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1. do Prado RF, Consolaro A, Taveira LA: Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study. Med Oral Patol Oral Cir Bucal; 2006 May;11(3):E247-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study.
  • OBJECTIVES: Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common.
  • The objective of this study was to detect the expression of beta-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions.
  • STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands).
  • RESULTS: All cases of glands, adenomas and carcinomas in pleomorphic adenomas have membranous and cytoplasmic immunostaining.
  • Higher beta-catenin index rates were seen mainly in salivary gland ducts and in ductal structures in the adenomas and carcinomas in pleomorphic adenomas.
  • There was protein loss in pleomorphic adenomas and cytoplasmic accumulation in carcinoma in pleomorphic adenomas.
  • CONCLUSIONS: The present study showed participation of the loss of beta-catenin adhesion molecule in the development of pleomorphic adenoma, and that the cytoplasmic accumulation of the molecule takes part in the malignant transformation of the pleomorphic adenoma into carcinoma in pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Carcinoma / metabolism. Neoplasms, Multiple Primary / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Glands / metabolism. beta Catenin / biosynthesis

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  • (PMID = 16648762.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / beta Catenin
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2. Agrawal A, Kumar A, Sinha AK, Kumar B, Sabira KC: Chondroid syringoma. Singapore Med J; 2008 Feb;49(2):e33-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma.
  • Pleomorphic adenoma, or chondroid syringoma (CS), is a rare, benign, skin appendageal tumour.
  • Because of the unremarkable clinical presentation of this rare tumour, the diagnosis is made on microscopic examination.
  • We present a case of a CS located over the forehead of a 32-year-old man.
  • In the evaluation of a middle-aged male patient with a small cutaneous nodule in the head and neck region, chondroid syringoma should also be considered in the differential diagnosis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Forehead / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18301822.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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3. Dalati T, Hussein MR: Juvenile pleomorphic adenoma of the cheek: a case report and review of literature. Diagn Pathol; 2009;4:32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Juvenile pleomorphic adenoma of the cheek: a case report and review of literature.
  • Pleomorphic adenoma, also called benign mixed tumor, is the most common tumor of the salivary glands.
  • About 90% of these tumors occur in the parotid gland and 10% in the minor salivary glands.
  • The most common sites of pleomorphic adenoma of the minor salivary glands are the palates followed by lips and cheeks.
  • In children, intraoral pleomorphic adenomas of the cheek are extremely rare with only three cases reported to date.
  • Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 17-year-old girl.
  • To conclude, pleomorphic adenoma should be considered in the differential diagnosis of cheek masses in youngsters.

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  • (PMID = 19772659.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2759908
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4. Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP: [Human kallikrein 13 expression in salivary gland tumors]. Int J Biol Markers; 2006 Apr-Jun;21(2):106-110

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Human kallikrein 13 expression in salivary gland tumors].
  • Petraki et al have previously described presence of hK13 in salivary gland tissue, localized to duct epithelia and some acinar cells.
  • The aim of this study was to determine whether hK13 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid carcinomas (MEC) and adenocarcinomas not otherwise specified (ANOS) of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of hK13.
  • Overall, staining in PA was significantly less than that seen in normal salivary gland tissue.
  • PLGA, ACC and ANOS each stained significantly more than normal salivary gland tissue while MEC and ACI did not.
  • Ductal cells and cells lining duct-like structures showed a higher intensity of staining than non-ductal cells in most tumors.
  • Tumors which exhibited only non-ductal cells also exhibited cytoplasmic staining.
  • In conclusion, we demonstrate the high expression of hK13 in several common salivary gland tumors.

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  • (PMID = 28207129.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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5. Okuda H, Tei N, Shimizu K, Imazu T, Yoshimura K, Kiyohara H: Chondroid syringoma of the scrotum. Int J Urol; 2008 Oct;15(10):944-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma of the scrotum.
  • A 70-year-old Japanese man complained of a nodular, non-tender scrotal mass, which had been gradually increasing in size over the last 10 years.
  • Excisional biopsy of the scrotal specimen revealed chondroid syringoma, a very rare benign tumor, more likely to occur in the head and neck region.
  • This is the eighth such case reported, and is an important type of scrotal tumor.
  • [MeSH-major] Adenoma, Pleomorphic. Genital Neoplasms, Male. Scrotum

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  • (PMID = 19138288.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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6. Nagata S, Jin YF, Yoshizato K, Kitamura M, Iizuka N, Song M, Tomoeda M, Yuki M, Kubo C, Yoshizawa H, Outani H, Hamada K, Araki N, Funauchi M, Tomita Y: Early uptake and continuous accumulation of thallium-201 chloride in a benign mixed tumor of soft tissue: case report. Diagn Pathol; 2010;5:34
Hazardous Substances Data Bank. THALLOUS CHLORIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early uptake and continuous accumulation of thallium-201 chloride in a benign mixed tumor of soft tissue: case report.
  • A case of benign mixed tumor of the soft tissue in a 64-year-old Japanese male is presented.
  • The patient underwent a resection of tumor, and the pathological diagnosis was a benign mixed tumor of soft tissue without high vascularity, characterized by histological features similar to pleomorphic adenomas in the salivary glands.
  • Immunohistochemical study proved expression of Na+/K+-ATPase of tumor cells.
  • Overexpression of Na+/K+-ATPase of the tumor might be responsible for the early uptake of Tl-201, and poor vascular structure in this tumor might lead to continuous accumulation.
  • The Tl-201 scintigraphic features of mixed tumor of soft tissue are assessed to resemble those of malignant soft tissue tumors.
  • [MeSH-major] Neoplasms, Complex and Mixed / radionuclide imaging. Radiopharmaceuticals. Soft Tissue Neoplasms / radionuclide imaging. Thallium. Tomography, Emission-Computed

  • Hazardous Substances Data Bank. THALLIUM, ELEMENTAL .
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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Aug;92(2):228-35 [11505272.001]
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  • (PMID = 20509963.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 7791-12-0 / thallium chloride; AD84R52XLF / Thallium; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
  • [Other-IDs] NLM/ PMC2887811
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7. López Campos D, Campos Bañales ME, López Aguado D: [Primary pleomorphic adenoma (chondroid syringoma) of the external auditory canal. Case report and literature review]. Acta Otorrinolaringol Esp; 2008 May;59(5):252-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary pleomorphic adenoma (chondroid syringoma) of the external auditory canal. Case report and literature review].
  • [Transliterated title] Adenoma pleomórfico primario (siringoma condroide) del conducto auditivo externo. A propósito de un caso y revisión de la literatura.
  • Chondroid syringoma of the external auditory canal is an extremely rare neoplasm, representing the cutaneous counterpart of pleomorphic adenoma of salivary glands.
  • This tumour is thought to derive from the apocrine duct of the folliculo-sebaceous-apocrine unit.
  • We report the case of a 68-year-old male in whom the clinical and radiological examinations showed a well-circumscribed tumour limited to the external auditory canal.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear Neoplasms / pathology. Ear, External / pathology

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  • (PMID = 18501163.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 12
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8. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review.
  • INTRODUCTION: Primary neoplasms of the external ear canal are rare, and 5% of these tumors are of glandular origin.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • An alternative theory holds that pleomorphic adenomas may well arise from ectopic salivary tissue present in the external ear canal.
  • These tumors are very rare and usually have a benign course.
  • In this report, we describe an unusual case of pleomorphic adenoma of the external auditory canal associated with chronic infection of the middle ear.
  • Subsequent biopsy and histologic examination revealed pleomorphic adenoma of the external ear canal, possibly with malignant elements.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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9. Smiri KH, Fenniche S, Marrak H, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I: [Chondroid syringoma]. Tunis Med; 2005 Jun;83(6):372-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Chondroid syringoma].
  • [Transliterated title] Le syringome chondroïde.
  • Chondroid syringoma is a benign sweat gland tumor.
  • This lesion is electively located in the craniofacial area, made of a subcutaneous painless tumor measuring from 0.5 to 3 cm.
  • Diagnosis can always be confirmed by histology which shows tubuloalveolar and gland like structures with two or more cuboidal cell lines in a fibroadipoid or chondroid stroma that is positively stained for Alcian blue.
  • Mixed tumors have a slow course; their progress to malignancy is rare but possible.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Disease Progression. Humans. Male. Middle Aged. Patient Satisfaction. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 16156416.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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10. Sato K, Ueda Y, Shimasaki M, Ozaki M, Nitta N, Chada K, Ishikawa Y, Katsuda S: Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. Pathol Res Pract; 2005;201(4):333-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature.
  • We report a case of pleomorphic adenoma (benign mixed tumor) of the breast, which is an extremely rare location for this tumor.
  • Examination of a 55-year-old woman unexpectedly revealed a mass measuring 0.8 cm in diameter in the subareolar region of the right breast.
  • Excisional biopsy was performed, and the tumor histologically showed pleomorphic adenoma composed of duct epithelial cells, myoepithelial cells, and a myxochondroid matrix.
  • The nuclei of the spindle and myoepithelial cells were immunoreactive for HMGI-C and HMGI(Y) proteins, indicating a histogenesis similar to pleomorphic adenoma of the salivary glands.
  • Sixty-nine cases of this type of tumor arising in the breast have been described previously.
  • Using imaging procedures, the tumor has occasionally been misdiagnosed as malignant clinically and even pathologically in frozen section diagnosis.
  • Careful diagnosis based on paraffin sections is required to avoid unnecessary aggressive surgery, and pathologists should include pleomorphic adenoma in the differential diagnosis of a demarcated, juxtaareolar, small hard mass.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. HMGA1a Protein / analysis. HMGA2 Protein / analysis. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Middle Aged. Receptors, Estrogen / analysis

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  • (PMID = 15991841.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; 0 / Receptors, Estrogen; 124544-67-8 / HMGA1a Protein
  • [Number-of-references] 32
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11. Borman H, Deniz LM, Ertas NM, Arikan U, Colak A: Chondroid syringoma of the hand. Scand J Plast Reconstr Surg Hand Surg; 2009;43(5):291-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma of the hand.
  • Chondroid syringoma is a rare cutaneous tumour that usually arises in the head and neck region and is rarely seen on the hands; it is rarely malignant at sites other than the head and neck.
  • We present a 56-year-old man with a chondroid syringoma of the hand that clinically resembled a vascular tumour.

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  • (PMID = 19863434.001).
  • [ISSN] 1651-2073
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Davidson JA, Wong V, Fraser R, Hirsh V: Comparison of primary tumor maximal standardized uptake value (SUV<sub>max</sub>) on preoperative [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and histological subtype in patients with non-small cell lung cancer (NSCLC). J Clin Oncol; 2009 May 20;27(15_suppl):7571

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of primary tumor maximal standardized uptake value (SUV<sub>max</sub>) on preoperative [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and histological subtype in patients with non-small cell lung cancer (NSCLC).
  • The SUV<sub>max</sub> is a semiquantitative measure of metabolic activity that can distinguish benign from malignant tissue but published data are conflicting regarding its ability to discriminate between major histological subtypes.
  • The SUV<sub>max</sub> values for each histological subtype, along with primary tumor sizes, were compared using F test and t-test analyses.
  • RESULTS: The 15 patients with SC and 5 with LC histology were found to have significantly greater preoperative SUV<sub>max</sub> values than the 19 patients with AC (mean 12.7 and 17.2 vs. 9.4, respectively, P < 0.05), despite the fact that no significant differences in tumor size were observed between histological subtypes.
  • CONCLUSIONS: These data suggest that SC pulmonary tumors have significantly greater uptake on PET/CT than AC tumors.
  • This finding may be helpful in the future when sufficient tissue cannot be obtained for pathological diagnosis or to identify the predominant pathology of mixed tumors.

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  • (PMID = 27963356.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Price PM, Asselin M, Koetz B, Dickinson C, Charnley N, Lorigan P, Valle J, Stratford M, Rustin G, Saleem A: A PET imaging study of the vascular disruptive agent OXi4503 to confirm in vivo mechanism of action in a phase I trial. J Clin Oncol; 2009 May 20;27(15_suppl):e14510

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 2 pts with MM (3.8 & 6.5 mg/m<sup>2</sup>) achieved stable disease.
  • Sustained tumour blood perfusion reduction (50% at 90min & 24hr) was seen in all metastases in the CRC pt treated at 15.4 mg/m<sup>2</sup> after just one dose & resulted in FDG reduction (23% in all 5 mets) & tumor marker response.
  • Doses between 1.9 & 11.0 mg/m<sup>2</sup> produced dose independent reductions in tumour perfusion which were more variable & less marked with 3/8 pts showing a reduction in tumour FDG uptake.
  • The 1pt studied at 28 days (8.5 g/m<sup>2</sup>) showed further sustained reduction in tumour blood flow (40%).
  • Characterisation of the mixed tumour perfusion response at lower doses will aid planning & assessing combination studies.

