. Tomography, X-Ray Computed. Ultrasonography. alpha-Fetoproteins / metabolism

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  • (PMID = 15877204.001).
  • [ISSN] 0141-8955
  • [Journal-full-title] Journal of inherited metabolic disease
  • [ISO-abbreviation] J. Inherit. Metab. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Carcinoembryonic Antigen; 0 / alpha-Fetoproteins
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78. Wang D, Lagerstrom R, Sun C, Bishof L, Valotton P, Götte M: HCA-vision: Automated neurite outgrowth analysis. J Biomol Screen; 2010 Oct;15(9):1165-70
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  • [Title] HCA-vision: Automated neurite outgrowth analysis.
  • Automating the analysis of neurons in culture represents a key aspect of the search for neuroactive compounds.
  • A number of commercial neurite analysis software packages tend to measure some basic features such as total neurite length and number of branching points.
  • The authors have developed a suite of image analysis tools that will allow researchers to produce quality analyses at primary screening rates.
  • In mixed cell populations, neurons can be filtered and separated from other brain cell types so that neurite analysis can be performed only on neurons.
  • It supports batch processing with a built-in database to store the batch-processing results, a batch result viewer, and an ad hoc query builder for users to retrieve features of interest.
  • The suite of tools has been deployed into a software package called HCA-Vision.
  • The free version of the software package is available at http://www.hca-vision.com.

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  • (PMID = 20855562.001).
  • [ISSN] 1552-454X
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
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79. Güzel O, Innocenti A, Hall RA, Scozzafava A, Mühlschlegel FA, Supuran CT: Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem; 2009 Apr 15;17(8):3212-5
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  • Some of these sulfonamides also showed a good selectivity profile for the inhibition of the nematode over the human isozymes CA I and II (selectivity ratios in the range of 1.78-4.95 for the inhibition of ceCA over hCA II).

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  • (PMID = 19201197.001).
  • [ISSN] 1464-3391
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0601049; United Kingdom / Biotechnology and Biological Sciences Research Council / / ; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Hydrazines; 0 / Indoles; 0 / Isoenzymes; 0 / Sulfonamides; EC 4.2.1.1 / Carbonic Anhydrases
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80. Lee BH, Seong J, Kim UJ, Won R, Kim J: Behavioral characteristics of a mouse model of cancer pain. Yonsei Med J; 2005 Apr 30;46(2):252-9
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  • [Title] Behavioral characteristics of a mouse model of cancer pain.
  • Murine hepatocarcinoma cells, HCa-1, were inoculated unilaterally into the thigh or the dorsum of the foot of male C3H/HeJ mice.
  • Bone invasion by the tumor commenced from 7 days after inoculation of tumor cells and was evident from 14 days after inoculation.
  • These results suggest that carcinoma cells injected into the foot of mice may develop severe chronic pain related to cancer.
  • [MeSH-minor] Animals. Bone and Bones / pathology. Carcinoma, Hepatocellular / pathology. Cell Line, Tumor. Cold Temperature. Disease Models, Animal. Foot. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred C3H. Neoplasm Invasiveness. Neoplasm Transplantation. Pain Threshold. Physical Stimulation. Thigh

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  • (PMID = 15861499.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2823022
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81. Fioole B, Kokke M, van Hillegersberg R, Rinkes IH: Adequate symptom relief justifies hepatic resection for benign disease. BMC Surg; 2005;5:7
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  • [Title] Adequate symptom relief justifies hepatic resection for benign disease.
  • BACKGROUND: The purpose of this study was to evaluate the long-term results of partial liver resection for benign liver lesions.
  • METHODS: All patients operated on for benign liver lesions from 1991 to 2002 were included.
  • The diagnosis was haemangioma in 8 patients, FNH in 6, HCA in 13 and angiomyolipoma in 1.
  • CONCLUSION: Long-term follow up after liver surgery for benign liver lesions shows considerable symptom relief and patient satisfaction.
  • [MeSH-major] Angiomyolipoma / surgery. Focal Nodular Hyperplasia / surgery. Hemangioma / surgery. Liver / surgery. Liver Neoplasms / surgery. Postoperative Complications

