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1. Matsuo SE, Fiore AP, Siguematu SM, Ebina KN, Friguglietti CU, Ferro MC, Kulcsar MA, Kimura ET: Expression of SMAD proteins, TGF-beta/activin signaling mediators, in human thyroid tissues. Arq Bras Endocrinol Metabol; 2010 Jun;54(4):406-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: The protein expression of SMADs was evaluated in multinodular goiter, follicular adenoma, papillary and follicular carcinomas by immunohistochemistry.
  • RESULTS: The expression of pSMAD2/3, SMAD4 and SMAD7 was observed in both benign and malignant thyroid tumors.
  • Although pSMAD2/3, SMAD4 and SMAD7 exhibited high cytoplasmic staining in carcinomas, the nuclear staining of pSMAD2/3 was not different between benign and malignant lesions.
  • [MeSH-minor] Adenoma / metabolism. Carcinoma, Papillary, Follicular / metabolism. Goiter, Nodular / metabolism. Humans. Signal Transduction / physiology. Smad2 Protein / analysis. Smad3 Protein / analysis. Smad4 Protein / analysis. Smad7 Protein / analysis

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  • (PMID = 20625653.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / SMAD2 protein, human; 0 / SMAD3 protein, human; 0 / SMAD4 protein, human; 0 / SMAD7 protein, human; 0 / Smad Proteins, Receptor-Regulated; 0 / Smad2 Protein; 0 / Smad3 Protein; 0 / Smad4 Protein; 0 / Smad7 Protein; 0 / Transforming Growth Factor beta; 104625-48-1 / Activins
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2. Denning KM, Smyth PC, Cahill SF, Finn SP, Conlon E, Li J, Flavin RJ, Aherne ST, Guenther SM, Ferlinz A, O'Leary JJ, Sheils OM: A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples. Mod Pathol; 2007 Oct;20(10):1095-102
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  • [Title] A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
  • Follicular variant of papillary thyroid carcinoma is a lesion that frequently causes difficulties from a diagnostic perspective in the laboratory.
  • The purpose of this study was to interrogate a cohort of archival thyroid lesions using gene expression analysis of a panel of markers proposed to have utility as adjunctive markers in the diagnosis of thyroid neoplasia and follicular variant of papillary thyroid carcinoma in particular.
  • HLA-DMA, HLA-DQB1, MT1X, CSNK1G2 and RAB23 were found to be differentially expressed (P<0.05) when comparing follicular adenoma and follicular variant of papillary thyroid carcinoma.
  • Comparison of follicular adenoma and follicular thyroid carcinoma groups showed significant differential expression for MT1K, MT1X and RAB23 (P<0.05).
  • Comparison of the papillary thyroid carcinoma group (classic and follicular variants) and the follicular adenoma group showed differential expression for CSNK1G2, HLA-DQB1, MT1X and RAB23 (P<0.05).
  • Finally, KRAS2 was found to be differentially expressed (P<0.05) when comparing the papillary thyroid carcinoma and follicular thyroid carcinoma groups.
  • This panel of molecular targets discriminates between follicular adenoma, papillary thyroid carcinoma, follicular variant of papillary thyroid carcinoma and follicular thyroid carcinoma by their expression repertoires.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary, Follicular / genetics. Gene Expression. Reverse Transcriptase Polymerase Chain Reaction / methods. Thyroid Neoplasms / genetics

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  • (PMID = 17660800.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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3. Gerhard R, Nonogaki S, Fregnani JH, Soares FA, Nagai MA: NDRG1 protein overexpression in malignant thyroid neoplasms. Clinics (Sao Paulo); 2010 Jun;65(8):757-62
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  • OBJECTIVES: The aim of this study was to examine the expression of the N-myc downstream-regulated gene 1 protein in benign and malignant lesions of the thyroid gland by immunohistochemistry.
  • METHODS: A tissue microarray paraffin block containing 265 tissue fragments corresponding to normal thyroid, nodular goiter, follicular adenoma, papillary thyroid carcinoma (classical pattern and follicular variant), follicular carcinoma, and metastases of papillary and follicular thyroid carcinomas were analyzed by immunohistochemistry using a polyclonal anti- N-myc downstream-regulated gene 1 antibody.
  • RESULTS: The immunohistochemical expression of N-myc downstream-regulated gene 1 was higher in carcinomas compared to normal thyroid glands and nodular goiters, with higher expression in classical papillary thyroid carcinomas and metastases of thyroid carcinomas (P < 0.001).
  • A combined analysis showed higher immunohistochemical expression of NDRG1 in malignant lesions (classical pattern and follicular variant of papillary thyroid carcinomas, follicular carcinomas, and metastases of thyroid carcinomas) compared to benign thyroid lesions (goiter and follicular adenomas) (P = 0.043).
  • CONCLUSIONS: Thyroid carcinomas showed increased immunohistochemical N-myc downstream-regulated gene 1 expression compared to normal and benign thyroid lesions and is correlated with more advanced tumor stages.
  • [MeSH-major] Adenoma / metabolism. Cell Cycle Proteins / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Neoplasm Proteins / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 20835551.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / N-myc downstream-regulated gene 1 protein; 0 / Neoplasm Proteins; Thyroid cancer, papillary
  • [Other-IDs] NLM/ PMC2933120
  • [Keywords] NOTNLM ; Immunohistochemistry / NDRG1 / Thyroid Carcinoma / Thyroid Gland / Tissue Microarray
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4. Aparajita R, Gomez D, Verbeke CS, Menon KV: Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum. JOP; 2008;9(2):212-5
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  • [Title] Papillary adenoma of the distal common bile duct associated with a synchronous carcinoma of the peri-ampullary duodenum.
  • CONTEXT: Benign tumours of the biliary tract are an extremely rare group of neoplasms.
  • Coincidence of a biliary adenoma of the distal common bile duct and a synchronous adenocarcinoma of the peri-ampullary duodenum has never been reported in the literature.
  • CASE REPORT: We report a case of a papillary adenoma in the common bile duct in a 75-year-old female, who had synchronous invasive adenocarcinoma of the peri-ampullary duodenum.
  • CONCLUSION: Isolated papillary adenoma of the bile duct is extremely rare, and in this unusual case it coincided with a peri-ampullary duodenal adenocarcinoma.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Common Bile Duct / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 18326932.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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5. Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO: Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract; 2009 Jul-Aug;15(5):463-8
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  • [Title] Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism.
  • OBJECTIVE: To describe a patient presenting with the rare constellation of synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma.
  • He was found to have a 3.4-cm parathyroid carcinoma on the left side and a 3.2-cm papillary carcinoma in the right thyroid lobe.
  • In addition, a 917-mg parathyroid adenoma was found on the right side.
  • To our knowledge, our patient is the first documented case with a parathyroid adenoma in addition to synchronous parathyroid and thyroid carcinomas.
  • The presence of concurrent parathyroid carcinoma and parathyroid adenoma can cause diagnostic confusion and should be considered in patients presenting with severe hyperparathyroidism.

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  • (PMID = 19491068.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] ENG
  • [Grant] United States / NINR NIH HHS / NR / NR008545-06; United States / NINR NIH HHS / NR / R56 NR008545; United States / NINR NIH HHS / NR / R56 NR008545-06
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS217054; NLM/ PMC2917245
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6. Chang MC, Tsai SC, Lin WY: Dual-phase 99mTc-MIBI parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report. Kaohsiung J Med Sci; 2008 Oct;24(10):542-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dual-phase 99mTc-MIBI parathyroid imaging reveals synchronous parathyroid adenoma and papillary thyroid carcinoma: a case report.
  • Here, we present a case of a 49-year-old woman with a parathyroid adenoma coexisting with two sites of papillary thyroid carcinoma.
  • Dual-phase 99mTc-methoxyisobutylisonitrile (MIBI) parathyroid imaging before the operation correctly visualized the site of the parathyroid adenoma.
  • In addition, two papillary thyroid carcinomas showed faint uptake of 99mTc-MIBI on delayed image.
  • Total thyroidectomy and parathyroidectomy of a solitary parathyroid adenoma were performed.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parathyroid Neoplasms / diagnosis. Technetium Tc 99m Sestamibi. Thyroid Neoplasms / diagnosis

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  • (PMID = 19181586.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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7. Demirag F, Cakir E, Aydin E, Kaya S, Akyurek N: Ectopic primary B cell lymphoma of the thyroid presenting as an anterior mediastinal mass. A case report. Acta Chir Belg; 2009 Nov-Dec;109(6):802-4
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  • Follicular adenoma, papillary carcinoma and follicular carcinoma in the mediastinum has been reported, but primary ectopic thyroid B cell lymphoma has not been reported previously.

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  • (PMID = 20184075.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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8. Clerici T, Kolb W, Beutner U, Bareck E, Dotzenrath C, Kull C, Niederle B, German Association of Endocrine Surgeons: Diagnosis and treatment of small follicular thyroid carcinomas. Br J Surg; 2010 Jun;97(6):839-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most initial diagnoses had to be revised because of incorrect size assessment or incorrect diagnosis (benign adenoma, papillary thyroid carcinoma (PTC), follicular variant of PTC).

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  • (PMID = 20473996.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Investigator] Kaserer K; Perren A; Schmid KW; Köberle-Wührer R; Wenzl E; Asari R; Klinge U; Müller G; Kroell KP; Blankenburg C; Voss H; Cupisti K; Witte J; Knoefel WT; Simon D; Lienenlüke RH; Vorländer C; Wacha H; Schabram J; Lorenz K; Dralle H; Wojciechowski B; Kussmann J; Weber Y; Schürmann G; Goretzki PE; Ulitzer H; Eberle A; Mayer M; Stabenow R; Stegmaier C; Bühlmann R; Schlumpf R; Triponez F; Ess SM
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9. Letsas KP, Vartholomatos G, Tsepi C, Tsatsoulis A, Frangou-Lazaridis M: Fine-needle aspiration biopsy-RT-PCR expression analysis of prothymosin alpha and parathymosin in thyroid: novel proliferation markers? Neoplasma; 2007;54(1):57-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration biopsy-RT-PCR expression analysis of prothymosin alpha and parathymosin in thyroid: novel proliferation markers?
  • Genetic analysis of the aspirates by RT-PCR may contribute, in parallel to the cytology report, to a more precise diagnosis.
  • A semi-quantitative RT-PCR assay was developed to determine prothymosin alpha and parathymosin mRNA expression patterns in thyroid follicular cells obtained from the fine-needle aspiration biopsy specimens of patients diagnosed with simple nodular goitre, follicular adenoma, papillary and follicular well-differentiated carcinomas.
  • Prothymosin alpha and parathymosin mRNA levels were found significantly elevated in well-differentiated carcinomas in relation to adenomas (p<0.05) and goitres (p<0.05), an event possibly linked to the proliferation activity of thyroid follicular cells.
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Adult. Aged. Biomarkers / analysis. Biopsy, Fine-Needle / methods. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Proliferation. Diagnosis, Differential. Female. Humans. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction / methods. Thyroid Nodule / genetics. Thyroid Nodule / pathology

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  • (PMID = 17203893.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Protein Precursors; 0 / RNA, Messenger; 0 / prothymosin alpha; 61512-21-8 / Thymosin; 95328-48-6 / parathymosin alpha
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10. Fournie JW, Wolfe MJ, Wolf JC, Courtney LA, Johnson RD, Hawkins WE: Diagnostic criteria for proliferative thyroid lesions in bony fishes. Toxicol Pathol; 2005;33(5):540-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Specific diagnostic criteria are provided for all lesion categories including follicular cell hyperplasia (simple, nodular, or ectopic), adenoma (papillary or solid), and carcinoma (well- or poorly differentiated).

