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1. Katsinelos P, Basdanis G, Chatzimavroudis G, Karagiannoulou G, Katsinelos T, Paroutoglou G, Papaziogas B, Paraskevas G: Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. World J Gastroenterol; 2006 Aug 14;12(30):4927-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreatitis complicating mucin-hypersecreting common bile duct adenoma.
  • Villous adenomas of the bile ducts are extremely uncommon.
  • Preoperative investigation demonstrated a dilated papillary orifice with mucus exiting (fish-mouth sign) and a filling defect in the distal common bile duct.
  • He underwent a modified Whipple operation and histological examination of the surgical specimen showed villous adenoma with rich secretion of mucus.
  • [MeSH-major] Adenoma, Bile Duct / complications. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Mucins / secretion. Pancreatitis / etiology

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  • (PMID = 16937485.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucins
  • [Other-IDs] NLM/ PMC4087637
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2. Aparajita R, Gomez D, Verbeke CS, Menon KV: Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum. JOP; 2008;9(2):212-5
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  • [Title] Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum.
  • CONTEXT: Benign tumours of the biliary tract are an extremely rare group of neoplasms.
  • Coincidence of a biliary adenoma of the distal common bile duct and a synchronous adenocarcinoma of the peri-ampullary duodenum has never been reported in the literature.
  • CASE REPORT: We report a case of a papillary adenoma in the common bile duct in a 75-year-old female, who had synchronous invasive adenocarcinoma of the peri-ampullary duodenum.
  • CONCLUSION: Isolated papillary adenoma of the bile duct is extremely rare, and in this unusual case it coincided with a peri-ampullary duodenal adenocarcinoma.
  • However, this is a rare instance of an incidental finding within the distal bile duct following pancreaticoduodenectomy for curative treatment of a peri-ampullary adenocarcinoma.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Common Bile Duct / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18326932.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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3. Lee TS, Kim HK, Ahn HM, Lee UJ, Choi YC, John BM, Park TI, Koo JH: [A case of early bile duct cancer arising from villous adenoma in choledochal cyst]. Korean J Gastroenterol; 2009 Jul;54(1):55-9
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  • [Title] [A case of early bile duct cancer arising from villous adenoma in choledochal cyst].
  • Herein, we report a rare case of bile duct adenoma arising from choledochal cyst with anomalous union of pancreaticobiliary duct (AUPBD).
  • She had received common bile duct (CBD) exploration and choledocholithotomy and cholecystectomy 3 months earlier under the diagnosis of multiple CBD stones.
  • On magnetic resonance cholangiopancreatography, the filling defect was confirmed as 2 cm polypoid mass attached to the distal bile duct wall.
  • On histological examination, adenoma with focal carcinoma change arising from choledochal cyst was diagnosed.
  • [MeSH-major] Adenoma, Villous / diagnosis. Bile Duct Neoplasms / diagnosis. Choledochal Cyst / diagnostic imaging

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  • (PMID = 19696552.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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4. Schönleben F, Qiu W, Allendorf JD, Chabot JA, Remotti HE, Su GH: Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. J Gastrointest Surg; 2009 Aug;13(8):1510-6
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  • [Title] Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.
  • BACKGROUND: Mutations of KRAS are known to occur in periampullary and ampullary adenomas and carcinomas.
  • This study aimed to elucidate possible roles of BRAF and PIK3CA in the development of ampullary and periampullary adenomas and carcinomas.
  • METHODS: Mutations of BRAF, NRAS, HRAS, KRAS, and PIK3CA were evaluated in seven adenomas, seven adenomas with carcinoma in situ, and 21 adenocarcinomas of the periampullary duodenal region and the ampulla of Vater.

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  • (PMID = 19440799.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701; United States / NCI NIH HHS / CA / CA127701-01A2; United States / NCI NIH HHS / CA / R01CA109525; United States / NCI NIH HHS / CA / R01 CA109525; United States / NCI NIH HHS / CA / CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701-01A2; United States / NCI NIH HHS / CA / R21CA127701
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS164917; NLM/ PMC3915027
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5. Kim BS, Joo SH, Joo KR: Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report. World J Gastroenterol; 2008 Aug 7;14(29):4705-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report.
  • Tubulovillous adenomas are common in the colon and rectum, but are rare in the common bile duct.
  • Biliary adenomas may produce obstructive jaundice, which can be easily confused with a malignant neoplasm or stone.
  • We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice.
  • Abdominal sonography and computed tomography showed a mass in the distal common bile duct.
  • Endoscopic retrograde cholangiopancreatography showed luminal narrowing of the bile duct due to a polypoid mass.
  • The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct.
  • The polyps were removed by endoscopic mucosal resection and shown to be tubular adenomas with high grade dysplasia.
  • Biliary adenomas require careful follow-up for early detection of recurrence and malignant transformation.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 18698689.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738799
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6. Mosnier JF, Kandel C, Cazals-Hatem D, Bou-Hanna C, Gournay J, Jarry A, Laboisse CL: N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. Mod Pathol; 2009 Feb;22(2):182-90
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  • As a definite immunoprofile of this tumor is missing, the histopathologic diagnosis of intrahepatic cholangiocarcinoma is difficult.
  • The aim of this study was to explore E- and N-cadherin expressions in intrahepatic bile duct tumors, and to determine their potential interest in differential diagnosis.
  • Normal liver tissue, 5 cirrhosis with ductular reaction, 5 focal nodular hyperplasia, 5 bile duct hamartomas, 5 bile duct adenomas, and 45 intrahepatic cholangiocarcinomas from Caucasian patients were studied.
  • In normal liver, epithelial cells of intrahepatic bile ducts, whatever their caliber, as well as hepatocytes, coexpressed E- and N-cadherins at their plasma membranes.
  • All the benign lesions and 30 of the 45 intrahepatic cholangiocarcinomas (23/29 peripheral and 7/16 hilar) also expressed N-cadherin.
  • [MeSH-major] Antigens, CD / analysis. Bile Duct Neoplasms / immunology. Bile Ducts, Intrahepatic / immunology. Biomarkers, Tumor / analysis. Cadherins / analysis. Cholangiocarcinoma / immunology

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  • (PMID = 18622386.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CDH1 protein, human; 0 / CDH2 protein, human; 0 / Cadherins; 0 / KRT7 protein, human; 0 / Keratin-7
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7. Kim YS, Rha SE, Oh SN, Jung SE, Shin YR, Choi BG, Byun JY, Jung ES, Kim DG: Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review. Korean J Radiol; 2010 Sep-Oct;11(5):560-5
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  • [Title] Imaging findings of intrahepatic bile duct adenoma (peribiliary gland hamartoma): a case report and literature review.
  • Intrahepatic bile duct adenoma is a rare benign epithelial hepatic tumor derived from bile duct cells.
  • We report the imaging findings of a patient with bile duct adenoma, which appeared as a small heterogeneously enhancing mass with focal small cystic change on CT and MRI.
  • Although rare, bile duct adenoma should be considered as a differential diagnosis of a small hypervascular tumor located in the periphery of liver.
  • [MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Hamartoma / diagnosis

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  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for bile duct adenoma .
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  • (PMID = 20808701.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ PMC2930166
  • [Keywords] NOTNLM ; Adenoma / Bile duct / Computed tomography (CT) / Liver / Magnetic resonance (MR)
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8. Maeda E, Uozumi K, Kato N, Akahane M, Inoh S, Inoue Y, Beck Y, Goto A, Makuuchi M, Ohtomo K: Magnetic resonance findings of bile duct adenoma with calcification. Radiat Med; 2006 Jul;24(6):459-62
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  • [Title] Magnetic resonance findings of bile duct adenoma with calcification.
  • Computed tomographic (CT) and magnetic resonance (MR) appearances of bile duct adenoma (BDA in a patient who underwent partial hepatectomy of segment 8 are presented.
  • [MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Calcinosis / diagnosis. Magnetic Resonance Imaging

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  • (PMID = 16958429.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Hughes NR, Goodman ZD, Bhathal PS: An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. Am J Surg Pathol; 2010 Sep;34(9):1312-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis.
  • The so-called bile duct adenoma and peribiliary glands are characterized by the expression of two foregut antigens (designated D10 and 1F6) and secretion of acid mucin.
  • On account of this similarity in phenotype and their frequent close association with a large caliber bile duct, it was earlier suggested that bile duct adenoma represent a peribiliary gland hamartoma.
  • Here, we compare the expression of 13 tissue antigens in bile duct adenomas, other benign bile duct lesions, and various foregut-derived tissues, to further investigate the bile duct adenoma phenotype and pathogenesis.
  • Five foregut antigens (D10, 1F6, MUC6, MUC5AC, and TFF2) and secretion of acid mucin were of use in distinguishing bile duct adenoma from other hepatic lesions.
  • 1F6 and MUC6 were normally present in bile ductules and canals of Hering, whereas the epithelium lining the larger bile ducts stained focally for D10, MUC5AC, MUC6, or TFF2 in, respectively, 21%, 36%, 43%, and 100% of the livers examined.
  • Thirty-six bile duct adenomas examined were distinguished by expression of MUC6 (94% of bile duct adenoma), MUC5AC (90%), TFF2 (80%), D10 (67%), and 1F6 (61%), and varying degrees of acid mucin secretion (100%).
  • Of 30 bile duct adenoma tested for all 5 antigens, 40% expressed all 5, 27% expressed 4, 17% expressed 3, 13% expressed 2, and 1 expressed only MUC6.
  • The distinguishing feature of so-called bile duct adenoma is their display of the same phenotype as pyloric gland metaplasia.
  • It is concluded that they develop as a localized biliary healing response equivalent to the function of a peribiliary gland or pyloric gland metaplasia in the foregut.
  • [MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology

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  • (PMID = 20679879.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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10. Hornick JL, Lauwers GY, Odze RD: Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Am J Surg Pathol; 2005 Mar;29(3):381-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver.
  • Not uncommonly, bile duct adenomas (BDAs) and hamartomas (BDHs) of the liver may be difficult to distinguish from metastatic well-differentiated ductal adenocarcinoma of the pancreas.
  • The slides were evaluated in a blinded fashion, and the results were compared between the benign and malignant lesions.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma / pathology. Bile Duct Neoplasms / pathology. Hamartoma / pathology. Liver Diseases / pathology. Pancreatic Neoplasms / pathology


11. Kunisaki SM, Hertl M, Bodner BE, Cosimi AB: Mirizzi syndrome secondary to an adenoma of the cystic duct. J Hepatobiliary Pancreat Surg; 2005;12(2):159-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mirizzi syndrome secondary to an adenoma of the cystic duct.
  • Bile duct adenomas are uncommon lesions that can cause obstructive jaundice.
  • We report the unusual case of a 54-year-old man who developed Mirizzi syndrome secondary to a bile duct papillary adenoma located in the cystic duct remnant.
  • A case report is presented, together with a review of extrahepatic bile duct adenomas published in the English-language literature, with special attention directed toward the clinical manifestations, locations, and prognosis of these tumors.
  • Bile duct adenomas are very rare tumors.
  • Most lesions were located in the distal common bile duct or at the ampulla of Vater.
  • There were no previous case reports of extrinsic common bile duct obstruction caused by tumors within the cystic duct.
  • We describe here a very rare, acalculous variant of Mirizzi syndrome secondary to a solitary papillary adenoma of the cystic duct.
  • In general, bile duct adenomas are uncommon lesions that are difficult to diagnoses preoperatively.
  • [MeSH-major] Adenoma / complications. Bile Duct Neoplasms / complications. Cholestasis / etiology. Cystic Duct

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  • (PMID = 15868083.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 28
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12. Takahashi S, Takada K, Kawano Y, Miyanishi K, Ishiwatari H, Hayashi T, Sagawa T, Sato T, Sato Y, Takimoto R, Kobune M, Kuroiwa G, Hirayama M, Tobioka H, Hirata K, Omatsu M, Hasegawa T, Kato J: [Cholangiocarcinoma with bile duct adenoma and hamartoma-like lesion in the bile duct]. Nihon Shokakibyo Gakkai Zasshi; 2010 Mar;107(3):461-9
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  • [Title] [Cholangiocarcinoma with bile duct adenoma and hamartoma-like lesion in the bile duct].
  • This showed a number of bile ductules with variable amounts of stroma, well circumscribed but not encapsulated, so the lesion was diagnosed as a cholangiocarcinoma.
  • In addition, cystically dilated ductules resembling bile duct hamartoma and bile duct adenoma adjacent to the tumor were found, but with no area of transition among them.
  • In the Glisson's capsule around the tumor, there was also a bile duct hamartoma.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology. Hamartoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20203450.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Ignee A, Piscaglia F, Ott M, Salvatore V, Dietrich CF: A benign tumour of the liver mimicking malignant liver disease--cholangiocellular adenoma. Scand J Gastroenterol; 2009;44(5):633-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A benign tumour of the liver mimicking malignant liver disease--cholangiocellular adenoma.
  • OBJECTIVE: To describe three patients with liver lesions mimicking malignant tumours diagnosed finally, using contrast-enhanced ultrasound, as cholangiocellular adenoma (bile duct adenoma).
  • Pathological analysis (including the reference pathology) revealed cholangiocellular adenoma in all of them.
  • CONCLUSION: Cholangiocellular adenoma is a rare entity and can be a reason for possible false malignant diagnosis using contrast-enhanced ultrasound.
  • [MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Liver Neoplasms / pathology

