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1. Greco S, Cassinotti A, Massari A, Bossi I, Trabucchi E, Bianchi Porro G: Isolated ampullary adenoma causing biliary obstruction. J Gastrointestin Liver Dis; 2008 Sep;17(3):329-32
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  • [Title] Isolated ampullary adenoma causing biliary obstruction.
  • This is an interesting case of an isolated ampullary adenoma causing biliary obstruction that required surgical excision.
  • We describe a patient who presented with a six month history of recurrent attacks of typical biliary pain radiating from the right upper quadrant of the abdomen to the back, nausea and vomiting, which we attributed to a large pedunculated tubulovillous adenoma.
  • Abdominal ultrasound and endoscopic ultrasonography provided useful information in the diagnostic assessment of ampullary adenoma.
  • Sporadic duodenal adenomas are an increasingly recognized condition in those with familial adenomatous polyposis syndromes as well as sporadic cases.
  • [MeSH-major] Adenoma / complications. Ampulla of Vater. Cholestasis / etiology. Common Bile Duct Neoplasms / complications

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  • (PMID = 18836629.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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2. Rogers AM, Capen J, Galka E, Cooney RN: Tubulovillous adenoma with atypia found at gastrojejunal anastomosis 8 years after gastric bypass for morbid obesity. Surg Obes Relat Dis; 2007 Sep-Oct;3(5):559-60
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  • [Title] Tubulovillous adenoma with atypia found at gastrojejunal anastomosis 8 years after gastric bypass for morbid obesity.
  • [MeSH-major] Adenoma, Villous / etiology. Anastomosis, Roux-en-Y / adverse effects. Gastric Bypass / adverse effects. Gastrointestinal Neoplasms / etiology. Obesity, Morbid / surgery

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  • (PMID = 17686664.001).
  • [ISSN] 1550-7289
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Kakar S, Deng G, Cun L, Sahai V, Kim YS: CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. Hum Pathol; 2008 Jan;39(1):30-6
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  • [Title] CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component.
  • We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS mutations and methylation at hMLH1, p16, HIC1, RASSF2, MGMT, MINT1, and MINT31.
  • CIMP-positive status (methylation at 3 or more loci) was observed in 44% tubulovillous/villous adenomas compared with 8 (27%) of 30 tubular adenomas (P = .08).
  • Tubulovillous/villous adenomas showed significantly higher methylation than tubular adenomas at MGMT (87% vs 37%, P < .01) and RASSF2 (94% vs 70%, P = .02).
  • There was no significant difference in methylation of HIC1, MINT1, MINT31, and p16. hMLH1 methylation was absent in all tubulovillous/villous adenomas and seen in only 2 (7%) tubular adenomas.
  • CIMP-positive status correlated with large size, right-sided location, and amount of villous component in tubulovillous/villous adenomas.
  • BRAF V600E mutation was not observed in any tubular adenoma or tubulovillous/villous adenoma.
  • KRAS mutations were seen in 9% of tubulovillous/villous adenomas and 10% of tubular adenomas.
  • In conclusion, CIMP-positive phenotype is common in tubulovillous/villous adenomas and increases with large size, right-sided location, and amount of villous component.
  • Methylation of MGMT and RASSF2 increases during the progression from tubular adenoma to tubulovillous/villous adenoma.
  • BRAF mutations are absent in tubulovillous/villous adenomas.
  • [MeSH-major] Adenoma, Villous / genetics. Adenoma, Villous / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. CpG Islands. DNA Methylation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. ras Proteins / genetics

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  • (PMID = 17950780.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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4. Senapati S, Ho SB, Sharma P, Das S, Chakraborty S, Kaur S, Niehans G, Batra SK: Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon. J Clin Pathol; 2010 Aug;63(8):702-7
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  • Similarly, MUC17 expression was decreased in hyperplastic polyps (p=0.0003), tubular and tubulovillous adenomas (p<0.0001) and colon cancers (p<0.0001).

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  • (PMID = 20702471.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA133774-04; United States / NCI NIH HHS / CA / R01 CA078590-13; United States / NCI NIH HHS / CA / U01 CA111294; United States / NIDDK NIH HHS / DK / R24 DK080506; United States / NCI NIH HHS / CA / CA131944-04; United States / NCI NIH HHS / CA / CA133774; United States / NCI NIH HHS / CA / R01 CA078590; United States / NCI NIH HHS / CA / R01 CA131944; United States / NCI NIH HHS / CA / CA78590; United States / NCI NIH HHS / CA / CA133774-04; United States / NCI NIH HHS / CA / R01 CA133774; United States / NIDDK NIH HHS / DK / DK080506; United States / NCI NIH HHS / CA / CA131944; United States / NCI NIH HHS / CA / R01 CA131944-04; United States / NCI NIH HHS / CA / CA111294
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MUC17 protein, human; 0 / Mucins
  • [Other-IDs] NLM/ NIHMS254309; NLM/ PMC2997570
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5. Lo SH, Law WL: Laparoscopic colorectal resection for polyps not suitable for colonoscopic removal. Surg Endosc; 2005 Sep;19(9):1252-5
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  • The histopathology of colorectal polyps showed tubular (n = 12), tubulovillous (n = 13), and villous adenoma (n = 12); mixed adenomatous/hyperolastic polyps (n = 2); inflammatory polyp (n = 1); and colonic lipoma (n = 1).

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  • (PMID = 16132333.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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6. Mittal R, Perakath B, Chase S, Jesudason MR, Nayak S: Transanal excision of anorectal lesions--a single centre experience. Trop Gastroenterol; 2010 Jan-Mar;31(1):65-8
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  • Tubulovillous adenomas and hyperplastic polyps were the commonest benign lesions.

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  • (PMID = 20860237.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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7. Koebrugge B, Bosscha K, Jager G, Ernst M: Accuracy of transrectal ultrasonography in staging rectal tumors that are clinically eligible for transanal endoscopic microsurgery. J Clin Ultrasound; 2010 Jun;38(5):250-3
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  • Postoperative pathologic findings confirmed the preoperative TRUS findings in 29 patients; in 1 patient, a T3 staged tumor was an overstaged lesion biopsied as a tubulovillous adenoma.

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  • (PMID = 20186761.001).
  • [ISSN] 1097-0096
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Velayos FS, Allen BA, Conrad PG, Gum J Jr, Kakar S, Chung DC, Truta B, Sleisenger MH, Kim YS, Terdiman JP: Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines. Am J Gastroenterol; 2005 May;100(5):1143-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines.
  • BACKGROUND AND AIM: Screening adenomas for microsatellite instability (MSI) in patients younger than 40 yr of age has been recommended by the Bethesda Guidelines as a means of identifying patients at risk for hereditary nonpolyposis colorectal cancer (HNPCC).
  • We sought to determine the rate of MSI in adenomas removed from individuals under 40 yr of age over a 5-yr period in a university general gastroenterology practice.
  • Adenomas were tested for MSI using the BAT26 and BAT40 microsatellite markers, and expression of the MSH2 and MLH1 proteins was assessed by immunostaining.
  • RESULTS: A total of 34 patients had 46 adenomas removed endoscopically.
  • A total of 28 of 46 adenomas (61%) were distal to the splenic flexure.
  • Five polyps (11%) were tubulovillous adenomas, and the remainder were tubular adenomas.
  • None of the polyps were serrated adenomas and none demonstrated high-grade dysplasia.
  • Among the 40 adenomas available for testing, none demonstrated MSI using either BAT26 (0/40) or BAT40 (0/21), nor did any of the polyps tested demonstrate loss of either MSH2 or MLH1 expression (0/16).
  • CONCLUSION: Screening adenomas from patients younger than 40 yr of age for MSI was ineffective in identifying potentially new cases of HNPCC.
  • [MeSH-major] Adenoma / genetics. Chromosomal Instability / genetics. Colonic Neoplasms / genetics. Microsatellite Repeats / genetics. Rectal Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma, Villous / genetics. Adenoma, Villous / pathology. Adolescent. Adult. Base Pair Mismatch / genetics. Carrier Proteins. Colonic Polyps / genetics. Colonic Polyps / pathology. Colonoscopy. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. DNA-Binding Proteins / genetics. Female. Genetic Predisposition to Disease / genetics. Genetic Testing. Humans. Intestinal Polyps / genetics. Intestinal Polyps / pathology. Male. MutS Homolog 2 Protein. Neoplasm Proteins / genetics. Nuclear Proteins. Proctoscopy. Proto-Oncogene Proteins / genetics. Risk Factors

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  • [CommentIn] Am J Gastroenterol. 2006 Jan;101(1):204 [16405562.001]
  • [CommentIn] Am J Gastroenterol. 2005 May;100(5):1150-3 [15842592.001]
  • (PMID = 15842591.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / MLH1 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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9. Huang Y, Gong W, Su B, Zhi F, Liu S, Bai Y, Jiang B: Recurrence and surveillance of colorectal adenoma after polypectomy in a southern Chinese population. J Gastroenterol; 2010 Aug;45(8):838-45
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  • [Title] Recurrence and surveillance of colorectal adenoma after polypectomy in a southern Chinese population.
  • BACKGROUND AND AIM: Repeat colonoscopy is often performed within a short time after polypectomy due to the fear that colorectal adenomas were missed during the initial colonoscopy or that new adenomas have developed.
  • The aim of this study was to estimate the actual recurrence rate of adenoma and its association with the length of the surveillance interval after polypectomy in a southern Chinese population.
  • The recurrence rates of adenoma and advanced adenoma and surveillance intervals after polypectomy were identified based on the features of adenomas detected on initial colonoscopy.
  • RESULTS: The recurrence rates of advanced adenoma in patients with non-advanced adenoma on the initial colonoscopy were 0.9, 3.9, 5.8, and 29.2% during surveillance intervals of 1-3, 3-5, 5-10, and 10-20 years post-initial colonoscopy; for patients with advanced adenoma on the initial colonoscopy, the recurrence rates were 3.8, 13.1, 34.7, and 52.0% during the same surveillance intervals, respectively.
  • Older age (p < 0.05 for trend) and male sex [hazard ratio (HR) 2.11, 95% confidence interval (CI) 1.27-3.53] were significantly associated with recurrence for advanced adenoma, as were the size and number of baseline adenoma (p < 0.05 for trend), tubulovillous, villous adenoma (HR 2.57, 95% CI 1.24-5.32), and high-grade dysplasia (HR 1.61, 95% CI 1.07-2.42).
  • When 5% of patients had recurring advanced adenoma, the surveillance interval was estimated to be 6.9 (95% CI 6.3-12.2) years in the low-risk group and 3.0 (95% CI 2.7-3.2) years in the high-risk group.
  • CONCLUSIONS: Among our patient group, the recurrence of advanced adenoma after polypectomy increased with the length of the surveillance interval.
  • Based on our results, a 3-year follow-up of patients after polypectomy could be effective in preventing the recurrence of advanced adenoma in high-risk patients.
  • [MeSH-major] Adenoma / diagnosis. Colonic Polyps / surgery. Colonoscopy / methods. Colorectal Neoplasms / diagnosis

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  • (PMID = 20336471.001).
  • [ISSN] 1435-5922
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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10. Armah HB, Krasinskas AM, Parwani AV: Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case. Diagn Pathol; 2007;2:29
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  • [Title] Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case.
  • We present the case of a 39-year-old male with a tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty to enlarge a post-chemoradiation-induced shrunken bladder.
  • Cystoscopy revealed a papillary tumor at the site of ileovesical anastomosis, and transurethral resection was performed.
  • Histologic examination revealed a tubular adenoma with high-grade dysplasia.
  • There are only two previous reports of tubulovillous adenoma in ileal segment after ileocystoplasty, both without high-grade dysplasia.
  • Our observation supports the hypothesis that an ileal neobladder may undergo all the morphologic and molecular changes observed in the development of gastrointestinal adenocarcinoma.