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  • (PMID = 16076769.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Puskas LG, Juhasz F, Zarva A, Hackler L Jr, Farid NR: Gene profiling identifies genes specific for well-differentiated epithelial thyroid tumors. Cell Mol Biol (Noisy-le-grand); 2005 Sep 5;51(2):177-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To that end we have studied gene profiles of 5 types of benign and malignant thyroid nodular tissue (multinodular goiter, follicular adenoma, papillary and follicular carcinomas).
  • We found, PCSK2, TRIB1, RAP1 GA1 to be specifically overexpressed in follicular cancer and S100A4 and GK2 in papillary carcinoma.
  • SERP1, RNASE 2 and STATA5 were suppressed in papillary thyroid cancer.
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / physiopathology. Adenoma / diagnosis. Adenoma / genetics. Adenoma / physiopathology. Biomarkers, Tumor / genetics. Biopsy, Fine-Needle. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / genetics. Carcinoma, Papillary / physiopathology. Gene Expression Regulation, Neoplastic. Goiter, Nodular / diagnosis. Goiter, Nodular / genetics. Goiter, Nodular / physiopathology. Humans. Microscopy, Confocal. Oligonucleotide Array Sequence Analysis. Polymerase Chain Reaction

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  • (PMID = 16171553.001).
  • [ISSN] 1165-158X
  • [Journal-full-title] Cellular and molecular biology (Noisy-le-Grand, France)
  • [ISO-abbreviation] Cell. Mol. Biol. (Noisy-le-grand)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. Luo H, Li J, Yang T, Wang J: [Expression and significance of VEGF-C and VEGF-D in differentiated thyroid carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Jun;23(12):531-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: A tissue microarray containing 71 specimens was constructed, including normal thyroid tissues, thyroid adenoma, papillary thyroid carcinoma with and without lymphatic metastasis, follicular thyroid carcinoma.
  • RESULT: The expression of VEGF-C,D were not observed in normal thyroid tissues and adenoma tissues.
  • The expression of VEGF-C,D in papillary thyroid carcinoma was significantly higher than those in follicular thyroid carcinoma (P < 0.05) and adeno ma tissues (P < 0.01).
  • The expression of VEGF-C,D in papillary thyroid carcinoma with lymphatic metastasis was significantly higher than those in papillary thyroid carcinoma without lymphatic metastasis (P < 0.05).
  • CONCLUSION: By inducing proliferation of lymphatic endothelia cell and development of lymphatic vessels, VEGF-C,D contributed to lymphatic metastasis of papillary thyroid carcinoma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Thyroid Neoplasms / pathology. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor D / biosynthesis

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  • (PMID = 19771906.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / VEGFC protein, human; 0 / Vascular Endothelial Growth Factor C; 0 / Vascular Endothelial Growth Factor D
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13. Gesierich W, Diwersy C, Leinsinger G, Massmann J, Präuer H, Höfler H, Fend F, Emslander HP: [Papillary adenoma of type-II pneumocytes as a rare differential diagnosis of a solitary pulmonary nodule]. Pneumologie; 2007 Nov;61(11):697-9
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  • [Title] [Papillary adenoma of type-II pneumocytes as a rare differential diagnosis of a solitary pulmonary nodule].
  • [Transliterated title] Papilläres Adenom der Typ-II-Pneumozyten als seltene Differenzialdiagnose eines pulmonalen Rundherdes.
  • The case of a 66-year-old, asymptomatic patient with a papillary adenoma of type-II pneumocytes is reported.
  • Papillary adenoma of type-II pneumocytes is a rare tumor, whose origin is suspected in progenitor cells of the bronchioloalveolar epithelium with the potential to differentiate towards type-II pneumocytes and clara cells.
  • The tumor is regarded as benign, however, a malignant potential is not excluded by some authors.
  • [MeSH-major] Adenoma / diagnosis. Lung / pathology. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / etiology

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  • (PMID = 17886196.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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14. Morine Y, Shimada M, Imura S, Uchiyama H, Uchiyama H, Kanemura H, Arakawa Y, Hanaoka J, Sugimoto K: Clinical role of regulatory T cell in intraductal papillary mucinous neoplasms. J Clin Oncol; 2009 May 20;27(15_suppl):e15537

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical role of regulatory T cell in intraductal papillary mucinous neoplasms.
  • : e15537 Background: Intraductal papillary mucinous neoplasms of pancreas (IPMNs) have malignant potential and exhibit a broad histologic spectrum, ranging from adenoma to invasive carcinoma.

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  • (PMID = 27962313.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Papla B: Papillary adenoma of the lung. Pol J Pathol; 2009;60(1):49-51
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  • [Title] Papillary adenoma of the lung.
  • The report presents a very rare case of papillary adenoma of the lung in a 61-year old man, described for the first time in the Polish literature.
  • [MeSH-major] Adenoma / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 19670704.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Pulmonary Surfactant-Associated Protein A; 68238-35-7 / Keratins
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16. Kuwahara M, Nagafuchi M, Rikimaru T, Iwasaki A, Shirakusa T: Pulmonary papillary adenoma. Gen Thorac Cardiovasc Surg; 2010 Oct;58(10):542-5
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  • [Title] Pulmonary papillary adenoma.
  • We present a rare case of solitary pulmonary papillary adenoma.
  • The previous physician had considered it to be an old benign inflammatory granuloma and had kept it under observation.
  • On postoperative pathology examination, the nodule was found to be a circumscribed nodule consisting of a papillary growth of cuboidal to low-columnar epithelial cells lining the surface of a fibrovascular stroma.
  • The histological features were consistent with pulmonary papillary adenoma.
  • Only 20 cases of pulmonary papillary adenoma have been reported in the literature.
  • [MeSH-major] Adenoma / pathology. Lung Neoplasms / pathology. Solitary Pulmonary Nodule / pathology

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  • (PMID = 20941571.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Sotona O, Cecka F, Neoral C, Ferko A, Rejchrt S, Podhola M, Subrt Z, Jon B: Papillary adenoma of the extrahepatic biliary tract--a rare cause of obstructive jaundice. Acta Gastroenterol Belg; 2010 Apr-Jun;73(2):270-3
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  • [Title] Papillary adenoma of the extrahepatic biliary tract--a rare cause of obstructive jaundice.
  • The authors present a case of papillary adenoma of the extrahepatic biliary tract presenting as obstructive jaundice.
  • Adenoma of the bile duct is a rare entity.
  • [MeSH-major] Adenoma / complications. Bile Duct Neoplasms / complications. Bile Ducts, Extrahepatic. Jaundice, Obstructive / etiology

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  • (PMID = 20690568.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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18. Keramidas EG, Miller G, Revelos K, Kitsanta P, Page RE: Aggressive digital papillary adenoma-adenocarcinoma. Scand J Plast Reconstr Surg Hand Surg; 2006;40(3):189-92

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  • [Title] Aggressive digital papillary adenoma-adenocarcinoma.
  • Aggressive digital papillary adenocarcinoma and aggressive digital papillary adenoma are rare tumours of the sweat glands.

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  • (PMID = 16687341.001).
  • [ISSN] 0284-4311
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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19. Wang KL, Weinrach DM, Luan C, Han M, Lin F, Teh BT, Yang XJ: Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma. Hum Pathol; 2007 Feb;38(2):239-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma.
  • The purpose of this study is to determine the incidence, histomorphological features, and immunohistochemical features of papillary adenoma and elucidate its potential relationship to RCC.
  • Thirty-eight (7%) nephrectomy specimens showed histologic evidence of papillary adenoma.
  • Of these 38 cases, 18 (47%) arose in the setting of papillary RCC (PRCC).
  • Seven papillary adenomas (18%) occurred in the setting of acquired polycystic kidney disease (APKD), 6 in clear-cell RCCs, 3 in chromophobe RCCs, 2 in end-stage kidney disease, 1 in oncocytoma, 1 in angiomyolipoma, and 1 in renal schwannoma.
  • Furthermore, papillary adenomas were more commonly found in kidneys removed for PRCC (25%, 18/71) than in kidneys harboring clear-cell RCC (1.9%, 6/318).
  • Histomorphologically, papillary adenomas were characterized by varying proportions of papillae and tubules formed by cuboidal cells with scant basophilic cytoplasm similar to those in type 1 PRCC.
  • Adenomas associated with PRCC tend to be multiple in number (61% [11/18] of cases had >2 adenomas; mean, 5).
  • In contrast, 100% of papillary adenomas arising in other conditions had less than 2 adenomas.
  • Most of the adenomas (82%, 31/38) stained strongly for AMACR in a fashion similar to that of PRCC.
  • In this study of surgical specimens, the high coincidence, multifocality, and histologic and immunohistochemical similarities between papillary adenoma and PRCC suggest that the 2 are strongly associated and may represent a continuum of 1 biologic process.
  • In contrast, adenomas associated with APKD exhibit distinct morphological and immunohistochemical features and, therefore, may have an entirely different pathogenesis.
  • [MeSH-major] Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / enzymology. Adenocarcinoma, Clear Cell / pathology. Adenoma. Adenoma, Oxyphilic / enzymology. Adenoma, Oxyphilic / pathology. Adult. Aged. Aged, 80 and over. Angiomyolipoma / enzymology. Angiomyolipoma / pathology. Disease Progression. Female. Glutathione Transferase / analysis. Humans. Immunohistochemistry. Isoenzymes / analysis. Kidney / enzymology. Kidney / pathology. Kidney Failure, Chronic / enzymology. Kidney Failure, Chronic / pathology. Male. Middle Aged. Models, Biological. Polycystic Kidney Diseases / enzymology. Polycystic Kidney Diseases / pathology. Racemases and Epimerases / analysis

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  • (PMID = 17056094.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase alpha; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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20. Morris-Stiff GJ, Senda Y, Verbeke CS, Lodge PA: Papillary adenoma arising in the left hepatic duct: an unusual tumour in an uncommon location. Eur J Gastroenterol Hepatol; 2010 Jul;22(7):886-8
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  • [Title] Papillary adenoma arising in the left hepatic duct: an unusual tumour in an uncommon location.
  • Bile duct adenomas are rare tumours that arise more frequently in the distal extrahepatic biliary tree.
  • We report the case of a papillary adenoma arising at the junction of the common and left hepatic ducts and review the available literature on this rare entity.
  • At laparotomy, there was no evidence of extraductal tumour, and choledochoscopy showed a papillary lesion within the common hepatic and proximal left hepatic ducts.
  • Histological evaluation of the resected specimen confirmed a papillary adenoma with mild dysplasia.
  • [MeSH-major] Adenoma / diagnosis. Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic

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  • (PMID = 20545030.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.3.2.2 / gamma-Glutamyltransferase
  • [Number-of-references] 10
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21. Puppa G, Gervasio A, Yorukoglu K, Colombari R, De Marchi F, Canzonieri V: Huge renal cyst with parietal renal cell carcinoma, osseous metaplasia and a papillary adenoma: a case report with unique clinicopathological features and literature review. Virchows Arch; 2008 Mar;452(3):325-30
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  • [Title] Huge renal cyst with parietal renal cell carcinoma, osseous metaplasia and a papillary adenoma: a case report with unique clinicopathological features and literature review.
  • The unique clinicopathological features of a giant solitary renal cyst with a parietal clear cell carcinoma in contiguity with a focus of osseous metaplasia and a papillary adenoma are reported.
  • After extensive pathological sampling of the cyst's wall, a focus of osseous metaplasia in contiguity with the main tumour and a microscopic papillary adenoma were found.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Diseases, Cystic / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18080136.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Keratin-7; EC 3.4.24.11 / Neprilysin
  • [Number-of-references] 19
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22. Nelson KK, Gattuso P, Xu X, Prinz RA: Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. Surgery; 2010 Oct;148(4):654-60; discussion 660
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  • [Title] Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy.
  • This study determines whether 3 molecules, Patched, Smoothened, and Sonic Hedgehog, involved in the Sonic Hedgehog pathway are overexpressed equally in synchronous follicular thyroid adenoma and papillary thyroid carcinoma.
  • METHODS: Eighteen patients with synchronous follicular thyroid adenoma and papillary thyroid carcinoma underwent thyroidectomy.
  • Patched expression was detected in 5 of 13 (38%) follicular adenomas and 5 of 12 (42%) papillary carcinomas.
  • Smoothened was expressed in 4 of 13 (31%) follicular adenomas and 3 of 13 (23%) papillary carcinomas.
  • Sonic Hedgehog was expressed in 4 of 13 (31%) follicular adenomas and 11 of 13 (85%) papillary carcinomas.
  • CONCLUSION: Expression of the 3 molecules involved in the Sonic Hedgehog pathway was similar in follicular thyroid adenoma, but Sonic Hedgehog expression was a more sensitive indicator of malignancy in papillary thyroid carcinoma.
  • The Sonic Hedgehog molecule may become a diagnostic marker when the cytologic or histologic features are not characteristic of a papillary carcinoma.
  • Greater understanding of the Sonic Hedgehog pathway may provide molecular methods for preventing or treating papillary thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / metabolism. Adenoma / metabolism. Hedgehog Proteins / biosynthesis. Thyroid Neoplasms / metabolism

