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Items 1 to 100 of about 199
1. Farag M, Saklani A, N NN, Masoud A: The Red Rectum (Carpet villous adenoma of the rectum). J Surg Case Rep; 2010;2010(10):10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Red Rectum (Carpet villous adenoma of the rectum).
  • Carpeted villous adenomas of rectum may be extensive and not suitable for transanal excision or Endoscopic mucosal resection.

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  • [Copyright] © JSCR.
  • (PMID = 24945847.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649181
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2. Shih CM, Wu SC, Lee CC, Pan CC: Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis. J Chin Med Assoc; 2007 Jan;70(1):33-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis.
  • Villous adenoma is most frequently found in the colon and rectum, seldom in the urinary tract and even more rarely in the ureter or pelvis.
  • The ureteral tumor proved to be villous adenoma by pathologic examination.
  • It should be noted that ureteral villous adenoma may be related to previous enteric-type metaplastic mucosa or ureteritis glandularis, demonstrates profuse production of mucus, and may eventually undergo malignant transformation.
  • [MeSH-major] Adenoma, Villous / complications. Hydronephrosis / etiology. Ureteral Neoplasms / complications

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  • (PMID = 17276931.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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3. Sun JH, Chao M, Zhang SZ, Zhang GQ, Li B, Wu JJ: Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater. World J Gastroenterol; 2008 Aug 7;14(29):4709-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater.
  • The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma.
  • We herein describe an unusual case of a small cell neuroendocrine carcinoma associated with a villous adenoma in the ampulla of Vater with emphasis on computed tomography (CT) and histopathological findings.
  • [MeSH-major] Adenoma, Villous / complications. Ampulla of Vater. Carcinoma, Neuroendocrine / complications. Common Bile Duct Neoplasms / complications

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  • (PMID = 18698690.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738800
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4. Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr: Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal. World J Gastroenterol; 2009 Jul 28;15(28):3560-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal.
  • In particular, adenomas and adenocarcinomas are distinctly rare entities in this region.
  • We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.
  • Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma.
  • Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Anal Canal / pathology
  • [MeSH-minor] Aged, 80 and over. Cell Transformation, Neoplastic / pathology. Disease Progression. Humans. Male. Treatment Outcome

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  • (PMID = 19630115.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2715986
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5. Brenner BM, Stoler DL, Rodriguez L, Karpenko MJ, Swede H, Petrelli NJ, Anderson GR: Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers. Cancer Genet Cytogenet; 2007 Apr 1;174(1):9-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers.
  • Allelic imbalances in premalignant villous adenomas were compared with those in adjacent microdissected colorectal carcinoma that had arisen directly from the adenomas.
  • Carcinoma-adenoma pairs were examined from 17 patients who underwent resections for colorectal cancer.
  • Loss of heterozygosity for multiple markers was found in 35% of adenomas and 65% of carcinomas; the average fractional allelic loss rate was 2.5 times higher in carcinomas than in adenomas.
  • Of the 17 patients, 4 had MSI for >30% of markers in both adenoma and carcinoma, with no significant differences between the two tissues.
  • Markers with particularly high imbalance rates in adenomas were seen on chromosomes 11, 14, and 15.
  • These findings provide further evidence that genomic instability is an ongoing process during carcinogenesis, with a markedly increased frequency of allelic losses seen in carcinomas, compared with adjacent adenomas.

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  • (PMID = 17350461.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA074127; United States / NCI NIH HHS / CA / R01 CA074127-07; United States / NCI NIH HHS / CA / R01CA74127
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS20123; NLM/ PMC1855249
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6. Krstic M, Alempijevic T, Stimec B, Micev M, Milicevic M, Micic D, Jankovic G: Gallbladder villous adenoma in a patient with acromegaly: a case report. World J Gastroenterol; 2007 Jun 14;13(22):3144-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder villous adenoma in a patient with acromegaly: a case report.
  • Villous adenomas are benign epithelial lesions with malignant potential that can occur in any part of the gastrointestinal tract.
  • An open cholecystectomy was performed and revealed a villous adenoma with several foci of carcinoma in situ.
  • [MeSH-major] Acromegaly. Adenoma, Villous / ultrasonography. Gallbladder Neoplasms / ultrasonography

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  • (PMID = 17589936.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4172627
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7. Zarineh A, Bulakhtina E, Olson PR, Silverman JF: Recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum. Case Rep Med; 2009;2009:361212

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum.
  • Villous adenomas of the urinary tract are an uncommon, well-recognized entity, described in different locations.
  • We present the first case of a recurrent villous adenoma with high-grade dysplasia unassociated with adenocarcinoma, arising from a urethral diverticulum.
  • There were focal areas with stratification to the luminal surface and loss of nuclear polarity and atypical mitoses, interpreted as villous adenoma with high-grade dysplasia.
  • We also present a brief literature review of urothelial villous adenomas.

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  • (PMID = 19718251.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729294
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8. Frickmann H, Jungblut S, Bargon J, Willenbrock K, Störkel S, Hanke P: [Villous adenoma of the renal pelvis and ureter]. Urologe A; 2006 Nov;45(11):1435-7
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  • [Title] [Villous adenoma of the renal pelvis and ureter].
  • [Transliterated title] Villöses Adenom des Nierenbeckens und Ureters.
  • Villous adenomas of the urinary tract are extremely rare tumours belonging to the adenoepithelial metaplasias.
  • We describe the case of an 85-year-old female patient suffering from a villous adenoma of the renal pelvis and ureter.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Kidney Neoplasms / diagnosis. Kidney Pelvis. Neoplasms, Multiple Primary / diagnosis. Ureteral Neoplasms / diagnosis

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  • (PMID = 16900367.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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9. Sierra-Montenegro E, Rocha-Ramírez JL, Villaneuva-Sáenz E, de la Serna-Ortiz I, Fernández-Rivero JM, Soto-Quirino R: [Villous adenoma of the rectum with severe hydroelectric alterations. Report of two cases]. Cir Cir; 2007 Sep-Oct;75(5):377-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Villous adenoma of the rectum with severe hydroelectric alterations. Report of two cases].
  • [Transliterated title] Adenoma velloso de recto con alteración hidroelectrolítica severa. Informe de dos casos.
  • BACKGROUND: Approximately 10% of all colorectal adenomas are constituted by villous adenomas.
  • We report two cases with villous adenoma that presented hydroelectrolytic depletion with clinical and surgical management, exclusively.
  • We also performed a transanal resection of tumor reporting villous adenoma.
  • CONCLUSIONS: Size and location of the villous adenoma are related to the production of mucus secretory diarrhea.
  • In every patient with presence of mucus, persistent diarrhea and occasional rectal bleeding of 1 month, it is necessary to carry out lower endoscopy to rule out the presence of villous adenoma.
  • [MeSH-major] Adenoma, Villous / complications. Rectal Neoplasms / complications. Water-Electrolyte Imbalance / etiology

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  • (PMID = 18158885.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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10. Husillos Alonso A, Subirá Ríos D, Molina Escudero R, Hernández Fernández C: Villous adenoma in augmentation colocystoplasty asociated to infiltrating urotelial cancer in bladder remanent. Arch Esp Urol; 2010 Dec;63(10):876-9
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  • [Title] Villous adenoma in augmentation colocystoplasty asociated to infiltrating urotelial cancer in bladder remanent.
  • OBJECTIVE: To report a new case of villous adenoma developed in augmentation colocystoplasty.
  • RESULTS: We report the case of a 66 year-old man with a villous adenoma and synchronic infiltrating transitional cell carcinoma of the bladder after augmentation colocystoplasty.
  • The latency period until the development of villous adenoma after surgery is long.
  • CONCLUSIONS: Villous adenoma is a benign neoplasm that occurs in the colonic mucosa and shows a high ability to become a malignant colonic cancer.
  • Only two cases of villous adenoma in augmentation colocystoplasty have been reported.
  • [MeSH-major] Adenoma, Villous / etiology. Carcinoma, Transitional Cell / etiology. Neoplasms, Multiple Primary / etiology. Urinary Bladder Neoplasms / etiology. Urinary Reservoirs, Continent / adverse effects

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  • (PMID = 21187572.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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11. Decker CJ: Transanal excision of rectal villous adenomas by laparoscopic methods. J Laparoendosc Adv Surg Tech A; 2005 Feb;15(1):23-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal excision of rectal villous adenomas by laparoscopic methods.
  • Large villous adenomas of the rectum are not uncommon and will be encountered often by general and colorectal surgeons in their practices.
  • The approach to large adenomas can be via the colonoscope either transabdominally or transanally.
  • The method is simple and allows access to lesions up to 15 cm from the anal verge with a low incidence of complications, residual disease, and recurrence.
  • [MeSH-major] Adenoma, Villous / surgery. Laparoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 15772472.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Nguyen AV, Albers CG, Holcombe RF: Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. Int J Mol Med; 2010 Jul;26(1):121-5
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  • [Title] Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles.
  • This study was undertaken to define whether differences in the expression of Wnt pathway components are present between normal colonic mucosa, early (tubular) adenomas and villous adenomas which have a higher malignant potential.
  • Normal mucosa, tubular adenomas and villous adenomas were obtained from twelve patients.
  • Fifteen Wnt pathway-related genes showed differential expression between villous adenomas and normal mucosa and villous and tubular adenomas at a significance level of p<0.01.
  • Genes involved in canonical Wnt (beta-catenin) signaling with increased expression in villous adenomas included wnt1, fz2, csnk2A2, pygo2, pygo1, frat2 and myc, the latter confirmed by qRT-PCR and IHC.
  • Myc protein expression was confined primarily to stromal components of villous adenomas.
  • Genes involved in non-canonical Wnt signaling with increased expression in villous adenomas included rho-u, daam1, damm2, cxxc4 and nlk.
  • Successive increases in the expression of ctnnb1 (beta-catenin) from normal to tubular adenomas to villous adenomas was seen.
  • The Wnt pathway gene expression profile can differentiate between tubular and villous adenomas.
  • These data suggest that Wnt signaling regulation changes during the progression from normal mucosa to tubular adenomas to villous adenomas.
  • Expression of Myc in adenoma stroma suggests a dynamic signaling network within adenomas between mucosal and stromal elements.
  • Inhibition of the Wnt pathway may provide a novel approach for cancer prevention in patients with benign tubular adenomas.
  • [MeSH-major] Adenoma / genetics. Adenoma, Villous / genetics. Colonic Neoplasms / genetics. Gene Expression Profiling. Signal Transduction / genetics

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  • (PMID = 20514431.001).
  • [ISSN] 1791-244X
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA82450
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Wnt Proteins
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13. Xu HX, Chen LD: Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings. J Clin Ultrasound; 2008 Jan;36(1):39-41
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  • [Title] Villous adenoma of extrahepatic bile duct: contrast-enhanced sonography findings.
  • We report a case of villous adenoma in the extrahepatic bile duct that was successfully diagnosed with contrast-enhanced sonography (CEUS) before surgical resection.
  • Surgical resection was performed, and pathologic examination confirmed a villous adenoma of the bile duct epithelium with mild dysplasia.
  • [MeSH-major] Adenoma, Villous / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Extrahepatic / ultrasonography

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc.
  • (PMID = 17565756.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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14. Ratanarapee S, Uiprasertkul M, Pradniwat K, Soontrapa S: Villous adenoma of the urinary bladder: a case report. J Med Assoc Thai; 2010 Nov;93(11):1336-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villous adenoma of the urinary bladder: a case report.
  • Villous adenomas of the urinary tract are rare, in contrast to urothelial neoplasms.
  • The histopathology is identical to that of the much more common villous adenoma of the gastrointestinal tract.
  • The authors reported a case of urinary bladder villous adenoma in a 41-year-old Thai patient who complained of hematuria for one day without any other symptom.
  • Transurethral resection was performed Histologic examination revealed typical features of villous adenoma.
  • The tumor showed identical immunohistochemical profile to colonic villous adenoma.
  • [MeSH-major] Adenoma, Villous / pathology. Urethral Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 21114216.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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15. Suppiah A, Barandiaran J, Morgan R, Perry EP: First case of villous adenoma of the appendix leading to acute appendicitis presenting as strangulated femoral hernia: changes in management owing to concurrent adenoma. Hernia; 2008 Feb;12(1):95-8
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  • [Title] First case of villous adenoma of the appendix leading to acute appendicitis presenting as strangulated femoral hernia: changes in management owing to concurrent adenoma.
  • Histology revealed acute inflammation and a villous adenoma of the appendix.
  • Villous adenomas of the vermiform appendix are extremely rare tumours of the gastrointestinal tract.
  • This is the first case combining two very rare pathologies--acute appendicitis presenting as strangulated femoral hernia and villous adenoma of the appendix.
  • Second, the presence of an adenoma changes the aetiology of appendicitis.
  • More importantly, changes in surgical management of acute appendicitis presenting as a strangulated femoral hernia owing to a co-existing adenoma are discussed.
  • [MeSH-major] Adenoma, Villous / complications. Appendiceal Neoplasms / complications. Appendicitis / diagnosis. Appendicitis / etiology. Hernia, Femoral / diagnosis

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  • (PMID = 17566835.001).
  • [ISSN] 1265-4906
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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16. Joniau S, Lerut E, Van Poppel H: A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature. Case Rep Med; 2009;2009:818646
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature.
  • We present an exceptional case of a giant urachal tumor, consisting of both villous adenoma and mucinous adenocarcinoma of the urachus.
  • Initial transurethral biopsies showed only a villous adenoma of the urachus.
  • The patient remained free of disease for 50 months of follow-up.
  • Only three previous cases of urachal adenocarcinoma associated with villous adenoma have been described.