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  • (PMID = 27963518.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Piulats JM Sr, Nadal M, Martinez-Iniesta M, Puertas S, Gonzalez S, Vidal A, Condom E, Germa-Lluch J, Garcia Del Muro X, Villanueva A: Nude mice model of primary human nonseminoma germ cell tumors to study biology and resistance to cisplatin treatment. J Clin Oncol; 2009 May 20;27(15_suppl):e16143

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nude mice model of primary human nonseminoma germ cell tumors to study biology and resistance to cisplatin treatment.
  • : e16143 Testicular germ cell tumors (TGCTs) are the most common malignancy in young men.
  • Recently, our group has reported the development of a model of human nonseminoma (NSE) after orthotopic nude mice implantation (Piulats et al, Amer Assoc Cancer Res. 2006).
  • Pure and mix NSE anatomies were represented and they reproduce the main histological, genetic and epigenetic characteristics of paired primary tumors.
  • Xenografts mimic distal dissemination patterns and cisplatin (CDDP) tumor behavior responses.
  • We have generated in vivo five tumors showing increased resistance to CDDP by exposition to repetitive cycles and increasing the dose applied through different passages (1 yolk-sac; 1 choriocarcinoma; 2 embrional carcinoma; 1 mix tumor).
  • A shortness time elipse between pasajes was observed for each tumor through CDDP treatments.
  • To confirm increasin resistance, a parallel assay of chemotherapy response was performed between nontreated and CDDP resistant tumors.
  • Whole genome analysis of tour xenografted tumors and their paired CDDP resistant tumor (#3 and #5 passage) were analyzed by CGH NimbeGen arrays using 60 Kb average windows.
  • Few differential genomic changes were identified some of them were consistent across resistant tumors including gain of 9q21.11-9q33.3, 15q23-15q24.1, and 15q26.3 regions and loss of Xp22.33.
  • In one tumour showing strong CDDP resistance compared with its sensitive counterpart it occur in absence of new genomic changes.
  • No changes in the MSI or mutational TP53 status were observed in resisant tumors.
  • Our data suggest that acquisition of tumor resistance to CDDP in TGCTs may proably depend of a combination of different mechanisms, including cromosomal imbalances.

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  • (PMID = 27963427.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Vicioso L, Gallego E, Sanz A: Cutaneous mixed tumor with lipomatous stroma. J Cutan Pathol; 2006 Sep;33 Suppl 2:35-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous mixed tumor with lipomatous stroma.
  • AIM: Mixed tumors are usually composed of two components, one epithelial and the other mesenchymal.
  • To date, only two cases of mixed tumor of the skin have been reported with this type of stroma.
  • METHODS AND RESULTS: We report the case of a 61-year-old man with a mixed tumor situated on the hand, an unusual site for these tumors, with over 90% of the tumor composed of adipose tissue.
  • The tumor was a well-circumscribed, 4.5-cm mass, with the gross appearance of a lipoma.
  • Immunohistochemical study showed findings similar to those seen in classic mixed tumors.
  • CONCLUSION: Together with a few other cases in the skin and parotid gland, this report shows how massive adipose differentiation can arise in a mixed tumor of the skin.
  • [MeSH-major] Adipose Tissue / pathology. Fibroma / pathology. Mixed Tumor, Malignant / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972952.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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16. Urbaniec P, Namysłowski G, Lange D, Urbaniec N: [Pleomorphic adenoma of the nasal septum]. Otolaryngol Pol; 2005;59(3):425-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic adenoma of the nasal septum].
  • [Transliterated title] Gruczolak wielopostaciowy przegrody nosa.
  • The authors described the case of mixed salivary gland tumour in the nasal septum.
  • [MeSH-major] Adenoma, Pleomorphic. Nasal Septum / pathology. Nose Neoplasms

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  • (PMID = 16117402.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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17. Kandasamy J, Smith A, Diaz S, Rose B, O'Brien C: Heterogeneity of PLAG1 gene rearrangements in pleomorphic adenoma. Cancer Genet Cytogenet; 2007 Aug;177(1):1-5
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  • [Title] Heterogeneity of PLAG1 gene rearrangements in pleomorphic adenoma.
  • Pleomorphic adenoma (PA), a benign mixed salivary gland tumor, has been associated with abnormal karyotypes in up to 70% of cases, with nonrandom involvement of 8q12, the locus of the pleomorphic adenoma (PLAG1) gene.
  • Samples of parotid gland tissue from the tumor sites, set up as solid tumor cultures, showed a normal karyotype in two cases [46,XY;46,XX] and cytogenetic abnormalities in five cases (71%).
  • In addition, genomic instability was seen in two cases, one with PLAG1 amplification in the form of a homogeneously staining region, and the other in der(8) ring formation.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. DNA-Binding Proteins / genetics. Gene Rearrangement. Genetic Variation. Salivary Gland Neoplasms / genetics

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  • (PMID = 17693184.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human
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18. Steele NP, Wenig BM, Sessions RB: A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node. Am J Otolaryngol; 2007 Mar-Apr;28(2):130-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.
  • OBJECTIVE: Pleomorphic adenomas are the most common salivary gland tumors and are typically cured with complete surgical excision.
  • There are rare reports, however, in which these histologically benign tumors have inexplicably metastasized to distant sites.
  • We present a case of a patient who presented, 27 years after excision of a parotid pleomorphic adenoma, with a recurrence in the parotid bed and a mediastinal metastasis.
  • METHODS: A 43-year-old woman presented with a mass in the right parotid bed 27 years after excision of a pleomorphic adenoma of the parotid.
  • The patient's presentation, workup, and final diagnosis of benign metastasizing pleomorphic adenoma will be discussed, along with a pertinent review of the literature.
  • RESULTS: A diagnosis of recurrent pleomorphic adenoma was made from a fine needle aspiration biopsy of the right parotid mass.
  • On subsequent computed tomographic scan, chest images revealed an incidental left mediastinal mass, which also proved to be a pleomorphic adenoma on computed tomography-guided fine needle aspiration biopsy.
  • Examination of the pathology specimens confirmed a diagnosis of pleomorphic adenoma in both the parotid bed and the mediastinum.
  • No histologic characteristics of malignancy were seen in either specimen; therefore, a diagnosis of benign metastasizing mixed tumor was rendered.
  • CONCLUSION: Benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity.
  • Although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasize to distant sites.
  • It remains to be determined whether these benign metastasizing pleomorphic adenomas are really low-grade salivary malignancies.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17362821.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Chimona TS, Koutsopoulos AV, Malliotakis P, Nikolidakis A, Skoulakis C, Bizakis JG: Malignant mixed tumor of the nasal cavity. Auris Nasus Larynx; 2006 Mar;33(1):63-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant mixed tumor of the nasal cavity.
  • Parotid gland is the most common location of malignant mixed tumors.
  • Three different subtypes of these tumors exist: carcinoma ex pleomorphic adenoma, carcinosarcoma, and metastasizing mixed tumor.
  • Carcinoma ex-pleomorphic adenoma is by far the most common subtype.
  • Although unusual sites of these tumors have been published, we report an extremely rare case of a malignant mixed tumor located in the nasal cavity.
  • [MeSH-major] Mixed Tumor, Malignant / pathology. Nasal Cavity / pathology. Nose Neoplasms / pathology

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  • (PMID = 16188415.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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20. Mebazaa A, Trabelsi S, Denguezli M, Sriha B, Belajouza C, Nouira R: Chondroid syringoma of the arm: an unusual localization. Dermatol Online J; 2006;12(1):14
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  • [Title] Chondroid syringoma of the arm: an unusual localization.
  • Chondroid syringoma (CS) is an uncommon, benign, sweat-gland tumor.
  • We present a case of a CS located in the right arm of a 43-year-old woman.
  • This tumor developed slowly over 8 years.
  • The diagnosis of CS was made by histopathological examination; it showed an abundant chondroid stroma intermingled with a fibro-adipoid tissue.
  • There was no recurrence after total excision of the tumor with a 2-year followup.
  • The unusual localization of chondroid syringoma made an accurate preoperative diagnosis difficult and diagnosis was achieved only by microscopy.
  • Surgical tumor excision remains the best therapeutic option to avoid relapses of this tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Arm. Sweat Gland Neoplasms / pathology

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  • (PMID = 16638382.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Nowak K: [Carcinosarcoma arising from a preexisting pleomorphic adenoma--true malignant mixed tumor of the parotid gland]. Otolaryngol Pol; 2007;61(6):1024-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinosarcoma arising from a preexisting pleomorphic adenoma--true malignant mixed tumor of the parotid gland].
  • [Transliterated title] Miesakorak rozwijajacy sie w obrebie gruczolaka wielopostaciowego--"prawdziwy" zlośliwy guz mieszany ślinianki przyusznej.
  • Carcinosarcoma (true malignant mixed tumor) is rare in salivary gland neoplasms.
  • Even rarer is a carcinosarcoma arising from a preexisting pleomorphic adenoma.
  • Computed tomography and USG-examination revealed a mass originating from left parotid gland.
  • Clinical and histologic date revealed it had developed from a preexisting pleomorphic adenoma.
  • This tumor seemed to consist of two histogenetically different populations of cells.
  • We also review the literature and dicuss the histogenetic origin of the carcinosarcoma of salivary gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinosarcoma / pathology. Mixed Tumor, Malignant / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18546958.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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22. Eladioui K, Ntima A, Noublanche P, Cucherousset N, Attar A: [Metastasis of a pleomorphic adenoma]. Rev Stomatol Chir Maxillofac; 2008 Jun;109(3):191-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastasis of a pleomorphic adenoma].
  • OBSERVATION: A 53-year-old man underwent a right parotidectomy in 1993 for a pleomorphic adenoma.
  • The tumor relapsed locally, three years later, imposing a reoperation.
  • Two years later, the excision of a new local recurrence revealed a histological evolution with intravascular emboli, some cellular atypia and some mitoses.
  • The patient died of a cerebral hemorrhage related to a history of familial autoimmune thrombocytopenia.
  • DISCUSSION: Regional and systemic metastases of pleomorphic adenomas are exceptional.
  • The local recurrence is characteristic of metastatic forms of pleomorphic adenomas; it occurs in 90% of the cases.
  • No clinical or histological criterion allows distinguishing between recurrent metastatic forms and non-recurrent metastatic pleomorphic adenomas.
  • The best treatment for metastases of a pleomorphic adenoma is surgical excision.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology. Skull Neoplasms / secondary

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  • (PMID = 18533212.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. Sivamani R, Wadhera A, Craig E: Chondroid syringoma: case report and review of the literature. Dermatol Online J; 2006;12(5):8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma: case report and review of the literature.
  • The lesion had been excised 4 years prior and was diagnosed as chondroid syringoma, but had gradually regrown.
  • Histopathological examination was again consistent with chondroid syringoma, and showed the following:.
  • 1) a chondroid matrix, 2) tubuloalveolar structures lined by a double epithelium, 3) ductal structures lined by a single epithelium, 4) nests of polygonal cells, and 5) the presence of keratinous cysts.
  • Chondroid syringoma is a rare mixed tumor of the skin that was first described by Hirsch and Helwig.
  • Characteristically, it is composed of a proliferation of epithelial cells set in a myxoid and chondroid matrix.
  • Although chondroid syringomas are predominantly benign, malignant forms have been reported.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Facial Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16962023.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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24. Kerimoglu U, Aydingoz U, Ozkaya O, Aksu AE, Ergen FB: MRI of a benign chondroid syringoma. Br J Radiol; 2006 Aug;79(944):e59-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of a benign chondroid syringoma.
  • Chondroid syringoma, also known as mixed tumour of the skin, is a relatively rare, usually benign tumour.
  • A few malignant cases, especially in the lower extremities, have been published, but most of them behave in a benign fashion.
  • A case of a middle-aged woman with surgically proved chondroid syringoma in the pretibial region is presented in this report with MRI and histological findings.
  • Despite rapid growth over a short period of time and a location reportedly associated with malignancy, the histological features were benign.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16861320.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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25. Turhan-Haktanir N, Sahin O, Bukulmez A, Demir Y: Chondroid syringoma in a child. Pediatr Dermatol; 2007 Sep-Oct;24(5):505-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma in a child.
  • Chondroid syringoma is a myxoid tumor of the skin, which has a reported incidence of <0.01% among primary skin tumors.
  • The majority of these tumors occur in the head and neck regions of adult males.
  • We present the first instance of chondroid syringoma in a child, which, to the best of our knowledge, has not been reported previously in the English language literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Nose Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17958797.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Nath AK, Kumari R, Thappa DM: Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution. Indian J Dermatol Venereol Leprol; 2009 Nov-Dec;75(6):600-2
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  • [Title] Eccrine spiradenoma with chondroid syringoma in Blaschkoid distribution.
  • It may be associated with foci of various other appendageal tumors.
  • Histopathology revealed dermal lobules of ES with smaller foci of chondroid syringoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19915242.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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27. Tamiolakis D, Chimona TS, Georgiou G, Proimos E, Nikolaidou S, Perogamvrakis G, Papadakis CE: Accessory parotid gland carcinoma ex pleomorphic adenoma. Case study diagnosed by fine needle aspiration. Stomatologija; 2009;11(1):37-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accessory parotid gland carcinoma ex pleomorphic adenoma. Case study diagnosed by fine needle aspiration.
  • OBJECTIVE: The accessory parotid gland is salivary tissue separated from the main parotid gland and lying on masseter muscle.
  • The accessory parotid gland exists in 21-61% of individuals.
  • However, the appearance of an accessory parotid tumor is rare, with a reported frequency of 1-7.7% of all parotid gland tumors.
  • Carcinoma ex pleomorphic adenoma arises from a pre-existing benign mixed tumor.
  • Most of these tumors will have malignant epithelial component, but not malignant stromal component.
  • Reports of Fine Needle Aspiration Cytological (FNAC) diagnosis of malignant mixed tumor are uncommon and have been limited to cases arising in the parotid.
  • We report a case of carcinoma ex pleomorphic adenoma of the accessory lobe of the parotid, and address the cytopathology features and pitfalls of this condition.
  • FNA was performed and the smears demonstrated features indicative of pleomorphic adenoma admixed with findings indicative of a poorly differentiated carcinoma.
  • CONCLUSION: FNAC can accurately diagnose carcinoma ex pleomorphic adenoma when strongly fixed requirements are implemented.