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  • (PMID = 15804352.001).
  • [ISSN] 1471-2482
  • [Journal-full-title] BMC surgery
  • [ISO-abbreviation] BMC Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1087495
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82. Zhang YZ, Shen Y, Wang LF, Ding WY, Xu JX, He J: Magnetic resonance T2 image signal intensity ratio and clinical manifestation predict prognosis after surgical intervention for cervical spondylotic myelopathy. Spine (Phila Pa 1976); 2010 May 1;35(10):E396-9
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  • The means of quantizing SI ratio for the disease has not been discussed.
  • All patients had been divided into 3 groups by hierarchical clustering analysis with SI ratio (Group 1: low SI ratio, Group 2: middle SI ratio, and Group 3: high SI ratio).
  • Statistical analyses were performed with SPSS 11.0.
  • RESULTS: There are significant differences between 3 groups by comparing the recovery rate (P < 0.001), age (P = 0.003), duration of disease (P = 0.001), Babinski sign (P < 0.001), preoperative JOA score (P = 0.006), and postoperative JOA score (P < 0.001).
  • By using the multiple comparison analysis, the above results are further shown.
  • CONCLUSION: Patients with low SI ratio who were not too old and had a shorter duration of disease experienced a good surgical outcome.

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  • (PMID = 20393392.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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83. Smaine FZ, Pacchiano F, Rami M, Barragan-Montero V, Vullo D, Scozzafava A, Winum JY, Supuran CT: Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. Bioorg Med Chem Lett; 2008 Dec 15;18(24):6332-5
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  • The new compounds showed weak inhibitory activity against hCA I (K(I)s of 102 nM-7.42 microM), hCA II (K(I)s of 0.54-7.42 microM) and hCA IV (K(I)s of 4.32-10.05 microM) but were low nanomolar inhibitors of hCA VA and hCA VB, with inhibition constants in the range of 4.2-32 nM and 1.3-74 nM, respectively.

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  • (PMID = 18990571.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Thiadiazoles; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.- / Carbonic Anhydrase IV; EC 4.2.1.- / Carbonic Anhydrase V
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84. Maupin CM, Voth GA: Preferred orientations of His64 in human carbonic anhydrase II. Biochemistry; 2007 Mar 20;46(11):2938-47
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  • Histidine at position 64 (His64) in human carbonic anhydrase II (HCA II) is believed to be the proton acceptor in the hydration direction and the proton donor in the dehydration direction for the rate-limiting proton transfer (PT) event.
  • X-ray data of HCA II suggests that His64 can adopt either an "in" or "out" orientation.
  • In the present work, classical molecular dynamics simulations have been conducted to elucidate the role that the His64 orientation may play in its ability to act as a proton donor/acceptor in HCA II.

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  • (PMID = 17319695.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / 1 S10 RR17214-01; United States / NIGMS NIH HHS / GM / R01 GM053148; United States / NIGMS NIH HHS / GM / GM053148-13; United States / NIGMS NIH HHS / GM / GM53148; United States / NIGMS NIH HHS / GM / R01 GM053148-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 4QD397987E / Histidine; EC 4.2.1.- / Carbonic Anhydrase II
  • [Other-IDs] NLM/ NIHMS61946; NLM/ PMC2569863
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85. Elder I, Tu C, Ming LJ, McKenna R, Silverman DN: Proton transfer from exogenous donors in catalysis by human carbonic anhydrase II. Arch Biochem Biophys; 2005 May 1;437(1):106-14
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  • In the site-specific mutant of human carbonic anhydrase in which the proton shuttle His64 is replaced with alanine, H64A HCA II, catalysis can be activated in a saturable manner by the proton donor 4-methylimidazole (4-MI).
  • From 1H NMR relaxivities, we found 4-MI bound as a second-shell ligand of the tetrahedrally coordinated cobalt in Co(II)-substituted H64A HCA II, with 4-MI located about 4.5 A from the metal.
  • Binding constants of 4-MI to H64A HCA II were estimated from:.
  • (1) NMR relaxation of the protons of 4-MI by Co(II)-H64A HCA II, (2) the visible absorption spectrum of Co(II)-H64A HCA II in the presence of 4-MI, (3) the inhibition by 4-MI of the catalytic hydration of CO2, and (4) from the catalyzed exchange of 18O between CO2 and water.