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  • (PMID = 17697327.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1995190
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11. Regula J, Rupinski M, Kraszewska E, Polkowski M, Pachlewski J, Orlowska J, Nowacki MP, Butruk E: Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med; 2006 Nov 2;355(18):1863-72
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  • We defined advanced neoplasia as cancer or adenoma that was at least 10 mm in diameter, had high-grade dysplasia, or had villous or tubulovillous histologic characteristics, or any combination thereof.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis

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  • [Copyright] Copyright 2006 Massachusetts Medical Society.
  • [CommentIn] Nat Clin Pract Oncol. 2007 Jul;4(7):392-3 [17519918.001]
  • [CommentIn] Gastroenterology. 2007 Jun;132(7):2605-6 [17570233.001]
  • [CommentIn] N Engl J Med. 2007 Feb 8;356(6):632; author reply 633-4 [17287485.001]
  • [CommentIn] N Engl J Med. 2007 Feb 8;356(6):632-3; author reply 633-4 [17290510.001]
  • [CommentIn] N Engl J Med. 2007 Feb 8;356(6):633; author reply 633-4 [17288050.001]
  • (PMID = 17079760.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
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12. Pantanowitz L: Colonic adenoma with squamous metaplasia. Int J Surg Pathol; 2009 Aug;17(4):340-2
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  • [Title] Colonic adenoma with squamous metaplasia.
  • Squamous metaplasia arising within colon adenomas is a rare occurrence, with a 0.4% incidence noted predominantly in elderly males.
  • A case of squamous metaplasia arising in a tubulovillous adenoma of the cecum, associated with adenocarcinoma, is described.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology

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  • (PMID = 18701516.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / beta Catenin
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13. Tagaya N, Kasama K, Suzuki N, Taketsuka S, Horie K, Kubota K: Simultaneous laparoscopic treatment for diseases of the gallbladder, stomach, and colon. Surg Laparosc Endosc Percutan Tech; 2005 Jun;15(3):169-71
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  • The histopathologic diagnoses were chronic cholecystitis, leiomyoma of the stomach, and tubulovillous adenoma with severe dysplasia of the colon.
  • [MeSH-major] Adenoma, Villous / surgery. Cholecystolithiasis / epidemiology. Cholecystolithiasis / surgery. Colonic Neoplasms / surgery. Laparoscopy. Leiomyoma / surgery. Stomach Neoplasms / surgery

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  • (PMID = 15956904.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Kahveci A, Ari E, Arikan H, Koc M, Tuglular S, Ozener C: Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient. Hemodial Int; 2010 Jan;14(1):91-3
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  • [Title] Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient.
  • Abstract We report the case of a 54-year-old hemodialysis patient who presented with recurrent fever due to Streptococcus bovis bacteremia related to colonic tubulovillous adenoma.
  • In this paper, we discussed the relation between S. bovis bacteremia, colonic adenomas, and hemodialysis.
  • [MeSH-major] Adenoma / microbiology. Bacteremia / etiology. Colonic Neoplasms / microbiology. Kidney Failure, Chronic / therapy. Renal Dialysis / adverse effects. Streptococcal Infections / pathology. Streptococcus bovis / isolation & purification

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  • (PMID = 19758303.001).
  • [ISSN] 1542-4758
  • [Journal-full-title] Hemodialysis international. International Symposium on Home Hemodialysis
  • [ISO-abbreviation] Hemodial Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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15. Misra SP, Dwivedi M: Colonoscopy and colonoscopic polypectomy using side-viewing endoscope: a useful, effective and safe procedure. Dig Dis Sci; 2008 May;53(5):1285-8
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  • All ten polyps removed from children were juvenile polyps, while two of the three removed from adults were tubular adenomas and one was a tubulovillous adenoma.

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  • (PMID = 17952594.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Jotautas V, Strupas K, Poskus E, Seinin D: [Treatment of rectal tumors with transanal endoscopic microsurgery]. Medicina (Kaunas); 2005;41(6):470-6
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  • MATERIALS AND METHODS: The patients who had rectal adenomas and low-risk T1 carcinomas of good or moderate differentiation, with no lymphatic and vascular invasion were selected for surgery.
  • Overall 25 (52.1%) carcinomas and 23 (47.9%) adenomas were removed.
  • Twenty-six patients were followed up for 3-17 months after operation: 17 after removal of cancer and 9 after removal of adenoma.
  • One (2.1%) recurrence of a tubulovillous adenoma was diagnosed.
  • CONCLUSIONS: Initial results of transanal endoscopic microsurgery obtained while treating rectal adenomas and low-risk T1 cancers are promising.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Proctoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenoma, Villous / pathology. Adenoma, Villous / radiotherapy. Adenoma, Villous / surgery. Adult. Aged. Aged, 80 and over. Biopsy. Combined Modality Therapy. Data Interpretation, Statistical. Female. Humans. Male. Microsurgery. Middle Aged. Minimally Invasive Surgical Procedures. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Rectum / pathology. Treatment Outcome

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  • (PMID = 15998984.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
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17. Mizoshita T, Tsukamoto T, Inada KI, Hirano N, Tajika M, Nakamura T, Ban H, Tatematsu M: Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. Histol Histopathol; 2007 03;22(3):251-60
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  • [Title] Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon.
  • MUC2 expression demonstrated a significant decrease from tubular/tubulovillous adenomas with moderate atypia, through intramucosal carcinomas, to cancers with submucosal invasion (P<0.0001).
  • Expression of MUC5AC also decreased significantly with progression according to the tubular/tubulovillous adenoma-carcinoma sequence, carcinomas with villous adenomatous components having a higher level compared with their tubular adenomatous counterparts, suggesting differences in the pathway of malignant transformation.
  • Cdx2 nuclear expression was maintained in all of the adenomas and early carcinomas examined.
  • CONCLUSIONS: Our data suggest that the reduction of MUC2 expression may be associated with the occurrence and progression of colorectal carcinomas in both adenoma-carcinoma sequence pathway and de novo carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Villous / metabolism. Colorectal Neoplasms / metabolism. Mucins / metabolism

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  • (PMID = 17163399.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Microfilament Proteins; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins; 0 / villin
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18. John R, El-Rouby NM, Tomasetto C, Rio MC, Karam SM: Expression of TFF3 during multistep colon carcinogenesis. Histol Histopathol; 2007 07;22(7):743-51
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  • Colonic tissues representing colitis, adenomatous polyposis, tubulovillous adenoma, and mucoid/adeno-carcinomas were processed for immunohistochemistry using an antibody specific for human TFF3.
  • The data showed marked down-regulation of TFF3 expression in adenomatous polyposis, then TFF3 expression returns to about control level during adenoma and remains high during mucoid- and adeno-carcinomas.
  • [MeSH-major] Adenocarcinoma, Mucinous / chemistry. Adenoma, Villous / chemistry. Adenomatous Polyposis Coli / chemistry. Colitis / metabolism. Colonic Neoplasms / chemistry. Peptides / analysis

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  • (PMID = 17455148.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Peptides; 0 / Proliferating Cell Nuclear Antigen; 0 / TFF3 protein, human; 0 / Trefoil Factor-3
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19. Cohen RJ, Shannon BA: Tubulovillous adenoma of the prostatic urethra: a rare and usually indolent lesion distinct from prostatic adenocarcinoma. Pathology; 2007 Oct;39(5):522-4
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  • [Title] Tubulovillous adenoma of the prostatic urethra: a rare and usually indolent lesion distinct from prostatic adenocarcinoma.
  • [MeSH-major] Adenoma / pathology. Diverticulum / pathology. Prostatic Neoplasms / pathology. Urethral Neoplasms / pathology

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  • (PMID = 17886106.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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20. Kim JH, Choi JW, Seo YS, Lee BJ, Yeon JE, Kim JS, Byun KS, Bak YT, Kim I, Park JJ: Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum. World J Gastroenterol; 2007 Jun 21;13(23):3262-4
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  • [Title] Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum.
  • Moreover, duodenal tubulovillous adenomas are more uncommon lesions.
  • The microscopic structure of tubulovillous adenoma has frond-like projection of mucosa with branching papillary structure and generally upward growth into the lumen.
  • We describe a 72-year-old man who showed aduodenal tubulovillous adenoma with unusual inverted cystic growth pattern.
  • Interestingly, this tubulovillous adenomatous lesion was interrupted by gastric metaplasia in the deep portion of the cyst and was closely surrounded by Brunner's glands.
  • Therefore, these findings argued that this adenoma arises from Brunner's glands through gastric metaplasia.
  • This is the first case of inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum with gastric metaplasia.
  • [MeSH-major] Adenoma / pathology. Brunner Glands / pathology. Cysts / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 17589910.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436617
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21. Kirimlioglu H, Kirimlioglu V, Yilmaz S, Sagir V, Coban S, Turkmen E, Hilmioglu F: Role of matrix metalloproteinase-7 in colorectal adenomas. Dig Dis Sci; 2006 Nov;51(11):2068-72
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  • [Title] Role of matrix metalloproteinase-7 in colorectal adenomas.
  • They are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas.
  • In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of colonic adenomas.
  • Although MMP-7 has already been shown to be overexpressed in various types of colonic adenomas, tubular versus villous adenomas had not been further seperated to date.
  • Seventy-six patients had either normal mucosa (n=15) or tubular (n=32), tubulovillous (n=16), or villous (n=13) colonic adenoma.
  • Each adenoma was graded according to the percentage of strongly stained areas in the adenoma as G0, G1, G2, or G3.
  • Sixty-nine percent of villous adenomas showed grade 3 staining of MMP-7, versus none of the tubular adenomas.
  • G0 and G1 staining was not detected in the villous adenomas.
  • The results of the study show that the degrees of overexpression of the three subtypes of colonic adenomas were statistically significantly different.
  • In conclusion, MMP-7 overexpression is thought to be an early event in the adenoma-carcinoma pathway.
  • [MeSH-major] Adenoma / enzymology. Colorectal Neoplasms / enzymology. Matrix Metalloproteinase 7 / physiology
  • [MeSH-minor] Adenoma, Villous / enzymology. Adenoma, Villous / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies

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  • (PMID = 17009118.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
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22. Zhang WW, Ren BJ, Tong HS, Zhang YL, Jiang P: [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 May;9(3):250-2
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  • [Title] [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases].
  • OBJECTIVE: To explore the endoscopic and histopathological morphology of large intestinal serrated adenomas (SA).
  • RESULTS: Forty-seven of the 71 serrated adenomas were protruded (sessile 23, semipedunculated 5, pedunculated 23) and 24 were superficial (flat 16, laterally spreading 8).
  • Histopathologically, SA contained tubular glands in 53, tubulovillous glands in 9 and villous glands in 9 cases.
  • Most IV and III L pit SAs presented villous glands (64%) and tubular glands (68%), respectively.
  • [MeSH-major] Adenoma / pathology. Colonoscopy. Colorectal Neoplasms / pathology

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  • (PMID = 16721690.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
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23. Antillon MR, Bartalos CR, Miller ML, Diaz-Arias AA, Ibdah JA, Marshall JB: En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video). Gastrointest Endosc; 2008 Feb;67(2):332-7
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  • [Title] En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video).
  • PATIENTS: A 53-year-old patient, with a 14-cm tubulovillous adenoma of the rectum, which, at its maximal extent, involved two thirds of the circumference of the rectum.
  • [MeSH-major] Adenoma / surgery. Anal Canal / pathology. Electrocoagulation / methods. Rectal Neoplasms / surgery. Thoracoscopy / methods

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  • (PMID = 18226698.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Sofic A, Beslic S, Kocijancic I, Sehovic N: CT colonography in detection of colorectal carcinoma. Radiol Oncol; 2010 Mar;44(1):19-23
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  • Among polyps pato-histology revealed 34 adenomas, 3 tubulovillous adenomas and 2 lipomas, among tumours there were 55 adenocarcinomas and 1 lymphoma.

