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25. Chen ZM, Scudiere JR, Abraham SC, Montgomery E: Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. Am J Surg Pathol; 2009 Feb;33(2):186-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.
  • Pyloric gland adenoma (PGA) is a rare neoplasm demonstrating gastric epithelial differentiation.
  • We compared them to 28 gastric foveolar type gastric adenomas (GTAs) from 25 patients.
  • Morphologically, PGAs were characterized by closely packed pyloric gland-type tubules with a monolayer of cuboidal to low columnar epithelial cells containing round nuclei and pale to eosinophilic cytoplasm with a ground glass appearance.
  • Despite its bland histologic appearance, it is much more likely to be accompanied by background IM and autoimmune gastritis and can evolve into invasive adenocarcinoma displaying pyloric gland differentiation.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Stomach Neoplasms / pathology

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  • (PMID = 18830123.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucin-6
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26. Hes O, Síma R, Nemcová J, Hora M, Bulimbasic S, Kazakov DV, Urge T, Reischig T, Dvorák M, Michal M: End-stage kidney disease: gains of chromosomes 7 and 17 and loss of Y chromosome in non-neoplastic tissue. Virchows Arch; 2008 Oct;453(4):313-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] End-stage kidney disease: gains of chromosomes 7 and 17 and loss of Y chromosome in non-neoplastic tissue.
  • The aim of this study was to determine the copy number changes of chromosomes 7, 17, 3p, and Y in a non-neoplastic tubular epithelium in end-stage kidney disease (ESKD).
  • Tissues containing papillary adenomas (PA), clear (CRCC) and papillary renal cell carcinomas (PRCC), and myxoid liposarcoma (LPS) were examined using the same probes and compared with non-neoplastic tissue.
  • The basal membranes were lined by large eosinophilic epithelial cells with polymorphic nuclei and pseudostratification.
  • Fluorescence in situ hybridization on tissues containing papillary adenomas, renal cell carcinomas, and liposarcoma revealed expected results, i.e., trisomy of chromosomes 7 and 17 in all PAs and PRCC.
  • [MeSH-minor] Adenoma / genetics. Adult. Aged. Carcinoma, Renal Cell / genetics. Female. Humans. In Situ Hybridization, Fluorescence. Kidney Tubules / pathology. Liposarcoma, Myxoid / genetics. Male. Middle Aged. Trisomy / genetics. Trisomy / pathology

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  • (PMID = 18795325.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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27. Kiziltaş S, Sezgin Ramadan S, Topuzoğlu A, Küllü S: Does the severity of tissue eosinophilia of colonic neoplasms reflect their malignancy potential? Turk J Gastroenterol; 2008 Dec;19(4):239-44
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  • BACKGROUND/AIMS: It was speculated that there was a relationship between the intensity of tissue eosinophilic infiltration in colonic malignancies and their prognosis.
  • This retrospective study aimed to investigate the frequency and intensity of tissue eosinophilia in various colonic neoplasms, including serrated adenomas.
  • METHODS: We evaluated 448 colonic neoplasms to determine eosinophilic infiltration: 96 hyperplastic polyps, 50 serrated adenomas, 19 flat adenomas, 154 tubular adenomas, 71 tubulovillous adenomas, 13 villous adenomas and 45 adenocarcinomas.
  • The eosinophilic infiltration was categorized into three groups by evaluating the percentage of eosinophils relative to total stromal inflammatory cells: mild (0-5%), moderate (5-40%), and marked (>;40%).
  • RESULTS: Moderate (46.7%) and marked (52.9%) intensity were noted in all colonic adenomas.
  • Mostly moderate eosinophilic infiltration was observed in serrated adenomas.
  • CONCLUSIONS: Our findings suggest that the intensity of tissue eosinophilia is most prominent in adenomas including serrated adenomas and is diminished from adenoma to carcinoma.
  • This finding may be used as a diagnostic indicator.

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  • (PMID = 19119482.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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