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1. Nakabayashi M, Shomori K, Kiya S, Shiomi T, Nosaka K, Ito H: Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report. Yonago Acta Med; 2010 Sep;53(3):65-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report.
  • Basal cell adenoma (BCA) is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells.
  • Histopathologically, the tumor was characterized by multiple duct-like structures and tubular-trabecular masses composed of small isomorphic cells with hyperchromatic, round nuclei and an eosinophilic cytoplasm.

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  • (PMID = 24031120.001).
  • [ISSN] 0513-5710
  • [Journal-full-title] Yonago acta medica
  • [ISO-abbreviation] Yonago Acta Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3763784
  • [Keywords] NOTNLM ; basal cell adenoma / immunohistochemistry / parotid gland
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2. Lack of BRAF mutations in hyalinizing trabecular neoplasm. Cytojournal; 2006 Jul 25;3:17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lack of BRAF mutations in hyalinizing trabecular neoplasm.
  • The hyalinizing trabecular neoplasm (HTN) of the thyroid is an unusual and controversial lesion.
  • Others consider it an adenoma.
  • We report two cases of classic HTN and a case of trabecular PTC and show BRAF mutations in the latter and not in HTN.
  • Trabecular growth pattern is insufficient for a diagnosis of HTN and lesions with such a pattern and nuclear features of PTC are cancers.
  • Morphologically classic HTN are not associated with metastatic potential and should be considered adenomas.

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  • (PMID = 16867191.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC1544348
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3. Kang SW, Hong SW, Yeon PJ, Jeong JJ, Sung TY, Lee SC, Lee YS, Nam KH, Chung WY, Chang HS, Park CS: A case of black thyroid associated with hyalinizing trabecular tumor. Endocr J; 2008 Dec;55(6):1109-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of black thyroid associated with hyalinizing trabecular tumor.
  • We describe here a 42-year-old woman with a black thyroid associated with hyalinizing trabecular tumor (HTT).
  • Histopathologically, numerous black pigmented follicular epithelial cells and colloid were seen throughout the thyroid parenchyma, and the nodule was composed of elongated, polygonal cells in trabecular arrangement and dense hyaline stromas.
  • All of these findings suggested a HTT, or a hyalinizing trabecular variant of papillary carcinoma, arising in a black thyroid.
  • [MeSH-major] Adenoma / diagnosis. Pigmentation / physiology. Thyroid Gland / physiopathology. Thyroid Neoplasms / diagnosis

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  • (PMID = 18753707.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Saliba I, Evrard AS: Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series. Cases J; 2009;2:6508

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series.
  • RESULTS: Ninety-four patients with a middle ear adenoma are included in this report.
  • We uncovered 75 patients with a carcinoid tumor and 19 patients with a middle ear adenoma diagnosis; the most common presenting symptom was a conductive hearing loss.
  • Middle ear adenomas are lesions that are typically white, gray or reddish brown.
  • Histologically, the cuboidal to low columnar cells are arranged in a solid, trabecular or glandular architecture.
  • CONCLUSIONS: Our study and the review of the literature showed adenomas and carcinoid tumors of the middle ear to be essentially indistinguishable benign tumors with metastatic potential.

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  • (PMID = 20111612.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2812983
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5. Galgano MT, Mills SE, Stelow EB: Hyalinizing trabecular adenoma of the thyroid revisited: a histologic and immunohistochemical study of thyroid lesions with prominent trabecular architecture and sclerosis. Am J Surg Pathol; 2006 Oct;30(10):1269-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing trabecular adenoma of the thyroid revisited: a histologic and immunohistochemical study of thyroid lesions with prominent trabecular architecture and sclerosis.
  • BACKGROUND: Since its description, hyalinizing trabecular adenoma (HTA) of the thyroid has been a controversial entity.
  • DESIGN: Our files were reviewed for all thyroid resection reports describing lesions with hyalinized or sclerotic stroma and a trabecular architecture within the diagnosis or diagnostic comment.
  • RESULTS: Eighteen thyroid lesions with prominent sclerosis or hyalinization and trabecular architecture were identified.
  • The other cases showed histologic features more compatible with other diagnoses including cellular adenomatoid nodule (5), follicular adenoma (4), follicular variant of PC (FVPC) (3), and epithelial neoplasm with features of FVPC (2).
  • All cases deemed to be adenomatoid nodules, follicular adenomas and epithelial neoplasms showed no immunoreactivity for HBME1 and CK19 and, of these, only a single AN showed immunoreactivity for p63.
  • CONCLUSIONS: A sclerotic or hyalinized stroma with a trabecular growth pattern may be seen in a number of different thyroid lesions and, when seen, is usually a focal feature of a lesion other than HTA.
  • [MeSH-major] Adenoma / pathology. Hyalin / metabolism. Immunohistochemistry / methods. Sclerosis / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17001158.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HBME-1 antigen; 68238-35-7 / Keratins
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6. Giove E, Lavermicocca W, Merlicco D, Renzulli G, Nacchiero E: [Diagnosis, surgical treatment and follow-up of the hyalizing trabecular adenoma of the thyroid]. Ann Ital Chir; 2009 Nov-Dec;80(6):423-7; discussion 427-8
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  • [Title] [Diagnosis, surgical treatment and follow-up of the hyalizing trabecular adenoma of the thyroid].
  • [Transliterated title] Diagnosi, trattamento chirurgico e follow-up dell'adenoma trabecolare ialinizzante della tiroide.
  • We found only in ten patients a hyalinizing trabecular adenoma at the (histological control), as a confirmation of the rarity of this tumour.
  • In conclusion the hyalinizing trabecular adenoma represents a low malignant potential tumour.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery