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  • (PMID = 19423970.001).
  • [ISSN] 1392-8589
  • [Journal-full-title] Stomatologija
  • [ISO-abbreviation] Stomatologija
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Lithuania
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28. Tokyol C, Aktepe F, Yavas BD, Yildiz H, Aycicek A: Chondroid syringoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):973-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma: a case report.
  • BACKGROUND: Chondroid syringoma is a benign skin adnexal tumor.
  • The reported incidence of chondroid syringoma among primary skin tumors is low and has been reported at 0.01-0.098%.
  • CASE: A 57-year-old woman presented with a 10-year history of a slowly growing lump on her philtrum.
  • A diagnosis of benign appendageal tumor of the skin was made.
  • Surgical excision of tumor was done.
  • Histopathologic examination was consistent with chondroid syringoma.
  • CONCLUSION: Chondroid syringoma should be included in the differential diagnosis of a slowly growing nodule on the head or neck.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lip Neoplasms / pathology

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  • (PMID = 21053580.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Magalhães E, Eugénio L, Bernardo J, Carvalho L, Antunes M: [Pleomorphic adenoma of the trachea. Case report]. Rev Port Pneumol; 2006 Mar-Apr;12(2):177-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic adenoma of the trachea. Case report].
  • [Transliterated title] Adenoma pleomórfico da traqueia. Caso clínico.
  • The authors present a case of a pleomorphic adenoma of the trachea, diagnosed during the clinical evaluation of a suspected COPD or lung cancer in a heavy smoker patient with a positive family history of oncologic diseases.
  • The patient underwent segmental resection of the trachea with complete excision of the tumour, and a good prognosis is anticipated.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Tracheal Neoplasms / surgery

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  • (PMID = 16804633.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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30. Varsori M, Dettwiler S, Chaloupka K: [Eyelid chondroid syringoma: a case report]. J Fr Ophtalmol; 2007 Jan;30(1):e3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Eyelid chondroid syringoma: a case report].
  • [Transliterated title] Syringome chondroïde de la paupière: à propos d'un cas.
  • Chondroid syringoma is a rare benign skin tumor of the head and neck.
  • The lesion was surgically removed, and the histopathological examination showed a chondroid syringoma.
  • Knowledge of this disease is important because malignant transformations do occur.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eyelid Neoplasms / diagnosis

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  • (PMID = 17287665.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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31. Shimosawa H, Susa M, Honma T, Hiraishi E, Sakihara H: Soft tissue mixed tumor of the hand. Rare Tumors; 2009;1(2):e30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Soft tissue mixed tumor of the hand.
  • Mixed tumors are relatively common in the skin and salivary glands, but extremely rare in soft tissues, often resulting in diagnostic problems.
  • The occurrence of these tumors in the hand is especially limited.
  • In this article we report the clinical, radiological, and histological features of a mixed tumor of the hypothenar region of the right hand.

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  • (PMID = 21139909.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994479
  • [Keywords] NOTNLM ; hand / immunohistochemistry. / mixed tumor / soft tissue
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32. Rauso R, Santagata M, Tartaro G, Filipi M, Colella G: Chondroid syringoma: a rare tumor of orofacial region. Minerva Stomatol; 2009 Jul-Aug;58(7-8):383-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma: a rare tumor of orofacial region.
  • Chondroid syringoma is a rare tumor arising from the major and minor salivary glands.
  • The incidence of chondroid syringoma is reported to be <0.01% among the primary skin tumors.
  • Eighty percent of the chondroid syringomas are seen in older patients , commonly on head and neck region and mostly on the cheek and nose.
  • The authors report a case discussing the surgical management of a chondroid syringoma and pointing out the importance of including this tumor in the differential diagnosis of small subcutaneous nodules in the head and neck region, in middle-age male patients.
  • [MeSH-major] Adenoma, Pleomorphic. Facial Neoplasms. Mouth Neoplasms

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  • (PMID = 19633639.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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33. Sirivella S, Gielchinsky I: Chondroid syringoma: a rare tumor of the chest wall. Ann Thorac Surg; 2010 Mar;89(3):983-5
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  • [Title] Chondroid syringoma: a rare tumor of the chest wall.
  • Chondroid syringoma, an uncommon, slow-growing, benign, sweat-gland tumor located on the upper right chest wall of a 66-year-old woman is presented.
  • This skin adenexal tumor is typically located on the head and neck region.
  • The unusual location of chondroid syringoma made an accurate preoperative diagnosis difficult, and diagnosis was achieved only by excisional biopsy and histopathologic examination.
  • Total surgical excision remains the best therapeutic option to avoid tumor recurrence and close follow-up is recommended because of a rare possibility of malignant transformation and visceral metastases.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172178.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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34. Choudhury M, Agarwal C, Aggarwal M, Pathania OP, Goel N: Clinicopathological profile of an unusual case of chondroid syringoma: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):349-51
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  • [Title] Clinicopathological profile of an unusual case of chondroid syringoma: a case report.
  • Chondroid syringoma or mixed tumor of the skin is an uncommon tumor that typically presents as small, solitary, slow growing, firm, subcutaneous or intracutaneous nodule.
  • FNAC and excision biopsy revealed benign chondroid syringoma.
  • This is a rare case of chondroid syringoma exhibiting large size, multiplicity and unusual locations in flank, chest wall and thigh.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17883069.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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35. Karnwal A, Pakalapati S, Tzifa K, Raut V: Chondroid syringoma of the external ear canal presenting as a cyst. Kulak Burun Bogaz Ihtis Derg; 2006;16(2):80-2
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  • [Title] Chondroid syringoma of the external ear canal presenting as a cyst.
  • Chondroid syringoma of the external ear canal is a rare, usually firm or polypoid tumor, representing the cutaneous counterpart of pleomorphic adenoma of salivary glands.
  • We report a very rare case of chondroid syringoma in a 40-year-old man who presented with a fluid-containing cyst in the external ear canal.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ear Neoplasms / diagnosis. Ear, External / pathology

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  • (PMID = 16763421.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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36. Hafezi-Bakhtiari S, Al-Habeeb A, Ghazarian D: Benign mixed tumor of the skin, hypercellular variant: a case report. J Cutan Pathol; 2010 Sep;37(9):e46-9
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  • [Title] Benign mixed tumor of the skin, hypercellular variant: a case report.
  • Microscopic examination showed a well-circumscribed dermally located tumor composed of ductal elements lined by double to multiple cell layers of bland cuboidal inner cells and elongated spindled outer cells with areas showing cribriform and solid growth patterns.
  • The overall morphology and immunohistochemical profile are that of a benign cutanoues mixed tumor (chondroid syringoma).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cell Nucleus / pathology. Diagnosis, Differential. Epidermal Cyst / diagnosis. Humans. Immunohistochemistry. Male. Scalp

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  • (PMID = 19614993.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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37. Bekler H, Gokce A, Beyzadeoglu T: Chondroid syringoma of the hand: a rare localization. Handchir Mikrochir Plast Chir; 2007 Dec;39(6):430-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma of the hand: a rare localization.
  • Chondroid syringoma is a rare benign neoplasm of the sweat glands that usually occurs in the head and neck region.
  • We describe a 18-year-old male patient with a benign chondroid syringoma that occurred at an unusual site, leading to compression symptoms of the ulnar nerve causing symptoms at the hypothenar region of the right hand.
  • Although it is a rare tumor at an unusual site, it should be included in the differential diagnosis of the hand tumors.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 18058676.001).
  • [ISSN] 0722-1819
  • [Journal-full-title] Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
  • [ISO-abbreviation] Handchir Mikrochir Plast Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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38. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Title] [Chondroid syringoma: a clinical and histological review of eight cases].
  • [Transliterated title] Siringoma condroide: revisión clínica e histológica de ocho casos.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • MATERIAL AND METHODS: Eight cases diagnosed of chondroid syringoma in our Department in the last eight years were reevaluated clinically and histologically and the epiluminiscence microscopy was used in one of them.
  • All the cases had a myxoid matrix and most also had a chondroid one.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • The microscopic examination of these lesions reveals tubuloalveolar and glandular type structures positioned as islets within a fibroadipose, chondroid, myxoid or hyaline stroma.
  • The final treatment of these tumors is surgical.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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39. Kumar B: Chondroid syringoma diagnosed by fine needle aspiration cytology. Diagn Cytopathol; 2010 Jan;38(1):38-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma diagnosed by fine needle aspiration cytology.
  • Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region.
  • It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components.
  • There are only few case reports describing the fine needle aspiration cytologic features of chondroid syringoma for diagnosis.
  • On the basis of these cytologic features, a diagnosis of chondroid syringoma was made.
  • We concluded that Chondroid syringoma may be considered as a rare differential diagnosis in the swelling of head and neck region and the diagnosis can be easily confirmed or ruled out by means of fine needle aspiration cytology.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19693940.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Constantinescu MB, Chan JB, Cassarino DS: Chondroid syringoma with tyrosine crystals: case report and review of the literature. Am J Dermatopathol; 2010 Apr;32(2):171-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chondroid syringoma with tyrosine crystals: case report and review of the literature.
  • Chondroid syringoma (CS) is a relatively rare cutaneous mixed tumor arising from sweat glands.
  • CSs share morphologic similarities with their salivary gland counterparts, pleomorphic adenomas (benign mixed tumors).
  • Although the presence of tyrosine-rich crystalloids in mixed tumors of the salivary gland is well recognized, to our knowledge, this finding has not been previously described in mixed tumors of the skin.
  • [MeSH-major] Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / metabolism. Syringoma / diagnosis. Syringoma / metabolism. Tyrosine / metabolism

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  • (PMID = 19851085.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 42HK56048U / Tyrosine
  • [Number-of-references] 29
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41. Kaushik V, Bhalla RK, Nicholson C, de Carpentier JP: The chondroid syringoma: report of a case arising from the external auditory canal. Eur Arch Otorhinolaryngol; 2005 Oct;262(10):868-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The chondroid syringoma: report of a case arising from the external auditory canal.
  • Chondroid syringoma is an uncommon, benign skin adnexal tumour.
  • A rare case of chondroid syringoma arising from the external auditory canal is reported.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ear Canal. Ear Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • [Cites] Am J Clin Oncol. 2000 Jun;23(3):227-32 [10857882.001]
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  • (PMID = 15739085.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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42. Magro G, Floridia F, Geraci G, Marino B: Lipomatous apocrine mixed tumor of the skin: an unusual giant lesion occurring in the breast. J Cutan Pathol; 2009 Jun;36(6):692-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipomatous apocrine mixed tumor of the skin: an unusual giant lesion occurring in the breast.
  • Cutaneous mixed tumors (MTs), also known as chondroid syringomas, usually arise as small nodules in the head and neck region.
  • We describe an unusual case of a giant MT measuring 9 cm in its greatest diameter, occurring as a slowly growing pedunculated mass on the breast of a 74-year-old woman.
  • Apart this unusual clinical presentation, another intriguing feature of tumor was the histological picture, being composed of an extensive mature fatty stromal component closely intermingling with the epithelial structures.
  • As adipocytes were variable in size and focally showed a lipoblast-like appearance, some tumor areas were reminiscent of a well-differentiated liposarcoma, lipoma-like.
  • Based on the histological features, the term 'lipomatous mixed tumor, apocrine type' was proposed for such a lesion.
  • Histogenetic considerations about the lipomatous stromal component of the tumor are provided.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology. Lipoma / pathology. Neoplasms, Complex and Mixed / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Alzheimer Disease / complications. Female. Humans

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  • (PMID = 19515050.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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43. Hernández Sandemetrio R, Armengot Carceller M, Alba García JR, Taleb C, Jiménez Roig JP, Frías Moya-Angeler S, Basterra Alegría J: [Pleomorphic adenoma of deep lobe of the parotid gland]. Acta Otorrinolaringol Esp; 2006 Jan;57(1):56-8

