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1. Ikeda Y, Takayama J, Takami H: Minimally invasive radioguided parathyroidectomy for hyperparathyroidism. Ann Nucl Med; 2010 May;24(4):233-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive radioguided parathyroidectomy for hyperparathyroidism.
  • Clinical or subclinical hyperparathyroidism (HPT) is one of the most common endocrine disorders.
  • In patients with HPT who meet the indications for parathyroidectomy, complete surgical resection of all hyperfunctioning parathyroid tissue is essential for the curative treatment.
  • The conventional surgical approach is bilateral neck exploration, whereas minimally invasive parathyroidectomy has been made possible by the introduction of (99m)Tc-sestamibi scintigraphy for preoperative localization of parathyroid adenomas.
  • In minimally invasive surgery, the surgeon expects some modalities that predict complete resection of all hyperfunctioning parathyroid glands.
  • The prevalence rate of (99m)Tc-sestamibi scanning for single parathyroid adenoma was widely accepted as 85-95%.
  • Intraoperative navigation using these devices provides the possibility of easy and definitive identification of parathyroid nodules during the operation.
  • [MeSH-major] Hyperparathyroidism / surgery. Minimally Invasive Surgical Procedures / methods. Parathyroidectomy / methods. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Humans. Intraoperative Period. Parathyroid Hormone / metabolism

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  • (PMID = 20333484.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  • [Number-of-references] 45
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2. Domínguez JM, Velasco S, Goñi I, León A, González H, Claure R, Arteaga E, Campusano C, Fardella C, López JM, Mosso L, Rodríguez JA, González G: [Usefulness of intraoperative parathormone measurement to predict surgical cure in primary hyperparathyroidism]. Rev Med Chil; 2009 Dec;137(12):1591-6
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  • [Title] [Usefulness of intraoperative parathormone measurement to predict surgical cure in primary hyperparathyroidism].
  • [Transliterated title] Utilidad de la PTH intraoperatoria como predictor de curación quirúrgica en hiperparatiroidismo primario.
  • BACKGROUND: The aim of the surgical treatment of primary hyperparathyroidism (PHPT) is to achieve its complete cure, evidenced by normal serum calcium in the postoperative period.
  • MATERIAL AND METHODS: Serum PTH was measured to all patients operated for PHPT between 2003 and 2008, before and five and ten minutes after the excision of the parathyroid gland causing the disease.
  • The criteria for complete cure were normal serum calcium at 24 hours and 6 months after surgery and the pathological confirmation of parathyroid gland excision.
  • The pathological study disclosed an adenoma in 69 (78%), and multiglandular disease in 16 (18%), a parathyroid cancer in one and a normal gland in one patient.
  • Intraoperative PTH predicted early and definitive cure in 97% and 100% of patients with a single adenoma, respectively.
  • [MeSH-major] Adenoma / surgery. Calcium / blood. Hyperparathyroidism / surgery. Parathyroid Hormone / blood. Parathyroid Neoplasms / surgery

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  • (PMID = 20361135.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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3. Abraham D, Duick DS, Baskin HJ: Appropriate administration of fine-needle aspiration (FNA) biopsy on selective parathyroid adenomas is safe. Thyroid; 2008 May;18(5):581-2; author reply 583-4
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  • [Title] Appropriate administration of fine-needle aspiration (FNA) biopsy on selective parathyroid adenomas is safe.
  • [MeSH-major] Adenoma / pathology. Biopsy, Fine-Needle / adverse effects. Parathyroid Neoplasms / pathology

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  • [CommentOn] Thyroid. 2007 Dec;17(12):1251-5 [17887929.001]
  • (PMID = 18466081.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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4. Kovacs K, Bell CD, Juco J, Rotondo F, Anderson J: Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism. Endocr Pathol; 2007;18(1):42-5
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  • [Title] Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism.
  • We report here the case of a 43-year-old woman with hyperparathyroidism, parathyroid chief cell adenoma, and massive chronic parathyroiditis.
  • The question can be raised whether chemotherapeutic agents may damage parathyroid cells leading to loss of self-tolerance and autoimmune chronic parathyroiditis.
  • [MeSH-major] Adenoma / pathology. Hyperparathyroidism / pathology. Parathyroid Glands / pathology. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Calcium / blood. Chronic Disease. Humans. Inflammation / pathology. Inflammation / surgery. Male. Parathyroid Hormone / blood. Treatment Outcome

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  • (PMID = 17652800.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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5. Prasannan S, Davies G, Bochner M, Kollias J, Malycha P: Minimally invasive parathyroidectomy using surgeon-performed ultrasound and sestamibi. ANZ J Surg; 2007 Sep;77(9):774-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Surgeon-performed ultrasound (SPU) and (99m)Tc-sestamibi (SM) scanning can be used alone or in combination in patients with primary hyperparathyroidism to select cases suitable for minimally invasive parathyroidectomy (MIP).
  • METHODS: The study was a prospective analysis of 130 patients with primary hyperparathyroidism who had preoperative localization with SPU and SM at a tertiary referral centre between 2003 and 2006.
  • SPU alone identified the abnormal parathyroid in 103 cases (sensitivity 82%; positive predictive value 96.3%).
  • SM alone identified the abnormal gland in 102 cases (sensitivity 79%; positive predictive value 99%).
  • CONCLUSION: SPU in the hands of an experienced surgeon in association with sestamibi is a reliable tool for the preoperative localization of parathyroid adenomas and facilitates a minimally invasive procedure.
  • [MeSH-major] Hyperparathyroidism, Primary / diagnosis. Hyperparathyroidism, Primary / surgery. Parathyroidectomy

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  • (PMID = 17685957.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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6. Cohen MS, Finkelstein SE, Brunt LM, Haberfeld E, Kangrga I, Moley JF, Lairmore TC: Outpatient minimally invasive parathyroidectomy using local/regional anesthesia: a safe and effective operative approach for selected patients. Surgery; 2005 Oct;138(4):681-7; discussion 687-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Minimally invasive parathyroidectomy (MIP) using local/regional anesthesia has become an accepted treatment for selected patients with primary hyperparathyroidism (HPT) and can be performed in the ambulatory setting.
  • METHODS: From 1999 to 2004, 139 consecutive patients at our institution with HPT caused by a single localized parathyroid adenoma underwent MIP through a 2.5- to 3-cm incision.
  • RESULTS: All 139 MIP patients had biochemical HPT and a single adenoma localized by sestamibi scan alone (n = 119; 86%) or combined with other imaging (n = 20; 14%).
  • The mean adenoma size was 1,184 +/- 1,091 mg.
  • Total calcium and parathyroid hormone levels were 11.3 +/- 0.8 mg/dL and 451 pg/mL preoperatively, respectively, decreasing to 9.4 +/- 0.6 mg/dL and 34 pg/mL postoperatively, respectively.
  • A low morbidity (0.7% in this series), rapid recovery, and high biochemical cure rate (98.6%) parallels 4-gland exploration under general anesthesia.
  • [MeSH-major] Adenoma / surgery. Ambulatory Surgical Procedures. Anesthesia, Conduction. Anesthesia, Local. Minimally Invasive Surgical Procedures. Parathyroid Neoplasms / surgery. Parathyroidectomy

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  • (PMID = 16269297.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Reséndiz-Colosia JA, Alvarado-Cabrero I, Flores-Díaz R, Juan MH, Barroso-Bravo S, Gómez-Acosta F, Rodríguez-Cuevas SA: [Multiple maxillofacial brown tumors as primary hyperparathyroidism manifestation]. Gac Med Mex; 2008 Mar-Apr;144(2):155-60
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  • [Title] [Multiple maxillofacial brown tumors as primary hyperparathyroidism manifestation].
  • [Transliterated title] Múltiples tumores pardos maxilofaciales como manifestación de hiperparatiroidismo primario.
  • OBJECTIVE: In order to analyze the differential diagnosis of giant-cell lesion in facial bones, we present a case of a patient without a previously diagnosed primary hyperparathyroidism that displayed multiple maxillofacial brown tumors as the initial clinical manifestation of the disease.
  • During biochemical evaluation prior to surgery, the possibility of hyperparathyroidism was considered.
  • Using computed tomography, we noted a parathyroid tumor in an atypical location.
  • Surgical resection confirmed the presence of an adenoma.
  • CONCLUSION: The detection of giant-cell bone lesions in the maxillofacial region is a strategic diagnostic finding as several entities, among these brown tumor hyperparathyroidism can display similar histologic imaging findings.
  • Only systematic clinical, radiologic, and biochemical evaluation can allow for a definitive diagnosis.
  • The presence of multiple simultaneous maxillofacial brown tumors in primary hyperparathyroidism is an infrequent ocurrence, and only on rare occasions can this be the first sign of the disease.
  • [MeSH-major] Hyperparathyroidism, Primary / complications. Mandibular Neoplasms / etiology. Maxillary Neoplasms / etiology. Neoplasms, Multiple Primary / etiology. Parathyroid Neoplasms / etiology

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  • (PMID = 18590035.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 20
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8. Radan L, Gorenberg M: The value of SPECT/CT 99mTc-sestamibi scintigraphy in the diagnosis of ectopic parathyroid adenoma. Isr Med Assoc J; 2009 Jul;11(7):448
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of SPECT/CT 99mTc-sestamibi scintigraphy in the diagnosis of ectopic parathyroid adenoma.
  • [MeSH-major] Adenoma / radionuclide imaging. Choristoma / radionuclide imaging. Parathyroid Glands. Parathyroid Neoplasms / radionuclide imaging. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 19911503.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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9. Rubello D, Giannini S, Martini C, Piotto A, Rampin L, Fanti S, Armigliato M, Nardi A, Carpi A, Mariani G, Gross MD, Pelizzo MR: Minimally invasive radio-guided parathyroidectomy. Biomed Pharmacother; 2006 Apr;60(3):134-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We reported here the data on minimally invasive radio-guided parathyroidectomy (MIRP) in a large group of 253 patients enrolled from the whole series of 355 consecutive patients affected by primary hyperparathyroidism (P-HPT) referred to our center.
  • On the basis of preoperative imaging including Sestamibi scintigraphy and neck ultrasound (US), 263 patients (74% of the whole series) with evidence of a solitary parathyroid adenoma (PA) and a normal thyroid gland were addressed to MIRP and in 253 (96%) of them this minimally invasive neck exploration was successfully performed.
  • In conclusion, MIRP is an effective treatment in patients with a high likelihood of a solitary PA and a normal thyroid gland at scintigraphy and US so that an accurate preoperative localizing imaging is required for MIRP.
  • [MeSH-major] Adenoma / surgery. Gamma Cameras. Hyperparathyroidism, Primary / surgery. Minimally Invasive Surgical Procedures. Parathyroid Neoplasms / surgery. Parathyroidectomy. Radiology, Interventional / instrumentation

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  • (PMID = 16524690.001).
  • [ISSN] 0753-3322
  • [Journal-full-title] Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
  • [ISO-abbreviation] Biomed. Pharmacother.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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10. Dupuy O, Aubert P, Dumuis ML, Bordier L, Mayaudon H, Bauduceau B: [Hyperparathyroidism during pregnancy: dangerous association for the mother and her infant]. Rev Med Interne; 2010 Nov;31(11):e9-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hyperparathyroidism during pregnancy: dangerous association for the mother and her infant].
  • [Transliterated title] Hyperparathyroïdie et grossesse : association à risque pour la mère et l'enfant.
  • Hypercalcaemia during pregnancy is rare but requires a systematic approach for its diagnosis and its treatment.
  • We report a 32-year-old pregnant female at 32 weeks of gestation who presented a severe hypercalcaemia, due to primary hyperparathyroidism.
  • Eight days later, the mother was operated from a parathyroid adenoma allowing normalisation of calcaemia.
  • Hyperparathyroidism during pregnancy is rarely reported; it can lead to severe complications for both the mother and the infant.

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  • [Copyright] Copyright © 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20554087.001).
  • [ISSN] 1768-3122
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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11. Juhlin CC, Villablanca A, Sandelin K, Haglund F, Nordenström J, Forsberg L, Bränström R, Obara T, Arnold A, Larsson C, Höög A: Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification. Endocr Relat Cancer; 2007 Jun;14(2):501-12
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  • [Title] Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification.
  • Parafibromin is a protein product derived from the hyperparathyroidism 2(HRPT2) tumor suppressor geneand its inactivation has been coupled to familial and sporadic forms of parathyroid malignancy.
  • In this study, we have conducted immunohistochemistry on 33 parathyroid carcinomas (22 unequivocal and 11 equivocal) using four parafibromin antibodies directed to different parts of the protein.
  • Our findings show that 68% (15 out of 22) of the unequivocal carcinomas exhibited reduced expression of parafibromin while the 25 sporadic adenomas used as controls were entirely positive for parafibromin expression.
  • We conclude that parafibromin immunohistochemistry could be used as an additional marker for parathyroid tumor classification, where positive samples have low risk of malignancy, whereas samples with reduced expression could be either carcinomas or rare cases of adenomas likely carrying an HRPT2 mutation.
  • [MeSH-major] Adenoma / classification. Adenoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma / classification. Carcinoma / diagnosis. Parathyroid Neoplasms / classification. Parathyroid Neoplasms / diagnosis. Tumor Suppressor Proteins / analysis

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  • (PMID = 17639063.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers, Tumor; 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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12. Shpitzer T, Saute M, Gilat H, Raveh E, Koren I, Shvero J, Bahar G, Feinmesser R: Adaptation of median partial sternotomy in head and neck surgery. Am Surg; 2007 Dec;73(12):1275-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The 17 patients included 11 adults with metastatic thyroid disease (six metastatic papillary thyroid carcinoma, two medullary carcinoma, and one Hiirthle cell carcinoma) and huge retrosternal goiter (n = 2), four adults with parathyroid disease (two primary parathyroid adenoma, one secondary hyperplasia, and one parathyroid carcinoma), and two children with lymphangioma and huge thymic cyst (one each).

