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1. Min KW, Seo IS, Pitha J: Ossifying fibromyxoid tumor: modified myoepithelial cell tumor? Report of three cases with immunohistochemical and electron microscopic studies. Ultrastruct Pathol; 2005 Nov-Dec;29(6):535-48
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  • [Title] Ossifying fibromyxoid tumor: modified myoepithelial cell tumor? Report of three cases with immunohistochemical and electron microscopic studies.
  • Ossifying fibromyxoid tumors (OFMT) are rare soft tissue tumors of uncertain histogenesis and clinical behavior.
  • Three examples of soft tissue tumors with typical histopathologic characteristics of OFMT were studied: case 1, a 43-year-old female with a 2.5-cm tumor of the back; case 2, a 56-year-old man with an 8-cm thigh mass; and case 3, an 81-year-old female with a 13.5-cm buttock tumor.
  • For immunohistochemistry, formalin-fixed, paraffin-embedded tissue sections were stained with antibodies against cytokeratin, smooth muscle actin, desmin, vimentin, S-100 protein, EMA, and collagen type IV using standard ABC-peroxidase methods.
  • Immunohistochemistry showed that the tumor cells were positive for vimentin and S-100 protein in all 3 cases.
  • Stains for collagen type IV revealed diffusely positive staining in the stroma with a tendency for stronger staining around the cell borders in 2 out of 3 cases.
  • By electron microscopy, tumor cells were characterized by centrally located round to oval nuclei with varying amounts of cytoplasm containing scanty cytoplasmic organelles.
  • In case 3, which behaved as a malignant tumor, the tumor cells were less differentiated spindle cells with primitive cellular features, and EL was rarely found along the short span of tumor cell borders.
  • In this study, tumor cells in OFMT were polygonal to stellate often with multiple short cytoplasmic processes.
  • The tumor cells were found to form cell clusters attached by primitive intercellular junctions between cytoplasmic processes forming intercellular bridges.
  • These ultrastructural findings together with immunophenotypic expression of S-100 protein presented closer resemblance to those of modified myoepithelial cells in pleomorphic adenomas of salivary glands and skin appendages rather than peripheral nerve sheath tumors.
  • [MeSH-minor] Adult. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16316954.001).
  • [ISSN] 0191-3123
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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2. Koriyama N, Nishimoto K, Kodama T, Nakazaki M, Kurono Y, Yoshida H, Tei C: Oncogenic osteomalacia in a case with a maxillary sinus mesenchymal tumor. Am J Med Sci; 2006 Sep;332(3):142-7
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  • [Title] Oncogenic osteomalacia in a case with a maxillary sinus mesenchymal tumor.
  • We herein describe the rare case of a 41-year-old woman with oncogenic osteomalacia due to a tumor in the maxillary sinus who presented with chronic general pain that had been gradually deteriorating.
  • The causative tumor was surgically removed, resulting in a rapid resolution of the patient's biochemical abnormalities.
  • The pathologic diagnosis of the tumor was a "phosphaturic mesenchymal tumor, mixed with a connective tissue variant."
  • The expression of FGF23 was demonstrated in the tumor by the immunohistochemical techniques and a Western analysis.

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  • (PMID = 16969146.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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3. Santini D, Vincenzi B, Fratto ME, Perrone G, Lai R, Catalano V, Cass C, Ruffini PA, Spoto C, Muretto P, Rizzo S, Muda AO, Mackey JR, Russo A, Tonini G, Graziano F: Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer. J Cell Physiol; 2010 May;223(2):384-8
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  • We investigated the immunohistochemical expression of hENT in tumor samples from 111 patients with resected gastric adenocarcinoma, correlating these data with clinical parameters and disease outcomes.
  • On univariate survival analysis, the hENT1 expression was associated with overall survival (OS) and disease free survival (DFS).
  • Furthermore, considering only patients with diffuse or mixed tumors and lymph-node positive, the expression of hENT1 was strongly related with DFS and OS.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Equilibrative Nucleoside Transporter 1 / metabolism. Gastric Mucosa / metabolism. Stomach Neoplasms / diagnosis. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / metabolism. Antineoplastic Agents / pharmacokinetics. Cohort Studies. Disease Progression. Disease-Free Survival. Drug Resistance, Neoplasm / physiology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Metastasis / physiopathology. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / prevention & control. Predictive Value of Tests. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 20082300.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Equilibrative Nucleoside Transporter 1; 0 / SLC29A1 protein, human
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4. García-Galvis OF, Cabrera-Ozoria C, Fernández JA, Stolnicu S, Nogales FF: Malignant Müllerian mixed tumor of the ovary associated with yolk sac tumor, neuroepithelial and trophoblastic differentiation (teratoid carcinosarcoma). Int J Gynecol Pathol; 2008 Oct;27(4):515-20
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  • [Title] Malignant Müllerian mixed tumor of the ovary associated with yolk sac tumor, neuroepithelial and trophoblastic differentiation (teratoid carcinosarcoma).
  • This paper reports a unique stage IV complex ovarian carcinosarcoma in a 69-year patient that had malignant mixed müllerian epithelial and mesenchymal components and also other malignant differentiation such as neuroectodermal (small cell, neuroendocrine, neuroglial, neuronal, and melanocytic) and endodermal (yolk sac tumor) tissues and trophoblastic cells.
  • As its phenotype comprised elements derived embryologically from the 3 germ layers, it posed the problem of differentiating it from a teratoma originated from germ cells, with which it shared a trilaminar type differentiation.
  • It was different from a teratoma as it coexisted with, and possibly originated from, a somatic tumor, namely a characteristic endometrioid adenocarcinoma.
  • [MeSH-major] Carcinosarcoma / pathology. Endodermal Sinus Tumor / pathology. Mixed Tumor, Mullerian / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 18753971.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Indo H, Suenaga S, Nozoe E, Nakamura N, Tanuma J, Semba I, Majima HJ: Pleomorphic adenoma presenting low T2 signal-intensity on magnetic resonance imaging. Dentomaxillofac Radiol; 2006 Sep;35(5):380-2
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  • [Title] Pleomorphic adenoma presenting low T2 signal-intensity on magnetic resonance imaging.
  • We report an unusual case of pleomorphic adenoma of the submandibular gland in a 48-year-old female.
  • To our knowledge, the MR feature of low T(2) signal-intensity of pleomorphic adenoma has not been reported in the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 16940488.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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6. Hu X, Huang G, Jiang L, Song Q, Yao L, Qiao X: [Submandibular sialoadenectomy by a modified retroauricular approach]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2010 Aug;24(8):930-2
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  • METHODS: Between October 2008 and April 2009, 8 patients with benign submandibular gland disorders underwent removal of benign submandibular gland lesions using a retroauricular approach.
  • There were 4 males and 4 females with an average age of 38.5 years (range, 32-54 years), including 3 pleomorphic adenoma and 5 chronic sialadenitis with sialolithiasis.
  • The disease duration was from 2 months to 5 years.
  • The anterior facial vein and the facial artery were reserved only by the ligation of branching vessels in the submandibular gland.
  • [MeSH-major] Oral Surgical Procedures / methods. Salivary Gland Calculi / surgery. Submandibular Gland Diseases / surgery. Submandibular Gland Neoplasms / surgery

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  • (PMID = 20839438.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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7. Orita Y, Hamaya K, Miki K, Sugaya A, Hirai M, Nakai K, Nose S, Yoshino T: Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland. Eur Arch Otorhinolaryngol; 2010 May;267(5):801-6
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  • [Title] Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland.
  • The occasional local recurrence of benign pleomorphic adenoma (PA) has generally been attributed to the vulnerability of the tumor capsule.
  • Although some reports have also noted the presence of satellite tumors associated with PA recurrence, only few reports have focused on this issue.
  • We paid special attention to the satellite lesions apart from the main tumors and discussed their frequency, origin, nature and the ways of treating them.
  • A total of 108 specimens of primary parotid gland PA resected at the Okayama Saiseikai General Hospital from 1988 to 2008 were microscopically reviewed.
  • Four (3.7%) patients displayed a main mass with satellite tumors in a single parotid gland.
  • The immunohistochemical analysis of p53 and Ki-67 index showed no distinct difference between PAs with satellite tumors and those without.
  • Satellite tumors surrounding the main mass of parotid PA is relatively rare.
  • In most cases, such satellite tumors will arise from capsular perforation of the primary tumor cells.
  • Preoperative evaluation to recognize the existence of satellite tumors would be important and capsular dissection should be discouraged.
  • We could not find any evidence suggesting that primary PA with satellite tumors could be more biologically aggressive than those without.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19898859.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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8. Ungari C, Paparo F, Colangeli W, Iannetti G: Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms. Eur Rev Med Pharmacol Sci; 2008 Sep-Oct;12(5):321-5
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  • [Title] Parotid glands tumours: overview of a 10-year experience with 282 patients, focusing on 231 benign epithelial neoplasms.
  • Salivary gland tumours are uncommon, representing less than 6% of head and neck neoplasm.
  • Pleomorphic adenoma is the most common benign epithelial salivary gland neoplasm, comprising 50%-74% of all parotid tumours.
  • It is followed by Warthin's tumour (4-14%).
  • The authors retrospectively reviewed 282 eligible patients surgically treated for parotid gland tumours in the last 10 years, focusing on 231 benign epithelial neoplasms.
  • The diagnosis of a parotid gland neoplasm must be considered in any patient presenting with a lump near the mandible.
  • Smoking habit is important in Warthin's tumour pathogenesis.
  • Tumour pseudopodia and capsule ruptures are recognised factors involved in pleomorphic adenoma recurrences but also tumour multicentricity might play an important role.

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  • (PMID = 19024217.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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9. Erdélyi I, van Asten AJ, van Dijk JE, Nederbragt H: Expression of versican in relation to chondrogenesis-related extracellular matrix components in canine mammary tumors. Histochem Cell Biol; 2005 Aug;124(2):139-49
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  • [Title] Expression of versican in relation to chondrogenesis-related extracellular matrix components in canine mammary tumors.
  • Versican plays a role in tumor cell proliferation and adhesion and may also regulate cell phenotype.
  • We have previously demonstrated accumulation of versican protein in myoepithelial-like spindle cell proliferations and myxoid tissues of complex and mixed mammary tumors of dogs.
  • Therefore, we aimed to identify cartilage markers, such as collagen type II and aggrecan both at mRNA and protein level in relation to versican.
  • RT-PCR revealed upregulation of genes of versican, collagen type II and aggrecan in neoplastic tissues, especially in complex and mixed tumors.
  • Immunohistochemistry showed the expression of cartilage biomarkers not only in the cartilagenous tissues of mixed tumors, but also in myoepitheliomas and in the myoepithelial-like cell proliferations and myxoid areas of complex and mixed tumors.
  • The results show the cartilagenous differentiation of complex tumors and myoepitheliomas and indicate that the myxoid tissues and myoepithelial-like cell proliferations are the precursor tissues of the ectopic cartilage in mixed tumors.
  • Furthermore, we suggest that cartilage formation in canine mammary tumors is a result of (myo)epithelial to mesenchymal transition.
  • [MeSH-minor] Aggrecans. Animals. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Chondroitin Sulfates / genetics. Chondroitin Sulfates / metabolism. Collagen Type II / genetics. Collagen Type II / metabolism. Dogs. Extracellular Matrix Proteins / genetics. Extracellular Matrix Proteins / metabolism. Female. Gene Expression Regulation, Neoplastic. Lectins, C-Type. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Up-Regulation. Versicans

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  • (PMID = 16088379.001).
  • [ISSN] 0948-6143
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aggrecans; 0 / Biomarkers, Tumor; 0 / Chondroitin Sulfate Proteoglycans; 0 / Collagen Type II; 0 / Extracellular Matrix Proteins; 0 / Lectins, C-Type; 0 / Proteoglycans; 0 / RNA, Messenger; 126968-45-4 / Versicans; 9007-28-7 / Chondroitin Sulfates
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10. Silvoniemi A, Pulkkinen J, Grénman R: Parotidectomy in the treatment of pleomorphic adenoma -- analysis of long-term results. Acta Otolaryngol; 2010 Nov;130(11):1300-5
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  • [Title] Parotidectomy in the treatment of pleomorphic adenoma -- analysis of long-term results.
  • CONCLUSION: Parotidectomy is an efficient surgical treatment modality for pleomorphic adenoma of the parotid gland, although some morbidity may occur.
  • In this study, the median time interval between primary surgery and the presentation of the recurrent tumor was observed to be 14.4 years.
  • OBJECTIVE: Analysis of the long-term results of patients undergoing lateral or total parotidectomy as first-line treatment of parotid pleomorphic adenoma at our institution between the years 1979 and 1996.
  • A recurrent tumor occurred in nine cases (3.9%).
  • Recurrent tumors were treated with surgery, two patients received additional radiotherapy.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Neoplasm Recurrence, Local / epidemiology. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Causality. Child. Comorbidity. Digestive System Surgical Procedures / adverse effects. Digestive System Surgical Procedures / statistics & numerical data. Facial Paralysis / epidemiology. Facial Paralysis / etiology. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Parotid Gland / surgery. Radiotherapy, Adjuvant. Retrospective Studies. Sweating, Gustatory / epidemiology. Treatment Outcome. Young Adult

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  • (PMID = 20528201.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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11. Ogawa R, Mitsuhashi K, Oki K, Hyakusoku H: A rare case of chondroid syringoma arising from the lower eyelid with ectropion. Plast Reconstr Surg; 2006 Nov;118(6):137e-140e
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  • [Title] A rare case of chondroid syringoma arising from the lower eyelid with ectropion.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eyelids. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17051093.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Ide F, Mishima K, Yamada H, Saito I: Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland. Head Neck Pathol; 2009 Jun;3(2):159-62
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  • [Title] Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland.
  • There is a considerable variation in the histologic subtype of epithelial malignancies among carcinoma ex pleomorphic adenomas (CXPA) and virtually any known carcinoma entity can develop.
  • To our knowledge, adenoid cystic carcinoma (AdCC) ex PA is quite rare despite the fact that de novo AdCC is the fourth most common salivary gland malignancy.
  • We describe a new case of AdCC ex PA in the parotid gland of a 62 year-old woman.
  • Although most of the reported cases are considered low-grade, evidence is presented here that AdCC can take the form of a high-grade malignancy in PA.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology

