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1. Bafandeh Y, Khoshbaten M, Eftekhar-Sadat AT, Farhang S: Colorectal neoplasms in symptomatic patients without evidence of bleeding: a prospective study in an Iranian population. Asian Pac J Cancer Prev; 2007 Oct-Dec;8(4):485-8
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  • The recruitment procedure involved 228 individuals aged more than 30 who visited a gastroenterologist because of lower gastrointestinal tract symptoms and had criteria for a colonoscopy.
  • Most of them were tubular (58.3%) and severe dysplasia was reported in only 3 cases (11.1%).
  • CONCLUSION: The low prevalence of colorectal neoplasms as well as the less advanced pattern of adenomas in Iran are compatible with other data from Asia and the Middle East, contrasting with western countries.
  • [MeSH-major] Adenoma / diagnosis. Colonic Polyps / diagnosis. Colorectal Neoplasms / diagnosis

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  • (PMID = 18260716.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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2. Yamaguchi Y, Hoshiya T, Horiguchi K, Tamura K: An occurrence of multiple carcinomas in both kidneys of a 5-year-old female cynomolgus monkey (Macaca fascicularis). Toxicol Pathol; 2007 Dec;35(7):1010-2
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  • [Title] An occurrence of multiple carcinomas in both kidneys of a 5-year-old female cynomolgus monkey (Macaca fascicularis).
  • An occurrence of multiple carcinoma in both kidneys of a 5-year-old female cynomolgus monkey is described in the present paper.
  • Electron microscopy revealed the existence of a brush border-like structure on the cell surface of carcinoma cells, suggesting that carcinoma cells arose from proximal tubular epithelial cells.
  • Small foci of tubular epithelial cell hyperplasia and adenomas were also observed independently of carcinomas.
  • There was no evidence of transition from adenoma to carcinoma, and no metastases were detected.
  • [MeSH-major] Carcinoma, Renal Cell / veterinary. Kidney Neoplasms / veterinary. Monkey Diseases / pathology

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  • (PMID = 18098046.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Zhang WW, Ren BJ, Tong HS, Zhang YL, Jiang P: [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 May;9(3):250-2
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  • [Title] [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases].
  • OBJECTIVE: To explore the endoscopic and histopathological morphology of large intestinal serrated adenomas (SA).
  • RESULTS: Forty-seven of the 71 serrated adenomas were protruded (sessile 23, semipedunculated 5, pedunculated 23) and 24 were superficial (flat 16, laterally spreading 8).
  • Histopathologically, SA contained tubular glands in 53, tubulovillous glands in 9 and villous glands in 9 cases.
  • Most IV and III L pit SAs presented villous glands (64%) and tubular glands (68%), respectively.
  • 40% of hyperplastic polyps-like SAs, composed of tubular glands,showed II pit pattern.
  • [MeSH-major] Adenoma / pathology. Colonoscopy. Colorectal Neoplasms / pathology

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  • (PMID = 16721690.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
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4. Platell C, Salama P, Barwood N, Makin G: Performing a colonoscopy 12 months after surgery for colorectal neoplasia. ANZ J Surg; 2005 May;75(5):282-5
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  • On histology, 42% were tubular adenomas, 6% tubulo-villous adenomas, 7% were villous adenomas, and 37% were hyperplastic.
  • Advanced adenomas were identified in 7.9% of patients (95% CI 4.8-12.1%).
  • CONCLUSION: We have observed a high prevalence of advanced adenomas in patients undergoing a 12-month, follow-up colonoscopy after curative surgery for colorectal neoplasia.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasms, Second Primary / diagnosis

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  • [CommentIn] ANZ J Surg. 2005 May;75(5):257-8 [15932431.001]
  • (PMID = 15932437.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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5. Kirimlioglu H, Kirimlioglu V, Yilmaz S, Sagir V, Coban S, Turkmen E, Hilmioglu F: Role of matrix metalloproteinase-7 in colorectal adenomas. Dig Dis Sci; 2006 Nov;51(11):2068-72
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  • [Title] Role of matrix metalloproteinase-7 in colorectal adenomas.
  • They are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas.
  • In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of colonic adenomas.
  • Although MMP-7 has already been shown to be overexpressed in various types of colonic adenomas, tubular versus villous adenomas had not been further seperated to date.
  • Seventy-six patients had either normal mucosa (n=15) or tubular (n=32), tubulovillous (n=16), or villous (n=13) colonic adenoma.
  • Each adenoma was graded according to the percentage of strongly stained areas in the adenoma as G0, G1, G2, or G3.
  • Sixty-nine percent of villous adenomas showed grade 3 staining of MMP-7, versus none of the tubular adenomas.
  • G0 and G1 staining was not detected in the villous adenomas.
  • The results of the study show that the degrees of overexpression of the three subtypes of colonic adenomas were statistically significantly different.
  • In conclusion, MMP-7 overexpression is thought to be an early event in the adenoma-carcinoma pathway.
  • [MeSH-major] Adenoma / enzymology. Colorectal Neoplasms / enzymology. Matrix Metalloproteinase 7 / physiology
  • [MeSH-minor] Adenoma, Villous / enzymology. Adenoma, Villous / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies

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  • (PMID = 17009118.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
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6. Lee S, Bang S, Song K, Lee I: Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon. Oncol Rep; 2006 Oct;16(4):747-54
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  • [Title] Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon.
  • The majority of colon cancers develop from pre-existing adenomas.
  • We analyzed the expression profiles in the sequence of normal colon crypts, adenomas and early-stage carcinomas using microdissected cells from tubular adenomas with foci of malignant transformation.
  • Differentially expressed genes were detected between normal-adenoma and adenoma-carcinoma, and were grouped according to the patterns of expression changes in the sequence.
  • TGF-beta2 and matrix metalloproteinase 23B were up-regulated in carcinoma but not in adenoma, supporting the pathobiological roles in malignant transformation.
  • Differentially expressed genes partly coincided with those in the adenoma-carcinoma sequence of the stomach, which was published previously, suggesting a partial overlap between the adenoma-carcinoma sequences of the colon and stomach.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Colonic Neoplasms / metabolism. Gene Expression Regulation. Gene Expression Regulation, Neoplastic

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  • (PMID = 16969489.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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7. Kaltenbach T, Friedland S, Soetikno R: A randomised tandem colonoscopy trial of narrow band imaging versus white light examination to compare neoplasia miss rates. Gut; 2008 Oct;57(10):1406-12
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  • Of the 135 patients in the NBI group, 17 patients (12.6%; 95% confidence interval (CI) 7.5 to 19.4%) had a missed neoplasm, as compared with 17 of the 141 patients (12.1%; 95% CI 7.2 to 18.6%) in the WL group, with a miss rate risk difference of 0.5% (95% CI -7.2 to 8.3).
  • All missed neoplasms were tubular adenomas, the majority (78%) was < or = 5 mm and none were larger than 1 cm (one-sided 95% CI up to 1%).
  • INTERPRETATION: NBI did not improve the colorectal neoplasm miss rate compared to WL; the miss rate for advanced adenomas was less than 1% and for all adenomas was 12%.
  • The neoplasm detection rates were similar high using NBI or WL; almost a half the study patients had at least one adenoma.

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  • (PMID = 18523025.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00628147
  • [Grant] United States / NIDDK NIH HHS / DK / T32 DK007056
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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8. Cobrin GM, Pittman RH, Lewis BS: Increased diagnostic yield of small bowel tumors with capsule endoscopy. Cancer; 2006 Jul 1;107(1):22-7
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  • METHODS: A retrospective analysis of the charts of 562 patients who underwent capsule endoscopy from August 2001 to November 2003 for a variety of indications was performed.
  • The types of tumor diagnosed by capsule endoscopy included 8 adenocarcinomas (1.4%), 10 carcinoids (1.8%), 4 gastrointestinal stromal tumors (0.7%), 5 lymphomas (0.9%), 3 inflammatory polyps, 1 lymphangioma, 1 lymphangioectasia,1 hemangioma, 1 hamartoma, and 1 tubular adenoma.
  • CONCLUSIONS: Capsule endoscopy diagnosed small bowel tumors in 8.9% of patients who underwent the procedure for a variety of reasons, establishing it as an effective diagnostic modality.

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  • [Copyright] Copyright 2006 American Cancer Society.
  • (PMID = 16736516.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Capsules
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9. Cheung C, Vesey D, Cotterill A, Douglas M, Gobe G, Nicol D, Johnson D: Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas. Int J Urol; 2005 Jan;12(1):17-28
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  • [Title] Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas.
  • BACKGROUND: The purpose of the present paper was to describe the pattern of expression of insulin-like growth factor (IGF-I) and its regulatory binding proteins (IGFBP) in renal cell carcinoma (RCC).
  • METHODS: The expressions of mRNA and protein for various IGF members were assessed in 24 paired normal and malignant human renal tissues (16 clear cell and 8 papillary RCC) using semiquantitative reverse transcription-polymerase chain reaction and immunohistochemistry.
  • Paired tissue samples were also obtained from six patients with oncocytoma in order to compare the specificity of changes in IGF/IGFBP expression between tumors derived from proximal (RCC) and distal (oncocytoma) tubular epithelium.
  • RESULTS: Clear cell RCC were characterized by significant increases in the mRNA expression of IGF-I, IGFBP-3 and IGFBP-6 while papillary RCC exhibited down-regulated expression of IGF-I, IGFBP-4 and IGFBP-5.
  • Semiquantitative assessment of immunohistochemical staining demonstrated significant increases in epithelial associated IGF-I and IGFBP-3 in clear cell RCC, increased IGFBP-5 protein in papillary RCC and no significant changes in IGF/IGFBP protein expression in oncocytoma.
  • This altered expression is differentially regulated according to the histologic subtype of RCC, and suggests that the IGF/IGFBP axis may play an important role in determining the malignant phenotype of RCC.
  • [MeSH-major] Adenocarcinoma, Clear Cell / metabolism. Carcinoma, Papillary / metabolism. Carcinoma, Renal Cell / metabolism. Insulin-Like Growth Factor I / metabolism. Kidney Neoplasms / metabolism. RNA, Messenger / metabolism
  • [MeSH-minor] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / metabolism. Down-Regulation. Female. Humans. Immunohistochemistry. Insulin-Like Growth Factor Binding Proteins / genetics. Insulin-Like Growth Factor Binding Proteins / metabolism. Male. Middle Aged. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15661050.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Insulin-Like Growth Factor Binding Proteins; 0 / RNA, Messenger; 67763-96-6 / Insulin-Like Growth Factor I
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10. Gollub MJ, Akhurst T, Markowitz AJ, Weiser MR, Guillem JG, Smith LM, Larson SM, Margulis AR: Combined CT colonography and 18F-FDG PET of colon polyps: potential technique for selective detection of cancer and precancerous lesions. AJR Am J Roentgenol; 2007 Jan;188(1):130-8
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  • PET depicted 23 of 39 premalignant polyps and even showed increased tracer activity associated with four small tubular adenomas (4-6 mm).
  • Sixteen benign polyps (10-25 mm) were not depicted on PET.
  • However, six benign flat polyps did not exhibit FDG avidity.

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  • (PMID = 17179355.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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11. Nandurkar D, Kalff V, Turlakow A, Spencer A, Bailey MJ, Kelly MJ: Focal MIBI uptake is a better indicator of active myeloma than diffuse uptake. Eur J Haematol; 2006 Feb;76(2):141-6
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  • A further 20 scans (10 subjects having MIBI myocardial perfusion scintigraphy and 10 subjects having MIBI parathyroid adenoma localisation studies), comprised the control (non-myeloma) cohort.
  • Scans were evaluated in a double-blinded fashion by two observers for any diffuse skeletal MIBI uptake (homogeneous uptake in spine, sternum and/or long bones), and/or abnormal focal uptake (patchy, focal or tubular uptake in the skeleton or soft tissues).

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  • (PMID = 16405435.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Nitriles; 0 / Organotechnetium Compounds; 109434-22-2 / 2-methoxyisobutylisonitrile
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12. Shen SS, Krishna B, Chirala R, Amato RJ, Truong LD: Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol; 2005 Jul;18(7):933-40
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  • Renal cell neoplasms are presumably derived from different cell types of the nephron.
  • Clear cell and papillary renal cell carcinoma (RCC) are thought to be of proximal tubular origin, whereas oncocytoma and chromophobe RCC are derived from intercalated cells of distal nephron.
  • A few molecules, such as RCC marker and CD10, have been shown to be markers for clear cell RCC and papillary RCC.
  • The expression of kidney-specific (Ksp) cadherin, a recently cloned gene thought to be transcribed exclusively in the kidney, was studied in normal human kidney, as well as in 105 primary renal neoplasms, including 42 clear cell RCC, 30 papillary RCC, 13 chromophobe RCC, and 20 oncocytomas.
  • All 13 chromophobe RCC and 19 of 20 oncocytomas showed diffuse and strong immunoreactivity for Ksp-cadherin, while only 14% clear cell RCC and 13% papillary RCC showed focal positivity.
  • The RCC marker expression was detected in 85%, 98%, 15% and 0% of clear cell RCC, papillary RCC, chromophobe RCC, and oncocytoma, respectively.
  • A few clear cell RCC and papillary RCC showed dual expression of both RCC marker and Ksp-cadherin, which appear to have distinct histologic features.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Biomarkers / analysis. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Kidney Tubules / chemistry

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  • (PMID = 15696118.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cadherins; 0 / FAT1 protein, human
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13. Calderaro J, Bayou EH, Castaigne D, Mathieu MC, Andreiuolo F, Suciu V, Delaloge S, Vielh P: Tubular adenoma of the breast with associated mucinous features: a cytological diagnostic trap. Cytopathology; 2010 Jun;21(3):191-3
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  • [Title] Tubular adenoma of the breast with associated mucinous features: a cytological diagnostic trap.

