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1. Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S: Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. BMC Cancer; 2008 Jan 29;8:33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma.
  • METHODS: By immunohistochemistry, we assessed COX-2 expression in 24 hyperplastic polyps, 7 sessile serrated polyp/adenomas (SSA), 5 mixed polyps with SSA and adenoma, 27 traditional serrated adenomas, 515 non-serrated adenomas (tubular adenoma, tubulovillous adenoma and villous adenoma), 33 adenomas with intramucosal carcinomas, 96 adenocarcinomas with serration (corkscrew gland) and 111 adenocarcinomas without serration.
  • RESULTS: Strong (2+) COX-2 overexpression was more common in non-serrated adenomas (28% = 143/515) than in hyperplastic polyps (4.2% = 1/24, p = 0.008) and serrated polyps (7 SSAs and 5 mixed polyps) (0% = 0/12, p = 0.04).
  • Furthermore, any (1+/2+) COX-2 overexpression was more frequent in non-serrated adenomas (60% = 307/515) than in hyperplastic polyps (13% = 3/24, p < 0.0001) and serrated polyps (SSAs and mixed polyps) (25% = 3/12, p = 0.03).
  • Traditional serrated adenomas and non-serrated adenomas showed similar frequencies of COX-2 overexpression.
  • Tumor location was not significantly correlated with COX-2 overexpression, although there was a trend towards higher frequencies of COX-2 overexpression in distal tumors (than proximal tumors) among hyperplastic polyps, SSAs, mixed polyps, traditional serrated adenomas and adenocarcinomas.
  • CONCLUSION: COX-2 overexpression is infrequent in hyperplastic polyp, SSA and mixed polyp with SSA and adenoma, compared to non-serrated and serrated adenoma.

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  • (PMID = 18230181.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA087969; United States / NCI NIH HHS / CA / P01 CA055075; United States / NCI NIH HHS / CA / K07 CA122826; United States / NCI NIH HHS / CA / P01 CA87969; United States / NCI NIH HHS / CA / P01 CA55075; United States / NCI NIH HHS / CA / P50 CA127003
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  • [Other-IDs] NLM/ PMC2257954
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2. Kim JH, Choi JW, Seo YS, Lee BJ, Yeon JE, Kim JS, Byun KS, Bak YT, Kim I, Park JJ: Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum. World J Gastroenterol; 2007 Jun 21;13(23):3262-4
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  • [Title] Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum.
  • Moreover, duodenal tubulovillous adenomas are more uncommon lesions.
  • The microscopic structure of tubulovillous adenoma has frond-like projection of mucosa with branching papillary structure and generally upward growth into the lumen.
  • We describe a 72-year-old man who showed aduodenal tubulovillous adenoma with unusual inverted cystic growth pattern.
  • Interestingly, this tubulovillous adenomatous lesion was interrupted by gastric metaplasia in the deep portion of the cyst and was closely surrounded by Brunner's glands.
  • Therefore, these findings argued that this adenoma arises from Brunner's glands through gastric metaplasia.
  • This is the first case of inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum with gastric metaplasia.
  • [MeSH-major] Adenoma / pathology. Brunner Glands / pathology. Cysts / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 17589910.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436617
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3. Kim BS, Joo SH, Joo KR: Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report. World J Gastroenterol; 2008 Aug 7;14(29):4705-8

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  • [Title] Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report.
  • Tubulovillous adenomas are common in the colon and rectum, but are rare in the common bile duct.
  • Biliary adenomas may produce obstructive jaundice, which can be easily confused with a malignant neoplasm or stone.
  • We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice.
  • The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct.
  • The polyps were removed by endoscopic mucosal resection and shown to be tubular adenomas with high grade dysplasia.
  • Biliary adenomas require careful follow-up for early detection of recurrence and malignant transformation.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 18698689.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738799
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4. Raman JD, Gopalan A, Russo P: Tubulovillous adenoma in an Indiana pouch urinary diversion managed by endoscopic resection. Int J Urol; 2007 Sep;14(9):865-6
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  • [Title] Tubulovillous adenoma in an Indiana pouch urinary diversion managed by endoscopic resection.
  • We present a case of a tubulovillous adenoma in an Indiana pouch managed by endoscopic resection.
  • The evaluation revealed a 2.5 cm tubulovillous adenoma with high-grade dysplasia within the Indiana pouch.
  • [MeSH-major] Adenoma, Villous / surgery. Endoscopy. Urinary Reservoirs, Continent / pathology

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  • (PMID = 17760759.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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5. Yamada Y, Fujimura T, Takahashi S, Takeuchi T, Takazawa Y, Kitamura T: Tubulovillous adenoma developing after urinary reconstruction using ileal segments. Int J Urol; 2006 Aug;13(8):1134-5
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  • [Title] Tubulovillous adenoma developing after urinary reconstruction using ileal segments.
  • A case of tubulovillous adenoma arising in an augmented bladder is described.
  • Cystoscopy revealed a non-papillary multiple tumor at the site of ileovesical anastomosis and transurethral resection biopsy was performed.
  • Histopathological examination revealed a tubulovillous adenoma.
  • A tubulovillous adenoma developing at the augmented bladder is rare.
  • To our knowledge, this is the second case in which a tubulovillous adenoma developed in an augmented bladder.
  • [MeSH-major] Adenoma, Villous / etiology. Urinary Bladder / surgery. Urinary Bladder Neoplasms / etiology. Urinary Reservoirs, Continent

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  • (PMID = 16903947.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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6. Lai HC, Chan CY, Peng CY, Chen CB, Huang WH: Pyogenic liver abscess associated with large colonic tubulovillous adenoma. World J Gastroenterol; 2006 Feb 14;12(6):990-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pyogenic liver abscess associated with large colonic tubulovillous adenoma.
  • Rarely, liver abscess has been reported as the presenting manifestation of colonic tubulovillous adenoma.
  • Colonoscopy revealed large polypoid tumors with pathological findings of tubulovillous adenoma in both cases.
  • [MeSH-major] Adenoma / pathology. Adenoma / radiography. Colonic Neoplasms / pathology. Colonic Neoplasms / radiography. Liver Abscess, Pyogenic / pathology. Liver Abscess, Pyogenic / radiography

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  • (PMID = 16521236.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4066173
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7. Lee JK, Ghosh P, McWhorter V, Payne M, Olson R, Krinsky ML, Ramamoorthy S, Carethers JM: Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma. World J Gastroenterol; 2008 Jul 21;14(27):4389-94
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  • [Title] Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma.
  • Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia.
  • The surgically-excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adenocarcinoma.
  • To the best of our knowledge, this is the first report of co-existence of sarcomatoid carcinoma and invasive adenocarcinoma with tubulovillous adenoma; all stages represented within the same tumor.
  • This observation supports the "monoclonal theory" of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Colorectal Neoplasms / pathology. Sarcoma / pathology

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  • (PMID = 18666331.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2731194
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8. Tjalma WA, Colpaert CG: Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma. Int J Gynecol Cancer; 2006 May-Jun;16(3):1461-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma.
  • Biopsy revealed an adenocarcinoma of the intestinal type, with a small remnant of a villous adenoma.
  • This led to the conclusion that the lesion was a primary intestinal-type adenocarcinoma of the vagina that had arisen from a vaginal villous adenoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Villous / diagnosis. Vaginal Neoplasms / diagnosis

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  • (PMID = 16803550.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Kwon HJ, Kim JH, Bae JM, Cho NY, Kim TY, Kang GH: DNA methylation changes in ex-adenoma carcinoma of the large intestine. Virchows Arch; 2010 Oct;457(4):433-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA methylation changes in ex-adenoma carcinoma of the large intestine.
  • Ex-adenoma carcinoma (EAC) is a carcinoma with contiguous adenoma element in its vicinity which provides a morphological evidence for adenoma-carcinoma sequence.
  • Twenty-two cases of cancers had contiguous tubulovillous adenomas and 17 cases had contiguous tubular adenomas.
  • Regardless of CIMP markers or nonrelated markers, a significant increase in the number of methylated genes was found from normal mucosa to adenoma, whereas no increase was found from adenoma to carcinoma.
  • Both ALU and LINE-1 showed a significant decrease of methylation levels from normal mucosa to adenoma (p < 0.05), but there is no difference between adenoma and cancer.
  • However, SAT2 methylation level exhibited a stepwise decrease from normal mucosa to adenoma to cancer.
  • Our findings suggest that morphological progression from traditional adenoma to carcinoma does not appear to be accompanied by increases in promoter CpG island hypermethylation or repetitive DNA hypomethylation, except for SAT2 hypomethylation which showed continuous progression during multistep carcinogenesis.
  • [MeSH-major] Adenoma / genetics. Carcinoma / genetics. Colorectal Neoplasms / genetics. CpG Islands. DNA Methylation

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  • (PMID = 20711609.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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10. Neogi P, Misra A, Agrawal R: Duodenal adenoma presenting as duodenojejunal intussusception. Acta Biomed; 2008 Aug;79(2):137-9
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  • [Title] Duodenal adenoma presenting as duodenojejunal intussusception.
  • However during laparotomy, duodenojejunal intussusception was found along with an adenoma in the third part of the duodenum associated with a lax ligament of Treitz.
  • The intussusception was reduced and the parts of the duodenum containing the adenoma were resected, followed by an end-to-end duodenojejunal anastomosis.
  • To the best of our knowledge, this is the first reported case of tubulovillous adenoma in the third part of the duodenum presenting as intussusception in an adult.
  • [MeSH-major] Adenoma / pathology. Duodenal Diseases / diagnosis. Duodenal Neoplasms / pathology. Intussusception / diagnosis. Jejunal Diseases / diagnosis

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  • (PMID = 18788510.001).
  • [ISSN] 0392-4203
  • [Journal-full-title] Acta bio-medica : Atenei Parmensis
  • [ISO-abbreviation] Acta Biomed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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11. Akaydin M, Ersoy YE, Erozgen F, Ferlengez E, Kaplan R, Celik A, Memmi N: Tubulovillous adenoma in the common bile duct causing obstructive jaundice. Acta Gastroenterol Belg; 2009 Oct-Dec;72(4):450-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubulovillous adenoma in the common bile duct causing obstructive jaundice.
  • Villous adenomas are benign epithelial lesions with a malignant potential which can occur at any site in the gastrointestinal tract, usually in the rectum and colon, less frequently in the small bowel and very rarely in the biliary tract.
  • Villous adenomas of the extrahepatic bile ducts are exceptional and only a few cases have been reported.
  • Common bile duct (CBD) adenomas often present in a fashion similar to their malignant counterparts, and adenocarcinoma arising from a villous adenoma of the ampullary biliary epithelium is also extremely rare.
  • We present here a tubulovillous adenoma, arising in the common bile duct, as a cause of obstructive jaundice, and discuss the characteristics of these lesions.
  • [MeSH-major] Adenoma, Villous / complications. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology

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  • (PMID = 20163042.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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12. Ricchetti T, Paci M, Cavazza A, Ferrari G, Annessi V, De Franco S, Sgarbi G: A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma. Tumori; 2005 Mar-Apr;91(2):210-2

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  • [Title] A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma.
  • We report a case of epithelioid angiosarcoma with multiple bilateral lung infiltration, bone metastasis, and metastasis of the lamina propria of a tubulovillous adenoma of the colon.
  • [MeSH-major] Adenoma / pathology. Basement Membrane / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secretion. Sigmoid Neoplasms / pathology

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  • (PMID = 15948556.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, CD31
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13. Osifo OD, Akhiwu W, Efobi CA: Small intestinal tubulovillous adenoma--case report and literature review. Niger J Clin Pract; 2009 Jun;12(2):205-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small intestinal tubulovillous adenoma--case report and literature review.
  • We report a case of sessile and extensive tubulovillous adenoma in a 13-year-old girl.
  • Histology report was that of benign tubulovillous adenoma and the girl has enjoyed stable health for more than a year on close follow up in surgical outpatient clinic.
  • This case highlights the unusual presentation and unusual gross nature of this small intestinal adenoma, which was found to be a benign adenoma on histological examination.
  • [MeSH-major] Adenoma, Villous / diagnosis. Intestinal Neoplasms / diagnosis