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  • [Title] [Pleomorphic adenoma of deep lobe of the parotid gland].
  • [Transliterated title] Adenoma pleomorfo gigante de lóbulo profundo de la parótida: a propósito de un caso.
  • Parapharyngeal space tumors are rare.
  • Salivary neoplasms being the most frequent ones.
  • This report describes a case of a pleomorphic adenoma in the deep lobe of the parotid gland presented like a parapharyngeal mass, and its diagnosis and treatment.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16503035.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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44. Kim H, Nakaichi M, Itamoto K, Taura Y: Malignant mixed tumor in the salivary gland of a cat. J Vet Sci; 2008 Sep;9(3):331-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant mixed tumor in the salivary gland of a cat.
  • The presence of a malignant mixed tumor, also known as a carcinosarcoma, in the salivary gland is very rare.
  • Such tumors, which are typically aggressive, are characterized by the presence of carcinomatous and sarcomatous components.
  • Histopathological analysis of the mass revealed that it was a malignant mixed tumor.
  • [MeSH-major] Adenocarcinoma / veterinary. Cat Diseases / pathology. Cat Diseases / radiography. Chondrosarcoma / veterinary. Salivary Gland Neoplasms / veterinary

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  • (PMID = 18716455.001).
  • [ISSN] 1229-845X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2811847
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45. Skoro M, Ostović KT, Cikara I, Müller D, Novak NP, Virag M: Fine needle aspiration cytology of chondroid syringoma. Coll Antropol; 2010 Jun;34(2):687-90
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  • [Title] Fine needle aspiration cytology of chondroid syringoma.
  • Chondroid syringoma (CS) is a rare, benign, appendageal tumor with diagnostic feature of myxochondroid stroma supporting eccrine and apocrine epithelial structures.
  • It should be included in the differential diagnosis of cutaneous head and neck tumors, especially in middle-aged men.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Head and Neck Neoplasms / pathology

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  • (PMID = 20698155.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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46. Chaari C, Ellouze S, Chamli H, Krichen Makni S, Karray F, Sellami Boudawara T: [Squamous cell carcinoma on a pleomorphic adenoma with amyloid stroma of the palate]. Rev Stomatol Chir Maxillofac; 2010 Feb;111(1):53-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Squamous cell carcinoma on a pleomorphic adenoma with amyloid stroma of the palate].
  • INTRODUCTION: Squamous cell carcinoma ex-pleomorphic adenoma (CXAP) is a malignant and rare mixed tumor.
  • The physical examination revealed a hard and large tumor invading all the palate.
  • A histological study confirmed the diagnosis after surgical resection of the tumor, specifying its noninvasive character.
  • DISCUSSION: CXAP is generally located in the parotid gland; it is very rarely located in the palate.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Amyloid / analysis. Carcinoma, Squamous Cell / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology

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  • (PMID = 19932498.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Amyloid; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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47. Gündüz K, Demirel S, Heper AO, Günalp I: A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature. Surv Ophthalmol; 2006 May-Jun;51(3):280-5
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  • [Title] A rare case of atypical chondroid syringoma of the lower eyelid and review of the literature.
  • Histopathologic and immunohistochemical findings were consistent with atypical chondroid syringoma with eccrine differentiation.
  • Chondroid syringoma is a rare skin tumor that occurs, very rarely, in the eyelids, especially the lower eyelid.
  • Only 26 cases of chondroid syringoma in the periorbital area, including our case, have been reported, with various characteristics.
  • Chondroid syringomas are classified as two types, the apocrine type characterized by tubular and cystic branching lumina lined by two layers of epithelial cells, and the eccrine type, which has small tubular lumina lined by a single layer of epithelial cells.
  • The tumor can have benign, atypical, and malignant variants.
  • Our patient had the atypical variant, which is characterized by benign cytological features, as well as the presence of infiltrative margins and/or satellite nodules.
  • Even benign chondroid syringomas, if incompletely excised, can recur with malignant transformation; thus, complete excision and regular follow-up is recommended for all chondroid syringomas.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Eyelid Neoplasms / pathology

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  • (PMID = 16644368.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Kakitsubata Y, Theodorou SJ, Theodorou DJ, Nakahara M, Yuki Y, Yokouchi T: Giant chondroid syringoma presenting as a growing subcutaneous mass in the upper arm: MRI findings with pathologic correlation. Joint Bone Spine; 2009 Dec;76(6):711-4
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  • [Title] Giant chondroid syringoma presenting as a growing subcutaneous mass in the upper arm: MRI findings with pathologic correlation.
  • Chondroid syringoma of skin is a rare type of soft tissue tumor originating from the sweat glands.
  • We report a documented case of giant chondroid syringoma occurring in the upper arm, which developed over the course of one year.
  • The radiographic, sonographic, MR imaging, gross pathologic, and histologic findings of the tumor are described.
  • Because the clinical suggestion of such a tumor was low, we present the imaging appearances of chondroid syringoma that could be used to make a presumptive diagnosis, and discuss the many entertained differential diagnostic possibilities.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Magnetic Resonance Imaging / methods. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19793672.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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49. Khadse P, Prabhash K, Pramesh CS, Chaturvedi P, Shet T: Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma. Diagn Cytopathol; 2009 Sep;37(9):680-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma.
  • Malignant mixed tumor of the parotid is known to have odd sites for metastases.
  • We describe the fine-needle aspiration cytology (FNAC) findings of pleural metastasis from a malignant mixed tumor misdiagnosed as a mesothelioma on cytology at the onset.A 47-year-old man presented to us with breathlessness and a massive pleural effusion with pleural-based nodules.
  • He had been operated 2 years before for a pleomorphic adenoma of the parotid and had a healthy scar at that site.
  • These cells in contrast to the usual mesothelial cells were not arranged in sheets but rather were huddled in places and formed a pseudoacinar pattern and blended with the myxoid substance.After the diagnosis of a mesothelioma, patient received pemetrexed and cisplatin based chemotherapy with partial response.
  • While on chemotherapy tumor recurred at the primary site in parotid and was confirmed to be a carcinosarcoma on a FNAC and biopsy.To conclude, pleural metastases from a true malignant mixed tumor of the parotid gland can be misdiagnosed as mesothelioma and could occur in the absence of uncontrolled disease at primary site.
  • Both mesotheliomas and pleomorphic adenomas metastatic to the pleura are biphasic tumors, but in a patient with history of pleomorphic adenoma, the latter should be kept as a foremost possibility.
  • Attention to the cytomorphology of tumor cells will also assist in confirming the diagnosis.
  • [MeSH-major] Carcinosarcoma / secondary. Mesothelioma / pathology. Neoplasms, Complex and Mixed / secondary. Parotid Neoplasms / pathology. Pleural Neoplasms / secondary

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19373913.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; Q20Q21Q62J / Cisplatin
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50. Ceylan A, Celenk F, Poyraz A, Uslu S: Pleomorphic adenoma of the nasal columella. Pathol Res Pract; 2008;204(4):273-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the nasal columella.
  • Pleomorphic adenoma (mixed tumor) is the most common benign neoplasm of the salivary glands.
  • It is considered to occur primarily in the major salivary glands, such as the parotid and submandibular glands.
  • It is much less common in the minor salivary glands, and rarely occurs at other sites, such as larynx, pharynx, trachea, lacrimal gland, and sinonasal tract.
  • We describe a very rare case of recurrent pleomorphic adenoma originating from the columella.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local. Neoplasm Seeding. Nose Neoplasms / pathology

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  • (PMID = 18295980.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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51. Palomar Asenjo V, Borràs Perera M, Soteras Ollé J, Palomar García V: [Parotid gland myoepitheliomas. Differential diagnosis with pleomorphic adenoma]. An Otorrinolaringol Ibero Am; 2006;33(4):409-16

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  • [Title] [Parotid gland myoepitheliomas. Differential diagnosis with pleomorphic adenoma].
  • [Transliterated title] Mioepiteliomas de glándula parótida. Diagnóstico diferencial con el adenoma pleomorfo.
  • Myoepitheliomas are rare benign tumours of head and neck.
  • The parotid gland is the most common site of origin.
  • It consists on proliferation of myoepithelial cells and it shows some features similar to preomorphic adenoma although the ductal elements are very low.
  • We report two cases of parotid gland myoepithelioma confirmed by immunohistochemistry.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Myoepithelioma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16910397.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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52. El Fakiri MM, Aderdour L, Nouri H, Hassani R, Maliki O, Raji A: [Pleomorphic adenoma of the nasal septum]. Rev Stomatol Chir Maxillofac; 2010 Jun;111(3):162-4
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  • [Title] [Pleomorphic adenoma of the nasal septum].
  • INTRODUCTION: The pleomorphic adenoma is the most common benign neoplasm of primary salivary glands.
  • We report a case of pleomorphic adenoma of the nasal septum.
  • A facial CT-scan showed a heterogeneous tumor of the nasal septum obstructing the left nasal vestibule.
  • The biopsy analysis proved the histological characteristics of a pleomorphic adenoma, and was further confirmed by immunohistochemical study.
  • DISCUSSION: The treatment of nasal pleomorphic adenomas must take into account lesion localization, esthetic complications, and evolutionary potential of the lesions.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Nasal Septum / pathology. Nose Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20416914.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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53. Schmidt LA, Olsen SH, McHugh JB: Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy. Am J Surg Pathol; 2010 Aug;34(8):1205-10
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  • [Title] Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy.
  • Cutaneous adnexal differentiation is well-recognized in benign mixed tumors occurring in cutaneous sites.
  • The incidence of this histologic finding in salivary gland sites is not known.
  • We sought to describe the incidence of cutaneous adnexal differentiation in benign mixed tumors of the palate, lip, and parotid gland.
  • Benign mixed tumors of the palate (n=30), lip (n=13), and parotid gland (n=37) resected between 1980 and 2009 at a single academic medical institution were reviewed.
  • After confirming the diagnosis of benign mixed tumor, we evaluated for morphologic evidence of cutaneous adnexal differentiation and metaplastic epithelial and stromal changes.
  • Cutaneous adnexal differentiation was seen in 20% of palate and 39% of lip benign mixed tumors but in no parotid tumors.
  • The most frequent features of cutaneous adnexal differentiation were tricholemmal differentiation (20% of palate and 39% of lip tumors), infundibulocystic structures (17% and 31%), and trichohyalin granules (13% and 31%).
  • Sebaceous differentiation was seen in only one palate tumor.
  • Varying amounts of stromal adipose were seen in 62, 37, and 22% of lip, palate, and parotid tumors.
  • Osseous metaplasia was seen in one tumor from each site.
  • When cutaneous adnexal differentiation occurs in salivary gland pleomorphic adenomas, it can present a diagnostic pitfall that must not be misinterpreted as carcinoma at biopsy, fine needle aspiration, or frozen section.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Cell Differentiation. Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Mouth Neoplasms / pathology. Stromal Cells / pathology

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  • (PMID = 20661019.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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54. Honda T, Yamamoto Y, Isago T, Nakazawa H, Nozaki M, Hirayama T: Giant pleomorphic adenoma of the parotid gland with malignant transformation. Ann Plast Surg; 2005 Nov;55(5):524-7

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  • [Title] Giant pleomorphic adenoma of the parotid gland with malignant transformation.
  • A 72-year-old female is described who was admitted to the hospital with a giant mixed tumor of the left parotid gland that had grown to a weight of 6051 g within 20 years and ultimately underwent resection of the mass.
  • Histopathological examination revealed adenocarcinoma cells with hyperchromatic nuclei and mitotic figures proliferated in pleomorphic adenoma.
  • Many authors have reported giant tumors weighing more than a few kilograms of the parotid glands, and most were benign.
  • The present tumor was the sixth largest among all the parotid tumors, including both benign and malignant, which were reported.
  • The tumor was successfully resected with no marked facial nerve paralysis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Cell Transformation, Neoplastic / pathology. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 16258307.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Kajor M, Gierek T, Markowski J, Pajak J: Schwannomalike mixed tumor of the parotid gland: a case report. Acta Cytol; 2006 Sep-Oct;50(5):529-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schwannomalike mixed tumor of the parotid gland: a case report.
  • BACKGROUND: Schwannomalike mixed tumor is a rare benign tumor of the parotid glands.
  • CASE: A 75-year-old woman presented with a tumor 3 cm in diameter localized in her left parotid gland.
  • Morphologic examinations were performed.
  • CONCLUSION: FNA cytology was very useful in the diagnosis of this rare tumor of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Neurilemmoma / diagnosis. Parotid Gland / pathology. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Diagnosis, Differential. Digestive System Surgical Procedures. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Predictive Value of Tests. Schwann Cells / metabolism. Schwann Cells / pathology. Treatment Outcome