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  • (PMID = 19396663.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Phospholipids; 0 / contrast agent BR1; WS7LR3I1D6 / Sulfur Hexafluoride
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14. Morris-Stiff GJ, Senda Y, Verbeke CS, Lodge PA: Papillary adenoma arising in the left hepatic duct: an unusual tumour in an uncommon location. Eur J Gastroenterol Hepatol; 2010 Jul;22(7):886-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary adenoma arising in the left hepatic duct: an unusual tumour in an uncommon location.
  • Bile duct adenomas are rare tumours that arise more frequently in the distal extrahepatic biliary tree.
  • We report the case of a papillary adenoma arising at the junction of the common and left hepatic ducts and review the available literature on this rare entity.
  • Histological evaluation of the resected specimen confirmed a papillary adenoma with mild dysplasia.
  • [MeSH-major] Adenoma / diagnosis. Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic

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  • (PMID = 20545030.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.3.2.2 / gamma-Glutamyltransferase
  • [Number-of-references] 10
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15. Munshi AG, Hassan MA: Common bile duct adenoma: case report and brief review of literature. Surg Laparosc Endosc Percutan Tech; 2010 Dec;20(6):e193-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Common bile duct adenoma: case report and brief review of literature.
  • Papillary adenomas of the common bile duct are a rare entity with few published case reports and limited knowledge on its natural progression.
  • We report here a case of common bile duct papillary adenoma in a 69-year-old female who presented with symptoms of common bile duct obstruction.
  • She was treated with local endoscopic excision of the mass that has benign features.
  • A brief review of literature is discussed with a proposed treatment plan for follow-up with surveillance endoscopy and ultrasonography as opposed to the radical resection for benign findings on pathology.
  • [MeSH-major] Adenoma / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct / pathology. Common Bile Duct Diseases / diagnosis. Dilatation, Pathologic. Female. Humans. Sphincterotomy, Endoscopic

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  • (PMID = 21150400.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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16. Sotona O, Cecka F, Neoral C, Ferko A, Rejchrt S, Podhola M, Subrt Z, Jon B: Papillary adenoma of the extrahepatic biliary tract--a rare cause of obstructive jaundice. Acta Gastroenterol Belg; 2010 Apr-Jun;73(2):270-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary adenoma of the extrahepatic biliary tract--a rare cause of obstructive jaundice.
  • The authors present a case of papillary adenoma of the extrahepatic biliary tract presenting as obstructive jaundice.
  • The patient was treated by bile duct resection with Roux-en-Y hepaticojejunostomy.
  • Adenoma of the bile duct is a rare entity.
  • [MeSH-major] Adenoma / complications. Bile Duct Neoplasms / complications. Bile Ducts, Extrahepatic. Jaundice, Obstructive / etiology

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  • (PMID = 20690568.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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17. Evert M, Schildhaus HU, Schneider-Stock R, Dombrowski F: Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats. Virchows Arch; 2006 Jun;448(6):776-87
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  • [Title] Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats.
  • Islet transplantation is increasingly used as a therapy for human type 1 diabetes mellitus.
  • In our study, we investigated the effect of the transplantation of a low number (n = 350) of pancreatic islets into the right liver part on the neighboring portal bile ducts.
  • During the next 12-24 months, many peri-insular ductules progressed via tumor-like cystic lesions to large cystic cholangiomas, accompanied by a translocation of the insulin receptor into the cytoplasm and an increase in expression of insulin-related signaling proteins (Insulin-receptor-substrate-1, Raf-1, Mek-1).
  • After 24 months, 53% of rats with low-number transplantation exhibited at least one cholangioma >10 mm, significantly outnumbering tumor development in the transplant-free left liver part and in any control group.
  • Conclusively, low-number intrahepatic islet transplantation, most likely acting by permanent local hyperinsulinism, leads to prolonged cholangiocellular proliferation in streptozotocin- and in autoimmune-diabetic rats, resulting in the development of benign cystic cholangiomas.
  • [MeSH-major] Adenoma, Bile Duct / etiology. Bile Duct Neoplasms / etiology. Bile Ducts, Intrahepatic / pathology. Diabetes Mellitus, Experimental / complications. Diabetes Mellitus, Type 1 / complications. Islets of Langerhans Transplantation / adverse effects


18. Akaydin M, Ersoy YE, Erozgen F, Ferlengez E, Kaplan R, Celik A, Memmi N: Tubulovillous adenoma in the common bile duct causing obstructive jaundice. Acta Gastroenterol Belg; 2009 Oct-Dec;72(4):450-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubulovillous adenoma in the common bile duct causing obstructive jaundice.
  • Villous adenomas are benign epithelial lesions with a malignant potential which can occur at any site in the gastrointestinal tract, usually in the rectum and colon, less frequently in the small bowel and very rarely in the biliary tract.
  • Villous adenomas of the extrahepatic bile ducts are exceptional and only a few cases have been reported.
  • Common bile duct (CBD) adenomas often present in a fashion similar to their malignant counterparts, and adenocarcinoma arising from a villous adenoma of the ampullary biliary epithelium is also extremely rare.
  • We present here a tubulovillous adenoma, arising in the common bile duct, as a cause of obstructive jaundice, and discuss the characteristics of these lesions.
  • [MeSH-major] Adenoma, Villous / complications. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology

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  • (PMID = 20163042.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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19. Jakab C, Kiss A, Schaff Z, Szabó Z, Rusvai M, Gálfi P, Szabára A, Sterczer A, Kulka J: Claudin-7 protein differentiates canine cholangiocarcinoma from hepatocellular carcinoma. Histol Histopathol; 2010 07;25(7):857-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS AND RESULTS: Necropsy samples included 15 canine normal liver tissue samples, 10 hepatocellular nodular hyperplasias, 6 hepatocellular adenomas, 15 well-differentiated and 6 poorly differentiated hepatocellular carcinomas, 6 cholangiocellular hyperplasias, 10 cholangiocellular adenomas, 15 well-differentiated and 6 poorly differentiated cholangiocarcinomas, 6 normal extrahepatic bile ducts, 8 normal gall bladder tissue samples, and 5 cystic mucinous hyperplasias of the gall bladder.
  • In all cholangiocellular hyperplasia samples and in all cholangiocellular adenoma samples the benign cholangiocytes showed intense basolateral membrane positivity for claudin-7.
  • Neither the hyperplastic nodules of the liver cells nor the hepatocellular adenomas reacted with claudin-7.
  • The epithelial cells of canine normal extrahepatic bile ducts, gall bladder and cystic mucinous hyperplasias of the gall bladder showed intense basolateral membrane positivity for claudin-7.
  • CONCLUSION: Consequently, we hypothesize that claudin-7 is an excellent immunohistochemical marker of the cholangiocellular differentiation in canines and can be used to detect benign and malignant proliferative lesions of the canine biliary tract.
  • [MeSH-minor] Adenoma, Liver Cell / metabolism. Adenoma, Liver Cell / pathology. Animals. Biliary Tract / metabolism. Biliary Tract / pathology. Case-Control Studies. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / pathology. Claudins. Dogs. Epithelial Cells / metabolism. Epithelial Cells / pathology. Liver / metabolism. Liver / pathology. Neoplasms / metabolism. Neoplasms / pathology. Proteins / metabolism. Tight Junctions / metabolism. Tight Junctions / pathology

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  • (PMID = 20503174.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Claudins; 0 / Proteins
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20. Gütgemann I, Haas S, Berg JP, Zhou H, Büttner R, Fischer HP: CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions. Virchows Arch; 2006 Apr;448(4):407-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions.
  • CD56 (neuronal cell adhesion molecule, N-CAM) has been reported in neuroendocrine tumours and as a marker of reactive biliary epithelial cells.
  • Reactive bile ductules adjacent to cirrhotic nodules as well as in focal nodular hyperplasia were CD56 positive.
  • Twelve of 17 (70.5%) bile duct adenomas were CD56 positive, whereas von Meyenburg complexes expressed CD56 only very focally in less than 5% of lesional cells.
  • Bile duct cysts were negative for CD56 with the exception of focally interspersed neuroendocrine cells, similar to that seen in segmental bile ducts.
  • [MeSH-major] Antigens, CD56 / metabolism. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic / metabolism. Biomarkers, Tumor / metabolism. Cholangiocarcinoma / metabolism. Cholangitis / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma, Bile Duct / diagnosis. Adenoma, Bile Duct / metabolism. Bile Ducts, Extrahepatic / metabolism. Bile Ducts, Extrahepatic / pathology. Choledochal Cyst / diagnosis. Choledochal Cyst / metabolism. Cystadenoma, Mucinous / diagnosis. Cystadenoma, Mucinous / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Liver Cirrhosis / diagnosis. Liver Cirrhosis / metabolism

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  • (PMID = 16411132.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor
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21. Gambarotti M, Medicina D, Baronchelli C, Bercich L, Bonetti F, Facchetti F: Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. Int J Surg Pathol; 2008 Apr;16(2):218-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation.
  • The nodule showed the histological features of a bile duct adenoma.
  • The selective recurrence of large alpha-1-antitrypsin globules within the bile ducts may indicate a neoplastic rather than a reactive or hamartomatous nature of the nodule.
  • [MeSH-major] Adenoma / genetics. Bile Duct Neoplasms / genetics. Bile Ducts, Intrahepatic. Mutation. alpha 1-Antitrypsin / genetics

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  • (PMID = 18417685.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha 1-Antitrypsin
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22. Tajima Y, Tomioka T, Ikematsu Y, Yamanaka S, Kuroki T, Kitajima T, Fukuda K, Tsuneoka N, Kitazato A, Adachi T, Kanematsu T: Experimental study on pathogenesis and histomorphology of early carcinoma of the extrahepatic bile duct in the Syrian hamster. J Exp Clin Cancer Res; 2005 Sep;24(3):475-82
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  • [Title] Experimental study on pathogenesis and histomorphology of early carcinoma of the extrahepatic bile duct in the Syrian hamster.
  • To elucidate the pathogenesis of carcinomas in the extrahepatic bile duct, we investigated the histomorphological characteristics of adenomas and early carcinomas induced in the extrahepatic bile duct of hamsters.
  • Syrian hamsters underwent a cholecystoduodenostomy along with a dissection of the common duct, while also being administered N-nitrosobis(2-oxopropyl)amine (BOP).
  • The tumors that arose from the extrahepatic bile duct included 10 adenomas and 55 early carcinomas in 56 of the 156 hamsters sacrificed.
  • All the adenomas were found to be polypoid in shape.
  • The early carcinomas, which were restricted within the mucosal layer of the bile duct, showed the following three different growth patterns:.
  • Carcinomas existing either alone or associated with adenomas were evident in 12 (22%) tumors, and 11 of these were polypoid.
  • These results support the concept of an adenoma-carcinoma sequence in the majority of polypoid tumors of the extrahepatic bile duct.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology
  • [MeSH-minor] Adenoma / pathology. Animals. Carcinoma / pathology. Cricetinae. Disease Models, Animal. Female. Incidence. Mesocricetus

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  • (PMID = 16270535.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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23. Haas S, Gütgemann I, Wolff M, Fischer HP: Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma. Am J Surg Pathol; 2007 Jun;31(6):902-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clear cell cholangiocarcinoma is a very unusual variant of peripheral bile duct carcinoma.
  • Positive expression of CK7 indicated a cholangiocellular origin.
  • Electronmicroscopy revealed only a few glycogen granula, but numerous cytoplasmic lipoid vacuoles as a possible explanation for the clear cell phenotype.
  • They also show CD56 expression which is a very uncommon finding for intrahepatic cholangiocarcinomas.
  • As CD56 expression is also found in reactive bile ducts and bile duct adenomas, one may speculate that these rare neoplasms may originate from reactive bile ducts or cholangiomatous lesions.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology

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  • (PMID = 17527078.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Keratin-7
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24. Katsinelos P, Paroutoglou G, Kountouras J, Beltsis A, Papaziogas B, Mimidis K, Zavos C, Dimiropoulos S: Safety and long-term follow-up of endoscopic snare excision of ampullary adenomas. Surg Endosc; 2006 Apr;20(4):608-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety and long-term follow-up of endoscopic snare excision of ampullary adenomas.
  • BACKGROUND: Adenomas of the duodenal papilla are rare.
  • The aim of this retrospective study was to evaluate the safety and outcome of endoscopic snare resection of papillary adenomas in a Greek cohort of patients.
  • METHODS: Fourteen patients (six women and eight men; age range, 42-76 years) were referred for endoscopic management of ampullary adenomas.
  • If there was no common bile and main pancreatic duct invasion and the appearance suggested a benign lesion, biductal sphincterotomy onto normal duodenal tissue was performed.
  • The adenomas were resected via a diathermy snare, along with the major papilla, after elevation of the lesion by epinephrine plus dextrose 50% (1:10,000) solution.
  • At the discretion of the endoscopist, a biliary or pancreatic stent was inserted as a prophylactic procedure immediately after excision.
  • RESULTS: Histopathologically, resected tissue included 11 adenomas and three adenomas with focal malignancy, referred for pancreaticoduodenectomy.
  • CONCLUSION: Endoscopic snare resection of adenomas of the major duodenal papilla is a safe, well-tolerated alternative to surgical therapy.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Endoscopy, Digestive System / methods

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  • (PMID = 16508819.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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25. Khan SA, Toledano MB, Taylor-Robinson SD: Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford); 2008;10(2):77-82
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  • Cholangiocarcinoma (CCA) is a fatal cancer of the biliary epithelium, arising either within the liver (intrahepatic, ICC) or in the extrahepatic bile ducts (extrahepatic ECC).
  • These include primary sclerosing cholangitis, liver fluke infestation, congenital fibropolycystic liver, bile duct adenomas, and biliary papillomatosis, hepatolithiasis, chemical carcinogens such as nitrosamines, Thorotrast, chronic viral hepatitis, cirrhosis, chronic non-alcoholic liver disease and obesity.