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  • (PMID = 22933886.001).
  • [ISSN] 1318-2099
  • [Journal-full-title] Radiology and oncology
  • [ISO-abbreviation] Radiol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovenia
  • [Other-IDs] NLM/ PMC3423676
  • [Keywords] NOTNLM ; CT colonography / barium enema / colonoscopy / colorectal carcinoma / colorectal polyp
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25. Nguyen BD: PET imaging of concomitant colonic hyperplastic polyp and tubulovillous adenoma. Clin Nucl Med; 2005 Jan;30(1):48-50
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  • [Title] PET imaging of concomitant colonic hyperplastic polyp and tubulovillous adenoma.
  • [MeSH-major] Adenoma, Villous / radionuclide imaging. Colon / pathology. Colon / radionuclide imaging. Colonic Neoplasms / radionuclide imaging. Colonic Polyps / radionuclide imaging. Fluorodeoxyglucose F18

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  • (PMID = 15604975.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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26. Freeman HJ, Webber DL, Meneghetti AT: An appendiceal neoplastic lesion: case report and implications for colonoscopic screening and surveillance. Can J Gastroenterol; 2009 May;23(5):379-81
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  • A 65-year-old man with a history of previously resected colonic adenomas had an apparent cecal lesion detected during colonoscopy.
  • The polyp proved to be a tubulovillous adenoma with high-grade dysplasia involving most of the body of the appendix along with the base of the cecum.
  • [MeSH-major] Adenoma, Villous / diagnosis. Appendectomy / methods. Appendiceal Neoplasms / diagnosis. Colonoscopy / methods

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  • (PMID = 19440570.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2706752
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27. Lakis S, Papamitsou T, Panagiotopoulou C, Kotakidou R, Kotoula V: AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas. World J Gastroenterol; 2010 May 28;16(20):2476-83
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  • [Title] AMACR is associated with advanced pathologic risk factors in sporadic colorectal adenomas.
  • AIM: To analyze alpha-methylacyl CoA racemase (AMACR) expression in relation to various dysplasia phenotypes and clinicopathological parameters of sporadic colorectal adenomas.
  • METHODS: Fifty-five cases of sporadic colorectal adenomas were categorized according to the Vienna classification for Gastrointestinal Neoplasia.
  • AMACR expression was evaluated by immunohistochemistry and statistical analysis was performed to investigate possible associations with various clinicopathologic parameters of adenomas i.e. gender, age, localization, grade of dysplasia, size and configuration.
  • Adenomas ranged in size between 0.5 and 30 cm (mean 2 +/- 1.3 cm), including 18 tubular, 16 villous, 20 mixed or tubulovillous, and 1 giant sessile villous adenoma.
  • Most adenomas exhibiting high grade dysplasia with in situ carcinoma-like areas stained positive for AMACR (15/17 or 88.2%) as compared to adenomas with high grade dysplasia which contained severe dysplasia-like foci (6/15 or 40%), (P = 0.005).
  • In AMACR positive adenomas featuring severe dysplasia-like or in situ carcinoma-like areas, AMACR staining was not necessarily observed in the in situ component.
  • Positivity in intra-lesion of mild, moderate or severe dysplasia-like foci was more often encountered in adenomas harboring in situ, intramucosal or infiltrative carcinoma [21/33 (63.6%) vs 9/40 (22.5%), P < 0.001].
  • Strong AMACR expression was found in 11 out of 17 villous adenomas, but in only 1 out of 18 tubular lesions (P = 0.005).
  • Overall, AMACR expression was associated with the grade of dysplasia, as well as with the size and configuration of adenomas, i.e. the consensus risk factors applied to colorectal adenoma patient surveillance.
  • CONCLUSION: It may be worthy to further evaluate the possible use of AMACR as an additional risk factor for the assessment of colorectal adenoma patients.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / pathology. Racemases and Epimerases / metabolism

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  • (PMID = 20503447.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
  • [Other-IDs] NLM/ PMC2877177
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28. Bansal A, Liu X, McGregor DH, Singh V, Hall S: Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series. Am J Med Sci; 2010 Oct;340(4):296-300
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  • [Title] Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series.
  • Although EGFR is described to be overexpressed in adenomas, to the authors' knowledge, its relationship with advanced features in adenomas and as a marker for adenoma progression has not been studied.
  • Subsequently, a validation group of 95 adenomas from 16 patients were graded semiquantitatively for EGFR staining.
  • Size and villous features of the adenomas were evaluated by 2 independent pathologists and compared with EGFR expression.
  • To be classified as advanced, adenomas needed to be greater than 1 cm and fulfill 1 of the 2 criteria-villous component >20% to 25% or presence of high-grade dysplasia.
  • RESULTS: In the index case, the large 5.5 cm tubulovillous adenoma had EGFR positivity in all of its neoplastic cells, whereas another 2 cm tubular adenoma with focal villous features had 30% EGFR positivity.
  • In 95 adenomas from 16 additional patients, there was a significant correlation of EGFR positivity with adenoma size ≥1 cm and villous features (all P < 0.001).
  • The odds of EGFR expression in advanced adenomas were 17.3 times higher than nonadvanced adenomas (P < 0.001).
  • CONCLUSIONS: These findings suggest that EGFR overexpression is associated with advanced colorectal adenomas.
  • Further larger studies are needed to explore EGFR expression as a biomarker for adenoma progression.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Receptor, Epidermal Growth Factor / metabolism

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  • (PMID = 20622650.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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29. Otake S, Takeda H, Suzuki Y, Fukui T, Watanabe S, Ishihama K, Saito T, Togashi H, Nakamura T, Matsuzawa Y, Kawata S: Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res; 2005 May 15;11(10):3642-6
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  • [Title] Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance.
  • To investigate whether visceral fat accumulation contributes to colorectal carcinogenesis, we examined its accumulation and the levels of the adipose tissue-derived hormone adiponectin in Japanese patients with colorectal adenoma.
  • EXPERIMENTAL DESIGN: Fifty-one consecutive Japanese patients ages >/=40 years and with colorectal adenoma were subjected to measurement of visceral fat area by computed tomography scanning and plasma adiponectin concentration.
  • RESULTS: The patients with colorectal adenoma showed significantly more visceral fat area and significantly less plasma adiponectin concentration in comparison with the controls [odds ratio (OR), 2.19; 95% confidence interval (95% CI), 1.47-3.28; P < 0.001 and OR, 0.24; 95% CI, 0.14-0.41; P < 0.001, respectively] by logistic regression analysis.
  • HOMA-IR index was also associated with colorectal adenoma (OR 2.60; 95% CI, 1.20-5.64; P = 0.040).
  • Visceral fat area and adiponectin were associated with adenoma number (1, 2, >/= 3), the size of the largest adenoma (<10 and >/=10 mm), and adenoma histology (tubular and tubulovillous/villous).
  • CONCLUSIONS: These results suggest an association of visceral fat accumulation and decreased plasma adiponectin concentration with colorectal adenoma in Japanese patients.
  • [MeSH-major] Adenoma / physiopathology. Adipose Tissue. Body Composition. Colorectal Neoplasms / physiopathology. Insulin Resistance. Intercellular Signaling Peptides and Proteins / blood

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  • (PMID = 15897559.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Intercellular Signaling Peptides and Proteins
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30. Shinoda M, Makino A, Wada M, Kabeshima Y, Takahashi T, Kawakubo H, Shito M, Sugiura H, Omori T: Successful endoscopic submucosal dissection for mucosal cancer of the duodenum. Dig Endosc; 2010 Jan;22(1):49-52
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  • Histopathological examination of a biopsy specimen revealed features suggestive of a tubulovillous adenoma with severe atypia.

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  • (PMID = 20078665.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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31. Arslan N, Dehdashti F, Siegel BA: FDG uptake in colonic villous adenomas. Ann Nucl Med; 2005 Jun;19(4):331-4
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  • [Title] FDG uptake in colonic villous adenomas.
  • Colonic adenomas constitute 70-80% of all colorectal polyps, and their clinical significance relates primarily to their relationship with colorectal cancer.
  • The purpose of this study was to investigate the rate of FDG-PET positivity within colonic villous adenomas.
  • A pathology database search was performed to identify all patients diagnosed with colonic villous adenoma between June 1, 1996 and December 1, 2000.
  • Patients with a pathologic diagnosis of colonic villous adenoma and who also had a FDG-PET study up to 1 month before colonoscopy were included in this study.
  • Of more than 4,000 patients, six patients were diagnosed with colonic adenoma on subsequent colonoscopy following FDG-PET study.
  • Based on the pathological findings, these 6 patients had a total of 2 villous and 9 tubulovillous adenomas.
  • Five of the 6 patients showed foci of increased FDG uptake in the region of the colon that corresponded to the villous adenoma(s) detected on colonoscopy, which accounted for a true-positive rate of 83.3% (5/6 subjects).
  • Focal lesions in the colon seen on FDG-PET examinations need to be investigated further, even though some of these will prove to be villous adenomas rather than colorectal carcinomas.
  • [MeSH-major] Adenoma, Villous / radionuclide imaging. Colorectal Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18 / pharmacokinetics. Positron-Emission Tomography / methods

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  • (PMID = 16097645.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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32. Li J, Lv YM, Jin Z, Cui RL: [The effects of sulindac on the pathology of colorectal remnant polyps of familial adenomatous polyposis (FAP) patients]. Beijing Da Xue Xue Bao; 2005 Aug 18;37(4):371-3
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  • OBJECTIVE: To evaluate the long-term effectiveness of sulindac on the pathology of colorectal adenomas of familial adenomatous polyposis (FAP) patients.
  • RESULTS: Before the study, 90.8% of adenoma biopsies were tubular, while 9.2% was tubulovillous adenoma.
  • After sulindac treatment, 99.8% of adenoma biopsies were tubular, while 0.2% tubulovillous adenoma.
  • Minor flat elevation and erythema were found during the treatment, in which approximately 65% was adenoma.
  • CONCLUSION: Long-term use of sulindac seems to be effective in reducing dysplasia grade and tubulovillous adenoma of retained colorectal adenoma of FAP patients.
  • Minor flat elevation and erythema may be the lesions appearing during the regression of adenoma.

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  • (PMID = 16086054.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 184SNS8VUH / Sulindac
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33. Parfitt JR, Driman DK: Survivin and hedgehog protein expression in serrated colorectal polyps: an immunohistochemical study. Hum Pathol; 2007 May;38(5):710-7
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  • Sessile serrated adenomas and traditional serrated adenomas are pathogenetically related to inhibition of apoptosis.
  • This study compares survivin and hedgehog protein expression in serrated polyps and tubulovillous adenomas.
  • Biopsies of sessile serrated adenomas (48) and traditional serrated adenomas (10) diagnosed during 2005 were retrieved from our files.
  • Biopsies of normal mucosa (10), hyperplastic polyps (14), and tubulovillous adenomas (22) were used for comparison.
  • Traditional serrated adenomas were also compared to sessile serrated adenomas with foci of cytological dysplasia (11 cases) with respect to MLH1 and p53 expression.
  • Sessile serrated adenomas showed high-grade nuclear and cytoplasmic expression of survivin at the bottom of crypts more frequently than tubulovillous adenomas (60% versus 18%, P = .001 [nuclear]; 54% versus 18%, P = .005 [cytoplasm]), the latter showing a top-heavy pattern of staining.
  • Survivin expression in hyperplastic polyps was similar to sessile serrated adenomas, being bottom-heavy, whereas traditional serrated adenomas showed diffuse staining throughout crypts.
  • Although traditional serrated adenomas showed high-grade expression of sonic hedgehog more frequently than tubulovillous adenomas (90% versus 18%; P < .001), sonic hedgehog, patched, and smoothened expression was low grade among normal mucosa, hyperplastic polyps, and sessile serrated adenomas.
  • All cytological dysplasias showed increased p53 expression within dysplastic foci, and MLH1 was also lost within dysplastic foci in 4 cases; traditional serrated adenomas showed intact MLH1 expression and minimal p53 expression throughout.
  • Survivin expression is localized to the bottom of crypts in sessile serrated adenomas and hyperplastic polyps, whereas tubulovillous adenomas show top-heavy expression.
  • Traditional serrated adenomas express survivin throughout crypts, suggesting intersection between the serrated and conventional adenoma-cancer pathways.
  • Sonic hedgehog up-regulation is characteristic of traditional serrated adenomas, distinguishing this entity from other colorectal polyps.
  • [MeSH-major] Adenoma, Villous / metabolism. Hedgehog Proteins / metabolism. Intestinal Polyps / metabolism. Microtubule-Associated Proteins / metabolism. Neoplasm Proteins / metabolism
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / metabolism. Carrier Proteins / metabolism. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Nuclear Proteins / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17391730.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BIRC5 protein, human; 0 / Carrier Proteins; 0 / Hedgehog Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / MLH1 protein, human; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53
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34. Koh DC, Luchtefeld MA, Kim DG, Attal H, Monroe T, Ingersoll K: Microsatellite instability and MLH1 hypermethylation - incidence and significance in colorectal polyps in young patients. Colorectal Dis; 2007 Jul;9(6):521-6
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  • The original Bethesda criteria recommends MSI testing in patients <or=40 years diagnosed with adenomas.
  • About 53% of the polyps were tubulo-adenomas and 27% tubulovillous adenomas.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / genetics. Adolescent. Adult. Colonic Neoplasms / genetics. DNA Methylation. Female. Humans. Immunohistochemistry. Male. Nuclear Proteins

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  • (PMID = 17573746.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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35. de Jong AE, Morreau H, Nagengast FM, Mathus-Vliegen EM, Kleibeuker JH, Griffioen G, Cats A, Vasen HF: Prevalence of adenomas among young individuals at average risk for colorectal cancer. Am J Gastroenterol; 2005 Jan;100(1):139-43
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  • [Title] Prevalence of adenomas among young individuals at average risk for colorectal cancer.
  • OBJECTIVES: We evaluated the prevalence and characteristics of adenomas in a young population not genetically predisposed for the development of colorectal cancer (CRC).
  • RESULTS: At first colonoscopy (n = 342; 50% males, mean age 37 yr) a total of 19 adenomas (10 males, mean age 50 yr, range 24-91 yr) and two CRCs (2 males, age 49 and 72 yr) were identified, and at first sigmoidoscopy (n = 102; 53% males, mean age 29 yr) three adenomas (2 males, age 8, 40, and 41 yr) were found.
  • A second colonoscopy was performed in 14 patients with, and in 162 patients without an adenoma.
  • Three of 14 patients (21%) developed a new adenoma (all >50 yr) and 8 of 162 (5%) patients developed their first adenoma during follow-up.
  • In the colonoscopy group, the cumulative proportion of patients free of adenomas at age 50 yr was 86%.
  • Of all adenomas diagnosed during colonoscopy (n = 49), 65% were located distal from the flexura lienalis.
  • Of the adenomas detected during all endoscopies (n = 53), 9.8% were > or =7 mm, 7.5% showed high-grade dysplasia, and 7.5% showed tubulovillous features.
  • CONCLUSIONS: On the basis of our findings during colonoscopy we conclude that the risk of developing adenomas/CRC in young individuals without genetic risk factors is low.
  • Adenoma surveillance programs should focus on young individuals with a positive family (or personal) history for adenomas/CRC, or on individuals >50 yr.
  • [MeSH-major] Adenoma / epidemiology. Colorectal Neoplasms / epidemiology