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  • (PMID = 19456846.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Mucins
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14. Sohn JW, Jeon SW, Cho CM, Jung MK, Kim SK, Lee DS, Son HS, Chung IK: Endoscopic resection of duodenal neoplasms: a single-center study. Surg Endosc; 2010 Dec;24(12):3195-200
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  • BACKGROUND: Premalignant duodenal lesions such as adenomas are rare.
  • METHODS: Patients with nonampullary duodenal adenomas or duodenal adenocarcinomas without familial polyposis syndrome between August 2002 and February 2009 were retrospectively analyzed.
  • Of these patients, 23 had duodenal adenomas and 1 had an adenocarcinoma confined to the mucosa.
  • Tubular adenomas were the most common type (17/24, 70.8%).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Duodenal Neoplasms / surgery. Duodenoscopy

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  • (PMID = 20490557.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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15. Ohike N, Kim GE, Tajiri T, Krasinskas A, Basturk O, Coban I, Bandyopadhyay S, Morohoshi T, Goodman M, Kooby DA, Sarmiento JM, Adsay NV: Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases. Am J Surg Pathol; 2010 Dec;34(12):1731-48
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  • [Title] Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases.
  • Here, we provide a detailed analysis of these neoplasms, which we propose to refer to as intra-ampullary papillary-tubular neoplasm (IAPN).
  • (1) Clinical: The mean age was 64 years, male/female ratio was 2.4, and mean tumor size was 2.7 cm. (2) Pathology: The tumors had a mixture of both papillary and tubular growth (each constituting at least 25% of the lesion) in 57%; predominantly (>75%) papillary in 23%, and predominantly (>75%) tubular in 20%.
  • In terms of cell-lineage morphology, 45% had a mixture of patterns.
  • However, when evaluated with a forced-binary approach as intestinal (INT) versus gastric/pancreatobiliary (GPB) based on the predominant pattern, 74% were classified as INT and 26% as GPB. (3) Immunohistochemistry: Percent sensitivity/specificity of cell-lineage markers were, for INT phenotype: MUC2 85/78 and CDX2 94/61; and for GBP: MUC1 89/79, MUC5AC 95/69, and MUC6 83/76, respectively.
  • Cell lineage in the invasive component was the same as that of the preinvasive component in 84%.
  • CONCLUSIONS: Tumoral intraepithelial neoplasia occurring within the ampulla are highly analogous to pancreatic or biliary intraductal papillary and tubular neoplasms as evidenced by their papillary and/or tubular growth, variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence), and thus we propose to refer to these as IAPN.

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  • (PMID = 21084962.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P20 CA101936; United States / NCI NIH HHS / CA / P50 CA062924; United States / NCI NIH HHS / CA / P50 CA062924-18; United States / NCI NIH HHS / CA / CA101936
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS315774; NLM/ PMC3168573
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16. Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D: Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. Acta Dermatovenerol Croat; 2007;15(3):148-51
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  • [Title] Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.
  • A case of a 79-year-old woman with axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia is presented.
  • In one area, the tumor was lobular and composed of tubular structures lined with one layer of uniform cuboidal or columnar eosinophilic cells, indicating a pre-existing apocrine adenoma.
  • This and previously reported cases suggest that apocrine hyperplasia and apocrine adenoma may represent successive steps in the development of apocrine carcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17868540.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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17. Boolchand V, Olds G, Singh J, Singh P, Chak A, Cooper GS: Colorectal screening after polypectomy: a national survey study of primary care physicians. Ann Intern Med; 2006 Nov 7;145(9):654-9
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  • MEASUREMENTS: Physicians were asked when they would recommend repeated colonoscopy for a hypothetical 55-year-old man with no family history of colorectal cancer after the following 6 results on colonoscopy: hyperplastic polyp, one 6-mm tubular adenoma, two 6-mm tubular adenomas, one 12-mm tubulovillous adenoma, one 12-mm tubular adenoma with focal high-grade dysplasia, and no polyp but a previous tubular adenoma.
  • Sixty-one percent of respondents would survey a hyperplastic polyp in 5 years or less, 71% would survey a single tubular adenoma in 3 years or less, and 80% would survey 2 tubular adenomas in 3 years or less.
  • CONCLUSION: Primary care physicians recommend postpolypectomy colonoscopic surveillance more frequently than is recommended by practice guidelines, especially if the colonoscopy showed a hyperplastic polyp or a single small adenoma.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / surgery. Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Cross-Sectional Studies. Female. Follow-Up Studies. Guideline Adherence. Humans. Hyperplasia / diagnosis. Hyperplasia / surgery. Male. Middle Aged. Practice Guidelines as Topic. Risk Factors. Surveys and Questionnaires. Time Factors. United States


18. Bartley AN, Thompson PA, Buckmeier JA, Kepler CY, Hsu CH, Snyder MS, Lance P, Bhattacharyya A, Hamilton SR: Expression of gastric pyloric mucin, MUC6, in colorectal serrated polyps. Mod Pathol; 2010 Feb;23(2):169-76
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  • A previous study reported that the expression of gastric pyloric-type mucin, MUC6, characterized sessile serrated adenomas.
  • We carried out immunohistochemistry for MUC6 on 146 serrated lesions and 87 conventional tubular adenomas, and assessed the percentage of cells with expression and the grade of staining intensity.
  • In all 92 hyperplastic polyps, 43 sessile serrated adenomas, and 11 traditional serrated adenomas were included.
  • The association of MUC6 staining with serrated polyp category was evaluated using classification and regression tree (CART) analysis and two-sided Fisher's exact test.
  • A total of 53% of sessile serrated adenomas (n=23), 17% of hyperplastic polyps (n=16), and 18% of traditional serrated adenomas (n=2), but none of 87 tubular adenomas, expressed MUC6.
  • MUC6 expression had relatively high specificity for sessile serrated adenoma (82%) but low sensitivity (54%).
  • In CART analysis, proximal location was found to be the best partitioning factor for MUC6, followed by classification as sessile serrated adenoma.
  • We conclude that MUC6 expression is strongly associated with proximal location of serrated polyps, but only has modest utility as a tissue biomarker for sessile serrated adenoma.

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  • (PMID = 19855374.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA023074; United States / NCI NIH HHS / CA / CA-41108; United States / NCI NIH HHS / CA / P01 CA041108; United States / NCI NIH HHS / CA / CA023074; United States / NCI NIH HHS / CA / P01 CA041108-13; United States / NCI NIH HHS / CA / CA041108-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC6 protein, human; 0 / Mucin-6
  • [Other-IDs] NLM/ NIHMS146119; NLM/ PMC2818151
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19. Toruner M, Harewood GC, Loftus EV Jr, Sandborn WJ, Tremaine WJ, Faubion WA, Schroeder KW, Egan LJ: Endoscopic factors in the diagnosis of colorectal dysplasia in chronic inflammatory bowel disease. Inflamm Bowel Dis; 2005 May;11(5):428-34
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  • BACKGROUND: Surveillance colonoscopy in inflammatory bowel diseases (IBDs) is advocated for early diagnosis of neoplasia but is imperfect because some patients develop cancer despite surveillance.
  • In 28 patients (4.4%), sporadic tubular adenoma was identified.
  • [MeSH-major] Colon / pathology. Colonoscopy. Colorectal Neoplasms / etiology. Inflammatory Bowel Diseases / pathology


20. Michal M, Hes O, Nemcova J, Sima R, Kuroda N, Bulimbasic S, Franco M, Sakaida N, Danis D, Kazakov DV, Ohe C, Hora M: Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity. Virchows Arch; 2009 Jan;454(1):89-99
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  • [Title] Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity.
  • We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT).
  • The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma.
  • Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts.
  • All tubular/glandular structures were lined by a fine capillary network.
  • RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology

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  • (PMID = 19020896.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / Keratin-20; 0 / Keratin-7; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins; EC 2.3.2.27 / Von Hippel-Lindau Tumor Suppressor Protein; EC 6.3.2.- / VHL protein, human
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21. Assenza M, Ricci G, Antoniozzi A, Martines V, Valesini L, Romeo V, Modini C: Sigmoidorectal intussusception in adults: a case report. Clin Ter; 2010;161(1):65-7
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  • Histopathological examination demonstrated a tubular adenoma with low grade dysplasia, 1,2 cm in diameter, located in the distal sigmoid colon.
  • In children it is usually primary and benign, and pneumatic or hydrostatic reduction of the intussusception is sufficient to treat the condition in 80% of patients.
  • [MeSH-major] Adenoma / diagnosis. Intussusception / surgery. Rectal Diseases / diagnosis. Sigmoid Neoplasms / diagnosis

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  • (PMID = 20393683.001).
  • [ISSN] 1972-6007
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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22. Chlumská A, Boudová L, Zámecník M: Sessile serrated adenomas of the large bowel. Clinicopathologic and immunohistochemical study including comparison with common hyperplastic polyps and adenomas. Cesk Patol; 2006 Jul;42(3):133-8
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  • [Title] Sessile serrated adenomas of the large bowel. Clinicopathologic and immunohistochemical study including comparison with common hyperplastic polyps and adenomas.
  • Sessile serrated adenoma (SSA) is a newly characterized type of the large bowel adenoma.
  • For comparison, we examined 10 conventional tubular adenomas and 10 common HPs with vesicular cells.
  • However, our study found positivity of MUC2 and MUC5A also in conventional adenomas.
  • SSAs have malignant potential comparable with conventional adenomas and for this reason they must be distinguished from HPs.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Intestinal Polyps / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16955561.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins
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23. Al-Daraji WI, Abdellaoui A, Salman WD: Osseous metaplasia in a tubular adenoma of the colon. J Clin Pathol; 2005 Feb;58(2):220-1
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  • [Title] Osseous metaplasia in a tubular adenoma of the colon.
  • The polyp was a tubular adenoma with mild dysplasia.
  • The adenoma contained numerous foci of metaplastic bone.
  • This is the first case of osseous metaplasia in a tubular adenoma of the colon to be reported.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Ossification, Heterotopic / pathology

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  • [Cites] Gastrointest Endosc. 1981 Aug;27(3):198-9 [7297837.001]
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  • (PMID = 15677548.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770563
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24. Rao Q, Liu XH, Zhou HB, Ma HH, Lu ZF, Zhou XJ: Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas. Tumori; 2010 Mar-Apr;96(2):304-9
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  • [Title] Expression analysis of Wnt-5a in renal epithelial neoplasms: distinguishing renal oncocytoma from a wide spectrum of renal cell carcinomas.
  • OBJECTIVE: To study the expression of a novel marker, Wnt-5a, in renal epithelial neoplasms and determine its clinicopathological significance.
  • METHODS: Immunohistochemical analysis of Wnt-5a was carried out in normal human kidney samples as well as in 123 primary renal epithelial neoplasms including 37 clear cell renal cell carcinomas (RCCs), 24 papillary RCCs (15 type 1 and 9 type 2), 25 chromophobe RCCs, 11 Xp11 translocation carcinomas, 6 mucinous tubular and spindle cell carcinomas, and 20 oncocytomas.
  • RESULTS: Wnt-5a was expressed in 18.9% (7/37) of clear cell RCCs, 12.5% (3/24) of papillary RCCs, 16% (4/25) of chromophobe RCCs, 18.2% (2/11) of Xp11 translocation carcinomas, 0% (0/6) of mucinous tubular and spindle cell carcinomas, and 100% (20/20) of oncocytomas.
  • [MeSH-major] Adenoma, Oxyphilic / chemistry. Carcinoma, Renal Cell / chemistry. Kidney Neoplasms / chemistry. Neoplasms, Glandular and Epithelial / chemistry. Proto-Oncogene Proteins / analysis. Wnt Proteins / analysis

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  • (PMID = 20572590.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / WNT5A protein, human; 0 / Wnt Proteins; 0 / Wnt-5a Protein
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25. Chu PG, Lau SK, Weiss LM, Jiang Z: Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney. Virchows Arch; 2009 Oct;455(4):389-94
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  • In areas, the mucinous epithelium showed complex proliferation with stratification, papillae formation, and nuclear atypia, resembling that of an ovarian mucinous borderline tumor, a colorectal tubular adenoma, or a low-grade appendiceal mucinous carcinoma.

