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1. Psofaki V, Kalogera C, Tzambouras N, Stephanou D, Tsianos E, Seferiadis K, Kolios G: Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas. World J Gastroenterol; 2010 Jul 28;16(28):3553-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.
  • METHODS: DNA of healthy individuals, adenoma (tubular or villous/tubulovillous) patients, and colorectal carcinoma patients who underwent colonoscopy was used for assessing the prevalence of aberrant DNA methylation of human DNA mismatch repair gene mutator L homologue 1 (hMLH1), Cyclin-dependent kinase inhibitor 2A (CDKN2A/p16), and O-6-methylguanine DNA methyltransferase (MGMT), as well as their relation to MSI.
  • RESULTS: The frequency of promoter methylation for each locus increased in the sequence healthy tissue/adenoma/carcinoma.
  • MGMT and CDKN2A/p16 presented a statistically significant increase in promoter methylation between the less and more tumorigenic forms of colorectal adenomas (tubular vs tubullovillous and villous adenomas).
  • All patients with tubulovillous/villous adenomas, as well as all colorectal cancer patients, showed promoter methylation in at least one of the examined loci.
  • These findings suggest a potentially crucial role for methylation in the polyp/adenoma to cancer progression in colorectal carcinogenesis.
  • CONCLUSION: Methylation analysis of hMLH1, CDKN2A/p16, and MGMT revealed specific methylation profiles for tubular adenomas, tubulovillous/villous adenomas, and colorectal cancers, supporting the use of these alterations in assessment of colorectal tumorigenesis.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation / physiology. DNA Modification Methylases / genetics. DNA Repair Enzymes / genetics. Nuclear Proteins / genetics. Promoter Regions, Genetic / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 20653064.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
  • [Other-IDs] NLM/ PMC2909555
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2. Imperiale TF, Glowinski EA, Lin-Cooper C, Larkin GN, Rogge JD, Ransohoff DF: Five-year risk of colorectal neoplasia after negative screening colonoscopy. N Engl J Med; 2008 Sep 18;359(12):1218-24
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  • METHODS: We identified persons with no adenomas on baseline screening colonoscopy who returned at 5 years for follow-up colonoscopy.
  • Findings were categorized according to the most advanced lesion present: no polyp, a hyperplastic polyp, a tubular adenoma less than 1 cm in diameter, an advanced adenoma (a tubular adenoma > or = 1 cm in diameter or a polyp with villous histologic features or high-grade dysplasia), or a cancer.
  • RESULTS: Baseline screening colonoscopy had identified 2436 persons with no adenomas; 1256 of them (51.6%) were rescreened a mean (+/-SD) of 5.34+/-1.34 years later.
  • One or more adenomas were found in 201 persons (16.0%).
  • A total of 19 advanced adenomas, of which 10 (52.6%) were distal to the splenic flexure, were found in 16 persons (1.3%).
  • The risk of an advanced adenoma did not differ significantly between persons with no polyps at baseline and those with hyperplastic polyps at baseline (1.1% [12 of 1057] and 2.0% [4 of 199], respectively; P=0.30).
  • Men were more likely than women to have any adenoma (tubular less than 1 cm in diameter or advanced) (relative risk, 1.88; 95% CI, 1.42 to 2.51) and to have an advanced adenoma (relative risk, 3.31; 95% CI, 1.02 to 10.8).
  • The risk of advanced adenoma is also low, although it is higher among men than among women.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Colonic Polyps / epidemiology. Colonoscopy. Colorectal Neoplasms / epidemiology

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  • [Copyright] 2008 Massachusetts Medical Society
  • [CommentIn] N Engl J Med. 2008 Dec 11;359(24):2611; author reply 2612 [19090029.001]
  • [CommentIn] N Engl J Med. 2008 Dec 11;359(24):2611; author reply 2612 [19073983.001]
  • [CommentIn] N Engl J Med. 2008 Sep 18;359(12):1285-7 [18799563.001]
  • [CommentIn] N Engl J Med. 2008 Dec 11;359(24):2611-2; author reply 2612 [19090030.001]
  • [ErratumIn] N Engl J Med. 2009 Nov 12;361(20):2004
  • (PMID = 18799558.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K24 DK02756
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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3. Krutsay M, Chanis W: [Retroperitoneal adenoma]. Magy Onkol; 2007;51(1):63-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Retroperitoneal adenoma].
  • [Transliterated title] Retroperitonealis adenoma.
  • On histological examination the lipid-rich tumor was found to be partly a solid adrenocortical adenoma and partly a tubular oncocytoma.
  • [MeSH-major] Adenoma / diagnosis. Adenoma, Oxyphilic / diagnosis. Adrenal Cortex Neoplasms / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 17417677.001).
  • [ISSN] 0025-0244
  • [Journal-full-title] Magyar onkologia
  • [ISO-abbreviation] Magy Onkol
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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4. Colović R, Grubor N, Radak V, Micev M, Colović N, Stojković M: [Tubular adenoma of the gallbladder with squamous metaplasia]. Srp Arh Celok Lek; 2006 Mar-Apr;134(3-4):159-61
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  • [Title] [Tubular adenoma of the gallbladder with squamous metaplasia].
  • Adenomas of the gallbladder are rare tumors.
  • They may be papillar or tubular.
  • Tubular adenoma appears in middle aged and older patients, although it may develop even in children.
  • Histology showed tubular adenoma with mild epithelial dysplasia in some places and with antral and squamous metaplasia.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 16915759.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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5. Riaz N, Khan SM, Idrees R, Kayani N: Infiltrating syringomatous adenoma of nipple. J Coll Physicians Surg Pak; 2008 Jul;18(7):438-9
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  • [Title] Infiltrating syringomatous adenoma of nipple.
  • Infiltrating syringomatous adenoma of the nipple is a rare, benign lesion with distinct clinical and histological features.
  • Important differential diagnosis include nipple adenoma, tubular carcinoma and adenosquamous carcinoma.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Nipples

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  • (PMID = 18760070.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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6. Tabuchi M, Kitayama J, Nagawa H: Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men. World J Gastroenterol; 2006 Feb 28;12(8):1261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men.
  • METHODS: We performed a large scale retrospective study to analyze the correlation between the incidence of colorectal adenoma or carcinoma and the fasting serum levels of total cholesterol (TC) and triglycerides (TG) in patients who underwent total colonoscopy for screening for colon cancer.
  • RESULTS: Both levels were significantly elevated in patients with adenomas as compared with patients without any neoplastic lesion (TC 207.6+/-29.5 vs 199.5+/-34.3, n=4883, P<0.001; TG 135.0+/-82.2 vs 108.7+/-71.5, n=4874, P<0.001).
  • The difference was significant in patients with tubular adenoma but not in those with villous or serrated adenoma.
  • The level of TG in patients with invasive carcinoma did not show a significant elevation from that in patients with adenoma.
  • These findings suggest that hypertriglyceridemia is an independent risk factor for colonic adenoma in men.
  • [MeSH-major] Adenoma / blood. Adenoma / etiology. Colorectal Neoplasms / blood. Colorectal Neoplasms / etiology. Hypertriglyceridemia / complications

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  • (PMID = 16534881.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
  • [Other-IDs] NLM/ PMC4124439
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7. Al-Daraji WI, Abdellaoui A, Salman WD: Osseous metaplasia in a tubular adenoma of the colon. J Clin Pathol; 2005 Feb;58(2):220-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osseous metaplasia in a tubular adenoma of the colon.
  • The polyp was a tubular adenoma with mild dysplasia.
  • The adenoma contained numerous foci of metaplastic bone.
  • This is the first case of osseous metaplasia in a tubular adenoma of the colon to be reported.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Ossification, Heterotopic / pathology

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  • (PMID = 15677548.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770563
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8. Kim HD, Oh YS, Kim SH, Kim SP, Shin HH, Park JY, Park H, Myoung BH, Kim DH, Lee YJ, Kim HR, Jung YD: [Telomerase expression in colorectal tubular adenoma determined by immunohistochemical staining]. Korean J Gastroenterol; 2007 Sep;50(3):164-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Telomerase expression in colorectal tubular adenoma determined by immunohistochemical staining].
  • In this study, we compared the telomerase expression between low grade and high grade colorectal tubular adenoma.
  • METHODS: Among tissues from forty eight patients with colorectal tubular adenoma (23 low grade and 25 high grade colorectal dysplasia), telomerase expressions were evaluated by immunohistochemical staining.
  • High telomerase expression was a group which showed staining nucleus pattern above 50% in tubular adenoma.

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  • (PMID = 17885281.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] EC 2.7.7.49 / Telomerase
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9. Hetzel JT, Huang CS, Coukos JA, Omstead K, Cerda SR, Yang S, O'Brien MJ, Farraye FA: Variation in the detection of serrated polyps in an average risk colorectal cancer screening cohort. Am J Gastroenterol; 2010 Dec;105(12):2656-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Polyps were classified as adenoma (tubular, tubulovillous, or villous), serrated polyp (hyperplastic polyp (HP), sessile serrated adenoma (SSA), or dysplastic serrated polyp (DSP)), adenocarcinoma, or other.
  • Detection prevalence (patients with at least one polyp per 100 colonoscopies) was 22.2 for adenomas, 11.7 for HP, 0.6 for SSA, and 0.2 for DSP.
  • Detection prevalences among endoscopists differed significantly for adenomas, HP, and SSA.
  • Classification rates among pathologists differed significantly for HP and SSA, but not for adenoma or DSP.
  • On multivariate analysis, endoscopist was a significant predictor of adenoma, HP, and SSA.
  • Pathologist was a significant predictor of HP, SSA, and DSP, but not adenoma.
  • Detection of adenoma, HP, and SSA differed significantly by endoscopist.
  • Classification of HP and SSA differed significantly by pathologist.
  • Endoscopy and pathology practices should consider educational interventions to improve serrated polyp detection and standardize classification.


10. Kushima R, Vieth M: [Tubular adenoma of the stomach with special reference to the Japanese criteria and pyloric gland adenoma]. Pathologe; 2010 May;31(3):177-81
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  • [Title] [Tubular adenoma of the stomach with special reference to the Japanese criteria and pyloric gland adenoma].
  • [Transliterated title] Das tubuläre Magenadenom. Mit Darstellung der Japanischen Kriterien unter Berücksichtigung des "pyloric gland adenoma"
  • The term gastric adenoma usually refers to a flat adenoma of the intestinal type.
  • Adenomas of the gastric type, so-called pyloric gland adenomas (PGA), which was first characterized by German and Japanese pathologists in 1990, have been regarded as exceptional until recently.
  • In this article we introduce the Japanese criteria of the gastric adenoma and review and discuss the clinical pathological and molecular aspects of PGAs.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Intestinal Neoplasms / genetics. Intestinal Neoplasms / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology

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  • (PMID = 20349063.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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11. Turrini R, Lanzani G, Salmi A: [Gallbladder adenoma with focal adenocarcinoma: a case report]. Recenti Prog Med; 2007 Oct;98(10):506-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gallbladder adenoma with focal adenocarcinoma: a case report].
  • [Transliterated title] Adenoma con focale adenocarcinoma della colecisti: descrizione di un caso.
  • Video-laparoscopic cholecystectomy was performed, and histological examination of the lesion revealed a severely dysplastic tubular adenoma and chronic cholecystitis.
  • To our knowledge, this is the first report of a gallbladder polyp already presenting severe dysplasia in a young Caucasian male without risk factors.
  • [MeSH-major] Adenoma / diagnosis. Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / diagnosis. Polyps / complications

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  • (PMID = 17970176.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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12. Ravindra S, Suguna BV: Cytomorphology of tubular adenoma breast--a case report. Indian J Pathol Microbiol; 2006 Apr;49(2):267-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphology of tubular adenoma breast--a case report.
  • Tubular adenoma a 'pure adenoma' is a benign neoplasm of breast presenting clinically like fibroadenoma.
  • We report cytological and histological features of tubular adenoma in a 24 year old female with brief review of literature.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology

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  • (PMID = 16933735.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 7
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13. Wu WX, Duan YY, Lü GH, Shi SF, Zhang JY, Wang HS, Zhang XH: [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Zhonghua Zhong Liu Za Zhi; 2010 Sep;32(9):671-5
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  • [Title] [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma].
  • OBJECTIVE: To study the possible role of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma.
  • METHODS: Immunohistochemical staining was used to detect the expression of JNK1, Raf-1 and Livin proteins in 65 sporadic colorectal tubular adenomas with dysplasia of varying degrees and 22 colorectal tubular adenoma with cancerous area.
  • RESULTS: In normal colorectal mucosa, colorectal tubular adenoma with dysplasia and colorectal tubular adenoma with cancerous area, the positive rate of JNK1, Raf-1 and Livin expression was increased gradually.
  • The positive expression of JNK1, Raf-1 and Livin was all significantly higher in the cases of colorectal tubular adenoma with dysplasia or with cancerous area than that in normal colorectal mucosa (P < 0.05), and the positive expression of JNK1, Raf-1 and Livin was significantly higher in colorectal tubular adenoma with cancerous area than that in colorectal tubular adenoma with dysplasia of different degrees (P < 0.05).
  • In the cases of colorectal tubular adenoma with dysplasia of varying degrees, the positive expression of Raf-1 was increased along with the increasing dysplasia degree of colorectal tubular adenoma (P < 0.05).
  • Coexpression of JNK1, Raf-1 and Livin increased gradually in the carcinogenesis of sporadic colorectal tubular adenoma, while positive correlation was found among the expressions of JNK1, Raf-1 and Livin.
  • CONCLUSION: JNK1, Raf-1 and Livin may be involved in the carcinogenesis of sporadic colorectal tubular adenoma.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / metabolism. Adenoma / pathology. Cell Transformation, Neoplastic. Colorectal Neoplasms / pathology. Inhibitor of Apoptosis Proteins / metabolism. Mitogen-Activated Protein Kinase 8 / metabolism. Neoplasm Proteins / metabolism. Proto-Oncogene Proteins c-raf / metabolism

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  • (PMID = 21122381.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BIRC7 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Neoplasm Proteins; EC 2.7.11.1 / Proto-Oncogene Proteins c-raf; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 8
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14. Liu HM, Wu WX, Zhang XH, Lü GH, Zhang JY: [Expressions and significance of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma]. Zhonghua Zhong Liu Za Zhi; 2007 Jul;29(7):514-7
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  • [Title] [Expressions and significance of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma].
  • OBJECTIVE: To investigate the possible role of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma.
  • METHODS: The expression of STAT3 and p38 at protein level was studied in 107 sporadic colorectal tubular adenomas with different dysplasia (SCTA-D) or with cancerous changes (SCTA-Ca) by immunohistochemical staining method, meanwhile the expression of STAT3 at mRNA level was detected by in situ hybridization.
  • CONCLUSION: STAT3 and p38 may be involved in the carcinogenesis of sporadic colorectal tubular adenoma.
  • [MeSH-major] Adenoma / metabolism. Colorectal Neoplasms / metabolism. Precancerous Conditions / metabolism. STAT3 Transcription Factor / metabolism. p38 Mitogen-Activated Protein Kinases / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Cell Transformation, Neoplastic / metabolism. Gene Expression Regulation, Neoplastic. Humans. Intestinal Mucosa / metabolism. RNA, Messenger / metabolism

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  • (PMID = 18069631.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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15. Sztarkier I, Levy I, Walfisch S, Delgado J, Benharroch D: Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma. Ann Diagn Pathol; 2009 Feb;13(1):47-9
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  • [Title] Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma.
  • A bone marrow biopsy showed malignant lymphoma, suggestive of mantle cell lymphoma (MCL).
  • Colonoscopy at this time revealed 3 colonic tubular adenomas.
  • Reassessment of the histology of the colonic polyps and appropriate immunohistochemical stains showed that the lamina propria of one of the tubular adenomas was infiltrated by MCL.
  • To our knowledge, this is the fifth reported case of synchronous occurrence of intestinal MCL and colonic carcinoma and the first report of MCL presenting in a tubular adenoma of the colon.
  • [MeSH-major] Adenocarcinoma / diagnosis. Lymphoma, Mantle-Cell / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sigmoid Neoplasms / diagnosis

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  • (PMID = 19118782.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Armah HB, Krasinskas AM, Parwani AV: Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case. Diagn Pathol; 2007;2:29

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  • [Title] Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case.
  • We present the case of a 39-year-old male with a tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty to enlarge a post-chemoradiation-induced shrunken bladder.
  • Histologic examination revealed a tubular adenoma with high-grade dysplasia.
  • There are only two previous reports of tubulovillous adenoma in ileal segment after ileocystoplasty, both without high-grade dysplasia.
  • Our observation supports the hypothesis that an ileal neobladder may undergo all the morphologic and molecular changes observed in the development of gastrointestinal adenocarcinoma.