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20797751.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / SHH protein, human
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23. Mai KT, Elmontaser G, Perkins DG, Thomas J, Stinson WA: Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. Int J Surg Pathol; 2005 Jan;13(1):37-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma.
  • We studied the significance of encapsulated Hürthle cell thyroid nodules with papillary structures lacking the nuclear features of papillary thyroid carcinoma (PTC); 19 cases fulfilling these criteria were encountered The patients' ages ranged from 22 to 40 years (32+/-6), and the F:M ratio was 3:1 The tumors measured from 0.5-5 cm (2+/-1.1).
  • Immunohistochemically, there was reactivity for MIB-1 in the papillary structures, negativity to focally weak reactivity for HBME and galectin-3, and negativity to moderate diffuse reactivity for CK19.
  • It is unlikely that the papillary structures in the study cases represent degenerative changes in view of the proliferative activity we have demonstrated in them.
  • In view of (1) the encapsulation and the uniformity of the constituent cells, (2) the negative or weak immunoreactivity for galectin-3 and HBME and negative to moderate immunoreactivity for CK19, and (3) the absence or paucity of nuclear criteria for the diagnosis of PTC and the absence of lymph node metastasis in all study cases, we believe that these lesions represent the papillary variant of oncocytic follicular adenoma (Hürthle cell adenoma).
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Carcinoma, Papillary, Follicular / diagnosis. Thyroid Neoplasms / pathology

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  • (PMID = 15735853.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromatin
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24. Bhattacharya TK, Rani S, Maiti SK, Dayal S, Kumar P, Sharma A: Polymorphism of ZuBeCa3 microsatellite and its association with mammary tumor in dogs. Int J Immunogenet; 2007 Jun;34(3):161-5
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  • Histopathological observation classified the cancer-affected animals into three groups namely, malignant solid mammary carcinoma, malignant papillary adenocarcinoma and benign papillary adenoma in which the frequency of A allele was relatively more predominant in benign tumor group, which is more than 80%.
  • [MeSH-major] Adenocarcinoma, Papillary / genetics. Adenoma / genetics. Breast Neoplasms / genetics. Carcinoma / genetics. Microsatellite Repeats / genetics

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  • (PMID = 17504505.001).
  • [ISSN] 1744-3121
  • [Journal-full-title] International journal of immunogenetics
  • [ISO-abbreviation] Int. J. Immunogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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25. Zhou M, Yang XJ, Lopez JI, Shah RB, Hes O, Shen SS, Li R, Yang Y, Lin F, Elson P, Sercia L, Magi-Galluzzi C, Tubbs R: Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. Am J Surg Pathol; 2009 Dec;33(12):1840-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification.
  • In this study, we provide pathologic and cytogenetic evidence supporting that TC-RCC is closely related to papillary RCC (PRCC).
  • Pathologic examination documented the gross and microscopic features of TC-RCC, including multicentricity and the presence of concomitant PRCC and papillary adenoma.
  • Ten had associated PRCC or papillary adenoma within the same kidney as the TC-RCC.
  • In 4 cases, the tubulocystic and papillary components were admixed together within the same lesion.
  • The tumor cells lining both the tubulocystic and papillary components had similar cytologic features.
  • With its distinctive gross and microscopic features, TC-RCC may be considered a unique "morphologic entity."
  • [MeSH-major] Adenoma / pathology. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Kidney Tubules / pathology


26. Munshi AG, Hassan MA: Common bile duct adenoma: case report and brief review of literature. Surg Laparosc Endosc Percutan Tech; 2010 Dec;20(6):e193-4
The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for bile duct adenoma .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Common bile duct adenoma: case report and brief review of literature.
  • Papillary adenomas of the common bile duct are a rare entity with few published case reports and limited knowledge on its natural progression.
  • We report here a case of common bile duct papillary adenoma in a 69-year-old female who presented with symptoms of common bile duct obstruction.
  • She was treated with local endoscopic excision of the mass that has benign features.
  • A brief review of literature is discussed with a proposed treatment plan for follow-up with surveillance endoscopy and ultrasonography as opposed to the radical resection for benign findings on pathology.
  • [MeSH-major] Adenoma / surgery. Common Bile Duct Neoplasms / surgery

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  • (PMID = 21150400.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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27. Kunisaki SM, Hertl M, Bodner BE, Cosimi AB: Mirizzi syndrome secondary to an adenoma of the cystic duct. J Hepatobiliary Pancreat Surg; 2005;12(2):159-62
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  • [Title] Mirizzi syndrome secondary to an adenoma of the cystic duct.
  • Bile duct adenomas are uncommon lesions that can cause obstructive jaundice.
  • We report the unusual case of a 54-year-old man who developed Mirizzi syndrome secondary to a bile duct papillary adenoma located in the cystic duct remnant.
  • A case report is presented, together with a review of extrahepatic bile duct adenomas published in the English-language literature, with special attention directed toward the clinical manifestations, locations, and prognosis of these tumors.
  • Bile duct adenomas are very rare tumors.
  • We describe here a very rare, acalculous variant of Mirizzi syndrome secondary to a solitary papillary adenoma of the cystic duct.
  • In general, bile duct adenomas are uncommon lesions that are difficult to diagnoses preoperatively.
  • [MeSH-major] Adenoma / complications. Bile Duct Neoplasms / complications. Cholestasis / etiology. Cystic Duct

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  • (PMID = 15868083.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 28
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28. Caliumi C, Cotesta D, Petramala L, Lorio M, Salvati M, Filetti S, De Toma G, D'Erasmo E, Letizia C: An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. Tumori; 2006 Mar-Apr;92(2):178-80
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  • [Title] An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma.
  • The case of a 50-year-old woman with cerebral meningioma and concomitant parathyroid adenoma and papillary thyroid carcinoma is presented.
  • Histological examination revealed a parathyroid adenoma and a small papillary carcinoma of 0.4 cm in the right thyroid lobe.
  • As far as we know, this patient is the third case of meningioma associated with parathyroid adenoma and papillary thyroid carcinoma described in the literature.
  • [MeSH-major] Adenoma / diagnosis. Brain Neoplasms / diagnosis. Carcinoma, Papillary / diagnosis. Meningioma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parathyroid Neoplasms / diagnosis. Thyroid Neoplasms / diagnosis


29. Nguyen HD, Galitz MS, Mai VQ, Clyde PW, Glister BC, Shakir MK: Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. Thyroid; 2010 Jan;20(1):99-103
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  • [Title] Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge.
  • BACKGROUND: A thyrotropin (TSH)-secreting pituitary adenoma coexisting with differentiated thyroid carcinoma is rare.
  • METHODS: We hereby report the fifth case, in which a patient presented with a TSH/growth-hormone-secreting pituitary macroadenoma coexisting with papillary thyroid carcinoma (PTC).
  • She has remained asymptomatic for 24 months without biochemical or radiological evidence of pituitary hormone oversecretion, pituitary adenoma enlargement, and PTC recurrence.
  • [MeSH-major] Adenoma. Carcinoma, Papillary. Human Growth Hormone / biosynthesis. Neoplasms, Multiple Primary. Pituitary Neoplasms. Thyroid Neoplasms. Thyrotropin / biosynthesis

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  • (PMID = 20067380.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Delayed-Action Preparations; 0 / Iodine Radioisotopes; 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine; RWM8CCW8GP / Octreotide
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30. Hayashibe A, Sakamoto K, Shinbo M, Makimoto S, Nakamoto T: A resected case of multiple intraductal papillary mucinous tumors of the pancreas with US-guided ductal branch-oriented partial pancreatectomy. Pancreatology; 2005;5(4-5):462-5
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  • [Title] A resected case of multiple intraductal papillary mucinous tumors of the pancreas with US-guided ductal branch-oriented partial pancreatectomy.
  • A 69-year-old man with epigastralgia was admitted on August 26, 2002 and diagnosed with multiple intraductal papillary mucinous tumors by various imagings.
  • It was believed that the tumors were benign.
  • The operation was successful, and the histopathological diagnosis of the tumors was intraductal papillary adenoma of the pancreas.
  • [MeSH-major] Adenoma / surgery. Digestive System Surgical Procedures. Pancreatectomy / methods. Pancreatic Ducts / surgery. Pancreatic Neoplasms / surgery

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  • [Copyright] Copyright 2005 S. Karger AG, Basel and IAP.
  • (PMID = 15985773.001).
  • [ISSN] 1424-3903
  • [Journal-full-title] Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • [ISO-abbreviation] Pancreatology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Mucins
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31. Miguel-Pérez P, Herrera-Hernández M, Padilla-Rodríguez A, Martínez-Consuegra N: [Thyroid oncocytic adenoma. A review of the morphological spectrum in four cases]. Gac Med Mex; 2007 Nov-Dec;143(6):517-22
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  • [Title] [Thyroid oncocytic adenoma. A review of the morphological spectrum in four cases].
  • [Transliterated title] Adenoma oncocítico de tiroides (adenoma de células de Hürthle). Revisión del espectro morfológico a propósito de cuatro casos.
  • In the thyroid gland, this change is a metaplastic phenomenon that takes place under different circumstances that promote cellular stress, and could even produce a true neoplasm, both benign or malignant.
  • The oncocytic adenoma, a malignant tumor will be described.
  • Tumor characteristics in all cases included: massive ischemic necrosis short after a fine needle aspiration biopsy was performed, unexpected large size, coexistence with a malignant independent neoplasm and cytological features similar to those observed in papillary carcinomas.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18269084.001).
  • [ISSN] 0016-3813
  • [Journal-full-title] Gaceta médica de México
  • [ISO-abbreviation] Gac Med Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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32. Gokden N, Li L, Zhang H, Schafer RF, Schichman S, Scott MA, Smoller BR, Fan CY: Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenoma. Pathol Int; 2008 Jun;58(6):339-43
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  • [Title] Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenoma.
  • Even though some studies found similar genetic alterations between renal papillary adenomas (PA) and papillary RCC (PRCC), no studies have been conducted to compare the alterations of hOGG1 gene in PA, PRCC and CC-RCC.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Renal Cell / genetics. DNA Glycosylases / genetics. DNA Repair / genetics. Kidney Neoplasms / genetics


33. Sharma SG, Gokden M, McKenney JK, Phan DC, Cox RM, Kelly T, Gokden N: The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary features. Appl Immunohistochem Mol Morphol; 2010 Dec;18(6):494-8
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  • [Title] The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary features.
  • PAX-2, a homeogene expressed during kidney development, has been studied as a marker of renal origin in both primary and metastatic clear cell renal cell carcinoma (RCC), but not in papillary neoplasms or in comparison with RCC marker (RCCma).
  • We studied immunohistochemical expression of PAX-2 and RCCma in 24 papillary RCC (PRCC) and 66 nonrenal cell papillary neoplasms (NRCPN) from a variety of organs.
  • Of the NRCPN, 9/66 (14%) is positive for PAX-2 [4/10 (40%) ovarian papillary serous carcinomas, 5/9 (56%) uterine papillary serous carcinomas]; RCCma was positive in 28/66 (42%), including 9/9 (100%) papillary thyroid carcinomas, 8/10 (80%) ovarian papillary serous carcinomas, 4/9 (44%) uterine papillary serous carcinomas, 1/10 (10%) papillary urothelial carcinomas, 1/2 (50%) intraductal papillary mucinous carcinomas of the pancreas, 3/3 (100%) choroid plexus papillomas, 1/1 (100%) pituitary adenoma with papillary features, and 1/2 (50%) lung adenocarcinomas with papillary features.
  • PAX-2 and RCCma immunohistochemistry should be interpreted with caution in papillary neoplasms, with particular attention to the possibility of ovarian and uterine papillary serous carcinomas, which can express both PAX-2 and RCCma.
  • [MeSH-major] Advanced Glycosylation End Product-Specific Receptor / analysis. Biomarkers, Tumor / analysis. Carcinoma, Papillary / chemistry. Carcinoma, Papillary / diagnosis. Carcinoma, Renal Cell / chemistry. Carcinoma, Renal Cell / diagnosis. Immunohistochemistry. Kidney Neoplasms / chemistry. Kidney Neoplasms / diagnosis. PAX2 Transcription Factor

