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1. Lin CW, Yuan F: Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork. Ann Biomed Eng; 2010 Mar;38(3):935-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork.
  • Topical application of drugs for treatment of intraocular diseases is often limited by inadequate transport and induced toxicity in corneal tissues.
  • To improve the drug delivery, a mathematical model was developed to numerically simulate the transport process of ethacrynic acid (ECA), a potential drug for glaucoma treatment, in the anterior segment of a typical human eye.
  • In addition, the main pathway for ECA clearance from the eye was the trabecular meshwork (TM) and the rate of clearance was approximately proportional to the AH production rate.
  • The model predicted that the most effective approach to improving topical drug delivery was to prolong its half-life in the precorneal tear film.
  • These simulation results and model prediction, which could be verified experimentally, might be useful for improving delivery of ECA and other therapeutic agents to the TM as well as other tissues in the anterior segment of the eye.
  • [MeSH-major] Adenoma / chemistry. Cornea / chemistry. Ethacrynic Acid / chemistry. Models, Biological. Models, Chemical
  • [MeSH-minor] Biological Transport. Computer Simulation. Diffusion. Enzyme Inhibitors / chemistry. Humans

  • Hazardous Substances Data Bank. ETHACRYNIC ACID .
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  • (PMID = 20140518.001).
  • [ISSN] 1573-9686
  • [Journal-full-title] Annals of biomedical engineering
  • [ISO-abbreviation] Ann Biomed Eng
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; M5DP350VZV / Ethacrynic Acid
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2. Richart J, Brunt EM, Di Bisceglie AM: Expression of P-glycoprotein and C-MOAT in human hepatocellular carcinoma: detection by immunostaining. Dig Dis Sci; 2002 Nov;47(11):2454-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • P-Glycoprotein and C-MOAT are important hepatic transport proteins which play a role in handling anticancer drugs.
  • Hepatocellular carcinoma is a common hepatic malignancy that is relatively resistant to chemotherapeutic drugs.
  • We therefore studied the expression of these two transport proteins in liver sections from hepatocellular carcinoma by immunohistochemistry and compared the reactivity to that in other liver conditions, including cirrhosis and dysplasia.
  • We studied 53 sections from 17 liver specimens and found that the majority of samples stained positively for both P-glycoprotein and C-MOAT; however, the degree of staining was less in HCC and hepatic adenoma than in liver adjacent to HCC or in cirrhosis or dysplastic nodules.
  • HCC with a compact pattern had less staining than those with acinar, scirrhous, or trabecular patterns.
  • [MeSH-major] Carcinoma, Hepatocellular / metabolism. Liver / metabolism. Liver Neoplasms / metabolism. Multidrug Resistance-Associated Proteins / metabolism. P-Glycoprotein / metabolism
  • [MeSH-minor] Adenoma / metabolism. Humans. Immunohistochemistry. Liver Cirrhosis / metabolism

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  • (PMID = 12452378.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ABCC5 protein, human; 0 / Multidrug Resistance-Associated Proteins; 0 / P-Glycoprotein
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3. Sharma V, Cui H, Whalen G, Khan A, Torres M: A case of trabecular adenoma of the thyroid with black pigmentation. Thyroid; 2007 Jun;17(6):593-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of trabecular adenoma of the thyroid with black pigmentation.
  • [MeSH-major] Adenoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Acne Vulgaris / drug therapy. Humans. Male. Middle Aged. Minocycline / adverse effects. Pigmentation

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  • (PMID = 17614784.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] FYY3R43WGO / Minocycline
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4. Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M: mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res; 2004 Dec 15;10(24):8421-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • EXPERIMENTAL DESIGN: Total and phosphorylated mTOR and S6K protein expression were studied by immunohistochemistry in hepatocellular carcinomas (n = 73), fibrolamellar carcinomas (n = 13), and hepatic adenomas (n = 15).
  • Results were correlated with tumor growth pattern as defined by the WHO (trabecular, pseudoglandular/acinar, compact, and scirrhous), tumor size, Ki-67 proliferation index, and the modified Edmondson nuclear grade, which has a scale of 1 to 4.
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Antibiotics, Antineoplastic / pharmacology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cell Proliferation / drug effects. Female. Genetic Heterogeneity. Hepatitis / metabolism. Hepatitis / pathology. Humans. Immunoenzyme Techniques. Ki-67 Antigen / metabolism. Male. Middle Aged. Phosphorylation / drug effects. Sirolimus / pharmacology. TOR Serine-Threonine Kinases. Tumor Cells, Cultured / drug effects

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  • (PMID = 15623621.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Ki-67 Antigen; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa; W36ZG6FT64 / Sirolimus
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