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  • (PMID = 18186389.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Gold JS, Donovan PI, Udelsman R: Partial median sternotomy: an attractive approach to mediastinal parathyroid disease. World J Surg; 2006 Jul;30(7):1234-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Partial median sternotomy: an attractive approach to mediastinal parathyroid disease.
  • BACKGROUND: Parathyroid exploration through a standard cervical approach is adequate for the resection of most mediastinal parathyroid glands.
  • A subset of mediastinal parathyroid glands causing hyperparathyroidism, however, cannot be removed in this manner.
  • RESULTS: Over a 14-year period, all but 10 of 937 (1.1%) consecutive patients explored for hyperparathyroidism by a single endocrine surgeon were treated by a cervical approach.
  • Six of these seven patients had failed a previous parathyroid exploration (86%), including one patient who had a previous complete sternotomy.
  • Cure of hyperparathyroidism was achieved in all seven patients undergoing partial median sternotomy.
  • In five patients a mediastinal parathyroid gland was removed (71%), and in one patient a parathyroid adenoma in the carotid sheath was eventually found, and the location of the hyperfunctioning parathyroid gland in one patient was never determined although the patient was cured.
  • CONCLUSIONS: Rarely, mediastinal parathyroid glands cannot be resected through a cervical approach.
  • In these cases the use of partial median sternotomy is an attractive technique in achieving cure of hyperparathyroidism and is associated with minimal morbidity and a short length of hospital stay.
  • [MeSH-major] Hyperparathyroidism / surgery. Mediastinal Diseases / surgery. Sternum / surgery

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  • (PMID = 16794907.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Pino Rivero V, Trinidad Ruiz G, Pardo Romero G, Pantoja Hernández CG, González Palomino A, Marcos García M, Keituqwa Yáñez T, Blasco Huelva A: [Association between primary hyperparathyroidism and Paget's disease. Report of a case]. An Otorrinolaringol Ibero Am; 2005;32(4):317-22
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  • [Title] [Association between primary hyperparathyroidism and Paget's disease. Report of a case].
  • [Transliterated title] Asociación entre hiperparatiroidismo primario y enfermedad de paget Presentación de un caso.
  • Although the association between hyperparathyroidism and Paget's disease is known, in the clinical practice occurs very rarely.
  • We report the case of a 68 years old female who was diagnosed as such disease more than 5 years ago and later she got an increment of PTH levels and hypercalcemiajoint to other biochemical disorders that made to suspect a primary hyperparathyroidism.
  • She was operated by removal of one adenoma (1,5 cm) located in lower right parathyroid gland and her evolution was satisfactory without complications.
  • [MeSH-major] Hyperparathyroidism / complications. Osteitis Deformans / complications
  • [MeSH-minor] Aged. Antimetabolites / therapeutic use. Calcitonin / therapeutic use. Clodronic Acid / therapeutic use. Female. Humans. Lumbar Vertebrae / radiography. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 16156361.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antimetabolites; 0813BZ6866 / Clodronic Acid; 9007-12-9 / Calcitonin
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15. Nabbout LA, Salti IS, Choucair MK: An unusual case of autonomous hyperparathyroidism in a patient with X-linked hypophosphatemic rickets and Kallmann syndrome. Am J Med Sci; 2009 Feb;337(2):134-7
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  • [Title] An unusual case of autonomous hyperparathyroidism in a patient with X-linked hypophosphatemic rickets and Kallmann syndrome.
  • Despite a dramatic response, the course of treatment was complicated by secondary hyperparathyroidism and, 13 years later, by the development of an autonomous parathyroid adenoma that was surgically resected.
  • [MeSH-major] Familial Hypophosphatemic Rickets / complications. Genetic Diseases, X-Linked. Hyperparathyroidism, Secondary / etiology. Kallmann Syndrome / complications
  • [MeSH-minor] Adolescent. Alkaline Phosphatase / blood. Calcium / blood. Humans. Male. Parathyroid Hormone / blood. Phosphates / administration & dosage. Phosphates / adverse effects. Phosphorus / blood. Time Factors

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  • (PMID = 19214032.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Phosphates; 27YLU75U4W / Phosphorus; EC 3.1.3.1 / Alkaline Phosphatase; SY7Q814VUP / Calcium
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16. Mauz PS, Stiegler M, Holderried M, Brosch S: Complications of ultrasound guided percutaneous ethanol injection therapy of the thyroid and parathyroid glands. Ultraschall Med; 2005 Apr;26(2):142-5
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  • [Title] Complications of ultrasound guided percutaneous ethanol injection therapy of the thyroid and parathyroid glands.
  • OBJECTIVES: Since 1990 percutaneous ethanol injection therapy (PEIT) has been applied clinically as a treatment strategy for focal and diffuse autonomy of the thyroid, for cystic lesions and for ablation of parathyroid hyperplasia (PEA).
  • CONCLUSIONS: PEIT for focal and diffuse autonomy, for cystic lesions of the thyroid, for thyroid hyperplasia and PEA for parathyroid hyperplasia are methods which are inexpensive and can be performed on an ambulatory base.
  • [MeSH-major] Adenoma / ultrasonography. Ethanol / therapeutic use. Injections, Jet / methods. Parathyroid Diseases / ultrasonography. Skin / ultrastructure. Thyroid Neoplasms / ultrasonography

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  • (PMID = 15852178.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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17. Muthukrishnan J, Verma A, Modi KD, Kumaresan K, Jha S: Ectopic parathyroid adenoma--the hidden culprit. J Assoc Physicians India; 2007 Jul;55:515-8
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  • [Title] Ectopic parathyroid adenoma--the hidden culprit.
  • Primary Hyperparathyroidism is known to present with protean manifestations leading to misdiagnosis in the initial stages of the disease.
  • Inability to locate the adenoma in an ectopic parathyroid gland may further delay the diagnosis of these cases.
  • Aberrant migration during development may lead to intrathyroidal or other ectopic locations of parathyroid glands.
  • Similarity in cytological picture between thyroids and parathyroids may further complicate diagnosis by fine needle aspiration cytology.
  • We encountered three such cases with the parathyroid gland adenomas in ectopic locations in which pre-operative nuclear imaging played a major role.
  • [MeSH-major] Hyperparathyroidism, Primary / diagnosis. Parathyroid Glands / pathology. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 17907504.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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18. Chen H, Pruhs Z, Starling JR, Mack E: Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy. Surgery; 2005 Oct;138(4):583-7; discussion 587-90
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  • [Title] Intraoperative parathyroid hormone testing improves cure rates in patients undergoing minimally invasive parathyroidectomy.
  • BACKGROUND: Intraoperative parathyroid hormone (iPTH) testing often is used during minimally invasive parathyroidectomy for primary hyperparathyroidism (1 degrees HPT).
  • From January 1990 to June 2004, there were 345 consecutive patients with 1 degrees HPT and positive localization studies for a single parathyroid adenoma who were candidates for minimally invasive parathyroidectomy.
  • Group 1 patients (n = 157) underwent parathyroid exploration without iPTH testing and group 2 patients (n = 188) had an operation with iPTH testing.
  • RESULTS: Of the group 1 patients, 15 (10%) still were hypercalcemic postoperatively owing to additional unidentified hyperfunctioning parathyroid glands.
  • In contrast, among 188 group 2 patients, 170 (90%) had resection of a single parathyroid adenoma, a greater than 50% decrease in iPTH levels, and were cured.
  • Of these 18 patients, 9 had double adenomas and 9 had 3- or 4-gland hyperplasia.
  • [MeSH-major] Hyperparathyroidism, Primary / blood. Hyperparathyroidism, Primary / surgery. Intraoperative Care. Minimally Invasive Surgical Procedures. Parathyroid Hormone / blood. Parathyroidectomy
  • [MeSH-minor] Adenoma / complications. Humans. Hyperplasia. Middle Aged. Parathyroid Glands / pathology. Parathyroid Neoplasms / complications. Retrospective Studies. Treatment Outcome

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  • (PMID = 16269285.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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19. Caron P, Maiza JC, Renaud C, Cormier C, Barres BH, Souberbielle JC: High third generation/second generation PTH ratio in a patient with parathyroid carcinoma: clinical utility of third generation/second generation PTH ratio in patients with primary hyperparathyroidism. Clin Endocrinol (Oxf); 2009 Apr;70(4):533-8
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  • [Title] High third generation/second generation PTH ratio in a patient with parathyroid carcinoma: clinical utility of third generation/second generation PTH ratio in patients with primary hyperparathyroidism.
  • BACKGROUND: Primary hyperparathyroidism (PHP) is caused by parathyroid adenomas or hyperplasia, and occasionally by parathyroid carcinoma.
  • Recently a high third generation/second generation PTH ratio has been observed in some patients with parathyroid carcinoma.
  • PATIENTS AND METHODS: We report the case of a 60-year old woman who was presented a fourth episode of PTH-related hypercalcaemia due to a parathyroid carcinoma.
  • RESULTS: Before surgery of the patient with parathyroid carcinoma, second generation PTH was 229 pg/ml, third generation PTH was 675 pg/ml and third generation/second generation PTH ratio was 2.95.
  • CONCLUSION: A high third generation/second generation PTH ratio could be observed in patients with parathyroid carcinoma, is uncommon in benign PHP and is absent in osteoporotic patients without PHP.
  • Therefore, PTH level can be measured using second and third generation assays in some PHP patients, and a specific surgical protocol for possible parathyroid carcinoma could be discussed in patients with a high third generation/second generation PTH ratio.
  • [MeSH-major] Hyperparathyroidism, Primary / blood. Parathyroid Hormone / blood. Parathyroid Neoplasms / blood

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  • [ErratumIn] Clin Endocrinol (Oxf). 2009 Oct;71(4):605
  • (PMID = 18782355.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Peptide Fragments; 0 / parathyroid hormone (7-84); SY7Q814VUP / Calcium
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20. Agarwal AM, Bentz JS, Hungerford R, Abraham D: Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients. Diagn Cytopathol; 2009 Jun;37(6):407-10
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  • [Title] Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients.
  • This study was designed to assess the utility of fine-needle aspiration cytology (FNAC) in the preoperative localization of parathyroid adenoma (PA).
  • Parathyroid hormone (PTH) estimation was performed on the supernatant of the aspirated fluid on all cases.
  • Parathyroid cells were seen in 23 samples (40.4%).
  • Majority of the samples with parathyroid cells showed moderate cellularity with monomorphous round to slightly oval cells predominantly arranged in loose two-dimensional clusters with occasional papillary fragments.
  • In conclusion, US-guided FNAC has its limitations because of low sensitivity in primary localization of the parathyroid adenoma in cases of primary hyperparathyroidism and is not a useful mode of investigation in cases of PA.
  • [MeSH-major] Parathyroid Glands / pathology. Parathyroid Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19283690.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin
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21. Sathe PA, Madiwale CV, Kandalkar BM, Bandgar TR, Shah NS, Menon PS: Primary hyperparathyroidism: a clinicopathological experience. Indian J Pathol Microbiol; 2009 Jul-Sep;52(3):313-20
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  • [Title] Primary hyperparathyroidism: a clinicopathological experience.
  • BACKGROUND: Parathyroid neoplasms form a small percentage of head and neck neoplasms.
  • Primary hyperparathyroidism is caused by parathyroid adenomas, hyperplasia or, rarely, a carcinoma.
  • RESULTS: We had 43 adenomas, three hyperplasias and two carcinomas.
  • The pre-operative diagnosis was assisted by ultrasonography in 11 cases, computerized tomography of the neck in 10 cases and sestamibi scans in three cases.
  • Intra-operative parathormone monitoring was performed in one case of adenoma.
  • There was a discrepancy between frozen section diagnosis and paraffin section diagnosis in two cases.
  • CONCLUSION: Histopathologic diagnosis is an important guide to decide the type of surgical management.
  • Although pathologic features of parathyroid carcinoma are diagnostically reliable, those of the more commonly encountered lesions of adenoma and hyperplasia may be overlapping and, therefore, indistinctive, more so if only a single gland is available for examination.
  • Because parathyroid lesions are only occasionally encountered by the surgical pathologist, awareness of the spectrum of histologic features along with knowledge of recent trends in diagnosis and surgical management are important.
  • [MeSH-major] Hyperparathyroidism, Primary / diagnosis. Hyperparathyroidism, Primary / pathology. Parathyroid Glands / pathology. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Histocytochemistry. Humans. Male. Neck / radiography. Prevalence. Retrospective Studies. Young Adult

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  • (PMID = 19679950.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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22. Aloumanis KP, Papapetrou PD: Corpus callosum aplasia in a young patient with a parathyroid adenoma. J Clin Neurosci; 2007 Nov;14(11):1124-6
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  • [Title] Corpus callosum aplasia in a young patient with a parathyroid adenoma.
  • A young man with primary hyperparathyroidism due to a parathyroid adenoma and aplasia of the corpus callosum is presented.
  • We hypothesize a possible genetic association of the two pathologies: a proportion of the sporadic parathyroid adenomas are associated with genetic abnormalities of chromosome 11 and in some cases of corpus callosum aplasia, aneuploidy or polyploidy of this chromosome has been described.
  • [MeSH-major] Adenoma / complications. Agenesis of Corpus Callosum. Brain Diseases / complications. Hyperparathyroidism, Primary / complications. Parathyroid Neoplasms / complications

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  • (PMID = 17954377.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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23. Al-Mashat F, Sibiany A, Faleh D, Kary K, Alfi AY, El-Lakany MM: Mediastinal parathyroid adenoma. Saudi J Kidney Dis Transpl; 2009 Sep;20(5):826-30
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  • [Title] Mediastinal parathyroid adenoma.
  • We present two cases that developed clinical, biochemical and radiological evidences of primary and secondary hyperparathyroidism.
  • In the first case the adenoma was removed through a transcervical incision and in the second case the supernumerary adenoma was removed through sternotomy.
  • [MeSH-major] Adenoma / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy. Sternum / surgery
  • [MeSH-minor] Adult. Biomarkers / blood. Calcium / blood. Female. Humans. Hyperparathyroidism, Primary / etiology. Hyperparathyroidism, Secondary / etiology. Magnetic Resonance Imaging. Middle Aged. Parathyroid Hormone / blood. Radiopharmaceuticals. Technetium. Technetium Tc 99m Sestamibi. Thallium Radioisotopes. Treatment Outcome

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  • (PMID = 19736482.001).
  • [ISSN] 1319-2442
  • [Journal-full-title] Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • [ISO-abbreviation] Saudi J Kidney Dis Transpl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Parathyroid Hormone; 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7440-26-8 / Technetium; 971Z4W1S09 / Technetium Tc 99m Sestamibi; SY7Q814VUP / Calcium
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24. Oliveira MA, Maeda SS, Dreyer P, Lobo A, Andrade VP, Hoff AO, Biscolla RP, Smanio P, Brandão CM, Vieira JG: [Importance of parathyroid SPECT and 99mTc scintigraphy, and of clinical, laboratorial, ultrasonographic and citologic correlation in the pre-operative localization of the parathyroid adenoma - pictorial assay]. Arq Bras Endocrinol Metabol; 2010 Jun;54(4):352-61
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  • [Title] [Importance of parathyroid SPECT and 99mTc scintigraphy, and of clinical, laboratorial, ultrasonographic and citologic correlation in the pre-operative localization of the parathyroid adenoma - pictorial assay].
  • [Transliterated title] Importância da complementação com SPECT e 99mTc na cintilografia das paratiroides e da correlação clínica, laboratorial, ultrassonográfica e citológica na localização pré-operatória do adenoma de paratiroide - ensaio pictórico.
  • OBJECTIVE: In patients with primary hyperparathyroidism, candidates for surgical intervention, the parathyroid pre-operative localization is of fundamental importance in planning the appropriate surgical approach.
  • MATERIALS AND METHODS: The additional acquisition of SPECT and Technetium-99m images, during parathyroid scintigraphy with Sestamibi, is not common practice.
  • RESULTS: In our experience, the complete protocol in parathyroid scintigraphy increases the accuracy of pre-operative parathyroid localization.
  • CONCLUSION: The complete utilization of all available nuclear medicine methods (SPECT e 99mTc) and image interpretation in a multidisciplinary context can improve the accuracy of parathyroid scintigraphy.
  • [MeSH-major] Adenoma / pathology. Adenoma / radionuclide imaging. Parathyroid Neoplasms / pathology. Parathyroid Neoplasms / radionuclide imaging. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Tomography, Emission-Computed, Single-Photon / standards

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  • [CommentIn] Arq Bras Endocrinol Metabol. 2010 Jun;54(4):343-4 [20625644.001]
  • (PMID = 20625646.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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25. Goldstein RE, Carter WM 2nd, Fleming M, Bumpous J, Lentsch E, Rice M, Flynn M: Unilateral cervical surgical exploration aided by intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism and equivocal sestamibi scan results. Arch Surg; 2006 Jun;141(6):552-7; discussion 557-9
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  • [Title] Unilateral cervical surgical exploration aided by intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism and equivocal sestamibi scan results.
  • HYPOTHESIS: Equivocal parathyroid technetium Tc 99m sestamibi scan results are likely to demonstrate the correct location for parathyroid adenomas.
  • DESIGN: Patients with primary hyperparathyroidism prospectively consented to participate in an institutional review board-approved study.
  • The parathyroid technetium Tc 99m sestamibi scan results were classified as positive, negative, or equivocal.
  • PATIENTS: Technetium Tc 99m sestamibi imaging was performed for 464 patients with primary hyperparathyroidism.
  • Eighty-four of these patients had scan results considered equivocal for unilateral adenomas.
  • The algorithm for this group of patients specified that they should receive an injection with technetium Tc 99m sestamibi prior to parathyroidectomy and that an intraoperative parathyroid hormone (iPTH) level decrease of more than 50% be used to define intraoperative success.
  • MAIN OUTCOME MEASURE: Correlation of equivocal scan interpretation with operative findings and biochemical cure of hyperparathyroidism.
  • Two failures were associated with a false-positive iPTH level decrease and 2 with failure to find the adenoma.
  • Of the other 22 patients, in addition to the 3 failures, 7 had 4-gland hyperplasia, 4 had double adenomas, and 6 had false-negative iPTH level results with iPTH level decreases of less than 50%.
  • [MeSH-major] Adenoma / surgery. Hyperparathyroidism / surgery. Monitoring, Intraoperative. Parathyroid Hormone / blood. Parathyroid Neoplasms / surgery

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  • (PMID = 16785355.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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26. Henry JF, Sebag F: [Lateral endoscopic approach for thyroid and parathyroid surgery]. Ann Chir; 2006 Jan;131(1):51-6
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  • [Title] [Lateral endoscopic approach for thyroid and parathyroid surgery].
  • The endoscopic lateral approach in thyroid and parathyroid surgery is achieved by developing the plane between the carotid sheath laterally and the strap muscles medially.
  • The lateral approach aided by endoscopic magnification provides the surgeon with the ideal view with which to safely dissect the vital structures found in the retro-thyroid space such as the inferior thyroid artery, the recurrent laryngeal nerve and the parathyroid glands.
  • This approach was initially adopted in primary hyperparathyroidism caused by a single adenoma that had been localized preoperatively.