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  • (PMID = 20476672.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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7. Giove E, Lavermicocca W, Merlicco D, Renzulli G, Nacchiero E: [Diagnosis, surgical treatment and follow-up of the hyalizing trabecular adenoma of the thyroid]. Ann Ital Chir; 2009 Sep-Oct;80(5):357-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis, surgical treatment and follow-up of the hyalizing trabecular adenoma of the thyroid].
  • [Transliterated title] Diagnosi, trattamento chirurgico e follow-up dell'adenoma trabecolare ialinizzante della tiroide.
  • We found only in ten patients a hyalinizing trabecular adenoma at the (histological control), as a confirmation of the rarity of this tumour.
  • In conclusion the hyalinizing trabecular adenoma represents a low malignant potential tumour.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery

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  • [ErratumIn] Ann Ital Chir. 2009 Nov-Dec;80(6):3 p preceding table of contents. Nacchiero, Michele [corrected to Nacchiero, Eleonora]
  • (PMID = 20131547.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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8. Antoniades D, Epivatianos A, Markopoulos A, Kolokotronis A, Zaraboukas T: Coexistence of mucous retention cyst and basal cell adenoma arising from the lining epithelium of the cyst. Report of two cases. Med Princ Pract; 2009;18(3):248-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of mucous retention cyst and basal cell adenoma arising from the lining epithelium of the cyst. Report of two cases.
  • OBJECTIVE: To report 2 cases of coexisting mucous retention cyst and basal cell adenoma arising from the lining epithelium of the cyst.
  • Histological examination showed the presence of a large unilocular cystic cavity in many parts surrounded by single or bilayered lining epithelium composed of flattened to cuboidal cells, and in other parts surrounded by projections of cells arranged in a trabecular pattern far into the cystic cavity.
  • Based on the results, a diagnosis of coexisting mucous retention cysts and basal cell adenomas arising from the lining epithelium of cysts was made.
  • CONCLUSION: The coexistence of mucous retention cysts and basal cell adenomas arising from the lining epithelium of the cyst is reported.
  • [MeSH-major] Adenoma / complications. Adenoma / pathology. Mucocele / complications. Mucocele / pathology. Salivary Gland Diseases / complications. Salivary Gland Diseases / pathology

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19349732.001).
  • [ISSN] 1423-0151
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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9. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO: Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg; 2007 Jun;193(6):707-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma.
  • BACKGROUND: Hyalinizing trabecular adenoma (HTA) is an uncommon benign thyroid tumor that can present as a solitary thyroid nodule, a prominent nodule in a multinodular goiter, or as an incidental finding in a thyroidectomy specimen.
  • [MeSH-major] Adenoma / pathology. Diagnostic Errors. Thyroid Neoplasms / pathology

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  • (PMID = 17512281.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Carney JA, Hirokawa M, Lloyd RV, Papotti M, Sebo TJ: Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol; 2008 Dec;32(12):1877-89
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing trabecular tumors of the thyroid gland are almost all benign.
  • In 1987, Carney et al reported 11 thyroid tumors with the following features: circumscription or encapsulation, trabecular architecture with intratrabecular hyalin and colloid, polygonal and spindle cells, nuclei with frequent grooves and cytoplasmic inclusions, occasional psammoma bodies, and a low mitotic rate.
  • The neoplasms did not recur or metastasize during a follow-up period that averaged 10 years, and they were titled hyalinizing trabecular adenomas.
  • Subsequently, the nuclear features of the neoplasm led to the introduction of 2 modified titles for it, hyalinizing trabecular tumor and hyalinizing trabecular neoplasm.
  • We conclude that the overwhelming majority of hyalinizing trabecular tumors of the thyroid behave as benign neoplasms and that, at this time, hyalinizing trabecular adenoma is the most appropriate title for them.
  • [MeSH-major] Adenoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18813121.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Volante M, Papotti M: A practical diagnostic approach to solid/trabecular nodules in the thyroid. Endocr Pathol; 2008;19(2):75-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A practical diagnostic approach to solid/trabecular nodules in the thyroid.
  • Nodules having a non-follicular-non-papillary structure may be frequently encountered in the thyroid, the solid/trabecular arrangement being the most common feature.
  • When solid/trabecular pattern is predominant within a thyroid nodule, the wide range of differential diagnoses represents one of the major diagnostic problems in the routine thyroid practice, including--among others--relatively frequent entities such as trabecular adenoma or solid variant of papillary carcinoma and rare tumors such as hyalinizing trabecular tumor or paraganglioma.
  • Morphology alone may not be sufficient to proper-type solid/trabecular tumors in the thyroid and, therefore, a panel of immunohistochemical markers is recommended, including thyroglobulin/calcitonin as the first step, followed by specific markers according to the morphological and clinical setting.
  • A schematic algorithm is presented, which takes into consideration the diagnostic hallmarks of the most relevant entities that enter in the differential diagnosis in solid/trabecular nodules within the thyroid.