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  • (PMID = 19764676.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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14. Bodin R, Peycru T, Schwartz A, Jarry J, Pommier N, Durand-Dastes F: Tubulovillous adenoma of the appendix: a case report and review of the literature. Gastroenterol Clin Biol; 2010 Nov;34(11):633-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubulovillous adenoma of the appendix: a case report and review of the literature.
  • The histological examination of the resected specimen revealed a rare tumor: tubulovillous adenoma, discovered in 0.02% of all appendectomy procedures.
  • [MeSH-major] Adenoma, Villous / surgery. Appendectomy. Appendiceal Neoplasms / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20739133.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] France
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15. Kondo T: Colon invasive micropapillary carcinoma arising in tubulovillous adenoma. Pol J Pathol; 2008;59(3):183-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colon invasive micropapillary carcinoma arising in tubulovillous adenoma.
  • [MeSH-major] Adenoma, Villous / pathology. Carcinoma, Papillary / pathology. Colonic Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19097358.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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16. Kuratate S, Inoue S, Chikakiyo M, Kaneda Y, Harino Y, Hirose T, Yagi T, Saitoh S, Sumitomo M, Fujino R, Satake N: Coexistent poorly-differentiated neuroendocrine cell carcinoma and non-invasive well-differentiated adenocarcinoma in tubulovillous adenoma of the rectum: report of a case. J Med Invest; 2010 Aug;57(3-4):338-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistent poorly-differentiated neuroendocrine cell carcinoma and non-invasive well-differentiated adenocarcinoma in tubulovillous adenoma of the rectum: report of a case.
  • Colonoscopy revealed villous tumor covering all the lower rectal lumen.
  • Biopsy yielded a diagnosis of adenoma.
  • Histological and immuno- histochemical features showed coexistent poorly-differentiated small cell neuroendocrine cell (NEC) carcinoma and non-invasive well-differentiated adenocarcinoma in tubulovillous adenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Carcinoma, Neuroendocrine / pathology. Neoplasms, Multiple Primary / pathology. Rectal Neoplasms / pathology

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  • (PMID = 20847536.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Tamiolakis D, Venizelos I: Inverse correlation between HLA-DR antigen expression and CD4 positive lymphocytic populations in normal mucosa, tubulovillous adenoma, and invasive carcinoma of the colon. Cesk Patol; 2006 Apr;42(2):52-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inverse correlation between HLA-DR antigen expression and CD4 positive lymphocytic populations in normal mucosa, tubulovillous adenoma, and invasive carcinoma of the colon.
  • In this study we used immunohistochemistry to analyse the expression of HLA-DR on epithelial cells of normal colonic mucosa, tubulovillous adenoma, and invasive carcinoma, as well as the magnitude of the stromal T lymphocytes at the relevant sites.
  • Yet, we investigated the association of HLA-DR plus DQ genes and adenoma or carcinoma by PCR.
  • MATERIALS AND METHODS: 31 cases of normal colonic mucosa, 12 cases of tubulovillous adenoma, and 39 cases of invasive carcinoma were surveyed for the detection of HLA-DR monoclonal antigen, and the T helper (TH) marker (CD4) in the stroma (lamina propria) of the relevant cases.
  • RESULTS: HLA-DR was expressed in 20 of 31 normal colonic mucosas (64.5%), 4 of 12 adenomas (33.3%), and in 10 of 39 invasive carcinomas (25.6%).
  • No significant correlation between HLA-DR plus DQ genes and adenoma or cancer of the colon was found.
  • CD4 positive cells were found in 9 of 31 normal colonic mucosas (29%), 5 of 12 adenomas (42%), and in 26 of 39 invasive carcinomas (67%).
  • HLA-DR and DQ genes do not contribute to a susceptibility to adenoma or carcinoma.
  • [MeSH-major] Adenoma, Villous / immunology. CD4-Positive T-Lymphocytes / pathology. Carcinoma / immunology. Colonic Neoplasms / immunology. HLA-DR Antigens / analysis. Intestinal Mucosa / immunology

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  • [CommentIn] Ann Saudi Med. 2009 Nov-Dec;29(6):489 [20232495.001]
  • (PMID = 16715627.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Duplicate Publication; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / HLA-DR Antigens
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18. Guan J, Chen J, Luo YF, Cao JL, Zhao H, Hao J: [Expression of survivin in colorectal adenoma and adenocarcinoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2007 Jun;29(3):398-401
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  • [Title] [Expression of survivin in colorectal adenoma and adenocarcinoma].
  • METHODS Immunohistochemistry staining was performed by two-step EnVision technique for the paraffin sections, which included 90 adenomas, 25 ademomas with high-grade glandular intraepithelial neoplasia, and 108 colorectal adenocarcinomas.
  • The positive rate of SVV in tubular adenomas, villous adenomas, and tubulovillous adenomas were 30% (12/40), 40.9% (9/22), and 35.8% (10/28), respectively.
  • The positive rate of SVV in tubulovillous adenomas with high-grade glandular intraepithelial neoplasia were 68% (17/25).
  • SVV expressions among the three types of adenomas without neoplasia were not significantly different (P > 0.05).
  • SVV expression between each type of the above-mentioned ademoma and tubulovillous adenoma with high-grade glandular intraepithelial neoplasia or different Dukes stages of colorectal carcinoma was significantly different (P < 0.05).
  • SVV expressions in adenocarcinomas and adenomas with high grade glandular intraepithelial neoplasia were significantly higher than those in adenomas (P < 0.01).
  • SVV expression may be useful to distinguish adenocarcinoma from adenoma in colorectal carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Microtubule-Associated Proteins / biosynthesis

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  • (PMID = 17633470.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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19. Anand BS, Verstovsek G, Cole G: Tubulovillous adenoma of anal canal: a case report. World J Gastroenterol; 2006 Mar 21;12(11):1780-1
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  • [Title] Tubulovillous adenoma of anal canal: a case report.
  • We present a case of benign anal adenomas arising from the anus, an extremely rare diagnosis.
  • Microscopic examination revealed a tubulovillus adenoma with no areas of high grade dysplasia or malignant transformation.
  • We believe the tubulovillus adenoma arose from either an anal gland or its duct that opens into the anus.
  • [MeSH-major] Adenoma, Villous / diagnosis. Anus Neoplasms / diagnosis

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  • [Cites] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597.001]
  • [Cites] J Clin Pathol. 2005 Feb;58(2):217-9 [15677547.001]
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  • (PMID = 16586552.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4124358
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20. Greco S, Cassinotti A, Massari A, Bossi I, Trabucchi E, Bianchi Porro G: Isolated ampullary adenoma causing biliary obstruction. J Gastrointestin Liver Dis; 2008 Sep;17(3):329-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated ampullary adenoma causing biliary obstruction.
  • This is an interesting case of an isolated ampullary adenoma causing biliary obstruction that required surgical excision.
  • We describe a patient who presented with a six month history of recurrent attacks of typical biliary pain radiating from the right upper quadrant of the abdomen to the back, nausea and vomiting, which we attributed to a large pedunculated tubulovillous adenoma.
  • Abdominal ultrasound and endoscopic ultrasonography provided useful information in the diagnostic assessment of ampullary adenoma.
  • Sporadic duodenal adenomas are an increasingly recognized condition in those with familial adenomatous polyposis syndromes as well as sporadic cases.
  • [MeSH-major] Adenoma / complications. Ampulla of Vater. Cholestasis / etiology. Common Bile Duct Neoplasms / complications

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  • (PMID = 18836629.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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21. Kaklamanis L, Trichas M, Amarantidis K, Spathari N, Micheli A, Karayiannakis A, Chatzaki E, Georgoulias V, Kakolyris S: VEGF expression in the colorectal adenoma-carcinoma sequence. Oncol Res; 2006;15(9):445-51
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  • [Title] VEGF expression in the colorectal adenoma-carcinoma sequence.
  • VEGF and p53 expression were evaluated in 16 hyperplastic polyps, 35 solitary tubular and tubulovillous adenomas, and 47 cases of sporadic colorectal carcinomas arising on the basis of preexisting adenomas, using immunohistochemistry.
  • Carcinomas arising from VEGF-positive adenomas were mostly VEGF positive (10/11, 91%), whereas in 28/36 (78%) carcinomas arising from VEGF-negative adenomas VEGF expression was not detected.
  • We conclude that VEGF associates with angiogenesis in colorectal cancer, and its pattern of expression in adenomas is maintained in the arising carcinomas.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Colorectal Neoplasms / metabolism. Gene Expression. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 16555551.001).
  • [ISSN] 0965-0407
  • [Journal-full-title] Oncology research
  • [ISO-abbreviation] Oncol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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22. Hemandas AK, Robson NK, Hickish T, Talbot RW: Colorectal tubulovillous adenomas identified on fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography scans. Colorectal Dis; 2008 May;10(4):386-9
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  • [Title] Colorectal tubulovillous adenomas identified on fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography scans.
  • [MeSH-major] Adenoma, Villous / diagnosis. Adenomatous Polyps / radionuclide imaging. Colorectal Neoplasms / radionuclide imaging. Incidental Findings. Positron-Emission Tomography

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  • (PMID = 17608754.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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23. Pantanowitz L: Colonic adenoma with squamous metaplasia. Int J Surg Pathol; 2009 Aug;17(4):340-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic adenoma with squamous metaplasia.
  • Squamous metaplasia arising within colon adenomas is a rare occurrence, with a 0.4% incidence noted predominantly in elderly males.
  • A case of squamous metaplasia arising in a tubulovillous adenoma of the cecum, associated with adenocarcinoma, is described.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology

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  • (PMID = 18701516.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / beta Catenin
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24. Kakar S, Deng G, Cun L, Sahai V, Kim YS: CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. Hum Pathol; 2008 Jan;39(1):30-6
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  • [Title] CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.
  • We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS mutations and methylation at hMLH1, p16, HIC1, RASSF2, MGMT, MINT1, and MINT31.
  • CIMP-positive status (methylation at 3 or more loci) was observed in 44% tubulovillous/villous adenomas compared with 8 (27%) of 30 tubular adenomas (P = .08).
  • Tubulovillous/villous adenomas showed significantly higher methylation than tubular adenomas at MGMT (87% vs 37%, P < .01) and RASSF2 (94% vs 70%, P = .02).
  • There was no significant difference in methylation of HIC1, MINT1, MINT31, and p16. hMLH1 methylation was absent in all tubulovillous/villous adenomas and seen in only 2 (7%) tubular adenomas.
  • CIMP-positive status correlated with large size, right-sided location, and amount of villous component in tubulovillous/villous adenomas.
  • BRAF V600E mutation was not observed in any tubular adenoma or tubulovillous/villous adenoma.
  • KRAS mutations were seen in 9% of tubulovillous/villous adenomas and 10% of tubular adenomas.
  • In conclusion, CIMP-positive phenotype is common in tubulovillous/villous adenomas and increases with large size, right-sided location, and amount of villous component.
  • Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma.
  • BRAF mutations are absent in tubulovillous/villous adenomas.
  • [MeSH-major] Adenoma, Villous / genetics. Adenoma, Villous / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. CpG Islands. DNA Methylation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. ras Proteins / genetics

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  • (PMID = 17950780.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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25. Nosho K, Yamamoto H, Takamaru H, Hamamoto Y, Goto A, Yoshida Y, Arimura Y, Endo T, Hirata K, Imai K: A case of colorectal carcinoma in adenoma analyzed by a cDNA array. Int J Colorectal Dis; 2005 May;20(3):287-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of colorectal carcinoma in adenoma analyzed by a cDNA array.
  • Microscopically, the large tumor consisted of a well-differentiated adenocarcinoma with a tubulovillous adenoma (TVA) component (carcinoma in adenoma).
  • K-ras mutation was detected in both CA and TVA lesions of the carcinoma in adenoma.
  • To clarify relevant alterations of gene expression associated with adenoma-carcinoma progression, the gene expression profiles of these tumor tissues were analyzed by a cDNA array.
  • The results were further substantiated by comparison of the gene expression profiles of CA and TVA lesions of the carcinoma in adenoma.
  • CONCLUSION: The results suggest that overexpression of IGF-II played an important role in the progression of adenoma to carcinoma in this patient.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma, Villous / genetics. Colorectal Neoplasms / genetics. DNA, Complementary / analysis. Neoplasms, Multiple Primary

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  • (PMID = 15490195.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Complementary; 0 / RNA, Messenger; 67763-97-7 / Insulin-Like Growth Factor II
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26. Armah HB, Krasinskas AM, Parwani AV: Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case. Diagn Pathol; 2007;2:29

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case.
  • We present the case of a 39-year-old male with a tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty to enlarge a post-chemoradiation-induced shrunken bladder.
  • Cystoscopy revealed a papillary tumor at the site of ileovesical anastomosis, and transurethral resection was performed.
  • Histologic examination revealed a tubular adenoma with high-grade dysplasia.
  • There are only two previous reports of tubulovillous adenoma in ileal segment after ileocystoplasty, both without high-grade dysplasia.
  • Our observation supports the hypothesis that an ileal neobladder may undergo all the morphologic and molecular changes observed in the development of gastrointestinal adenocarcinoma.