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  • (PMID = 21102195.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / Biomarkers, Tumor; 0 / PAX2 Transcription Factor
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34. Baek SK, Woo JS, Kwon SY, Lee SH, Chae YS, Jung KY: Prognostic significance of the MUC1 and MUC4 expressions in thyroid papillary carcinoma. Laryngoscope; 2007 May;117(5):911-6
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  • [Title] Prognostic significance of the MUC1 and MUC4 expressions in thyroid papillary carcinoma.
  • OBJECTIVES: The aim of the present study was to examine the expressions of mucin genes MUC1 and MUC4 and to evaluate the difference of their expressions in normal thyroid tissue, follicular adenoma, and papillary carcinoma.
  • Furthermore, we aimed to estimate their prognostic significance in papillary carcinoma.
  • METHODS: We performed semiquantitative reverse-transcription polymerase chain reaction for determining the MUC1 and MUC4 mRNA expressions, and immunohistochemical staining was performed to determine the MUC1 and MUC4 protein expressions in 22 normal thyroid tissues, 22 follicular adenomas, and 15 papillary carcinomas.
  • The semiquantitative scoring of the immunohistochemical staining was compared with the prognostic factors for thyroid carcinoma to evaluate the prognostic significance in 87 papillary carcinoma patients.
  • RESULTS: The MUC1 mRNA of the papillary carcinoma tissue showed an increased expression level compared with the other tissues.
  • MUC1 immunoreactivity was more intense in papillary carcinoma but not in the other tissues.
  • CONCLUSIONS: Up-regulation of MUC1 may play a more important role than that of MUC4 in the development of thyroid papillary carcinoma, and it may have some significance as a prognostic factor.
  • [MeSH-major] Carcinoma, Papillary / metabolism. Mucin-1 / metabolism. Mucins / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 17473695.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC4 protein, human; 0 / Mucin-1; 0 / Mucin-4; 0 / Mucins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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35. Blasini W, Hu S, Gugic D, Vincek V: Papillary eccrine adenoma in association with cutaneous horn. Am J Clin Dermatol; 2007;8(3):179-82
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  • [Title] Papillary eccrine adenoma in association with cutaneous horn.
  • Papillary eccrine adenoma (PEA) is an uncommon sweat gland neoplasm that occurs more frequently on the distal extremities of Black women.
  • [MeSH-major] Adenoma / complications. Keratosis / complications. Sweat Gland Neoplasms / complications

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  • (PMID = 17492846.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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36. Nakamura N, Erickson LA, Jin L, Kajita S, Zhang H, Qian X, Rumilla K, Lloyd RV: Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma. Endocr Pathol; 2006;17(3):213-23
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  • [Title] Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma.
  • These analyses showed that several antibodies were useful in distinguishing follicular adenomas from follicular variant of papillary thyroid carcinomas including HBME-1, CITED1, galectin-3, cytokeratin 19, and S100A4 (p < 0.0001).
  • A combination of markers consisting of a panel of HBME-1, galectin-3, and CK19 or a panel of HBME-1, CITED1, and galectin-3 was usually most effective in distinguishing follicular adenoma from follicular variant of papillary thyroid carcinoma.
  • These results indicate that some individual antibodies or a panel of antibodies combined with histopathological analysis can be useful in separating follicular adenoma (FA) from follicular variant of papillary thyroid carcinoma (FVPTC).
  • [MeSH-major] Adenoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Papillary, Follicular / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 17308358.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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37. Ishida M, Egawa S, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Furukawa T, Unno M: Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma. J Hepatobiliary Pancreat Surg; 2007;14(5):522-5
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  • [Title] Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma.
  • A 72-year-old woman, who had undergone pylorus-preserving pancreatoduodenectomy 3 years before for cancer of Vater's papilla associated with a branch-type intraductal papillary-mucinous adenoma (IPMA), developed dilatation of the main duct and a nodular lesion in the remnant pancreas.
  • Total pancreatectomy was performed, which revealed that the lesion was intraductal papillary-mucinous adenocarcinoma (IPMC) with minimal invasion, suggesting the metachronous multicentric occurrence of this intraductal papillary-mucinous neoplasm (IPMN).

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  • (PMID = 17909725.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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38. Evenson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren PO: Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg; 2007 Jun;193(6):707-12
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  • [Title] Hyalinizing trabecular adenoma--an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma.
  • BACKGROUND: Hyalinizing trabecular adenoma (HTA) is an uncommon benign thyroid tumor that can present as a solitary thyroid nodule, a prominent nodule in a multinodular goiter, or as an incidental finding in a thyroidectomy specimen.
  • The clinical significance of the lesion is that it is frequently misdiagnosed as papillary carcinoma on fine-needle aspiration cytology or as papillary or medullary carcinoma on histopathological section.
  • RESULTS: In 4 patients, the preoperative cytology was suggestive of papillary carcinoma, in 2 patients suspicious, and in 1 patient positive for papillary carcinoma.
  • Except in 1 patient, who had a microscopic focus (3.2 mm) of papillary carcinoma, there was no evidence of malignancy in the surgical specimens on permanent histopathological section.
  • [MeSH-major] Adenoma / pathology. Diagnostic Errors. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Carcinoma, Medullary / diagnosis. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Thyroidectomy

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  • (PMID = 17512281.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Kazakov DV, Mukensnabl P, Michal M: Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol; 2006 Apr;28(2):142-6
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  • [Title] Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
  • The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues.
  • We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation.
  • The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia.
  • In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation.
  • [MeSH-major] Adenoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Back. Cell Differentiation. Cell Lineage. Eosinophils / pathology. Epithelial Cells / pathology. Epithelium / pathology. Female. Fibroblasts / pathology. Follow-Up Studies. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Humans. Middle Aged. Scalp / pathology. Sebaceous Glands / pathology

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  • (PMID = 16625077.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Kummerfeld M, Knieriem A, Wohlsein P: [Osteomyelitis and papillary renal adenoma in a red panda (Ailurus fulgens fulgens)]. Dtsch Tierarztl Wochenschr; 2008 Nov;115(11):421-5
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  • [Title] [Osteomyelitis and papillary renal adenoma in a red panda (Ailurus fulgens fulgens)].
  • [Transliterated title] Osteomyelitis und papilläres renales Adenom bei einem Kleinen Pandabären (Ailurus fulgens fulgens).
  • Additionally, in the kidney a papillary renal adenoma was found.

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  • (PMID = 19024549.001).
  • [ISSN] 0341-6593
  • [Journal-full-title] DTW. Deutsche tierärztliche Wochenschrift
  • [ISO-abbreviation] DTW. Dtsch. Tierarztl. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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41. Ganguly R, Mitra S, Datta AK: Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. Indian J Pathol Microbiol; 2010 Apr-Jun;53(2):337-9

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  • [Title] Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland.
  • Accordingly, anaplastic carcinomas have been seen to coincide with simultaneous papillary and follicular cancers.
  • We report a case of composite anaplastic and papillary cancer on one thyroid lobe with a follicular carcinoma in the other lobe in a female patient aged 64 years.
  • The patient also had a separate and independent follicular adenoma in the same lobe as the composite anaplastic and papillary carcinoma.
  • The papillary carcinoma was continuous with the anaplastic carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / complications. Adenoma / complications. Carcinoma / complications. Carcinoma, Papillary / complications. Thyroid Gland / pathology

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  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):434-5 [21623130.001]
  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):414-5; author reply 415 [21623114.001]
  • (PMID = 20551551.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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42. Sak SD, Koseoglu RD, Demirag F, Akbulut H, Gungor A: Alveolar adenoma of the lung. Immunohistochemical and flow cytometric characteristics of two new cases and a review of the literature. APMIS; 2007 Dec;115(12):1443-9
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  • [Title] Alveolar adenoma of the lung. Immunohistochemical and flow cytometric characteristics of two new cases and a review of the literature.
  • Alveolar adenoma is a rare and benign tumour of the lung that usually presents in asymptomatic patients as a coin lesion on chest radiography.
  • Alveolar adenoma has a characteristic multicystic histology and often resembles the normal lung parenchyma.
  • Immunohistochemical analysis may aid in the characterization of alveolar adenoma and discriminate this condition from other types of benign lesions of the lung.
  • An indolent clinical progression and absence of recurrence and metastasis after complete resection are the most important characteristics indicative of the benign nature of alveolar adenoma.
  • Few studies have been conducted at the molecular level, such as by flow cytometry, with the objective of characterizing the biological nature of alveolar adenoma.
  • Differential diagnoses include sclerosing hemangioma, papillary adenoma, lymphangioma, atypical adenomatous hyperplasia and bronchioloalveolar carcinoma.
  • [MeSH-major] Adenoma / pathology. Pulmonary Alveoli / pathology. Solitary Pulmonary Nodule / pathology

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  • (PMID = 18184418.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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43. Stolf BS, Abreu CM, Mahler-Araújo MB, Dellamano M, Martins WK, de Carvalho MB, Curado MP, Díaz JP, Fabri A, Brentani H, Carvalho AF, Soares FA, Kowalski LP, Hirata R Jr, Reis LF: Expression profile of malignant and non-malignant diseases of the thyroid gland reveals altered expression of a common set of genes in goiter and papillary carcinomas. Cancer Lett; 2005 Sep 8;227(1):59-73
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  • [Title] Expression profile of malignant and non-malignant diseases of the thyroid gland reveals altered expression of a common set of genes in goiter and papillary carcinomas.
  • Using cDNA microarrays with 3800 cDNA fragments, we determined the expression profile of normal thyroid tissue, goiter, adenoma and papillary carcinoma (10 samples from each class).
  • Here we demonstrate that, at least on the basis of these differentially expressed genes, a positive correlation between goiter and papillary carcinomas could be observed.
  • We identified a common set of genes whose expression is diminished in both goiter and papillary carcinomas as compared to normal thyroid tissue.
  • Moreover, no genes with inverse correlation in samples from goiter and papillary carcinomas could be detected.
  • Of notice, we demonstrate that the reduced mRNA levels of p27(kip1) observed in papillary carcinomas as compared to either goiter or normal thyroid tissues (P<0.001) is accompanied by an altered protein distribution within the cell.
  • In papillary carcinomas, P27(KIP1) is preferentially cytoplasmic as opposed to goiter or normal thyroid tissue, where P27(KIP1) is preferentially located in the nucleus.
  • The exploitation of the data presented here could contribute to the understanding of the molecular events related to thyroid diseases and gives support to the notion that common molecular events might be related to the frequent observation of areas of papillary carcinomas in the gland of patients with goiter.
  • [MeSH-major] Carcinoma, Papillary / genetics. Gene Expression Profiling. Goiter / genetics. Thyroid Gland / metabolism. Thyroid Neoplasms / genetics

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  • (PMID = 16051032.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / CDKN1B protein, human; 0 / Carrier Proteins; 0 / Intracellular Signaling Peptides and Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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44. Matsuda K, Kousaka Y, Nagamine N, Tsunoda N, Taniyama H: Papillary renal adenoma of distal nephron differentiation in a horse. J Vet Med Sci; 2007 Jul;69(7):763-5
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  • [Title] Papillary renal adenoma of distal nephron differentiation in a horse.
  • The mass was encapsulated with fibrous capsule and composed of variably-sized papillary projections lined by a single layer of flattened to cuboidal neoplastic epithelial cells with no cytological and nuclear atypia.
  • From these results, this case was diagnosed as papillary renal adenoma of distal nephron differentiation.