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  • (PMID = 18773060.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2504381
  • [Keywords] NOTNLM ; Cholangiocarcinoma
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26. Esaki M, Matsumoto T, Yao S, Nakamura S, Hirahashi M, Yao T, Iida M: Immunohistochemical characteristics of duodenal adenomas in familial adenomatous polyposis with special reference to cell kinetics. Hum Pathol; 2005 Jan;36(1):66-73
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  • [Title] Immunohistochemical characteristics of duodenal adenomas in familial adenomatous polyposis with special reference to cell kinetics.
  • The main objective of this study was to evaluate the cell kinetics in duodenal and ampullary adenomas in FAP.
  • The endoscopic and biopsy findings of duodenal adenomas in 22 FAP subjects and 18 non-FAP subjects were compared.
  • Adenomas in FAP included 15 ampullary adenomas and 17 nonampullary adenomas.
  • All 50 adenomas were histologically verified to be tubular adenoma with low-grade dysplasia.
  • In patients with FAP, duodenal adenoma tended to have a higher Ki-67-labeling index than the ampullary adenoma (54.3 +/- 11.3 versus 46.8 +/- 12.7; .05 < P < .1).
  • In addition, the Ki-67-labeling index in endoscopically normal or slightly enlarged ampullary adenoma was significantly higher than that in markedly enlarged ampullary adenoma (51.8 +/- 11.4 versus 39.4 +/- 11.3; P < .05).
  • Duodenal adenoma in FAP subjects was not found to have a higher proliferative activity or a smaller degree of apoptosis compared with those in non-FAP subjects.
  • The smaller proliferative activity in larger ampullary adenoma may thus be related to the static nature of ampullary adenoma in FAP.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Adenomatous Polyposis Coli / complications. Apoptosis / physiology. Duodenal Neoplasms / metabolism. Duodenal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Cell Proliferation. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology. Cyclooxygenase 2. Female. Genes, APC. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Ki-67 Antigen / metabolism. Male. Membrane Proteins. Middle Aged. Mutation. Polymorphism, Single-Stranded Conformational. Prostaglandin-Endoperoxide Synthases / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15712184.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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27. Rossaak J, Bagshaw P, Connor S: Management of Duodenal Adenomas Involving the Ampulla of Vater - A Warning against Limited Resection. Case Rep Gastroenterol; 2008;2(1):96-102

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of Duodenal Adenomas Involving the Ampulla of Vater - A Warning against Limited Resection.
  • Duodenal adenomas are uncommon, however, when present a proportion have dysplasia associated with the adenoma and therefore require treatment.
  • This case report describes two patients with adenomas involving the ampulla of Vater.
  • One patient had familial adenomatous polyposis, the other was a renal transplant patient with a large adenoma.
  • Both patients' adenomas contained high-grade dysplasia.
  • Histology of both specimens demonstrated that the adenoma had migrated up the bile duct for at least 7 mm, and the pancreatic duct for 8 mm in one patient.
  • Limited resection of ampullary adenomas may leave residual adenomatous tissue in the bile duct with the risk of recurrent adenomatous disease and malignant transformation.

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  • (PMID = 21490846.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075174
  • [Keywords] NOTNLM ; Ampullary adenoma/carcinoma / Duodenal adenoma/carcinoma / High-grade dysplasia / Management / Surgery
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28. Kim JH, Kim JH, Han JH, Yoo BM, Kim MW, Kim WH: Is endoscopic papillectomy safe for ampullary adenomas with high-grade dysplasia? Ann Surg Oncol; 2009 Sep;16(9):2547-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is endoscopic papillectomy safe for ampullary adenomas with high-grade dysplasia?
  • OBJECTIVES: This study was designed to provide safe management guidelines for ampullary adenoma by analysis of clinicopathological features.
  • BACKGROUND: The treatment of ampullary cancer has been established; however, the indications for treatment of ampullary adenoma remain controversial.
  • METHODS: Between July 1997 and July 2008, a total of 33 patients were diagnosed with ampullary adenoma prior to procedures: 20 endoscopic papillectomies (ESP), 5 transduodenal resections (TDR), and 8 pancreatoduodenectomies (PD).
  • CONCLUSIONS: Ampullary adenoma with preprocedural HGD was highly associated with coexistence of cancer and recurrence.
  • Therefore, we suggest that ampullary adenoma with preprocedural HGD or more than 1.5 cm should not be managed with endoscopic papillectomy due to high associated rates of recurrence.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Gastrointestinal

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  • (PMID = 19568817.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Schneider AR, Seifert H, Trojan J, Stein J, Hoepffner NM: Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study. Z Gastroenterol; 2005 Oct;43(10):1123-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study.
  • METHODS: 26 consecutive patients (16 women, 10 men; median age 59 years) with sporadic adenomas (n = 19) or adenocarcinomas (n = 7) of the ampulla of Vater were retrospectively evaluated.
  • However, the finding of 2 rectal carcinomas among patients with ampullary neoplasms supports the place of screening colonoscopy for the diagnostic work-up of ampullary tumors.
  • [MeSH-major] Adenocarcinoma / complications. Adenoma / complications. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Intestinal Polyps / epidemiology
  • [MeSH-minor] Adenoma, Villous / complications. Adenoma, Villous / surgery. Adenomatous Polyposis Coli / epidemiology. Adult. Aged. Aged, 80 and over. Colonic Polyps / diagnosis. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Risk Factors. Time Factors

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  • (PMID = 16220451.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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30. Hamberger C, Kellert M, Schauer UM, Dekant W, Mally A: Hepatobiliary toxicity of furan: identification of furan metabolites in bile of male f344/n rats. Drug Metab Dispos; 2010 Oct;38(10):1698-706
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  • [Title] Hepatobiliary toxicity of furan: identification of furan metabolites in bile of male f344/n rats.
  • In a 2-year bioassay, furan caused hepatocellular adenomas and carcinomas in mice and rats but also high incidences of bile duct tumors in rats.
  • The objective of this study was to structurally characterize furan metabolites excreted with bile to better understand the potential role of reactive furan intermediates in the biliary toxicity of furan.
  • Bile duct-cannulated F344/N rats (n = 3) were administered a single oral dose of 5 mg/kg b.wt.
  • [(12)C(4)]furan or stable isotope-labeled [3,4-(13)C]furan, and bile samples collected at 30-min intervals for 4 h were analyzed by liquid chromatography-tandem mass spectrometry.
  • A total of eight furan metabolites derived from reaction of cis-2-butene-1,4-dial with GSH and/or amino acids and subsequent enzymatic degradation were detected in bile.
  • [MeSH-major] Aldehydes / metabolism. Bile / metabolism. Bile Ducts / drug effects. Biliary Tract Diseases / chemically induced. Drug-Induced Liver Injury / etiology. Furans / toxicity

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  • (PMID = 20639435.001).
  • [ISSN] 1521-009X
  • [Journal-full-title] Drug metabolism and disposition: the biological fate of chemicals
  • [ISO-abbreviation] Drug Metab. Dispos.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Furans; 2363-83-9 / malealdehyde; GAN16C9B8O / Glutathione; TE7660XO1C / Glycine; UC0XV6A8N9 / furan
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31. Rautou PE, Lévy P, Vullierme MP, O'Toole D, Couvelard A, Cazals-Hatem D, Palazzo L, Aubert A, Sauvanet A, Hammel P, Hentic O, Rebours V, Pelletier AL, Maire F, Ruszniewski P: Morphologic changes in branch duct intraductal papillary mucinous neoplasms of the pancreas: a midterm follow-up study. Clin Gastroenterol Hepatol; 2008 Jul;6(7):807-14
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  • [Title] Morphologic changes in branch duct intraductal papillary mucinous neoplasms of the pancreas: a midterm follow-up study.
  • The aim of this study was to assess time-related morphologic changes and risk of progress to malignancy in patients with BD IPMN.
  • METHODS: All consecutive patients seen from 1999 to 2005 with highly suspected IPMNs confined to BD without criteria suggesting a malignant development (mural nodule, cyst wall thickness >2 mm, BD diameter >30 mm, or main pancreatic duct involvement) were followed up prospectively using computerized tomography, magnetic resonance cholangiopancreatography, and endoscopic ultrasonography.
  • After a median follow-up period of 33 months, no morphologic changes had occurred in 88 patients.
  • Surgery, performed in 8 of 12 patients, found 4 IPMN-adenomas, 1 borderline-IPMN, and 4 IPMN carcinoma in situ.
  • CONCLUSIONS: In patients with IPMNs confined to BD, morphologic changes are rare events, justifying a nonsurgical approach.
  • [MeSH-minor] Adult. Aged. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct / pathology. Cysts / pathology. Disease Progression. Endosonography. Female. Follow-Up Studies. Hospitals, University. Humans. Male. Middle Aged. Prospective Studies. Radiography, Abdominal. Tomography, X-Ray Computed. Treatment Outcome

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  • [CommentIn] Clin Gastroenterol Hepatol. 2008 Jul;6(7):724-5 [18602034.001]
  • (PMID = 18304885.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Alvaro D, Cannizzaro R, Labianca R, Valvo F, Farinati F, Italian Society of Gastroenterology (SIGE), Italian Association of Hospital Gastroenterology (AIGO), Italian Association of Medical Oncology (AIOM), Italian Association of Oncological Radiotherapy (AIRO): Cholangiocarcinoma: A position paper by the Italian Society of Gastroenterology (SIGE), the Italian Association of Hospital Gastroenterology (AIGO), the Italian Association of Medical Oncology (AIOM) and the Italian Association of Oncological Radiotherapy (AIRO). Dig Liver Dis; 2010 Dec;42(12):831-8
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  • The incidence of Cholangiocellular carcinoma (CCA) is increasing, due to a sharp increase of the intra-hepatic form.
  • Evidence-ascertained risk factors for CCA are primary sclerosing cholangitis, Opistorchis viverrini infection, Caroli disease, congenital choledocal cist, Vater ampulla adenoma, bile duct adenoma and intra-hepatic lithiasis.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / therapy. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy

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  • [Copyright] Copyright © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20702152.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] Netherlands
  • [Investigator] Avuzzi B; Buscarini E; Fornasarig M; Iacono C; Maiero S; Mosconi S; Muto P; Tasca C; Vanin V
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33. Sohn VY, Arthurs ZM, Martin MJ, Sebesta JA, Branch JB, Champeaux AL: Incidental pathologic findings in open resectional gastric bypass specimens with routine cholecystectomy and appendectomy. Surg Obes Relat Dis; 2008 Sep-Oct;4(5):608-11
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  • This procedure allows for pathologic assessment of otherwise normal viscera routinely removed as a part of the gastric bypass.
  • In the gallbladder the sole abnormality, other than cholelithiasis, was an adenomyoma.
  • Other resected findings included five Meckel's diverticula, one bile duct adenoma, and one sigmoid diverticulum.

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  • (PMID = 18586563.001).
  • [ISSN] 1550-7289
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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34. Targarona Modena J, Rosamedina JL, Garatea R, Romero C, Lora A, Contardo C, Mantila L, Yabar A, Montoya E: [Transduodenal ampullectomy: an useful alternative for the treatment of Vater's ampulla lesions. Case reports of an unfrecuent surgical technique]. Rev Gastroenterol Peru; 2005 Jan-Mar;25(1):106-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Ampulectomía transduodenal una alternativa útil para el tratamiento de las lesiones de la ampolla de Vater: reporte de casos de una técnica raramente utilizada.
  • The ampullectomy consists on the total resection of the Vater's ampulla and part of the duodenal wall with the later reconstruction and anastomosis of the common bile duct and the Wirsung's duct to the duodenum.
  • The local resection of the ampulla is an alternative to the duodenopancreatectomy that has to be taken into account, especially in benign lesions as in the case of adenomas of the Vater's ampulla.
  • Here we describe two cases one with adenoma of the Vater's ampulla, with a high degree dysplasia, who first underwent an ampullectomy and finally ended up in a duodenopancreatectomy due to the infiltration of the adenoma into the edge of section and other case of Lymphangioma of Vater's ampulla with no infiltration in the edge of section.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery

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  • (PMID = 15818426.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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35. Ruemmele P, Dietmaier W, Terracciano L, Tornillo L, Bataille F, Kaiser A, Wuensch PH, Heinmoeller E, Homayounfar K, Luettges J, Kloeppel G, Sessa F, Edmonston TB, Schneider-Stock R, Klinkhammer-Schalke M, Pauer A, Schick S, Hofstaedter F, Baumhoer D, Hartmann A: Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol; 2009 May;33(5):691-704
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  • We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of MMR proteins and specific histopathologic features.
  • Eight of 89 adenomas (9%) and 15/144 carcinomas (10%) showed high microsatellite instability (MSI-H), 10/89 adenomas (11%) and 5/144 carcinomas (4%) showed low microsatellite instability (MSI-L), and 71/89 adenomas (80%) and 124/144 carcinomas (86%) were microsatellite stable (MSS).
  • Two carcinomas and 3 adenomas with MSI-H revealed exclusive loss of MSH6.
  • Our findings indicate that the MSI-phenotype is an early event, which develops at the stage of adenoma and is reliably detectable in the precursor lesion.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater / pathology. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair. Gene Expression Regulation, Neoplastic. Microsatellite Instability. Precancerous Conditions / pathology