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  • [Cites] J Urol. 1978 Feb;119(2):287-8 [633500.001]
  • [Cites] J Urol. 1986 Jun;135(6):1240-4 [3712579.001]
  • [Cites] J Urol. 1984 Jan;131(1):1-8 [6361280.001]
  • [Cites] J Clin Pathol. 2003 Jun;56(6):465-7 [12783975.001]
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  • [Cites] Am J Clin Pathol. 1983 Jun;79(6):728-31 [6846264.001]
  • (PMID = 20182635.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2825668
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17. Lane Z, Hansel DE, Epstein JI: Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder. Am J Surg Pathol; 2008 Sep;32(9):1322-6
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  • [Title] Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder.
  • Also included for comparison were 3 cases, each of bladder villous adenomas and bladder adenocarcinoma in situ.
  • Membranous PSMA staining was evident in an additional 3 tumors, 1 urachal mucinous adenocarcinoma, 1 nonurachal mucinous and signet ring cell adenocarcinoma, and 1 nonurachal villous adenoma.
  • In conclusion, although all cases of bladder adenocarcinoma examined were negative for PSA and PSAP, the surprising finding that a subset of invasive and in situ adenocarcinomas of the bladder demonstrated immunoreactivity for P501S and PSMA should warrant caution when using these markers in differentiating prostatic from bladder adenocarcinomas.
  • The lack of granular perinuclear staining for P501S and the absence of membranous PSMA staining both favor a bladder adenocarcinoma, although rare cases of villous adenoma and adenocarcinoma did show PSMA membranous staining indistinguishable from that seen in prostate cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Villous / metabolism. Antigens, Neoplasm / biosynthesis. Urinary Bladder Neoplasms / metabolism

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  • (PMID = 18670358.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Membrane Proteins; 0 / prostein; EC 3.1.3.2 / Acid Phosphatase; EC 3.1.3.2 / prostatic acid phosphatase; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.4.21.77 / Prostate-Specific Antigen
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18. Genc H, Haciyanli M, Tavusbay C, Colakoglu O, Aksöz K, Unsal B, Ekinci N: Carcinoma arising from villous adenoma of the ampullary bile duct: Report of a case. Surg Today; 2007;37(2):165-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma arising from villous adenoma of the ampullary bile duct: Report of a case.
  • Adenocarcinoma arising from the villous adenoma of the ampullary biliary epithelium is an extremely rare disorder.
  • The preoperative diagnosis and treatment of the disease represent a major difficulty.
  • A frozen-section examination of these particles revealed villous adenoma.
  • The frozen-section examination of the resected material also revealed a villous adenoma.
  • The histological examination revealed a villous adenoma arising from the biliary epithelium and some adenocarcinoma foci.
  • This case shows the importance of surgeons to keep in mind the fact that frozen examinations may sometimes miss a malignancy and they therefore cannot be relied upon to rule out malignancy in villous adenoma of the ampullary bile duct.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Neoplasms, Multiple Primary

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  • (PMID = 17243040.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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19. Koning GG, Rensma PL, van Milligen de Wit AW, van Laarhoven CJ: In-one-continuity rectal excision and anal mucosectomy of a giant villous adenoma: an alternative surgical approach. Case Rep Gastroenterol; 2008;2(2):175-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In-one-continuity rectal excision and anal mucosectomy of a giant villous adenoma: an alternative surgical approach.
  • BACKGROUND: The authors present a woman suffering from McKittrick-Wheelock syndrome (MKWS) with a giant rectal villous adenoma.
  • The most frequently reported tumors are villous adenomas.
  • At colonoscopy an 8-cm villous adenoma was seen in the rectum.

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  • [Cites] Br J Surg. 1980 Sep;67(9):651-2 [7427065.001]
  • [Cites] Rom J Gastroenterol. 2005 Mar;14(1):63-6 [15800695.001]
  • [Cites] Medicina (Kaunas). 2003;39 Suppl 1:48-50 [12761420.001]
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  • [Cites] Prostaglandins. 1992 Jun;43(6):567-72 [1410521.001]
  • [Cites] Med Klin (Munich). 2002 Oct 15;97(10):619-23 [12386796.001]
  • (PMID = 21490885.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075139
  • [Keywords] NOTNLM ; Dehydration / Electrolyte disorders / McKittrick-Wheelock syndrome / Rectal surgery / Rectal villous adenoma / Renal failure
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20. Piana S, Asioli S, Foroni M: Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. Virchows Arch; 2006 Feb;448(2):228-31
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  • [Title] Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features.
  • We describe a case of oncocytic adenocarcinoma of the rectum, associated with a villous adenoma, arising on a 66-year-old man.
  • Superficially, a villous adenoma with high-grade dysplasia was evident; adenomatous cells showed focal eosinophilic changes, consisting of a large granular cytoplasm, an oval atypical nucleus, and a prominent nucleolus.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16450120.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Carcinoembryonic Antigen; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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21. de Decker S, Bovy C, Deflandre J, Moonen M, Van Nes MC: Treatment of a nephrotic syndrome by endoscopic removal of a villous adenoma of the duodenum. Gastroenterol Clin Biol; 2010 Nov;34(11):625-8
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  • [Title] Treatment of a nephrotic syndrome by endoscopic removal of a villous adenoma of the duodenum.
  • We report the case of a patient diagnosed with a villous adenoma of the duodenum showing high degree dysplasia who developed a nephrotic syndrome (NS) due to a membranous nephropathy (MN), demonstrated by renal biopsy.
  • Only the endoscopic resection of the duodenal adenoma could control the NS.
  • [MeSH-major] Adenoma, Villous / surgery. Duodenal Neoplasms / surgery. Duodenoscopy. Nephrotic Syndrome / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20850233.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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22. Cho SD, Herzig DO, Douthit MA, Deveney KE: Treatment strategies and outcomes for rectal villous adenoma from a single-center experience. Arch Surg; 2008 Sep;143(9):866-70; discussion 871-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment strategies and outcomes for rectal villous adenoma from a single-center experience.
  • OBJECTIVES: To analyze a 13-year, single-surgeon experience with villous adenoma of the rectum with respect to procedure, complications, recurrence, and cancer incidence.
  • PATIENTS: Patients who underwent excision of rectal villous adenoma.
  • CONCLUSIONS: Complete excision is warranted for rectal villous adenomas, as biopsies were accurate only 50% of the time, and 1 in 8 patients had unsuspected cancer found after excision.
  • [MeSH-major] Adenoma, Villous / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18794424.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Sung W, Park BD, Lee S, Chang SG: Villous adenoma of the urinary bladder. Int J Urol; 2008 Jun;15(6):551-3
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  • [Title] Villous adenoma of the urinary bladder.
  • Villous adenomas arising in the urinary tract are an uncommon occurrence.
  • Villous adenomas arising in the bladder are rare tumors that have been described as isolated cases and a few case series.
  • We report a new case of a large villous adenoma arising in the bladder that was treated by transurethral resection.
  • [MeSH-major] Adenoma, Villous / diagnosis. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 18489648.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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24. Bosma J, Silvis R: Transanal resection for villous adenomas using the Fansler proctoscope. Acta Chir Belg; 2008 Sep-Oct;108(5):538-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal resection for villous adenomas using the Fansler proctoscope.
  • [MeSH-major] Adenoma, Villous / surgery. Proctoscopes. Rectal Neoplasms / surgery

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  • (PMID = 19051462.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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25. Alexander CL, Urbanski SJ, Hilsden R, Rabin H, MacNaughton WK, Beck PL: The risk of gastrointestinal malignancies in cystic fibrosis: case report of a patient with a near obstructing villous adenoma found on colon cancer screening and Barrett's esophagus. J Cyst Fibros; 2008 Jan;7(1):1-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The risk of gastrointestinal malignancies in cystic fibrosis: case report of a patient with a near obstructing villous adenoma found on colon cancer screening and Barrett's esophagus.
  • We present a 39 year old male CF patient that underwent a colonoscopy for colon cancer screening and a large, near obstructing, villous adenoma of his ileum was found.
  • [MeSH-major] Adenoma, Villous / complications. Barrett Esophagus / complications. Cystic Fibrosis / complications. Ileal Neoplasms / complications
  • [MeSH-minor] Adult. Colonoscopy. Endoscopy, Gastrointestinal. Genetic Predisposition to Disease. Humans. Male. Risk Factors


26. Bhat S, Chandran V: Villous adenoma of the renal pelvis and ureter. Indian J Urol; 2010 Oct;26(4):598-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villous adenoma of the renal pelvis and ureter.
  • Villous adenoma originating in the urinary tract is a rare condition.
  • We are reporting the third case of muconephrosis due to villous adenomatous changes of the renal pelvis and ureter.

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  • [Cites] Am J Surg Pathol. 1999 Jul;23(7):764-71 [10403298.001]
  • [Cites] Urology. 2002 Aug;60(2):344 [12137843.001]
  • [Cites] J Chin Med Assoc. 2007 Jan;70(1):33-5 [17276931.001]
  • (PMID = 21369402.001).
  • [ISSN] 1998-3824
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3034078
  • [Keywords] NOTNLM ; Muconephrosis / villous adenoma
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27. Macher-Goeppinger S, Aulmann S, Haferkamp A, Hohenfellner M, Schirmacher P, Bläker H: [Villous adenoma within an urachal diverticulum associated with long-term mucusuria]. Pathologe; 2008 Jul;29(4):305-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Villous adenoma within an urachal diverticulum associated with long-term mucusuria].
  • After surgical resection histologic examination showed a mucus producing, intestinally differentiated adenoma within the diverticulum.
  • This finding explains both the recurrent infections and the 10-year history of mucusuria.

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  • (PMID = 18274750.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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28. Cubuk R, Tasali N, Arslan G, Midi A, Manukyan MN, Guney S: A giant villous adenoma: case mimicking rectosigmoid malignancy; radiological survey to diagnosis. Prague Med Rep; 2010;111(1):76-81
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  • [Title] A giant villous adenoma: case mimicking rectosigmoid malignancy; radiological survey to diagnosis.
  • Villous adenomas are benign lesions, which are difficult to interpret because of their malignancy potential.
  • Usually, villous adenomas are asymptomatic although they may cause rectal bleeding like malignant tumours.
  • We present a case of giant villous adenoma to evaluate the contribution of its radiological features including double contrast barium enema, computed tomography and magnetic resonance imaging examinations for the differential diagnosis.
  • [MeSH-major] Adenoma, Villous / diagnosis. Colorectal Neoplasms / diagnosis

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  • (PMID = 20359441.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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29. Elwing JE, Gao F, Davidson NO, Early DS: Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women. Am J Gastroenterol; 2006 Aug;101(8):1866-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women.
  • Despite several studies linking insulin resistance to increased CRC risk, there are limited data on colorectal adenoma risk in diabetic women.
  • We hypothesized that diabetic women would have increased rates of colorectal adenomas relative to a group of nondiabetic women.
  • METHODS: Colorectal adenoma rates were determined in 100 estrogen-negative women with type 2 diabetes mellitus and compared with 500 nondiabetic, estrogen-negative controls.
  • Adenomas were defined as any adenoma or advanced adenoma (villous or tubulovillous features, size >1 cm or high-grade dysplasia).
  • A multivariate model including age, race, diabetes, hypertension, hypercholesterolemia, body mass index, and nonsteroidal anti-inflammatory drug status was used to determine the independent effects of diabetes on colorectal adenoma incidence.
  • RESULTS: Diabetics as compared with nondiabetics had greater rates of any adenoma (37%vs 24%, p= 0.009) and advanced adenomas (14%vs 6%, p= 0.009).
  • Two hundred forty-five obese subjects compared with 355 nonobese subjects had a higher rate of any adenoma (32%vs 22%, p= 0.001).
  • Obese diabetics compared with nonobese, nondiabetics had greater rates of any adenoma (42%vs 23%, p< or = 0.001) and advanced adenomas (19%vs 7%, p< or = 0.001).
  • Multivariate analysis showed that adenomas and advanced adenomas were independently predicted by diabetes (p < 0.05) and adenomas by age.
  • DISCUSSION: Women with type 2 diabetes mellitus had higher rates of colorectal adenomas as compared with lean and nondiabetic women.
  • This finding adds to the evidence that type 2 diabetes is an important factor in the progression of the adenoma-carcinoma sequence.