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  • [Cites] J Urol. 2001 Oct;166(4):1381-2 [11547080.001]
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  • (PMID = 19756727.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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26. Matthiessen MW, Pedersen G, Albrektsen T, Adamsen S, Fleckner J, Brynskov J: Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. Scand J Gastroenterol; 2005 Feb;40(2):198-205
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  • [Title] Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas.
  • OBJECTIVE: Peroxisome proliferator-activated receptor (PPAR) ligands, widely used in type 2 diabetes treatment, have variably been shown to promote or prevent colon tumor formation in animal models and cell lines, but their role in normal human colon is unknown.
  • The aim of this study was to determine PPAR expression and function in normal human colonic epithelial cells and tubular adenomas.
  • Cell viability was measured using the methyltetrazoleum assay, proliferation by thymidine incorporation, and DNA profiles by flow cytometry.
  • PPAR mRNA levels in tubular adenomas or metaplastic polyps (n=12) were compared with those in controls.
  • PPAR gamma activation had no effect on viability or DNA profiles, but led to a 25% significant decrease in cell proliferation.
  • Finally, a selective and significant 2.5-fold decrease in PPAR alpha expression was observed in tubular adenomas, but not in metaplastic polyps, compared to controls.
  • Moreover, they raise interest in investigation of PPAR alpha as a therapeutic target to prevent adenoma formation.
  • [MeSH-major] Adenoma / metabolism. Colonic Neoplasms / metabolism. Epithelial Cells / metabolism. Peroxisome Proliferator-Activated Receptors / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Cell Survival / physiology. Colon. Female. Humans. Male. Middle Aged

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  • (PMID = 15764152.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Peroxisome Proliferator-Activated Receptors
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27. Yang HY, Ge ZZ, Dai J, Li XB, Gao YJ: [The effect of immunofecal occult blood test on colorectal cancer screening]. Zhonghua Nei Ke Za Zhi; 2008 Aug;47(8):642-5
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  • 94 cases (16.01 per thousand) of adenomatous polyps were found including 55 cases (58.51%) of tubular adenoma, 23 cases (24.47%) of villiform-tubular adenoma and 16 cases (17.02%) of villiform adenoma.

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  • (PMID = 19080296.001).
  • [ISSN] 0578-1426
  • [Journal-full-title] Zhonghua nei ke za zhi
  • [ISO-abbreviation] Zhonghua Nei Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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28. Goodden JR, Marven SS, Cohen M, de Ville McMullan PJ, Smith MF: Congenital apocrine tumour: a rare scalp tumour. Eur J Pediatr Surg; 2008 Aug;18(4):282-4
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  • We report a rare congenital scalp tumour with histological diagnosis of a congenital apocrine adenoma with features of a tubular adenoma.

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  • (PMID = 18629773.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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29. Skinnider BF, Folpe AL, Hennigar RA, Lim SD, Cohen C, Tamboli P, Young A, de Peralta-Venturina M, Amin MB: Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. Am J Surg Pathol; 2005 Jun;29(6):747-54
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  • [Title] Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors.
  • Individual cases can show overlapping morphologic features, necessitating the use of ancillary methods.
  • The purpose of this study was to determine the diagnostic utility of cytokeratin (CK) subtype expression pattern in a wide range of adult RENs.
  • RENs (including clear cell [conventional] renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, renal oncocytoma, collecting duct carcinoma (CDC), renal medullary carcinoma (RMC), urothelial carcinoma, metanephric adenoma (MA), tubulocystic carcinoma (TC) (also known as low-grade collecting duct carcinoma), and mucinous tubular and spindle cell carcinoma) were immunostained for CK subtypes (CK5/CK6, 7, 8, 13, 14, 17, 18, 19, 20), high molecular weight CKs 1, 5, 10, 14 (HMWCK), and vimentin (Vim).
  • Clear cell RCCs typically showed a restricted expression pattern of CK8, CK18 and Vim.

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  • [CommentIn] Am J Surg Pathol. 2006 Oct;30(10):1337 [17001169.001]
  • (PMID = 15897741.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vimentin; 68238-35-7 / Keratins
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30. Ishiguro K, Yoshida T, Yagishita H, Numata Y, Okayasu T: Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas. Gut; 2006 May;55(5):695-702
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  • [Title] Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas.
  • Considering the established adenoma-adenocarcinoma sequence, in this study we analysed genetic instability in colorectal adenoma cells and surrounding stroma.
  • METHODS: In 164 colorectal tumours (34 hyperplastic polyps, 38 tubular adenomas with low grade dysplasia (TA-L), 51 tubular adenomas with high grade dysplasia (TA-H), and 41 invasive carcinomas), epithelial and stromal genetic instability with National Cancer Institute standard microsatellite markers and chromosome 17 (Chr17) markers, were analysed by a combination of laser capture microdissection and GeneScan approaches.
  • RESULTS: While frequencies of both loss of heterozygosity (LOH) and microsatellite instability (MSI) were extremely low in hyperplastic polyps, LOH in tubular adenomas was detected in both epithelial (TA-L 13.2%, TA-H 27.5%) and stromal (5.3% and 5.9%, respectively) elements, along with MSI (5.3% and 13.7%, and 5.3 and 5.9%, respectively).
  • On the other hand, frequencies of stromal LOH or MSI were almost constant (5.3% approximately 17.1%, 5.3% approximately 17.1%, respectively) in adenomas and invasive carcinomas.
  • Thus microenvironmental changes due to genetic alteration in Chr17 markers in stromal cells may play an important role in colon adenoma and adenocarcinoma development.
  • [MeSH-major] Adenoma / genetics. Biomarkers, Tumor / analysis. Chromosomes, Human, Pair 17. Colorectal Neoplasms / genetics. Gene Expression Regulation, Neoplastic. Genomic Instability

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  • (PMID = 16354798.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC1856111
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31. Lee SD: [Immunohistochemical analysis of nuclear factor, p38, and cyclin D1 proteins in premalignant lesions and carcinomas of the colorectal mucosa]. Korean J Gastroenterol; 2008 Dec;52(6):359-67
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  • BACKGROUND/AIMS: Nuclear factor-kappaB p65 (NF-kappaB p65), nuclear factor-kappaB1 p50 (NF-kappaB p50) have been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis.
  • METHODS: Paraffin sections of 20 normal mucosa, 20 low-grade tubular adenoma, 20 high-grade tubular adenoma and 64 adenocarcinoma tissues were analysed immunohistochemically for the expression of NF-kappaB p65, NF-kappaB p50, p38 MAPKalpha, and cyclin D1 proteins.
  • RESULTS: The expression of NF-kappaB p65, NF-kappaB p50, and p38 MAPKalpha proteins were significantly higher in adenocarcinoma tissue in comparison with that in normal mucosa, low-grade tubular adenoma, and high-grade tubular adenoma tissues.

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  • (PMID = 19096253.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / NF-kappa B p50 Subunit; 0 / Transcription Factor RelA; 136601-57-5 / Cyclin D1; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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32. Koizumi M, Sata N, Yoshizawa K, Kurihara K, Yasuda Y: Carcinoma Arising from Brunner's Gland in the Duodenum after 17 Years of Observation - A Case Report and Literature Review. Case Rep Gastroenterol; 2007;1(1):103-9
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  • Esophagogastroduodenoscopy (EGD) detected a small protruding lesion in the duodenal bulb, which was diagnosed as Brunner's adenoma.
  • Histopathological assessment showed acidophilic cells with swollen nuclei, and clear cells forming a tubular or papillary tubule in the mucosal lamina propria and submucosal layer.

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  • (PMID = 21487554.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3073796
  • [Keywords] NOTNLM ; Adenocarcinoma / Brunner's gland / Duodenal cancer
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33. Martinelli PT, Cohen PR, Schulze KE, Tschen JA, Nelson BR: Mohs micrographic surgery for tubular apocrine adenoma. Int J Dermatol; 2006 Nov;45(11):1377-8
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  • [Title] Mohs micrographic surgery for tubular apocrine adenoma.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Apocrine Glands / surgery. Mohs Surgery. Sweat Gland Neoplasms / surgery

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  • (PMID = 17076735.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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34. Buso AG, Rocha HL, Diogo DM, Diogo PM, Diogo-Filho A: Seroprevalence of Helicobacter pylori in patients with colon adenomas in a Brazilian university hospital. Arq Gastroenterol; 2009 Apr-Jun;46(2):97-101
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  • [Title] Seroprevalence of Helicobacter pylori in patients with colon adenomas in a Brazilian university hospital.
  • OBJECTIVE: To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal.
  • METHODS: After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls).
  • The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038).
  • CONCLUSION: There is a positive association between H. pylori infection and colonic adenomas.
  • This association is more evident in women, especially for tubular adenomas and distal colonic location.
  • [MeSH-major] Adenoma / microbiology. Colonic Neoplasms / microbiology. Helicobacter Infections / epidemiology. Helicobacter pylori

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  • (PMID = 19578608.001).
  • [ISSN] 1678-4219
  • [Journal-full-title] Arquivos de gastroenterologia
  • [ISO-abbreviation] Arq Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Biomarkers; 0 / Immunoglobulin G
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35. Saito Y, Uraoka T, Yamaguchi Y, Hotta K, Sakamoto N, Ikematsu H, Fukuzawa M, Kobayashi N, Nasu J, Michida T, Yoshida S, Ikehara H, Otake Y, Nakajima T, Matsuda T, Saito D: A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video). Gastrointest Endosc; 2010 Dec;72(6):1217-25
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  • MAIN OUTCOME MEASUREMENTS: Tumor size, macroscopic type, histology, procedure time, en bloc and curative resection rates and complications.
  • RESULTS: Included in the 1111 tumors were 356 tubular adenomas, 519 intramucosal cancers, 112 superficial submucosal (SM) cancers, 101 SM deep cancers, 18 carcinoid tumors, 1 mucosa-associated lymphoid tissue lymphoma, and 4 serrated lesions.
  • The en bloc and curative resection rates were 88% and 89%, respectively.
  • CONCLUSIONS: ESD performed by experienced endoscopists is an effective alternative treatment to surgery, providing high en bloc and curative resection rates for large superficial colorectal tumors.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Cohort Studies. Female. Follow-Up Studies. Humans. Intestinal Perforation / etiology. Intestinal Perforation / surgery. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, B-Cell, Marginal Zone / surgery. Male. Middle Aged. Postoperative Complications / etiology. Postoperative Hemorrhage / etiology. Postoperative Hemorrhage / surgery. Prospective Studies. Reoperation. Risk Factors

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  • [Copyright] Copyright © 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • [CommentIn] Nat Rev Gastroenterol Hepatol. 2011 Jan;8(1):5 [21268296.001]
  • (PMID = 21030017.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Video-Audio Media
  • [Publication-country] United States
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36. Uriev L, Maslovsky I, Vainshtein P, Yoffe B, Ben-Dor D: Malignant phyllodes tumor with heterologous liposarcomatous differentiation and tubular adenoma-like epithelial component. Int J Med Sci; 2006;3(4):130-4
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  • [Title] Malignant phyllodes tumor with heterologous liposarcomatous differentiation and tubular adenoma-like epithelial component.
  • A 30-year-old woman presented with a 1-year history of a palpable, asymptomatic right breast mass without axillary lymphadenopathy and family history of breast carcinoma.
  • The authors present not previously described histological appearance of this tumor where an epithelial component was identical to that of a tubular adenoma of the breast, with the review of the literature.

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  • (PMID = 17003843.001).
  • [ISSN] 1449-1907
  • [Journal-full-title] International journal of medical sciences
  • [ISO-abbreviation] Int J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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37. Muthukrishnan J, Hari Kumar KV, Jha R, Jha S, Modi KD: Distal renal tubular acidosis due to primary hyperparathyroidism. Endocr Pract; 2008 Dec;14(9):1133-6
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  • [Title] Distal renal tubular acidosis due to primary hyperparathyroidism.
  • OBJECTIVE: To present 4 cases of distal renal tubular acidosis (RTA) in patients with primary hyperparathyroidism (PHPT) and discuss their possible etiopathogenetic correlation.
  • Complete resolution of distal RTA was documented after surgical cure of PHPT by removal of a parathyroid adenoma.
  • CONCLUSION: Hypercalciuria in PHPT can lead to nephrocalcinosis and renal tubular dysfunction, which manifests as distal RTA.
  • [MeSH-major] Acidosis, Renal Tubular / etiology. Hyperparathyroidism, Primary / complications
  • [MeSH-minor] Adolescent. Adult. Bone Diseases / diagnosis. Bone Diseases / etiology. Female. Humans. Male. Middle Aged. Muscular Diseases / diagnosis. Muscular Diseases / etiology. Young Adult


38. Goto M, Yuen S, Nishimura T: MR imaging of tubular adenoma of breast associated with lactating change. Breast J; 2009 Sep-Oct;15(5):536-7
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  • [Title] MR imaging of tubular adenoma of breast associated with lactating change.

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  • (PMID = 19671118.001).
  • [ISSN] 1524-4741
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TA: Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology; 2010 Sep;139(3):869-81, 881.e1-9
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  • RESULTS: Compared with wild-type, I-pik3r1KO mice had reduced T-cell-mediated Akt and beta-catenin signaling in intestinal stem and progenitor cells and limited crypt epithelial proliferation.
  • PI3K inhibition in interleukin-10(-/-) mice impaired colitis-induced epithelial Akt and beta-catenin activation, reduced progenitor cell expansion, and prevented dysplasia.
  • Human samples had increased numbers of progenitor cells with P-beta-catenin(552) throughout expanded crypts and increased messenger RNA expression of beta-catenin target genes in CUC, colitis-associated cancer, tubular adenomas, and sporadic colorectal cancer, compared with control samples.
  • PI3K-induced and Akt-mediated beta-catenin signaling are required for progenitor cell activation during the progression from CUC to CAC; these factors might be used as biomarkers of dysplastic transformation in the colon.