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  • (PMID = 15820222.001).
  • [ISSN] 0003-9861
  • [Journal-full-title] Archives of biochemistry and biophysics
  • [ISO-abbreviation] Arch. Biochem. Biophys.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM 25154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Imidazoles; 0 / Protons; 142M471B3J / Carbon Dioxide; 3G0H8C9362 / Cobalt; EC 4.2.1.- / Carbonic Anhydrase II; Q64GF9FV4I / 4-methylimidazole; S88TT14065 / Oxygen
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86. Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, Izard T, Balabaud C, Bioulac-Sage P, Zucman-Rossi J: Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature; 2009 Jan 8;457(7226):200-4
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  • [Title] Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours.
  • Inflammatory hepatocellular adenomas are benign liver tumours defined by the presence of inflammatory infiltrates and by the increased expression of inflammatory proteins in tumour hepatocytes.
  • Indeed, 60% of inflammatory hepatocellular adenomas harbour small in-frame deletions that target the binding site of gp130 for IL-6, and expression of four different gp130 mutants in hepatocellular cells activates signal transducer and activator of transcription 3 (STAT3) in the absence of ligand.
  • Furthermore, analysis of hepatocellular carcinomas revealed that rare gp130 alterations are always accompanied by beta-catenin-activating mutations, suggesting a cooperative effect of these signalling pathways in the malignant conversion of hepatocytes.
  • The recurrent gain-of-function gp130 mutations in these human hepatocellular adenomas fully explains activation of the acute inflammatory phase observed in tumourous hepatocytes, and suggests that similar alterations may occur in other inflammatory epithelial tumours with STAT3 activation.


87. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 May;(529):4-168
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  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • While one of the aims of this study was a comparative analysis of effects seen with PCB 126 and the mixture of PCB 126 and PCB 153, in this Technical Report only the results of the present study of PCB 153 are presented and discussed.
  • Hepatic Cell Proliferation Data: No significant differences in hepatocellular labeling index were observed between the vehicle control and dosed groups at any of the interim evaluations.
  • Cytochrome P450 Enzyme Activities Hepatic pentoxyresorufin-O-deethylase activities were highly and significantly elevated relative to the vehicle control groups.
  • Hepatic 7-ethoxyresorufin-O-deethylase (EROD) and acetanilide-4-hydroxylase (A4H) activities were significantly elevated over controls at 14 and 31 weeks; increases were less than twofold.
  • In the liver of vehicle controls, no measurable concentrations of PCB 153 were observed at any time point.
  • In dosed groups, hepatic concentrations of PCB 153 increased with increasing dose and longer exposure duration.
  • In liver, lung, and blood of rats from the 3,000 microg/kg stop-exposure group, PCB 153 concentrations were slightly above or below the levels observed in the 1,000 microg/kg group.
  • Organ Weights: Absolute liver weights of 1,000 microg/kg rats and absolute and relative liver weights of 3,000 microg/kg rats were significantly greater than those of vehicle controls at week 14.
  • At week 31, relative liver weights of 1,000 microg/kg rats and absolute and relative liver weights of 3,000 microg/kg rats were significantly greater than those of vehicle controls.
  • At week 53, absolute and relative liver weights were significantly greater in rats administered 100 microg/kg or greater compared to vehicle controls.
  • Pathology and Statistical Analyses: The incidences of hepatocyte hypertrophy were significantly increased in the 1,000 and 3,000 microg/kg groups at 14 weeks and in all groups administered 300 microg/kg or greater at 31 and 53 weeks.
  • The incidences of diffuse fatty change in the 300 microg/kg or greater groups and bile duct hyperplasia of the liver in 300 microg/kg and 3,000 microg/kg (core and stop-exposure) groups were significantly increased.
  • The incidences of oval cell hyperplasia and pigmentation of the liver were significantly increased in the 3,000 microg/kg core study group.
  • A single hepatocellular adenoma was observed in the 3,000 microg/kg core study group.
  • At 53 weeks, sporadic incidences of minimal to mild follicular cell hypertrophy of the thyroid gland occurred in all groups (except 10 microg/kg).
  • At 2 years, the incidences of minimal to mild follicular cell hypertrophy were significantly increased in the 300 microg/kg and 3,000 microg/kg (core and stop-exposure) groups.
  • CONCLUSIONS: Under the conditions of this 2-year gavage study there was equivocal evidence of carcinogenic activity of PCB 153 in female Harlan Sprague-Dawley rats based on the occurrences of cholangioma of the liver.
  • PCB 153 administration caused increased incidences of nonneoplastic lesions of the liver, thyroid gland, ovary, oviduct, and uterus in female rats.
  • [MeSH-minor] Adenoma, Bile Duct / chemically induced. Adenoma, Bile Duct / pathology. Administration, Oral. Animals. Bile Duct Neoplasms / chemically induced. Bile Duct Neoplasms / pathology. Cell Enlargement / drug effects. Cell Proliferation / drug effects. Dose-Response Relationship, Drug. Female. Hepatocytes / drug effects. Hepatocytes / pathology. Liver / drug effects. Liver / pathology. Organ Size / drug effects. Rats. Rats, Sprague-Dawley. Thyroid Hormones / blood. Toxicity Tests