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  • (PMID = 15654793.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Lee JK, Ghosh P, McWhorter V, Payne M, Olson R, Krinsky ML, Ramamoorthy S, Carethers JM: Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma. World J Gastroenterol; 2008 Jul 21;14(27):4389-94
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  • [Title] Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma.
  • Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia.
  • The surgically-excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adenocarcinoma.
  • To the best of our knowledge, this is the first report of co-existence of sarcomatoid carcinoma and invasive adenocarcinoma with tubulovillous adenoma; all stages represented within the same tumor.
  • This observation supports the "monoclonal theory" of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Colorectal Neoplasms / pathology. Sarcoma / pathology

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  • (PMID = 18666331.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T32 DK007202
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2731194
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37. Savas B, Ensari A, Percinel S, Kuzu I, Kuzu MA, Bektas M, Cetinkaya H, Kursun N: The significance of beta-catenin, E-cadherin, and P-cadherin expressions in neoplastic progression of colorectal mucosa: an immunohistochemical study. Acta Gastroenterol Belg; 2007 Oct-Dec;70(4):339-44
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  • PATIENTS AND METHODS: Core tissue biopsies were taken from paraffin-embedded tissue blocks of 167 cases including 26 normal mucosae (NM), 99 colorectal polyps (10 hyperplastic polyps (HP), 8 traditional serrated (TSA), 17 tubular (TA), 37 tubulovillous (TVA), and 27 villous adenomas (VA)), 14 adenomas with intramucosal carcinoma (ACA), and 28 colorectal cancers (CCA).
  • E-cadherin and P-cadherin expressions in adenomas suggest that these molecules might have role in adenoma formation though not necessarily be involved in neoplastic progression.
  • [MeSH-minor] Adenoma / pathology. Adenoma, Villous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma / pathology. Carcinoma in Situ / pathology. Cell Membrane / ultrastructure. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Disease Progression. Female. Humans. Hyperplasia. Immunohistochemistry. Intestinal Polyps / pathology. Male. Middle Aged. Tissue Array Analysis


38. Tzouvala M, Lazaris AC, Papatheodoridis GV, Kouvidou C, Papathomas TG, Kavantzas N, Elemenoglou I, Karamanolis DG, Agapitos E: Potential role of apoptosis and apoptotic regulatory proteins in colorectal neoplasia: correlations with clinico-pathological parameters and survival. Dig Dis Sci; 2008 Feb;53(2):451-60
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  • Biopsies from 46 colorectal cancers, 121 adenomas, and 25 controls were studied using monoclonal antibodies against p53, bcl-2, mdm2 and the terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL) method for apoptosis.
  • P53 and bcl2 protein expression was higher in adenomas >or=1 cm (P < 0.03) and tubulovillous-villous adenomas (P < 0.03), and correlated with dysplasia (P < 0.03).
  • In conclusion, both bcl-2 and p53 immunohistochemical profiles may be useful adjuncts in detecting adenomas with a malignant potential, whereas bcl-2 could be used in combination with Dukes' stage as a predictor of prognosis in colorectal cancer.
  • [MeSH-major] Adenoma / metabolism. Apoptosis / physiology. Colorectal Neoplasms / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17562177.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 2.3.2.27 / MDM2 protein, human; EC 2.3.2.27 / Proto-Oncogene Proteins c-mdm2
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39. Nosho K, Yamamoto H, Takamaru H, Hamamoto Y, Goto A, Yoshida Y, Arimura Y, Endo T, Hirata K, Imai K: A case of colorectal carcinoma in adenoma analyzed by a cDNA array. Int J Colorectal Dis; 2005 May;20(3):287-91
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  • [Title] A case of colorectal carcinoma in adenoma analyzed by a cDNA array.
  • Microscopically, the large tumor consisted of a well-differentiated adenocarcinoma with a tubulovillous adenoma (TVA) component (carcinoma in adenoma).
  • K-ras mutation was detected in both CA and TVA lesions of the carcinoma in adenoma.
  • To clarify relevant alterations of gene expression associated with adenoma-carcinoma progression, the gene expression profiles of these tumor tissues were analyzed by a cDNA array.
  • The results were further substantiated by comparison of the gene expression profiles of CA and TVA lesions of the carcinoma in adenoma.
  • CONCLUSION: The results suggest that overexpression of IGF-II played an important role in the progression of adenoma to carcinoma in this patient.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma, Villous / genetics. Colorectal Neoplasms / genetics. DNA, Complementary / analysis. Neoplasms, Multiple Primary

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  • (PMID = 15490195.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Hamatani S, Wada R, Morita A, Hasegawa C, Mitsuda A, Hatori T, Nonaka H, Takahashi K, Gomi S, Shibuya K: Cellular kinetics and K-ras codon 12 mutations according to histomorphometric type of colorectal polyps with epithelial serrated proliferation. Oncol Rep; 2005 Jul;14(1):121-7
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  • Recent studies have examined cellular kinetics and genetic abnormalities in colorectal polyps with epithelial serrated proliferation (CP-ESP), including hyperplastic polyps, serrated adenomas, and tubulovillous adenomas.
  • CP-ESP and CP-ESP adjacent to carcinoma were morphologically classified as being positive or negative for maturation gradient and inferior and lateral glandular branching.

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  • (PMID = 15944778.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Codon; 0 / Ki-67 Antigen
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41. Rennert G, Almog R, Tomsho LP, Low M, Pinchev M, Chaiter Y, Bonner JD, Rennert HS, Greenson JK, Gruber SB: Colorectal polyps in carriers of the APC I1307K polymorphism. Dis Colon Rectum; 2005 Dec;48(12):2317-21
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  • The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared.
  • Adenomas with a tubular component (either tubular adenomas or tubulovillous adenomas), but not villous adenomas, were significantly more frequent among carriers (37.2 percent vs. 23.6 percent, P = 0.005).
  • CONCLUSION: Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
  • [MeSH-major] Adenoma / genetics. Colonic Polyps / genetics. Colorectal Neoplasms / genetics. Genes, APC. Polymorphism, Genetic

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  • (PMID = 16228836.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Apel D, Jakobs R, Spiethoff A, Riemann JF: Follow-up after endoscopic snare resection of duodenal adenomas. Endoscopy; 2005 May;37(5):444-8
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  • [Title] Follow-up after endoscopic snare resection of duodenal adenomas.
  • The aim of this study was to determine the long-term outcome after endoscopic resection of duodenal adenomas.
  • PATIENTS AND METHODS: Between January 1990 and April 2003 we retrospectively evaluated a group of patients who presented with nonampullary duodenal villous tumors but who did not have a polyposis syndrome.
  • Of these, 18 patients (6 men, 12 women; median age 67, range 50 - 81), with a total of 20 duodenal adenomas, were enrolled into the study.
  • Of these 20 tumors, 18 adenomas were tubulovillous, one was tubulous and one was villous.
  • Nineteen polyps were treated by snare excision and one adenoma was treated with argon plasma coagulation alone.
  • The success rate for endoscopic adenoma removal after a 3-month interval was 55 %.
  • CONCLUSIONS: Endoscopic snare excision of duodenal adenomas is an effective mode of treatment but an endoscopic surveillance program is mandatory in order to detect and treat recurrence.
  • [MeSH-major] Adenoma / surgery. Duodenal Neoplasms / surgery. Duodenoscopy. Neoplasm Recurrence, Local / surgery

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  • (PMID = 15844023.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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43. Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland CR: Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps. Cancer Epidemiol Biomarkers Prev; 2005 Sep;14(9):2253-6
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  • [Title] Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps.
  • BACKGROUND: Serrated adenomas are characterized by serrated crypts with dysplasia, and are distinguished from other polyps by their histology, but the genetic basis of serrated adenomas is unknown.
  • We investigated genetic alterations in colorectal polyps to determine if a specific pattern were associated with serrated adenomas.
  • METHODS: Sixty-six small (<10 mm) colorectal polyps were studied, including 11 hyperplastic polyps, 27 serrated adenomas, 9 tubular adenomas, 6 tubulovillous adenomas, and 3 villous adenomas.
  • Allelic imbalance of 18q was significantly more common (P < 0.05), whereas allelic imbalance of 5q and K-ras mutations were significantly less common (P < 0.05) in serrated adenomas compared with other polyps.
  • CONCLUSIONS: Serrated adenomas are significantly more likely to have allelic imbalance at 18q than other types of adenomas, and significantly less likely to have allelic imbalance at 5q or K-ras mutations.
  • Serrated adenomas seem to evolve through a different genetic pathway than other types of polyps in the colon.

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  • (PMID = 16172239.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA090231-05; United States / NCI NIH HHS / CA / R01 CA090231; United States / NCI NIH HHS / CA / R-01 CA72851; United States / NCI NIH HHS / CA / R01 CA090231-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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44. Gentner B, Kraus C, Schwab D, Benninger J, Wein A, Hahn EG, Brueckl WM: [A case of attenuated familial adenomatous polyposis coli (AFAP)]. Z Gastroenterol; 2005 Jun;43(6):591-5
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  • We describe an asymptomatic female patient who was diagnosed with multiple tubular and tubulovillous adenomas in the right-sided colon on routine colonoscopy at the age of 59 years.


45. Rubio CA, Nesi G, Messerini L, Zampi GC, Mandai K, Itabashi M, Takubo K: The Vienna classification applied to colorectal adenomas. J Gastroenterol Hepatol; 2006 Nov;21(11):1697-703
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  • [Title] The Vienna classification applied to colorectal adenomas.
  • In this study, that classification is applied to colorectal adenomas.
  • METHODS: Colorectal adenomas from 1552 patients were histologically classified according to the categories listed in Vienna: category 3, low-grade dysplasia; 4.1, high-grade dysplasia; 4.2, carcinoma in situ; 4.3, suspicious of intramucosal carcinoma; 5.1, intramucosal carcinoma; and 5.2, submucosal carcinoma.
  • Adenomas with dysplasia (categories 3 and 4.1) or with carcinoma (categories 4.2, 4.3, 5.1 and 5.2) were analyzed separately.
  • On basis of their configuration, adenomas were classified into tubular, tubulovillous, villous, serrated, microtubular and combined phenotypes (i.e. other than tubulovillous).
  • RESULTS: The highest percentage of adenomas with carcinoma was found amongst villous adenomas (29.6%), followed by combined adenomas (27.8%).
  • Villous adenoma with carcinoma was the most frequent neoplasia at all ages; combined adenomas with carcinoma were more frequent among younger patients.
  • In elderly patients (> or = 60 years of age) the highest percentage of adenomas with carcinoma was recorded in villous adenomas (28.1%), followed by serrated adenomas (19.2%).
  • Villous adenomas and combined adenomas with carcinoma were more frequent in males.
  • CONCLUSION: The Vienna classification of colorectal adenomas seems to be influenced by parameters inherent to the patient such as age and sex and by the histological phenotype of the adenoma.
  • [MeSH-major] Adenoma / classification. Colorectal Neoplasms / classification

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  • (PMID = 16984592.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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46. Pokala N, Delaney CP, Kiran RP, Brady K, Senagore AJ: Outcome of laparoscopic colectomy for polyps not suitable for endoscopic resection. Surg Endosc; 2007 Mar;21(3):400-3
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  • Mean polyp size was 3.1 cm, and pathology revealed tubular (n = 14), tubulovillous (n = 33) and villous adenoma (n = 2), pseudopolyp (n = 1), and prolapse of the appendix into the cecum mimicking an adenoma (n = 1).
  • High-grade dysplasia was seen in four tubular (33%) and five tubulovillous adenomas (15.5%).
  • Adenocarcinoma not identified at colonoscopy was found in 11 polyps (20%), 9 tubulovillous (27.8%) and both villous adenomas (100%).