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  • [Cites] J Urol. 2002 Jan;167(1):84-8 [11743281.001]
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  • (PMID = 17697327.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1995190
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17. Lee CH, Bang SH, Lee SK, Song KY, Lee IC: Gene expression profiling reveals sequential changes in gastric tubular adenoma and carcinoma in situ. World J Gastroenterol; 2005 Apr 7;11(13):1937-45
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  • [Title] Gene expression profiling reveals sequential changes in gastric tubular adenoma and carcinoma in situ.
  • METHODS: We analyzed the expression profiles of normal gastric pit, tubular adenoma and carcinoma in situ using microdissected cells from routine gastric biopsies.
  • RESULTS: In comparison with normal pit, adenoma/carcinoma showed 504 up-regulated and 29 down-regulated genes at the expected false significance rate 0.15%.
  • The differential expression between adenoma and carcinoma in situ was subtle: 50 and 22 genes were up-, and down-regulated in carcinomas at the expected false significance rate of 0.61%, respectively.
  • Differentially expressed genes were grouped according to patterns of the sequential changes for the 'tendency analysis' in the gastric mucosa-adenoma-carcinoma sequence.
  • [MeSH-minor] Aged. Animals. Cell Line, Tumor. Female. Humans. Male. Mice. Mice, Nude. Middle Aged. Neoplasm Transplantation. Precancerous Conditions / genetics. Precancerous Conditions / pathology. Transplantation, Heterologous

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  • (PMID = 15800983.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4305714
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18. Chetty R, Serra S: Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm. Histopathology; 2009 Sep;55(3):270-6
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  • [Title] Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm.
  • AIMS: Intraductal tubular adenoma (ITA) is an uncommon intraluminal polypoid lesion that occurs in the main pancreatic duct and involves the main pancreatic duct in the region of head or body.
  • METHODS AND RESULTS: ITA is composed of tightly packed tubular structures with focal cystic dilation and papillary areas lined by gastric/pyloric epithelium showing minimal to mild cytological atypia.
  • ITA could represent a localized, polypoid form of gastric-type IPMN.It is a benign lesion with no evidence of invasion and no direct tumour-related deaths.
  • Its relationship to intraductal tubular carcinoma remains to be elucidated.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Adenoma / pathology. Carcinoma in Situ / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • [CommentIn] Histopathology. 2010 Jun;56(7):968-9; author reply 969 [20636797.001]
  • (PMID = 19723141.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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19. Uriev L, Maslovsky I, Vainshtein P, Yoffe B, Ben-Dor D: Malignant phyllodes tumor with heterologous liposarcomatous differentiation and tubular adenoma-like epithelial component. Int J Med Sci; 2006;3(4):130-4

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  • [Title] Malignant phyllodes tumor with heterologous liposarcomatous differentiation and tubular adenoma-like epithelial component.
  • A 30-year-old woman presented with a 1-year history of a palpable, asymptomatic right breast mass without axillary lymphadenopathy and family history of breast carcinoma.
  • The authors present not previously described histological appearance of this tumor where an epithelial component was identical to that of a tubular adenoma of the breast, with the review of the literature.

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  • [Cites] Arch Pathol Lab Med. 2005 Mar;129(3):421-2 [15737047.001]
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  • (PMID = 17003843.001).
  • [ISSN] 1449-1907
  • [Journal-full-title] International journal of medical sciences
  • [ISO-abbreviation] Int J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Other-IDs] NLM/ PMC1570617
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20. Kazakov DV, Mukensnabl P, Michal M: Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol; 2006 Apr;28(2):142-6
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  • [Title] Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
  • The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues.
  • We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation.
  • The features in both cases indicated apocrine differentiation of the tubular component.
  • One patient was a 60-year-old woman with a 1-year history of a solitary nodule on the scalp.
  • The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia.
  • In both cases, the areas with immature squamous metaplasia were represented by solid nodules that were mostly devoid of lumens and a peripheral basal/myoepithelial cell layer.
  • In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation.
  • [MeSH-major] Adenoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Back. Cell Differentiation. Cell Lineage. Eosinophils / pathology. Epithelial Cells / pathology. Epithelium / pathology. Female. Fibroblasts / pathology. Follow-Up Studies. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Humans. Middle Aged. Scalp / pathology. Sebaceous Glands / pathology

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  • (PMID = 16625077.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Shimomura T, Hiyama T, Tanaka S, Yoshihara M, Arihiro K, Chayama K: Synchronous and subsequent lesions of serrated adenomas and tubular adenomas of the colorectum. Pathobiology; 2010;77(5):273-7
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  • [Title] Synchronous and subsequent lesions of serrated adenomas and tubular adenomas of the colorectum.
  • The characteristics of synchronous and subsequent lesions of serrated adenomas (SAs) of the colorectum are still unclear.
  • This study aimed to clarify the characteristics of synchronous and subsequent lesions of SAs compared with tubular adenomas (TAs) of the colorectum.
  • [MeSH-major] Adenoma / pathology. Colon / pathology. Colorectal Neoplasms / pathology. Rectum / pathology

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21116119.001).
  • [ISSN] 1423-0291
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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22. Kazakov DV, Bisceglia M, Calonje E, Hantschke M, Kutzner H, Mentzel T, Michal M, Mukensnabl P, Spagnolo DV, Rütten A, Rose C, Urso C, Vazmitel M, Zelger B: Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists. Am J Dermatopathol; 2007 Jun;29(3):256-63
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  • [Title] Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists.
  • Tubular adenoma (TA) and syringocystadenoma papilliferum (SCAP) may show histopathological overlap, with some lesions having features of both neoplasms (SCAP + TA).
  • Four observers blindly assessed 67 cases of TA, SCAP, and their lookalikes (poroma, apocrine adenoma, apocrine carcinoma; all lesions focally featuring a pseudopapillary pattern), and classified the lesions into one of four categories:.
  • Lesions were also classified as benign or malignant.
  • Analysis of the factors leading to interobserver variability indicated that diagnostic problems occurred when there were any of the following: epidermal acanthosis, papillomatosis, connection of the neoplastic tubules to the overlying epidermis and/or follicular infundibula, and plasma cell infiltration.
  • All observers agreed that the lesions were benign; the only apocrine carcinoma included was recognized as such by all observers.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Cystadenoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17519623.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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23. Bukhari MH, Salaria SM, Niaz Z, Muzzafar A, Batool Z, Qureshi GR, Naveed IA, Chaudhry NA: Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice. J Coll Physicians Surg Pak; 2006 Apr;16(4):280-3
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  • [Title] Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice.
  • OBJECTIVE: To determine the mutation of p53 in chemically induced carcinogenesis on albino mice in skin papilloma and tubular adenoma breast by immunohistochemistry.
  • SUBJECTS AND METHODS: Twenty five albino mice (male and female) were selected for a study on chemical carcinogenesis.
  • Squamous cell papillomas and tubular adenoma breast were selected for this study.
  • RESULTS: All the papillomas showed faint reactivity for immunomarker p53, while tubular adenomas were nonreactive.
  • [MeSH-major] Adenoma / genetics. Biomarkers, Tumor / analysis. Breast Neoplasms / genetics. Genes, p53. Mutation. Papilloma / genetics

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  • (PMID = 16624193.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Itatsu K, Sano T, Hiraoka N, Ojima H, Takahashi Y, Sakamoto Y, Shimada K, Kosuge T: Intraductal tubular carcinoma in an adenoma of the main pancreatic duct of the pancreas head. J Gastroenterol; 2006 Jul;41(7):702-5
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  • [Title] Intraductal tubular carcinoma in an adenoma of the main pancreatic duct of the pancreas head.
  • Microscopically, the tumor was an intraductal tubular carcinoma (ITC) in a tubular adenoma, suggesting direct histologic evidence of the adenoma-carcinoma sequence in intraductal tubular tumors, differing from previous reports of ITCs describing de novo-like development.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 16933009.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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25. Nakayama Y, Inoue H, Hamada Y, Takeshita M, Iwasaki H, Maeshiro K, Iwanaga S, Tani H, Ryu S, Yasunami Y, Ikeda S: Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol; 2005 May;29(5):607-16
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  • [Title] Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases.
  • The intraductal tubular adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type adenoma of the gallbladder.
  • Microscopically, the tumors were composed of closely packed tubular glands resembling pyloric type glands.
  • In 2 cases, the adjacent pancreas showed foci of intraductal papillary-mucinous adenoma.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. DNA-Binding Proteins / analysis. Epithelial Cells / pathology. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Mucins / analysis. Mucins / classification. Pancreaticoduodenectomy. Pepsinogen A / analysis. Smad4 Protein. Trans-Activators / analysis. Treatment Outcome. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15832084.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Mucins; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 9001-10-9 / Pepsinogen A
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26. Chebib I, Beck PL, Church NG, Medlicott SA: Gastric pouch adenocarcinoma and tubular adenoma of the pylorus: a field effect of dysplasia following bariatric surgery. Obes Surg; 2007 Jun;17(6):843-6
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  • [Title] Gastric pouch adenocarcinoma and tubular adenoma of the pylorus: a field effect of dysplasia following bariatric surgery.
  • We present a case of a 60-year-old man who, 15 years after vertical banded gastroplasty (VBG), had a massive upper GI bleed.
  • An incidental tubular adenoma at the pylorus was also identified.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Gastroplasty. Postoperative Complications. Stomach Neoplasms / etiology

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  • [ErratumIn] Obes Surg. 2007 Jul;17(7):996
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  • (PMID = 17879590.001).
  • [ISSN] 0960-8923
  • [Journal-full-title] Obesity surgery
  • [ISO-abbreviation] Obes Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Rovera F, Ferrari A, Carcano G, Dionigi G, Cinquepalmi L, Boni L, Diurni M, Dionigi R: Tubular adenoma of the breast in an 84-year-old woman: report of a case simulating breast cancer. Breast J; 2006 May-Jun;12(3):257-9
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  • [Title] Tubular adenoma of the breast in an 84-year-old woman: report of a case simulating breast cancer.
  • Tubular adenomas of the breast are rare and they mainly occur in young women.
  • They must be differentiated from other benign lesions and from malignant breast cancer.
  • This article describes a case of an 84-year-old woman suffering from tubular adenoma of the breast.
  • The authors underline the difficulty in preoperative differentiation between benign and malignant breast lesions.
  • [MeSH-major] Adenoma / diagnosis. Breast Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Breast / pathology. Breast Diseases / diagnosis. Diagnosis, Differential. Female. Humans. Mammography. Ultrasonography, Mammary

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  • (PMID = 16684324.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Sato Y, Osaka H, Harada K, Sasaki M, Nakanuma Y: Intraductal tubular neoplasm of the common bile duct. Pathol Int; 2010 Jul;60(7):516-9
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  • [Title] Intraductal tubular neoplasm of the common bile duct.
  • In this report, a rare case of intraductal tubular neoplasm (ITN) arising in the common bile duct is presented.
  • Histology of the lesion revealed tubular neoplasm, composed of an admixture of tubular glands resembling pyloric gland adenoma with minimal atypia (low-grade tubular adenoma), and those resembling intestinal type tubular adenoma (high-grade tubular adenoma).
  • On immunostaining low-grade tubular adenoma was positive for MUC5AC and MUC6, and negative for MUC2 and cytokeratin (CK) 20, while high-grade tubular adenoma and carcinoma in situ were positive for MUC2 and CK20, and negative for MUC5AC.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Common Bile Duct / pathology

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  • (PMID = 20594273.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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29. Shi C, Scudiere JR, Cornish TC, Lam-Himlin D, Park JY, Fox MR, Montgomery EA: Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. Am J Surg Pathol; 2010 Sep;34(9):1344-50
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  • [Title] Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile.
  • Clear cell change is seen in <1% of colonic tubular adenomas (TAs) and remains incompletely characterized.
  • Associated adenocarcinomas can also demonstrate a clear cell phenotype.
  • Eleven TAs with at least focal clear cell change with or without associated invasive adenocarcinoma, from 10 patients were studied.
  • Eight of 11 (77%) TAs with clear cell change had focal to extensive high-grade dysplasia.
  • Two were associated with invasive clear cell adenocarcinoma.
  • The adenomas and adenocarcinomas ranged from 0.5 to 3.5 cm.
  • On immunohistochemical studies, the clear cells had decreased MUC2 labeling compared with the surrounding conventional adenoma in 9 of 11 (88%) cases, including the 2 clear cell adenocarcinomas.
  • In 3 of the 11 lesions, the background TA showed at least focal MUC5 immunoreactivity, their associated clear cell area had decreased MUC5 labeling in all 3 cases.
  • One of the clear cell adenocarcinomas was CK20, CK7, CDX2 and the other was CK20, CK7, CDX2-focal positive.
  • Thus, although the clear cells have different MUC protein profiles than the background adenomatous epithelium, invasive clear cell adenocarcinomas retained the typical CK20(+)/CK7(-) profile of conventional adenocarcinomas.
  • Our results indicate that clear cell adenocarcinomas can be primary to the colorectum with identifiable precursors.
  • Awareness of them and their immunoprofile allows distinction from clear cell lesions from other sites.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenoma / pathology. Colonic Neoplasms / pathology. Mucins / metabolism. Rectal Neoplasms / pathology