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  • (PMID = 19252434.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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36. Ouaïssi M, Sielezneff I, Alves A, Pirro N, Heyries L, Robitail S, Consentino B, Payan MJ, Valleur P, Panis Y, Sastre B: [Long term outcome following 26 surgical ampullectomies]. Ann Chir; 2006 May;131(5):322-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Résultat à long terme de 26 ampullectomies chirurgicales.
  • Ampullectomy is an alternative to PD for benign ampulloma or, in high-risk patients, for invasive carcinoma.
  • The aim of this study was to report early and long term results of surgical ampullectomy for presumed benign ampullomas.
  • RESULTS: Final pathological examination revealed 15 adenomas, 4 in situ adenocarcinomas, 2 endocrine tumors, and 5 other benign lesions.
  • Four patients died during follow-up (including 3 from initial disease).
  • CONCLUSION: Ampullectomy is a good alternative to PD in case of benign or non-invasive malignant ampullary lesion, including in selected cases of FAP.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Adenomatous Polyposis Coli / surgery. Adult. Aged. Carcinoma in Situ / surgery. Cause of Death. Common Bile Duct Diseases / surgery. Female. Follow-Up Studies. Granuloma, Plasma Cell / surgery. Humans. Longitudinal Studies. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Retrospective Studies. Somatostatinoma / surgery. Survival Rate. Treatment Outcome

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  • (PMID = 16615931.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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37. Bulat C, Bîşca L, Stoian M: [Tumors of the ampulla of Vater--local or radical resection?]. Rev Med Chir Soc Med Nat Iasi; 2006 Jul-Sep;110(3):609-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Duodenal ampulla is a complex anatomical and histological site and a tumor may arise from one of three types of epithelium: duodenal mucosa, pancreatic duct and distal common bile duct.
  • Benign adenomas appear to be a frequent precursor of carcinoma of the ampulla of Vater, therefore, a local resection can lead to an under treated early cancer which would have benefited from a radical excision, with a much better long term result.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery

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  • (PMID = 17571553.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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38. Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC: Prevalence and risk factors for gallbladder neoplasia in patients with primary sclerosing cholangitis: evidence for a metaplasia-dysplasia-carcinoma sequence. Am J Surg Pathol; 2007 Jun;31(6):907-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dysplasia, adenomas, and carcinomas of the gallbladder have been described in PSC but are less common than bile duct carcinomas.
  • (1) sex, (2) age, (3) PSC duration, (4) inflammatory bowel disease (IBD) at time of OLT, and (5) concomitant bile duct dysplasia or carcinoma.
  • Gallbladder carcinoma was associated with intrahepatic bile duct dysplasia (P=0.001), CC (P=0.023), and IBD (P=0.03).
  • Gallbladder dysplasia was associated with hilar/intrahepatic bile duct dysplasia (P=0.0006), CC (P=0.028), IBD (P=0.0014), and older age at OLT (P=0.007).
  • The strong correlation between gallbladder dysplasia/adenocarcinoma and bile duct dysplasia/CC supports the concept of a neoplastic "field effect" along the intrahepatic and extrahepatic biliary tract in PSC.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Bile Duct Neoplasms / pathology. Bile Ducts / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Female. Humans. Liver Transplantation. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Precancerous Conditions / epidemiology. Precancerous Conditions / pathology. Prevalence. Risk Factors

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  • (PMID = 17527079.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Nuernberg D, Ignee A, Dietrich CF: [Ultrasound in gastroenterology. Biliopancreatic system]. Med Klin (Munich); 2007 Feb 15;102(2):112-26
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  • GALLBLADDER: Ultrasound has become widely accepted for the diagnosis of gallbladder disease.
  • An obstruction of the bile ducts and its localization are easily recognized.
  • Adenomas of > 1 cm are an indication for surgery, the detection of a vessel at the polyps' base by color duplex ultrasound is helpful.
  • Gallbladder carcinomas as a disease of the older age with few early symptoms are usually detected at a late stage when the liver is already infiltrated.
  • BILE DUCT SYSTEM: Even with the most modern equipment the sensitivity for choledocholithiasis is still largely dependent on the examiner's expertise und differs between 25% and 100%.
  • Primary sclerosing cholangitis shows bile duct dilation like "a string of pearls" and typical perihepatic lymph node enlargement.
  • PANCREAS: In diagnostic imaging of the pancreas ultrasound stands at the beginning of a diagnostic cascade.
  • Ductal adenocarcinoma seems to be less vascularized in comparison to the surrounding tissue, while endocrine tumors and macro- and microcystic adenoma are rather hypervascularized.
  • [MeSH-minor] Adenoma / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic / ultrasonography. Carcinoma / ultrasonography. Cholangiocarcinoma / ultrasonography. Cholangitis, Sclerosing / ultrasonography. Cholecystitis / ultrasonography. Choledocholithiasis / ultrasonography. Contrast Media. Diagnosis, Differential. Endosonography. Gallbladder Neoplasms / ultrasonography. Humans. Middle Aged. Pancreatic Neoplasms / ultrasonography. Pancreatitis / ultrasonography. Polyps / ultrasonography. Sensitivity and Specificity. Ultrasonography, Doppler, Color / methods

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  • (PMID = 17323018.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 228
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40. Hernandez LV, Catalano MF: Endoscopic papillectomy. Curr Opin Gastroenterol; 2008 Sep;24(5):617-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In 2006, a consensus guideline was published by the American Society of Gastrointestinal Endoscopy evaluating the role of endoscopy in managing ampullary adenomas.
  • Also, a randomized controlled trial has shown that the use of pancreatic duct stents is associated with less incidence of postendoscopic papillectomy pancreatitis, although the study was probably underpowered.
  • Several methods can be used to help locate the pancreatic duct postendoscopic papillectomy (endoscopic ultrasound-guided rendezvous and methylene blue injection).
  • [MeSH-major] Ampulla of Vater / surgery. Cholangiopancreatography, Endoscopic Retrograde / methods. Common Bile Duct Neoplasms / surgery. Endoscopy / methods

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  • (PMID = 19122504.001).
  • [ISSN] 1531-7056
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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41. Li T, Fan J, Hu SY, Tang ZY, Zhi XT: [A clinicopathologic study of biliary intraductal papillary neoplasm]. Zhonghua Wai Ke Za Zhi; 2010 Apr 1;48(7):488-91
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  • The average diameter of the tumors was (6 +/- 4) cm, 4 lesions were located in the right lobe, 15 in the left lobe, and 4 in the extrahepatic bile duct.
  • Histopathologically, there were 4 adenomas, 1 borderline neoplasm, 6 carcinomas in situ, and 12 carcinomas.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Carcinoma, Papillary / pathology

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  • (PMID = 20646655.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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42. Eswaran SL, Sanders M, Bernadino KP, Ansari A, Lawrence C, Stefan A, Mattia A, Howell DA: Success and complications of endoscopic removal of giant duodenal and ampullary polyps: a comparative series. Gastrointest Endosc; 2006 Dec;64(6):925-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Increasing reports suggest that endoscopic removal of benign ampullary and duodenal polyps is safe and frequently definitive; however, most reported polyps have been small in size (<3 cm).
  • When the ampulla was involved, biductal sphincterotomy and prophylactic pancreatic duct stent placement was performed first, followed by saline solution-assisted piecemeal polypectomy, argon plasma coagulation, selective endoclip placement, and recovery of all polyp fragments.
  • INTERVENTIONS: Endoscopic removal of duodenal and ampullary adenomas.
  • RESULTS: The outcomes of small and large adenoma removal include mean number of endoscopic retrograde cholangiopancreatographies required for complete removal (2.09 vs 2.56, P = .392), number of complications (4.5% vs 13.9%, P = .375), discovery of unsuspected cancer (0% vs 10.3%, P = .242), and final definitive resolution (100% vs 86.2%, P = .124).
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Endoscopy, Digestive System / methods. Polyps / surgery

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  • (PMID = 17140900.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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43. Yamao T, Isomoto H, Kohno S, Mizuta Y, Yamakawa M, Nakao K, Irie J: Endoscopic snare papillectomy with biliary and pancreatic stent placement for tumors of the major duodenal papilla. Surg Endosc; 2010 Jan;24(1):119-24

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  • BACKGROUND: This study aimed to evaluate the feasibility, safety, and follow-up results of endoscopic papilletomy (ESP) with pancreatic and biliary duct stent placement for ampullary tumors.
  • The therapeutic approach to benign ampullary tumors remains unsettled.
  • The ESP procedure is a curative treatment option for benign papillary tumors, but ESP raises concerns about a relatively high risk for procedure-related complications such as pancreatitis.
  • There were 26 adenomas including 4 high-grade intraepithelial neoplasias (HGINs), 5 carcinomas in adenoma, and 3 intramucosal cancers.
  • During the median follow-up period of 14 months, there was one recurrent adenoma, which was successfully eradicated by a repeat ESP.
  • CONCLUSION: The ESP procedure can be feasible for benign ampullary adenoma, HGIN, and noninvasive cancer without intraductal tumor growth.
  • Prophylactic stent placement in the pancreatic and bile ducts may reduce procedure-related complications.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenoscopy

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  • (PMID = 19517183.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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44. Yamazaki S, Takayama T, Watanabe Y, Oikawa T, Hayashi Y, Kochi M, Moriguchi M, Higaki T, Inoue K: Imaging modality of three-dimensional CT in caudate cholangioma: assessment for resectability. Hepatogastroenterology; 2007 Mar;54(74):397-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging modality of three-dimensional CT in caudate cholangioma: assessment for resectability.
  • Conventional preoperative imaging has limited modality and accuracy in primary intrahepatic cholangiocellular carcinoma (ICC) in the caudate lobe (CL).
  • His lesion was judged unresectable hilar cholangiocellular carcinoma because it had spread widely to the bilateral lobe of the liver as shown by preoperative imaging studies.
  • The left lobe showed marked atrophy and intrahepatic biliary duct (IHBD) dilatation of the whole liver was observed.
  • [MeSH-major] Bile Duct Neoplasms / radiography. Bile Ducts, Intrahepatic / radiography. Cholangiocarcinoma / radiography. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Tomography, Spiral Computed

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  • (PMID = 17523283.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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45. Sperti C, Pasquali C, Fiore V, Bissoli S, Chierichetti F, Liessi G, Pedrazzoli S: Clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the management of patients with nonpancreatic periampullary neoplasms. Am J Surg; 2006 Jun;191(6):743-8
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  • RESULTS: Between January 1998 and December 2003, 14 ampullary, 7 bile duct, and 4 duodenal tumors were included in the study.
  • PET showed increased focal uptake in 22 patients (88%): 11 of 14 (79%) ampullary tumors, and 100% of bile duct and duodenal tumors.
  • An SUV value of 2.7 discriminated adenomas or noninvasive cancers (n = 6) from invasive malignancies (n = 14).
  • Follow-up evaluation including CT scan and PET was performed in 12 patients: PET showed recurrent disease not seen by CT in 4 patients, confirmed CT findings in 6 patients, and showed an unsuspected primary lung cancer in 1 patient and colon cancer in another patient.
  • It may be useful to differentiate benign or borderline lesions from invasive tumors when no mass has been identified by traditional imaging.
  • Finally, it is very useful in the follow-up evaluation of resected patients to identify recurrent disease or other malignancies.
  • [MeSH-major] Ampulla of Vater / radionuclide imaging. Bile Duct Neoplasms / radionuclide imaging. Duodenal Neoplasms / radionuclide imaging. Pancreatic Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 16720142.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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46. Hohmann J, Loddenkemper C, Albrecht T: Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents. Ultraschall Med; 2009 Apr;30(2):185-8
Hazardous Substances Data Bank. SULFUR HEXAFLUORIDE .