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  • (PMID = 17180271.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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47. Park DI, Kim YH, Kim HS, Kim WH, Kim TI, Kim HJ, Yang SK, Byeon JS, Lee MS, Jung IK, Chung MK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS, Song JS: Diagnostic yield of advanced colorectal neoplasia at colonoscopy, according to indications: an investigation from the Korean Association for the Study of Intestinal Diseases (KASID). Endoscopy; 2006 May;38(5):449-55
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  • BACKGROUND AND STUDY AIMS: The factors that more accurately predict the detection of colorectal cancers and adenomas at colonoscopy are different.
  • The term "advanced adenoma" refers here to tubular adenomas of diameter of 11 mm or more, or to tubulovillous, villous, or severely dysplastic adenomas, irrespective of their size.
  • Advanced CRN was defined as advanced adenoma or invasive cancer.
  • RESULTS: Advanced CRN was found in 1227/17 307 patients (1176 advanced adenomas plus 51 carcinomas, 7.1 %).
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy / methods. Colorectal Neoplasms / diagnosis

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  • [ErratumIn] Endoscopy. 2006 Aug;38(8):852
  • (PMID = 16767578.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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48. Kwon HJ, Kim JH, Bae JM, Cho NY, Kim TY, Kang GH: DNA methylation changes in ex-adenoma carcinoma of the large intestine. Virchows Arch; 2010 Oct;457(4):433-41
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  • [Title] DNA methylation changes in ex-adenoma carcinoma of the large intestine.
  • Ex-adenoma carcinoma (EAC) is a carcinoma with contiguous adenoma element in its vicinity which provides a morphological evidence for adenoma-carcinoma sequence.
  • Twenty-two cases of cancers had contiguous tubulovillous adenomas and 17 cases had contiguous tubular adenomas.
  • Regardless of CIMP markers or nonrelated markers, a significant increase in the number of methylated genes was found from normal mucosa to adenoma, whereas no increase was found from adenoma to carcinoma.
  • Both ALU and LINE-1 showed a significant decrease of methylation levels from normal mucosa to adenoma (p < 0.05), but there is no difference between adenoma and cancer.
  • However, SAT2 methylation level exhibited a stepwise decrease from normal mucosa to adenoma to cancer.
  • Our findings suggest that morphological progression from traditional adenoma to carcinoma does not appear to be accompanied by increases in promoter CpG island hypermethylation or repetitive DNA hypomethylation, except for SAT2 hypomethylation which showed continuous progression during multistep carcinogenesis.
  • [MeSH-major] Adenoma / genetics. Carcinoma / genetics. Colorectal Neoplasms / genetics. CpG Islands. DNA Methylation

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  • (PMID = 20711609.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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49. Rubio CA, Stemme S, Jaramillo E, Lindblom A: Hyperplastic polyposis coli syndrome and colorectal carcinoma. Endoscopy; 2006 Mar;38(3):266-70
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  • Other colorectal lesions were found as follows: two patients each had one mixed polyp; there were 15 serrated adenomas in eight patients; and there were 30 tubular, tubulovillous, or villous adenomas in eight patients.
  • Of the four villous adenomas, three were associated with a CRC, but only one of the 15 serrated adenomas was associated with a CRC.
  • [MeSH-minor] Adenoma / pathology. Aged. Colonic Neoplasms / pathology. Female. Humans. Hyperplasia. Male. Middle Aged

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  • (PMID = 16528654.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 35
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50. Ricchetti T, Paci M, Cavazza A, Ferrari G, Annessi V, De Franco S, Sgarbi G: A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma. Tumori; 2005 Mar-Apr;91(2):210-2
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  • [Title] A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma.
  • We report a case of epithelioid angiosarcoma with multiple bilateral lung infiltration, bone metastasis, and metastasis of the lamina propria of a tubulovillous adenoma of the colon.
  • [MeSH-major] Adenoma / pathology. Basement Membrane / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secretion. Sigmoid Neoplasms / pathology

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  • (PMID = 15948556.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Endothelial Cell Adhesion Molecule-1
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51. Singhal M, Kang M, Narayanan S, Gupta R, Wig JD, Bal A: Duodenoduodenal intussusception. J Gastrointest Surg; 2009 Feb;13(2):386-8
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  • We present a case of duodenoduodenal intussusception secondary to a large tubulovillous adenoma causing gastric outlet and biliary obstruction in a 50-year-old female.
  • [MeSH-major] Adenoma, Villous / pathology. Duodenal Neoplasms / pathology. Intussusception / diagnosis. Intussusception / etiology

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52. Moseley B, Mwirigi NW, Bowen J: Clostridium septicum Aortitis and Cecal Adenocarcinoma. Case Rep Med; 2010;2010:121728
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  • We present a case of an 82-year-old male diagnosed with both C. septicum aortitis and a high-grade cecal tubulovillous adenoma.

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53. Cole BF, Logan RF, Halabi S, Benamouzig R, Sandler RS, Grainge MJ, Chaussade S, Baron JA: Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. J Natl Cancer Inst; 2009 Feb 18;101(4):256-66
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  • [Title] Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.
  • Randomized clinical trials have been conducted to evaluate the effectiveness of aspirin for reducing the risk of colorectal adenomas.
  • METHODS: We combined data from all randomized double-blind placebo-controlled trials that evaluated aspirin for the prevention of colorectal adenomas.
  • We used random-effects meta-analysis to estimate risk ratios and 95% confidence intervals (CIs) for the effect of aspirin on the occurrence of adenomas and of advanced lesions (ie, tubulovillous adenomas, villous adenomas, adenomas >or=1 cm in diameter, adenomas with high-grade dysplasia, or invasive cancer).
  • Each trial evaluated aspirin for the secondary prevention of colorectal adenomas.
  • A total of 2698 participants underwent colonoscopic follow-up and were included in the analysis of adenoma occurrence and advanced-lesion occurrence after randomization.
  • Among these participants, adenomas were found in 424 (37%) of the 1156 participants allocated to placebo and in 507 (33%) of the 1542 participants allocated to any dose of aspirin.
  • The pooled risk ratio of any adenoma for any dose of aspirin vs placebo was 0.83 (95% CI = 0.72 to 0.96).
  • CONCLUSION: Aspirin is effective for the prevention of colorectal adenomas in individuals with a history of these lesions.
  • [MeSH-major] Adenoma / prevention & control. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Anticarcinogenic Agents / administration & dosage. Aspirin / administration & dosage. Colorectal Neoplasms / prevention & control. Neoplasm Recurrence, Local / prevention & control


54. Dobrow MJ, Cooper MA, Gayman K, Pennington J, Matthews J, Rabeneck L: Referring patients to nurses: outcomes and evaluation of a nurse flexible sigmoidoscopy training program for colorectal cancer screening. Can J Gastroenterol; 2007 May;21(5):301-8
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  • Classifying the six patients according to the most advanced polyp histology, one patient had a negative colonoscopy (no polyps found), one patient's polyps were hyperplastic, one had a tubular adenoma, two had advanced neoplasia (tubulovillous adenomas) and one had adenocarcinoma.

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  • (PMID = 17505566.001).
  • [ISSN] 0835-7900
  • [Journal-full-title] Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • [ISO-abbreviation] Can. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 42
  • [Other-IDs] NLM/ PMC2657712
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55. Greenley CT, Ahmed B, Friedman L, Deitte L, Awad ZT: Laparoscopic management of sigmoidorectal intussusception. JSLS; 2010 Jan-Mar;14(1):137-9
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  • We report a case of sigmoidorectal intussusception caused by a large tubulovillous adenoma.

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  • (PMID = 20529540.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3021307
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56. Kim DH, Kim JW, Cho JH, Baek SH, Kakar S, Kim GE, Sleisenger MH, Kim YS: Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum. Int J Oncol; 2005 Oct;27(4):957-64
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  • An immunohistochemical study was performed in 10 normal rectal mucosa samples (NM) 21 hyperplastic polyps (HP), 20 serrated adenomas (SA), 25 tubular adenomas (TA), 13 tubulovillous adenomas (TVA), 7 villous adenomas (VA), 42 non-mucinous colorectal cancers (NMC), and 19 mucinous colorectal cancers (MC).
  • [MeSH-minor] Adenoma / metabolism. Cell Differentiation. Cell Line, Tumor. Cell Lineage. Cell Nucleus / metabolism. Cytoplasm / metabolism. Humans. Immunohistochemistry. Mucin 5AC. Mucin-2

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  • (PMID = 16142311.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins; 0 / Peptides; 0 / TFF1 protein, human; 0 / TFF3 protein, human; 0 / Tumor Suppressor Proteins; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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57. Burkart AL, Sheridan T, Lewin M, Fenton H, Ali NJ, Montgomery E: Do sporadic Peutz-Jeghers polyps exist? Experience of a large teaching hospital. Am J Surg Pathol; 2007 Aug;31(8):1209-14
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  • One patient had a history of high-grade dysplasia in a tubulovillous adenoma in the colon at 53 years, but no family cancer history.
  • Another had a history of pituitary adenoma at age 39, and the last had ductal breast carcinoma diagnosed 4 years before the discovery of the polyp.

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  • (PMID = 17667545.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Anand BS, Verstovsek G, Cole G: Tubulovillous adenoma of anal canal: a case report. World J Gastroenterol; 2006 Mar 21;12(11):1780-1
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  • [Title] Tubulovillous adenoma of anal canal: a case report.
  • We present a case of benign anal adenomas arising from the anus, an extremely rare diagnosis.
  • Microscopic examination revealed a tubulovillus adenoma with no areas of high grade dysplasia or malignant transformation.
  • We believe the tubulovillus adenoma arose from either an anal gland or its duct that opens into the anus.
  • [MeSH-major] Adenoma, Villous / diagnosis. Anus Neoplasms / diagnosis

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  • (PMID = 16586552.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4124358
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59. Ispas C, Yu J, Tarantino DR, Lara JF: Pathologic quiz case: a 44-year-old woman with a tubulovillous adenoma of the colon and liver and bone lesions. Small cell (neuroendocrine) carcinoma of the colon with metastasis and an associated, overlying villous adenoma. Arch Pathol Lab Med; 2005 Mar;129(3):412-4
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  • [Title] Pathologic quiz case: a 44-year-old woman with a tubulovillous adenoma of the colon and liver and bone lesions. Small cell (neuroendocrine) carcinoma of the colon with metastasis and an associated, overlying villous adenoma.
  • [MeSH-major] Adenoma, Villous / diagnosis. Bone Neoplasms / secondary. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / secondary. Colonic Neoplasms / diagnosis. Liver Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis

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  • (PMID = 15737043.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. V Schönfeld J, Hinzmann S: Missed colonic adenomas in routine primary care endoscopy: a prospective tandem colonoscopy study. Z Gastroenterol; 2010 Oct;48(10):1207-10
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  • [Title] Missed colonic adenomas in routine primary care endoscopy: a prospective tandem colonoscopy study.
  • Several lines of independent evidence, however, suggest that a significant number of small adenomas and also some advanced lesions are missed even by experienced endoscopists.
  • A total of 98 neoplastic lesions were identified in 34 patients at the index colonoscopy, an additional 53 adenomas were removed at the second colonoscopy, 33 of them smaller than 5 mm.
  • 25 out of 53 missed adenomas were identified between the coecum and the right colonic flexure.
  • 12 of the additional lesions were considered significant lesions (larger than 10 mm or tubulovillous adenoma), nine of these were located between the coecum and the right colonic flexure.
  • In 24 patients repeat colonoscopy detected adenomas not described in the original report.
  • About one-third of adenomas were missed in 40 routine colonoscopies, most of them only small and therefore probably of little clinical significance.
  • Adenomas in the right colon seem to be a particular problem.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Colonoscopy / statistics & numerical data. Medical Errors / prevention & control

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 20886425.001).
  • [ISSN] 1439-7803
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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61. Ono S, Fujishiro M, Goto O, Kodashima S, Omata M: Submerging endoscopic submucosal dissection leads to successful en bloc resection of colonic laterally spreading tumor with submucosal fat. Gut Liver; 2008 Dec;2(3):209-12
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  • The pathological examination indicated the curative resection of a tubulovillous adenoma.

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  • (PMID = 20485649.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2871645
  • [Keywords] NOTNLM ; Adipose tissue / Colonic neoplasms / Colonoscopy / Resection / Submucosa
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62. Lai HC, Chan CY, Peng CY, Chen CB, Huang WH: Pyogenic liver abscess associated with large colonic tubulovillous adenoma. World J Gastroenterol; 2006 Feb 14;12(6):990-2
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  • [Title] Pyogenic liver abscess associated with large colonic tubulovillous adenoma.
  • Rarely, liver abscess has been reported as the presenting manifestation of colonic tubulovillous adenoma.
  • Colonoscopy revealed large polypoid tumors with pathological findings of tubulovillous adenoma in both cases.
  • [MeSH-major] Adenoma / pathology. Adenoma / radiography. Colonic Neoplasms / pathology. Colonic Neoplasms / radiography. Liver Abscess, Pyogenic / pathology. Liver Abscess, Pyogenic / radiography

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  • (PMID = 16521236.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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63. Kung JW, Levine MS, Glick SN, Lakhani P, Rubesin SE, Laufer I: Colorectal cancer: screening double-contrast barium enema examination in average-risk adults older than 50 years. Radiology; 2006 Sep;240(3):725-35
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  • The remaining 14 patients had a total of 21 neoplastic lesions 1 cm or larger, including 11 tubular adenomas, seven tubulovillous adenomas, one villous adenoma with marked dysplasia, and two cancers.