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  • (PMID = 20697252.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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30. Guan J, Chen J, Luo YF, Cao JL, Zhao H, Hao J: [Expression of survivin in colorectal adenoma and adenocarcinoma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2007 Jun;29(3):398-401
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  • [Title] [Expression of survivin in colorectal adenoma and adenocarcinoma].
  • METHODS Immunohistochemistry staining was performed by two-step EnVision technique for the paraffin sections, which included 90 adenomas, 25 ademomas with high-grade glandular intraepithelial neoplasia, and 108 colorectal adenocarcinomas.
  • The positive rate of SVV in tubular adenomas, villous adenomas, and tubulovillous adenomas were 30% (12/40), 40.9% (9/22), and 35.8% (10/28), respectively.
  • The positive rate of SVV in tubulovillous adenomas with high-grade glandular intraepithelial neoplasia were 68% (17/25).
  • SVV expressions among the three types of adenomas without neoplasia were not significantly different (P > 0.05).
  • SVV expression between each type of the above-mentioned ademoma and tubulovillous adenoma with high-grade glandular intraepithelial neoplasia or different Dukes stages of colorectal carcinoma was significantly different (P < 0.05).
  • SVV expressions in adenocarcinomas and adenomas with high grade glandular intraepithelial neoplasia were significantly higher than those in adenomas (P < 0.01).
  • SVV expression may be useful to distinguish adenocarcinoma from adenoma in colorectal carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Colorectal Neoplasms / metabolism. Microtubule-Associated Proteins / biosynthesis

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  • (PMID = 17633470.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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31. Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S: Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. BMC Cancer; 2008 Jan 29;8:33
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  • [Title] Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma.
  • METHODS: By immunohistochemistry, we assessed COX-2 expression in 24 hyperplastic polyps, 7 sessile serrated polyp/adenomas (SSA), 5 mixed polyps with SSA and adenoma, 27 traditional serrated adenomas, 515 non-serrated adenomas (tubular adenoma, tubulovillous adenoma and villous adenoma), 33 adenomas with intramucosal carcinomas, 96 adenocarcinomas with serration (corkscrew gland) and 111 adenocarcinomas without serration.
  • RESULTS: Strong (2+) COX-2 overexpression was more common in non-serrated adenomas (28% = 143/515) than in hyperplastic polyps (4.2% = 1/24, p = 0.008) and serrated polyps (7 SSAs and 5 mixed polyps) (0% = 0/12, p = 0.04).
  • Furthermore, any (1+/2+) COX-2 overexpression was more frequent in non-serrated adenomas (60% = 307/515) than in hyperplastic polyps (13% = 3/24, p < 0.0001) and serrated polyps (SSAs and mixed polyps) (25% = 3/12, p = 0.03).
  • Traditional serrated adenomas and non-serrated adenomas showed similar frequencies of COX-2 overexpression.
  • Tumor location was not significantly correlated with COX-2 overexpression, although there was a trend towards higher frequencies of COX-2 overexpression in distal tumors (than proximal tumors) among hyperplastic polyps, SSAs, mixed polyps, traditional serrated adenomas and adenocarcinomas.
  • CONCLUSION: COX-2 overexpression is infrequent in hyperplastic polyp, SSA and mixed polyp with SSA and adenoma, compared to non-serrated and serrated adenoma.

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  • (PMID = 18230181.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA087969; United States / NCI NIH HHS / CA / P01 CA055075; United States / NCI NIH HHS / CA / K07 CA122826; United States / NCI NIH HHS / CA / P01 CA87969; United States / NCI NIH HHS / CA / P01 CA55075; United States / NCI NIH HHS / CA / P50 CA127003
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  • [Other-IDs] NLM/ PMC2257954
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32. Radovanovic-Dinic B, Nagorni A, Katic V, Stamenkovic I, Zlatic A: An immunohistochemical study of Ki-67 in colorectal adenoma. Med Arh; 2009;63(1):16-8
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  • [Title] An immunohistochemical study of Ki-67 in colorectal adenoma.
  • INTRODUCTION: The expression of the human Ki-67 protein is strictly associated with cell proliferation.
  • The cell proliferation and kinetics of normal gastrointestinal tract are well known but the cell kinetics of adenoma in gastrointestinal tract is poorly understood.
  • The aim of this study was to provide an immunohistochemical evaluation of the expression of Ki-67 antigen in different colorectal adenomas.
  • MATERIAL AND METHODS: In the prospective study, we analyzed 65 colorectal adenomas.
  • RESULTS: Proliferation indexes were found to steadily increase from normal mucosa to adenoma (p < 0.05).
  • There was also a difference in the expression of Ki-67 between adenomas smaller and larger than 10 mm (p < 0.05).
  • The expression of Ki-67 was strongly more often in villous adenomas as opposed to the tubular adenomas (p < 0.05).
  • Reaction for Ki-67 were strong in adenomas with high grade atypia compared to low grade adenomas (p < 0.001).
  • CONCLUSION: The expression of Ki-67 clearly shows differences between advanced and nonadvanced adenomas.
  • The strong reactions of Ki-67 in adenomas with severe dysplasia show a close association with colorectal carcinoma.
  • [MeSH-major] Adenoma / metabolism. Colorectal Neoplasms / metabolism. Ki-67 Antigen / metabolism

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  • (PMID = 19419120.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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33. Amin W, Parwani AV: Nephrogenic adenoma. Pathol Res Pract; 2010 Oct 15;206(10):659-62
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  • [Title] Nephrogenic adenoma.
  • Nephrogenic adenoma is an uncommon benign lesion.
  • The proposal that nephrogenic adenoma originates from the implantation of exfoliated renal tubular cells is lately gaining wider acceptance.
  • The role of immunohistochemistry cannot be undermined in the diagnosis of nephrogenic adenoma, although histological diagnosis is usually conclusive.
  • The possibility of nephrogenic adenoma should always be in the differential diagnosis when evaluating patients with predisposed urinary tract symptoms.
  • [MeSH-major] Adenoma / pathology. Kidney Tubules / pathology. Urologic Neoplasms / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Humans. Immunohistochemistry. Predictive Value of Tests. Recurrence. Treatment Outcome. Urine / cytology

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20619548.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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34. Matthiessen MW, Pedersen G, Albrektsen T, Adamsen S, Fleckner J, Brynskov J: Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. Scand J Gastroenterol; 2005 Feb;40(2):198-205
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas.
  • OBJECTIVE: Peroxisome proliferator-activated receptor (PPAR) ligands, widely used in type 2 diabetes treatment, have variably been shown to promote or prevent colon tumor formation in animal models and cell lines, but their role in normal human colon is unknown.
  • The aim of this study was to determine PPAR expression and function in normal human colonic epithelial cells and tubular adenomas.
  • Cell viability was measured using the methyltetrazoleum assay, proliferation by thymidine incorporation, and DNA profiles by flow cytometry.
  • PPAR mRNA levels in tubular adenomas or metaplastic polyps (n=12) were compared with those in controls.
  • PPAR gamma activation had no effect on viability or DNA profiles, but led to a 25% significant decrease in cell proliferation.
  • Finally, a selective and significant 2.5-fold decrease in PPAR alpha expression was observed in tubular adenomas, but not in metaplastic polyps, compared to controls.
  • Moreover, they raise interest in investigation of PPAR alpha as a therapeutic target to prevent adenoma formation.
  • [MeSH-major] Adenoma / metabolism. Colonic Neoplasms / metabolism. Epithelial Cells / metabolism. Peroxisome Proliferator-Activated Receptors / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Cell Survival / physiology. Colon. Female. Humans. Male. Middle Aged

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  • (PMID = 15764152.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Peroxisome Proliferator-Activated Receptors
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35. Khamidullina GA, Kapuller LL, Sereda EN, Izbagambetov NA, Zharkov NV: [Small-cell rectal carcinoma coexisted with tubular-villous adenoma]. Arkh Patol; 2006 Sep-Oct;68(5):37-9
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  • [Title] [Small-cell rectal carcinoma coexisted with tubular-villous adenoma].
  • The paper describes a case of small-cell high-grade endocrine carcinoma of the rectum concurrent with tubular-villous adenoma in a 58 year-old woman.
  • All epithelial cells of adenoma have been ascertained to be "mixed" exoendocrine endocrinocytes (secrete mucus and contain neuroendocrine granules), contain progesterone receptors, and express CK 8, 18, and 19.
  • [MeSH-major] Adenoma, Villous / pathology. Carcinoma, Small Cell / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Cell Proliferation. Female. Humans. Keratin-18 / metabolism. Ki-67 Antigen / metabolism. Middle Aged. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17144530.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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36. Nguyen AV, Albers CG, Holcombe RF: Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. Int J Mol Med; 2010 Jul;26(1):121-5
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  • [Title] Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles.
  • This study was undertaken to define whether differences in the expression of Wnt pathway components are present between normal colonic mucosa, early (tubular) adenomas and villous adenomas which have a higher malignant potential.
  • Normal mucosa, tubular adenomas and villous adenomas were obtained from twelve patients.
  • Fifteen Wnt pathway-related genes showed differential expression between villous adenomas and normal mucosa and villous and tubular adenomas at a significance level of p<0.01.
  • Genes involved in canonical Wnt (beta-catenin) signaling with increased expression in villous adenomas included wnt1, fz2, csnk2A2, pygo2, pygo1, frat2 and myc, the latter confirmed by qRT-PCR and IHC.
  • Myc protein expression was confined primarily to stromal components of villous adenomas.
  • Genes involved in non-canonical Wnt signaling with increased expression in villous adenomas included rho-u, daam1, damm2, cxxc4 and nlk.
  • Successive increases in the expression of ctnnb1 (beta-catenin) from normal to tubular adenomas to villous adenomas was seen.
  • The Wnt pathway gene expression profile can differentiate between tubular and villous adenomas.
  • These data suggest that Wnt signaling regulation changes during the progression from normal mucosa to tubular adenomas to villous adenomas.
  • Expression of Myc in adenoma stroma suggests a dynamic signaling network within adenomas between mucosal and stromal elements.
  • Inhibition of the Wnt pathway may provide a novel approach for cancer prevention in patients with benign tubular adenomas.
  • [MeSH-major] Adenoma / genetics. Adenoma, Villous / genetics. Colonic Neoplasms / genetics. Gene Expression Profiling. Signal Transduction / genetics

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  • (PMID = 20514431.001).
  • [ISSN] 1791-244X
  • [Journal-full-title] International journal of molecular medicine
  • [ISO-abbreviation] Int. J. Mol. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA82450
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Wnt Proteins
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37. White V, Shaw AG, Tierney GM, Lund JN, Semeraro D: Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report. J Med Case Rep; 2008;2:130

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report.
  • Here we report a rare case of metaplastic ossification within a benign ulcerating adenoma and review the literature concerning the aetiology.
  • CONCLUSION: Heterotopic ossification in colonic adenomas is a particularly rare phenomenon, with the majority of cases occurring within malignant lesions.

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  • [Cites] Am J Pathol. 1955 Jan-Feb;31(1):73-91 [13218132.001]
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  • (PMID = 18445248.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2386133
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38. Moon CM, Cheon JH, Choi EH, Kim ES, Park JJ, Han SY, Kim DH, Kim TI, Kim WH: Advanced synchronous adenoma but not simple adenoma predicts the future development of metachronous neoplasia in patients with resected colorectal cancer. J Clin Gastroenterol; 2010 Aug;44(7):495-501
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  • [Title] Advanced synchronous adenoma but not simple adenoma predicts the future development of metachronous neoplasia in patients with resected colorectal cancer.
  • Univariate and multivariate analyses were done to identify risk factors for metachronous adenoma.
  • RESULTS: Metachronous adenomas were diagnosed in 176 patients (35.0%) and advanced adenomas in 39 (7.8%) during the follow-up period (35.7+/-20.9 mo).
  • Among the clinical and colonoscopic factors at baseline, advanced age (> or = 60 y) (odds ratio (OR)=3.64; 95% confidence intervals (CI), 1.55-8.52), the presence of advanced synchronous adenoma (OR=4.38; 95% CI, 1.77-10.85), and longer total follow-up period (OR=1.03; 95% CI, 1.01-1.04) were independently correlated with developing advanced metachronous adenoma.
  • Patients who had synchronous tubular adenoma without advanced features at baseline were not found to have an increased risk for future development of advanced metachronous adenoma compared with those in the synchronous adenoma-free group (OR=1.75; 95% CI, 0.69-4.43, P=0.650).
  • CONCLUSIONS: Our data showed that patients with advanced synchronous adenoma at baseline were identified to have an increased risk of advanced metachronous neoplasia during a longer follow-up period but those with tubular adenoma without advanced features at baseline were not.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Neoplasms, Second Primary / epidemiology

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  • (PMID = 20351568.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. M Bustamante-Balén, Bernet L, Cano R, Morell L, López A: Assessing the reproducibility of the microscopic diagnosis of sessile serrated adenoma of the colon. Rev Esp Enferm Dig; 2009 Apr;101(4):258-64
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  • [Title] Assessing the reproducibility of the microscopic diagnosis of sessile serrated adenoma of the colon.
  • INTRODUCTION: sessile serrated adenoma (SSA) is a recently described lesion that may be related to the development of up to 15% of colorectal cancers (CRCs).
  • MATERIAL AND METHODS: concordance between two pathologists in the diagnosis of serrated lesions of the colon was studied for 195 lesions (187 hyperplastic polyps and 7 serrated adenomas).
  • Possible diagnoses were: SSA, traditional serrated adenoma (TSA), hyperplastic polyp (HP), serrated polyp, tubular adenoma, or mixed lesions.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology

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  • (PMID = 19492901.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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40. Nonogaki K, Hirooka Y, Itoh A, Kawashima H, Hara K, Uchida H, Kasugai T, Ohno E, Ohmiya N, Niwa Y, Goto H: [A case of gallbladder adenoma with wide base]. Nihon Shokakibyo Gakkai Zasshi; 2008 Jan;105(1):74-80
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  • [Title] [A case of gallbladder adenoma with wide base].
  • A 65-year-old man was referred for a gallbladder elevated lesion.
  • Cholecystectomy was performed and the tumor was diagnosed as tubular adenoma of the gallbladder.
  • A gallbladder adenoma with wide base is rare, here we report this case with the several considerations.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 18176045.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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41. Guan JT, Wang L, Wang Y, Li Y, Wang R, Zhang WY, Zhan L, Zhou ZG: [Expression of AIF and caspase-3 in colorectal carcinoma, adenoma, and normal mucosa and its correlation]. Zhonghua Wei Chang Wai Ke Za Zhi; 2009 Jul;12(4):391-4
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  • [Title] [Expression of AIF and caspase-3 in colorectal carcinoma, adenoma, and normal mucosa and its correlation].
  • OBJECTIVE: To investigate the expression differences of apoptosis-inducing factor (AIF) and caspase-3 among colorectal carcinoma, adenoma and normal mucosa, and to identify the relationship between AIF and caspase-3 expression in colorectal adenoma-carcinoma sequence.
  • METHODS: Formalin-fixed paraffin embedded colorectal tissues from 174 cases, including 84 adenomas, 72 carcinomas, and 18 normal mucosa, were examined for expression of AIF and caspase-3 by streptavidin-peroxidase (SP) immunohistochemistry.
  • RESULTS: The positive rates of AIF and caspase-3 in colorectal adenoma were higher than those in normal mucosa (P <0.05).
  • The positive rate of AIF in adenoma showed no significant difference compared to colorectal carcinoma (P >0.05).
  • However, caspase-3 expression in adenomas was significantly higher than that in carcinoma (P <0.05).
  • The positive rate of AIF in tubular adenoma was significantly higher than that in villous adenoma (P <0.05), while the positive expression rate of caspase-3 in the two types of adenoma showed no significant difference (P >0.05).
  • [MeSH-major] Adenoma / metabolism. Apoptosis Inducing Factor / metabolism. Caspase 3 / metabolism. Colorectal Neoplasms / metabolism. Intestinal Mucosa / metabolism

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  • (PMID = 19598027.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Apoptosis Inducing Factor; EC 3.4.22.- / Caspase 3
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42. Lee EJ, Park CK, Kim JW, Chang DK, Kim KM: Deletion mutation of BRAF in a serrated adenoma from a patient with familial adenomatous polyposis. APMIS; 2007 Aug;115(8):982-6
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  • [Title] Deletion mutation of BRAF in a serrated adenoma from a patient with familial adenomatous polyposis.
  • BRAF gene mutations in the colorectum have been associated with serrated adenomas and less frequently with hyperplastic polyps, villous adenomas, tubular adenomas, and carcinomas.
  • We report a case with a very rare deletion mutation of BRAF (c.1799-1801delTGA, p.Val600_Lys601delinsGlu) in a serrated adenoma; the patient has familial adenomatous polyposis with a germline mutation of the APC gene (c.3578delA, p.Gln1193ArgfsX1264).
  • Genetic studies on fundic gland polyps and tubular adenomas from the same patient failed to demonstrate BRAF mutation.