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20580720.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK066161; United States / PHS HHS / / DKAI061701; United States / NIDDK NIH HHS / DK / R01 DK054778; United States / NIDDK NIH HHS / DK / DK54778; United States / NIAID NIH HHS / AI / AI061701-05; United States / NIDDK NIH HHS / DK / R01 DK054778-10; United States / NIDDK NIH HHS / DK / R01 DK047073; United States / NIDDK NIH HHS / DK / K08 DK066161; United States / NIDDK NIH HHS / DK / R01 DK047073-10; United States / NIAID NIH HHS / AI / R01 AI061701; United States / NIDDK NIH HHS / DK / DK054778-10; United States / NIAID NIH HHS / AI / R01 AI061701-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / CTNNB1 protein, mouse; 0 / Protein Kinase Inhibitors; 0 / Wnt Proteins; 0 / beta Catenin; 130068-27-8 / Interleukin-10; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  • [Other-IDs] NLM/ NIHMS210070; NLM/ PMC2930080
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40. Yamada T, Tamura S, Onishi S, Hiroi M: A comparison of magnifying chromoendoscopy versus histopathology of forceps biopsy specimen in the diagnosis of minute flat adenoma of the colon. Dig Dis Sci; 2009 Sep;54(9):2002-8
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  • [Title] A comparison of magnifying chromoendoscopy versus histopathology of forceps biopsy specimen in the diagnosis of minute flat adenoma of the colon.
  • Having noted a discrepancy between endoscopic and histopathological diagnoses in cases of minute adenomas of the colon, a prospective study was designed to clarify which is appropriate, magnifying chromoendoscopy or histopathology of a specimen obtained by biopsy forceps.
  • We separated the detected lesions with type III(L) pit pattern following Kudo's classification into two groups at random: in group A (n = 104) resected specimens were fixed with 20% buffered formalin without being flattened, whereas in group B (n = 104) the resected specimens were flattened using forceps before fixation and the specimens were cut under observation of their surface structure with stereomicroscopy.
  • Comparison of the initial diagnoses between groups A and B showed that a total of 84.6% (88/104) of the lesions were diagnosed to be tubular adenomas histopathologically in group A, compared with 100% (104/104) in group B (P < 0.0001).
  • Results for comparison of the secondary diagnoses between group A and group B showed that 14 of the 16 lesions were diagnosed as tubular adenomas histopathologically.
  • Thereafter, 98.1% (102/104) of the lesions were diagnosed to be tubular adenomas histopathologically in group A (P = 0.4976).
  • In conclusion, high-resolution magnifying chromoendoscopy is an appropriate procedure for the diagnosis of minute adenomas in comparison with histopathology of specimens obtained by biopsy forceps in this prospective study.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Colonoscopy / methods

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  • (PMID = 19037726.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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41. Cossu-Rocca P, Contini M, Brunelli M, Festa A, Pili F, Gobbo S, Eccher A, Mura A, Massarelli G, Martignoni G: S-100A1 is a reliable marker in distinguishing nephrogenic adenoma from prostatic adenocarcinoma. Am J Surg Pathol; 2009 Jul;33(7):1031-6
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  • [Title] S-100A1 is a reliable marker in distinguishing nephrogenic adenoma from prostatic adenocarcinoma.
  • Nephrogenic adenoma is a benign lesion that may occur at any site of the genitourinary tract, usually in association with previous urothelial injuries.
  • Although its pathogenesis is still debated, recent studies seem to confirm its derivation from renal tubular epithelium, rather than from a metaplastic process of urothelium.
  • In addition to its uncertain origin, there can be diagnostic difficulty in distinguishing nephrogenic adenoma from prostatic adenocarcinoma, particularly with lesions arising in the prostatic urethra.
  • S100A1 is a calcium binding protein that has been recently reported to be expressed in renal tubular cells and in a subset of renal cell neoplasms.
  • In this study, we investigated the expression of S100A1 and AMACR in 18 nephrogenic adenomas and in 100 prostatic adenocarcinomas.
  • A strong and distinct cytoplasmic or nucleocytoplasmic staining of S100A1 was found in 17 out of 18 cases of nephrogenic adenoma (94%), but never in prostatic adenocarcinoma.
  • In contrast, AMACR expression was detected in 14 of 18 nephrogenic adenomas (78%) and in 96 of 100 prostatic adenocarcinomas (96%).
  • We conclude that (1) S100A1 is a specific and sensitive immunohistochemical marker to differentiate nephrogenic adenoma from prostatic adenocarcinoma;.
  • (3) given that both S100A1 and AMACR have been reported to be expressed in renal tubular cells and in a subset of renal cell neoplasms, our findings confirm the histogenetic relationship between nephrogenic adenoma and renal tubular epithelium.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Prostatic Neoplasms / diagnosis. S100 Proteins / biosynthesis. Urogenital Neoplasms / diagnosis

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  • (PMID = 19384190.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / S100A1 protein; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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42. Zaman L, Bebb JR, Dunlop SP, Jobling JC, Teahon K: Familial colonic varices--a cause of "polyposis" on barium enema. Br J Radiol; 2008 Jan;81(961):e17-9
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  • She bled significantly after polypectomy of a tubular adenoma.

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  • (PMID = 18079346.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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43. Khder SA, Trifan A, Danciu M, Stanciu C: [Colorectal polyps: clinical, endoscopic, and histopathologic features]. Rev Med Chir Soc Med Nat Iasi; 2008 Jan-Mar;112(1):59-65
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  • The number, size, gross endoscopic appearance, histopathological examination, and the anatomic location of colorectal polyps were analyzed, as well as the associated diseases.
  • Based on the histological structural configuration, 76.5% of all polyps were adenomas, and of these 62.6% were tubular adenomas; malignant polyps have been diagnosed in 82 (5.4%) patients.
  • Most of polyps were identified in patients older than 50 years, predominantly men, located in distal colon, had a tubular adenoma histological structure, and frequently associated with hemorrhoids and diverticular disease.
  • [MeSH-minor] Adenoma / diagnosis. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Romania / epidemiology. Treatment Outcome

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  • (PMID = 18677904.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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44. Tabuchi M, Kitayama J, Nagawa H: Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men. World J Gastroenterol; 2006 Feb 28;12(8):1261-4
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  • [Title] Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men.
  • METHODS: We performed a large scale retrospective study to analyze the correlation between the incidence of colorectal adenoma or carcinoma and the fasting serum levels of total cholesterol (TC) and triglycerides (TG) in patients who underwent total colonoscopy for screening for colon cancer.
  • RESULTS: Both levels were significantly elevated in patients with adenomas as compared with patients without any neoplastic lesion (TC 207.6+/-29.5 vs 199.5+/-34.3, n=4883, P<0.001; TG 135.0+/-82.2 vs 108.7+/-71.5, n=4874, P<0.001).
  • The difference was significant in patients with tubular adenoma but not in those with villous or serrated adenoma.
  • The level of TG in patients with invasive carcinoma did not show a significant elevation from that in patients with adenoma.
  • These findings suggest that hypertriglyceridemia is an independent risk factor for colonic adenoma in men.
  • [MeSH-major] Adenoma / blood. Adenoma / etiology. Colorectal Neoplasms / blood. Colorectal Neoplasms / etiology. Hypertriglyceridemia / complications

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  • (PMID = 16534881.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
  • [Other-IDs] NLM/ PMC4124439
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45. Kaklamanis L, Trichas M, Amarantidis K, Spathari N, Micheli A, Karayiannakis A, Chatzaki E, Georgoulias V, Kakolyris S: VEGF expression in the colorectal adenoma-carcinoma sequence. Oncol Res; 2006;15(9):445-51
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  • [Title] VEGF expression in the colorectal adenoma-carcinoma sequence.
  • VEGF and p53 expression were evaluated in 16 hyperplastic polyps, 35 solitary tubular and tubulovillous adenomas, and 47 cases of sporadic colorectal carcinomas arising on the basis of preexisting adenomas, using immunohistochemistry.
  • Carcinomas arising from VEGF-positive adenomas were mostly VEGF positive (10/11, 91%), whereas in 28/36 (78%) carcinomas arising from VEGF-negative adenomas VEGF expression was not detected.
  • We conclude that VEGF associates with angiogenesis in colorectal cancer, and its pattern of expression in adenomas is maintained in the arising carcinomas.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Colorectal Neoplasms / metabolism. Gene Expression. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 16555551.001).
  • [ISSN] 0965-0407
  • [Journal-full-title] Oncology research
  • [ISO-abbreviation] Oncol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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46. Ma KW, Chia NH, Yeung HW, Cheung MT: If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies. Hong Kong Med J; 2010 Feb;16(1):12-7
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  • Female patients of reproductive age (11-50 years) conferred an independent risk for a higher negative appendectomy rate than other females (28.7% vs 11.5%; P<0.001).
  • Multivariate analysis suggested that a preoperative white cell count of less than 13.5 x 10(9) /L was an independent predictor of negative appendectomy (P<0.001); the body temperature and pulse rate of the patients with perforated appendicitis were higher than in those without perforation (P=0.004 and 0.003, respectively).
  • In this series there were eight carcinoid tumours, three adenocarcinomas, two mucinous cystadenomas; tubular adenoma, metastatic deposition, mucinous cystadenocarcinoma and pseudomyxoma peritonei each occurred in one patient only.
  • Long-term follow-up should be offered to patients with granulomatous appendicitis and neoplastic appendiceal diseases.

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  • [CommentIn] Hong Kong Med J. 2010 Apr;16(2):158 [20354257.001]
  • (PMID = 20124568.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 27
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47. Pisano C, Ottaiano A, Tatangelo F, Di Bonito M, Falanga M, Iaffaioli VR, Botti G, Pignata S, Acquaviva AM: Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas. Anticancer Res; 2005 May-Jun;25(3B):2065-8
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  • [Title] Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas.
  • MATERIALS AND METHODS: The expression of COX-2 was evaluated in 68 paraffin-embedded sporadic colorectal adenomas by immunohistochemistry.
  • Associations between COX-2 expression and the clinicopathological characteristics of the adenomas were studied by contingency tables and the Chi-square test.
  • RESULTS: Cytoplasmic staining for COX-2 protein was present in epithelial cells of 62 out of the 68 adenomas.
  • Furthermore, no significant correlations were found between the expression of the protein and histology (tubular vs tubulovillous), localization (proximal vs distal) or morphology (sessil vs pedunculated) of the adenomas.
  • Both stromal and epithelial COX-2 expressions were higher in larger (>4 mm) compared with smaller (< or =4 mm) adenomas (p =0.
  • CONCLUSION: These data support the hypothesis that the expression of COX-2 may occur as a general phenomenon in colorectal adenomas.
  • [MeSH-major] Adenoma / enzymology. Adenoma / pathology. Colorectal Neoplasms / enzymology. Colorectal Neoplasms / pathology. Prostaglandin-Endoperoxide Synthases / biosynthesis

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  • (PMID = 16158946.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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48. Trawiński J, Patera J, Stanek-Widera A, Koktysz R, Kozłowski W: [Pathomorphologic diagnostic guidelines for colon polyps]. Pol Merkur Lekarski; 2007 May;22(131):454-6
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  • Among polypoid laesions of the large bowel the great attention should be payed to Adenomas because of they neoplastic transformation capabilities.
  • In this paper a classification of neoplastic adenomas extended with serrated adenoma and hyperplastic polyps with presence of tubular adenoma structures has been presented.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Colonic Polyps / pathology

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  • (PMID = 17679394.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 20
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49. Nonogaki K, Hirooka Y, Itoh A, Kawashima H, Hara K, Uchida H, Kasugai T, Ohno E, Ohmiya N, Niwa Y, Goto H: [A case of gallbladder adenoma with wide base]. Nihon Shokakibyo Gakkai Zasshi; 2008 Jan;105(1):74-80
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  • [Title] [A case of gallbladder adenoma with wide base].
  • A 65-year-old man was referred for a gallbladder elevated lesion.
  • Cholecystectomy was performed and the tumor was diagnosed as tubular adenoma of the gallbladder.
  • A gallbladder adenoma with wide base is rare, here we report this case with the several considerations.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 18176045.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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50. Vanderhyden BC: Loss of ovarian function and the risk of ovarian cancer. Cell Tissue Res; 2005 Oct;322(1):117-24
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  • Animal models with premature ovarian failure resulting from the loss or depletion of germ cells consistently develop ovarian surface epithelial cell hyperplasia with invasion into the stroma and the development of ovarian tubular adenomas.

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  • (PMID = 15902502.001).
  • [ISSN] 0302-766X
  • [Journal-full-title] Cell and tissue research
  • [ISO-abbreviation] Cell Tissue Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Gonadotropins; 4G7DS2Q64Y / Progesterone
  • [Number-of-references] 70
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51. Kurobe M, Abe K, Kinoshita N, Anami M, Tokai H, Ryu Y, Wen CY, Kanematsu T, Hayashi T: Hyperplastic polyposis associated with two asynchronous colon cancers. World J Gastroenterol; 2007 Jun 21;13(23):3255-8
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  • We report a patient with hyperplastic polyposis who had two asynchronous colon cancers, a combined adenoma-hyperplastic polyp, a serrated adenoma, and tubular adenomas.
  • Hyperplastic polyposis is thought to be a precancerous lesion; and adenocarcinoma arises from hyperplastic polyposis through the hyperplastic polyp-adenoma-carcinoma sequence.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Colonic Neoplasms / pathology. Intestinal Polyps / pathology. Precancerous Conditions / pathology

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  • (PMID = 17589908.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436615
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52. Gatto A, Falvo L, Sebastiani S, Roncolini G, Pinna G: Triple synchronous tumours of the urinary system with different histologies: a case report. Chir Ital; 2009 May-Jun;61(3):381-5
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  • We present the case report of a male patient with a diagnosis of synchronous kidney, bladder and prostate tumours with different histologies: renal oncocytoma, urothelial carcinoma of the bladder, and adenocarcinoma of the prostate.
  • One such marker recently identified is the prostate-specific membrane antigen (PSMA), present with high expression in carcinoma of the prostate and in the vascular endothelium of solid tumours; only overexpression of PSMA is to be regarded as diagnostic, inasmuch as this antigen is normally expressed in the renal tubular epithelium.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenoma, Oxyphilic / pathology. Aged. Carcinoma / pathology. Humans. Male. Risk Factors. Smoking / adverse effects. Treatment Outcome


53. Esendagli G, Yilmaz G, Canpinar H, Gunel-Ozcan A, Guc MO, Guc D: Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats. Lab Anim; 2009 Jan;43(1):60-4
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  • These tumours were diagnosed as fibroadenoma, combined tubular adenoma and fibroadenoma, hyperkeratotic papilloma, keratinous cyst and malignant peripheral nerve sheath tumour (MPNST) with smooth muscle differentiation.