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  • (PMID = 17675811.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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45. Kim WJ, Souillard R, Brandwein MS, Lawson W, Som PM: Follicular adenoma in a juxtathyroidal thyroglossal duct cyst with papillary carcinoma in the adjacent thyroid gland. Am J Otolaryngol; 2005 Sep-Oct;26(5):348-50
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  • [Title] Follicular adenoma in a juxtathyroidal thyroglossal duct cyst with papillary carcinoma in the adjacent thyroid gland.
  • This patient presented with a neck mass diagnosed as a papillary thyroid carcinoma by fine-needle aspiration.
  • Preoperative computed tomography revealed a papillary carcinoma within a juxtathyroidal thyroglossal duct cyst.
  • After surgery, the initial diagnosis was papillary thyroid carcinoma.
  • After correlation with the computed tomography, the diagnosis was revised to a papillary thyroid carcinoma plus a follicular adenoma in a juxtathyroidal thyroglossal duct cyst.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma, Papillary / diagnosis. Thyroglossal Cyst / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 16137536.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Kim SY, Lee JM, Kim SH, Shin KS, Kim YJ, An SK, Han CJ, Han JK, Choi BI: Macrocystic neoplasms of the pancreas: CT differentiation of serous oligocystic adenoma from mucinous cystadenoma and intraductal papillary mucinous tumor. AJR Am J Roentgenol; 2006 Nov;187(5):1192-8
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  • [Title] Macrocystic neoplasms of the pancreas: CT differentiation of serous oligocystic adenoma from mucinous cystadenoma and intraductal papillary mucinous tumor.
  • OBJECTIVE: The purpose of our study was to determine useful CT criteria for differentiating serous oligocystic adenomas of the pancreas from other similarly presenting neoplasms, such as mucinous cystadenoma and intraductal papillary mucinous tumor of the branch duct type.
  • MATERIALS AND METHODS: Forty-one patients with histologically confirmed macrocystic neoplasms of the pancreas were enrolled: serous oligocystic adenoma in 10 patients, mucinous cystadenoma in 13, and intraductal papillary mucinous tumor in 18.
  • RESULTS: Significant differences in lesion shape were found between serous oligocystic adenoma and the other macrocystic neoplasms (mucinous cystadenoma [p < 0.05], intraductal papillary mucinous tumor [p < 0.05]).
  • Serous oligocystic adenoma had a multicystic or lobulated contour with or without septation, whereas mucinous cystadenoma had a smooth contour with or without septation and intraductal papillary mucinous tumor had either a pleomorphic or a clubbed fingerlike cystic shape.
  • Serous oligocystic adenoma showed proximal MPD dilatation from the lesion, whereas intraductal papillary mucinous tumor showed distal or whole MPD dilatation (p < 0.05).
  • CONCLUSION: Serous oligocystic adenoma of the pancreas has characteristic CT findings that differentiate it from other cystic tumors.

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  • (PMID = 17056905.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Kohashi K, Oda Y, Nakamori M, Yamamoto H, Tamiya S, Toubo T, Kinoshita Y, Tajiri T, Taguchi T, Tsuneyoshi M: Multifocal metanephric adenoma in childhood. Pathol Int; 2009 Jan;59(1):49-52
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  • [Title] Multifocal metanephric adenoma in childhood.
  • Metanephric adenoma is the most commonly occurring member of the metanephric tumor family, which also includes metanephric adenofibroma and metanephric stromal tumor.
  • Reported herein is the case of a 9-year-old boy with multifocal metanephric adenoma.
  • Histologically, surgical sections showed multifocal proliferation of small rounded and uniform cells with smooth nuclear contours, scant pale-staining cytoplasm, dark-staining nuclei, and inconspicuous nucleoli: the cells were arranged in sheets and acinal, ductal, glomeruloid, and papillary structures.
  • Other histologically similar tumors are papillary renal cell carcinoma and nephroblastoma, and it is necessary to distinguish metanephric adenoma from those tumors because of malignancy.
  • In contrast to those tumors, metanephric adenoma has inconspicuous nucleoli, loss of CK7 and EMA expression, and no mitotic figures.
  • Thus, the histological and immunohistochemical features of the present case were compatible with metanephric adenoma.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19121092.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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48. Nagaike K, Chijiiwa K, Hiyoshi M, Ohuchida J, Kataoka H: Main-duct intraductal papillary mucinous adenoma of the pancreas with a large mural nodule. Int J Clin Oncol; 2007 Oct;12(5):388-91
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  • [Title] Main-duct intraductal papillary mucinous adenoma of the pancreas with a large mural nodule.
  • Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized entity representing a spectrum of benign and malignant neoplasms of the pancreas.
  • Preoperative distinction between benign and malignant IPMNs remains difficult.
  • The resected intraductal tumor appeared polypoid with a broad stalk and comprised a proliferation of mucin-containing columnar epithelial cells with papillary structures without malignant features.
  • The final diagnosis was intraductal papillary mucinous adenoma of the pancreas.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Cystadenoma, Mucinous / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17929124.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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49. Bukhari U, Sadiq S, Kehar SI: Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. J Pak Med Assoc; 2009 Jan;59(1):15-8
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  • [Title] Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma.
  • Formalin fixed paraffin embedded tissues of follicular adenoma, WDT-UMP and follicular variant of papillary carcinoma were obtained for CK 19 immunostaining.
  • RESULTS: All (16) cases of follicular adenoma were negative for CK19.
  • There were 43 cases of follicular variant of papillary carcinoma with 4+ CK 19 positivity, 14 were 3+ positive and 3 were 2+ positive.
  • CONCLUSION: CK19 is a good and useful diagnostic marker for differential diagnosis of follicular adenoma, WDT-UMP and follicular variant of papillary carcinoma.
  • [MeSH-major] Adenoma / physiopathology. Carcinoma, Papillary / physiopathology. Keratin-19

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  • (PMID = 19213370.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Keratin-19
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50. Kim JH, Choi JW, Seo YS, Lee BJ, Yeon JE, Kim JS, Byun KS, Bak YT, Kim I, Park JJ: Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum. World J Gastroenterol; 2007 Jun 21;13(23):3262-4
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  • [Title] Inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum.
  • Benign neoplasia of the duodenum are very rare.
  • Moreover, duodenal tubulovillous adenomas are more uncommon lesions.
  • The microscopic structure of tubulovillous adenoma has frond-like projection of mucosa with branching papillary structure and generally upward growth into the lumen.
  • We describe a 72-year-old man who showed aduodenal tubulovillous adenoma with unusual inverted cystic growth pattern.
  • Therefore, these findings argued that this adenoma arises from Brunner's glands through gastric metaplasia.
  • This is the first case of inverted cystic tubulovillous adenoma involving Brunner's glands of duodenum with gastric metaplasia.
  • [MeSH-major] Adenoma / pathology. Brunner Glands / pathology. Cysts / pathology. Duodenal Neoplasms / pathology

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  • (PMID = 17589910.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4436617
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51. Chetty R, Serra S: Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm. Histopathology; 2009 Sep;55(3):270-6
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  • [Title] Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm.
  • AIMS: Intraductal tubular adenoma (ITA) is an uncommon intraluminal polypoid lesion that occurs in the main pancreatic duct and involves the main pancreatic duct in the region of head or body.
  • Three cases of ITA are presented, the literature reviewed and their association with intraductal papillary mucinous neoplasm (IPMN) is postulated.
  • METHODS AND RESULTS: ITA is composed of tightly packed tubular structures with focal cystic dilation and papillary areas lined by gastric/pyloric epithelium showing minimal to mild cytological atypia.
  • ITA could represent a localized, polypoid form of gastric-type IPMN.It is a benign lesion with no evidence of invasion and no direct tumour-related deaths.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Adenoma / pathology. Carcinoma in Situ / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • [CommentIn] Histopathology. 2010 Jun;56(7):968-9; author reply 969 [20636797.001]
  • (PMID = 19723141.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Terao H, Matsumoto T, Umemoto S, Onuki T, Kobayashi K, Ohgo Y, Nogcchi S, Kishi H, Tsuura Y, Nagashima Y: [Metanephric adenoma: report of two cases]. Hinyokika Kiyo; 2008 Sep;54(9):599-602
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  • [Title] [Metanephric adenoma: report of two cases].
  • We report 2 cases of metanephric adenoma a rare form of adenoma.
  • Thus, the patient was diagnosed with metanephric adenoma.
  • In immunohistochemical staining, tumor cells were positive for CD57 and WT-1, and the patient was diagnosed with metanephric adenoma.
  • On angiography, they have a hypovascular pattern and resemble papillary renal carcinoma.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 18975573.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / WT1 Proteins
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53. Nara S, Shimada K, Kosuge T, Kanai Y, Hiraoka N: Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms. Am J Surg Pathol; 2008 Feb;32(2):243-55
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  • [Title] Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms.
  • Invasive intraductal papillary-mucinous carcinoma (I-IPMC) is a heterogeneous entity with various postoperative outcomes.
  • One hundred and four patients with intraductal papillary-mucinous neoplasm (IPMN) were clinicopathologically investigated.
  • The lesions were classified into 53 noninvasive IPMNs (adenoma, borderline, and noninvasive IPMC) and 51 I-IPMCs on the basis of the WHO classification.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenoma / mortality. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Survival Rate

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  • [CommentIn] Am J Surg Pathol. 2009 Feb;33(2):320-1; author reply 321-2 [18824892.001]
  • (PMID = 18223327.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Aravindakshan J, Chen X, Sairam MR: Differential expression of claudin family proteins in mouse ovarian serous papillary epithelial adenoma in aging FSH receptor-deficient mutants. Neoplasia; 2006 Dec;8(12):984-94
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  • [Title] Differential expression of claudin family proteins in mouse ovarian serous papillary epithelial adenoma in aging FSH receptor-deficient mutants.
  • To understand the consequences of loss of follicle-stimulating hormone receptor (FSH-R) signaling and to explore why the atrophic and anovulatory ovaries of follitropin receptor knockout (FORKO) mice develop different types of ovarian tumors, including serous papillary epithelial adenoma later in life, we used mRNA expression profiling to gain a comprehensive view of misregulated genes.
  • [MeSH-major] Adenoma / metabolism. Gene Expression Regulation, Neoplastic / physiology. Nerve Tissue Proteins / biosynthesis. Ovarian Neoplasms / metabolism. Receptors, FSH / deficiency

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  • (PMID = 17217615.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Claudin-1; 0 / Claudin-3; 0 / Claudin-4; 0 / Claudins; 0 / Cldn1 protein, mouse; 0 / Cldn11 protein, mouse; 0 / Cldn3 protein, mouse; 0 / Cldn4 protein, mouse; 0 / Membrane Proteins; 0 / Nerve Tissue Proteins; 0 / Receptors, FSH
  • [Other-IDs] NLM/ PMC1783714
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55. Handra-Luca A, Fléjou JF, Rufat P, Corcos O, Belghiti J, Ruszniewski P, Degott C, Bedossa P, Couvelard A: Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma. Histopathology; 2006 Jun;48(7):813-21
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  • [Title] Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma.
  • AIMS: To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs).
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Pancreatic Ductal / pathology. Cystadenoma, Mucinous / pathology. Cystadenoma, Papillary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 16722930.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT20 protein, human; 0 / Keratin-20; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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56. Cates JM, Williams TL, Suriawinata AA: Intraductal papillary mucinous adenoma that arises from pancreatic heterotopia within a meckel diverticulum. Arch Pathol Lab Med; 2005 Mar;129(3):e67-9
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  • [Title] Intraductal papillary mucinous adenoma that arises from pancreatic heterotopia within a meckel diverticulum.
  • Intraductal papillary mucinous neoplasms are relatively uncommon tumors of pancreatic ductal epithelial cells that line the main pancreatic duct or its major side branches.
  • We present an unusual case of an intraductal papillary mucinous neoplasm that arose in a heterotopic pancreas within a Meckel diverticulum.
  • [MeSH-major] Adenocarcinoma, Mucinous / etiology. Carcinoma, Ductal / etiology. Carcinoma, Papillary / etiology. Choristoma / complications. Duodenal Diseases / complications. Meckel Diverticulum / complications. Pancreas / pathology. Pancreatic Neoplasms / etiology


57. Nara S, Shimada K, Sakamoto Y, Esaki M, Kosuge T, Hiraoka N: Clinical significance of frozen section analysis during resection of intraductal papillary mucinous neoplasm: should a positive pancreatic margin for adenoma or borderline lesion be resected additionally? J Am Coll Surg; 2009 Nov;209(5):614-21
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  • [Title] Clinical significance of frozen section analysis during resection of intraductal papillary mucinous neoplasm: should a positive pancreatic margin for adenoma or borderline lesion be resected additionally?
  • BACKGROUND: The clinical significance of a positive intraoperative frozen section analysis of the pancreatic margin, especially for adenoma or borderline lesion, is not well understood during operations for intraductal papillary mucinous neoplasm of the pancreas.
  • STUDY DESIGN: Data from 130 consecutive patients who underwent intraductal papillary mucinous neoplasm resection in a single institution were retrospectively analyzed.
  • RESULTS: In the first intraoperative frozen section analysis, 26 patients were positive for adenoma or borderline lesion, 10 for carcinoma in situ, 2 for cancer cells floating in the duct, and 6 for invasive cancer.
  • Among 18 patients with a positive pancreatic margin for adenoma or borderline lesion, only 1 had a recurrence.
  • All 20 patients who suffered a recurrence harbored invasive intraductal papillary mucinous carcinoma in resected specimens.
  • In multivariate analysis, predictive factors of recurrence after intraductal papillary mucinous carcinoma resection were the presence of lymph node metastasis, serosal invasion, and a high level of serum carbohydrate antigen 19-9.
  • CONCLUSIONS: The presence of adenoma or borderline lesion at the pancreatic margin does not always warrant further resection because of the low recurrence rate in the remnant pancreas.
  • Recurrence after intraductal papillary mucinous neoplasm resection is influenced primarily by the presence and extent of invasive cancer rather than the status of the pancreatic margin.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Frozen Sections. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local