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  • (PMID = 17017438.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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56. Kazakov DV, Belousova IE, Bisceglia M, Calonje E, Emberger M, Grayson W, Hantschke M, Kempf W, Kutzner H, Michal M, Spagnolo DV, Virolainen S, Zelger B: Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases. J Am Acad Dermatol; 2007 Sep;57(3):467-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases.
  • BACKGROUND: A systematic analysis of the entire spectrum of various forms of differentiation and metaplastic epiphenomena in cutaneous apocrine mixed tumor (AMT) has never been performed.
  • OBJECTIVE: The purpose of our study was to study a large number of cutaneous mixed tumors so as to fully characterize the entire spectrum of differentiations and metaplastic changes that may occur in the epithelial, myoepithelial, and stromal components of AMT.
  • Stromal alterations included chondroid metaplasia, osseous metaplasia, and adipose metaplasia.
  • We propose that the most appropriate name for these lesions is "mixed tumor of the folliculosebaceous-apocrine complex. "
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Apocrine Glands. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17707152.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 104
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57. Gedlicka C, Item CB, Wögerbauer M, Martinek H, Heiduschka G, Erovic BM, Ch Grasl M, Thurnher D: Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations. J Surg Oncol; 2010 Feb 1;101(2):127-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations.
  • BACKGROUND AND OBJECTIVES: This retrospective study was performed to evaluate the status of p53 in pleomorphic adenomas and carcinomas ex pleomorphic adenoma in the parotid gland.
  • As loss or mutation of p53 can cause malignant transformation, the possible degeneration of pleomorphic adenomas to carcinomas ex pleomorhic adenoma was investigated by mutational analysis.
  • METHODS: Twenty-five Patients including 14 patients with pleomorphic adenomas and 11 patients with carcinoma ex pleomorphic adenoma of the parotid gland were examined for p53 status.
  • Denaturing gradient gel electrophoresis (DGGE) was carried out for mutational analysis and DNA sequencing was performed in case of a suspected mutation.
  • RESULTS: Fourteen pleomorphic adenomas and 11 carcinomas ex pleomorphic adenoma were screened for p53 status and potent mutations.
  • CONCLUSION: We could not detect mutations of p53 neither in benign nor malignant parotid tumors and we therefore assume that p53 plays no role in the transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Genes, p53 / genetics. Parotid Neoplasms / genetics

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  • (PMID = 19950209.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Karakus MF, Ozcan KM, Dere H: Endoscopic resection of pleomorphic adenoma of the nasal septum. Tumori; 2007 May-Jun;93(3):300-1
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  • [Title] Endoscopic resection of pleomorphic adenoma of the nasal septum.
  • Pleomorphic adenomas originating from the minor salivary glands are rare in the nasal cavity.
  • Total surgical excision is the preferred treatment for pleomorphic adenomas.
  • Endoscopic tumor removal produces less morbidity, reduces blood loss during surgery, decreases hospital stay, avoids external scars and excessive unnecessary resection, enables the surgeon to better visualize the tumor margins, and has a low recurrence rate.
  • However, only 3 pleomorphic adenomas of the nasal septum have been removed by the endoscopic approach to date.
  • In this paper we report on a case of pleomorphic adenoma of the nasal septum that was removed successfully by the endoscopic approach without any recurrences.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Endoscopy. Nasal Septum / surgery. Nose Neoplasms / surgery

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  • (PMID = 17679469.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 11
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59. Orzechowska-Wylegała B, Jedrzejewski P, Wylegała E, Steplewska K: Recurrent benign pleomorphic adenoma of the lacrimal gland--a case report. Klin Oczna; 2008;110(7-9):301-3

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  • [Title] Recurrent benign pleomorphic adenoma of the lacrimal gland--a case report.
  • Benign pleomorphic adenoma (mixed tumor) is the most frequently occurring tumor of epithelial origin.
  • It occurs in serous glands, most frequently in parotid glands and rarely in small palatine glands, cheek glands, palatine tonsils and the lacrimal gland.
  • This study is a description of the therapeutic management of a patient with recurrent pleomorphic adenoma of the lacrimal gland.
  • In 1996, a 35 year old male patient underwent surgery to remove a tumor of the left orbit.
  • Histopathological examination revealed pleomorphic adenoma.
  • In 2005, from a cut along the upper-outer edge of the left orbit, an elastic and soft tumor 1 cm in diameter was removed from soft tissues of the upper eyelid.
  • An eyelid nodule of 0.8 mm in diameter was removed together with an elastic and hard tumor of size 2.5 x 1 cm.
  • The result of the histopathological examination of the palpebral tumor was pseudocystic tumor and of the orbital tumor was pleomorphic adenoma.
  • CONCLUSION: patients resected for pleomorphic adenoma of the lacrimal gland require a long period of postoperative observation and periodic ophthalmologic examination.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Lacrimal Apparatus / pathology. Orbital Neoplasms / pathology. Orbital Neoplasms / surgery

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  • (PMID = 19112866.001).
  • [ISSN] 0023-2157
  • [Journal-full-title] Klinika oczna
  • [ISO-abbreviation] Klin Oczna
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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60. Tarakji B, Nassani MZ: Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types). Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e697-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of p21 in normal tissues of salivary gland, pleomorphic adenoma and carcinoma ex pleomorphic adenoma-(undifferentiated and adenocarcinoma types).
  • OBJECTIVE: Our study aimed to characterize alteration in the immunohistochemical expression of p21 in normal tissue of the salivary gland surrounding pleomorphic adenoma, the tumor cells of pleomorphic adenomas, and carcinoma arising in pleomorphic adenoma.
  • STUDY DESIGN: A selected series of 29 cases of pleomorphic adenomas, and 27 cases of carcinoma ex-pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined.
  • RESULTS: The results showed that p21 expression was negative in the most components of normal tissue of the salivary gland surrounding pleomorphic adenoma, 24 cases out of 29 of the non tumour duct cells (82.8%), and 28 (96.6%) cases out of 29 of the acinar cells shows negative p21 expression.
  • P21 expression in pleomorphic adenomas shows that 2 cases out of 29 (6.9%) strongly expressed in the duct cells. p21 was strongly expressed in carcinoma cells in 9 (33.3%) cases out of 27.
  • CONCLUSION: Our data suggest that the strong nuclear staining as an indicator for altered p21, then the alteration of p21 expression would increase from pleomorphic adenoma to carcinoma arising in pleomorphic adenomas (6.9% versus 33.3%).
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / biosynthesis. Salivary Gland Neoplasms / metabolism. Salivary Glands / metabolism

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  • (PMID = 20383106.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p21
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61. Tarakji B, Nassani MZ: Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons. Kulak Burun Bogaz Ihtis Derg; 2010 May-Jun;20(3):129-36
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  • [Title] Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons.
  • OBJECTIVES: This study aims to highlight the current points of view regarding the management of pleomorphic adenomas among oral and maxillofacial surgeons in the United Kingdom.
  • The survey evaluated the surgical experience of the surgeon, the preferred surgical treatment of a newly diagnosed 3 cm diameter pleomorphic adenoma in the superficial lobe of the parotid gland in an adult and a child, and the treatment options of pleomorphic salivary adenoma (PSA) with the four following scenarios: (i) PSA with complete excision or incomplete excision;.
  • (ii) PSA with carcinoma in situ (atypical pleomorphic adenoma) with complete excision or incomplete excision;.
  • The results showed that there was no significant difference in the opinions of the respondents regarding treatment of pleomorphic adenoma in both adults and children.
  • There was a consensus on complete excision for the treatment of carcinoma in situ (atypical pleomorphic adenoma) or PSA with non-invasive malignant transformation.
  • CONCLUSION: This survey shows that superficial parotidectomy is the standard treatment method for primary pleomorphic adenoma in children and adults.
  • Surgery combined with radiotherapy is the preferred option in the case of multinodular recurrence, and surgery alone is recommended in the case of a solitary recurrence.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Health Care Surveys. Parotid Neoplasms / surgery
  • [MeSH-minor] Adult. Child. Combined Modality Therapy. Data Collection. Great Britain. Humans. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Otolaryngology. Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery. Societies, Medical. Surgical Procedures, Operative / methods

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  • (PMID = 20465538.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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62. Ascani G, Messi M, Balercia P: [Surgical management of pleomorphic adenoma of the salivary glands: our experience]. G Chir; 2008 Aug-Sep;29(8-9):343-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical management of pleomorphic adenoma of the salivary glands: our experience].
  • [Transliterated title] Trattamento dell'adenoma pleomorfo delle ghiandole salivari: nostra esperienza.
  • BACKGROUND: Pleomorphic adenoma is a benign epithelial tumour of adenoid structure preferentially arising from the parotid gland.
  • AIM: To analyse the outcome of patients with pleomorphic adenoma from salivary glands in order to evaluate the surgical strategy.
  • PATIENTS AND METHODS: This is an audit of a 15-year period where 347 pleomorphic adenomas of the salivary glands were treated by the authors.
  • RESULTS: The pleomorphic adenoma preferentially originated in the parotid gland (89.1%), and rarely in other glands.
  • The tumour occurred more often in females than in males (F:M=1.5).
  • CONCLUSION: The epidemiological aspects of pleomorphic adenoma of salivary glands retrieved in our study are similar to those reported in literature; moreover this study demonstrates that pericapsular enucleation is a viable alternative to superficial parotidectomy for the majority of parotid localizations, associated with reduced morbidity without oncological compromise.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery

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  • (PMID = 18834565.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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63. Dubb M, Michelow P: Cytologic features of chondroid syringoma in fine needle aspiration biopsies: a report of 3 cases. Acta Cytol; 2010 Mar-Apr;54(2):183-6
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  • [Title] Cytologic features of chondroid syringoma in fine needle aspiration biopsies: a report of 3 cases.
  • However, most clinicians prefer to diagnose suspected skin tumors by excisional biopsy as they are easily accessible, with the result that benign skin adnexal tumors are rarely encountered on FNA, often leading to misdiagnosis and mismanagement of patients.
  • We describe the cytologic features of chondroid syringoma in 3 cases in order to facilitate cytologic diagnosis of this lesion.
  • CASES: Three patients each presented with a mass lesion in the head and neck region and on FNA were diagnosed as having chondroid syringomas.
  • CONCLUSION: Knowledge of the cytologic features of chondroid syringoma will allow definitive diagnosis and correct management of the patient.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 20391975.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Marcos Ordóñez M, García Lagarto E, Santos Pérez J, Moráis Pérez D: [Carcinoma on pleomorphic adenoma in cervical salivary heteropia. Handling of one case and literature review]. Acta Otorrinolaringol Esp; 2007 Oct;58(8):371-4
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  • [Title] [Carcinoma on pleomorphic adenoma in cervical salivary heteropia. Handling of one case and literature review].
  • [Transliterated title] Carcinoma sobre adenoma pleomorfo en heterotopia salival cervical. Manejo de un caso y revisión de la literatura.
  • The presence of salivary tissue outside of the salivary glands, a term called "salivary heterotopia," is not very common.
  • The co-existence of carcinoma expleomorphic adenoma in a salivary heterotopia in the upper third of the neck can be considered unusual.
  • We present an infrequent and clinically unsuspected case of carcinoma expleomorphic adenoma in the upper third of the neck and independent of the salivary glands.
  • The tumour developed within heterotopic salivary tissue, with the histopathological study of the surgical extract being decisive for its diagnosis.
  • The cervical salivary embryogenesis of heterotopias and their oncogenesis is analyzed.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Adenoma, Pleomorphic / pathology. Carcinoma / complications. Carcinoma / pathology. Choristoma / complications. Choristoma / pathology. Salivary Gland Neoplasms / complications. Salivary Gland Neoplasms / pathology

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  • (PMID = 17949666.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 12
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65. Nitassi S, Oujilal M, Boulaich M, Essakalli L, Kzadri M: [Giant pleomorphic adenoma of the parotid gland]. Rev Stomatol Chir Maxillofac; 2009 Dec;110(6):350-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant pleomorphic adenoma of the parotid gland].
  • [Transliterated title] Adénome pléomorphe géant de la parotide.
  • INTRODUCTION: Slow evolution pleomorphic parotid adenoma may be diagnosed late.
  • These giant tumors have a functional, esthetic, and social impact.
  • We present a case of a giant pleomorphic adenoma involving the parotid glands and try to explain the reasons for the diagnostic delay and describe therapeutic specificities.
  • The CT scan revealed a heterogeneous tumor with hyperdense and hypodense areas without any associate lesions.
  • A total conservative parotidectomy was performed; the anatomopathological examination confirmed the diagnosis of a pleomorphic adenoma, weighing 1.2kg for a diameter of 19cm, without malignant degeneration.
  • DISCUSSION: The recommended treatment for giant parotid adenoma is total conservative parotidectomy.
  • Besides its functional and esthetic impact, the giant parotid adenoma is at high risk of malignant degeneration.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 19833364.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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66. Brunese L, Ciccarelli R, Fucili S, Romeo A, Napolitano G, D'Auria V, Collina A, Califano L, Cappabianca S, Sodano A: Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography. Dentomaxillofac Radiol; 2008 Dec;37(8):464-9
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  • [Title] Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography.
  • OBJECTIVES: To assess the efficacy of multiphasic CT with 8 min delayed acquisition in the differential diagnosis between pleomorphic adenomas and other parotid neoplasias.
  • RESULTS: On histological examination, 36 tumours were classified as pleomorphic adenomas and 26 as non-pleomorphic adenomas.
  • On the basis of a statistical comparison, the third phase proved to be the most effective in the differential diagnosis between pleomorphic adenoma and non-pleomorphic adenomas, both for the assessment of the degree of the enhancement (in this phase, strong enhancement showed a sensitivity of 61.11%, specificity of 100%, positive predictive value (PPV) of 100% and negative predictive value (NPV) of 53.33%) and, above all, for the homogeneity of the enhancement (in this phase, indeed, uniform enhancement showed sensitivity, specificity, PPV and NPV of 100%).
  • CONCLUSIONS: Our results seem to indicate that multiphasic CT with 8 min delayed acquisition allows the differential diagnosis between pleomorphic adenomas and other parotid neoplasias.
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Parotid Neoplasms / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19033432.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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67. Shimoyama Y, Yamashita K, Ohmachi T, Akihara Y, Sako T, Hirayama K, Okamoto M, Taniyama H: Pleomorphic adenoma of the salivary gland in two dogs. J Comp Pathol; 2006 Feb-Apr;134(2-3):254-9
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  • [Title] Pleomorphic adenoma of the salivary gland in two dogs.
  • Pleomorphic adenomas of the salivary gland were diagnosed in two dogs.
  • Labelling for GFAP indicated stromal transformation into myxoid and chondroid tissues.
  • [MeSH-major] Adenoma, Pleomorphic / veterinary. Dog Diseases / pathology. Parotid Neoplasms / veterinary. Sublingual Gland Neoplasms / veterinary
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Disease-Free Survival. Dogs. Immunoenzyme Techniques / veterinary. Male. Salivary Glands / pathology. Salivary Glands / surgery