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  • [CommentIn] Am J Gastroenterol. 2007 Feb;102(2):466-7 [17311671.001]
  • [CommentIn] Am J Gastroenterol. 2007 Mar;102(3):692 [17335459.001]
  • (PMID = 16790036.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK056341-05S2; United States / NIDDK NIH HHS / DK / P30 DK056341; United States / NHLBI NIH HHS / HL / HL38180; None / None / / P30 DK056341-06; United States / NIDDK NIH HHS / DK / P30 DK056341-06; United States / NIDDK NIH HHS / DK / DK52574; None / None / / P30 DK056341-05S2; United States / NIDDK NIH HHS / DK / DK56260
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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30. Shivaprakash HN, Jayashree K, Girish M: Villous adenoma: a rare tumor of vaginal vault. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):265-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Villous adenoma: a rare tumor of vaginal vault.
  • Villous adenomas are extremely rare tumors in the vagina and are indistinguishable from their colonic counterparts.
  • We present a case of villous adenoma of vaginal vault, a rare site of presentation in a 30-year-old female.
  • [MeSH-major] Adenoma, Villous / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 18603704.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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31. Arslan N, Dehdashti F, Siegel BA: FDG uptake in colonic villous adenomas. Ann Nucl Med; 2005 Jun;19(4):331-4
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  • [Title] FDG uptake in colonic villous adenomas.
  • Colonic adenomas constitute 70-80% of all colorectal polyps, and their clinical significance relates primarily to their relationship with colorectal cancer.
  • The purpose of this study was to investigate the rate of FDG-PET positivity within colonic villous adenomas.
  • A pathology database search was performed to identify all patients diagnosed with colonic villous adenoma between June 1, 1996 and December 1, 2000.
  • Patients with a pathologic diagnosis of colonic villous adenoma and who also had a FDG-PET study up to 1 month before colonoscopy were included in this study.
  • Of more than 4,000 patients, six patients were diagnosed with colonic adenoma on subsequent colonoscopy following FDG-PET study.
  • Based on the pathological findings, these 6 patients had a total of 2 villous and 9 tubulovillous adenomas.
  • Five of the 6 patients showed foci of increased FDG uptake in the region of the colon that corresponded to the villous adenoma(s) detected on colonoscopy, which accounted for a true-positive rate of 83.3% (5/6 subjects).
  • Focal lesions in the colon seen on FDG-PET examinations need to be investigated further, even though some of these will prove to be villous adenomas rather than colorectal carcinomas.
  • [MeSH-major] Adenoma, Villous / radionuclide imaging. Colorectal Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18 / pharmacokinetics. Positron-Emission Tomography / methods

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  • (PMID = 16097645.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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32. Kakar S, Deng G, Cun L, Sahai V, Kim YS: CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. Hum Pathol; 2008 Jan;39(1):30-6
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  • [Title] CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.
  • We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS mutations and methylation at hMLH1, p16, HIC1, RASSF2, MGMT, MINT1, and MINT31.
  • CIMP-positive status (methylation at 3 or more loci) was observed in 44% tubulovillous/villous adenomas compared with 8 (27%) of 30 tubular adenomas (P = .08).
  • Tubulovillous/villous adenomas showed significantly higher methylation than tubular adenomas at MGMT (87% vs 37%, P < .01) and RASSF2 (94% vs 70%, P = .02).
  • There was no significant difference in methylation of HIC1, MINT1, MINT31, and p16. hMLH1 methylation was absent in all tubulovillous/villous adenomas and seen in only 2 (7%) tubular adenomas.
  • CIMP-positive status correlated with large size, right-sided location, and amount of villous component in tubulovillous/villous adenomas.
  • BRAF V600E mutation was not observed in any tubular adenoma or tubulovillous/villous adenoma.
  • KRAS mutations were seen in 9% of tubulovillous/villous adenomas and 10% of tubular adenomas.
  • In conclusion, CIMP-positive phenotype is common in tubulovillous/villous adenomas and increases with large size, right-sided location, and amount of villous component.
  • Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma.
  • BRAF mutations are absent in tubulovillous/villous adenomas.
  • [MeSH-major] Adenoma, Villous / genetics. Adenoma, Villous / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. CpG Islands. DNA Methylation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. ras Proteins / genetics
  • [MeSH-minor] Disease Progression. Humans. Microsatellite Instability

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  • (PMID = 17950780.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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33. Khvatov AA, Borisov AE, Sherstnova EM, Miaukina LM: [Experience with treatment of patients with villous adenoma of the large intestine]. Vestn Khir Im I I Grek; 2010;169(4):78-9

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  • [Title] [Experience with treatment of patients with villous adenoma of the large intestine].
  • [MeSH-major] Adenoma, Villous / surgery. Colonic Neoplasms / surgery

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  • (PMID = 20973193.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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34. Lee TS, Kim HK, Ahn HM, Lee UJ, Choi YC, John BM, Park TI, Koo JH: [A case of early bile duct cancer arising from villous adenoma in choledochal cyst]. Korean J Gastroenterol; 2009 Jul;54(1):55-9
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  • [Title] [A case of early bile duct cancer arising from villous adenoma in choledochal cyst].
  • Herein, we report a rare case of bile duct adenoma arising from choledochal cyst with anomalous union of pancreaticobiliary duct (AUPBD).
  • On histological examination, adenoma with focal carcinoma change arising from choledochal cyst was diagnosed.
  • [MeSH-major] Adenoma, Villous / diagnosis. Bile Duct Neoplasms / diagnosis. Choledochal Cyst / diagnostic imaging

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  • (PMID = 19696552.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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35. Hurlstone DP, Sanders DS, Cross SS, George R, Shorthouse AJ, Brown S: A prospective analysis of extended endoscopic mucosal resection for large rectal villous adenomas: an alternative technique to transanal endoscopic microsurgery. Colorectal Dis; 2005 Jul;7(4):339-44
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  • [Title] A prospective analysis of extended endoscopic mucosal resection for large rectal villous adenomas: an alternative technique to transanal endoscopic microsurgery.
  • Patients with T2 or node positive disease were referred for surgery.
  • [MeSH-major] Adenoma, Villous / surgery. Colonoscopy / methods. Intestinal Mucosa / surgery. Rectal Neoplasms / surgery

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  • (PMID = 15932555.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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36. Cueto J, Benotto JA, Catalina R, Vazquez-Frias JA: Large duodenal villous adenoma requiring head of the pancreas and pylorus-preserving total duodenectomy. Surg Laparosc Endosc Percutan Tech; 2005 Aug;15(4):230-2; discussion 232-3
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  • [Title] Large duodenal villous adenoma requiring head of the pancreas and pylorus-preserving total duodenectomy.
  • Villous adenomas of the duodenum (VAD) are infrequent lesions of the gastrointestinal tract but have a high risk of recurrence and malignancy.
  • PPTD should be an excellent option in patients with large adenomas because it allows preservation of the pancreas, gastrointestinal function is maintained, the possibility of a recurrence and of an invasive carcinoma of the ampulla is eliminated, and finally because it permits an adequate endoscopic follow-up.
  • [MeSH-major] Adenoma, Villous / surgery. Duodenal Neoplasms / surgery. Duodenum / surgery

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  • (PMID = 16082312.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Katsinelos P, Basdanis G, Chatzimavroudis G, Karagiannoulou G, Katsinelos T, Paroutoglou G, Papaziogas B, Paraskevas G: Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. World J Gastroenterol; 2006 Aug 14;12(30):4927-9
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  • [Title] Pancreatitis complicating mucin-hypersecreting common bile duct adenoma.
  • Villous adenomas of the bile ducts are extremely uncommon.
  • He underwent a modified Whipple operation and histological examination of the surgical specimen showed villous adenoma with rich secretion of mucus.
  • [MeSH-major] Adenoma, Bile Duct / complications. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Mucins / secretion. Pancreatitis / etiology

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  • (PMID = 16937485.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucins
  • [Other-IDs] NLM/ PMC4087637
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38. Akaydin M, Ersoy YE, Erozgen F, Ferlengez E, Kaplan R, Celik A, Memmi N: Tubulovillous adenoma in the common bile duct causing obstructive jaundice. Acta Gastroenterol Belg; 2009 Oct-Dec;72(4):450-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubulovillous adenoma in the common bile duct causing obstructive jaundice.
  • Villous adenomas are benign epithelial lesions with a malignant potential which can occur at any site in the gastrointestinal tract, usually in the rectum and colon, less frequently in the small bowel and very rarely in the biliary tract.
  • Villous adenomas of the extrahepatic bile ducts are exceptional and only a few cases have been reported.
  • Common bile duct (CBD) adenomas often present in a fashion similar to their malignant counterparts, and adenocarcinoma arising from a villous adenoma of the ampullary biliary epithelium is also extremely rare.
  • We present here a tubulovillous adenoma, arising in the common bile duct, as a cause of obstructive jaundice, and discuss the characteristics of these lesions.
  • [MeSH-major] Adenoma, Villous / complications. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology

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  • (PMID = 20163042.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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39. Tomita T: Immunocytochemical localization of lymphatic and venous vessels in colonic polyps and adenomas. Dig Dis Sci; 2008 Jul;53(7):1880-5
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  • [Title] Immunocytochemical localization of lymphatic and venous vessels in colonic polyps and adenomas.
  • Using lymphatic vessels endothelial hyaluronan receptor-1 (LYVE-1) immunocytochemical staining, hyperplastic polyps, tubular adenomas to villous adenomas, were investigated for lymphatic vessels compared with immunostained blood vessels using factor-8.
  • Four cases each of hyperplastic polyps, tubular adenomas to villous adenomas, were routinely fixed in formalin and embedded in paraffin and were immunostained using goat anti-LYVE-1 for lymphatic vessels and rabbit anti-factor-8 for blood vessels.
  • In tubular adenomas, small lymphatic and venous vessels were noted in broad fibrous stalks.
  • In villous adenomas, smaller lymphatic and venous vessels were noted in fine intervillous stroma.
  • In tubular adenomas, small lymphatic and venous vessels were noted in fibrous stalks.
  • In villous adenomas, smaller lymphatic and venous vessels were noted in intervillous stroma.
  • There are no increased lymphatic and venous vessels in intermucosal stroma and stalks of adenomas compared with normal colon.
  • [MeSH-major] Adenoma / blood supply. Colonic Neoplasms / blood supply. Colonic Polyps. Immunohistochemistry / methods. Lymphatic Vessels. Veins

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  • (PMID = 17990106.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / LYVE1 protein, human; 0 / Vesicular Transport Proteins
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40. Kirimlioglu H, Kirimlioglu V, Yilmaz S, Sagir V, Coban S, Turkmen E, Hilmioglu F: Role of matrix metalloproteinase-7 in colorectal adenomas. Dig Dis Sci; 2006 Nov;51(11):2068-72
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  • [Title] Role of matrix metalloproteinase-7 in colorectal adenomas.
  • They are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas.
  • In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of colonic adenomas.
  • Although MMP-7 has already been shown to be overexpressed in various types of colonic adenomas, tubular versus villous adenomas had not been further seperated to date.
  • Seventy-six patients had either normal mucosa (n=15) or tubular (n=32), tubulovillous (n=16), or villous (n=13) colonic adenoma.
  • Each adenoma was graded according to the percentage of strongly stained areas in the adenoma as G0, G1, G2, or G3.
  • Sixty-nine percent of villous adenomas showed grade 3 staining of MMP-7, versus none of the tubular adenomas.
  • G0 and G1 staining was not detected in the villous adenomas.
  • The results of the study show that the degrees of overexpression of the three subtypes of colonic adenomas were statistically significantly different.
  • In conclusion, MMP-7 overexpression is thought to be an early event in the adenoma-carcinoma pathway.
  • [MeSH-major] Adenoma / enzymology. Colorectal Neoplasms / enzymology. Matrix Metalloproteinase 7 / physiology
  • [MeSH-minor] Adenoma, Villous / enzymology. Adenoma, Villous / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies