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  • (PMID = 19854402.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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58. Lee SH, Lee DS, You IY, Jeon WJ, Park SM, Youn SJ, Choi JW, Sung R: [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. Korean J Gastroenterol; 2010 Feb;55(2):119-26
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  • [Title] [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder].
  • BACKGROUND/AIMS: In order to determine the malignant potential of gallbladder adenoma for progression to carcinoma, we evaluated the histopathologic features of adenoma and adenoma-related lesions on cholecystectomized specimens.
  • METHODS: Among 1,847 cholecystectomized specimens, 63 specimens from 26 benign adenomas, 9 carcinomas in situ (CIS), and 28 invasive carcinomas were selected.
  • A pathologist reviewed all specimens and selected benign adenomas, CIS in the adenoma, and adenoma residue in invasive carcinomas.
  • Adenomas and adenoma-related lesions were classified according to morphology (tubular, tubulopapillary, and papillary) and the consisting epithelium (biliary, pyloric metaplasia, and intestinal metaplasia).
  • The age and the size of the benign adenomas and carcinomas in the adenoma were also compared.
  • RESULTS: Adenoma and adenoma-related lesions were found in 34 out (1.8%) of all resected gallbladder.
  • Among 9 CIS and 28 invasive carcinomas, adenoma-related lesions were detected in 7 and 1 case, respectively.
  • All eight carcinomas arising in the adenoma were well-differentiated solitary tumors.
  • The diameters of the carcinomas in the adenoma were, on average, larger than that of the benign adenomas (1.8 cm vs. 0.9 cm, p=0.01).
  • The patients with carcinomas in the adenoma were, on average, older than those with benign adenomas, although the difference was insignificant (57 years vs. 47 years, p=0.09).
  • The morphology and consisting epithelium did not differ between the benign adenomas and carcinomas in the adenoma.
  • The malignant transformation occurred in 23.5% of adenomas.
  • CONCLUSIONS: Gallbladder adenoma is a rare disease, although malignant transformation occurs frequently.
  • Adenoma is a precancerous lesion and the adenoma-carcinoma sequence is one of the gallbladder cancer carcinogenesis.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 20168058.001).
  • [ISSN] 2233-6869
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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59. Cashell AW: Apocrine adenoma of the breast. W V Med J; 2008 Mar-Apr;104(2):16-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine adenoma of the breast.
  • A case of apocrine adenoma, a rare benign tumor of the breast is reported.
  • Apocrine adenomas have been reported arising in a variety of sites including the breast, (1-5) perianal region, (6,7) eyelid, (8) and axilla. (9) Their appearance has similarities to the apocrine metaplasia commonly seen in fibrocystic change of the breast but they are well-circumscribed tumors with closely packed tubular and papillary structures.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Apocrine Glands / pathology. Breast Neoplasms / diagnosis

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  • (PMID = 18491794.001).
  • [ISSN] 0043-3284
  • [Journal-full-title] The West Virginia medical journal
  • [ISO-abbreviation] W V Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Wente MN, Schmied BM, Schmidt J, Büchler MW: [Differentiated therapy for intraductal papillary mucinous neoplasms]. Chirurg; 2009 Jan;80(1):7-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Differentiated therapy for intraductal papillary mucinous neoplasms].
  • Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are of increasing interest in the field of pancreatic surgery ever since their first description as an individual pancreatic tumor entity in 1982.
  • The decision for surgical or conservative management is based on the adenoma-carcinoma sequence and the differentiation into main-duct or branch-duct IPMN.
  • Invasive IPMN forms (carcinoma in situ and invasive carcinoma) and in particular noninvasive IPMNs (adenoma and borderline tumors) reveal significantly better survival rates than ductal adenocarcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Carcinoma, Papillary / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery

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  • (PMID = 19082569.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 50
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61. Okada K, Suzuki Y, Saito Y, Umemura S, Tokuda Y: Two cases of ductal adenoma of the breast. Breast Cancer; 2006;13(4):354-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two cases of ductal adenoma of the breast.
  • We encountered two cases of ductal adenoma of the breast.
  • On excisional biopsy of the largest , intraoperative pathological examination of frozen sections was suspicious for ductal carcinoma with a differential diagnosis of intraductal papilloma or intraductal papillary carcinoma.
  • Ductal adenoma was diagnosed after pathological examination of the permanent sections.
  • Ductal adenoma (sclerosing papilloma) with hemorrhagic infarction was diagnosed.
  • It is noteworthy that ductal adenoma have clinical and histopathological features that should be differentiated from carcinoma, especially when the tumor is accompanied by secondary changes such as hemorrhage or infarction.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology

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  • (PMID = 17146162.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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62. Takasu N, Kimura W, Moriya T, Takeshita A, Murayama S, Hirai I, Ogata S: A pancreatobiliary-type carcinoma in situ at the periphery of a mural nodule developed from a gastric adenoma in an intraductal papillary mucinous neoplasm. Clin J Gastroenterol; 2010 Aug;3(4):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A pancreatobiliary-type carcinoma in situ at the periphery of a mural nodule developed from a gastric adenoma in an intraductal papillary mucinous neoplasm.
  • We report a rare case of an intraductal papillary mucinous neoplasm (IPMN) with a pancreatobiliary-type carcinoma in situ (CIS) that originated around a mural nodule formed in a gastric-type adenoma.
  • Histopathologic examination showed an intraductal papillary mucinous carcinoma arising from an adenoma.

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  • (PMID = 26190249.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Growth pattern / Intraductal papillary mucinous neoplasm / Mural nodule / Subtype
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63. Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D: Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia. Acta Dermatovenerol Croat; 2007;15(3):148-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.
  • A case of a 79-year-old woman with axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia is presented.
  • It was predominantly composed of complex, closely packed tubuloglandular structures but in few areas papillary structures were also observed.
  • In one area, the tumor was lobular and composed of tubular structures lined with one layer of uniform cuboidal or columnar eosinophilic cells, indicating a pre-existing apocrine adenoma.
  • This and previously reported cases suggest that apocrine hyperplasia and apocrine adenoma may represent successive steps in the development of apocrine carcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17868540.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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64. Kuroki T, Tajima Y, Tsutsumi R, Mishima T, Kitasato A, Adachi T, Kanematsu T: Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma. Am J Surg; 2006 Jun;191(6):823-6
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  • [Title] Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma.
  • Intraductal papillary mucinous neoplasm (IPMN) of the pancreas showed significantly less aggressive pathologic features compared with common pancreatic cancer.

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  • (PMID = 16720158.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Okada Y, Arakaki R, Kitahara M, Terada N, Kaneko Y, Oomori K, Nishimura K: [Two cases of the nephrogenic adenoma of the bladder]. Hinyokika Kiyo; 2005 Jul;51(7):467-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two cases of the nephrogenic adenoma of the bladder].
  • Nephrogenic adenoma is a relatively rare, benign tumor of the urinary tract.
  • We experienced two cases of nephrogenic adenoma originating in the bladder.
  • Two papillary tumors were found on the bladder.
  • Cystoscopy showed a papillary tumor on the top of the bladder wall and TUR-Bt was performed.
  • In both cases, the histopathological diagnosis was the nephrogenic adenoma.
  • Our cases are the 40th and 41st cases of the nephrogenic adenoma of the bladder reported in the Japanese literature.
  • [MeSH-major] Adenoma / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16119812.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 17
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66. Miyasaka Y, Nagai E, Ohuchida K, Nakata K, Hayashi A, Mizumoto K, Tsuneyoshi M, Tanaka M: CD44v6 expression in intraductal papillary mucinous neoplasms of the pancreas. Pancreas; 2010 Jan;39(1):31-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD44v6 expression in intraductal papillary mucinous neoplasms of the pancreas.
  • OBJECTIVES: The purpose of this study was to examine CD44v6 expression in intraductal papillary mucinous neoplasms (IPMNs) and clarify the role of CD44v6 in progression, invasion, metastasis, and morphogenesis of IPMNs.
  • The IPMNs were divided into 4 groups according to the grade of atypia (adenoma, borderline IPMN, noninvasive carcinoma, and invasive carcinoma) and 5 subtypes according to histological phenotype (gastric, intestinal, pancreatobiliary, oncocytic, and unclassified).

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  • (PMID = 19952968.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / CD44v6 antigen
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67. Gourgiotis S, Ridolfini MP, Germanos S: Intraductal papillary mucinous neoplasms of the pancreas. Eur J Surg Oncol; 2007 Aug;33(6):678-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papillary mucinous neoplasms of the pancreas.
  • BACKGROUND/AIMS: Intraductal papillary mucinous neoplasms (IPMNs) are neoplasms of the pancreatic duct epithelium characterized by intraductal papillary growth and thick mucin secretion.
  • Most branch type IPMNs are benign, while the other two types are frequently malignant.
  • Presence of a large branch type IPMN and marked dilatation of the main duct indicate the existence of adenoma at least.
  • CONCLUSIONS: Prognosis is excellent after complete resection of benign and non-invasive malignant IPMNs.
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Dilatation, Pathologic / pathology. Humans. Prognosis

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  • (PMID = 17207960.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 76
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68. Nakagohri T, Kinoshita T, Konishi M, Takahashi S, Gotohda N: Surgical outcome of intraductal papillary mucinous neoplasms of the pancreas. Ann Surg Oncol; 2007 Nov;14(11):3174-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical outcome of intraductal papillary mucinous neoplasms of the pancreas.
  • OBJECTIVE: An increasing number of intraductal papillary mucinous neoplasms of the pancreas have been reported in recent years.
  • The objective of this study is to clarify the clinicopathologic features of intraductal papillary mucinous neoplasm of the pancreas and evaluate prognostic factors influencing survival.
  • METHODS: Eighty-two patients with intraductal papillary mucinous neoplasm undergoing surgical resection at the National Cancer Center Hospital East between April 1994 and October 2006 were retrospectively analyzed.
  • RESULTS: There were 31 patients with adenoma and 51 patients with carcinoma.
  • The 5-year survival rate for patients with intraductal papillary mucinous adenoma, noninvasive carcinoma, minimally invasive carcinoma, and invasive carcinoma was 80%, 78%, 83%, and 24%, respectively.
  • Regardless of the margin status, no patient with adenoma developed recurrent disease.
  • CONCLUSIONS: Patients with intraductal papillary mucinous adenoma, noninvasive carcinoma, and minimally invasive carcinoma showed favorable survival.
  • In contrast, invasive intraductal papillary mucinous carcinoma was associated with poor survival regardless of the margin status.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Biopsy, Needle. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 17694416.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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69. Bezić J, Forempoher G, Poljicanin A, Gunjaca G: Apocrine adenoma of the breast coexistent with invasive carcinoma. Pathol Res Pract; 2007;203(11):809-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine adenoma of the breast coexistent with invasive carcinoma.
  • We describe a case of apocrine adenoma with simultaneous occurrence of invasive ductal carcinoma in the breast of a 53-year-old woman.
  • Apocrine adenoma affecting the breast is very rare.
  • The lesion is composed of back-to-back ducts and papillary fronds covered with apocrine cells, and it is sharply demarcated from the surrounding breast tissue.
  • Histologic examination of the excised specimen showed that the hypoechogenic nodule represented an apocrine adenoma in proximity to the invasive ductal breast carcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17936522.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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70. Zhu XL, Zhou XY, Zhu XZ: [BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2005 May;34(5):270-4
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  • [Title] [BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma].
  • OBJECTIVE: To detect the BRAF(V599E) mutation and the RET/PTC chimeric gene in benign and malignant thyroid diseases and to explore their correlation with the clinicopathologic features of papillary thyroid carcinoma (PTC).
  • METHODS: PCR and RT-PCR were employed to detect BRAF(V599E) mutation and RET/PTC chimeric genes in 95 frozen and parraffine-embeded thyroid tissue. RESULTS:.
  • However, follicular types of PTC and other benign and malignant thyroid diseases were negative for BRAF(V599E) mutation. (2) Fourteen (21.2%) PTC cases expressed RET/PTC chimeric gene.
  • [MeSH-major] Carcinoma, Papillary / genetics. Oncogene Proteins, Fusion / genetics. Point Mutation. Protein-Tyrosine Kinases / genetics. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Adenoma / genetics. Adenoma / pathology. Adolescent. Adult. Aged. Diagnosis, Differential. Female. Gene Rearrangement. Hashimoto Disease / genetics. Hashimoto Disease / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged