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  • (PMID = 18409025.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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12. Carney JA: Hyalinizing trabecular tumors of the thyroid gland: quadruply described but not by the discoverer. Am J Surg Pathol; 2008 Apr;32(4):622-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyalinizing trabecular tumors of the thyroid gland: quadruply described but not by the discoverer.
  • Hyalinizing trabecular tumors of the thyroid have been described on 4 occasions, by Carney and colleagues in 1987, by Ward and coworkers in 1982, by Pierre Masson in 1922, and by Rahel Zipkin in 1905.
  • Carney and colleagues labeled the neoplasms hyalinizing trabecular adenomas because of their microscopic appearance, absence of invasion, and benign natural history.
  • Subsequently, the nuclear features of the tumor and the molecular genetic findings led to the introduction of equivocal designations for it, hyalinizing trabecular tumor and hyalinizing trabecular neoplasm, and later to its designation as a variant of papillary carcinoma.
  • Hyalinizing trabecular carcinoma is a very rare tumor.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Papillary / pathology. Hyalin / metabolism. Terminology as Topic. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18367942.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Historical Article; Journal Article; Portraits
  • [Publication-country] United States
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13. Sheu SY, Vogel E, Worm K, Grabellus F, Schwertheim S, Schmid KW: Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma. Histopathology; 2010 Apr;56(5):632-40
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  • [Title] Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma.
  • AIMS: To compare the expression pattern of five microRNAs (miRNAs) (146b, -181b, -21, -221, -222) of papillary thyroid carcinoma (PTC) and hyalinizing trabecular tumour of the thyroid (HTT).
  • METHODS AND RESULTS: The expression pattern of five miRNAs known to be up-regulated in PTC was retrospectively analysed in 18 HTTs, adjacent normal thyroid tissue, 10 PTCs, 10 follicular adenomas and 10 non-toxic multinodular goitres (MNG) by reverse transcriptase-polymerase chain reaction using the TaqMan miRNA assay.
  • All miRNAs were significantly up-regulated in PTCs, whereas all miRNAs in HTT, normal thyroid tissue, adenomas, and MNGs were down-regulated.
  • It is suggested that HTTs lacking both a miRNA expression pattern characteristic for PTC and RET/PTC rearrangements are re-designated as 'hyalinizing trabecular adenomas'.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenoma / genetics. MicroRNAs / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 20459574.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / Oncogene Proteins, Fusion; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / ret-PTC fusion oncoproteins, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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14. Nosé V, Volante M, Papotti M: Hyalinizing trabecular tumor of the thyroid: an update. Endocr Pathol; 2008;19(1):1-8
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  • [Title] Hyalinizing trabecular tumor of the thyroid: an update.
  • Hyalinizing trabecular tumor (HTT) is a rare thyroid tumor of follicular cell origin with a trabecular pattern of growth and marked intratrabecular hyalinization.
  • [MeSH-major] Adenoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17960500.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Ki-67 Antigen; 68238-35-7 / Keratins; 9007-12-9 / Calcitonin
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15. Dundr P, Povýsil C, Zelinka T, Tvrdík D, Ciprová V, Novák K: Adrenocortical adenoma with rhabdoid features. Pathol Res Pract; 2006;202(3):177-81
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  • [Title] Adrenocortical adenoma with rhabdoid features.
  • We report a case of an aldosterone producing adrenocortical adenoma with rhabdoid features in a 16-year-old girl.
  • Histologically, the tumor was composed of approximately equal parts of tumor cells with rhabdoid features arranged in a solid and trabecular pattern and cells characterized by compact eosinophilic cytoplasm, solid growth with focal necroses, and increased mitotic activity.
  • Rhabdoid features have been described in many tumors of variable histogenesis; however, to the best of our knowledge, the presence of rhabdoid phenotype has never been described in either adrenocortical adenoma or carcinoma.
  • [MeSH-major] Adrenal Cortex Neoplasms / pathology. Adrenocortical Adenoma / pathology. Rhabdoid Tumor / metabolism