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  • [Cites] Acta Otolaryngol. 1968 Dec;66(6):477-92 [4308066.001]
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  • (PMID = 19644550.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Carcinoma ex pleomorphic adenoma / High-grade malignancy / Parotid gland
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13. Obara K, Ide F, Mishima K, Inoue H, Yamada H, Hayashi Y, Saito I: Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis. Pathobiology; 2006;73(5):261-70
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  • [Title] Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis.
  • OBJECTIVE: To understand the salivary gland pathobiology, we established an immortalized duct/basal cell line (MSE) from the submandibular glands of p53-deficient mice.
  • RESULTS: Inoculation of a mixture of MSE and Matrigel reconstructed polarized ducts whereas cotransplantation of MSE with both Matrigel and NIH3T3 (3T3) cells developed mixed tumors of adenoma and sarcoma.
  • A daughter adenoma line (MSA) showed some transformed phenotype in vitro, but was marginally tumorigenic in vivo.
  • Notably, pleomorphic adenoma gene 1 (PLAG1) was expressed in MSA but not in MSE.
  • CONCLUSION: The intrinsic tumorigenic programs of p53 null salivary epithelium are promoted by 3T3 sarcoma-derived IGF-IIin a paracrine manner through overexpression of PLAG1 and IGF-IR.
  • [MeSH-major] Cell Communication / physiology. Cell Transformation, Neoplastic / metabolism. Epithelial Cells / metabolism. Salivary Glands / metabolism. Stromal Cells / metabolism. Tumor Suppressor Protein p53 / deficiency
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Animals. Blotting, Western. Cell Line. Collagen. DNA-Binding Proteins / metabolism. Drug Combinations. Female. Immunohistochemistry. Laminin. Mice. Mice, Transgenic. Microscopy, Electron, Transmission. Neoplasms, Experimental / metabolism. Neoplasms, Experimental / pathology. Proteoglycans. Receptor, IGF Type 1 / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology. Sarcoma / metabolism. Sarcoma / pathology

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 17314497.001).
  • [ISSN] 1015-2008
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Drug Combinations; 0 / Laminin; 0 / Plag1 protein, mouse; 0 / Proteoglycans; 0 / Tumor Suppressor Protein p53; 119978-18-6 / matrigel; 9007-34-5 / Collagen; EC 2.7.10.1 / Receptor, IGF Type 1
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14. Ikeda K, Tate G, Suzuki T, Mitsuya T: Effusion cytodiagnosis of carcinosarcoma derived from the female genital tract: immunohistochemical features of MMP-7 and Ki-67 and immunofluorescence double staining analyses of eight cases. Gynecol Oncol; 2005 May;97(2):323-9
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  • CONCLUSIONS: This is the first study to examine carcinosarcoma of the female reproductive organ by immunohistochemical staining for multiple antigens, which allows analysis of mixed tumor elements.

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  • (PMID = 15863125.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; EC 3.4.24.23 / Matrix Metalloproteinase 7
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15. Pagni F, Fuertes Zàrate A, Ren S: Neural invasion in pleomorphic adenoma of the salivary gland. Int J Surg Pathol; 2010 Apr;18(2):151-2
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  • [Title] Neural invasion in pleomorphic adenoma of the salivary gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasms, Second Primary / pathology. Peripheral Nerves / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 19948638.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Ayadi L, Chaâbouni S, Dhouib H, Abbès K, Dhouib M, Makni S, Abdelmoula M, Ghorbel A, Khabir A, Boudawara T: [Polymorphous low-grade adenocarcinoma: about two cases]. Tunis Med; 2009 Jun;87(6):403-6
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  • [Transliterated title] Adénocarcinome polymorphe de bas grade: à propos de deux cas.
  • BACKGROUND: Polymorphous low-grade adenocarcinoma (APBG) is a variant of malignant tumour of minor salivary glands usually arising in the palate.
  • AIM: Our aim is to discuss morphology, evolution and differential diagnosis of this rare tumour.
  • CASE REPORTS: The first case interested a 65-year-old-woman admitted for a two-months-history of a right submaxillary swelling.
  • Examination found a tumour of the right side of the palate.
  • A biopsy concluded to a pleomorphic adenoma.
  • The second case interested a 57-year-old-woman who consulted for a 12-year-history of a swelling of the lower lip.
  • The patient had no evidence of disease with a follow-up of 54 months.
  • CONCLUSION: APBG is characterised by a morphologic diversity and a cytologic uniformity that may cause a diagnostic dilemma especially with adenoid cystic carcinoma and pleomorphic adenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor


17. Olejniczak I, Kozłowski Z, Dabrowska K, Lukomski M: [Tumors of the parotid gland--management and results of surgical treatment]. Otolaryngol Pol; 2008;62(4):446-50
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  • [Title] [Tumors of the parotid gland--management and results of surgical treatment].
  • INTRODUCTION: Tumors of the salivary glands are uncommon and represent 2-4% of head and neck neoplasms.
  • Most tumors originate in the parotid gland, from which 10 to 15% are found to be malignant.
  • Different methods of surgical treatment can be performed depending on the type, localization and size of tumor.
  • MATERIAL AND METHODS: Retrospective analysis of the medical data of 138 patients with parotid gland tumors who where treated in our departament between 1997-2007 was done.
  • Benign tumors were found in 104 patients with the pleomorphic adenoma as the most common (53 cases).
  • The rest histological type were Whartin's tumor, myoepithelial and basal cell adenoma respectively.
  • The most frequent localization of the tumor after dividing the parotid gland into four parts was postero-inferior pole.
  • CONCLUSIONS: Frequency of tumors of the parotid gland, their histological types and methods of surgical treatment in our data support other studies.
  • Ultrasonography is the key procedure in the diagnosis of tumors of the parotid gland, qualification into surgical treatment and postoperative observation.
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / ultrasonography. Adult. Aged. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / ultrasonography. Female. Humans. Male. Middle Aged. Myoepithelioma / epidemiology. Myoepithelioma / ultrasonography. Poland. Retrospective Studies. Risk Factors. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 18837221.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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18. Abdollahi A: LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions. J Cell Physiol; 2007 Jan;210(1):16-25
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  • LOT1 is a target of growth factor signaling pathway(s) and silenced by epigenetic mechanisms, as well as by the loss of heterozygosity in different tumor tissues.
  • PLAG1 is a protooncogene that is localized on chromosome 8q12 and was found to be a target of several types of chromosomal rearrangement including the one identified in pleomorphic adenomas of the salivary gland.
  • [MeSH-major] Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Transformation, Neoplastic. Gene Expression Regulation, Developmental. Gene Expression Regulation, Neoplastic. Transcription Factors / genetics. Transcription Factors / metabolism. Transcription, Genetic. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism

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  • (PMID = 17063461.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human; 0 / PLAGL1 protein, human; 0 / PLAGL2 protein, human; 0 / RNA-Binding Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
  • [Number-of-references] 87
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19. Meer S, Altini M: CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology; 2007 Jul;51(1):26-32
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  • [Title] CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia.
  • AIMS: To evaluate cytokeratin (CK) 7/20 expression patterns in salivary gland neoplasia.
  • METHODS AND RESULTS: Formalin-fixed paraffin embedded tissue from 153 salivary gland tumours were evaluated for CK7/20 immunoreactivity.
  • The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepidermoid carcinoma (n = 21), polymorphous low-grade adenocarcinoma (n = 21), carcinoma ex-pleomorphic adenoma (n = 11), acinic cell carcinoma (n = 17), epimyoepithelial carcinoma (n = 7), oncocytic carcinoma (n = 3), hyalinizing clear cell carcinoma (n = 1), papillary cystadenocarcinoma (n = 1), salivary duct carcinoma (n = 3), adenocarcinoma (not otherwise specified) (n = 4) and squamous carcinoma (n = 4).
  • The results were expressed semiquantitatively, according to the estimated percentage of positive tumour cells: 1+, 5-25%; 2+, 26-75%; and 3+, 76-100%.
  • All salivary gland neoplasms showed a CK7+/CK20- immunoprofile ranging from 5 to 100%.
  • CONCLUSIONS: Although the CK7/20 immunoprofile is not useful in distinguishing the various types of salivary gland neoplasms or between benign and malignant salivary gland tumours, it may facilitate differentiation of primary salivary gland neoplasia from metastatic tumours and squamous carcinoma, and the diagnosis of metastatic salivary gland tumours.
  • [MeSH-major] Gene Expression Profiling. Keratin-20 / metabolism. Keratin-7 / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Salivary Glands / metabolism. Salivary Glands / pathology

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  • (PMID = 17593078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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20. Götte K, Ganssmann S, Affolter A, Schäfer C, Riedel F, Arens N, Finger S, Hörmann K: Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses. Oncol Rep; 2005 Nov;14(5):1103-7
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  • [Title] Dual FISH analysis of benign and malignant tumors of the salivary glands and paranasal sinuses.
  • To date, the underlying genomic changes in benign and malignant tumors of salivary-gland and paranasal-sinus origin are poorly understood.
  • This is due in part to the low incidence of these tumors and the enormous histological variety of tumors within this head and neck region.
  • We examined 58 of these tumors (14 adenoid cystic carcinomas, 9 adenocarcinomas, 5 cylindrical carcinomas, 11 pleomorphic adenomas, and 19 inverted papillomas) by dual fluorescence in situ hybridization (FISH) with centromere-specific probes on six chromosomes (3, 7, 9, 11, 17, and 18) for numerical changes.
  • In cylindrical cell carcinomas, polysomy of chromosomes 7, 9, 11 and 17 was present in the majority of tumors.
  • Disomy is rare, even in benign tumors.
  • Polysomy is more frequent in malignant tumors than in benign.
  • Tetrasomy is found almost only in malignant tumors.
  • In summary, the occurrence of polysomy might reflect a step towards malignancy in tumors of the salivary glands and paranasal mucosa.
  • Polysomy of chromosome 11 could be defined as typical for all investigated histological types of malignant tumor in this region of the head and neck.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / genetics. Adenoma / diagnosis. Adenoma / genetics. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / genetics. Chromosome Aberrations. Papilloma / diagnosis. Papilloma / genetics. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Diagnosis, Differential. Humans. In Situ Hybridization, Fluorescence. Salivary Gland Diseases / diagnosis. Salivary Gland Diseases / genetics

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  • (PMID = 16211271.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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21. Koyuncu M, Karagöz F, Kiliaçarslan H: Pleomorphic adenoma of the external auditory canal. Eur Arch Otorhinolaryngol; 2005 Dec;262(12):969-71
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  • [Title] Pleomorphic adenoma of the external auditory canal.
  • Pleomorphic adenoma of the external auditory canal is a rare disease.
  • The objective of this study is to familiarize the clinician with the clinical presentation and treatment of this disease.
  • We report the case of a 58-year-old woman.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ear Neoplasms / diagnosis. Ear, External / pathology

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  • [Cites] Laryngoscope. 1977 Oct;87(10 Pt 1):1601-12 [198620.001]
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  • (PMID = 15968569.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins; 68238-35-7 / Keratins
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22. Rizvi SA, Gupta Y, Gupta M: Surgical treatment and histopathological analysis of proptosis. Nepal J Ophthalmol; 2010 Jan-Jun;2(1):31-4
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  • INTRODUCTION: Inflammations and tumors of the orbit and para-orbital regions may present as proptosis.
  • According to location and type of tumour, different surgical options like anterior orbitotomy, lateral orbitotomy and medial orbitotomy were considered.
  • Primary orbital tumors were encountered in 15 cases (60%) and para-orbital in 10 (40%).
  • Of 15 primary orbital tumors, 7 (46.66%) were excised by lateral orbitotomy, another 7 (46.66%) were approached via anterior orbitotomy, whereas 1 (6.67%) was removed by medial orbitotomy.
  • Pediatric orbital tumors were quite common {7 (46.66%)}.
  • The most common benign adult tumor found in our study was pleomorphic adenoma of the lacrimal gland {3 (20%)}.
  • Proptosis due to primary orbital tumors is more common than para-orbital tumors.