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  • (PMID = 17697327.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1995190
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27. Lee SE, Park NH, Park IA, Kang SB, Lee HP: Tubulo-villous adenoma of the vagina. Gynecol Oncol; 2005 Feb;96(2):556-8
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  • [Title] Tubulo-villous adenoma of the vagina.
  • BACKGROUND: Tubulo-villous adenomas are common in the colon and rectum, but extremely rare in the vagina.
  • As far as we know, only two cases of tubulo-villous adenoma have ever been reported.
  • We report the third case of enteric-type tubulo-villous adenoma of the vagina.
  • The tumor was excised and pathologically confirmed as a tubulo-villous adenoma.
  • CONCLUSION: Because some tubulo-villous adenomas in the colon and rectum can progress to the cancer, this case requires long-term follow-up to detect recurrence and malignant transformation.
  • [MeSH-major] Adenoma, Villous / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 15661252.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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28. Kahveci A, Ari E, Arikan H, Koc M, Tuglular S, Ozener C: Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient. Hemodial Int; 2010 Jan;14(1):91-3
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  • [Title] Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient.
  • Abstract We report the case of a 54-year-old hemodialysis patient who presented with recurrent fever due to Streptococcus bovis bacteremia related to colonic tubulovillous adenoma.
  • In this paper, we discussed the relation between S. bovis bacteremia, colonic adenomas, and hemodialysis.
  • [MeSH-major] Adenoma / microbiology. Bacteremia / etiology. Colonic Neoplasms / microbiology. Kidney Failure, Chronic / therapy. Renal Dialysis / adverse effects. Streptococcal Infections / pathology. Streptococcus bovis / isolation & purification

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  • (PMID = 19758303.001).
  • [ISSN] 1542-4758
  • [Journal-full-title] Hemodialysis international. International Symposium on Home Hemodialysis
  • [ISO-abbreviation] Hemodial Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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29. Chang HY, Changchien CC, Chen HH, Lin H, Huang CC: Extrauterine müllerian adenosarcoma associated with endometriosis and rectal villotubular adenoma: report of a case and review of the literature. Int J Gynecol Cancer; 2005 Mar-Apr;15(2):361-5
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  • [Title] Extrauterine müllerian adenosarcoma associated with endometriosis and rectal villotubular adenoma: report of a case and review of the literature.
  • We describe an extrauterine adenosarcoma with a concomitant rectal tubulovillous adenoma.
  • [MeSH-major] Adenoma / complications. Adenosarcoma / etiology. Adenosarcoma / pathology. Endometriosis / complications. Neoplasms, Multiple Primary / pathology. Rectal Neoplasms / pathology

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  • (PMID = 15823126.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Parfitt JR, Driman DK: Survivin and hedgehog protein expression in serrated colorectal polyps: an immunohistochemical study. Hum Pathol; 2007 May;38(5):710-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sessile serrated adenomas and traditional serrated adenomas are pathogenetically related to inhibition of apoptosis.
  • This study compares survivin and hedgehog protein expression in serrated polyps and tubulovillous adenomas.
  • Biopsies of sessile serrated adenomas (48) and traditional serrated adenomas (10) diagnosed during 2005 were retrieved from our files.
  • Biopsies of normal mucosa (10), hyperplastic polyps (14), and tubulovillous adenomas (22) were used for comparison.
  • Traditional serrated adenomas were also compared to sessile serrated adenomas with foci of cytological dysplasia (11 cases) with respect to MLH1 and p53 expression.
  • Sessile serrated adenomas showed high-grade nuclear and cytoplasmic expression of survivin at the bottom of crypts more frequently than tubulovillous adenomas (60% versus 18%, P = .001 [nuclear]; 54% versus 18%, P = .005 [cytoplasm]), the latter showing a top-heavy pattern of staining.
  • Survivin expression in hyperplastic polyps was similar to sessile serrated adenomas, being bottom-heavy, whereas traditional serrated adenomas showed diffuse staining throughout crypts.
  • Although traditional serrated adenomas showed high-grade expression of sonic hedgehog more frequently than tubulovillous adenomas (90% versus 18%; P < .001), sonic hedgehog, patched, and smoothened expression was low grade among normal mucosa, hyperplastic polyps, and sessile serrated adenomas.
  • All cytological dysplasias showed increased p53 expression within dysplastic foci, and MLH1 was also lost within dysplastic foci in 4 cases; traditional serrated adenomas showed intact MLH1 expression and minimal p53 expression throughout.
  • Survivin expression is localized to the bottom of crypts in sessile serrated adenomas and hyperplastic polyps, whereas tubulovillous adenomas show top-heavy expression.
  • Traditional serrated adenomas express survivin throughout crypts, suggesting intersection between the serrated and conventional adenoma-cancer pathways.
  • Sonic hedgehog up-regulation is characteristic of traditional serrated adenomas, distinguishing this entity from other colorectal polyps.
  • [MeSH-major] Adenoma, Villous / metabolism. Hedgehog Proteins / metabolism. Intestinal Polyps / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / metabolism. Carrier Proteins / metabolism. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Nuclear Proteins / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17391730.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BIRC5 protein, human; 0 / Carrier Proteins; 0 / Hedgehog Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / MLH1 protein, human; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53
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31. Antillon MR, Bartalos CR, Miller ML, Diaz-Arias AA, Ibdah JA, Marshall JB: En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video). Gastrointest Endosc; 2008 Feb;67(2):332-7
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  • [Title] En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video).
  • PATIENTS: A 53-year-old patient, with a 14-cm tubulovillous adenoma of the rectum, which, at its maximal extent, involved two thirds of the circumference of the rectum.
  • [MeSH-major] Adenoma / surgery. Anal Canal / pathology. Electrocoagulation / methods. Rectal Neoplasms / surgery. Thoracoscopy / methods

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  • (PMID = 18226698.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Jones M, Helliwell P, Pritchard C, Tharakan J, Mathew J: Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship? World J Surg Oncol; 2007;5:51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Paraffin processed colonic tissue blocks of normal colonic mucosa (n = 60), and patients diagnosed as adenoma (n = 60), and adenocarcinoma (n = 60) were retrieved from our archive; the adenoma group included tubular (n = 20), tubulovillous (n = 20) and villous adenomas (n = 20).
  • RESULTS: Significant numbers of Helicobacter pylori were identified in tubular adenomas (OR = 11.13; 95%CI = 1.62-76.70), tubulovillous adenomas (OR = 10.45; 95%CI = 1.52-71.52) and adenocarcinomas (OR = 8.13; 95%CI = 1.40-46.99) compared to controls: there was no association in numbers of Helicobacter pylori and villous adenomas (OR = 2.95; 95%CI = 0.29-9.96).
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / microbiology. Adenoma / epidemiology. Adenoma / microbiology. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Female. Humans. Incidence. Intestinal Mucosa / microbiology. Intestinal Mucosa / pathology. Male. Middle Aged. Odds Ratio. Pilot Projects. Reference Values. Risk Assessment. Sampling Studies. Sensitivity and Specificity

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  • (PMID = 17498313.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Bacterial
  • [Other-IDs] NLM/ PMC1885433
  • [General-notes] NLM/ Original DateCompleted: 20070807
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33. Otake S, Takeda H, Suzuki Y, Fukui T, Watanabe S, Ishihama K, Saito T, Togashi H, Nakamura T, Matsuzawa Y, Kawata S: Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res; 2005 May 15;11(10):3642-6
The Lens. Cited by Patents in .

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  • [Title] Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance.
  • To investigate whether visceral fat accumulation contributes to colorectal carcinogenesis, we examined its accumulation and the levels of the adipose tissue-derived hormone adiponectin in Japanese patients with colorectal adenoma.
  • EXPERIMENTAL DESIGN: Fifty-one consecutive Japanese patients ages >/=40 years and with colorectal adenoma were subjected to measurement of visceral fat area by computed tomography scanning and plasma adiponectin concentration.
  • RESULTS: The patients with colorectal adenoma showed significantly more visceral fat area and significantly less plasma adiponectin concentration in comparison with the controls [odds ratio (OR), 2.19; 95% confidence interval (95% CI), 1.47-3.28; P < 0.001 and OR, 0.24; 95% CI, 0.14-0.41; P < 0.001, respectively] by logistic regression analysis.
  • HOMA-IR index was also associated with colorectal adenoma (OR 2.60; 95% CI, 1.20-5.64; P = 0.040).
  • Visceral fat area and adiponectin were associated with adenoma number (1, 2, >/= 3), the size of the largest adenoma (<10 and >/=10 mm), and adenoma histology (tubular and tubulovillous/villous).
  • CONCLUSIONS: These results suggest an association of visceral fat accumulation and decreased plasma adiponectin concentration with colorectal adenoma in Japanese patients.
  • [MeSH-major] Adenoma / physiopathology. Adipose Tissue. Body Composition. Colorectal Neoplasms / physiopathology. Insulin Resistance. Intercellular Signaling Peptides and Proteins / blood

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  • (PMID = 15897559.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Intercellular Signaling Peptides and Proteins
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34. Yoo TW, Park DI, Kim YH, Kim HS, Kim WH, Kim TI, Kim HJ, Yang SK, Byeon JS, Lee MS, Jung IK, Chung MK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS, Song JS: Clinical significance of small colorectal adenoma less than 10 mm: the KASID study. Hepatogastroenterology; 2007 Mar;54(74):418-21
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  • [Title] Clinical significance of small colorectal adenoma less than 10 mm: the KASID study.
  • BACKGROUND/AIMS: Polypectomy is the current modality of choice to prevent benign colorectal adenoma from progressing to an invasive cancer.
  • However, in cases of small colorectal adenoma, it remains unclear as to whether polypectomy is actually an effective treatment modality.
  • We evaluated the clinical significance of polypectomy in cases of small colorectal adenomas, measuring less than 10 mm.
  • A total of 5996 colorectal adenomas were detected and divided into 5 groups according to their size (Group 1; 1-5 mm, Group 2; 6-7 mm, Group 3; 8-9 mm, Group 4; 10-19 mm, Group 5; more than 20 mm).
  • The term 'advanced adenoma' refers here to tubular adenomas with diameters of at least 10 mm, or to tubulovillous, villous, or high-grade dysplasia, irrespective of size.
  • RESULTS: As the sizes of the adenomas increased, the prevalence of advanced adenoma was also observed to increase.
  • In Groups 2 and 3, the prevalence of tubulovillous or villous adenoma were higher than was expected (5.2% and 6.6%, p < 0.001).
  • CONCLUSIONS: In cases of small colorectal adenomas, measuring between 6 and 9 mm, the prevalence of cancer was at least as high as that seen in the cases of colorectal adenomas measuring between 10 and 19 mm.
  • Therefore, small colorectal adenomas measuring between 6 and 9 mm should not be ignored, in order to decrease the prevalence of colorectal cancer.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / pathology. Adenoma, Villous / surgery. Adult. Aged. Cell Transformation, Neoplastic / pathology. Cohort Studies. Colonoscopy. Female. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Male. Middle Aged. Risk Factors

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  • (PMID = 17523287.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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35. Uner A, Ebinc FA, Akyurek N, Unsal D, Mentes BB, Dursun A: Vascular endothelial growth factor, c-erbB-2 and c-erbB-3 expression in colorectal adenoma and adenocarcinoma. Exp Oncol; 2005 Sep;27(3):225-8
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  • [Title] Vascular endothelial growth factor, c-erbB-2 and c-erbB-3 expression in colorectal adenoma and adenocarcinoma.
  • METHODS: Sections of adenoma, intramucosal carcinoma and adenocarcinoma were evaluated by immunohistochemistry in 85 malignant and 37 benign colorectal neoplasms for the expression of VEGF, c-erbB-2 and c-erbB-3 considering clinicopathological variables.
  • RESULTS: VEGF was detected in comparable percentages of all neoplasm types while c-erbB-2 expression was detectable more frequently in adenoma than adenocarcinoma cases (65% vs 43%).
  • Except for the correlation of c-erbB-3 expression with Dukes' staging, there was no correlation between the studied markers and grade of differentiation, Dukes' stage and localization of colorectal adenocarcinoma. c-erbB-3 expression was seen more frequently in tubular adenomas, while c-erbB-2 expression was higher in tubulovillous and villous types.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Receptor, ErbB-2 / biosynthesis. Receptor, ErbB-3 / biosynthesis. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 16244586.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptor, ErbB-3
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36. Huang WY, Chatterjee N, Chanock S, Dean M, Yeager M, Schoen RE, Hou LF, Berndt SI, Yadavalli S, Johnson CC, Hayes RB: Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev; 2005 Jan;14(1):152-7
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  • [Title] Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.
  • Cigarette smoking is a risk factor for colorectal adenoma, a precursor of colorectal cancer.
  • Among participants randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we evaluated risks for advanced adenoma in relation to cigarette use and these two EPHX1 variants.
  • We compared 772 cases with advanced adenoma (adenoma >/=1 cm or containing high-grade dysplasia or villous, including tubulovillous, elements) of the distal colon (left-sided, descending colon and sigmoid or rectum) to 777 gender- and age-matched controls who were screen-negative for left-sided adenoma.
  • Compared to those with homozygous genotypes predicting low EPHX1 activity, advanced adenoma risks tended to be elevated for carriers of (113)TyrTyr [odds ratios (OR), 1.5; 95% confidence intervals (CI), 1.0-2.2] and (139)ArgArg (OR, 1.4; 95% CI, 0.8-2.5) and for subjects who carried a greater number of the alleles ((113)Tyr or (139)Arg) associated with high predicted enzymatic activity (P(trend) = 0.03).
  • In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Epoxide Hydrolases / genetics. Polymorphism, Genetic. Smoking / adverse effects