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  • (PMID = 16835634.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Thyroid Hormones; DFC2HB4I0K / Polychlorinated Biphenyls; ZRU0C9E32O / 2,4,5,2',4',5'-hexachlorobiphenyl
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88. Mattioli F, Martelli A, Garbero C, Gosmar M, Manfredi V, Mattioli FP, Torre G, Brambilla G: DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens. Toxicol Appl Pharmacol; 2005 Mar 1;203(2):99-105
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  • [Title] DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens.
  • Four chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells.
  • Significant dose-dependent increases in the frequency of DNA single-strand breaks and alkali-labile sites, as measures by the Comet assay, were obtained after a 20-h exposure to the following subtoxic concentrations of the four test compounds: 2,4-diaminoanisole (DAA) from 0.10 to 1.0 mM, 4,4'-methylene-bis(N,N-dimethyl)benzenamine (MDB) from 0.32 to 1.8 mM, propylthiouracil (PTU) from 1.8 to 5.6 mM, and 4,4'-thiodianiline (THA) from 0.032 to 0.18 mM.
  • Consistent with their thyroid-specific carcinogenic activity, all the four chemicals, administered p.o. in rats in a single dose corresponding to 1/2 LD50, induced a statistically significant degree of DNA fragmentation in the thyroid, whereas any substantial evidence of DNA lesions was absent in liver, kidney, and lung, which, with the exception of liver tumors caused by THA, are not targets of the carcinogenic activity of the four test compounds.
  • These findings indicate that the DNA damage observed in thyroid cells was consistent with the carcinogenicity of the four test compounds, and suggest that DAA, MDB, PTU, and THA might be carcinogenic to thyroid in humans.
  • [MeSH-minor] Aniline Compounds / toxicity. Animals. Antithyroid Agents / toxicity. Cells, Cultured. Comet Assay. DNA Repair / drug effects. Humans. Male. Phenylenediamines / toxicity. Propylthiouracil / toxicity. Rats. Rats, Sprague-Dawley