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  • (PMID = 17009118.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
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41. Carneiro FP, Ramalho LN, Britto-Garcia S, Ribeiro-Silva A, Zucoloto S: Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas. Dis Colon Rectum; 2006 May;49(5):588-94
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  • [Title] Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas.
  • PURPOSE: The aim of this study was to investigate the immunohistochemical expression of p16, p53, and p63 proteins according to some pathologic parameters related to colorectal adenomas and adenocarcinomas such as grade of dysplasia and histologic type.
  • METHODS: Immunohistochemistry with the antibodies p16, p53, and p63 was performed in tubular, tubular-villous, and villous adenomas (n = 30) and in well, moderately, and poorly differentiated adenocarcinomas (n = 30).
  • RESULTS: The p16 and p53 labelings were observed in some adenomas and adenocarcinomas but without any association with p63 expression, histologic type, or grade of differentiation of the neoplasm.
  • P63 expression was found mainly in the villous adenomas and in the poorly differentiated adenocarcinomas.
  • However, p63 expression was closely associated with villous adenomas and poorly differentiated adenocarcinomas.
  • [MeSH-minor] Adenocarcinoma. Adenoma. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. DNA-Binding Proteins. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Keratins / metabolism. Transcription Factors. Tumor Suppressor Proteins

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  • (PMID = 16575619.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 68238-35-7 / Keratins
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42. Artifon EL, Sakai P, Baracat R, Moura EG: Endoscopic ampullectomy in a patient with a duodenal diverticulum. A challenging procedure. Rev Gastroenterol Mex; 2010;75(2):199-202

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  • Biopsy of the ampulla was positive for villous adenoma.
  • [MeSH-major] Adenoma, Villous / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Digestive System

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  • (PMID = 20615792.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
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43. Rubio CA, Nesi G, Messerini L, Zampi GC, Mandai K, Itabashi M, Takubo K: The Vienna classification applied to colorectal adenomas. J Gastroenterol Hepatol; 2006 Nov;21(11):1697-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Vienna classification applied to colorectal adenomas.
  • In this study, that classification is applied to colorectal adenomas.
  • METHODS: Colorectal adenomas from 1552 patients were histologically classified according to the categories listed in Vienna: category 3, low-grade dysplasia; 4.1, high-grade dysplasia; 4.2, carcinoma in situ; 4.3, suspicious of intramucosal carcinoma; 5.1, intramucosal carcinoma; and 5.2, submucosal carcinoma.
  • Adenomas with dysplasia (categories 3 and 4.1) or with carcinoma (categories 4.2, 4.3, 5.1 and 5.2) were analyzed separately.
  • On basis of their configuration, adenomas were classified into tubular, tubulovillous, villous, serrated, microtubular and combined phenotypes (i.e. other than tubulovillous).
  • RESULTS: The highest percentage of adenomas with carcinoma was found amongst villous adenomas (29.6%), followed by combined adenomas (27.8%).
  • Villous adenoma with carcinoma was the most frequent neoplasia at all ages; combined adenomas with carcinoma were more frequent among younger patients.
  • In elderly patients (> or = 60 years of age) the highest percentage of adenomas with carcinoma was recorded in villous adenomas (28.1%), followed by serrated adenomas (19.2%).
  • Villous adenomas and combined adenomas with carcinoma were more frequent in males.
  • CONCLUSION: The Vienna classification of colorectal adenomas seems to be influenced by parameters inherent to the patient such as age and sex and by the histological phenotype of the adenoma.
  • [MeSH-major] Adenoma / classification. Colorectal Neoplasms / classification

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  • (PMID = 16984592.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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44. Lepur D, Klinar I, Mise B, Himbele J, Vranjican Z, Barsić B: McKittrick-Wheelock syndrome: a rare cause of diarrhoea. Eur J Gastroenterol Hepatol; 2006 May;18(5):557-9
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  • The most frequently reported tumours are villous adenomas.

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  • [CommentIn] Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1047-51 [16957509.001]
  • (PMID = 16607156.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isotonic Solutions
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45. Zheng YF, Yang J, Zhao XJ, Feng B, Kong HW, Chen YJ, Lv S, Zheng MH, Xu GW: Urinary nucleosides as biological markers for patients with colorectal cancer. World J Gastroenterol; 2005 Jul 7;11(25):3871-6
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  • METHODS: The concentrations of 14 kinds of urinary nucleosides from 52 patients with colorectal cancer, 10 patients with intestinal villous adenoma and 60 healthy adults were determined by column switching high performance liquid chromatography method.
  • RESULTS: The mean levels of 12 kinds of urinary nucleosides (except uridine and guanosine) in the patients with colorectal cancer were significantly higher than those in patients with intestinal villous adenoma or the healthy adults.
  • Only 10% (1/10) of patients with intestinal villous adenoma were indistinguishable from patients with colorectal cancer.

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  • (PMID = 15991285.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nucleosides
  • [Other-IDs] NLM/ PMC4504888
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46. Lana E, Brun ME, Rivals I, Selves J, Kirzin S, Lutsyk AP, Gordiyuk VV, Bibeau F, Rynditch A, De Sario A: BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas. Cancers (Basel); 2009;1(1):3-11

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  • [Title] BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas.
  • In this study, we show that hypomethylation of BAGE loci was an early event that occurred in 43% of colorectal adenomas.
  • Interestingly, hypomethylation of BAGE loci was frequent (50%) in tubulo-villous and villous adenomas, these adenomas having a high probability of being transformed into colorectal cancers.

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  • (PMID = 24280968.001).
  • [ISSN] 2072-6694
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3757347
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47. Buresi MC, Zandieh I, Nagy AG, Spielmann A, Yee WC, Weiss AA, Yoshida EM: The use of endoscopic ultrasonography and other imaging modalities in the preoperative staging of rectal villous tumours: a case of overstaging by magnetic resonance imaging. Can J Gastroenterol; 2009 Sep;23(9):639-41

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  • [Title] The use of endoscopic ultrasonography and other imaging modalities in the preoperative staging of rectal villous tumours: a case of overstaging by magnetic resonance imaging.
  • A case of a 60-year-old man with recurrent rectal villous adenoma is described.
  • The surgical pathology specimen revealed a villous adenoma with lowgrade dysplasia but no carcinoma and no extension into the muscularis propria.
  • [MeSH-major] Adenoma, Villous / diagnosis. Endosonography. Rectal Neoplasms / diagnosis

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  • [Cites] ANZ J Surg. 2006 Jun;76(6):497-504 [16768778.001]
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  • (PMID = 19816630.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2776556
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48. Galamb O, Sipos F, Spisák S, Galamb B, Krenács T, Valcz G, Tulassay Z, Molnár B: Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genes. Cell Oncol; 2009;31(1):19-29
The Lens. Cited by Patents in .

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  • [Title] Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genes.
  • BACKGROUND: As most colorectal cancers (CRC) develop from villous adenomas, studying alterations in gene expression profiles across the colorectal adenoma-dysplasia-carcinoma sequence may yield potential biomarkers of disease progression.
  • METHODS: Total RNA was extracted, amplified, and biotinylated from colonic biopsies of 15 patients with CRC, 15 with villous adenoma and 8 normal controls.
  • Gene expression profiles were evaluated using HGU133Plus2.0 microarrays and disease progression associated data were validated with RT-PCR.
  • RESULTS: 17 genes were validated to show sequentially altered expression at mRNA level through the normal-adenoma-dysplasia-carcinoma progression.
  • CONCLUSIONS: Downregulated AMN and PTGDR and upregulated osteopontin and osteonectin were found as potential biomarkers of colorectal carcinogenesis and disease progression to be utilized for prospective biopsy screening both at mRNA and protein levels.
  • [MeSH-major] Adenoma / genetics. Biomarkers, Tumor / genetics. Colorectal Neoplasms / genetics. Disease Progression. Gene Expression Profiling. Gene Expression Regulation

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  • (PMID = 19096147.001).
  • [ISSN] 1875-8606
  • [Journal-full-title] Cellular oncology : the official journal of the International Society for Cellular Oncology
  • [ISO-abbreviation] Cell. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC4618585
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49. Lemyé AC, Guy-Viterbo V, van Vyve E: Adenocarcinoma of the duodenum arising in a tubulo-villous adenoma. Acta Chir Belg; 2009 Jan-Feb;109(1):95-7
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  • [Title] Adenocarcinoma of the duodenum arising in a tubulo-villous adenoma.
  • Villous adenoma of the duodenum is rare and has a high prevalence of cancer.
  • We report here an unusual case of a 73-year-old man who presented with a tumour on the second part of the duodenum with moderate dysplasia of a tubulo-villous adenoma at the biopsies.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 19341205.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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50. Thomas AA, Rackley RR, Lee U, Goldman HB, Vasavada SP, Hansel DE: Urethral diverticula in 90 female patients: a study with emphasis on neoplastic alterations. J Urol; 2008 Dec;180(6):2463-7
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  • The most common clinical finding was urinary incontinence (29 of 78 women or 37%).
  • Superficial changes associated with invasive carcinoma included villous adenoma in 1 case, intestinal metaplasia in 2 and high grade dysplasia in 3.
  • Of the 90 patients the remaining 82 demonstrated benign findings, including nephrogenic adenoma in 10 (11%).
  • In 2 patients with invasive adenocarcinoma metastatic disease subsequently developed, of which they died.
  • Due to the risk of malignancy in a subset of patients careful clinical examination and followup are warranted in all patients to exclude neoplastic disease.

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  • (PMID = 18930487.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Zhou ZY, Han Y, Wang LP: [BRAF mutation in colorectal serrated lesions]. Zhonghua Yi Xue Za Zhi; 2008 Dec 30;88(48):3411-4
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  • METHODS: 75 paraffin-embedded tissue samples, including 15 cases of Sca, 20 cases of traditional serrated adenoma (TSA), 20 cases of non-serrated adenocarcinoma (NS-ca), and 20 cases of villous adenoma, were reviewed.
  • However, no BRAF V600E mutation was found in the 14 NS-ca samples and the 11 villous adenoma specimens.
  • The BRAF V600E mutation frequencies of the villous adenoma group and NS-ca group were significantly lower than those of the TSA group and Sca group (P = 0.0084); however, there was no statistical difference in the frequency of BRAF V600E mutation between the Sca and TSA groups (P > 0.05).
  • CONCLUSION: BRAF V600E mutation frequency is significantly higher in the Sca and TSA patients than in the NS-ca and villous adenoma patients.
  • There is actually a new serrated neoplasia pathway different from the traditional adenoma-carcinoma carcinogenesis pathway.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 19159571.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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52. Wang LP, Chen J, Ning HY, Zhang XZ, Cheng J, Li L, Wang B, Dai XJ, Zhu HY, Miao JH, Wang L: [Serrated lesions of colon and their malignant potential]. Zhonghua Bing Li Xue Za Zhi; 2010 Jul;39(7):447-51
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  • OBJECTIVE: To study the serrated lesions of colon and to compare the malignant potential between traditional serrated adenomas (TSA) and conventional adenomas (CAD).
  • One hundred and eighty-seven cases of CAD (including 160 cases of tubular adenoma and 27 cases of villous adenoma) and 36 cases of invasive adenocarcinoma were randomly selected as the controls.
  • RESULTS: Amongst the 5347 colorectal polyps studied, 258 cases (4.8%) of serrated lesions were found, which included 112 cases (43.4%, 112/258) of hyperplastic polyp, 78 cases (30.2%, 78/258) of TSA and 26 cases (10.1%, 26/258) of sessile serrated adenoma.
  • [MeSH-major] Adenoma / pathology. Cell Transformation, Neoplastic / pathology. Colorectal Neoplasms / pathology. Intestinal Polyps / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma, Villous / classification. Adenoma, Villous / metabolism. Adenoma, Villous / pathology. Colonic Polyps / metabolism. Colonic Polyps / pathology. Humans. Ki-67 Antigen / metabolism. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Rectum / pathology. Retrospective Studies. Tumor Suppressor Protein p53 / metabolism. beta Catenin / metabolism