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  • (PMID = 16448785.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 4964P6T9RB / Aldosterone
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16. Lin CW, Yuan F: Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork. Ann Biomed Eng; 2010 Mar;38(3):935-44
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  • [Title] Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork.
  • In addition, the main pathway for ECA clearance from the eye was the trabecular meshwork (TM) and the rate of clearance was approximately proportional to the AH production rate.
  • [MeSH-major] Adenoma / chemistry. Cornea / chemistry. Ethacrynic Acid / chemistry. Models, Biological. Models, Chemical

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  • (PMID = 20140518.001).
  • [ISSN] 1573-9686
  • [Journal-full-title] Annals of biomedical engineering
  • [ISO-abbreviation] Ann Biomed Eng
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; M5DP350VZV / Ethacrynic Acid
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17. Bai X, Li N, Wang F, Li S, Yu Q: Primary ovarian trabecular carcinoid tumor: a case report and literature review. Arch Gynecol Obstet; 2010 Oct;282(4):407-11
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  • [Title] Primary ovarian trabecular carcinoid tumor: a case report and literature review.
  • Multiple sections showed that the tumor was a total epithelial neoplasia with a trabecular structure surrounded by dense connective tissue.
  • Silver staining showed neuroendocrine granules, and reticulin staining showed that tumor cells were arranged in a trabecular structure.
  • Finally, the case was diagnosed as a primary ovarian trabecular carcinoid tumor.
  • CONCLUSION: Primary ovarian trabecular carcinoid tumors are very rare.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Neoplasms, Glandular and Epithelial / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 20652280.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen
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18. Sharma V, Cui H, Whalen G, Khan A, Torres M: A case of trabecular adenoma of the thyroid with black pigmentation. Thyroid; 2007 Jun;17(6):593-4
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  • [Title] A case of trabecular adenoma of the thyroid with black pigmentation.
  • [MeSH-major] Adenoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17614784.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] FYY3R43WGO / Minocycline
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19. Trapani F, Del Basso De Caro ML, Insabato L, Papparella S, Paciello O: Type II muscle fibers atrophy associated with silent corticotroph adenoma in a dog. Folia Histochem Cytobiol; 2010 Sep 30;48(3):403-6
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  • [Title] Type II muscle fibers atrophy associated with silent corticotroph adenoma in a dog.
  • The Silent Corticotroph Adenoma (SCA) is a pituitary adenoma variant characterized by the immunoreactivity for adrenocorticotropic hormone (ACTH) and related peptides, without the clinical signs of Cushing's disease.
  • We describe a case of type II muscle fibers atrophy associated with silent corticotroph adenoma in a dog.
  • The tumour showed a trabecular growth pattern and immunohistochemical analysis demonstrated the presence of cytoplasmic immunoreactivity for ACTH.

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  • (PMID = 21071346.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases; EC 1.3.99.1 / Succinate Dehydrogenase; EC 1.6.- / NADH Tetrazolium Reductase
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20. Lee DK, Chung KW, Baek CH, Jeong HS, Ko YH, Son YI: Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):884-8
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  • [Title] Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging.
  • OBJECTIVE: The goal of this study was to report the radiologic characteristics of basal cell adenoma of the parotid gland, which is a relatively rare neoplasm.
  • METHODS: A radiology and otolaryngology specialist reviewed the 2-phase helical computed tomography (CT) (n = 6) and/or magnetic resonance (MR) imaging (n = 2) scans of 7 patients with basal cell adenoma.
  • Meanwhile, the tumors with large cystic areas (n = 2) showed gradual and additional enhancement on the delayed phase and were classified as the tubular or trabecular subtype on pathologic evaluation.
  • CONCLUSIONS: Basal cell adenomas of the parotid gland present as small well-marginated tumors and appear as masses with central large cysts or solid masses with microcysts on CT and MR imaging scans.
  • Basal cell adenomas of the parotid gland had at least 2 different enhancement patterns on the 2-phase helical CT scans, and the enhancement patterns and imaging architecture were related to the histologic subtype of the tumors.
  • [MeSH-major] Adenoma / diagnosis. Magnetic Resonance Imaging / methods. Parotid Gland / pathology. Parotid Gland / radiography. Parotid Neoplasms / diagnosis. Tomography, Spiral Computed / methods