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  • (PMID = 17696956.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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43. Ross I, Shwayder T: Tubular apocrine adenoma: presentation in the vaginal introitus of an eight-year-old. Pediatr Dermatol; 2010 Mar-Apr;27(2):200-1
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  • [Title] Tubular apocrine adenoma: presentation in the vaginal introitus of an eight-year-old.
  • Tubular apocrine adenoma is a very rare hamartomatous lesion that to our knowledge has never been described in the anogenital region in the pediatric population.
  • A brief report of a tubular apocrine adenoma in the vaginal introitus of an 8-year-old.
  • [MeSH-major] Adenoma / diagnosis. Vaginal Neoplasms / diagnosis

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  • (PMID = 20537077.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Kwon HJ, Kim JH, Bae JM, Cho NY, Kim TY, Kang GH: DNA methylation changes in ex-adenoma carcinoma of the large intestine. Virchows Arch; 2010 Oct;457(4):433-41
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  • [Title] DNA methylation changes in ex-adenoma carcinoma of the large intestine.
  • Ex-adenoma carcinoma (EAC) is a carcinoma with contiguous adenoma element in its vicinity which provides a morphological evidence for adenoma-carcinoma sequence.
  • Twenty-two cases of cancers had contiguous tubulovillous adenomas and 17 cases had contiguous tubular adenomas.
  • Regardless of CIMP markers or nonrelated markers, a significant increase in the number of methylated genes was found from normal mucosa to adenoma, whereas no increase was found from adenoma to carcinoma.
  • Both ALU and LINE-1 showed a significant decrease of methylation levels from normal mucosa to adenoma (p < 0.05), but there is no difference between adenoma and cancer.
  • However, SAT2 methylation level exhibited a stepwise decrease from normal mucosa to adenoma to cancer.
  • Our findings suggest that morphological progression from traditional adenoma to carcinoma does not appear to be accompanied by increases in promoter CpG island hypermethylation or repetitive DNA hypomethylation, except for SAT2 hypomethylation which showed continuous progression during multistep carcinogenesis.
  • [MeSH-major] Adenoma / genetics. Carcinoma / genetics. Colorectal Neoplasms / genetics. CpG Islands. DNA Methylation

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  • (PMID = 20711609.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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45. Lee S, Bang S, Song K, Lee I: Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon. Oncol Rep; 2006 Oct;16(4):747-54
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  • [Title] Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon.
  • The majority of colon cancers develop from pre-existing adenomas.
  • We analyzed the expression profiles in the sequence of normal colon crypts, adenomas and early-stage carcinomas using microdissected cells from tubular adenomas with foci of malignant transformation.
  • Differentially expressed genes were detected between normal-adenoma and adenoma-carcinoma, and were grouped according to the patterns of expression changes in the sequence.
  • TGF-beta2 and matrix metalloproteinase 23B were up-regulated in carcinoma but not in adenoma, supporting the pathobiological roles in malignant transformation.
  • Differentially expressed genes partly coincided with those in the adenoma-carcinoma sequence of the stomach, which was published previously, suggesting a partial overlap between the adenoma-carcinoma sequences of the colon and stomach.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Colonic Neoplasms / metabolism. Gene Expression Regulation. Gene Expression Regulation, Neoplastic

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  • (PMID = 16969489.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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46. Lee CK, Jang KT, Cho YS: Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. J Laryngol Otol; 2005 Dec;119(12):1004-6
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  • [Title] Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal.
  • Tubular apocrine adenoma (TAA) is a very rare sweat gland tumour.
  • [MeSH-major] Adenoma / pathology. Ear Canal / pathology. Ear Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16354370.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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47. Kim MS, Lee JH, Lee WM, Son SJ: A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. Ann Dermatol; 2010 Aug;22(3):319-22
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  • [Title] A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus.
  • Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor.

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  • (PMID = 20711270.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917687
  • [Keywords] NOTNLM ; Nevus sebaceus / Syringocystadenoma papilliferum / Tubular apocrine adenoma
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48. Uner A, Ebinc FA, Akyurek N, Unsal D, Mentes BB, Dursun A: Vascular endothelial growth factor, c-erbB-2 and c-erbB-3 expression in colorectal adenoma and adenocarcinoma. Exp Oncol; 2005 Sep;27(3):225-8
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  • [Title] Vascular endothelial growth factor, c-erbB-2 and c-erbB-3 expression in colorectal adenoma and adenocarcinoma.
  • METHODS: Sections of adenoma, intramucosal carcinoma and adenocarcinoma were evaluated by immunohistochemistry in 85 malignant and 37 benign colorectal neoplasms for the expression of VEGF, c-erbB-2 and c-erbB-3 considering clinicopathological variables.
  • RESULTS: VEGF was detected in comparable percentages of all neoplasm types while c-erbB-2 expression was detectable more frequently in adenoma than adenocarcinoma cases (65% vs 43%).
  • Except for the correlation of c-erbB-3 expression with Dukes' staging, there was no correlation between the studied markers and grade of differentiation, Dukes' stage and localization of colorectal adenocarcinoma. c-erbB-3 expression was seen more frequently in tubular adenomas, while c-erbB-2 expression was higher in tubulovillous and villous types.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Receptor, ErbB-2 / biosynthesis. Receptor, ErbB-3 / biosynthesis. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 16244586.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptor, ErbB-3
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49. Yoo TW, Park DI, Kim YH, Kim HS, Kim WH, Kim TI, Kim HJ, Yang SK, Byeon JS, Lee MS, Jung IK, Chung MK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS, Song JS: Clinical significance of small colorectal adenoma less than 10 mm: the KASID study. Hepatogastroenterology; 2007 Mar;54(74):418-21
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  • [Title] Clinical significance of small colorectal adenoma less than 10 mm: the KASID study.
  • BACKGROUND/AIMS: Polypectomy is the current modality of choice to prevent benign colorectal adenoma from progressing to an invasive cancer.
  • However, in cases of small colorectal adenoma, it remains unclear as to whether polypectomy is actually an effective treatment modality.
  • We evaluated the clinical significance of polypectomy in cases of small colorectal adenomas, measuring less than 10 mm.
  • A total of 5996 colorectal adenomas were detected and divided into 5 groups according to their size (Group 1; 1-5 mm, Group 2; 6-7 mm, Group 3; 8-9 mm, Group 4; 10-19 mm, Group 5; more than 20 mm).
  • The term 'advanced adenoma' refers here to tubular adenomas with diameters of at least 10 mm, or to tubulovillous, villous, or high-grade dysplasia, irrespective of size.
  • RESULTS: As the sizes of the adenomas increased, the prevalence of advanced adenoma was also observed to increase.
  • In Groups 2 and 3, the prevalence of tubulovillous or villous adenoma were higher than was expected (5.2% and 6.6%, p < 0.001).
  • CONCLUSIONS: In cases of small colorectal adenomas, measuring between 6 and 9 mm, the prevalence of cancer was at least as high as that seen in the cases of colorectal adenomas measuring between 10 and 19 mm.
  • Therefore, small colorectal adenomas measuring between 6 and 9 mm should not be ignored, in order to decrease the prevalence of colorectal cancer.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / pathology. Adenoma, Villous / surgery. Adult. Aged. Cell Transformation, Neoplastic / pathology. Cohort Studies. Colonoscopy. Female. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Male. Middle Aged. Risk Factors

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  • (PMID = 17523287.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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50. Fromont G, Barcat L, Gaudin J, Irani J: Revisiting the immunophenotype of nephrogenic adenoma. Am J Surg Pathol; 2009 Nov;33(11):1654-8
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  • [Title] Revisiting the immunophenotype of nephrogenic adenoma.
  • Nephrogenic adenoma (NA) is a rare benign lesion of the urinary tract.
  • Although its histogenesis is still debated, several reports suggest that the lesion has a renal tubular cell origin or differentiation.
  • Because all the previous studies have used an avidin-biotin (AB) detection procedure, and because cells with tubular renal differentiation are likely to contain a high level of endogenous biotin, we investigated in NA the expression of several markers including AMACR, using both AB and biotin-free detection systems.
  • [MeSH-major] Adenoma / immunology. Immunophenotyping / methods. Urologic Neoplasms / immunology

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  • (PMID = 19730362.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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51. Terao H, Matsumoto T, Umemoto S, Onuki T, Kobayashi K, Ohgo Y, Nogcchi S, Kishi H, Tsuura Y, Nagashima Y: [Metanephric adenoma: report of two cases]. Hinyokika Kiyo; 2008 Sep;54(9):599-602
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  • [Title] [Metanephric adenoma: report of two cases].
  • We report 2 cases of metanephric adenoma a rare form of adenoma.
  • One case occurred in a 54-year-old male preoperatively diagnosed with renal cell carcinoma who underwent left partial nephrectomy for a tumor 2 cm in size.
  • Thus, the patient was diagnosed with metanephric adenoma.
  • Incidental micronodules 2 mm in size and consisting of immature tubular structures were noted in the renal cortex.
  • In immunohistochemical staining, tumor cells were positive for CD57 and WT-1, and the patient was diagnosed with metanephric adenoma.
  • Preoperative differentiation of renal cell carcinoma and nephroblastoma is difficult.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 18975573.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / WT1 Proteins
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52. Lee SH, Lee DS, You IY, Jeon WJ, Park SM, Youn SJ, Choi JW, Sung R: [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. Korean J Gastroenterol; 2010 Feb;55(2):119-26
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  • [Title] [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder].
  • BACKGROUND/AIMS: In order to determine the malignant potential of gallbladder adenoma for progression to carcinoma, we evaluated the histopathologic features of adenoma and adenoma-related lesions on cholecystectomized specimens.
  • METHODS: Among 1,847 cholecystectomized specimens, 63 specimens from 26 benign adenomas, 9 carcinomas in situ (CIS), and 28 invasive carcinomas were selected.
  • A pathologist reviewed all specimens and selected benign adenomas, CIS in the adenoma, and adenoma residue in invasive carcinomas.
  • Adenomas and adenoma-related lesions were classified according to morphology (tubular, tubulopapillary, and papillary) and the consisting epithelium (biliary, pyloric metaplasia, and intestinal metaplasia).
  • The age and the size of the benign adenomas and carcinomas in the adenoma were also compared.
  • RESULTS: Adenoma and adenoma-related lesions were found in 34 out (1.8%) of all resected gallbladder.
  • Among 9 CIS and 28 invasive carcinomas, adenoma-related lesions were detected in 7 and 1 case, respectively.
  • All eight carcinomas arising in the adenoma were well-differentiated solitary tumors.
  • The diameters of the carcinomas in the adenoma were, on average, larger than that of the benign adenomas (1.8 cm vs. 0.9 cm, p=0.01).
  • The patients with carcinomas in the adenoma were, on average, older than those with benign adenomas, although the difference was insignificant (57 years vs. 47 years, p=0.09).
  • The morphology and consisting epithelium did not differ between the benign adenomas and carcinomas in the adenoma.
  • The malignant transformation occurred in 23.5% of adenomas.
  • CONCLUSIONS: Gallbladder adenoma is a rare disease, although malignant transformation occurs frequently.
  • Adenoma is a precancerous lesion and the adenoma-carcinoma sequence is one of the gallbladder cancer carcinogenesis.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Adult. Age Factors. Aged. Carcinoma / epidemiology. Carcinoma / pathology. Carcinoma / surgery. Cell Transformation, Neoplastic. Cholecystectomy. Cystadenoma / epidemiology. Cystadenoma / pathology. Cystadenoma / surgery. Female. Gallstones / complications. Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 20168058.001).
  • [ISSN] 2233-6869
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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53. Kim BS, Joo SH, Joo KR: Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report. World J Gastroenterol; 2008 Aug 7;14(29):4705-8

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  • [Title] Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report.
  • Tubulovillous adenomas are common in the colon and rectum, but are rare in the common bile duct.
  • Biliary adenomas may produce obstructive jaundice, which can be easily confused with a malignant neoplasm or stone.
  • We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice.
  • The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct.
  • The polyps were removed by endoscopic mucosal resection and shown to be tubular adenomas with high grade dysplasia.
  • Biliary adenomas require careful follow-up for early detection of recurrence and malignant transformation.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 18698689.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738799
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54. Torlakovic EE, Gomez JD, Driman DK, Parfitt JR, Wang C, Benerjee T, Snover DC: Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol; 2008 Jan;32(1):21-9
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  • [Title] Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA).
  • The morphologic distinction between various serrated polyps of the colorectum may be challenging.
  • The distinction between sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA) may be difficult using currently available criteria mostly based on cytologic characteristics.
  • TSA had low Ki-67 expression, which was limited to "ectopic crypts" and admixed tubular adenomalike areas.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Intestinal Polyps / pathology