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  • (PMID = 21055172.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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53. Miles LF, Wakeman CJ, Farmer KC: Giant villous adenoma presenting as McKittrick-Wheelock syndrome and pseudo-obstruction. Med J Aust; 2010 Feb 15;192(4):225-7
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  • [Title] Giant villous adenoma presenting as McKittrick-Wheelock syndrome and pseudo-obstruction.
  • McKittrick-Wheelock syndrome is a rare but recognised complication of hypersecretory rectosigmoid villous adenoma.
  • [MeSH-major] Acute Kidney Injury / etiology. Adenoma, Villous / complications. Colonic Neoplasms / complications. Colonic Pseudo-Obstruction / etiology. Water-Electrolyte Imbalance / etiology

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  • (PMID = 20170462.001).
  • [ISSN] 0025-729X
  • [Journal-full-title] The Medical journal of Australia
  • [ISO-abbreviation] Med. J. Aust.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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54. Yasugi A, Matsuoka H, Otani H, Maeda K, Matsumoto K, Koda M, Kawaguchi K, Harada K, Yashima K, Murawaki Y, Horie Y: [Case of villous tumor of the rectum presenting with severe diarrhea and electrolyte depletion syndrome]. Nihon Shokakibyo Gakkai Zasshi; 2009 Mar;106(3):377-82
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  • [Title] [Case of villous tumor of the rectum presenting with severe diarrhea and electrolyte depletion syndrome].
  • Colonoscopy revealed large tumor with a villous structure in the rectum.
  • The histopathological diagnosis was adenocarcinoma with villous adenoma.
  • [MeSH-major] Adenoma, Villous / complications. Diarrhea / etiology. Rectal Neoplasms / complications. Water-Electrolyte Imbalance / etiology

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  • (PMID = 19262051.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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55. Gracia Solanas JA, Ramírez Rodríguez JM, Aguilella Diago V, Elía Guedea M, Martínez Díez M: A prospective study about functional and anatomic consequences of transanal endoscopic microsurgery. Rev Esp Enferm Dig; 2006 Apr;98(4):234-40
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  • INTRODUCTION: transanal endoscopic microsurgery (TEM) was developed in 1983 by Büess as a minimally invasive technique to manage rectal villous adenomas and early rectal adenocarcinomas.
  • RESULTS: 32 patients (80%) had villous adenomas and 8 patients (20%) had adenocarcinomas (uT1).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Microsurgery / methods. Proctoscopy. Rectal Neoplasms / surgery

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  • (PMID = 16792452.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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56. Jones M, Helliwell P, Pritchard C, Tharakan J, Mathew J: Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship? World J Surg Oncol; 2007;5:51
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  • METHODS: Paraffin processed colonic tissue blocks of normal colonic mucosa (n = 60), and patients diagnosed as adenoma (n = 60), and adenocarcinoma (n = 60) were retrieved from our archive; the adenoma group included tubular (n = 20), tubulovillous (n = 20) and villous adenomas (n = 20).
  • RESULTS: Significant numbers of Helicobacter pylori were identified in tubular adenomas (OR = 11.13; 95%CI = 1.62-76.70), tubulovillous adenomas (OR = 10.45; 95%CI = 1.52-71.52) and adenocarcinomas (OR = 8.13; 95%CI = 1.40-46.99) compared to controls: there was no association in numbers of Helicobacter pylori and villous adenomas (OR = 2.95; 95%CI = 0.29-9.96).
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / microbiology. Adenoma / epidemiology. Adenoma / microbiology. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Female. Humans. Incidence. Intestinal Mucosa / microbiology. Intestinal Mucosa / pathology. Male. Middle Aged. Odds Ratio. Pilot Projects. Reference Values. Risk Assessment. Sampling Studies. Sensitivity and Specificity

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  • (PMID = 17498313.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Bacterial
  • [Other-IDs] NLM/ PMC1885433
  • [General-notes] NLM/ Original DateCompleted: 20070807
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57. Park ET, Oh HK, Gum JR Jr, Crawley SC, Kakar S, Engel J, Leow CC, Gao WQ, Kim YS: HATH1 expression in mucinous cancers of the colorectum and related lesions. Clin Cancer Res; 2006 Sep 15;12(18):5403-10
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  • EXPERIMENTAL DESIGN: Immunohistochemistry and confocal microscopy was used to examine HATH1 expression and subcellular distribution in normal colon and small intestine, mucinous cancers, signet ring carcinomas, and nonmucinous cancers and in precursor lesions, including hyperplastic polyps, serrated adenomas, tubular adenomas, and villous adenomas.
  • HATH1 was found to be strongly expressed in the nuclei of hyperplastic polyps, serrated adenomas, villous adenomas, mucinous cancers, and signet ring carcinomas but repressed in nonmucinous cancers and tubular adenomas.
  • In addition, the expression of HATH1 in hyperplastic polyps, serrated adenomas, and villous adenomas lends support to the hypothesis that these neoplasms are frequent precursors in mucinous cancer and signet ring carcinoma development.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Humans. Intestinal Polyps / pathology. Intestines / cytology. Intestines / ultrastructure. Male. Microscopy, Fluorescence. Middle Aged. Mucin-2. Mucins / metabolism. Promoter Regions, Genetic. Tissue Distribution. Transcriptional Activation

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  • (PMID = 17000673.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATOH1 protein, human; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / MUC2 protein, human; 0 / Muc2 protein, mouse; 0 / Mucin-2; 0 / Mucins
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58. Zhang X, Leav I, Revelo MP, Deka R, Medvedovic M, Jiang Z, Ho SM: Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon. PLoS Genet; 2009 Jan;5(1):e1000334
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  • By using a panel of immunostained-laser-capture-microdissected clinical samples comprising the entire colon adenoma-carcinoma sequence, we show that deregulation of AMACR during colon carcinogenesis involves two nonrandom events, resulting in the mutually exclusive existence of double-deletion at CG3 and CG10 and deletion of CG12-16 in a newly identified CpG island within the core promoter of AMACR.
  • It existed in histologically normal colonic glands and tubular adenomas with low AMACR expression and was absent in villous adenomas and all CCas expressing variable levels of AMACR.
  • [MeSH-minor] Adenoma, Villous / genetics. Adenoma, Villous / metabolism. Adenoma, Villous / pathology. Base Sequence. Binding Sites. Cell Differentiation. Cell Line, Tumor. Humans. Molecular Sequence Data. Polymorphism, Genetic. Repressor Proteins / metabolism. Sequence Deletion / genetics. Transcription, Genetic

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  • (PMID = 19148275.001).
  • [ISSN] 1553-7404
  • [Journal-full-title] PLoS genetics
  • [ISO-abbreviation] PLoS Genet.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA112532; United States / NCI NIH HHS / CA / R01 CA112532; United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NCI NIH HHS / CA / R01 CA015776; United States / NCI NIH HHS / CA / CA015776; United States / NCI NIH HHS / CA / R01 CA062269; United States / NCI NIH HHS / CA / CA062269
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Repressor Proteins; 0 / ZNF202 protein, human; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
  • [Other-IDs] NLM/ PMC2613032
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59. Wang TD, Friedland S, Sahbaie P, Soetikno R, Hsiung PL, Liu JT, Crawford JM, Contag CH: Functional imaging of colonic mucosa with a fibered confocal microscope for real-time in vivo pathology. Clin Gastroenterol Hepatol; 2007 Nov;5(11):1300-5
Hazardous Substances Data Bank. D&C Yellow No. 8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND & AIMS: Histologic interpretation of disease currently is performed with static images of excised tissues, and is limited by processing artifact, sampling error, and interpretive variability.
  • RESULTS: Normal mucosa showed circular crypts with uniform size, hyperplasia revealed proliferative glands with serrated lumens, and adenomas displayed distorted elongated glands.
  • For t greater than 5 seconds, high sensitivity, specificity, and accuracy was achieved using a discriminant function to evaluate the contrast ratio to distinguish normal from lesional mucosa (91%, 87%, and 89%, respectively; P < .001), hyperplasia from adenoma (97%, 96%, and 96%, respectively; P < .001), and tubular from villous adenoma (100%, 92%, and 93%, respectively; P < .001).

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  • (PMID = 17936692.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK067618-04; United States / NIDDK NIH HHS / DK / K08 DK067618; United States / NCI NIH HHS / CA / U54 CA105296; United States / NIDDK NIH HHS / DK / K08 DK067618-05; United States / NIDDK NIH HHS / DK / DK067618-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; TPY09G7XIR / Fluorescein
  • [Other-IDs] NLM/ NIHMS34014; NLM/ PMC2104519
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60. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • Adenomatous polyps have been classified into three histologic types; tubular, tubulovillous, and villous with increasing malignant potential.
  • A germline variant G9055A in the MT-ATP 6 gene had a frequency of 100% (17/17) in tubular and 57% (13/23) in villous adenomas; no corresponding variant was in tubulovillous adenomas.
  • Furthermore, A9006G variant at MT-ATP 6 gene was observed at frequency of 57% (13/23) in villous adenomas only.
  • Interestingly, variants A9006G and G9055A were absent in the villous tissue samples that were clinicopathological designated as "polyvillous adenomas".
  • [MeSH-minor] Aged. Biopsy. DNA Mutational Analysis. Databases, Genetic. Disease Progression. Humans. Middle Aged. Polymerase Chain Reaction. Prognosis

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  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
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61. Cavallini M, Cavaniglia D, Felicioni F, Vitale V, Pilozzi E, Ziparo V: Large periampullary villous tumor of the duodenum. J Hepatobiliary Pancreat Surg; 2007;14(5):526-8
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  • [Title] Large periampullary villous tumor of the duodenum.
  • A 67-year-old woman, who had symptoms of epigastric pain and abdominal distension, was found, on endoscopy, to have a large sessile villous adenoma of the periampullary duodenum.
  • Because there is no general consensus on the optimal surgical procedure for the treatment of villous tumors of the duodenum, especially for the early stages, the indications for the operative procedure are discussed, based on a review of the literature.
  • [MeSH-major] Adenoma, Villous / surgery. Ampulla of Vater. Duodenal Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17909726.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Rehani B, Chasen RM, Dowdy Y, Bharija A, Satter M, Strohmeyer P, Mantil J: Advanced adenoma diagnosis with FDG PET in a visibly normal mucosa: a case report. J Med Case Rep; 2007;1:99

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advanced adenoma diagnosis with FDG PET in a visibly normal mucosa: a case report.
  • Motivated by the PET scan finding, the colonoscopist performed a biopsy which revealed a villous adenoma without high grade dysplasia.
  • Pathology from tissue extracted during an exploratory laparatomy completed one month later found the lesion to be a villous adenoma with high grade dysplasia.
  • CONCLUSION: Whole-body FDG PET scan revealed the biochemical metabolic changes in malignancy that preceded the appearance of any gross anatomical abnormality.

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  • (PMID = 17883865.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2040155
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63. Radovanovic-Dinic B, Nagorni A, Katic V, Stamenkovic I, Zlatic A: An immunohistochemical study of Ki-67 in colorectal adenoma. Med Arh; 2009;63(1):16-8
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  • [Title] An immunohistochemical study of Ki-67 in colorectal adenoma.
  • The cell proliferation and kinetics of normal gastrointestinal tract are well known but the cell kinetics of adenoma in gastrointestinal tract is poorly understood.
  • The aim of this study was to provide an immunohistochemical evaluation of the expression of Ki-67 antigen in different colorectal adenomas.
  • MATERIAL AND METHODS: In the prospective study, we analyzed 65 colorectal adenomas.
  • RESULTS: Proliferation indexes were found to steadily increase from normal mucosa to adenoma (p < 0.05).
  • There was also a difference in the expression of Ki-67 between adenomas smaller and larger than 10 mm (p < 0.05).
  • The expression of Ki-67 was strongly more often in villous adenomas as opposed to the tubular adenomas (p < 0.05).
  • Reaction for Ki-67 were strong in adenomas with high grade atypia compared to low grade adenomas (p < 0.001).
  • CONCLUSION: The expression of Ki-67 clearly shows differences between advanced and nonadvanced adenomas.
  • The strong reactions of Ki-67 in adenomas with severe dysplasia show a close association with colorectal carcinoma.
  • [MeSH-major] Adenoma / metabolism. Colorectal Neoplasms / metabolism. Ki-67 Antigen / metabolism

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  • (PMID = 19419120.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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64. Qiu HZ, Lin GL, Wu B, Xiao Y: [Transsphincteric surgery of rectal lesions: a report of 120 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 Mar;9(2):114-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: There were 61 cases with villous adenoma including 26 with cancerization, 25 cases with rectal cancer including 16 cases with early rectal cancer, and 17 with submucosal tumor.

