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1. Lubiński J, Tarnowska C, Jaworowska E, Byrski T, Jakubowska A, Górski B, Bień S, Sygut J, Góźdź S, Siołek M, Sulikowski M, Lubiński J: Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort. Anticancer Res; 2008 Sep-Oct;28(5B):3011-3
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  • [Title] Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort.
  • BACKGROUND: The aim of the study was to examine whether pleomorphic adenoma of salivary glands can occur on the basis of constitutional BRCA-1 mutations.
  • MATERIALS AND METHODS: Two hundred and sixty-eight patients affected by mixed tumour of salivary glands were examined for occurrence of three BRCA-1 mutations dominating in Poland.
  • RESULTS: BRCA-1 mutation was detected in only one of the patients, a female affected by breast cancer and pleomorphic adenoma of parotid gland.
  • Parotid gland tumour showed clinical and histopathological features of typical pleomorphic adenoma with no morphological features of high-grade malignancy, which are characteristic of BRCA-1-dependent tumours.
  • CONCLUSION: Considering the low frequency of BRCA-1 mutation in the examined group and also the absence of features characterizing BRCA-1-dependent tumours in the only BRCA-1-positive case, pleomorphic adenoma of salivary glands should not be recognized as a BRCA-1 dependent tumour.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Genes, BRCA1. Mutation. Salivary Gland Neoplasms / genetics

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  • (PMID = 19031948.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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2. Nazarian Y, Talmi YP, Wolf M, Horowitz Z, Bedrin L, Pfeffer R, Kronenberg J: [Recurrent pleomorphic adenomas of the parotid gland--treatment and outcome]. Harefuah; 2007 Feb;146(2):82-4, 168
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  • [Title] [Recurrent pleomorphic adenomas of the parotid gland--treatment and outcome].
  • Epithelial tumors of the parotid gland comprise 3% of head and neck tumors, and 70%-80% of those are benign.
  • Pleomorphic adenoma is the most common tumor of the parotid gland.
  • Recurrence rate of pleomorphic adenomas (RPAs) following superficial parotidectomy was reported to be as high as 4%, sometimes associated with inadequate surgical treatment of the primary tumor.
  • These tumors have a very slow growth rate, and a ten-year follow-up period is mandatory.
  • Two patients (10%) had permanent paresis of a single branch of the facial nerve.
  • Seventeen out of 20 patients (85%) treated were disease-free after a follow-up period of 5 years.
  • [MeSH-major] Adenoma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17352271.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Israel
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3. Kariya S, Kosaka M, Orita Y, Akagi H, Nishizaki K: Adenocarcinoma ex pleomorphic adenoma of the head and neck: Report of five cases. Auris Nasus Larynx; 2006 Mar;33(1):43-6
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  • [Title] Adenocarcinoma ex pleomorphic adenoma of the head and neck: Report of five cases.
  • OBJECTIVE: Adenocarcinoma ex pleomorphic adenoma is a rare tumor, and thus the management of the tumor has not been established.
  • RESULTS: We present five cases of adenocarcinoma ex pleomorphic adenoma of the head and neck, including a rare case with nasopharyngeal adenocarcinoma ex pleomorphic adenoma.
  • There was no response to chemotherapy with nedaplatin and 5-FU, but the nasopharyngeal adenocarcinoma ex pleomorphic adenoma showed a remarkable regression after the administration of docetaxel.
  • CONCLUSION: The combination therapy that includes docetaxel may be a promising treatment for adenocarcinoma ex pleomorphic adenoma of the head and neck.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Mouth Neoplasms / pathology. Nasopharyngeal Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoadjuvant Therapy. Organoplatinum Compounds / administration & dosage. Palate / pathology. Parotid Gland / pathology. Retrospective Studies. Taxoids / administration & dosage

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  • (PMID = 16168590.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; 0 / Taxoids; 15H5577CQD / docetaxel; 8UQ3W6JXAN / nedaplatin; U3P01618RT / Fluorouracil
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4. Herrmann BW, Dehner LP, Lieu JE: Congenital salivary gland anlage tumor: a case series and review of the literature. Int J Pediatr Otorhinolaryngol; 2005 Feb;69(2):149-56
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  • [Title] Congenital salivary gland anlage tumor: a case series and review of the literature.
  • OBJECTIVE: To understand the clinical presentation and management of salivary gland anlage tumor (SGAT).
  • DESIGN AND METHODS: This case series includes a report of a newborn male who presented with acute airway obstruction secondary to a nasopharyngeal mass which was discovered in the course of the clinical evaluation.
  • The relevant literature from 1966 to the present has been reviewed through a Medline keyword search utilizing terms "salivary gland anlage tumor", "neonatal", and "nasopharynx."
  • CONCLUSIONS: Salivary gland anlage tumor of the nasopharynx is a rare cause of neonatal airway obstruction.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Nasopharyngeal Neoplasms / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 15656947.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 19
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5. Chakrabarti S, Bera M, Bhattacharya PK, Chakrabarty D, Manna AK, Pathak S, Maiti K: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc; 2010 Dec;108(12):833-6
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  • [Title] Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry.
  • Salivary gland swelling is a common and important problem.
  • Acute and chronic sialadenitis, different benign and malignant neoplasms are the common causes which present with salivary gland swelling.
  • Pre-operative core needle biopsy is hazardous and may damage facial nerve, lead to fistula formation or associated with tumour seeding.
  • The study was done with 40 cases of salivary gland swelling.
  • Out of 40 cases, 25 involved the parotid gland, most common age group affected was 20 - 40 years and male: female ratio was 5: 3.
  • Among these 3 cases, 2 were adenoid cystic carcinoma which was cytologically diagnosed as benign neoplasm (monomorphic adenoma).
  • One case of Warthin's tumour was cytologically diagnosed as pleomorphic adenoma.
  • FNAC is an important tool for early diagnosis of salivary gland lesions.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / pathology

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  • (PMID = 21661459.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] India
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6. Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N: Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. Oncol Rep; 2006 Apr;15(4):933-8
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  • [Title] Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors.
  • We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) or western blotting.
  • The mean expression levels of Bub1 mRNA and protein were higher in malignant tumors (0.12+/-0.028/1.75+/-0.53) than normal submandibular glands (0.042+/-0.014/0.19+/-0.044) and benign tumors (0.058+/-0.01/0.97+/-0.44).
  • We found a significant association between the level of Bub1 mRNA/protein expression and clinical stage in malignant tumors (Mann-Whitney U test, p=0.019/p=0.016).
  • A significant correlation was found between Bub1 mRNA/protein expression and the Ki-67 labeling index in salivary gland tumors (Spearman's correlation coefficient by rank test, p=0.026/p=0.002).
  • [MeSH-major] Cell Proliferation. Protein Kinases / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / genetics. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Blotting, Western. Carcinoma, Acinar Cell / genetics. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Neoplasm Staging. Proliferating Cell Nuclear Antigen / analysis. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16525682.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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7. Sato K, Ueda Y, Shimasaki M, Ozaki M, Nitta N, Chada K, Ishikawa Y, Katsuda S: Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. Pathol Res Pract; 2005;201(4):333-9
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  • [Title] Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature.
  • We report a case of pleomorphic adenoma (benign mixed tumor) of the breast, which is an extremely rare location for this tumor.
  • Examination of a 55-year-old woman unexpectedly revealed a mass measuring 0.8 cm in diameter in the subareolar region of the right breast.
  • Excisional biopsy was performed, and the tumor histologically showed pleomorphic adenoma composed of duct epithelial cells, myoepithelial cells, and a myxochondroid matrix.
  • The nuclei of the spindle and myoepithelial cells were immunoreactive for HMGI-C and HMGI(Y) proteins, indicating a histogenesis similar to pleomorphic adenoma of the salivary glands.
  • Sixty-nine cases of this type of tumor arising in the breast have been described previously.
  • Using imaging procedures, the tumor has occasionally been misdiagnosed as malignant clinically and even pathologically in frozen section diagnosis.
  • Careful diagnosis based on paraffin sections is required to avoid unnecessary aggressive surgery, and pathologists should include pleomorphic adenoma in the differential diagnosis of a demarcated, juxtaareolar, small hard mass.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Breast Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. HMGA1a Protein / analysis. HMGA2 Protein / analysis. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Middle Aged. Receptors, Estrogen / analysis

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  • (PMID = 15991841.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; 0 / Receptors, Estrogen; 124544-67-8 / HMGA1a Protein
  • [Number-of-references] 32
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8. Hervieu V, Scoazec JY: [Mixed endocrine tumors]. Ann Pathol; 2005 Dec;25(6):511-28
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  • [Title] [Mixed endocrine tumors].
  • Mixed endocrine tumors are tumors composed of at least two distinct tumor populations, one of which is endocrine.
  • Because of their rarity and unusual presentation, endocrine mixed tumors raise many problems of diagnosis, management and therapy.
  • Three main types of endocrine mixed tumors are recognized: The existence of these various types has been confirmed by recent molecular studies, even if the same studies have also shown that the histogenesis of a mixed endocrine tumor cannot be predicted from its histological features.
  • Composite tumors are the less rare mixed tumors.
  • The recent WHO classification recommends to restrict the term of composite endocrine tumor to the epithelial tumors containing at least 30% of obviously tumoral endocrine cells; some authors recommend to use higher thresholds, of at least 50%, in order to avoid overdiagnosis.
  • The endocrine component is usually well differentiated, easily identified by its suggestive histological features; the endocrine nature of tumor cells is confirmed by the immunodetection of specific endocrine and neuro-endocrine markers (such as chromogranin A and synaptophysin).
  • Mixed tumors can occur in every anatomical site; they are more frequent in organs containing endocrine cells in the normal state (especially the digestive tract and the pancreas), but they can also be observed in organs devoid of endocrine cells (such as the mammary gland).
  • The management of mixed endocrine tumors must take into account the more aggressive component.
  • Mixed tumors containing a well differentiated endocrine component and an adenocarcinomatous component are to be treated like adenocarcinomas.
  • Mixed tumors containing a poorly differentiated endocrine component must be considered as poorly differentiated endocrine carcinomas.
  • [MeSH-major] Digestive System Neoplasms / pathology. Endocrine Gland Neoplasms / pathology

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  • (PMID = 16735976.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 128
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9. Zielińska-Kaźmierska B, Sut M: [Adenoma pleomorphum of the parapharyngeal space -- a report of a case]. Otolaryngol Pol; 2005;59(6):861-3
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  • [Title] [Adenoma pleomorphum of the parapharyngeal space -- a report of a case].
  • [Transliterated title] Gruczolak wielopostaciowy przestrzeni przygardłowej prawej--opis przypadku.
  • Tumors of the parapharyngeal space are relatively rare lesions and accounts for 0,5% of all head and neck neoplasms.
  • Nearly 95% of tumors are primary neoplasms originating of anatomical structures containing the space.
  • Aproximately 80% of these tumors are benign lesions.
  • The most often diagnosed is pleomorphic adenoma.
  • The patients with a diagnosis of pleomorphic adenoma of parapharyngeal space are treated either in Laryngological or in Maxillo-Facial Surgery Departments.
  • The authors present a case of the patient treated because of pleomorphic adenoma of parapharyngeal space in the Cranial and Maxillo-Facial Surgery Department of Medical University of Lódź.
  • The size of the tumor required a wide surgical approach to the parapharyngeal space in order to reach its complete and safe removal.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Oropharyngeal Neoplasms / pathology

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  • (PMID = 16521452.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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10. Kamiyoshihara M, Ibe T, Takeyoshi I: Pleomorphic adenoma of the main bronchus in an adult treated using a wedge bronchiectomy. Gen Thorac Cardiovasc Surg; 2009 Jan;57(1):43-5
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  • [Title] Pleomorphic adenoma of the main bronchus in an adult treated using a wedge bronchiectomy.
  • Histopathologically, the tumor specimen was compatible with pleomorphic adenoma.
  • To our knowledge, only two cases of pleomorphic adenoma arising from the main bronchus have been reported in the English-language literature, and ours is the first report of lung-preserving surgery.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Bronchial Neoplasms / surgery. Pulmonary Surgical Procedures

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  • (PMID = 19160012.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Wang YY, Chen WL, Yang ZH, Huang ZQ, Li JS, Pan CB: [Effects of Ezrin gene on the proliferation and invasion activity of human salivary gland adenoid cystic carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2009 Apr;44(4):203-7
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  • [Title] [Effects of Ezrin gene on the proliferation and invasion activity of human salivary gland adenoid cystic carcinoma].
  • OBJECTIVE: To examine the expression of Ezrin in human salivary gland adenoid cystic carcinoma and investigate the effects of Ezrin gene silence on cell proliferation, apoptosis and invasion of adenoid cystic carcinoma (ACC)-M.
  • METHODS: The expression of Ezrin was detected by immunohistochemistry in normal salivary gland tissue (n=15), pleomorphic adenoma (n=40) and salivary gland adenoid cystic carcinoma (n=43).
  • RESULTS: The positive rate of Ezrin expression in ACC was significantly higher than that in normal salivary gland tissue and pleomorphic adenoma (P<0.05).
  • CONCLUSIONS: Over expression of Ezrin in human salivary gland adenoid cystic carcinoma may promote genesis, development and metastasis of tumors.
  • [MeSH-major] Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / pathology. Cytoskeletal Proteins / genetics. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Apoptosis. Cell Line, Tumor. Cell Proliferation. Gene Expression. Humans. Neoplasm Invasiveness. Neoplasm Metastasis

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  • (PMID = 19575999.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / ezrin
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12. Shelekhova KV, Kazakov DV, Hes O, Treska V, Michal M: Phosphaturic mesenchymal tumor (mixed connective tissue variant): a case report with spectral analysis. Virchows Arch; 2006 Feb;448(2):232-5
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  • [Title] Phosphaturic mesenchymal tumor (mixed connective tissue variant): a case report with spectral analysis.
  • We present a further case of a rare mesenchymal neoplasm termed phosphaturic mesenchymal tumor (mixed connective tissue variant).
  • The patient was a 42-year-old man with a long history of osteomalacia of unknown etiology with pathological bone fracture, abnormality of parathyroid glands, kyphosis, scoliosis, and spondylosis.
  • The tumor was surgically removed.
  • Grossly, the tumor was well circumscribed, unencapsulated, and had soft to dense consistency.
  • Histologically, the tumor was composed of primitive mesenchymal cells, osteoclast-like cells, and cells showing myofibroblastic features without cytologic atypia.
  • Unusual and hitherto unpublished prominent features were flower-like, slate-gray crystals, widespread hemosiderin deposits and large areas of hemorrhages, with the latter comprising approximately 60% of the tumor.