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  • [ErratumIn] Am J Surg Pathol. 2008 Mar;32(3):491
  • (PMID = 18162766.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Ki-67 Antigen
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55. Jiao YF, Nakamura S, Sugai T, Yamada N, Habano W: Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process: new conceptual interpretation of morphogenesis. Oncology; 2008;74(3-4):127-34
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  • [Title] Serrated adenoma of the colorectum undergoes a proliferation versus differentiation process: new conceptual interpretation of morphogenesis.
  • OBJECTIVE: Serrated adenoma (SA) consists of glands both with intraluminal projection of tall columnar cells, which resemble the terminally differentiated cells in the surface epithelium, and with concave short cells, which resemble progenitor crypt cells of the colon.
  • METHODS: The expressions of both terminally differentiated markers, such as p21, cytokeratin 20 and carbonic anhydrase I, and progenitor/proliferative markers, such as beta-catenin, CD44 and Ki-67, were immunohistochemically examined in 43 SAs and 20 tubular adenomas.
  • RESULTS: P21-positive cells were more abundant in SAs than in tubular adenomas.
  • [MeSH-major] Adenoma / pathology. Adenomatous Polyps / pathology. Cell Differentiation. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18708730.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / CD44 protein, human; 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Keratin-20; 0 / Ki-67 Antigen; 0 / beta Catenin; EC 4.2.1.- / Carbonic Anhydrase I
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56. Jin Y, Sun A, Noriki S, Imamura Y, Fukuda M: Detection of cancer clones in human colorectal adenoma as revealed by increased DNA instability and other bio-markers. Eur J Histochem; 2007 Jan-Mar;51(1):1-10
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  • [Title] Detection of cancer clones in human colorectal adenoma as revealed by increased DNA instability and other bio-markers.
  • The test was applied to bioptic tissues of human colorectal polyps assessed histopathologically as hyperplastic polyp (11 cases), tubular adenoma of mild (68 cases), moderate (102 cases), and severe (46 cases) dysplasia, and adenocarcinoma (30 cases).
  • The DNA-instability test was positive in 30 (100%) adenocarcinoma cases, 46 (100%) severe dysplasia adenoma cases, 36 (35.29%) moderate dysplasia adenoma cases, and 8 (11.76%) mild dysplasia adenoma cases, indicating malignancy.
  • All other biological markers tested in the present study showed significantly higher values in those adenoma glands that were positive to the DNA-instability test, irrespective of the dysplasia grade, as compared to the markers in the adenoma glands that were negative to DNA instability testing.
  • The results indicate that cancer cell clones are already present at the adenoma stages showing positivity to DNA instability testing, enhanced proliferative activity, p53 mutation and induction of DFF45 and VEGF, at a time when the degree of morphological atypia are not yet large enough for them to be identified as cancer.
  • These factors promote cancer cell proliferation, produce heterogeneous subclones due to DNA instability, enhance their survival by escaping apoptosis, and provide abundant nutrients by neovascularization during the early-stage progression of colorectal cancer.
  • [MeSH-major] Adenoma / chemistry. Biomarkers, Tumor / analysis. Colorectal Neoplasms / chemistry. DNA, Neoplasm / analysis. Genomic Instability. Immunohistochemistry / methods

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  • (PMID = 17548263.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / caspase-activated DNase inhibitor; 5CSZ8459RP / Cytidine
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57. Nakabayashi M, Shomori K, Kiya S, Shiomi T, Nosaka K, Ito H: Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report. Yonago Acta Med; 2010 Sep;53(3):65-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report.
  • Basal cell adenoma (BCA) is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells.
  • Histopathologically, the tumor was characterized by multiple duct-like structures and tubular-trabecular masses composed of small isomorphic cells with hyperchromatic, round nuclei and an eosinophilic cytoplasm.
  • By immunohistochemistry, tumor cells of the tubular nests were positive for cytokeratin 7 and that the outer cells of tubular nests were positive for alpha smooth muscle actin (αSMA) and calponin.

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  • (PMID = 24031120.001).
  • [ISSN] 0513-5710
  • [Journal-full-title] Yonago acta medica
  • [ISO-abbreviation] Yonago Acta Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3763784
  • [Keywords] NOTNLM ; basal cell adenoma / immunohistochemistry / parotid gland
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58. Rahemtullah A, Oliva E: Nephrogenic adenoma: an update on an innocuous but troublesome entity. Adv Anat Pathol; 2006 Sep;13(5):247-55

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  • [Title] Nephrogenic adenoma: an update on an innocuous but troublesome entity.
  • Nephrogenic adenoma (NA) is a rare benign lesion of the urothelial tract that is typically preceded by some form of genitourinary insult.
  • Although generally presumed to be a metaplastic process of the urothelium, recent evidence suggests that NA may in fact be derived from detached renal tubular cells implanting along the urothelial tract in previously injured areas, at least in cases associated with a kidney transplant.
  • Recognition of its characteristic patterns, and awareness of its unusual architectural and cytologic features, is key to making the diagnosis of NA and distinguishing this lesion from malignant neoplasms occurring at the same sites, in particular, clear cell carcinoma, nested or microcystic variants of urothelial carcinoma and prostatic adenocarcinoma.
  • [MeSH-major] Adenoma / pathology. Urologic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Prostatic Neoplasms / pathology. Urothelium / pathology

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  • (PMID = 16998318.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 64
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59. Ihrler S, Schwarz S, Zengel P, Guntinas-Lichius O, Kirchner T, Weiler C: [Pleomorphic adenoma: pitfalls and clinicopathological forms of progression]. Pathologe; 2009 Nov;30(6):446-56
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  • [Title] [Pleomorphic adenoma: pitfalls and clinicopathological forms of progression].
  • In the majority of cases the diagnosis of pleomorphic adenoma (PA) is straightforward.
  • In "monomorphic" types of PA problems may result: Epithelial-rich PA need to be distinguished from basal cell adenoma or canalicular adenoma.
  • Focal biphasic-tubular differentiation with CK7/18-positive ductal cells is good evidence for a tumour within the wide spectrum of PA.
  • Focal peripheral pseudoinfiltration can represent physiological growth pattern of PA; this may render a difficult distinction from low-malignant carcinomas like adenoid-cystic or epithelial-myoepithelial carcinoma, harbouring also tubular structures.
  • The different progression steps of carcinoma ex pleomorphic adenoma (CEPA), starting with intraductal carcinoma, are highly relevant with respect to prognosis and therapy.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Reoperation. Salivary Ducts / pathology. Salivary Glands / pathology

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  • (PMID = 19844715.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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60. Yamao T, Isomoto H, Yamaguchi N, Irie J, Ito Y, Nakashima Y, Shikuwa S, Mizuta Y, Kohno S, Imamura S, Yamakawa M, Fujita F, Hayashi T: Magnified endoscopic observation using narrow-band imaging of periampullary adenoma in a patient with familial adenomatous polyposis. Med Sci Monit; 2009 Dec;15(12):CS169-73
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  • [Title] Magnified endoscopic observation using narrow-band imaging of periampullary adenoma in a patient with familial adenomatous polyposis.
  • BACKGROUND: Adenoma of the major papilla carries a relatively high risk of malignant transformation to carcinoma, the leading cause of death in patients with familiar adenomatous polyposis (FAP) after colectomy.
  • Histopathological examination of the removed specimen showed tubular adenoma without malignant foci.
  • CONCLUSIONS: Thus, endoscopic surveillance and removal of ampullary adenomas appear to be justified.
  • [MeSH-major] Adenoma / diagnosis. Adenomatous Polyposis Coli / diagnosis. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Duodenoscopy / methods

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  • (PMID = 19946237.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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61. Araújo VC, Furuse C, Cury PR, Altemani A, Alves VA, de Araújo NS: Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma. Appl Immunohistochem Mol Morphol; 2008 Jan;16(1):48-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma.
  • This study was conducted to analyze the participation of tenascin and fibronectin, components of the extracellular matrix, in different types of carcinoma ex pleomorphic adenoma (CXPA).
  • In reminiscent pleomorphic adenoma, tenascin and fibronectin were observed around tubular structures and in the stroma.
  • In areas of in situ carcinoma of the intracapsular type, the expression of these extracellular matrix proteins was enhanced compared with areas of residual pleomorphic adenoma.

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  • (PMID = 18091320.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibronectins; 0 / Tenascin
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62. Yang GZ, Li J, Ding HY: [Nipple adenoma: report of 18 cases with review of literatures]. Zhonghua Bing Li Xue Za Zhi; 2009 Sep;38(9):614-6
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  • [Title] [Nipple adenoma: report of 18 cases with review of literatures].
  • OBJECTIVE: To investigate the clinicopathological and immunohistochemical features, diagnosis and differential diagnosis of nipple adenoma of the breast.
  • METHODS: Morphological observation and immunohistochemistry were applied to 18 cases of nipple adenoma with a review of the related literatures.
  • RESULTS: The neoplasms were localized at nipples or under the areola of breast, adherent to the epidermis, mainly composed of dilated ducts in a tubular appearance associated with fibrotic matrix.
  • The glandular epithelium showed various type of proliferation, forming thick layers or complex structures such as papillae, micropapillae, tufts, fronds, arcades or bridges accompanying with solid or cribriform cell nests.
  • CONCLUSIONS: Nipple adenoma is an infrequent type of benign breast neoplasm, presenting as sclerosing papilloma, papillomatosis or florid sclerosing adenosis.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Nipples / pathology

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  • (PMID = 20079190.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CK-34 beta E12; 0 / Keratin-5; 68238-35-7 / Keratins
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63. Kuwabara H, Haginomori S, Takamaki A, Ito K, Takenaka H, Kurisu Y, Tsuji M, Mori H: Lipomatous pleomorphic adenoma of the ceruminous gland. Pathol Int; 2006 Jan;56(1):51-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous pleomorphic adenoma of the ceruminous gland.
  • A case of lipomatous pleomorphic adenoma in the ceruminous gland is reported.
  • Light microscopic examination revealed a well-circumscribed tumor composed of tubular structures with apocrine secretion and ceroid deposition, extensive mature adipocytes, and spindle-shaped myoepithelial cells in the myxoid and fibrous stroma.
  • This case demonstrates the peculiar location of a lipomatous pleomorphic adenoma in the external auditory canal.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Ear Canal. Ear Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16398681.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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64. Herlitz LC, Tong GX, Hamele-Bena D, Greenebaum E: Nephrogenic adenoma identified on urine cytology using PAX-2 immunostaining. Diagn Cytopathol; 2008 Jan;36(1):47-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nephrogenic adenoma identified on urine cytology using PAX-2 immunostaining.
  • However, the cytologic features of nonneoplastic lesions of the lower urinary tract, including nephrogenic adenoma, are nonspecific and may cause false positive diagnosis.
  • Recent evidence has demonstrated that nephrogenic adenoma is a true "nephrogenic" lesion derived from the exfoliated and implanted renal tubular cells in the urinary tract.
  • This has promoted the use of immunostaining of renal transcription factor PAX2 in tissue biopsies to differentiate nephrogenic adenoma from the common malignant tumors of the lower urinary tract.
  • We report here that PAX2 immunostaining can also be used in urine cytology specimen to identify nephrogenic adenoma.
  • Combination of PAX2 immunostaining and cytologic analysis may increase the accuracy in identifying this benign lesion in urine cytology specimen and therefore reduce unnecessary repeat cystoscopy and biopsy procedures.
  • This may be a cost effective follow- up method for patients with an established diagnosis of nephrogenic adenoma.
  • [MeSH-major] Adenoma / diagnosis. PAX2 Transcription Factor / metabolism. Urinary Bladder Neoplasms / diagnosis. Urine / cytology

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  • (PMID = 18064687.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human
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65. Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D: Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. Acta Dermatovenerol Croat; 2007;15(3):148-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.
  • A case of a 79-year-old woman with axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia is presented.
  • In one area, the tumor was lobular and composed of tubular structures lined with one layer of uniform cuboidal or columnar eosinophilic cells, indicating a pre-existing apocrine adenoma.
  • This and previously reported cases suggest that apocrine hyperplasia and apocrine adenoma may represent successive steps in the development of apocrine carcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17868540.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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66. Terada T: Intraductal tubular carcinoma, intestinal type, of the pancreas. Pathol Int; 2009 Jan;59(1):53-8
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  • [Title] Intraductal tubular carcinoma, intestinal type, of the pancreas.
  • Presented herein is an unusual case of intraductal tubular carcinoma, intestinal type, of the pancreas.
  • This tumor was characterized by intraductal adenoma with a few malignant foci, and also by entire involvement of the main pancreatic duct and no involvement of its branches.
  • Because a biopsy showed tubular atypical cells, pancreato-duodenectomy was performed.
  • Microscopically, the entire main pancreatic duct had proliferation of tubular adenomatous tumor without secretory mucins.
  • On mucin histochemistry the tumor cell cytoplasm contained a little or no neutral and acidic mucus, and no secretory mucins were recognized.
  • In summary, presented here is an extremely rare case of intraductal tubular carcinoma, intestinal type, showing focal malignant foci.