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  • [Title] Assessment of a biliary hamartoma with contrast-enhanced sonography using two different contrast agents.
  • Low-MI contrast-enhanced ultrasound (CEUS) with SonoVue (Bracco, Milano, Italy) showed an enhancement pattern which was typical for benign liver lesions while high-MI CEUS with Levovist (Schering, Berlin, Germany) revealed a contrast defect in the liver late phase (4:30 min p. i.) which is typical for a malignant lesion.
  • Due to these findings the lesion was evaluated as a potentially malignant lesion and a biopsy was performed.
  • Histology showed a benign biliary hamartoma and incomplete cirrhosis.
  • The findings confirmed that liver-specific contrast agents have the ability to detect very small focal liver lesions not derived from hepatic tissue but may lead to a misinterpretation as a malignant lesion.
  • Nevertheless biliary duct adenomas are benign lesions with almost the same perfusion properties as normal liver parenchyma.
  • [MeSH-major] Adenoma, Bile Duct / ultrasonography. Bile Duct Diseases / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic / ultrasonography. Contrast Media. Hamartoma / ultrasonography. Phospholipids. Polysaccharides. Sulfur Hexafluoride. Ultrasonography, Doppler, Duplex

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  • (PMID = 18726842.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Phospholipids; 0 / Polysaccharides; 0 / contrast agent BR1; 127279-08-7 / SHU 508; WS7LR3I1D6 / Sulfur Hexafluoride
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47. Dixon E, Vollmer CM Jr, Sahajpal A, Cattral MS, Grant DR, Taylor BR, Langer B, Gallinger S, Greig PD: Transduodenal resection of peri-ampullary lesions. World J Surg; 2005 May;29(5):649-52
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  • From 1992 to 2002, 19 patients with an average age of 64.2 years (range: 33-84 years) underwent a transduodenal resection of a peri-ampullary lesion; median follow-up was 47 months (range: 2-100 months).
  • Pathology of the lesions was as follows: 11 with benign ampullary adenomas, including 4 with familial adenomatous polyposis (FAP); 7 with peri-ampullary adenocarcinomas; and 1 with a benign stricture.
  • Transduodenal resection of peri-ampullary lesions appears to be a safe alternative to radical resection for benign adenomas and selected carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Digestive System Surgical Procedures

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  • (PMID = 15827855.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Gray MN, Aylward LL, Keenan RE: Relative cancer potencies of selected dioxin-like compounds on a body-burden basis: comparison to current toxic equivalency factors (TEFs). J Toxicol Environ Health A; 2006 May;69(10):907-17
Hazardous Substances Data Bank. 2,3,4,7,8-PENTACHLORODIBENZOFURAN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Poly-3 adjusted tumor incidences for hepatocellular adenomas, cholangiocarcinomas, and the two tumors combined were modeled using a quantal multistage model and the Hill model with lifetime average body burden as the dose metric.
  • [MeSH-major] Adenoma, Liver Cell / chemically induced. Benzofurans / adverse effects. Cholangiocarcinoma / chemically induced. Digestive System Neoplasms / chemically induced. Polychlorinated Biphenyls / adverse effects. Tetrachlorodibenzodioxin / adverse effects
  • [MeSH-minor] Adipose Tissue / chemistry. Animals. Bile Duct Neoplasms / chemically induced. Bile Ducts, Intrahepatic. Body Burden. Carcinogenicity Tests. Humans. Liver / chemistry. Liver Neoplasms / chemically induced. Lung / chemistry. Models, Biological. Organ Size. Risk Assessment

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  • (PMID = 16728370.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzofurans; DFC2HB4I0K / Polychlorinated Biphenyls; DO80M48B6O / Tetrachlorodibenzodioxin; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl; U4C2RV3124 / 2,3,4,7,8-pentachlorodibenzofuran
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49. Karlsen TH, Schrumpf E, Boberg KM: Gallbladder polyps in primary sclerosing cholangitis: not so benign. Curr Opin Gastroenterol; 2008 May;24(3):395-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder polyps in primary sclerosing cholangitis: not so benign.
  • In several studies, foci of dysplasia were also detected in separate adenomas and regions of the gallbladder not primarily affected by cancer.
  • Concurrent dysplasia and malignancies of the bile ducts and colon have also been reported, and suggest that an increased awareness of malignancy is warranted in patients once gallbladder neoplasia has been detected.
  • Cholecystectomy and intensified screening for dysplasia of the bile ducts and colon may be advisable in primary sclerosing cholangitis patients with neoplasia of the gallbladder.
  • [MeSH-minor] Bile Duct Neoplasms / complications. Cholangiocarcinoma / complications. Humans

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  • (PMID = 18408471.001).
  • [ISSN] 1531-7056
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 65
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50. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 May;(529):4-168
Hazardous Substances Data Bank. 2,2',4,4',5,5'-HEXACHLOROBIPHENYL .

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  • Since human exposure to DLCs always involves a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.
  • PCB 153 was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs).
  • The incidences of diffuse fatty change in the 300 microg/kg or greater groups and bile duct hyperplasia of the liver in 300 microg/kg and 3,000 microg/kg (core and stop-exposure) groups were significantly increased.
  • At 2 years, two cholangiomas were seen in the 1,000 microg/kg group and two cholangiomas were seen in the 3,000 microg/kg stop-exposure group.
  • A single hepatocellular adenoma was observed in the 3,000 microg/kg core study group.
  • CONCLUSIONS: Under the conditions of this 2-year gavage study there was equivocal evidence of carcinogenic activity of PCB 153 in female Harlan Sprague-Dawley rats based on the occurrences of cholangioma of the liver.
  • [MeSH-major] Bile Ducts, Intrahepatic / pathology. Carcinogens / toxicity. Polychlorinated Biphenyls / toxicity
  • [MeSH-minor] Adenoma, Bile Duct / chemically induced. Adenoma, Bile Duct / pathology. Administration, Oral. Animals. Bile Duct Neoplasms / chemically induced. Bile Duct Neoplasms / pathology. Cell Enlargement / drug effects. Cell Proliferation / drug effects. Dose-Response Relationship, Drug. Female. Hepatocytes / drug effects. Hepatocytes / pathology. Liver / drug effects. Liver / pathology. Organ Size / drug effects. Rats. Rats, Sprague-Dawley. Thyroid Hormones / blood. Toxicity Tests

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  • (PMID = 16835634.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Thyroid Hormones; DFC2HB4I0K / Polychlorinated Biphenyls; ZRU0C9E32O / 2,4,5,2',4',5'-hexachlorobiphenyl
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51. Park S, Kim SW, Lee BL, Jung EJ, Kim WH: Expression of E-cadherin and beta-catenin in the adenoma-carcinoma sequence of ampulla of Vater cancer. Hepatogastroenterology; 2006 Jan-Feb;53(67):28-32
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of E-cadherin and beta-catenin in the adenoma-carcinoma sequence of ampulla of Vater cancer.
  • BACKGROUND/AIMS: Ampullary carcinoma is uncommon but provides a good model for adenoma-carcinoma sequence.
  • During the adenoma-carcinoma transition, the tumor cells should acquire the ability to invade.
  • RESULTS: Expressional loss of E-cadherin was detected in 3 (6.1%) adenomas and 73 (65.8%) carcinomas, and the expressional loss was significantly associated with tumor cell differentiation (p<0.05) and survival (p<0.05) in carcinoma.
  • In beta-catenin immunostaining, 4 (8.2%) adenomas and 45 (40.5%) carcinomas showed abnormal staining patterns either as nuclear staining or as a loss of membrane staining.
  • CONCLUSIONS: Alteration of E-cadherin and beta-catenin is a late event during the adenoma-carcinoma sequence in ampullary neoplasms, and the loss of membranous expression of both E-cadherin and beta-catenin is closely correlated with less differentiated histology and poor prognosis.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Ampulla of Vater. Cadherins / biosynthesis. Carcinoma / metabolism. Carcinoma / pathology. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology. beta Catenin / biosynthesis

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  • (PMID = 16506371.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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52. Kobuke T, Tazuma S, Hyogo H, Chayama K: A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: potential molecular targeting strategy for cholangioma. Dig Dis Sci; 2006 Sep;51(9):1650-7
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  • [Title] A Ligand for peroxisome proliferator-activated receptor gamma inhibits human cholangiocarcinoma cell growth: potential molecular targeting strategy for cholangioma.
  • PPAR( expression in HuH-28 and HuCCT1 cells (intrahepatic bile duct carcinoma) was determined using the reverse transcription-polymerase chain reaction (RT-PCR).
  • [MeSH-minor] Bile Duct Neoplasms / enzymology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / enzymology. Bile Ducts, Intrahepatic / pathology. Caspase 3. Caspase 9. Caspases / metabolism. Cell Culture Techniques. Cell Line, Tumor. Cell Proliferation / drug effects. Humans. Ligands. Molecular Biology. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16927143.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Chromans; 0 / Ligands; 0 / PPAR gamma; 0 / RNA, Neoplasm; 0 / Thiazolidinediones; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases; I66ZZ0ZN0E / troglitazone; X4OV71U42S / pioglitazone
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53. Lozoya-González D, Farca-Belsaguy A, Peláez-Luna M, Vázquez-Ballesteros E, González-Galeote E, Salceda-Otero JC: [Endoscopic resection of ampullary adenoma.]. Rev Gastroenterol Mex; 2010;75(1):89-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endoscopic resection of ampullary adenoma.].
  • [Transliterated title] Resección endoscópica de adenoma del ámpula de Vater.
  • Ampullary adenomas can occur sporadically or as part of familial adenomatous polyposis syndrome.
  • We present the case of a patient with an ampulla of Vater s adenoma successfully resected endoscopically previous assessment of the lesion by endoscopic ultrasound.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Endoscopy, Digestive System

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  • (PMID = 20423788.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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54. Legler M, Kothe R, Rautenschlein S, Kummerfeld N: [Detection of psittacid herpesvirus 1 in Amazon parrots with cloacal papilloma (internal papillomatosis of parrots, IPP) in an aviary of different psittacine species]. Dtsch Tierarztl Wochenschr; 2008 Dec;115(12):461-70

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  • Hepatomegaly was detected in the radiographs of the clinically diseased amazon parrots, indicating the involvement of the liver in the disease process.
  • One of the amazons had an increased level of bile acids in the plasma supporting the suspicion of the involvement of the liver.
  • Macroscopical and histological investigation of amazons with cloacal prolaps revealed a papillomic adenoma of the cloacal mucosa accompanied by varying degrees of bile duct carcinomas in the liver and adenocarcinomas of the pancreas.
  • We may speculate that there is correlation between the infection with PsHV-1 and the development of cloacal adenomas, adenocarcinomas in the pancreas and carcinomas of the bile ducts.
  • A therapy approach with the immunomodulator Imiquimod did not improve the clinical disease of the birds, although circulating interferon levels were detected in serum samples of treated birds.

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  • (PMID = 19113029.001).
  • [ISSN] 0341-6593
  • [Journal-full-title] DTW. Deutsche tierärztliche Wochenschrift
  • [ISO-abbreviation] DTW. Dtsch. Tierarztl. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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55. Hwang JC, Kim JH, Lim SG, Yoo BM, Cho SW: Endoscopic resection of ampullary adenoma after a new insulated plastic pancreatic stent placement: a pilot study. J Gastroenterol Hepatol; 2010 Aug;25(8):1381-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of ampullary adenoma after a new insulated plastic pancreatic stent placement: a pilot study.
  • METHODS: We conducted a prospective pilot study involving 11 consecutive patients with adenomas of the major duodenal papilla.
  • CONCLUSIONS: Pre-resection stenting with a polytetrafluoroethylene-insulated stent in patients with adenomas of the major duodenal papilla is a feasible and useful technique to prevent pancreatitis.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Pancreatitis / prevention & control. Polytetrafluoroethylene. Sphincterotomy, Endoscopic. Stents

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  • [CommentIn] J Gastroenterol Hepatol. 2010 Aug;25(8):1338-9 [20659220.001]
  • (PMID = 20659227.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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56. Greco S, Cassinotti A, Massari A, Bossi I, Trabucchi E, Bianchi Porro G: Isolated ampullary adenoma causing biliary obstruction. J Gastrointestin Liver Dis; 2008 Sep;17(3):329-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated ampullary adenoma causing biliary obstruction.
  • This is an interesting case of an isolated ampullary adenoma causing biliary obstruction that required surgical excision.
  • We describe a patient who presented with a six month history of recurrent attacks of typical biliary pain radiating from the right upper quadrant of the abdomen to the back, nausea and vomiting, which we attributed to a large pedunculated tubulovillous adenoma.
  • Abdominal ultrasound and endoscopic ultrasonography provided useful information in the diagnostic assessment of ampullary adenoma.
  • Sporadic duodenal adenomas are an increasingly recognized condition in those with familial adenomatous polyposis syndromes as well as sporadic cases.
  • [MeSH-major] Adenoma / complications. Ampulla of Vater. Cholestasis / etiology. Common Bile Duct Neoplasms / complications

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  • (PMID = 18836629.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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57. Uchiyama Y, Imazu H, Kakutani H, Hino S, Sumiyama K, Kuramochi A, Tsukinaga S, Matsunaga K, Nakayoshi T, Goda K, Saito S, Kaise M, Kawamuara M, Omar S, Tajiri H: New approach to diagnosing ampullary tumors by magnifying endoscopy combined with a narrow-band imaging system. J Gastroenterol; 2006 May;41(5):483-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the present study, we investigated the ability of magnifying endoscopy with NBI (MENBI) to diagnose and differentiate between benign and malignant ampullary tumors.
  • MENBI findings were classified as I, oval-shaped villi; II, pinecone/leaf-shaped villi; or III, irregular/nonstructured.
  • All adenomas and adenocarcinomas had type II and/or type III surface structures, and patients whose ampulla had a type I surface structure had only inflammatory or hyperplastic changes.
  • In addition, abnormal vessels were seen only in adenocarcinomas and never in adenomas.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / pathology. Adenoma / surgery. Aged. Biopsy. Female. Follow-Up Studies. Humans. Inflammation. Male. Microscopy, Video. Middle Aged. Retrospective Studies

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  • (PMID = 16799891.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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58. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today; 2008;38(5):440-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
  • Upper endoscopy showed multiple duodenal adenomas including carcinoma involving the papilla of Vater.
  • To remove these duodenal adenomas and ampullary carcinoma and prevent recurrent pancreatitis, we performed pancreaticoduodenectomy.
  • On pathologic examination, the major duodenal papilla was completely obstructed by the carcinoma, and the minor papilla was also involved by the adenoma.
  • The patient has no evidence of disease and has experienced no pancreatitis in 3 years of follow-up.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications. Ampulla of Vater. Common Bile Duct Neoplasms / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / etiology


59. Bohnacker S, Soehendra N, Maguchi H, Chung JB, Howell DA: Endoscopic resection of benign tumors of the papilla of vater. Endoscopy; 2006 May;38(5):521-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of benign tumors of the papilla of vater.
  • Most benign papillary tumors are adenomas which can potentially undergo the adenoma-carcinoma-sequence making complete removal mandatory for curative therapy.
  • Endoscopic resection (papillectomy) of these lesions is being increasingly performed as a less traumatic alternative to surgery.
  • Endoscopic snare resection of entire lesions should be primarily regarded as a diagnostic procedure.
  • For benign looking papillary tumors, endoscopic papillectomy serves as a diagnostic tool and should be considered as first line procedure regardless of age.
  • The following article details the approach to patients with benign papillary tumor and the technique of endoscopic papillectomy.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods