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  • (PMID = 16447065.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Mărgăritescu C, Mercuţ V, Mogoantă L, Florescu M, Simionescu C, Cionca L, Manea M: Salivary gland Basal cell adenomas--immunohistochemical evaluation of four cases and review of the literature. Rom J Morphol Embryol; 2005;46(1):29-40
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  • [Title] Salivary gland Basal cell adenomas--immunohistochemical evaluation of four cases and review of the literature.
  • OBJECTIVE: Evaluate the antigen profile of cellular population from basal cell adenomas.
  • MATERIAL AND METHODS: Histopathological and immunohistochemical evaluation of four-salivary gland basal cell adenomas; the pathological samples were provided by the Oral Maxilla Facial Surgery Department of the Clinical County Hospital from Craiova.
  • RESULTS: All basal cell adenoma exhibit differentiation toward 3 cell phenotypes: ductal luminal, basal and myoepithelial.
  • CONCLUSIONS: The antigen profile of these tumors closely regard with other variants of salivary gland adenomas, such as pleomorphic adenoma and myoepithelioma.
  • So, we can conclude that these tumors had a common origin, most probably from intercalated ducts and the proportion of those 3 cellular types, their cytoarchitectural arrangements and the quantity of extracellular matrix production can do the differentiation between them.
  • [MeSH-major] Adenoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16286982.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen
  • [Number-of-references] 66
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14. Wang YY, Chen WL, Zhang WX, Bai ZB, Huang ZQ, Li JS: [Ezrin and inducible nitric oxide synthase in malignant proliferation of salivary gland pleomorphic adenoma]. Ai Zheng; 2009 Oct;28(10):1072-6
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  • [Title] [Ezrin and inducible nitric oxide synthase in malignant proliferation of salivary gland pleomorphic adenoma].
  • BACKGROUND AND OBJECTIVE: Ezrin and inducible nitric oxide synthase (iNOS) may play an important role in regulating tumor proliferation, invasion, and metastasis.
  • This study was to investigate the expression of Ezrin and iNOS and their correlation to malignant proliferation of salivary gland pleomorphic adenoma (PA).
  • METHODS: Expressions of Ezrin, iNOS and nuclear Ki-67 antigen were detected by immunohistochemistry in common type (n=40), active type (n=25) and malignant (n=11) pleomorphic adenoma.
  • RESULTS: Expressions of Ezrin, iNOS in common type, active type and malignant pleomorphic adenoma were gradually increased (P<0.05).
  • CONCLUSION: Overexpression of Ezrin and iNOS may promote proliferation and malignant transformation of salivary gland pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Cell Transformation, Neoplastic / metabolism. Cytoskeletal Proteins / metabolism. Nitric Oxide Synthase Type II / metabolism. Salivary Gland Neoplasms / metabolism


15. Furuse C, Cury PR, de Araújo NS, de Araújo VC: Application of two different clones of vimentin to the diagnosis of salivary gland tumors. Appl Immunohistochem Mol Morphol; 2006 Jun;14(2):217-9
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  • [Title] Application of two different clones of vimentin to the diagnosis of salivary gland tumors.
  • The authors observed different expressions of vimentin in salivary gland tumors using two clones of this antibody.
  • This study was undertaken to show these differences comparing the immunoexpression of two clones of vimentin (V9 and Vim 3B4, DAKO, Carpenteria, CA) using 10 pleomorphic adenomas, 10 adenoid cystic carcinomas, and 4 epithelial/myoepithelial carcinomas of the salivary glands.
  • The V9 clone of vimentin was much more efficient in demonstrating the myoepithelial cells in the different tumors studied.
  • The Vim 3B4 clone was capable of detecting some myoepithelial cells, the plasmacytoid or modified myoepithelial cells in the pleomorphic adenoma, but was very weak in epithelial/-myoepithelial carcinomas.

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  • (PMID = 16785793.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Vimentin
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16. Gamboa-Dominguez A, Dominguez-Fonseca C, Chavarri-Guerra Y, Vargas R, Reyes-Gutierrez E, Green D, Quintanilla-Martinez L, Luber B, Busch R, Becker KF, Becker I, Höfler H, Fend F: E-cadherin expression in sporadic gastric cancer from Mexico: exon 8 and 9 deletions are infrequent events associated with poor survival. Hum Pathol; 2005 Jan;36(1):29-35
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  • Aberrant expression and mutation of E-cadherin is frequent in gastric carcinoma (GC) especially of the diffuse type.
  • One hundred seventy-seven gastrectomies from Mexican mestizo patients with intestinal (53), mixed (55), or diffuse (69) GC were included.
  • Immunohistochemistry against wild-type E-cadherin (clone 36) and against 2 mutation-specific antibodies (MSA) recognizing mutant CDH1 lacking exon-8 (del 8) or exon-9 (del 9) were performed.
  • Staining was correlated with histotype, tumor node metastasis stage, and follow-up.
  • Abnormal or absent E-cadherin expression (clone 36) was identified in 84% GC, predominantly in diffuse or mixed tumors (P = 0.004) in advanced stages (P = 0.003).
  • No survival differences at 1 and 2 years were observed among patients showing normal, abnormal, or absent wild type E-cadherin expression.
  • In 140 patients, dead from the disease or alive with the disease, the survival at 1 and 2 years was 37% versus 17% and 14% versus 0 for patients without and with del 8/9 positivity, respectively (log rank P = 0.01).
  • However, exon 8 or 9 deletions were observed in only 5.3% tumors in this series from Mexico, at a lower rate than previously published, but associated with a worse prognosis.

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  • (PMID = 15712179.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; EC 1.1.- / Carbohydrate Dehydrogenases; EC 1.1.99.18 / cellobiose-quinone oxidoreductase
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17. Furuse C, Miguita L, Rosa AC, Soares AB, Martinez EF, Altemani A, de Araújo VC: Study of growth factors and receptors in carcinoma ex pleomorphic adenoma. J Oral Pathol Med; 2010 Aug 1;39(7):540-7
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  • [Title] Study of growth factors and receptors in carcinoma ex pleomorphic adenoma.
  • Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant salivary gland tumor derived from a pre-existing pleomorphic adenoma.
  • Slides were qualitatively and semi-quantitatively evaluated according to the percentage of stained tumor cells from 0 to 3 (0 = less than 10%; 1 = 10-25%; 2 = 25-50%; 3 = more than 50% of cells).
  • Malignant epithelial cells starting with in situ areas showed stronger expression than luminal cells of pleomorphic adenoma for all antibodies.
  • Altogether this data infers that these factors may contribute to cell proliferation during initial phases of the tumor.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Intercellular Signaling Peptides and Proteins / analysis. Parotid Neoplasms / pathology. Receptors, Growth Factor / analysis
  • [MeSH-minor] Adult. Aged. Carcinoma in Situ / pathology. Cell Proliferation. Coloring Agents. Disease Progression. Epithelial Cells / pathology. Female. Fibroblast Growth Factors / analysis. Hepatocyte Growth Factor / analysis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Protein-Serine-Threonine Kinases / analysis. Proto-Oncogene Proteins c-met / analysis. Receptor, Epidermal Growth Factor / analysis. Receptor, Fibroblast Growth Factor, Type 1 / analysis. Receptor, Fibroblast Growth Factor, Type 2 / analysis. Receptor, IGF Type 1 / analysis. Receptors, Transforming Growth Factor beta / analysis. Submandibular Gland Neoplasms / pathology. Transforming Growth Factor beta1 / analysis

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  • (PMID = 20149060.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Intercellular Signaling Peptides and Proteins; 0 / Receptors, Growth Factor; 0 / Receptors, Transforming Growth Factor beta; 0 / Transforming Growth Factor beta1; 62031-54-3 / Fibroblast Growth Factors; 67256-21-7 / Hepatocyte Growth Factor; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / FGFR2 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 2; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor
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18. Kebebew F, Kotisso B: A rare case of squamous cell ex-pleomorphic adenoma of the submandibular salivary gland. Ethiop Med J; 2008 Oct;46(4):415-8
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  • [Title] A rare case of squamous cell ex-pleomorphic adenoma of the submandibular salivary gland.
  • We herein report a case of Carcinoma ex pleomorphic adenoma, a rare neoplasm of the submandibular salivary gland.
  • Histopathologic study confirmed squamous cell ex pleomorphic adenoma of the submandibular salivary gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 19271409.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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19. Kawahara A, Harada H, Akiba J, Yokoyama T, Kage M: Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfalls. Diagn Cytopathol; 2007 Feb;35(2):85-90
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  • [Title] Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfalls.
  • We retrospectively studied the cytological features of aspiration cytology in 12 cases of basal cell adenoma (BCA) and 5 cases mistakenly diagnosed as BCA.
  • On macroscopic findings, the 12 cases of BCA included 7 cases of solid type and 5 cases of cystic type.
  • The characteristic cytological features of solid type BCA were three-dimensional clusters in 71%, sharp-angle small clusters in 86%, basement membrane- like material in 71%, and cell crush in 86%.
  • In contrast, 3 of the 5 cystic type BCA cases showed inadequate cellular components or no basaloid tumor cells, and the cytological diagnosis of BCA could not be determined.
  • In the 5 cases misdiagnosed as BCA, there were 2 cases of pleomorphic adenoma, 2 cases of benign lymphoepithelial cyst, and 1 case of basal cell adenocarcinoma.
  • Accurate differential cytological diagnosis of BCA is relatively easy to determine the solid type BCA, but is more difficult for cystic type BCA.
  • [MeSH-major] Adenoma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17230571.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Ayadi L, Chaâbouni S, Dhouib H, Abbès K, Dhouib M, Makni S, Abdelmoula M, Ghorbel A, Khabir A, Boudawara T: [Polymorphous low-grade adenocarcinoma: about two cases]. Tunis Med; 2009 Jun;87(6):403-6
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  • [Transliterated title] Adénocarcinome polymorphe de bas grade: à propos de deux cas.
  • BACKGROUND: Polymorphous low-grade adenocarcinoma (APBG) is a variant of malignant tumour of minor salivary glands usually arising in the palate.
  • AIM: Our aim is to discuss morphology, evolution and differential diagnosis of this rare tumour.
  • CASE REPORTS: The first case interested a 65-year-old-woman admitted for a two-months-history of a right submaxillary swelling.
  • Examination found a tumour of the right side of the palate.
  • A biopsy concluded to a pleomorphic adenoma.
  • The second case interested a 57-year-old-woman who consulted for a 12-year-history of a swelling of the lower lip.
  • The patient had no evidence of disease with a follow-up of 54 months.
  • CONCLUSION: APBG is characterised by a morphologic diversity and a cytologic uniformity that may cause a diagnostic dilemma especially with adenoid cystic carcinoma and pleomorphic adenoma.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor


21. Khoo SG, Keogh IJ, Timon C: The use of botulinum toxin in Frey's Syndrome. Ir Med J; 2006 May;99(5):136-7
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  • [MeSH-major] Adenoma, Pleomorphic / surgery. Botulinum Toxins, Type A / therapeutic use. Parotid Neoplasms / surgery. Postoperative Complications / drug therapy. Sweating, Gustatory / drug therapy

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  • (PMID = 16892916.001).
  • [ISSN] 0332-3102
  • [Journal-full-title] Irish medical journal
  • [ISO-abbreviation] Ir Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] EC 3.4.24.69 / Botulinum Toxins, Type A
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22. Swelam W, Ida-Yonemochi H, Maruyama S, Ohshiro K, Cheng J, Saku T: Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma. Virchows Arch; 2005 Jun;446(6):653-62
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  • [Title] Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma.
  • To better understand the poorly vascularized background of the stroma of pleomorphic adenomas, we attempted to determine the expression of molecules related to blood vessels and hypoxic conditions in pleomorphic adenoma.
  • Surgical specimens and tumor cells in primary culture of salivary pleomorphic adenomas were used for immunohistochemistry for CD31, vascular endothelial growth factor (VEGF) and its receptors Flk-1 and Flt-1, as well as for hypoxia markers, such as hypoxia-inducible factor-1alpha (HIF-1alpha) and lactate dehydrogenase-1 (LDH).
  • In addition to co-immunolocalization with CD31+ vascular endothelial cells, VEGF and its receptors were demonstrated in normal duct epithelial and myoepithelial cells as well as in tumor cells in ductal structures and in myxochondroid stromata.
  • Immunofluorescence signals for VEGF and others were confirmed in pleomorphic adenoma cells in culture.
  • RT-PCR results showed that there were at least four splicing modes of the VEGF gene, among which VEGF(121) was most enhanced, and higher HIF-1alpha levels in pleomorphic adenomas.
  • The results suggest that pleomorphic adenoma cells produce VEGF in several functional forms for their own proliferation or differentiation, and that the VEGF expression is controlled by hypoxic circumstances of poorly vascularized pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Hypoxia / physiopathology. Salivary Gland Neoplasms / blood supply. Vascular Endothelial Growth Factor A / genetics. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Alternative Splicing. Antigens, CD31 / metabolism. Biomarkers, Tumor / analysis. Fluorescent Antibody Technique. Humans. Hypoxia-Inducible Factor 1, alpha Subunit. Image Processing, Computer-Assisted. Immunohistochemistry. Proteins / metabolism. RNA, Messenger / analysis. Receptor Protein-Tyrosine Kinases / metabolism. Receptor, Fibroblast Growth Factor, Type 1. Receptors, Fibroblast Growth Factor / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors / metabolism. Vascular Endothelial Growth Factor Receptor-1

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  • (PMID = 15856293.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Proteins; 0 / RNA, Messenger; 0 / Receptors, Fibroblast Growth Factor; 0 / Transcription Factors; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / FLT1 protein, human; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-1
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23. Queimado L, Obeso D, Hatfield MD, Yang Y, Thompson DM, Reis AM: Dysregulation of Wnt pathway components in human salivary gland tumors. Arch Otolaryngol Head Neck Surg; 2008 Jan;134(1):94-101
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  • [Title] Dysregulation of Wnt pathway components in human salivary gland tumors.
  • OBJECTIVES: To determine the expression level of the Wnt components-WIF1 (Wnt inhibitory factor 1), WNT1, and beta-catenin-in salivary gland tumor cells and to investigate the mechanisms that contribute to activation of the Wnt pathway in human salivary gland tumors.
  • DESIGN: The expression of WIF1, WNT1, and beta-catenin in salivary gland normal tissue and tumor cell lines was analyzed by reverse transcription-polymerase chain reaction and Western blot analysis.
  • SUBJECTS: Samples were obtained from 6 normal salivary glands and 10 cell lines established from primary benign and malignant salivary gland tumors.
  • RESULTS: The expression of WIF1 was high in normal salivary gland tissue but was significantly down-regulated in all salivary gland tumor cell lines analyzed (P < .001).
  • The WIF1 rearrangements were recurrent but rare in salivary gland tumors.
  • Expression of WNT1 protein was undetectable in normal tissue but readily detectable by Western blot analysis in all salivary gland tumor cell lines. beta-Catenin messenger RNA expression was significantly up-regulated in salivary gland tumor cells.
  • A positive linear correlation between beta-catenin and PLAG1 (pleomorphic adenoma gene 1) gene expression was observed.
  • CONCLUSIONS: This is the first report (to our knowledge) showing down-regulation of an antagonist of the Wnt pathway, WIF1, and up-regulation of a Wnt agonist, WNT1, in salivary gland tumor cells.
  • This dysregulation of WNT1 and WIF1 expression, coupled with the observed increase in beta-catenin transcription, may consequently promote salivary gland oncogenesis.
  • Our data support the study of the Wnt pathway as a putative therapeutic target for salivary gland cancer.
  • [MeSH-major] Salivary Gland Neoplasms / metabolism. Wnt Proteins / metabolism
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / metabolism. Blotting, Western. DNA-Binding Proteins / metabolism. Down-Regulation. Humans. Repressor Proteins / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured. Up-Regulation. beta Catenin / metabolism