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  • (PMID = 16555147.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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65. Guan JT, Wang L, Wang Y, Li Y, Wang R, Zhang WY, Zhan L, Zhou ZG: [Expression of AIF and caspase-3 in colorectal carcinoma, adenoma, and normal mucosa and its correlation]. Zhonghua Wei Chang Wai Ke Za Zhi; 2009 Jul;12(4):391-4
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  • [Title] [Expression of AIF and caspase-3 in colorectal carcinoma, adenoma, and normal mucosa and its correlation].
  • OBJECTIVE: To investigate the expression differences of apoptosis-inducing factor (AIF) and caspase-3 among colorectal carcinoma, adenoma and normal mucosa, and to identify the relationship between AIF and caspase-3 expression in colorectal adenoma-carcinoma sequence.
  • METHODS: Formalin-fixed paraffin embedded colorectal tissues from 174 cases, including 84 adenomas, 72 carcinomas, and 18 normal mucosa, were examined for expression of AIF and caspase-3 by streptavidin-peroxidase (SP) immunohistochemistry.
  • RESULTS: The positive rates of AIF and caspase-3 in colorectal adenoma were higher than those in normal mucosa (P <0.05).
  • The positive rate of AIF in adenoma showed no significant difference compared to colorectal carcinoma (P >0.05).
  • However, caspase-3 expression in adenomas was significantly higher than that in carcinoma (P <0.05).
  • The positive rate of AIF in tubular adenoma was significantly higher than that in villous adenoma (P <0.05), while the positive expression rate of caspase-3 in the two types of adenoma showed no significant difference (P >0.05).
  • [MeSH-major] Adenoma / metabolism. Apoptosis Inducing Factor / metabolism. Caspase 3 / metabolism. Colorectal Neoplasms / metabolism. Intestinal Mucosa / metabolism

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  • (PMID = 19598027.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Apoptosis Inducing Factor; EC 3.4.22.- / Caspase 3
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66. Winstanley V, Little MA, Wadsworth C, Cohen P, Martin NM: The McKittrick-Wheelock syndrome: a case of acute renal failure due to neoplastic cholera. Ren Fail; 2008;30(4):469-73
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  • A large rectal villous adenoma was discovered on sigmoidoscopy, and definitive management was achieved by removal of the tumor.
  • [MeSH-major] Acute Kidney Injury / etiology. Adenoma, Villous / pathology. Cholera / complications. Rectal Neoplasms / pathology. Water-Electrolyte Imbalance / diagnosis

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  • (PMID = 18569924.001).
  • [ISSN] 1525-6049
  • [Journal-full-title] Renal failure
  • [ISO-abbreviation] Ren Fail
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Popescu A, Orban-Schiopu AM, Becheanu G, Diculescu M: McKittrick-Wheelock syndrome - a rare cause of acute renal failure. Rom J Gastroenterol; 2005 Mar;14(1):63-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: Fluid and electrolyte hypersecretion in the villous adenoma of the rectum is presented in the case of a 74 year old man presenting with a severe fluid imbalance.
  • At sigmoidoscopy, a 6/4 cm villous adenoma of the rectum was found.
  • The surgical removal of the adenoma led to complete recovery of the symptoms.
  • [MeSH-major] Acute Kidney Injury / etiology. Adenoma / complications. Rectal Neoplasms / complications

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  • (PMID = 15800695.001).
  • [ISSN] 1221-4167
  • [Journal-full-title] Romanian journal of gastroenterology
  • [ISO-abbreviation] Rom J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Electrolytes
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68. Benes Z, Antos Z: Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy. Anticancer Res; 2009 Nov;29(11):4737-9

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  • One villous adenoma could not be optically analyzed due to friability.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy / methods. Colonic Neoplasms / diagnosis. Colonic Neoplasms / pathology. Colonoscopy / methods. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Middle Aged. Optics and Photonics / methods. Prospective Studies

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  • (PMID = 20032428.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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69. Lieberman DA, Weiss DG, Harford WV, Ahnen DJ, Provenzale D, Sontag SJ, Schnell TG, Chejfec G, Campbell DR, Kidao J, Bond JH, Nelson DB, Triadafilopoulos G, Ramirez FC, Collins JF, Johnston TK, McQuaid KR, Garewal H, Sampliner RE, Esquivel R, Robertson D: Five-year colon surveillance after screening colonoscopy. Gastroenterology; 2007 Oct;133(4):1077-85
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  • Advanced neoplasia was defined as tubular adenoma greater than > or =10 mm, adenoma with villous histology, adenoma with high-grade dysplasia, or invasive cancer.
  • The relative risk in patients with baseline neoplasia was 1.92 (95% CI: 0.83-4.42) with 1 or 2 tubular adenomas <10 mm, 5.01 (95% CI: 2.10-11.96) with 3 or more tubular adenomas <10 mm, 6.40 (95% CI: 2.74-14.94) with tubular adenoma > or =10 mm, 6.05 (95% CI: 2.48-14.71) for villous adenoma, and 6.87 (95% CI: 2.61-18.07) for adenoma with high-grade dysplasia.
  • Patients with 1 or 2 tubular adenomas less than 10 mm represent a low-risk group compared with other patients with colon neoplasia.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Mass Screening / methods
  • [MeSH-minor] Aged. Disease Progression. Follow-Up Studies. Hospitals, Veterans. Humans. Incidence. Middle Aged. Neoplasm Invasiveness. Practice Guidelines as Topic. Predictive Value of Tests. Prognosis. Prospective Studies. Recurrence. Risk Assessment. Risk Factors. Time Factors. United States / epidemiology

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  • [CommentIn] Gastroenterology. 2007 Oct;133(4):1364-7 [17919505.001]
  • (PMID = 17698067.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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70. Rubio CA, Stemme S, Jaramillo E, Lindblom A: Hyperplastic polyposis coli syndrome and colorectal carcinoma. Endoscopy; 2006 Mar;38(3):266-70
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  • Other colorectal lesions were found as follows: two patients each had one mixed polyp; there were 15 serrated adenomas in eight patients; and there were 30 tubular, tubulovillous, or villous adenomas in eight patients.
  • Of the four villous adenomas, three were associated with a CRC, but only one of the 15 serrated adenomas was associated with a CRC.
  • [MeSH-minor] Adenoma / pathology. Aged. Colonic Neoplasms / pathology. Female. Humans. Hyperplasia. Male. Middle Aged

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  • (PMID = 16528654.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 35
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71. Rubio CA: Neoplasias of the colorectal crypts. Anticancer Res; 2005 Nov-Dec;25(6C):4551-8
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  • Colorectal cancers are often preceded by noninvasive neoplasias arising in the surface epithelium, namely tubular, tubulovillous and villous adenomas.
  • The material included 502 adenomas, 865 invasive tumours and 221 cases of ulcerative colitis (UC).
  • Over the 5-year period, the most frequent phenotype encountered was single crypt dysplasia (in all 5 colectomies from familial adenomatous polyposis patients), followed by serrated adenomas (11.2%), hyperplastic polyps (8.4%), dysplasia in UC (6.3%), pure carcinoid tumours (1.7%), signet ring cell carcinoma (1.1%), adenocarcinoid tumours (0.2%) and de novo carcinomas (0.1%).
  • In this survey, no case of Paneth cell adenoma or of cryptal neoplasia in lymphoid-associated mucosa (also known to originate from the crypts) was found.
  • [MeSH-minor] Adenoma / pathology. Adenomatous Polyposis Coli / pathology. Female. Goblet Cells / pathology. Humans. Intestinal Mucosa / pathology. Male. Paneth Cells / pathology

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  • (PMID = 16334140.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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72. Terkivatan T, den Hoed PT, Lange JF Jr, Koot VC, van Goch JJ, Veen HF: The place of the posterior surgical approach for lesions of the rectum. Dig Surg; 2005;22(1-2):86-90

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  • BACKGROUND: Although there are many advantages of a posterior approach to rectal disease, these procedures are not widely accepted because many surgeons fear the postoperative complications.
  • Indications for surgery were benign lesions (n = 33), e.g. villous adenoma, rectal prolapse and endometriosis as well as invasive adenocarcinoma (n = 24).
  • During a mean follow-up of 29 (range 2-86) months, 3 patients with a villous adenoma and 2 patients who were treated for a malignant lesion had a locally recurrent lesion.
  • [MeSH-minor] Adenoma, Villous / surgery. Aged. Aged, 80 and over. Endometriosis / surgery. Female. Humans. Male. Middle Aged. Prolapse. Rectal Diseases / surgery

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  • (PMID = 15849468.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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73. Korula A, Thomas M, Noronha J: Acquired perforating dermatosis: an innocuous lesion with possibly ominous implications. Cutis; 2010 Nov;86(5):242-4
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  • Acquired perforating dermatosis encompasses several specific disease entities occurring in adults that often have overlapping clinical and histologic features.
  • We describe a case of acquired perforating dermatosis presenting as the first symptom in a 64-year-old man who also was diagnosed to have mild obstructive jaundice due to a periampullary villous adenoma with high-grade dysplasia.
  • [MeSH-major] Adenoma, Villous / diagnosis. Duodenal Neoplasms / diagnosis. Skin Diseases / diagnosis

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  • (PMID = 21214124.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Kiziltaş S, Sezgin Ramadan S, Topuzoğlu A, Küllü S: Does the severity of tissue eosinophilia of colonic neoplasms reflect their malignancy potential? Turk J Gastroenterol; 2008 Dec;19(4):239-44
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  • This retrospective study aimed to investigate the frequency and intensity of tissue eosinophilia in various colonic neoplasms, including serrated adenomas.
  • METHODS: We evaluated 448 colonic neoplasms to determine eosinophilic infiltration: 96 hyperplastic polyps, 50 serrated adenomas, 19 flat adenomas, 154 tubular adenomas, 71 tubulovillous adenomas, 13 villous adenomas and 45 adenocarcinomas.
  • RESULTS: Moderate (46.7%) and marked (52.9%) intensity were noted in all colonic adenomas.
  • Mostly moderate eosinophilic infiltration was observed in serrated adenomas.
  • CONCLUSIONS: Our findings suggest that the intensity of tissue eosinophilia is most prominent in adenomas including serrated adenomas and is diminished from adenoma to carcinoma.
  • This finding may be used as a diagnostic indicator.