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  • (PMID = 21141324.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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23. Iwai H, Yamashita T: Local excision procedure for Warthin's tumor of the parotid gland. Otolaryngol Head Neck Surg; 2005 Apr;132(4):577-80
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  • [Title] Local excision procedure for Warthin's tumor of the parotid gland.
  • The aim of this work is to establish a local excision procedure (LEP) and indications of this procedure for Warthin's tumor.
  • Seventy-three patients (82 sides) with Warthin's tumor were studied.
  • For Warthin's tumor estimated to be below the I-S line (Group A), LEP was used, involving resection of the tumor after locating and dissecting the marginal mandibular and colli branches.
  • For tumors not meeting these criteria (Group B), partial superficial parotidectomy was performed.
  • Conversely, no significant difference in tumor size or incidence of postoperative facial paresis was identified between the 2 groups.
  • In conclusion, LEP is useful for Warthin's tumor below the I-S line.
  • This procedure seems applicable not only to Warthin's tumors, but also to other benign parotid tumors in the surgical field below the I-S line, such as pleomorphic adenoma and lymphoepithelial cyst.
  • [MeSH-major] Adenolymphoma / surgery. Microsurgery / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 15806048.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Lai T, Prabhakaran VC, Malhotra R, Selva D: Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy? Eye (Lond); 2009 Jan;23(1):2-6
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  • [Title] Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy?
  • AIM: To review the literature on biopsy of lacrimal gland pleomorphic adenoma (LGPA) and to examine the validity of the prohibition against biopsy in LGPA.
  • On the basis of a detailed examination of the literature on biopsy of both LGPA and pleomorphic adenoma of the salivary glands, it appears that there is no clear evidence to support the claim that biopsy increases the risk of recurrence or of malignant transformation of LGPA.
  • CONCLUSION: Lacrimal gland tumours are uncommon lesions and optimal management depends to a great extent on a definite preoperative diagnosis.
  • Preoperative biopsy should therefore be considered in all lacrimal gland mass lesions and management should be tailored to the biopsy findings.
  • If surgical resection is then required, it may be prudent to excise the biopsy tract to ensure complete removal of the tumour.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus / pathology. Lacrimal Apparatus Diseases / pathology

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  • [CommentIn] Eye (Lond). 2010 Feb;24(2):386 [19407844.001]
  • (PMID = 18327162.001).
  • [ISSN] 1476-5454
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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25. Gurey LE, Brook CD, Parnes SM: Pleomorphic adenoma of the infratemporal fossa: case report and literature review. Laryngoscope; 2010;120 Suppl 4:S151
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  • [Title] Pleomorphic adenoma of the infratemporal fossa: case report and literature review.
  • OBJECTIVES: To describe an unusual location for a common benign salivary gland neoplasm.
  • A complete PubMed search of atypical presentations of pleomorphic adenoma was performed.
  • RESULTS: Pleomorphic adenoma has been reported to arise in such diverse locations as the nasal septum, main stem bronchus, trachea, lacrimal gland and external auditory canal.
  • No cases of pleomorphic adenoma involving the infratemporal fossa have been reported.
  • Malignancies can often have an insidious presentation that is initially referred to other disease entities.
  • Patients with malignancies of this region usually present late in their disease course with invasion into surrounding structures.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Athletic Injuries / complications. Facial Injuries / complications. Skull Neoplasms / pathology. Temporal Bone / pathology

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  • (PMID = 21225749.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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26. Kunimura T: Noninvasive carcinoma ex pleomorphic adenoma of the parotid gland. Otolaryngol Head Neck Surg; 2007 Oct;137(4):687-8
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  • [Title] Noninvasive carcinoma ex pleomorphic adenoma of the parotid gland.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17903596.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Vageli D, Sourvinos G, Ioannou M, Koukoulis GK, Spandidos DA: High-risk human papillomavirus (HPV) in parotid lesions. Int J Biol Markers; 2007 Oct-Dec;22(4):239-44
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  • Although several studies have reported that oropharyngeal infection with HPV may predispose to tumorigenesis, little is known about the etiological factors of salivary gland tumors and the presence of HPV.
  • We studied 9 parotid lesions for HPV infection including an oncocytoma, an acinic cell carcinoma, a high-grade adenocarcinoma, a low-grade polymorphous adenocarcinoma, a Warthin's tumor and 2 pleomorphic adenomas, a lymphoepithelial cyst and a lipoma of the parotid gland.
  • Solution PCR for HPV detection was performed using the GP5+/GP6+ primers, while HPV typing was carried out by multiplex PCR for HPV6, 11, 16, 18, and 33; positive samples were recorfirmed by PCR with specific primers for each type.
  • High viral load of highrisk genotypes of HPV was found in the oncocytoma, in one of the pleomorphic adenomas, and in the Warthin's tumor.
  • Finally, in situ PCR indicated that HPV16 amplification occurred in the salivary gland tumors.
  • This is the first time that highrisk HPV genotypes are detected in these histological types of parotid lesions, suggesting the possible involvement of the virus in the disease.
  • [MeSH-major] Papillomaviridae / metabolism. Papillomavirus Infections / virology. Parotid Gland / pathology. Parotid Neoplasms / virology. Salivary Gland Neoplasms / virology

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  • [CommentIn] Int J Biol Markers. 2011 Oct-Dec;26(4):278-80 [22180174.001]
  • (PMID = 18161653.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Probes, HPV
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28. Kurokawa H, Yoshida M, Igawa K, Sakoda S: Extensive necrosis of pleomorphic adenoma in the soft palate: a case report and review of the literature. J Oral Maxillofac Surg; 2008 Apr;66(4):797-800
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  • [Title] Extensive necrosis of pleomorphic adenoma in the soft palate: a case report and review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Palatal Neoplasms / pathology. Palate, Soft / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 18355608.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 10
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29. Mărgăritescu C, Mercuţ V, Mogoantă L, Florescu M, Simionescu C, Cionca L, Manea M: Salivary gland Basal cell adenomas--immunohistochemical evaluation of four cases and review of the literature. Rom J Morphol Embryol; 2005;46(1):29-40
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  • [Title] Salivary gland Basal cell adenomas--immunohistochemical evaluation of four cases and review of the literature.
  • OBJECTIVE: Evaluate the antigen profile of cellular population from basal cell adenomas.
  • MATERIAL AND METHODS: Histopathological and immunohistochemical evaluation of four-salivary gland basal cell adenomas; the pathological samples were provided by the Oral Maxilla Facial Surgery Department of the Clinical County Hospital from Craiova.
  • RESULTS: All basal cell adenoma exhibit differentiation toward 3 cell phenotypes: ductal luminal, basal and myoepithelial.
  • CONCLUSIONS: The antigen profile of these tumors closely regard with other variants of salivary gland adenomas, such as pleomorphic adenoma and myoepithelioma.
  • So, we can conclude that these tumors had a common origin, most probably from intercalated ducts and the proportion of those 3 cellular types, their cytoarchitectural arrangements and the quantity of extracellular matrix production can do the differentiation between them.
  • [MeSH-major] Adenoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16286982.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen
  • [Number-of-references] 66
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30. McNamara ZJ, Batstone M, Farah CS: Carcinoma ex pleomorphic adenoma in a minor salivary gland of the upper lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Nov;108(5):e51-3
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  • [Title] Carcinoma ex pleomorphic adenoma in a minor salivary gland of the upper lip.
  • We present an exceedingly rare case of carcinoma ex pleomorphic adenoma (CXPA) arising in a minor salivary gland of the upper lip.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Lip Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19836713.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. do Prado RF, Consolaro A, Taveira LA: Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study. Med Oral Patol Oral Cir Bucal; 2006 May;11(3):E247-51
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  • [Title] Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study.
  • OBJECTIVES: Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common.
  • The objective of this study was to detect the expression of beta-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions.
  • STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands).
  • RESULTS: All cases of glands, adenomas and carcinomas in pleomorphic adenomas have membranous and cytoplasmic immunostaining.
  • Higher beta-catenin index rates were seen mainly in salivary gland ducts and in ductal structures in the adenomas and carcinomas in pleomorphic adenomas.
  • There was protein loss in pleomorphic adenomas and cytoplasmic accumulation in carcinoma in pleomorphic adenomas.
  • CONCLUSIONS: The present study showed participation of the loss of beta-catenin adhesion molecule in the development of pleomorphic adenoma, and that the cytoplasmic accumulation of the molecule takes part in the malignant transformation of the pleomorphic adenoma into carcinoma in pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Carcinoma / metabolism. Neoplasms, Multiple Primary / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Glands / metabolism. beta Catenin / biosynthesis

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  • (PMID = 16648762.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / beta Catenin
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32. Klijanienko J, Caillaud JM, Lagacé R: Cytohistologic correlations in schwannomas (neurilemmomas), including "ancient," cellular, and epithelioid variants. Diagn Cytopathol; 2006 Aug;34(8):517-22
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  • Schwannoma accounts for one of the most common benign mesenchymal neoplasms of soft tissues.
  • Original cytologic diagnosis was schwannoma in 13 (38.2%) cases, benign soft tissue tumor in 11 (32.4%), pleomorphic adenoma in 2 (6%) cases, angioma in 1 (2.9%) case, nodular fasciitis in 1 (2.9%) case, suspicious in 3 (8.8%) cases, and not satisfactory in 3 (8.8%) cases.
  • Schwannoma should be differentiated from well-differentiated malignant peripheral nerve sheath tumor, neurofibroma, and pleomorphic adenoma, in the last instance particularly for head and neck lesions.

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16850489.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Dessureault S, Alsarraj M, McCarthy S, Hunter T, Noyes D, Lee D, Harkins J, Seigne J, Jennings R, Antonia SJ: A GM-CSF/CD40L producing cell augments anti-tumor T cell responses. J Surg Res; 2005 May 15;125(2):173-81
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  • [Title] A GM-CSF/CD40L producing cell augments anti-tumor T cell responses.
  • BACKGROUND: Tumors evade T cell-mediated rejection despite the presence of tumor associated antigens (TAAs) and T cells specific for these TAAs in cancer patients.
  • Therapeutic tumor vaccines are being developed to prevent this evasion.
  • Previous reports revealed that anti-tumor T cell responses could be activated in mice when granulocyte macrophage-colony stimulating factor (GM-CSF) or CD40L are produced at tumor vaccine sites.
  • We sought to test the hypothesis that production of GM-CSF and CD40L by a bystander cell line could induce an anti-tumor T cell response in an in vitro human model.
  • The effect of this cell line on T cell responses was tested in a human autologous mixed tumor cell/lymph node cell model using tissue from a series of cancer patients.
  • RESULTS: There was no significant anti-tumor T cell response when human lymphocytes derived from tumor-draining lymph nodes were stimulated with autologous tumor cells in vitro.
  • However, significant anti-tumor T cell responses were observed when bystander cells transfected with CD40L and GM-CSF were added to the cultures.
  • CONCLUSIONS: A fully autologous human model consisting of tumor cells as stimulator cells and tumor-draining lymph nodes as responder cells can be used to test immunotherapeutic strategies.
  • T cells in these lymph nodes are unresponsive to autologous tumor cells, but this lack of responsiveness can be reversed in the presence of GM-CSF and CD40L.
  • These data provide a rationale for testing tumor cell vaccines incorporating GM-CSF- and CD40L-expressing bystanders in clinical trials.

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  • (PMID = 15854671.001).
  • [ISSN] 0022-4804
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cancer Vaccines; 147205-72-9 / CD40 Ligand; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
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34. Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, Casanova M, Mattavelli F, Scaramellini G: Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer; 2006 Nov;47(6):806-10
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  • [Title] Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan.
  • BACKGROUND: Epithelial salivary gland tumors are very uncommon in pediatric age.
  • These results are presented in conjunction with a literature review of salivary tumors with a view to providing an up-to-date overview of the clinical course, prognosis, and treatment options for this rare tumor.
  • PROCEDURE: Fifty-two cases of epithelial salivary tumors were reviewed and the clinical-pathological information concerning tumor characteristics, therapy, and follow-up were collected.
  • RESULTS: The major salivary glands were the main site of tumor occurrence (79% of cases arose in parotid glands); 37 patients had benign tumors (pleomorphic adenoma), 15 had malignant tumors (12 mucoepidermoid carcinoma, 9 low grade).
  • All the patients were treated by surgery; local relapses after parotidectomy were 4% and 25%, in benign and malignant tumors, respectively.
  • When tumor enucleation was performed, recurrences occurred in 50% of benign neoplasms.
  • At the time of the report, all patients with benign tumors were alive, 35(95%) without evidence of disease; only one patient with malignant tumor died of disease.
  • CONCLUSIONS: Epithelial salivary glands tumor in children had different characteristics compared with their adult counterpart with respect to the frequency of histotypes and site of occurrence, but their prognosis seems to be similar.
  • Parotidectomy (total or superficial) is the best choice for achieving good cure rates in both benign and malignant tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Carcinoma, Acinar Cell / surgery. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / surgery. Neoplasm Recurrence, Local / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Disease-Free Survival. European Continental Ancestry Group. Female. Follow-Up Studies. Humans. Italy. Male. Prognosis. Recurrence. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16425245.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Shikishima K, Kawai K, Kitahara K: Pathological evaluation of orbital tumours in Japan: analysis of a large case series and 1379 cases reported in the Japanese literature. Clin Exp Ophthalmol; 2006 Apr;34(3):239-44
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  • [Title] Pathological evaluation of orbital tumours in Japan: analysis of a large case series and 1379 cases reported in the Japanese literature.
  • The most common primary tumour was malignant lymphoma (12%) followed by pleomorphic adenoma (7%).
  • Pleomorphic adenomas in Japan were found to be much more common compared with that reported for American and European studies.

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  • (PMID = 16671904.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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36. Debnath SC, Saikia AK, Debnath A: Pleomorphic adenoma of the palate. J Maxillofac Oral Surg; 2010 Dec;9(4):420-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the palate.
  • Pleomorphic adenoma is a benign tumor of the salivary glands that has elements of both epithelial and mesenchymal tissues.
  • The tumor most commonly arises in the parotid or submandibular glands.
  • Infrequently, it may arise from the minor salivary glands and present as an intraoral mass over the palate or lip.

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  • (PMID = 22190837.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177488
  • [Keywords] NOTNLM ; Palate / Pleomorphic adenoma / Salivary gland
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37. Donati M, Gandolfo L, Privitera A, Brancato G, Cardi F, Donati A: Superficial parotidectomy as first choice for parotid tumours. Chir Ital; 2007 Jan-Feb;59(1):91-7
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  • Parotid neoplasms represent 3% of all head and neck tumours, and most are benign.
  • Sixteen patients presented with a history of a painless parotid lump.
  • At histology, 10 pleomorphic adenomas, 4 Warthin's tumours, 1 lymphoepithelial cyst and 1 sebaceous adenocarcinoma were detected.
  • The capsule appeared breached in only 1 case of pleomorphic adenoma.
  • A salivary fistula was recorded in 2 patients (13%).
  • During follow-up ranging from 3 to 96 months no tumour recurrence was recorded.
  • Superficial parotidectomy seems to be the best choice of treatment for benign parotid tumours, since it allows complete excision of the tumour with sparing of the facial nerve.
  • [MeSH-major] Parotid Neoplasms / surgery. Salivary Gland Fistula / surgery

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  • (PMID = 17361936.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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38. Lindsey KR, Gritz L, Sherry R, Abati A, Fetsch PA, Goldfeder LC, Gonzales MI, Zinnack KA, Rogers-Freezer L, Haworth L, Mavroukakis SA, White DE, Steinberg SM, Restifo NP, Panicali DL, Rosenberg SA, Topalian SL: Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma. Clin Cancer Res; 2006 Apr 15;12(8):2526-37
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  • Additional patients showed evidence of lesional regression (mixed tumor response) or overall regression that did not achieve partial response status (minor response).