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  • (PMID = 18209144.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR018741
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / PLAG1 protein, human; 0 / Repressor Proteins; 0 / WIF1 protein, human; 0 / Wnt Proteins; 0 / beta Catenin
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24. Katayam N, Tokuda A, Nakatsumi Y, Oribe Y, Fujimura M: [A case of malignant mesothelioma presenting with recurrent pneumothorax]. Nihon Kokyuki Gakkai Zasshi; 2006 Nov;44(11):807-11
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  • Although pneumothorax was treated successfully, increased pleural effusion, pleural thickening and subcutaneal tumor at the thoracic drainage suture site developed.
  • The histological examination of the biopsied subcutaneous tumor showed mixed type malignant pleural mesothelioma.
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Disease Progression. Fatal Outcome. Humans. Male. Picibanil / therapeutic use. Recurrence

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  • (PMID = 17144577.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 39325-01-4 / Picibanil
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25. Okisaka S: [Easy ophthalmic pathology]. Nippon Ganka Gakkai Zasshi; 2005 Jul;109(7):393-9
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  • [MeSH-major] Adenoma, Pleomorphic / pathology. Cornea / pathology. Corneal Dystrophies, Hereditary / pathology. Eye Neoplasms / pathology. Keratosis, Seborrheic / pathology. Lacrimal Apparatus / pathology

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  • (PMID = 16116684.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 11
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26. Lee SK, Rho BH, Won KS: Parotid incidentaloma identified by combined 18F-fluorodeoxyglucose whole-body positron emission tomography and computed tomography: findings at grayscale and power Doppler ultrasonography and ultrasound-guided fine-needle aspiration biopsy or core-needle biopsy. Eur Radiol; 2009 Sep;19(9):2268-74
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  • The results of ultrasound-guided fine-needle aspiration biopsy (FNAB) (n = 9) and core-needle biopsy (CNB) (n = 3) were Warthin tumor in 10 cases, and pleomorphic adenoma and chronic inflammation in one each.
  • SUV(max) was 7.0-21.0 g/mL (average 13.7 g/mL) for Warthin tumor, 6.8 g/mL for pleomorphic adenoma, and 7.3 g/mL for chronic inflammation.
  • Parotid incidentaloma identified by 18F-FDG PET/CT during workup of various malignancies elsewhere does not necessarily signify primary or metastatic malignancy, but indicates a high likelihood of benign lesions, particularly Warthin tumor.
  • Such lesions should be evaluated thoroughly by US and ultrasound-guided FNAB or CNB if parotid disease would change the patient's treatment plan.
  • [MeSH-major] Adenoma / diagnosis. Biopsy, Fine-Needle / methods. Fluorodeoxyglucose F18. Parotid Neoplasms / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods. Ultrasonography, Doppler / methods

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  • [Cites] Laryngoscope. 2001 Nov;111(11 Pt 1):1989-92 [11801984.001]
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  • (PMID = 19396445.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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27. Tarakji B, Nassani MZ: Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons. Kulak Burun Bogaz Ihtis Derg; 2010 May-Jun;20(3):129-36
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  • [Title] Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons.
  • OBJECTIVES: This study aims to highlight the current points of view regarding the management of pleomorphic adenomas among oral and maxillofacial surgeons in the United Kingdom.
  • The survey evaluated the surgical experience of the surgeon, the preferred surgical treatment of a newly diagnosed 3 cm diameter pleomorphic adenoma in the superficial lobe of the parotid gland in an adult and a child, and the treatment options of pleomorphic salivary adenoma (PSA) with the four following scenarios: (i) PSA with complete excision or incomplete excision;.
  • (ii) PSA with carcinoma in situ (atypical pleomorphic adenoma) with complete excision or incomplete excision;.
  • The results showed that there was no significant difference in the opinions of the respondents regarding treatment of pleomorphic adenoma in both adults and children.
  • There was a consensus on complete excision for the treatment of carcinoma in situ (atypical pleomorphic adenoma) or PSA with non-invasive malignant transformation.
  • CONCLUSION: This survey shows that superficial parotidectomy is the standard treatment method for primary pleomorphic adenoma in children and adults.
  • Surgery combined with radiotherapy is the preferred option in the case of multinodular recurrence, and surgery alone is recommended in the case of a solitary recurrence.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Health Care Surveys. Parotid Neoplasms / surgery
  • [MeSH-minor] Adult. Child. Combined Modality Therapy. Data Collection. Great Britain. Humans. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Otolaryngology. Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery. Societies, Medical. Surgical Procedures, Operative / methods

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  • (PMID = 20465538.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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28. Ellies M, Schaffranietz F, Arglebe C, Laskawi R: Tumors of the salivary glands in childhood and adolescence. J Oral Maxillofac Surg; 2006 Jul;64(7):1049-58
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  • [Title] Tumors of the salivary glands in childhood and adolescence.
  • PURPOSE: We report on 52 juvenile and adolescent patients with benign and malignant tumors of the salivary glands.
  • RESULTS: Benign tumors had their highest incidence in puberty and postpuberty.
  • Forty patients (20 girls and 20 boys; 77%) had benign growths and 12 patients (9 girls and 3 boys; 23%) suffered from malignant neoplasms.
  • After surgery for benign tumors we saw no postoperative recurrences in long-term follow-up.
  • In the group of malignant tumors, 8 patients (66.7%) survived their disease in the long-term follow-up.
  • CONCLUSIONS: Salivary gland diseases are rare in childhood and adolescence.
  • This is particularly true for the malignant parotid tumors that are more frequent in juvenile patients, a fact that has to be considered in diagnosis and therapy.
  • [MeSH-major] Adenoma, Pleomorphic / therapy. Carcinoma / therapy. Neoplasm Recurrence, Local / therapy. Salivary Gland Neoplasms / therapy
  • [MeSH-minor] Adolescent. Age Factors. Child. Female. Follow-Up Studies. Humans. Male. Parotid Neoplasms / diagnosis. Parotid Neoplasms / epidemiology. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy. Submandibular Gland Neoplasms / diagnosis. Submandibular Gland Neoplasms / epidemiology. Submandibular Gland Neoplasms / pathology. Submandibular Gland Neoplasms / therapy. Survival Analysis. Treatment Outcome

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  • (PMID = 16781337.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Farah-Klibi F, Ferchiou M, Kourda J, El Amine O, Ferjaoui M, Ben Jilani S, Zermani R: [Parotid basal cell adenoma of membranous type]. Tunis Med; 2009 Feb;87(2):149-51
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  • [Title] [Parotid basal cell adenoma of membranous type].
  • [Transliterated title] Adenome a cellules basales de type membraneux de la parotide.
  • INTRODUCTION: Basal cell adenoma (BCA) is a rare benign neoplasm characterized by the basaloid appearance of the tumour cells and the lack of myxo-chondroid stromal component present in pleomorphic adenoma.
  • AIM: We report a case of basal cell adenoma of membranous type, highly suspected of malignancy because of the presence of mediastinal lymph nodes and pulmonary nodules which finally were related to an associated sarcoidosis.
  • So the diagnosis of metastatic malignant salivary gland tumor was suspected.
  • Finally, the histological examination concluded to a basal cell adenoma of membranous type with sarcoidosis granulomas in the parotid and in the lymph nodes.
  • CONCLUSION: The BCA is a benign tumor located generally in the parotid gland.
  • When the malignancy is suspected, like in our case, this tumor must be differentiated from the basal cell adenocarcinoma using histological criteria.
  • [MeSH-major] Adenoma / diagnosis. Parotid Neoplasms / diagnosis. Sarcoidosis / diagnosis

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  • (PMID = 19522450.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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30. Obara K, Ide F, Mishima K, Inoue H, Yamada H, Hayashi Y, Saito I: Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis. Pathobiology; 2006;73(5):261-70
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  • [Title] Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis.
  • OBJECTIVE: To understand the salivary gland pathobiology, we established an immortalized duct/basal cell line (MSE) from the submandibular glands of p53-deficient mice.
  • RESULTS: Inoculation of a mixture of MSE and Matrigel reconstructed polarized ducts whereas cotransplantation of MSE with both Matrigel and NIH3T3 (3T3) cells developed mixed tumors of adenoma and sarcoma.
  • A daughter adenoma line (MSA) showed some transformed phenotype in vitro, but was marginally tumorigenic in vivo.
  • Notably, pleomorphic adenoma gene 1 (PLAG1) was expressed in MSA but not in MSE.
  • CONCLUSION: The intrinsic tumorigenic programs of p53 null salivary epithelium are promoted by 3T3 sarcoma-derived IGF-IIin a paracrine manner through overexpression of PLAG1 and IGF-IR.
  • [MeSH-major] Cell Communication / physiology. Cell Transformation, Neoplastic / metabolism. Epithelial Cells / metabolism. Salivary Glands / metabolism. Stromal Cells / metabolism. Tumor Suppressor Protein p53 / deficiency
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Animals. Blotting, Western. Cell Line. Collagen. DNA-Binding Proteins / metabolism. Drug Combinations. Female. Immunohistochemistry. Laminin. Mice. Mice, Transgenic. Microscopy, Electron, Transmission. Neoplasms, Experimental / metabolism. Neoplasms, Experimental / pathology. Proteoglycans. Receptor, IGF Type 1 / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology. Sarcoma / metabolism. Sarcoma / pathology

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 17314497.001).
  • [ISSN] 1015-2008
  • [Journal-full-title] Pathobiology : journal of immunopathology, molecular and cellular biology
  • [ISO-abbreviation] Pathobiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Drug Combinations; 0 / Laminin; 0 / Plag1 protein, mouse; 0 / Proteoglycans; 0 / Tumor Suppressor Protein p53; 119978-18-6 / matrigel; 9007-34-5 / Collagen; EC 2.7.10.1 / Receptor, IGF Type 1
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31. Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P: Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg; 2006 Jul;132(7):788-93
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  • [Title] Metastasizing pleomorphic salivary adenoma.
  • OBJECTIVE: To address questions about the etiology, behavior, optimal treatment, and prognosis of metastasizing pleomorphic adenoma (MPA), we undertook a review of the literature (1953-2005) and constructed a virtual series of all identified cases of MPA, metastatic lesions that are very occasionally identified in patients with a history of pleomorphic salivary adenoma and, on detailed pathological evaluation, found to exhibit all the histological hallmarks of the preceding benign lesions.
  • There was an overwhelming history of incomplete surgery for pleomorphic salivary adenoma.
  • There was significant morbidity and mortality from distant disease, with 5-year disease-specific and disease-free survival of 58% and 50%, respectively.
  • Developing distant lesions within 10 years of the primary tumor and presence of metastases in multiple sites were independent predictors of survival on Cox regression analysis.
  • Metastatic disease carries significant morbidity and mortality and should be treated surgically when feasible.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16847191.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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32. Yuan WH, Hsu HC, Chou YH, Hsueh HC, Tseng TK, Tiu CM: Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands. Clin Imaging; 2009 Sep-Oct;33(5):348-53
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  • [Title] Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • Our aim was to assess the specific ultrasonic characteristics of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  • METHODS: We retrospectively reviewed and analyzed the ultrasonographic (US) features of 19 pleomorphic adenomas in 16 patients and 29 Warthin's tumors in 20 patients.
  • The features included tumor size, echotexture, boundary, and shape on gray-scale US imaging and grading and distribution of tumor vascularity on color Doppler ultrasound (CDU).
  • Most of the tumors (87.5%) were >or=10 mm, and 93.8% were well defined.
  • Only two of 29 Warthin's tumors had the highest grade of vascularity (+++).
  • Predominantly central blood flow was present in 58.6% of Warthin's tumors and 42.1% of pleomorphic adenomas.
  • Lobulated margin (shape) was noted in 84.2% of pleomorphic adenomas and 51.7% of Warthin's tumors (P<.05).
  • Anechoic cystic components were present in 13 (44.8%) of 29 Warthin's tumors and in only one pleomorphic adenoma (1/19, 5.3%) (P<.01).
  • CONCLUSION: Most pleomorphic adenomas were lobulated.
  • Internal anechoic cystic components were absent from pleomorphic adenomas but present in some Warthin's tumors.
  • The grading and distribution of blood flow signals on CDU provided only limited additional diagnostic information for distinguishing pleomorphic adenomas from Warthin's tumors.
  • Gray-scale ultrasonography is a useful method for evaluating and distinguishing pleomorphic adenomas from Warthin's tumors.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Echocardiography, Doppler, Color / methods. Salivary Gland Neoplasms / ultrasonography

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  • (PMID = 19712813.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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33. Nouraei SA, Ismail Y, Ferguson MS, McLean NR, Milner RH, Thomson PJ, Welch AR: Analysis of complications following surgical treatment of benign parotid disease. ANZ J Surg; 2008 Mar;78(3):134-8
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  • [Title] Analysis of complications following surgical treatment of benign parotid disease.
  • BACKGROUND: The objective of the study was to study the incidence of, and risk factors for developing complications following parotidectomy for benign disease, to improve preoperative patient counselling and better inform future surgical management.
  • METHODS: An 11-year retrospective review of 162 parotidectomies for benign disease, collecting and analysing data about presentation, investigations, surgical treatment, postoperative facial nerve function, Frey's syndrome and other surgical complications.
  • The commonest pathology was benign pleomorphic adenoma (43%), followed by Warthin's tumour (30%) and chronic sialadenitis (22%).
  • Sialadenitis was a significant risk factor for facial nerve palsy and increased the incidence of salivary fistulas.
  • Operations for Warthin's tumour were associated with an increased risk of dysfunction of the cervical branch of the nerve.
  • [MeSH-major] Facial Paralysis / epidemiology. Otorhinolaryngologic Surgical Procedures / adverse effects. Parotid Diseases / pathology. Parotid Diseases / surgery. Parotid Gland / surgery. Postoperative Complications / epidemiology