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  • (PMID = 19119482.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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75. Li FE, Ye HJ, Li J, Wang JP, Liu YG, Yu GY, Yin WH: [Clinical, enteroscopic, and pathological characteristics of 796 cases of colorectal polyps]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2005 Aug;30(4):463-6
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  • The canceration rates in villous, mixed and tubular adenomas were 29.73%, 11.11%, and 4.86%.
  • There is a high canceration of polyps in the left colon, villous adenomas and > or = 2.0 cm polyps.
  • [MeSH-minor] Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Cell Transformation, Neoplastic / pathology. Child. Child, Preschool. Female. Humans. Male

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  • (PMID = 16190400.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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76. Guan J, Chen J, Luo YF, Cao JL, Zhao H, Hao J: [Expression of survivin in colorectal adenoma and adenocarcinoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2007 Jun;29(3):398-401
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  • [Title] [Expression of survivin in colorectal adenoma and adenocarcinoma].
  • METHODS Immunohistochemistry staining was performed by two-step EnVision technique for the paraffin sections, which included 90 adenomas, 25 ademomas with high-grade glandular intraepithelial neoplasia, and 108 colorectal adenocarcinomas.
  • The positive rate of SVV in tubular adenomas, villous adenomas, and tubulovillous adenomas were 30% (12/40), 40.9% (9/22), and 35.8% (10/28), respectively.
  • The positive rate of SVV in tubulovillous adenomas with high-grade glandular intraepithelial neoplasia were 68% (17/25).
  • SVV expressions among the three types of adenomas without neoplasia were not significantly different (P > 0.05).
  • SVV expression between each type of the above-mentioned ademoma and tubulovillous adenoma with high-grade glandular intraepithelial neoplasia or different Dukes stages of colorectal carcinoma was significantly different (P < 0.05).
  • SVV expressions in adenocarcinomas and adenomas with high grade glandular intraepithelial neoplasia were significantly higher than those in adenomas (P < 0.01).
  • SVV expression may be useful to distinguish adenocarcinoma from adenoma in colorectal carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Microtubule-Associated Proteins / biosynthesis

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  • (PMID = 17633470.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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77. Psofaki V, Kalogera C, Tzambouras N, Stephanou D, Tsianos E, Seferiadis K, Kolios G: Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas. World J Gastroenterol; 2010 Jul 28;16(28):3553-60
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  • [Title] Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.
  • METHODS: DNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1 (hMLH1), Cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), and O-6-methylguanine DNA methyltransferase (MGMT), as well as their relation to MSI.
  • RESULTS: The frequency of promoter methylation for each locus increased in the sequence healthy tissue/adenoma/carcinoma.
  • MGMT and CDKN2A/p16 presented a statistically significant increase in promoter methylation between the less and more tumorigenic forms of colorectal adenomas (tubular vs tubullovillous and villous adenomas).
  • All patients with tubulovillous/villous adenomas, as well as all colorectal cancer patients, showed promoter methylation in at least one of the examined loci.
  • These findings suggest a potentially crucial role for methylation in the polyp/adenoma to cancer progression in colorectal carcinogenesis.
  • CONCLUSION: Methylation analysis of hMLH1, CDKN2A/p16, and MGMT revealed specific methylation profiles for tubular adenomas, tubulovillous/villous adenomas, and colorectal cancers, supporting the use of these alterations in assessment of colorectal tumorigenesis.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation / physiology. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Nuclear Proteins / genetics. Promoter Regions, Genetic / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Aged. CpG Islands / genetics. Disease Progression. Female. Humans. Male. Microsatellite Repeats / genetics. Middle Aged

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  • (PMID = 20653064.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
  • [Other-IDs] NLM/ PMC2909555
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78. Lin OS, Schembre DB, McCormick SE, Gluck M, Patterson DJ, Jiranek GC, Soon MS, Kozarek RA: Risk of proximal colorectal neoplasia among asymptomatic patients with distal hyperplastic polyps. Am J Med; 2005 Oct;118(10):1113-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Our goal is to assess the risk of proximal neoplasia in asymptomatic patients with distal hyperplastic polyps, compared to those with distal tubular adenomas or no distal polyps.
  • METHODS: We assessed proximal (cecum, ascending, transverse colon and splenic flexure) and distal polyps in patients undergoing screening colonoscopy, classifying them into 3 groups: distal hyperplastic polyps only; distal adenomas with or without hyperplastic polyps; no distal polyps.
  • The prevalence of proximal neoplasia and advanced neoplasia (polyps > or =1 cm, villous adenomas, or cancer) was compared among these groups.
  • Proximal neoplasia occurred in 175 (9%) of 1896 patients with no distal polyps, compared with 28 (12%) of 237 with distal hyperplastic polyps (P = 0.20) and 64 (29%) of 224 with distal adenomas (P <0.0001).
  • Proximal advanced neoplasia occurred in 39 (2%) patients with no distal polyps, compared with 4 (2%) with distal hyperplastic polyps (P = 0.70) and 9 (4%) with distal adenomas (P = 0.13).
  • CONCLUSIONS: Patients with distal hyperplastic polyps, unlike those with distal adenomas, do not exhibit an increased risk for proximal neoplasia or proximal advanced neoplasia compared to those with no distal polyps.
  • [MeSH-major] Adenoma / epidemiology. Colon / pathology. Colorectal Neoplasms / epidemiology. Intestinal Polyps / epidemiology. Precancerous Conditions / epidemiology. Rectum / pathology

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  • (PMID = 16194642.001).
  • [ISSN] 0002-9343
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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79. Gutman F, Alberini JL, Wartski M, Vilain D, Le Stanc E, Sarandi F, Corone C, Tainturier C, Pecking AP: Incidental colonic focal lesions detected by FDG PET/CT. AJR Am J Roentgenol; 2005 Aug;185(2):495-500
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  • OBJECTIVE: The aim of this study was to assess the performance of FDG PET/CT for the detection of colonic lesions, especially advanced neoplasms (villous or >10-mm adenomas, carcinomas).
  • RESULTS: The FDG colonic foci were associated with 18 colonoscopic abnormalities in 15 patients, with no colonic abnormality detected in five patients (false-positive [FP] results).
  • Histopathologic findings revealed advanced neoplasms in 13 patients (13 villous adenomas and three carcinomas) and two cases of hyperplastic polyps.
  • CONCLUSION: Presence of a focal colonic FDG uptake incidental finding on a PET/CT scan justifies a colonoscopy to detect (pre-)malignant lesions.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / radiography. Adenoma / radionuclide imaging. Aged. Colonic Polyps / diagnosis. Colonic Polyps / radiography. Colonic Polyps / radionuclide imaging. Colonoscopy. Female. Humans. Image Processing, Computer-Assisted. Male. Middle Aged

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  • (PMID = 16037527.001).
  • [ISSN] 0361-803X
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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80. Qiu HZ, Wu B, Lin GL, Xiao Y: [Therapeutic effects of transsphincteric surgery in treating rectal tumors: a report of 97 cases]. Zhonghua Wai Ke Za Zhi; 2007 Sep 1;45(17):1167-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pathological examination showed rectal villous adenoma in 35 cases, rectal cancer in 50, rectal carcinoid and others in 12.

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  • (PMID = 18067707.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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81. Tao S, Lu Q, Jiang B: [The clinical significance of colorectal flat lesions under endoscopy]. Zhonghua Yi Xue Za Zhi; 2007 May 29;87(20):1417-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To identify flat lesion in colon and rectum with combination of magnifying endoscope and mucosa staining technique ad to compare the differences between the protruded and flat colorectal lesions.
  • (1) A total of 1472 adenoma cases were found; 154 (10.46%) of which were of the flat type. (2) The average size of flat adenoma was (17 +/- 14) mm, significantly smaller than that of polypoid adenoma [(29 +/- 9) mm, P < 0.05)]. (3) The incidence of colorectal tumor in the left colon was 82.35% (140/170) in the flat type tumor, significantly higher than that in the protruded type tumors (79.59%, 1630/2048, P = 0.013). (4) The incidence rates of tubular adenoma, tubulo-villous adenoma, villous adenoma, and cancer were 51.34%, 4.25%, 8.79%, and 35.65% respectively in the protruded type tumor, and were 55.55%, 17.06%, 17.64%, and 9.43% respectively.
  • CONCLUSION: The detection rates of moderate and severe dysplasia and early colorectal cancer in the flat adenomas are higher than in the protruded adenoma.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / epidemiology. Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / epidemiology. Adolescent. Adult. Aged. Aged, 80 and over. China / epidemiology. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Diagnosis, Differential. Humans. Incidence. Middle Aged

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  • (PMID = 17785067.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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82. Bussom S, Saif MW: Intraductal papillary mucinous neoplasia (IPMN). Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010. JOP; 2010;11(2):131-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • IPMN is a disease of the ductal epithelium and represent a spectrum of disease, ranging from benign to malignant lesions, making the early detection and characterization of these lesions important.
  • As with villous adenomas of the colon, not all IPMNs will develop into adenocarcinoma.

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  • (PMID = 20208320.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Cytokines
  • [Number-of-references] 26
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83. Mila R, Grille S, Laurini M, Lapiedra D, Bagattini JC: [McKittrick- Wheelock syndrome: report of one case]. Rev Med Chil; 2008 Jul;136(7):900-4
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  • Villous colorectal adenomas are common tumors that normally provoke scarce symptomatology.
  • Colonoscopy confirmed the presence of a villous adenoma that was excised surgically.
  • In this patient, the fluid and electrolyte hypersecretion of the rectal villous adenoma provoked a depletion syndrome with serious hydroelectrolytic alterations, acute renal failure and hypovolemic shock.
  • [MeSH-major] Adenoma, Villous / complications. Colonic Neoplasms / complications. Water-Electrolyte Imbalance / etiology

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  • (PMID = 18949168.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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84. Wu XL, Li DQ, Liu ZS, Wan XY, Wu YH, Jiang CQ, Zhang ZL, Qin QB, Qian Q: [Association of vascular endothelial growth factor 936C/T polymorphism and the susceptibility to colorectal adenoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Apr;13(4):286-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Association of vascular endothelial growth factor 936C/T polymorphism and the susceptibility to colorectal adenoma].
  • OBJECTIVE: To examine the association between polymorphism of vascular endothelial growth factor(VEGF)1498 C/T,936 C/T and colorectal adenoma genetic susceptibility.
  • METHODS: A case-control study of 224 colorectal adenomas and 200 controls was conducted and VEGF genotypes were determined based on TaqMan-probe assay.
  • RESULTS: The carriage of 936 CT and CT+TT genotypes had significantly higher risk of colorectal adenoma (CT vs. CC, OR=2.00, 95% CI: 1.23-3.25, P=0.006; CT+TT vs. CC, OR=2.04, 95% CI:1.28-3.26, P=0.003).
  • 936-T allele carriage had increased risk of colorectal adenoma (OR=1.91, 95% CI:1.25-2.91, P=0.003).
  • In patients with 936 CT+TT and 936-T allele implied a tendency of villous adenoma category (CT+TT vs. CC, OR=2.54, 95% CI:1.12-5.75, P=0.040; T allele vs. C allele, OR=3.08, 95% CI, 1.64-5.80, P=0.001).
  • CONCLUSION: VEGF 936 C/T polymorphism can influence susceptibility to colorectal adenoma.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Polymorphism, Single Nucleotide. Vascular Endothelial Growth Factor A / genetics
  • [MeSH-minor] Adult. Case-Control Studies. Female. Genetic Predisposition to Disease. Genotype. Humans. Middle Aged

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  • (PMID = 20422487.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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85. Lim M, Adsay NV, Grignon D, Osunkoya AO: Urothelial carcinoma with villoglandular differentiation: a study of 14 cases. Mod Pathol; 2009 Oct;22(10):1280-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumors with either glandular or villous features, such as villous adenomas, in situ adenocarcinomas, invasive adenocarcinomas, and variants of urothelial carcinoma such as micropapillary carcinomas have been described.
  • However, urothelial carcinomas with both villous and glandular features have not been well characterized.

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  • (PMID = 19593329.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Neneman B, Gasiorowska A, Małecka-Panas E: The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon. Adv Med Sci; 2006;51:88-93
Hazardous Substances Data Bank. Argon, Elemental .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Pathologic examination revealed 10 hyperplastic polyps and 12 tubular adenomas of the stomach.
  • Among colonic polyps there were: 17 hyperplastic, 26 tubular, 8 tubulo-villous, 4 villous adenomas and 3 inflammatory pseudopolyps.
  • A significant positive correlation between the power output and the size, distal location and villous texture of the polyp has been demonstrated.
  • In the case of colonic polyps the application of higher electric power should be recommended in case of large-sized lesions, located in rectum and of villous texture.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adult. Aged. Argon / therapeutic use. Colonoscopy. Endoscopy. Female. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 17357283.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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87. Newman RJ, Nichols DB, Cummings DM: Outpatient colonoscopy by rural family physicians. Ann Fam Med; 2005 Mar-Apr;3(2):122-5
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  • RESULTS: The adenoma detection rate was 27.2% for men and 21.4% for women older than age 50 years.
  • Six adenocarcinomas and 5 large (>2 cm) villous adenomas were detected, and the patients were referred for definitive surgical resection.