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  • (PMID = 16638862.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 BC010763-01; United States / Intramural NIH HHS / / Z01 SC003811-32; United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / DNA, Recombinant; 0 / Immunoglobulin G; 0 / Interleukin-2; 0 / RNA, Messenger; 82115-62-6 / Interferon-gamma; EC 1.14.18.1 / Monophenol Monooxygenase
  • [Other-IDs] NLM/ NIHMS35505; NLM/ PMC2151202
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39. Hyer S, Kong A, Pratt B, Harmer C: Salivary gland toxicity after radioiodine therapy for thyroid cancer. Clin Oncol (R Coll Radiol); 2007 Feb;19(1):83-6
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  • [Title] Salivary gland toxicity after radioiodine therapy for thyroid cancer.
  • AIMS: Salivary gland toxicity is a common, but not widely appreciated, adverse effect of high-dose radioiodine (131I).
  • This study was carried out to determine the incidence of symptoms of salivary gland damage after 131I treatment for differentiated thyroid cancer.
  • Symptoms of salivary gland damage (dry mouth, pain and swelling) were assessed during hospital admission and at follow-up visits.
  • Additionally, a retrospective analysis was carried out of patients recorded in our database as having chronic salivary gland swelling after 131I ablation.
  • RESULTS: Twenty patients (26%) developed salivary gland toxicity, 11 (15%) had symptoms within the first 48 h, continuing for 12 months in seven of these patients.
  • After searching our thyroid cancer database, we identified an additional five patients to have chronic salivary gland swelling (chronic sialadenitis or pleomorphic adenoma) 20 months to 23 years after 131I.
  • Early recognition of salivary gland complications may help to reduce morbidity in these patients.
  • [MeSH-major] Adenoma / diagnostic imaging. Radiation Injuries / etiology. Salivary Glands / radiation effects. Thyroid Neoplasms / radiotherapy
  • [MeSH-minor] Adenoma, Oxyphilic / radiotherapy. Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Iodine Radioisotopes / adverse effects. Male. Middle Aged. Prospective Studies. Radiography. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome. Xerostomia / etiology

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  • (PMID = 17305259.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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40. Cavaliéri Gomes C, da Silveira e Oliveira C, Santos Pimenta LG, De Marco L, Santiago Gomez R: Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms. Pathobiology; 2009 May;76(3):136-40
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  • [Title] Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
  • OBJECTIVE: Salivary gland neoplasms pathogenesis has not been well established.
  • While DNMT3a is mostly involved in de novo methylation, DNMT1 acts as a maintenance methyltransferase.
  • We aimed to investigate the immunoexpression of DNMT3a and DNMT1 in minor salivary gland neoplasms, comparing it with normal tissue.
  • MATERIAL: Forty-four formalin-fixed and paraffin-embedded samples of pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma and polymorphous low-grade adenocarcinoma were included in the study.
  • Positive nuclear labeling for DNMT3a was found only in few neoplasms: 1 pleomorphic adenoma (9.0%), 2 adenoid cystic carcinoma (16.6%) and 1 mucoepidermoid (9.0%) cases.
  • CONCLUSION: Our results were not able to demonstrate a clear correlation between DNMT1 and DNMT3a immunoexpression and salivary gland neoplasms development.
  • [MeSH-major] DNA (Cytosine-5-)-Methyltransferase / biosynthesis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. DNA Methylation. Female. Humans. Immunohistochemistry. Male. Middle Aged. Salivary Glands, Minor / metabolism. Salivary Glands, Minor / pathology. Young Adult

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19468253.001).
  • [ISSN] 1423-0291
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37 / DNA (cytosine-5-)-methyltransferase 1; EC 2.1.1.37 / DNA methyltransferase 3A
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41. Laxmisha C, Thappa DM, Jayanthi S: Chondroid syringoma of the ear lobe. J Eur Acad Dermatol Venereol; 2007 Feb;21(2):276-7
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  • [Title] Chondroid syringoma of the ear lobe.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Carcinoma, Skin Appendage / diagnosis. Ear Neoplasms / diagnosis. Ear, External / pathology

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  • (PMID = 17243982.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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42. Bernardini FP, Devoto MH, Croxatto JO: Epithelial tumors of the lacrimal gland: an update. Curr Opin Ophthalmol; 2008 Sep;19(5):409-13
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  • [Title] Epithelial tumors of the lacrimal gland: an update.
  • PURPOSE OF REVIEW: The goal of this article is to offer an update on the treatment and prognosis of the most common epithelial tumors of the lacrimal gland, report on new pathological entities and offer a review of the classification of lacrimal gland tumors.
  • RECENT FINDINGS: Improvements have been made in the understanding of lacrimal gland lesions with the knowledge that lacrimal gland tumors compare to the more common counterparts of the major salivary glands.
  • Therefore, the WHO's classification of salivary gland tumors has been adapted to the lacrimal gland pathology.
  • Until recently, primary adenocarcinomas of the lacrimal gland were not further subclassified, but they can now be divided into low-grade and high-grade malignancies.
  • The adjunctive use of intra-arterial cytoreductive chemotherapy for the management of adenoid cystic carcinoma is one of the most important advancements on the management of these aggressive tumors.
  • Another important step forward has been taken on carcinoma ex pleomorphic adenoma of the lacrimal gland, which is subclassified into noninvasive carcinoma, with an excellent prognosis after complete excision and invasive carcinoma for which the prognosis is still guarded despite adjunctive radiotherapy.
  • SUMMARY: This article offers an update on diagnosis, classification and treatment of common and rare epithelial lacrimal gland tumors.

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  • (PMID = 18772674.001).
  • [ISSN] 1531-7021
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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43. Turhan-Haktanir N, Sahin O, Bukulmez A, Demir Y: Chondroid syringoma in a child. Pediatr Dermatol; 2007 Sep-Oct;24(5):505-7
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  • [Title] Chondroid syringoma in a child.
  • Chondroid syringoma is a myxoid tumor of the skin, which has a reported incidence of <0.01% among primary skin tumors.
  • The majority of these tumors occur in the head and neck regions of adult males.
  • We present the first instance of chondroid syringoma in a child, which, to the best of our knowledge, has not been reported previously in the English language literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Nose Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17958797.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Kazakov DV, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, Grossmann P, Michal M: Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol; 2009 May;31(3):248-55
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  • [Title] Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors.
  • Previous studies suggested that mutant beta-catenin gene cells in cutaneous adnexal tumors with matrical differentiation contribute to their tumorigenesis.
  • Except for pilomatricoma and pilomatrical carcinoma, only a handful of other cutaneous adnexal tumor types have been studied.
  • DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene.
  • These included 5 different point mutations, 3 of them identified in 2 different tumors: S23N (cribriform trichoblastoma), D32Y (pilomatricoma and craniopharyngioma), G34R (pilomatrical carcinoma and craniopharyngioma), S37F (2 BCCs with shadow cell differentiation), and G34V (craniopharyngioma).
  • This study broadens the list of cutaneous adnexal tumors harboring CTNNB1 mutations and extends the listing of the mutations occurring in these neoplasms.

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  • (PMID = 19384065.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
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45. Irving JA, McCluggage WG: Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis. Adv Anat Pathol; 2007 Sep;14(5):305-19
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  • The majority of ovarian spindle cell lesions fall into the broad category of fibromatous neoplasms whereas others in the sex cord-stromal group may also be composed of spindle cells, including thecomas, granulosa, and Sertoli-Leydig cell tumors and rarer neoplasms, such as sclerosing stromal tumor and signet-ring stromal tumor.
  • In the recent past there have been several major contributions on various aspects of ovarian spindle cell lesions, including cellular and mitotically active cellular fibromatous lesions, smooth muscle neoplasms, and metastatic gastrointestinal stromal tumors.
  • Other mesenchymal or epithelial tumors and mixed epithelial and mesenchymal neoplasms may also enter into the differential diagnosis of an ovarian spindle cell lesion.
  • Morphology remains the mainstay in diagnosis but immunohistochemistry may be invaluable in certain circumstances, one example being the identification of a metastatic gastrointestinal stromal tumor within the ovary.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Pathology, Surgical / methods. Pathology, Surgical / trends

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  • (PMID = 17717430.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 101
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46. Betka J, Chovanec M, Klozar J, Taudy M, Plzák J, Kodetová D, Lisý J: Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors. Eur Arch Otorhinolaryngol; 2010 May;267(5):765-72
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  • [Title] Transoral and combined transoral-transcervical approach in the surgery of parapharyngeal tumors.
  • The goal of parapharyngeal space (PPS) tumor surgery is to obtain adequate visualization to ensure complete removal with preservation of the surrounding nerves and vessels.
  • Transoral approach is the most controversial one due to cited limited exposure, risk of tumor spillage, and possibility of neurovascular injury.
  • We performed retrospective analysis of 26 consecutive patients who had undergone transoral or combined transoral-transcervical resection of PPS tumors from January 1997 to December 2007.
  • Both approaches were safely employed to remove selected PPS tumors.
  • Majority of treated tumors were pleomorphic adenomas (14 minor salivary gland and 7 deep lobe parotid gland tumors).
  • Two cases of malignant salivary gland tumors, 4 nerve sheath tumors and 1 lymphangioma were also excised.
  • Mean tumor size was 6.1 cm (range 2-11 cm).
  • Patients with malignant tumors had postoperative radiotherapy.
  • Radically treated cases are disease free.
  • One of the near-totally resected tumors needed revision surgery.
  • Transoral approach provides access to selected cases of PPS tumors based on preoperative imaging methods and fine-needle aspiration cytology.
  • It can be combined with external approach to achieve safe resection of some benign tumors which would need transmandibular approach.
  • [MeSH-minor] Female. Humans. Male. Mouth. Neck. Neoplasm Staging. Nerve Sheath Neoplasms / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 19714351.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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47. Zhang QQ, Song XC, Zhang H: [Resection of the pleomorphic adenoma in trachea by tracheotomy (Report of 2 cases).]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Dec;44(12):1039
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  • [Title] [Resection of the pleomorphic adenoma in trachea by tracheotomy (Report of 2 cases).].
  • [MeSH-major] Adenoma, Pleomorphic. Tracheotomy

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  • (PMID = 20193623.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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48. Hadj-Taieb I, Masmoudi A, Ayadi L, Meziou TJ, Khabir A, Charfeddine A, Boujelbène S, Beyrouti MI, Tahri N, Boudawara T, Turki H, Zahaf A: [Appendicular cystadenocarcinoma with cutaneous fistula]. Ann Dermatol Venereol; 2010 Mar;137(3):198-202
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  • We report a case of fistular lesions of the buttocks revealing a mixed tumour of the appendix involving mucinous cystadenocarcinoma and carcinoid tumour.
  • Histological examination of skin biopsy specimens identified infiltration of the dermis by metastatic mucinous adenocarcinoma while colonoscopy showed a caecal tumour measuring 4 cm.
  • Histopathological examination of surgical specimen confirmed mixed tumour consisting of perforated mucinous cystadenocarcinoma and carcinoid tumour of the appendix.
  • DISCUSSION: Cutaneous metastasis of colorectal cancer is an uncommon event that usually occurs after identification of the primary tumour and generally indicates advanced-stage disease and an ominous prognosis.
  • [MeSH-minor] Aged. Carcinoid Tumor / pathology. Female. Humans. Skin Neoplasms / secondary

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20227562.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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49. Méjean-Lebreton F, Barnoud R, de la Roche E, Devouassoux-Shisheboran M: [Benign salivary gland-type tumors of the bronchus: expression of high molecular weight cytokeratins]. Ann Pathol; 2006 Feb;26(1):30-4
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  • [Title] [Benign salivary gland-type tumors of the bronchus: expression of high molecular weight cytokeratins].
  • [Transliterated title] Adénomes bronchiques de type tumeurs des glandes salivaires: expression des cytokératines de haut poids moléculaire.
  • Primary lung tumors showing features of salivary gland-type neoplasms are extremely rare, and their immunohistochemical profile has been seldom studied.
  • We report two cases of bronchial pleomorphic and mucous gland adenomas and study the expression of markers such as TTF-1 and high molecular weight keratins in these tumors.
  • Both tumors were endobronchial.
  • The pleomorphic adenoma also had a well-circumscribed parenchymal component, with a biphasic morphology composed of epithelial and myoepithelial cells in a background of myxoid and hyaline stroma.
  • The mucous gland adenoma displayed papillary and dilated glandular structures.
  • This immunoprofile provides useful clues for the histogenesis of pulmonary benign salivary gland-type adenomas and helps in distinguishing them from primary adenocarcinomas in small biopsy specimens.
  • [MeSH-major] Bronchial Neoplasms / pathology. Keratins / analysis. Salivary Gland Neoplasms / pathology

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  • (PMID = 16841008.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 68238-35-7 / Keratins
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50. Auluck A, Pai KM: In reply: Pleomorphic adenoma with extensive necrosis report of two cases. Oral Diseases 2004; 10: 54-59. Oral Dis; 2005 May;11(3):194
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  • [Title] In reply: Pleomorphic adenoma with extensive necrosis report of two cases. Oral Diseases 2004; 10: 54-59.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Palate / pathology. Salivary Gland Neoplasms / pathology

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  • [CommentOn] Oral Dis. 2004 Jan;10(1):54-9 [14996296.001]
  • (PMID = 15888114.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Denmark
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51. Mensink HW, Mooy C, Paridaens D: In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Clin Exp Ophthalmol; 2005 Dec;33(6):669-71
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  • [Title] In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland.
  • A case of an in situ adenocarcinoma of the lacrimal gland that developed in a recurring pleomorphic adenoma is presented.
  • Six years after incomplete resection of a pleomorphic adenoma, the patient complained of a progressive swelling of her right upper eyelid without pain or diplopia.
  • An orbital computerized tomography scan showed an inhomogeneous mass in the right lacrimal gland region without bone involvement.
  • After local excision of the in situ adenocarcinoma ex pleomorphic adenoma, the tumour has been in control for over 6 years.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 16402969.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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52. Biernat W: Lipomatous mixed tumor of the skin. Am J Dermatopathol; 2008 Jun;30(3):284-6
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  • [Title] Lipomatous mixed tumor of the skin.
  • An unusual tumor of the neck in a 56-year-old female is reported.
  • The tumor was composed of tubules and small cords of epithelial cells dispersed in the fibromyxoid and adipose stroma.
  • At the periphery, the tumor was not encapsulated and its border was intermingled with the subcutaneous fat.
  • Lack of decapitation secretion and the absence of long tubules suggested an eccrine origin; however, in some of the tumor areas, the cells showed brightly eosinophilic copious cytoplasm that may indicate an apocrine differentiation.
  • As an area of chondroid metaplasia was identified, the diagnosis of a mixed tumor was rendered.
  • This unusual type of skin adnexal neoplasm with unique relation of the epithelial component to the surrounding adipose tissue requires differentiation with the primary cutaneous and metastatic carcinomas.
  • [MeSH-major] Adipose Tissue / pathology. Head and Neck Neoplasms / diagnosis. Lipoma / pathology. Neoplasms, Complex and Mixed / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged. Neoplasm Metastasis / diagnosis

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  • (PMID = 18496435.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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53. Zheng G, Yang YC: Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2. J Biol Chem; 2005 Dec 9;280(49):40773-81
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  • PLAG1 (pleomorphic adenoma gene 1) and PLAGL2 (PLAG-like 2) are oncogenes involved in various malignancies.
  • The repression mediated by sumoylation may be partially explained by its effect on the cellular localization of PLAG1 and PLAGL2, because sumoylation-deficient but not wild-type PLAG1 and PLAGL2 concentrate in the nucleolus.
  • Interestingly, the sumoylation-deficient mutant of PLAGL2 is acetylated at a lower level than its wild-type counterpart, suggesting that some of the lysine residues may be targets for both modifications.