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  • (PMID = 16272868.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; JR13W81H44 / Iopamidol
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21. Ippolito G, Palazzo FF, Sebag F, De Micco C, Henry JF: Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma. Br J Surg; 2007 May;94(5):566-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma.
  • BACKGROUND: Distinction of parathyroid cancer from atypical parathyroid adenoma (APA) at operation is difficult.
  • Parathyroid cancer was defined as a lesion with vascular or tissue invasion, and APA as a neoplasm with broad fibrous bands, trabecular growth, mitosis and nuclear atypia.
  • [MeSH-major] Adenoma / diagnosis. Parathyroid Neoplasms / diagnosis. Parathyroidectomy / methods

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  • [CommentIn] Br J Surg. 2007 Aug;94(8):1043; author reply 1043-4 [17636522.001]
  • [CommentIn] Br J Surg. 2007 Aug;94(8):1042-3; author reply 1043-4 [17636521.001]
  • (PMID = 17380564.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Buła G, Waler J, Niemiec A, Koziołek H, Bichalski W, Gawrychowski J: Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy. Endokrynol Pol; 2010 Sep-Oct;61(5):427-9
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  • Intraoperative histopathology confirmed the presence of metastasis from renal clear cell carcinoma (1) and indicated thyroid medullary cancer (1), follicular tumour (4), or trabecular adenoma with necrosis (1).
  • [MeSH-minor] Adenoma / pathology. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Neuroendocrine. Female. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Middle Aged. Monitoring, Intraoperative / methods

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  • (PMID = 21049452.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Thyroid cancer, medullary
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23. Daneshbod Y, Negahban S, Khademi B, Daneshbod K: Epithelial myoepithelial carcinoma of the parotid gland with malignant ductal and myoepithelial components arising in a pleomorphic adenoma: a case report with cytologic, histologic and immunohistochemical correlation. Acta Cytol; 2007 Sep-Oct;51(5):807-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial myoepithelial carcinoma of the parotid gland with malignant ductal and myoepithelial components arising in a pleomorphic adenoma: a case report with cytologic, histologic and immunohistochemical correlation.
  • BACKGROUND: To describe the cytologic, histologic and immunohistochemical findings of a case of epithelial myoepithelial carcinoma (EMC) arising from a pleomorphic adenoma (PA) of the parotid with both malignant epithelial and myoepithelial components.
  • Fine needle aspiration biopsy (FNAB) revealed biphasic epithelial (small cell) and myoepithelial (large/clear cell) clusters arranged in a pseudopapillary and trabecular pattern with abundant hyaline material with many naked nuclei, together with areas typical of pleomorphic adenoma (PA) was noted.
  • The cytology was reported as salivary gland neoplasm, "suggestive of adenoid cystic carcinoma, less likely pleomorphic adenoma."
  • The mass was excised and histologically reported as "pleomorphic adenoma, with focal invasion of one resected margin."
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Myoepithelioma / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology


24. Negahban S, Daneshbod Y, Shishegar M: Clear cell carcinoma arising from pleomorphic adenoma of a minor salivary gland: Report of a case with fine needle aspiration, histologic and immunohistochemical findings. Acta Cytol; 2006 Nov-Dec;50(6):687-90
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  • [Title] Clear cell carcinoma arising from pleomorphic adenoma of a minor salivary gland: Report of a case with fine needle aspiration, histologic and immunohistochemical findings.
  • BACKGROUND: Malignant changes in pleomorphic adenoma (PA) of the salivary gland (carcinoma ex pleomorphic adenoma) are not common.
  • Also noted were large and small papillary, trabecular and well-circumscribed clusters of neoplastic cells with a moderate amount offoamy, vacuolated cytoplasm with distinct borders.
  • The final diagnosis was clear cell carcinoma expleomorphic adenoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenoma, Pleomorphic / pathology. Neoplasms, Second Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 17152285.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Okahara M, Kiyosue H, Matsumoto S, Hori Y, Tanoue S, Uchida D, Mori H, Kondo Y: Basal cell adenoma of the parotid gland: MR imaging findings with pathologic correlation. AJNR Am J Neuroradiol; 2006 Mar;27(3):700-4
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  • [Title] Basal cell adenoma of the parotid gland: MR imaging findings with pathologic correlation.
  • BACKGROUND AND PURPOSE: Basal cell adenomas (BCAs) are rare tumors of the parotid gland.
  • RESULTS: On pathologic examination, 5 tumors were solid type, 2 were trabecular type, and 1 was membranous type.
  • [MeSH-major] Adenoma / pathology. Magnetic Resonance Imaging. Parotid Neoplasms / pathology

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  • (PMID = 16552019.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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26. Kameyama K, Ito K, Takami H: [Pathology of benign thyroid tumor]. Nihon Rinsho; 2007 Nov;65(11):1973-8
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  • True benign neoplasm of the thyroid gland is only follicular adenoma, which is a tumor derived from follicular cells.
  • Follicular adenoma is well-circumscribed, with no evidence of capsular or vascular invasion.
  • The architectural pattern of follicular adenoma varies from trabecular to macrofollicular, and in most instances more than one architectural pattern is observed in one tumor.
  • [MeSH-major] Adenoma / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18018557.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 2
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27. Khadilkar UN, Maji P: Histopathological study of solitary nodules of thyroid. Kathmandu Univ Med J (KUMJ); 2008 Oct-Dec;6(24):486-90

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  • One case each of hyalinising trabecular adenoma, columnar cell variant of papillary carcinoma and medullary carcinoma unusually presenting as solitary nodules were encountered in the present study.