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  • (PMID = 16181547.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / ret-PTC fusion oncoproteins, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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71. Dubova EA, Shchegolev AI: [Clinical and morphological characteristics of intraductal papillary mucinous tumors of the pancreas]. Arkh Patol; 2009 Mar-Apr;71(2):9-12
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  • [Title] [Clinical and morphological characteristics of intraductal papillary mucinous tumors of the pancreas].
  • The paper presents the results of a comprehensive morphological study of the surgical material from 5 patients (males aged 49 to 69 years) with intraductal papillary mucinous tumors (IDPMT) of the pancreas.
  • The pancreatobiliary type of IDPMT was established in 4 cases (one adenoma from the peripheral branches of the pancreatic duct, one IDPMT with the borderline malignancy potential from the major pancreatic duct, and two intraductal papillary mucinous carcinomas from the major pancreatic duct).
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenoma / metabolism. Adenoma / pathology. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / pathology

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  • (PMID = 19507570.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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72. Kumar PV, Shirazi M, Salehi M: A diagnostic pitfall of fine needle aspiration cytology in testicular papillary serous cyst adenoma: a case report. Acta Cytol; 2009 Jul-Aug;53(4):467-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A diagnostic pitfall of fine needle aspiration cytology in testicular papillary serous cyst adenoma: a case report.
  • FNA cytology findings revealed numerous papillary clusters, glandular-like structures and many isolated round cells.
  • Metastatic papillary adenocarcinoma was suspected based on FNAB cytology.
  • A right radical orchiectomy was performed, and histologic tissue examination was used to diagnose the tumor as a benign papillary serous cystadenoma.
  • CONCLUSION: Papillary serous cystadenoma of the testis is a rare tumor.
  • [MeSH-major] Biopsy, Fine-Needle. Cystadenoma, Papillary / pathology. Cystadenoma, Serous / pathology. Testicular Neoplasms / pathology

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  • (PMID = 19697740.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Surendran K, Selassie M, Liapis H, Krigman H, Kopan R: Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol; 2010 May;21(5):819-32
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reduced Notch signaling leads to renal cysts and papillary microadenomas.
  • Moreover, a few stratified foci/microadenomas containing hyperproliferative cells, resembling precursors of papillary renal cell carcinoma, formed in these proximal tubules.
  • Furthermore, post hoc analysis of human class 1 papillary renal cell carcinoma revealed reduced Notch activity in these tumors, resulting from abundant expression of a potent inhibitor of canonical Notch signaling, KyoT3/FHL1B.

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  • (PMID = 20378824.001).
  • [ISSN] 1533-3450
  • [Journal-full-title] Journal of the American Society of Nephrology : JASN
  • [ISO-abbreviation] J. Am. Soc. Nephrol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK066408; United States / NIDDK NIH HHS / DK / 5P30DK07933; United States / NIDDK NIH HHS / DK / DK066408
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / FHL1 protein, human; 0 / HEY1 protein, human; 0 / Hnf1b protein, mouse; 0 / Intracellular Signaling Peptides and Proteins; 0 / LIM Domain Proteins; 0 / Muscle Proteins; 0 / Receptors, Notch; 138674-15-4 / Hepatocyte Nuclear Factor 1-beta
  • [Other-IDs] NLM/ PMC2865744
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74. Iakovou IP, Konstantinidis IE, Chrisoulidou AI, Doumas AS: Synchronous parathyroid adenoma and thyroid papillary carcinoma: a case report. Cases J; 2009;2:9121

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous parathyroid adenoma and thyroid papillary carcinoma: a case report.
  • FNA of the thyroid nodule was positive for papillary carcinoma later verified by postoperative histopathology.This case underlines the need for a clinical high index of suspicion for synchronous hyperparathyroidism and thyroid cancer.

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  • (PMID = 20062698.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803918
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75. Obulareddy SJ, Xin J, Truskinovsky AM, Anderson JK, Franklin MJ, Dudek AZ: Metanephric adenoma of the kidney: an unusual diagnostic challenge. Rare Tumors; 2010;2(2):e38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metanephric adenoma of the kidney: an unusual diagnostic challenge.
  • Although metanephric adenoma (MA) is a rare, benign neoplasm of epithelial cells, it is often difficult to distinguish this entity from other malignant neoplasms preoperatively.
  • We report a case of a large renal mass for which preoperative diagnosis was indeterminate, with the differential diagnosis including Wilm's tumor, MA, and papillary renal cell carcinoma (PRCC).

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  • (PMID = 21139840.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994510
  • [Keywords] NOTNLM ; Wilm’s tumor / differential diagnosis. / metanephric adenoma / papillary renal cell carcinoma
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76. Bradly DP, Reddy V, Prinz RA, Gattuso P: Incidental papillary carcinoma in patients treated surgically for benign thyroid diseases. Surgery; 2009 Dec;146(6):1099-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidental papillary carcinoma in patients treated surgically for benign thyroid diseases.
  • BACKGROUND: The frequency of incidental papillary carcinoma (IPC) has been reported to be between 4.6 % and 10% in operatively treated benign thyroid diseases.
  • This study reviews the occurrence of IPC in thyroid glands removed for benign disease at our institution.
  • METHODS: Six hundred and seventy-eight patients underwent partial or total thyroidectomy for benign thyroid diseases.
  • The incidence of IPC was compared among patients with Hashimoto's thyroiditis, multinodular goiter, follicular adenoma, and Graves' disease.
  • RESULTS: Overall, 81 (12.0%) IPCs were recorded with decreasing order of frequency: Hashimoto's thyroiditis, follicular adenoma, goiter, and Graves' disease.
  • Contralateral IPC was detected in 6/15 (40%) patients with follicular adenoma.
  • CONCLUSION: The overall incidence of IPC in benign operatively resected thyroid disease was 12%.
  • IPC was encountered in the contralateral lobe in 40% of patients with follicular adenoma.
  • Total thyroidectomy may be considered an appropriate operative treatment in patients with Hashimoto's thyroiditis and follicular adenoma requiring operation owing to the high incidence and frequent contralateral involvement of IPC, respectively.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Thyroid Diseases / surgery. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Chicago / epidemiology. Female. Goiter, Nodular / complications. Goiter, Nodular / surgery. Graves Disease / complications. Graves Disease / surgery. Hashimoto Disease / complications. Hashimoto Disease / surgery. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / surgery. Thyroidectomy. Young Adult

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  • (PMID = 19958937.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Al-Refaie WB, Choi EA, Tseng JF, Tamm EP, Lee JH, Lee JE, Evans DB, Pisters PW: Intraductal papillary mucinous neoplasms of the pancreas. Med Princ Pract; 2006;15(4):245-52
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  • [Title] Intraductal papillary mucinous neoplasms of the pancreas.
  • The introduction of the exocrine pancreatic classification by the World Health Organization and improvements in pancreatic imaging have led to an improved understanding of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas.
  • IPMNs are characterized by the cystic dilatation of the pancreatic duct and its branches, with papillary projections.
  • The degree of atypia ranges from adenoma to frank invasive carcinoma.

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 16763389.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 29
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78. Pisello F, Geraci G, Sciumè C, Li Volsi F, Modica G: [Total thyroidectomy of choice in papillary microcarcinoma]. G Chir; 2007 Jan-Feb;28(1-2):13-9
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  • [Title] [Total thyroidectomy of choice in papillary microcarcinoma].
  • [Transliterated title] La tiroidectomia totale di principio nel microcarcinoma papillare.
  • INTRODUCTION: Today, the "gold standard" of surgical management of benign thyroid disease is still controversy.
  • In consideration of the more frequent incidence of small carcinomas accidentally founded in the context of the thyroid parenchyma removed for another pathology, the aim of this study is to bring a contribute to resolve the debate on the therapeutic choice in the surgical management of the thyroid benign disease.
  • RESULTS: After total thyroidectomy in 17 patients (3.4%) we founded a papillary incidental "microcarcinoma", diameter range 2-10 mm (mean 6.9 mm).
  • Histologically, were 11 cases of classical papillary (64.7%), 4 cases (23.6%) of follicular and 2 (11.7%) sclerosing, in 9 cases of multinodular goiter, 3 of follicular adenoma, 3 cases of follicular carcinoma, 1 case of Graves disease and 1 case of Hashimoto thyroiditis.
  • DISCUSSION: Papillary microcarcinoma is a "thyroid papillary cancer with a diameter < or = 1 cm? ".
  • From the analysis of literature, we observed a progressive increasing of papillary microcarcinoma from 12% (1980) to 25% (1990), with a prevalence of diameters < or = 5.
  • CONCLUSIONS: In our opinion, the surgical management of the all thyroid disease must be the more radical since the first time, because we think other approaches not correct to improve the complete health from the benign thyroid disease and to prevent (secondary prevention) papillary microcarcinoma not pre-operative diagnosed, because there are no preoperative pattern to make a correct diagnosis of this tumour.
  • [MeSH-major] Carcinoma, Papillary / surgery. Thyroid Neoplasms / surgery. Thyroidectomy / methods

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  • (PMID = 17313727.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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79. Allen PJ: The management of intraductal papillary mucinous neoplasms of the pancreas. Surg Oncol Clin N Am; 2010 Apr;19(2):297-310
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The management of intraductal papillary mucinous neoplasms of the pancreas.
  • Intraductal papillary mucinous neoplasms (IPMN) are mucinous cystic tumors of the pancreas, which were first classified into a unified diagnosis by the World Health Organization in 1996.
  • IPMN encompasses a spectrum of precursor lesions, from adenoma to intraductal carcinoma to invasive cancer, with molecular data supporting the premise that this dysplastic process has the potential to progress from low-grade dysplasia to invasive carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / therapy. Carcinoma, Pancreatic Ductal / therapy. Carcinoma, Papillary / therapy. Pancreatic Neoplasms / therapy

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  • (PMID = 20159516.001).
  • [ISSN] 1558-5042
  • [Journal-full-title] Surgical oncology clinics of North America
  • [ISO-abbreviation] Surg. Oncol. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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80. Rahemtullah A, Oliva E: Nephrogenic adenoma: an update on an innocuous but troublesome entity. Adv Anat Pathol; 2006 Sep;13(5):247-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nephrogenic adenoma: an update on an innocuous but troublesome entity.
  • Nephrogenic adenoma (NA) is a rare benign lesion of the urothelial tract that is typically preceded by some form of genitourinary insult.
  • On light microscopy, NA shows a variety of patterns, including tubulocystic, papillary, and much less frequently solid, that often coexist.
  • [MeSH-major] Adenoma / pathology. Urologic Neoplasms / pathology

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  • (PMID = 16998318.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 64
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81. Ikenaga N, Ohuchida K, Mizumoto K, Yu J, Kayashima T, Hayashi A, Nakata K, Tanaka M: Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas. Hum Pathol; 2010 Oct;41(10):1466-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas.
  • The aims of this study were (1) to evaluate the association between CD24 expression and the progression of intraductal papillary mucinous neoplasms of the pancreas and (2) to investigate the association between CD24 expression in pancreatic cancer and the prognosis of patients who underwent curative pancreatectomy.
  • Immunohistochemical analysis of CD24 was performed for 95 intraductal papillary mucinous neoplasms of the pancreas and 83 pancreatic cancers.
  • We investigated the association between CD24 expression and the histologic grade of intraductal papillary mucinous neoplasms of the pancreas, the clinicopathologic parameters of pancreatic cancers, and the survival time of pancreatic cancer patients who underwent pancreatectomy.
  • The positive rates of CD24 expression in intraductal papillary mucinous adenoma, borderline intraductal papillary mucinous neoplasm, noninvasive intraductal papillary mucinous carcinoma, and invasive intraductal papillary mucinous carcinoma were 5 (20%) of 24, 12 (48%) of 25, 10 (43%) of 23, and 15 (65%) of 23, respectively.
  • The CD24-positive rates were significantly higher in borderline intraductal papillary mucinous neoplasm and intraductal papillary mucinous carcinoma compared with intraductal papillary mucinous adenoma (P = .046 and P = .007, respectively).
  • The staining scores, which were determined from the percentage of stained cells and the staining intensity, were significantly higher in invasive intraductal papillary mucinous carcinoma than in noninvasive intraductal papillary mucinous carcinoma (P = .043).
  • In conclusion, CD24 is involved in the progression of intraductal papillary mucinous neoplasms of the pancreas and in the malignant behavior of pancreatic cancers.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Antigens, CD24 / biosynthesis. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Papillary / metabolism. Pancreatic Neoplasms / metabolism