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  • (PMID = 16542673.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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68. Molina EJ, Mayer K, Khurana J, Grewal H: Pleomorphic adenoma of the submandibular gland. J Pediatr Surg; 2008 Jun;43(6):1224-6
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  • [Title] Pleomorphic adenoma of the submandibular gland.
  • Pleomorphic adenomas of the submandibular glands are exceedingly rare tumors in the pediatric practice.
  • Radiologic studies are usually unable to differentiate benign from malignant tumors in most cases.
  • Recurrences are rare with complete en bloc excision of the tumor and the submandibular gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 18558215.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Zheng YG, Zhao Y, Wu LY: [Metastasizing pleomorphic adenoma of the submandibular gland: a case report]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2007 Jun;25(3):307-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastasizing pleomorphic adenoma of the submandibular gland: a case report].
  • Metastasizing pleomorphic adenomas without histological evidence of malignancy have rarely been reported.
  • A case of 30-year-old woman with a mass which showed a benign pleomorphic adenoma appearanced histologically in the left submandibular gland and right supercollarbone respectively was described.
  • Eight years ago, the patient suffered from pleomorphic adenoma of the left submandibular gland.
  • It revealed histopathologic features consistent with the recurrent and metastasizing tumor.
  • The clinic pathological features, possible mechanism and prevention approach of metastasizing pleomorphic adenoma were discussed based on previously reports in the literature.
  • [MeSH-major] Parotid Neoplasms. Submandibular Gland
  • [MeSH-minor] Adenoma, Pleomorphic. Female. Humans. Salivary Gland Neoplasms

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  • (PMID = 17629216.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Salivary Gland Adenoma, Pleomorphic
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70. Gao P, Zhou GY, Song XR, Hou JX, Zhang CJ, Ma C: [The relationship of abnormal expression of cell glucoprotein with recurrence of pleomorphic adenoma in salivary gland]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2005 Apr;23(2):164-6
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  • [Title] [The relationship of abnormal expression of cell glucoprotein with recurrence of pleomorphic adenoma in salivary gland].
  • OBJECTIVE: To study the relationship of expression of mucin 1 and E-cadherin with recurrence of pleomorphic adenoma in salivary gland, and to investigate the signal to predict the recurrence potential of the tumor.
  • METHODS: ; The capsule of tumor was observed by microscope.
  • The expression of mucin 1 and E-cadherin in 33 cases of primary adenoma, 12 cases of recurrent pleomorphic adenomas and 7 cases of malignant pleomorphic adenomas were detected by immunohistochemistry.
  • RESULTS: There was no significant difference about the status of capsule and the positive rate of mucin 1 expression between primary and recurrent pleomorphic adenoma (P > 0.05).
  • The abnormal distribution of mucin 1 expression was observed in recurrent pleomorphic adenoma (6/8), which was characterized by the positive staining of the whole cytomembrane.
  • On the other hand, positive staining of the primary pleomorphic adenoma was observed on the top of the membrane (19/21).
  • The staining pattern in malignant pleomorphic adenoma was similar with the recurrent ones except higher ratio of positive expression.
  • No significant different was observed among the three kind of tumors on the expression rate of E-cadherin (P > 0.05).
  • CONCLUSION: The status of capsule didn't have much actual usage in predicting the recurrence of pleomorphic adenoma.
  • There was no significant relationship between the expression of E-cd and the recurrence of the tumor.
  • The abnormal distribution of mucin 1 expression contributes to the invasiveness of the tumor and can be used as the predictive signal for recurrence of pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / physiopathology. Cadherins / metabolism. Mucin-1 / metabolism. Salivary Gland Neoplasms / physiopathology

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  • (PMID = 15952635.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cadherins; 0 / Mucin-1
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71. Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, Soares J: PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. Mod Pathol; 2005 Aug;18(8):1048-55
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  • [Title] PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry.
  • Pleomorphic adenoma is the most common benign tumor of the salivary glands.
  • It has marked histological diversity with epithelial, myoepithelial and mesenchymal-type cells arranged in a variety of architectural and differentiation patterns.
  • Pleomorphic adenoma gene 1 (PLAG1), shown to be consistently rearranged in pleomorphic adenomas, is activated by chromosomal translocations involving 8q12, the chromosome region that is most frequently affected in these tumors.
  • In this study, we evaluated PLAG1 involvement in salivary gland tumorigenesis by determining the frequency of its alterations in a selected group of 20 salivary gland tumors: 16 pleomorphic adenomas and four carcinomas ex-pleomorphic adenoma, having in common the presence of karyotypic chromosome 8 deviations, either structural, with 8q12 rearrangements, or numerical, with gain of chromosome 8.
  • Except for one pleomorphic adenoma case (5%) that lacked PLAG1 involvement, 17 tumors (85%), (14 pleomorphic adenomas and three carcinomas ex-pleomorphic adenoma) showed intragenic rearrangements of PLAG1 and the remaining two cases (10%), (one pleomorphic adenoma and one carcinoma ex-pleomorphic adenoma), had chromosome trisomy 8 only.
  • To further investigate the role of PLAG1 on pleomorphic adenomas tumorigenesis, as well as the putative morphogenesis mechanism, we attempted to identify the cell types (epithelial vs myoepithelial) carrying 8q12/PLAG1 abnormalities by a combined phenotypic/genotypic analysis in four cases (three pleomorphic adenoma and one carcinoma ex-pleomorphic adenoma) characterized by 8q12 translocations and PLAG1 rearrangement.
  • This finding further supports the pluripotent single-cell theory, which postulates that the tumor-initiated, modified myoepithelial cell, evolves into the varied somatic cell phenotypes present in pleomorphic adenoma, and reinforces the role of PLAG1 on the tumorigenesis of benign and malignant pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. DNA-Binding Proteins / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 15920557.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human
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72. Malinvaud D, Couloigner V, Badoual C, Halimi P, Bonfils P: Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus. Auris Nasus Larynx; 2006 Dec;33(4):417-21
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  • [Title] Pleomorphic adenoma of the nasal septum and its relationship with Epstein-Barr virus.
  • OBJECTIVES: Pleomorphic adenoma is the most common benign tumor of the major salivary glands, especially of the parotid gland.
  • It is much less common in the minor salivary glands of the oral cavity, and it rarely occurs in others sites in the head and neck.
  • Even if virus involvement in salivary glands tumor has been many times discuted, the etiology of this tumor keeps being unknown.
  • As compared to other nasal tumors, we tried to prove if Epstein-Barr virus (EBV) could be involved in the development of pleomorphic adenoma in this particular nasal localization.
  • METHODS: Three cases of pleomorphic adenomas of the nasal septum (two women and a man in age of 23-59 years) were retrospectively studied.
  • All the patients had undergone endoscopic surgery to remove the complete tumor.
  • We used hybridation technique in the search for EBV-DNA in the three tumors.
  • RESULTS AND CONCLUSION: We had positive EBV-DNA detection in the tumor in one case, which seemed to prove relationship between pleomorphic adenoma and this virus.
  • The literature concerning the subject is reviewed in order to explain EBV involvement in the development of such tumors in this particular localization.
  • [MeSH-major] Adenoma, Pleomorphic / virology. DNA, Viral / analysis. Herpesvirus 4, Human / isolation & purification. Nasal Septum / surgery. Salivary Gland Neoplasms / virology

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  • (PMID = 16895748.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / DNA, Viral
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73. Parwani AV, Lujan G, Ali SZ: Myoepithelial carcinoma arising in a pleomorphic adenoma of the parotid gland: report of a case with cytopathologic findings. Acta Cytol; 2006 Jan-Feb;50(1):93-6
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  • [Title] Myoepithelial carcinoma arising in a pleomorphic adenoma of the parotid gland: report of a case with cytopathologic findings.
  • BACKGROUND: Carcinoma arising in a mixed tumor, or carcinoma ex pleomorphic adenoma (CEPA), is an uncommon primary salivary gland neoplasm.
  • Computed tomography-guide fine needle aspiration (FNA) showed a biphasic neoplasm with epithelial and stromal components consistent with pleomorphic adenoma (PA).
  • However, in addition, a distinct population of discohesive atypical and pleomorphic cells with high nuclear/cytoplasmic ratio was noted in the background.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Carcinoma / diagnosis. Myoepithelioma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 16514848.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Bonet-Loscertales M, Armengot-Carceller M, Gaona-Morales J, Basterra-Alegría J: Multicentric recurrent parotid pleomorphic adenoma in a child. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e743-5

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  • [Title] Multicentric recurrent parotid pleomorphic adenoma in a child.
  • Mixed tumours of the parotid gland are rare in childhood and recurrence of this tumour is infrequent.
  • Also the first surgical treatment, tumour enucleation or parotidectomy, has been implicated as a cause for recurrence.
  • We present a case of a multicentric doubly recurrent parotid pleomorphic adenoma, 7 and 14 years after tumour enucleation, in a 9-year-old child.
  • All the nodules resected showed the hypocellular variant of pleomorphic adenoma.
  • We consider the relationships between the choice of treatment, the histologic subtypes of pleomorphic adenomas and multifocal tumours and recurrence.
  • We conclude that tumour enucleation is a risk factor for recurrence and total parotidectomy is the treatment of choice for pleomorphic parotid adenoma also in childhood.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20173712.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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75. Qureshi A: True malignant mixed tumor of parotid. J Coll Physicians Surg Pak; 2007 Nov;17(11):697-8

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  • [Title] True malignant mixed tumor of parotid.
  • Carcinosarcoma is a rare malignant neoplasm of salivary glands that manifests both carcinomatous and sarcomatous components.
  • Specimen of a recurrent parotid tumor of a 55-year-old male was received for histopathology.
  • Diagnosis of a biphasic malignant neoplasm was made.
  • Morphology and immunohistochemical profile were consistent with carcinosarcoma i.e. true malignant mixed tumor.

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  • (PMID = 18070582.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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76. Takahira M, Nakamura Y, Shimizu S, Minato H, Katori N, Kobayashi H, Nakatani Y, Sugiyama K: Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. Am J Ophthalmol; 2005 Aug;140(2):337-40
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  • [Title] Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma.
  • PURPOSE: To report a case of the lacrimal gland tumor diagnosed as carcinosarcoma (true mixed tumor) arising from a pleomorphic adenoma.
  • METHODS: An 80-year-old Japanese woman was referred with a well-circumscribed tumor in the lacrimal fossa.
  • RESULTS: The tumor was excised, but the deepest portion remained because of heavy bleeding.
  • Histopathologically, the tumor consisted of osteosarcomatous cells.
  • Two months later, the tumor progressed further and was excised completely with lateral orbitotomy.
  • The tumor consisted primarily of osteosarcomatous component but also had epithelial components including carcinoma and pleomorphic adenoma.
  • CONCLUSION: The tumor was diagnosed as true carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma.
  • When lacrimal gland tumors containing sarcomatous components are encountered, carcinosarcoma should be included in the differential diagnosis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinosarcoma / pathology. Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Magnetic Resonance Imaging

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  • (PMID = 16086968.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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77. Stodulski D, Rzepko R, Kowalska B, Stankiewicz C: [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review]. Otolaryngol Pol; 2007;61(5):687-93
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  • [Title] [Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review].
  • BACKGROUND: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands.
  • There are three subtypes of malignant PA: carcinoma ex pleomorphic adenoma (CXPA); carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma.
  • For proper diagnosis of CXPA, a statement of coexistence of pleomorphic adenoma and carcinoma (or carcinoma after prior PA surgery) is needed.
  • The following clinical factors were evaluated: age, sex, symptoms (time of lasting, evolution), tumor size, invasion of the adjacent structures and facial nerve, neck nodes, clinical stage, treatment outcome.
  • One pathologist reviewed histological material of 18 out of 19 patients who had been operated and pathological factors such as sensitivity and accuracy of fine needle aspiration biopsy, grade, histology and proportion of malignant component in tumor, lymph nodes metastases were analyzed.
  • In 15 cases, tumor was localized in the parotid and in 4 in the submandibular gland.
  • Duration of symptoms of benign PA was from 2 to 40 years (mean 17.8 years).
  • Symptoms of malignant transformation occurred in 15 patients, the most common were rapid enlargement of tumor, pain and facial nerve palsy.
  • Tumor size varied from 2 to 20 cm with a mean of 6 cm.
  • 17 out of 18 tumors reviewed by the pathologist were high grade.
  • The best method of prevention and treatment of CXPA is early and radical removal of all major salivary glands tumors.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • (PMID = 18552001.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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78. El Kohen A, Essakalli L, Kzadri M, Sefiani S, Seffar Andaloussi Z: [Pleomorphic adenoma of the tongue base]. Rev Stomatol Chir Maxillofac; 2007 Jun;108(3):215-7
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  • [Title] [Pleomorphic adenoma of the tongue base].
  • [Transliterated title] Adénome pléomorphe de la base de langue.
  • INTRODUCTION: Pleomorphic adenoma is the most common lesion of minor salivary glands but is exceptional in the tongue base.
  • REPORT CASE: We report the case of a 70-year-old woman with pleomorphic adenoma of the tongue base.
  • Physical examination and computed tomography revealed a cystic tumour located in the right side of tongue base.
  • The tumor was removed by transoral resection.
  • The histological examination demonstrated a pleomorphic adenoma.
  • DISCUSSION: We will discuss the diagnostic and therapeutically modalities of pleomorphic adenoma of the tongue base with a review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 17459439.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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79. Wielgosz R, Schwarz C, Mroczkowski E: [Pleomorphic adenoma of the palate. Case report]. Otolaryngol Pol; 2006;60(3):429-31