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  • (PMID = 15710170.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Antithyroid Agents; 0 / Carcinogens; 0 / Phenylenediamines; 6GGU990BQF / 4,4'-thiodianiline; 721M9407IY / Propylthiouracil; 86SSM2N1X7 / 4-methoxy-3-phenylenediamine; L6SPP9K4WQ / N,N,N',N'-tetramethyl-4,4'-methylenedianiline
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89. Barreiro CJ, Williams JA, Fitton TP, Lange MS, Blue ME, Kratz L, Barker PB, Degaonkar M, Gott VL, Troncoso JC, Johnston MV, Baumgartner WA: Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy. Ann Thorac Surg; 2006 May;81(5):1593-8
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  • [Title] Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy.
  • BACKGROUND: Studies have confirmed the neuroprotective effect of diazoxide in canines undergoing hypothermic circulatory arrest (HCA).
  • We demonstrated that noninvasive measurement of NAA:Cho with magnetic resonance spectroscopy facilitates assessment of neuronal injury after HCA and allows for evaluation of neuroprotective strategies.
  • METHODS: Canines underwent 2 hours of HCA at 18 degrees C and were observed for 24 hours.
  • Animals were divided into three groups (n = 15 in each group): normal (unoperated), HCA (HCA only), and HCA+diazoxide (pharmacologic treatment before HCA).
  • The NAA:Cho ratios were obtained 24 hours after HCA by spectroscopy.
  • Separate cohorts of HCA (n = 16) and HCA+diazoxide (n = 23) animals were kept alive for 72 hours for daily neurologic assessment.
  • RESULTS: Cortical NAA:Cho ratios were significantly decreased in HCA versus normal animals (1.01 +/- 0.29 versus 1.31 +/- 0.23; p = 0.004), consistent with severe neurologic injury.
  • Diazoxide pretreatment limited neurologic injury versus HCA alone, reflected in a preserved NAA:Cho ratio (1.21 +/- 0.27 versus 1.01 +/- 0.29; p = 0.05).
  • A significant decrease in cortical NAA was observed in HCA versus normal (7.07 +/- 1.9 versus 8.54 +/- 2.1 micromol/g; p = 0.05), with maintenance of normal NAA levels after diazoxide pretreatment (9.49 +/- 1.1 versus 7.07 +/- 1.9 micromol/g; p = 0.0002).
  • Clinical neurologic scores were significantly improved in the HCA+diazoxide group versus HCA at all time points.
  • CONCLUSIONS: Neurologic injury remains a significant complication of cardiac surgery and is most severe after HCA.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced. Hypoxia, Brain / diagnosis. Magnetic Resonance Spectroscopy

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  • (PMID = 16631640.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R37NS31238-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Vasodilator Agents; 30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; N91BDP6H0X / Choline; O5CB12L4FN / Diazoxide
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90. Zucman-Rossi J, Amessou M, Bioulac-Sage P, Rebouissou S: [Gp130-activating mutations in inflammatory liver adenomas]. Med Sci (Paris); 2008 Dec;24(12):1113-4
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  • [Title] [Gp130-activating mutations in inflammatory liver adenomas].
  • [Transliterated title] Identification de mutations activatrices de gp130 dans la tumorigenèse hépatique.
  • [MeSH-major] Adenoma / genetics. Cytokine Receptor gp130 / genetics. Drug-Induced Liver Injury / genetics. Liver Neoplasms / genetics. Neoplasm Proteins / genetics
  • [MeSH-minor] Adult. Carcinoma, Hepatocellular / genetics. Contraceptives, Oral, Hormonal / adverse effects. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Hepatocyte Nuclear Factor 1-alpha / physiology. Humans. Inflammation Mediators / metabolism. Interleukin-6 / physiology. Mutation. STAT3 Transcription Factor / physiology. Sequence Deletion. Wnt Proteins / physiology. Young Adult. beta Catenin / physiology

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  • (PMID = 19116130.001).
  • [ISSN] 0767-0974
  • [Journal-full-title] Médecine sciences : M/S
  • [ISO-abbreviation] Med Sci (Paris)
  • [Language] fre
  • [Publication-type] News; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Contraceptives, Oral, Hormonal; 0 / Hepatocyte Nuclear Factor 1-alpha; 0 / IL6 protein, human; 0 / IL6ST protein, human; 0 / Inflammation Mediators; 0 / Interleukin-6; 0 / Neoplasm Proteins; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / Wnt Proteins; 0 / beta Catenin; 133483-10-0 / Cytokine Receptor gp130
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91. Gu S, Liu Y, Su PX, Zhai ZG, Yang YH, Wang C: Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: preliminary exploration in China. Chin Med J (Engl); 2010 Apr 20;123(8):979-83
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  • Bilateral pulmonary endarterectomy was performed under cardiopulmonary bypass with profound hypothermic circulatory arrest.
  • CONCLUSIONS: Bilateral pulmonary endarterectomy using cardiopulmonary bypass with the aid of deep hypothermia and circulatory arrest can effectively reduce pulmonary hypertension and provide good mid-term hemodynamic and symptomatic results with low surgical mortality rate and few complications.