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  • (PMID = 16207715.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA78433; United States / NIDDK NIH HHS / DK / DK50570; United States / NHLBI NIH HHS / HL / HL48819
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / GAL4 protein, S cerevisiae; 0 / Recombinant Fusion Proteins; 0 / Saccharomyces cerevisiae Proteins; 0 / Transcription Factors; 0 / Ubiquitin; 9007-49-2 / DNA; EC 1.13.12.- / Luciferases; K3Z4F929H6 / Lysine
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54. Tirumalae R, Böer A: Calcification and ossification in eccrine mixed tumors: underrecognized feature and diagnostic pitfall. Am J Dermatopathol; 2009 Dec;31(8):772-7
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  • [Title] Calcification and ossification in eccrine mixed tumors: underrecognized feature and diagnostic pitfall.
  • BACKGROUND: Eccrine mixed tumors of the skin are rare adnexal neoplasms, and their morphological spectrum is not well established.
  • OBJECTIVE: To highlight the variation of the mesenchymal component of eccrine mixed tumors.
  • METHODS: Among 70, 000 skin biopsies, 5 were diagnosed as eccrine mixed tumors.
  • The stroma was mucinous and chondroid, calcification ranging from little to extensive with bone formation in 3 examples giving the impression of a chondroid or osseous neoplasm.
  • S-100 stained epithelial and chondroid stromal cells.
  • CONCLUSIONS: Eccrine mixed tumors are distinctive tumors that should not be lumped together with their apocrine counterparts.
  • [MeSH-major] Eccrine Glands / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Complex and Mixed / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Calcinosis. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 19730221.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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55. Dhanuthai K, Sappayatosok K, Kongin K: Pleomorphic adenoma of the palate in a child: a case report. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E73-5
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  • [Title] Pleomorphic adenoma of the palate in a child: a case report.
  • Salivary gland tumors are rare in children and the incidence differs from the adult counterpart.
  • When salivary gland tumors do arise in children, they preferentially affect major salivary glands, but minor salivary gland tumors have also been reported.
  • We reported the first case of palatal pleomorphic adenoma in a 13 year-old child from Thailand.
  • She came to Sawanpracharak hospital with the chief complaint of a swelling at the left side of the palate.
  • Differential diagnoses of a palatal swelling in children and treatment of pleomorphic adenoma at the palate were also discussed.
  • [MeSH-major] Adenoma, Pleomorphic. Palate, Soft. Salivary Gland Neoplasms. Salivary Glands, Minor

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  • (PMID = 19179953.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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56. Takeda Y, Kurose A: Pigmented mucoepidermoid carcinoma, a case report and review of the literature on melanin-pigmented salivary gland tumors. J Oral Sci; 2006 Dec;48(4):253-6
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  • [Title] Pigmented mucoepidermoid carcinoma, a case report and review of the literature on melanin-pigmented salivary gland tumors.
  • Perusal of the English-language literature revealed only four cases of salivary gland tumors with parenchymal pigmentation: three mucoepidermoid carcinomas and one pleomorphic adenoma.
  • The possible histogenesis of melanocytes in the salivary gland lesions is discussed, although no firm conclusion could be drawn.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Lip Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 17220625.001).
  • [ISSN] 1343-4934
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Melanins
  • [Number-of-references] 21
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57. Ryska A: [What is your diagnosis? Answer: Noninvasive (intracapsular) carcinoma in pleomorphic adenoma]. Cesk Patol; 2008 Jul;44(3):79, 85
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  • [Title] [What is your diagnosis? Answer: Noninvasive (intracapsular) carcinoma in pleomorphic adenoma].
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18783140.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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58. Nath AK, Kumari R, Thappa DM: Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. Indian J Dermatol Venereol Leprol; 2009 Nov-Dec;75(6):600-2
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  • [Title] Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution.
  • It may be associated with foci of various other appendageal tumors.
  • Histopathology revealed dermal lobules of ES with smaller foci of chondroid syringoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19915242.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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59. Ponce Bravo S, Ledesma Montes C, López Becerril U, Morales Sánchez I: Myoepithelial cells are the main component in pleomorphic adenomas? Med Oral Patol Oral Cir Bucal; 2007 Mar;12(2):E110-5
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  • [Title] Myoepithelial cells are the main component in pleomorphic adenomas?
  • OBJECTIVE: The aim of this study was to quantify by immunohistochemistry the number of myoepithelial cells (MyECs) in pleomorphic adenomas (PAs).
  • The amount of S-100 protein positive cells was quantified, their morphology was recorded and comparison among MyEC number with age, gender and involved gland were also done.
  • RESULTS: With S-100 protein, MyECs in normal salivary gland tissue were seen surrounding the ductual structures only.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biomarkers, Tumor / analysis. Myoepithelioma / pathology. S100 Proteins / analysis. Salivary Gland Neoplasms / pathology

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  • (PMID = 17322797.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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60. Du LX, Yuan JP, Guan H, Zhang WD, Liang BL: [Magnetic resonance imaging for diagnosis of parotid malignant tumors and the pathological basis]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 May;30(5):1107-10
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  • [Title] [Magnetic resonance imaging for diagnosis of parotid malignant tumors and the pathological basis].
  • OBJECTIVE: To investigate magnetic resonance imaging (MRI) features of parotid malignant tumors and study their pathological basis.
  • METHODS: Forty-seven patients with parotid malignant tumors confirmed by surgery (41 patients) or biopsy (6 patients) were enrolled in this study.
  • Each of the MRI features was analyzed retrospectively and the typical MRI findings of common parotid malignant tumors were summarized.
  • RESULTS: MRI allowed accurate diagnosis of parotid malignant tumors.
  • Four patients with low-grade mucoepidermoid carcinoma showed well-defined tumor margin and were difficult to distinguish from benign tumors.
  • Six patients with high-grade mucoepidermoid carcinoma had obscure margin of the tumor which easily underwent necrosis with liable lymph node involvement.
  • The 8 cases of adenoid cystic carcinoma was characterized by extensive invasion surrounding the parotid gland.
  • Most of 8 cases of malignant pleomorphic adenoma still showed high and heterogeneous signal on T2WI, with irregular shape and poorly defined margin.
  • The 4 cases of acinic cell carcinoma showed either regular or irregular tumor morphology, presenting with high signal intensity on T1WI and T(2)WI.
  • CONCLUSION: MRI is an important modality for the diagnosis of parotid malignant tumors.
  • Most of the common parotid malignant tumors have characteristic MRI and pathological features, which make possible their differential diagnosis.

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  • (PMID = 20501408.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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61. Foschini MP, Krausz T: Salivary gland-type tumors of the breast: a spectrum of benign and malignant tumors including "triple negative carcinomas" of low malignant potential. Semin Diagn Pathol; 2010 Feb;27(1):77-90
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  • [Title] Salivary gland-type tumors of the breast: a spectrum of benign and malignant tumors including "triple negative carcinomas" of low malignant potential.
  • Salivary gland-type neoplasms of the breast are uncommon and comprise numerous entities analogous to that more commonly seen in salivary glands.
  • The clinicopathologic spectrum ranges from benign to malignant but there are important differences as compared with those of their salivary counterpart.
  • In the breast, benign adenomyoepithelioma is recognized in addition to malignant one, whereas in the salivary gland a histologically similar tumor is designated as epithelial-myoepithelial carcinoma without a separate benign subgroup.
  • Mammary adenoid cystic carcinoma is a low-grade neoplasm compared with its salivary equivalent.
  • It is also important to appreciate that in contrast to "triple negative" conventional breast carcinomas with aggressive course, most salivary-type malignant breast neoplasms behave in a low-grade manner.
  • Most of these tumors are capable of differentiating along both epithelial and myoepithelial lines, but the amount of each lineage-component varies from case to case, contributing to diagnostic difficulties.
  • Well established examples of this group include pleomorphic adenoma, adenomyoepithelioma, and adenoid cystic carcinoma.
  • Another family of salivary gland-type mammary epithelial neoplasms is devoid of myoepithelial cells.
  • The number of cases of salivary gland-type mammary neoplasms in the published data is constantly increasing but some of the rarest subtypes like polymorphous low-grade adenocarcinoma and oncocytic carcinoma are "struggling" to become clinically relevant entities in line with those occurring more frequently in salivary glands.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Breast Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Adenomyoepithelioma / metabolism. Adenomyoepithelioma / pathology. Breast Neoplasms, Male / metabolism. Breast Neoplasms, Male / pathology. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Receptor, ErbB-2 / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 20306833.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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62. Ascani G, Messi M, Balercia P: [Surgical management of pleomorphic adenoma of the salivary glands: our experience]. G Chir; 2008 Aug-Sep;29(8-9):343-6
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  • [Title] [Surgical management of pleomorphic adenoma of the salivary glands: our experience].
  • [Transliterated title] Trattamento dell'adenoma pleomorfo delle ghiandole salivari: nostra esperienza.
  • BACKGROUND: Pleomorphic adenoma is a benign epithelial tumour of adenoid structure preferentially arising from the parotid gland.
  • AIM: To analyse the outcome of patients with pleomorphic adenoma from salivary glands in order to evaluate the surgical strategy.
  • PATIENTS AND METHODS: This is an audit of a 15-year period where 347 pleomorphic adenomas of the salivary glands were treated by the authors.
  • RESULTS: The pleomorphic adenoma preferentially originated in the parotid gland (89.1%), and rarely in other glands.
  • The tumour occurred more often in females than in males (F:M=1.5).
  • CONCLUSION: The epidemiological aspects of pleomorphic adenoma of salivary glands retrieved in our study are similar to those reported in literature; moreover this study demonstrates that pericapsular enucleation is a viable alternative to superficial parotidectomy for the majority of parotid localizations, associated with reduced morbidity without oncological compromise.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 18834565.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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63. Wu F, Huang CC, Fu CH, Chen YL, Lee TJ: Transnasal endoscopic surgery for intranasal pleomorphic adenomas. B-ENT; 2010;6(1):43-7
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  • [Title] Transnasal endoscopic surgery for intranasal pleomorphic adenomas.
  • OBJECTIVES: To review a case series of patients treated for intranasal pleomorphic adenoma by endoscopic surgery.
  • MATERIALS AND METHODS: From January 1995 to August 2008, nine patients with intranasal pleomorphic adenoma underwent endoscopic endonasal surgery for tumour removal at our tertiary referral center.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Nasal Cavity. Nose Neoplasms / surgery

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  • (PMID = 20420079.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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64. Jung YH, Hah JH, Sung MW, Kim KH: Parotidotomy approach for a midcheek mass: a new surgical strategy. Laryngoscope; 2010 Mar;120(3):495-9
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  • OBJECTIVES/HYPOTHESIS: To report the feasibility and the results of a new surgical strategy for midcheek masses we called the parotidotomy approach.
  • The parotid gland was fully bisected along the course of the zygomatic and buccal branches of the facial nerve to provide access to the midcheek mass.
  • The bisected parotid gland was repositioned after mass excision.
  • The parotidotomy approach was accomplished in two cases with a malignant tumor (one acinic cell carcinoma, one low-grade mucoepidermoid carcinoma), four with a benign tumor (two pleomorphic adenoma, one basal cell adenoma, one facial nerve schwannoma), and in one case with a chronic inflammatory lesion (chronic sialadenitis).
  • For the two malignant tumors, there was no evidence of recurrence or metastasis at 2-year and 2.5-year follow-ups.