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  • [Copyright] (c) RSNA, 2006.
  • (PMID = 16837671.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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64. Barry EL, Baron JA, Grau MV, Wallace K, Haile RW: K-ras mutations in incident sporadic colorectal adenomas. Cancer; 2006 Mar 1;106(5):1036-40
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  • [Title] K-ras mutations in incident sporadic colorectal adenomas.
  • In the current study, the authors investigated associations with K-ras mutation in incident sporadic colorectal adenomas that occurred during a chemoprevention trial of calcium supplementation.
  • METHODS: K-ras genotyping was performed on 303 colorectal adenomas that were removed from 207 participants during the follow-up phase of the Calcium Polyp Prevention Study.
  • RESULTS: The adenomas analyzed had a mean estimated size of 0.5 cm, and 3.0% were identified with mutations (95% confidence interval [95% CI], 1.3-4.4%).
  • These mutations were more common in larger adenomas (risk ratio [RR], 12.7 for tumors that measured > 0.5 cm vs. < or = 0.5 cm; 95% CI, 2.7-59.7), in adenomas with more advanced histology (RR, 20.6 for tubulovillous/villous vs. tubular; 95% CI, 4.4-96.0), and in adenomas that were located in the rectum compared with the colon (RR, 8.4; 95% CI, 2.3-30.5).
  • CONCLUSIONS: Compared with previous studies, the current analysis was novel, because it focused on incident adenomas that were diagnosed within a few years of a previous "clean" colonoscopy.
  • The results provided evidence for a very low rate of K-ras mutation among these small, early adenomas and strong support for a role of K-ras mutations in adenoma progression.

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  • (PMID = 16456810.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA046927; United States / NCI NIH HHS / CA / CA-046927
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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65. Selcuk H, Korkmaz M, Kanbay M, Tore E, Sumer H, Unal H, Yeloglu O, Gur G, Bilezikci B, Demirhan B, Yilmaz U, Boyacioglu S: Total colonic polyp diameter: a marker for the risk of malignancy? Hepatogastroenterology; 2008 May-Jun;55(84):936-9
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  • The polyps were further categorized by histopathologic component as "unfavorable" or "favorable" and were divided into 2 groups: group 1 (those identified as carci noma, carcinoma in situ, villous adenoma, and tubulovillous adenoma with a villous component of more than 25%) and group 2 (mixed adenomatous polyps with various degrees of hyperplastic or inflammatory components and adenomas with a tubular component of more than 75%).
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Adenomatous Polyps / pathology. Adult. Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Colonoscopy. Female. Humans. Male. Middle Aged. Prognosis. Risk Factors

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  • (PMID = 18705301.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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66. Yoon WJ, Lee DH, Jung YJ, Jeong JB, Kim JW, Kim BG, Lee KL, Lee KH, Park YS, Hwang JH, Kim JW, Kim N, Lee JK, Jung HC, Yoon YB, Song IS: Histologic characteristics of gastric polyps in Korea: emphasis on discrepancy between endoscopic forceps biopsy and endoscopic mucosal resection specimen. World J Gastroenterol; 2006 Jul 7;12(25):4029-32
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  • Pathological results on resected specimens were as follows: tubular adenoma 45.9%, hyperplastic polyp 31.8%, inflammatory polyp 9.4%, hamartoma 3.5%, fundic gland polyp 2.4%, tubulovillous adenoma 2.4%, adenocarcinoma 2.4%, dysplasia 1.1%, and mucosal pseudolipomatosis 1.1%.
  • Approaches to review of the histology of an entire polyp should be performed, especially when an adenoma is suspected.

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  • (PMID = 16810753.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4087715
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67. Kadiyska TK, Kaneva RP, Nedin DG, Alexandrova AB, Gegova AT, Lalchev SG, Christova T, Mitev VI, Horst J, Bogdanova N, Kremensky IM: Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family. World J Gastroenterol; 2006 Dec 28;12(48):7848-51
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  • The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining.

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  • (PMID = 17203532.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
  • [Other-IDs] NLM/ PMC4087554
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68. Ozsunar Y, Coskun G, Delibaş N, Uz B, Yükselen V: Diagnostic accuracy and tolerability of contrast enhanced CT colonoscopy in symptomatic patients with increased risk for colorectal cancer. Eur J Radiol; 2009 Sep;71(3):513-8
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  • Two masses and eight polyps, consisted of 1 tubulovillous, 1 tubular, 2 villous adenoma, 4 adenomatous polyp, 4 adenocarcinoma, were identified.

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  • (PMID = 18597964.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media
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69. Rao VS, Al-Mukhtar A, Rayan F, Stojkovic S, Moore PJ, Ahmad SM: Endoscopic laser ablation of advanced rectal carcinoma--a DGH experience. Colorectal Dis; 2005 Jan;7(1):58-60
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  • RESULTS: Eleven patients (7 males, 4 females; mean age 83.6 years, range 77-90 years) underwent endoscopic laser ablation in a District General Hospital --8 for rectal carcinoma, 2 for rectosigmoid tumour and 1 for recurrent tubulovillous adenoma.
  • [MeSH-major] Adenoma, Villous / surgery. Carcinoma / surgery. Laser Therapy. Rectal Neoplasms / surgery. Sigmoid Neoplasms / surgery. Sigmoidoscopy

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  • (PMID = 15606586.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Meniconi RL, Caronna R, Benedetti M, Fanello G, Ciardi A, Schiratti M, Papini F, Farelli F, Dinatale G, Chirletti P: Inflammatory myoglandular polyp of the cecum: case report and review of literature. BMC Gastroenterol; 2010;10:10
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  • There was also another little polyp next to the ileocecal valve, not revealed at the colonoscopy, 0.8 cm in diameter, diagnosed as tubulovillous adenoma with low grade dysplasia.

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  • (PMID = 20102635.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2828397
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71. Darwood RJ, Wheeler JM, Borley NR: Transanal endoscopic microsurgery is a safe and reliable technique even for complex rectal lesions. Br J Surg; 2008 Jul;95(7):915-8
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  • RESULTS: Seventy-one lesions (13 carcinomas and 58 tubulovillous adenomas) were identified.
  • [MeSH-major] Adenoma, Villous / surgery. Carcinoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • [Copyright] (c) 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 18496889.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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72. Spring KJ, Zhao ZZ, Karamatic R, Walsh MD, Whitehall VL, Pike T, Simms LA, Young J, James M, Montgomery GW, Appleyard M, Hewett D, Togashi K, Jass JR, Leggett BA: High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology; 2006 Nov;131(5):1400-7
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  • [Title] High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy.
  • This prospective study examined the prevalence of sessile serrated adenomas and determined the incidence of BRAF and K-ras mutations in different types of polyps.
  • Most (60%) were adenomas (tubular adenomas, tubulovillous adenomas), followed by hyperplastic polyps (29%), sessile serrated adenomas (SSAs; 9%), traditional serrated adenomas (0.7%), and mixed polyps (1.7%).
  • Adenomas were more prevalent in the proximal colon (73%), as were SSAs (75%), which tended to be large (64% >5 mm).
  • BRAF mutation was rare in adenomas (1/248 [0.4%]) but common in SSAs (78%), traditional serrated adenomas (66%), mixed polyps (57%), and microvesicular hyperplastic polyps (70%).
  • K-ras mutations were significantly associated with goblet cell hyperplastic polyps and tubulovillous adenomas (P < .001).
  • [MeSH-major] Adenoma / genetics. Colonic Neoplasms / genetics. Colonoscopy. Mutation. Proto-Oncogene Proteins B-raf / genetics

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  • [CommentIn] Gastroenterology. 2006 Nov;131(5):1631-4 [17067594.001]
  • (PMID = 17101316.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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73. Tamiolakis D, Venizelos I: Inverse correlation between HLA-DR antigen expression and CD4 positive lymphocytic populations in normal mucosa, tubulovillous adenoma, and invasive carcinoma of the colon. Cesk Patol; 2006 Apr;42(2):52-8
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  • [Title] Inverse correlation between HLA-DR antigen expression and CD4 positive lymphocytic populations in normal mucosa, tubulovillous adenoma, and invasive carcinoma of the colon.
  • In this study we used immunohistochemistry to analyse the expression of HLA-DR on epithelial cells of normal colonic mucosa, tubulovillous adenoma, and invasive carcinoma, as well as the magnitude of the stromal T lymphocytes at the relevant sites.
  • Yet, we investigated the association of HLA-DR plus DQ genes and adenoma or carcinoma by PCR.
  • MATERIALS AND METHODS: 31 cases of normal colonic mucosa, 12 cases of tubulovillous adenoma, and 39 cases of invasive carcinoma were surveyed for the detection of HLA-DR monoclonal antigen, and the T helper (TH) marker (CD4) in the stroma (lamina propria) of the relevant cases.
  • RESULTS: HLA-DR was expressed in 20 of 31 normal colonic mucosas (64.5%), 4 of 12 adenomas (33.3%), and in 10 of 39 invasive carcinomas (25.6%).
  • No significant correlation between HLA-DR plus DQ genes and adenoma or cancer of the colon was found.
  • CD4 positive cells were found in 9 of 31 normal colonic mucosas (29%), 5 of 12 adenomas (42%), and in 26 of 39 invasive carcinomas (67%).
  • HLA-DR and DQ genes do not contribute to a susceptibility to adenoma or carcinoma.
  • [MeSH-major] Adenoma, Villous / immunology. CD4-Positive T-Lymphocytes / pathology. Carcinoma / immunology. Colonic Neoplasms / immunology. HLA-DR Antigens / analysis. Intestinal Mucosa / immunology

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  • [CommentIn] Ann Saudi Med. 2009 Nov-Dec;29(6):489 [20232495.001]
  • (PMID = 16715627.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Duplicate Publication; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / HLA-DR Antigens
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74. Tamiolakis D, Nicolaidou S, Bolioti S, Tzilivaki A: Prognostic significance of major histocompatibility complex class II antigens (HLA-DR) in normal colonic mucosa, tubulovillous adenoma, and invasive colonic carcinoma. Ann Saudi Med; 2006 Mar-Apr;26(2):133-7
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  • [Title] Prognostic significance of major histocompatibility complex class II antigens (HLA-DR) in normal colonic mucosa, tubulovillous adenoma, and invasive colonic carcinoma.
  • [MeSH-major] Adenoma, Villous / immunology. Carcinoma / immunology. Colonic Neoplasms / immunology. Intestinal Mucosa / immunology

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  • [CommentIn] Ann Saudi Med. 2009 Nov-Dec;29(6):489 [20232495.001]
  • (PMID = 16761451.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Duplicate Publication; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / HLA-DQ Antigens; 0 / HLA-DR Antigens
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75. Eriksen JR, Ibsen PH, Gyrtrup HJ: [Granular cell tumor of the colon--Abrikossoff's tumor]. Ugeskr Laeger; 2006 May 22;168(21):2080-1
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  • Histopathologic examination of the specimen showed a tubulovillous adenoma with moderate dysplasia and an adjacent 1 x 1 cm submucosal tumor classified as a benign GCT due to the appearance in the light microscope and immunohistochemical analysis.
  • To our knowledge, this is the first reported case of synchronic adenoma and GCT in the colon.
  • To date there is no evidence of any association or disposing factors between GCT in the colon and colonic adenomas or malignancy.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 16768929.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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76. Woodland JG: CDX-2 and MIB-1 expression in the colorectum: correlation with morphological features of adenomatous lesions. Br J Biomed Sci; 2006;63(2):68-73
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  • Transformation from normal to malignant mucosa is a multistep process involving specific gene mutations and is called the adenoma-carcinoma sequence.
  • Histologically, adenomas are of three types (tubular, tubulovillous and villous) and the extent of mucosal cellular abnormality of three grades (mild, moderate and severe).
  • This is a retrospective study of colorectal adenomas, and haematoxylin and eosin (H&E) and immunocytochemical staining for CDX-2 and MIB-1 (a cell proliferation marker) are performed on each case.
  • Comment is made on the morphological features (adenoma type and dysplasia severity) and the grade of CDX-2 and MIB-1 expression.
  • This study showed that dysplasia severity is linked to cellular proliferation (P=0.011) but adenoma type was not (P=0.54).
  • [MeSH-major] Adenoma / chemistry. Colorectal Neoplasms / chemistry. Homeodomain Proteins / analysis. Ki-67 Antigen / analysis. Neoplasm Proteins / analysis. Trans-Activators / analysis

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  • (PMID = 16871998.001).
  • [ISSN] 0967-4845
  • [Journal-full-title] British journal of biomedical science
  • [ISO-abbreviation] Br. J. Biomed. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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77. Tachezy R, Jirasek T, Salakova M, Ludvikova V, Kubecova M, Horak L, Mandys V, Hamsikova E: Human papillomavirus infection and tumours of the anal canal: correlation of histology, PCR detection in paraffin sections and serology. APMIS; 2007 Mar;115(3):195-203
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  • In our recent study the presence of HPV was detected by PCR in biopsy specimens of 42 different anal tumours, including SCCA and its histological variants (n=22), adenocarcinomas (n=5), tubulovillous adenomas (n=5) and anal condylomas (n=10).
  • Two adenomas showed presence of HPV16; one showed simultaneous positivity for HPV33.