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  • (PMID = 20497700.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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92. Furuta K, Sato S, Yamauchi T, Ozawa T, Harada M, Kakumu S: Intrahepatic gene expression profiles in chronic hepatitis B and autoimmune liver disease. J Gastroenterol; 2008;43(11):866-74
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  • [Title] Intrahepatic gene expression profiles in chronic hepatitis B and autoimmune liver disease.
  • BACKGROUND: DNA microarray technology has enabled genomewide analysis of gene transcript levels, yielding insight into the molecular nature of liver disease.
  • METHODS: We compared gene expression of liver biopsy specimens in 16 patients with different stages of chronic hepatitis B, five with autoimmune hepatitis (AIH), five with primary biliary cirrhosis (PBC), and six with druginduced hepatitis.
  • RESULTS: Of 21 073 genes, 424 showed different expression in a particular disease group on analysis of variance.
  • Genes associated with extracellular matrix, cell growth, and DNA repair were noted in the advanced fibrotic stage of chronic hepatitis B (B-3), while gene expression regarding complement activation and the innate immune response decreased.
  • When we compared gene expression at the relatively early stage in each disease group with pathway analysis, pathways relating to chemotaxis and cell homeostasis were selected in chronic hepatitis B.
  • A hierarchical clustering analysis of hepatitis B genes defined five clusters.
  • Generally, the transcripts upregulated according to disease progression were associated with signaling pathway/transcription, including tumor-associated calcium signal transducer 1 and chemokine ligand 19, and with cell communication, such as collagen.
  • CONCLUSIONS: Analysis of gene expression in liver may be useful for understanding features of distinct liver diseases and for guiding disease progression, particularly in chronic hepatitis B.
  • [MeSH-major] Antigens, Neoplasm / genetics. Cell Adhesion Molecules / genetics. Chondroitin Sulfate Proteoglycans / genetics. Extracellular Matrix Proteins / genetics. Gene Expression. Hepatitis B, Chronic / genetics. Hepatitis, Autoimmune / genetics. Keratan Sulfate / genetics. RNA / genetics
  • [MeSH-minor] Adult. Biopsy. Disease Progression. Epithelial Cell Adhesion Molecule. Female. Gene Expression Profiling. Genetic Predisposition to Disease. Humans. Liver / metabolism. Liver / pathology. Lumican. Male. Middle Aged. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19012040.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / Chondroitin Sulfate Proteoglycans; 0 / EFEMP1 protein, human; 0 / EPCAM protein, human; 0 / Epithelial Cell Adhesion Molecule; 0 / Extracellular Matrix Proteins; 0 / LUM protein, human; 0 / Lumican; 63231-63-0 / RNA; 9056-36-4 / Keratan Sulfate
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93. Baron D, Houlgatte R, Fostier A, Guiguen Y: Large-scale temporal gene expression profiling during gonadal differentiation and early gametogenesis in rainbow trout. Biol Reprod; 2005 Nov;73(5):959-66
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  • Finding conserved mechanisms among vertebrates should provide a better view of the key factors involved in this process.
  • We used these 102 temporal gene expression patterns as a basis for a hierarchical clustering analysis to find characteristic clusters of coexpressed genes.
  • Analysis of some of these gene clusters suggested a conserved overall expression profile between the sex differentiation cascade in fish and mammals.
  • Apart from this high conservation, our analysis suggests some potential new players, such as the fshb subunit gene, which is detected here for the first time, to our knowledge, in the female differentiating gonad of a vertebrate species and displays a specific overexpression that coincides in timing with the occurrence of first oocyte meioses, or the pax2 gene, which displays an early and testis-specific expression profile.
  • [MeSH-minor] Animals. Cluster Analysis. Female. Male. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16014816.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Wu K, Sinha R, Holmes MD, Giovannucci E, Willett W, Cho E: Meat mutagens and breast cancer in postmenopausal women--a cohort analysis. Cancer Epidemiol Biomarkers Prev; 2010 May;19(5):1301-10
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  • [Title] Meat mutagens and breast cancer in postmenopausal women--a cohort analysis.
  • METHODS: We examined the association between intakes of the heterocyclic amines (HCA) MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline), PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]), and meat-derived mutagenic (MDM) activity and risk of breast cancer using a cooking method questionnaire administered in 1996 in the Nurses' Health Study.
  • RESULTS: Higher intake of HCAs or MDM was not associated with elevated risk of breast cancer [multivariate relative risk and 95% confidence interval for the highest versus lowest quintile: MeIQx: 0.90 (0.79-1.03); PhIP: 0.92 (0.80-1.05); DiMeIQx: 0.92 (0.80-1.05); and MDM: 0.98 (0.85-1.12)].
  • HCA or MDM was not associated with estrogen receptor-positive/progesterone receptor-positive breast cancer risk either.
  • There was some suggestion of a decreased risk of estrogen receptor-negative/progesterone receptor-negative breast cancer with higher intakes of MeIQx, DiMeIQx, and PhIP, but none of the associations were statistically significant.
  • There was little evidence for an interaction between intake of cruciferous vegetables and HCA or MDM intake and risk of breast cancer.
  • IMPACT: Overall prospective data including results from our study do not provide support for a substantial increase in risk of breast cancer with higher intake of HCAs.