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  • (PMID = 16289092.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 14
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27. Tublin ME, Pryma DA, Yim JH, Ogilvie JB, Mountz JM, Bencherif B, Carty SE: Localization of parathyroid adenomas by sonography and technetium tc 99m sestamibi single-photon emission computed tomography before minimally invasive parathyroidectomy: are both studies really needed? J Ultrasound Med; 2009 Feb;28(2):183-90
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  • [Title] Localization of parathyroid adenomas by sonography and technetium tc 99m sestamibi single-photon emission computed tomography before minimally invasive parathyroidectomy: are both studies really needed?
  • OBJECTIVE: The purpose of this study was to determine the utility of radiologist-performed sonography as the principal modality for parathyroid localization before minimally invasive parathyroidectomy.
  • METHODS: Both sonography and technetium Tc 99m sestamibi single-photon emission computed tomography (SPECT) are commonly performed during imaging evaluation of patients with primary hyperparathyroidism (HPTH).
  • The sensitivity, specificity, and positive predictive value of sonography for identifying abnormal parathyroid glands were 74%, 96%, and 90%, respectively.
  • Sonography correctly localized a single adenoma or suggested multiglandular disease in 112 of 144 patients (78%).
  • Technetium 99m sestamibi SPECT correctly predicted an adenoma or multiglandular disease in 88 of 144 patients (61%).
  • Selective use of Tc 99m sestamibi in cases with negative or equivocal sonographic findings can decrease the cost of imaging before parathyroid resection considerably.
  • [MeSH-major] Minimally Invasive Surgical Procedures. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / surgery. Parathyroidectomy. Technetium Tc 99m Sestamibi. Tomography, Emission-Computed, Single-Photon / methods. Ultrasonography / methods

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  • (PMID = 19168768.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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28. Hamidi S, Hedayat A, Esfahanian F, Kamalian N: Distribution of solitary parathyroid adenoma over the parathyroid glands and its surgical management. J Coll Physicians Surg Pak; 2007 Oct;17(10):619-21
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  • [Title] Distribution of solitary parathyroid adenoma over the parathyroid glands and its surgical management.
  • OBJECTIVE: To determine the distribution of solitary parathyroid adenoma over the parathyroid glands in a group of patients with primary hyperparathyroidism Design: A case-series.
  • PATIENTS AND METHODS: A retrospective review of surgery reports of 118 patients with primary hyperparathyroidism was performed.
  • All of the patients had solitary parathyroid adenoma and the anatomical location of each adenoma was clearly defined during operation.
  • RESULTS: The distribution of adenomas over the superior and inferior parathyroid glands showed a significant higher incidence of adenoma in the lower parathyroids (p < 0.001).
  • The right to left distribution of adenomas was not significant (p=0.4).
  • CONCLUSION: Surgical exploration for primary hyperparathyroidism should be initiated from the lower parathyroid glands provided that pre-operative localization scans are not helpful.

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  • (PMID = 17999854.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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29. Suh JM, Cronan JJ, Monchik JM: Primary hyperparathyroidism: is there an increased prevalence of renal stone disease? AJR Am J Roentgenol; 2008 Sep;191(3):908-11
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  • [Title] Primary hyperparathyroidism: is there an increased prevalence of renal stone disease?
  • OBJECTIVE: Parathyroid adenomas cause hypercalcemia and are culprits in the development of renal stone disease.
  • With serum assays available, early detection of parathyroid tumors is possible.
  • We performed this retrospective review to determine whether the prevalence of nephrocalcinosis and nephrolithiasis is still increased in patients with primary hyperparathyroidism compared with those not affected by the disorder in view of the early detection of parathyroid adenomas.
  • MATERIALS AND METHODS: We retrospectively reviewed the renal sonograms of 271 patients with surgically proven primary hyperparathyroidism.
  • All patients had undergone renal imaging within 6 months before parathyroid surgery.
  • RESULTS: Nineteen (7.0%) of the 271 patients with primary hyperparathyroidism had renal stones, and eight (1.6%) of the 500 subjects in the control group had stones.
  • CONCLUSION: Our results showed a fourfold increased prevalence of asymptomatic renal stone disease in patients with surgically proven primary hyperparathyroidism compared with subjects not affected by the disorder.
  • The National Institutes of Health consensus conference on asymptomatic primary hyperparathyroidism recommended that patients with renal stone disease undergo parathyroid surgery.
  • These patients should undergo surgery even if they have minimal or no elevation of the total serum calcium value and no other metabolic manifestations of hyperparathyroidism.
  • The finding of nephrocalcinosis or nephrolithiasis is, therefore, a significant finding in evaluating patients for parathyroid surgery.
  • Routine imaging of the kidneys is necessary when primary hyperparathyroidism is documented.
  • [MeSH-major] Hyperparathyroidism / epidemiology. Hyperparathyroidism / ultrasonography. Kidney Calculi / epidemiology. Kidney Calculi / ultrasonography. Risk Assessment / methods. Ultrasonography / statistics & numerical data

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  • (PMID = 18716127.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Iglesias P, Díez JJ: Current treatments in the management of patients with primary hyperparathyroidism. Postgrad Med J; 2009 Jan;85(999):15-23
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  • [Title] Current treatments in the management of patients with primary hyperparathyroidism.
  • Primary hyperparathyroidism (PHP) develops as a consequence of autonomous hypersecretion of parathyroid hormone (PTH) by parathyroid glands usually because of a solitary parathyroid adenoma.
  • Pathological parathyroid tissue excision can be achieved by surgical and non-surgical ablative therapy.
  • Bilateral cervical surgical exploration performed by an experienced parathyroid surgeon is curative in 95-98% of PHP and is associated with a low complication rate.
  • In some patients, such as those with a single parathyroid adenoma adequately localised in presurgical imaging studies, this type of surgery may be more extensive than is needed.
  • Moreover, the introduction of new intraoperative parathyroid-localising techniques, such as intraoperative PTH measurement and nuclear mapping, has boosted the development of new and less invasive parathyroid surgical techniques.
  • Other non-surgical ablative techniques, such as selective percutaneous ethanol injection and transcatheter ablation of pathological parathyroid tissue, may be adequate in cases in which surgery is contraindicated.
  • [MeSH-major] Hyperparathyroidism, Primary / therapy

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  • (PMID = 19240283.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Receptors, Calcium-Sensing
  • [Number-of-references] 162
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31. Kirk J, Au-Yong I, Ganatra R: Multimodality imaging of a retrosternal parathyroid adenoma with multiple brown tumors. Clin Nucl Med; 2009 Sep;34(9):555-9
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  • [Title] Multimodality imaging of a retrosternal parathyroid adenoma with multiple brown tumors.
  • Brown tumors of hyperparathyroidism are rare but can mimic metastatic disease on many imaging modalities.
  • We report the case of a patient presenting with symptomatic brown tumors of hyperparathyroidism due to a large retrosternal parathyroid adenoma, with histopathological correlation of both.
  • The initial imaging findings on plain radiography, computed tomography, and bone scintigraphy were nonspecific and difficult to differentiate from the more common diagnosis of metastatic disease.
  • Whole body sestamibi imaging however demonstrated increased uptake within both the mediastinal mass and multiple bone lesions leading to the correct diagnosis.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / diagnosis. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Hyperparathyroidism / complications. Hyperparathyroidism / radiography. Hyperparathyroidism / ultrasonography. Thyroid Gland / radiography. Thyroid Gland / ultrasonography. Tomography, X-Ray Computed

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  • (PMID = 19692812.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Quint LE: Imaging of anterior mediastinal masses. Cancer Imaging; 2007;7 Spec No A:S56-62
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  • These include masses arising from the thymus, thyroid and parathyroid glands, as well as lymph nodes, pericardium, and vessels and nerves.
  • Often, the CT attenuation of the mass can be helpful in narrowing down the differential diagnosis, and attenuation values suggesting fat, water or calcium may suggest certain diagnoses; significant enhancement of the mass with intravenous contrast may also be a helpful feature.
  • Multiple types of lesions may contain calcium, including thyroid goiters and cancers, thymomas, thymic carcinomas and carcinoids, treated lymphoma, germ cell tumors, parathyroid adenomas, and lymph nodes involved with silicosis, sarcoid, tuberculosis, fungal diseases and pneumocystis.
  • Contrast enhancement may be seen in lesions of vascular origin and in vascular neoplasms, such as parathyroid adenomas and Castleman's disease.
  • [MeSH-minor] Contrast Media. Diagnosis, Differential. Humans

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  • (PMID = 17921091.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC2727971
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33. Prosst RL, Weiss J, Hupp L, Willeke F, Post S: Fluorescence-guided minimally invasive parathyroidectomy: clinical experience with a novel intraoperative detection technique for parathyroid glands. World J Surg; 2010 Sep;34(9):2217-22
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  • [Title] Fluorescence-guided minimally invasive parathyroidectomy: clinical experience with a novel intraoperative detection technique for parathyroid glands.
  • BACKGROUND: Detection of normal and pathologic parathyroid glands often is difficult due to their variability in number and location.
  • We have implemented photosensitizer-induced fluorescence for the routine intraoperative identification of parathyroids for the surgical treatment of hyperparathyroidism.
  • METHODS: From 2004 to 2007, 25 patients suffering from primary and secondary hyperparathyroidism underwent minimally invasive videoscopic-assisted parathyroidectomy after oral photosensitization with aminolevulinic acid (ALA).
  • CONCLUSIONS: Fluorescence-guided minimally invasive parathyroidectomy is technically feasible and may support the surgeon in detecting and confirming the parathyroid glands.
  • As the fluorescence method requires only moderate additional technical efforts and clinical expenditure, it is a valuable add-on component in parathyroid surgery to facilitate the operation.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods. Video-Assisted Surgery / methods
  • [MeSH-minor] Adult. Aged. Aminolevulinic Acid. Feasibility Studies. Female. Humans. Hyperparathyroidism / surgery. Intraoperative Period. Male. Middle Aged. Photosensitizing Agents. Prospective Studies. Young Adult

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  • (PMID = 20512496.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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34. Espiritu RP, Dean DS: Parathyroidectomy-induced thyroiditis. Endocr Pract; 2010 Jul-Aug;16(4):656-9
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  • RESULTS: In 2 women (84 years old and 55 years old) with no history of thyroid disease in one of them and a remote history of excision of a follicular adenoma in the other, thyrotoxicosis developed a few days to a week after parathyroidectomy for primary hyperparathyroidism.
  • The first patient underwent bilateral cervical exploration with removal of a right inferior parathyroid adenoma, whereas the second patient had excision of 3 1/2 parathyroid glands for 4-gland hyperplasia and 2 benign nodules from the left thyroid lobe.
  • [MeSH-minor] Adrenergic beta-Antagonists / therapeutic use. Aged, 80 and over. Female. Humans. Hyperparathyroidism, Primary / surgery. Middle Aged. Postoperative Period. Thyroid Function Tests. Thyrotoxicosis / blood. Thyrotoxicosis / drug therapy. Thyrotoxicosis / epidemiology. Thyrotoxicosis / etiology

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  • (PMID = 20350919.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists
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35. Zald PB, Ghaheri B, Hamilton B, Cohen J: Radiology quiz case 1. Carotid sheath parathyroid adenoma. Arch Otolaryngol Head Neck Surg; 2007 Jun;133(6):614, 616-7
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  • [Title] Radiology quiz case 1. Carotid sheath parathyroid adenoma.
  • [MeSH-major] Adenoma / diagnosis. Carotid Artery, Common / pathology. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Cricoid Cartilage / pathology. Diagnosis, Differential. Diagnostic Imaging. Female. Humans. Jugular Veins / pathology. Middle Aged

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  • (PMID = 17576915.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Kelly TG, Shattuck TM, Reyes-Mugica M, Stewart AF, Simonds WF, Udelsman R, Arnold A, Carpenter TO: Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation. J Bone Miner Res; 2006 Oct;21(10):1666-71
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  • [Title] Surveillance for early detection of aggressive parathyroid disease: carcinoma and atypical adenoma in familial isolated hyperparathyroidism associated with a germline HRPT2 mutation.
  • Familial hyperparathyroid syndromes involving mutations of HRPT2 (also CDC73), a tumor suppressor, are important to identify because the relatively high incidence of parathyroid malignancy associated with such mutations warrants a specific surveillance strategy.
  • However, there is a dearth of reports describing experience with surveillance and early detection informed by genetic insight into this disorder.
  • INTRODUCTION: Familial isolated hyperparathyroidism (FIHP) is a rare cause of parathyroid (PT) tumors without other neoplasms or endocrinopathies.
  • MATERIALS AND METHODS: A 13-year-old boy, whose father had died of PT carcinoma, developed primary hyperparathyroidism.
  • Two years later, under close biochemical surveillance, primary hyperparathyroidism recurred 5 months after documentation of normocalcemia and normal parathyroid status.
  • Ultrasound and MRI identified a newly enlarged right superior PT gland but indicated no recurrent disease in the left neck.
  • Histologic features typical of a benign adenoma were evident after surgical extirpation of the gland.
  • He was found to have a PT adenoma with aggressive features.
  • This information can be used in diagnostic and management considerations, leading to early detection and removal of potentially malignant parathyroid tumors.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma / diagnosis. Germ-Line Mutation. Hyperparathyroidism, Primary / genetics. Parathyroid Neoplasms / diagnosis. Tumor Suppressor Proteins / genetics

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  • (PMID = 16995822.001).
  • [ISSN] 0884-0431
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K24-HD01288; United States / NCRR NIH HHS / RR / M01-RR000125
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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37. Lombardi CP, Raffaelli M, De Crea C, D'Amore A, Bellantone R: Video-assisted thyroidectomy: lessons learned after more than one decade. Acta Otorhinolaryngol Ital; 2009 Dec;29(6):317-20
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  • Simultaneous video-assisted parathyroidectomy, for a parathyroid adenoma, was performed in 42 patients.

