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1. Nazarko L: 'Nurses must lead the discussion on HCA roles'. Nurs Times; 2008 Apr 8-14;104(14):10
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  • [Title] 'Nurses must lead the discussion on HCA roles'.

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  • (PMID = 18497231.001).
  • [ISSN] 0954-7762
  • [Journal-full-title] Nursing times
  • [ISO-abbreviation] Nurs Times
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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2. Pereira FM, Bueno MI: Image evaluation with chemometric strategies for quality control of paints. Anal Chim Acta; 2007 Apr 11;588(2):184-91
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  • The images were converted in gray color scale histograms, the resulting data were organized into a matrix form and analyzed with the help of principal component analysis (PCA) and hierarchical cluster analysis (HCA).

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  • (PMID = 17386809.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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3. Zhao LH, Wu MH, Xiang BR: Analysis of Psoralea corylifolia L. fruits in different regions. Chem Pharm Bull (Tokyo); 2005 Aug;53(8):1054-7
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  • [Title] Analysis of Psoralea corylifolia L. fruits in different regions.
  • Application of multivariate data analysis has become a popular method in the last decades, mainly because it can provide information not otherwise accessible.
  • The information includes classification, searching similarities, finding relationships, finding physical significance to principal components, etc.
  • The results were studied by hierarchical cluster analysis (HCA) and principal components analysis (PCA).
  • [MeSH-minor] Chromatography, High Pressure Liquid. Cluster Analysis. Multivariate Analysis

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  • (PMID = 16079549.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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4. Skalický T, Treska V, Sutnar A, Liska V, Molácek J, Mírka H, Ferda J, Ohlídalová K, Slauf F, Novák M: [Surgical treatment of benign liver tumours--indications and results]. Zentralbl Chir; 2009 Apr;134(2):141-4
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  • [Title] [Surgical treatment of benign liver tumours--indications and results].
  • [Transliterated title] Wann sollte man benigne Lebertumoren chirurgisch behandeln?*
  • The authors present their results on the treatment of benign liver tumors.
  • Benign liver lesions were rather rare compared to malignant tumours, for which 273 patients were treated within the same period.
  • The most often found benign -lesions were hepatocellular adenoma, focal nodular hyperplasia (FNH) and hemangioma.
  • Sometimes, it was not possible to make a correct diagnosis preoperatively.
  • The surgical procedures used for benign tumours were mostly enucleation and non-anatomic parenchyma-saving resection (55.4 %).
  • [MeSH-major] Adenoma, Liver Cell / surgery. Focal Nodular Hyperplasia / surgery. Hemangioma / surgery. Hepatectomy / methods. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cystadenoma / diagnosis. Cystadenoma / surgery. Diagnosis, Differential. Diagnostic Imaging. Female. Hamartoma / diagnosis. Hamartoma / surgery. Humans. Lymphangioma / diagnosis. Lymphangioma / surgery. Male. Middle Aged. Young Adult

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  • (PMID = 19382044.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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5. Herbst U, Fuchs JI, Teubner W, Steinberg P: Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Toxicol Appl Pharmacol; 2006 Apr 15;212(2):136-45
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  • [Title] Malignant transformation of human colon epithelial cells by benzo[c]phenanthrene dihydrodiolepoxides as well as 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
  • Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) ingested with food have repeatedly been suggested to be involved in the malignant transformation of colon epithelial cells.
  • In order to test this hypothesis, HCEC cells (SV40 large T antigen-immortalized human colon epithelial cells) were incubated with a racemic mixture of benzo[c]phenanthrene dihydrodiol epoxides (B[c]PhDE), extremely potent carcinogenic PAH metabolites in vivo, or with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP), the N-hydroxylated metabolite of the most abundant HCA in cooked meat.
  • First, it was shown that HCEC cells express sulfotransferase 1A1, which is needed to metabolize N-OH-PhIP to the corresponding N-sulfonyloxy derivative, the direct precursor molecule of genotoxic nitrenium ions.
  • Thereafter, exponentially growing HCEC cells were exposed five times to 0.1 microg (0.37 nmol) B[c]PhDE/ml for 30 min or 0.72 microg (3 nmol) N-OH-PhIP/ml for 24 h.
  • Chemically treated HCEC cells showed an enhanced saturation density and grew faster than the corresponding solvent-treated cell cultures.
  • After five treatment cycles, HCEC(B[c]PhDE) as well as HCEC(N-OH-PhIP) cells lost cell-cell contact inhibition and started piling up and forming foci in the culture flasks.
  • Furthermore, HCEC(B[c]PhDE) and HCEC(N-OH-PhIP) cells were injected i.m. into SCID mice.
  • Within 6 weeks after injection, eight animals out of eight injected with HCEC(B[c]PhDE) or HCEC(N-OH-PhIP) cells developed tumors at the site of injection, thus demonstrating the high tumorigenic potential of the HCEC(B[c]PhDE) and HCEC(N-OH-PhIP) cell cultures.
  • Taken together, we show for the first time that the abovementioned active PAH metabolites as well as N-OH-PhIP are indeed able to malignantly transform human colon epithelial cells in vitro.
  • [MeSH-major] Carcinogens / toxicity. Cell Transformation, Neoplastic / drug effects. Colon / cytology. Epithelial Cells / physiology. Epoxy Compounds / toxicity. Imidazoles / toxicity. Phenanthrenes / toxicity. Pyridines / toxicity
  • [MeSH-minor] Animals. Blotting, Western. Cell Proliferation / drug effects. Dimethyl Sulfoxide / pharmacology. Humans. Immunohistochemistry. Mice. Mice, SCID

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  • (PMID = 16137733.001).
  • [ISSN] 0041-008X
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Epoxy Compounds; 0 / Imidazoles; 0 / Phenanthrenes; 0 / Pyridines; 124489-20-9 / 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; YOW8V9698H / Dimethyl Sulfoxide
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6. van Dekken H, Verhoef C, Wink J, van Marion R, Vissers KJ, Hop WC, de Man RA, IJzermans JN, van Eijck CH, Zondervan PE: Cell biological evaluation of liver cell carcinoma, dysplasia and adenoma by tissue micro-array analysis. Acta Histochem; 2005;107(3):161-71
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  • [Title] Cell biological evaluation of liver cell carcinoma, dysplasia and adenoma by tissue micro-array analysis.
  • The clinical and morphological definition of hepatocellular carcinoma (HCC), dysplasia and adenoma suffers from a lack of biological understanding.
  • This is especially important in the histomorphological diagnosis of nodular liver lesions in needle biopsies.
  • Therefore, we constructed a liver tissue micro-array (TMA) and evaluated 48 HCCs, 46 dysplasias, 8 adenomas, 20 cirrhotic specimens and 28 normal liver samples derived from 68 patients.
  • An abnormal chromosome 1 number, i.e. the percentage of hyperdiploid cells, was 11.0, 13.7, 16.1, 23.7 and 31.3 for normal liver samples, adenomas, cirrhosis, dysplasias and HCCs, respectively.
  • A significant difference was found for HCC versus cirrhosis (P = 0.024) or adenoma (P = 0.033), a trend (borderline significance) was seen for dysplasia versus cirrhosis (P = 0.094).
  • Proliferation was also higher in HCC than in adenoma (P = 0.025), whereas a trend (borderline significance) was observed for Rb1 overexpression (P = 0.063).
  • These data suggest that in the liver cell dysplasia-carcinoma pathway, changes in ploidy are followed by increased proliferation and cell biological perturbations involving p53 and Rb1.
  • Adenomas can be distinguished from carcinomas, but not from dysplasias, based on ploidy and proliferation characteristics.
  • [MeSH-major] Adenoma, Liver Cell / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Hepatocellular / metabolism. Liver Neoplasms / metabolism. Precancerous Conditions / metabolism. Protein Array Analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Proliferation. Chromosome Aberrations. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Liver Cirrhosis / genetics. Liver Cirrhosis / metabolism. Liver Cirrhosis / pathology. Male. Middle Aged. Ploidies


7. Catasus L, D'Angelo E, Pons C, Espinosa I, Prat J: Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations. Mod Pathol; 2010 May;23(5):694-702
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  • Expression profiling of 22 genes involved in PI3K-AKT signaling pathway was analyzed in 38 endometrial carcinomas using TaqMan low-density array (TLDA) analysis.
  • The gene expression pattern was analyzed by hierarchical clustering analysis.
  • Unsupervised clustering divided the high-grade endometrial carcinomas into two clusters.
  • Almost all non-endometrioid adenocarcinomas (serous and clear cell adenocarcinomas) were segregated into this cluster.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cluster Analysis. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Signal Transduction / genetics. Tissue Array Analysis. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20173732.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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8. Delmo Walter EM, Hübler M, Alexi-Meskishvili V, Miera O, Weng Y, Loforte A, Berger F, Hetzer R: Staged surgical palliation in hypoplastic left heart syndrome and its variants. J Card Surg; 2009 Jul-Aug;24(4):383-91
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  • [Title] Staged surgical palliation in hypoplastic left heart syndrome and its variants.
  • BACKGROUND: Surgical options for infants with hypoplastic left heart syndrome (HLHS) and/or its variants are cardiac transplantation or the heart-preserving staged palliation with Norwood operation,followed by a two-staged Fontan procedure.
  • The causes of mortality were sepsis, capillary leak,or heart failure.
  • One patient underwent heart transplantation after the second stage because of heart failure.
  • Among 34 Norwood survivors, four are slightly tachypneic from a mild pulmonary hyperperfusion; one presents symptoms of minimal brain disease.
  • Lower operative weight, ascending aortic size, prolonged duration of cardiopulmonary bypass, and hypothermic circulatory arrest were identified to significantly influence early mortality after the Norwood procedure.
  • [MeSH-major] Cardiovascular Surgical Procedures / methods. Hypoplastic Left Heart Syndrome / mortality. Hypoplastic Left Heart Syndrome / surgery. Outcome Assessment (Health Care). Palliative Care
  • [MeSH-minor] Abnormalities, Multiple. Aorta / pathology. Arrhythmias, Cardiac / mortality. Body Weight. Cardiopulmonary Bypass / statistics & numerical data. Circulatory Arrest, Deep Hypothermia Induced. Female. Follow-Up Studies. Heart Failure / mortality. Humans. Infant. Infant, Newborn. Male. Multivariate Analysis. Retrospective Studies. Risk Factors. Sepsis / mortality. Time Factors

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  • (PMID = 19040407.001).
  • [ISSN] 1540-8191
  • [Journal-full-title] Journal of cardiac surgery
  • [ISO-abbreviation] J Card Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Wang D, Lagerstrom R, Sun C, Bishof L, Valotton P, Götte M: HCA-vision: Automated neurite outgrowth analysis. J Biomol Screen; 2010 Oct;15(9):1165-70
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  • [Title] HCA-vision: Automated neurite outgrowth analysis.
  • Automating the analysis of neurons in culture represents a key aspect of the search for neuroactive compounds.
  • A number of commercial neurite analysis software packages tend to measure some basic features such as total neurite length and number of branching points.
  • The authors have developed a suite of image analysis tools that will allow researchers to produce quality analyses at primary screening rates.
  • In mixed cell populations, neurons can be filtered and separated from other brain cell types so that neurite analysis can be performed only on neurons.
  • It supports batch processing with a built-in database to store the batch-processing results, a batch result viewer, and an ad hoc query builder for users to retrieve features of interest.
  • The suite of tools has been deployed into a software package called HCA-Vision.
  • The free version of the software package is available at http://www.hca-vision.com.

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  • (PMID = 20855562.001).
  • [ISSN] 1552-454X
  • [Journal-full-title] Journal of biomolecular screening
  • [ISO-abbreviation] J Biomol Screen
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor
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10. ACHE Gold Medal Award. A high-flying career. HCA's Bovender feted for his outside contributions. Mod Healthc; 2007 Jan 29;37(5):28
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  • [Title] ACHE Gold Medal Award. A high-flying career. HCA's Bovender feted for his outside contributions.

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  • (PMID = 17319005.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Bovender J
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11. Evans CT, Hershow RC, Chin A, Foulis PR, Burns SP, Weaver FM: Bloodstream infections and setting of onset in persons with spinal cord injury and disorder. Spinal Cord; 2009 Aug;47(8):610-5
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  • [Title] Bloodstream infections and setting of onset in persons with spinal cord injury and disorder.
  • OBJECTIVE: Health-care-associated (HCA) bloodstream infection (BSI) has been shown to be a distinct epidemiologic category in the general adult population, but few studies have examined specific patient populations.
  • The objective of this study was to assess characteristics associated with BSI that occurred in the hospital (hospital-acquired, HA BSI), from health-care contact outside the hospital (HCA BSI) or in the community (community-acquired, CA BSI) in veterans with spinal cord injury and disorder (SCI&D).
  • RESULTS: Four hundred and thirteen episodes of BSI occurred in 226 patients, with a rate of 7.2 BSI episodes per 100 admissions: 267 (64.7%) were HA BSI, 110 (26.6%) were HCA BSI and 36 (8.7%) were CA BSI.
  • Antibiotic resistance was more common in those with HA BSI (65.5%) compared with that in those with HCA (49.1%, P=0.001) and CA BSI (22.2%, P<0.0001).
  • Methicillin resistance in Staphylococcus aureus was highly prevalent; HA BSI (84.5%), HCA BSI (60.6%) and CA BSI (33.3%).
  • CONCLUSION: HCA BSI comprises one-quarter of all BSIs in hospitalized patients with SCI&D.
  • Although those with HCA and CA BSI share similarities, several differences in medical characteristics and causal microorganism are noted.
  • Treatment and management strategies for HCA and CA infections need to vary.

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  • (PMID = 19238165.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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12. Holst RM, Laurini R, Jacobsson B, Samuelsson E, Sävman K, Doverhag C, Wennerholm UB, Hagberg H: Expression of cytokines and chemokines in cervical and amniotic fluid: relationship to histological chorioamnionitis. J Matern Fetal Neonatal Med; 2007 Dec;20(12):885-93
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  • OBJECTIVE: To correlate cervical and amniotic fluid cytokines and macrophage-related chemokines to the development of histological chorioamnionitis (HCA) in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PPROM).
  • STUDY DESIGN: Cervical and amniotic fluid interleukin (IL)-6, IL-8, IL-18, monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 from pregnant women (at <or=34 weeks of gestation) in PTL (N = 42) were analyzed and related to the subsequent occurrence of HCA or inflammatory signs in the placenta.
  • RESULTS: Intra-amniotic levels of IL-6, IL-8, IL-18, MCP-1, and MCP-3 were significantly higher in PTL cases with HCA compared to non-HCA controls, whereas no such relationship was obtained in the PPROM group.
  • Cervical IL-8 and IL-6 (but not IL-18, MCP-1, MCP-2, and MCP-3) in PTL patients was associated with HCA, and at a cut-off level of 10.0 ng/mL cervical IL-8 was a strong predictor of HCA in the PTL cases (sensitivity 100%, specificity 67%, positive predictive value 63%, negative predictive value 100%).
  • The cytokine and chemokine levels in the group with inflammatory signs were generally higher than in controls but lower compared to the concentrations in the HCA group.
  • CONCLUSIONS: The amniotic levels of IL-6, IL-8, IL-18, and the CC-chemokines MCP-1 and MCP-3 in PTL patients all predicted HCA, whereas only IL-8 was a clinically useful marker of HCA in the cervical fluid.

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  • (PMID = 18050018.001).
  • [ISSN] 1476-7058
  • [Journal-full-title] The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [ISO-abbreviation] J. Matern. Fetal. Neonatal. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chemokine CCL2; 0 / Chemokines; 0 / Cytokines; 0 / Interleukins
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13. Hancock H, Campbell S, Ramprogus V, Kilgour J: Role development in health care assistants: the impact of education on practice. J Eval Clin Pract; 2005 Oct;11(5):489-98
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  • In nursing this has resulted in the delegation of 'nursing care' to health care assistants (HCAs).
  • This study sought to evaluate the impact of a HCA Development Programme on care delivery.
  • Secondly, it sought to understand the preparedness of HCAs to undertake the programme and the new roles set for them.
  • Semi-structured interviews were conducted with four HCAs, eight of each of their colleagues and four patients.
  • For part two, 12 HCAs were interviewed.
  • Data were analysed following the principles of thematic analysis.
  • FINDINGS: The findings for part one showed positive changes to the HCAs' role, which included skill and knowledge development, increased confidence and initiative and a more holistic approach to care.
  • The HCAs in part two voiced positive and negative views of their role development.
  • Of the 12 HCAs interviewed, eight were prepared to attend the programme, two were undecided, and two were reluctant to attend.
  • CONCLUSIONS: The findings indicated that while the HCA Development Programme positively influenced the role of the HCA, there was a need to invest more into preparation for the restructuring of roles.

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  • (PMID = 16164591.001).
  • [ISSN] 1356-1294
  • [Journal-full-title] Journal of evaluation in clinical practice
  • [ISO-abbreviation] J Eval Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Henriksen U, Fog J, Loechel F, Praestegaard M: Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays. Comb Chem High Throughput Screen; 2008 Aug;11(7):537-44
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  • [Title] Profiling of multiple signal pathway activities by multiplexing antibody and GFP-based translocation assays.
  • Multiplexing of GFP based and immunofluorescence translocation assays enables easy acquisition of multiple readouts from the same cell in a single assay run.
  • Immunofluorescence assays monitor translocation, phosphorylation, and up/down regulation of endogenous proteins.
  • GFP-based assays monitor translocation of stably expressed GFP-fusion proteins.
  • Such assays may be multiplexed along (vertical), across (horizontal), and between (branch) signal pathways.
  • 1) The MK2-GFP assay monitors translocation of MK2-GFP from the nucleus to the cytoplasm in response to stimulation of the p38 pathway.
  • By applying different immunofluorescent assays to the MK2 assay, a multiplexed HCA system is created for deconvolution of p38 pathway activation including assay readouts for MK2, p38, NFkappaB, and c-Jun.
  • 2) A method for evaluating GPCR activation and internalization in a single assay run has been established by multiplexing GFP-based internalization assays with immunofluorescence assays for downstream transducers of GPCR activity: pCREB (cAMP sensor), NFATc1 (Ca(2+) sensor), and ERK (G-protein activation).
  • 3) Cell toxicity readouts can be linked to primary readouts of interest via acquisition of secondary parameters describing cellular morphology.
  • The ATF6 Redistribution assay is provided as an example.
  • These multiplex strategies provide a unique opportunity to enhance HCA data quality and save time during drug discovery.
  • From a single assay run, several assay readouts are obtained that help the user to deconvolute the mode of action of test compounds.
  • [MeSH-major] Antibodies / analysis. Green Fluorescent Proteins / analysis. Signal Transduction

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  • (PMID = 18694390.001).
  • [ISSN] 1386-2073
  • [Journal-full-title] Combinatorial chemistry & high throughput screening
  • [ISO-abbreviation] Comb. Chem. High Throughput Screen.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.- / Phosphotransferases
  • [Number-of-references] 23
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15. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CAS No. 123-35-3) in F344/N rats and B6C3F1 mice (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Dec;(557):1-163
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  • Except for lesion incidence data in groups administered 2 g/kg or less, data from rats that died early were excluded from the analysis and summary tables.
  • Right kidney and liver weights of dosed males and females were generally significantly greater than those of the vehicle controls.
  • The right kidney weights of 1 g/kg females and the liver weights of females administered 0.5 or 1 g/kg were significantly increased.
  • In the standard evaluation of the kidney, the incidence of renal tubule adenoma was significantly increased in 0.5 g/kg male rats, and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in 0.25 and 0.5 g/kg males.
  • In both the extended evaluation and the combined standard and extended evaluations, the incidences of renal tubule adenoma and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in the 0.25 and 0.5 g/kg groups of males.
  • The incidences of liver neoplasms were significantly increased in 0.25 and/or 0.5 g/kg males and 0.25 g/kg females.
  • Liver neoplasms included hepatocellular adenoma and hepatocellular carcinoma in males and females and hepatoblastoma in males.
  • The incidences of hepatocellular hypertrophy were significantly increased in 0.5 g/kg males and females, as was the incidence of mixed cell focus in 0.5 g/kg females.
  • GENETIC TOXICOLOGY: beta-myrcene did not show evidence of genotoxicity in assays conducted by the NTP.
  • No mutagenicity was observed in any of several strains of Salmonella typhimurium or Escherichia coli in two independent Ames assays conducted with and without exogenous metabolic activation.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female F344/N rats based on increased incidences of renal tubule adenoma.
  • There was clear evidence of carcinogenic activity of beta-myrcene in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma and carcinoma.
  • Administration of beta-myrcene induced nonneoplastic lesions in the kidney of male and female rats, nose of male rats, and liver of male and female mice.
  • [MeSH-major] Adenoma / chemically induced. Carcinoma, Hepatocellular / chemically induced. Hepatoblastoma / chemically induced. Kidney Neoplasms / chemically induced. Liver Neoplasms / chemically induced. Monoterpenes / toxicity. Neoplasms, Experimental / chemically induced