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  • (PMID = 15668489.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.3.2.- / Epoxide Hydrolases
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37. Koebrugge B, Bosscha K, Ernst MF: Transanal endoscopic microsurgery for local excision of rectal lesions: is there a learning curve? Dig Surg; 2009;26(5):372-7

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  • All patients undergoing TEM for tubulovillous adenoma or carcinoma between 2002 and 2007 were included.
  • Postoperative staging revealed 77 tubulovillous adenomas, 22 stage T1, 5 stage T2 and 1 stage T3 carcinomas; tumor resection was radical in 86%.
  • [MeSH-major] Adenoma, Villous / surgery. Carcinoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • [Copyright] (c) 2009 S. Karger AG, Basel.
  • (PMID = 19923824.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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38. Doornebosch PG, Bronkhorst PJ, Hop WC, Bode WA, Sing AK, de Graaf EJ: The role of endorectal ultrasound in therapeutic decision-making for local vs. transabdominal resection of rectal tumors. Dis Colon Rectum; 2008 Jan;51(1):38-42

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  • However, feasibility of endorectal ultrasound and its role in therapeutic decision-making in presumed rectal adenomas is sparsely studied.
  • METHODS: Endorectal ultrasound was performed in 268 tumors referred for local excision because biopsies showed tubulovillous adenoma.
  • In diagnosing tubulovillous adenomas, sensitivity and specificity of endorectal ultrasound was 89 and 86 percent, respectively.
  • CONCLUSIONS: Endorectal ultrasound is technically feasible in almost all presumed rectal adenomas, referred for local excision.
  • Proper endorectal ultrasound interpretation is possible in 78 percent of all presumed rectal adenomas.
  • Endorectal ultrasound is very reliable in diagnosing tubulovillous adenomas, and therapeutic decision-making regarding local excision vs. radical surgery based on endorectal ultrasound is valid.

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  • (PMID = 18038181.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Huang Y, Gong W, Su B, Zhi F, Liu S, Bai Y, Jiang B: Recurrence and surveillance of colorectal adenoma after polypectomy in a southern Chinese population. J Gastroenterol; 2010 Aug;45(8):838-45
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  • [Title] Recurrence and surveillance of colorectal adenoma after polypectomy in a southern Chinese population.
  • BACKGROUND AND AIM: Repeat colonoscopy is often performed within a short time after polypectomy due to the fear that colorectal adenomas were missed during the initial colonoscopy or that new adenomas have developed.
  • The aim of this study was to estimate the actual recurrence rate of adenoma and its association with the length of the surveillance interval after polypectomy in a southern Chinese population.
  • The recurrence rates of adenoma and advanced adenoma and surveillance intervals after polypectomy were identified based on the features of adenomas detected on initial colonoscopy.
  • RESULTS: The recurrence rates of advanced adenoma in patients with non-advanced adenoma on the initial colonoscopy were 0.9, 3.9, 5.8, and 29.2% during surveillance intervals of 1-3, 3-5, 5-10, and 10-20 years post-initial colonoscopy; for patients with advanced adenoma on the initial colonoscopy, the recurrence rates were 3.8, 13.1, 34.7, and 52.0% during the same surveillance intervals, respectively.
  • Older age (p < 0.05 for trend) and male sex [hazard ratio (HR) 2.11, 95% confidence interval (CI) 1.27-3.53] were significantly associated with recurrence for advanced adenoma, as were the size and number of baseline adenoma (p < 0.05 for trend), tubulovillous, villous adenoma (HR 2.57, 95% CI 1.24-5.32), and high-grade dysplasia (HR 1.61, 95% CI 1.07-2.42).
  • When 5% of patients had recurring advanced adenoma, the surveillance interval was estimated to be 6.9 (95% CI 6.3-12.2) years in the low-risk group and 3.0 (95% CI 2.7-3.2) years in the high-risk group.
  • CONCLUSIONS: Among our patient group, the recurrence of advanced adenoma after polypectomy increased with the length of the surveillance interval.
  • Based on our results, a 3-year follow-up of patients after polypectomy could be effective in preventing the recurrence of advanced adenoma in high-risk patients.
  • [MeSH-major] Adenoma / diagnosis. Colonic Polyps / surgery. Colonoscopy / methods. Colorectal Neoplasms / diagnosis

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  • (PMID = 20336471.001).
  • [ISSN] 1435-5922
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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40. Spring KJ, Zhao ZZ, Karamatic R, Walsh MD, Whitehall VL, Pike T, Simms LA, Young J, James M, Montgomery GW, Appleyard M, Hewett D, Togashi K, Jass JR, Leggett BA: High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology; 2006 Nov;131(5):1400-7
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  • [Title] High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy.
  • This prospective study examined the prevalence of sessile serrated adenomas and determined the incidence of BRAF and K-ras mutations in different types of polyps.
  • Most (60%) were adenomas (tubular adenomas, tubulovillous adenomas), followed by hyperplastic polyps (29%), sessile serrated adenomas (SSAs; 9%), traditional serrated adenomas (0.7%), and mixed polyps (1.7%).
  • Adenomas were more prevalent in the proximal colon (73%), as were SSAs (75%), which tended to be large (64% >5 mm).
  • BRAF mutation was rare in adenomas (1/248 [0.4%]) but common in SSAs (78%), traditional serrated adenomas (66%), mixed polyps (57%), and microvesicular hyperplastic polyps (70%).
  • K-ras mutations were significantly associated with goblet cell hyperplastic polyps and tubulovillous adenomas (P < .001).
  • [MeSH-major] Adenoma / genetics. Colonic Neoplasms / genetics. Colonoscopy. Mutation. Proto-Oncogene Proteins B-raf / genetics

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  • [CommentIn] Gastroenterology. 2006 Nov;131(5):1631-4 [17067594.001]
  • (PMID = 17101316.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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41. Zhang WW, Ren BJ, Tong HS, Zhang YL, Jiang P: [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 May;9(3):250-2
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  • [Title] [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases].
  • OBJECTIVE: To explore the endoscopic and histopathological morphology of large intestinal serrated adenomas (SA).
  • RESULTS: Forty-seven of the 71 serrated adenomas were protruded (sessile 23, semipedunculated 5, pedunculated 23) and 24 were superficial (flat 16, laterally spreading 8).
  • Histopathologically, SA contained tubular glands in 53, tubulovillous glands in 9 and villous glands in 9 cases.
  • Most IV and III L pit SAs presented villous glands (64%) and tubular glands (68%), respectively.
  • [MeSH-major] Adenoma / pathology. Colonoscopy. Colorectal Neoplasms / pathology

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  • (PMID = 16721690.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
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42. Mizoshita T, Tsukamoto T, Inada KI, Hirano N, Tajika M, Nakamura T, Ban H, Tatematsu M: Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. Histol Histopathol; 2007 03;22(3):251-60
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  • [Title] Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon.
  • MUC2 expression demonstrated a significant decrease from tubular/tubulovillous adenomas with moderate atypia, through intramucosal carcinomas, to cancers with submucosal invasion (P<0.0001).
  • Expression of MUC5AC also decreased significantly with progression according to the tubular/tubulovillous adenoma-carcinoma sequence, carcinomas with villous adenomatous components having a higher level compared with their tubular adenomatous counterparts, suggesting differences in the pathway of malignant transformation.
  • Cdx2 nuclear expression was maintained in all of the adenomas and early carcinomas examined.
  • CONCLUSIONS: Our data suggest that the reduction of MUC2 expression may be associated with the occurrence and progression of colorectal carcinomas in both adenoma-carcinoma sequence pathway and de novo carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Villous / metabolism. Colorectal Neoplasms / metabolism. Mucins / metabolism

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  • (PMID = 17163399.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Microfilament Proteins; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins; 0 / villin
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43. Kinney TP, Merel N, Hart J, Joseph L, Waxman I: Microsatellite analysis of sporadic flat and depressed lesions of the colon. Dig Dis Sci; 2005 Feb;50(2):327-30

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  • Of these specimens, eight were tubular adenomas, three were tubulovillous adenomas, and five were carcinomas in situ.
  • [MeSH-major] Adenoma, Villous / genetics. Colonic Neoplasms / genetics. Microsatellite Repeats

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  • (PMID = 15745095.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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44. Greenley CT, Ahmed B, Friedman L, Deitte L, Awad ZT: Laparoscopic management of sigmoidorectal intussusception. JSLS; 2010 Jan-Mar;14(1):137-9

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  • We report a case of sigmoidorectal intussusception caused by a large tubulovillous adenoma.

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  • (PMID = 20529540.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Elwing JE, Gao F, Davidson NO, Early DS: Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women. Am J Gastroenterol; 2006 Aug;101(8):1866-71
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  • [Title] Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women.
  • Despite several studies linking insulin resistance to increased CRC risk, there are limited data on colorectal adenoma risk in diabetic women.
  • We hypothesized that diabetic women would have increased rates of colorectal adenomas relative to a group of nondiabetic women.
  • METHODS: Colorectal adenoma rates were determined in 100 estrogen-negative women with type 2 diabetes mellitus and compared with 500 nondiabetic, estrogen-negative controls.
  • Adenomas were defined as any adenoma or advanced adenoma (villous or tubulovillous features, size >1 cm or high-grade dysplasia).
  • A multivariate model including age, race, diabetes, hypertension, hypercholesterolemia, body mass index, and nonsteroidal anti-inflammatory drug status was used to determine the independent effects of diabetes on colorectal adenoma incidence.
  • RESULTS: Diabetics as compared with nondiabetics had greater rates of any adenoma (37%vs 24%, p= 0.009) and advanced adenomas (14%vs 6%, p= 0.009).
  • Two hundred forty-five obese subjects compared with 355 nonobese subjects had a higher rate of any adenoma (32%vs 22%, p= 0.001).
  • Obese diabetics compared with nonobese, nondiabetics had greater rates of any adenoma (42%vs 23%, p< or = 0.001) and advanced adenomas (19%vs 7%, p< or = 0.001).
  • Multivariate analysis showed that adenomas and advanced adenomas were independently predicted by diabetes (p < 0.05) and adenomas by age.
  • DISCUSSION: Women with type 2 diabetes mellitus had higher rates of colorectal adenomas as compared with lean and nondiabetic women.
  • This finding adds to the evidence that type 2 diabetes is an important factor in the progression of the adenoma-carcinoma sequence.

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  • [CommentIn] Am J Gastroenterol. 2007 Feb;102(2):466-7 [17311671.001]
  • [CommentIn] Am J Gastroenterol. 2007 Mar;102(3):692 [17335459.001]
  • (PMID = 16790036.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK056341-05S2; United States / NIDDK NIH HHS / DK / P30 DK056341; United States / NHLBI NIH HHS / HL / HL38180; None / None / / P30 DK056341-06; United States / NIDDK NIH HHS / DK / P30 DK056341-06; United States / NIDDK NIH HHS / DK / DK52574; None / None / / P30 DK056341-05S2; United States / NIDDK NIH HHS / DK / DK56260
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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46. Kim DW, Jung SA, Park SA, Kim CG: Multifocal Colonic Lesions Detected by (18)F-FDG PET/CT: Correlation with Histopathology and Gross Specimen. Nucl Med Mol Imaging; 2010 Sep;44(3):226-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The histopathologic examination of the postoperative gross specimen revealed a tubular adenoma, a tubulovillous adenoma and an adenocarinoma.
  • The maximal standardized uptake value (SUVmax) of a tubulovillous adenoma was much higher than that of adenocarcinoma.
  • This patient could be considered as a representative case highlighting that SUVmax is not a reliable indicator for discriminating colon cancer from colonic adenomas.