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  • (PMID = 20463836.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2868209
  • [Keywords] NOTNLM ; Endoscopic thyroidectomy / Minimally invasive thyroidectomy / Thyroidectomy
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38. Ippolito G, Palazzo FF, Sebag F, Sierra M, De Micco C, Henry JF: A single-institution 25-year review of true parathyroid cysts. Langenbecks Arch Surg; 2006 Feb;391(1):13-8
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  • [Title] A single-institution 25-year review of true parathyroid cysts.
  • BACKGROUND: Parathyroid cysts (PCs) are rare, and their origin is a subject of debate.
  • They have been described as either functional, causing hyperparathyroidism, or non-functional in eucalcaemic patients.
  • Cases of cystic degeneration of parathyroid adenomas and pseudocystic change were excluded.
  • In 27 patients, surgery was performed and all identified PCs were localized in the inferior parathyroid glands.
  • CONCLUSIONS: PCs are rare but should be included within the differential diagnosis of a neck lump.
  • [MeSH-major] Cysts / pathology. Parathyroid Diseases / pathology. Parathyroid Glands
  • [MeSH-minor] Adolescent. Aged. Biopsy, Fine-Needle. Calcium / blood. Female. Humans. Laryngoscopy. Male. Middle Aged. Parathyroid Hormone / blood. Phosphorus / blood. Reoperation. Retrospective Studies. Thyroidectomy

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  • (PMID = 16180046.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 27YLU75U4W / Phosphorus; SY7Q814VUP / Calcium
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39. Das K, Stone N, Kendall C, Fowler C, Christie-Brown J: Role of Fourier transform infrared spectroscopy (FTIR) in the diagnosis of parathyroid pathology. Photodiagnosis Photodyn Ther; 2007 Jun;4(2):124-9
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  • [Title] Role of Fourier transform infrared spectroscopy (FTIR) in the diagnosis of parathyroid pathology.
  • BACKGROUND: With the advent of minimally invasive parathyroid surgery (MIPS) accurate pathological diagnosis to differentiate parathyroid adenomas from hyperplasia has become difficult for the pathologist.
  • This is because now single glands are excised, guided by better preoperative localisation scans, while for an accurate pathological diagnosis, at least a two-gland biopsy is required.
  • Ultimately, an accurate pathological diagnosis to establish the aetiology is essential for the management of hyperparathyroidism.
  • To resolve this issue we evaluated the ability of FTIR to accurately differentiate between parathyroid adenoma and hyperplasia using their biochemical signatures.
  • Sixteen glands were analysed - eight hyperplasias and eight adenomas.
  • A multivariate statistical predictive model demonstrated the sensitivity of FTIR for adenomas to be 93% and hyperplasia 93%, (88% on cross validation testing).
  • CONCLUSIONS: Thus, infrared spectroscopy is potentially an excellent tool to differentiate the two pathologies and could be a useful adjunct to the pathological diagnosis of single glands.

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  • (PMID = 25047346.001).
  • [ISSN] 1572-1000
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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40. Randall GJ, Zald PB, Cohen JI, Hamilton BE: Contrast-enhanced MDCT characteristics of parathyroid adenomas. AJR Am J Roentgenol; 2009 Aug;193(2):W139-43
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  • [Title] Contrast-enhanced MDCT characteristics of parathyroid adenomas.
  • In this article, we describe the CT imaging characteristics of surgically confirmed adenomas and review anatomy and embryology to aid the radiologist in successfully identifying adenomas using contrast-enhanced CT.
  • CONCLUSION: Knowledge of normal CT appearance, contrast enhancement, and expected location are critical to correct interpretation of parathyroid adenoma at CT.
  • [MeSH-major] Adenoma / radiography. Choristoma / radiography. Parathyroid Neoplasms / radiography. Radiographic Image Enhancement / methods
  • [MeSH-minor] Adult. Aged, 80 and over. Contrast Media. Female. Humans. Hyperparathyroidism / etiology. Male. Neck / radiography. Pharynx / radiography. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 19620416.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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41. Ajmi S, Sfar R, Trimeche S, Ben Ali K, Nouira M: Scintigraphic findings in hungry bone syndrome following parathyroidectomy. Rev Esp Med Nucl; 2010 Mar-Apr;29(2):81-3
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  • Prolonged hypocalcemia following parathyroidectomy, called hungry bone syndrome, is a common complication of parathyroid surgery seen in 13-30% of cases.
  • In this article, we report the case of a 48-year-old woman with bone pain and multiple brown tumors as the first manifestation of primary hyperparathyroidism due to a large parathyroid adenoma.
  • [MeSH-major] Adenoma / surgery. Hypocalcemia / radionuclide imaging. Hypophosphatemia / radionuclide imaging. Osteitis Fibrosa Cystica / radionuclide imaging. Parathyroid Neoplasms / surgery. Parathyroidectomy / adverse effects
  • [MeSH-minor] Female. Femur / pathology. Femur / radionuclide imaging. Humans. Hyperparathyroidism / complications. Metacarpal Bones / pathology. Metacarpal Bones / radionuclide imaging. Middle Aged. Organophosphorus Compounds. Organotechnetium Compounds. Radiopharmaceuticals. Technetium Tc 99m Medronate. Tibia / pathology. Tibia / radionuclide imaging

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  • [Copyright] Copyright 2009 Elsevier España, S.L. y SEMNIM. All rights reserved.
  • (PMID = 19963306.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Organophosphorus Compounds; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; X89XV46R07 / Technetium Tc 99m Medronate
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42. Târcoveanu E, Moldovanu R, Georgescu S, Niculescu D, Lupaşcu C, Dimofte G: [Pancreatic endocrine tumors]. Chirurgia (Bucur); 2006 Mar-Apr;101(2):175-81
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  • In the four cases of insulinoma (all females) the diagnosis was delayed by two to five years due to misinterpretation of neurological symptoms generated by hypoglycemia.
  • The diagnosis of insulinoma was based on Whipple triad, high plasma insulin levels associated with low plasma glucose levels, as well as the symptomatic relief after intravenous glucose injection.
  • The diagnosis was confirmed on pathological examination in all cases.
  • Both patients died and diagnosis of pancreatic endocrine tumors was post-mortem.
  • The two patients with Wermer syndrome also had ulcers complicated with haemorrhage and peritonitis and parathyroid adenoma.
  • One case also had ante-hypophyseal and pituitary adenoma and the other had thyroid colloid hypertrophy.
  • [MeSH-major] Gastrinoma / diagnosis. Insulinoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Medical Records. Middle Aged. Multiple Endocrine Neoplasia Type 1 / diagnosis. Pancreatectomy. Retrospective Studies. Romania. Splenectomy. Survival Analysis. Zollinger-Ellison Syndrome / diagnosis

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  • (PMID = 16752684.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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43. Ntaios G, Savopoulos C, Chatzinikolaou A, Kaiafa G, Hatzitolios A, Karamitsos D: Parathyroid crisis as first manifestation of primary hyperparathyroidism. Eur J Intern Med; 2007 Nov;18(7):551-2
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  • [Title] Parathyroid crisis as first manifestation of primary hyperparathyroidism.
  • We report the case of a 61-year-old woman who suffered a parathyroid crisis due to a parathyroid adenoma.
  • Then, she underwent surgical excision of a newly diagnosed parathyroid adenoma.
  • Parathyroid crisis (PC), also known as parathyroid storm or acute primary hyperparathyroidism, is a rare and serious complication of primary hyperparathyroidism (PH).
  • We emphasize the importance of early diagnosis and aggressive treatment.

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  • (PMID = 17967338.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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44. Souza ER, Scrignoli JA, Bezerra FC, Ribeiro SL, Passos LF: Devastating skeletal effects of delayed diagnosis of complicated primary hyperparathyroidism because of ectopic adenoma. J Clin Rheumatol; 2008 Oct;14(5):281-4
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  • [Title] Devastating skeletal effects of delayed diagnosis of complicated primary hyperparathyroidism because of ectopic adenoma.
  • Primary hyperparathyroidism is a disease caused by exaggerated secretion of the parathyroid gland hormone, produced by an adenoma in 80% of cases.
  • Ectopic adenomas occur in a small proportion of cases.
  • Herein, the authors report a 72-year-old woman with a delayed diagnosis of primary hyperparathyroidism, produced by an intrathoracic adenoma, with a longstanding course, presenting with severe osteoporosis, multiple fractures, bone deformities, and neurologic impairments.
  • Persistent hypercalcemia, high levels of alkaline phosphatase, and parathyroid hormone were documented and a paratracheal mass was found on a helicoidal tomography of the thorax.
  • After surgical removal, the histopathological examination confirmed an ectopic adenoma of the parathyroid gland and the patient achieved some improvement in her clinical picture.
  • [MeSH-major] Adenoma / complications. Bone Diseases, Endocrine / etiology. Hyperparathyroidism, Primary / complications. Hyperparathyroidism, Primary / diagnosis. Parathyroid Neoplasms / complications
  • [MeSH-minor] Aged. Choristoma. Female. Fractures, Bone / etiology. Humans. Hypercalcemia / etiology. Nephrocalcinosis / etiology. Nephrolithiasis / etiology. Osteoporosis / etiology. Parathyroid Glands. Tracheal Diseases / etiology

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  • (PMID = 18824925.001).
  • [ISSN] 1536-7355
  • [Journal-full-title] Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • [ISO-abbreviation] J Clin Rheumatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Yonekawa H, Sugitani I, Fujimoto Y, Arai M, Yamamoto N: A family of multiple endocrine neoplasia type 2A (MEN 2A) with Cys630Tyr RET germline mutation: report of a case. Endocr J; 2007 Aug;54(4):531-5
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  • A 67-year-old woman presented a firm thyroid nodule, and preoperative examination revealed medullary thyroid carcinoma with primary hyperparthyoidism and no pheochromocytoma.
  • At surgery, bilateral medullary thyroid carcinomas and parathyroid adenoma were found.
  • Computed tomography scans and laboratory examination of blood have shown no evidence of tumor recurrence and no abnormality of parathyroid function during the 4 years after surgery.
  • This is only the second reported case with primary hyperparathyroidism.
  • RET 630 mutations might be associated with lower penetrance of primary hyperparthyoidism and pheochromocytoma.
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Adult. Aged. Child. Family Health. Female. Genotype. Humans. Hyperparathyroidism, Primary / genetics. Hyperparathyroidism, Primary / pathology. Male. Mutation, Missense. Parathyroid Neoplasms / genetics. Parathyroid Neoplasms / pathology. Pedigree. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

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  • (PMID = 17527003.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human
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46. Owens CL, Rekhtman N, Sokoll L, Ali SZ: Parathyroid hormone assay in fine-needle aspirate is useful in differentiating inadvertently sampled parathyroid tissue from thyroid lesions. Diagn Cytopathol; 2008 Apr;36(4):227-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid hormone assay in fine-needle aspirate is useful in differentiating inadvertently sampled parathyroid tissue from thyroid lesions.
  • To assess the utility of chemical analysis for parathyroid hormone in the rinse (PTH-r) obtained via fine-needle aspiration (FNA) in the setting of inadvertently sampled parathyroid tissue or lesions (PTL) during "thyroid" or "neck" FNA, the authors review their experience at a large, tertiary care academic medical center.
  • In all 10 cases with PTH-r the cytologic diagnosis was PTL or included PTL in the differential.
  • [MeSH-major] Diagnostic Errors / prevention & control. Parathyroid Glands / pathology. Parathyroid Hormone / analysis. Thyroid Gland / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Biopsy, Fine-Needle. Calcium / blood. Female. Humans. Male. Middle Aged. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / pathology. Retrospective Studies. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18335560.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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47. Urquhart AC, Wiley C: Arterial and venous parathyroid hormone levels in minimally invasive surgery. Arch Otolaryngol Head Neck Surg; 2005 Feb;131(2):137-9
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  • [Title] Arterial and venous parathyroid hormone levels in minimally invasive surgery.
  • OBJECTIVE: To establish if venous and arterial parathyroid hormone (PTH) levels are similar during minimal access parathyroid surgery.
  • PATIENTS: All patients who underwent minimally invasive parathyroid surgery over a 10-month period.
  • All patients underwent a preoperative technetium Tc 99m sestamibi scan, with 11 localizing to the site of a probable adenoma.
  • Of 13 patients undergoing both arterial and venous sampling, mean baseline venous PTH level was 221 pg/mL and 37 pg/mL at 10 minutes after excision of suspected adenoma (83% decline).
  • CONCLUSIONS: Intraoperative PTH levels during minimal access parathyroid surgery are similar for venous and arterial samples.
  • [MeSH-major] Blood Specimen Collection / methods. Parathyroid Hormone / blood. Parathyroidectomy

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  • (PMID = 15723945.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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48. Ponsky TA, Khosla A, Rothenberg SS: Experience with a new energy source for tissue fusion in pediatric patients. J Laparoendosc Adv Surg Tech A; 2009 Apr;19 Suppl 1:S207-9
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  • Other procedures included, excision of choledochal cyst (3), aortopexy, closure of bronchopleural fistula, nephrectomy(1), thymectomy (1), parathyroid adenoma excision (1), total colectomy (2), and intestinal duplication resection(2).