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  • (PMID = 20058313.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Persson O, Krogh M, Saal LH, Englund E, Liu J, Parsons R, Mandahl N, Borg A, Widegren B, Salford LG: Microarray analysis of gliomas reveals chromosomal position-associated gene expression patterns and identifies potential immunotherapy targets. J Neurooncol; 2007 Oct;85(1):11-24
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  • Gliomas are among the most aggressive malignant tumors and the most refractory to therapy, in part due to the propensity for malignant cells to disseminate diffusely throughout the brain.
  • We have also included smaller groups of grade II and grade III tumors of mixed astrocytic and oligodendroglial origin as comparison.
  • We developed a novel algorithm to analyze the gene expression data from the perspective of chromosomal position, and identified distinct regions of the genome that displayed coordinated expression patterns that correlated significantly to tumor grade.
  • [MeSH-minor] Algorithms. Biomarkers, Tumor. Cluster Analysis. DNA, Complementary / biosynthesis. DNA, Complementary / genetics. DNA, Neoplasm / biosynthesis. DNA, Neoplasm / genetics. Drug Delivery Systems. Gene Expression Profiling. Gene Expression Regulation, Neoplastic / genetics. Gene Expression Regulation, Neoplastic / physiology. Humans. In Situ Hybridization. Models, Statistical. Oligonucleotide Array Sequence Analysis. Treatment Outcome

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  • (PMID = 17634744.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA082783-07; United States / NCI NIH HHS / CA / R01 CA082783-06; United States / NCI NIH HHS / CA / CA082783; United States / NCI NIH HHS / CA / R01 CA082783; United States / NIGMS NIH HHS / GM / 5T32 GM07367
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Complementary; 0 / DNA, Neoplasm
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66. Herce-López J, Salazar-Fernández CI, Mayorga-Jiménez F, Gallana-Alvarez S, Pérez-Sánchez JM: Synchronous unilateral parotid neoplasms. A case report. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E90-2
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  • The parotid gland is the most usual location of benign neoplasms affecting major salivary glands and quite often the recurrence of these tumours is noticed, specially in the case of pleomorphic adenoma.
  • The occurrence of multiple tumours in the parotid glands is rare and the majority of these are multifocal Warthin's tumors (papillary cystadenoma lymphomatosum).
  • The simultaneous development of tumours with different histological types is unusual and when it occurs, the most common combination is a pleomorphic adenoma and a Warthin's tumor.
  • There are many articles about Multiple Parotid Tumors (MPT) but only a few of them are focused on unilateral synchronous benings tumors, being pleomorphic adenoma and Warthin's these tumors.
  • The report describes a 55 year old female with a pleomorphic adenoma occurring synchronously with a Warthin's tumor within the superficial lobe of her left parotid gland.
  • [MeSH-major] Adenolymphoma. Adenoma, Pleomorphic. Neoplasms, Multiple Primary. Parotid Neoplasms

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  • (PMID = 19179956.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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67. Siddaraju N, Murugan P, Basu D, Verma SK: Preoperative cytodiagnosis of cystic pleomorphic adenoma with squamous metaplasia and cholesterol crystals: a case report. Acta Cytol; 2009 Jan-Feb;53(1):101-4
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  • [Title] Preoperative cytodiagnosis of cystic pleomorphic adenoma with squamous metaplasia and cholesterol crystals: a case report.
  • BACKGROUND: Pleomorphic adenoma with extensive squamous metaplasia and cystic change may cause diagnostic confusion both in cytology and histopathology, which stresses the need for a guarded approach while interpreting such lesions.
  • Routine fine needle aspiration (FNA) yielded mucoid fluid, mixed with whitish particles.
  • The cystic nature of the swelling caused some degree of diagnostic dilemma; however, ultimately, a cytologic diagnosis of "pleomorphic adenoma with squamous metaplasia and cystic change" was offered, which was confirmed by subsequent histopathologic examination.
  • CONCLUSION: Our case emphasizes the need for a cautious and systematic approach in the cytologic and histopathologic interpretation of cystic pleomorphic adenoma with metaplastic epithelial changes.
  • Cholesterol crystals found in the aspirate material of our case is a rare finding in pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Cholesterol / analysis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 19248563.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 97C5T2UQ7J / Cholesterol
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68. Zhu JP, Zhang YY, Li Y, Hu HT, Li B, Xiang R: [FTIR spectroscopic investigation of normal and malignant pleomorphic adenoma]. Guang Pu Xue Yu Guang Pu Fen Xi; 2009 Nov;29(11):2947-50
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  • [Title] [FTIR spectroscopic investigation of normal and malignant pleomorphic adenoma].
  • The FTIR (Fourier transform infrared) spectra of malignant pleomorphic adenoma tissues and surrounding normal tissues were investigated using the Spectrum GX FTIR Spectrometer.
  • The results indicate that there were differences in the Fourier transform infrared spectra between the malignant pleomorphic adenoma tissues and the surrounding normal tissues at some bands. (a) Amide I band location related to the protein in milignant pleomorhic adenoma tissues shifted to a higher wave number compared to the normal tissues, and the absorption was increased in tumor tissues.
  • (b) The peak position related to PO2(-1) group in nucleic acid shifted to a higher wave number after canceration, and the absorption was stronger in tumor tissues compared to the normal tissues;.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Spectroscopy, Fourier Transform Infrared

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  • (PMID = 20101960.001).
  • [ISSN] 1000-0593
  • [Journal-full-title] Guang pu xue yu guang pu fen xi = Guang pu
  • [ISO-abbreviation] Guang Pu Xue Yu Guang Pu Fen Xi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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69. Huerva V, Sanchez MC, Egido RM, Matías-Guiu X: Pleomorphic adenoma with extensive myoepithelial component (myoepithelioma) of the lower eyelid. Ophthal Plast Reconstr Surg; 2008 May-Jun;24(3):223-5
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  • [Title] Pleomorphic adenoma with extensive myoepithelial component (myoepithelioma) of the lower eyelid.
  • The pathologic study revealed clusters of tumor cells and some ductal proliferations.
  • A diagnosis of pleomorphic adenoma with extensive myoepithelial component (myoepithelioma) was made.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eyelid Neoplasms / pathology. Myoepithelioma / pathology. Neoplasm Recurrence, Local. Neoplasms, Multiple Primary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Middle Aged. Reoperation

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  • (PMID = 18520841.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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70. Kasliwal N, Mukul S, Saini SB: Hanging drop deformity of the nose. Indian J Otolaryngol Head Neck Surg; 2006 Apr;58(2):200-1
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  • A chondroid syringoma causing disfigurement of the nasal tip is reported.
  • It is a rare tumour which had to be approched with careful thought for cosmesis.

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  • [Cites] J Laryngol Otol. 1997 Sep;111(9):862-4 [9373555.001]
  • [Cites] Cancer. 1959 May-Jun;12(3):537-43 [13652101.001]
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  • (PMID = 23120288.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450770
  • [Keywords] NOTNLM ; Chondroid syringoma, nasal tip
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71. Kajor M, Gierek T, Markowski J, Pajak J: Schwannomalike mixed tumor of the parotid gland: a case report. Acta Cytol; 2006 Sep-Oct;50(5):529-30
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  • [Title] Schwannomalike mixed tumor of the parotid gland: a case report.
  • BACKGROUND: Schwannomalike mixed tumor is a rare benign tumor of the parotid glands.
  • CASE: A 75-year-old woman presented with a tumor 3 cm in diameter localized in her left parotid gland.
  • Morphologic examinations were performed.
  • CONCLUSION: FNA cytology was very useful in the diagnosis of this rare tumor of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Neurilemmoma / diagnosis. Parotid Gland / pathology. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Digestive System Surgical Procedures. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Predictive Value of Tests. Schwann Cells / metabolism. Schwann Cells / pathology. Treatment Outcome

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  • (PMID = 17017438.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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72. Al-Naami MY, Guraya SY, Arafah MM, Al-Zobydi AH, Al-Tuwaijri TA: Clinicopathological pattern of malignant parotid gland tumors in Saudi Arabia. Saudi Med J; 2008 Mar;29(3):413-7
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  • [Title] Clinicopathological pattern of malignant parotid gland tumors in Saudi Arabia.
  • OBJECTIVE: To report our experience of varied presentations and diverse histopathological spectrum of parotid gland malignancies.
  • METHODS: This retrospective analysis incorporated patients with histological evidence of malignant parotid tumors at King Khalid University Hospital, Riyadh, Saudi Arabia over a 20-year period from 1984 through 2004.
  • Nine (28.1%) patients had mucoepidermoid carcinoma, 8 (25%) adenoid cystic carcinoma, 6 (18.7%) adenocarcinoma, not otherwise specified, and 2 (6.2%) were reported to have carcinoma in pleomorphic adenoma.
  • Twenty (62.5%) specimens revealed high-grade aggressive lesions, and out of these, 19 (59.3%) patients presented with stage III/IV disease.
  • CONCLUSION: Malignant parotid tumors are exceedingly rare, occurring at a relatively earlier age group with male preponderance, and invariably declare at a late clinical stage in our community.
  • Histopathological features hallmark a locally advanced disease with an aggressive behavior.

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  • (PMID = 18327370.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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73. Kopeć T, Szyfter W: [Deep lobe of parotid gland tumors]. Otolaryngol Pol; 2006;60(3):317-24
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  • [Title] [Deep lobe of parotid gland tumors].
  • INTRODUCTION: Surgery of the parotid gland tumors can be difficult because of the presence of the facial nerve branches in the parotid tissue.
  • The aim of the surgical treatment is complete removal of the tumor without damaging the facial nerve.
  • MATERIAL AND METHODS: In the years of 2002-2004 208 patients with the parotid gland tumors were treated.
  • There were 177 benign and 31 malignant tumors.
  • 159 tumors were located in the superficial lobe of the parotid gland, 35 in the superficial and the deep lobe, and 14 only in the deep lobe.
  • RESULTS: In cases concerning the operations of the tumors located in the deep lobe, the facial nerve branches had to be exposed with help of the microscopic operating techniques.
  • All tumors were removed totally.
  • A paralysis of the facial nerve was observed in two cases of the pleomorhic adenoma with a diameter over 6 cm, and in 9 cases of malignant tumors of the superficial and the deep lobe, where the main trunk or the branches of the facial nerve were integrated with the tumor mass.
  • CONCLUSION: Surgical treatment of the parotid gland tumors presented in our study demonstrates good results.
  • The risk of facial nerve paresis is higher in malignant tumors and big pleomorphic adenomas.
  • [MeSH-major] Frontal Lobe. Parotid Gland / surgery. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery

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  • (PMID = 16989442.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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74. Colella G, Biondi P, Itro A, Compilato D, Campisi G: Warthin's tumor distribution within the parotid gland. A feasible etiologic source from lymph nodal tissue. Minerva Stomatol; 2010 May;59(5):245-9, 250-2
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  • [Title] Warthin's tumor distribution within the parotid gland. A feasible etiologic source from lymph nodal tissue.
  • AIM: Warthin's tumor (WT) is the second commonest parotid gland neoplasm after pleomorphic adenoma (PA).
  • It mainly arises from the lower pole of the superficial parotid lobe (i.e., tail of gland), a site with the greatest distribution of intra-parotid lymph nodes, and its definitive etiopathogenesis is still unclear.
  • The aim of this study was to support the strict topic and etiologic link hypothesised between this tumor and the intraparotid lymph nodes, as being massively present in the tail, by assessing the WT distribution within the parotid gland.
  • In all sample, staging of parotid gland tumors was defined by sonography and magnetic resonance imaging.
  • Furthermore, tumor localization, size, bilaterality and multifocality were assessed according to radiological, intraoperative and histopathological findings.
  • CONCLUSION: Since the tail has been well known to present the greatest distribution of intra-parotid lymph nodes, our clinical findings on WT parotid localization could suggest the possible origin of this tumor from epithelial salivary gland ductal inclusions, as being likely entrapped during embryogenesis within the intra-parotid lymph nodes, and could support the hypothesis of a heterotopy in the pathogenesis of WT.
  • However, this suggestive hypothesis based only on clinical and "topographic" data should be confirmed by histopathological studies about the presence of the salivary ductal elements trapped within the intra-parotid lymph nodes.

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  • (PMID = 20502429.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
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75. Jang YJ, Kim JK, Park SB, Cho KS: Variable CT findings of epithelial origin ovarian carcinoma according to the degree of histologic differentiation. Korean J Radiol; 2007 Mar-Apr;8(2):120-6
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  • The CT images were retrospectively evaluated with regard to bilateral ovarian involvement, the tumor's nature, lymphadenopathy, adjacent organ invasion, peritoneal tumor seeding, a large amount of ascites and distant metastasis.
  • In cystic, predominantly cystic and mixed tumors, the tumor wall, septa, papillary projection and necrosis in the solid portion were assessed.
  • The frequency of a predominantly solid or solid nature was greater in the moderately and poorly differentiated carcinomas than in the well differentiated carcinomas (p < 0.0001).
  • In the 87 tumors with a cystic, predominantly cystic or mixed nature, septa greater than 3 mm, papillary projection and necrosis in the solid portion were more common in the poorly differentiated carcinoma (91%, 91% and 77%, respectively) than in the moderately (64%, 68% and 34%, respectively) and well differentiated carcinomas (63%, 47% and 27%, respectively) (p < 0.05).
  • Lymphadenopathy, organ invasion, tumor seeding and a large amount of ascites were more common in the poorly differentiated carcinomas (38%, 27%, 73% and 69%, respectively) than in the moderately (13%, 10%, 48% and 45%, respectively) and well differentiated carcinomas (3%, 0%, 10% and 17%, respectively) (p < 0.05).

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  • (PMID = 17420629.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide; JR13W81H44 / Iopamidol
  • [Other-IDs] NLM/ PMC2626777
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76. Yuan WH, Hsu HC, Chou YH, Hsueh HC, Tseng TK, Tiu CM: Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands. Clin Imaging; 2009 Sep-Oct;33(5):348-53
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  • [Title] Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • Our aim was to assess the specific ultrasonic characteristics of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • METHODS: We retrospectively reviewed and analyzed the ultrasonographic (US) features of 19 pleomorphic adenomas in 16 patients and 29 Warthin's tumors in 20 patients.
  • The features included tumor size, echotexture, boundary, and shape on gray-scale US imaging and grading and distribution of tumor vascularity on color Doppler ultrasound (CDU).
  • Most of the tumors (87.5%) were >or=10 mm, and 93.8% were well defined.
  • Only two of 29 Warthin's tumors had the highest grade of vascularity (+++).
  • Predominantly central blood flow was present in 58.6% of Warthin's tumors and 42.1% of pleomorphic adenomas.
  • Lobulated margin (shape) was noted in 84.2% of pleomorphic adenomas and 51.7% of Warthin's tumors (P<.05).
  • Anechoic cystic components were present in 13 (44.8%) of 29 Warthin's tumors and in only one pleomorphic adenoma (1/19, 5.3%) (P<.01).
  • CONCLUSION: Most pleomorphic adenomas were lobulated.
  • Internal anechoic cystic components were absent from pleomorphic adenomas but present in some Warthin's tumors.
  • The grading and distribution of blood flow signals on CDU provided only limited additional diagnostic information for distinguishing pleomorphic adenomas from Warthin's tumors.
  • Gray-scale ultrasonography is a useful method for evaluating and distinguishing pleomorphic adenomas from Warthin's tumors.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Echocardiography, Doppler, Color / methods. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 19712813.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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77. Muzumdar DP, Goel A, Fattepurkar S: Petroclival mixed meningioma. J Clin Neurosci; 2005 Apr;12(3):301-3
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  • [Title] Petroclival mixed meningioma.
  • The tumour was of mixed histopathology; the anterior part, in relationship to the cavernous sinus, was a syncitial meningioma and the posterior part in the petroclival region was a transitional meningioma.
  • The two histological subtypes of meningioma within the same tumour displayed remarkable differences in their radiological features, nature of extensions, relationship with the adjoining structures and consistency.