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  • (PMID = 18987061.001).
  • [ISSN] 0023-6772
  • [Journal-full-title] Laboratory animals
  • [ISO-abbreviation] Lab. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 684-93-5 / Methylnitrosourea
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54. Collins JF, Lieberman DA, Durbin TE, Weiss DG, Veterans Affairs Cooperative Study #380 Group: Accuracy of screening for fecal occult blood on a single stool sample obtained by digital rectal examination: a comparison with recommended sampling practice. Ann Intern Med; 2005 Jan 18;142(2):81-5
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  • The effectiveness of a single digital FOBT is unknown.
  • We calculated predictive values and likelihood ratios for advanced neoplasia, defined as tubular adenomas 10 mm or greater, adenomas with villous histology or high-grade dysplasia, or invasive cancer.
  • When digital FOBT is performed as part of a primary care physical examination, negative results do not decrease the odds of advanced neoplasia.

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  • [CommentIn] Ann Intern Med. 2005 Aug 2;143(3):235 [16061928.001]
  • [CommentIn] Ann Intern Med. 2005 Aug 2;143(3):235; author reply 236 [16061927.001]
  • [CommentIn] Ann Intern Med. 2005 Aug 2;143(3):235-6; author reply 236 [16061925.001]
  • [CommentIn] Gastroenterology. 2005 Jul;129(1):384-6 [16705773.001]
  • [CommentIn] Ann Intern Med. 2005 Jan 18;142(2):146-8 [15657163.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2005 Jan 18;142(2):I23 [15657150.001]
  • (PMID = 15657155.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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55. Muthukrishnan J, Jha S, Modi KD, Jha R, Kumar J, Verma A, Harikumar KV, Patro K, Srinivas B, Kumaresan K, Ramasubba R: Symptomatic primary hyperparathyroidism: a retrospective analysis of fifty one cases from a single centre. J Assoc Physicians India; 2008 Jul;56:503-7
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  • Distal Renal tubular acidosis was diagnosed in 4 cases, 3 of whom normalized after surgery.
  • Ectopic parathyroid adenoma was seen in 7 cases (3 mediastinal, 3 intrathyroidal, 1 near left carotid sheath).
  • [MeSH-major] Acidosis, Renal Tubular. Hyperparathyroidism, Primary / epidemiology. Vitamin D Deficiency / epidemiology

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  • (PMID = 18846900.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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56. Gil Martínez EM, Ramírez López MA, Moya García F, González Cabezas P, de la Riva Pérez P: [Early detection with FDG-PET of colonic tumors in patients with another known tumor]. Gastroenterol Hepatol; 2005 Jan;28(1):23-5
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  • [Transliterated title] Detección temprana con PET-FDG de tumores inesperados de colon en pacientes con otra patología tumoral conocida.
  • Endoscopic polypectomy and pathologic analysis were performed, revealing 2 colon cancers and a tubular adenoma with a high degree of focal atypia.
  • [MeSH-minor] Adenocarcinoma / radionuclide imaging. Adenoma / radionuclide imaging. Aged. Early Diagnosis. Humans. Lung Neoplasms / radionuclide imaging. Male. Melanoma / radionuclide imaging. Middle Aged. Skin Neoplasms / radionuclide imaging

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  • (PMID = 15691465.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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57. Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R: Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology; 2009;41(4):372-8
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  • [Title] Mammary-like gland adenoma of the vulva: review of 46 cases.
  • AIMS: Hidradenoma papilliferum (HP) of the anogenital region, which was previously thought to be an apocrine tumour, is now believed to be derived from anogenital mammary-like glands (MLG) and is more accurately termed MLG adenoma.
  • Tubular, papillary, cystic and solid areas were seen in various combinations.
  • Two cell types, epithelial and myoepithelial, were present.
  • The most common epithelial cell, the ductal cell, was seen alone in 43% or associated with apocrine metaplasia (57%) and/or foam cells (13%) and/or squamous cells (13%).
  • Myoepithelial cells were usually flattened, but were prominent and clear cell in type in 11%.
  • Unusual architectural patterns resembled breast lesions such as erosive adenomatosis, sclerosing adenosis and ductal adenoma.
  • CONCLUSIONS: MLG adenomas demonstrate a marked diversity in histological pattern and cell morphology.
  • The ductal cell and a site compatible with and/or the presence of adjacent normal MLG are the most characteristic features.
  • Unusual vulvar tumours, which have been previously reported as erosive adenomatosis, sclerosing adenosis, papillary adenofibroma, syringocystadenoma papilliferans, etc., are variants of MLG adenomas.
  • [MeSH-major] Adenoma / pathology. Mammary Glands, Human / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19404851.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 46
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58. Riaz N, Khan SM, Idrees R, Kayani N: Infiltrating syringomatous adenoma of nipple. J Coll Physicians Surg Pak; 2008 Jul;18(7):438-9
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  • [Title] Infiltrating syringomatous adenoma of nipple.
  • Infiltrating syringomatous adenoma of the nipple is a rare, benign lesion with distinct clinical and histological features.
  • Important differential diagnosis include nipple adenoma, tubular carcinoma and adenosquamous carcinoma.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Nipples

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  • (PMID = 18760070.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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59. Sieg A, Theilmeier A: [Results of coloscopy screening in 2005--an Internet-based documentation]. Dtsch Med Wochenschr; 2006 Feb 24;131(8):379-83
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  • Advanced adenoma was defined as an adenoma >10 mm in diameter, with villous or tubulovillous histology, or presence of high-grade dysplasia.
  • Tubular and villous adenomas were found in 16.2% and 3.8%, respectively, whereas invasive cancers were diagnosed in 0.7%.
  • Advanced adenomas amounted to 6.1%.The majority of carcinomas were detected in early stages (UICC stages I and II in 48 and 22 %, respectively).
  • [MeSH-major] Adenoma / epidemiology. Adenoma, Villous / epidemiology. Carcinoma / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / epidemiology. Internet. Mass Screening. Registries

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  • (PMID = 16479468.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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60. Saad A, Rex DK: Routine rectal retroflexion during colonoscopy has a low yield for neoplasia. World J Gastroenterol; 2008 Nov 14;14(42):6503-5
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  • Seven polyps were visualized only by retroflexion (6 hyperplastic sessile polyps, one 4 mm sessile tubular adenoma).

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  • [Cites] Gastroenterology. 2007 Jul;133(1):42-7 [17631129.001]
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  • (PMID = 19030202.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2773336
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61. Hetzel JT, Huang CS, Coukos JA, Omstead K, Cerda SR, Yang S, O'Brien MJ, Farraye FA: Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol; 2010 Dec;105(12):2656-64
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  • Polyps were classified as adenoma (tubular, tubulovillous, or villous), serrated polyp (hyperplastic polyp (HP), sessile serrated adenoma (SSA), or dysplastic serrated polyp (DSP)), adenocarcinoma, or other.
  • Detection prevalence (patients with at least one polyp per 100 colonoscopies) was 22.2 for adenomas, 11.7 for HP, 0.6 for SSA, and 0.2 for DSP.
  • Detection prevalences among endoscopists differed significantly for adenomas, HP, and SSA.
  • Classification rates among pathologists differed significantly for HP and SSA, but not for adenoma or DSP.
  • On multivariate analysis, endoscopist was a significant predictor of adenoma, HP, and SSA.
  • Pathologist was a significant predictor of HP, SSA, and DSP, but not adenoma.
  • Detection of adenoma, HP, and SSA differed significantly by endoscopist.
  • Classification of HP and SSA differed significantly by pathologist.
  • Endoscopy and pathology practices should consider educational interventions to improve serrated polyp detection and standardize classification.


62. Otake S, Takeda H, Suzuki Y, Fukui T, Watanabe S, Ishihama K, Saito T, Togashi H, Nakamura T, Matsuzawa Y, Kawata S: Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res; 2005 May 15;11(10):3642-6
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  • [Title] Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance.
  • To investigate whether visceral fat accumulation contributes to colorectal carcinogenesis, we examined its accumulation and the levels of the adipose tissue-derived hormone adiponectin in Japanese patients with colorectal adenoma.
  • EXPERIMENTAL DESIGN: Fifty-one consecutive Japanese patients ages >/=40 years and with colorectal adenoma were subjected to measurement of visceral fat area by computed tomography scanning and plasma adiponectin concentration.
  • RESULTS: The patients with colorectal adenoma showed significantly more visceral fat area and significantly less plasma adiponectin concentration in comparison with the controls [odds ratio (OR), 2.19; 95% confidence interval (95% CI), 1.47-3.28; P < 0.001 and OR, 0.24; 95% CI, 0.14-0.41; P < 0.001, respectively] by logistic regression analysis.
  • HOMA-IR index was also associated with colorectal adenoma (OR 2.60; 95% CI, 1.20-5.64; P = 0.040).
  • Visceral fat area and adiponectin were associated with adenoma number (1, 2, >/= 3), the size of the largest adenoma (<10 and >/=10 mm), and adenoma histology (tubular and tubulovillous/villous).
  • CONCLUSIONS: These results suggest an association of visceral fat accumulation and decreased plasma adiponectin concentration with colorectal adenoma in Japanese patients.
  • [MeSH-major] Adenoma / physiopathology. Adipose Tissue. Body Composition. Colorectal Neoplasms / physiopathology. Insulin Resistance. Intercellular Signaling Peptides and Proteins / blood

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  • (PMID = 15897559.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Intercellular Signaling Peptides and Proteins
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63. Sanada Y, Kunita S, Yoshida K: Comparison of histologic subtype and growth pattern in intraductal papillary-mucinous carcinoma of the pancreas. Oncol Rep; 2008 Jun;19(6):1435-43
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  • [Title] Comparison of histologic subtype and growth pattern in intraductal papillary-mucinous carcinoma of the pancreas.
  • The purpose of this study was to compare histologic subtype and growth pattern, including invasion and intraductal spread to branch ducts, in main duct-type intraductal papillary-mucinous carcinoma (IPMC) by histopathology and immunohistochemistry.
  • Three cases showed adenoma components in the main duct.
  • The other case showed gastric-type adenoma and intestinal-type carcinoma in situ (CIS) in the main duct, with minimal tubular invasion.
  • The two remaining cases showed no adenoma components in the main duct, but showed abrupt transition from normal epithelium to CIS (pancreatobiliary type or oncocytic type) and massive invasion diffusely positive for OPRT.
  • These results suggest that IPMC with adenoma components in the main duct undergoes intraductal spread to branch ducts and has low malignant potential.
  • The progression of one subtype to another is associated with intraductal spread of intraductal papillary-mucinous neoplasm (IPMN).
  • However, IPMC without adenoma components is associated with marked invasion.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Cell Transformation, Neoplastic / pathology. Intestinal Neoplasms / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18497948.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / Mucins; EC 2.4.2.10 / Orotate Phosphoribosyltransferase
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64. Kos M, Nogales FF, Kos M, Stipoljev F, Kunjko K: Congenital juvenile granulosa cell tumor of the testis in a fetus showing full 69,XXY triploidy. Int J Surg Pathol; 2005 Apr;13(2):219-21
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  • [Title] Congenital juvenile granulosa cell tumor of the testis in a fetus showing full 69,XXY triploidy.
  • Testicular juvenile granulosa cell tumor (TJGCT) occurs predominantly in infancy and may be associated with sex chromosomal abnormalities.
  • It was connected with a tubular uterus-like structure.
  • The other gonad was an inguinally localized testis that showed histologically a Sertoli cell adenoma.
  • [MeSH-major] Disorders of Sex Development / pathology. Fetus / abnormalities. Granulosa Cell Tumor / pathology. Polyploidy. Testicular Neoplasms / pathology

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  • (PMID = 15864389.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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65. Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO: Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem; 2005 Feb 04;280(5):3938-45
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  • [Title] Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.
  • Analysis of these adults revealed severely cystic kidneys associated with the presence of renal adenomas.
  • [MeSH-major] Adenoma / physiopathology. Genes, APC / physiology. Kidney Neoplasms / physiopathology. Polycystic Kidney Diseases / physiopathology

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  • (PMID = 15550389.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P50 DK057328; United States / NIDDK NIH HHS / DK / R01 DK067565; United States / NIDDK NIH HHS / DK / DK-42921; United States / NIDDK NIH HHS / DK / DK-57328; United States / NIDDK NIH HHS / DK / R01 DK042921; United States / NIDDK NIH HHS / DK / DK-67565
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, mouse; 0 / Cytoskeletal Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Trans-Activators; 0 / Wnt Proteins; 0 / beta Catenin; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases
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66. Arditi C, Gonvers JJ, Burnand B, Minoli G, Oertli D, Lacaine F, Dubois RW, Vader JP, Schusselé Filliettaz S, Peytremann-Bridevaux I, Pittet V, Juillerat P, Froehlich F, EPAGE II Study Group: Appropriateness of colonoscopy in Europe (EPAGE II). Surveillance after polypectomy and after resection of colorectal cancer. Endoscopy; 2009 Mar;41(3):209-17
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  • The characteristics of removed polyps, especially the distinction between low-risk adenomas (1 or 2, small [< 1 cm], tubular, no high-grade dysplasia) vs. high-risk adenomas (large [> or = 1 cm], multiple [> 3], high-grade dysplasia or villous features), have an impact on advanced adenoma recurrence.
  • Most guidelines recommend a 3-year follow-up colonoscopy for high-risk adenomas and a 5-year colonoscopy for low-risk adenomas.