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  • (PMID = 18976148.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Gimm O, Juhlin C, Morales O, Persson A: Dual-energy computed tomography localizes ectopic parathyroid adenoma. J Clin Endocrinol Metab; 2010 Jul;95(7):3092-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dual-energy computed tomography localizes ectopic parathyroid adenoma.
  • [MeSH-major] Adenoma / radiography. Jugular Veins / radiography. Parathyroid Neoplasms / radiography. Tomography, X-Ray Computed. Vascular Neoplasms / radiography

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  • (PMID = 20610604.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Tang BN, Moreno-Reyes R, Blocklet D, Corvilain B, Cappello M, Delpierre I, Devuyst F, Van Simaeys G, Goldman S: Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT. Contrast Media Mol Imaging; 2008 Jul-Aug;3(4):157-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accurate pre-operative localization of pathological parathyroid glands using 11C-methionine PET/CT.
  • OBJECTIVE: The pre-operative technique most routinely used to localize pathological parathyroid glands (PPG), prior to minimal access surgery (MAS), relies on 99mTc-sestamibi (MIBI) scintigraphy.
  • DESIGN: Thirty patients were included, 22 with primary hyperparathyroidism and eight with secondary hyperparathyroidism.
  • Patients suspected of suffering from parathyroid hyperplasia underwent a complete surgical exploration of the neck region.
  • In those suspected of parathyroid adenoma, surgery was limited to the presumed localization described by MET-PET/CT.
  • The sensitivity of 11C-methionine PET/CT and MIBI scintigraphy was respectively 92% and 95% for adenoma, and 68% and 59% for hyperplasia, on the basis of available resected lesions.
  • CONCLUSION: MET-PET/CT appears a reliable technique to guide MAS of parathyroid glands.
  • [MeSH-major] Methionine. Parathyroid Glands / pathology. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods

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  • [Copyright] Copyright (c) 2008 John Wiley & Sons, Ltd.
  • (PMID = 18781582.001).
  • [ISSN] 1555-4317
  • [Journal-full-title] Contrast media & molecular imaging
  • [ISO-abbreviation] Contrast Media Mol Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbon Radioisotopes; 0 / Radiopharmaceuticals; AE28F7PNPL / Methionine
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51. Bal A, Sachdeva MU, Joshi K, Behera A, Arora S, Gupta S: Non-functioning mediastinal parathyroid adenoma with sarcoid-like granulomatous lymphadenopathy. APMIS; 2007 Jun;115(6):784-8
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  • [Title] Non-functioning mediastinal parathyroid adenoma with sarcoid-like granulomatous lymphadenopathy.
  • Non-secretory parathyroid adenomas arising in an ectopic parathyroid gland are rare.
  • We report a case of non-functioning anterior mediastinal parathyroid adenoma associated with mediastinal lymphadenopathy caused by sarcoid-like granulamatous inflammation.
  • [MeSH-major] Adenoma / pathology. Lymphatic Diseases / complications. Mediastinal Neoplasms / pathology. Parathyroid Neoplasms / pathology

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  • (PMID = 17550391.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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52. Shen HC, Rosen JE, Yang LM, Savage SA, Burns AL, Mateo CM, Agarwal SK, Chandrasekharappa SC, Spiegel AM, Collins FS, Marx SJ, Libutti SK: Parathyroid tumor development involves deregulation of homeobox genes. Endocr Relat Cancer; 2008 Mar;15(1):267-75
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  • [Title] Parathyroid tumor development involves deregulation of homeobox genes.
  • Loss of the functional second copy of the MEN1 gene causes individuals to develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and pancreas.
  • Therefore, we hypothesized that specific HOX genes were regulated by menin in parathyroid tumor development.
  • Utilizing quantitative TaqMan RT-PCR, we compared expression profiles of the 39 HOX genes in human familial MEN1 (fMEN1) parathyroid tumors and sporadic parathyroid adenomas with normal samples.
  • We identified a large set of 23 HOX genes whose deregulation is specific for fMEN1 parathyroid tumors, and only 5 HOX genes whose misexpression are specific for sporadic parathyroid tumor development.
  • These findings provide the first evidence that loss of the MEN1 tumor suppressor gene is associated with deregulation of specific HOX gene expression in the development of familial human parathyroid tumors.
  • [MeSH-major] Genes, Homeobox / genetics. Multiple Endocrine Neoplasia Type 1 / genetics. Mutation / genetics. Parathyroid Neoplasms / metabolism. Parathyroid Neoplasms / pathology. Proto-Oncogene Proteins / genetics

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  • (PMID = 18310293.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA CP010142-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MEN1 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS301793; NLM/ PMC3133970
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53. Agrawal R, Agarwal S, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK, Chand G: Primary hyperparathyroidism from parathyroid microadenoma. J Am Coll Surg; 2010 Sep;211(3):436-7; author reply 437-8
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  • [Title] Primary hyperparathyroidism from parathyroid microadenoma.
  • [MeSH-major] Adenoma / complications. Adenoma / diagnosis. Hyperparathyroidism, Primary / etiology. Parathyroid Glands / pathology. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis. Parathyroidectomy
  • [MeSH-minor] Biomarkers / blood. Biomarkers, Tumor / blood. Calcium / blood. Diagnosis, Differential. Frozen Sections. Humans. Hyperplasia / diagnosis. Parathyroid Hormone / blood. Predictive Value of Tests

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  • [CommentOn] J Am Coll Surg. 2010 Apr;210(4):456-62 [20347738.001]
  • (PMID = 20800204.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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54. Moore FD Jr: Are scintigraphy, ultrasonography, and the parathyroid hormone assay necessary to identify solitary parathyroid adenomas? Nat Clin Pract Endocrinol Metab; 2007 Mar;3(3):214-5
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  • [Title] Are scintigraphy, ultrasonography, and the parathyroid hormone assay necessary to identify solitary parathyroid adenomas?

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  • [CommentOn] Clin Endocrinol (Oxf). 2006 Jul;65(1):106-13 [16817828.001]
  • (PMID = 17262065.001).
  • [ISSN] 1745-8366
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
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55. Abboud B, Sleilaty G, Mansour E, El Ghoul R, Tohme C, Noun R, Sarkis R: Prevalence and risk factors for primary hyperparathyroidism in hyperthyroid patients. Head Neck; 2006 May;28(5):420-6
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  • [Title] Prevalence and risk factors for primary hyperparathyroidism in hyperthyroid patients.
  • BACKGROUND: Coexistence of hyperthyroidism and primary hyperparathyroidism may be more prevalent than previously recognized.
  • Eighty-three patients were initially seen for hyperthyroidism with normocalcemia (group 1), and 13 patients were initially seen for hyperthyroidism with associated primary hyperparathyroidism (group 2).
  • RESULTS: The prevalence of concomitant hyperparathyroidism was 13.5%.
  • No patients manifested hypercalcemia in the absence of organic parathyroid disease.
  • Eleven patients had a parathyroid adenoma, and two patients had parathyroid hyperplasia.
  • CONCLUSIONS: Hypercalcemia in patients with hyperthyroidism, particularly older patients, should warrant a thorough investigation for concomitant primary hyperparathyroidism that would dictate a combined thyroidectomy and parathyroidectomy.
  • [MeSH-major] Hyperparathyroidism, Primary / epidemiology. Hyperthyroidism / complications

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 16388525.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Rao V, Chaukar D, D'Cruz AK: Hypercalcemia and treated breast cancers: the diagnostic dilemma. J Cancer Res Ther; 2009 Jan-Mar;5(1):46-8
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  • However, the treating oncologist should keep in mind that a strong correlation exists between breast cancer and primary hyperparathyroidism.
  • We present a case of a patient of treated breast cancer who, in the absence of metastatic bone disease, developed hypercalcemia due to hyperparathyroidism secondary to a parathyroid adenoma.
  • [MeSH-major] Adenoma / complications. Breast Neoplasms / complications. Hypercalcemia / etiology. Neoplasms, Multiple Primary / complications. Parathyroid Neoplasms / complications
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Combined Modality Therapy. Diagnosis, Differential. Female. Heart Failure / chemically induced. Humans. Hyperparathyroidism, Primary / complications. Mastectomy. Radiotherapy

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  • (PMID = 19293490.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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57. Evans CF, Mansfield L, Sharma AK: Recurrent hyperparathyroidism caused by parathyromatosis. Hosp Med; 2005 Jul;66(7):424-5
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  • [Title] Recurrent hyperparathyroidism caused by parathyromatosis.
  • [MeSH-major] Adenoma / surgery. Hypercalcemia / etiology. Hyperparathyroidism / etiology. Parathyroid Neoplasms / surgery. Postoperative Complications / etiology

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  • (PMID = 16025803.001).
  • [ISSN] 1462-3935
  • [Journal-full-title] Hospital medicine (London, England : 1998)
  • [ISO-abbreviation] Hosp Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Clark MJ, Pellitteri PK: Assessing the impact of low baseline parathyroid hormone levels on surgical treatment of primary hyperparathyroidism. Laryngoscope; 2009 Jun;119(6):1100-5
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  • [Title] Assessing the impact of low baseline parathyroid hormone levels on surgical treatment of primary hyperparathyroidism.
  • OBJECTIVES/HYPOTHESIS: To compare patients with a parathyroid hormone index (iPTH) level less than 100 pg/mL (low baseline) with patients with an index level greater than 100 pg/mL (high baseline) relative to intraoperative iPTH levels (IOPTH), surgical findings, imaging, and outcome.
  • METHODS: : The medical records of 284 patients with primary hyperparathyroidism undergoing parathyroid exploration utilizing IOPTH were reviewed.
  • Preoperative imaging in this group appears to be less likely to yield a solitary adenoma, even in the absence of multigland disease.
  • [MeSH-major] Hyperparathyroidism, Primary / surgery. Neoplasms, Multiple Primary / surgery. Parathyroid Hormone / blood. Parathyroid Neoplasms / surgery. Parathyroidectomy

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  • (PMID = 19418534.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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59. Zillikens MC, Wijbenga A: Images in clinical medicine. Extracapsular hemorrhage from a parathyroid adenoma. N Engl J Med; 2008 Sep 11;359(11):1155
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  • [Title] Images in clinical medicine. Extracapsular hemorrhage from a parathyroid adenoma.
  • [MeSH-major] Adenoma / radiography. Hemorrhage / radiography. Parathyroid Neoplasms / radiography

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  • (PMID = 18784105.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Lange-Nolde A, Zajic T, Slawik M, Brink I, Reincke M, Moser E, Hoegerle S: PET with 18F-DOPA in the imaging of parathyroid adenoma in patients with primary hyperparathyroidism. A pilot study. Nuklearmedizin; 2006;45(5):193-6
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  • [Title] PET with 18F-DOPA in the imaging of parathyroid adenoma in patients with primary hyperparathyroidism. A pilot study.
  • Preoperative localization of parathyroid adenomas (PA) can shorten operation time and improve curative rate; it becomes especially important in minimally invasive surgical techniques.
  • PATIENTS, METHODS: Eight patients with proven primary hyperparathyroidism were studied preoperatively with PET.
  • CONCLUSION: These results suggest that PET with (18) F-DOPA is not useful in the detection of PA in patients with primary hyperparathyroidism.
  • [MeSH-major] Adenoma / radionuclide imaging. Dihydroxyphenylalanine / analogs & derivatives. Hyperparathyroidism / radionuclide imaging. Parathyroid Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 17043728.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 2C598205QX / fluorodopa F 18; 63-84-3 / Dihydroxyphenylalanine
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61. Desigan S, Syed R, Conway GS, Kurzawinski TR, Bomanji JB: Giant cervical parathyroid adenoma mimicking a sternocleidomastoid mass and presenting as a brown tumor of the mandible. Clin Nucl Med; 2007 Apr;32(4):306-8
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  • [Title] Giant cervical parathyroid adenoma mimicking a sternocleidomastoid mass and presenting as a brown tumor of the mandible.
  • [MeSH-major] Adenoma / radionuclide imaging. Giant Cell Tumor of Bone / radionuclide imaging. Head and Neck Neoplasms / radionuclide imaging. Mandibular Neoplasms / radionuclide imaging. Muscle Neoplasms / radionuclide imaging. Parathyroid Neoplasms / radionuclide imaging
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Radiopharmaceuticals. Technetium Tc 99m Sestamibi

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  • (PMID = 17413582.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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62. Thongtang N, Plengvidhaya N, Lertwattnarak R, Peepatdit T: Primary hyperparathyroidism due to cystic parathyroid adenoma: a case report. J Med Assoc Thai; 2007 Nov;90 Suppl 2:79-84
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  • [Title] Primary hyperparathyroidism due to cystic parathyroid adenoma: a case report.
  • Raw Cystic parathyroid adenoma is a rare cause of primary hyperparathyroidism.
  • The authors report one case of cystic parathyroid adenoma, who presented with progressive right hip pain for one year.
  • Parathyroid hormone level was evaluated later and was found to be high, 1,555 pg/ml (15-65 pg/ml).
  • An MRI study of the neck was done and revealed a cystic mass 38 x 36 x 40 mm in diameter just below the left lower pole of the thyroid gland.
  • Hyperfunctioning parathyroid gland was considered.
  • Parathyroidectomy was done and histopathology revealed cystic parathyroid adenoma.
  • [MeSH-major] Cystadenoma / complications. Hyperparathyroidism, Primary / etiology. Parathyroid Hormone / blood. Parathyroid Neoplasms / complications

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  • (PMID = 19230428.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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63. Lee JC, Barkdull GC, Weisman RA: Parathyroid adenoma as a cause of vocal fold paralysis. Arch Otolaryngol Head Neck Surg; 2009 Jul;135(7):712-3
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  • [Title] Parathyroid adenoma as a cause of vocal fold paralysis.
  • [MeSH-major] Adenoma / complications. Parathyroid Neoplasms / complications. Recurrent Laryngeal Nerve / pathology. Vocal Cord Paralysis / etiology

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  • (PMID = 19620594.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Akalin A, Kilincal H, Kiper H: Unusual case of calciphylaxis associated with primary hyperparathyroidism without coexistent renal failure. Endocr Pract; 2008 Apr;14(3):368-72
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  • [Title] Unusual case of calciphylaxis associated with primary hyperparathyroidism without coexistent renal failure.
  • OBJECTIVE: To report a case of calciphylaxis in a patient with primary hyperparathyroidism without coexistent renal failure.
  • Her serum calcium level was 16 mg/dL, serum phosphorus level was 2.13 mg/dL, and parathyroid hormone level was 2,257 pg/mL (reference range, 15 to 65).
  • A mass lesion was detected in the parathyroid region by both ultrasonography and a parathyroid scan.
  • The patient underwent a bilateral neck exploration, and a parathyroid adenoma measuring 3.5 by 1.5 by 1.2 cm was found on pathologic examination.
  • CONCLUSION: Severe primary hyperparathyroidism may be a factor leading to calciphylaxis, even in the absence of renal failure and a high calcium-phosphate product.
  • This potentially life-threatening condition should not be left untreated if the levels of serum calcium and parathyroid hormone are severely elevated.
  • [MeSH-major] Adenoma / complications. Calciphylaxis / etiology. Hyperparathyroidism, Primary / complications. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Renal Insufficiency / complications
  • [MeSH-minor] Calcium / blood. Female. Humans. Middle Aged. Parathyroid Hormone / blood. Prognosis

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  • (PMID = 18463046.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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65. Doshi J, Wheatley H: Pseudogout: an unusual and forgotten metabolic sequela of parathyroidectomy. Head Neck; 2008 Dec;30(12):1650-3
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  • The well-known metabolic sequela is hypocalcaemia; it may be transient or permanent depending on presence and/or activity of any residual parathyroid tissue.
  • METHODS: We present a case of a 71-year-old woman who developed pseudogout following removal of a parathyroid adenoma.
  • [MeSH-minor] Adenoma / surgery. Aged. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Female. Humans. Parathyroid Neoplasms / surgery. Suction / methods. Treatment Outcome