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  • (PMID = 15851087.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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78. Kuroda N, Moriki T, Oguri H, Maeda N, Toi M, Miyazaki E, Hiroi M, Fukaya T, Enzan H: Malignant müllerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells. APMIS; 2005 Sep;113(9):643-6
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  • [Title] Malignant müllerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells.
  • Histologically, proliferation of undifferentiated neoplastic cells with marked cytological atypia predominated in the tumor.
  • A diagnosis of malignant müllerian mixed tumor (MMMT) was made.

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  • (PMID = 16218942.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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79. Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, Van de Ven WJ, Shivdasani RA: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab; 2007 Nov;6(5):406-13
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  • Here we report that the transcription factor pleomorphic adenoma gene-like 2 (PlagL2) is essential for this aspect of dietary lipid metabolism.

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  • (PMID = 17983586.001).
  • [ISSN] 1550-4131
  • [Journal-full-title] Cell metabolism
  • [ISO-abbreviation] Cell Metab.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK48873; United States / NIDDK NIH HHS / DK / R01 DK56626; United States / NIDDK NIH HHS / DK / R01 DK61139
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chylomicrons; 0 / DNA-Binding Proteins; 0 / Dietary Fats; 0 / Plagl2 protein, mouse; 0 / RNA-Binding Proteins; 0 / Transcription Factors
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80. Zamolo G, Coklo M, Petković M, Batinac T, Bosnar A, Manestar D, Dekanić A, Vojniković B: Recurrent pleomorphic adenoma of epipharynx following irradiation therapy. Coll Antropol; 2005 Jun;29(1):185-7
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  • [Title] Recurrent pleomorphic adenoma of epipharynx following irradiation therapy.
  • We present a case of a 67-year-old female patient having a pleomorphic adenoma of epipharynx with intact fibrous capsula, which despite its benignity recurred and, moreover, responded quite well to irradiation therapy.
  • Three years later, when the CT showed tumor enlargement she accepted only irradiation therapy, resulting in significant reduction of tumor size.
  • Five years later the tumor recurred but without malignant transformation.
  • After a three-year follow-up the patient has no symptoms of the tumor enlargement.
  • This case shows that the irradiation therapy might be quite effective in the treatment of pleomorphic adenoma of epipharynx, but it is clear that much better results could be accomplished in combination with the surgery.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / radiotherapy. Neoplasm Recurrence, Local / radiotherapy. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / radiotherapy

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  • (PMID = 16117320.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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81. Santos GC, Carvalho KC, Falzoni R, Simoes AC, Rocha RM, Lopes A, Vassallo J, Reis LF, Soares FA, da Cunha IW: Glial fibrillary acidic protein in tumor types with cartilaginous differentiation. Mod Pathol; 2009 Oct;22(10):1321-7
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  • [Title] Glial fibrillary acidic protein in tumor types with cartilaginous differentiation.
  • GFAP is expressed in other neural tumors and pleomorphic adenoma and, less frequently, in cartilage tumors, chordomas, and soft tissue myoepitheliomas.
  • The aim of this study was to evaluate the role of GFAP and its reliability in nonglial tumors as an immunohistochemical marker.
  • We evaluated GFAP gene and protein expression using Q-PCR and immunohistochemistry, respectively, in 81 and 387 cases of soft tissue, bone tumors, and salivary pleomorphic adenomas.
  • Immunohistochemistry staining for GFAP was observed in all osteosarcomas (8 cases), all pleomorphic adenomas (7 cases), in 5 of 6 soft tissue myoepitheliomas, and in 21 of 76 chondrosarcomas.
  • By Q-PCR, GFAP was highly expressed in pleomorphic adenomas and, to a lesser extent, chondrosarcomas, soft tissue myoepitheliomas, and chondroblastic osteosarcomas.
  • GFAP is a potential marker for tumors with cartilaginous differentiation, supported by evidence that GFAP is expressed in certain cases of myoepithelial tumors by immunohistochemistry, including soft tissue myoepitheliomas, which are related to cartilaginous differentiation.
  • These findings contribute significantly to the diagnosis of soft tissue myoepitheliomas with cartilaginous differentiation and chondroblastic osteosarcoma in mesenchymal tumors.
  • [MeSH-major] Adenoma, Pleomorphic / chemistry. Biomarkers, Tumor / analysis. Bone Neoplasms / chemistry. Cartilage / chemistry. Glial Fibrillary Acidic Protein / analysis. Myoepithelioma / chemistry. Salivary Gland Neoplasms / chemistry. Soft Tissue Neoplasms / chemistry

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  • (PMID = 19668151.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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82. Eslami B, Rahimi H, Rahimi F, Khiavi MM, Ebadifar A: Diagnostic value of silver nitrate staining for nucleolar organizer regions in selected head and neck tumors. J Cancer Res Ther; 2006 Jul-Sep;2(3):129-31
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  • [Title] Diagnostic value of silver nitrate staining for nucleolar organizer regions in selected head and neck tumors.
  • BACKGROUND: The present study is aimed to assess the usefulness of silver nitrate staining of nucleolar organizer regions (NORs) as a quantitative criterion for the diagnosis of selected head and neck tumors.
  • The samples consisted of 21 squamous cell carcinoma (SCC) of larynx, 28 SCC of oral mucosa and 36 samples of most common salivary gland tumors.
  • RESULTS: A significant difference was seen in the number of AgNOR dots between oral and laryngeal SCC with surrounding dysplastic and normal tissues (P < 0.001) and also between mucoepidermoid carcinoma and adenoid cystic carcinoma with pleomorphic adenoma and normal salivary gland tissue (P < 0.001).
  • CONCLUSION: The silver nitrate staining for NORs is a useful method for aiding the diagnosis of malignant and dysplastic mucosal lesions and also malignant and benign salivary gland tumors.
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Humans. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17998691.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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83. Olajide TG, Alabi BS, Badmos BK, Bello OT: Pleomorphic adenoma of the lateral nasal wall--a case report. Niger Postgrad Med J; 2009 Sep;16(3):227-9
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  • [Title] Pleomorphic adenoma of the lateral nasal wall--a case report.
  • AIM/BACKGROUND: We report a rare case of pleomorphic adenoma arising from the lateral nasal wall.
  • The microscopic finding showed a lobular duct-like structure within a loose chondromyxoid stroma, which are histological characteristics of pleomorphic adenoma.
  • CONCLUSIONS: Her post-operative clinic visits were uneventful, and she is currently disease-free; nine months after surgery.
  • The diagnosis, clinical behaviour and treatment of pleomorphic adenoma of the lateral nasal wall are discussed from a review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Nasal Cavity / radiography. Nose Neoplasms / pathology

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  • (PMID = 19767912.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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84. Porter N, Sandhu A, O'Connell TB, Selva D, Leibovitch I: Pleomorphic adenoma of the palpebral lobe of the lacrimal gland. Otolaryngol Head Neck Surg; 2007 Feb;136(2):328-9
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  • [Title] Pleomorphic adenoma of the palpebral lobe of the lacrimal gland.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Eye Neoplasms / surgery. Lacrimal Apparatus

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  • (PMID = 17275570.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Araújo VC, Demasi AP, Furuse C, Altemani A, Alves VA, Freitas LL, Araújo NS: Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma. Appl Immunohistochem Mol Morphol; 2009 Jul;17(4):312-8
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  • [Title] Collagen type I may influence the expression of E-cadherin and beta-catenin in carcinoma ex-pleomorphic adenoma.
  • Carcinoma ex-pleomorphic adenoma (CXPA) is an aggressive salivary gland malignancy, usually derived from a long-standing or a recurrent benign tumor, the pleomorphic adenoma (PA).
  • In the context of dynamic reciprocity, changes in the composition and structure of extracellular matrix proteins and cell surface receptors have been frequently associated with dysfunctional adhesion and invasive behavior of tumor cells.
  • In this study, different progression stages of CXPA were investigated regarding the expression of the major extracellular matrix proteins, collagen type I, and of E-cadherin and beta-catenin, the components of adherens junctions.
  • By immunohistochemical analysis, we have demonstrated that direct contact of tumor cells with fibrillar type I collagen, particularly near the invasive front and in invasive areas prevailing small nests of CXPA cells, could be associated with reduced expression of the E-cadherin and beta-catenin adhesion molecules and with invasive behavior of epithelial, but not of CXPA with myoepithelial component.

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  • (PMID = 19276972.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / Collagen Type I; 0 / Neoplasm Proteins; 0 / beta Catenin
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86. Kitagawa M, Ogawa I, Shima K, Hashimoto S, Kudo Y, Miyauchi M, Tahara H, Shimono M, Takata T: Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene. Int J Oncol; 2007 Aug;31(2):339-44
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  • [Title] Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene.
  • Pleomorphic adenomas (PAs) of salivary glands are characterized by the mixed appearance of epithelial and mesenchymal-like components such as myxoid and chondroid tissues.
  • Thus, clarification of the histodifferentiation of this unique salivary gland tumor using not only tissues in vivo but also PA cells cultured in vitro is necessary.
  • However, no in vitro model of PA has been reported, because normal and benign tumor cells tend to grow slowly and senesce quickly in culture.
  • The immortalized PA cells expressed mRNA of the pleomorphic adenoma gene 1 and showed epithelial and neoplastic myoepithelial characteristics by immunohistochemical immunofluorescence analyses and ultrastructural study.
  • [MeSH-major] Adenoma / pathology. Gene Expression Regulation, Neoplastic. Parotid Neoplasms / metabolism. Telomerase / genetics. Telomerase / physiology
  • [MeSH-minor] Aged. Cell Differentiation. Cytoplasm / metabolism. Female. Gene Expression Profiling. Humans. Immunohistochemistry. Microscopy, Fluorescence. Reverse Transcriptase Polymerase Chain Reaction. Transfection. Tumor Cells, Cultured

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  • (PMID = 17611690.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.7.49 / Telomerase
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87. Misago N, Narisawa Y: Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation. J Dermatol; 2006 Jan;33(1):2-9
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  • [Title] Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation.
  • To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation.
  • None of the other benign neoplasms with presumed apocrine differentiation showed CK15 expression.
  • AMT of the skin are unique among benign neoplasms with apocrine differentiation in their substantial and constant CK15 expression, suggesting that they derive from multipotent epithelial stem cells in the bulge.
  • [MeSH-major] Apocrine Glands / metabolism. Keratins / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adult. Aged. Biomarkers, Tumor. Case-Control Studies. Cystadenoma / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16469077.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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88. Wierzbicka M, Kopeć T, Szyfter W, Bem G: [Epidemiology of non-malignant salivary gland tumours based on 675 cases]. Otolaryngol Pol; 2010 Sep-Oct;64(5):281-7
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  • [Title] [Epidemiology of non-malignant salivary gland tumours based on 675 cases].
  • Neoplasm of salivary glands constitutes about 3% of all tumours of head and neck.
  • Within the category we can differentiate tumours of a very different histological structure.
  • What lies behind such great differences in the changes within the salivary glands is complex embryogenesis of the glands.
  • About 80% of all tumours of salivary glands is located in parotid gland, from 10 to 20% - in submandibular gland and several percent in sublingual and small salivary gland.
  • This work aims at the assessment of the frequency of occurrence of non-malignant neoplasm in parotid and submandibular gland based on the material collected at the ENT Department of the Medical University in Poznan in the years 1995-2006.
  • In the 12-year period, 778 patients in total suffered from tumours of large salivary glands.
  • Main aim of this work has been achieved through the execution of partial steps: the analysis of the trends in occurrence of non-malignant neoplasm in the 12-year period, the analysis of the epidemiological differences: sex, age, place of residence - town or country, duration of symptoms, diameter of the tumour at the time the patient reported for treatment, histological structures that were carried on the basis of the comparison of data collected in the two periods of time: period I--the years 1995-2000 and period II--the years 2001-2006.
  • The frequency of operations on non-malignant tumours of salivary glands (as compared to the total number of operations) was 4.11% in the first period and 4.18% in the second.
  • In both periods the most frequent benign tumour was the mixed tumour (54.9% of all tumours) and constituted 60% and 54% of all tumours in the respective periods analyzed.
  • The next most frequently occurring tumour was Warthin's tumour, identified in 31.2% of the patients, in 23% in period I and 35% in period II.
  • Duration of the symptoms, ranged from 1 month to 20 years, 14 months on average, yet in 263 cases the tumour has been developing developed for over a year.
  • It was 3 cm with regard to the most frequently occurring tumours: adenoma polymorphum, adenoma monomorphum and cystadenolymphoma.
  • [MeSH-major] Rural Population / statistics & numerical data. Salivary Gland Diseases / epidemiology. Salivary Gland Diseases / pathology. Urban Population / statistics & numerical data
  • [MeSH-minor] Adult. Age Distribution. Age Factors. Aged. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Poland / epidemiology. Prognosis. Salivary Gland Neoplasms / epidemiology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology. Young Adult

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  • (PMID = 21166137.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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89. Okeley NM, Miyamoto JB, Zhang X, Sanderson RJ, Benjamin DR, Sievers EL, Senter PD, Alley SC: Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res; 2010 Feb 1;16(3):888-97
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  • The bystander activity of SGN-35 was determined using mixed tumor cell cultures consisting of CD30(+) and CD30(-) lines.
  • [MeSH-minor] Antibodies, Anti-Idiotypic / immunology. Bystander Effect / drug effects. Cell Line, Tumor. Cells, Cultured. Humans. Oligopeptides / metabolism