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  • (PMID = 24899955.001).
  • [ISSN] 1869-3474
  • [Journal-full-title] Nuclear medicine and molecular imaging
  • [ISO-abbreviation] Nucl Med Mol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC4042939
  • [Keywords] NOTNLM ; 18F-FDG PET/CT / Colon cancer / Colonic adenoma
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47. Rennert G, Almog R, Tomsho LP, Low M, Pinchev M, Chaiter Y, Bonner JD, Rennert HS, Greenson JK, Gruber SB: Colorectal polyps in carriers of the APC I1307K polymorphism. Dis Colon Rectum; 2005 Dec;48(12):2317-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared.
  • Adenomas with a tubular component (either tubular adenomas or tubulovillous adenomas), but not villous adenomas, were significantly more frequent among carriers (37.2 percent vs. 23.6 percent, P = 0.005).
  • CONCLUSION: Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
  • [MeSH-major] Adenoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. Genes, APC. Polymorphism, Genetic

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  • (PMID = 16228836.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Ladas SD, Kitsanta P, Triantafyllou K, Tzathas C, Spiliadi C, Raptis SA: Cell turnover of serrated adenomas. J Pathol; 2005 May;206(1):62-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cell turnover of serrated adenomas.
  • Serrated adenomas of the colon are characterized by epithelial neoplasia combining the architectural features of hyperplastic polyps and the cytological features of adenomas.
  • The aim of this study was to investigate epithelial cell proliferation, apoptosis, and oncoprotein expression in serrated adenomas.
  • Twenty-five hyperplastic polyps, 25 serrated adenomas, and 25 tubulovillous adenomas resected from the colons of 75 patients were studied by immunohistochemical staining using monoclonal antibodies against MIB-1, Bcl-2, Bax, p53, and the TUNEL method for the detection of apoptosis.
  • In serrated adenomas, the proliferation rate was significantly lower than in tubulovillous adenomas in both the lower and the upper parts of the crypts, and higher than that of hyperplastic polyps.
  • Apoptosis was also significantly lower in serrated than in tubulovillous adenomas, but higher than in hyperplastic polyps. p53 oncoprotein expression was significantly greater in both serrated and tubulovillous adenomas than in hyperplastic polyps. bcl-2 protein expression was higher only in tubulovillous adenomas.
  • Bax index was significantly different between tubullovillous and serrated adenomas, but the lowest values were observed in hyperplastic polyps.
  • Serrated adenomas are highly proliferative polyps.
  • The intermediate features between serrated adenomas, hyperplastic polyps, and tubulovillous adenomas using the antibodies analysed in this study could have implications for the rate or the mechanism of development of malignancy in this type of polyp.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology

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  • [Copyright] 2005 Pathological Society of Great Britain and Ireland
  • (PMID = 15751053.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein
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49. Darwood RJ, Wheeler JM, Borley NR: Transanal endoscopic microsurgery is a safe and reliable technique even for complex rectal lesions. Br J Surg; 2008 Jul;95(7):915-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Seventy-one lesions (13 carcinomas and 58 tubulovillous adenomas) were identified.
  • [MeSH-major] Adenoma, Villous / surgery. Carcinoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • [Copyright] (c) 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 18496889.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Dobrow MJ, Cooper MA, Gayman K, Pennington J, Matthews J, Rabeneck L: Referring patients to nurses: outcomes and evaluation of a nurse flexible sigmoidoscopy training program for colorectal cancer screening. Can J Gastroenterol; 2007 May;21(5):301-8
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  • Classifying the six patients according to the most advanced polyp histology, one patient had a negative colonoscopy (no polyps found), one patient's polyps were hyperplastic, one had a tubular adenoma, two had advanced neoplasia (tubulovillous adenomas) and one had adenocarcinoma.

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  • [CommentIn] Can J Gastroenterol. 2007 May;21(5):280-2 [17571449.001]
  • (PMID = 17505566.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 42
  • [Other-IDs] NLM/ PMC2657712
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51. Singhal M, Kang M, Narayanan S, Gupta R, Wig JD, Bal A: Duodenoduodenal intussusception. J Gastrointest Surg; 2009 Feb;13(2):386-8
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  • We present a case of duodenoduodenal intussusception secondary to a large tubulovillous adenoma causing gastric outlet and biliary obstruction in a 50-year-old female.
  • [MeSH-major] Adenoma, Villous / pathology. Duodenal Neoplasms / pathology. Intussusception / diagnosis. Intussusception / etiology

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  • (PMID = 18389325.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Eriksen JR, Ibsen PH, Gyrtrup HJ: [Granular cell tumor of the colon--Abrikossoff's tumor]. Ugeskr Laeger; 2006 May 22;168(21):2080-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathologic examination of the specimen showed a tubulovillous adenoma with moderate dysplasia and an adjacent 1 x 1 cm submucosal tumor classified as a benign GCT due to the appearance in the light microscope and immunohistochemical analysis.
  • To our knowledge, this is the first reported case of synchronic adenoma and GCT in the colon.
  • To date there is no evidence of any association or disposing factors between GCT in the colon and colonic adenomas or malignancy.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 16768929.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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53. Cole BF, Logan RF, Halabi S, Benamouzig R, Sandler RS, Grainge MJ, Chaussade S, Baron JA: Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. J Natl Cancer Inst; 2009 Feb 18;101(4):256-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.
  • Randomized clinical trials have been conducted to evaluate the effectiveness of aspirin for reducing the risk of colorectal adenomas.
  • METHODS: We combined data from all randomized double-blind placebo-controlled trials that evaluated aspirin for the prevention of colorectal adenomas.
  • We used random-effects meta-analysis to estimate risk ratios and 95% confidence intervals (CIs) for the effect of aspirin on the occurrence of adenomas and of advanced lesions (ie, tubulovillous adenomas, villous adenomas, adenomas >or=1 cm in diameter, adenomas with high-grade dysplasia, or invasive cancer).
  • Each trial evaluated aspirin for the secondary prevention of colorectal adenomas.
  • A total of 2698 participants underwent colonoscopic follow-up and were included in the analysis of adenoma occurrence and advanced-lesion occurrence after randomization.
  • Among these participants, adenomas were found in 424 (37%) of the 1156 participants allocated to placebo and in 507 (33%) of the 1542 participants allocated to any dose of aspirin.
  • The pooled risk ratio of any adenoma for any dose of aspirin vs placebo was 0.83 (95% CI = 0.72 to 0.96).
  • CONCLUSION: Aspirin is effective for the prevention of colorectal adenomas in individuals with a history of these lesions.
  • [MeSH-major] Adenoma / prevention & control. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Anticarcinogenic Agents / administration & dosage. Aspirin / administration & dosage. Colorectal Neoplasms / prevention & control. Neoplasm Recurrence, Local / prevention & control


54. Boolchand V, Olds G, Singh J, Singh P, Chak A, Cooper GS: Colorectal screening after polypectomy: a national survey study of primary care physicians. Ann Intern Med; 2006 Nov 7;145(9):654-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MEASUREMENTS: Physicians were asked when they would recommend repeated colonoscopy for a hypothetical 55-year-old man with no family history of colorectal cancer after the following 6 results on colonoscopy: hyperplastic polyp, one 6-mm tubular adenoma, two 6-mm tubular adenomas, one 12-mm tubulovillous adenoma, one 12-mm tubular adenoma with focal high-grade dysplasia, and no polyp but a previous tubular adenoma.
  • Sixty-one percent of respondents would survey a hyperplastic polyp in 5 years or less, 71% would survey a single tubular adenoma in 3 years or less, and 80% would survey 2 tubular adenomas in 3 years or less.
  • CONCLUSION: Primary care physicians recommend postpolypectomy colonoscopic surveillance more frequently than is recommended by practice guidelines, especially if the colonoscopy showed a hyperplastic polyp or a single small adenoma.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / surgery. Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Cross-Sectional Studies. Female. Follow-Up Studies. Guideline Adherence. Humans. Hyperplasia / diagnosis. Hyperplasia / surgery. Male. Middle Aged. Practice Guidelines as Topic. Risk Factors. Surveys and Questionnaires. Time Factors. United States

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  • [CommentIn] Ann Intern Med. 2007 Jun 5;146(11):820; author reply 820-1 [17548417.001]
  • [CommentIn] Ann Intern Med. 2007 Jun 5;146(11):820; author reply 820-1 [17548416.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2006 Nov 7;145(9):I26 [17088574.001]
  • (PMID = 17088578.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K05 CA90677; United States / NIDDK NIH HHS / DK / K24 DK002800
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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55. Arslan N, Dehdashti F, Siegel BA: FDG uptake in colonic villous adenomas. Ann Nucl Med; 2005 Jun;19(4):331-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG uptake in colonic villous adenomas.
  • Colonic adenomas constitute 70-80% of all colorectal polyps, and their clinical significance relates primarily to their relationship with colorectal cancer.
  • The purpose of this study was to investigate the rate of FDG-PET positivity within colonic villous adenomas.
  • A pathology database search was performed to identify all patients diagnosed with colonic villous adenoma between June 1, 1996 and December 1, 2000.
  • Patients with a pathologic diagnosis of colonic villous adenoma and who also had a FDG-PET study up to 1 month before colonoscopy were included in this study.
  • Of more than 4,000 patients, six patients were diagnosed with colonic adenoma on subsequent colonoscopy following FDG-PET study.
  • Based on the pathological findings, these 6 patients had a total of 2 villous and 9 tubulovillous adenomas.
  • Five of the 6 patients showed foci of increased FDG uptake in the region of the colon that corresponded to the villous adenoma(s) detected on colonoscopy, which accounted for a true-positive rate of 83.3% (5/6 subjects).
  • Focal lesions in the colon seen on FDG-PET examinations need to be investigated further, even though some of these will prove to be villous adenomas rather than colorectal carcinomas.
  • [MeSH-major] Adenoma, Villous / radionuclide imaging. Colorectal Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18 / pharmacokinetics. Positron-Emission Tomography / methods

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  • (PMID = 16097645.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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56. Nieuwenhuis DH, Draaisma WA, Verberne GH, van Overbeeke AJ, Consten EC: Transanal endoscopic operation for rectal lesions using two-dimensional visualization and standard endoscopic instruments: a prospective cohort study and comparison with the literature. Surg Endosc; 2009 Jan;23(1):80-6
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  • RESULTS: Between 2004 and 2006, 31 patients with a median age of 75 years (range, 33-87 years) underwent 31 TEOs for a total of 36 rectal lesions (29 tubulovillous adenomas and 7 adenocarcinomas).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Endoscopes. Endoscopy. Rectal Neoplasms / surgery. Surgery, Computer-Assisted / instrumentation

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  • (PMID = 18443874.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
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57. Molaei M, Mansoori BK, Mashayekhi R, Vahedi M, Pourhoseingholi MA, Fatemi SR, Zali MR: Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions? BMC Cancer; 2010;10:537
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A total of 454 polyp specimens comprising 36 hyperplastic polyps, 15 serrated adenomas, 258 tubular adenomas, 114 tubulovillous adenomas, and 31 villous adenomas were included in this study, and were immunostained for MUC1, MUC2, MUC5AC and MUC6 by using mucin specific antibodies.
  • RESULTS: MUC1 and MUC6 were absent in all hyperplastic polyps and their expression was higher in serrated and traditional adenomas.
  • Only 5 cases including 2 serrated adenomas, 1 tubulovillous adenoma, and 2 villous adenomas stained negative for MUC2.
  • The highest expression of MUC5AC was observed in serrated adenomas followed by tubular adenomas.

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  • [Cites] Genomics. 2000 Oct 15;69(2):196-202 [11031102.001]
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  • (PMID = 20929551.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins
  • [Other-IDs] NLM/ PMC2958948
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58. Tagaya N, Kasama K, Suzuki N, Taketsuka S, Horie K, Kubota K: Simultaneous laparoscopic treatment for diseases of the gallbladder, stomach, and colon. Surg Laparosc Endosc Percutan Tech; 2005 Jun;15(3):169-71
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  • The histopathologic diagnoses were chronic cholecystitis, leiomyoma of the stomach, and tubulovillous adenoma with severe dysplasia of the colon.
  • [MeSH-major] Adenoma, Villous / surgery. Cholecystolithiasis / epidemiology. Cholecystolithiasis / surgery. Colonic Neoplasms / surgery. Laparoscopy. Leiomyoma / surgery. Stomach Neoplasms / surgery

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  • (PMID = 15956904.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Freeman HJ, Webber DL, Meneghetti AT: An appendiceal neoplastic lesion: case report and implications for colonoscopic screening and surveillance. Can J Gastroenterol; 2009 May;23(5):379-81
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  • A 65-year-old man with a history of previously resected colonic adenomas had an apparent cecal lesion detected during colonoscopy.
  • The polyp proved to be a tubulovillous adenoma with high-grade dysplasia involving most of the body of the appendix along with the base of the cecum.
  • [MeSH-major] Adenoma, Villous / diagnosis. Appendectomy / methods. Appendiceal Neoplasms / diagnosis. Colonoscopy / methods

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  • (PMID = 19440570.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2706752
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60. John R, El-Rouby NM, Tomasetto C, Rio MC, Karam SM: Expression of TFF3 during multistep colon carcinogenesis. Histol Histopathol; 2007 07;22(7):743-51
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  • Colonic tissues representing colitis, adenomatous polyposis, tubulovillous adenoma, and mucoid/adeno-carcinomas were processed for immunohistochemistry using an antibody specific for human TFF3.
  • The data showed marked down-regulation of TFF3 expression in adenomatous polyposis, then TFF3 expression returns to about control level during adenoma and remains high during mucoid- and adeno-carcinomas.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Adenoma, Villous / chemistry. Adenomatous Polyposis Coli / chemistry. Colitis / metabolism. Colonic Neoplasms / chemistry. Peptides / analysis

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  • (PMID = 17455148.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Peptides; 0 / Proliferating Cell Nuclear Antigen; 0 / TFF3 protein, human; 0 / Trefoil Factor-3
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61. Senapati S, Ho SB, Sharma P, Das S, Chakraborty S, Kaur S, Niehans G, Batra SK: Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon. J Clin Pathol; 2010 Aug;63(8):702-7
The Lens. Cited by Patents in .