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18327773.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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66. Sukan A, Reyhan M, Aydin M, Yapar AF, Sert Y, Canpolat T, Aktas A: Preoperative evaluation of hyperparathyroidism: the role of dual-phase parathyroid scintigraphy and ultrasound imaging. Ann Nucl Med; 2008 Feb;22(2):123-31
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  • [Title] Preoperative evaluation of hyperparathyroidism: the role of dual-phase parathyroid scintigraphy and ultrasound imaging.
  • OBJECTIVE: The aim of this study was to evaluate the efficacy of dual-phase 99mTc-methoxyisobutylnitrile (MIBI) parathyroid scintigraphy (PS) and ultrasound (US) in primary (pHPT) and secondary (sHPT) hyperparathyroidism.
  • Preoperative serum intact parathyroid hormone (iPTH) levels, calcium (Ca), phosphate (P), alkaline phosphatase, and 24-h urinary-free Ca measurements were obtained.
  • RESULTS: Histopathology revealed 30 solitary adenomas and 71 hyperplastic glands in 55 patients.
  • The remaining patients' histopathology revealed normal parathyroid, thyroid, or lymph nodes.
  • MIBI and US identified the parathyroid pathology in 92% and 85% of patients in the non-concomitant thyroid disease group, and in 53% and 47% of patients in the concomitancy thyroid disease group, respectively.
  • The weight of the gland between primary and secondary hyperparathyroidism did not reveal a significant difference (P=0.4).
  • CONCLUSIONS: The concomitant of thyroid disease greatly influences scintigraphic and ultrasonographic detection of parathyroid pathology in pHPT and sHPT.
  • The combination of MIBI and US appears promising for localizing parathyroid pathology in patients with both primary and secondary hyperparathyroidism.
  • [MeSH-major] Hyperparathyroidism / radionuclide imaging. Technetium Tc 99m Sestamibi / pharmacokinetics
  • [MeSH-minor] Adenoma / physiopathology. Adenoma / radionuclide imaging. Adenoma / surgery. Adolescent. Adult. Aged. Calcium / blood. Diagnosis, Differential. Female. Humans. Hyperplasia / physiopathology. Hyperplasia / radionuclide imaging. Hyperplasia / surgery. Male. Middle Aged. Organ Size. Parathyroid Glands / pathology. Parathyroid Glands / radionuclide imaging. Parathyroid Glands / surgery. Parathyroid Hormone / blood. Parathyroid Neoplasms / physiopathology. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / surgery. Parathyroidectomy. Phosphates / blood. Preoperative Care. Radiopharmaceuticals / pharmacokinetics. Sensitivity and Specificity. Tomography, Emission-Computed, Single-Photon. Ultrasonography

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  • (PMID = 18311537.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Phosphates; 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi; SY7Q814VUP / Calcium
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67. Ros S, Sitges-Serra A, Pereira JA, Jimeno J, Prieto R, Sancho JJ, Pérez-Ruiz L: [Intrathyroid parathyroid adenomas: right and lower]. Cir Esp; 2008 Oct;84(4):196-200
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  • [Title] [Intrathyroid parathyroid adenomas: right and lower].
  • [Transliterated title] Adenomas paratiroideos de localización intratiroidea: derechos y bajos.
  • INTRODUCTION: Intrathyroidal parathyroid adenomas (IPA) are a not an uncommon cause of persistent hyperparathyroidism.
  • PATIENTS AND METHOD: Retrospective review of prospectively recorded surgical protocols of patients having had parathyroidectomy for primary (n = 437) or secondary (n = 137) hyperparathyroidism by the same surgeon.
  • [MeSH-major] Adenoma / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 18928769.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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68. Benhammou A, Meziane M, Dib N, Nazih N, Boulaadas M, Essakali L, Kzadri M: [Maxilla-mandibular brown tumors as a first sign of parathyroid adenoma]. Ann Otolaryngol Chir Cervicofac; 2009 Sep;126(4):216-20
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  • [Title] [Maxilla-mandibular brown tumors as a first sign of parathyroid adenoma].
  • OBJECTIVES: Through a novel observation of parathyroid adenoma revealed by brown tumors of the jaws and a review of the literature, the authors describe this rare mode of primary hyperparathyroidism discovery.
  • The etiologic search consisted of a MRI of the neck, which showed a mass behind the thyroid gland, suggesting a parathyroid adenoma.
  • The diagnosis was confirmed at surgical exploration.
  • CONCLUSION: Brown tumors are a rare mode of parathyroid adenoma discovery, and the jaw location is exceptional.
  • The diagnosis is based on the parathormone rate, and radiological exams generally find the etiology.
  • Treatment is based on surgery of the parathyroid adenoma.
  • [MeSH-major] Adenoma / diagnosis. Giant Cell Tumor of Bone / diagnosis. Hyperparathyroidism, Primary / diagnosis. Mandibular Neoplasms / diagnosis. Maxillary Neoplasms / diagnosis. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor / blood. Calcium / blood. Diagnosis, Differential. Female. Humans. Parathyroid Hormone / blood. Parathyroidectomy. Phosphorus / blood. Treatment Outcome. Young Adult

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  • (PMID = 19524874.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Parathyroid Hormone; 27YLU75U4W / Phosphorus; SY7Q814VUP / Calcium
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69. Paker I, Yilmazer D, Yandakci K, Arikok AT, Alper M: Intrathyroidal oncocytic parathyroid adenoma: a diagnostic pitfall on fine-needle aspiration. Diagn Cytopathol; 2010 Nov;38(11):833-6
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  • [Title] Intrathyroidal oncocytic parathyroid adenoma: a diagnostic pitfall on fine-needle aspiration.
  • Oncocytic parathyroid adenoma is a rarely seen benign neoplasm of the parathyroid and intrathyroidal location of this lesion is also uncommon.
  • Here, an intrathyroidal oncocytic parathyroid adenoma in a 32-year-old male is reported.
  • Frozen section examination showed intrathyroidal oncocytic parathyroid adenoma with a rim of normal parathyroid tissue.
  • The diagnosis was also confirmed with immunohistochemical stains (TTF-1, PTH, thyroglobulin) performed on permanent sections.
  • Cytopathologic features of oncocytic parathyroid adenoma and Hürthle cell thyroid neoplasm are similar.
  • It is important to keep oncocytic parathyroid adenoma in mind in the differential diagnosis of Hürthle cell thyroid neoplasm.
  • Prior knowledge of clinical, radiological and laboratory data will avoid wrong cytopathologic diagnosis.
  • [MeSH-major] Adenoma / pathology. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Thyroid Neoplasms / pathology

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  • [Copyright] © 2010 Wiley-Liss, Inc.
  • (PMID = 20301208.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Räkel A, Brossard JH, Patenaude JV, Albert C, Nassif E, Cantor T, Rousseau L, D'Amour P: Overproduction of an amino-terminal form of PTH distinct from human PTH(1-84) in a case of severe primary hyperparathyroidism: influence of medical treatment and surgery. Clin Endocrinol (Oxf); 2005 Jun;62(6):721-7
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  • [Title] Overproduction of an amino-terminal form of PTH distinct from human PTH(1-84) in a case of severe primary hyperparathyroidism: influence of medical treatment and surgery.
  • OBJECTIVE: Rare patients with severe primary hyperparathyroidism present with large parathyroid tumours, severe hypercalcaemia, very high PTH levels and osteitis fibrosa cystica.
  • Some of these patients display a large amount of C-PTH fragments in circulation and present with a higher C-PTH/I-PTH ratio than seen in less severe cases of primary hyperparathyroidism.
  • DESIGN: A 55-year-old man with severe hypercalcaemia (Ca(2+): 2.01 mmol/l), very high PTH levels (CA-PTH 82.1 and T-PTH 72 pmol/l) caused by a large parathyroid tumour (7.35 g) and accompanied by significant bone involvement (alkaline phosphatase of 185 UI/l and subperiostal bone resorption of hands) was referred to us.
  • The higher CA-PTH level relative to the T-PTH level observed before surgery in this patient was related to the oversecretion of an amino-terminal (N) form of PTH recognized by PTH assays with (1-4) or (26-32) epitopes but not by the T-PTH assay with a (12-18) epitope.
  • This molecular form represented 50% of CA-PTH measured in this patient, but only 7% in less severe cases of primary hyperparathyroidism.
  • CONCLUSION: The relationship between the overexpression of this N-PTH molecular form and severe primary hyperparathyroidism remains unclear.
  • Further studies will be required in these rare patients to see whether N-PTH is a marker of less well differentiated parathyroid tumours and/or relates to the overproduction of C-PTH fragments in the presence of severe hypercalcaemia.
  • [MeSH-major] Adenoma / blood. Hyperparathyroidism / blood. Mediastinal Neoplasms / blood. Parathyroid Hormone / blood

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  • (PMID = 15943835.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Diphosphonates; 0 / Parathyroid Hormone; 1406-16-2 / Vitamin D; OYY3447OMC / pamidronate; SY7Q814VUP / Calcium
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71. Litmathe J, Kurt M, Boeken U, Roehrborn A, Feindt P, Gams E: Combined cardiothoracic surgery and interventions of the para/thyroid gland. A rare clinical cooperation. Z Kardiol; 2005 Jan;94(1):28-32
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  • [Title] Combined cardiothoracic surgery and interventions of the para/thyroid gland. A rare clinical cooperation.
  • We investigated the question whether combined open heart surgery or thoracic surgery and interventions of the parathyreoid respectively thyroid gland may be helpful for the patients.
  • In combination with these procedures three patients underwent a subtotal goiter resection, two patients had a resection of a parathyroid adenoma and one patient underwent a right-sided hemithyroidectomy.
  • Thus we conclude that simultaneous cardiothoracic and endocrine surgery of the para-/thyroid gland can be performed with acceptable risk in cases of preoperative low-risk assessment.
  • [MeSH-major] Aortic Valve / surgery. Coronary Artery Bypass. Heart Valve Prosthesis Implantation. Hodgkin Disease / surgery. Mediastinal Neoplasms / surgery. Parathyroid Glands / surgery. Postoperative Complications / etiology. Thymectomy. Thyroidectomy


72. Bergenfelz AO, Jansson SK, Wallin GK, Mårtensson HG, Rasmussen L, Eriksson HL, Reihnér EI: Impact of modern techniques on short-term outcome after surgery for primary hyperparathyroidism: a multicenter study comprising 2,708 patients. Langenbecks Arch Surg; 2009 Sep;394(5):851-60
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  • [Title] Impact of modern techniques on short-term outcome after surgery for primary hyperparathyroidism: a multicenter study comprising 2,708 patients.
  • PURPOSE: Preoperative localization procedures and the use of intraoperative parathyroidism (iOPTH) have led to a shift of paradigm from bilateral neck exploration to focused parathyroidectomy in primary hyperparathyroidism (pHPT).
  • Histology showed parathyroid adenoma in 82%, with the median weight of 0.6 g.
  • The alleviation of hypercalcemia at the first follow-up was 93% (94% for primary operation).
  • [MeSH-major] Hyperparathyroidism, Primary / surgery. Parathyroidectomy
  • [MeSH-minor] Adenoma / diagnosis. Adolescent. Adult. Aged. Aged, 80 and over. Calcium / blood. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures. Monitoring, Intraoperative. Parathyroid Glands / diagnostic imaging. Parathyroid Hormone. Parathyroid Neoplasms / diagnosis. Radiography. Radionuclide Imaging. Treatment Outcome. Ultrasonography. Young Adult

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  • (PMID = 19618204.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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73. Prosst RL, Willeke F, Schroeter L, Post S, Gahlen J: Fluorescence-guided minimally invasive parathyroidectomy: a novel detection technique for parathyroid glands. Surg Endosc; 2006 Sep;20(9):1488-92
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  • [Title] Fluorescence-guided minimally invasive parathyroidectomy: a novel detection technique for parathyroid glands.
  • BACKGROUND: Detection of normal and pathologic parathyroid glands often is difficult because of their variability in number and location.
  • METHODS: A 72-year-old man with primary hyperparathyroidism underwent minimally invasive videoscopically assisted parathyroidectomy after photosensitization with aminolevulinic acid.
  • RESULTS: The enlarged adenoma and an atrophic parathyroid gland could be identified rapidly and removed because of their intense red fluorescence.
  • Surrounding structures such as thyroid, muscles, and soft tissue remained nonfluorescent and could easily be distinguished from the parathyroid glands.
  • CONCLUSIONS: The aminolevulinic acid-induced fluorescence technique represents a convincing visual detection method for intraoperative identification of parathyroid glands.
  • The technique serves as an additional tool requiring only moderate technical and clinical expenditure for help in guiding dissection down to a preoperatively localized adenoma.
  • [MeSH-major] Fluorescence. Hyperparathyroidism / surgery. Minimally Invasive Surgical Procedures. Parathyroid Glands / surgery. Parathyroidectomy. Surgery, Computer-Assisted
  • [MeSH-minor] Adenoma / complications. Adenoma / surgery. Aged. Aminolevulinic Acid. Atrophy. Humans. Male. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / surgery. Photosensitizing Agents

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  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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74. Alvarado R, Meyer-Rochow G, Sywak M, Delbridge L, Sidhu S: Bilateral internal jugular venous sampling for parathyroid hormone determination in patients with nonlocalizing primary hyperparathyroidism. World J Surg; 2010 Jun;34(6):1299-303
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  • [Title] Bilateral internal jugular venous sampling for parathyroid hormone determination in patients with nonlocalizing primary hyperparathyroidism.
  • BACKGROUND: Focused parathyroidectomy (FP) is offered to 60% to 70% of patients presenting to our unit with primary hyperparathyroidism (PHPT).
  • A recent report identified bilateral internal jugular venous sampling (BIJVS) as a useful tool for localization of parathyroid adenomas in patients with scan-negative PHPT.
  • RESULTS: In group A, 17 of 30 patients (56%) had lateralization of the parathyroid hormone (PTH) levels, with 11 correctly lateralizing to the side of the adenoma, 5 lateralizing despite bilateral disease, and 1 lateralizing to the contralateral side.
  • Of the remaining 13 patients in whom there was no lateralization, 3 had bilateral multigland disease, and 10 had a single parathyroid adenoma.
  • In group B, 17 of 30 patients (56%) also had lateralization of PTH levels, with 15 lateralizing to the side of the adenoma and 2 to the contralateral side.
  • The control group of patients without parathyroid disease (group C) demonstrated lateralization of PTH levels in 23 of 30 patients (76%).
  • [MeSH-major] Hyperparathyroidism, Primary / blood. Jugular Veins. Parathyroid Hormone / blood
  • [MeSH-minor] Adenoma / blood. Aged. Case-Control Studies. Female. Humans. Male. Middle Aged. Parathyroid Neoplasms / blood. Predictive Value of Tests. Prospective Studies. Radionuclide Imaging. Sensitivity and Specificity

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  • (PMID = 20372897.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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75. Yo MS, Rommes JH, Spronk PE, Janssen JC: [Lithium, a potentially dangerous drug]. Ned Tijdschr Geneeskd; 2005 Feb 5;149(6):273-6
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  • Two patients with a bipolar disorder, a woman aged 56 and a woman aged 68, who had used lithium for more than 30 years, were seen with side effects from this medication.
  • The first patient had a chronic lithium intoxication with cerebellar signs and eventually coma, diabetes insipidus, hyperthyroidism, hyperparathyroidism and psoriasis.
  • She was diagnosed with diabetes insipidus, hyperparathyroidism due to a parathyroid adenoma, hypothyroidism and a sick-sinus syndrome.
  • The adenoma was surgically removed.
  • [MeSH-minor] Adenoma / chemically induced. Aged. Bipolar Disorder / drug therapy. Coma / chemically induced. Diabetes Insipidus / chemically induced. Female. Humans. Hyperparathyroidism, Secondary / chemically induced. Hyperthyroidism / chemically induced. Hypothyroidism / chemically induced. Middle Aged. Parathyroid Neoplasms / chemically induced. Psoriasis / chemically induced. Sick Sinus Syndrome / chemically induced. Treatment Outcome