67. Kummerfeld M, Knieriem A, Wohlsein P: [Osteomyelitis and papillary renal adenoma in a red panda (Ailurus fulgens fulgens)]. Dtsch Tierarztl Wochenschr; 2008 Nov;115(11):421-5
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  • [Title] [Osteomyelitis and papillary renal adenoma in a red panda (Ailurus fulgens fulgens)].
  • Additionally, in the kidney a papillary renal adenoma was found.
  • Immunohistochemistry revealed an expression of cytokeratins 8 and/or 19 indicating an origin from the renal tubular epithelium.
  • [MeSH-major] Carcinoma, Renal Cell / veterinary. Kidney Neoplasms / veterinary. Osteomyelitis / veterinary. Ursidae

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  • (PMID = 19024549.001).
  • [ISSN] 0341-6593
  • [Journal-full-title] DTW. Deutsche tierärztliche Wochenschrift
  • [ISO-abbreviation] DTW. Dtsch. Tierarztl. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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68. Cashell AW: Apocrine adenoma of the breast. W V Med J; 2008 Mar-Apr;104(2):16-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine adenoma of the breast.
  • A case of apocrine adenoma, a rare benign tumor of the breast is reported.
  • Apocrine adenomas have been reported arising in a variety of sites including the breast, (1-5) perianal region, (6,7) eyelid, (8) and axilla. (9) Their appearance has similarities to the apocrine metaplasia commonly seen in fibrocystic change of the breast but they are well-circumscribed tumors with closely packed tubular and papillary structures.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Apocrine Glands / pathology. Breast Neoplasms / diagnosis

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  • (PMID = 18491794.001).
  • [ISSN] 0043-3284
  • [Journal-full-title] The West Virginia medical journal
  • [ISO-abbreviation] W V Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Tong GX, Melamed J, Mansukhani M, Memeo L, Hernandez O, Deng FM, Chiriboga L, Waisman J: PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol; 2006 Mar;19(3):356-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] PAX2: a reliable marker for nephrogenic adenoma.
  • Nephrogenic adenoma is a rare lesion of the urinary tract.
  • It recently was demonstrated that nephrogenic adenoma in renal transplant patients originated from the renal tubular epithelium.
  • This newly proved, but long sought information may be helpful in the differential diagnosis of nephrogenic adenoma.
  • In this study, we investigated the expression of a renal transcription factor, PAX2, in 39 nonrenal transplant-related nephrogenic adenomas, 100 adenocarcinomas of the prostate gland, and 47 urothelial carcinomas of the urinary tract.
  • A strong and distinct nuclear staining of PAX2 was found in all 39 cases of nephrogenic adenoma (100%), but not in normal prostate tissue, normal urothelium, adenocarcinomas of the prostate gland, and invasive urothelial carcinomas.
  • Focal CD10 was detected in six of 13 nephrogenic adenomas in the superficial papillary component and in normal prostate epithelium, normal urothelium, lymphocytes, adenocarcinoma of the prostate gland, and urothelial carcinoma.
  • There was no uroplakins detected in nephrogenic adenoma.
  • Therefore, these findings are suggesting that nephrogenic adenoma in nonrenal transplant patients may also arise from the renal epithelium, as did the comparable lesions after transplantation.
  • PAX2 is a specific and sensitive immunohistochemical marker in identification and differential diagnosis of nephrogenic adenoma.
  • [MeSH-major] Adenoma / pathology. Biomarkers, Tumor / analysis. PAX2 Transcription Factor / analysis. Urologic Neoplasms / pathology

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  • (PMID = 16400326.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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70. Lee SY, Han HS, Lee KY, Hwang TS, Kim JH, Sung IK, Park HS, Jin CJ, Choi KW: Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncol Rep; 2007 May;17(5):1051-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonic hedgehog expression in gastric cancer and gastric adenoma.
  • From August 2005 to May 2006, 52 gastric cancers and 16 gastric adenomas were obtained from surgically or endoscopically resected specimens.
  • According to Lauren's classification, Shh expression was stronger in the intestinal type than in the diffuse type (p<0.001).
  • Although Shh expression was not related to the location, size, metastatic status, or mucin phenotype of the gastric cancer, the expression was stronger in the tubular type of gastric cancer than in the mucinous and signet-ring cell types (p=0.001).
  • Shh expression was stronger in gastric adenoma than in the diffuse-type gastric cancer (p<0.001), but revealed no difference with that of the intestinal-type gastric cancer (p=0.30).
  • The stronger Shh expression in intestinal metaplasia and gastric adenoma indicates that hedgehog protein is involved at an early phase of gastric carcinogenesis.
  • [MeSH-major] Adenoma / metabolism. Hedgehog Proteins / biosynthesis. Stomach Neoplasms / metabolism

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  • (PMID = 17390043.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / SHH protein, human
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71. Nakamura M, Shibata T, Tahara T, Yoshioka D, Okubo M, Mizoguchi Y, Kuroda M, Arisawa T, Hirata I: The usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions in the stomach diagnosed as adenoma by using biopsy samples. Gastrointest Endosc; 2010 May;71(6):1070-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions in the stomach diagnosed as adenoma by using biopsy samples.
  • BACKGROUND: Therapeutic strategies for flat elevated (0-IIa) lesions in the stomach diagnosed as adenoma by biopsy are currently not established, because some difficulties have previously been reported in the evaluation of vascular patterns alone for the differential diagnosis between adenoma and carcinoma.
  • OBJECTIVE: We attempted to evaluate the 0-IIa lesions diagnosed as adenoma by using magnifying endoscopy with narrow-band imaging (MENBI) to distinguish them as either adenoma or carcinoma.
  • PATIENTS: Fourteen adenomatous lesions (6 adenomas and 8 carcinomas confirmed postoperatively) diagnosed with preoperative biopsies from patients who had undergone endoscopic submucosal dissection were evaluated.
  • MAIN OUTCOME MEASUREMENTS: The rate of SSs and IMVPs in adenoma and carcinoma.
  • RESULTS: Significant SSs were tubular in the adenoma and unclear in the carcinoma.
  • Regarding IMVP subcategories, (1) slight intrastructual irregular microvascular patterns (ISIMVPs) accounted for 97%, (2) severe ISIMVPs accounted for 0%, (3) fine networks accounted for 3%, and (4) corkscrews accounted for 0% of cases in the adenomas.
  • CONCLUSIONS: Our combined evaluation method using MENBI offers the ability to establish proper therapeutic strategies for lesions that are difficult to identify as adenoma or carcinoma.
  • [MeSH-major] Adenoma / diagnosis. Gastroscopy / methods. Stomach / pathology. Stomach Neoplasms / diagnosis

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  • [Copyright] 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20438898.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Vieth M, Vogel C, Kushima R, Borchard F, Stolte M: Pyloric gland adenoma-- how to diagnose? Cesk Patol; 2006 Jan;42(1):4-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pyloric gland adenoma-- how to diagnose?
  • The term "pyloric gland adenoma" reflects its etiogenesis from deep mucoid glands in the stomach.
  • Typically, pyloric gland adenomas are strongly positive for Mucin 6 (deep mucoid gastric glands).
  • Combination or transdifferentiation with ordinary tubular (intestinal differentiation) adenoma can be observed.
  • The frequency of pyloric gland adenoma is given in the literature being 2.7% of all gastric polyps.
  • Therefore pyloric gland adenomas are not that rare that one might assume.
  • Pyloric gland adenomas can arise in gastric heterotopia and gastric metaplasia in the whole gastrointestinal tract.
  • [MeSH-major] Adenoma / diagnosis. Gastric Mucosa. Stomach Neoplasms / diagnosis

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  • (PMID = 16506593.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 24
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73. Ishida M, Hotta M, Kushima R, Tsuruoka S, Ohji M, Okabe H: Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Rinsho Byori; 2009 Aug;57(8):746-51
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  • [Title] Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • Ductal adenocarcinoma of the lacrimal gland is extremely rare; to our knowledge, only seven de novo cases and one case of ductal adenocarcinoma ex pleomorphic adenoma have been reported in the literature.
  • Here, we report a case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • A 70-year-old Japanese female received the resection of the recurrent lacrimal gland tumor (second surgery), under the clinical diagnosis of recurrent pleomorphic adenoma, fifteen years after the initial surgical resection.
  • The resected tumor was composed of recurrent pleomorphic adenoma and adenocarcinoma.
  • Adenocarcinoma component showed infiltrative papillo-tubular or microcystic growth of carcinoma cells, which had pleomorphic large nuclei with prominent nucleoli and rich eosinophilic cytoplasm.
  • Accordingly, the diagnosis of ductal adenocarcinoma ex pleomorphic adenoma was made.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Carcinoma, Ductal, Breast / diagnosis. Carcinoma, Ductal, Breast / pathology. Eye Neoplasms / diagnosis. Eye Neoplasms / pathology. Lacrimal Apparatus. Neoplasms, Multiple Primary

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  • (PMID = 19764409.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 13
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74. Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R: Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology; 2009;41(4):372-8
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  • [Title] Mammary-like gland adenoma of the vulva: review of 46 cases.
  • AIMS: Hidradenoma papilliferum (HP) of the anogenital region, which was previously thought to be an apocrine tumour, is now believed to be derived from anogenital mammary-like glands (MLG) and is more accurately termed MLG adenoma.
  • Tubular, papillary, cystic and solid areas were seen in various combinations.
  • Two cell types, epithelial and myoepithelial, were present.
  • The most common epithelial cell, the ductal cell, was seen alone in 43% or associated with apocrine metaplasia (57%) and/or foam cells (13%) and/or squamous cells (13%).
  • Myoepithelial cells were usually flattened, but were prominent and clear cell in type in 11%.
  • Unusual architectural patterns resembled breast lesions such as erosive adenomatosis, sclerosing adenosis and ductal adenoma.
  • CONCLUSIONS: MLG adenomas demonstrate a marked diversity in histological pattern and cell morphology.
  • The ductal cell and a site compatible with and/or the presence of adjacent normal MLG are the most characteristic features.
  • Unusual vulvar tumours, which have been previously reported as erosive adenomatosis, sclerosing adenosis, papillary adenofibroma, syringocystadenoma papilliferans, etc., are variants of MLG adenomas.
  • [MeSH-major] Adenoma / pathology. Mammary Glands, Human / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19404851.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 46
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75. Pacchioni D, Volante M, Casetta G, Sapino A, Marchiò C, Bussolati G: Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case. Am J Surg Pathol; 2007 Apr;31(4):632-6
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  • [Title] Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case.
  • We herein report an unusual case of a low-grade myxoid renal epithelial neoplasm, with peculiar and previously unreported morphologic and immunohistochemical features.
  • The lesion was characterized by noninfiltrative borders, myxoid stroma and elongated tubular and cordlike epithelial structures.
  • These were lined by 2 different epithelial cell types, flat and elongated basal cells and cuboidal to spindle shaped eosinophilic luminal cells, with low-grade nuclear features and a few small nucleoli.
  • The lesion morphologically resembled a pleomorphic adenoma of the salivary gland.
  • The tumor proved benign at follow-up.
  • A definitive classification and histogenetic interpretation of this previously unreported tumor type awaits description of further cases showing similar features which, perhaps, as it may happen, went so far unnoticed.
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Salivary Gland Neoplasms / pathology

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  • (PMID = 17414112.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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76. Sokolova IA, Matsko DE, Hes O, Michal M: [Mucinous tubular and spindle-cell carcinoma of the kidney]. Arkh Patol; 2006 Jul-Aug;68(4):14-5
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  • [Title] [Mucinous tubular and spindle-cell carcinoma of the kidney].
  • 4 cases (2 males and 2 females) of mucinous tubular and spindle-cell carcinoma of the kidney were studied.
  • Microscopically, this tumor comprised two major cell populations.
  • Only one tumor had both cell components.
  • Mucinous tubular and spindle-cell carcinoma of the kidney should be differentiated from angiomyolipoma with the preponderance of a leiomyomatous component, renal smooth muscle neoplasms, metanephrotic adenoma, and renal cell carcinoma with sarcomatoid differentiation.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 16986488.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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77. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ: Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study. Carcinogenesis; 2007 Jul;28(7):1510-9
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  • [Title] Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
  • Dietary folate and alcohol consumption as well as polymorphic variants in one-carbon metabolism genes may modulate risk of colorectal adenoma through aberrant DNA methylation and altered nucleotide synthesis and repair.
  • We assessed the association of 24 non-synonymous single nucleotide polymorphisms (nsSNPs) in 13 genes in the one-carbon metabolism pathway and risk of colorectal adenoma in 556 incident cases and 557 controls nested in the Nurses' Health Study.
  • Most of the SNPs were not associated with risk of colorectal adenoma.
  • We did, however, observe a modest increased risk among carriers of the transcobalamin (TCN) II 259 Pro/Arg + Arg/Arg variant (odds ratio 1.48, 95% confidence interval 1.09-2.02) for colorectal adenoma.
  • In addition, the methionine synthase reductase (MTRR) Arg415Cys and MTRR Ser284Thr variant carriers, also in the vitamin B(12) pathway, have suggestive associations with advanced colorectal adenoma (defined as being larger than 1 cm, villous, tubular-villous or carcinoma in situ histology).
  • We observed significant evidence for departure from multiplicative interaction for the betaine-homocysteine methyltransferase (BHMT) Arg239Gln with dietary methyl status (based on intake of dietary folate, methionine and alcohol intake) in relation to colorectal adenoma; no such interaction was observed for the other 23 SNPs.
  • Further investigation is required to validate the association of the polymorphisms in the one-carbon metabolic genes and risk of colorectal adenoma.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Genetics, Population. One-Carbon Group Transferases / genetics. Polymorphism, Single Nucleotide

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  • (PMID = 17389618.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA87969; United States / NCI NIH HHS / CA / P01-CA087969; United States / NCI NIH HHS / CA / T-32 CA 09001-30; United States / NCI NIH HHS / CA / U54 CA100971
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Transcobalamins; 935E97BOY8 / Folic Acid; AE28F7PNPL / Methionine; EC 1.18.1.- / methionine synthase reductase; EC 1.18.1.2 / Ferredoxin-NADP Reductase; EC 2.1.- / One-Carbon Group Transferases; EC 2.1.1.5 / BHMT protein, human; EC 2.1.1.5 / Betaine-Homocysteine S-Methyltransferase; P6YC3EG204 / Vitamin B 12
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78. Muthukrishnan J, Hari Kumar KV, Jha R, Jha S, Modi KD: Distal renal tubular acidosis due to primary hyperparathyroidism. Endocr Pract; 2008 Dec;14(9):1133-6
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  • [Title] Distal renal tubular acidosis due to primary hyperparathyroidism.
  • OBJECTIVE: To present 4 cases of distal renal tubular acidosis (RTA) in patients with primary hyperparathyroidism (PHPT) and discuss their possible etiopathogenetic correlation.
  • Complete resolution of distal RTA was documented after surgical cure of PHPT by removal of a parathyroid adenoma.
  • CONCLUSION: Hypercalciuria in PHPT can lead to nephrocalcinosis and renal tubular dysfunction, which manifests as distal RTA.
  • [MeSH-major] Acidosis, Renal Tubular / etiology. Hyperparathyroidism, Primary / complications
  • [MeSH-minor] Adolescent. Adult. Bone Diseases / diagnosis. Bone Diseases / etiology. Female. Humans. Male. Middle Aged. Muscular Diseases / diagnosis. Muscular Diseases / etiology. Young Adult

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  • (PMID = 19158053.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Soreide K, Buter TC, Janssen EA, van Diermen B, Baak JP: A monotonous population of elongated cells (MPECs) in colorectal adenoma indicates a high risk of metachronous cancer. Am J Surg Pathol; 2006 Sep;30(9):1120-9
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  • [Title] A monotonous population of elongated cells (MPECs) in colorectal adenoma indicates a high risk of metachronous cancer.
  • We evaluated the prognostic value of classical clinicopathologic features and a monotonous population of elongated cells (MPECs) in colorectal adenomas from 171 consecutively selected population-based patients with long-term follow-up.
  • Ten of 171 adenomas (5.8%) developed metachronous CRC (defined as >24 mo interval and >5 cm from the index adenoma to the cancer).
  • Median follow-up of adenomas with metachronous CRC was 68.4 and without cancer 149.7 months (range: 25 to 192 and 25 to 256, respectively).
  • The most prognostic classical features were the localization of the marker adenoma as proximal (ie, in the cecum through transverse colon) versus distal from the transverse colon [P=0.0003, hazard ratio (HR)=8] and the number of polyps found during colonoscopy (<or=2 vs.>2, P=0.002, HR=6).
  • Of the 171 adenomas, 50 (29%) had MPECs, of which 9 (18%) patients developed metachronous CRC at follow-up, contrasting 1/121 (0.8%) without MPECs (P=0.0003, HR=23).
  • MPECs occurred in both low-grade and high-grade dysplasia, and in tubular and (tubulo) villous adenomas.
  • Adenomas proximally located had additional value but only if they were MPEC positive (which only occurred in 5 adenomas, 3 of which (60%) developed cancer).
  • Having more than 2 polyps also had additional prognostic value but only in MPEC-negative adenomas [10 cases; 1 (10%) developed cancer].
  • Thus, colorectal adenomas with subsequent metachronous cancer development can be identified more accurately with MPECs than with classical prognostic factors.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 16931957.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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80. Ohike N, Kim GE, Tajiri T, Krasinskas A, Basturk O, Coban I, Bandyopadhyay S, Morohoshi T, Goodman M, Kooby DA, Sarmiento JM, Adsay NV: Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases. Am J Surg Pathol; 2010 Dec;34(12):1731-48
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  • [Title] Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases.
  • Here, we provide a detailed analysis of these neoplasms, which we propose to refer to as intra-ampullary papillary-tubular neoplasm (IAPN).
  • (1) Clinical: The mean age was 64 years, male/female ratio was 2.4, and mean tumor size was 2.7 cm. (2) Pathology: The tumors had a mixture of both papillary and tubular growth (each constituting at least 25% of the lesion) in 57%; predominantly (>75%) papillary in 23%, and predominantly (>75%) tubular in 20%.
  • In terms of cell-lineage morphology, 45% had a mixture of patterns.
  • However, when evaluated with a forced-binary approach as intestinal (INT) versus gastric/pancreatobiliary (GPB) based on the predominant pattern, 74% were classified as INT and 26% as GPB. (3) Immunohistochemistry: Percent sensitivity/specificity of cell-lineage markers were, for INT phenotype: MUC2 85/78 and CDX2 94/61; and for GBP: MUC1 89/79, MUC5AC 95/69, and MUC6 83/76, respectively.
  • Cell lineage in the invasive component was the same as that of the preinvasive component in 84%.
  • CONCLUSIONS: Tumoral intraepithelial neoplasia occurring within the ampulla are highly analogous to pancreatic or biliary intraductal papillary and tubular neoplasms as evidenced by their papillary and/or tubular growth, variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence), and thus we propose to refer to these as IAPN.