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  • (PMID = 19483430.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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28. Fischer I, Wieczorek R, Sidhu GS, Pei Z, West B, Lee P: Myxoid lipoadenoma of parathyroid gland: a case report and literature review. Ann Diagn Pathol; 2006 Oct;10(5):294-6
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  • Myxoid lipoadenoma of the parathyroid gland is a rare variant of parathyroid adenoma.
  • We present the case of a 40-year-old man with asymptomatic hypercalcemia who underwent surgical removal of a parathyroid adenoma.
  • Histologically, the tumor consisted of monomorphous round-to-oval chief cells arranged in several architectural patterns including solid sheet-like, trabecular, and follicular.
  • Although the lesion exhibited characteristics that have been previously associated with "atypical parathyroid adenoma," such as dense fibrous bands within the tumor and a trabecular growth pattern, there was no further evidence, neither histologically nor clinically, for malignant behavior of the tumor.
  • [MeSH-major] Adenoma / pathology. Adipose Tissue / pathology. Lipoma / pathology. Parathyroid Neoplasms / pathology

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  • (PMID = 16979523.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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29. Sorrentino F, Atzeni J, Romano G, Buscemi G, Romano M: [Differentiated microcarcinoma of the thyroid gland]. G Chir; 2010 Jun-Jul;31(6-7):277-8
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  • The PTMC was associated with cancer in only 2 cases (papillary carcinoma and parathyroid carcinoma) in the remaining thyroid tissue was suffering from benign disease (20 goiters, 3 Hashimoto thyroiditis, a trabecular adenoma).

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  • (PMID = 20646369.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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30. Saruya S, Nagamine H, Komiya T, Ito S, Iino Y, Kodera K, Imamura T: [Immunohistochemical and clinical features of patients with benign middle ear tumors]. Nihon Jibiinkoka Gakkai Kaiho; 2007 May;110(5):403-9
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  • We report six patients with benign middle ear tumors surgicaly removed: three with carcinoid, one with adenoma, and two with paraganglioma.
  • These tumors showed similar histological features in trabecular and glandular architecture, so further immunohistochemical study was needed to make a definitive histopathological diagnosis.
  • When we analyzed clinical features of patients diagnosed immunohistochemically, the differentiation of two patients with paraganglioma from the remaining four with adenomatous tumors such as adenoma and carcinoid was relatively easy from otomicroscopic findings and enhancement in temporal bone MRI.
  • [MeSH-major] Adenoma / pathology. Carcinoid Tumor / pathology. Ear Neoplasms / pathology. Ear, Middle. Paraganglioma / pathology

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  • (PMID = 17564130.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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31. Kimura N, Komuro K, Uchino S, Yagihashi S, Ishidate T, Ishizaka M: Multiple endocrine neoplasia type 1-associated cystic pancreatic endocrine neoplasia and multifocal cholesterol granulomas. Pathol Int; 2010 Apr;60(4):321-5
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  • A novel combination of tumors was found in a 68 year-old female with Multiple Endocrine Neoplasia type-1 (MEN 1) that included a cystic pancreatic endocrine neoplasm (CPEN), a pituitary adenoma, and multifocal cholesterol granulomas (MCGs) in the breast, pleura, and the extremities.
  • The tumor showed heterogeneity in the architecture that included glandular, trabecular and solid patterns.
  • Analysis of the DNA extracted from the tissues revealed that there is a MEN1 germline mutation in exon 10 codon 527, and somatic mutation in exon 2 codon 32 in the pancreatic tumor, and one base pair deletion in exon 2 codon 79 in the pituitary adenoma.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Cholesterol. Granuloma, Foreign-Body / pathology. Multiple Endocrine Neoplasia Type 1 / pathology. Pancreas / pathology. Pancreatic Neoplasms / pathology. Pituitary Neoplasms / pathology