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  • (PMID = 18269474.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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34. Soares AB, de Araújo VC, Juliano PB, Altemani A: Angiogenic and lymphangiogenic microvessel density in recurrent pleomorphic adenoma. J Oral Pathol Med; 2009 Sep;38(8):623-9
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  • [Title] Angiogenic and lymphangiogenic microvessel density in recurrent pleomorphic adenoma.
  • BACKGROUND: Recurrent pleomorphic adenoma (RPA) is an uncommon and challenging disease.
  • The aim of this study was to determine if there is a difference between RPA and the pleomorphic adenoma (PA) without recurrence related to tumor blood and lymphatic vascularization.
  • Moreover, we compared the microvessel density (MVD) between cell-rich areas (predominance of epithelial cells) and cell-poor areas (predominance of myxoid and chondroid areas) of the stroma of PA and RPA.
  • RESULTS: Comparing no recurrent with recurrent tumor, no significant difference was found in terms of lymphatic vessel density, MVD, and proliferation index.
  • CONCLUSION: This study shows that although RPA presents more aggressive clinical behavior than PA, there is no difference between tumor blood and lymphatic vascularization, suggesting that there is no correlation between vascularity and risk of recurrence.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local / blood supply. Neovascularization, Pathologic / pathology. Parotid Neoplasms / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 19563505.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Ki-67 Antigen
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35. Vacchi-Suzzi M, Bocciolini C, Bertarelli C, Dall'Olio D: Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas. Ann Otol Rhinol Laryngol; 2010 Oct;119(10):677-83
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  • [Title] Ki-67 proliferation rate as a prognostic marker in major salivary gland carcinomas.
  • OBJECTIVES: The study was performed to evaluate the prognostic relevance of cell proliferation associated with Ki-67/ Mib-1 immunostaining in malignant tumors of the major salivary glands.
  • METHODS: Cell proliferation was evaluated by Mib-1 antibody against Ki-67 antigen in 41 patients with cancer of the parotid or submandibular glands, including 14 acinic cell carcinomas, 12 ductal carcinomas, 7 mucoepidermoid carcinomas, 5 carcinomas ex pleomorphic adenoma, 1 adenoid cystic carcinoma, 1 undifferentiated carcinoma, and 1 polymorphous low-grade adenocarcinoma.
  • RESULTS: Patients with Ki-67 values of more than 15% and those with Ki-67 values of 15% or less differed both in disease-free survival (p < 0.001) and in overall survival (p < 0.001).
  • CONCLUSIONS: To our knowledge, this is the first study to stratify different risk classes in early T1-T2 or N0 malignant tumors of the major salivary glands that identified aggressive lesions with elevated Ki-67 expression at an initial stage.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers / analysis. Carcinoma, Acinar Cell / mortality. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Ductal / mortality. Carcinoma, Mucoepidermoid / mortality. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Parotid Neoplasms / mortality. Prognosis. Salivary Gland Neoplasms / mortality. Submandibular Gland Neoplasms / mortality

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  • (PMID = 21049853.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Ki-67 Antigen
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36. De Backer A, Madern GC, Hakvoort-Cammel FG, Haentjens P, Oosterhuis JW, Hazebroek FW: Study of the factors associated with recurrence in children with sacrococcygeal teratoma. J Pediatr Surg; 2006 Jan;41(1):173-81; discussion 173-81
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  • PURPOSE: The aim of this study was to explore effects of (1) histological involvement of resection margins with microscopic residue, (2) incomplete removal of coccyx, and (3) tumor spillage on recurrence and on survival in children operated upon for sacrococcygeal teratoma (SCT).
  • Thirty-six percent of tumors were Altman type I, 27% type II, 18% type III, and 18% type IV.
  • Histologically, mature teratoma was observed in 48 patients, immature teratoma in 11, yolk sac tumor (YST) in 9, embryonal carcinoma in one, and mixed tumor in one.
  • Tumor recurrence was observed in 5 patients, 2 of whom died.
  • Of 2 patients with initially immature teratoma grade I, one relapsed with a benign lesion and one with YST leading to death.
  • Histological analysis of resection margins showed tumoral involvement in 11 patients (and also in one patient after resection of a recurrent tumor).
  • Intraoperative tumor spillage presented in 2 patients, who both died of metastatic disease.
  • One of 5 patients whose coccyx had not been removed died of metastatic disease.
  • One with immature teratoma developed a benign recurrent tumor.
  • Spillage of cyst fluid was never associated with recurrence, unlike spillage of tumor and absence of removal of coccyx.

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  • (PMID = 16410129.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Allon I, Vered M, Buchner A, Dayan D: Stromal differences in salivary gland tumors of a common histopathogenesis but with different biological behavior: a study with picrosirius red and polarizing microscopy. Acta Histochem; 2006;108(4):259-64
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  • [Title] Stromal differences in salivary gland tumors of a common histopathogenesis but with different biological behavior: a study with picrosirius red and polarizing microscopy.
  • Salivary gland neoplasms - pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma - share a common histogenetic trait, but differ markedly in their biological properties.
  • The objective of the study was to assess the polarization colors of picrosirius red-stained stromal collagen fibers in these salivary gland neoplasms to evaluate their possible role in the histopathogenesis of the tumors and to evaluate the potential usefulness of this approach as a diagnostic tool.
  • Ten cases of each tumor type and 10 cases of mucous extravasation phenomenon (control) were examined using picrosirius red staining and polarizing microscopy.
  • Results showed a similar thin fiber distribution in all tumor types and controls (82-88% green-yellow, 12-18% yellow-orange, p>0.05).
  • Thick fibers showed a different distribution in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma (approximately 50% green-yellow) compared to pleomorphic adenoma and mucous extravasation phenomenon (approximately 13% green-yellow) (p=0.001).
  • We conclude that with picrosirius red staining and polarizing microscopy, stromal collagen fibers differ significantly in pleomorphic adenoma from those in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma, but not from mucous extravasation phenomenon.
  • Similarity between polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma may indicate that these tumor types represent a single entity with a broad spectrum of biological behavior.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Azo Compounds. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology. Stromal Cells / pathology

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  • (PMID = 16899283.001).
  • [ISSN] 0065-1281
  • [Journal-full-title] Acta histochemica
  • [ISO-abbreviation] Acta Histochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Azo Compounds; 0 / Coloring Agents; 0 / Fibrillar Collagens; 1294D5G72N / C.I. direct red 80
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38. Perez DE, de Almeida OP, Vargas PA: Polarizing light microscopy for identifying chondroid tissue in aspirates of pleomorphic adenoma. Acta Cytol; 2007 May-Jun;51(3):489-91
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  • [Title] Polarizing light microscopy for identifying chondroid tissue in aspirates of pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Microscopy, Polarization. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • (PMID = 17536564.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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39. Siddiqui NH, Wu SJ: Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report. Diagn Cytopathol; 2005 Apr;32(4):229-32
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  • [Title] Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report.
  • Although pleomorphic adenomas (PAs) usually can be diagnosed very accurately with fine-needle aspiration biopsy (FNAB), even this common salivary gland neoplasm can be diagnostically challenging and cause pitfalls in cytodiagnosis.
  • Here, we present a case of a 70-yr-old man with an asymptomatic left deep lobe parotid mass for which CT-guided FNAB was performed.
  • The subsequent parotidectomy specimen revealed an encapsulated cystic PA with mixed appendageal differentiation including areas of squamous, mucinous, sebaceous, and oncocytic metaplasia.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754364.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Rizvi SA, Gupta Y, Gupta M: Surgical treatment and histopathological analysis of proptosis. Nepal J Ophthalmol; 2010 Jan-Jun;2(1):31-4
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  • INTRODUCTION: Inflammations and tumors of the orbit and para-orbital regions may present as proptosis.
  • According to location and type of tumour, different surgical options like anterior orbitotomy, lateral orbitotomy and medial orbitotomy were considered.
  • Primary orbital tumors were encountered in 15 cases (60%) and para-orbital in 10 (40%).
  • Of 15 primary orbital tumors, 7 (46.66%) were excised by lateral orbitotomy, another 7 (46.66%) were approached via anterior orbitotomy, whereas 1 (6.67%) was removed by medial orbitotomy.
  • Pediatric orbital tumors were quite common {7 (46.66%)}.
  • The most common benign adult tumor found in our study was pleomorphic adenoma of the lacrimal gland {3 (20%)}.
  • Proptosis due to primary orbital tumors is more common than para-orbital tumors.

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  • (PMID = 21141324.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nepal
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41. Iwai H, Yamashita T: Local excision procedure for Warthin's tumor of the parotid gland. Otolaryngol Head Neck Surg; 2005 Apr;132(4):577-80
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  • [Title] Local excision procedure for Warthin's tumor of the parotid gland.
  • The aim of this work is to establish a local excision procedure (LEP) and indications of this procedure for Warthin's tumor.
  • Seventy-three patients (82 sides) with Warthin's tumor were studied.
  • For Warthin's tumor estimated to be below the I-S line (Group A), LEP was used, involving resection of the tumor after locating and dissecting the marginal mandibular and colli branches.
  • For tumors not meeting these criteria (Group B), partial superficial parotidectomy was performed.
  • Conversely, no significant difference in tumor size or incidence of postoperative facial paresis was identified between the 2 groups.
  • In conclusion, LEP is useful for Warthin's tumor below the I-S line.
  • This procedure seems applicable not only to Warthin's tumors, but also to other benign parotid tumors in the surgical field below the I-S line, such as pleomorphic adenoma and lymphoepithelial cyst.
  • [MeSH-major] Adenolymphoma / surgery. Microsurgery / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 15806048.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Kawabata A, Okano K, Uchida K, Yamaguchi R, Hayashi T, Tateyama S: Co-localization of chondromodulin-I (ChM-I) and bone morphogenetic protein-6 (BMP-6) in myoepithelial cells of canine mammary tumors. J Vet Med Sci; 2005 Nov;67(11):1097-102
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  • [Title] Co-localization of chondromodulin-I (ChM-I) and bone morphogenetic protein-6 (BMP-6) in myoepithelial cells of canine mammary tumors.
  • To compare the roles of chondromodulin-I (ChM-I) and bone morphogenetic protein-6 (BMP-6) in ectopic mesenchymal tissue formation in canine mammary gland tumors, 33 tumors and 2 normal mammary glands were examined.
  • Immunohistochemical analysis revealed co-expression of ChM-I and BMP-6 in canine mammary tumors.
  • In mixed tumors, newly formed woven bone with ossified cartilage matrix was observed in 4/9 cases.
  • The immunoreactivity to ChM-I and BMP-6 of the interstitial myoepithelial cells in the myxomatous stroma varied in each focus of mixed tumors.
  • Similar findings were found in complex adenomas.
  • In simple adenomas, hyperplasic myoepithelial cells within the basement membrane showed moderate immunoreactivity to both markers.
  • Western blot analysis detected a 25 kDa band of ChM-I in fresh tissue samples from three mixed tumors.
  • Our results support the hypothesis that proliferating myoepithelial cells with ChM-I and BMP-6 expression play important roles in mesenchymal metaplasia in canine mammary tumors.

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  • (PMID = 16327219.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bone Morphogenetic Protein 6; 0 / Bone Morphogenetic Proteins; 0 / Proteins
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43. de Ru JA, van Leeuwen MS, van Benthem PP, Velthuis BK, Sie-Go DM, Hordijk GJ: Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors? J Oral Maxillofac Surg; 2007 May;65(5):945-52
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  • [Title] Do magnetic resonance imaging and ultrasound add anything to the preoperative workup of parotid gland tumors?
  • PURPOSE: To assess the additional value of magnetic resonance imaging (MRI) and ultrasound (US) to physical examination (PE) and fine needle aspiration cytology (FNAC) in the preoperative determination of the location and histology of parotid gland tumors.
  • PATIENTS AND METHODS: Prospectively, 99 patients with 77 benign and 22 malignant lesions were included; 82 underwent parotidectomy.
  • On PE, the location of the tumor was predicted.
  • Furthermore, the location of the tumor in relation to the facial nerve was predicted.
  • RESULTS: Of the MRI characteristics, incomplete demarcation from normal parotid gland tissue showed the highest positive predictive value (PPV) for malignancy of 0.48.
  • Cytology correctly predicted the benign or malignant nature of the tumor in all cases.
  • CONCLUSION: FNAC is the only accurate investigation for classifying a parotid gland tumor as benign or malignant.
  • Palpation and MRI are superior to US in predicting tumor location.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Biopsy, Fine-Needle / methods. Lymphoma, B-Cell, Marginal Zone / pathology. Parotid Diseases / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve / anatomy & histology. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Staging / methods. Parotid Gland / anatomy & histology. Parotid Gland / innervation. Physical Examination. Reference Standards. Single-Blind Method

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  • (PMID = 17448846.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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44. Precetti FA, Prieto Mde C, Pietrantonio A, González B: [Mixed carcinoid-adenocarcinoma in transverse colon]. Acta Gastroenterol Latinoam; 2010 Dec;40(4):357-60
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  • [Title] [Mixed carcinoid-adenocarcinoma in transverse colon].
  • [Transliterated title] Tumor mixto carcinoide-adenocarcinoma de colon transverso.
  • The following case is a 69-year-old woman with a presumptive diagnosis of adenocarcinoma in transverse colon, which was diagnosed by pathology as a mixed carcinoid-adenocarcinoma tumor after surgery.
  • We have found very few cases published of this type of tumor in the colon (around 20) but not cases in the transverse colon.
  • We point out with particular consideration that, due to the lack of information related to the functional behaviour and clinical characteristics of these mixed tumors, more studies, analysis, follow-up and descriptions are necessary to perform future diagnosis and therapeutic procedures.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoid Tumor / diagnosis. Colon, Transverse / pathology. Colonic Neoplasms / diagnosis. Mixed Tumor, Malignant / diagnosis

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  • (PMID = 21381410.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Argentina
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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45. Tweedie DJ, Jacob A: Surgery of the parotid gland: evolution of techniques, nomenclature and a revised classification system. Clin Otolaryngol; 2009 Aug;34(4):303-8
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  • [Title] Surgery of the parotid gland: evolution of techniques, nomenclature and a revised classification system.
  • [MeSH-minor] Adenoma, Pleomorphic / classification. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Dissection / classification. Dissection / trends. Facial Nerve Injuries / prevention & control. Facial Paralysis / prevention & control. Forecasting. Humans. International Classification of Diseases. Parotid Gland / pathology. Parotid Gland / surgery. Postoperative Complications / prevention & control

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  • (PMID = 19673976.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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46. Jakubowski M, Hunt JL: BRAF mutational analysis in papillary carcinomas with mixed follicular and papillary growth patterns. Am J Surg Pathol; 2009 Nov;33(11):1590-3
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  • [Title] BRAF mutational analysis in papillary carcinomas with mixed follicular and papillary growth patterns.
  • Tumors with mixed patterns of growth, including distinctive area of follicular and papillary growth, have not been well studied for the presence of the BRAF gene mutation.
  • The tumor stage was obtained, along with demographic information.
  • Seventy percent of the tumors were positive for the BRAF mutation.
  • These molecular data support the common diagnostic decision that a tumor with any amount of conventional papillary growth should be designated as a conventional papillary carcinoma, regardless of the presence of follicular growth pattern areas.