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  • (PMID = 21084962.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P20 CA101936; United States / NCI NIH HHS / CA / P50 CA062924; United States / NCI NIH HHS / CA / P50 CA062924-18; United States / NCI NIH HHS / CA / CA101936
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS315774; NLM/ PMC3168573
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81. Lee DK, Chung KW, Baek CH, Jeong HS, Ko YH, Son YI: Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):884-8
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  • [Title] Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging.
  • OBJECTIVE: The goal of this study was to report the radiologic characteristics of basal cell adenoma of the parotid gland, which is a relatively rare neoplasm.
  • METHODS: A radiology and otolaryngology specialist reviewed the 2-phase helical computed tomography (CT) (n = 6) and/or magnetic resonance (MR) imaging (n = 2) scans of 7 patients with basal cell adenoma.
  • These tumors were classified as the solid subtype on histologic examination.
  • Meanwhile, the tumors with large cystic areas (n = 2) showed gradual and additional enhancement on the delayed phase and were classified as the tubular or trabecular subtype on pathologic evaluation.
  • There were small spots of low attenuation in the tumors of the solid subtype, which were proved to be intratumoral microcysts in the pathologic correlation.
  • CONCLUSIONS: Basal cell adenomas of the parotid gland present as small well-marginated tumors and appear as masses with central large cysts or solid masses with microcysts on CT and MR imaging scans.
  • Basal cell adenomas of the parotid gland had at least 2 different enhancement patterns on the 2-phase helical CT scans, and the enhancement patterns and imaging architecture were related to the histologic subtype of the tumors.
  • [MeSH-major] Adenoma / diagnosis. Magnetic Resonance Imaging / methods. Parotid Gland / pathology. Parotid Gland / radiography. Parotid Neoplasms / diagnosis. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Contrast Media / administration & dosage. Female. Humans. Image Enhancement / methods. Iopamidol. Male. Middle Aged. Rare Diseases

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  • (PMID = 16272868.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; JR13W81H44 / Iopamidol
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82. Olgac S, Hutchinson B, Tickoo SK, Reuter VE: Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma. Mod Pathol; 2006 Feb;19(2):218-24
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  • [Title] Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma.
  • Metanephric adenoma (MA), a well-described renal neoplasm, usually behaves in a benign fashion.
  • It may have areas that are morphologically similar to papillary renal cell carcinoma (RCC) type, or epithelial (tubular predominant) type Wilms' tumor.
  • [MeSH-major] Adenoma / pathology. Biomarkers, Tumor / analysis. Kidney Neoplasms / pathology. Racemases and Epimerases / analysis
  • [MeSH-minor] Antigens, CD57 / analysis. Carcinoma, Papillary / enzymology. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / enzymology. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis. WT1 Proteins / analysis. Wilms Tumor / enzymology. Wilms Tumor / pathology

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  • (PMID = 16424894.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / WT1 Proteins; 68238-35-7 / Keratins; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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83. Otake S, Takeda H, Suzuki Y, Fukui T, Watanabe S, Ishihama K, Saito T, Togashi H, Nakamura T, Matsuzawa Y, Kawata S: Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin Cancer Res; 2005 May 15;11(10):3642-6
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  • [Title] Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance.
  • To investigate whether visceral fat accumulation contributes to colorectal carcinogenesis, we examined its accumulation and the levels of the adipose tissue-derived hormone adiponectin in Japanese patients with colorectal adenoma.
  • EXPERIMENTAL DESIGN: Fifty-one consecutive Japanese patients ages >/=40 years and with colorectal adenoma were subjected to measurement of visceral fat area by computed tomography scanning and plasma adiponectin concentration.
  • RESULTS: The patients with colorectal adenoma showed significantly more visceral fat area and significantly less plasma adiponectin concentration in comparison with the controls [odds ratio (OR), 2.19; 95% confidence interval (95% CI), 1.47-3.28; P < 0.001 and OR, 0.24; 95% CI, 0.14-0.41; P < 0.001, respectively] by logistic regression analysis.
  • HOMA-IR index was also associated with colorectal adenoma (OR 2.60; 95% CI, 1.20-5.64; P = 0.040).
  • Visceral fat area and adiponectin were associated with adenoma number (1, 2, >/= 3), the size of the largest adenoma (<10 and >/=10 mm), and adenoma histology (tubular and tubulovillous/villous).
  • CONCLUSIONS: These results suggest an association of visceral fat accumulation and decreased plasma adiponectin concentration with colorectal adenoma in Japanese patients.
  • [MeSH-major] Adenoma / physiopathology. Adipose Tissue. Body Composition. Colorectal Neoplasms / physiopathology. Insulin Resistance. Intercellular Signaling Peptides and Proteins / blood

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  • (PMID = 15897559.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Intercellular Signaling Peptides and Proteins
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84. Xiao GQ, Burstein DE, Miller LK, Unger PD: Nephrogenic adenoma: immunohistochemical evaluation for its etiology and differentiation from prostatic adenocarcinoma. Arch Pathol Lab Med; 2006 Jun;130(6):805-10
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  • [Title] Nephrogenic adenoma: immunohistochemical evaluation for its etiology and differentiation from prostatic adenocarcinoma.
  • CONTEXT: Nephrogenic adenoma is a rare benign lesion of the urinary tract.
  • Owing to its strong association with a history of urinary tract irritation, nephrogenic adenoma was initially thought to originate from urothelial metaplasia; however, no solid proof of this association has been found.
  • More recent investigation has pointed to a renal tubular cause.
  • In addition to its uncertain origin, there can be diagnostic difficulty in distinguishing nephrogenic adenoma from prostatic carcinoma, particularly when dealing with lesions from the prostatic urethra.
  • OBJECTIVE: To elucidate a possible histogenic relationship between nephrogenic adenoma and renal tubules, and also to evaluate the role of immunohistochemistry in the diagnostic distinction between nephrogenic adenoma and prostate carcinoma.
  • DESIGN: Immunohistochemical studies were performed for P504S, prostate-specific antigen, CD10, p63, and epithelial membrane antigen on 9 cases of nephrogenic adenoma, 10 cases of normal renal parenchyma, and 10 cases of prostatic tissue, both benign and malignant.
  • RESULTS: Nephrogenic adenoma shares the same immunohistochemical profile as distal renal tubules: both are positive for P504S and epithelial membrane antigen and negative for p63, CD10, and prostate-specific antigen.
  • CONCLUSION: These findings provide supporting evidence that nephrogenic adenoma is derived from distal renal tubules.
  • Our results also demonstrated that the combination of P504S and prostate-specific antigen with epithelial membrane antigen is a valuable tool in distinguishing prostatic carcinoma from nephrogenic adenoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Immunohistochemistry / methods. Prostatic Neoplasms / diagnosis. Urologic Neoplasms / diagnosis

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  • (PMID = 16740031.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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85. Oo KZ, Xiao PQ: Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review. Arch Pathol Lab Med; 2009 Sep;133(9):1487-9
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  • [Title] Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review.
  • Infiltrating syringomatous adenoma of the nipple is a rare neoplasm of the breast.
  • Syringomatous adenoma of the nipple is often misdiagnosed because clinical examination and mammographic findings of syringomatous adenoma of the nipple mimic carcinoma.
  • Despite its benign behavior, syringomatous adenoma of the nipple usually shows infiltrative expansile proliferation into adjacent tissue and underlying breast tissue.
  • Histologically and clinically, syringomatous adenoma of the nipple is often confused with tubular carcinoma as well as low-grade adenosquamous carcinoma of the breast.

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  • (PMID = 19722761.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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86. Nusko G, Hahn EG, Mansmann U: Risk of advanced metachronous colorectal adenoma during long-term follow-up. Int J Colorectal Dis; 2008 Nov;23(11):1065-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk of advanced metachronous colorectal adenoma during long-term follow-up.
  • BACKGROUND: According to the adenoma-carcinoma concept, all colorectal adenomas are to be removed and all patients have to undergo regular surveillance examinations.
  • Statistical analysis using chi (2)-testing of adenoma characteristics found in four subsequent recurrence periods and calculation of the relative risk (RR) for the development of metachronous adenomas of advanced pathology was performed.
  • RESULTS: In comparison with the initial findings, metachronous adenomas are, in general, significantly smaller ones (p < 0.00001), more frequently tubular lesions (p < 0.00001) and bearing less often high-grade dysplasia (p < 0.00001).
  • Adenomas of advanced pathology were significantly less often found during follow-up than at baseline examination (p < 0.0001).
  • These differences are found between the initial and four subsequent generations of metachronous adenomas.
  • Patients with adenomas of advanced pathology at baseline have a significantly higher risk for metachronous adenomas of advanced pathology (RR 1.51; 95%CI 1.04-1.93) at the first recurrence.
  • CONCLUSIONS: Metachronous adenomas show uniform characteristics of being small tubular lesions rarely bearing high-grade dysplasia.
  • [MeSH-major] Adenoma / etiology. Colonic Polyps / surgery. Colorectal Neoplasms / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 18597098.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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87. Nusko G, Hahn EG, Mansmann U: Characteristics of metachronous colorectal adenomas found during long-term follow-up: analysis of four subsequent generations of adenoma recurrence. Scand J Gastroenterol; 2009;44(6):736-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characteristics of metachronous colorectal adenomas found during long-term follow-up: analysis of four subsequent generations of adenoma recurrence.
  • OBJECTIVE: Because of the high recurrence rates of colorectal adenomas, regular surveillance by colonoscopy has been recommended, but there is still a dearth of information on the long-term results of follow-up colonoscopy after polypectomy.
  • The aims of this study were to determine the differences between initial adenomas and metachronous lesions, to evaluate the effect of long-term surveillance and to describe the hypothetical origin of the colorectal adenoma-carcinoma sequence.
  • Statistical analysis using chi(2) testing of adenoma characteristics found in four subsequent recurrence periods was carried out, and the relative risk (RR) for the development of metachronous adenomas of advanced pathology was calculated.
  • RESULTS: In comparison with the initial findings, metachronous adenomas are generally significantly smaller lesions (p<0.00001), usually tubular in shape (p<0.00001) and bearing high-grade dysplasia less often (p<0.00001) and are usually located in the right colon (p<0.00001).
  • These differences are found between the initial and four subsequent generations of metachronous adenomas.
  • The number of synchronous adenomas is reduced only in the first recurrence (p<0.001); in the further generations equal proportions of multiplicity are found, as in the baseline examination.
  • Patients with adenomas of advanced pathology, i.e. large, tubulovillous or villous adenomas at baseline, have a significantly higher risk for large (RR 2.73; 95% CI 1.77-4.20), tubulovillous or villous (RR 1.55; 95% CI 1.06-2.25) or multiple (RR 2.45; 95% CI 1.83-3.29) metachronous adenomas at the first recurrence.
  • CONCLUSIONS: Metachronous adenomas show the uniform characteristics of being small tubular lesions rarely bearing high-grade dysplasia, usually located in the right colon.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Neoplasms, Second Primary

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  • (PMID = 19277927.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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88. Kaklamanis L, Trichas M, Amarantidis K, Spathari N, Micheli A, Karayiannakis A, Chatzaki E, Georgoulias V, Kakolyris S: VEGF expression in the colorectal adenoma-carcinoma sequence. Oncol Res; 2006;15(9):445-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] VEGF expression in the colorectal adenoma-carcinoma sequence.
  • VEGF and p53 expression were evaluated in 16 hyperplastic polyps, 35 solitary tubular and tubulovillous adenomas, and 47 cases of sporadic colorectal carcinomas arising on the basis of preexisting adenomas, using immunohistochemistry.
  • Carcinomas arising from VEGF-positive adenomas were mostly VEGF positive (10/11, 91%), whereas in 28/36 (78%) carcinomas arising from VEGF-negative adenomas VEGF expression was not detected.
  • We conclude that VEGF associates with angiogenesis in colorectal cancer, and its pattern of expression in adenomas is maintained in the arising carcinomas.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Colorectal Neoplasms / metabolism. Gene Expression. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 16555551.001).
  • [ISSN] 0965-0407
  • [Journal-full-title] Oncology research
  • [ISO-abbreviation] Oncol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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89. Hansel DE, Nadasdy T, Epstein JI: Fibromyxoid nephrogenic adenoma: a newly recognized variant mimicking mucinous adenocarcinoma. Am J Surg Pathol; 2007 Aug;31(8):1231-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibromyxoid nephrogenic adenoma: a newly recognized variant mimicking mucinous adenocarcinoma.
  • Nephrogenic adenomas demonstrate a variety of morphologic patterns that may occasionally be confused with malignant processes, including urothelial and prostatic carcinoma.
  • In this series, we describe 8 cases of nephrogenic adenoma that contain an admixture of the classic tubular form of nephrogenic adenoma and an unusual spindled and fibromyxoid form of nephrogenic adenoma that closely mimics infiltrating carcinoma.
  • In all cases, the classic tubular form of nephrogenic adenoma composed only a small proportion of the lesion, whereas the remainder consisted of compressed spindled cells within a fibromyxoid background, with only rare tubular and cordlike structures.
  • This case series is the first report of a fibromyxoid subtype of nephrogenic adenoma.
  • Awareness of this entity and the use of ancillary techniques can aid in the diagnosis of this unusual form of nephrogenic adenoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Fibroma / pathology. Urologic Neoplasms / pathology

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  • (PMID = 17667548.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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90. Levy BT, Daly JM, Luxon B, Merchant ML, Xu Y, Levitz CE, Wilbur JK: The "Iowa get screened" colon cancer screening program. J Prim Care Community Health; 2010 Apr 1;1(1):43-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thirteen individuals had at least 1 tubular adenoma; 2 had adenomas more than 1 cm in diameter, with no colon cancers identified.