32. Ito FA, Jorge J, Vargas PA, Lopes MA: Histopathological findings of pleomorphic adenomas of the salivary glands. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E57-61
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  • [Title] Histopathological findings of pleomorphic adenomas of the salivary glands.
  • OBJECTIVES: To describe the histopathological features of pleomorphic adenoma (PA) with special reference to the epithelial and mesenchymal components.
  • The epithelial component was analyzed according to the presence of plasmacytoid, spindle, clear, squamous, basaloid, cubic, oncocytoid and mucous cells and the morphological pattern (trabecular, ductal, cystic and solid).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19179950.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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33. Jarzembowski J, Lloyd R, McKeever P: Type IV collagen immunostaining is a simple, reliable diagnostic tool for distinguishing between adenomatous and normal pituitary glands. Arch Pathol Lab Med; 2007 Jun;131(6):931-5
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  • CONTEXT: Pituitary adenomas are clinically diagnosed based on radiologic studies and/or secondary effects of hormone production.
  • However, not all adenomas secrete hormones, so performing a battery of stains is inefficient.
  • DESIGN: We immunostained 27 adenomas and 19 normal pituitaries.
  • RESULTS: Adenomas have less type IV collagen in their basement membranes, leading to sparser, trabecular staining in neoplasms versus a more rigid meshwork pattern in normal glands.
  • One might envision the stained fibers as maze walls--one can traverse medium-powered fields in an adenoma, but one hits dead ends and gets trapped in those of a normal gland.
  • Finding a single representative x10 field to be traversable was 97.5% sensitive and 96.5% specific for an adenoma.
  • CONCLUSIONS: Type IV collagen immunostaining is a simple and reliable method of diagnosing pituitary adenomas.
  • [MeSH-major] Adenoma / metabolism. Collagen Type IV / metabolism. Pituitary Gland / metabolism. Pituitary Neoplasms / metabolism

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  • (PMID = 17550321.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type IV; 0 / Reticulin
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34. Ito Y, Arai K, Ryushi, Nozawa, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Kakudo K, Miyauchi A: S100A9 expression is significantly linked to dedifferentiation of thyroid carcinoma. Pathol Res Pract; 2005;201(8-9):551-6
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  • S100A9 was absent in normal follicles, follicular adenoma, and follicular and papillary carcinomas with conventional growth structures.
  • In lesions showing a solid, trabecular, or scirrhous growth pattern, S100A9 immunoreacitivity was occasionally observed.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. Calgranulin B / metabolism. Carcinoma, Papillary / metabolism. Cell Transformation, Neoplastic / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 16259107.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calgranulin B
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35. Okamoto T, Iihara M, Obara T, Tsukada T: Parathyroid carcinoma: etiology, diagnosis, and treatment. World J Surg; 2009 Nov;33(11):2343-54
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  • The distinction between unequivocal and equivocal carcinoma (or atypical adenoma) was not always made for the study populations.
  • Of the histopathological features described in the literature based on the description of Schantz and Castleman, capsular/vascular invasions and trabecular growth pattern were the most specific, and fibrous bands were the most sensitive.
  • None of the patients with "atypical adenoma" developed recurrence, whereas 25% of those with "equivocal carcinoma" did.
  • [MeSH-minor] Adenoma. Humans. Mutation. Odds Ratio. Prognosis. Risk Factors. Sensitivity and Specificity. Survival Analysis

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  • (PMID = 19350316.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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36. Cetani F, Pardi E, Ambrogini E, Banti C, Viacava P, Borsari S, Bilezikian JP, Pinchera A, Marcocci C: Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment. J Endocrinol Invest; 2008 Oct;31(10):900-4
SciCrunch. KEGG: Data: Disease Annotation .

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  • HRPT2 and parafibromin studies improved the diagnostic accuracy in two patients with primary hyperparathyroidism (PHPT) referred to us after surgery, in whom the clinical data were at variance with the pathological diagnosis of adenoma and carcinoma, respectively.
  • Patient #2, with severe PHPT, had had the removal of a 3.5-cm tumor described histologically as adenoma.
  • Re-review of the initial histology showed a trabecular pattern, fibrous bands, and atypical mitoses, suggesting an atypical adenoma.
  • Because of the suspicion that case #1 could be an atypical adenoma and case #2 a carcinoma further molecular studies were performed.
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Carcinoma / genetics. Carcinoma / pathology. Humans. Male. Middle Aged

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  • (PMID = 19092296.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK032333
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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37. Tuppurainen K, Mäkinen JM, Junttila O, Liakka A, Kyllönen AP, Tuominen H, Karttunen TJ, Mäkinen MJ: Morphology and microsatellite instability in sporadic serrated and non-serrated colorectal cancer. J Pathol; 2005 Nov;207(3):285-94
MedlinePlus Health Information. consumer health - Colorectal Cancer.