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  • [CommentIn] Ned Tijdschr Geneeskd. 2005 Jul 9;149(28):1599 [16038168.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2005 Nov 26;149(48):2700 [16358622.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2005 Apr 30;149(18):1017-8; author reply 1018-9 [15903046.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2005 Apr 30;149(18):1018; author reply 1018-9 [15903048.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2005 Apr 30;149(18):1018; author reply 1018-9 [15903047.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2005 Apr 30;149(18):1017; author reply 1018-9 [15903045.001]
  • [CommentIn] Ned Tijdschr Geneeskd. 2005 Apr 30;149(18):1019; author reply 1019 [15903049.001]
  • (PMID = 15730030.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antimanic Agents; 9FN79X2M3F / Lithium
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76. Agha A, Carpenter R, Bhattacharya S, Edmonson SJ, Carlsen E, Monson JP: Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: two case reports of an unrecognised entity. J Endocrinol Invest; 2007 Feb;30(2):145-9
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  • [Title] Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: two case reports of an unrecognised entity.
  • CONTEXT: Primary hyperparathyroidism occurs in almost all patients with the syndrome of multiple endocrine neoplasia type 1 (MEN1), but the association of MEN1 with parathyroid carcinoma has only been described previously in a single patient.
  • In this report, we describe two further cases of parathyroid carcinoma presenting in MEN1 syndrome.
  • CASE REPORTS: The first patient was a 69-yr-old woman, who presented with severe primary hyperparathyroidism and tracheal compression by a large mediastinal mass, which was shown histologically to be a parathyroid carcinoma with a second similar lesion in the neck.
  • Remarkably, she also reported primary amenorrhea and was found to have an invasive pituitary lactotroph adenoma, which was treated with cabergoline and external beam radiotherapy.
  • Neck exploration revealed two parathyroid glands only.
  • One of the parathyroid glands contained a tumor with fibrous banding, atypical mitoses, extra-capsular extension and moderate Ki 67 staining; features which are highly suggestive of carcinoma.
  • The patient's mother had primary hyperparathyroidism.
  • CONCLUSIONS: This case report describes two further patients in whom parathyroid carcinomas occurred in the context of MEN1, which gives a new insight to the possible presenting phenotype of this condition.
  • [MeSH-major] Carcinoma / diagnosis. Multiple Endocrine Neoplasia Type 1 / diagnosis. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Syndrome


77. Haglund F, Andreasson A, Nilsson IL, Höög A, Larsson C, Juhlin CC: Lack of S37A CTNNB1/β-catenin mutations in a Swedish cohort of 98 parathyroid adenomas. Clin Endocrinol (Oxf); 2010 Oct;73(4):552-3
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  • [Title] Lack of S37A CTNNB1/β-catenin mutations in a Swedish cohort of 98 parathyroid adenomas.
  • [MeSH-major] Adenoma / genetics. Mutation. Parathyroid Neoplasms / genetics. beta Catenin / genetics

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  • (PMID = 20550535.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
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78. Wirowski D, Lammers BJ, Pohl P, Schwarz K, Goretzki PE: Does multiple gland disease in primary hyperparathyroidism correlate with age or sex? Langenbecks Arch Surg; 2009 Sep;394(5):885-90
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  • [Title] Does multiple gland disease in primary hyperparathyroidism correlate with age or sex?
  • PURPOSE: Paediatric primary hyperparathyroidism (PHPT) patients suffer more often from multiple gland disease (MGD) than adults.
  • [MeSH-major] Adenoma / pathology. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / pathology

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  • (PMID = 19533167.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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79. Guthoff M, Georges G, Wehrmann M, Teichmann R, Gröne E, Risler T, Häring HU, Müssig K: [Hypercalcemic crisis due to primary hyperparathyroidism]. Dtsch Med Wochenschr; 2008 Dec;133(50):2639-43
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  • [Title] [Hypercalcemic crisis due to primary hyperparathyroidism].
  • INVESTIGATIONS: Laboratory studies showed marked hypercalcemia due to primary hyperparathyroidism and acute renal failure.
  • DIAGNOSIS, TREATMENT AND COURSE: Serum calcium levels significantly decreased after immediate rehydration, bisphosphonate administration, and continuous hemodialysis that was also indicated because of acute renal failure with anuria.
  • After knowledge of increased parathormone levels the patient underwent rapidly resection of the parathyroid adenoma which was histologically confirmed.
  • [MeSH-major] Acute Kidney Injury / complications. Adenoma / complications. Hypercalcemia / diagnosis. Hypercalcemia / etiology. Hyperparathyroidism / complications. Parathyroid Neoplasms / complications
  • [MeSH-minor] Abdominal Pain. Bone Density Conservation Agents / therapeutic use. Diagnosis, Differential. Diphosphonates / therapeutic use. Disorders of Excessive Somnolence. Female. Fluid Therapy. Humans. Middle Aged. Renal Dialysis. Tachycardia

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  • [CommentIn] Dtsch Med Wochenschr. 2009 Jan;134(5):211; author reply 212 [19180412.001]
  • (PMID = 19052999.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates
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80. Angadi PV, Rekha K, Shetty SR: "An exophytic mandibular brown tumor": an unusual presentation of primary hyperparathyroidism. Oral Maxillofac Surg; 2010 Mar;14(1):67-9
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  • [Title] "An exophytic mandibular brown tumor": an unusual presentation of primary hyperparathyroidism.
  • CASE REPORT: A case of 35-year-old male patient with previously undiagnosed primary hyperparathyroidism who presented with an atypical exophytic mandibular swelling is reported.
  • PURPOSE: The aim is to alert the clinicians to include this entity although extremely rare, in the differential diagnosis of swellings in the maxillofacial region and to highlight another remarkable aspect in the multitude of presentations associated with primary hyperparathyroidism especially in the setting of normocalcemia.
  • [MeSH-major] Adenoma / diagnosis. Hyperparathyroidism, Primary / diagnosis. Magnetic Resonance Imaging. Mandibular Diseases / diagnosis. Osteitis Fibrosa Cystica / diagnosis. Parathyroid Neoplasms / diagnosis. Radiography, Panoramic
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Mandible / pathology. Parathyroid Glands / pathology. Parathyroidectomy

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  • (PMID = 19943073.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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81. Koren I, Shpitzer T, Morgenshtern S, Shvero J: Lateral minimal parathyroidectomy: safety and cosmetic benefits. Am J Otolaryngol; 2005 Mar-Apr;26(2):83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Surgery has been the cornerstone of treatment for primary hyperparathyroidism for almost three decades.
  • The recent application of state-of-the art imaging technologies to localize hyperfunctioning adenomas preoperatively has enabled surgeons to minimize the surgical procedure, reduce total operation time and improve cosmetic results without compromising the cure rate.
  • STUDY DESIGN: Twenty-one patients with a diagnosis of primary hyperparathyroidism were selected for treatment with the lateral minimal parathyroidectomy approach following preoperative imaging with ultrasonography, Tc-sestamibi scan, or both.
  • In all cases, parathyroid adenoma was accurately localized by at least one of the imaging modalities before surgery: ultrasonography in 16 patients (76%), Tc-sestamibi scan in 15 (71%), and both in 10 (48%).
  • CONCLUSIONS: With accurate preoperative localization of unilateral parathyroid adenoma by any imaging modality and careful patient selection, lateral minimal parathyroidectomy performed by a skilled surgeon may serve as a safe, effective procedure with good clinical and aesthetic outcomes.
  • [MeSH-major] Adenoma / surgery. Cosmetic Techniques. Hyperparathyroidism / surgery. Minimally Invasive Surgical Procedures / methods. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods

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  • (PMID = 15742258.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Quarless SA, Wells CN: Bochdalek hernia, incidental finding on sestamibi parathyroid scan. Clin Nucl Med; 2005 Jun;30(6):436-9
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  • [Title] Bochdalek hernia, incidental finding on sestamibi parathyroid scan.
  • [MeSH-major] Adenoma / radionuclide imaging. Hernia, Diaphragmatic / radionuclide imaging. Hernias, Diaphragmatic, Congenital. Neoplasm Recurrence, Local / radionuclide imaging. Parathyroid Neoplasms / radionuclide imaging. Technetium Tc 99m Sestamibi

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  • (PMID = 15891305.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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83. Elliott DD, Monroe DP, Perrier ND: Parathyroid histopathology: is it of any value today? J Am Coll Surg; 2006 Nov;203(5):758-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid histopathology: is it of any value today?
  • [MeSH-major] Parathyroid Glands / pathology
  • [MeSH-minor] Adenoma / pathology. Frozen Sections. Humans. Hyperparathyroidism / pathology. Hyperplasia. Intraoperative Period. Parathyroid Neoplasms / pathology

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  • (PMID = 17084340.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Dănilă R, Andriescu L, Dăscălescu C, Lefter LP, Popovici R, Găluşcă B, Vulpoi C, Ungureanu C, Mogoş V, Dragomir C: [Differentiated thyroid cancer--peculiar morphological and clinical forms]. Rev Med Chir Soc Med Nat Iasi; 2005 Oct-Dec;109(4):746-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A review of the literature is performed in order to describe particular forms of DTC, in terms of incidence, diagnosis and treatment: occult carcinoma, carcinoma on aberrant thyroid tissue, "functional" thyroid carcinoma and familial non-medullary carcinoma.
  • A particular interest is shown to the coexistence of malignancy with benign thyroid diseases, such as goiter, hyperthyroidism and Hashimoto's thyroiditis, as well as parathyroid adenoma.
  • In conclusion, the authors emphasize that the association of carcinoma with benign thyroid conditions is not rare and it substantiate an aggressive approach in regard to diagnosis and treatment, increasing the indication for surgery and, moreover, for total thyroidectomy.

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  • (PMID = 16610171.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Romania
  • [Number-of-references] 46
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85. Wen SX, Tang PZ, Xu ZG: [Clinical characteristics of parathyroid lesions]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Oct;41(10):788-9
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  • [Title] [Clinical characteristics of parathyroid lesions].
  • [MeSH-major] Adenocarcinoma. Adenoma. Cysts. Thyroid Neoplasms

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  • (PMID = 17190433.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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86. Tanaka Y: Primary hyperparathyroidism with breast carcinoma. Breast Cancer; 2010 Oct;17(4):265-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism with breast carcinoma.
  • BACKGROUND: Although hypercalcemia is a common complication of breast carcinoma (BC), it may be due to primary hyperparathyroidism (pHPT), which has a similar sex or age predilection to that of BC.
  • METHOD: To investigate coexistent pHPT in BC patients, the medical records of persons who had undergone surgery for primary BC without bone metastases between October 2004 and March 2008 at the Tsuchiura Kyodo General Hospital were retrospectively reviewed.
  • In all five patients, the parathyroids were pathologically diagnosed to have adenoma.
  • CONCLUSION: Primary hyperparathyroidism was diagnosed in 2.88% of the BC patients, which was more than expected, in comparison to the incidence of pHPT in adult women, which is 0.04-0.08%.
  • [MeSH-major] Adenoma / complications. Breast Neoplasms / complications. Hypercalcemia / etiology. Hyperparathyroidism / complications. Parathyroid Neoplasms / complications
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Parathyroid Hormone / blood. Parathyroid Hormone-Related Protein / blood. Retrospective Studies

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  • (PMID = 19657710.001).
  • [ISSN] 1880-4233
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Parathyroid Hormone-Related Protein
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87. Uruno T, Kebebew E: How to localize parathyroid tumors in primary hyperparathyroidism? J Endocrinol Invest; 2006 Oct;29(9):840-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How to localize parathyroid tumors in primary hyperparathyroidism?
  • The management of primary hyperparathyroidism (PHPT) has dramatically changed in the last 5 yr.
  • This change has taken place because of the improved accuracy of pre-operative localizing studies in selecting patients who have single-gland parathyroid disease (single adenoma) and can therefore have a minimally invasive parathyroidectomy.
  • Sestamibi scanning followed by ultrasound, magnetic resonance imaging (MRI) and computed tomography (CT) scans are most accurate for localizing parathyroid tumors in patients with PHPT.
  • The routine use of one or more localizing studies commonly identifies the parathyroid tumor in patients with single-gland disease; but if localizing studies are negative or discordant, patients should have intra-operative PTH levels monitored or have a bilateral neck exploration to ensure a high rate of biochemical cure.
  • [MeSH-major] Adenoma / complications. Adenoma / diagnosis. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis

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  • (PMID = 17114918.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 47
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88. Hamidi S, Soltani A, Hedayat A, Kamalian N: Primary hyperparathyroidism: a review of 177 cases. Med Sci Monit; 2006 Feb;12(2):CR86-9
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  • [Title] Primary hyperparathyroidism: a review of 177 cases.
  • BACKGROUND: We designed a comprehensive study to explore different aspects of primary hyperparathyroidism in a series of Iranian patients.
  • MATERIAL/METHODS: In a retrospective study from 1981 to 2003, we reviewed records of 177 patients operated on with the diagnosis of primary hyperparathyroidism in Shariati Hospital.
  • Patients with secondary or tertiary hyperparathyroidism and those being re-operated were excluded.
  • RESULTS: 88.1% of the lesions were adenoma, 9.6% hyperplasia, and 1 case proved to be carcinoma.
  • In 1.7% of patients, no pathologic gland(s) were found.
  • Patients with hyperplasia had lower calcium levels than patients with adenoma 24 hours post-operation, with mean calcium levels of 8.1+/-1.2 mg/dl versus 9.03+/-1.2 mg/dl, respectively (p=0.02).
  • Mean weight of adenomas was 4.1 gram (range 0.8-25 g).
  • Adenomas were mostly (74%) located in lower parathyroid glands and 6.3% of them were ectopic.
  • CONCLUSIONS: Primary hyperparathyroidism should be expected at younger ages in Iran.
  • Parathyroid hyperplasia in a patient should alert the surgeon of the higher risk of postoperative hypocalcemia.
  • [MeSH-major] Hyperparathyroidism, Primary / diagnosis
  • [MeSH-minor] Adenoma / pathology. Adolescent. Adult. Aged. Calcium / blood. Carcinoma / pathology. Female. Humans. Hyperplasia. Iran. Male. Middle Aged. Parathyroid Neoplasms / pathology. Retrospective Studies

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  • (PMID = 16449953.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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89. Kawata T, Imanishi Y, Kobayashi K, Onoda N, Takemoto Y, Tahara H, Okuno S, Ishimura E, Miki T, Ishikawa T, Inaba M, Nishizawa Y: Direct in vitro evidence of extracellular Ca2+-induced amino-terminal truncation of human parathyroid hormone (1-84) by human parathyroid cells. J Clin Endocrinol Metab; 2005 Oct;90(10):5774-8
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  • [Title] Direct in vitro evidence of extracellular Ca2+-induced amino-terminal truncation of human parathyroid hormone (1-84) by human parathyroid cells.
  • CONTEXT: Although serum calcium (Ca2+) concentration regulates the generation of amino-terminally (N-terminally) truncated forms of human PTH (hPTH) degraded from (1-84)hPTH, no studies have yet reported whether the parathyroid gland itself is responsible for this process.
  • OBJECTIVE: Our objective was to determine the site of N-terminal truncation and its roles in PTH metabolism in parathyroid cells in vitro.
  • METHODS: The effect of extracellular Ca2+ concentration was examined on N-terminal truncation in primary cultured parathyroid cells.
  • The parathyroid glands were obtained from the patients with primary and uremia-associated secondary hyperparathyroidisms who underwent therapeutic parathyroidectomies.
  • Suppression of PTH secretion by increasing the extracellular Ca2+ concentration was more evident with the Bio-PTH assay than with the I-PTH assay for both cultured parathyroid cells prepared from parathyroid adenomas and uremia-associated secondary hyperparathyroidism.
  • CONCLUSIONS: These findings suggest that the N-terminal truncation is regulated by extracellular Ca2+ concentration and works to suppress the generation of (1-84)hPTH in parathyroid cells.
  • [MeSH-major] Calcium / pharmacology. Parathyroid Glands / drug effects. Parathyroid Glands / metabolism. Parathyroid Hormone / metabolism
  • [MeSH-minor] Cells, Cultured. Chromatography, High Pressure Liquid. Humans. Hyperparathyroidism, Secondary / metabolism. Peptide Fragments / chemistry. Peptide Fragments / isolation & purification. Uremia / complications