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  • (PMID = 19280532.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 115
  • [Investigator] Agréus L; Beglinger C; Bytzer P; Delvaux M; Eckardt V; Fairclough P; Lacaine F; Le Moine O; Lorenzo-Zúñiga V; Minoli G; Numans M; Oertli D; O'Malley J; Windsor A
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67. Choi JS, Kim MK, Seo JW, Choi YL, Kim DH, Chun YK, Ko YH: MET expression in sporadic renal cell carcinomas. J Korean Med Sci; 2006 Aug;21(4):672-7
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  • [Title] MET expression in sporadic renal cell carcinomas.
  • Although germline mutations of met proto-oncogene on human chromosome 7q31-34 have been known as useful molecular markers of hereditary papillary renal cell carcinoma (RCC), the expression of MET, a product of met proto-oncogene, has not been fully studied in sporadic RCC, along with its clinical significance.
  • On the contrary, clear cell RCC, chromophobe RCC, and oncocytomas were negative or focally positive for MET expression.
  • In clear cell RCC, MET expression was positively correlated with high nuclear grade, presence of infiltrative growth, tumoral necrosis, papillary architecture, sarcomatoid component, tumoral involvement of the renal pelvis or ureter, involvement of the calyx, and lymphatic invasion.
  • In conclusion, diffuse and strong expression of MET in papillary RCC and collecting duct carcinoma might be helpful in discriminating from the other subtypes of RCC with tubular or papillary growth.
  • In case of MET expression observed in clear cell RCC, it might correlate with those clinicopathological parameters implying aggressive behavior.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Proto-Oncogene Proteins / biosynthesis. Receptors, Growth Factor / biosynthesis
  • [MeSH-minor] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Humans. Immunohistochemistry. Kidney Pelvis / chemistry. Kidney Pelvis / pathology. Neoplasm Staging. Proto-Oncogene Proteins c-met. Urothelium / chemistry. Urothelium / pathology

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  • (PMID = 16891811.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins; 0 / Receptors, Growth Factor; EC 2.7.10.1 / MET protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
  • [Other-IDs] NLM/ PMC2729889
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68. Babich JP, Klein J, Friedel DM: Endoscopic removal of a brunneroma with EUS guidance. South Med J; 2010 Mar;103(3):250-2
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  • [Title] Endoscopic removal of a brunneroma with EUS guidance.
  • Brunner glands are compound tubular submucosal glands typically found in the duodenal bulb.
  • The most common benign tumors of the small intestine are adenoma, and 25% of these occur in the duodenum.
  • Among the benign tumors of the duodenum, 30-50% arise from the Brunner glands.
  • Most of the literature describes their presentations as ranging from benign, nonspecific, epigastric discomfort to obstruction and intestinal bleeding.
  • We present one of the first cases of an endoscopic ultrasound (EUS) approach to the diagnosis and therapeutic removal of a brunneroma.
  • [MeSH-major] Adenoma / surgery. Brunner Glands / surgery. Duodenal Neoplasms / surgery. Duodenoscopy / methods

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  • (PMID = 20134393.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Saglam O, Garrett CR, Boulware D, Sayegh Z, Shibata D, Malafa M, Yeatman T, Cheng JQ, Sebti S, Coppola D: Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia. Clin Colorectal Cancer; 2007 Sep;6(9):652-6
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  • BACKGROUND: AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis.
  • MATERIALS AND METHODS: We used stage-oriented human CRC tissue microarrays, including 99 invasive carcinomas, 28 tubular adenomas, and 18 samples of normal colonic mucosa.
  • Eighty-two percent of adenomas were weakly positive for p-AKT, 1 was p-AKT negative, and none exhibited strong or moderate p-AKT stain.
  • At a significance level of .05, we found that the distribution of p-AKT stain scores for cancer was shifted to the right of adenoma (P < .0001) and normal (P < .0001) and for adenoma was shifted to the right of normal (P < .0001).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Proto-Oncogene Proteins c-akt / biosynthesis

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  • (PMID = 17945038.001).
  • [ISSN] 1533-0028
  • [Journal-full-title] Clinical colorectal cancer
  • [ISO-abbreviation] Clin Colorectal Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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70. Ghidirim G, Mişin I, Istrate V, Cazacu S: Endoscopic papillectomy into the treatment of neoplastic lesions of vater papilla. Curr Health Sci J; 2009 Apr;35(2):92-7
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  • Adenomas of the duodenal papilla are rare.
  • The frequency of malignant adenomas is 15-30%.
  • Villous adenoma is a premalignant lesion with the highest rate of transformation.
  • AIM: Evaluation of the efficacy and safety of endoscopic papillectomy for ampullary adenomas.
  • MATERIAL AND METHOD: 12 patients were selected (F:M, 5:7, age range 37 - 68 years) with ampullary adenoma, treated by endoscopic papillectomy.
  • RESULTS: En bloc resection was performed in 8 cases, and piecemeal resection in 4 cases.
  • Pathology examination has show: tubulo-villous adenoma (5 patients); villous adenoma (4 patients), tubular adenoma (2 cases), adenocarcinoma (one case).
  • CONCLUSION: Endoscopic papillectomy is a safe and well-tolerated alternative to surgical treatment of ampullary adenoma.

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  • (PMID = 24778815.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945241
  • [Keywords] NOTNLM ; Vater papilla / ampullary adenoma / bleeding / endoscopic papillectomy / pancreatitis / sphyncterotomy
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71. Kim YH, Kakar S, Cun L, Deng G, Kim YS: Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps. Int J Cancer; 2008 Dec 1;123(11):2587-93
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  • Since limited data are available on different histological types of colorectal polyps, we compared the pattern and the frequency of promoter methylation, CIMP-H, MSI, KRAS and BRAF V600E mutations and the relationship among these molecular parameters and the clinicopathologic characteristics in 110 serrated polyps (48 hyperplastic polyps, 32 sessile serrated adenomas and 30 serrated adenomas) and 32 tubular adenomas using 7 commonly used tumor-associated gene loci.
  • No significant difference in the frequency of overall methylation frequency (86% vs. 100%) and CIMP-H (39% vs. 28%) between serrated polyps and tubular adenomas was observed, but proximally located serrated polyps showed more frequent methylation at 5 of 7 loci examined, and were more likely to be CIMP-H (62% vs. 22%).
  • MGMT methylation was more common in tubular adenomas while MLH1 and HIC1 were more frequently methylated in serrated polyps.
  • BRAF mutation was frequently present in all types of serrated polyps (80%), but was absent in tubular adenomas and was not associated with CIMP or MSI status.
  • These results show comparable frequencies of promoter methylation of tumor-associated genes and CIMP-H, but distinct differences in gene-specific or colonic site-specific methylation profiles occur in serrated polyps and tubular adenomas.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18798261.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nerve Tissue Proteins; 0 / RNA-Binding Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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72. Ullah N, Qureshi K, Yordanova V, Hatfield J, Sochacki P, Lawson M, Tobi M: Differential labeling by monoclonal antibodies Adnab-9 and anti-alpha-defensin 5 based on the distribution and adenomatous tissue content of colonic polyps. Dig Dis Sci; 2005 Apr;50(4):708-13
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  • We sought a correlation between site and morphology of colonic polyps by labeling with neoplastic and general Paneth cell markers, monoclonal antibodies Adnab-9 and anti-alpha-defensin 5, respectively.
  • Proportions labeled by Adnab-9 and anti-alpha-defensin 5 were, respectively, 42 and 85% for adenomas, 39 and 63% for early tubular adenomas, 41 and 44% for serrated, 34 and 20% for mixed, and 11 versus 2.7% for hyperplastic polyps.
  • While increased labeling of all proximal polyps compared to distal ones mirrored the colonic distribution of Paneth cells, distal adenomas tended to have a higher proportion labeled by Adnab-9, suggesting that Adnab-9 labels Paneth cells associated with increased neoplastic potential.

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  • (PMID = 15844706.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / alpha-Defensins; 0 / alpha-defensin 5, human
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73. Bukhari MH, Salaria SM, Niaz Z, Muzzafar A, Batool Z, Qureshi GR, Naveed IA, Chaudhry NA: Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice. J Coll Physicians Surg Pak; 2006 Apr;16(4):280-3
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  • [Title] Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice.
  • OBJECTIVE: To determine the mutation of p53 in chemically induced carcinogenesis on albino mice in skin papilloma and tubular adenoma breast by immunohistochemistry.
  • SUBJECTS AND METHODS: Twenty five albino mice (male and female) were selected for a study on chemical carcinogenesis.
  • Squamous cell papillomas and tubular adenoma breast were selected for this study.
  • RESULTS: All the papillomas showed faint reactivity for immunomarker p53, while tubular adenomas were nonreactive.
  • [MeSH-major] Adenoma / genetics. Biomarkers, Tumor / analysis. Breast Neoplasms / genetics. Genes, p53. Mutation. Papilloma / genetics

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  • (PMID = 16624193.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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74. Onishi T, Tamura S, Kuratani Y, Onishi S, Yasuda N: Evaluation of the depth score of type V pit patterns in crypt orifices of colorectal neoplastic lesions. J Gastroenterol; 2008;43(4):291-7
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  • BACKGROUND: We developed and evaluated the clinical usefulness of a scoring system that subclassified type VI: pit patterns.
  • METHODS: We studied 119 colon cancer lesions (pTis, n = 26; pT1, n = 93) and 22 tubular adenoma lesions with severe atypia in which a type VI: pit pattern was visible under a stereomicroscope.
  • RESULTS: When the four type VI: pit pattern appearances were considered in a logistic regression analysis, the odds of a more invasive submucosal cancer were significantly increased by the appearance of marginal irregularities, a narrowed lumen, and an unclear outline.
  • In the logistic regression analysis results, when 0.63 was used as the cutoff score for prediction of a more invasive submucosal cancer, 80 cases in the less invasive group were classified correctly (specificity, 1.0), whereas 53 (86.9%) of the 61 cases in the more invasive group were classified correctly (sensitivity, 0.869).

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  • (PMID = 18458845.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Japan
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75. Kim DH, Kim JW, Cho JH, Baek SH, Kakar S, Kim GE, Sleisenger MH, Kim YS: Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum. Int J Oncol; 2005 Oct;27(4):957-64
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  • Mucin core proteins are expressed in a tissue and cell type specific manner in the normal gastrointestinal tract.
  • To examine the relationship between subsets of colorectal polyps and non-mucinous and mucinous adenocarcinomas of the colorectum, we evaluated the frequency of the expression of cell lineage associated mucin core proteins (MUC5AC and MUC2), trefoil factors (TFF1 and TFF3), and APC and p21 in these tissues.
  • An immunohistochemical study was performed in 10 normal rectal mucosa samples (NM) 21 hyperplastic polyps (HP), 20 serrated adenomas (SA), 25 tubular adenomas (TA), 13 tubulovillous adenomas (TVA), 7 villous adenomas (VA), 42 non-mucinous colorectal cancers (NMC), and 19 mucinous colorectal cancers (MC).
  • A higher frequency of ectopic expression of gastric foveolar mucin, MUC5AC, and the expression of intestinal goblet cell mucins, MUC2, was observed respectively in HP (100%, 100%), SA (85%, 85%), TVA (85%, 85%), and VA (100%, 100%), compared to TA (32%, p<0.002; 36%, p<0.01).
  • Our results showed that MUC2 expression and de novo ectopic expression of MUC5AC and TFF1 are more frequent in HP, SA, TVA, VA, and MC than in TA and NMC.
  • [MeSH-minor] Adenoma / metabolism. Cell Differentiation. Cell Line, Tumor. Cell Lineage. Cell Nucleus / metabolism. Cytoplasm / metabolism. Humans. Immunohistochemistry. Mucin 5AC. Mucin-2

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  • (PMID = 16142311.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucins; 0 / Peptides; 0 / TFF1 protein, human; 0 / TFF3 protein, human; 0 / Tumor Suppressor Proteins; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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76. Farah Klibi F, Ferchichi L, Borgi C, Jemaa Y, Najjar T, Ben Jilani S, Zermani R: [Histopathological study of gastric polyps. A report of 65 cases]. Tunis Med; 2006 Oct;84(10):611-6
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  • [Transliterated title] Etude anatomo-pathologique des polypes gastriques. A propos de 65 cas.
  • All adenomas and two Peutz-Jeghers polyps include intraepithelial neoplasia.
  • Moreover, we identified a case of Brunner's gland heterotopia, which contain a focus of plane tubular adenoma with high-grade intraepithelial neoplasia.
  • [MeSH-major] Adenomatous Polyps / pathology. Carcinoid Tumor / pathology. Cell Transformation, Neoplastic / pathology. Peutz-Jeghers Syndrome / pathology. Polyps / pathology. Stomach / pathology. Stomach Diseases / pathology. Stomach Neoplasms / pathology