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  • Colorectal serrated adenocarcinoma originates from serrated adenoma, but definite histological criteria have not yet been established.
  • Serrated carcinomas frequently showed a serrated, mucinous or trabecular growth pattern; abundant eosinophilic cytoplasm; chromatin condensation; preserved polarity; and the absence of necrosis.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenoma / genetics. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Base Pair Mismatch / genetics. Biomarkers, Tumor / genetics. Carrier Proteins / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Colon / pathology. DNA, Neoplasm / genetics. Eosinophils / pathology. Female. Humans. Immunohistochemistry / methods. Male. Middle Aged. Neoplasm Proteins / genetics. Nuclear Proteins / genetics. Observer Variation. Rectum / pathology

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  • [Copyright] Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 16177963.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins
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38. Ghossein RA, Hiltzik DH, Carlson DL, Patel S, Shaha A, Shah JP, Tuttle RM, Singh B: Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: a clinicopathologic study of 50 cases. Cancer; 2006 Apr 15;106(8):1669-76
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  • In univariate analysis, > or = 4 foci of vascular invasion (P <.0001), tumor size > 4 cm (P = .049), the presence of mitosis (P = .018), and a solid/trabecular growth pattern (P = .009) were found to be correlated with a decreased RFS.
  • The finding of a solid/trabecular growth and mitosis correlated with the presence of numerous foci (> or = 4) of vascular invasion (P = .01 and P = .005, respectively).
  • CONCLUSIONS: A diligent search for vascular invasion is recommended in EHC that display mitosis or a solid/trabecular growth pattern.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / secondary. Neoplasm Recurrence, Local. Thyroid Neoplasms / pathology

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  • [Copyright] 2006 American Cancer Society
  • (PMID = 16534796.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Zhou CX, Gao Y: Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. Oral Oncol; 2009 Dec;45(12):e232-8
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  • The oncocytes were arranged in solid sheets, trabecular or duct-like structures.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Antibodies, Antinuclear / metabolism. Antibodies, Monoclonal / metabolism. Palatal Neoplasms / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19796983.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody; 0 / Neoplasm Proteins
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40. Sugihara A, Nakasho K, Ikuta S, Aihara T, Kawai T, Iida H, Yoshie H, Yasui C, Mitsunobu M, Kishi K, Mori T, Yamada N, Yamanegi K, Ohyama H, Terada N, Ohike N, Morohoshi T, Yamanaka N: Oncocytic non-functioning endocrine tumor of the pancreas. Pathol Int; 2006 Dec;56(12):755-9
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  • Tumor cells were arranged in a ribbon-like or trabecular pattern and had an abundant eosinophilic cytoplasm containing numerous mitochondria and neurosecretory granules.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17096734.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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41. de Matos PS, Ferreira AP, de Oliveira Facuri F, Assumpção LV, Metze K, Ward LS: Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy. Histopathology; 2005 Oct;47(4):391-401
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  • METHODS AND RESULTS: We evaluated 170 thyroid lesions including 148 neoplastic lesions [84 papillary carcinomas (PC), 38 follicular carcinomas (FC), 18 follicular adenomas, one hyalinizing trabecular tumour, five medullary carcinomas, two anaplastic carcinomas] and 22 non-neoplastic lesions (12 adenomatous nodules and 10 Hashimoto's thyroiditis).
  • Although the most helpful marker in terms of sensitivity and specificity for the follicular variant of PC and for FC diagnosis was HBME-1, when we consider the differentiation between cases of follicular variant of papillary carcinoma (FVPC) and FC or adenoma, in terms of percentage of positive cells, galectin-3 and CK 19 were more relevant.

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  • (PMID = 16178894.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / HBME-1 antigen; 68238-35-7 / Keratins
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42. Drebber U, Dienes HP: [Diagnosis and differential diagnosis of hepatocellular carcinoma]. Pathologe; 2006 Jul;27(4):294-9
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  • According to WHO guidelines, HCC encompasses the following: trabecular, pseudoglandular, acinar, compact, scirrhous and fibrolamellar subtypes.
  • Differential diagnosis has to be considered for such hepatic tumors as adenoma and precancerous lesions such as dysplastic nodules or mesenchymal tumors.

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  • (PMID = 16767425.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 26
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43. Carnevale V, Romagnoli E, Pipino M, Scillitani A, D'Erasmo E, Minisola S, Mazzuoli G: [Primary hyperparathyroidism]. Clin Ter; 2005 Sep-Oct;156(5):211-26
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  • Primary hyperparathyroidism (PHPT) is characterized by excessive PTH secretion in respect to calcium homeostasis needs, due to parathyroid adenoma (80% of cases), hyperplasia (15-20%), or carcinoma (1-2%).
  • Etiology of sporadic adenomas (80% of PHPT cases) is less defined, being most commonly found a mutation of menin gene or activation of PRAD1 oncogene.
  • Prominently trabecular skeletal sites are relatively spared, because of the anabolic effects of a slight PTH excess on trabecular tissue.

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  • (PMID = 16382970.001).
  • [ISSN] 0009-9074
  • [Journal-full-title] La Clinica terapeutica
  • [ISO-abbreviation] Clin Ter
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  • [Number-of-references] 100
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