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  • (PMID = 23804068.001).
  • [ISSN] 2150-1319
  • [Journal-full-title] Journal of primary care & community health
  • [ISO-abbreviation] J Prim Care Community Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; adenomatous polyp / colorectal cancer screening / fecal immunochemical testing / prevention / recruitment strategies / screening program / tubular adenoma / underinsured / uninsured
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91. McCloud JM, Waymont N, Pahwa N, Varghese P, Richards C, Jameson JS, Scott AN: Factors predicting early recurrence after transanal endoscopic microsurgery excision for rectal adenoma. Colorectal Dis; 2006 Sep;8(7):581-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors predicting early recurrence after transanal endoscopic microsurgery excision for rectal adenoma.
  • INTRODUCTION: Transanal endoscopic microsurgery (TEM) is an accepted way of excising rectal adenomas with low morbidity and mortality, avoiding major resectional surgery.
  • PATIENTS AND METHODS: Patients who had undergone TEM for rectal adenomas were identified, and a retrospective review of patient, pathological and histological parameters was performed.
  • There were seven tubular, 33 tubulo-villous and 35 villous adenomas.
  • There was no significant association between recurrence at 6 months and sex, age, type or position of adenoma, height above the anal verge, or degree of dysplasia.
  • Recurrence rates at six months were 0% for the completely excised adenomas and 21.4% for the incompletely excised ones; this was statistically significant (Pearson chi(2), P < 0.001).
  • In addition, a significant association for large adenomas to recur was noted at median follow up (Armitage Trend test, P = 0.019).
  • CONCLUSIONS: Histological assessment of completeness of excision of rectal adenoma and size of adenoma are important predictors of early recurrence and have potential to guide follow-up strategies after TEM.
  • [MeSH-major] Adenoma / surgery. Microsurgery. Neoplasm Recurrence, Local. Rectal Neoplasms / surgery

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  • (PMID = 16919110.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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92. Yamada T, Tamura S, Onishi S, Hiroi M: A comparison of magnifying chromoendoscopy versus histopathology of forceps biopsy specimen in the diagnosis of minute flat adenoma of the colon. Dig Dis Sci; 2009 Sep;54(9):2002-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of magnifying chromoendoscopy versus histopathology of forceps biopsy specimen in the diagnosis of minute flat adenoma of the colon.
  • Having noted a discrepancy between endoscopic and histopathological diagnoses in cases of minute adenomas of the colon, a prospective study was designed to clarify which is appropriate, magnifying chromoendoscopy or histopathology of a specimen obtained by biopsy forceps.
  • We separated the detected lesions with type III(L) pit pattern following Kudo's classification into two groups at random: in group A (n = 104) resected specimens were fixed with 20% buffered formalin without being flattened, whereas in group B (n = 104) the resected specimens were flattened using forceps before fixation and the specimens were cut under observation of their surface structure with stereomicroscopy.
  • Comparison of the initial diagnoses between groups A and B showed that a total of 84.6% (88/104) of the lesions were diagnosed to be tubular adenomas histopathologically in group A, compared with 100% (104/104) in group B (P < 0.0001).
  • Results for comparison of the secondary diagnoses between group A and group B showed that 14 of the 16 lesions were diagnosed as tubular adenomas histopathologically.
  • Thereafter, 98.1% (102/104) of the lesions were diagnosed to be tubular adenomas histopathologically in group A (P = 0.4976).
  • In conclusion, high-resolution magnifying chromoendoscopy is an appropriate procedure for the diagnosis of minute adenomas in comparison with histopathology of specimens obtained by biopsy forceps in this prospective study.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Colonoscopy / methods

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  • (PMID = 19037726.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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93. Mizoshita T, Tsukamoto T, Inada KI, Hirano N, Tajika M, Nakamura T, Ban H, Tatematsu M: Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. Histol Histopathol; 2007 03;22(3):251-60
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  • [Title] Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon.
  • MUC2 expression demonstrated a significant decrease from tubular/tubulovillous adenomas with moderate atypia, through intramucosal carcinomas, to cancers with submucosal invasion (P<0.0001).
  • Intramucosal de novo carcinomas (flat type carcinomas without adenomatous components) exhibited a greater decrease of MUC2 than intramucosal lesions with adenomatous components.
  • Expression of MUC5AC also decreased significantly with progression according to the tubular/tubulovillous adenoma-carcinoma sequence, carcinomas with villous adenomatous components having a higher level compared with their tubular adenomatous counterparts, suggesting differences in the pathway of malignant transformation.
  • Cdx2 nuclear expression was maintained in all of the adenomas and early carcinomas examined.
  • CONCLUSIONS: Our data suggest that the reduction of MUC2 expression may be associated with the occurrence and progression of colorectal carcinomas in both adenoma-carcinoma sequence pathway and de novo carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Villous / metabolism. Colorectal Neoplasms / metabolism. Mucins / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. CDX2 Transcription Factor. Cell Transformation, Neoplastic / pathology. Disease Progression. Female. Homeodomain Proteins / metabolism. Humans. Immunoenzyme Techniques. Male. Microfilament Proteins / metabolism. Mucin 5AC. Mucin-2. Mucin-6

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  • (PMID = 17163399.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 Transcription Factor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Microfilament Proteins; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins; 0 / villin
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94. Hall WC, Elder B, Walker CL, Cai SL, Peters DG, Goodman DG, Ulland BM, Borzelleca JF: Spontaneous renal tubular hyperplastic and neoplastic lesions in three Sprague-Dawley rats from a 90-day toxicity study. Toxicol Pathol; 2007 Feb;35(2):233-41
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  • [Title] Spontaneous renal tubular hyperplastic and neoplastic lesions in three Sprague-Dawley rats from a 90-day toxicity study.
  • Multiple renal tubular cell adenomas and atypical tubular hyperplasia were diagnosed in 2 high-dose and 1 mid-dose female Sprague-Dawley (Crl:CD (SD)IGS BR) rats from a 90-day toxicity study of an amino acid found in green tea.
  • The tumors were bilateral multicentric adenomas accompanied by atypical foci of renal tubular hyperplasia in both kidneys of the 3 animals.
  • Toxic tubular changes that typically accompany renal carcinogenesis were not seen in any of the other animals of the study, suggesting rather, an underlying germline mutation of a tumor suppressor gene in these three rats.
  • Nihon rats develop kidney tumors as a result of a spontaneous mutation in the rat homologue of the Birt-Hogg-Dubé gene (Bhd).
  • Taken together, these data suggest that the tumors observed in these animals arose spontaneously as a result of a shared genetic susceptibility leading to the development of renal tubular neoplasms.
  • [MeSH-major] Adenoma / chemically induced. Glutamates / toxicity. Kidney Neoplasms / chemically induced. Kidney Tubules / pathology

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  • (PMID = 17366317.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 63613; United States / NIEHS NIH HHS / ES / ES 07784
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flcn protein, rat; 0 / Glutamates; 0 / Proteins; 8021PR16QO / theanine
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95. Ghidirim G, Mişin I, Istrate V, Cazacu S: Endoscopic papillectomy into the treatment of neoplastic lesions of vater papilla. Curr Health Sci J; 2009 Apr;35(2):92-7

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  • Adenomas of the duodenal papilla are rare.
  • The frequency of malignant adenomas is 15-30%.
  • Villous adenoma is a premalignant lesion with the highest rate of transformation.
  • AIM: Evaluation of the efficacy and safety of endoscopic papillectomy for ampullary adenomas.
  • MATERIAL AND METHOD: 12 patients were selected (F:M, 5:7, age range 37 - 68 years) with ampullary adenoma, treated by endoscopic papillectomy.
  • RESULTS: En bloc resection was performed in 8 cases, and piecemeal resection in 4 cases.
  • Pathology examination has show: tubulo-villous adenoma (5 patients); villous adenoma (4 patients), tubular adenoma (2 cases), adenocarcinoma (one case).
  • CONCLUSION: Endoscopic papillectomy is a safe and well-tolerated alternative to surgical treatment of ampullary adenoma.

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  • (PMID = 24778815.001).
  • [ISSN] 2067-0656
  • [Journal-full-title] Current health sciences journal
  • [ISO-abbreviation] Curr Health Sci J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Other-IDs] NLM/ PMC3945241
  • [Keywords] NOTNLM ; Vater papilla / ampullary adenoma / bleeding / endoscopic papillectomy / pancreatitis / sphyncterotomy
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96. Boolchand V, Olds G, Singh J, Singh P, Chak A, Cooper GS: Colorectal screening after polypectomy: a national survey study of primary care physicians. Ann Intern Med; 2006 Nov 7;145(9):654-9
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  • MEASUREMENTS: Physicians were asked when they would recommend repeated colonoscopy for a hypothetical 55-year-old man with no family history of colorectal cancer after the following 6 results on colonoscopy: hyperplastic polyp, one 6-mm tubular adenoma, two 6-mm tubular adenomas, one 12-mm tubulovillous adenoma, one 12-mm tubular adenoma with focal high-grade dysplasia, and no polyp but a previous tubular adenoma.
  • Sixty-one percent of respondents would survey a hyperplastic polyp in 5 years or less, 71% would survey a single tubular adenoma in 3 years or less, and 80% would survey 2 tubular adenomas in 3 years or less.
  • CONCLUSION: Primary care physicians recommend postpolypectomy colonoscopic surveillance more frequently than is recommended by practice guidelines, especially if the colonoscopy showed a hyperplastic polyp or a single small adenoma.
  • [MeSH-minor] Adenoma, Villous / diagnosis. Adenoma, Villous / surgery. Adenomatous Polyps / diagnosis. Adenomatous Polyps / surgery. Cross-Sectional Studies. Female. Follow-Up Studies. Guideline Adherence. Humans. Hyperplasia / diagnosis. Hyperplasia / surgery. Male. Middle Aged. Practice Guidelines as Topic. Risk Factors. Surveys and Questionnaires. Time Factors. United States

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  • [CommentIn] Ann Intern Med. 2007 Jun 5;146(11):820; author reply 820-1 [17548417.001]
  • [CommentIn] Ann Intern Med. 2007 Jun 5;146(11):820; author reply 820-1 [17548416.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2006 Nov 7;145(9):I26 [17088574.001]
  • (PMID = 17088578.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K05 CA90677; United States / NIDDK NIH HHS / DK / K24 DK002800
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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97. Cossu-Rocca P, Contini M, Brunelli M, Festa A, Pili F, Gobbo S, Eccher A, Mura A, Massarelli G, Martignoni G: S-100A1 is a reliable marker in distinguishing nephrogenic adenoma from prostatic adenocarcinoma. Am J Surg Pathol; 2009 Jul;33(7):1031-6
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  • [Title] S-100A1 is a reliable marker in distinguishing nephrogenic adenoma from prostatic adenocarcinoma.
  • Nephrogenic adenoma is a benign lesion that may occur at any site of the genitourinary tract, usually in association with previous urothelial injuries.
  • Although its pathogenesis is still debated, recent studies seem to confirm its derivation from renal tubular epithelium, rather than from a metaplastic process of urothelium.
  • In addition to its uncertain origin, there can be diagnostic difficulty in distinguishing nephrogenic adenoma from prostatic adenocarcinoma, particularly with lesions arising in the prostatic urethra.
  • S100A1 is a calcium binding protein that has been recently reported to be expressed in renal tubular cells and in a subset of renal cell neoplasms.
  • In this study, we investigated the expression of S100A1 and AMACR in 18 nephrogenic adenomas and in 100 prostatic adenocarcinomas.
  • A strong and distinct cytoplasmic or nucleocytoplasmic staining of S100A1 was found in 17 out of 18 cases of nephrogenic adenoma (94%), but never in prostatic adenocarcinoma.
  • In contrast, AMACR expression was detected in 14 of 18 nephrogenic adenomas (78%) and in 96 of 100 prostatic adenocarcinomas (96%).
  • We conclude that (1) S100A1 is a specific and sensitive immunohistochemical marker to differentiate nephrogenic adenoma from prostatic adenocarcinoma;.
  • (3) given that both S100A1 and AMACR have been reported to be expressed in renal tubular cells and in a subset of renal cell neoplasms, our findings confirm the histogenetic relationship between nephrogenic adenoma and renal tubular epithelium.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Prostatic Neoplasms / diagnosis. S100 Proteins / biosynthesis. Urogenital Neoplasms / diagnosis

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  • (PMID = 19384190.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / S100A1 protein; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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98. Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO: Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium. J Biol Chem; 2005 Feb 04;280(5):3938-45
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  • [Title] Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium.
  • Analysis of these adults revealed severely cystic kidneys associated with the presence of renal adenomas.
  • [MeSH-major] Adenoma / physiopathology. Genes, APC / physiology. Kidney Neoplasms / physiopathology. Polycystic Kidney Diseases / physiopathology

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  • (PMID = 15550389.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P50 DK057328; United States / NIDDK NIH HHS / DK / R01 DK067565; United States / NIDDK NIH HHS / DK / DK-42921; United States / NIDDK NIH HHS / DK / DK-57328; United States / NIDDK NIH HHS / DK / R01 DK042921; United States / NIDDK NIH HHS / DK / DK-67565
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, mouse; 0 / Cytoskeletal Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Trans-Activators; 0 / Wnt Proteins; 0 / beta Catenin; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases
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99. Zhang WW, Ren BJ, Tong HS, Zhang YL, Jiang P: [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 May;9(3):250-2
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  • [Title] [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases].
  • OBJECTIVE: To explore the endoscopic and histopathological morphology of large intestinal serrated adenomas (SA).
  • RESULTS: Forty-seven of the 71 serrated adenomas were protruded (sessile 23, semipedunculated 5, pedunculated 23) and 24 were superficial (flat 16, laterally spreading 8).
  • Histopathologically, SA contained tubular glands in 53, tubulovillous glands in 9 and villous glands in 9 cases.
  • Most IV and III L pit SAs presented villous glands (64%) and tubular glands (68%), respectively.
  • 40% of hyperplastic polyps-like SAs, composed of tubular glands,showed II pit pattern.
  • [MeSH-major] Adenoma / pathology. Colonoscopy. Colorectal Neoplasms / pathology

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  • (PMID = 16721690.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
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100. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
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  • [Title] Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case.
  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.
  • We describe a 61-year-old man with syringocystadenoma papilliferum developing within a nevus sebaceus with sebaceous differentiation in an intradermal tubular apocrine component of the syringocystadenoma papilliferum.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18212545.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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