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  • [ErratumIn] Clin Cancer Res. 2011 Aug 15;17(16):5524
  • (PMID = 20086002.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Antigens, CD30; 0 / Immunoconjugates; 0 / Oligopeptides; 0 / cAC10-vcMMAE; 0 / monomethyl auristatin E
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90. Prades JM, Oletski A, Faye MB, Dumollard JM, Timoshenko AP, Veyret C, Peoc'h M, Martin C: [Parotid gland masses: diagnostic value of MR imaging with histopathologic correlations]. Morphologie; 2007 Mar;91(292):44-51
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  • [Title] [Parotid gland masses: diagnostic value of MR imaging with histopathologic correlations].
  • [Transliterated title] Morphologie IRM des tuméfactions de la glande parotide. Corrélations histopathologiques.
  • BACKGROUND AND PURPOSE: The purpose of our study has been to describe the pre-operatively MR Imaging appearance of masses in the parotid gland which may be sources of clinical and radiological confusion.
  • RESULTS-CONCLUSIONS: In case of pleomorphic adenoma (N=30) MR imaging sensibility, specificity and accuracy were respectively 87.5, 80.5 and 83%.
  • In case of Warthin tumors (N=13) the same values were respectively 45.5, 93 and 85%.
  • In case of malignant tumors (N=13) theses values were respectively 71, 89 and 87%.
  • Our routine MR Imaging study appears excellent not only for assessing the type and extent of benign salivary gland tumors and the relationship to adjacent structures, but also for determining whether the tumor is benign or malignant.
  • [MeSH-minor] Adenolymphoma / diagnosis. Adenolymphoma / pathology. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adult. Aged. Aged, 80 and over. Carcinoma / diagnosis. Carcinoma / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Parotitis / diagnosis

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  • (PMID = 17652005.001).
  • [ISSN] 1286-0115
  • [Journal-full-title] Morphologie : bulletin de l'Association des anatomistes
  • [ISO-abbreviation] Morphologie
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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91. Prasad SR, Surabhi VR, Menias CO, Raut AA, Chintapalli KN: Benign renal neoplasms in adults: cross-sectional imaging findings. AJR Am J Roentgenol; 2008 Jan;190(1):158-64
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  • [Title] Benign renal neoplasms in adults: cross-sectional imaging findings.
  • OBJECTIVE: A broad spectrum of benign renal neoplasms in adults shows characteristic ontogeny, histology, and tumor biology.
  • Benign renal tumors are classified into renal cell tumors, metanephric tumors, mesenchymal tumors, and mixed epithelial and mesenchymal tumors.
  • Select benign tumors show characteristic anatomic distribution and imaging features.
  • However, because of overlapping of findings between benign and malignant renal tumors, histologic evaluation may be required to establish a definitive diagnosis.
  • CONCLUSION: We attempt to provide a comprehensive, contemporary review of benign renal neoplasms that occur in adults, focusing on cross-sectional imaging characteristics.
  • [MeSH-minor] Adenofibroma / diagnosis. Adenoma / diagnosis. Adenoma, Oxyphilic / diagnosis. Adult. Aged. Angiomyolipoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Cross-Sectional Studies. Diagnosis, Differential. Female. Hemangioma / diagnosis. Humans. Leiomyoma / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18094306.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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92. Ogura E, Kageyama K, Fukumoto S, Yagihashi N, Fukuda Y, Kikuchi T, Masuda M, Suda T: Development of tumor-induced osteomalacia in a subcutaneous tumor, defined by venous blood sampling of fibroblast growth factor-23. Intern Med; 2008;47(7):637-41
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  • [Title] Development of tumor-induced osteomalacia in a subcutaneous tumor, defined by venous blood sampling of fibroblast growth factor-23.
  • Physical examination revealed an elastic tumor in the instep of the right foot, which the patient reported having since the age of 10 years.
  • Within the recent years, the tumor had grown in size and the patient developed lumbago.
  • To examine the existence of a fibroblast growth factor-23 (FGF-23)-producing tumor, venous blood was collected from four main veins.
  • After the resection of the tumor, the histopathology was consistent with a phosphaturic mesenchymal tumor (mixed connective tissue variant).
  • Taken together, these results indicated that the development of osteomalacia in this patient was associated with the production of FGF-23 in the subcutaneous tumor.

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  • (PMID = 18379151.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / fibroblast growth factor 23; 62031-54-3 / Fibroblast Growth Factors
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93. Ercolino T, Becherini L, Valeri A, Maiello M, Gaglianò MS, Parenti G, Ramazzotti M, Piscitelli E, Simi L, Pinzani P, Nesi G, Degl'Innocenti D, Console N, Bergamini C, Mannelli M: Uncommon clinical presentations of pheochromocytoma and paraganglioma in two different patients affected by two distinct novel VHL germline mutations. Clin Endocrinol (Oxf); 2008 May;68(5):762-8
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  • One patient was studied for the presence of an adrenal incidentaloma and the other for the presence of a neck tumour.
  • We identified two novel VHL point mutations: a L198V missense mutation in a 32-year-old female affected by a right adrenal compound and mixed tumour constituted by an epinephrine secreting Pheo, a ganglioneuroma and an adrenocortical adenoma, and a T152I missense mutation in a 24-year-old female affected by a left carotid body tumour.
  • CONCLUSIONS: These cases enlarge the list of VHL mutations and add new insights in the clinical variability of VHL disease, thus confirming the importance of genetic testing in patients affected by apparently sporadic Pheos or PGLs.
  • [MeSH-major] Adrenal Gland Neoplasms / genetics. Head and Neck Neoplasms / genetics. Paraganglioma / genetics. Pheochromocytoma / genetics. von Hippel-Lindau Disease / genetics


94. Said S, Campana J: Myoepithelial carcinoma ex pleomorphic adenoma of salivary glands: a problematic diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Feb;99(2):196-201
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  • [Title] Myoepithelial carcinoma ex pleomorphic adenoma of salivary glands: a problematic diagnosis.
  • We report the case of a 77-year-old woman who presented with a 6-year history of pleomorphic adenoma with multiple recurrences.
  • Despite the clinical suspicion of a malignant process, the detection of myoepithelial carcinoma ex pleomorphic adenoma was not achieved by means of a preoperative biopsy or a frozen section removed intraoperatively, as the lesion only showed mild cytological atypia with no frank malignant features.
  • Only a thorough evaluation of the resected tumor enabled the diagnosis of a malignancy.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Cell Transformation, Neoplastic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 15660092.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Oliai BR, Sheth S, Burroughs FH, Ali SZ: "Parapharyngeal space" tumors: a cytopathological study of 24 cases on fine-needle aspiration. Diagn Cytopathol; 2005 Jan;32(1):11-5
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  • [Title] "Parapharyngeal space" tumors: a cytopathological study of 24 cases on fine-needle aspiration.
  • The most common clinicoradiographic suspicion was a nerve sheath tumor.
  • Of the 18 cases considered diagnostic, there were nine (50%) pleomorphic adenomas (PAs); three (17%) squamous-cell carcinomas (SCC); and one each of oncocytoma, adenocarcinoma, not otherwise specified (NOS), adenoid cystic carcinoma, lipoma, neurofibroma, and non-Hodgkin lymphoma, together comprising the remaining 33%.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biopsy, Fine-Needle / methods. Carcinoma, Squamous Cell / pathology. Pharyngeal Neoplasms / pathology. Pharynx / pathology

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • [CommentIn] Diagn Cytopathol. 2006 Jan;34(1):82-3 [16355379.001]
  • (PMID = 15584054.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Rogers LR, Rock JP, Sills AK, Vogelbaum MA, Suh JH, Ellis TL, Stieber VW, Asher AL, Fraser RW, Billingsley JS, Lewis P, Schellingerhout D, Shaw EG, Brain Metastasis Study Group: Results of a phase II trial of the GliaSite radiation therapy system for the treatment of newly diagnosed, resected single brain metastases. J Neurosurg; 2006 Sep;105(3):375-84
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  • [Title] Results of a phase II trial of the GliaSite radiation therapy system for the treatment of newly diagnosed, resected single brain metastases.
  • The primary end point of the study was local tumor control.
  • METHODS: The authors conducted a prospective multiinstitutional phase II study of GliaSite brachytherapy prescribed at a 60-Gy dose administered to a 1-cm depth after resection of a single brain metastasis.
  • The most common tumor (54%) was non-small cell lung cancer.
  • Thirteen patients underwent reoperation for suspected tumor recurrence or radiation necrosis, and histological diagnoses included radiation necrosis without tumor (nine patients), radiation necrosis mixed with tumor (two patients), and tumor only (two patients).
  • Extracranial metastasis, tumor size, and radiation necrosis were significant factors affecting patient survival.

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  • [CommentIn] J Neurosurg. 2006 Sep;105(3):371-2; discussion 372-4 [16961128.001]
  • (PMID = 16961129.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study
  • [Publication-country] United States
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97. Chen Y, Tian K, Geng N, Yang MZ, Zhang WP: [The expression of matrix metalloproteinases and their tissue inhibitors in pleomorphic adenoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jan;40(1):58-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The expression of matrix metalloproteinases and their tissue inhibitors in pleomorphic adenoma].
  • OBJECTIVE: To examine the expression of MMPs and TIMPs in pleomorphic adenoma of salivary gland and to investigate the relationship between the expression and the biological behaviour of the tumor.
  • METHODS: Twenty-three cases of pleomorphic adenoma were divided into active type and common type according to their biological behavior.
  • Immunohistochemistry for MMP-2, MMP-9, TIMP-1, TIMP-2 and gelatin zymography analysis were performed in these 23 cases and in 6 malignant and 6 benign salivary gland tumors.
  • RESULTS: The immunoreactivity of MMP-2 protein and MMP-2/TIMP-1, 2 ratio were significantly higher in active pleomorphic adenoma than in common pleomorphic adenoma (P = 0.028, P = 0.009, P = 0.045).
  • The expression of active MMP-2, proMMP-9 and active MMP-9 were significantly higher in active pleomorphic adenoma than in common pleomorphic adenoma (P = 0.034, P = 0.021, P = 0.001).
  • There was no significant difference in expression of MMP-2, MMP-9, TIMP-1 and TIMP-2 between the salivary malignant tumor and active pleomorphic adenoma, also between the salivary benign tumor and common pleomorphic adenoma.
  • CONCLUSIONS: The expression of MMPs and TIMPs in active pleomorphic adenoma is similar to that in salivary carcinomas, and the expression in common pleomorphic adenoma also resembled to that in salivary adenoma.
  • The expression of MMP-2, 9 and TIMP-1, 2 is related to the biological behavior of pleomorphic adenoma of salivary gland.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Salivary Gland Neoplasms / metabolism. Tissue Inhibitor of Metalloproteinase-1 / metabolism. Tissue Inhibitor of Metalloproteinase-2 / metabolism

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  • (PMID = 15774155.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Tissue Inhibitor of Metalloproteinase-1; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.24 / MMP2 protein, human; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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98. Ihrler S, Schwarz S, Zengel P, Guntinas-Lichius O, Kirchner T, Weiler C: [Pleomorphic adenoma: pitfalls and clinicopathological forms of progression]. Pathologe; 2009 Nov;30(6):446-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic adenoma: pitfalls and clinicopathological forms of progression].
  • [Transliterated title] Das pleomorphe Adenom: Pitfalls in der Diagnostik und klinisch-pathologische Progressionsformen.
  • In the majority of cases the diagnosis of pleomorphic adenoma (PA) is straightforward.
  • In "monomorphic" types of PA problems may result: Epithelial-rich PA need to be distinguished from basal cell adenoma or canalicular adenoma.
  • Focal biphasic-tubular differentiation with CK7/18-positive ductal cells is good evidence for a tumour within the wide spectrum of PA.
  • The different progression steps of carcinoma ex pleomorphic adenoma (CEPA), starting with intraductal carcinoma, are highly relevant with respect to prognosis and therapy.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Reoperation. Salivary Ducts / pathology. Salivary Glands / pathology

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  • (PMID = 19844715.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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99. Takahira M, Minato H, Takahashi M, Karino K, Sugiyama K: Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. Ophthal Plast Reconstr Surg; 2007 Sep-Oct;23(5):407-9
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  • [Title] Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland.
  • In a 48-year-old male patient, a well-circumscribed, round tumor in the lacrimal fossa was detected by CT.
  • During total excision of the tumor, a wall of the tumor ruptured, resulting in leakage of the fluid contents.
  • The wall of the tumor formed a cyst that contained residual yellowish fluid.
  • Histologically, the cyst wall included an adenocarcinomatous component and a focus of pleomorphic adenoma.
  • The tumor was diagnosed as a carcinoma ex pleomorphic adenoma of the lacrimal gland.
  • The carcinoma cells showed positive immunoreactivity for androgen receptor and BRST-2, indicating that the tumor was equivalent to a salivary duct carcinoma.
  • This case demonstrates that a carcinoma ex pleomorphic adenoma of the lacrimal gland may develop in a cyst.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology

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  • (PMID = 17881995.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Baradaranfar MH, Dabirmoghaddam P: Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients. Arch Iran Med; 2006 Jul;9(3):244-9
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  • [Title] Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients.
  • OBJECTIVE: To report our experience with endoscopic surgery of benign tumors and tumor-like conditions of the nose and paranasal sinuses.
  • METHODS: The medical records of 105 patients with benign sinonasal tumor, who had undergone endoscopic surgery for removal of their neoplasm between 1997 and 2003, were retrospectively studied.
  • RESULTS: The studied patients included 32 with juvenile nasopharyngeal angiofibroma, 24 with inverted papilloma, 23 with benign fibroosseous lesions, 18 with pyogenic granuloma, 6 with intranasal hemangioma, and 2 with pleomorphic adenoma.
  • Eight cases of recurrent tumor--2 angiofibroma, 4 inverted papilloma, 1 fibrous dysplasia, and 1 osteoma--were noted and managed endoscopically alone or in combination with Caldwell-Luc approach.
  • CONCLUSION: Endoscopic surgery is a valuable tool for removal of benign tumors of the nose and paranasal sinuses in the hands of an experienced surgeon.
  • [MeSH-major] Endoscopy / methods. Nasopharyngeal Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Angiofibroma / diagnosis. Angiofibroma / surgery. Child. Diagnosis, Differential. Female. Follow-Up Studies. Hemangioma / diagnosis. Hemangioma / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Papilloma, Inverted / diagnosis. Papilloma, Inverted / surgery. Retrospective Studies. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 16859060.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Iran
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