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  • [Title] [Pleomorphic adenoma of the palate. Case report].
  • [Transliterated title] Gruczolak wielopostaciowy podniebienia. Opis przypadku.
  • Report on a huge pleomorphic adenoma (diameter 6 cm) of the right palate extending into the posterior part of the oral cavity.
  • The dimension of the tumour and anatomical relations were documented with the use of nuclear magnetic resonance.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Palatal Neoplasms / diagnosis. Palatal Neoplasms / surgery
  • [MeSH-minor] Adult. Humans. Male. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / surgery. Treatment Outcome

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  • (PMID = 16989460.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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80. Stomeo F, Rocca PC, Bozzo C, Bianchini C, Meloni F, Pastore A: Laryngeal true malignant mixed tumor. Head Neck; 2009 Apr;31(4):556-60

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  • [Title] Laryngeal true malignant mixed tumor.
  • BACKGROUND: True malignant mixed tumor, also known as carcinosarcoma, is a salivary gland type malignant neoplasm, which is extremely rare, and only a few cases arising in the larynx have been previously reported.
  • METHODS AND RESULTS: We report a case of true malignant mixed tumor arising in the larynx of a 65-year-old woman successfully treated with surgery.
  • Histologically, the neoplasm was composed of variably mixed, neoplastic glandular, spindle, and chondroid tissues.
  • CONCLUSION: These results strengthen the hypothesis that these neoplasms may develop from a divergent differentiation of a totipotent, myoepithelial precursor cell.
  • [MeSH-major] Carcinosarcoma / pathology. Laryngeal Neoplasms / pathology. Mixed Tumor, Malignant / pathology

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  • (PMID = 18972426.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Lee BH: Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space. Jpn J Radiol; 2010 Apr;28(3):224-6

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  • [Title] Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space.
  • Unilateral agenesis of the parotid gland is a rare condition.
  • Although pleomorphic adenomas are the most common benign glandular tumors of the buccal space, to the author's knowledge unilateral agenesis of the parotid gland associated with pleomorphic adenoma in the ipsilatearal buccal space has not been previously described in the literature.
  • [MeSH-major] Adenoma, Pleomorphic / diagnostic imaging. Cheek. Parotid Gland / abnormalities
  • [MeSH-minor] Aged. Female. Humans. Salivary Gland Neoplasms / diagnostic imaging. Salivary Glands, Minor. Tomography, X-Ray Computed

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  • (PMID = 20437134.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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82. Matsubayashi S, Yoshihara T: Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study. Eur Arch Otorhinolaryngol; 2007 Jul;264(7):789-95
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  • [Title] Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study.
  • The proliferative activity of the tumor cells and the expression of tumor-associated genes and sex steroid hormone receptors were investigated immunohistochemically in ten cases of carcinoma ex pleomorphic adenoma (Ca-ex-PA) of the salivary glands.
  • These were analyzed in benign and malignant components separately, and then were compared with ten cases of the other malignant tumors [adenocarcinomas, not otherwise specified (ACN) and salivary duct carcinomas (SDC)] and ten cases of pleomorphic adenomas (PA).
  • (1) malignant component of Ca-ex-PA showed a higher incidence of PCNA and Ki67 than benign component of Ca-ex-PA.
  • A significant difference between benign component of Ca-ex-PA and PA was not observed. (2) A significant difference in the incidence of p53, c-erbB-2, EGFR overexpression was observed only between malignant component of Ca-ex-PA and benign component of Ca-ex-PA. (3) The incidence of PCNA, Ki67, p53, c-erbB-2 overexpression in malignant component of Ca-ex-PA showed the highest data among the four groups.
  • These results suggest that Ca-ex-PA acquired the particular biological behavior in contrast to the other salivary neoplasms in the long-standing process while PA undergoes malignant transformation.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Antibodies, Neoplasm / immunology. Biomarkers, Tumor / immunology. Carcinoma, Ductal / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry / methods. Ki-67 Antigen / immunology. Ki-67 Antigen / metabolism. Male. Middle Aged. Neoplasm Recurrence, Local / immunology. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Proliferating Cell Nuclear Antigen / immunology. Proliferating Cell Nuclear Antigen / metabolism. Receptor, Epidermal Growth Factor / immunology. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / immunology. Receptor, ErbB-2 / metabolism. Receptors, Androgen / immunology. Receptors, Androgen / metabolism. Receptors, Estrogen / immunology. Receptors, Estrogen / metabolism. Retrospective Studies. Tumor Suppressor Protein p53 / immunology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17310348.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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83. Zbären P, Stauffer E: Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors. Head Neck; 2007 Aug;29(8):751-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors.
  • BACKGROUND: Histopathologic features of the capsule may have an impact on the recurrence rate of pleomorphic adenomas.
  • METHODS: Retrospective (n = 154) and prospective (n = 64) histologic analysis of the capsular characteristics such as incompleteness, tumor penetration, pseudopodia, and satellite tumors of 218 pleomorphic adenomas.
  • RESULTS: In 160 of the 218 (73%) pleomorphic adenomas, 1 or more capsular characteristics such as incomplete capsule (33%), capsule penetration (26%), pseudopodia (40%), and satellite nodules (13%) were detected.
  • Incomplete capsule and satellite tumors were most frequently seen in the stroma-rich (myxoid) subtype.
  • CONCLUSION: Pseudopodia and satellite tumors were more common than reported in the literature.
  • If left in the surrounding salivary gland tissue at surgery, they can lead to recurrences of pleomorphic adenomas of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17252593.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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84. Biernat W: Lipomatous mixed tumor of the skin. Am J Dermatopathol; 2008 Jun;30(3):284-6
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  • [Title] Lipomatous mixed tumor of the skin.
  • An unusual tumor of the neck in a 56-year-old female is reported.
  • The tumor was composed of tubules and small cords of epithelial cells dispersed in the fibromyxoid and adipose stroma.
  • At the periphery, the tumor was not encapsulated and its border was intermingled with the subcutaneous fat.
  • Lack of decapitation secretion and the absence of long tubules suggested an eccrine origin; however, in some of the tumor areas, the cells showed brightly eosinophilic copious cytoplasm that may indicate an apocrine differentiation.
  • As an area of chondroid metaplasia was identified, the diagnosis of a mixed tumor was rendered.
  • This unusual type of skin adnexal neoplasm with unique relation of the epithelial component to the surrounding adipose tissue requires differentiation with the primary cutaneous and metastatic carcinomas.
  • [MeSH-major] Adipose Tissue / pathology. Head and Neck Neoplasms / diagnosis. Lipoma / pathology. Neoplasms, Complex and Mixed / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged. Neoplasm Metastasis / diagnosis

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  • (PMID = 18496435.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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85. Gibson A, Mavrikakis I, Rootman J, Dolman P: Lacrimal gland pleomorphic adenomas with low-density zones resembling cystic change on computed tomography. Ophthal Plast Reconstr Surg; 2007 May-Jun;23(3):234-5
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  • [Title] Lacrimal gland pleomorphic adenomas with low-density zones resembling cystic change on computed tomography.
  • We report 2 cases of pleomorphic adenoma with unusual radiologic findings.
  • CT showed lacrimal gland masses dominated by low-density areas resembling cysts.
  • Pathology revealed the lesions to be pleomorphic adenomas with myxomatous and/or cartilaginous features.
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Cysts / radiography. Eye Neoplasms / radiography. Lacrimal Apparatus Diseases / radiography. Tomography, X-Ray Computed

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  • (PMID = 17519667.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Bento PM, Freitas Rde A, Pinto LP, de Souza LB: Tenascin and fibronectin in pleomorphic adenoma of the salivary gland. J Appl Oral Sci; 2006 Jun;14(3):198-202
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  • [Title] Tenascin and fibronectin in pleomorphic adenoma of the salivary gland.
  • OBJECTIVES: To analyze the expression and distribution pattern of extracellular matrix components in pleomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case.
  • METHODS AND RESULTS: The expression of tenascin (TN) and fibronectin (FN) was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies.
  • Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma.
  • Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma.
  • CONCLUSIONS: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.

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  • (PMID = 19089073.001).
  • [ISSN] 1678-7765
  • [Journal-full-title] Journal of applied oral science : revista FOB
  • [ISO-abbreviation] J Appl Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC4327197
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87. Köybaşı S, Süslü AE, Tezcan E, Atasoy HI, Biçer YÖ, Boran Ç: Submandibular gland pleomorphic adenoma in a seven-year-old child: a case report. Kulak Burun Bogaz Ihtis Derg; 2010 Jul-Aug;20(4):210-3
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  • [Title] Submandibular gland pleomorphic adenoma in a seven-year-old child: a case report.
  • Salivary gland neoplasms are rare in the pediatric age group.
  • Pleomorphic adenomas in the submandibular gland are rarer.
  • The firm, mobile and painless mass was about 2x3 cm in size and with bimanual palpation it was indiscriminated from the submandibular gland.
  • Magnetic resonance imaging with contrast revealed a heterogeneous and minimally lobulated mass within the submandibular gland with clearly defined borders.
  • Fine needle aspiration biopsy revealed a diagnosis of pleomorphic adenoma and we performed right submandibular gland excision under general anesthesia.
  • The histopathological diagnosis was pleomorphic adenoma with sparse mitotic figures that may be interpreted as having a potential of malignant transformation.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Submandibular Gland Neoplasms / surgery
  • [MeSH-minor] Child. Female. Humans. Magnetic Resonance Imaging. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery. Salivary Glands / pathology. Treatment Outcome

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  • (PMID = 20626331.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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88. Kakimoto N, Gamoh S, Tamaki J, Kishino M, Murakami S, Furukawa S: CT and MR images of pleomorphic adenoma in major and minor salivary glands. Eur J Radiol; 2009 Mar;69(3):464-72
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  • [Title] CT and MR images of pleomorphic adenoma in major and minor salivary glands.
  • PURPOSE: To investigate the CT and MR imaging features of pleomorphic adenoma in the head and neck area.
  • MATERIALS AND METHODS: Our materials of this study consisted of 50 pleomorphic adenomas from 50 patients which were all histopathologically diagnosed.
  • The following features were evaluated: the detectability of the lesion, the tumor margin, the border of the lesion, the aspect of the lesion, the contrast between the lesion and surrounding tissue, the signal intensity of the lesion, the enhancement of contrast medium, the aspect of the lesion after the injection of contrast medium, the detectability of the capsule, and the detectability of bone resorption of the lesion.
  • RESULTS: The tumor detectabilities were 77% on axial plain CT images and 90% on axial CE CT images, respectively.
  • On CT images, pleomorphic adenoma tended to show a well-defined margin, a smooth border, an inhomogeneous aspect, a low or high contrast, and intermediate or high signal intensity.
  • After contrast medium administration, pleomorphic adenoma tended to show a slightly high enhancement and either an inhomogeneous or a periphery enhancement on the CE CT images.
  • The tumor detectabilities were 86% on axial T1-weighted MR images, 88% on axial T2-weighted MR images, and 85% on axial CE T1-weighted MR images, respectively.
  • On MR images, pleomorphic adenomas tended to show well-defined margin, a lobulate border, an inhomogeneous aspect, a high contrast, and intermediate or high signal intensity.
  • After contrast medium administration, pleomorphic adenoma tended to show a high enhancement and either an inhomogeneous or a periphery enhancement on MR images.
  • CONCLUSIONS: It was possible to detect the capsule in pleomorphic adenoma using MR images.
  • The pleomorphic adenomas in head and neck area should be evaluated with MR images.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Magnetic Resonance Imaging / methods. Salivary Gland Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 18093776.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Ireland
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89. Cho NP, Han HS, Soh Y, Son HJ: Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. J Oral Pathol Med; 2007 May;36(5):297-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma.
  • Although COX-2 expression has been shown to be up-regulated in carcinomas of the salivary gland, its mechanisms are not completely understood.
  • METHODS: The expression of COX-2 and HuR was determined by immunohistochemistry in 28 cases of salivary pleomorphic adenoma and 18 cases of salivary mucoepidermoid carcinoma.
  • RESULTS: 28.6% and 72.2% of the pleomorphic adenomas and mucoepidermoid carcinomas showed high COX-2 expression respectively.
  • 35.7% of pleomorphic adenomas and 72.2% of mucoepidermoid carcinomas were tested positive for HuR in the cytoplasm of tumor cells.
  • There was a correlation between a high COX-2 immunoreactivity and cytoplasmic HuR expression in mucoepidermoid carcinomas but not in pleomorphic adenomas.
  • CONCLUSION: This study suggests that cytoplasmic HuR is correlated with COX-2 expression in salivary mucoepidermoid carcinomas.
  • In addition, the immunoreactivity of COX-2 and cytoplasmic HuR might be used to evaluate the nature of a borderline malignancy in the salivary glands.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Antigens, Surface / metabolism. Carcinoma, Mucoepidermoid / metabolism. Cyclooxygenase 2 / metabolism. Neoplasm Proteins / metabolism. RNA-Binding Proteins / metabolism. Salivary Gland Neoplasms / metabolism