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  • (PMID = 17193851.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Tunisia
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77. Sokolova IA, Hes O, Michal M, Matsko DE: [Small-cell variant of renal oncocytoma]. Arkh Patol; 2007 Sep-Oct;69(5):34-6
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  • [Title] [Small-cell variant of renal oncocytoma].
  • Renal oncocytoma is a distinct benign tumor accounting for approximately 3-5% of all renal tumors.
  • The tumor cells are arranged in nests and tubular pattern.
  • The term "small-cell variant of renal oncocytoma" was proposed for these cases.
  • The unusual extensive small-cell component of the tumor may represent a potential diagnostic pitfall for primary or metastatic malignant small cell tumors.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Small Cell / pathology. Cytoplasm / pathology. Kidney Neoplasms / pathology. Mitochondria / pathology

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  • (PMID = 18074818.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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78. Kuwabara H, Haginomori S, Takamaki A, Ito K, Takenaka H, Kurisu Y, Tsuji M, Mori H: Lipomatous pleomorphic adenoma of the ceruminous gland. Pathol Int; 2006 Jan;56(1):51-3
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  • [Title] Lipomatous pleomorphic adenoma of the ceruminous gland.
  • A case of lipomatous pleomorphic adenoma in the ceruminous gland is reported.
  • Light microscopic examination revealed a well-circumscribed tumor composed of tubular structures with apocrine secretion and ceroid deposition, extensive mature adipocytes, and spindle-shaped myoepithelial cells in the myxoid and fibrous stroma.
  • This case demonstrates the peculiar location of a lipomatous pleomorphic adenoma in the external auditory canal.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Ear Canal. Ear Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16398681.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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79. Zhang X, Leav I, Revelo MP, Deka R, Medvedovic M, Jiang Z, Ho SM: Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon. PLoS Genet; 2009 Jan;5(1):e1000334
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  • AMACR was first found overexpressed in prostate cancer but not in benign glands and is now an established diagnostic marker for prostate cancer.
  • By using a panel of immunostained-laser-capture-microdissected clinical samples comprising the entire colon adenoma-carcinoma sequence, we show that deregulation of AMACR during colon carcinogenesis involves two nonrandom events, resulting in the mutually exclusive existence of double-deletion at CG3 and CG10 and deletion of CG12-16 in a newly identified CpG island within the core promoter of AMACR.
  • It existed in histologically normal colonic glands and tubular adenomas with low AMACR expression and was absent in villous adenomas and all CCas expressing variable levels of AMACR.
  • [MeSH-minor] Adenoma, Villous / genetics. Adenoma, Villous / metabolism. Adenoma, Villous / pathology. Base Sequence. Binding Sites. Cell Differentiation. Cell Line, Tumor. Humans. Molecular Sequence Data. Polymorphism, Genetic. Repressor Proteins / metabolism. Sequence Deletion / genetics. Transcription, Genetic

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  • (PMID = 19148275.001).
  • [ISSN] 1553-7404
  • [Journal-full-title] PLoS genetics
  • [ISO-abbreviation] PLoS Genet.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA112532; United States / NCI NIH HHS / CA / R01 CA112532; United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NCI NIH HHS / CA / R01 CA015776; United States / NCI NIH HHS / CA / CA015776; United States / NCI NIH HHS / CA / R01 CA062269; United States / NCI NIH HHS / CA / CA062269
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Repressor Proteins; 0 / ZNF202 protein, human; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
  • [Other-IDs] NLM/ PMC2613032
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80. Molinié V, Balaton A, Rotman S, Mansouri D, De Pinieux I, Homsi T, Guillou L: Alpha-methyl CoA racemase expression in renal cell carcinomas. Hum Pathol; 2006 Jun;37(6):698-703
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  • [Title] Alpha-methyl CoA racemase expression in renal cell carcinomas.
  • Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs).
  • We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type 2); 25 conventional RCCs; 6 chromophobe RCCs; 9 oncocytomas; 5 mucinous tubular and spindle tumors; 2 urothelial carcinomas; 7 angiomyolipomas; and 2 Bellini carcinomas.
  • The 5 mucinous, tubular, and spindle cell carcinomas strongly expressed AMACR, and only 5 of 25 clear cell RCCs and 1 of 9 oncocytomas were focally reactive.
  • Because high expression of AMACR is found in papillary RCCs (type 1 and 2) and in mucinous, tubular, and spindle cell carcinomas of the kidney, immunostaining for AMACR should be used in conjunction with other markers when histological typing of a renal tumor is difficult.
  • [MeSH-major] Carcinoma, Renal Cell / enzymology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / enzymology. Kidney Neoplasms / pathology. Racemases and Epimerases / metabolism
  • [MeSH-minor] Adenocarcinoma, Mucinous / enzymology. Adenocarcinoma, Mucinous / pathology. Adenoma, Oxyphilic / enzymology. Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / enzymology. Carcinoma, Papillary / pathology. Humans. Immunohistochemistry

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  • (PMID = 16733210.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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81. Nusko G, Hahn EG, Mansmann U: Risk of advanced metachronous colorectal adenoma during long-term follow-up. Int J Colorectal Dis; 2008 Nov;23(11):1065-71
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  • [Title] Risk of advanced metachronous colorectal adenoma during long-term follow-up.
  • BACKGROUND: According to the adenoma-carcinoma concept, all colorectal adenomas are to be removed and all patients have to undergo regular surveillance examinations.
  • Statistical analysis using chi (2)-testing of adenoma characteristics found in four subsequent recurrence periods and calculation of the relative risk (RR) for the development of metachronous adenomas of advanced pathology was performed.
  • RESULTS: In comparison with the initial findings, metachronous adenomas are, in general, significantly smaller ones (p < 0.00001), more frequently tubular lesions (p < 0.00001) and bearing less often high-grade dysplasia (p < 0.00001).
  • Adenomas of advanced pathology were significantly less often found during follow-up than at baseline examination (p < 0.0001).
  • These differences are found between the initial and four subsequent generations of metachronous adenomas.
  • Patients with adenomas of advanced pathology at baseline have a significantly higher risk for metachronous adenomas of advanced pathology (RR 1.51; 95%CI 1.04-1.93) at the first recurrence.
  • CONCLUSIONS: Metachronous adenomas show uniform characteristics of being small tubular lesions rarely bearing high-grade dysplasia.
  • [MeSH-major] Adenoma / etiology. Colonic Polyps / surgery. Colorectal Neoplasms / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 18597098.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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82. Tagaya N, Nakagawa A, Ishikawa Y, Oyama T, Kubota K: Experience with ultrasonographically guided vacuum-assisted resection of benign breast tumors. Clin Radiol; 2008 Apr;63(4):396-400
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  • [Title] Experience with ultrasonographically guided vacuum-assisted resection of benign breast tumors.
  • AIM: To evaluate the feasibility and safety of vacuum-assisted resection of benign breast tumours using an 8 G handheld device.
  • MATERIALS AND METHODS: Over a 2-year period, 22 patients with 26 breast tumours diagnosed as benign using aspiration biopsy cytology were enrolled.
  • The pathological diagnoses were fibroadenoma in 16 cases, mastopathy in six, and tubular adenoma and pseudoangiomatous stromal hyperplasia in two cases each, respectively.

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  • (PMID = 18325359.001).
  • [ISSN] 0009-9260
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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83. Wang SA, Fadare O, Nagar A, Shafi NQ, Rose MG: Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values. Am J Hematol; 2006 May;81(5):324-7
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  • Lower gastrointestinal findings, including large tubular adenomas and arteriovenous malformation, were identified in 3/53 cases (6.7%).
  • [MeSH-major] Anemia, Iron-Deficiency / blood. Endoscopy, Gastrointestinal. Ferritins / blood. Gastrointestinal Diseases

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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16628728.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-73-2 / Ferritins
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84. Dubb M, Michelow P: Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol; 2009 Mar-Apr;53(2):179-82
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  • OBJECTIVE: To review the cytologic features of hidradenoma to describe criteria that may aid in identification of these tumors at the time of aspiration and allow for a more specific diagnosis than the umbrella term of benign skin adnexal tumor.
  • Fine needle aspiration (FNA) of these lesions showed the presence of benign skin adnexal tumors.
  • RESULTS: The following cytomorphologic findings are consistent with the diagnosis of hidradenoma: a cystic component to the aspirate as represented by amorphous background material with or without foam cells and epithelial duct-like cells and tubular structures.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19365971.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Fromont G, Barcat L, Gaudin J, Irani J: Revisiting the immunophenotype of nephrogenic adenoma. Am J Surg Pathol; 2009 Nov;33(11):1654-8
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  • [Title] Revisiting the immunophenotype of nephrogenic adenoma.
  • Nephrogenic adenoma (NA) is a rare benign lesion of the urinary tract.
  • Although its histogenesis is still debated, several reports suggest that the lesion has a renal tubular cell origin or differentiation.
  • Because all the previous studies have used an avidin-biotin (AB) detection procedure, and because cells with tubular renal differentiation are likely to contain a high level of endogenous biotin, we investigated in NA the expression of several markers including AMACR, using both AB and biotin-free detection systems.
  • [MeSH-major] Adenoma / immunology. Immunophenotyping / methods. Urologic Neoplasms / immunology

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  • (PMID = 19730362.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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86. Kono S, Kurosumi M, Simooka H, Kawanowa K, Takei H, Suemasu K: Nipple adenoma found in a mastectomy specimen: report of a case with special regard to the proliferation pattern. Breast Cancer; 2007;14(2):234-8
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  • [Title] Nipple adenoma found in a mastectomy specimen: report of a case with special regard to the proliferation pattern.
  • We report a case of nipple adenoma incidentally found in a mastectomy specimen, and describe its unique histological appearance and the immunohistochemical distribution of Ki-67 positive tumor cells.
  • A small nipple adenoma, 7 mm in size, was incidentally recognized in the nipple of the resected breast.
  • Histologically, the tumor in the nipple was composed of numerous proliferative ducts with a tubular and florid papillomatous appearance.
  • Based on these proliferative patterns, the symptoms and clinical signs related to the nipple that are often found in patients with nipple adenoma are thought to be associated with the destruction of the epidermis of the nipple by the invasion of benign tumor cells with high proliferative activity.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Mastectomy. Nipples / pathology
  • [MeSH-minor] Cell Proliferation. Female. Humans. Immunohistochemistry. Incidental Findings. Ki-67 Antigen / metabolism. Middle Aged

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  • (PMID = 17485911.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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87. Kiziltaş S, Sezgin Ramadan S, Topuzoğlu A, Küllü S: Does the severity of tissue eosinophilia of colonic neoplasms reflect their malignancy potential? Turk J Gastroenterol; 2008 Dec;19(4):239-44
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  • This retrospective study aimed to investigate the frequency and intensity of tissue eosinophilia in various colonic neoplasms, including serrated adenomas.
  • METHODS: We evaluated 448 colonic neoplasms to determine eosinophilic infiltration: 96 hyperplastic polyps, 50 serrated adenomas, 19 flat adenomas, 154 tubular adenomas, 71 tubulovillous adenomas, 13 villous adenomas and 45 adenocarcinomas.
  • RESULTS: Moderate (46.7%) and marked (52.9%) intensity were noted in all colonic adenomas.
  • Mostly moderate eosinophilic infiltration was observed in serrated adenomas.
  • CONCLUSIONS: Our findings suggest that the intensity of tissue eosinophilia is most prominent in adenomas including serrated adenomas and is diminished from adenoma to carcinoma.