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  • (PMID = 16046589.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Peptide Fragments; SY7Q814VUP / Calcium
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90. Santamaría I, Alvarez-Hernández D, Jofré R, Polo JR, Menárguez J, Cannata-Andía JB: Progression of secondary hyperparathyroidism involves deregulation of genes related to DNA and RNA stability. Kidney Int; 2005 Jun;67(6):2267-79
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  • [Title] Progression of secondary hyperparathyroidism involves deregulation of genes related to DNA and RNA stability.
  • BACKGROUND: Renal secondary hyperparathyroidism in its late stages becomes autonomous, so excessive parathyroid hormone (PTH) secretion no longer responds to physiologic stimuli or to aggressive medical treatment.
  • METHODS: To gain molecular understanding of progression of renal secondary hyperparathyroidism, normal and hyperplastic parathyroid tissue with diffuse and nodular growth were analyzed.
  • The results were also compared to parathyroid adenomas.
  • CONCLUSION: According to the function described for the deregulated genes, when secondary hyperparathyroidism becomes autonomous and refractory to treatment, RNA degradation may be increased while DNA integrity may be compromised.
  • These two mechanisms, combined with deregulation of genes related to growth and differentiation show the complex pathway of parathyroid glands' evolution in renal hyperparathyroidism and may explain the large amount of molecular cytogenetic aberrations found in refractory hyperparathyroidism.
  • Considering that some of the genes with altered expression in nodular hyperplasia lead to irreversible consequences in the genomic integrity of the cells, an adequate and early management of the secondary hyperparathyroidism of chronic kidney disease becomes mandatory.
  • [MeSH-major] DNA / metabolism. Gene Expression Profiling. Hyperparathyroidism, Secondary / genetics. RNA Stability
  • [MeSH-minor] Adult. Aged. Apoptosis. Cell Proliferation. Child. Cluster Analysis. Disease Progression. Female. Genomic Instability. Humans. Hyperplasia. Male. Middle Aged. Parathyroid Glands / pathology. Receptors, Calcitriol / genetics. Receptors, Calcium-Sensing / genetics


91. Balasanthiran A, Sandler B, Amonoo-Kuofi K, Swamy R, Kaniyur S, Kaplan F: Sarcoid granulomas in the parathyroid gland - a case of dual pathology: hypercalcaemia due to a parathyroid adenoma and coexistent sarcoidosis with granulomas located within the parathyroid adenoma and thyroid gland. Endocr J; 2010;57(7):603-7
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  • [Title] Sarcoid granulomas in the parathyroid gland - a case of dual pathology: hypercalcaemia due to a parathyroid adenoma and coexistent sarcoidosis with granulomas located within the parathyroid adenoma and thyroid gland.
  • We present a highly unusual and interesting case of coexistent hyperparathyroidism and sarcoidosis leading to hypercalcaemia.
  • Parathyroid imaging was then requested and an adenoma was identified.
  • Surprisingly, surgery revealed the coexistence of a parathyroid adenoma with the unexpected finding of sarcoid granulomas within the parathyroid and thyroid glands.
  • [MeSH-major] Adenoma / complications. Granuloma / complications. Hypercalcemia / etiology. Parathyroid Diseases / complications. Parathyroid Neoplasms / complications. Sarcoidosis / complications. Thyroid Neoplasms / complications
  • [MeSH-minor] Aged. Female. Humans. Neoplasms, Multiple Primary / complications. Neoplasms, Multiple Primary / surgery. Parathyroid Glands / pathology. Parathyroid Glands / surgery. Parathyroidectomy. Thyroid Gland / pathology


92. Richards ML, Grant CS: Current applications of the intraoperative parathyroid hormone assay in parathyroid surgery. Am Surg; 2007 Apr;73(4):311-7
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  • [Title] Current applications of the intraoperative parathyroid hormone assay in parathyroid surgery.
  • Parathyroid hormone measurement using a two-site immunochemiluminometric assay has allowed for a rapid and accurate technique that has found its way into the operative armamentarium of some parathyroid surgeons.
  • It can be used to assess the completeness of parathyroid gland resection and allow for a minimally invasive parathyroidectomy.
  • The purpose of this review is to provide the surgeon with the practical points and pitfalls of the use of intraoperative parathyroid hormone in the treatment of parathyroid disease.
  • [MeSH-major] Luminescent Measurements / methods. Monitoring, Intraoperative / methods. Parathyroid Hormone / blood. Parathyroidectomy
  • [MeSH-minor] Adenoma / blood. Adenoma / surgery. Humans. Hyperparathyroidism / blood. Hyperparathyroidism / genetics. Hyperparathyroidism / surgery. Hyperparathyroidism, Secondary / blood. Hyperparathyroidism, Secondary / surgery. Minimally Invasive Surgical Procedures. Multiple Endocrine Neoplasia / blood. Multiple Endocrine Neoplasia / surgery. Parathyroid Neoplasms / blood. Parathyroid Neoplasms / surgery. Reoperation

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  • (PMID = 17439020.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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93. Cetani F, Ambrogini E, Viacava P, Pardi E, Fanelli G, Naccarato AG, Borsari S, Lemmi M, Berti P, Miccoli P, Pinchera A, Marcocci C: Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma? Eur J Endocrinol; 2007 May;156(5):547-54
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  • [Title] Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?
  • OBJECTIVE: HRPT2 gene mutations are associated with parathyroid carcinomas, and absence of parafibromin immunoreactivity has been suggested as a diagnostic marker of malignancy.
  • The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results of immunohistochemistry with those of HRPT2 analysis.
  • DESIGN AND PATIENTS: We performed parafibromin and cyclin D1 immunostaining and HRPT2 gene analysis using loss of heterozygosity studies and sequencing analysis in parathyroid specimens from 11 patients with carcinoma (eleven primary tumors, one skin, and four lung metastases), 22 with sporadic adenomas, and 4 with atypical adenomas.
  • RESULTS: Ten out of eleven parathyroid cancers were negative for parafibromin staining and showed HRPT2 gene abnormalities.
  • All but one sporadic adenomas showed parafibromin immunoreactivity and no HRPT2 gene abnormalities.
  • Two atypical adenomas were positive and two negative with parafibromin staining.
  • CONCLUSIONS: We have shown that negative parafibromin staining is almost invariably associated with HRPT2 mutations and confirm that loss of parafibromin staining strongly predicts parathyroid malignancy.
  • In clinical practice, these tests could be particularly useful in the subset of parathyroid tumors with equivocal histological examination.

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  • (PMID = 17468190.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CDC73 protein, human; 0 / DNA, Neoplasm; 0 / Tumor Suppressor Proteins; 136601-57-5 / Cyclin D1
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94. Haddad FH, Malkawi OM, Sharbaji AA, Jbara IF, Rihani HR: Primary hyperparathyroidism. A rare cause of spinal cord compression. Saudi Med J; 2007 May;28(5):783-6
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  • [Title] Primary hyperparathyroidism. A rare cause of spinal cord compression.
  • Investigations revealed high parathyroid hormone 1152 ng/dl, calcium 10.9 mg/dl, and low phosphorus of 2.4 mg/dl after stopping calcium supplement.
  • A neck ultrasound and SESTA MIBI parathyroid scan confirmed a right lower parathyroid adenoma.
  • Two weeks later the patient underwent right parathyroidectomy that proved to be a parathyroid adenoma.
  • [MeSH-major] Hyperparathyroidism, Primary / complications. Spinal Cord Compression / etiology
  • [MeSH-minor] Adenoma / complications. Female. Humans. Middle Aged. Parathyroid Neoplasms / complications

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  • (PMID = 17457452.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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95. Anaforoğlu I, Siviloğlu C, Livaoğlu A, Algün E: Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report. J Med Case Rep; 2010;4:400
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  • [Title] Granulomatous infiltration of a parathyroid adenoma presenting as primary hyperparathyroidism in a woman: a case report.
  • INTRODUCTION: Hypercalcemia can be associated with vitamin D (1,25(OH)2D3) -mediated granulomatous disorders in addition to primary hyperparathyroidism (PHPT).
  • There are many reports about co-presentation of a parathyroid adenoma and a granulomatous disorder in the literature.
  • However, granulomatous inflammation within a parathyroid adenoma is very rare.
  • She underwent excision of an enlarged right inferior parathyroid gland.
  • Histopathological analysis revealed features of a parathyroid adenoma with foci of epithelioid non-caseating granulomas.
  • CONCLUSION: Granulomatous infiltration of a parathyroid adenoma is a rare condition.
  • Pathological examination of the excised adenoma is the only way to diagnose the underlying occult granulomatous disorder.
  • Clinicians should also consider persistent hypercalcemia to be a possible indicator of concomitant parathyroid adenoma.

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  • (PMID = 21143903.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3019160
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96. Pang T, Stalberg P, Sidhu S, Sywak M, Wilkinson M, Reeve TS, Delbridge L: Minimally invasive parathyroidectomy using the lateral focused mini-incision technique without intraoperative parathyroid hormone monitoring. Br J Surg; 2007 Mar;94(3):315-9
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  • [Title] Minimally invasive parathyroidectomy using the lateral focused mini-incision technique without intraoperative parathyroid hormone monitoring.
  • BACKGROUND: Minimally invasive parathyroidectomy (MIP) involves scan-directed removal of a single adenoma through a 2.0-cm mini-incision without intraoperative monitoring.
  • Levels of parathyroid hormone (PTH) were measured after operation solely to aid informed discharge.
  • [MeSH-major] Adenoma / surgery. Hyperparathyroidism, Primary / surgery. Parathyroid Hormone / metabolism. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods

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  • [Copyright] (c) 2007 British Journal of Surgery Society Ltd.
  • (PMID = 17205496.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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97. Ansquer C, Mirallié E, Carlier T, Abbey-Huguenin H, Aubron F, Kraeber-Bodéré F: Preoperative localization of parathyroid lesions. Value of 99mTc-MIBI tomography and factors influencing detection. Nuklearmedizin; 2008;47(4):158-62
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  • [Title] Preoperative localization of parathyroid lesions. Value of 99mTc-MIBI tomography and factors influencing detection.
  • The AIM of our study was to assess retrospectively the value of (99m)Tc-MIBI SPECT in the localization of parathyroid lesions in primary hyperparathyroidism and to determine the impact of PTH level, age, sex, characteristics of the lesions and thyroid nodules on the sensitivity of imaging.
  • PATIENTS, METHODS: Fifty nine patients who were cured after the resection of 60 lesions (50 adenomas, 9 hyperplasias and 1 carcinoma, 9 of them in ectopy) were selected. (99m)TcO(4)(-), early and late (99m)Tc-MIBI planar images (n = 59), (99m)Tc-MIBI SPECT (n = 58) and ultrasound (n = 50) performed preoperatively were analyzed.
  • Ultrasound (US) had the lowest sensitivity (56%) and the highest rate of false-positive results (n = 10), but identified 2 adenomas which were not detected by scintigraphy.
  • Better sensitivities were observed when age <69 years, preoperative PTH level > or =155 pg/ml, weight of the gland > or =0.80 g and in the absence of thyroid nodules.
  • CONCLUSION: Combination of US, double-phase (99m)Tc-MIBI/(99m)TcO(4)(-) planar scintigraphy and SPECT is the most accurate method for the detection of parathyroid lesions and should be performed before minimally invasive surgery, especially when PTH level is low, in older patients and in cases of multinodular goiter.
  • [MeSH-major] Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / surgery. Technetium Tc 99m Sestamibi
  • [MeSH-minor] Adenoma / radionuclide imaging. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Organ Size. Parathyroid Glands / radionuclide imaging. Radiopharmaceuticals / pharmacokinetics. Thyroid Gland / radionuclide imaging

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  • (PMID = 18690375.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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98. Balogh K, Hunyady L, Patocs A, Gergics P, Valkusz Z, Toth M, Racz K: MEN1 gene mutations in Hungarian patients with multiple endocrine neoplasia type 1. Clin Endocrinol (Oxf); 2007 Nov;67(5):727-34
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  • OBJECTIVE: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder associated with mutations of the MEN1 gene.
  • MEN1 may present as a familial or a sporadic disorder, with multiple endocrine tumours including parathyroid adenomas or hyperplasias, and pancreatic endocrine and pituitary gland tumours.
  • Of the 13 index patients with a MEN1-related state, only one patient with recurrent isolated primary hyperparathyroidism had a MEN1 gene mutation.


99. Rasmuson T, Tavelin B: Risk of parathyroid adenomas in patients with thyrotoxicosis exposed to radioactive iodine. Acta Oncol; 2006;45(8):1059-61
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  • [Title] Risk of parathyroid adenomas in patients with thyrotoxicosis exposed to radioactive iodine.
  • External ionizing radiation is a risk factor for primary hyperparathyroidism.
  • Whether exposure to radioactive iodine contributes to the risk of primary hyperparathyroidism is unknown.
  • Patients with thyrotoxicosis are often treated with radioactive iodine and its accumulation in the thyroid gland exposes the adjacent parathyroid glands to radioactivity.
  • Patients with parathyroid adenomas (ICD-9 = 195.1) were recruited from the Swedish Cancer Registry.
  • Eleven patients with parathyroid adenomas following the diagnosis of thyrotoxicosis were identified.
  • The median age at exposure was 59 years and the latency period between diagnosis of thyrotoxicosis and parathyroid adenoma was 7.4 years (range <1-19 years).
  • This study does not indicate that patients with thyrotoxicosis treated with radioactive iodine in adult age have increased risk of developing parathyroid adenoma.
  • [MeSH-major] Adenoma / etiology. Iodine Radioisotopes / adverse effects. Parathyroid Neoplasms / etiology. Thyrotoxicosis / radiotherapy

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  • (PMID = 17118839.001).
  • [ISSN] 0284-186X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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100. Oztürk M, Ustek D, Akbas F, Kösem M, Abaci N, Alagöl F, Oztürk G, Kotan C: The presence of erythropoietin receptor in parathyroid cells. J Endocrinol Invest; 2007 Dec;30(11):RC35-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The presence of erythropoietin receptor in parathyroid cells.
  • CONTEXT: Effects of erythropoietin on parathyroid cell function has not been studied before.
  • OBJECTIVE: We aimed to demonstrate whether erythropoietin receptor present in parathyroid cells.
  • DESIGN: The specimens of normal parathyroid gland, parathyroid adenoma and hyperplasia were retrieved from our pathology archives.
  • Its density was higher in normal parathyroid, followed by parathyroid adenoma and hyperplasia.
  • CONCLUSION: Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia.
  • [MeSH-major] Adenoma / metabolism. Parathyroid Glands / metabolism. Parathyroid Neoplasms / metabolism. Receptors, Erythropoietin / metabolism

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  • (PMID = 18250608.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Receptors, Erythropoietin; 11096-26-7 / Erythropoietin
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