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  • Hazardous Substances Data Bank. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine .
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  • [Copyright] Copyright (c) 2010 AACR
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  • (PMID = 20447922.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA055075; United States / NCI NIH HHS / CA / P01 CA087969; United States / NCI NIH HHS / CA / P01 CA087969-12; United States / NCI NIH HHS / CA / CA 55075
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Imidazoles; 0 / Mutagens; 0 / Quinoxalines; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • [Other-IDs] NLM/ NIHMS277085; NLM/ PMC3065926
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95. Zhang YW, Greenblatt DY, Repplinger D, Bargren A, Adler JT, Sippel RS, Chen H: Older age and larger tumor size predict malignancy in hürthle cell neoplasms of the thyroid. Ann Surg Oncol; 2008 Oct;15(10):2842-6
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  • [Title] Older age and larger tumor size predict malignancy in hürthle cell neoplasms of the thyroid.
  • BACKGROUND: Hürthle cell neoplasms (HCNs) are rare tumors of the thyroid gland.
  • The definitive treatment for Hürthle cell carcinoma (HCC) is total thyroidectomy, while thyroid lobectomy is adequate for Hürthle cell adenoma (HCA).
  • However, differentiating HCC from HCA either before or during surgery is a challenge.
  • Medical records of 55 consecutive patients who underwent thyroid resections for the preoperative diagnosis of HCN were reviewed.
  • RESULTS: Of the 55 patients with HCN, 46 (84%) had adenomas and 9 (16%) had carcinomas.
  • Patients with HCC were significantly older than those with HCA (66 +/- 6 years versus 53 +/- 2 years, P = 0.01).
  • All HCNs less than 2 cm in diameter were benign.
  • One patient with HCC had recurrence of the disease, but there were no disease-related deaths.
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasm Recurrence, Local / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18665423.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T35 DK062709
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS778770; NLM/ PMC4852735
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96. Malagon I, Onkenhout W, Klok M, van der Poel PF, Bovill JG, Hazekamp MG: Gut permeability in neonates after a stage 1 Norwood procedure. Pediatr Crit Care Med; 2005 Sep;6(5):547-9
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  • Mesenteric perfusion is challenged preoperatively due to an imbalance between the systemic and pulmonary circulations and challenged intraoperatively due to hypothermic circulatory arrest.
  • DESIGN: Seven patients with hypoplastic left heart syndrome: clinical presentation, gut permeability findings, and outcome.
  • CONCLUSIONS: Gut permeability as assessed by the dual sugar permeability test is abnormal in patients with hypoplastic left heart syndrome before and after surgery.
  • This may be a sign of a low output state and may help to identify patients at risk of developing necrotizing enterocolitis.
  • [MeSH-major] Cardiopulmonary Bypass. Heart Arrest, Induced. Hypoplastic Left Heart Syndrome / surgery. Intestinal Absorption / physiology