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  • (PMID = 21415873.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Monoterpenes; 123-35-3 / beta-myrcene
  • [Investigator] Chan PC; Cesta MF; Sills RC; Bishop JB; Bristol DW; Bucher JR; Chhabra RS; Foster PM; Herbert RA; Hooth MJ; King-Herbert AP; Kissling GE; Malarkey DE; Roycroft JH; Sanders JM; Smith CS; Travlos GS; Walker NJ; Witt KL
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16. Seyama Y, Sano K, Tang W, Kokudo N, Sakamoto Y, Imamura H, Makuuchi M: Simultaneous resection of liver cell adenomas and an intrahepatic portosystemic venous shunt with elevation of serum PIVKA-II level. J Gastroenterol; 2006 Sep;41(9):909-12
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  • [Title] Simultaneous resection of liver cell adenomas and an intrahepatic portosystemic venous shunt with elevation of serum PIVKA-II level.
  • A 27-year-old woman with no history of liver disease or oral contraceptive use presented with sudden abdominal pain.
  • Laboratory data showed mild liver dysfunction with jaundice.
  • Computed tomography and angiography revealed centrally located large liver cell adenomas (LCAs) and an intrahepatic portosystemic venous shunt (IHPSS) in the left lobe.
  • Under the diagnosis of LCAs and IHPSS, the patient underwent simultaneous resection of the four liver tumors and portovenous shunt, and the hepatic vascular abnormality was resolved.
  • The pathological diagnosis was LCAs without hepatocellular carcinoma.
  • Immunohistochemical analysis with an anti-PIVKA-II monoclonal antibody showed positive staining of the adenoma cells.
  • [MeSH-major] Adenoma, Liver Cell. Arteriovenous Fistula. Biomarkers / blood. Hepatectomy / methods. Hepatic Veins / abnormalities. Liver Neoplasms. Portal Vein / abnormalities. Protein Precursors / blood

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  • [Cites] World J Gastroenterol. 2003 Oct;9(10):2379-81 [14562419.001]
  • [Cites] J Gastroenterol. 1996 Jun;31(3):441-5 [8726839.001]
  • [Cites] Ann Surg. 2000 Jan;231(1):74-81 [10636105.001]
  • [Cites] Int J Oncol. 2003 May;22(5):969-75 [12684661.001]
  • [Cites] Clin Radiol. 1986 Sep;37(5):513-4 [3757427.001]
  • [Cites] Radiology. 2000 Aug;216(2):395-402 [10924560.001]
  • [Cites] Abdom Imaging. 1994 Sep-Oct;19(5):438-40 [7950822.001]
  • [Cites] AJR Am J Roentgenol. 1990 Sep;155(3):527-8 [2117349.001]
  • [Cites] Arch Surg. 1993 Mar;128(3):349-52 [8442695.001]
  • (PMID = 17048056.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Protein Precursors; 53230-14-1 / acarboxyprothrombin; 9001-26-7 / Prothrombin
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17. Lee KH, Lee BM: Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A; 2007 Mar 1;70(5):388-92
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  • [Title] Evaluation of the genotoxicity of (-)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia.
  • (-)-Hydroxycitric acid (HCA) is widely used as an ingredient for nutritional supplements aimed at reducing food intake, appetite, and body weight.
  • In this study, the genotoxicity of HCA was evaluated using three tests: a bacterial reverse mutation assay (Ames test), an in vitro chromosomal aberration (CA) test, and an in vivo micronucleus (MN) test.
  • HCA was negative by the Ames test in the presence or absence of a microsomal metabolizing system.
  • HCA did not induce mutagenic activity in the Ames test, and no significant mutagenic potency was indicated by CA tests.
  • However, HCA significantly and dose-dependently increased the number of MNPCEs (micronucleated polychromatic erythrocytes/1000 polychromatic erythrocytes) and PCE/(PCE + NCE) ratios according to the MN test.
  • These results suggest that HCA preferentially induce micronuclei.
  • [MeSH-minor] Animals. Cell Line. Chromosome Aberrations / chemically induced. Cricetinae. Cricetulus. Garcinia cambogia. Mice. Mutagenicity Tests

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  • [CommentIn] J Toxicol Environ Health A. 2008;71(5):348-9; author reply 350-1 [18214809.001]
  • (PMID = 17454564.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Citrates; 8W94T9026R / hydroxycitric acid
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18. Lim SH, Feng L, Kemling JW, Musto CJ, Suslick KS: An optoelectronic nose for the detection of toxic gases. Nat Chem; 2009 Oct;1(7):562-7
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  • The sensor consists of a disposable array of cross-responsive nanoporous pigments with colours that are changed by diverse chemical interactions with analytes.
  • Different TICs were identified readily using a standard chemometric approach (hierarchical clustering analysis), with no misclassifications over 140 trials.

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  • [Cites] Nature. 2000 Aug 17;406(6797):710-3 [10963592.001]
  • [Cites] Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3035-9 [12610211.001]
  • [Cites] Nat Mater. 2003 Jan;2(1):19-24 [12652667.001]
  • [Cites] Acc Chem Res. 2004 Sep;37(9):663-72 [15379582.001]
  • [Cites] MRS Bull. 2004 Oct;29(10):720-5 [15991401.001]
  • [Cites] Angew Chem Int Ed Engl. 2005 Jul 18;44(29):4528-32 [16003792.001]
  • [Cites] J Am Chem Soc. 2005 Aug 24;127(33):11548-9 [16104700.001]
  • [Cites] Anal Chem. 2006 Jun 1;78(11):3591-600 [16737212.001]
  • [Cites] J Agric Food Chem. 2006 Jul 12;54(14):4925-31 [16819897.001]
  • [Cites] J Agric Food Chem. 2007 Jan 24;55(2):237-42 [17227048.001]
  • [Cites] J Org Chem. 2007 Feb 2;72(3):687-99 [17253783.001]
  • [Cites] Biol Rev Camb Philos Soc. 2007 Aug;82(3):455-79 [17624963.001]
  • [Cites] Org Lett. 2008 Oct 16;10(20):4405-8 [18783231.001]
  • [Cites] Langmuir. 2008 Nov 18;24(22):13168-72 [18950204.001]
  • [Cites] Anal Chem. 2009 Aug 1;81(15):6526-33 [20337402.001]
  • (PMID = 20160982.001).
  • [ISSN] 1755-4349
  • [Journal-full-title] Nature chemistry
  • [ISO-abbreviation] Nat Chem
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES016011-03; United States / NIEHS NIH HHS / ES / U01 ES016011; United States / NIEHS NIH HHS / ES / U01 ES016011-03; United States / NIEHS NIH HHS / ES / U01ES016011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gases
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19. Kacerovský M, Drahosová M, Hornychová H, Plísková L, Bolehovská R, Förstl M, Tosner J, Lesko D, Andrýs C: [Amniotic fluid interleukin 6 levels in preterm premature rupture of membranes]. Ceska Gynekol; 2009 Dec;74(6):403-10
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  • OBJECTIVE: The purpose of this study was to determinate the changes of amniotic fluid interleukin 6 (IL-6) concentrations in patients with preterm premature rupture of the membranes (PPROM), and in the presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA).
  • The aim was to examine amniotic fluid IL-6 in relation to MIAC and HCA.
  • Twenty-eight of 37 patients placentas were collected and assessed for presence or absence HCA.
  • RESULTS: There was significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without MIAC and HCA (patients with MIAC and HCA: median 915 pg/ml, range 651-1854 pg/ml vs. patients without MIAC and HCA: median 780 pg/ml, range 184-1059 pg/ml; p=0.047).
  • There was no significant difference in the median amniotic fluid IL-6 concentration between patients with preterm rupture of the membranes with and without HCA (patients with HCA: median 829 pg/ml, range 195-1992 pg/ml vs. patients without HCA: median 768 pg/ml, range 184-1890 pg/ml; p = 0.31).
  • CONCLUSION: Amniotic fluid IL-6 concentrations patients with PPROM with presence HCA and MIAC were significantly higher than IL-6 concentration patients without HCA and MIAC.

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  • (PMID = 21246786.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Interleukin-6
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20. Renaud S, Hays AP, Brannagan TH 3rd, Sander HW, Edgar M, Weimer LH, Olarte MR, Dalakas MC, Xiang Z, Danon MJ, Latov N: Gene expression profiling in chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol; 2005 Feb;159(1-2):203-14
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  • Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups.
  • Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.
  • [MeSH-minor] Adult. Aged. Chronic Disease. Female. Humans. Male. Middle Aged. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction / genetics. Sural Nerve / pathology. Up-Regulation


21. Silva AR, Fragoso AC, Oliveira M, Costa-Maia J, Estevão-Costa, Bessa-Monteiro A, Campos M: [Laparoscopic excision of a hepatic mesothelial cyst]. Cir Pediatr; 2009 Oct;22(4):229-32
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  • [Title] [Laparoscopic excision of a hepatic mesothelial cyst].
  • [Transliterated title] Escisión laparoscópica de quiste mesotelial hepático.
  • Over the past few years there has been an increase in application of minimally invasive techniques in pediatric surgery, especially in the approach of liver lesions.
  • The authors present the clinical case of a three year old child, referred to our institution after an incidental finding of a liver cystic lesion in abdominal ultrasound.
  • The MRI confirmed the presence of the cystic lesion and pointed, as a possible etiology, a cystic cyst adenoma of the liver.
  • The anatomo-pathological and immunohistochemical studies concluded it was a mesotelial cyst of the liver.
  • The mesothelial cysts of the liver are very rare lesions, with difficult preoperative diagnosis.
  • [MeSH-major] Cysts / surgery. Hepatectomy / methods. Laparoscopy. Liver Diseases / surgery

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  • (PMID = 20405662.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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22. Puangsombat K, Smith JS: Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. J Food Sci; 2010 Mar;75(2):T40-7
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  • Heterocyclic amines (HCAs) are mutagenic compounds formed during cooking muscle foods at high temperature.
  • Inhibition of HCAs by rosemary extracts were evaluated with beef patties cooked at 191 degrees C (375 degrees F) for 6 min each side and 204 degrees C (400 degrees F) for 5 min each side.
  • The 5 extracts were directly added to beef patties at 3 levels (0.05%, 0.2%, and 0.5%) before cooking and HCA contents were extracted and quantified.
  • There was no statistical difference in the inhibition of HCAs in the 0.05%, 0.2%, and 0.5% rosemary extracts.
  • When cooking at 204 degrees C (400 degrees F) for 5 min each side, rosemary extracts 10E and 20E were superior to rosemary extracts 100W, 30E, and 40E in inhibiting HCA formation.
  • The inhibiting effect of rosemary extracts on HCA formation corresponded to their antioxidant activity based on a DPPH scavenging assay.
  • It is possible that these compounds might act synergistically in inhibiting the formation of HCAs.
  • [MeSH-major] Antioxidants / pharmacology. Heterocyclic Compounds, 2-Ring / analysis. Meat Products / analysis. Plant Extracts / pharmacology. Rosmarinus
  • [MeSH-minor] Animals. Cattle. Cooking / methods. Ethanol. Food Analysis / methods. Food Handling / methods. Gas Chromatography-Mass Spectrometry / methods. Imidazoles / analysis. Quinoxalines / analysis. Solid Phase Microextraction / methods. Time Factors. Water

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  • (PMID = 20492265.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Heterocyclic Compounds, 2-Ring; 0 / Imidazoles; 0 / Plant Extracts; 0 / Quinoxalines; 059QF0KO0R / Water; 3K9958V90M / Ethanol; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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23. Somasundar P, Boutros C, Helton WS, Espat NJ: Evaluation of a bipolar radiofrequency device for laparoscopic hepatic resection: technique and clinical experience in 18 patients. HPB (Oxford); 2009 Mar;11(2):145-9
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  • [Title] Evaluation of a bipolar radiofrequency device for laparoscopic hepatic resection: technique and clinical experience in 18 patients.
  • BACKGROUND: The increased frequency of laparoscopic hepatic resection as a principal or adjunct component of patient care has driven the need for and development of efficient and safe hepatic parenchymal transection technologies.
  • At present, various devices are available for pre-coagulation transection (PCT) of hepatic parenchyma with the intent of minimizing procedure-associated postoperative haemorrhage and bile leak.
  • This report presents the evaluation of a novel bipolar radiofrequency (RF) energy device for PCT used for laparoscopic hepatic resection.
  • METHODS: Patients undergoing laparoscopic hepatic resection using the Enseal device (SurgRx Inc.) were identified from the prospectively maintained hepatobiliary database.
  • RESULTS: A total of 18 patients, of whom 13 had malignant tumours (12 colorectal metastases and one hepatocellular carcinoma) and five had benign tumours (two hepatic adenomas and three haemangiomas) underwent 18 hepatic procedures, including two formal hemi-hepatectomies, four left lateral sections, three posterior sections and nine atypical non-anatomic resections.
  • Estimated blood loss did not differ from institutional historical control data; no postoperative haemorrhage, bile leaks or hepatic abscess or necrosis were identified (n = 18).

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  • [Cites] J Am Coll Surg. 2008 Jun;206(3):1122-8 [18501809.001]
  • [Cites] JSLS. 2008 Apr-Jun;12(2):213-6 [18435902.001]
  • [Cites] Arch Surg. 1994 Oct;129(10):1050-6 [7944934.001]
  • [Cites] Eur Surg Res. 2007;39(2):111-7 [17299268.001]
  • [Cites] Br J Surg. 2007 Mar;94(3):287-91 [17318804.001]
  • [Cites] Int Surg. 2007 Jan-Feb;92(1):20-6 [17390910.001]
  • (PMID = 19590639.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2697884
  • [Keywords] NOTNLM ; bipolar RFA / laparoscopy / liver resection
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24. Silva JP, Fonseca Ld, Baumgratz JF, Castro RM, Franchi SM, Lianza AC, Vila JH: Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach. Rev Bras Cir Cardiovasc; 2007 Apr-Jun;22(2):160-8
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  • [Title] Hypoplastic left heart syndrome: the report of a surgical strategy and comparative results of Norwood x Norwood-Sano approach.
  • OBJECTIVES: To report a surgical strategy for the Norwood procedure in the hypoplastic left heart syndrome (HLHS) that enables short hypothermic circulatory arrest time and aortic arch reconstruction with autologous pericardium patch.
  • Cannulation of the ductus arteriosus for systemic perfusion was the main part of the surgical strategy to reduce the hypothermic circulatory arrest time.
  • Hypothermic circulatory arrest times were 45.79+/-1.99 min and 36,8+/-1,52 min (p=0,0012), respectively.
  • CONCLUSIONS: This surgical strategy resulted in short circulatory arrest time, low mortality and low incidence of aortic coarctation.
  • [MeSH-major] Aortic Valve / surgery. Bioprosthesis. Heart Valve Prosthesis / standards. Hypoplastic Left Heart Syndrome / surgery. Pericardium / transplantation
  • [MeSH-minor] Anastomosis, Surgical. Brazil / epidemiology. Female. Heart Valve Prosthesis Implantation / mortality. Heart Ventricles / surgery. Humans. Infant, Newborn. Length of Stay. Male. Pulmonary Artery / surgery. Pulmonary Circulation. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17992320.001).
  • [Journal-full-title] Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular
  • [ISO-abbreviation] Rev Bras Cir Cardiovasc
  • [Language] eng; por
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Brazil
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25. Apostolakis E, Shuhaiber JH: Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery. Expert Rev Cardiovasc Ther; 2007 Nov;5(6):1147-61
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  • [Title] Antegrade or retrograde cerebral perfusion as an adjunct during hypothermic circulatory arrest for aortic arch surgery.
  • Three methods of cerebral protection have been applied between 1975 and today: hypothermic circulatory arrest as a basic method, either alone or with antegrade cerebral perfusion (ACP), or retrograde cerebral perfusion (RCP) as an adjunctive method.
  • ACP obtains a near-physiologic brain perfusion, with homogenous distribution of blood throughout the capillary beds, and extends the safe time of hypothermic circulatory arrest to 80 min, allowing the completion of whatever aortic arch work is necessary.

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  • (PMID = 18035930.001).
  • [ISSN] 1744-8344
  • [Journal-full-title] Expert review of cardiovascular therapy
  • [ISO-abbreviation] Expert Rev Cardiovasc Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 92
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26. Ge M, Zhao H, Wang W, Zhang Z, Yu X, Li W: Terahertz time-domain spectroscopy of four hydroxycinnamic acid derivatives. J Biol Phys; 2006 Nov;32(5):403-12
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  • The well-resolved absorption spectra of the hydroxycinnamic acid (HCA) derivatives, caffeic acid, ferulic acid, sinapic acid and chlorogenic acid, were measured over the frequency region from 0.3 to 2.0 THz at 294 K with terahertz time-domain spectroscopy (THz-TDS).
  • Theoretical calculation was applied to assist the analysis and assignment of the individual THz absorption spectra of the HCA derivatives with density functional theory (DFT).
  • The real and imaginary parts of dielectric function of the four HCA derivatives were also obtained.

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  • [Cites] J Phys Chem A. 2006 Feb 9;110(5):1951-9 [16451029.001]
  • [Cites] Free Radic Biol Med. 1998 Mar 1;24(4):594-606 [9559872.001]
  • [Cites] Biochim Biophys Acta. 1997 Jun 6;1335(3):335-42 [9202196.001]
  • [Cites] Free Radic Biol Med. 1996;20(7):933-56 [8743980.001]
  • [Cites] IUBMB Life. 1999 Jul;48(1):57-65 [10791916.001]
  • [Cites] Phys Med Biol. 2002 Nov 7;47(21):3807-14 [12452571.001]
  • [Cites] Biopolymers. 2002;67(4-5):310-3 [12012455.001]
  • [Cites] Lipids. 2000 Jun;35(6):633-8 [10901425.001]
  • [Cites] Biophys J. 2004 Mar;86(3):1649-54 [14990492.001]
  • (PMID = 19669446.001).
  • [ISSN] 0092-0606
  • [Journal-full-title] Journal of biological physics
  • [ISO-abbreviation] J Biol Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2651536
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27. National Toxicology Program: Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Nov;(559):1-174
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  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • There were increases in hepatic cell proliferation in the 4,600 g/kg group at 14, 31, and 53 weeks.
  • Analysis of PCB 118 concentrations in dosed groups showed dose- and duration of dosing-dependent increases in fat, liver, lung, and blood.
  • The highest concentrations were seen in fat at 2 years with lower concentrations observed in the liver, lung, and blood.
  • At the 53-week interim evaluation, three 4,600 g/kg rats had liver cholangiocarcinoma and one had hepatocellular adenoma.
  • At 2 years, there were significant treatment-related increases in the incidences of cholangiocarcinoma and hepatocellular adenoma.
  • At 2 years, a significant dose-related increase in hepatic toxicity was observed and was characterized by increased incidences of numerous lesions including hepatocyte hypertrophy, inflammation, oval cell hyperplasia, pigmentation, multinucleated hepatocyte, eosinophilic and mixed cell foci, diffuse fatty change, toxic hepatopathy, nodular hyperplasia, necrosis, bile duct hyperplasia and cyst, and cholangiofibrosis.
  • A marginal increase in squamous cell carcinoma occurred in the 220 g/kg group.
  • At 2 years, there were marginally increased incidences of exocrine pancreatic adenoma or carcinoma in the 460, 1,000, and 4,600 g/kg core study groups.
  • Numerous nonneoplastic effects were seen in other organs including: adrenal cortical atrophy and cytoplasmic vacuolization, pancreatic acinar cell cytoplasmic vacuolization and arterial chronic active inflammation, follicular cell hypertrophy of the thyroid gland, inflammation and respiratory epithelial hyperplasia of the nose, and kidney pigmentation.
  • CONCLUSIONS: Under the conditions of this 2-year gavage study, there was clear evidence of carcinogenic activity of PCB 118 in female Harlan Sprague-Dawley rats based on increased incidences of neoplasms of the liver (cholangiocarcinoma, hepatocholangioma, and hepatocellular adenoma) and cystic keratinizing epithelioma of the lung.
  • Occurrences of squamous cell carcinoma of the uterus and acinar neoplasms of the pancreas may have been related to administration of PCB 118.
  • Administration of PCB 118 caused increased incidences of nonneoplastic lesions in the liver, lung, adrenal cortex, pancreas, thyroid gland, nose, and kidney.