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  • (PMID = 19738460.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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47. Kano H, Kondziolka D, Niranjan A, Flickinger JC, Lunsford LD: Stereotactic radiosurgery for pilocytic astrocytomas part 1: outcomes in adult patients. J Neurooncol; 2009 Nov;95(2):211-218
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  • Localized solid tumor progression was seen in two patients.
  • Cyst progression was noted in three of nine patients with cystic tumors and mixed solid and cyst progression was noted in two with cystic tumors.
  • The progression free survival after SRS (including tumor growth and cyst enlargement) for the entire series was 83.9%, 31.5% and 31.5% at 1, 3 and 5 years, respectively.
  • Despite their purported benign nature, pilocytic astrocytomas in adult patients often do not behave benignly.
  • Delayed cyst progression contributes to late loss of tumor control.

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  • (PMID = 19468691.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Gütgemann I, Lehman NL, Jackson PK, Longacre TA: Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Mod Pathol; 2008 Apr;21(4):445-54
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  • Clear cell carcinoma is a clinically and pathologically distinct entity among surface epithelial ovarian neoplasms, recognized for its resistance to standard platinum-based chemotherapy at advanced stage disease and poor prognosis.
  • We investigated Emi1 protein expression in ovarian neoplasms using a tissue microarray constructed from 339 primary ovarian surface epithelial (serous, endometrioid, clear cell, and mucinous) and peritoneal (serous) neoplasms, stromal and mesenchymal tumors, germ cell tumors, and normal ovarian tissue.
  • Significant overexpression of Emi1 protein was present in 82% (27/33) clear cell carcinoma, including one borderline tumor in a diffuse, granular cytoplasmic and perinuclear staining pattern, independent of patient age, presence of ovarian and/or pelvic endometriosis, and FIGO stage.
  • Emi1 protein expression was present in mixed endometrioid/clear cell tumors but absent in tumors with mixed serous/clear cell histology.

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  • (PMID = 18204430.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin E; 0 / F-Box Proteins; 0 / FBXO5 protein, human; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; EC 6.3.2.19 / Anaphase-Promoting Complex-Cyclosome; EC 6.3.2.19 / Ubiquitin-Protein Ligase Complexes
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49. Peersman B, Vanhoenacker FM, Heyman S, Van Herendael B, Stam M, Brys P, Verstraete KL, Samson I, Sybers J, Van Dyck P, Parizel PM, De Schepper AM: Ewing's sarcoma: imaging features. JBR-BTR; 2007 Sep-Oct;90(5):368-76
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  • MATERIALS AND METHODS: Sixty-four patients with a histopathologically and/or genetically proven diagnosis of ES were analyzed for clinical parameters (age, gender and location), radiographic and CT appearance (distribution, matrix, margins, periosteal reaction, articular extension, cortical reaction and the presence of a pathologic fracture).
  • Most tumors were mixed lytic-sclerotic (75%), and purely lytic in 25%.
  • ES is mostly mixed sclerotic-lytic.
  • The most characteristic finding on MRI is the presence of a large soft tissue mass.

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  • (PMID = 18085191.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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50. Ghosh A, Arundhati, Asthana AK: Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report. Acta Cytol; 2008 Nov-Dec;52(6):733-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report.
  • BACKGROUND: Metastasizing pleomorphic adenoma (MPA) is a rare, incompletely understood enigmatic entity having the histologic appearance of benign pleomorphic adenoma and clinically malignant behavior.
  • We report a case of MPA of the parotid gland that metastasized to the scapular region 6 years after the appearance of the primary lesion in the left parotid gland.
  • The patient had a prior history of surgical removal of recurrent pleomorphic adenoma of the left parotid salivary gland.
  • Fine needle aspiration cytology (FNAC) smears of both sites demonstrated the 3 components (i.e., stromal, mesenchymal and epithelial) of benign pleomorphic adenoma with benign features.
  • CONCLUSION: The appearance of a mass lesion or subcutaneous nodule with a prior history of pleomorphic adenoma should alert for the possibilities of metastatic carcinoma, metastatic carcinosarcoma and MPA.
  • With well-established cytomorphology of pleomorphic adenoma, FNAC remains the investigation method of choice for metastatic workup of a case of locally recurrent pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology. Scapula

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  • (PMID = 19068682.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Huang X, Sun W, Liu X, Liu W, Guan Z, Xu Y, Zheng Y: Endoscope-assisted partial-superficial parotidectomy through a concealed postauricular skin incision. Surg Endosc; 2009 Jul;23(7):1614-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Endoscope-assisted partial-superficial parotidectomy through a concealed postauricular skin incision was performed for 18 cases of benign tumor located in the superficial lobe of the parotid gland.
  • CONCLUSIONS: Endoscope-assisted partial-superficial parotidectomy is a feasible method for treatment of benign tumors located in the superficial lobe of the parotid gland.
  • [MeSH-major] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Endoscopy / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 19343432.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
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52. El Fakiri MM, Aderdour L, Nouri H, Hassani R, Maliki O, Raji A: [Pleomorphic adenoma of the nasal septum]. Rev Stomatol Chir Maxillofac; 2010 Jun;111(3):162-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic adenoma of the nasal septum].
  • INTRODUCTION: The pleomorphic adenoma is the most common benign neoplasm of primary salivary glands.
  • We report a case of pleomorphic adenoma of the nasal septum.
  • A facial CT-scan showed a heterogeneous tumor of the nasal septum obstructing the left nasal vestibule.
  • The biopsy analysis proved the histological characteristics of a pleomorphic adenoma, and was further confirmed by immunohistochemical study.
  • DISCUSSION: The treatment of nasal pleomorphic adenomas must take into account lesion localization, esthetic complications, and evolutionary potential of the lesions.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Nasal Septum / pathology. Nose Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20416914.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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53. Etit D, Tan A, Bayol U, Altinel D, Cumurcu S, Cukurova I: Oncocytic carcinoma ex pleomorphic adenoma. Head Neck Pathol; 2010 Mar;4(1):49-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic carcinoma ex pleomorphic adenoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Combined Modality Therapy. Disease-Free Survival. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 20237989.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2825533
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54. Gahine R, Sudarshan V, Hussain N, Krishnani C: Pleomorphic adenoma: A diagnostic pitfall in the diagnosis of salivary gland lesions on FNAC: Case reports with review of the literature. Cytojournal; 2010;7:17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma: A diagnostic pitfall in the diagnosis of salivary gland lesions on FNAC: Case reports with review of the literature.
  • Fine needle aspiration cytology (FNAC) is commonly being used with increasing frequency for the pre-operative evaluation of salivary gland lesions.
  • The most frequent problems involve variations in the expected cytology of pleomorphic adenoma (PA).
  • Salivary gland FNACs performed at Pt.
  • As PA is the most common salivary gland neoplasm, it should always be considered and ruled out as the first differential in the diagnosis of salivary gland FNACs.
  • To document the same, we advocate liberal use of repeat aspirations with multiple sampling performed from different parts of the tumor.

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  • (PMID = 20976206.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2955342
  • [Keywords] NOTNLM ; FNA salivary gland / pitfalls of diagnosis / pleomorphic adenoma / variability of tumor morphology
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55. Wezensky SJ, Hanks TS, Wilkison MJ, Ammons MC, Siemsen DW, Gauss KA: Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex. Gene; 2010 Feb 15;452(1):22-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pleomorphic adenoma gene (PLAG) family of transcription factors regulates a wide range of physiological processes, including cell proliferation, tissue-specific gene regulation, and embryonic development, although little is known regarding the mechanisms that regulate PLAG protein activity.
  • We show that PC2 cooperates with PLAGL2 and PU.1 to enhance the activity of a known PLAGL2 target promoter (NCF2).

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  • [Copyright] Published by Elsevier B.V.
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  • (PMID = 20025940.001).
  • [ISSN] 1879-0038
  • [Journal-full-title] Gene
  • [ISO-abbreviation] Gene
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / RR-016455; United States / NCRR NIH HHS / RR / P20 RR16455-08; United States / NCRR NIH HHS / RR / RR-020185; United States / NCRR NIH HHS / RR / P20 RR024237-026650; United States / NCRR NIH HHS / RR / RR-024237; United States / NCRR NIH HHS / RR / RR024237-026650; United States / NCRR NIH HHS / RR / P20 RR024237; United States / NCRR NIH HHS / RR / P20 RR016455; United States / NCRR NIH HHS / RR / P20 RR020185
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / MED15 protein, human; 0 / Mediator Complex; 0 / Multiprotein Complexes; 0 / PLAGL2 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA-Binding Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Necrosis Factor-alpha; 0 / proto-oncogene protein Spi-1; 67763-97-7 / Insulin-Like Growth Factor II; EC 1.6.3.1 / NADPH Oxidase; EC 1.6.3.1 / NCF2 protein, human
  • [Other-IDs] NLM/ NIHMS166082; NLM/ PMC2815083
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56. Varshavskiĭ AI: [Clinics, diagnostics and treatment of parotid salivary gland adenomas]. Stomatologiia (Mosk); 2010;89(3):41-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinics, diagnostics and treatment of parotid salivary gland adenomas].
  • Clinical data of 252 patients with parotid gland adenomas (PGA) were produced.
  • Pleomorphic adenoma (PA) was found in 81.3% of PGA cases, adenolymphoma (Warthin's tumor) - in 13%, canalicular adenoma - in 2.8%, other adenomas - in 2.9% of observations.
  • 2 cases of myoepithelioma and cystadenoma of parotid gland were described.
  • The following operations were performed: extracapsular tumorectomy - in 13 patients, adenomectomy with limited gland resection - in 152 patients, subtotal gland resection with nervus facialis separation - in 62 patients, parotidectomy with nervus facialis preservation - in 25 patients.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Parotid Neoplasms / diagnosis. Parotid Neoplasms / surgery

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  • (PMID = 20559235.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii︠a︡
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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57. Tanno T, Tanaka Y, Sugiura T, Akiyoshi H, Takenaka S, Kuwamura M, Yamate J, Ohashi F, Kubo K, Tsuyama S: Expression patterns of the slit subfamily mRNA in canine malignant mammary tumors. J Vet Med Sci; 2006 Nov;68(11):1173-7
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  • [Title] Expression patterns of the slit subfamily mRNA in canine malignant mammary tumors.
  • In humans, slit2 protein attracts endothelial cells and promotes tube formation in the tumor angiogenic mechanism.
  • In this study, we cloned a part of the canine slit subfamily and examined the expression of slit subfamily mRNAs in 3 normal canine mammary glands and 11 mammary tumor samples by RT-PCR.
  • The mRNAs were expressed at low levels in the normal mammary gland.
  • The expression levels of slit1 mRNA were low in both the normal and tumor tissues.
  • In contrast, the expression of slit2 mRNA increased in most of the malignant mammary tumors, and an increase in slit3 mRNA expression was observed in 2 of the malignant mixed tumors.
  • These results suggest that the expression of slit2 plays an important role in tumor angiogenesis in canine mammary gland tumors and that slit2 can be a putative marker for malignancy diagnosis of these tumors.

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  • (PMID = 17146174.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Glycoproteins; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / slit protein, vertebrate
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58. Yerli H, Aydin E, Coskun M, Geyik E, Ozluoglu LN, Haberal N, Kaskati T: Dynamic multislice computed tomography findings for parotid gland tumors. J Comput Assist Tomogr; 2007 Mar-Apr;31(2):309-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dynamic multislice computed tomography findings for parotid gland tumors.
  • OBJECTIVE: Our aim was to research the enhancement features of parotid gland masses in detail and characterize if the masses were Warthin tumors, adenomas, or malignant tumors.
  • METHODS: The prospective study included 25 parotid tumors in 21 patients.
  • A full-neck CT examination was done at 30 seconds after completion of contrast injection, and then tumor-level images were obtained at 90 seconds and at 5 and 25 minutes.
  • Computed tomography number (lesion density in Hounsfield units) was determined at each phase, and differences within and among tumor groups were statistically analyzed.
  • RESULTS: There were 11 Warthin tumors, 8 pleomorphic adenomas, 5 malignant tumors, and 1 basal cell adenoma.
  • Ten Warthin tumors showed rapid contrast enhancement at 30 seconds and rapid reduction of enhancement from the first to the fourth phase.
  • The basal cell adenoma showed also a peak enhancement at 30 seconds.
  • Seven pleomorphic adenomas showed increased enhancement through the first 3 phases.
  • Four malignant tumors showed peak enhancement at 90 seconds.
  • Statistically significant differences within and among tumor groups were determined.
  • CONCLUSIONS: The data suggest that peak tumor enhancement at 30 and 90 seconds, respectively, might identify Warthin and malignant tumors.
  • Increased enhancement through all phases might be an indicator for diagnosing pleomorphic adenomas.
  • [MeSH-major] Adenolymphoma / diagnosis. Adenoma / diagnosis. Carcinoma / diagnosis. Lymphoma / diagnosis. Parotid Gland / radiography. Parotid Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 17414771.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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59. Siddaraju N, Murugan P, Basu D, Verma SK: Preoperative cytodiagnosis of cystic pleomorphic adenoma with squamous metaplasia and cholesterol crystals: a case report. Acta Cytol; 2009 Jan-Feb;53(1):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative cytodiagnosis of cystic pleomorphic adenoma with squamous metaplasia and cholesterol crystals: a case report.
  • BACKGROUND: Pleomorphic adenoma with extensive squamous metaplasia and cystic change may cause diagnostic confusion both in cytology and histopathology, which stresses the need for a guarded approach while interpreting such lesions.
  • Routine fine needle aspiration (FNA) yielded mucoid fluid, mixed with whitish particles.
  • The cystic nature of the swelling caused some degree of diagnostic dilemma; however, ultimately, a cytologic diagnosis of "pleomorphic adenoma with squamous metaplasia and cystic change" was offered, which was confirmed by subsequent histopathologic examination.
  • CONCLUSION: Our case emphasizes the need for a cautious and systematic approach in the cytologic and histopathologic interpretation of cystic pleomorphic adenoma with metaplastic epithelial changes.
  • Cholesterol crystals found in the aspirate material of our case is a rare finding in pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Cholesterol / analysis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 19248563.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 97C5T2UQ7J / Cholesterol
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60. Oztürk E, Sağlam O, Sönmez G, Cüce F, Haholu A: CT and MRI of an unusual intranasal mass: pleomorphic adenoma. Diagn Interv Radiol; 2008 Dec;14(4):186-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CT and MRI of an unusual intranasal mass: pleomorphic adenoma.
  • A rare case of pleomorphic adenoma arising from the nasal septum is presented.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) of a 65- year-old woman who presented with right sided nasal obstruction, nasal discharge and epistaxis revealed a well-defined lobular mass occupying the right nasal cavity.
  • Histopathologic examination revealed a pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Magnetic Resonance Imaging / methods. Nasal Septum / pathology. Nose Neoplasms / diagnosis. Tomography, X-Ray Computed / methods

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  • (PMID = 19061162.001).
  • [ISSN] 1305-3612
  • [Journal-full-title] Diagnostic and interventional radiology (Ankara, Turkey)
  • [ISO-abbreviation] Diagn Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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61. Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, Van de Ven WJ, Shivdasani RA: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab; 2007 Nov;6(5):406-13
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  • Here we report that the transcription factor pleomorphic adenoma gene-like 2 (PlagL2) is essential for this aspect of dietary lipid metabolism.