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  • Similarly, MUC17 expression was decreased in hyperplastic polyps (p=0.0003), tubular and tubulovillous adenomas (p<0.0001) and colon cancers (p<0.0001).

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  • (PMID = 20702471.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA133774-04; United States / NCI NIH HHS / CA / R01 CA078590-13; United States / NCI NIH HHS / CA / U01 CA111294; United States / NIDDK NIH HHS / DK / R24 DK080506; United States / NCI NIH HHS / CA / CA131944-04; United States / NCI NIH HHS / CA / CA133774; United States / NCI NIH HHS / CA / R01 CA078590; United States / NCI NIH HHS / CA / R01 CA131944; United States / NCI NIH HHS / CA / CA78590; United States / NCI NIH HHS / CA / CA133774-04; United States / NCI NIH HHS / CA / R01 CA133774; United States / NIDDK NIH HHS / DK / DK080506; United States / NCI NIH HHS / CA / CA131944; United States / NCI NIH HHS / CA / R01 CA131944-04; United States / NCI NIH HHS / CA / CA111294
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MUC17 protein, human; 0 / Mucins
  • [Other-IDs] NLM/ NIHMS254309; NLM/ PMC2997570
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62. Fu KI, Hamahata Y, Tsujinaka Y: Early colon cancer within a diverticulum treated by magnifying chromoendoscopy and laparoscopy. World J Gastroenterol; 2010 Mar 28;16(12):1545-7
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  • We report a unique case of intramucosal carcinoma in a tubulovillous adenoma arising from a single diverticulum.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Colectomy. Colonic Neoplasms / surgery. Colonic Polyps / surgery. Colonoscopy / methods. Diverticulum, Colon / complications. Laparoscopy

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  • (PMID = 20333800.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2846265
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63. Bansal A, Liu X, McGregor DH, Singh V, Hall S: Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series. Am J Med Sci; 2010 Oct;340(4):296-300
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  • [Title] Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series.
  • Although EGFR is described to be overexpressed in adenomas, to the authors' knowledge, its relationship with advanced features in adenomas and as a marker for adenoma progression has not been studied.
  • Subsequently, a validation group of 95 adenomas from 16 patients were graded semiquantitatively for EGFR staining.
  • Size and villous features of the adenomas were evaluated by 2 independent pathologists and compared with EGFR expression.
  • To be classified as advanced, adenomas needed to be greater than 1 cm and fulfill 1 of the 2 criteria-villous component >20% to 25% or presence of high-grade dysplasia.
  • RESULTS: In the index case, the large 5.5 cm tubulovillous adenoma had EGFR positivity in all of its neoplastic cells, whereas another 2 cm tubular adenoma with focal villous features had 30% EGFR positivity.
  • In 95 adenomas from 16 additional patients, there was a significant correlation of EGFR positivity with adenoma size ≥1 cm and villous features (all P < 0.001).
  • The odds of EGFR expression in advanced adenomas were 17.3 times higher than nonadvanced adenomas (P < 0.001).
  • CONCLUSIONS: These findings suggest that EGFR overexpression is associated with advanced colorectal adenomas.
  • Further larger studies are needed to explore EGFR expression as a biomarker for adenoma progression.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Receptor, Epidermal Growth Factor / metabolism

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  • (PMID = 20622650.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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64. Li J, Lv YM, Jin Z, Cui RL: [The effects of sulindac on the pathology of colorectal remnant polyps of familial adenomatous polyposis (FAP) patients]. Beijing Da Xue Xue Bao; 2005 Aug 18;37(4):371-3
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  • OBJECTIVE: To evaluate the long-term effectiveness of sulindac on the pathology of colorectal adenomas of familial adenomatous polyposis (FAP) patients.
  • RESULTS: Before the study, 90.8% of adenoma biopsies were tubular, while 9.2% was tubulovillous adenoma.
  • After sulindac treatment, 99.8% of adenoma biopsies were tubular, while 0.2% tubulovillous adenoma.
  • Minor flat elevation and erythema were found during the treatment, in which approximately 65% was adenoma.
  • CONCLUSION: Long-term use of sulindac seems to be effective in reducing dysplasia grade and tubulovillous adenoma of retained colorectal adenoma of FAP patients.
  • Minor flat elevation and erythema may be the lesions appearing during the regression of adenoma.

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  • (PMID = 16086054.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 184SNS8VUH / Sulindac
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65. Selcuk H, Korkmaz M, Kanbay M, Tore E, Sumer H, Unal H, Yeloglu O, Gur G, Bilezikci B, Demirhan B, Yilmaz U, Boyacioglu S: Total colonic polyp diameter: a marker for the risk of malignancy? Hepatogastroenterology; 2008 May-Jun;55(84):936-9
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • The polyps were further categorized by histopathologic component as "unfavorable" or "favorable" and were divided into 2 groups: group 1 (those identified as carci noma, carcinoma in situ, villous adenoma, and tubulovillous adenoma with a villous component of more than 25%) and group 2 (mixed adenomatous polyps with various degrees of hyperplastic or inflammatory components and adenomas with a tubular component of more than 75%).
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Adenomatous Polyps / pathology. Adult. Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Colonoscopy. Female. Humans. Male. Middle Aged. Prognosis. Risk Factors

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  • (PMID = 18705301.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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66. Wasilewicz MP, Kołodziej B, Bojułko T, Kaczmarczyk M, Sulzyc-Bielicka V, Bielicki D, Ciepiela K: Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis. Int J Colorectal Dis; 2010 Sep;25(9):1079-85
The Lens. Cited by Patents in .

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  • [Title] Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
  • Our purpose was to investigate the possible connection between 5-LOX expression and colon carcinogenesis by characterizing 5-LOX expression in histologically different colonic adenomas, determining the relationship between high expression of 5-LOX and various conventional clinicopathological features of adenomas, and finally characterizing the histological localization of cells with 5-LOX overexpression.
  • METHODS: A total of 111 patients were examined and 120 histologically different colonic adenomas analyzed (including four cases of intramucosal adenocarcinoma in a polyp).
  • RESULTS: There was a significant correlation between high 5-LOX expression and patient age, increased polyp size, high grade of intraepithelial neoplasia, villous and tubulovillous adenoma, and histological epithelial localization.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Arachidonate 5-Lipoxygenase / metabolism. Colonic Neoplasms / enzymology. Colonic Neoplasms / pathology. Precancerous Conditions / enzymology. Precancerous Conditions / pathology

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  • (PMID = 20549218.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.13.11.34 / Arachidonate 5-Lipoxygenase
  • [Other-IDs] NLM/ PMC2912725
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67. Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland CR: Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps. Cancer Epidemiol Biomarkers Prev; 2005 Sep;14(9):2253-6
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps.
  • BACKGROUND: Serrated adenomas are characterized by serrated crypts with dysplasia, and are distinguished from other polyps by their histology, but the genetic basis of serrated adenomas is unknown.
  • We investigated genetic alterations in colorectal polyps to determine if a specific pattern were associated with serrated adenomas.
  • METHODS: Sixty-six small (<10 mm) colorectal polyps were studied, including 11 hyperplastic polyps, 27 serrated adenomas, 9 tubular adenomas, 6 tubulovillous adenomas, and 3 villous adenomas.
  • Allelic imbalance of 18q was significantly more common (P < 0.05), whereas allelic imbalance of 5q and K-ras mutations were significantly less common (P < 0.05) in serrated adenomas compared with other polyps.
  • CONCLUSIONS: Serrated adenomas are significantly more likely to have allelic imbalance at 18q than other types of adenomas, and significantly less likely to have allelic imbalance at 5q or K-ras mutations.
  • Serrated adenomas seem to evolve through a different genetic pathway than other types of polyps in the colon.

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  • (PMID = 16172239.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090231-05; United States / NCI NIH HHS / CA / R01 CA090231; United States / NCI NIH HHS / CA / R-01 CA72851; United States / NCI NIH HHS / CA / R01 CA090231-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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68. Mittal R, Perakath B, Chase S, Jesudason MR, Nayak S: Transanal excision of anorectal lesions--a single centre experience. Trop Gastroenterol; 2010 Jan-Mar;31(1):65-8

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  • Tubulovillous adenomas and hyperplastic polyps were the commonest benign lesions.

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  • (PMID = 20860237.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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69. Kiziltaş S, Sezgin Ramadan S, Topuzoğlu A, Küllü S: Does the severity of tissue eosinophilia of colonic neoplasms reflect their malignancy potential? Turk J Gastroenterol; 2008 Dec;19(4):239-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This retrospective study aimed to investigate the frequency and intensity of tissue eosinophilia in various colonic neoplasms, including serrated adenomas.
  • METHODS: We evaluated 448 colonic neoplasms to determine eosinophilic infiltration: 96 hyperplastic polyps, 50 serrated adenomas, 19 flat adenomas, 154 tubular adenomas, 71 tubulovillous adenomas, 13 villous adenomas and 45 adenocarcinomas.
  • RESULTS: Moderate (46.7%) and marked (52.9%) intensity were noted in all colonic adenomas.
  • Mostly moderate eosinophilic infiltration was observed in serrated adenomas.
  • CONCLUSIONS: Our findings suggest that the intensity of tissue eosinophilia is most prominent in adenomas including serrated adenomas and is diminished from adenoma to carcinoma.

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  • (PMID = 19119482.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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70. V Schönfeld J, Hinzmann S: Missed colonic adenomas in routine primary care endoscopy: a prospective tandem colonoscopy study. Z Gastroenterol; 2010 Oct;48(10):1207-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Missed colonic adenomas in routine primary care endoscopy: a prospective tandem colonoscopy study.
  • Several lines of independent evidence, however, suggest that a significant number of small adenomas and also some advanced lesions are missed even by experienced endoscopists.
  • A total of 98 neoplastic lesions were identified in 34 patients at the index colonoscopy, an additional 53 adenomas were removed at the second colonoscopy, 33 of them smaller than 5 mm.
  • 25 out of 53 missed adenomas were identified between the coecum and the right colonic flexure.
  • 12 of the additional lesions were considered significant lesions (larger than 10 mm or tubulovillous adenoma), nine of these were located between the coecum and the right colonic flexure.
  • In 24 patients repeat colonoscopy detected adenomas not described in the original report.
  • About one-third of adenomas were missed in 40 routine colonoscopies, most of them only small and therefore probably of little clinical significance.
  • Adenomas in the right colon seem to be a particular problem.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Colonoscopy / statistics & numerical data. Medical Errors / prevention & control

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20886425.001).
  • [ISSN] 1439-7803
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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71. Koh DC, Luchtefeld MA, Kim DG, Attal H, Monroe T, Ingersoll K: Microsatellite instability and MLH1 hypermethylation - incidence and significance in colorectal polyps in young patients. Colorectal Dis; 2007 Jul;9(6):521-6
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  • The original Bethesda criteria recommends MSI testing in patients <or=40 years diagnosed with adenomas.
  • About 53% of the polyps were tubulo-adenomas and 27% tubulovillous adenomas.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / genetics. Adolescent. Adult. Colonic Neoplasms / genetics. DNA Methylation. Female. Humans. Immunohistochemistry. Male. Nuclear Proteins

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  • (PMID = 17573746.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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72. Jotautas V, Strupas K, Poskus E, Seinin D: [Treatment of rectal tumors with transanal endoscopic microsurgery]. Medicina (Kaunas); 2005;41(6):470-6

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  • MATERIALS AND METHODS: The patients who had rectal adenomas and low-risk T1 carcinomas of good or moderate differentiation, with no lymphatic and vascular invasion were selected for surgery.
  • Overall 25 (52.1%) carcinomas and 23 (47.9%) adenomas were removed.
  • Twenty-six patients were followed up for 3-17 months after operation: 17 after removal of cancer and 9 after removal of adenoma.
  • One (2.1%) recurrence of a tubulovillous adenoma was diagnosed.
  • CONCLUSIONS: Initial results of transanal endoscopic microsurgery obtained while treating rectal adenomas and low-risk T1 cancers are promising.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Proctoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenoma, Villous / pathology. Adenoma, Villous / radiotherapy. Adenoma, Villous / surgery. Adult. Aged. Aged, 80 and over. Biopsy. Combined Modality Therapy. Data Interpretation, Statistical. Female. Humans. Male. Microsurgery. Middle Aged. Minimally Invasive Surgical Procedures. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Rectum / pathology. Treatment Outcome