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  • (PMID = 16767591.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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60. Verslype C, Libbrecht L: The multidisciplinary management of gastrointestinal cancer. The diagnostic and therapeutic approach for primary solid liver tumours in adults. Best Pract Res Clin Gastroenterol; 2007;21(6):983-96
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  • The finding of a focal solid liver lesion represents a challenge for the clinician in terms of the most optimal diagnostic and therapeutic algorithm.
  • Tumours may arise from hepatocytes (hepatocellular adenoma, dysplastic nodules and carcinoma), bile ducts (cholangiocarcinoma) or mesenchymal tissue (hemangioma, epithelioid haemangioendothelioma), or are metastases from primary tumours outside the liver.
  • More insight has been gathered recently in the histological classification of hepatocellular adenomas, but the differential diagnosis by imaging of adenoma versus FNH or well-differentiated hepatocellular carcinoma remains often difficult.
  • The therapy of a focal liver lesion is determined by its natural history and the functional status of the surrounding liver parenchyma.
  • [MeSH-major] Bile Duct Neoplasms. Liver Cirrhosis / complications. Liver Neoplasms. Precancerous Conditions
  • [MeSH-minor] Adenoma, Liver Cell / diagnosis. Adenoma, Liver Cell / etiology. Adenoma, Liver Cell / therapy. Adult. Bile Ducts, Intrahepatic / pathology. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / etiology. Carcinoma, Hepatocellular / therapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / etiology. Cholangiocarcinoma / therapy. Diagnosis, Differential. Focal Nodular Hyperplasia / diagnosis. Focal Nodular Hyperplasia / etiology. Focal Nodular Hyperplasia / therapy. Hemangioma / diagnosis. Hemangioma / etiology. Hemangioma / therapy. Humans

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  • (PMID = 18070699.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 47
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61. Baumhoer D, Riener MO, Zlobec I, Tornillo L, Vogetseder A, Kristiansen G, Dietmaier W, Hartmann A, Wuensch PH, Sessa F, Ruemmele P, Terracciano LM: Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater. Mod Pathol; 2009 Feb;22(2):306-13
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  • Carcinomas of the Vaterian system are rare and presumably arise from preexisting adenomas (adenoma-carcinoma-sequence).
  • We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater.
  • Although the expression of the cell adhesion proteins did not differ between the carcinoma subtypes, marked differences between normal mucosa, adenoma and carcinoma samples were observed.
  • All marker proteins were expressed in less than 7% of normal mucosa samples (S100A4 in only 1% of cases) and showed an increasing expression from adenoma to invasive carcinoma.
  • [MeSH-major] Adenoma / chemistry. Ampulla of Vater / chemistry. Antigens, CD24 / analysis. Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma / chemistry. Common Bile Duct Neoplasms / chemistry. S100 Proteins / analysis

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  • (PMID = 19043399.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD24; 0 / Biomarkers, Tumor; 0 / CD24 protein, human; 0 / CDH3 protein, human; 0 / Cadherins; 0 / S100 Proteins; 142662-27-9 / S100A4 protein, human
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62. Baumhoer D, Zlobec I, Tornillo L, Dietmaier W, Wuensch PH, Hartmann A, Sessa F, Ruemmele P, Terracciano LM: Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater. Virchows Arch; 2008 Dec;453(6):579-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Carcinomas of the ampulla of Vater are rare and assumed to generally arise from preexisting adenomas (adenoma-carcinoma sequence).
  • We therefore performed immunohistochemistry using a panel of established marker proteins (CK7, CK20, p21, p27, ESA, bax, and ephrin-B2) on 175 carcinoma, 111 adenoma, and 152 normal mucosa specimens of the ampulla of Vater and identified distinct immunoprofiles for every carcinoma subtype.
  • [MeSH-major] Adenoma / metabolism. Ampulla of Vater / metabolism. Common Bile Duct Neoplasms / metabolism. Cyclin D1 / metabolism. Keratin-7 / metabolism. Receptor, ErbB-2 / metabolism. bcl-2-Associated X Protein / metabolism

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  • (PMID = 18936968.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CCND1 protein, human; 0 / Ephrin-B2; 0 / Keratin-20; 0 / Keratin-7; 0 / MYC protein, human; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-myc; 0 / bcl-2-Associated X Protein; 0 / p27 antigen; 136601-57-5 / Cyclin D1; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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63. Chahal P, Prasad GA, Sanderson SO, Gostout CJ, Levy MJ, Baron TH: Endoscopic resection of nonadenomatous ampullary neoplasms. J Clin Gastroenterol; 2007 Aug;41(7):661-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The safety and effectiveness of endoscopic management of ampullary adenomas is well known.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Endoscopy, Digestive System

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  • (PMID = 17667049.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Cione GP, Cerbone D, Di Benedetto A, Podio P, Cimmino G, Parmeggiani D, Peltrini A, Lombardi V, Perrotta M: [Intrahepatic biliary cystadenoma: case report]. Suppl Tumori; 2005 May-Jun;4(3):S48-50
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Cistoadenoma biliare intraepatico: case report.
  • According to the OMS classification of the epithelial benign neoplasm of the liver, the adenomas represent the most important group.
  • The biliar cistoadenoma (BCA) represents a not frequent neoplasm of the liver that has origin on the inside of the liver, and less frequently from the extrahepatic biliar system.
  • [MeSH-major] Bile Duct Neoplasms. Bile Ducts, Intrahepatic. Cystadenoma

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  • (PMID = 16437897.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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65. Ogawa H, Itoh S, Ikeda M, Suzuki K, Naganawa S: Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT. Radiology; 2008 Sep;248(3):876-86
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two radiologists blinded to the pathologic assessment of malignancy or parenchymal invasion of IPMN retrospectively evaluated CT images of 61 consecutive surgically resected tumors (26 adenomas, 15 noninvasive carcinomas, and 20 invasive carcinomas) in patients who underwent multiphase contrast material-enhanced CT with 0.5- or 1-mm collimation.
  • RESULTS: The following findings showed significant differences among the three groups: maximum diameter of the main pancreatic duct (MPD), size (length of major axis) of the largest mural nodule in the MPD or in any associated cystic lesion, abnormal attenuating area in the surrounding parenchyma, calcification in the lesion, protrusion of the MPD into the ampulla of Vater, and bile duct dilatation.
  • CONCLUSION: Multisection CT is useful for distinguishing among adenoma, noninvasive carcinoma, and invasive carcinoma in patients with IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / radiography. Adenoma / radiography. Pancreatic Neoplasms / radiography. Papilloma, Intraductal / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] RSNA, 2008
  • (PMID = 18632526.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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66. Albores-Saavedra J, Schwartz AM, Batich K, Henson DE: Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program. J Surg Oncol; 2009 Dec 1;100(7):598-605

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In both African Americans and Caucasians, the disease is more common in men.
  • Papillary carcinomas had a more favorable survival than other types; carcinomas arising in adenomas had a more favorable survival than adenocarcinomas not associated with adenomas.
  • CONCLUSIONS: Prognostic factors include histologic type, grade, stage, and coexisting adenomas.
  • Although certain histologic types exhibit morphologic differences, their pathogenesis appears to be similar.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma / mortality. Common Bile Duct Neoplasms / mortality

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  • (PMID = 19697352.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Celli N, Gaiani S, Piscaglia F, Zironi G, Camaggi V, Leoni S, Righini R, Bolondi L: Characterization of liver lesions by real-time contrast-enhanced ultrasonography. Eur J Gastroenterol Hepatol; 2007 Jan;19(1):3-14
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The aim of this study was to identify the most common patterns of various common liver lesions at real-time contrast-enhanced ultrasonography with second-generation contrast agents and their role in the differentiation of malignant from benign lesions.
  • PATIENTS AND METHODS: The enhancement pattern in the arterial phase and its modifications in subsequent portal and sinusoidal phases were separately evaluated in (i) 171 liver lesions detected at conventional ultrasonography in 125 noncirrhotic patients (87 metastases, six cholangiocellular carcinoma, 38 focal nodular hyperplasia, 30 hemangiomas, seven focal fatty sparing/changes, two hepatocellular adenomas and one hepatocellular carcinoma) and (ii) 75 lesions detected in 67 cirrhotic patients (66 hepatocellular carcinoma and nine dysplastic nodules).
  • CONCLUSION: Real-time contrast-enhanced ultrasonography provides sensitive and specific criteria for the differential diagnosis between benign and malignant liver lesions, and in most cases it may replace more expensive and invasive imaging techniques.
  • [MeSH-minor] Adenoma, Liver Cell / ultrasonography. Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / ultrasonography. Cholangiocarcinoma / ultrasonography. Diagnosis, Differential. Female. Focal Nodular Hyperplasia / ultrasonography. Hemangioma / ultrasonography. Humans. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Male. Microbubbles. Middle Aged. Ultrasonography, Doppler / methods

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  • (PMID = 17206071.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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68. Di Giorgio A, Alfieri S, Rotondi F, Prete F, Di Miceli D, Ridolfini MP, Rosa F, Covino M, Doglietto GB: Pancreatoduodenectomy for tumors of Vater's ampulla: report on 94 consecutive patients. World J Surg; 2005 Apr;29(4):513-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A total of 94 consecutive patients with ampullary carcinoma or adenoma with severe dysplasia were managed from 1981 to 2002.
  • Pancreatoduodenectomy is the treatment of choice for ampullary carcinoma and adenomas with high-grade dysplasia, with a good chance of long-term survival.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 15776300.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Winter JM, Cameron JL, Olino K, Herman JM, de Jong MC, Hruban RH, Wolfgang CL, Eckhauser F, Edil BH, Choti MA, Schulick RD, Pawlik TM: Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis. J Gastrointest Surg; 2010 Feb;14(2):379-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Between 1970 and 2007, 450 patients who underwent surgical resection of ampullary adenoma or adenocarcinoma were identified from a prospective, single-institution database.
  • Final diagnosis was invasive adenocarcinoma (77.1%) or adenoma (22.9%).
  • Median tumor size was similar for adenomas associated with an adenocarcinoma (2.5 cm) versus adenomas without invasive cancer (2.9 cm; P=0.71).
  • Metastatic disease to regional lymph nodes was present in 54.5% patients with adenocarcinoma.
  • CONCLUSION: When surgery is indicated, radical resection is required for early invasive adenocarcinoma of the ampulla of Vater, as lymph node metastases are present in nearly 30% of patients with T1 disease.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery

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  • (PMID = 19911239.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 1KL2RR025006-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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70. Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW: Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg; 2008 Aug;207(2):210-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: There were 33 benign (32 adenomas and 1 paraganglioma) and 124 malignant (118 adenocarcinomas and 6 neuroendocrine) tumors.
  • The current concept of ampullary adenocarcinoma as a unique entity, distinct from duodenal and pancreatic adenocarcinoma, might be wrong.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Follow-Up Studies. Humans. Jaundice, Obstructive / mortality. Jaundice, Obstructive / pathology. Jaundice, Obstructive / surgery. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Risk Factors

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  • (PMID = 18656049.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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71. Nassar H, Albores-Saavedra J, Klimstra DS: High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol; 2005 May;29(5):588-94
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  • Overall, 64% of patients with ampullary HGNEC died of disease (mean follow-up, 14.5 months).
  • Four patients had no evidence of disease after resection (mean, 20 months).
  • Half of the tumors were associated with adenomas of the adjacent mucosa, 2 with high-grade dysplasia.
  • The association with adenoma and or conventional adenocarcinoma components may suggest a common pathway in the initial carcinogenesis of these two types of tumors.
  • Loss of Rb expression, a characteristic finding in pulmonary SCCs, is present in almost half of ampullary HGNECs.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 15832081.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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72. Wang L, Camus AC, Dong W, Thornton C, Willett KL: Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis. Aquat Toxicol; 2010 Sep 15;99(4):439-47
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  • Histopathologic findings included foci of cellular alteration and neoplasms, including hepatocellular adenoma, hepatocellular carcinoma and cholangioma.
  • In contrast, CYP1C1 was only detectable and highly expressed in proliferated bile duct epithelial cells.