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  • [CommentIn] Pediatr Crit Care Med. 2005 Sep;6(5):614-5 [16148833.001]
  • (PMID = 16148815.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gastrointestinal Agents; 4618-18-2 / Lactulose; QN34XC755A / Rhamnose
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97. Etz CD, Zoli S, Kari FA, Mueller CS, Bodian CA, Di Luozzo G, Plestis KA, Griepp RB: Redo lateral thoracotomy for reoperative descending and thoracoabdominal aortic repair: a consecutive series of 60 patients. Ann Thorac Surg; 2009 Sep;88(3):758-66; discussion 767
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  • Forty-one patients were hypertensive (68%), 18 were smokers (30%), 9 had Marfan syndrome (15%), 9 had coronary artery disease (15%), 5 had chronic obstructive pulmonary disease (8%), and 3 had diabetes mellitus (5%).
  • Adverse outcome occurred in 3 of 4 patients who had clamp-and-sew technique, 6 of 21 using partial cardiopulmonary bypass (28.6%), and 3 of 17 with partial left heart bypass (17.7%), but only 1 of 18 with hypothermic circulatory arrest (5.6%).
  • CONCLUSIONS: Reoperative DTA/TAAA repair was significantly safer with hypothermic circulatory arrest rather than partial cardiopulmonary bypass, partial left heart bypass, or clamp-and-sew strategy.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Aortic Coarctation / surgery. Aortic Diseases / surgery. Atherosclerosis / surgery. Cardiopulmonary Bypass. Circulatory Arrest, Deep Hypothermia Induced. Evoked Potentials, Motor / physiology. Evoked Potentials, Somatosensory / physiology. Female. Heart Bypass, Left. Hospital Mortality. Humans. Kaplan-Meier Estimate. Male. Marfan Syndrome / surgery. Middle Aged. Neurologic Examination. Reoperation / methods. Survival Rate. Young Adult

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  • (PMID = 19699894.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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98. Lee KH, Lee BM: Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A; 2007 Mar 1;70(5):388-92
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  • [Title] Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia.
  • (-)-Hydroxycitric acid (HCA) is widely used as an ingredient for nutritional supplements aimed at reducing food intake, appetite, and body weight.
  • In this study, the genotoxicity of HCA was evaluated using three tests: a bacterial reverse mutation assay (Ames test), an in vitro chromosomal aberration (CA) test, and an in vivo micronucleus (MN) test.
  • HCA was negative by the Ames test in the presence or absence of a microsomal metabolizing system.
  • HCA did not induce mutagenic activity in the Ames test, and no significant mutagenic potency was indicated by CA tests.
  • However, HCA significantly and dose-dependently increased the number of MNPCEs (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) and PCE/(PCE + NCE) ratios according to the MN test.
  • These results suggest that HCA preferentially induce micronuclei.
  • [MeSH-minor] Animals. Cell Line. Chromosome Aberrations / chemically induced. Cricetinae. Cricetulus. Garcinia cambogia. Mice. Mutagenicity Tests

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  • [CommentIn] J Toxicol Environ Health A. 2008;71(5):348-9; author reply 350-1 [18214809.001]
  • (PMID = 17454564.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Citrates; 8W94T9026R / hydroxycitric acid
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99. Moench C, Burck I, Bug R, Bak YJ, Richter B, Schroeder R, Klarner A, Strey CW, Vogl T, Bechstein W: [Hepatic angiomyolipoma--a rare liver tumor]. Z Gastroenterol; 2008 Jan;46(1):54-7
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  • [Title] [Hepatic angiomyolipoma--a rare liver tumor].
  • A 22-year-old woman was treated for a hepatic lesion with a high suspicion of a liver adenoma at another hospital.
  • A biopsy of the liver lesion revealed hepatic adenoma.
  • On MRI scan, the liver mass measured 10 x 9 x 9 cm in the right liver lobe with contact to the right hilum.
  • Because of the histological signs of adenoma a right hepatic lobectomy was performed.
  • The pathological diagnosis of hepatic angiomyolipoma was obtained.
  • Angiomyolipoma of the liver is a rare benign mesenchymal tumour often mimicking other hepatic lesions.
  • The biological behaviour of the tumour is benign, although distant metastases are occasionally possible.
  • [MeSH-major] Angiomyolipoma. Liver Neoplasms
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Hepatectomy. Humans. Liver / pathology. Magnetic Resonance Imaging

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  • (PMID = 18188817.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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100. Kulik A, Allen BT, Kouchoukos NT: Incidence and management of intercostal patch aneurysms after repair of thoracoabdominal aortic aneurysms. J Thorac Cardiovasc Surg; 2009 Aug;138(2):352-8
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  • METHODS: From January 1986 to July 2008, 38 patients with descending thoracic aortic aneurysms and 117 patients with thoracoabdominal aortic aneurysms underwent surgical repair with cardiopulmonary bypass, hypothermic circulatory arrest, and intercostal artery reimplantation as a Carrel patch.

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  • (PMID = 19619778.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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