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  • (PMID = 17983586.001).
  • [ISSN] 1550-4131
  • [Journal-full-title] Cell metabolism
  • [ISO-abbreviation] Cell Metab.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK48873; United States / NIDDK NIH HHS / DK / R01 DK56626; United States / NIDDK NIH HHS / DK / R01 DK61139
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chylomicrons; 0 / DNA-Binding Proteins; 0 / Dietary Fats; 0 / Plagl2 protein, mouse; 0 / RNA-Binding Proteins; 0 / Transcription Factors
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62. Kinkor Z, Hes O: [Pleomorphic epithelioid/clear cell malignant tumor of the uterus exhibiting both myoid and melanocytic differentiation--leiomyosarcoma or PEComa? A case report and a review of the literature]. Cesk Patol; 2007 Jul;43(3):103-8
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  • [Title] [Pleomorphic epithelioid/clear cell malignant tumor of the uterus exhibiting both myoid and melanocytic differentiation--leiomyosarcoma or PEComa? A case report and a review of the literature].
  • [Transliterated title] Pleomorfni epiteloidni a svetlobunecný maligní tumor delohy s myoidní a melanocytární diferenciací--leiomyosarkom nebo PECom? Kazuistika a prehled literatury.
  • Microscopically, the tumor displayed solid mosaic pattern and consisted of large epithelioid cells with ample eosinophilic, finely granular cytoplasm ongoing apparent clear cell change elsewhere.
  • No obvious stigmata of tuberous sclerosis were found and a five months follow-up after chemotherapy indicated no progression of disease.
  • With some uncertainty the tumor was finally rendered as pleomorphic leiomyosarcoma with peculiar melanocytic differentiation.
  • Expressed are both difficulty in explaining the histogenesis and ambiguity of the existing terminology of the uterine tumors with mixed myoid and melanocytic phenotype.


63. Gao P, Zhou GY, Song XR, Hou JX, Zhang CJ, Ma C: [The relationship of abnormal expression of cell glucoprotein with recurrence of pleomorphic adenoma in salivary gland]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2005 Apr;23(2):164-6
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  • [Title] [The relationship of abnormal expression of cell glucoprotein with recurrence of pleomorphic adenoma in salivary gland].
  • OBJECTIVE: To study the relationship of expression of mucin 1 and E-cadherin with recurrence of pleomorphic adenoma in salivary gland, and to investigate the signal to predict the recurrence potential of the tumor.
  • METHODS: ; The capsule of tumor was observed by microscope.
  • The expression of mucin 1 and E-cadherin in 33 cases of primary adenoma, 12 cases of recurrent pleomorphic adenomas and 7 cases of malignant pleomorphic adenomas were detected by immunohistochemistry.
  • RESULTS: There was no significant difference about the status of capsule and the positive rate of mucin 1 expression between primary and recurrent pleomorphic adenoma (P > 0.05).
  • The abnormal distribution of mucin 1 expression was observed in recurrent pleomorphic adenoma (6/8), which was characterized by the positive staining of the whole cytomembrane.
  • On the other hand, positive staining of the primary pleomorphic adenoma was observed on the top of the membrane (19/21).
  • The staining pattern in malignant pleomorphic adenoma was similar with the recurrent ones except higher ratio of positive expression.
  • No significant different was observed among the three kind of tumors on the expression rate of E-cadherin (P > 0.05).
  • CONCLUSION: The status of capsule didn't have much actual usage in predicting the recurrence of pleomorphic adenoma.
  • There was no significant relationship between the expression of E-cd and the recurrence of the tumor.
  • The abnormal distribution of mucin 1 expression contributes to the invasiveness of the tumor and can be used as the predictive signal for recurrence of pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / physiopathology. Cadherins / metabolism. Mucin-1 / metabolism. Salivary Gland Neoplasms / physiopathology


64. Acikalin MF, Pasaoglu O, Cakli H, Gürbüz K, Canaz F: Malignant myoepithelioma of the palate: a case report with review of the clinicopathological characteristics. Yonsei Med J; 2009 Dec 31;50(6):848-51
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  • A malignant myoepithelioma is one of the rarest salivary gland neoplasms which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma.
  • The parotid gland is the most common primary site and the palate the most common intra-oral site of occurrence.
  • Herein is present a case of a malignant myoepithelioma arising in the hard palate of a 79-year-old woman.
  • The patient underwent a wide local tumor resection.
  • Examination of the resection specimen showed the characteristic histopathological and immunohistochemical features of a malignant myoepithelioma.

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  • [Cites] Am J Surg Pathol. 2000 Jun;24(6):761-74 [10843278.001]
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  • (PMID = 20046429.001).
  • [ISSN] 1976-2437
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2796415
  • [Keywords] NOTNLM ; Malignant myoepithelioma / palate
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65. Wong MH, Dobbins TA, Tseung J, Tran N, Lee CS, O'Brien CJ, Clark J, Rose BR: Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland. J Clin Pathol; 2009 Sep;62(9):789-93
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  • [Title] Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland.
  • AIMS: Pleomorphic adenomas of the salivary gland have gender and age distributions suggesting that oestrogen has a causal role.
  • However, oestrogen receptor (ER)alpha is expressed at low levels in normal salivary gland tissues and data from salivary gland tumours are conflicting.
  • There is preliminary evidence that the recently described ERbeta may be the major ER in salivary gland tissue.
  • The aim of this study was to determine the nature and extent of ERbeta expression in pleomorphic adenomas of the salivary gland.
  • METHODS: Pleomorphic adenomas and normal tissues of the parotid gland from 49 patients were tested for ERalpha and ERbeta expression by semiquantitative immunohistochemistry.
  • RESULTS: ERalpha and ERbeta expression was localised mainly to the nuclei of ductal cells in normal tissues and the epithelial components in pleomorphic adenomas.
  • Within each tissue and receptor type there were no associations between ER positivity and patient age or gender.
  • ERbeta was expressed in almost twice as many normal tissues and pleomorphic adenomas as ERalpha.
  • Expression of ERbeta was also significantly higher in tumour compared with normal tissues.
  • CONCLUSIONS: This is thought to be the first study of ERbeta in pleomorphic adenomas of the salivary gland.
  • Findings support ERbeta as the major ER in salivary glands, and provide evidence that ERbeta may have a role in the development of pleomorphic adenomas of the salivary gland.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Estrogen Receptor beta / metabolism. Parotid Neoplasms / metabolism
  • [MeSH-minor] Adult. Age Factors. Estrogen Receptor alpha / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / metabolism. Parotid Gland / metabolism. Sex Factors

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  • (PMID = 19734474.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Neoplasm Proteins
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66. Schulhof Z, Anastassov GE, Lumerman H, Mashadian D: Giant benign chondroid syringoma of the cheek: case report and review of the literature. J Oral Maxillofac Surg; 2007 Sep;65(9):1836-9
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  • [Title] Giant benign chondroid syringoma of the cheek: case report and review of the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Facial Neoplasms / pathology

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  • (PMID = 17719408.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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67. Logasundaram R, Amarawickrama H, Premachandra D, Hellquist H: Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1563-6
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  • [Title] Intracapsular (in situ) carcinoma ex pleomorphic adenoma with unusual clinical and histological features.
  • Carcinoma ex pleomorphic adenoma poses a challenge to diagnosis and treatment.
  • Herein we describe an extremely unusual case, which presented initially as an intracapsular carcinoma ex pleomorphic adenoma in the right parotid gland.
  • The first recurrence, after an interval of 8 years, showed only recurrence of the benign component.
  • No ductal carcinoma as seen in the initial intracapsular carcinoma ex pleomorphic adenoma was identified.
  • This case report elucidates the atypical clinical behaviour and interesting histological features encountered within this group of salivary neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma in Situ / pathology. Myoepithelioma / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1986;409(1):93-103 [2422810.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1993;423(5):389-96 [8116228.001]
  • [Cites] Anticancer Res. 1997 Jul-Aug;17(4A):2671-5 [9252699.001]
  • [Cites] Mod Pathol. 1996 Jun;9(6):652-7 [8782203.001]
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  • (PMID = 18288478.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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68. Tilakaratne WM, Jayasooriya PR, Tennakoon TM, Saku T: Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Jul;108(1):90-8
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  • [Title] Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases.
  • OBJECTIVE: The aim of this retrospective study was to evaluate the clinicopathologic data to determine the distribution of epithelial salivary tumors, especially minor salivary tumors, in Sri Lanka.
  • MATERIALS AND METHODS: A total of 713 salivary tumors diagnosed at the Department of Oral Pathology, during the period from 1990 to 2007 were reviewed.
  • RESULTS: Out of the 713 epithelial salivary tumors, 356 (49.9%) were classified as benign and 357 (50.1%) as malignant, indicating a benign-to-malignant ratio of 1:1.
  • The majority of both benign (29%) and malignant (39%) tumors occurred in the minor salivary glands.
  • Malignant tumors were slightly more common in minor salivary glands, indicating a benign-to-malignant ratio of 1:0.75.
  • Among the minor salivary sites, palate was the most frequent location, accounting for 51% of the tumors (246 out of 486).
  • The tumors affected adult patients more commonly, and a slight female predominance (1:1.15) was also evident.
  • Pleomorphic adenoma was the most frequent tumor, representing 38% of all tumors (274 out of 713), followed by mucoepidermoid carcinoma 21.6% (154 out of 713) and adenoid cystic carcinoma 13.5% (96 out of 713).
  • The commonest benign and malignant tumors were pleomorphic adenoma and mucoepidermoid carcinoma in both major and minor salivary glands.
  • CONCLUSION: According to the findings of this study, equal frequencies of benign and malignant tumors indicate higher occurrences of malignancies, especially in the minor salivary glands, in the Sri Lankan population.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / epidemiology. Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenolymphoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Female. Humans. Male. Middle Aged. Palatal Neoplasms / epidemiology. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Sex Factors. Sri Lanka / epidemiology

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  • (PMID = 19403317.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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69. Clark S, Greenwood M, Fullarton M, Russell JS: An unusual case of floor of mouth swelling: case report, differential diagnosis and a review of the literature. Dent Update; 2005 Dec;32(10):617-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Diagnosis, Differential. Female. Humans. Middle Aged. Mouth Floor / pathology. Ranula / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 16379439.001).
  • [ISSN] 0305-5000
  • [Journal-full-title] Dental update
  • [ISO-abbreviation] Dent Update
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 11
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70. Ebbing J, Blind C, Stein H, Miller K, Loddenkemper C: Metastasizing pleomorphic adenoma presenting as an asymptomatic kidney tumor twenty-nine years after parotidectomy - urological viewpoint and overview of the literature to date. Rare Tumors; 2009;1(2):e54
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  • [Title] Metastasizing pleomorphic adenoma presenting as an asymptomatic kidney tumor twenty-nine years after parotidectomy - urological viewpoint and overview of the literature to date.
  • Pleomorphic adenomas (benign mixed tumors) are the most common tumors of glandular origin in the head and neck and are one of the few benign neoplasms that can undergo malignant transformation.(1) Mixed tumors that are seemingly benign at the microscopic level but metastasize have been termed metastasizing mixed tumors (MZMTs).
  • The entity of metastasizing benign mixed tumors has been reported since the early 1940s, with up to approximately 50 cases described in the literature to date.
  • Despite their bland morphologic appearance, MZMTs have been associated with an overall mortality rate of about 20-40%.
  • We report the case of a MZMT of the kidney almost 30 years after lateral parotidectomy owing to the same tumor entity.
  • For benign mixed tumors, we are unaware of more than two other cases of metastasis to the kidney that have been published, whereas metastases to the bone, lung, and lymph nodes are more common.
  • Parotidectomy is widely accepted as the first choice of treatment,(13) but once metastases have occurred the therapeutic strategy is uncertain with surgery being the only curative option in cases with resectable disease.
  • This case report provides information about the rare event of metastatic disease to the kidney and points out therapeutic strategies.
  • However, in view of the general lack of adequate information in the literature, the best therapy for systemic disease still remains unresolved.

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  • (PMID = 21139933.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994456
  • [Keywords] NOTNLM ; carcinoma ex-mixed tumor / kidney metastasis / kidney tumor. / metastasizing mixed tumor / metastasizing pleomorphic adenoma
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71. Paleri V, Robinson M, Bradley P: Polymorphous low-grade adenocarcinoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg; 2008 Apr;16(2):163-9
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  • An increasing number of reports in the pathology literature since then have identified this as the second or the third most common minor salivary gland malignancy.
  • The natural history of polymorphous low-grade adenocarcinoma is distinct from other malignant salivary tumours.
  • The present review will identify the diagnostic difficulties, the treatment options and the treatment outcome of this tumour.
  • RECENT FINDINGS: Polymorphous low-grade adenocarcinoma is a slow-growing tumour that is locally invasive.
  • The most common presentation is that of a lump in the oral cavity, usually on the palate.
  • The morphological features can resemble pleomorphic adenoma and adenoid cystic carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18327037.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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72. Pelaz AC, Llorente Pendás JL, Bueno GC, Suárez Nieto C: Simultaneous pleomorphic adenomas of the hard palate and parapharyngeal space. J Craniofac Surg; 2009 Jul;20(4):1298-9
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  • [Title] Simultaneous pleomorphic adenomas of the hard palate and parapharyngeal space.
  • We report a very unusual presentation of simultaneous pleomorphic adenomas of 2 different locations, hard palate and parapharyngeal space.
  • Patient age of presentation is rare because these tumors are seen in younger patients.
  • We treated a 70-year-old woman with these 2 tumors, resecting both lesions with intraoral and cervical approaches.
  • Pleomorphic adenomas are frequent lesions, but in the literature reviewed, we have not found articles reporting 2 simultaneous pleomorphic adenomas of these locations.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Neoplasms, Multiple Primary / surgery. Palatal Neoplasms / surgery. Pharyngeal Neoplasms / surgery

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  • (PMID = 19625855.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Koyuncu M, Karagöz F, Kiliaçarslan H: Pleomorphic adenoma of the external auditory canal. Eur Arch Otorhinolaryngol; 2005 Dec;262(12):969-71
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  • [Title] Pleomorphic adenoma of the external auditory canal.
  • Pleomorphic adenoma of the external auditory canal is a rare disease.
  • The objective of this study is to familiarize the clinician with the clinical presentation and treatment of this disease.
  • We report the case of a 58-year-old woman.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ear Neoplasms / diagnosis. Ear, External / pathology

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  • [Cites] Laryngoscope. 1977 Oct;87(10 Pt 1):1601-12 [198620.001]
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  • (PMID = 15968569.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins; 68238-35-7 / Keratins
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74. El-Hadi T, Oujilal A, Boulaich M, Sqalli L, Kzadri M: Plemorphic adenoma of the infratemporal space: a new case report. Int J Otolaryngol; 2009;2009:529350
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  • [Title] Plemorphic adenoma of the infratemporal space: a new case report.
  • Plemorphic adenoma is a frequent benign tumor of the major salivary glands.
  • It could also develop from accessory salivary glands.
  • We are reporting an extremely rare case of pleomorphic adenoma developing from the infratemporal space.
  • Diagnosis, clinical behaviour, and treatment of pleomorphic adenoma of the infra-temporal space are reviewed from the literature.