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
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  • (PMID = 20621368.001).
  • [ISSN] 1879-1514
  • [Journal-full-title] Aquatic toxicology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Aquat. Toxicol.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / ES012710-05S1; United States / NIEHS NIH HHS / ES / R01 ES012710; United States / NIEHS NIH HHS / ES / R01 ES012710-05S1; United States / NIEHS NIH HHS / ES / R01ES012710
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 3417WMA06D / Benzo(a)pyrene; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; YOW8V9698H / Dimethyl Sulfoxide
  • [Other-IDs] NLM/ NIHMS222714; NLM/ PMC2924930
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73. Xu HX, Chen LD: Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings. J Clin Ultrasound; 2008 Jan;36(1):39-41
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  • [Title] Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings.
  • We report a case of villous adenoma in the extrahepatic bile duct that was successfully diagnosed with contrast-enhanced sonography (CEUS) before surgical resection.
  • On baseline sonography, the mass appeared as a homogeneously isoechoic mass filling the bile duct from the confluence of the right and left hepatic ducts to the distal common bile duct.
  • Surgical resection was performed, and pathologic examination confirmed a villous adenoma of the bile duct epithelium with mild dysplasia.
  • [MeSH-major] Adenoma, Villous / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Extrahepatic / ultrasonography

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17565756.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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74. Bucher P, Chassot G, Durmishi Y, Ris F, Morel P: Long-term results of surgical treatment of Vater's ampulla neoplasms. Hepatogastroenterology; 2007 Jun;54(76):1239-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Among the ampullary neoplasms, 10 were adenomas (median age 71) and 45 adenocarcinomas (median age 69).
  • Of the adenomas 60% were treated surgically with excellent long-term results.
  • After pancreatoduodenectomy, the lymph node status influenced survival, while disease-free survival at 5 years was 85% for NO and 27% for N1 (p < 0.001).
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 17629078.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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75. National Toxicology Program: NTP carcinogenesis studies of 2,2-bis(bromomethyl)-1,3-propanediol, nitromethane, and 1,2,3-trichloropropane (cas nos. 3296-90-0, 75-52-5, and 96-18-4) in guppies (Poecilia reticulata) and medaka (Oryzias latipes) (Waterborne Studies). Natl Toxicol Program Tech Rep Ser; 2005 Oct;(528):1-190
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The use of small fish species in carcinogenicity testing offered potential advantages as a bioassay test system, including significant savings in cost and time over rodent studies.
  • At 9 months, hepatocellular adenomas occurred in one 24 mg/L male and in one 150 mg/L male.
  • In the core study, the incidence of hepatocellular adenoma or carcinoma (combined) in 150 mg/L males was greater than that in the controls; multiple adenomas occurred in two 150 mg/L males and in one 150 mg/L female.
  • Cholangioma occurred in a small number of exposed males and females.
  • In the stop-exposure study, incidences of hepatocellular adenoma (including multiple) and of hepatocellular carcinoma were greater in 150 mg/L males than in controls.
  • One cholangioma and one cholangiocarcinoma occurred in the 150 mg/L female group.
  • In the core study, the incidence of hepatocellular adenoma or carcinoma (combined) was increased in 150 mg/L males.
  • One cholangioma occurred in a 150 mg/L female, and one occurred in a control female.
  • In the stop-exposure study, incidences of hepatocellular adenoma or carcinoma (combined) were marginally increased in the 150 mg/L group of males and in the 60 and 150 mg/L groups of females as compared with controls.
  • The biological significance of this finding is unknown.
  • Hepatocellular adenomas occurred in two 20 mg/L males and in one 40 mg/L female.
  • In the core study, one cholangioma occurred in a 20 mg/L male, and cholangiocarcinomas were seen in a few exposed males, but none occurred in control males.
  • At 9 months, multiple hepatocellular adenomas occurred in one 4.5 mg/L male, and one hepatocellular adenoma occurred in a control male.
  • In the core study, increased incidences of cholangiocellular (bile duct) and hepatocellular neoplasms occurred in exposed groups of males and females.
  • Cholangioma and cholangiocarcinoma were seen in several exposed males and females.
  • In the stop-exposure study, increased incidences of hepatocellular neoplasms occurred in 18.0 mg/L males and increased incidences of cholangiocellular (bile duct) neoplasms occurred in 18.0 mg/L females. (ABSTRACT TRUNCATED)

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  • (PMID = 16362062.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Nitroparaffins; 0 / Propylene Glycols; 0 / Water Pollutants, Chemical; 3296-90-0 / 2,2-bis(bromomethyl)-1,3-propanediol; 3MJ7QCK0Z0 / 1,2,3-trichloropropane; OP0UW79H66 / Methane; RU5WG8C3F4 / nitromethane; T75W9911L6 / Propane
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76. Gupta R, Mortelé KJ, Tatli S, Girshman J, Glickman JN, Levy AD, Erturk SM, Heffess CS, Banks PA, Silverman SG: Pancreatic intraductal papillary mucinous neoplasms: role of CT in predicting pathologic subtypes. AJR Am J Roentgenol; 2008 Nov;191(5):1458-64
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  • MATERIALS AND METHODS: Three radiologists, blinded to the pathologic IPMN subtype, retrospectively and independently reviewed the preoperative CT scans of 38 patients with surgically resected pancreatic IPMN: 11 intraductal papillary mucinous adenomas, 11 intraductal papillary mucinous carcinomas, and 16 intraductal papillary mucinous carcinomas with invasion.
  • RESULTS: Predominant main pancreatic duct (MPD) involvement (p = 0.04) and a wide (> 1 cm) connection of a side-branch lesion with the MPD (p = 0.03) correlated with intraductal papillary mucinous carcinoma with invasion.
  • Tumor size, MPD diameter, number of tumors per patient, number of pseudoseptations per tumor, common bile duct dilatation, enlarged lymph nodes, intraductal calcifications, papillary bulging, and presence and size of a solid mass yielded no statistically significant relationship with pathologic subtype.
  • Predominant MPD involvement and a wide connection of a side-branch lesion with the MPD are the only CT findings that can be used to predict the pathologic subtype of pancreatic IPMN.

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  • [ErratumIn] AJR Am J Roentgenol. 2008 Dec;191(6):1876
  • (PMID = 18941085.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Fischer HP, Zhou H: [Nodular lesions of liver parenchyma caused by pathological vascularisation/perfusion]. Pathologe; 2006 Jul;27(4):273-83
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  • In contrast to hepatocellular adenoma, they show a more or less nodular architecture with fibrous septa and ductular structures.
  • NRH and cases of MRN without cirrhosis can indicate an extrahepatic/systemic disease causing altered liver perfusion.
  • Telangiectatic FNH might resemble classic hepatocellular adenoma.
  • Neoductular transformation of hypoperfused liver parenchyma might imitate cholangioma or cholangiocarcinoma.

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  • (PMID = 16773311.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 45
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78. National Toxicology Program: NTP toxicology and carcinogenesis studies of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in female Harlan Sprague-Dawley rats (Gavage Studies). Natl Toxicol Program Tech Rep Ser; 2006 Jan;(520):4-246

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since human exposure to DLCs always occurs as a complex mixture, the Toxic Equivalency Factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD that is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) was produced commercially before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.
  • PCB 126 was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs.
  • At 2 years, there were significant treatment-related increases in the incidences of cholangiocarcinoma and hepatocellular adenoma.
  • Three hepatocholangiomas were seen in the 1,000 ng/kg core study group and a single incidence of cholangioma each occurred in the 550 and 1,000 ng/kg core study groups.
  • At 2 years, a significant dose-related increase in hepatic toxicity was observed and was characterized by increased incidences of numerous lesions including hepatocyte hypertrophy, multinucleated hepatocytes, diffuse fatty change, bile duct hyperplasia, bile duct cyst, oval cell hyperplasia, necrosis, pigmentation, inflammation, nodular hyperplasia, portal fibrosis, cholangiofibrosis, and toxic hepatopathy.
  • At 2 years, adenomas and/or carcinomas were present in the adrenal cortex of most core study groups and in the 1,000 ng/kg stop-exposure group.

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  • (PMID = 16628245.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Thyroid Hormones; DFC2HB4I0K / Polychlorinated Biphenyls; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl
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79. Kim SJ, Lee HW, Kim DC, Rha SH, Hong SH, Jeong JS: Significance of GLUT1 expression in adenocarcinoma and adenoma of the ampulla of Vater. Pathol Int; 2008 Apr;58(4):233-8
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  • [Title] Significance of GLUT1 expression in adenocarcinoma and adenoma of the ampulla of Vater.
  • Twenty-one (58.3%) of 36 adenocarcinomas and three (17.6%) of 17 adenomas had GLUT1 immunoreactivity.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Ampulla of Vater / metabolism. Common Bile Duct Neoplasms / metabolism. Glucose Transporter Type 1 / metabolism

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  • (PMID = 18324916.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glucose Transporter Type 1; 0 / SLC2A1 protein, human
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80. Tátrai P: [Selective deposition of agrin in the microvasculature of hepatocellular carcinoma: aspects in pathogenesis and differential diagnosis]. Magy Onkol; 2008 Dec;52(4):379-83
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  • This novel finding prompted us to investigate the role of agrin in the pathogenesis and differential diagnosis of HCC.
  • Our subsequent experiments were carried out on specimens from 131 patients with chronic liver disease and 18 individuals with healthy liver, from 4 rats subjected to cirrhosis/HCC induction and 1 untreated control rat, as well as from cultured cells.
  • By double immunofluorescent studies, agrin was localized to the muscular layer of blood vessel walls, the BM of bile ducts and ductular reaction, the microvessel walls of HCC, and occasionally the BM of hepatocellular tumor cells.
  • Colocalization, gene expression, and mRNA in situ hybridization experiments suggested that the sources of agrin include vascular smooth muscle cells, epithelial cells of bile ducts and ductules, activated mesenchymal cells in the stroma of hepatocellular tumors, and occasionally tumor hepatocytes.
  • Agrin in the BMs of bile ducts and blood vessels is thought to play an important role in the survival of bile duct epithelium and vascular endothelium, respectively.
  • As opposed to HCC neovessels that were consistently found agrin-positive, normal and cirrhotic sinusoids were always devoid of agrin, raising the possibility that agrin IHC might be useful in the differential diagnosis of benign versus malignant hepatocellular lesions.
  • Agrin IHC was performed on 68 benign lesions (8 large regenerative nodules, 23 low-grade and 7 high-grade dysplastic nodules, 30 liver adenomas) and 29 malignant lesions (8 small HCC, 21 HCC), and was evaluated semi-quantitatively.
  • Based on the results of IHC for agrin as well as CD34, a decision algorithm was devised that differentiated benign and malignant parenchymal lesions with a sensitivity of 93.1% and a specificity of 92.6%.
  • Hence, we propose that agrin IHC might help distinguish between malignant hepatocellular lesions and their benign mimickers.

  • MedlinePlus Health Information. consumer health - Cirrhosis.
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  • (PMID = 19068466.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Agrin; 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / Heparan Sulfate Proteoglycans; 0 / RNA, Messenger
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81. Xie CM, Zheng L, Mo YX, Li L, Ruan CM, Lu YC, Wu PH: [Helical double-phase CT scan imaging features of hepatocellular carcinoma and pathology of false-positive lesions]. Ai Zheng; 2007 Jan;26(1):68-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: CT scan showed 56 lesions in the 52 patients: 51 were cancer lesions, including 49 HCC lesions and 2 mixed lesions of HCC and cholangioma, 5 were false-positive lesions.
  • The pathologic diagnoses of the 5 false-positive lesions were hepatic cirrhosis with hepatocellular nodular hyperplasia, regenerative nodule, hepatic cirrhosis, bile duct calculus companied with inflammatory reaction, and fibrosis hyperplasia.

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  • (PMID = 17222371.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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82. Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser; 2006 Feb;(533):1-264
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Benzophenone is used as a photoinitiator, a fragrance enhancer, an ultraviolet curing agent, and occasionally as a flavor ingredient; it is also used in the manufacture of insecticides, agricultural chemicals, and hypnotics, antihistamines, and other pharmaceuticals; and it is used as an additive in plastics, coatings, and adhesive formulations.
  • There was a positive trend in the incidences of renal tubule adenoma in males, and the incidences in 625 and 1,250 ppm males exceeded the historical control range for all routes; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Due to these findings, additional kidney sections were evaluated; results indicated additional renal tubule adenomas in all groups of males and renal tubule hyperplasia in all groups of males and females.
  • Liver lesions included significantly increased incidences of hepatocytic centrilobular hypertrophy in all exposed groups of males and females, cystic degeneration in 625 and 1,250 ppm males, and bile duct hyperplasia in all exposed groups of females.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups, and these incidences exceeded the historical control range.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • CONCLUSIONS: Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma; mononuclear cell leukemia in male F344/N rats may have been related to benzophenone exposure.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F1 mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F1 mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F1 mice may have been related to benzophenone exposure.

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  • (PMID = 16741556.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
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83. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage Studies). Natl Toxicol Program Tech Rep Ser; 2006 Apr;(521):4-232
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since human exposure to DLCs always involves a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • TCDD (dioxin) was selected for study by the National Toxicology Program as a part of the dioxin TEF evaluation to assess the cancer risk posed by complex mixtures of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCBs.
  • At 2 years, there was a significant increase in toxic hepatopathy characterized by increased incidences of numerous nonneoplastic liver lesions including hepatocyte hypertrophy, multinucleated hepatocytes, altered hepatocellular foci, inflammation, pigmentation, diffuse fatty change, necrosis, portal fibrosis, oval cell hyperplasia, bile duct hyperplasia, bile duct cysts, cholangiofibrosis, and nodular hyperplasia At 2 years, the incidence of hepatocellular adenoma was significantly increased in the 100 ng/kg core study group.
  • Two cholangiocarcinomas and two hepatocellular adenomas were seen in the 100 ng/kg stop-exposure group.
  • Two hepatocholangiomas were seen in the 100 ng/kg core study group, and one cholangioma was seen in the 100 ng/kg stop-exposure group.
  • At 2 years, one acinar adenoma and two acinar cell carcinomas of the pancreas were seen in the 100 ng/kg core study group; one acinar carcinoma was seen in the 100 ng/kg stop-exposure group.
  • The incidences of acinar cell adenoma or carcinoma (combined) exceeded the historical vehicle control range.