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  • (PMID = 21383778.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 31508-00-6 / 2,3',4,4',5-pentachlorobiphenyl; DFC2HB4I0K / Polychlorinated Biphenyls; DO80M48B6O / Tetrachlorodibenzodioxin
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28. Flemming P, Lehmann U, Steinemann D, Kreipe H, Wilkens L: [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma]. Pathologe; 2006 Jul;27(4):238-43
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  • [Title] [Hepatocellular adenoma. Malignancy potential and differentiation from hepatocellular carcinoma].
  • [Transliterated title] Leberzelladenom. Entartungspotenzial und Abgrenzung vom hepatozellulären Karzinom.
  • In contrast to hepatocellular carcinoma (HCC), very few molecular pathological studies have been carried out on hepatocellular adenoma (HCA).
  • Particularly from the surgical point of view, based on views passed on verbally and in the literature of the 1970s and 1980s, a possible degeneration of the HCA provides grounds for operating.
  • Published cases of transitions from HCA into HCC were evaluated on the basis of today's morphological standards.
  • A comparison was made between the patterns of new molecular pathological studies of HCA, above all the work of our own groups, and those of HCC.
  • The results speak against the suggestion that a typical solitary HCA in pre-menopausal women is a precursor lesion of HCC.
  • After a critical review of the literature, only one casuistic case of a transition of HCA to HCC under a hormone therapy, which is no longer practiced today, remained.
  • A limitation of particular HCA in genetic and metabolic diseases, children, adult males, adenomatosis, and HCA-like tumors with known risk factors of HCC would seem pragmatically meaningful.
  • With classic HCA, however, the oncological indication for surgery does not apply.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Middle Aged

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  • [Cites] Arch Pathol Lab Med. 1981 Jun;105(6):296-9 [6263214.001]
  • [Cites] World J Gastroenterol. 2003 Oct;9(10):2379-81 [14562419.001]
  • [Cites] Hepatology. 2002 Oct;36(4 Pt 1):927-35 [12297840.001]
  • [Cites] Cancer Res. 1976 Jul;36(7 PT 2):2584-8 [179705.001]
  • [Cites] Gastroenterology. 2005 May;128(5):1211-8 [15887105.001]
  • [Cites] Mod Pathol. 2002 Mar;15(3):189-96 [11904335.001]
  • [Cites] Clin Cancer Res. 2005 May 15;11(10):3654-60 [15897561.001]
  • [Cites] Zentralbl Chir. 1998;123(2):140-4 [9556886.001]
  • [Cites] Ann Surg. 1988 Nov;208(5):558-64 [3190282.001]
  • [Cites] Eur J Contracept Reprod Health Care. 1998 Dec;3(4):194-200 [10036602.001]
  • [Cites] Genes Chromosomes Cancer. 2002 Oct;35(2):138-43 [12203777.001]
  • [Cites] J Hepatol. 2004 Jun;40(6):1036-9 [15158349.001]
  • [Cites] Cancer. 1991 Jul 15;68(2):341-7 [1712664.001]
  • [Cites] Mod Pathol. 2002 Apr;15(4):470-5 [11950923.001]
  • [Cites] Gastroenterology. 1997 Mar;112(3):919-22 [9041254.001]
  • [Cites] Hepatology. 1999 Jun;29(6):1858-62 [10347130.001]
  • [Cites] Radiology. 2000 Aug;216(2):395-402 [10924560.001]
  • [Cites] Pathologica. 2003 Apr;95(2):71-82 [12768875.001]
  • [Cites] Pathologe. 2001 May;22(3):184-90 [11402848.001]
  • [Cites] J Pathol. 2001 Apr;193(4):476-82 [11276006.001]
  • [Cites] J Mol Diagn. 2001 May;3(2):68-73 [11333302.001]
  • [Cites] Am J Surg Pathol. 1993 May;17(5):525-9 [8385884.001]
  • [Cites] Histopathology. 2006 Jun;48(7):876-8 [16722942.001]
  • [Cites] Am J Surg Pathol. 1993 Nov;17(11):1113-23 [8214256.001]
  • [Cites] Eur J Pediatr. 1993;152 Suppl 1:S63-70 [8391447.001]
  • [Cites] Hum Pathol. 2002 Aug;33(8):852-5 [12203220.001]
  • [Cites] Gut. 2002 Aug;51(2):253-8 [12117890.001]
  • [Cites] Rev Hosp Clin Fac Med Sao Paulo. 1994 Jan-Feb;49(1):30-3 [8029613.001]
  • [Cites] Expert Rev Mol Diagn. 2002 Mar;2(2):120-8 [11962332.001]
  • [Cites] Hepatology. 1993 Apr;17 (4):583-5 [7682980.001]
  • [Cites] Cancer. 1983 Oct 15;52(8):1510-5 [6311396.001]
  • [Cites] Ann Intern Med. 1986 Oct;105(4):547-9 [3019201.001]
  • [Cites] Arch Surg. 1994 Jul;129(7):712-7 [7517661.001]
  • [Cites] Arch Pathol Lab Med. 2004 Feb;128(2):222-6 [14736278.001]
  • [Cites] Arch Surg. 2001 Sep;136(9):1033-8 [11529826.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1309-14 [14745031.001]
  • [Cites] J Hepatol. 1996 Dec;25(6):976-9 [9007729.001]
  • [Cites] Histopathology. 1996 May;28(5):472-4 [8735726.001]
  • [Cites] Ann Intern Med. 1989 Mar 15;110(6):489-90 [2537593.001]
  • (PMID = 16736176.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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29. Scharitzer M, Schima W, Schober E, Reimer P, Helmberger TK, Holzknecht N, Stadler A, Ba-Ssalamah A, Weber M, Wrba F: Characterization of hepatocellular tumors: value of mangafodipir-enhanced magnetic resonance imaging. J Comput Assist Tomogr; 2005 Mar-Apr;29(2):181-90
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  • [Title] Characterization of hepatocellular tumors: value of mangafodipir-enhanced magnetic resonance imaging.
  • PURPOSE: To assess the value of mangafodipir trisodium-enhanced MR imaging for characterization of hepatocellular lesions.
  • MATERIALS AND METHODS: Magnetic resonance images of 41 patients with 48 histopathologically proven hepatocellular lesions (20 cases of focal nodular hyperplasia [FNH], 4 adenomas, 15 hepatocellular carcinomas [HCCs], 7 regenerative nodules, and 2 others) were retrospectively studied.
  • Qualitative analysis by 4 blinded independent readers included assessment of unenhanced images and, in a second step, assessment of unenhanced and contrast-enhanced images together.
  • Lesions were classified as benign or malignant using a 5-point scale, and readers made a specific diagnosis.
  • RESULTS: For characterization of hepatocellular lesions, mangafodipir-enhanced imaging was significantly superior to unenhanced imaging (P < 0.05).
  • On receiver operating characteristic analysis, the area under the curve was 0.768 (95% confidence interval: 0.633-0.903) for unenhanced images and 0.866 (95% confidence interval: 0.767-0.966) for evaluation of unenhanced and contrast-enhanced images together (P < 0.05).
  • Analysis of enhancement patterns aided in characterization and classification of tumors.
  • CONCLUSION: Administration of mangafodipir improves the differentiation between adenoma or HCC and "nonsurgical" lesions (FNH or regenerative nodules).
  • The accuracy for arriving at a specific diagnosis is higher when unenhanced and mangafodipir-enhanced images are considered together than for unenhanced MR images alone.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Contrast Media / administration & dosage. Edetic Acid / analogs & derivatives. Image Enhancement / methods. Image Processing, Computer-Assisted. Liver Neoplasms / diagnosis. Magnetic Resonance Imaging. Pyridoxal Phosphate / analogs & derivatives
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adenoma, Liver Cell / pathology. Adult. Aged. Biopsy. Diagnosis, Differential. Echo-Planar Imaging. Female. Focal Nodular Hyperplasia / diagnosis. Focal Nodular Hyperplasia / pathology. Humans. Infusions, Intravenous. Liver / pathology. Liver Cirrhosis / diagnosis. Liver Cirrhosis / pathology. Liver Regeneration / physiology. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 15772534.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 5V5IOJ8338 / Pyridoxal Phosphate; 9G34HU7RV0 / Edetic Acid; P28BIW0UTB / N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
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30. Duffin C: Healthcare assistants seen as more involved in patient care than nurses. Nurs Stand; 2006 Aug 16;20(49):5
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  • Patients have said that healthcare assistants (HCAs), not nurses, give most of the direct care they receive in hospital, research published in this week's Nursing Standard reveals.

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  • (PMID = 28086443.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Shum-Tim D, MacDonald D, Takayuki S, Laliberté E, Chen J, Jamal AM, Philip A, Platt R: Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest. Pediatr Crit Care Med; 2005 May;6(3):319-26
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  • [Title] Low postoperative hematocrit increases cerebrovascular damage after hypothermic circulatory arrest.
  • OBJECTIVE: The objective of this study was to evaluate the systemic and cerebral effects of different postoperative hematocrit management following cardiopulmonary bypass and deep hypothermic circulatory arrest.
  • INTERVENTIONS: Twelve piglets were subjected to cardiopulmonary bypass (hematocrit = 25%) and 100 mins of deep hypothermic circulatory arrest (15 degrees C).
  • Near-infrared spectroscopy and immunohistochemical assays for cerebral transforming growth factor-beta(1) and caspase-3 were performed.
  • CONCLUSIONS: Lower postoperative hematocrit was associated with increased fluid retention, lower perfusion pressure, and worse cerebrovascular injury following deep hypothermic circulatory arrest.
  • Postoperative hematocrit management may have profound systemic and cerebral effects after deep hypothermic circulatory arrest and merits further investigation.

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  • (PMID = 15857532.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Oxyhemoglobins; 0 / Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 9008-02-0 / deoxyhemoglobin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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32. Halstead JC, Etz C, Meier DM, Zhang N, Spielvogel D, Weisz D, Bodian C, Griepp RB: Perfusing the cold brain: optimal neuroprotection for aortic surgery. Ann Thorac Surg; 2007 Sep;84(3):768-74; discussion 774
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  • We used a survival porcine model to explore the physiologic characteristics and behavioral benefits of various protocols involving hypothermic circulatory arrest (HCA) and SCP.
  • METHODS: Thirty pigs (26.3 +/- 1.4 kg), cooled to 15 degrees C on cardiopulmonary bypass, using alpha-stat pH management (mean hematocrit 30%), were randomly allocated to differing brain protection strategies: 90 minutes of HCA (group A); 30 minutes of HCA, then 60 minutes of SCP (group B); or 90 minutes of SCP (group C).
  • RESULTS: Cerebral blood flow was significantly higher (p = 0.0001) during SCP (60 and 90 minutes) if preceded by HCA.
  • However, an initial period of HCA does not seem to impair late outcome; perhaps the elevated CBF and CMRO2 observed reflect a beneficial cerebral response to a recoverable insult.
  • Clearly, 90 minutes of HCA induces permanent brain injury, even in this carefully controlled setting.
  • [MeSH-major] Aorta / surgery. Cerebrovascular Circulation. Heart Arrest, Induced

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  • (PMID = 17720373.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
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33. Huurman VA, Stoot JH, van der Linden E, Terpstra OT, Schaapherder AF: Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization. World J Gastroenterol; 2006 Oct 7;12(37):6059-61
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  • [Title] Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization.
  • This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma.
  • The bleeding was stopped by selective embolization of right hepatic artery branches.
  • The patient was discharged without complications, and subsequent follow-up until 22 mo after resection did not reveal any new lesions in the liver.
  • This case emphasizes the significance of selective arterial embolization in the management of bleeding liver tumors and questions the need for (partial) hepatectomy after this procedure in selective cases.
  • [MeSH-major] Adenoma, Liver Cell / complications. Embolization, Therapeutic / methods. Hemorrhage / therapy. Liver Neoplasms / complications
  • [MeSH-minor] Adult. Female. Hepatic Artery / pathology. Humans. Necrosis / pathology

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  • [Cites] J Clin Gastroenterol. 2001 Sep;33(3):234-6 [11500616.001]
  • [Cites] Arch Surg. 2001 Sep;136(9):1033-8 [11529826.001]
  • [Cites] Intern Med. 2001 Sep;40(9):891-5 [11579951.001]
  • [Cites] Zentralbl Chir. 2002 Apr;127(4):326-8 [12085286.001]
  • [Cites] Am Surg. 1996 Oct;62(10):825-9 [8813164.001]
  • [Cites] Br Med J. 1979 Jul 28;2(6184):242-4 [89883.001]
  • [Cites] Gastroenterology. 1981 Sep;81(3):534-6 [6941908.001]
  • [Cites] Ann Surg. 1988 Nov;208(5):558-64 [3190282.001]
  • [Cites] Surg Gynecol Obstet. 1991 Nov;173(5):426-31 [1658955.001]
  • [Cites] JAMA. 1979 Aug 17;242(7):644-8 [221698.001]
  • (PMID = 17009410.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4124419
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34. Chen Y, Zhu SB, Xie MY, Nie SP, Liu W, Li C, Gong XF, Wang YX: Quality control and original discrimination of Ganoderma lucidum based on high-performance liquid chromatographic fingerprints and combined chemometrics methods. Anal Chim Acta; 2008 Aug 15;623(2):146-56
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  • Then different pattern recognition procedures, including hierarchical cluster analysis (HCA), principal component analysis (PCA), partial least squares-discrimination analysis (PLS-DA) and soft independent modeling of class analogy (SIMCA) were applied to classify the G. lucidum samples according to their cultivated origins.
  • Furthermore, four marker constituents were screened out to be the most discriminant variables, which could be applied to accurate discrimination and quality control of G. lucidum by quantitative analysis.
  • [MeSH-minor] Chromatography, High Pressure Liquid. Cluster Analysis. Discriminant Analysis. Pattern Recognition, Automated. Principal Component Analysis. Quality Control

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  • (PMID = 18620918.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal
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35. Sun Y, Sinicrope FA: Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. Mol Cancer Ther; 2005 Jan;4(1):51-9
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  • [Title] Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.
  • Sulindac sulfide inhibits cyclooxygenase (COX)-mediated prostaglandin synthesis and retards the growth of cultured colon cell lines primarily by inducing apoptosis.
  • Given the known role of mitogen-activated protein kinase (MAPK) in signal transduction and the regulation of cell survival and death, we determined the effect of sulindac sulfide on MAPK activation, COX-2 expression, and apoptosis induction in HCA-7 human colon cancer cells.
  • Similar results were seen in HCT-15 cells and also with the selective COX-2 inhibitor NS398.
  • [MeSH-minor] Antineoplastic Agents / toxicity. Cell Line, Tumor. Colonic Neoplasms. Cyclooxygenase Inhibitors / toxicity. Drug Synergism. Flavonoids / toxicity. Humans. Nitrobenzenes / toxicity. Sulfonamides / toxicity

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  • (PMID = 15657353.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK56378
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Enzyme Inhibitors; 0 / Flavonoids; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; 184SNS8VUH / Sulindac; 6UVA8S2DEY / sulindac sulfide; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 2.7.12.2 / MAP Kinase Kinase 1
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36. Brandt K, Langhans W, Geary N, Leonhardt M: Beneficial and deleterious effects of hydroxycitrate in rats fed a high-fructose diet. Nutrition; 2006 Sep;22(9):905-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The present study assessed whether long-term supplementation of a high-fructose diet with hydroxycitrate (HCA), an inhibitor of de novo lipogenesis that is widely used as a non-prescription dietary aid, decreases food intake, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats.
  • METHODS: We examined the effects of HCA (1.8% of diet) on food intake, body weight gain, visceral fat accumulation, hypertriglyceridemia, and hyperinsulinemia in rats during a 4-wk period of ad libitum access to a 50% fructose diet after a 3-wk period of food restriction in which they lost about 20% of their body weight.
  • RESULTS: HCA decreased food intake and weight gain throughout the test and reduced visceral fat accumulation compared with control rats fed ad libitum (CON).
  • Rats that were pair-fed (PF) to the HCA rats showed similar decreases in weight gain and visceral fat.
  • HCA did not ameliorate the hypertriglyceridemia induced by high-fructose feeding.
  • HCA improved insulin sensitivity on day 10 in comparison with CON rats, but by day 27 insulin levels were similarly higher and liver glycogen levels were similarly lower in HCA and CON rats in comparison with PF rats.
  • Liver lipid content was elevated in HCA rats compared with CON and PF rats.
  • CONCLUSION: These findings indicate that, although HCA attenuates body weight gain and visceral fat accumulation by reducing food intake under these conditions, it has no lasting beneficial effects on hypertriglyceridemia and hyperinsulinemia and leads to the accumulation of liver lipids.
  • [MeSH-major] Citrates / administration & dosage. Energy Intake / drug effects. Fructose / administration & dosage. Intra-Abdominal Fat / drug effects. Liver / metabolism. Weight Gain / drug effects

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  • (PMID = 16829028.001).
  • [ISSN] 0899-9007
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Citrates; 30237-26-4 / Fructose; 8W94T9026R / hydroxycitric acid
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37. Meybohm P, Hoffmann G, Renner J, Boening A, Cavus E, Steinfath M, Scholz J, Bein B: Measurement of blood flow index during antegrade selective cerebral perfusion with near-infrared spectroscopy in newborn piglets. Anesth Analg; 2008 Mar;106(3):795-803, table of contents
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  • BACKGROUND: Neonates with complex congenital heart defects have traditionally undergone surgery during deep hypothermic cardiac arrest (HCA).
  • We investigated SCP with different flow rates compared with HCA with respect to cerebral perfusion and tissue oxygenation as assessed by near-infrared spectroscopy.
  • METHODS: Twenty-one piglets were placed on cardiopulmonary bypass at 18 degrees C, then underwent either HCA or SCP at 25 or 50 mL x kg(-1) x min(-1) for 90 min.
  • RESULTS: Both BFI and FV(mean) increased significantly (126 +/- 27% of baseline; 19 +/- 2 cm/s) in the SCP 50 group compared with HCA (no flow) and SCP 25 (65 +/- 24%; 10 +/- 1 cm/s), respectively.
  • TOI increased in the SCP 50 group compared with baseline (74 +/- 4% vs 65 +/- 4%), and was higher compared with HCA (52 +/- 2%) and SCP 25 (59 +/- 2%).
  • CONCLUSIONS: Both BFI and FV(mean) suggested increased cerebral perfusion in the SCP 50 group compared with the HCA and SCP 25 groups.
  • TOI was significantly higher in both the SCP 25 and SCP 50 groups compared with HCA.
  • [MeSH-major] Brain / blood supply. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / adverse effects. Cerebrovascular Circulation. Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Monitoring, Intraoperative / methods. Perfusion / methods. Spectroscopy, Near-Infrared


38. Nishimura O, Suzuki T, Hosoba S, Takashima N, Hiramatsu N, Kinoshita T, Kambara A, Matsubayashi K, Asai T: [Acute type A aortic dissection, developed shortly after aortic valve replacement and coronary artery bypass grafting]. Kyobu Geka; 2010 Dec;63(13):1141-4
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  • Under hypothermic circulatory arrest with femoral arterial and venous cannulations, the ascending aorta was replaced and re-implantation of the saphenous vein graft was carried out.
  • [MeSH-major] Aneurysm, Dissecting / etiology. Aortic Aneurysm, Thoracic / etiology. Coronary Artery Bypass. Heart Valve Prosthesis Implantation
  • [MeSH-minor] Acute Disease. Aged. Angina Pectoris / surgery. Aortic Valve Insufficiency / surgery. Humans. Male. Postoperative Complications. Reoperation

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  • (PMID = 21174664.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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39. De Francesco MA, Gargiulo F, Schreiber C, Ciravolo G, Salinaro F, Manca N: Detection and genotyping of human papillomavirus in cervical samples from Italian patients. J Med Virol; 2005 Apr;75(4):588-92
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  • In order to assess the epidemiological incidence and frequency of different HPV types, we applied a polymerase chain reaction (PCR)-direct sequencing approach based on the use of MY09/MY11 primers as compared to Hybrid Capture assay.
  • [MeSH-minor] Adolescent. Adult. Carcinoma in Situ / virology. Female. Genotype. Humans. Italy. Middle Aged. Sequence Analysis, DNA

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15714493.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Galloro V: Emory, HCA to end venture. Cultural differences, control cited as obstacles. Mod Healthc; 2010 Jul 19;40(29):16
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  • [Title] Emory, HCA to end venture. Cultural differences, control cited as obstacles.