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  • [Cites] Gastroenterology. 1997 Jan;112(1):24-8 [8978338.001]
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  • (PMID = 15798037.001).
  • [ISSN] 1544-1717
  • [Journal-full-title] Annals of family medicine
  • [ISO-abbreviation] Ann Fam Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1466847
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88. Beattie GC, Paul I, Calvert CH: Endoscopic transanal resection of rectal tumours using a urological resectoscope--still has a role in selected patients. Colorectal Dis; 2005 Jan;7(1):47-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Transanal resection of rectal villous adenomas or adenocarcinomas can be carried out using various modalities such as operative excision, fulguration, laser coagulation or cryotherapy.
  • The median interval between resections for recurrent disease (excluding planned repeat resections) was 340 days (range 168-2337 days).
  • Histopathology revealed rectal adenoma (with varying degrees of dysplasia) in 11 (55%) patients and adenocarcinoma in 9 (45%).
  • The majority (30; 70%) of resections were carried out in patients with benign disease, with 13 (30%) in patients with rectal adenocarcinoma.
  • No patients with benign disease subsequently developed an invasive carcinoma.
  • CONCLUSIONS: Accepting that this technique provides limited histopathological information regarding extent of resection and tumour clearance, our experience demonstrates that ETAR of rectal tumours using the urological resectoscope can provide a minimally invasive, effective and safe means of treating and palliating patients with benign and malignant rectal disease.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Proctoscopy. Rectal Neoplasms / surgery. Urologic Surgical Procedures / instrumentation

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  • (PMID = 15606584.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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89. Ibrahim OO, Anjorin AS, Afolayan AE, Badmos KB: Pathological characterization of colorectal polyps in Ilorin, Nigeria. Afr J Med Med Sci; 2010 Sep;39(3):215-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Colorectal polyps especially the adenomas are recognized precursors of colorectal carcinoma.
  • Seventeen (38.6%) were adenomas, 9 (20.5%) were juvenile polyps, 8 (18.2%) were inflammatory polyps, 4 cases were lipomatous polyps, 3 were leiomatous polyps, and one each of lymphoid polyp, hamartomatous polyp and neurofibromatous polyp.
  • Of the adenomas, 11 (58.8%) were tubular, 5 (29.4%) were villous, 1 (5.9%) was tubulovillous, and one was a villous adenoma with a focus of malignant transformation.

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  • (PMID = 21416791.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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90. Selcuk H, Korkmaz M, Kanbay M, Tore E, Sumer H, Unal H, Yeloglu O, Gur G, Bilezikci B, Demirhan B, Yilmaz U, Boyacioglu S: Total colonic polyp diameter: a marker for the risk of malignancy? Hepatogastroenterology; 2008 May-Jun;55(84):936-9
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  • The polyps were further categorized by histopathologic component as "unfavorable" or "favorable" and were divided into 2 groups: group 1 (those identified as carci noma, carcinoma in situ, villous adenoma, and tubulovillous adenoma with a villous component of more than 25%) and group 2 (mixed adenomatous polyps with various degrees of hyperplastic or inflammatory components and adenomas with a tubular component of more than 75%).
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Adenomatous Polyps / pathology. Adult. Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Colonoscopy. Female. Humans. Male. Middle Aged. Prognosis. Risk Factors

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  • (PMID = 18705301.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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91. Avanesian AA, Shcherbakov AM: [An experience with clinical endoscopy and argon-plasma coagulation for removal of large bowel polyps]. Vopr Onkol; 2005;51(5):592-4
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  • Polyp diameter ranged 1.0-1.9 cm (12 adenomas), 2-2.9 (18) or 3-5 cm (21).
  • Complete destruction of adenomas was achieved by 1-6 coagulations (mean - 1.4) performed at an interval of 3-4 weeks.
  • During follow-up (6-24 months), out of 40 patients with 51 polyps, histologically identifiable villous adenoma was detected in 3 (during 12 months).

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  • (PMID = 16756019.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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92. Ghidirim G, Mişin I, Istrate V, Cazacu S: Endoscopic papillectomy into the treatment of neoplastic lesions of vater papilla. Curr Health Sci J; 2009 Apr;35(2):92-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomas of the duodenal papilla are rare.
  • The frequency of malignant adenomas is 15-30%.
  • Villous adenoma is a premalignant lesion with the highest rate of transformation.
  • AIM: Evaluation of the efficacy and safety of endoscopic papillectomy for ampullary adenomas.
  • MATERIAL AND METHOD: 12 patients were selected (F:M, 5:7, age range 37 - 68 years) with ampullary adenoma, treated by endoscopic papillectomy.
  • Pathology examination has show: tubulo-villous adenoma (5 patients); villous adenoma (4 patients), tubular adenoma (2 cases), adenocarcinoma (one case).
  • CONCLUSION: Endoscopic papillectomy is a safe and well-tolerated alternative to surgical treatment of ampullary adenoma.

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  • (PMID = 24778815.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945241
  • [Keywords] NOTNLM ; Vater papilla / ampullary adenoma / bleeding / endoscopic papillectomy / pancreatitis / sphyncterotomy
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93. Zhou ZY, Han Y, Wang LP: [A study on microsatellite instability status for colorectal serrated lesions]. Zhonghua Nei Ke Za Zhi; 2009 May;48(5):402-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To verify the traditional serrated pathway by comparing microsatellite instability (MSI) status among traditional serrated adenoma, traditional adenoma, serrated colorectal cancer and non-serrated colorectal cancer.
  • METHODS: Seventy-five paraffin-embedded tissue samples, including 15 with serrated adenocarcinoma (Sca), 20 with non-serrated adenocarcinoma (N-Sca), 20 with traditional serrated adenoma (TSA) and 20 with villous adenoma (AD) were collected from the pathology department of our hospital.
  • RESULTS: Six of 18 samples with TSA harbored MSI-H and twelve MSI-L/MSS; 18 samples with conventional adenoma were exclusively of MSS; 3 of 13 samples of serrated carcinoma harbored MSI-H and ten MSI-L/MSS; 18 of 19 N-Sca samples harbored MSI-L/MSS and only one MSI-H.
  • With Chi-square test, the MSI frequency in AD group and N-Sca group was significantly lower than that in TSA group and Sca group (P<0.05); but with no statistical difference between the TSA group and Sca groups (P>0.05).
  • CONCLUSION: MSI-H frequency in AD group and N-Sca group was obviously lower than that of TSA group and Sca group.
  • It is concluded that there might be a new traditional serrated neoplasia pathway which is different from the conventional adenoma-carcinoma carcinogenesis pathway, but we still need prospective follow-up studies to verify its existence.
  • [MeSH-major] Adenoma, Villous / genetics. Colorectal Neoplasms / genetics. Microsatellite Instability

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  • (PMID = 19615160.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
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94. Odom SR, Duffy SD, Barone JE, Ghevariya V, McClane SJ: The rate of adenocarcinoma in endoscopically removed colorectal polyps. Am Surg; 2005 Dec;71(12):1024-6
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  • A total of 4,443 polyps were found, of which 3,225 were adenomatous [2,883 (89.4%) tubular adenomas, 399 (9.3%) tubulo-villous adenomas, 32 (1.0%) villous adenomas, and 11 (0.3%) carcinomas].

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  • (PMID = 16447472.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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95. Rennert G, Almog R, Tomsho LP, Low M, Pinchev M, Chaiter Y, Bonner JD, Rennert HS, Greenson JK, Gruber SB: Colorectal polyps in carriers of the APC I1307K polymorphism. Dis Colon Rectum; 2005 Dec;48(12):2317-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared.
  • Adenomas with a tubular component (either tubular adenomas or tubulovillous adenomas), but not villous adenomas, were significantly more frequent among carriers (37.2 percent vs. 23.6 percent, P = 0.005).
  • CONCLUSION: Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
  • [MeSH-major] Adenoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. Genes, APC. Polymorphism, Genetic

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  • (PMID = 16228836.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Platell C, Salama P, Barwood N, Makin G: Performing a colonoscopy 12 months after surgery for colorectal neoplasia. ANZ J Surg; 2005 May;75(5):282-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • On histology, 42% were tubular adenomas, 6% tubulo-villous adenomas, 7% were villous adenomas, and 37% were hyperplastic.
  • Advanced adenomas were identified in 7.9% of patients (95% CI 4.8-12.1%).
  • CONCLUSION: We have observed a high prevalence of advanced adenomas in patients undergoing a 12-month, follow-up colonoscopy after curative surgery for colorectal neoplasia.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Second Primary / diagnosis

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  • [CommentIn] ANZ J Surg. 2005 May;75(5):257-8 [15932431.001]
  • (PMID = 15932437.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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97. Yoo TW, Park DI, Kim YH, Kim HS, Kim WH, Kim TI, Kim HJ, Yang SK, Byeon JS, Lee MS, Jung IK, Chung MK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS, Song JS: Clinical significance of small colorectal adenoma less than 10 mm: the KASID study. Hepatogastroenterology; 2007 Mar;54(74):418-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical significance of small colorectal adenoma less than 10 mm: the KASID study.
  • BACKGROUND/AIMS: Polypectomy is the current modality of choice to prevent benign colorectal adenoma from progressing to an invasive cancer.
  • However, in cases of small colorectal adenoma, it remains unclear as to whether polypectomy is actually an effective treatment modality.
  • We evaluated the clinical significance of polypectomy in cases of small colorectal adenomas, measuring less than 10 mm.
  • A total of 5996 colorectal adenomas were detected and divided into 5 groups according to their size (Group 1; 1-5 mm, Group 2; 6-7 mm, Group 3; 8-9 mm, Group 4; 10-19 mm, Group 5; more than 20 mm).
  • The term 'advanced adenoma' refers here to tubular adenomas with diameters of at least 10 mm, or to tubulovillous, villous, or high-grade dysplasia, irrespective of size.
  • RESULTS: As the sizes of the adenomas increased, the prevalence of advanced adenoma was also observed to increase.
  • In Groups 2 and 3, the prevalence of tubulovillous or villous adenoma were higher than was expected (5.2% and 6.6%, p < 0.001).
  • CONCLUSIONS: In cases of small colorectal adenomas, measuring between 6 and 9 mm, the prevalence of cancer was at least as high as that seen in the cases of colorectal adenomas measuring between 10 and 19 mm.
  • Therefore, small colorectal adenomas measuring between 6 and 9 mm should not be ignored, in order to decrease the prevalence of colorectal cancer.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / pathology. Adenoma, Villous / surgery. Adult. Aged. Cell Transformation, Neoplastic / pathology. Cohort Studies. Colonoscopy. Female. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Male. Middle Aged. Risk Factors

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  • (PMID = 17523287.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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98. Zhongyin Z, Hesheng L, Jun L, Jihong C: Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas. Saudi Med J; 2006 Feb;27(2):161-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas.
  • OBJECTIVE: To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas.
  • Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined.
  • RESULTS: Serum TC levels of colorectal adenomas group (5.32 +/- 0.85 mmol/L), distal colorectal adenomas group (5.58 +/- 0.63 mmol/L), and villous adenoma group (5.49 +/- 0.69 mmol/L) were higher than the control group (4.28 +/- 0.62 mmol/L, p=0.016), proximal colorectal adenomas group (4.82 +/- 0.58 mmol/L, p=0.038) and non-villous adenoma group (4.76 +/- 0.58 mmol/L, p=0.03).
  • Serum HDL-C levels of colorectal adenomas group (1.39 +/- 0.25 mmol/L) were lower than the control group (1.51 +/- 0.29 mmol/L) (p=0.035).
  • Serum lipids levels of each genotype in colorectal adenomas group were not statistically significant.
  • Apolipoprotein E3/E4 genotypic frequency in colorectal adenomas group (7.1%) was lower than the control group (17.5%) (p=0.012).
  • CONCLUSION: The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE E3/E4 genotype have lower risk suffering from colorectal adenomas than those with other genotypes.
  • [MeSH-major] Adenoma / blood. Adenoma / genetics. Apolipoproteins E / genetics. Colorectal Neoplasms / blood. Colorectal Neoplasms / genetics. Lipids / blood

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  • Hazardous Substances Data Bank. CHOLESTEROL .
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  • (PMID = 16501668.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Cholesterol, HDL; 0 / Cholesterol, LDL; 0 / Lipids; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
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99. Ah Soune P, Ménard C, Salah E, Desjeux A, Grimaud JC, Barthet M: Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm. World J Gastroenterol; 2010 Feb 7;16(5):588-95
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  • Pathological examination showed tubulous adenoma in 31%, tubulo-villous adenoma in 27%, villous adenoma in 42%, high-grade dysplasia in 38%, in situ carcinoma in 19% of the cases and mucosal carcinoma (m2) in 8% of the cases.

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  • (PMID = 20128027.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2816271
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100. Tsuchida K, Morinaga S, Sugano N, Shiozawa M, Akaike M, Sugimasa Y, Takemiya S, Hayashi H, Rino Y, Imada T: [A case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1878-80
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  • [Title] [A case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer].
  • Duodenal adenoma is rare, and there have been very few case reports of flat elevated type adenoma.
  • We report a case of flat elevated type carcinoma in adenoma of the duodenum with gastric cancer.
  • The biopsy specimen of the duodenal lesion was diagnosed as adenoma.
  • Histologically, the gastric cancer was poorly differentiated adenocarcinoma with submcosal invasion and without lymph node metastasis, and the duodenal tumor was a well differentiated carcinoma in villous adenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Carcinoma / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology

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  • (PMID = 17212134.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 4
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