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  • (PMID = 16835633.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; DO80M48B6O / Tetrachlorodibenzodioxin
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84. Kozarek RA: The society for gastrointestinal intervention. Are we, as an organization of disparate disciplines, cooperative or competitive? Gut Liver; 2010 Sep;4 Suppl 1:S1-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As such, Interventional Radiology is housed in the Radiology Department, Laparoscopic Surgery (and potentially NOTES), as a component of the General Surgery Division, and Therapeutic Endoscopy usually resides within a gastroenterology structural framework.
  • As a group, the amount of practice devoted to GI disorders is variable (for instance, minimally invasive surgeons may approach the adrenal glands or lung lesions in some institutions and interventional radiologists often sample tissue in multiple areas outside the GI tract, and by virtue of access to the vascular tree, can stent, embolize, or TPA almost any area of the body), as well as inherent differences in our individual abilities to access organs.
  • The same has proven true for many years for colorectal polyps, superficial gastric cancers, and ampullary adenomas that had historically all been treated with major surgical resections.
  • By way of contrast, acute cholecystectomy tubes in high surgical risk patients have usually been the domain of the radiologist, although I described transcystic duct gallbladder decompression endoscopically 2½ decades ago.
  • There are 2 prospective randomized trials (level 1 evidence) that suggest that patients with proximal strictures (Bismuth II-IV) in conjunction with bile duct and gallbladder cancer, respectively, may be more successfully stented percutaneously and certainly it is easier to deliver brachytherapy or PDT under protocol to these patients who have indwelling external drains.
  • If your university or clinic will not allow blurring of training barriers to put therapeutic endoscopists, minimally invasive surgeons, and interventional radiologists together as a department or institute, you can nevertheless work together as a team in the best interest of your patients.

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  • (PMID = 21103287.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2989558
  • [Keywords] NOTNLM ; Interventional radiology / Minimally invasive surgery / Therapeutic endoscopy
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85. National Toxicology Program: Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Nov;(559):1-174

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Since human exposure to DLCs always occurs as a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • At the 53-week interim evaluation, three 4,600 g/kg rats had liver cholangiocarcinoma and one had hepatocellular adenoma.
  • At 2 years, there were significant treatment-related increases in the incidences of cholangiocarcinoma and hepatocellular adenoma.
  • Four incidences of hepatocholangioma occurred in the 4,600 g/kg core study group.
  • At 2 years, a significant dose-related increase in hepatic toxicity was observed and was characterized by increased incidences of numerous lesions including hepatocyte hypertrophy, inflammation, oval cell hyperplasia, pigmentation, multinucleated hepatocyte, eosinophilic and mixed cell foci, diffuse fatty change, toxic hepatopathy, nodular hyperplasia, necrosis, bile duct hyperplasia and cyst, and cholangiofibrosis.
  • At 2 years, there were marginally increased incidences of exocrine pancreatic adenoma or carcinoma in the 460, 1,000, and 4,600 g/kg core study groups.
  • CONCLUSIONS: Under the conditions of this 2-year gavage study, there was clear evidence of carcinogenic activity of PCB 118 in female Harlan Sprague-Dawley rats based on increased incidences of neoplasms of the liver (cholangiocarcinoma, hepatocholangioma, and hepatocellular adenoma) and cystic keratinizing epithelioma of the lung.

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  • (PMID = 21383778.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 31508-00-6 / 2,3',4,4',5-pentachlorobiphenyl; DFC2HB4I0K / Polychlorinated Biphenyls; DO80M48B6O / Tetrachlorodibenzodioxin
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86. Meneghetti AT, Safadi B, Stewart L, Way LW: Local resection of ampullary tumors. J Gastrointest Surg; 2005 Dec;9(9):1300-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There is no consensus on the appropriateness of local resection for ampullary tumors, because malignant recurrence of what were thought to be benign tumors has been reported.
  • Preoperative biopsies (obtained in all patients) showed 18 adenomas, four adenomas with dysplasia, five adenomas with atypia, one adenoma with dysplasia and focal adenocarcinoma, and two tumors seen on endoscopy, whose biopsies showed only duodenal mucosa.
  • The final pathologic diagnosis was 23 villous adenomas, six adenocarcinomas, and one paraganglioma.
  • Among the 23 adenomas, three (13%) recurred (all as adenomas) at a mean of 3.2 years; in only one of these cases was the margin positive at the time of resection.
  • Ampullary adenomas can be resected locally with good results, but the recurrence rate was 13%, so endoscopic surveillance is indicated postoperatively.
  • No adenomas recurred as carcinomas, suggesting that local resection is appropriate for these tumors in the absence of dysplasia or atypia on preoperative biopsies.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged

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  • (PMID = 16332486.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. National Toxicology Program: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 Aug;(530):1-258
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies).
  • Since human exposure to DLCs always occurs as a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • 2-YEAR STUDY: The 2-year study of a binary mixture of PCB 126 and PCB 153 was designed to assess the carcinogenicity of a constant ratio mixture of PCB 126 and PCB 153.
  • At the end of the 2-year study, there were significantly increased incidences and severities of toxic hepatopathy characterized by hepatocyte hypertrophy, multinucleated hepatocytes, pigmentation, diffuse and focal fatty change, eosinophilic focus, nodular hyperplasia, cholangiofibrosis, oval cell hyperplasia, bile duct cysts, bile duct hyperplasia, necrosis, and portal fibrosis.
  • Significantly increased incidences of hepatocellular adenoma, cholangiocarcinoma, and hepatocholangioma were observed in the study.

  • Hazardous Substances Data Bank. 2,2',4,4',5,5'-HEXACHLOROBIPHENYL .
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  • (PMID = 17160104.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; DFC2HB4I0K / Polychlorinated Biphenyls; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl; ZRU0C9E32O / 2,4,5,2',4',5'-hexachlorobiphenyl
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88. Nagano K, Sasaki T, Umeda Y, Nishizawa T, Ikawa N, Ohbayashi H, Arito H, Yamamoto S, Fukushima S: Inhalation carcinogenicity and chronic toxicity of carbon tetrachloride in rats and mice. Inhal Toxicol; 2007 Oct;19(13):1089-103
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Incidences of hepatocellular adenomas and carcinomas in rats and mice of both sexes and of adrenal pheochromocytomas in mice of both sexes were significantly increased dose-dependently.
  • Hepatocellular carcinomas were induced in mice of both sexes at 25 and 125 ppm, and hepatocellular adenomas occurred in females at 5 ppm without any degenerative or necrotic change in hepatocytes.
  • The chronic hepatotoxicity was characterized by cirrhosis, fibrosis, and fatty change in rats, and ceroid deposition, bile-duct proliferation, and hydropic change in mice.

  • Hazardous Substances Data Bank. CARBON TETRACHLORIDE .
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  • (PMID = 17957549.001).
  • [ISSN] 1091-7691
  • [Journal-full-title] Inhalation toxicology
  • [ISO-abbreviation] Inhal Toxicol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] CL2T97X0V0 / Carbon Tetrachloride
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89. National Toxicology Program: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 Nov;(531):1-218

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies).
  • Since human exposure to DLCs always occurs as a complex mixture, the toxic equivalency factor (TEF) methodology has been developed as a mathematical tool to assess the health risk posed by complex mixtures of these compounds.
  • The TEF methodology is a relative potency scheme that ranks the dioxin-like activity of a compound relative to TCDD, which is the most potent congener.
  • This allows for the estimation of the potential dioxin-like activity of a mixture of chemicals, based on a common mechanism of action involving an initial binding of DLCs to the AhR.
  • Therefore, this study was reclassified as a mixture study of PCB 126 and PCB 118.
  • At the end of the 2-year study in all dosed groups, there were significantly increased incidences and severity of toxic hepatopathy characterized by hepatocyte hypertrophy, multinucleated hepatocytes, pigmentation, toxic hepatopathy, diffuse fatty change, nodular hyperplasia, centrilobular fibrosis, cholangiofibrosis, oval cell hyperplasia, bile duct cyst, bile duct hyperplasia, and portal fibrosis.
  • The incidences of hepatocellular adenoma were also significantly increased in the 216 and 360 ng TEQ/kg core study groups.
  • In addition, single occurrences of hepatocholangioma, cholangioma, or hepatocellular carcinoma were observed in some dosed groups administered 72 ng TEQ/kg or greater.

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  • (PMID = 17342196.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thyroid Hormones; 31508-00-6 / 2,3',4,4',5-pentachlorobiphenyl; DFC2HB4I0K / Polychlorinated Biphenyls; TSH69IA9XF / 3,4,5,3',4'-pentachlorobiphenyl
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90. Yamao T, Isomoto H, Yamaguchi N, Irie J, Ito Y, Nakashima Y, Shikuwa S, Mizuta Y, Kohno S, Imamura S, Yamakawa M, Fujita F, Hayashi T: Magnified endoscopic observation using narrow-band imaging of periampullary adenoma in a patient with familial adenomatous polyposis. Med Sci Monit; 2009 Dec;15(12):CS169-73
Genetic Alliance. consumer health - Familial Polyposis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnified endoscopic observation using narrow-band imaging of periampullary adenoma in a patient with familial adenomatous polyposis.
  • BACKGROUND: Adenoma of the major papilla carries a relatively high risk of malignant transformation to carcinoma, the leading cause of death in patients with familiar adenomatous polyposis (FAP) after colectomy.
  • Histopathological examination of the removed specimen showed tubular adenoma without malignant foci.
  • CONCLUSIONS: Thus, endoscopic surveillance and removal of ampullary adenomas appear to be justified.
  • [MeSH-major] Adenoma / diagnosis. Adenomatous Polyposis Coli / diagnosis. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Duodenoscopy / methods

  • Genetic Alliance. consumer health - Familial Adenomatous Polyposis (FAP).
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  • (PMID = 19946237.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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91. Jung MK, Cho CM, Park SY, Jeon SW, Tak WY, Kweon YO, Kim SK, Choi YH: Endoscopic resection of ampullary neoplasms: a single-center experience. Surg Endosc; 2009 Nov;23(11):2568-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A benign adenoma has the potential for malignant transformation.
  • Currently, endoscopic papillectomy with curative intent is increasingly performed for benign papillary tumors.
  • Endoscopic resection was performed in a radical fashion analogous to polypectomy for colon adenomas.
  • CONCLUSIONS: The findings showed that an endoscopic papillectomy was safe and effective for benign-appearing adenomas with negative biopsy results for a malignancy.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Ampulla of Vater / surgery. Cholangiopancreatography, Endoscopic Retrograde / methods. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery

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  • (PMID = 19360365.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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92. Tátrai P, Somorácz A, Batmunkh E, Schirmacher P, Kiss A, Schaff Z, Nagy P, Kovalszky I: Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions. Am J Surg Pathol; 2009 Jun;33(6):874-85
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Agrin and CD34 immunohistochemistry for the discrimination of benign versus malignant hepatocellular lesions.
  • Agrin is a recently identified proteoglycan component of vascular and bile duct basement membranes in the liver.
  • We focused on the differential diagnostic problems often presented by hepatocellular adenomas (HCAs) and dysplastic nodules.
  • The majority of benign lesions were clearly agrin-negative, whereas the strength and extent of agrin IHC faithfully reflected dysplasia in "atypical" HCAs and in high-grade dysplastic nodules.
  • In conclusion, as agrin is highly selective for tumor blood vessels, IHC for agrin facilitates the discrimination of benign and malignant hepatocellular lesions.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Agrin / biosynthesis. Antigens, CD34 / biosynthesis. Carcinoma, Hepatocellular / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 19194276.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Agrin; 0 / Antigens, CD34; 0 / Biomarkers, Tumor
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93. Arena V, Arena E, Stigliano E, Capelli A: Bile duct adenoma with oncocytic features. Histopathology; 2006 Sep;49(3):318-20
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bile duct adenoma with oncocytic features.
  • [MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Oxyphil Cells / pathology

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  • (PMID = 16918984.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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94. Standards of Practice Committee, Adler DG, Qureshi W, Davila R, Gan SI, Lichtenstein D, Rajan E, Shen B, Zuckerman MJ, Fanelli RD, Van Guilder T, Baron TH: The role of endoscopy in ampullary and duodenal adenomas. Gastrointest Endosc; 2006 Dec;64(6):849-54
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of endoscopy in ampullary and duodenal adenomas.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / surgery. Endoscopy, Digestive System / standards
  • [MeSH-minor] Adenoma. Humans. Practice Guidelines as Topic

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  • (PMID = 17140885.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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95. Pandolfi M, Martino M, Gabbrielli A: Endoscopic treatment of ampullary adenomas. JOP; 2008;9(1):1-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic treatment of ampullary adenomas.
  • [MeSH-major] Adenoma / surgery. Adenomatous Polyposis Coli / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Gastrointestinal

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  • (PMID = 18182736.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] Italy
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96. Chacko A, Dutta AK: Endoscopic resection of ampullary adenomas: novel technique to reduce post procedure pancreatitis. J Gastroenterol Hepatol; 2010 Aug;25(8):1338-9
Hazardous Substances Data Bank. TEFLON .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of ampullary adenomas: novel technique to reduce post procedure pancreatitis.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Pancreatitis / prevention & control. Sphincterotomy, Endoscopic. Stents

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  • [CommentOn] J Gastroenterol Hepatol. 2010 Aug;25(8):1381-5 [20659227.001]
  • (PMID = 20659220.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] Australia
  • [Chemical-registry-number] 9002-84-0 / Polytetrafluoroethylene
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97. Otani K, Tohara K, Mihara K, Ueki T, Tanaka M, Sakaguchi S, Matsui T, Yao T, Haraoka S, Iwashita A: [A case of intrahepatic bile duct adenoma]. Nihon Shokakibyo Gakkai Zasshi; 2006 Jan;103(1):37-43
MedlinePlus Health Information. consumer health - Bile Duct Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of intrahepatic bile duct adenoma].
  • [MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic

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  • (PMID = 16444984.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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