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  • (PMID = 20695116.001).
  • [ISSN] 0160-7480
  • [Journal-full-title] Modern healthcare
  • [ISO-abbreviation] Mod Healthc
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
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41. De Felice C, Goldstein MR, Parrini S, Verrotti A, Criscuolo M, Latini G: Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis. Pediatr Crit Care Med; 2006 Mar;7(2):138-42
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  • OBJECTIVE: No reliable clinical markers of histologic chorioamnionitis (HCA), a major and often subclinical cause of prematurity leading to high neonatal morbidity and mortality, are available to date.
  • PATIENTS AND INTERVENTION: Pulse oximetry-derived signals (pulse rate, oxygen saturation, and perfusion index), recorded within the first 1.5 hrs of life, were analyzed for 110 very low-birth-weight infants, of whom 54 had histopathological evidence of HCA.
  • MEASUREMENTS AND MAIN RESULTS: Four different time series parameters were determined for nonlinear dynamical (NLD) analysis.
  • Significantly decreased Lempel-Ziv, Lyapunov largest exponent, and correlation dimension, with significantly increased Hurst values for heart rate and perfusion index (p < .00001), were observed in newborns with HCA.
  • Heart rate Lempel-Ziv </=0.218 showed 100% sensitivity (95% confidence interval, 98.8-100) and 100% specificity (95% confidence interval, 98.6-100) in distinguishing cases from controls, with positive and negative predictive values of 100% and 95.7%, respectively.
  • CONCLUSIONS: Our findings indicate that early autonomic tone balance abnormalities are present in newborns with HCA and suggest that early dynamic analysis of pulse oximetry signals could be useful in identifying affected infants.
  • [MeSH-major] Chorioamnionitis / diagnosis. Chorioamnionitis / pathology. Infant, Premature

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  • (PMID = 16474255.001).
  • [ISSN] 1529-7535
  • [Journal-full-title] Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • [ISO-abbreviation] Pediatr Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Trask OJ, Nickischer D, Burton A, Williams RG, Kandasamy RA, Johnston PA, Johnston PA: High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer. Methods Mol Biol; 2009;565:159-86
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  • [Title] High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer.
  • The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation through preclinical candidate selection.
  • In this chapter we describe the development, validation, and implementation of an HCS assay to screen compounds from a kinase-focused small-molecule library to identify inhibitors of the p38 pathway using the GE InCell 3000 automated imaging platform.
  • The assay utilized a genetically modified HeLa cell line stably expressing mitogen-activated, protein-activating protein kinase-2 fused to enhanced green fluorescent protein (MK2-EGFP) and measured the subcellular distribution of the MK2-EGFP as a direct readout of p38 activation.
  • The MK2-EGFP translocation assay performed in 384-well glass bottom microtiter plates exhibited a robust Z-factor of 0.46 and reproducible EC50 and IC50 determinations for activators and inhibitors, respectively.
  • Thirty-one compounds exhibited IC50s less than 1 microM, and at least one novel structural class of p38 inhibitor was identified using this HCA/HCS chemical biology screening approach.
  • [MeSH-major] Drug Evaluation, Preclinical / methods. Enzyme Inhibitors / analysis. Microscopy, Confocal / methods. p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • [MeSH-minor] Calcium / metabolism. HeLa Cells. Humans

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  • (PMID = 19551362.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; SY7Q814VUP / Calcium
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43. Wu Y, Na N, Zhang S, Wang X, Liu D, Zhang X: Discrimination and identification of flavors with catalytic nanomaterial-based optical chemosensor array. Anal Chem; 2009 Feb 1;81(3):961-6
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  • Hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA) were used to analyze the patterns.
  • [MeSH-major] Flavoring Agents / analysis. Luminescent Measurements / methods. Nanostructures / chemistry
  • [MeSH-minor] Catalysis. Discriminant Analysis. Metal Nanoparticles / chemistry. Nanotubes, Carbon / chemistry. Temperature. Time Factors

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  • (PMID = 19119818.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flavoring Agents; 0 / Nanotubes, Carbon
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44. Basaran I, Sinan S, Cakir U, Bulut M, Arslan O, Ozensoy O: In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds. J Enzyme Inhib Med Chem; 2008 Feb;23(1):32-6
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  • These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.

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  • (PMID = 18341250.001).
  • [ISSN] 1475-6366
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coumarins; 0 / Enzyme Inhibitors; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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45. Choi JC, Baek YH, Jeong JS, Lee SW, Han SY, Cho JH: Discrete hypoechoic ring in hepatic cavernous hemangioma resembling a malignant tumor: correlation with histologic features. Gut Liver; 2009 Sep;3(3):226-30
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  • [Title] Discrete hypoechoic ring in hepatic cavernous hemangioma resembling a malignant tumor: correlation with histologic features.
  • Differential diagnoses of hepatic nodules include hepatocellular carcinoma, focal nodular hyperplasia, hepatic adenoma, regenerative nodule, focal fatty changes, and hemangioma.
  • We report herein the case of an atypical hemangioma presenting with a hypoechoic peripheral ring, mimicking a hepatic malignancy.

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  • [Cites] Gastrointest Radiol. 1989 Summer;14(3):262-4 [2659425.001]
  • [Cites] AJR Am J Roentgenol. 1987 Nov;149(5):953-7 [3314430.001]
  • [Cites] AJR Am J Roentgenol. 1986 Jun;146(6):1149-53 [3518366.001]
  • [Cites] AJR Am J Roentgenol. 1983 Jan;140(1):41-5 [6600323.001]
  • [Cites] J Clin Ultrasound. 1982 Oct;10(8):373-8 [6816817.001]
  • [Cites] Am J Surg. 1983 Jan;145(1):49-53 [6849494.001]
  • [Cites] J Gastroenterol Hepatol. 2008 Oct;23(10):1528-34 [17944882.001]
  • [Cites] AJR Am J Roentgenol. 1998 Oct;171(4):1021-5 [9762989.001]
  • [Cites] Radiology. 2001 Apr;219(1):69-74 [11274536.001]
  • [Cites] Eur Radiol. 2001;11(9):1578-93 [11511877.001]
  • [Cites] Korean J Radiol. 2000 Oct-Dec;1(4):191-7 [11752954.001]
  • [Cites] AJR Am J Roentgenol. 2003 Jan;180(1):135-41 [12490492.001]
  • [Cites] Radiology. 1993 Aug;188(2):413-7 [8327687.001]
  • (PMID = 20431752.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852708
  • [Keywords] NOTNLM ; Hemangioma / Hepatic malignancy / Hypoechoic ring / Ultrasonography
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46. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res; 2007 Oct;142(2):239-45
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  • Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells.
  • For in vitro studies, HCA-7 cells were treated with Ro26-2198 followed by interleukin-1beta (IL-1beta).
  • Proliferation was measured by WST-1 assay.
  • In vitro, Ro26-2198 inhibited IL-1beta-induced ERK activation and COX-2 induction and decreased HCA-7 cell proliferation.
  • [MeSH-minor] Animals. Anti-Inflammatory Agents / pharmacology. Cell Division / drug effects. Cell Line, Tumor. Colon / metabolism. Colon / pathology. Cyclooxygenase 2 / metabolism. Disease Models, Animal. Extracellular Signal-Regulated MAP Kinases / metabolism. Humans. Interleukin-1beta / pharmacology. MAP Kinase Signaling System / drug effects. Male. Mice. Mice, Inbred A. Proto-Oncogene Proteins c-myc / metabolism. Up-Regulation / drug effects

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  • (PMID = 17574271.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA036745; United States / NIDDK NIH HHS / DK / DK42086
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 1,25(OH)2-16-ene-23-yne-26,27-hexafluoro-19-nor-D3; 0 / Anti-Inflammatory Agents; 0 / Interleukin-1beta; 0 / Proto-Oncogene Proteins c-myc; 1C6V77QF41 / Cholecalciferol; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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47. Ueda T, Taguchi S, Inoue Y, Kashima I: Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation. Interact Cardiovasc Thorac Surg; 2007 Feb;6(1):85-6
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  • [Title] Hypothermic circulatory arrest through a left thoracotomy in a 12-year-old child with aortic coarctation.
  • Surgical correction of adult complex aortic coarctation using hypothermic circulatory arrest often requires central cannulation to secure cerebral perfusion.
  • [MeSH-major] Aortic Coarctation / surgery. Heart Arrest, Induced. Hypothermia, Induced. Thoracotomy / methods

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  • (PMID = 17669776.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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48. Kim SA, Sung YK, Kwon BM, Yoon JH, Lee H, Ahn SG, Hong SH: 2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor model. Anticancer Res; 2010 Feb;30(2):489-94
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  • BACKGROUND: 2'-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines.
  • MATERIALS AND METHODS: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model.
  • RESULTS: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G(2)/M-phase and increased the number of cells in the sub-G(1) (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells.
  • Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass.
  • Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model.
  • CONCLUSION: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Apoptosis / drug effects. Cell Cycle / drug effects. Cinnamates / pharmacology. Mouth Neoplasms / drug therapy. Xenograft Model Antitumor Assays
  • [MeSH-minor] Animals. Blotting, Western. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Cell Proliferation / drug effects. Humans. Immunoenzyme Techniques. In Vitro Techniques. Male. Rats. Rats, Sprague-Dawley

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  • (PMID = 20332459.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cinnamates; 0 / p-hydroxycinnamaldehyde
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49. Petsas T, Tsamandas A, Tsota I, Karavias D, Karatza C, Vassiliou V, Kardamakis D: A case of hepatocellular carcinoma arising within large focal nodular hyperplasia with review of the literature. World J Gastroenterol; 2006 Oct 28;12(40):6567-71
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  • [Title] A case of hepatocellular carcinoma arising within large focal nodular hyperplasia with review of the literature.
  • Focal nodular hyperplasia (FNH) is a relatively rare benign hepatic tumor, usually presenting as a solitary lesion; however, multiple localizations have also been described.
  • The association of FNH with other hepatic lesions, such as adenomas and haemangiomas has been reported by various authors.
  • We herein report a case of a hepatocellular carcinoma arising within a large focal nodular hyperplasia, in a young female patient.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Focal Nodular Hyperplasia / complications. Liver Neoplasms / etiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • [Cites] Eur Radiol. 2001;11(2):202-12 [11218015.001]
  • [Cites] Mod Pathol. 1989 Sep;2(5):456-62 [2813344.001]
  • [Cites] Radiology. 2001 Apr;219(1):61-8 [11274535.001]
  • [Cites] J Pediatr Surg. 2001 Apr;36(4):622-5 [11283891.001]
  • [Cites] Virchows Arch. 2001 Apr;438(4):408-11 [11355178.001]
  • [Cites] Br J Surg. 2001 Jun;88(6):808-13 [11412249.001]
  • [Cites] Arch Surg. 2001 Sep;136(9):1033-8 [11529826.001]
  • [Cites] J Gastroenterol Hepatol. 2003 Feb;18(2):227-30 [12542613.001]
  • [Cites] Tumori. 2003 Jul-Aug;89(4):434-6 [14606650.001]
  • [Cites] Hum Pathol. 1976 Sep;7(5):533-45 [964980.001]
  • [Cites] JAMA. 1984 Mar 16;251(11):1461-3 [6700042.001]
  • [Cites] Am J Clin Pathol. 1984 Apr;81(4):521-6 [6322571.001]
  • [Cites] Hepatology. 1984 May-Jun;4(3):536-40 [6724520.001]
  • [Cites] Hepatology. 1985 Nov-Dec;5(6):1194-200 [4065824.001]
  • [Cites] Cancer. 1987 Dec 15;60(12):3049-55 [2824023.001]
  • [Cites] Gut. 1990 May;31(5):554-5 [2082949.001]
  • [Cites] Gastrointest Radiol. 1992 Winter;17(1):63-73 [1312050.001]
  • [Cites] Radiology. 1992 Sep;184(3):699-703 [1509052.001]
  • [Cites] Arch Surg. 1994 Jul;129(7):712-7 [7517661.001]
  • [Cites] Hepatology. 1995 Dec;22(6):1674-81 [7489973.001]
  • [Cites] Am J Pathol. 1996 Apr;148(4):1089-96 [8644851.001]
  • [Cites] J Clin Ultrasound. 1996 Sep;24(7):345-50 [8873856.001]
  • [Cites] Hepatology. 1997 Oct;26(4):891-5 [9328310.001]
  • [Cites] World J Surg. 1997 Nov-Dec;21(9):983-90; discussion 990-1 [9361515.001]
  • [Cites] AJR Am J Roentgenol. 1998 Feb;170(2):391-5 [9456952.001]
  • [Cites] Br J Surg. 1998 Mar;85(3):315-9 [9529482.001]
  • [Cites] J Gastroenterol. 1998 Dec;33(6):904-8 [9853570.001]
  • [Cites] Gastroenterology. 1999 Jul;117(1):284-5 [10428616.001]
  • [Cites] World J Gastroenterol. 2006 Apr 7;12(13):2125-9 [16610069.001]
  • [Cites] Gastroenterology. 1987 Dec;93(6):1409-13 [2824277.001]
  • [Cites] Gastroenterology. 1989 Jul;97(1):154-7 [2542117.001]
  • [Cites] Am Surg. 2001 Feb;67(2):173-8 [11243545.001]
  • (PMID = 17072995.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 33
  • [Other-IDs] NLM/ PMC4100652
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50. Woods CG, Burns AM, Bradford BU, Ross PK, Kosyk O, Swenberg JA, Cunningham ML, Rusyn I: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicol Sci; 2007 Aug;98(2):366-74
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  • [Title] WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.
  • Long-term exposure of rodents to peroxisome proliferators leads to increases in peroxisomes, hepatocellular proliferation, oxidative damage, suppressed apoptosis, and ultimately results in the development of hepatic adenomas and carcinomas.
  • Peroxisome proliferators-activated receptor (PPAR)alpha was shown to be required for these pleiotropic responses; however, Kupffer cells, resident liver macrophages, were also identified as playing a role in peroxisome proliferators-induced effects, independently of PPARalpha.
  • Previous studies showed that oxidants from NADPH (nicotinamide adenine dinucleotide phosphate, reduced) oxidase mediate acute effects of peroxisome proliferators in rodent liver.
  • To determine if Kupffer cell oxidants are also involved in chronic effects, NADPH oxidase-deficient (p47(phox)-null) mice were fed 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (WY-14,643)-containing diet (0.1% wt/wt) for 1 week, 5 weeks, or 5 months along with Pparalpha-null and wild type mice.
  • As expected, no change in liver size, cell replication rates, or other phenotypic effects of peroxisome proliferators were observed in Pparalpha-null mice.
  • Through 5 months of treatment, the p47(phox)-null and wild type mice exhibited peroxisome proliferators-induced adverse liver effects, along with increased oxidative DNA damage and increased cell proliferation, a response that is potentially mediated through nuclear factor kappa B (NFkB).
  • Collectively, these findings suggest that involvement of Kupffer cells in WY-14,643-induced parenchymal cell proliferation and oxidative stress in rodent liver is an acute phenomenon that is not relevant to long-term exposure, but they are still involved in chronic apoptotic responses.
  • [MeSH-major] Liver / drug effects. PPAR alpha / deficiency. Peroxisome Proliferators / toxicity. Pyrimidines / toxicity
  • [MeSH-minor] Acyl-CoA Oxidase / metabolism. Animals. Apoptosis / drug effects. Body Weight / drug effects. Caspase 8 / metabolism. Caspase 9 / metabolism. Cell Cycle Proteins / metabolism. Cell Proliferation / drug effects. DNA Damage. Male. Mice. Mice, Knockout. NADPH Oxidase / deficiency. NADPH Oxidase / genetics. Organ Size / drug effects. Oxidative Stress

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  • (PMID = 17483499.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / F32-ES13342; United States / NIEHS NIH HHS / ES / K22-ES11660; United States / NIEHS NIH HHS / ES / P30-ES10126; United States / NIEHS NIH HHS / ES / R01-ES12686; United States / NIEHS NIH HHS / ES / U19-ES11391
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / PPAR alpha; 0 / Peroxisome Proliferators; 0 / Pyrimidines; 86C4MRT55A / pirinixic acid; EC 1.3.3.6 / Acyl-CoA Oxidase; EC 1.6.3.1 / NADPH Oxidase; EC 1.6.3.1 / neutrophil cytosolic factor 1; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspase 9
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51. Terkivatan T, Ijzermans JN: Hepatocellular adenoma: Should phenotypic classification direct management? Nat Rev Gastroenterol Hepatol; 2009 Dec;6(12):697-8
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  • [Title] Hepatocellular adenoma: Should phenotypic classification direct management?
  • [MeSH-major] Adenoma, Liver Cell / classification. Adenoma, Liver Cell / metabolism. Liver Neoplasms / classification. Liver Neoplasms / metabolism

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  • (PMID = 19946304.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] England
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52. Muniz Filho RC, de Sousa SA, Pereira Fda S, Ferreira MM: Theoretical study of acid-catalyzed hydrolysis of epoxides. J Phys Chem A; 2010 Apr 22;114(15):5187-94
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  • By using chemometric tools, hierarchical cluster analysis (HCA), and principal component analysis (PCA), the MP2/6-311++G** level of theory was selected from HF, MP2, and DFT as the best method to describe the geometry of the basic skeleton (oxirane).
  • In the S(N)1 mechanism, the existence of the typical carbocation was not observed, and furthermore, the possibility of epoxide conversion to a protonated aldehyde was indicated, even in the presence of a water molecule (nucleophile).