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  • (PMID = 15998984.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
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73. Yan JQ, Peng CH, Yang WP, Ding JZ, Zhou GW, Ma D, Li HW: Surgical management of benign duodenal tumours. ANZ J Surg; 2010 Jul-Aug;80(7-8):526-30
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  • The post-operative pathology results indicated 5 cases of adenoma, 2 cases of tubular adenoma, 2 cases of villous adenoma, 2 cases of tubulovillous adenoma, 2 cases of hamartoma and 1 case each of hamartomatous polyp, Brunner's adenoma, adenomyoma, fibromatosis and ectopic pancreas.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Adult. Aged. Anastomosis, Surgical / methods. Biopsy, Needle. Cholangiopancreatography, Endoscopic Retrograde / methods. Cohort Studies. Colectomy / methods. Duodenoscopy / methods. Female. Follow-Up Studies. Hamartoma / diagnosis. Hamartoma / pathology. Hamartoma / surgery. Humans. Immunohistochemistry. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Risk Assessment. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • [CommentIn] ANZ J Surg. 2011 Apr;81(4):300-1 [21418483.001]
  • (PMID = 20795967.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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74. Pezzoli A, Matarese V, Rubini M, Simoni M, Caravelli GC, Stockbrugger R, Cifalà V, Boccia S, Feo C, Simone L, Trevisani L, Liboni A, Gullini S: Colorectal cancer screening: results of a 5-year program in asymptomatic subjects at increased risk. Dig Liver Dis; 2007 Jan;39(1):33-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomas and cancers were found in 122 (21.7%) and 12 (2.1%) subjects, respectively.
  • Histological examination in 181 persons with lesions (32.8%) showed (most serious lesion quoted) 47 hyperplastic polyps (26% of all lesions), 2 serrated adenomas (1.1%), 68 tubular adenomas (48%), 24 tubulovillous adenomas (13.3%), 9 adenomas with high grade dysplasia (5%) and 12 adenocarcinomas (6.6%).
  • [MeSH-minor] Adenoma / diagnosis. Colonoscopy. Female. Humans. Male. Middle Aged. Pedigree. Predictive Value of Tests. Prevalence. Risk Factors

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  • (PMID = 17049323.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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75. Koebrugge B, Bosscha K, Jager G, Ernst M: Accuracy of transrectal ultrasonography in staging rectal tumors that are clinically eligible for transanal endoscopic microsurgery. J Clin Ultrasound; 2010 Jun;38(5):250-3
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  • Postoperative pathologic findings confirmed the preoperative TRUS findings in 29 patients; in 1 patient, a T3 staged tumor was an overstaged lesion biopsied as a tubulovillous adenoma.

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  • (PMID = 20186761.001).
  • [ISSN] 1097-0096
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Kristjansdottir S, Jonasson JG, Cariglia N, Thjodleifsson B: Colonic adenomas found via colonoscopy: yield and risk factors for high-grade dysplasia. Digestion; 2010;82(4):252-7
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic adenomas found via colonoscopy: yield and risk factors for high-grade dysplasia.
  • BACKGROUND AND AIMS: The adenoma-carcinoma sequence is the model for colorectal carcinoma (CRC) developing through high-grade dysplasia (HGD) to CRC.
  • The aim was to assess prevalence and location of adenomas found during colonoscopy and risk factors for HGD.
  • RESULTS: A total of 3,315 adenomas were removed from 2,385 patients.
  • HGD was found in 135 (4.1%) of the adenomas and tubulovillous/villous histology in 15.0%.
  • The prevalence of adenomas in the 50- to 69-year age group was 15.5%, and 21.5% in the >or=70-year group.
  • Independent risk factors for HGD were in the order of importance: size; multiplicity; tubulovillous/villous histology; location in rectum, and age.
  • The prevalence of HGD in the group with an adenoma size of 0.6-1.0 cm was 4.1% and in the 40- to 69-year age group it was 3.7%.
  • CONCLUSION: The study suggests a potential 15% yield per colonoscopy of adenomas in 50- to 69-year-olds.
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 20588041.001).
  • [ISSN] 1421-9867
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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77. Kadiyska TK, Kaneva RP, Nedin DG, Alexandrova AB, Gegova AT, Lalchev SG, Christova T, Mitev VI, Horst J, Bogdanova N, Kremensky IM: Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family. World J Gastroenterol; 2006 Dec 28;12(48):7848-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining.

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  • (PMID = 17203532.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
  • [Other-IDs] NLM/ PMC4087554
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78. Nusko G, Hahn EG, Mansmann U: Characteristics of metachronous colorectal adenomas found during long-term follow-up: analysis of four subsequent generations of adenoma recurrence. Scand J Gastroenterol; 2009;44(6):736-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characteristics of metachronous colorectal adenomas found during long-term follow-up: analysis of four subsequent generations of adenoma recurrence.
  • OBJECTIVE: Because of the high recurrence rates of colorectal adenomas, regular surveillance by colonoscopy has been recommended, but there is still a dearth of information on the long-term results of follow-up colonoscopy after polypectomy.
  • The aims of this study were to determine the differences between initial adenomas and metachronous lesions, to evaluate the effect of long-term surveillance and to describe the hypothetical origin of the colorectal adenoma-carcinoma sequence.
  • Statistical analysis using chi(2) testing of adenoma characteristics found in four subsequent recurrence periods was carried out, and the relative risk (RR) for the development of metachronous adenomas of advanced pathology was calculated.
  • RESULTS: In comparison with the initial findings, metachronous adenomas are generally significantly smaller lesions (p<0.00001), usually tubular in shape (p<0.00001) and bearing high-grade dysplasia less often (p<0.00001) and are usually located in the right colon (p<0.00001).
  • These differences are found between the initial and four subsequent generations of metachronous adenomas.
  • The number of synchronous adenomas is reduced only in the first recurrence (p<0.001); in the further generations equal proportions of multiplicity are found, as in the baseline examination.
  • Patients with adenomas of advanced pathology, i.e. large, tubulovillous or villous adenomas at baseline, have a significantly higher risk for large (RR 2.73; 95% CI 1.77-4.20), tubulovillous or villous (RR 1.55; 95% CI 1.06-2.25) or multiple (RR 2.45; 95% CI 1.83-3.29) metachronous adenomas at the first recurrence.
  • CONCLUSIONS: Metachronous adenomas show the uniform characteristics of being small tubular lesions rarely bearing high-grade dysplasia, usually located in the right colon.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Neoplasms, Second Primary

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  • (PMID = 19277927.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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79. Bernstein H, Prasad A, Holubec H, Bernstein C, Payne CM, Ramsey L, Dvorakova K, Wilson M, Warneke JA, Garewal H: Reduced Pms2 expression in non-neoplastic flat mucosa from patients with colon cancer correlates with reduced apoptosis competence. Appl Immunohistochem Mol Morphol; 2006 Jun;14(2):166-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Multiple samples were taken from the non-neoplastic flat mucosa of colon resections from patients with no colonic neoplasia, a tubulovillous adenoma, or an adenocarcinoma.
  • Apoptosis was assessed in polychrome-stained epoxy sections using morphologic criteria.
  • Samples from patients without colonic neoplasia had moderate to strong staining for Pms2 in cell nuclei at the base of crypts, while samples from 2 of the 3 colons with a tubulovillous adenoma, and from 6 of the 10 colons with adenocarcinomas, showed reduced Pms2 expression.

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  • (PMID = 16785784.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / 1 P50 CA95060; United States / NCI NIH HHS / CA / CA23074; United States / NCI NIH HHS / CA / CA72008
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / PMS2 protein, human; EC 6.5.1.- / DNA Repair Enzymes
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80. Meniconi RL, Caronna R, Benedetti M, Fanello G, Ciardi A, Schiratti M, Papini F, Farelli F, Dinatale G, Chirletti P: Inflammatory myoglandular polyp of the cecum: case report and review of literature. BMC Gastroenterol; 2010;10:10
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  • There was also another little polyp next to the ileocecal valve, not revealed at the colonoscopy, 0.8 cm in diameter, diagnosed as tubulovillous adenoma with low grade dysplasia.

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  • (PMID = 20102635.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2828397
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81. Psofaki V, Kalogera C, Tzambouras N, Stephanou D, Tsianos E, Seferiadis K, Kolios G: Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas. World J Gastroenterol; 2010 Jul 28;16(28):3553-60
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  • [Title] Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.
  • METHODS: DNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1 (hMLH1), Cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), and O-6-methylguanine DNA methyltransferase (MGMT), as well as their relation to MSI.
  • RESULTS: The frequency of promoter methylation for each locus increased in the sequence healthy tissue/adenoma/carcinoma.
  • MGMT and CDKN2A/p16 presented a statistically significant increase in promoter methylation between the less and more tumorigenic forms of colorectal adenomas (tubular vs tubullovillous and villous adenomas).
  • All patients with tubulovillous/villous adenomas, as well as all colorectal cancer patients, showed promoter methylation in at least one of the examined loci.
  • These findings suggest a potentially crucial role for methylation in the polyp/adenoma to cancer progression in colorectal carcinogenesis.
  • CONCLUSION: Methylation analysis of hMLH1, CDKN2A/p16, and MGMT revealed specific methylation profiles for tubular adenomas, tubulovillous/villous adenomas, and colorectal cancers, supporting the use of these alterations in assessment of colorectal tumorigenesis.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation / physiology. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Nuclear Proteins / genetics. Promoter Regions, Genetic / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20653064.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
  • [Other-IDs] NLM/ PMC2909555
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82. Rubio CA: Neoplasias of the colorectal crypts. Anticancer Res; 2005 Nov-Dec;25(6C):4551-8
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  • Colorectal cancers are often preceded by noninvasive neoplasias arising in the surface epithelium, namely tubular, tubulovillous and villous adenomas.
  • The material included 502 adenomas, 865 invasive tumours and 221 cases of ulcerative colitis (UC).
  • Over the 5-year period, the most frequent phenotype encountered was single crypt dysplasia (in all 5 colectomies from familial adenomatous polyposis patients), followed by serrated adenomas (11.2%), hyperplastic polyps (8.4%), dysplasia in UC (6.3%), pure carcinoid tumours (1.7%), signet ring cell carcinoma (1.1%), adenocarcinoid tumours (0.2%) and de novo carcinomas (0.1%).
  • In this survey, no case of Paneth cell adenoma or of cryptal neoplasia in lymphoid-associated mucosa (also known to originate from the crypts) was found.
  • [MeSH-minor] Adenoma / pathology. Adenomatous Polyposis Coli / pathology. Female. Goblet Cells / pathology. Humans. Intestinal Mucosa / pathology. Male. Paneth Cells / pathology

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  • (PMID = 16334140.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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83. Alexander S, Bourke MJ, Williams SJ, Bailey A, Co J: EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos). Gastrointest Endosc; 2009 Jan;69(1):66-73
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  • [Title] EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos).
  • OBJECTIVE: Our purpose was to evaluate the efficacy and safety of EMR of large (>15 mm) duodenal adenomas.
  • PATIENTS: Patients with large (>15 mm) sporadic nonampullary duodenal adenomas managed by a standardized technique who were referred by other specialist endoscopists for endoscopic treatment.
  • METHODS: Five-year data from patients undergoing EMR for large duodenal adenomas were reviewed retrospectively.
  • Post-EMR histologic examination revealed mucosal adenocarcinoma in 1, low-grade tubulovillous adenoma (TVA) in 16, high- or focal high-grade TVA in 3 patients, and 1 with both high-grade TVA and carcinoid.
  • During follow-up, 5 patients had minor residual adenomas that were treated successfully with snare resection and/or argon plasma coagulation.
  • CONCLUSION: EMR for large sporadic nonampullary duodenal adenomas is a safe and effective technique.
  • [MeSH-major] Adenoma / surgery. Duodenal Neoplasms / surgery. Duodenoscopy / methods. Intestinal Mucosa / surgery. Neoplasm Invasiveness / pathology

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  • (PMID = 18725157.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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84. Savas B, Ensari A, Percinel S, Kuzu I, Kuzu MA, Bektas M, Cetinkaya H, Kursun N: The significance of beta-catenin, E-cadherin, and P-cadherin expressions in neoplastic progression of colorectal mucosa: an immunohistochemical study. Acta Gastroenterol Belg; 2007 Oct-Dec;70(4):339-44
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  • PATIENTS AND METHODS: Core tissue biopsies were taken from paraffin-embedded tissue blocks of 167 cases including 26 normal mucosae (NM), 99 colorectal polyps (10 hyperplastic polyps (HP), 8 traditional serrated (TSA), 17 tubular (TA), 37 tubulovillous (TVA), and 27 villous adenomas (VA)), 14 adenomas with intramucosal carcinoma (ACA), and 28 colorectal cancers (CCA).
  • E-cadherin and P-cadherin expressions in adenomas suggest that these molecules might have role in adenoma formation though not necessarily be involved in neoplastic progression.
  • [MeSH-minor] Adenoma / pathology. Adenoma, Villous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma / pathology. Carcinoma in Situ / pathology. Cell Membrane / ultrastructure. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Disease Progression. Female. Humans. Hyperplasia. Immunohistochemistry. Intestinal Polyps / pathology. Male. Middle Aged. Tissue Array Analysis

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  • (PMID = 18330089.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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85. Gentner B, Kraus C, Schwab D, Benninger J, Wein A, Hahn EG, Brueckl WM: [A case of attenuated familial adenomatous polyposis coli (AFAP)]. Z Gastroenterol; 2005 Jun;43(6):591-5
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  • We describe an asymptomatic female patient who was diagnosed with multiple tubular and tubulovillous adenomas in the right-sided colon on routine colonoscopy at the age of 59 years.