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  • [Cites] Auris Nasus Larynx. 2003 Dec;30(4):417-20 [14656569.001]
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  • (PMID = 20169128.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2821647
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75. Zhu JP, Hu HT, Xiang R, Yi WH, Liu Z: [FTIR analysis of benign and malignant pleomorphic adenoma tissues]. Guang Pu Xue Yu Guang Pu Fen Xi; 2007 Jul;27(7):1295-8
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  • [Title] [FTIR analysis of benign and malignant pleomorphic adenoma tissues].
  • The FTIR (Fourier transform infrared) spectra of benign pleomorphic adenoma tissues and malignant ones were investigated using the spectrometer GX FTIR Spectroscopy.
  • The results indicated that there were infrared spectra difference between the benign adenoma tissues and the malignant ones in some bands.
  • Compared to the benign adenoma tissues, the contents of nucleic acid relative to the collagen protein and the adipose relative to the protein both increase in malignant ones.
  • [MeSH-major] Adenocarcinoma / chemistry. Adenoma / chemistry. Spectroscopy, Fourier Transform Infrared / methods

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  • (PMID = 17944398.001).
  • [ISSN] 1000-0593
  • [Journal-full-title] Guang pu xue yu guang pu fen xi = Guang pu
  • [ISO-abbreviation] Guang Pu Xue Yu Guang Pu Fen Xi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Lipids; 0 / Nucleic Acids; 0 / Proteins
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76. Virk RS, Hundal H: Bilateral pleomorphic adenoma of the anterior tongue: a case report. Ear Nose Throat J; 2005 Dec;84(12):789-90
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  • [Title] Bilateral pleomorphic adenoma of the anterior tongue: a case report.
  • We report a case of bilateral pleomorphic adenoma of the anterior two-thirds of the tongue in a 38-year-old man.
  • Both tumors were excised via a transoral route.
  • To the best of our knowledge, this is the first reported case of a bilateral pleomorphic adenoma of the anterior tongue.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16408560.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Maruya S, Shirasaki T, Nagaki T, Kakehata S, Kurotaki H, Mizukami H, Shinkawa H: Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications. BMC Cancer; 2009;9:72
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  • [Title] Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications.
  • BACKGROUND: Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis.
  • The purpose of this study was to evaluate the expression of topoIIalpha in various types of salivary gland tumors and its biological significance.
  • METHODS: The protein expression of topoIIalpha was evaluated immunohistochemically in formalin-fixed, paraffin-embedded tissue from 54 salivary gland carcinomas and 20 benign tumors (10 pleomorphic adenomas and 10 Warthin's tumors).
  • The primary salivary gland carcinoma specimens consisted of 17 adenoid cystic carcinomas, 7 adenocarcinomas not otherwise specified, 7 mucoepidermoid carcinomas, 6 salivary duct carcinomas, 3 acinic cell carcinomas, 3 carcinomas ex pleomorphic adenomas, 3 epithelial-myoepithelial carcinomas, 2 carcinosarcomas, 2 lymphoepithelial carcinomas, 2 myoepithelial carcinomas, 1 oncocytic carcinoma, and 1 squamous cell carcinoma.
  • RESULTS: Of the 54 primary salivary gland carcinomas, 38 (70%) showed positive expression (> or = 10%) of topoIIalpha protein, and 16 carcinomas (30%) and all benign tumors were negative (p < 0.001).
  • Expression of topoIIalpha was more frequently observed in salivary duct carcinoma, carcinoma ex pleomorphic adenoma, adenocarcinoma, and adenoid cystic carcinoma, solid type, and it was associated with advanced stage and shortened survival.
  • Furthermore, it may provide useful prognostic information and suggests the potential efficacy of topoIIalpha-targeting therapy in patients with salivary gland carcinoma.
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. DNA Topoisomerases, Type II / biosynthesis. DNA-Binding Proteins / biosynthesis. Salivary Gland Neoplasms / enzymology

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  • [Cites] Head Neck. 2000 Aug;22(5):489-97 [10897109.001]
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  • (PMID = 19250538.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC2654461
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78. Vyrupaev SV: [Treatment of giant tumors of the parotid gland]. Vopr Onkol; 2005;51(1):128-30
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  • [Title] [Treatment of giant tumors of the parotid gland].
  • Since large (<<giant>>) benign mixed tumors of the parotid gland are rare, there is insufficient evidence on the modalities of the facial nerve management.
  • Eight patients, aged 29-65, with tumors of more than 15 cm in diameter were operated on.
  • Tumors were located externally of the gland (5), parapharyngeally (2), or both (1).
  • The regularities between the facial nerve location and site of tumor were investigated, and it is suggested that, in difficult cases, search should start from the temporal area since it offers most access.
  • When tumor of parapharyngeal localization is excised, it is desirable to perform double osteotomy in the mental part of the mandible as well as at the point of entry of the lower of the alveolar nerve, to avoid the latter's being traumatized.
  • [MeSH-major] Parotid Gland / pathology. Salivary Gland Neoplasms / surgery

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  • (PMID = 15909823.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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79. Neves Cde O, Soares AB, Costa AF, de Araujo VC, Furuse C, Juliano PB, Altemani A: CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms. Appl Immunohistochem Mol Morphol; 2010 Mar;18(2):172-8
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  • [Title] CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms.
  • In salivary glands, expression of CD10 has only been used to identify neoplastic myoepithelial cells of pleomorphic adenomas and myoepithelial carcinomas.
  • However, its accuracy in other salivary tumors with myoepithelial component has yet to be analyzed.
  • We examined 72 salivary tumors with myoepithelial differentiation using immunohistochemical technique to detect CD10.
  • In salivary glands, CD10 expression was not detected in myoepithelial cells.
  • In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms.
  • When the different groups of tumors were compared, epithelial-myoepithelial carcinomas (EMEC) showed a stark contrast with the others (83.3% of cases with CD10 expression).
  • Surprisingly, adenoid cystic carcinomas and basal cell adenomas were negative in 100% of the cases.
  • Myoepitheliomas, pleomorphic adenomas, and myoepithelial carcinomas were positive in 27.7%, 30.0%, and 40% of the cases, respectively.
  • In conclusion, salivary neoplastic myoepithelial cells gain CD10 expression in relation to their normal counterparts.
  • However, the gain of this protein is not a sensitive marker for detecting myoepithelial cells in the majority of the tumors, except for EMEC.

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  • (PMID = 19752720.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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80. Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD: Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope; 2006 Dec;116(12):2145-9
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  • Fifteen patients had their initial treatment at our institution, and four patients presented with a recurrent tumor.
  • Five patients had a local recurrence after surgery; of those patients, two had initially presented with recurrent tumors.
  • Local tumors recurred as late as 15 years after the initial surgery.
  • One patient had regional nodal disease 20 years after the initial procedure, and another had lung metastasis.
  • The most common initial diagnoses were polymorphous low-grade adenocarcinoma, adenoid cystic carcinoma, and pleomorphic adenoma.
  • CONCLUSIONS: Polymorphous low-grade adenocarcinoma is an increasingly recognized malignancy that originates predominantly in the minor salivary gland.
  • [MeSH-major] Adenocarcinoma / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Salivary Glands, Minor


81. Bellizzi AM, Mills SE: Collagenous crystalloids in myoepithelial carcinoma: report of a case and review of the literature. Am J Clin Pathol; 2008 Sep;130(3):355-62
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  • [Title] Collagenous crystalloids in myoepithelial carcinoma: report of a case and review of the literature.
  • Since the first report of "tyrosine crystals" in a parotid mixed tumor by Bullock in 1953, authors have described several types of crystalloids in association with mixed tumor and related neoplastic and nonneoplastic entities.
  • We report a myoepithelial carcinoma of minor salivary gland origin containing numerous collagenous crystalloids.
  • In addition, we searched our institution's files for cases of pure myoepithelial tumors.
  • We review the literature on salivary-related crystalloids, and we propose the term oncocyte/cyst-associated crystalloids to encompass the aforementioned third class of crystalloid.
  • Given distinct morphologic and histochemical properties and given relatively limited disease associations, we conclude that in the appropriate clinical context, the identification of these crystalloids can be diagnostically useful.
  • [MeSH-major] Collagen / metabolism. Salivary Gland Neoplasms / pathology

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  • (PMID = 18701407.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
  • [Number-of-references] 31
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82. Kolokythas A, Fernandes RP, Ord R: A non-lip-splitting double mandibular osteotomy technique applied for resection of tumors in the parapharyngeal and pterygomandibular spaces. J Oral Maxillofac Surg; 2007 Mar;65(3):566-9
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  • [Title] A non-lip-splitting double mandibular osteotomy technique applied for resection of tumors in the parapharyngeal and pterygomandibular spaces.
  • [MeSH-minor] Adenoma, Pleomorphic / surgery. Adult. Female. Giant Lymph Node Hyperplasia / surgery. Humans. Lip. Male. Oropharyngeal Neoplasms / surgery. Osteotomy / methods. Skull Base Neoplasms / surgery

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  • (PMID = 17307611.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Pietniczka-Załeska M, Kukwa A: [The parotid gland's tumours in material of Otolaryngology Department Medical Academy in Warsaw in 1990-2006]. Otolaryngol Pol; 2008;62(4):395-9
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  • [Title] [The parotid gland's tumours in material of Otolaryngology Department Medical Academy in Warsaw in 1990-2006].
  • INTRODUCTION: The purpose of this work was the desire for handing over authors' experience in diagnostic and operative procedures in the case of the parotid gland's tumours, presenting gathered material, ways of removing tumours and curing results.
  • MATERIAL AND METHODS: The study is the analysis of 317 patients; 180 (58%) women and 131 (42%) men with parotid gland tumours in patients treated in ENT Department between X. 1989 - XII. 2006.
  • The frequency of incidence of benign tumours was 81%.
  • The most frequent tumours were pleomorphic adenoma and adenolymphoma.
  • Malignant tumours constituted 19% of all parotid gland tumours.
  • (1) There were 81% cases of benign neoplasm and 19% malignant neoplasm in presented material. (2) The result of parotid gland treatment depends on tumor's histopathology, the period of disease, the size of tumour, its expansion into the neighbourhood, infiltrating of the facial nerve and metastases into the lymph nodes. (3) Radical resection of tumour and metastases, reconstructing the continuity of tissues and maintaining the quality of patients life, should be the principle of surgical treatment.

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  • (PMID = 18837210.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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84. Han L, Zhang X, Qiu S, Li X, Xiong W, Zhang Y, Qu H, Chang R, Chen B, Wang W, Li S: Magnetic resonance imaging of primary cerebral gliosarcoma: a report of 15 cases. Acta Radiol; 2008 Nov;49(9):1058-67
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  • BACKGROUND: Gliosarcomas are rare tumors with mixed glial and mesenchymal components.
  • RESULTS: Apart from one tumor in the right cerebellar hemisphere, all were supratentorial.
  • Two tumors were intraventricular, and four involved the corpus callosum.
  • The tumors were well demarcated, with an inhomogeneous or cystic appearance and moderate-to-extensive surrounding edema.
  • These findings, combined with patient age, can aid the differential diagnosis of gliosarcomas from more common primary brain tumors.

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  • (PMID = 18766496.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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85. Mărgăritescu C, Raica M, Simionescu C, Mogoantă L, Surpăţeanu M, Jaubert F, Bogdan F: Tumoral stroma of salivary pleomorphic adenoma -- histopathological, histochemical and immunohistochemical study. Rom J Morphol Embryol; 2005;46(3):211-23
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  • [Title] Tumoral stroma of salivary pleomorphic adenoma -- histopathological, histochemical and immunohistochemical study.
  • The aims of our paper were to establish the main histopathological, histochemical and immunohistochemical aspects of tumoral stroma from salivary pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / pathology. Stromal Cells / pathology


86. Papadogeorgakis N, Kalfarentzos EF, Vourlakou C, Malta F, Exarhos D: Simultaneous pleomorphic adenoma of the left parotid gland and adenoid cystic carcinoma of the contralateral sublingual salivary gland: a case report. Oral Maxillofac Surg; 2009 Dec;13(4):221-4
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  • [Title] Simultaneous pleomorphic adenoma of the left parotid gland and adenoid cystic carcinoma of the contralateral sublingual salivary gland: a case report.
  • INTRODUCTION: Sublingual salivary gland neoplasms are extremely rare, accounting for only 0.3-1% of all epithelial salivary gland tumors.
  • Most of the sublingual tumors are malignant, adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) being the most common histological types.
  • The coexistence of two salivary gland tumors located in different major salivary glands is uncommon.
  • CASE REPORT: A rare case of two simultaneous tumors of the major salivary glands, one in the sublingual and the other in the contralateral parotid gland in a female patient is reported.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Sublingual Gland Neoplasms / pathology

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  • (PMID = 19690903.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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87. Franko A, Magliocco AM, Duan Q, Duggan MA: WT1 immunoprofiling and comparison of malignant Mullerian mixed tumors of the female genital tract. Int J Gynecol Pathol; 2010 Sep;29(5):452-8
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  • [Title] WT1 immunoprofiling and comparison of malignant Mullerian mixed tumors of the female genital tract.
  • A malignant Mullerian mixed tumor (MMMT) is a biphasic homologous or heterologous malignancy of the female genital tract.
  • WT1 (Wilms tumor 1) is both a tumor suppressor gene and oncogene overexpressed in the nuclei of some gynecologic carcinomas.
  • There were 7 heterologous and 9 homologous tumors and 10 were endometrial, 5 were ovarian, and 1 was of peritoneal origin.
  • The tissue and cell staining pattern and score (intensity by amount) were evaluated and correlated with the tumor subtype and anatomic location.
  • Among the 16 tumors, 81.3% showed mostly stromal and cytoplasmic staining and a score of 3 or 6.
  • Staining was positive in 80% of the endometrial and ovarian tumors and the 1 peritoneal tumor and in all heterologous and 66.7% of the homologous tumors.
  • The immunoprofile correlated with tumor subtype but not with anatomic location.
  • Stromal and epithelial staining was more frequent (83.3%) in homologous tumors and differed significantly (P=0.009) from the heterologous types where stromal staining prevailed (85.7%).
  • MMMT is another genital tract malignancy which can over express WT1 and the immunoprofile may assist in tumor subtyping.
  • [MeSH-major] Genital Neoplasms, Female / metabolism. Genital Neoplasms, Female / pathology. Mixed Tumor, Mullerian / metabolism. Mixed Tumor, Mullerian / pathology. WT1 Proteins / biosynthesis

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  • (PMID = 20736771.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / WT1 Proteins
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88. Pirola E, Vergani F, Casiraghi P, Leone EB, Guerra P, Sganzerla EP: Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine. J Neurosurg Spine; 2009 Apr;10(4):329-33
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  • [Title] Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine.
  • Phosphaturic mesenchymal tumors that cause the paraneoplastic syndrome known as oncogenic osteomalacia are rare.
  • The authors report on the case of a 57-year-old man with a history of osteomalacia and in whom was diagnosed a thoracic spine tumor at the T-4 level.
  • Complete tumor resection was accomplished.
  • The histological diagnosis was phosphaturic mesenchymal tumor (mixed connective tissue variant).
  • At the 24-month follow-up, no recurrence of the disease was observed.