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  • (PMID = 20334442.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Wang HL, Anatelli F, Zhai QJ, Adley B, Chuang ST, Yang XJ: Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions. Arch Pathol Lab Med; 2008 Nov;132(11):1723-8
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  • [Title] Glypican-3 as a useful diagnostic marker that distinguishes hepatocellular carcinoma from benign hepatocellular mass lesions.
  • CONTEXT: Histopathologic distinction between hepatocellular carcinoma (HCC) and benign hepatocellular mass lesions, particularly hepatocellular adenoma, can sometimes be challenging.
  • OBJECTIVE: To further characterize the diagnostic value of glypican-3 (GPC3), a cell surface proteoglycan that has recently been shown to be overexpressed in HCC, in the distinction between HCC and benign hepatocellular mass lesions.
  • DESIGN: A total of 221 surgically resected liver specimens were subjected to immunohistochemical staining using a monoclonal antibody specific for GPC3.
  • These included 111 HCCs, 48 hepatocellular adenomas, 30 focal nodular hyperplasias, and 32 large regenerative nodules in the background of cirrhosis.
  • In contrast, none of the 110 cases of hepatocellular adenoma, focal nodular hyperplasia, and large regenerative nodule showed detectable GPC3 staining.
  • CONCLUSIONS: GPC3 is a specific immunomarker for HCC that can be used to distinguish HCC from benign hepatocellular mass lesions, particularly hepatocellular adenoma.
  • However, the diagnosis of HCC should not rely entirely on positive GPC3 immunostaining because focal immunoreactivity can be detected in a small subset of cirrhotic nodules.
  • In addition, GPC3 expression in HCC can also be focal, and thus, the lack of GPC3 staining does not exclude the diagnosis of HCC.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Biomarkers, Tumor / metabolism. Carcinoma, Hepatocellular / diagnosis. Glypicans / metabolism. Liver Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Child. Diagnosis, Differential. Female. Focal Nodular Hyperplasia / diagnosis. Focal Nodular Hyperplasia / metabolism. Focal Nodular Hyperplasia / pathology. Humans. Liver / pathology. Liver Cirrhosis / diagnosis. Liver Cirrhosis / metabolism. Liver Cirrhosis / pathology. Male. Middle Aged

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  • (PMID = 18976006.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glypicans
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54. Mazzei P, Francesca N, Moschetti G, Piccolo A: NMR spectroscopy evaluation of direct relationship between soils and molecular composition of red wines from Aglianico grapes. Anal Chim Acta; 2010 Jul 19;673(2):167-72
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  • The careful subtraction of water and ethanol signals from NMR spectra allowed to statistically recognize the metabolites to be employed in multivariate statistical methods: Principal Component Analysis (PCA), Discriminant Analysis (DA) and Hierarchical Clustering Analysis (HCA).
  • All multivariate analyses confirmed that the differentiation among the wines were related to micro-climate, and carbonate, clay, and organic matter content of soils.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20599031.001).
  • [ISSN] 1873-4324
  • [Journal-full-title] Analytica chimica acta
  • [ISO-abbreviation] Anal. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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55. Karni M, Bernasconi CF, Rappoport Z: Role of negative hyperconjugation and anomeric effects in the stabilization of the intermediate in SNV reactions. J Org Chem; 2008 Apr 18;73(8):2980-94
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  • The hyperconjugation ability (HCA) (i.e., the stabilization due to 2p(Calpha) --> sigma*(Cbeta-X) interaction) in 8b-8d follows the order (for X, kcal/mol) CH3S (8.5) > CF3CH2O (7.6) approximately CH3O (7.5).
  • The HCA in 8b-8d is significantly smaller than that in 7b-7d due to charge delocalization in Mu in the former.

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  • (PMID = 18376875.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Went PT, Sauter G, Oberholzer M, Bubendorf L: Abundant expression of AMACR in many distinct tumour types. Pathology; 2006 Oct;38(5):426-32
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  • AIMS: Alpha-methylacyl-CoA racemase (AMACR), a mitochondrial and peroxisomal enzyme, is a valuable tool to confirm the diagnosis of prostate cancer, especially if combined with basal cell markers.
  • METHODS: We performed immunohistochemical analyses on tissue microarrays of AMACR expression in over 125 different human tumour types and 80 normal tissues.
  • RESULTS: Microarray analysis revealed that tumours with prominent AMACR expression included adenocarcinomas of the prostate (72%), hepatocellular carcinomas (77%), papillary renal cell carcinomas (70%), and colorectal adenocarcinomas (71%).
  • AMACR expression was equally frequent in colorectal adenomas and carcinomas.
  • In the thyroid, AMACR expression was found in 42% of the follicular carcinomas but in only 16% of follicular adenomas.
  • However, a more detailed analysis on a thyroid tissue microarray did not confirm a significant difference of AMACR expression in follicular adenoma and carcinomas.
  • [MeSH-minor] Female. Humans. Immunoenzyme Techniques. Male. Tissue Array Analysis

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  • (PMID = 17008281.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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57. Anderl JL, Redpath S, Ball AJ: A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity. J Vis Exp; 2009;(27)
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  • [Title] A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity.
  • High Content Analysis (HCA) assays combine cells and detection reagents with automated imaging and powerful image analysis algorithms, allowing measurement of multiple cellular phenotypes within a single assay.
  • In this study, we utilized HCA to develop a novel assay for neurotoxicity.
  • Recently, the application of HCA to neuronal screening has been reported.
  • By labeling neuronal cells with betaIII-tubulin, HCA assays can provide high-throughput, non-subjective, quantitative measurements of parameters such as neuronal number, neurite count and neurite length, all of which can indicate neurotoxic effects.
  • Astrocytes have an integral role in the maintenance of central nervous system (CNS) homeostasis, and are associated with both neuroprotection and neurodegradation when they are activated in response to toxic substances or disease states.
  • This approach is limited by an inability to provide information on cellular localization, morphology and cell number.
  • We determined that HCA could be used to overcome these limitations and to simultaneously measure multiple features associated with gliosis - changes in GFAP expression, astrocyte hypertrophy, and astrocyte proliferation - within a single assay.
  • Recent studies have suggested that the use of astrocytes in an in vitro neurotoxicity test system may prove more relevant to human CNS structure and function than neuronal cells alone.
  • Accordingly, we have developed an HCA assay for co-culture of neurons and astrocytes, comprised of protocols and validated, target-specific detection reagents for profiling betaIII-tubulin and glial fibrillary acidic protein (GFAP).
  • This assay enables simultaneous analysis of neurotoxicity, neurite outgrowth, gliosis, neuronal and astrocytic morphology and neuronal and astrocytic development in a wide variety of cellular models, representing a novel, non-subjective, high-throughput assay for neurotoxicity assessment.
  • The assay holds great potential for enhanced detection of neurotoxicity and improved productivity in neuroscience research and drug discovery.

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  • [Cites] Endocr Relat Cancer. 2000 Mar;7(1):63-71 [10808197.001]
  • [Cites] J Neurosci Methods. 2008 Oct 30;175(1):96-103 [18761375.001]
  • [Cites] Neurochem Res. 2000 Oct;25(9-10):1439-51 [11059815.001]
  • [Cites] Toxicol Lett. 2004 Aug 30;152(1):35-46 [15294345.001]
  • [Cites] Arch Toxicol. 1998 May;72(6):372-80 [9657285.001]
  • [Cites] Expert Opin Drug Saf. 2005 May;4(3):433-42 [15934851.001]
  • [Cites] Assay Drug Dev Technol. 2006 Apr;4(2):143-52 [16712418.001]
  • [Cites] Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):701-13 [16863434.001]
  • [Cites] Brain Res. 2007 Jan 19;1129(1):43-52 [17169340.001]
  • [Cites] Glia. 2007 Aug 15;55(11):1156-68 [17597119.001]
  • [Cites] J Neurol Sci. 2007 Nov 15;262(1-2):7-14 [17764698.001]
  • [Cites] Toxicology. 2007 Nov 20;241(1-2):75-83 [17875352.001]
  • [Cites] Toxicol In Vitro. 2007 Oct;21(7):1241-6 [17566694.001]
  • [Cites] Toxicol In Vitro. 2008 Feb;22(1):1-9 [17761398.001]
  • [Cites] J Neurosci. 2008 Mar 5;28(10):2394-408 [18322086.001]
  • [Cites] Neurotoxicology. 2008 May;29(3):361-76 [18403021.001]
  • [Cites] Toxicol Sci. 2008 Sep;105(1):106-18 [18539913.001]
  • [Cites] Toxicol Sci. 2008 Sep;105(1):119-33 [18550602.001]
  • [Cites] Eur J Biochem. 2000 Aug;267(16):4912-6 [10931173.001]
  • (PMID = 19417729.001).
  • [ISSN] 1940-087X
  • [Journal-full-title] Journal of visualized experiments : JoVE
  • [ISO-abbreviation] J Vis Exp
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3253581
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58. Jeon YK, Cheon JE, Kim SK, Wang KC, Cho BK, Park SH: Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. Mod Pathol; 2008 Nov;21(11):1345-56
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  • [Title] Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization.
  • The presence of a pilomyxoid area was associated with shorter survival.
  • An unsupervised hierarchical clustering analysis classified the cases into three clusters: one pilomyxoid astrocytoma patient into one cluster, two pilomyxoid astrocytoma patients into another cluster, and six pilocytic astrocytoma patients and one pilomyxoid astrocytoma patient into the third cluster.
  • In conclusion, the presence of mixed-form pilomyxoid astrocytoma, the acquisition of pilocytic astrocytoma features in a recurrent tumor in pure-form pilomyxoid astrocytoma, and the above results of the genome-wide gene copy number analysis suggest that pilomyxoid astrocytoma might be a pathologically and genetically related, aggressive variant of pilocytic astrocytoma with partially different genetic alterations.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / analysis. Brain / pathology. Child. Child, Preschool. Clone Cells. DNA, Neoplasm / genetics. Female. Humans. Immunoenzyme Techniques. Infant. Magnetic Resonance Imaging. Male. Neoplasm Recurrence, Local. Survival Rate. Young Adult

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  • (PMID = 18622384.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm
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59. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR: Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res; 2007 May 15;67(10):4586-94
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  • [Title] Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.
  • Hepatocellular carcinoma (HCC) with p53 mutations is usually characterized by extensive chromosomal instability (CIN), whereas those with beta-catenin mutations have relatively less CIN and the molecular pathogenesis of these tumors is unknown.
  • Methylation of 21 genetic loci was quantitated using combined bisulfite restriction analysis.
  • Using hierarchical clustering analysis based upon the quantification of methylation levels, all HCCs were segregated into two groups characterized by either limited or extensive methylation.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Cell Transformation, Neoplastic / genetics. DNA Methylation. Liver Neoplasms / genetics. beta Catenin / genetics

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  • [ErratumIn] Cancer Res. 2007 Jun 15;67(12):5998. Ajay, Goel [corrected to Goel, Ajay]
  • (PMID = 17510384.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA72851; United States / NCI NIH HHS / CA / R01 CA98572
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
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60. Panos A, Murith N, Bednarkiewicz M, Khatchatourov G: Axillary cerebral perfusion for arch surgery in acute type A dissection under moderate hypothermia. Eur J Cardiothorac Surg; 2006 Jun;29(6):1036-9
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  • Adequate brain protection is essential and commonly performed by either antegrade selective perfusion of the brachiocephalic arteries or an interval of profound hypothermic circulatory arrest.
  • The mean duration of circulatory arrest of the lower body and brain perfusion was 39.7 (range, 24-55 min).
  • CONCLUSIONS: The absence of any major permanent neurologic deficit or any visceral damages in our patients suggests that continuous moderate hypothermic cerebral perfusion, with an interval of circulatory arrest of the lower body, is adequate for acute type A aortic dissection surgery, allowing safe open repair of the distal aortic arch.
  • [MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Axillary Artery. Brain Ischemia / prevention & control. Cardiopulmonary Bypass / methods. Catheterization, Peripheral / methods. Female. Humans. Male. Middle Aged. Perfusion / methods. Treatment Outcome

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  • [CommentIn] Eur J Cardiothorac Surg. 2006 Nov;30(5):815-6; author reply 816-7 [16956768.001]
  • [CommentIn] Eur J Cardiothorac Surg. 2006 Jun;29(6):1039-40 [16675223.001]
  • (PMID = 16675240.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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61. Hidayat W, Shakaff AY, Ahmad MN, Adom AH: Classification of agarwood oil using an electronic nose. Sensors (Basel); 2010;10(5):4675-85
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  • Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA), were used to classify different types of oil.
  • The HCA produced a dendrogram showing the separation of e-nose data into three different groups of oils.
  • [MeSH-major] Electronic Nose. Plant Oils / analysis. Thymelaeaceae / chemistry
  • [MeSH-minor] Algorithms. Cluster Analysis. Neural Networks (Computer). Odorants / analysis. Principal Component Analysis

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  • (PMID = 22399899.001).
  • [ISSN] 1424-8220
  • [Journal-full-title] Sensors (Basel, Switzerland)
  • [ISO-abbreviation] Sensors (Basel)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Plant Oils
  • [Other-IDs] NLM/ PMC3292139
  • [Keywords] NOTNLM ; ANN (major topic) / HCA (major topic) / PCA (major topic) / agarwood oil (major topic) / dimensionality reduction (major topic) / e-nose (major topic)
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62. Meyers RL: Tumors of the liver in children. Surg Oncol; 2007 Nov;16(3):195-203
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  • [Title] Tumors of the liver in children.
  • In this review we examine the diagnosis and treatment of pediatric liver tumors- both malignant and benign.
  • The two most common malignant tumors are hepatoblastoma and hepatocellular carcinoma.
  • Hepatoblastoma is seen in younger children, hepatocellular carcinoma in older children.
  • Other malignant liver tumors are quite rare and include biliary rhabdomyosarcoma, angiosarcoma, rhabdoid tumor, and undifferentiated sarcoma.
  • The commonly seen benign liver tumors in children are infantile hemangioma, mesenchymal hamartoma, and focal nodular hyperplasia.
  • Rare benign tumors are hepatic adenoma, which is occasionally seen in teenage girls, and teratoma which is a very rare liver tumor in infants.
  • [MeSH-major] Liver Neoplasms

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  • (PMID = 17714939.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 69
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63. Kang M, Akbarali HI: Denitration of L-type calcium channel. FEBS Lett; 2008 Sep 3;582(20):3033-6
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  • Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCa(v)1.2b.
  • Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Ca(v)1.2 in a 1D gel assay.
  • Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates.

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  • [Cites] Front Biosci. 2003 Jan 1;8:d264-78 [12456375.001]
  • [Cites] Mol Cell Biochem. 1999 Nov;201(1-2):11-6 [10630617.001]
  • [Cites] Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1184-9 [14604848.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4003-8 [15020765.001]
  • [Cites] Proc Natl Acad Sci U S A. 1990 Feb;87(4):1620-4 [2154753.001]
  • [Cites] Gastroenterology. 1991 Nov;101(5):1289-97 [1936799.001]
  • [Cites] Arch Biochem Biophys. 1992 Nov 1;298(2):431-7 [1416974.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3377-82 [8622943.001]
  • [Cites] Gastroenterology. 1996 Oct;111(4):871-85 [8831582.001]
  • [Cites] Scand J Gastroenterol. 1997 Nov;32(11):1107-17 [9399391.001]
  • [Cites] J Biol Chem. 1998 Feb 27;273(9):5337-42 [9478993.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11584-9 [9751709.001]
  • [Cites] FEBS Lett. 2007 Jan 9;581(1):84-90 [17174954.001]
  • [Cites] J Pharmacol Exp Ther. 2007 Sep;322(3):948-56 [17551092.001]
  • [Cites] Biochemistry. 2007 Sep 18;46(37):10498-505 [17711305.001]
  • [Cites] Am J Physiol Cell Physiol. 2007 Dec;293(6):C1983-90 [17942635.001]
  • [Cites] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5634-9 [12719531.001]
  • (PMID = 18675806.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK046367-17; United States / NIDDK NIH HHS / DK / R01 DK046367; United States / NIDDK NIH HHS / DK / DK46367; United States / NIDDK NIH HHS / DK / R01 DK046367-17
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CACNA1C protein, human; 0 / Calcium Channels, L-Type; 0 / Nitrates; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine
  • [Other-IDs] NLM/ NIHMS68998; NLM/ PMC2533528
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64. Yan S, Luo G, Wang Y, Cheng Y: Simultaneous determination of nine components in Qingkailing injection by HPLC/ELSD/DAD and its application to the quality control. J Pharm Biomed Anal; 2006 Mar 3;40(4):889-95
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  • This assay was fully validated in respect to precision, repeatability and accuracy.
  • The proposed method was successfully applied to quantify the nine ingredients in 19 different Qingkailing injection samples and by principal component analysis (PCA) and hierarchical clustering analysis (HCA), it demonstrated significant variations in the content of these compounds in the samples from different manufacturers and preparation procedures.
  • [MeSH-minor] Cluster Analysis. Light. Principal Component Analysis. Quality Control. Reproducibility of Results. Scattering, Radiation. Spectrophotometry, Ultraviolet

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  • (PMID = 16257167.001).
  • [ISSN] 0731-7085
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Qingkailing
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65. Galusca B, Dumollard JM, Lassandre S, Niveleau A, Prades JM, Estour B, Peoc'h M: Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia. Virchows Arch; 2005 Jul;447(1):18-23
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  • [Title] Global DNA methylation evaluation: potential complementary marker in differential diagnosis of thyroid neoplasia.
  • The study aimed to evaluate the status of global DNA methylation in several types of thyroid tumors using a monoclonal antibody specific for 5-methylcytidine (5-mc) and to define the diagnosis potential of this marker.
  • 5-mc immunostaining scores were calculated in 17 papillary thyroid carcinomas (PTC), 6 follicular thyroid carcinomas (FTC), 16 follicular adenomas (FA), 19 nodular goiters (NG) and ten Hürthle cells adenomas (HCA).
  • Computerized image analysis showed a significant lower level of 5-mc immunostaining in thyroid carcinoma when compared with benign tumors or adjacent normal thyroid parenchyma (P<0.0001).
  • Overall, 5-mc accuracy to distinguish malign from benign thyroid tumors was similar to that of galectin-3 (89% versus 87%, P>0.05).
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. DNA Methylation. Goiter, Nodular / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Epigenesis, Genetic. Galectin 3 / analysis. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Reproducibility of Results

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  • [Cites] Gut. 2000 Nov;47(5):689-93 [11034586.001]
  • [Cites] Am J Clin Pathol. 2004 Oct;122(4):524-31 [15487449.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Feb;88(2):950; author reply 950-1 [12574240.001]
  • [Cites] Diagn Cytopathol. 1985 Apr-Jun;1(2):123-32 [3841772.001]
  • [Cites] Ann Surg. 2004 Sep;240(3):425-36; discussion 436-7 [15319714.001]
  • [Cites] Biotech Histochem. 2000 Nov;75(6):251-8 [11131565.001]
  • [Cites] Diagn Cytopathol. 2002 Jun;26(6):366-72 [12112826.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Oct;87(10):4806-10 [12364477.001]
  • [Cites] Endocr Pathol. 2003 Spring;14(1):55-60 [12746563.001]
  • [Cites] Int J Cancer. 2003 May 10;104(6):735-44 [12640681.001]
  • [Cites] Diagn Cytopathol. 2002 Jan;26(1):41-4 [11782086.001]
  • [Cites] Gut. 1996 Sep;39(3):434-8 [8949650.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2004 Jan;130(1):110-3 [14732779.001]
  • [Cites] Lancet. 2001 May 26;357(9269):1644-50 [11425367.001]
  • [Cites] Pol J Pathol. 2003;54(2):111-5 [14575419.001]
  • [Cites] Cancer Lett. 2003 Sep 10;199(1):69-73 [12963125.001]
  • [Cites] Mod Pathol. 2003 Nov;16(11):1117-23 [14614051.001]
  • [Cites] Histopathology. 2002 Sep;41(3):236-43 [12207785.001]
  • [Cites] Pathol Res Pract. 2003;199(6):399-404 [12924440.001]
  • [Cites] World J Surg. 2004 Nov;28(11):1115-21 [15490053.001]
  • [Cites] Endocr Pract. 2004 Jan-Feb;10(1):31-9 [15251619.001]
  • [Cites] Thyroid. 2001 Dec;11(12 ):1147-51 [12186502.001]
  • [Cites] Cancer Res. 2003 May 1;63(9):2316-21 [12727856.001]
  • [Cites] Zhonghua Bing Li Xue Za Zhi. 2004 Jun;33(3):212-6 [15256110.001]
  • [Cites] Rev Med Chil. 2003 Sep;131(9):965-72 [14635582.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jul;89(7):3214-23 [15240595.001]
  • [Cites] Cancer. 1999 Jan 1;85(1):112-8 [9921982.001]
  • [Cites] J Clin Endocrinol Metab. 1999 Jul;84(7):2449-57 [10404820.001]
  • [Cites] Ann Intern Med. 1993 Feb 15;118(4):282-9 [8420446.001]
  • [Cites] Endocrine. 2003 Nov;22(2):81-4 [14665710.001]
  • [Cites] Anticancer Res. 2004 May-Jun;24(3b):1993-7 [15274390.001]
  • [Cites] Virchows Arch. 2004 Apr;444(4):309-12 [14999471.001]
  • [Cites] Histopathology. 2004 Nov;45(5):493-500 [15500653.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Oct;87(10):4792-6 [12364475.001]
  • [Cites] Biomed Pharmacother. 2004 Jul-Aug;58(6-7):356-9 [15271416.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Nov;86(11):5152-8 [11701669.001]
  • [Cites] Anticancer Res. 2004 May-Jun;24(3a):1495-500 [15274315.001]
  • [Cites] J Clin Endocrinol Metab. 1993 Oct;77(4):991-5 [7691865.001]
  • [Cites] Virchows Arch. 2004 Aug;445(2):183-8 [15252732.001]
  • [Cites] Hum Pathol. 2001 Aug;32(8):856-62 [11521231.001]
  • [Cites] Thyroid. 2003 Apr;13(4):381-7 [12804106.001]
  • [Cites] J Endocrinol Invest. 2004 Apr;27(4):311-7 [15233548.001]
  • [Cites] Int J Mol Med. 2003 Oct;12(4):479-84 [12964023.001]
  • [Cites] J Clin Oncol. 1999 Nov;17(11):3494-502 [10550147.001]
  • [Cites] Biochem J. 1994 Mar 15;298 Pt 3:537-41 [8141765.001]
  • [Cites] Cancer Res. 2003 May 1;63(9):2312-5 [12727855.001]
  • [Cites] Semin Cancer Biol. 2004 Dec;14(6):427-32 [15489135.001]
  • (PMID = 15891902.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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66. Hur M, Yeo I, Park E, Kim YH, Yoo J, Kim E, No MH, Koh J, Kim S: Combination of statistical methods and Fourier transform ion cyclotron resonance mass spectrometry for more comprehensive, molecular-level interpretations of petroleum samples. Anal Chem; 2010 Jan 1;82(1):211-8
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  • Complex petroleum mass spectra obtained by Fourier-transform ion cyclotron resonance mass spectrometry (FTICR MS) were successfully interpreted at the molecular level by applying principle component analysis (PCA) and hierarchical clustering analysis (HCA).
  • Conventional data analyses would have been impractical with so much data.
  • HCA was also performed to group and compare samples based on selected peaks that had been grouped by PCA.
  • Subsequent heat map analyses revealed detailed compositional differences among grouped samples.
  • [MeSH-major] Cyclotrons. Fourier Analysis. Mass Spectrometry / methods. Petroleum / analysis

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  • (PMID = 19968292.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Petroleum
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67. Hillebrecht A, Klebe G: Use of 3D QSAR models for database screening: a feasibility study. J Chem Inf Model; 2008 Feb;48(2):384-96
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  • As model system isozymes of human carbonic anhydrase (hCA) are used, all results are exemplified studying affinity toward hCA II and selectivity between hCA I and II.