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  • (PMID = 17448140.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Surface; 0 / ELAV Proteins; 0 / ELAV-Like Protein 1; 0 / ELAVL1 protein, human; 0 / Neoplasm Proteins; 0 / RNA-Binding Proteins; EC 1.14.99.1 / Cyclooxygenase 2
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90. Emodi O, El-Naaj IA, Gordin A, Akrish S, Peled M: Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma). J Oral Maxillofac Surg; 2010 Sep;68(9):2092-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma).
  • PURPOSE: Of all benign salivary gland tumors of the parotid gland, pleomorphic adenoma (mixed tumor) is the most common.
  • It accounts for 60% to 70% of all benign tumors of the parotid gland.
  • PATIENTS AND METHODS: We reviewed 48 patients who underwent excision of pleomorphic adenoma of the parotid gland between 1996 and 2005 at Rambam Medical Center: 18 were treated surgically with the classical superficial parotidectomy (SP) technique, using an anterograde approach, and 30 were treated with retrograde partial superficial parotidectomy (PSP).
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Oral Surgical Procedures / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20728030.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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91. Hong KH, Yang YS: Intraoral approach for the treatment of submandibular salivary gland mixed tumors. Oral Oncol; 2008 May;44(5):491-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoral approach for the treatment of submandibular salivary gland mixed tumors.
  • Pleomorphic adenoma represents a most common benign neoplasm of major salivary glands.
  • Most occurrences of this benign tumor in the submandibular gland have been treated surgically without difficulty via transcervical approach.
  • In this study, we introduced the intraoral approach for the removal of the submandibular mixed tumor.
  • In total, 12 cases of pleomorphic adenoma of the submandibular gland were treated via intraoral approach.
  • During surgery the tumor and submandibular gland are easily dissected from surrounding tissue and removed through intraoral incision.
  • All patients were followed up for the recurrence of the tumor from 20 months to 10 years.
  • One patient showed a tumor recurrence at the early stage of this approach.
  • We propose that the benign mixed tumor of the submandibular gland could be removed easily via intraoral route without an external scar or nerve injury.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Postoperative Complications / prevention & control. Submandibular Gland / surgery. Submandibular Gland Neoplasms / surgery

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  • (PMID = 17827052.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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92. Giddings CE, Bray D, Rimmer J, Williamson P: Pleomorphic adenoma and severe obstructive sleep apnoea. J Laryngol Otol; 2005 Mar;119(3):226-9

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  • [Title] Pleomorphic adenoma and severe obstructive sleep apnoea.
  • Although minor salivary gland pleomorphic adenomas have been described as a cause of airway compromise, pleomorphic adenomata arising from the deep lobe of the parotid, causing proven obstructive sleep apnoea, have not previously been documented.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Parotid Neoplasms / complications. Sleep Apnea, Obstructive / etiology

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  • (PMID = 15845199.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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93. Kasashima S, Hiroshi M, Toshinori M, Yoshio O: Lipomatous mixed tumor with follicular differentiation of the skin. J Cutan Pathol; 2006 May;33(5):389-94
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  • [Title] Lipomatous mixed tumor with follicular differentiation of the skin.
  • A very rare case of cutaneous mixed tumor with numerous adipose tissue and hair follicular structures in a 67-year-old Japanese male was reported.
  • A well-circumscribed tumor was in the subcutaneous tissue of the cheek and far from the parotid gland.
  • Histologically, the tumor consisted of an admixture of the adipose tissue, fibromyxoid tissue with spindle cells, and branching tubular structures.
  • Outer layers of ductal epithelial cells and single spindle cells were often in a transition, likely as typical mixed tumor.
  • No chondroid stroma was seen.
  • To our knowledge, this tumor is the first case of a lipomatous mixed tumor with hair follicular differentiation.
  • The case indicates an additional wide spectrum of histologic appearances of cutaneous mixed tumor.
  • [MeSH-major] Adipose Tissue / pathology. Hair Follicle / pathology. Mixed Tumor, Malignant / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Apocrine Glands / pathology. Biomarkers, Tumor / analysis. Hair Diseases / metabolism. Hair Diseases / pathology. Humans. Immunohistochemistry. Male

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  • (PMID = 16640549.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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94. Zhao X, Ren W, Yang W, Wang Y, Kong H, Wang L, Yan L, Xu G, Fei J, Fu J, Zhang C, Wang Z: Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. Int J Cancer; 2006 Feb 1;118(3):643-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice.
  • Pleomorphic adenoma gene 1 (PLAG1) was found frequently rearranged and activated in human salivary gland pleomorphic adenomas.
  • Ectopic overexpression of PLAG1 has been proposed to play a crucial role in tumorigenesis of salivary gland pleomorphic adenomas.
  • In this report, we show that the salivary gland tumors developed in PLAG1 transgenic mice share major histopathologic features with human pleomorphic adenomas.
  • It was found that beta-catenin, the key component of Wnt signaling pathway, was upregulated at transcriptional level in tumors developed in 3 independent transgenic mouse lines.
  • Immunohistochemical staining revealed that expression of beta-catenin as well as c-myc, downstream of beta-catenin in Wnt signaling pathway, was highly upregulated with overexpression of PLAG1 transgene in tumor and normal transgenic salivary gland tissues.
  • Our findings provide the first in vivo evidence for the oncogenic activity of PLAG1 in pleomorphic adenoma tumorigenesis, reveal a valued animal model for human salivary gland tumors and suggest that Wnt signaling pathway may also contribute to the development of pleomorphic adenomas in transgenic mice.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. DNA-Binding Proteins / physiology. Proto-Oncogene Proteins c-myc / metabolism. Salivary Gland Neoplasms / genetics. Signal Transduction. Wnt Proteins / metabolism. beta Catenin / metabolism

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16108035.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Myc protein, mouse; 0 / PLAG1 protein, human; 0 / Proto-Oncogene Proteins c-myc; 0 / Wnt Proteins; 0 / beta Catenin
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95. Das DK, Anim JT: Pleomorphic adenoma of salivary gland: to what extent does fine needle aspiration cytology reflect histopathological features? Cytopathology; 2005 Apr;16(2):65-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of salivary gland: to what extent does fine needle aspiration cytology reflect histopathological features?
  • OBJECTIVE: The histological diversity encountered in pleomorphic adenoma may cause diagnostic difficulty in fine needle aspiration (FNA) cytology due to limited and selective sampling.
  • The present study based on 25 histologically confirmed pleomorphic adenoma cases attempts to find out to what extent FNA cytology reflects the histopathological features.
  • METHODS: May-Grunwald-Giemsa and Papanicolaou stained smears, and haematoxylin and eosin stained paraffin sections of 25 pleomorphic adenomas of parotid and submandibular glands were reviewed.
  • The frequency of morphological features such as squamous metaplastic cells, cells with oncocytic change, acinus formation, mucus globules, papilla formation, giant cells, myxoid and chondroid matrix as well as specific nuclear features was compared between the two diagnostic methods, and the statistical significance was determined using Fisher's exact test of probability.
  • Chondroid matrix was the only parameter which was significantly more common in histology than in cytology (44.0% versus 4.0%, p = 0.019).
  • CONCLUSION: FNA cytology demonstrates well most of the histological features of pleomorphic adenoma of salivary gland and may be considered a useful tool in initial assessment of the tumour.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Male. Parotid Gland / pathology. Sample Size. Sensitivity and Specificity. Staining and Labeling / methods. Submandibular Gland / pathology

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  • (PMID = 15787647.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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96. Miliauskas JR, Hunt JL: Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review. Head Neck Pathol; 2008 Dec;2(4):339-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review.
  • Multiple separate tumors developing in a single salivary gland is rare in previously untreated patients.
  • Tumors that can be multicentric include Warthin tumor, oncocytoma, basal cell adenoma and acinic cell carcinoma.
  • The incidence of multiple primary unilateral pleomorphic adenomas is extremely rare in patients with no prior history of trauma or surgery.
  • We report two cases of primary multicentric pleomorphic adenoma and review the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Loss of Heterozygosity. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • [Cites] Laryngorhinootologie. 2007 Jun;86(6):448-50 [17219338.001]
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  • (PMID = 20614306.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2807582
  • [Keywords] NOTNLM ; Multifocal / Parotid gland / Pleomorphic adenoma
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97. Debnath SC, Saikia AK, Debnath A: Pleomorphic adenoma of the palate. J Maxillofac Oral Surg; 2010 Dec;9(4):420-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the palate.
  • Pleomorphic adenoma is a benign tumor of the salivary glands that has elements of both epithelial and mesenchymal tissues.
  • The tumor most commonly arises in the parotid or submandibular glands.
  • Infrequently, it may arise from the minor salivary glands and present as an intraoral mass over the palate or lip.

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  • (PMID = 22190837.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177488
  • [Keywords] NOTNLM ; Palate / Pleomorphic adenoma / Salivary gland
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98. Chang CJ, Lin TK, Wei LC, Wen MC, Tsai HY, Wang JC, Tai MC: Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. Ann Ophthalmol (Skokie); 2006;38(2):141-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report.
  • Carcinoma ex pleomorphic adenoma affects glandular structures, occurring mostly in major salivary glands and less commonly in the lacrimal gland.
  • We present a rare case in the lacrimal gland.
  • We highlight the importance of keeping this rare tumor in mind and the early detection of symptoms because such a malignant transformation could occur in pleomorphic adenomas, with the proportion dependent on the duration of the tumor.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Eye Neoplasms / diagnosis. Lacrimal Apparatus Diseases / diagnosis

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  • (PMID = 17416946.001).
  • [ISSN] 1558-9951
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Wagner M, Klussmann JP, Dirsch O, Rose VA, Guntinas-Lichius O, Theegarten D, Sudhoff H, Linder R: Low prevalence of transfusion transmitted virus (TTV)-like DNA sequences in cystadenolymphoma and pleomorphic adenoma of the salivary glands. Eur Arch Otorhinolaryngol; 2006 Aug;263(8):759-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low prevalence of transfusion transmitted virus (TTV)-like DNA sequences in cystadenolymphoma and pleomorphic adenoma of the salivary glands.
  • The present study was conducted to determine whether TTV-like DNA sequence elements play a role in the pathogenesis of cystadenolymphoma or pleomorphic adenoma and if the parotid or the submandibular gland is a major source of TTV persistence.
  • Sixty-two archival salivary gland samples (16 cystadenolymphomas, 13 pleomorphic adenomas, and 33 controls) and 23 corresponding saliva samples were examined using a polymerase chain reaction (PCR) for TTV DNA.
  • TTV appears to be only a bystander in cystadenolymphoma, pleomorphic adenoma, and other salivary gland affections.
  • [MeSH-major] Adenolymphoma / virology. Adenoma, Pleomorphic / virology. DNA, Viral / analysis. Salivary Gland Neoplasms / virology. Torque teno virus / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. Case-Control Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Molecular Sequence Data. Parotid Gland / pathology. Parotid Gland / virology. Polymerase Chain Reaction. Prevalence. Saliva / virology. Sequence Analysis, DNA. Submandibular Gland / pathology. Submandibular Gland / virology

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  • [ErratumIn] Eur Arch Otorhinolaryngol. 2006 Nov;263(11):1060
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  • (PMID = 16703387.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Viral
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100. Ito FA, Jorge J, Vargas PA, Lopes MA: Histopathological findings of pleomorphic adenomas of the salivary glands. Med Oral Patol Oral Cir Bucal; 2009 Feb;14(2):E57-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological findings of pleomorphic adenomas of the salivary glands.
  • OBJECTIVES: To describe the histopathological features of pleomorphic adenoma (PA) with special reference to the epithelial and mesenchymal components.
  • The stromal component was analyzed according to the presence of myxoid, hyaline, chondroid or calcified tissue.
  • RESULTS: Plasmacytoid cells were the most commonly found cellular type followed by fusiform and cuboidal cells.
  • Myxoid and chondroid stroma were the most frequently found mesenchymal-like tissue usually forming the so called myxochondroid stroma.
  • CONCLUSION: The knowledge of the immense variety of cells, architectures and morphological characteristics present in PA of the salivary gland is essential for a correct diagnosis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19179950.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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