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  • (PMID = 17367464.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9004-22-2 / Globins
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78. Doornebosch PG, Bronkhorst PJ, Hop WC, Bode WA, Sing AK, de Graaf EJ: The role of endorectal ultrasound in therapeutic decision-making for local vs. transabdominal resection of rectal tumors. Dis Colon Rectum; 2008 Jan;51(1):38-42
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  • However, feasibility of endorectal ultrasound and its role in therapeutic decision-making in presumed rectal adenomas is sparsely studied.
  • METHODS: Endorectal ultrasound was performed in 268 tumors referred for local excision because biopsies showed tubulovillous adenoma.
  • In diagnosing tubulovillous adenomas, sensitivity and specificity of endorectal ultrasound was 89 and 86 percent, respectively.
  • CONCLUSIONS: Endorectal ultrasound is technically feasible in almost all presumed rectal adenomas, referred for local excision.
  • Proper endorectal ultrasound interpretation is possible in 78 percent of all presumed rectal adenomas.
  • Endorectal ultrasound is very reliable in diagnosing tubulovillous adenomas, and therapeutic decision-making regarding local excision vs. radical surgery based on endorectal ultrasound is valid.

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  • (PMID = 18038181.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Nieuwenhuis DH, Draaisma WA, Verberne GH, van Overbeeke AJ, Consten EC: Transanal endoscopic operation for rectal lesions using two-dimensional visualization and standard endoscopic instruments: a prospective cohort study and comparison with the literature. Surg Endosc; 2009 Jan;23(1):80-6
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  • RESULTS: Between 2004 and 2006, 31 patients with a median age of 75 years (range, 33-87 years) underwent 31 TEOs for a total of 36 rectal lesions (29 tubulovillous adenomas and 7 adenocarcinomas).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Endoscopes. Endoscopy. Rectal Neoplasms / surgery. Surgery, Computer-Assisted / instrumentation

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  • (PMID = 18443874.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] Germany
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80. Winkler A, Hinterleitner TA, Högenauer C, Hauser H, Langner C: Juvenile polyposis of the stomach causing recurrent upper gastrointestinal bleeding. Eur J Gastroenterol Hepatol; 2007 Jan;19(1):87-90
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  • Colonoscopy including the terminal ileum revealed a single tubulovillous adenoma, but no hamartomatous polyps, rendering a final diagnosis of juvenile polyposis of the stomach.

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  • (PMID = 17206083.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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81. Pezzoli A, Matarese V, Rubini M, Simoni M, Caravelli GC, Stockbrugger R, Cifalà V, Boccia S, Feo C, Simone L, Trevisani L, Liboni A, Gullini S: Colorectal cancer screening: results of a 5-year program in asymptomatic subjects at increased risk. Dig Liver Dis; 2007 Jan;39(1):33-9
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  • Adenomas and cancers were found in 122 (21.7%) and 12 (2.1%) subjects, respectively.
  • Histological examination in 181 persons with lesions (32.8%) showed (most serious lesion quoted) 47 hyperplastic polyps (26% of all lesions), 2 serrated adenomas (1.1%), 68 tubular adenomas (48%), 24 tubulovillous adenomas (13.3%), 9 adenomas with high grade dysplasia (5%) and 12 adenocarcinomas (6.6%).
  • [MeSH-minor] Adenoma / diagnosis. Colonoscopy. Female. Humans. Male. Middle Aged. Pedigree. Predictive Value of Tests. Prevalence. Risk Factors

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  • (PMID = 17049323.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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82. O'Connor DJ, Feinberg E, Jang J, Vemulapalli P, Camacho D: Single-incision laparoscopic-assisted right colon resection for cancer. JSLS; 2010 Oct-Dec;14(4):558-60
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  • METHODS: A 77-year-old woman with a tubulovillous adenoma in her cecum underwent a laparoscopic right colectomy using a single port placed through the umbilicus.

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  • (PMID = 21605522.001).
  • [ISSN] 1086-8089
  • [Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons
  • [ISO-abbreviation] JSLS
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Kinney TP, Merel N, Hart J, Joseph L, Waxman I: Microsatellite analysis of sporadic flat and depressed lesions of the colon. Dig Dis Sci; 2005 Feb;50(2):327-30
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  • Of these specimens, eight were tubular adenomas, three were tubulovillous adenomas, and five were carcinomas in situ.
  • [MeSH-major] Adenoma, Villous / genetics. Colonic Neoplasms / genetics. Microsatellite Repeats

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  • (PMID = 15745095.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Shiba H, Misawa T, Wakiyama S, Iida T, Ishida Y, Yanaga K: Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case. J Gastrointest Cancer; 2010 Jun;41(2):138-40
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  • Upper gastrointestinal endoscopy revealed a pedunculated tumor in the ampulla of Vater with a diameter of 50 mm, which was biopsied and diagnosed as tubulovillous adenoma with moderate atypia.
  • Histological examination revealed well-differentiated tubular adenocarcinoma in tubular adenoma with severe atypia limited to the mucosa.

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  • (PMID = 20012229.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Yoo TW, Park DI, Kim YH, Kim HS, Kim WH, Kim TI, Kim HJ, Yang SK, Byeon JS, Lee MS, Jung IK, Chung MK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS, Song JS: Clinical significance of small colorectal adenoma less than 10 mm: the KASID study. Hepatogastroenterology; 2007 Mar;54(74):418-21
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  • [Title] Clinical significance of small colorectal adenoma less than 10 mm: the KASID study.
  • BACKGROUND/AIMS: Polypectomy is the current modality of choice to prevent benign colorectal adenoma from progressing to an invasive cancer.
  • However, in cases of small colorectal adenoma, it remains unclear as to whether polypectomy is actually an effective treatment modality.
  • We evaluated the clinical significance of polypectomy in cases of small colorectal adenomas, measuring less than 10 mm.
  • A total of 5996 colorectal adenomas were detected and divided into 5 groups according to their size (Group 1; 1-5 mm, Group 2; 6-7 mm, Group 3; 8-9 mm, Group 4; 10-19 mm, Group 5; more than 20 mm).
  • The term 'advanced adenoma' refers here to tubular adenomas with diameters of at least 10 mm, or to tubulovillous, villous, or high-grade dysplasia, irrespective of size.
  • RESULTS: As the sizes of the adenomas increased, the prevalence of advanced adenoma was also observed to increase.
  • In Groups 2 and 3, the prevalence of tubulovillous or villous adenoma were higher than was expected (5.2% and 6.6%, p < 0.001).
  • CONCLUSIONS: In cases of small colorectal adenomas, measuring between 6 and 9 mm, the prevalence of cancer was at least as high as that seen in the cases of colorectal adenomas measuring between 10 and 19 mm.
  • Therefore, small colorectal adenomas measuring between 6 and 9 mm should not be ignored, in order to decrease the prevalence of colorectal cancer.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / pathology. Adenoma, Villous / surgery. Adult. Aged. Cell Transformation, Neoplastic / pathology. Cohort Studies. Colonoscopy. Female. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Male. Middle Aged. Risk Factors

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  • (PMID = 17523287.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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86. Elwing JE, Gao F, Davidson NO, Early DS: Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women. Am J Gastroenterol; 2006 Aug;101(8):1866-71
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  • [Title] Type 2 diabetes mellitus: the impact on colorectal adenoma risk in women.
  • Despite several studies linking insulin resistance to increased CRC risk, there are limited data on colorectal adenoma risk in diabetic women.
  • We hypothesized that diabetic women would have increased rates of colorectal adenomas relative to a group of nondiabetic women.
  • METHODS: Colorectal adenoma rates were determined in 100 estrogen-negative women with type 2 diabetes mellitus and compared with 500 nondiabetic, estrogen-negative controls.
  • Adenomas were defined as any adenoma or advanced adenoma (villous or tubulovillous features, size >1 cm or high-grade dysplasia).
  • A multivariate model including age, race, diabetes, hypertension, hypercholesterolemia, body mass index, and nonsteroidal anti-inflammatory drug status was used to determine the independent effects of diabetes on colorectal adenoma incidence.
  • RESULTS: Diabetics as compared with nondiabetics had greater rates of any adenoma (37%vs 24%, p= 0.009) and advanced adenomas (14%vs 6%, p= 0.009).
  • Two hundred forty-five obese subjects compared with 355 nonobese subjects had a higher rate of any adenoma (32%vs 22%, p= 0.001).
  • Obese diabetics compared with nonobese, nondiabetics had greater rates of any adenoma (42%vs 23%, p< or = 0.001) and advanced adenomas (19%vs 7%, p< or = 0.001).
  • Multivariate analysis showed that adenomas and advanced adenomas were independently predicted by diabetes (p < 0.05) and adenomas by age.
  • DISCUSSION: Women with type 2 diabetes mellitus had higher rates of colorectal adenomas as compared with lean and nondiabetic women.
  • This finding adds to the evidence that type 2 diabetes is an important factor in the progression of the adenoma-carcinoma sequence.

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  • [CommentIn] Am J Gastroenterol. 2007 Feb;102(2):466-7 [17311671.001]
  • [CommentIn] Am J Gastroenterol. 2007 Mar;102(3):692 [17335459.001]
  • (PMID = 16790036.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK056341-05S2; United States / NIDDK NIH HHS / DK / P30 DK056341; United States / NHLBI NIH HHS / HL / HL38180; None / None / / P30 DK056341-06; United States / NIDDK NIH HHS / DK / P30 DK056341-06; United States / NIDDK NIH HHS / DK / DK52574; None / None / / P30 DK056341-05S2; United States / NIDDK NIH HHS / DK / DK56260
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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87. Song ZG, Liu AJ, Wang DJ, Chen W: [Tubulovillous adenoma of vagina: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2009 Mar;38(3):202
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  • [Title] [Tubulovillous adenoma of vagina: report of a case].
  • [MeSH-major] Adenoma, Villous / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 19575861.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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88. Mehrabi S, Akwe JA, Adams G Jr, Grizzle W, Yao X, Aikhionbare FO: Analysis of mtDNA sequence variants in colorectal adenomatous polyps. Diagn Pathol; 2010;5:66
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  • Adenomatous polyps have been classified into three histologic types; tubular, tubulovillous, and villous with increasing malignant potential.
  • A germline variant G9055A in the MT-ATP 6 gene had a frequency of 100% (17/17) in tubular and 57% (13/23) in villous adenomas; no corresponding variant was in tubulovillous adenomas.
  • Furthermore, A9006G variant at MT-ATP 6 gene was observed at frequency of 57% (13/23) in villous adenomas only.
  • Interestingly, variants A9006G and G9055A were absent in the villous tissue samples that were clinicopathological designated as "polyvillous adenomas".