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  • (PMID = 18211050.001).
  • [ISSN] 1549-9596
  • [Journal-full-title] Journal of chemical information and modeling
  • [ISO-abbreviation] J Chem Inf Model
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II
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68. Kaakinen T, Alaoja H, Heikkinen J, Dahlbacka S, Laurila P, Kiviluoma K, Salomäki T, Tuominen H, Ohtonen P, Biancari F, Juvonen T: Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model. Ann Thorac Surg; 2006 Jan;81(1):183-90
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  • [Title] Hypertonic saline dextran improves outcome after hypothermic circulatory arrest: a study in a surviving porcine model.
  • In the present study we have assessed its potential neuroprotective efficacy in the setting of hypothermic circulatory arrest in a surviving porcine model.
  • METHODS: Twenty-four pigs were randomized to receive two 5-minute intravenous infusions (4 mL/kg) of either HSD (7.5 % saline, 6% dextran 70) or normal saline immediately after and 4 hours after a 75-minute period of hypothermic circulatory arrest at a brain temperature of 18 degrees C.
  • Intracranial pressure was lower in the HSD group from 45 minutes to 8 hours after hypothermic circulatory arrest (p = 0.03).
  • Cerebral perfusion pressure was higher in the HSD group from 45 minutes to 3 hours after hypothermic circulatory arrest (p = 0.06).
  • CONCLUSIONS: The use of HSD in experimental hypothermic circulatory arrest is associated with significantly better neurologic recovery, better histopathology, lower intracranial pressure, higher cerebral perfusion pressure, and better preservation of brain metabolism.
  • [MeSH-major] Circulatory Arrest, Deep Hypothermia Induced / adverse effects. Dextrans / therapeutic use. Hypoxia-Ischemia, Brain / etiology. Neuroprotective Agents / therapeutic use. Reperfusion Injury / prevention & control. Saline Solution, Hypertonic / therapeutic use. Sodium Chloride / therapeutic use
  • [MeSH-minor] Animals. Behavior, Animal / drug effects. Body Temperature. Brain / pathology. Brain Chemistry. Cardiopulmonary Bypass / adverse effects. Drug Administration Schedule. Drug Evaluation, Preclinical. Female. Glucose / analysis. Infusions, Intravenous. Intracranial Pressure / drug effects. Lactates / analysis. Oxygen / analysis. Partial Pressure. Pyruvates / analysis. Random Allocation. Sus scrofa

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  • [CommentIn] Ann Thorac Surg. 2006 Jan;81(1):190 [16368361.001]
  • (PMID = 16368360.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Lactates; 0 / Neuroprotective Agents; 0 / Pyruvates; 0 / Saline Solution, Hypertonic; 0 / hypertonic saline-dextran solution; 451W47IQ8X / Sodium Chloride; IY9XDZ35W2 / Glucose; K3R6ZDH4DU / Dextrans; S88TT14065 / Oxygen
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69. Liu ZG, Sun LZ, Chang Q, Zhu JM, Dong C, Yu CT, Liu YM, Zhang HT: Should the "elephant trunk" be skeletonized? Total arch replacement combined with stented elephant trunk implantation for Stanford type A aortic dissection. J Thorac Cardiovasc Surg; 2006 Jan;131(1):107-13
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  • The stented graft, a 10-cm-long woven Dacron graft with a self-expandable stent, was implanted through the aortic arch during hypothermic circulatory arrest.
  • RESULTS: Cardiopulmonary bypass time was 166 +/- 38 minutes, and average selective cerebral perfusion and lower body arrest time was 30 +/- 15 minutes.
  • [MeSH-minor] Acute Disease. Adult. Aged. Cardiopulmonary Bypass. Chronic Disease. Female. Humans. Male. Middle Aged. Vascular Surgical Procedures / methods

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  • (PMID = 16399301.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Pele LC, Thoree V, Mustafa F, He S, Tsaprouni L, Punchard NA, Thompson RP, Evans SM, Powell JJ: Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis. J Nutr; 2007 Nov;137(11):2475-80
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  • [Title] Low dietary calcium levels modulate mucosal caspase expression and increase disease activity in mice with dextran sulfate sodium induced colitis.
  • BALB/c mice received a normal Ca (NCa) diet (0.5% Ca), a high Ca (HCa) diet (1.5% Ca), a low Ca (LCa) diet (0.05% Ca), or a very low Ca (VLCa) diet (0.009% Ca) for 3 wk.
  • Half of the mice in each group received DSS (1.5%) for 20 d in their drinking water, and disease activity was assessed.
  • DSS-induced disease activity was higher in mice fed low dietary Ca levels [P < 0.0001, VLCa and DSS vs. NCa and DSS (NCaDSS) and P < 0.005, LCa and DSS vs. NCaDSS], and mice from the VLCa group were moribund within 11 d of DSS administration.
  • Those in the HCa group did not differ greatly from controls.
  • [MeSH-minor] Animals. Dextran Sulfate. Disease Models, Animal. Female. Inflammation. Mice. Mice, Inbred BALB C

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  • (PMID = 17951488.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105960399
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary; 9042-14-2 / Dextran Sulfate; EC 3.4.22.- / Caspases; SY7Q814VUP / Calcium
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71. Micchelli ST, Vivekanandan P, Boitnott JK, Pawlik TM, Choti MA, Torbenson M: Malignant transformation of hepatic adenomas. Mod Pathol; 2008 Apr;21(4):491-7
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  • [Title] Malignant transformation of hepatic adenomas.
  • Hepatic adenomas are benign neoplasms of the liver that occur in several well-defined clinical settings, but principally that of excess hormone exposure.
  • The clinical presentation and pathological findings were reviewed for all hepatic adenomas resected between January 1, 2003 and July 1, 2006.
  • A total of 17 hepatic adenomas were resected and 3 showed malignant transformation.
  • Histologically, the malignant transformation occurred within otherwise typical hepatic adenomas.
  • Two of three cases showed patchy atypia throughout the hepatic adenoma.
  • The hepatocellular carcinoma arose as distinct nodules directly within the adenomas, effectively ruling out synchronous lesions.
  • The hepatocellular carcinomas were unifocal in two cases and multifocal in one case with the greatest dimensions of the hepatocellular carcinoma being 2.5, 2.2, and 1 cm.
  • Immunostains for AFP and beta-catenin were negative in both the hepatic adenomas and areas of hepatocellular carcinoma. p53 immunostaining was positive within the areas of malignant transformation in one case.
  • No mutations or deletions were seen in exon 3 of the beta-catenin gene for either the adenomas or the carcinoma.
  • In conclusion, two of the cases that developed hepatocellular carcinomas showed cytological atypia in the background adenoma.
  • The hepatocellular carcinomas arose as distinct nodules within the adenomas.
  • No common molecular pathway of hepatocellular carcinogenesis was observed by examining AFP, beta-catenin, and p53 immunostains and no beta-catenin mutations or deletions were found.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Carcinoma, Hepatocellular / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology

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  • (PMID = 18246041.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal; 0 / Tumor Suppressor Protein p53; 0 / alpha-Fetoproteins; 0 / beta Catenin
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72. Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ: Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis; 2007 May;28(5):940-6
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  • Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic BAs and an increase in BA pool size.
  • Surprisingly, at 12 months of age, male and female Fxr-null mice had a high incidence of degenerative hepatic lesions, altered cell foci and liver tumors including hepatocellular adenoma, carcinoma and hepatocholangiocellular carcinoma, the latter of which is rarely observed in mice.
  • They also had increased cell proliferation as revealed by increased PCNA mRNA and BrdU incorporation.


73. Colovic R, Grubor N, Micev M, Radak V: Hepatocellular adenoma with malignant alteration. Hepatogastroenterology; 2007 Mar;54(74):386-8
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  • [Title] Hepatocellular adenoma with malignant alteration.
  • Hepatocellular adenoma is a rare benign tumor of the liver which appears almost exclusively in women taking oral contraceptives.
  • With ultrasonography and CT scan a solitary well demarcated mass within the right liver of otherwise normal appearance was diagnosed.
  • During an open surgery a solitary, unilobular, spherical, well demarcated tumor on the lower surface of the segments IVb, V and VI of the liver, 115 x 100 x 90 mm in diameter was excised.
  • The histology revealed a hepatocellular adenoma with malignant alteration.
  • The patient is the eldest presented case of malignant alteration of hepatocellular adenoma who had never taken oral contraceptives or other hormones.
  • [MeSH-major] Adenoma, Liver Cell / pathology. Cell Transformation, Neoplastic / pathology. Liver Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hepatectomy. Humans. Liver / pathology. Risk Factors. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 17523280.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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74. Santoro L, Grazioli L, Filippone A, Grassedonio E, Belli G, Colagrande S: Resovist enhanced MR imaging of the liver: does quantitative assessment help in focal lesion classification and characterization? J Magn Reson Imaging; 2009 Nov;30(5):1012-20
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  • [Title] Resovist enhanced MR imaging of the liver: does quantitative assessment help in focal lesion classification and characterization?
  • PURPOSE: To improve characterization of focal liver lesions by a prospective quantitative analysis of percentage signal intensity change, in dynamic and late phases after slow (0.5 mL/s) Resovist administration.
  • RESULTS: The enhancement obtained on dynamic study is more suitable in hemangiomas and focal nodular hyperplasias than in adenomas and hepatocellular carcinomas.
  • To discriminate benign versus malignant lesions on late-phase-T2-weighted images, a cutoff = -26%, allowed sensitivity and specificity values of 97.4% and 97.7%, respectively.
  • To differentiate hemangioma versus all other focal liver lesions, on late-phase-T1-weighted images, a cutoff = +40% permitted sensitivity and specificity values of 90.5% and 98.0%, respectively.
  • CONCLUSION: Late phase quantitative evaluation after slow Resovist administration, allows to differentiate malignant from benign hepatic masses and hemangiomas from all the others focal liver lesions, on T2-/T1-weighted acquisitions, respectively. J
  • [MeSH-major] Ferric Compounds / pharmacology. Ferrosoferric Oxide / pharmacology. Image Processing, Computer-Assisted / methods. Liver / pathology. Magnetic Resonance Imaging / methods

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  • (PMID = 19856433.001).
  • [ISSN] 1522-2586
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 0 / Magnetite Nanoparticles; 1K09F3G675 / ferric oxide; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
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75. Abdo MR, Vullo D, Saada MC, Montero JL, Scozzafava A, Winum JY, Supuran CT: Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives. Bioorg Med Chem Lett; 2009 May 1;19(9):2440-3
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  • The compounds showed a weak hCA I activation profile, but were more efficient as hCA II and IX activators.
  • The 4-iodophenyl-substituted derivative behaved as a strong and isozyme selective hCA II activator, with an activation constant of 0.21muM.

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  • (PMID = 19345095.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Protein Isoforms; 0 / Recombinant Proteins; 0 / phenylsulfonylhydrazido l-histidine; 4QD397987E / Histidine; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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76. Sinha R, Peters U, Cross AJ, Kulldorff M, Weissfeld JL, Pinsky PF, Rothman N, Hayes RB: Meat, meat cooking methods and preservation, and risk for colorectal adenoma. Cancer Res; 2005 Sep 1;65(17):8034-41
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  • [Title] Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
  • Cooking meat at high temperatures produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs).
  • Meat intake may increase cancer risk as HCAs, PAHs, and N-nitroso compounds are carcinogenic in animal models.
  • We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls.
  • The questionnaire was linked to a previously developed database to determine exposure to HCAs and PAHs.
  • Intake of red meat, with known doneness/cooking methods, was associated with an increased risk of adenoma in the descending and sigmoid colon [odds ratio (OR), 1.26; 95% confidence interval (95% CI), 1.05-1.50 comparing extreme quintiles of intake] but not rectal adenoma.
  • Well-done red meat was associated with increased risk of colorectal adenoma (OR, 1.21; 95% CI, 1.06-1.37).
  • Increased risks for adenoma of the descending colon and sigmoid colon were observed for the two HCAs: 2-amino-3,8-dimethylimidazo[4,5]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine (OR, 1.18; 95% CI, 1.01-1.38 and OR, 1.17, 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35).
  • Greater intake of bacon and sausage was associated with increased colorectal adenoma risk (OR, 1.14; 95% CI, 1.00-1.30); however, total intake of processed meat was not (OR, 1.04; 95% CI, 0.90-1.19).
  • Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma.
  • [MeSH-major] Adenoma / etiology. Colorectal Neoplasms / etiology. Cooking. Food Preservation. Meat

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  • (PMID = 16140978.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Mutagens; 0 / Quinoxalines; 3417WMA06D / Benzo(a)pyrene; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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77. Osborne-Bossert C, Fitzgerald D, Speir A, St Onge J: Delivery of antegrade cerebral perfusion during descending aortic reconstruction: a case report. Perfusion; 2008 Mar;23(2):135-7
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  • Antegrade cerebral perfusion (ACP) has been demonstrated to be a safe and effective method of providing adequate protection to the brain during hypothermic circulatory arrest.
  • By improving oxygen delivery to the cerebral capillaries, users of this technique have reported fewer temporary neurological deficits in postoperative periods, even after prolonged periods of circulatory arrest.
  • Surgical correction of a descending aortic aneurysm can provide a challenge when the left subclavian artery is involved.
  • A period of hypothermic circulatory arrest is required to complete the proximal anastamosis of the graft.
  • A 54-year-old female presented with a computerized tomography (CT) scan of a descending aortic aneurysm, originating at the base of the left subclavian artery.

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  • (PMID = 18840584.001).
  • [ISSN] 0267-6591
  • [Journal-full-title] Perfusion
  • [ISO-abbreviation] Perfusion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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78. Rhodes MC, Bucher JR, Peckham JC, Kissling GE, Hejtmancik MR, Chhabra RS: Carcinogenesis studies of benzophenone in rats and mice. Food Chem Toxicol; 2007 May;45(5):843-51
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  • There was a positive trend in the incidence of renal tubule adenoma in male rats; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Increased incidences of mononuclear cell leukemia were observed in male rats exposed to 312 or 625 ppm benzophenone and in female rats exposed to 625 ppm benzophenone.
  • Liver lesions observed included significantly increased incidences of hepatocytic centrilobular hypertrophy in all exposed groups of rats.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1250 ppm groups.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma.
  • There was equivocal evidence of carcinogenic activity of benzophenone in female F344/N rats based on the marginal increased incidences of mononuclear cell leukemia and histiocytic sarcoma.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F(1) mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F(1) mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F(1) mice may have been related to benzophenone exposure.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Animals. Dose-Response Relationship, Drug. Female. Histiocytic Disorders, Malignant / chemically induced. Histiocytic Disorders, Malignant / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia / chemically induced. Leukemia / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Rats. Rats, Inbred F344. Sarcoma / chemically induced. Sarcoma / pathology. Sex Factors

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  • [Cites] J Am Acad Dermatol. 2003 Nov;49(5 Suppl):S259-61 [14576646.001]
  • [Cites] Toxic Rep Ser. 2000 Apr;(61):1-53, A1-13 [11803700.001]
  • [Cites] Biometrics. 1971 Mar;27(1):103-17 [5547548.001]
  • [Cites] Biometrics. 1972 Jun;28(2):519-31 [5037867.001]
  • [Cites] Biometrics. 1988 Jun;44(2):417-31 [3390507.001]
  • [Cites] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275.001]
  • [Cites] Ren Fail. 1991;13(4):211-25 [1780490.001]
  • [Cites] Toxicol Pathol. 1993;21(2):206-18 [8210943.001]
  • [Cites] Environ Health Perspect. 1993 Dec;101 Suppl 5:115-20 [7516872.001]
  • [Cites] Toxicol Pathol. 1994 Sep-Oct;22(5):457-72 [7899775.001]
  • [Cites] Toxicol Pathol. 1997 May-Jun;25(3):256-63 [9210256.001]
  • [Cites] Toxicol Pathol. 1999 Jul-Aug;27(4):383-94 [10485818.001]
  • [Cites] Toxicol Pathol. 1998 Jan-Feb;26(1):104-12 [9502392.001]
  • [Cites] Contact Dermatitis. 2001 Mar;44(3):188 [11217999.001]
  • [Cites] Toxicol Pathol. 2002 Nov-Dec;30(6):681-6 [12512869.001]
  • [Cites] Australas J Dermatol. 2001 Nov;42(4):257-9 [11903157.001]
  • [Cites] Bioorg Med Chem. 2004 May 15;12(10):2759-72 [15110857.001]
  • (PMID = 17187913.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
  • [Other-IDs] NLM/ NIHMS21944; NLM/ PMC1936973
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79. Apostolakis EE, Baikoussis NG, Katsanos K, Karanikolas M: Postoperative peri-axillary seroma following axillary artery cannulation for surgical treatment of acute type A aortic dissection. J Cardiothorac Surg; 2010;5:43
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  • Right axillary artery cannulation confers significant advantages, because it provides antegrade arterial perfusion during cardiopulmonary bypass, and allows continuous antegrade cerebral perfusion during hypothermic circulatory arrest, thereby minimizing global cerebral ischemia.
  • We herein present the case of a 36-year-old Caucasian man with known Marfan syndrome and acute type A aortic dissection, who had direct right axillary artery cannulation for surgery of the ascending aorta.