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  • (PMID = 15986289.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
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86. Glatz K, Pritt B, Glatz D, Hartmann A, O'Brien MJ, Blaszyk H: A multinational, internet-based assessment of observer variability in the diagnosis of serrated colorectal polyps. Am J Clin Pathol; 2007 Jun;127(6):938-45
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  • This Internet-based quiz (http://kathrin.unibas.ch/polyp/) tested the diagnostic variability of 168 pathologists in the diagnosis of 20 colorectal polyps on 3 representative images, including hyperplastic polyps (HPs), traditional serrated adenomas (TSAs), sessile serrated adenomas (SSAs), and tubulovillous adenomas (TVAs).

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  • [ErratumIn] Am J Clin Pathol. 2007 Aug;128(2):348
  • (PMID = 17509991.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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87. Kung JW, Levine MS, Glick SN, Lakhani P, Rubesin SE, Laufer I: Colorectal cancer: screening double-contrast barium enema examination in average-risk adults older than 50 years. Radiology; 2006 Sep;240(3):725-35
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  • The remaining 14 patients had a total of 21 neoplastic lesions 1 cm or larger, including 11 tubular adenomas, seven tubulovillous adenomas, one villous adenoma with marked dysplasia, and two cancers.

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  • [Copyright] (c) RSNA, 2006.
  • (PMID = 16837671.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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88. Winkler A, Hinterleitner TA, Högenauer C, Hauser H, Langner C: Juvenile polyposis of the stomach causing recurrent upper gastrointestinal bleeding. Eur J Gastroenterol Hepatol; 2007 Jan;19(1):87-90
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  • Colonoscopy including the terminal ileum revealed a single tubulovillous adenoma, but no hamartomatous polyps, rendering a final diagnosis of juvenile polyposis of the stomach.

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  • (PMID = 17206083.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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89. O'Connor DJ, Feinberg E, Jang J, Vemulapalli P, Camacho D: Single-incision laparoscopic-assisted right colon resection for cancer. JSLS; 2010 Oct-Dec;14(4):558-60

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  • METHODS: A 77-year-old woman with a tubulovillous adenoma in her cecum underwent a laparoscopic right colectomy using a single port placed through the umbilicus.

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  • (PMID = 21605522.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3083049
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90. Rea JD, Lockhart ME, Yarbrough DE, Leeth RR, Bledsoe SE, Clements RH: Approach to management of intussusception in adults: a new paradigm in the computed tomography era. Am Surg; 2007 Nov;73(11):1098-105
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  • Three had ileocolic disease, including cecal cancer (one), metastatic melanoma (one) and idiopathic (one; whereas five patients had colocolonic intussusception from colon cancer (three), tubulovillous adenoma (one), and local inflammation (one).

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  • (PMID = 18092641.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Rubio CA, Nesi G, Messerini L, Zampi GC, Mandai K, Itabashi M, Takubo K: The Vienna classification applied to colorectal adenomas. J Gastroenterol Hepatol; 2006 Nov;21(11):1697-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The Vienna classification applied to colorectal adenomas.
  • In this study, that classification is applied to colorectal adenomas.
  • METHODS: Colorectal adenomas from 1552 patients were histologically classified according to the categories listed in Vienna: category 3, low-grade dysplasia; 4.1, high-grade dysplasia; 4.2, carcinoma in situ; 4.3, suspicious of intramucosal carcinoma; 5.1, intramucosal carcinoma; and 5.2, submucosal carcinoma.
  • Adenomas with dysplasia (categories 3 and 4.1) or with carcinoma (categories 4.2, 4.3, 5.1 and 5.2) were analyzed separately.
  • On basis of their configuration, adenomas were classified into tubular, tubulovillous, villous, serrated, microtubular and combined phenotypes (i.e. other than tubulovillous).
  • RESULTS: The highest percentage of adenomas with carcinoma was found amongst villous adenomas (29.6%), followed by combined adenomas (27.8%).
  • Villous adenoma with carcinoma was the most frequent neoplasia at all ages; combined adenomas with carcinoma were more frequent among younger patients.
  • In elderly patients (> or = 60 years of age) the highest percentage of adenomas with carcinoma was recorded in villous adenomas (28.1%), followed by serrated adenomas (19.2%).
  • Villous adenomas and combined adenomas with carcinoma were more frequent in males.
  • CONCLUSION: The Vienna classification of colorectal adenomas seems to be influenced by parameters inherent to the patient such as age and sex and by the histological phenotype of the adenoma.
  • [MeSH-major] Adenoma / classification. Colorectal Neoplasms / classification

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  • (PMID = 16984592.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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92. Woodland JG: CDX-2 and MIB-1 expression in the colorectum: correlation with morphological features of adenomatous lesions. Br J Biomed Sci; 2006;63(2):68-73
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  • Transformation from normal to malignant mucosa is a multistep process involving specific gene mutations and is called the adenoma-carcinoma sequence.
  • Histologically, adenomas are of three types (tubular, tubulovillous and villous) and the extent of mucosal cellular abnormality of three grades (mild, moderate and severe).
  • This is a retrospective study of colorectal adenomas, and haematoxylin and eosin (H&E) and immunocytochemical staining for CDX-2 and MIB-1 (a cell proliferation marker) are performed on each case.
  • Comment is made on the morphological features (adenoma type and dysplasia severity) and the grade of CDX-2 and MIB-1 expression.
  • This study showed that dysplasia severity is linked to cellular proliferation (P=0.011) but adenoma type was not (P=0.54).
  • [MeSH-major] Adenoma / chemistry. Colorectal Neoplasms / chemistry. Homeodomain Proteins / analysis. Ki-67 Antigen / analysis. Neoplasm Proteins / analysis. Trans-Activators / analysis

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  • (PMID = 16871998.001).
  • [ISSN] 0967-4845
  • [Journal-full-title] British journal of biomedical science
  • [ISO-abbreviation] Br. J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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93. Hakeem A, Badrinath K: "Scoping-around" a sigmoidorectal intussusception: a pitfall of flexible sigmoidoscopy. BMJ Case Rep; 2009;2009

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  • An urgent flexible sigmoidoscopy (FS) showed an abnormal lesion within the anal canal and biopsy showed tubulovillous adenoma with low-grade dysplasia.

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  • (PMID = 21686998.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029465
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94. Rubio CA, Stemme S, Jaramillo E, Lindblom A: Hyperplastic polyposis coli syndrome and colorectal carcinoma. Endoscopy; 2006 Mar;38(3):266-70
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • Other colorectal lesions were found as follows: two patients each had one mixed polyp; there were 15 serrated adenomas in eight patients; and there were 30 tubular, tubulovillous, or villous adenomas in eight patients.
  • Of the four villous adenomas, three were associated with a CRC, but only one of the 15 serrated adenomas was associated with a CRC.
  • [MeSH-minor] Adenoma / pathology. Aged. Colonic Neoplasms / pathology. Female. Humans. Hyperplasia. Male. Middle Aged

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  • (PMID = 16528654.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 35
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95. Shinoda M, Makino A, Wada M, Kabeshima Y, Takahashi T, Kawakubo H, Shito M, Sugiura H, Omori T: Successful endoscopic submucosal dissection for mucosal cancer of the duodenum. Dig Endosc; 2010 Jan;22(1):49-52
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  • Histopathological examination of a biopsy specimen revealed features suggestive of a tubulovillous adenoma with severe atypia.

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  • (PMID = 20078665.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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96. Augoff K, Rabczynski J, Tabola R, Czapla L, Ratajczak K, Grabowski K: Immunohistochemical study of decorin expression in polyps and carcinomas of the colon. Med Sci Monit; 2008 Oct;14(10):CR530-5
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  • It was hypothesized that physiological expression of decorin may be associated with cellular senescence of the colorectal mucosa and that its down-regulation, promoting an increase in cellular proliferation, could participate in the progression of adenoma to adenocarcinoma.
  • MATERIAL/METHODS: Tissue samples were obtained from 41 patients with different types of colonic polyps (6 hyperplastic adenomas, 34 neoplastic adenomas, and 1 adenomatous polyp with focal carcinoma) and 12 patients with colon cancer.
  • RESULTS: Normal and hyperplastic tissues and the majority of tubular adenomas showed strong expression of decorin in the stroma.
  • Adenomas with a villous component showed moderate and very low decorin immunoreactivity.
  • The decrease in decorin reactivity in tubulo-villous adenomas was significant as compared with other polyps and controls.

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  • (PMID = 18830193.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / DCN protein, human; 0 / Decorin; 0 / Extracellular Matrix Proteins; 0 / Proteoglycans
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97. Fiducia G, Gandolfo L, Bosco V: [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases]. Chir Ital; 2008 Mar-Apr;60(2):227-32

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  • Local transanal excision as primary treatment of rectal and anal canal adenomas in selected patients is supported by the recent literature.
  • Histologically, 2 were tubular adenomas without atypia (12.5%), 3 were tubulo-villous adenomas with moderate atypia (18.75%), 8 were tubulo-villous adenomas (50%) with severe atypia, 2 were tubulo-villous adenomas with locally invasive foci of adenocarcinoma (12.5%), and 1 case was a pT1 cloacogenic carcinoma (6.25%).

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  • (PMID = 18689170.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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98. Perçinel S, Savaş B, Ensari A, Kuzu I, Kuzu MA, Bektaş M, Cetinkaya H, Kurşun N: Mucins in the colorectal neoplastic spectrum with reference to conventional and serrated adenomas. Turk J Gastroenterol; 2007 Dec;18(4):230-8
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  • [Title] Mucins in the colorectal neoplastic spectrum with reference to conventional and serrated adenomas.
  • BACKGROUND/AIMS: Alterations in expression of mucins and aberrant expression of various types of mucin genes were observed in colorectal adenomas and carcinomas, though their significance in neoplastic transformation of colorectal epithelium is yet to be determined.
  • The aim of this study was to determine expression of MUC1, MUC2, MUC5AC, and MUC6 through conventional adenoma-carcinoma sequence and polyps involved in the "serrated" pathway of the colorectum using tissue array technique.
  • METHODS: In this study, a total of 172 cases including 100 colorectal polyps [8 hyperplastic polyps, 10 sessile serrated adenomas, 19 tubular, 37 tubulovillous, and 26 villous adenomas], 16 adenomas with intramucosal carcinoma, 28 conventional colorectal cancers, and 28 normal mucosae were examined.
  • Sessile serrated adenomas exhibited the highest MUC5AC expression while adenomatous polyps showed an increase in MUC5AC expression in parallel with neoplastic progression (p<0.001).
  • Hyperplastic polyps seemed to lie between normal mucosa and sessile serrated adenomas in terms of mucin expression, suggesting that they are morphologically and histogenetically linked.
  • CONCLUSIONS: Upregulation of MUC1 and MUC6 through the adenoma-carcinoma sequence together with downregulation of MUC2 and MUC5AC at the neoplastic end of the spectrum seem to follow the steps of malignant transformation.
  • [MeSH-major] Adenoma / metabolism. Colonic Polyps / metabolism. Colorectal Neoplasms / metabolism. Mucins / metabolism

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  • (PMID = 18080919.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Mucins
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99. Seike K, Koda K, Oda K, Kosugi C, Shimizu K, Nishimura M, Shioiri M, Takano S, Ishikura H, Miyazaki M: Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasms. Am J Gastroenterol; 2006 Jun;101(6):1362-9
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  • The correlation between ACF grading and the prevalence of colonic advanced neoplasm, any adenoma>or=1 cm in size and/or with villous or tubulovillous morphology, and/or with high-grade dysplasia or invasive cancer, was assessed.

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  • (PMID = 16771962.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; T42P99266K / Methylene Blue
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100. Ramos O Jr, Boguszewski CL, Teixeira S, De Bem R, Parolim B, Prolla JC: Performance of computed tomographic colonography for the screening of colorectal polyp in acromegalic patients: a prospective study. Arq Gastroenterol; 2009 Apr-Jun;46(2):90-6
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  • The histological analysis of resected lesions revealed 12 tubular adenomas, 6 hyperplastic polyps and 1 colonic tubulo-villous adenoma with an adenocarcinoma focus.

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  • [CommentIn] Arq Gastroenterol. 2009 Apr-Jun;46(2):85-6 [19578605.001]
  • (PMID = 19578607.001).
  • [ISSN] 1678-4219
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
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