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  • (PMID = 20929553.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM058268
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Other-IDs] NLM/ PMC2959018
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89. Huang WY, Chatterjee N, Chanock S, Dean M, Yeager M, Schoen RE, Hou LF, Berndt SI, Yadavalli S, Johnson CC, Hayes RB: Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev; 2005 Jan;14(1):152-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.
  • Cigarette smoking is a risk factor for colorectal adenoma, a precursor of colorectal cancer.
  • Among participants randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we evaluated risks for advanced adenoma in relation to cigarette use and these two EPHX1 variants.
  • We compared 772 cases with advanced adenoma (adenoma >/=1 cm or containing high-grade dysplasia or villous, including tubulovillous, elements) of the distal colon (left-sided, descending colon and sigmoid or rectum) to 777 gender- and age-matched controls who were screen-negative for left-sided adenoma.
  • Compared to those with homozygous genotypes predicting low EPHX1 activity, advanced adenoma risks tended to be elevated for carriers of (113)TyrTyr [odds ratios (OR), 1.5; 95% confidence intervals (CI), 1.0-2.2] and (139)ArgArg (OR, 1.4; 95% CI, 0.8-2.5) and for subjects who carried a greater number of the alleles ((113)Tyr or (139)Arg) associated with high predicted enzymatic activity (P(trend) = 0.03).
  • In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Epoxide Hydrolases / genetics. Polymorphism, Genetic. Smoking / adverse effects

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  • (PMID = 15668489.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.3.2.- / Epoxide Hydrolases
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90. Kaklamanis L, Trichas M, Amarantidis K, Spathari N, Micheli A, Karayiannakis A, Chatzaki E, Georgoulias V, Kakolyris S: VEGF expression in the colorectal adenoma-carcinoma sequence. Oncol Res; 2006;15(9):445-51
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  • [Title] VEGF expression in the colorectal adenoma-carcinoma sequence.
  • VEGF and p53 expression were evaluated in 16 hyperplastic polyps, 35 solitary tubular and tubulovillous adenomas, and 47 cases of sporadic colorectal carcinomas arising on the basis of preexisting adenomas, using immunohistochemistry.
  • Carcinomas arising from VEGF-positive adenomas were mostly VEGF positive (10/11, 91%), whereas in 28/36 (78%) carcinomas arising from VEGF-negative adenomas VEGF expression was not detected.
  • We conclude that VEGF associates with angiogenesis in colorectal cancer, and its pattern of expression in adenomas is maintained in the arising carcinomas.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Colorectal Neoplasms / metabolism. Gene Expression. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 16555551.001).
  • [ISSN] 0965-0407
  • [Journal-full-title] Oncology research
  • [ISO-abbreviation] Oncol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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91. Seike K, Koda K, Oda K, Kosugi C, Shimizu K, Nishimura M, Shioiri M, Takano S, Ishikura H, Miyazaki M: Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasms. Am J Gastroenterol; 2006 Jun;101(6):1362-9
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  • The correlation between ACF grading and the prevalence of colonic advanced neoplasm, any adenoma>or=1 cm in size and/or with villous or tubulovillous morphology, and/or with high-grade dysplasia or invasive cancer, was assessed.

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  • (PMID = 16771962.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; T42P99266K / Methylene Blue
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92. Neogi P, Misra A, Agrawal R: Duodenal adenoma presenting as duodenojejunal intussusception. Acta Biomed; 2008 Aug;79(2):137-9
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  • [Title] Duodenal adenoma presenting as duodenojejunal intussusception.
  • However during laparotomy, duodenojejunal intussusception was found along with an adenoma in the third part of the duodenum associated with a lax ligament of Treitz.
  • The intussusception was reduced and the parts of the duodenum containing the adenoma were resected, followed by an end-to-end duodenojejunal anastomosis.
  • To the best of our knowledge, this is the first reported case of tubulovillous adenoma in the third part of the duodenum presenting as intussusception in an adult.
  • [MeSH-major] Adenoma / pathology. Duodenal Diseases / diagnosis. Duodenal Neoplasms / pathology. Intussusception / diagnosis. Jejunal Diseases / diagnosis

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  • (PMID = 18788510.001).
  • [ISSN] 0392-4203
  • [Journal-full-title] Acta bio-medica : Atenei Parmensis
  • [ISO-abbreviation] Acta Biomed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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93. Kim DW, Jung SA, Park SA, Kim CG: Multifocal Colonic Lesions Detected by (18)F-FDG PET/CT: Correlation with Histopathology and Gross Specimen. Nucl Med Mol Imaging; 2010 Sep;44(3):226-7
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  • The histopathologic examination of the postoperative gross specimen revealed a tubular adenoma, a tubulovillous adenoma and an adenocarinoma.
  • The maximal standardized uptake value (SUVmax) of a tubulovillous adenoma was much higher than that of adenocarcinoma.
  • This patient could be considered as a representative case highlighting that SUVmax is not a reliable indicator for discriminating colon cancer from colonic adenomas.

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  • (PMID = 24899955.001).
  • [ISSN] 1869-3474
  • [Journal-full-title] Nuclear medicine and molecular imaging
  • [ISO-abbreviation] Nucl Med Mol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC4042939
  • [Keywords] NOTNLM ; 18F-FDG PET/CT / Colon cancer / Colonic adenoma
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94. Alexander S, Bourke MJ, Williams SJ, Bailey A, Co J: EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos). Gastrointest Endosc; 2009 Jan;69(1):66-73
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  • [Title] EMR of large, sessile, sporadic nonampullary duodenal adenomas: technical aspects and long-term outcome (with videos).
  • OBJECTIVE: Our purpose was to evaluate the efficacy and safety of EMR of large (>15 mm) duodenal adenomas.
  • PATIENTS: Patients with large (>15 mm) sporadic nonampullary duodenal adenomas managed by a standardized technique who were referred by other specialist endoscopists for endoscopic treatment.
  • METHODS: Five-year data from patients undergoing EMR for large duodenal adenomas were reviewed retrospectively.
  • Post-EMR histologic examination revealed mucosal adenocarcinoma in 1, low-grade tubulovillous adenoma (TVA) in 16, high- or focal high-grade TVA in 3 patients, and 1 with both high-grade TVA and carcinoid.
  • During follow-up, 5 patients had minor residual adenomas that were treated successfully with snare resection and/or argon plasma coagulation.
  • CONCLUSION: EMR for large sporadic nonampullary duodenal adenomas is a safe and effective technique.
  • [MeSH-major] Adenoma / surgery. Duodenal Neoplasms / surgery. Duodenoscopy / methods. Intestinal Mucosa / surgery. Neoplasm Invasiveness / pathology

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  • (PMID = 18725157.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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95. Young PE, Gentry AB, Cash BD: The utility of flexible sigmoidoscopy after a computerized tomographic colonography revealing only rectosigmoid lesions. Aliment Pharmacol Ther; 2008 Mar 15;27(6):520-7
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  • Advanced lesions were defined as: adenocarcinoma, tubular adenoma >1 cm, > or =3 tubular adenomas, tubulovillous histology or high-grade dysplasia.

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  • (PMID = 18194507.001).
  • [ISSN] 1365-2036
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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96. Rea JD, Lockhart ME, Yarbrough DE, Leeth RR, Bledsoe SE, Clements RH: Approach to management of intussusception in adults: a new paradigm in the computed tomography era. Am Surg; 2007 Nov;73(11):1098-105
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  • Three had ileocolic disease, including cecal cancer (one), metastatic melanoma (one) and idiopathic (one; whereas five patients had colocolonic intussusception from colon cancer (three), tubulovillous adenoma (one), and local inflammation (one).

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  • (PMID = 18092641.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Kim DH, Pickhardt PJ, Taylor AJ: Characteristics of advanced adenomas detected at CT colonographic screening: implications for appropriate polyp size thresholds for polypectomy versus surveillance. AJR Am J Roentgenol; 2007 Apr;188(4):940-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characteristics of advanced adenomas detected at CT colonographic screening: implications for appropriate polyp size thresholds for polypectomy versus surveillance.
  • OBJECTIVE: Advanced adenomas are the primary target in colorectal screening.
  • The purpose of this study was to delineate the prevalence and imaging characteristics of advanced adenomas detected at screening CT colonography (CTC) and the rates of invasive carcinoma and high-grade dysplasia for various polyp size categories.
  • From this group, prevalence, size, histologic features, morphologic features, and location of advanced adenomas were tabulated.
  • Advanced adenomas were defined by size (> or = 10 mm) and/or histologic findings (prominent villous component or high-grade dysplasia).
  • RESULTS: A total of 123 (38.3%) of 321 adenomas measuring 6 mm or more were classified as advanced, the overall prevalence being 3.1% (111 of 3,536 patients).
  • The mean size of advanced adenomas was 16.6 +/- 11.6 mm; most of the lesions (116/123, 94.3%) qualified as advanced on the basis of the size criterion alone.
  • The seven lesions measuring 6-9 mm constituted 3.4% (7/205) of all medium-sized adenomas.
  • The largest percentage (65/123, 52.8%) of the advanced adenomas had tubular histologic features, followed by tubulovillous (50/123, 40.6%), villous (5/123, 4.1%), and serrated (3/123, 2.4%) histologic features.
  • The majority of advanced adenomas were classified as sessile (57/123, 46.3%) or pedunculated (57/123, 46.3%); a small percentage were flat (9/123, 7.3%).
  • Advanced adenomas were located in the proximal colon in 43.9% (54/123) and distal colon in 56.1% (69/123) of the cases.
  • CONCLUSION: Advanced adenomas were generally large (> or = 10 mm in size); only a small percentage were medium sized (6-9 mm).
  • [MeSH-major] Adenoma / radiography. Colonic Neoplasms / radiography. Colonic Polyps / radiography. Colonography, Computed Tomographic

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  • (PMID = 17377027.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Pisano C, Ottaiano A, Tatangelo F, Di Bonito M, Falanga M, Iaffaioli VR, Botti G, Pignata S, Acquaviva AM: Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas. Anticancer Res; 2005 May-Jun;25(3B):2065-8
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  • [Title] Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas.
  • MATERIALS AND METHODS: The expression of COX-2 was evaluated in 68 paraffin-embedded sporadic colorectal adenomas by immunohistochemistry.
  • Associations between COX-2 expression and the clinicopathological characteristics of the adenomas were studied by contingency tables and the Chi-square test.
  • RESULTS: Cytoplasmic staining for COX-2 protein was present in epithelial cells of 62 out of the 68 adenomas.
  • Furthermore, no significant correlations were found between the expression of the protein and histology (tubular vs tubulovillous), localization (proximal vs distal) or morphology (sessil vs pedunculated) of the adenomas.
  • Both stromal and epithelial COX-2 expressions were higher in larger (>4 mm) compared with smaller (< or =4 mm) adenomas (p =0.
  • CONCLUSION: These data support the hypothesis that the expression of COX-2 may occur as a general phenomenon in colorectal adenomas.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / pathology. Prostaglandin-Endoperoxide Synthases / biosynthesis

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  • (PMID = 16158946.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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99. Hansel DE, Rahman A, Wilentz RE, Shih IeM, McMaster MT, Yeo CJ, Maitra A: HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract. Int J Gastrointest Cancer; 2005;35(1):15-23
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  • In addition, we utilized the neoplastic progression model of colorectal cancer to evaluate HLA-G protein expression in normal colon, tubulovillous adenomas, invasive cancer, and liver metastases arising from colorectal cancer.
  • Specifically, tubulovillous adnenomas demonstrated pronounced diffuse labeling in 58% of lesions examined.

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  • (PMID = 15722570.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HLA Antigens; 0 / HLA-G Antigens; 0 / Histocompatibility Antigens Class I
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100. Ayhan S, Isisag A, Saruc M, Nese N, Demir MA, Kucukmetin NT: The role of pRB, p16 and cyclin D1 in colonic carcinogenesis. Hepatogastroenterology; 2010 Mar-Apr;57(98):251-6
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  • BACKGROUND/AIMS: This study is aimed to investigate abnormal expression of the Rb protein (pRb), p16(INK4a) (p16) and cyclin D1 in colorectal adenomas and adenocarcinomas and to assess the possible alterations in Rb pathway in colorectal carcinogenesis.
  • METHODOLOGY: 44 cases of colorectal adenoma and 44 cases of colorectal adenocarcinoma were examined histopathologically and immunohistochemically using monoclonal antibodies to identify abnormalities of pRb, p16, and cyclin D1 expression.
  • RESULTS: In 70.5% of the adenomas and 97.7% of the adenocarcinomas, an overexpression of pRb was found.
  • There was a statistically significant relationship between the immunoreactivity of pRb and villous/tubulovillous types of adenomas (p < 0.05).
  • There was a loss of p16 expression in 84.1% of adenomas and 61.4% of adenocarcinomas.
  • Statistically significantly, the p16 overexpression was not seen in any of tubular adenomas (p < 0.001).
  • Overexpression of cyclin D1 was found in only 9.1% of adenomas, while 31.8% of adenocarcinomas overexpressed this protein.
  • Loss of expression of cyclin D1 was similar in adenomas and adenocarcinomas (27.3% and 25%, respectively).
  • Staining degrees of all three cell cycle proteins were shown to be statistically different in adenomas and adenocarcinomas, for pRb (p = 0.001), for p16 ( p = 0.045), and cyclin D1 ( p = 0.05).
  • Also, there was only a mild agreement with respect to p16 and cyclin D1 relationship between for adenomas ( K = +0.28 p = 0.051) and for adenocarcinomas ( K = +0.35 p = 0.017).
  • CONCLUSIONS: pRb, p16 and cyclin D1 are shown to be aberrantly expressed in both colorectal adenomas and adenocarcinomas.
  • It can be claimed that disturbances in Rb pathway take part in colonic carcinogenesis and pRb, p16 and cyclin D1 play an ever increasing role in the further stages of adenoma-carcinoma sequence.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Cyclin D1 / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Retinoblastoma Protein / metabolism






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