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  • [Cites] J Vasc Surg. 1999 Dec;30(6):1077-83 [10587392.001]
  • [Cites] J Thorac Cardiovasc Surg. 2009 Nov;138(5):1081-9 [19758609.001]
  • [Cites] AJR Am J Roentgenol. 2002 Jun;178(6):1462-4 [12034619.001]
  • [Cites] Ann Thorac Surg. 2004 Apr;77(4):1315-20 [15063259.001]
  • [Cites] Ann Thorac Surg. 2004 Jul;78(1):103-8; discussion 103-8 [15223412.001]
  • [Cites] Surg Today. 2004;34(8):698-700 [15290402.001]
  • [Cites] Ann Thorac Surg. 2004 Oct;78(4):1274-84; discussion 1274-84 [15464485.001]
  • [Cites] Ann Thorac Surg. 2004 Oct;78(4):1285-9; discussion 1285-9 [15464486.001]
  • [Cites] Am J Surg. 1985 May;149(5):587-90 [3993835.001]
  • [Cites] Eur J Cardiothorac Surg. 2005 Apr;27(4):634-7 [15784364.001]
  • [Cites] J Am Coll Surg. 2006 Oct;203(4):506-11 [17000394.001]
  • [Cites] Ann Thorac Surg. 2007 Mar;83(3):1219-24 [17307506.001]
  • [Cites] Ann Thorac Cardiovasc Surg. 2008 Jun;14(3):138-48 [18577891.001]
  • [Cites] Ann Vasc Surg. 2009 Jan-Feb;23(1):144-6 [18502606.001]
  • [Cites] J Thorac Cardiovasc Surg. 2009 Jan;137(1):242-3 [19154932.001]
  • [Cites] J Trauma. 2009 Apr;66(4):E52-4 [18277269.001]
  • [Cites] J Thorac Cardiovasc Surg. 2009 Jul;138(1):251; author reply 251-2 [19577095.001]
  • [Cites] Eur J Vasc Endovasc Surg. 2001 Nov;22(5):469-71 [11735188.001]
  • (PMID = 20500837.001).
  • [ISSN] 1749-8090
  • [Journal-full-title] Journal of cardiothoracic surgery
  • [ISO-abbreviation] J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2880968
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80. Kouchoukos NT, Masetti P, Mauney MC, Murphy MC, Castner CF: One-stage repair of extensive chronic aortic dissection using the arch-first technique and bilateral anterior thoracotomy. Ann Thorac Surg; 2008 Nov;86(5):1502-9
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  • METHODS: Fifty-one patients with chronic expanding thoracic aortic dissections (48 type A, 3 type B with proximal extension) were treated with a single procedure using a bilateral anterior thoracotomy, hypothermic circulatory arrest, and reperfusion of the arch vessels first to minimize brain ischemia.
  • Forty-six patients had previous operations: for acute type A aortic dissection (n = 36), aortic valve disease (n = 6), or coronary artery disease (n = 4).
  • CONCLUSIONS: The technique is a safe and suitable alternative to the two-stage (elephant trunk technique) and hybrid procedures for treatment of chronic dissection with aneurysm of the thoracic aorta.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chronic Disease. Humans. Middle Aged. Recurrence. Reoperation. Survival Rate

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  • [CommentIn] Ann Thorac Surg. 2008 Nov;86(5):1509 [19049740.001]
  • (PMID = 19049739.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
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81. Ambrosi DJ, Tanasijevic B, Kaur A, Obergfell C, O'Neill RJ, Krueger W, Rasmussen TP: Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells. Stem Cells; 2007 May;25(5):1104-13
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  • [Title] Genome-wide reprogramming in hybrids of somatic cells and embryonic stem cells.
  • The resulting hybrids are pluripotent as judged by developmental assays, but detailed analyses of the underlying molecular-genetic control of reprogrammed transcription in such hybrids are required to better understand fusion-mediated reprogramming.
  • Comprehensive analysis of the mouse embryonic fibroblast/ESC hybrid transcriptome revealed global patterns of gene expression reminiscent of ESCs.
  • However, combined analysis of variance and hierarchical clustering analyses revealed at least seven distinct classes of differentially regulated genes in comparisons of hybrids, ESCs, and somatic cells.
  • Somatic/ESC hybrid cell lines resemble their pre-fusion ESC partners in terms of behavior in culture and pluripotency.
  • [MeSH-major] Cellular Reprogramming / genetics. Chimera / genetics. Embryonic Stem Cells / metabolism. Genome
  • [MeSH-minor] Alleles. Animals. Base Sequence. Cell Line. Chromosomes, Mammalian / genetics. Cluster Analysis. DNA Mutational Analysis. Gene Expression Profiling. Gene Expression Regulation, Developmental. Karyotyping. Mice. Molecular Sequence Data. Pluripotent Stem Cells / metabolism. Transcription, Genetic

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  • (PMID = 17272499.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01AG23687
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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82. Baraki H, Hagl C, Khaladj N, Kallenbach K, Weidemann J, Haverich A, Karck M: The frozen elephant trunk technique for treatment of thoracic aortic aneurysms. Ann Thorac Surg; 2007 Feb;83(2):S819-23; discussion S824-31
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  • BACKGROUND: The frozen elephant trunk technique allows for single-stage repair of combined aortic arch and descending aortic aneurysms using a hybrid prosthesis with a stented and a nonstented end.
  • The stented end of the hybrid prosthesis was placed through the opened aortic arch under fluoroscopic control using hypothermic circulatory arrest and selective antegrade cerebral perfusion.
  • In 1 patient, the descending aorta was perforated owing to misplacement of the stented end of the hybrid prosthesis.

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  • (PMID = 17257934.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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83. Horiuchi S, Kumai R, Tokunaga Y, Tokura Y: Proton dynamics and room-temperature ferroelectricity in anilate salts with a proton sponge. J Am Chem Soc; 2008 Oct 8;130(40):13382-91
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  • Dielectric measurements revealed phase transitions at T(c) = 334 and 172 K for bromanilate (Hba(-)) and chloranilate (Hca(-)) salts, respectively.

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  • (PMID = 18781747.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Xie C, Mace J, Dinno MA, Li YQ, Tang W, Newton RJ, Gemperline PJ: Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy. Anal Chem; 2005 Jul 15;77(14):4390-7
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  • [Title] Identification of single bacterial cells in aqueous solution using confocal laser tweezers Raman spectroscopy.
  • We report on a rapid method for reagentless identification and discrimination of single bacterial cells in aqueous solutions using a combination of laser tweezers and confocal Raman spectroscopy (LTRS).
  • The optical trapping enables capturing of individual bacteria in aqueous solution in the focus of the laser beam and levitating the captured cell well off the cover plate, thus maximizing the excitation and collection of Raman scattering from the cell and minimizing the unwanted background from the cover plate and environment.
  • Raman spectral patterns excited by a near-infrared laser beam provide intrinsic molecular information for reagentless analysis of the optically isolated bacterium.
  • We show that synchronized bacterial cells can be well-discriminated among the six species using principal component analyses (PCA).
  • Unsynchronized bacterial cells that are cultured at stationary phases can also be well-discriminated by the PCA, as well as by a hierarchical cluster analysis (HCA) of their Raman spectra.
  • We also show that unsynchronized bacteria selected from random growth phases can be classified with the help of a generalized discriminant analysis (GDA).
  • These findings demonstrate that the LTRS may find valuable applications in rapid sensing of microbial cells in diverse aqueous media.
  • [MeSH-major] Bacteria / cytology. Optical Tweezers. Spectrum Analysis, Raman / instrumentation. Spectrum Analysis, Raman / methods

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  • (PMID = 16013851.001).
  • [ISSN] 0003-2700
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Solutions
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85. Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett; 2005 May 2;15(9):2359-64
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  • A series of such aromatic sulfonamides incorporating thioureido-sulfanilyl moieties has been prepared and investigated for its interaction with the catalytic domain of the human isozyme hCA IX.
  • Due to the highest expression of CA IX in clear renal cell carcinoma and its chemo/radioresistance, our efforts are first of all directed to generate effective therapeutic strategies for the cure of this malignancy.

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  • (PMID = 15837325.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Carbonic Anhydrase Inhibitors; 0 / Sulfonamides; 8W8T17847W / Urea; EC 4.2.1.- / Carbonic Anhydrase I; EC 4.2.1.- / Carbonic Anhydrase II; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
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86. Réti A, Barna G, Pap E, Adleff V, L Komlósi V, Jeney A, Kralovánszky J, Budai B: Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. Pathol Oncol Res; 2009 Sep;15(3):335-44
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  • [Title] Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells.
  • The antiproliferative effect of 5-fluorouracil (5-FU) in the presence of low dose non-steroidal anti-inflammatory drugs (NSAIDs) on high cyclooxygenase-2 (COX-2)-expressing HCA-7 and low COX-2-expressing HT-29 colon carcinoma cell lines was investigated.
  • Pharmacogenetic parameters were studied to characterize the 5-FU sensitivity of the two cell lines.
  • Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms were determined by PCR analysis.
  • Cell proliferation was measured by SRB assay, cell cycle distribution and apoptosis by FACS analysis.
  • The HT-29 cell line was found to be homozygous for TS 2R and 1494ins6 and T homozygous for MTHFR 677 polymorphisms predicting high 5-FU sensitivity (IC(50): 10 microM).
  • TS 3R homozygosity, TS 1496del6 and MTHFR 677CT heterozygosity may explain the modest 5-FU sensitivity (IC(50): 1.1 mM) of the HCA-7 cell line.
  • Indomethacin and NS-398 (10 microM and 1.77 microM, respectively) reduced the PGE(2) level in HCA-7 cells (>90%).
  • Low concentrations of NSAIDs without antiproliferative potency increased the S-phase arrest and enhanced the cytotoxic action of 5-FU only in HCA-7 cells after 48-hours treatment.
  • The presented data suggested that the enhancement of 5-FU cytotoxicity by indomethacin or NS-398 applied in low dose is related to the potency of NSAIDs to modulate the cell-cycle distribution and the apoptosis; however, it seems that this effect might be dependent on cell phenotype, namely on the COX-2 expression.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Cell Proliferation / drug effects. Cyclooxygenase 2 / metabolism. Cyclooxygenase Inhibitors / pharmacology. Fluorouracil / pharmacology
  • [MeSH-minor] Apoptosis / drug effects. Blotting, Western. Cell Line, Tumor. Cell Separation. Enzyme-Linked Immunosorbent Assay. Flow Cytometry. HT29 Cells. Humans. Indomethacin / pharmacology. Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics. Microscopy, Fluorescence. Nitrobenzenes / pharmacology. Polymorphism, Genetic. Reverse Transcriptase Polymerase Chain Reaction. Sulfonamides / pharmacology. Thymidylate Synthase / genetics

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  • [Cites] Clin Cancer Res. 2000 Nov;6(11):4432-41 [11106264.001]
  • [Cites] Cell Prolif. 2008 Apr;41(2):230-47 [18336469.001]
  • [Cites] Eur J Cancer. 1994;30A(10):1517-22 [7833111.001]
  • [Cites] Tohoku J Exp Med. 1997 Mar;181(3):361-70 [9163851.001]
  • [Cites] Eur J Cancer. 1998 Jul;34(8):1250-9 [9849488.001]
  • [Cites] Oncogene. 2003 Sep 11;22(39):8021-30 [12970750.001]
  • [Cites] Clin Cancer Res. 2003 May;9(5):1885-97 [12738747.001]
  • [Cites] Clin Cancer Res. 2007 Feb 1;13(3):1036-44 [17289900.001]
  • [Cites] Lung Cancer. 2003 Apr;40(1):33-44 [12660005.001]
  • [Cites] Anticancer Drugs. 1999 Jul;10(6):561-7 [10885904.001]
  • [Cites] Mech Ageing Dev. 2004 May;125(5):359-66 [15130753.001]
  • [Cites] Neoplasia. 2000 Jul-Aug;2(4):346-56 [11005569.001]
  • [Cites] Mol Pharmacol. 2005 Feb;67(2):545-57 [15537867.001]
  • [Cites] J Cancer Res Clin Oncol. 1999 Dec;125(12):675-84 [10592100.001]
  • [Cites] Cancer Treat Rev. 2001 Feb;27(1):51-61 [11237777.001]
  • [Cites] Biochim Biophys Acta. 1994 Nov 16;1209(1):130-9 [7947975.001]
  • [Cites] Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:187-96 [12432918.001]
  • [Cites] Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):976-81 [16418264.001]
  • [Cites] Leuk Lymphoma. 2005 Mar;46(3):425-33 [15621834.001]
  • [Cites] Biochim Biophys Acta. 2000 Mar 27;1470(2):M69-78 [10722929.001]
  • [Cites] Nat Genet. 1995 May;10(1):111-3 [7647779.001]
  • [Cites] Pharmacol Ther. 1991;50(3):367-424 [1721719.001]
  • [Cites] J Pharmacol Exp Ther. 2001 Sep;298(3):976-85 [11504793.001]
  • [Cites] J Urol. 2002 Dec;168(6):2650-4 [12442003.001]
  • [Cites] Mol Cancer Ther. 2007 Jan;6(1):122-7 [17237272.001]
  • [Cites] Br J Cancer. 2008 Aug 5;99(3):502-12 [18648368.001]
  • [Cites] Int J Clin Oncol. 2001 Apr;6(2):84-9 [11706755.001]
  • [Cites] Eur J Cancer. 2002 Aug;38(12):1661-70 [12142058.001]
  • [Cites] Proc Natl Acad Sci U S A. 1990 Oct;87(19):7555-9 [1699228.001]
  • [Cites] J Biol Chem. 2002 Jul 19;277(29):26012-20 [11980903.001]
  • [Cites] Br J Cancer. 2004 Jan 26;90(2):526-34 [14735204.001]
  • [Cites] Urology. 2005 Aug;66(2):434-40 [16098373.001]
  • [Cites] Cancer Res. 2003 Oct 15;63(20):6726-34 [14583467.001]
  • [Cites] Cancer Lett. 2004 Nov 8;215(1):1-20 [15374627.001]
  • [Cites] Eur J Pharmacol. 2007 Jun 1;563(1-3):49-60 [17341418.001]
  • [Cites] Pharmacogenet Genomics. 2005 Oct;15(10):723-30 [16141798.001]
  • [Cites] Dig Dis Sci. 2008 Aug;53(8):2195-203 [18320325.001]
  • [Cites] Oncogene. 2008 May 8;27(21):3032-44 [18071320.001]
  • [Cites] Br J Pharmacol. 1987 May;91(1):229-35 [3594078.001]
  • [Cites] J Biol Chem. 1993 Mar 25;268(9):6610-4 [8454631.001]
  • [Cites] J Biol Chem. 2000 Oct 27;275(43):33951-6 [10930401.001]
  • [Cites] Br J Cancer. 2006 Feb 13;94(3):346-50 [16421592.001]
  • [Cites] Cancer Lett. 2001 Mar 10;164(1):77-84 [11166918.001]
  • (PMID = 19048402.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclooxygenase Inhibitors; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.5.1.5 / Methylenetetrahydrofolate Dehydrogenase (NADP); EC 2.1.1.45 / Thymidylate Synthase; U3P01618RT / Fluorouracil; XXE1CET956 / Indomethacin
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87. Papanikolaou V, Giakoustidis D, Patsiaura K, Imvrios G, Antoniadis N, Ouzounidis N, Nikopolitidis V, Antoniadis A, Takoudas D: Management of a giant ruptured hepatocellular adenoma. Report of a case. Hippokratia; 2007 Apr;11(2):86-8
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  • [Title] Management of a giant ruptured hepatocellular adenoma. Report of a case.
  • This report describes a rare case of a young woman with massive intra-abdominal bleeding due to a giant ruptured hepatocellular adenoma.
  • The patient had never used oral contraceptive pills and she was urgently operated for haemorrhage control in another hospital where the left hepatic artery was also ligated.
  • After haemodynamic stabilization in the ICU and because of a complicated postoperative course (signs of intraabdominal sepsis) she was transferred to our hospital and a left lobectomy was performed.
  • We present the case and comment on the preferred treatment modalities of hepatocellular adenomas.

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  • [Cites] Ceylon Med J. 1997 Mar;42(1):42-3 [9164033.001]
  • [Cites] Liver Transpl Surg. 1995 Mar;1(2):99-102 [9346548.001]
  • [Cites] AJR Am J Roentgenol. 1995 Dec;165(6):1426 [7484578.001]
  • [Cites] Arch Surg. 1994 Jul;129(7):712-7 [7517661.001]
  • [Cites] Br J Surg. 1993 Mar;80(3):380-3 [8472159.001]
  • [Cites] Br J Surg. 2001 Feb;88(2):207-9 [11167868.001]
  • [Cites] Ann Intern Med. 1989 Mar 15;110(6):489-90 [2537593.001]
  • [Cites] Ann Intern Med. 1986 Oct;105(4):547-9 [3019201.001]
  • [Cites] Lancet. 1980 Feb 9;1(8163):273-6 [6101735.001]
  • [Cites] Dig Surg. 2002;19(2):109-13 [11978996.001]
  • [Cites] Surg Gynecol Obstet. 1991 Nov;173(5):426-31 [1658955.001]
  • (PMID = 19582184.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2464268
  • [Keywords] NOTNLM ; adenoma / giant / hepatocellular / rupture / surgical
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88. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT: Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. J Med Chem; 2005 Dec 1;48(24):7860-6
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  • A lately discovered carbonic anhydrase (hCA, EC 4.2.1.1), the mitochondrial hCA VB, was cloned, expressed, and purified.
  • Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a catalyst for the physiological reaction, with kcat = 9.5 x 10(5) s(-1) and kcat/K(M) = 9.8 x 10(7) M(-1) s(-1), being second only to hCA II among the 16 isoforms presently known in humans.
  • We investigated the inhibition of hCA VB with a library of sulfonamides/sulfamates, some of which are clinically used compounds.
  • Benzenesulfonamides were ineffective inhibitors, whereas derivatives bearing 4-amino, 4-hydrazino, 4-methyl, 4-carboxy moieties or halogenated sulfanilamides were more effective (Ki's of 1.56-4.3 microM).
  • Among the 10 clinically used compounds, acetazolamide, benzolamide, topiramate, and indisulam showed effective inhibitory activity (Ki's of 18-62 nM).
  • Three compounds showed better activity against hCA VB over hCA II, among which were sulpiride and ethoxzolamide, which were 2 times more effective inhibitors of the mitochondrial over the cytosolic isozyme. hCA VB is a druggable target and some of its inhibitors may lead to the development of novel antiobesity therapies.