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  • (PMID = 19119482.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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88. Minhajat R, Mori D, Yamasaki F, Sugita Y, Satoh T, Tokunaga O: Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers. Virchows Arch; 2006 Feb;448(2):127-34
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  • We immunohistochemically analyzed the expression of the colon adenoma-carcinoma sequence by endothelial cells using a panel of eight endothelial markers.
  • We examined sections from endoscopic mucosal resection and surgical resection of tubular adenoma (n=31), carcinoma in adenoma (n=11), and adenocarcinoma (n=34).
  • CD31 (PECAM-1) was universally expressed in the blood vessels of adenoma-carcinoma lesions as well as in normal mucosal vessels (80-95%), with no significant differences.
  • In normal mucosa, CD105 was weakly expressed in endothelial cells of capillaries (< or =21%), and significant differences in its expression in endothelial cells between the normal mucosa and adenoma, carcinoma in adenoma, and adenocarcinoma were found.
  • Vascular endothelial growth factor was expressed at <30% in the blood vessels of adenoma, carcinoma in adenoma, and carcinoma.
  • The present study shows that de novo blood vessels of colon cancer specifically express CD105.
  • [MeSH-major] Antigens, CD / biosynthesis. Colonic Neoplasms / pathology. Neovascularization, Pathologic / pathology. Receptors, Cell Surface / biosynthesis

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  • (PMID = 16177881.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / ENG protein, human; 0 / Endoglin; 0 / Receptors, Cell Surface
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89. Kinney TP, Merel N, Hart J, Joseph L, Waxman I: Microsatellite analysis of sporadic flat and depressed lesions of the colon. Dig Dis Sci; 2005 Feb;50(2):327-30
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  • Of these specimens, eight were tubular adenomas, three were tubulovillous adenomas, and five were carcinomas in situ.
  • [MeSH-major] Adenoma, Villous / genetics. Colonic Neoplasms / genetics. Microsatellite Repeats

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  • (PMID = 15745095.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Esaki M, Matsumoto T, Yao S, Nakamura S, Hirahashi M, Yao T, Iida M: Immunohistochemical characteristics of duodenal adenomas in familial adenomatous polyposis with special reference to cell kinetics. Hum Pathol; 2005 Jan;36(1):66-73
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  • [Title] Immunohistochemical characteristics of duodenal adenomas in familial adenomatous polyposis with special reference to cell kinetics.
  • The main objective of this study was to evaluate the cell kinetics in duodenal and ampullary adenomas in FAP.
  • The endoscopic and biopsy findings of duodenal adenomas in 22 FAP subjects and 18 non-FAP subjects were compared.
  • Adenomas in FAP included 15 ampullary adenomas and 17 nonampullary adenomas.
  • The cell kinetics was evaluated by immunohistochemistry for Ki-67, p53, bcl-2, and cyclooxygenase 2 (COX2), and the apoptotic index (AI) as determined by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) method.
  • Any correlations between the indices for cell kinetics and the endoscopic findings were identified.
  • All 50 adenomas were histologically verified to be tubular adenoma with low-grade dysplasia.
  • In patients with FAP, duodenal adenoma tended to have a higher Ki-67-labeling index than the ampullary adenoma (54.3 +/- 11.3 versus 46.8 +/- 12.7; .05 < P < .1).
  • In addition, the Ki-67-labeling index in endoscopically normal or slightly enlarged ampullary adenoma was significantly higher than that in markedly enlarged ampullary adenoma (51.8 +/- 11.4 versus 39.4 +/- 11.3; P < .05).
  • Duodenal adenoma in FAP subjects was not found to have a higher proliferative activity or a smaller degree of apoptosis compared with those in non-FAP subjects.
  • The smaller proliferative activity in larger ampullary adenoma may thus be related to the static nature of ampullary adenoma in FAP.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Adenomatous Polyposis Coli / complications. Apoptosis / physiology. Duodenal Neoplasms / metabolism. Duodenal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Cell Proliferation. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology. Cyclooxygenase 2. Female. Genes, APC. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Ki-67 Antigen / metabolism. Male. Membrane Proteins. Middle Aged. Mutation. Polymorphism, Single-Stranded Conformational. Prostaglandin-Endoperoxide Synthases / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 15712184.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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91. Nakata K, Nagai E, Ohuchida K, Aishima S, Hayashi A, Miyasaka Y, Yu J, Mizumoto K, Tanaka M, Tsuneyoshi M: REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms. Mod Pathol; 2009 Mar;22(3):460-8
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  • Regenerating islet-derived family, member 4 (REG4) is associated with the adenoma-carcinoma sequence in colon cancer and it is also associated with intestinal phenotype.
  • The positive ratio of REG4 expression in colloid carcinoma (5/7) was significantly higher than that in tubular carcinoma (1/17; P=0.003).
  • REG4 expression was observed more frequently in borderline lesions (14/28) and carcinoma (21/45) compared to adenoma (8/52).

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  • (PMID = 19136934.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Lectins, C-Type; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / REG4 protein, human; 0 / RNA, Messenger
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92. Bansal A, Liu X, McGregor DH, Singh V, Hall S: Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series. Am J Med Sci; 2010 Oct;340(4):296-300
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  • [Title] Correlation of epidermal growth factor receptor with morphological features of colorectal advanced adenomas: a pilot correlative case series.
  • Although EGFR is described to be overexpressed in adenomas, to the authors' knowledge, its relationship with advanced features in adenomas and as a marker for adenoma progression has not been studied.
  • Subsequently, a validation group of 95 adenomas from 16 patients were graded semiquantitatively for EGFR staining.
  • Size and villous features of the adenomas were evaluated by 2 independent pathologists and compared with EGFR expression.
  • To be classified as advanced, adenomas needed to be greater than 1 cm and fulfill 1 of the 2 criteria-villous component >20% to 25% or presence of high-grade dysplasia.
  • RESULTS: In the index case, the large 5.5 cm tubulovillous adenoma had EGFR positivity in all of its neoplastic cells, whereas another 2 cm tubular adenoma with focal villous features had 30% EGFR positivity.
  • In 95 adenomas from 16 additional patients, there was a significant correlation of EGFR positivity with adenoma size ≥1 cm and villous features (all P < 0.001).
  • The odds of EGFR expression in advanced adenomas were 17.3 times higher than nonadvanced adenomas (P < 0.001).
  • CONCLUSIONS: These findings suggest that EGFR overexpression is associated with advanced colorectal adenomas.
  • Further larger studies are needed to explore EGFR expression as a biomarker for adenoma progression.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Receptor, Epidermal Growth Factor / metabolism

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  • (PMID = 20622650.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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93. Hatanaka K, Tanimoto A, Umekita Y, Yoshioka T, Kanekura T: Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report. Diagn Pathol; 2010;5:42
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  • [Title] Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case report.
  • A dermal cystic lesion developed in the region between the anus and scrotum of a 74-year-old Japanese male.
  • A mural nodule, measuring 1 x 1.5 cm in size, protruded into the cystic space and consisted of a solid proliferation of tubular glands with prominent apocrine secretion and basal myoepithelial cells.
  • Although no mammary-like glands were present in the dermis around the tumor, this unusual apocrine tumor has been suggested to be derived from male anogenital mammary-like glands and mimic a mammary-like gland adenoma in the male perineum.
  • [MeSH-major] Adenoma / pathology. Genital Neoplasms, Male / pathology. Mammary Glands, Human / pathology. Perineum / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 20576161.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2907321
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94. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Title] Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • CASE: A 60-year-old woman, diagnosed with rectal adenocarcinoma 6 months before, underwent fine needle aspiration (FNA) of a nodule on the scalp.
  • (2) cohesive cell clusters and tissue fragments;.
  • (3) tubular formations;.
  • (6) cell sheets with anaplasia and squamous differentiation; and (7) multinucleated giant cells.
  • Squamous differentiation and tubular formations were observed.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Anaplasia. Cell Differentiation. Female. Giant Cells / pathology. Humans. Immunohistochemistry. Middle Aged. Necrosis. Neoplasm Invasiveness. Predictive Value of Tests

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Bu XD, Li N, Tian XQ, Li L, Wang JS, Yu XJ, Huang PL: Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma. World J Gastroenterol; 2010 Aug 28;16(32):4089-94
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  • Six samples of normal mucosa (NM), 12 samples of hyperplastic polyp (HP), 15 samples of tubular adenoma with low-grade dysplasia (LGD), 14 samples of tubular adenoma with high-grade dysplasia (HGD), 26 samples of conventional colorectal adenocarcinoma (CCA), 15 samples of mucinous carcinoma (MC), and 8 samples of signet-ring cell carcinoma (SRCC) were collected.
  • The transformation process in MC and SRCC may be different from that in the traditional adenoma-carcinoma sequence.

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  • (PMID = 20731025.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucin 5AC; 0 / Mucin-2
  • [Other-IDs] NLM/ PMC2928465
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96. El Demellawy D, Daya D, Alowami S: Vulvar apocrine tubular adenoma: an unusual location. Int J Gynecol Pathol; 2008 Apr;27(2):301-3
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  • [Title] Vulvar apocrine tubular adenoma: an unusual location.
  • [MeSH-major] Adenoma / diagnosis. Skin Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis

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  • (PMID = 18356683.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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97. Matusan K, Dordevic G, Mozetic V, Lucin K: Expression of osteopontin and CD44 molecule in papillary renal cell tumors. Pathol Oncol Res; 2005;11(2):108-13
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  • [Title] Expression of osteopontin and CD44 molecule in papillary renal cell tumors.
  • The aim of the study was to analyze the expression of CD44 adhesion molecule and its ligand osteopontin in papillary renal cell tumors, and to assess the possible prognostic significance of CD44 and osteopontin expression in papillary renal cell carcinomas.
  • The expression of the standard and v6 exon containing isoforms of CD44 molecule, as well as of its ligand osteopontin, was immunohistochemically evaluated in 43 papillary renal cell tumors, which included 5 adenomas and 38 carcinomas.
  • In order to assess their prognostic significance, the results obtained in papillary renal cell carcinomas were compared to usual clinicopathological parameters such as tumor size, histological grade, pathological stage, and Ki-67 proliferation index.
  • Normal renal tissue was negative for CD44s and v6 isoforms, while the expression of osteopontin was found in distal tubular epithelial cells in the form of cytoplasmic granular positivity.
  • Papillary renal cell adenomas were generally negative for CD44s, except for focal positivity found in one sample.
  • The osteopontin protein was detected in all adenomas and all papillary renal cell carcinomas, except one.
  • Our results show constitutive expression of osteopontin in papillary renal tumors, including papillary renal cell adenomas.
  • The upregulation of CD44s and v6 isoforms, although found in a considerable number of papillary renal cell carcinomas, does not appear to have any prognostic value in this type of renal cancer.
  • [MeSH-major] Antigens, CD44 / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Papillary / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Sialoglycoproteins / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Female. Humans. Kidney / metabolism. Kidney / pathology. Male. Neoplasm Staging. Osteopontin

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  • (PMID = 15999156.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin
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98. Terao H, Matsumoto T, Umemoto S, Onuki T, Kobayashi K, Ohgo Y, Nogcchi S, Kishi H, Tsuura Y, Nagashima Y: [Metanephric adenoma: report of two cases]. Hinyokika Kiyo; 2008 Sep;54(9):599-602
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  • [Title] [Metanephric adenoma: report of two cases].
  • We report 2 cases of metanephric adenoma a rare form of adenoma.
  • One case occurred in a 54-year-old male preoperatively diagnosed with renal cell carcinoma who underwent left partial nephrectomy for a tumor 2 cm in size.
  • Thus, the patient was diagnosed with metanephric adenoma.
  • Incidental micronodules 2 mm in size and consisting of immature tubular structures were noted in the renal cortex.
  • In immunohistochemical staining, tumor cells were positive for CD57 and WT-1, and the patient was diagnosed with metanephric adenoma.
  • Preoperative differentiation of renal cell carcinoma and nephroblastoma is difficult.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 18975573.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / WT1 Proteins
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99. Beach R, Chan AO, Wu TT, White JA, Morris JS, Lunagomez S, Broaddus RR, Issa JP, Hamilton SR, Rashid A: BRAF mutations in aberrant crypt foci and hyperplastic polyposis. Am J Pathol; 2005 Apr;166(4):1069-75
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  • We evaluated BRAF mutations by DNA sequencing in 53 ACF from patients with sporadic colorectal carcinomas and familial adenomatous polyposis, in 18 sporadic HPs from patients with resected colorectal cancer, and in 70 HPs, 4 serrated adenomas, 3 admixed hyperplastic-adenomatous polyps, 10 tubular adenomas, and 6 carcinomas from 17 patients with multiple/large HPs and/or hyperplastic polyposis.
  • In contrast, BRAF mutation was present in 43% of HPs (P = 0.01 versus sporadic HPs), 75% of serrated adenomas, 33% of admixed hyperplastic-adenomatous polyps, 30% of tubular adenomas, and 33% of carcinomas from patients with multiple/large HPs and/or hyperplastic polyposis.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Aged. Aged, 80 and over. Base Sequence. Female. Humans. Intestinal Mucosa. Intestinal Polyps / genetics. Male. Middle Aged. Molecular Sequence Data

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  • (PMID = 15793287.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Other-IDs] NLM/ PMC1602378
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100. Capo-chichi CD, Yeasky TM, Heiber JF, Wang Y, Barber GN, Xu XX: Explicit targeting of transformed cells by VSV in ovarian epithelial tumor-bearing Wv mouse models. Gynecol Oncol; 2010 Feb;116(2):269-75
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  • Then, we tested VSV oncolytic therapy using the immune competent Wv mice that develop tubular adenomas, benign tumor lesions derived from ovarian surface epithelial cells.
  • Some variation in killing time courses was observed, but all the transformed cell lines were killed within 3 days.
  • CONCLUSIONS: VSV oncolytic activity depends on a cell autonomous property distinguishing primary and transformed cells.

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
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  • (PMID = 19932656.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA083638-100010; United States / NCI NIH HHS / CA / R01 CA079716-11; United States / NCI NIH HHS / CA / CA095924-06; United States / NCI NIH HHS / CA / R01 CA099471-05; United States / NCI NIH HHS / CA / R01 CA095924-05; United States / NCI NIH HHS / CA / R01 CA79716; United States / NCI NIH HHS / CA / R01 CA099471; United States / NCI NIH HHS / CA / R01 CA75389; United States / NCI NIH HHS / CA / R01 CA079716; United States / NIAID NIH HHS / AI / R01 AI071193-01A2; United States / NIAID NIH HHS / AI / R01 AI071193; United States / NCI NIH HHS / CA / CA095924-05; United States / NCI NIH HHS / CA / CA083638-100010; United States / NCI NIH HHS / CA / CA128115-01A2; United States / NCI NIH HHS / CA / R01 CA095924-06; United States / NCI NIH HHS / CA / P01 CA128115-01A2; United States / NCI NIH HHS / CA / CA079716-11; United States / NIAID NIH HHS / AI / AI071193-01A2; United States / NCI NIH HHS / CA / P01 CA128115; United States / NCI NIH HHS / CA / P50 CA083638; United States / NIAID NIH HHS / AI / R01 AI079336; United States / NCI NIH HHS / CA / R01 CA095924; United States / NCI NIH HHS / CA / CA099471-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS161338; NLM/ PMC2813895
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