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  • (PMID = 19441990.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Gopalan R, Dassoulas K, Rainey J, Sherman JH, Sheehan JP: Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomas. Neurosurg Focus; 2008;24(5):E5
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  • The management of craniopharyngioma involves balancing adequate reduction in tumor volume and prevention of recurrence while minimizing damage to delicate surrounding structures.
  • Gamma Knife surgery (GKS) is now being considered as a viable method of providing tumor control while ensuring minimal side effects.
  • Tumor control was achieved in 75% of cases overall and varied with tumor subtype (cystic, solid, mixed).
  • Control was seen in 90% of solid, 80% of cystic, and 59% of mixed tumors.

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  • (PMID = 18447744.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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90. Ballas KD, Rafailidis SF, Demertzidis C, Alatsakis MB, Pantzaki A, Sakadamis AK: Mixed exocrine-endocrine tumor of the pancreas. JOP; 2005 Sep;6(5):449-54
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  • [Title] Mixed exocrine-endocrine tumor of the pancreas.
  • Tumors with mixed exocrine and endocrine components are unusual.
  • We herein describe a case of a mixed ductal-endocrine tumor.
  • Upper gastrointestinal endoscopy revealed gastric fundus varices and CT scan demonstrated an inhomogeneous tumor located in the tail of the pancreas infiltrating the spleen and the splenic vein.
  • Pathological examination revealed a mixed ductal-endocrine tumor.
  • CONCLUSIONS: Because of the rarity and unpredictable biologic behavior of these tumors, the need for adjuvant therapy has not yet been well-defined.
  • The patient has had a follow-up CT scan every six months, and one and a half years later remains disease free.
  • [MeSH-major] Carcinoma, Islet Cell / pathology. Carcinoma, Pancreatic Ductal / pathology. Mixed Tumor, Malignant / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 16186667.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Chromogranins; 0 / Gastrins; 51110-01-1 / Somatostatin; 9007-92-5 / Glucagon; EC 4.2.1.11 / Phosphopyruvate Hydratase
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91. de Araújo VC, Altemani A, Furuse C, Martins MT, de Araújo NS: Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncol; 2006 Nov;42(10):1011-6
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  • [Title] Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma.
  • The myoepithelial cell (MC) is a component of various secretory glands, including salivary glands.
  • Besides its function, a tumor suppressor and a tumor facilitating functions have been attributed to this cell.
  • We investigated the immunoprofile of benign MC in intraductal areas of carcinoma ex-pleomorphic adenoma (CXPA), comparing them with the MC in duct-like areas of pleomorphic adenoma, origin of the malignant tumor.
  • The immunohistochemical reactions of all the antibodies showed stronger staining in benign MC surrounding the malignant epithelial cells than in benign MC in duct-like areas of pleomorphic adenoma, thus revealing that in the malignization process the benign MC become differentiated and produce important proteins related to the tumor suppressor function.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Biomarkers, Tumor / metabolism. Neoplasm Proteins / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Cell Differentiation. Disease Progression. Epithelial Cells / metabolism. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged

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  • (PMID = 16757205.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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92. Kerimoglu U, Aydingoz U, Ozkaya O, Aksu AE, Ergen FB: MRI of a benign chondroid syringoma. Br J Radiol; 2006 Aug;79(944):e59-61
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  • [Title] MRI of a benign chondroid syringoma.
  • Chondroid syringoma, also known as mixed tumour of the skin, is a relatively rare, usually benign tumour.
  • A few malignant cases, especially in the lower extremities, have been published, but most of them behave in a benign fashion.
  • A case of a middle-aged woman with surgically proved chondroid syringoma in the pretibial region is presented in this report with MRI and histological findings.
  • Despite rapid growth over a short period of time and a location reportedly associated with malignancy, the histological features were benign.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16861320.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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93. Köybaşı S, Süslü AE, Tezcan E, Atasoy HI, Biçer YÖ, Boran Ç: Submandibular gland pleomorphic adenoma in a seven-year-old child: a case report. Kulak Burun Bogaz Ihtis Derg; 2010 Jul-Aug;20(4):210-3
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  • [Title] Submandibular gland pleomorphic adenoma in a seven-year-old child: a case report.
  • Salivary gland neoplasms are rare in the pediatric age group.
  • Pleomorphic adenomas in the submandibular gland are rarer.
  • The firm, mobile and painless mass was about 2x3 cm in size and with bimanual palpation it was indiscriminated from the submandibular gland.
  • Magnetic resonance imaging with contrast revealed a heterogeneous and minimally lobulated mass within the submandibular gland with clearly defined borders.
  • Fine needle aspiration biopsy revealed a diagnosis of pleomorphic adenoma and we performed right submandibular gland excision under general anesthesia.
  • The histopathological diagnosis was pleomorphic adenoma with sparse mitotic figures that may be interpreted as having a potential of malignant transformation.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Submandibular Gland Neoplasms / surgery
  • [MeSH-minor] Child. Female. Humans. Magnetic Resonance Imaging. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery. Salivary Glands / pathology. Treatment Outcome

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  • (PMID = 20626331.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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94. Wagner M, Klussmann JP, Dirsch O, Rose VA, Guntinas-Lichius O, Theegarten D, Sudhoff H, Linder R: Low prevalence of transfusion transmitted virus (TTV)-like DNA sequences in cystadenolymphoma and pleomorphic adenoma of the salivary glands. Eur Arch Otorhinolaryngol; 2006 Aug;263(8):759-63
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  • [Title] Low prevalence of transfusion transmitted virus (TTV)-like DNA sequences in cystadenolymphoma and pleomorphic adenoma of the salivary glands.
  • The present study was conducted to determine whether TTV-like DNA sequence elements play a role in the pathogenesis of cystadenolymphoma or pleomorphic adenoma and if the parotid or the submandibular gland is a major source of TTV persistence.
  • Sixty-two archival salivary gland samples (16 cystadenolymphomas, 13 pleomorphic adenomas, and 33 controls) and 23 corresponding saliva samples were examined using a polymerase chain reaction (PCR) for TTV DNA.
  • TTV appears to be only a bystander in cystadenolymphoma, pleomorphic adenoma, and other salivary gland affections.
  • [MeSH-major] Adenolymphoma / virology. Adenoma, Pleomorphic / virology. DNA, Viral / analysis. Salivary Gland Neoplasms / virology. Torque teno virus / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Base Sequence. Case-Control Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Molecular Sequence Data. Parotid Gland / pathology. Parotid Gland / virology. Polymerase Chain Reaction. Prevalence. Saliva / virology. Sequence Analysis, DNA. Submandibular Gland / pathology. Submandibular Gland / virology

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  • [ErratumIn] Eur Arch Otorhinolaryngol. 2006 Nov;263(11):1060
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  • (PMID = 16703387.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Viral
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95. Dhanuthai K, Boonadulyarat M, Jaengjongdee T, Jiruedee K: A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med; 2009 Jul;38(6):495-500
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  • [Title] A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais.
  • BACKGROUND: There have been several epidemiologic studies on intra-oral salivary gland tumors in several countries, but little is known of these tumors in Thailand.
  • OBJECTIVES: To determine the relative frequency and distribution of various types of intra-oral salivary gland tumors in the Thai population.
  • METHODS: The files of the Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, from 1969 to 2007 were searched for intra-oral salivary gland tumors.
  • Histopathologic slides were reviewed and reclassified according to the 2005 WHO Classification of Head and Neck Tumors.
  • The age, gender, race, and anatomical distribution of the tumors were collected from the patients' records.
  • RESULTS: Of the 16,358 accessioned cases, 311 cases (1.90%) were diagnosed as intra-oral salivary gland tumors.
  • One hundred and forty-seven cases (47.27%) were benign tumors, while 164 cases (52.73%) were malignant tumors.
  • Pleomorphic adenoma was the most common intra-oral salivary gland tumor.
  • CONCLUSIONS: Pleomorphic adenoma is the most common intra-oral salivary gland tumor and the most common benign intra-oral salivary gland tumor, while mucoepidermoid carcinoma is the most common malignant intra-oral salivary gland tumor.
  • Intra-oral salivary gland tumors in Thailand elicit similar trend as in previous studies, with only minor differences such as the ranking of some tumors, the higher incidence of intra-bony location, and the lower incidence of polymorphous low-grade adenocarcinoma.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Incidence. Male. Middle Aged. Palatal Neoplasms / epidemiology. Retrospective Studies. Sex Factors. Thailand / epidemiology. Young Adult

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  • (PMID = 19594840.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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96. Nakajima Y, Kishimoto T, Nagai Y, Yamada M, Iida Y, Okamoto Y, Ishida Y, Nakatani Y, Ichinose M: Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland. Pathology; 2009;41(7):634-9
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  • [Title] Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland.
  • The expression of AR has been reported in carcinoma ex pleomorphic adenoma (CXPA) of salivary gland, however AR gene status and the expressions of cofactors for AR signalling have not been investigated.
  • METHODS: Ten cases of CXPA and 23 cases of pleomorphic adenomas (PA) of the salivary glands were immunostained for the AR co-regulators (SRC1, p300, and NCoR1) and the signalling molecules involved in the ligand-independent pathway (i.e., HER-2/neu and STAT3).
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Carcinoma / genetics. Neoplasms, Second Primary / genetics. Receptor, ErbB-2 / genetics. Receptors, Androgen / genetics. STAT3 Transcription Factor / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. DNA, Neoplasm. Female. Gene Amplification. Gene Expression Regulation, Neoplastic. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Polymorphism, Restriction Fragment Length. Signal Transduction


97. Rossi Izquierdo M, Frade González C, Cabanas Rodríguez E, Dios Loureiro C, Lozano Ramírez A, Labella Caballero T: [Our experience in the treatment of the tumors of parotid gland]. An Otorrinolaringol Ibero Am; 2007;34(3):257-71
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  • [Title] [Our experience in the treatment of the tumors of parotid gland].
  • [Transliterated title] Nuestra experiencia en el tratamiento de los tumores de glándula parótida.
  • We analyse our results in the treatment of the tumors of the parotid gland, diagnosticated from 1981 till end of 2004.
  • We saw 132 patients with tumors of the parotid, being 41 of them malignant.
  • The global survival obtained in the malignant tumors was 60% after five years.
  • Surgery is the treatment of election in the tumors of epitelial origin of the parotid gland.
  • [MeSH-major] Adenolymphoma / surgery. Adenoma, Pleomorphic / surgery. Carcinoma, Mucoepidermoid / surgery. Carcinoma, Squamous Cell / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Parotid Gland / pathology. Parotid Gland / surgery. Postoperative Complications. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 17725170.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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98. Seijas R, Ares O, Sierra J, Pérez-Dominguez M: Oncogenic osteomalacia: two case reports with surprisingly different outcomes. Arch Orthop Trauma Surg; 2009 Apr;129(4):533-9
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  • This condition is usually associated with a phosphaturic mesenchymal tumor of mixed connective tissue located in the bone or soft tissue.
  • We present two cases of oncogenic osteomalacia associated with phosphaturic mesenchymal tumors, which were histologically similar, but presented a completely different evolution.
  • In the first patient, the tumor developed on the sole of the foot.
  • However, in the second patient, a liver tumor developed and resection did not resolve the disease.
  • This disease usually remits with complete tumor resection.
  • If scintigraphy of the tumor shows octreotide receptors, patients may respond partially to therapy with somatostatin analogs, with stabilization of the lesion.

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  • (PMID = 19125258.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Indium Radioisotopes; 0 / Receptors, Somatostatin; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide; RWM8CCW8GP / Octreotide
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99. Tsutsumi S, Kondo A, Yasumoto Y, Ito M: Rapid growth of congenital diffuse brain tumor considered to be teratoma: case report. Neurol Med Chir (Tokyo); 2008 Jul;48(7):322-5
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  • [Title] Rapid growth of congenital diffuse brain tumor considered to be teratoma: case report.
  • Prenatal ultrasonography of a 17-year-old pregnant female detected ventriculomegaly of the fetus at 31 weeks of gestation.
  • Computed tomography performed on postnatal day 5 revealed a massive brain tumor of mixed density, with multiple lobulation and cystic and calcified components.
  • The tumor had rapidly grown with diffuse appearance.
  • The tumor appeared hypervascular and bled profusely on resection maneuver, so the endoscopic procedure for histological verification was abandoned.
  • Neuroimaging performed on postnatal day 11 indicated significant additional tumor growth which occupied nearly the whole cranial cavity.
  • [MeSH-minor] Adolescent. Biopsy. Endoscopy. Fatal Outcome. Female. Humans. Hydrocephalus / pathology. Infant, Newborn. Male. Pregnancy. Tumor Burden. Ventriculostomy

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  • (PMID = 18654054.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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100. Augello C, Gregorio V, Bazan V, Cammareri P, Agnese V, Cascio S, Corsale S, Calò V, Gullo A, Passantino R, Gargano G, Bruno L, Rinaldi G, Morello V, Gerbino A, Tomasino RM, Macaluso M, Surmacz E, Russo A: TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas. J Cell Physiol; 2006 Jun;207(3):654-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.
  • The putative role of TP53 and p16(INK4A) tumor suppressor genes and Ras oncogenes in the development and progression of salivary gland neoplasias was studied in 28 cases of pleomorphic adenomas (PA), 4 cases of cystic adenocarcinomas, and 1 case of carcinoma ex-PA.
  • All genetic and epigenetic alterations were detected exclusively in the epithelial and transitional tumor components, and were absent in the mesenchymal parts.
  • [MeSH-major] Adenoma / genetics. Adenoma / pathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Base Sequence. Disease Progression. Epigenesis, Genetic / genetics. Genotype. Humans. Methylation. Mutation / genetics. Proto-Oncogene Proteins p21(ras) / genetics

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16447252.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p53; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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