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  • (PMID = 16302824.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbonic Anhydrase Inhibitors; 0 / Isoenzymes; 0 / Sulfonamides; 0 / Sulfonic Acids; 9NFU33906Q / sulfamic acid; EC 4.2.1.- / Carbonic Anhydrase V
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89. Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Sep;(560):1, 7-31,33-171 passim
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  • Genetic toxicology studies were conducted in Salmonella typhimurium, Escherichia coli, rat bone marrow cells, and mouse peripheral blood erythrocytes.
  • The incidences of mononuclear cell leukemia were significantly increased in 20 and 50 mg/kg females and significantly decreased in 20 and 50 mg/kg males.
  • Incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) were significantly increased in 20 mg/kg males.
  • The incidence of testicular interstitial cell adenoma (including bilateral) was significantly decreased in 50 mg/kg males.
  • In the liver of males, the incidences of basophilic focus in all dosed groups, the incidence of clear cell focus in the 20 mg/kg group, and the incidence of eosinophilic focus in the 50 mg/kg group were significantly increased.
  • The incidences of hepatocellular adenoma in males and females were significantly increased in the 50 mg/kg groups.
  • In females, the incidences of hepatocellular carcinoma were significantly increased in all dosed groups.
  • Incidences of hepatocellular adenoma or carcinoma (combined) in males and females were significantly increased in the 50 mg/kg groups.
  • Incidences of multiple hepatocellular adenomas and carcinomas were significantly increased in 10 and 50 mg/kg males, and there was an increased incidence of multiple hepatocellular adenomas in 50 mg/kg females.
  • The incidence of eosinophilic focus was significantly increased in 50 mg/kg males, and the incidences of mixed cell focus and cytoplasmic vacuolization were significantly increased in 50 mg/kg females.
  • There was a marginally increased incidence of pancreatic islet adenoma in 50 mg/kg males and in 10 and 50 mg/kg females, with an earlier day of first incidence in males.
  • GENETIC TOXICOLOGY: androstenedione was not mutagenic in either of two independent bacterial mutation assays conducted with and without exogenous metabolic activation.
  • Results of a peripheral blood erythrocyte micronucleus test in mice, in which androstenedione was administered by gavage for 3 months, were negative in males but judged to be equivocal in females due to a small increase (twofold over background) in micronucleated normochromatic erythrocytes observed at the highest dose administered (50 mg/kg).
  • CONCLUSIONS: under the conditions of these 2-year gavage studies, there was equivocal evidence of carcinogenic activity of androstenedione in male F344/N rats based on increased incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined).
  • There was equivocal evidence of carcinogenic activity of androstenedione in female F344/N rats based on increased incidences of mononuclear cell leukemia.
  • There was clear evidence of carcinogenic activity of androstenedione in male B6C3F1 mice based on increased incidences of multiple hepatocellular adenoma and hepatocellular carcinoma and increased incidence of hepatoblastoma.
  • There was clear evidence of carcinogenic activity of androstenedione in female B6C3F1 mice based on increased incidences of hepatocellular adenoma and hepatocellular carcinoma.
  • Increased incidences of pancreatic islet adenoma in male and female mice were also considered chemical related.
  • Androstenedione administration caused increased incidences in nonneoplastic lesions of the liver in male and female rats and mice; pancreatic islets and exocrine pancreas of female rats; and clitoral gland, kidney, and submandibular salivary gland of female mice.
  • Decreases in the incidences of testicular interstitial cell adenoma in male rats, mammary gland fibroadenoma, cysts, and hyperplasia in female rats, and malignant lymphoma in female mice were considered related to androstenedione administration.
  • [MeSH-minor] Animal Feed. Animals. Biomarkers. Body Weight / drug effects. Carcinogenicity Tests. Chemistry, Pharmaceutical. Dose-Response Relationship, Drug. Drug-Induced Liver Injury / metabolism. Drug-Induced Liver Injury / pathology. Estrous Cycle. Female. Genitalia / drug effects. Intubation, Gastrointestinal. Male. Mice. Mice, Inbred Strains. Micronucleus Tests. Mutagens / toxicity. Organ Size / drug effects. Rats. Rats, Inbred F344

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  • (PMID = 21037592.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Review; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Mutagens; 409J2J96VR / Androstenedione
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90. Reddy SK, Kishnani PS, Sullivan JA, Koeberl DD, Desai DM, Skinner MA, Rice HE, Clary BM: Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia. J Hepatol; 2007 Nov;47(5):658-63
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  • [Title] Resection of hepatocellular adenoma in patients with glycogen storage disease type Ia.
  • BACKGROUND/AIMS: Because dietary modifications have prolonged the life expectancy of patients with glycogen storage disease type Ia (GSD Ia), the incidence of hepatocellular adenoma (HCA) to carcinoma (HCC) transformation is increasing.
  • The objective of this retrospective study is to assess the safety and effectiveness of HCA resection in GSD Ia patients.
  • METHODS: Clinicopathologic, peri-operative, and long-term data were reviewed from patients who underwent HCA resection.
  • Comparisons were made with Fisher's exact, Mann-Whitney U, and log-rank tests; survival was estimated with Kaplan-Meier analysis.
  • RESULTS: From 1998 to 2006, 38 patients underwent HCA resection.
  • GSD Ia patients had greater morbidity (86% vs. 20%) and shorter time to adenoma progression (median 23 months vs. not yet reached) after partial hepatectomy compared to the general population (p<0.05).
  • Three GSD Ia patients underwent liver transplantation 77, 32, and 23 months after adenoma resection.
  • CONCLUSIONS: Despite substantial morbidity, partial hepatectomy is feasible in GSD Ia patients and is an effective intermediate step in the prevention of HCC until definitive treatment with liver transplantation.
  • [MeSH-major] Adenoma, Liver Cell / surgery. Biliary Tract Surgical Procedures / statistics & numerical data. Glycogen Storage Disease Type I / complications. Liver / surgery. Liver Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Comorbidity. Disease Progression. Female. Humans. Liver Transplantation / statistics & numerical data. Male. Middle Aged. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17637480.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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91. Kakarla UK, Beres EJ, Ponce FA, Chang SW, Deshmukh VR, Bambakidis NC, Zabramski JM, Spetzler RF: Microsurgical treatment of pediatric intracranial aneurysms: long-term angiographic and clinical outcomes. Neurosurgery; 2010 Aug;67(2):237-49; discussion 250
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  • Rates of aneurysm recurrence and de novo formation were calculated.
  • Hypothermic circulatory arrest was used to treat 10 aneurysms (14%), all involving the basilar artery.
  • At angiographic follow-up (mean, 53 months; median, 32 months), the annual recurrence rate was 2.6%, and the annual rate of de novo formation or growth was 7.8%.
  • They leave higher rates of recurrence and de novo formation or growth than their adult counterparts, which mandates lifelong follow-up.

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  • (PMID = 20539250.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Della Porta MG, Malcovati L, Boveri E, Travaglino E, Pietra D, Pascutto C, Passamonti F, Invernizzi R, Castello A, Magrini U, Lazzarino M, Cazzola M: Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes. J Clin Oncol; 2009 Feb 10;27(5):754-62
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  • [Title] Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes.
  • CD34+ cell clusters were found in 23% of patients and were associated with WHO categories with excess of blasts (P < .001) and poor-risk cytogenetics (P = .001).
  • In multivariable analysis, BM fibrosis and presence of CD34+ cell clusters had independent negative impact on overall survival (P < .001 and P = .019, respectively) and leukemia-free survival (P < .001 and P = .004, respectively).
  • A hierarchical clustering analysis identified three subsets of patients with distinct clinical features.
  • Furthermore, the presence of CD34+ cell clusters is an independent risk factor for progression to acute leukemia.
  • [MeSH-major] Antigens, CD34 / analysis. Bone Marrow / pathology. Myelodysplastic Syndromes / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fibrosis. Humans. Leukemia, Myelomonocytic, Acute / pathology. Male. Middle Aged. Prognosis. Retrospective Studies


93. Stav D, Bar I, Sandbank J: Gene expression subtraction of non-cancerous lung from smokers and non-smokers with adenocarcinoma, as a predictor for smokers developing lung cancer. J Exp Clin Cancer Res; 2008;27:45
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  • Hierarchical clustering analysis on genes obtained from smokers and non-smokers, after subtracting were exported to the Ingenuity Pathway Analysis software for further analysis.
  • The gene functional analysis disclosed 20 genes, which are involved in cancer process (P = 7.05E-5 to 2.92E-2).

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  • [Cites] BMJ. 2000 Aug 5;321(7257):323-9 [10926586.001]
  • [Cites] Lung Cancer. 2007 Sep;57(3):253-60 [17451842.001]
  • [Cites] Cancer Res. 2002 Apr 15;62(8):2370-7 [11956099.001]
  • [Cites] Chest. 2003 Jan;123(1 Suppl):21S-49S [12527563.001]
  • [Cites] J Clin Oncol. 2003 Mar 1;21(5):921-6 [12610194.001]
  • [Cites] J Mol Diagn. 2003 May;5(2):103-12 [12707375.001]
  • [Cites] Am J Respir Cell Mol Biol. 2003 Aug;29(2):157-62 [12600827.001]
  • [Cites] Am Rev Respir Dis. 1991 Aug;144(2):307-11 [1859052.001]
  • [Cites] Environ Health Perspect. 1995 Nov;103 Suppl 8:131-42 [8741773.001]
  • [Cites] Clin Cancer Res. 1999 Aug;5(8):2025-34 [10473082.001]
  • [Cites] Cancer. 1953 Sep;6(5):963-8 [13094644.001]
  • [Cites] Methods Mol Biol. 2006;338:191-208 [16888360.001]
  • [Cites] Thorax. 2007 Jan;62(1):51-6 [16928722.001]
  • [Cites] Clin Cancer Res. 2007 Jan 1;13(1):52-8 [17200338.001]
  • [Cites] Nucleic Acids Res. 2007 Jan;35(Database issue):D747-50 [17132828.001]
  • [Cites] Oncol Rep. 2001 Jan-Feb;8(1):63-5 [11115570.001]
  • (PMID = 18811983.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2570656
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94. Minami K, Maniratanachote R, Katoh M, Nakajima M, Yokoi T: Simultaneous measurement of gene expression for hepatotoxicity in thioacetamide-administered rats by DNA microarrays. Mutat Res; 2006 Jan 31;603(1):64-73
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  • TA was intraperitoneally administered at high (400 mg/kg), medium (150 mg/kg) or low (50 mg/kg) dose (four rats per group) and then the serum and liver were collected at the indicated time (6, 12, 24, 36 and 48 h).
  • Serum biochemical markers were measured and hepatic mRNA expression profiles were analyzed by a DNA microarray.
  • Hierarchical clustering analysis of all dosage groups revealed in 2 major clusters, distinguished by an early (6 and 12h) and a late (24, 36 and 48 h) phase.
  • The major gene expression profile obtained by quality-threshold (QT) clustering analysis showed the same maximal toxic time as that estimated by the serum biochemical markers.
  • This study suggested that the major gene expression profile estimated by QT clustering would be a sensitive marker of hepatotoxicity.
  • [MeSH-minor] Alanine Transaminase / biosynthesis. Alanine Transaminase / blood. Animals. Aspartate Aminotransferases / biosynthesis. Aspartate Aminotransferases / blood. Biomarkers / analysis. Dose-Response Relationship, Drug. Male. Oligonucleotide Array Sequence Analysis. Quality Control. RNA, Messenger / biosynthesis. Rats. Rats, Sprague-Dawley. Sensitivity and Specificity

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  • (PMID = 16337175.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / RNA, Messenger; 075T165X8M / Thioacetamide; EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
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95. Riesenman PJ, Tamaddon HS, Farber MA: Surgical bypass procedures to facilitate endovascular repair of aortic arch pathology. J Cardiovasc Surg (Torino); 2008 Aug;49(4):461-9
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  • Thoracic aortic lesions involving the aortic arch require more complex surgical interventions necessitating cardiopulmonary bypass, and hypothermic circulatory arrest.
  • The application of a thoracic endoprosthesis may be limited by the extent of involvement of the proximal thoracic aorta as coverage of arch vessel ostia may be necessary to obtain adequate proximal endograft fixation and aneurysm exclusion.
  • In an effort to overcome proximal landing zone limitations imposed by arch vessel involvement, hybrid surgical-endovascular reconstructive and debranching bypass procedures have been performed to create a proximal landing zone of adequate length.
  • Although these adjunctive techniques incorporate invasive surgical procedures, it is believed that minimizing the procedural invasiveness, by avoiding aortic cross-clamping and/or hypothermic circulatory arrest, morbidity and mortality outcomes can be improved especially in high-risk patients.
  • Several surgical approaches and techniques have been described for various levels of aortic arch involvement with encouraging early and mid-term results, although the long-term durability of these hybrid surgical-endovascular procedures remains to be defined.

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  • (PMID = 18665108.001).
  • [ISSN] 0021-9509
  • [Journal-full-title] The Journal of cardiovascular surgery
  • [ISO-abbreviation] J Cardiovasc Surg (Torino)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 50
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96. Redline RW, Minich N, Taylor HG, Hack M: Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (&lt;1 kg). Pediatr Dev Pathol; 2007 Jul-Aug;10(4):282-92
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  • We conducted a secondary analysis of placental pathology in a cohort study of inborn singleton ELBW infants born between 1992 and 1995 and evaluated for cerebral palsy (CP) and abnormal neurocognitive testing at 8 years of age (N = 129).
  • Histologic chorioamnionitis (HCA) was not predictive of outcome in the population as a whole, but a severe fetal vascular response was associated with a lower NEPSY score in the subpopulation with HCA (N = 69).
  • Placentas with increased syncytial knots, villous edema, and those with neither finding constituted nonoverlapping subgroups with distinct pathologic and perinatal characteristics.
  • Among infants with villous edema (N = 25), those with neurologic impairment had lower gestational ages and more severe degrees of HCA.
  • However, by logistic regression these other factors were not independent risk factors for abnormal neurocognitive testing, and only HCA with a severe fetal vascular response decreased the association of villous edema with low test scores for NEPSY, but not K-ABC.

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  • [CommentIn] Pediatr Dev Pathol. 2008 Mar-Apr;11(2):164 [18422400.001]
  • (PMID = 17638433.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Joshi AD, Corral R, Siegmund KD, Haile RW, Le Marchand L, Martínez ME, Ahnen DJ, Sandler RS, Lance P, Stern MC: Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis; 2009 Mar;30(3):472-9
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  • Diets high in red meat have been consistently associated with colorectal cancer (CRC) risk and may result in exposure to carcinogens that cause DNA damage [i.e polycyclic aromatic hydrocarbons, heterocyclic amines (HCAs) and N-nitroso compounds].
  • We tested for gene-environment interactions using case-only analyses (n = 577) and compared the results using case-unaffected sibling comparisons (n = 307 sibships).
  • Case-unaffected sibling analyses were generally supportive of the case-only results.

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  • [Cites] Drug Metab Rev. 2001 Feb;33(1):1-35 [11270659.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2331-43 [17982118.001]
  • [Cites] Hum Mol Genet. 2001 Sep 1;10(18):1889-900 [11555625.001]
  • [Cites] Mutat Res. 2001 Nov 1;483(1-2):95-104 [11600138.001]
  • [Cites] Cancer Res. 2001 Oct 15;61(20):7430-4 [11606376.001]
  • [Cites] Environ Mol Mutagen. 2001;38(4):323-8 [11774364.001]
  • [Cites] Nucleic Acids Res. 2002 Aug 15;30(16):3624-31 [12177305.001]
  • [Cites] Drug Metab Rev. 2002 Aug;34(3):625-50 [12214671.001]
  • [Cites] Mutat Res. 2002 Sep 30;506-507:175-85 [12351157.001]
  • [Cites] Mutat Res. 2002 Sep 30;506-507:205-14 [12351160.001]
  • [Cites] J Nutr. 2002 Nov;132(11 Suppl):3522S-3525S [12421881.001]
  • [Cites] Am J Epidemiol. 2003 Mar 1;157(5):434-45 [12615608.001]
  • [Cites] J Nutr. 2004 Apr;134(4):776-84 [15051825.001]
  • [Cites] Cancer Causes Control. 2004 Apr;15(3):225-36 [15090717.001]
  • [Cites] Nutrition. 2004 Oct;20(10):873-7 [15474875.001]
  • [Cites] Int J Toxicol. 2004;23(5):301-33 [15513831.001]
  • [Cites] IARC Sci Publ. 1976;(14):333-42 [1033916.001]
  • [Cites] Cancer Surv. 1987;6(4):719-38 [3330686.001]
  • [Cites] Am J Epidemiol. 1989 Jan;129(1):125-37 [2910056.001]
  • [Cites] Cancer Res. 1992 Apr 1;52(7 Suppl):2092s-2098s [1544146.001]
  • [Cites] Nat Genet. 1995 Jun;10(2):188-95 [7663514.001]
  • [Cites] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138.001]
  • [Cites] Carcinogenesis. 1996 Mar;17(3):515-23 [8631138.001]
  • [Cites] Am J Epidemiol. 1996 Aug 1;144(3):207-13 [8686689.001]
  • [Cites] Carcinogenesis. 1996 Sep;17(9):2081-3 [8824539.001]
  • [Cites] Mutat Res. 1997 May 12;376(1-2):107-14 [9202745.001]
  • [Cites] Mutat Res. 1998 Sep 20;405(2):135-43 [9748543.001]
  • [Cites] Carcinogenesis. 1999 Apr;20(4):545-51 [10223180.001]
  • [Cites] Adv Exp Med Biol. 1999;459:179-93 [10335376.001]
  • [Cites] Am J Epidemiol. 2005 Jan 1;161(1):1-14 [15615908.001]
  • [Cites] JAMA. 2005 Jan 12;293(2):172-82 [15644544.001]
  • [Cites] Carcinogenesis. 2005 Mar;26(3):637-42 [15579480.001]
  • [Cites] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978.001]
  • [Cites] Cancer Res. 2006 Feb 1;66(3):1859-65 [16452248.001]
  • [Cites] Toxicol Appl Pharmacol. 2006 Apr 15;212(2):136-45 [16137733.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2263-9 [17119055.001]
  • [Cites] Mutat Res. 2007 Jun 1;619(1-2):68-80 [17363013.001]
  • [Cites] Mutat Res. 2007 May-Jun;635(2-3):118-45 [17419091.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2000 Aug;9(8):843-7 [10952103.001]
  • [Cites] J Natl Cancer Inst Monogr. 1999;(26):89-93 [10854491.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):439-46 [11352852.001]
  • (PMID = 19029193.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA074799; United States / NIEHS NIH HHS / ES / 5P30 ES07048; United States / PHS HHS / / 5UO1074799
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens
  • [Other-IDs] NLM/ PMC2722151
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98. Weigelt B, Horlings HM, Kreike B, Hayes MM, Hauptmann M, Wessels LF, de Jong D, Van de Vijver MJ, Van't Veer LJ, Peterse JL: Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol; 2008 Oct;216(2):141-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We aimed to refine the breast cancer classification systems by analysing a series of 11 histological special types [invasive lobular carcinoma (ILC), tubular, mucinous A, mucinous B, neuroendocrine, apocrine, IDC with osteoclastic giant cells, micropapillary, adenoid cystic, metaplastic, and medullary carcinoma] using immunohistochemistry and genome-wide gene expression profiling.
  • Hierarchical clustering analysis confirmed that some histological special types constitute discrete entities, such as micropapillary carcinoma, but also revealed that others, including tubular and lobular carcinoma, are very similar at the transcriptome level.
  • Our analysis also revealed that some special types associated with a good prognosis, such as medullary and adenoid cystic carcinomas, display a poor prognosis basal-like transcriptome, providing strong circumstantial evidence that basal-like cancers constitute a heterogeneous group.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cluster Analysis. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Signal Transduction / genetics. Statistics, Nonparametric


99. Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J: Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth. Mol Biol Cell; 2010 Aug 1;21(15):2797-807
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  • Naturally ligand independent constitutively active gp130 variants were described to be responsible for inflammatory hepatocellular adenomas.
  • Moreover, these receptor combinations induced transcription of the STAT3 target genes c-myc and Pim-1 and factor-independent growth of stably transduced Ba/F3-gp130 cells.
  • [MeSH-minor] Animals. Cattle. Cell Line. Cell Proliferation. Cytokines / metabolism. Extracellular Signal-Regulated MAP Kinases / metabolism. Humans. Interleukin-15 / metabolism. Interleukin-15 Receptor alpha Subunit / metabolism. Ligands. Mice. STAT Transcription Factors / metabolism. Transcription, Genetic


100. Li T, Qin LX, Ji Y, Sun HC, Ye QH, Wang L, Pan Q, Fan J, Tang ZY: Atypical hepatic focal nodular hyperplasia presenting as acute abdomen and misdiagnosed as hepatocellular carcinoma. Hepatol Res; 2007 Dec;37(12):1100-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical hepatic focal nodular hyperplasia presenting as acute abdomen and misdiagnosed as hepatocellular carcinoma.
  • Focal nodular hyperplasia (FNH) is a rare benign hepatic lesion, which is usually asymptomatic and solitary.
  • We report a case of a 26-year-old woman with spontaneous rupture and hemorrhage of huge FNH presenting as acute abdomen.
  • Different to previously recorded cases, this case was concomitant with multiple hepatic adenomas, which was misdiagnosed as rupture of hepatocellular carcinoma (HCC) with multiple intrahepatic spreading in another hospital.

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  • (PMID = 17608671.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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