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20619441.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD24
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82. Nakata K, Nagai E, Ohuchida K, Aishima S, Hayashi A, Miyasaka Y, Yu J, Mizumoto K, Tanaka M, Tsuneyoshi M: REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms. Mod Pathol; 2009 Mar;22(3):460-8
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  • [Title] REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms.
  • Subclassification of intraductal papillary mucinous neoplasms of the pancreas (IPMNs), based on morphological features and immunohistochemical profiles, has been proposed.
  • Regenerating islet-derived family, member 4 (REG4) is associated with the adenoma-carcinoma sequence in colon cancer and it is also associated with intestinal phenotype.
  • REG4 expression was observed more frequently in borderline lesions (14/28) and carcinoma (21/45) compared to adenoma (8/52).
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / pathology. Biomarkers, Tumor / analysis. Gene Expression. Homeodomain Proteins / biosynthesis. Homeodomain Proteins / genetics. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Microdissection. Mucin-2 / biosynthesis. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19136934.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Lectins, C-Type; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / REG4 protein, human; 0 / RNA, Messenger
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83. Yamada Y, Fujimura T, Takahashi S, Takeuchi T, Takazawa Y, Kitamura T: Tubulovillous adenoma developing after urinary reconstruction using ileal segments. Int J Urol; 2006 Aug;13(8):1134-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubulovillous adenoma developing after urinary reconstruction using ileal segments.
  • A case of tubulovillous adenoma arising in an augmented bladder is described.
  • Cystoscopy revealed a non-papillary multiple tumor at the site of ileovesical anastomosis and transurethral resection biopsy was performed.
  • Histopathological examination revealed a tubulovillous adenoma.
  • A tubulovillous adenoma developing at the augmented bladder is rare.
  • To our knowledge, this is the second case in which a tubulovillous adenoma developed in an augmented bladder.
  • [MeSH-major] Adenoma, Villous / etiology. Urinary Bladder / surgery. Urinary Bladder Neoplasms / etiology. Urinary Reservoirs, Continent

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  • (PMID = 16903947.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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84. Albores-Saavedra J, Wu J: The many faces and mimics of papillary thyroid carcinoma. Endocr Pathol; 2006;17(1):1-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The many faces and mimics of papillary thyroid carcinoma.
  • This article provides an overview of the 15 histologic variants of papillary thyroid carcinoma listed by the 2004 World Health Organization (WHO) monograph on endocrine tumors.
  • The follicular variants (conventional and macrofollicular) constitute a morphologic challenge because the majority of these tumors are encapsulated and, also, because, in many tumors, not all neoplastic cells show the nuclear features considered to be diagnostic of papillary carcinoma.
  • Moreover, hyperplastic thyroid lesions, follicular adenomas, and Hashimoto's thyroiditis may contain cells with clear nuclei resembling those of papillary carcinoma.
  • Papillary carcinomas composed entirely of hyperchromatic cells have been overlooked.
  • The WHO monograph defines papillary carcinoma with focal spindle and giant cell carcinoma components but its clinical behavior is unknown.
  • Papillary carcinoma with an insular pattern that does not show the artifactual separation of the cell nests has been misinterpreted as the solid variant of papillary carcinoma.
  • Papillary microcarcinomas include not only the conventional type and the follicular variants but also the tall cell and columnar cell variants.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenoma / diagnosis. Cell Nucleus / pathology. Diagnosis, Differential. Hashimoto Disease / diagnosis. Humans. Hyperplasia / diagnosis. Thyroid Gland / pathology. World Health Organization

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  • (PMID = 16760576.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 68
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85. Tamahashi U, Kumagai J, Takizawa T, Sekine M, Eishi Y: Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas. Virchows Arch; 2008 Jul;453(1):79-87
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  • [Title] Expression and intracellular localization of matrix metalloproteinases in intraductal papillary mucinous neoplasms of the pancreas.
  • To analyze the expression of matrix metalloproteinases (MMPs) and their relationships with the histological grades of the intraductal papillary mucinous neoplasm (IPMN) of the pancreas, we examined the frequency of expression and intracellular localization of MMP1, MMP2, MMP3, MMP7, and MMP9 in IPMN by immunohistochemistry.
  • A total of 45 IPMN lesions (14 adenomas, 17 borderline lesions, nine noninvasive carcinomas, and five invasive lesions) from 21 patients were examined.
  • Frequency of tumor cells expressing MMP7 was low in adenomas (median, 5.0%), higher in borderline lesions (median, 30.0%), in noninvasive carcinomas (median, 50.0%), and in invasive lesions (median, 80.0%), with a significant trend (P < 0.0001).
  • MMP7 may contribute to the process by which IPMN advances from adenoma to carcinoma and to subsequent invasion of tumor cells in IPMN.
  • [MeSH-major] Adenocarcinoma, Mucinous / metabolism. Adenoma / metabolism. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Papillary / metabolism. Matrix Metalloproteinases / metabolism. Pancreatic Neoplasms / metabolism

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  • (PMID = 18500535.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cadherins; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.7 / Matrix Metalloproteinase 1
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86. Yaman B, Nart D, Yilmaz F, Coker A, Zeytunlu M, Kilic M: Biliary intraductal papillary mucinous neoplasia: three case reports. Virchows Arch; 2009 May;454(5):589-94
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  • [Title] Biliary intraductal papillary mucinous neoplasia: three case reports.
  • Intraductal-growing type is an entity described in recent years as mucin-producing intrahepatic cholangiocarcinoma or intrahepatic (biliary) intraductal papillary mucinous neoplasia (b-IPMN).
  • b-IPMN is classified as adenoma, borderline tumor, carcinoma in situ, and carcinoma, from benign to malignant.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Papillary / pathology. Cholangiocarcinoma / pathology

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  • (PMID = 19347361.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1
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87. Tong GX, Melamed J, Mansukhani M, Memeo L, Hernandez O, Deng FM, Chiriboga L, Waisman J: PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol; 2006 Mar;19(3):356-63
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  • [Title] PAX2: a reliable marker for nephrogenic adenoma.
  • Nephrogenic adenoma is a rare lesion of the urinary tract.
  • It recently was demonstrated that nephrogenic adenoma in renal transplant patients originated from the renal tubular epithelium.
  • This newly proved, but long sought information may be helpful in the differential diagnosis of nephrogenic adenoma.
  • In this study, we investigated the expression of a renal transcription factor, PAX2, in 39 nonrenal transplant-related nephrogenic adenomas, 100 adenocarcinomas of the prostate gland, and 47 urothelial carcinomas of the urinary tract.
  • A strong and distinct nuclear staining of PAX2 was found in all 39 cases of nephrogenic adenoma (100%), but not in normal prostate tissue, normal urothelium, adenocarcinomas of the prostate gland, and invasive urothelial carcinomas.
  • Focal CD10 was detected in six of 13 nephrogenic adenomas in the superficial papillary component and in normal prostate epithelium, normal urothelium, lymphocytes, adenocarcinoma of the prostate gland, and urothelial carcinoma.
  • There was no uroplakins detected in nephrogenic adenoma.
  • Therefore, these findings are suggesting that nephrogenic adenoma in nonrenal transplant patients may also arise from the renal epithelium, as did the comparable lesions after transplantation.
  • PAX2 is a specific and sensitive immunohistochemical marker in identification and differential diagnosis of nephrogenic adenoma.
  • [MeSH-major] Adenoma / pathology. Biomarkers, Tumor / analysis. PAX2 Transcription Factor / analysis. Urologic Neoplasms / pathology

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  • (PMID = 16400326.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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88. Farnell MB: Surgical management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. J Gastrointest Surg; 2008 Mar;12(3):414-6
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  • [Title] Surgical management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
  • Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is characterized by papillary growths within the pancreatic ductal system that are at risk for undergoing malignant transformation.
  • [MeSH-major] Adenoma / surgery. Carcinoma in Situ / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery. Precancerous Conditions / surgery
  • [MeSH-minor] Carcinoma, Papillary / surgery. Diagnostic Imaging. Dilatation, Pathologic. Humans. Pancreatic Ducts / pathology. Pancreaticoduodenectomy

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  • (PMID = 17968632.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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89. Matusan K, Dordevic G, Mozetic V, Lucin K: Expression of osteopontin and CD44 molecule in papillary renal cell tumors. Pathol Oncol Res; 2005;11(2):108-13
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  • [Title] Expression of osteopontin and CD44 molecule in papillary renal cell tumors.
  • The aim of the study was to analyze the expression of CD44 adhesion molecule and its ligand osteopontin in papillary renal cell tumors, and to assess the possible prognostic significance of CD44 and osteopontin expression in papillary renal cell carcinomas.
  • The expression of the standard and v6 exon containing isoforms of CD44 molecule, as well as of its ligand osteopontin, was immunohistochemically evaluated in 43 papillary renal cell tumors, which included 5 adenomas and 38 carcinomas.
  • In order to assess their prognostic significance, the results obtained in papillary renal cell carcinomas were compared to usual clinicopathological parameters such as tumor size, histological grade, pathological stage, and Ki-67 proliferation index.
  • Papillary renal cell adenomas were generally negative for CD44s, except for focal positivity found in one sample.
  • The osteopontin protein was detected in all adenomas and all papillary renal cell carcinomas, except one.
  • Our results show constitutive expression of osteopontin in papillary renal tumors, including papillary renal cell adenomas.
  • The upregulation of CD44s and v6 isoforms, although found in a considerable number of papillary renal cell carcinomas, does not appear to have any prognostic value in this type of renal cancer.
  • [MeSH-major] Antigens, CD44 / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Papillary / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Sialoglycoproteins / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Female. Humans. Kidney / metabolism. Kidney / pathology. Male. Neoplasm Staging. Osteopontin

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  • (PMID = 15999156.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin
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90. Lin SD, Tu ST, Hsu SR, Chang JH, Yang KT, Yang LH: Synchronous parathyroid and papillary thyroid carcinoma. J Chin Med Assoc; 2005 Feb;68(2):87-91
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  • [Title] Synchronous parathyroid and papillary thyroid carcinoma.
  • The resected specimens were pathologically identified as papillary thyroid carcinoma and parathyroid carcinoma, respectively.
  • Although parathyroid carcinoma is an uncommon cause of parathyroid hormone-dependent hypercalcemia, it should nonetheless be given due consideration because its surgical approach differs from that of parathyroid adenoma.
  • [MeSH-major] Carcinoma, Papillary / complications. Neoplasms, Multiple Primary / complications. Parathyroid Neoplasms / complications. Thyroid Neoplasms / complications

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  • (PMID = 15759821.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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91. Elsheikh TM, Asa SL, Chan JK, DeLellis RA, Heffess CS, LiVolsi VA, Wenig BM: Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma. Am J Clin Pathol; 2008 Nov;130(5):736-44
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  • [Title] Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma.
  • Distinguishing follicular variant of papillary carcinoma (FVPC) from follicular adenoma and follicular carcinoma can be difficult if nuclear features of papillary carcinoma are not well developed or only focally present.
  • Unanimous agreement on benign and malignant diagnoses was seen in 4 cases (27%) and majority agreement on malignancy in 8 cases (53%).
  • [MeSH-major] Carcinoma, Papillary, Follicular / diagnosis. Carcinoma, Papillary, Follicular / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / pathology. Adenoma / diagnosis. Adenoma / pathology. Adult. Cell Nucleus / pathology. Diagnostic Errors / prevention & control. Female. Humans. Male. Middle Aged. Observer Variation. Pathology, Surgical / standards

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  • [CommentIn] Am J Clin Pathol. 2008 Nov;130(5):683-6 [18854259.001]
  • (PMID = 18854266.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Kefeli M, Akpolat I, Yildirim A, Sunter AT, Kandemir B: Morphometric analysis in cytologic evaluation of papillary thyroid carcinoma. Anal Quant Cytol Histol; 2010 Aug;32(4):234-8
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  • [Title] Morphometric analysis in cytologic evaluation of papillary thyroid carcinoma.
  • OBJECTIVE: To compare the morphometric features of papillary carcinomas with follicular neoplasias and benign lesions and to determine the potential role of nuclear morphometric features in their differential diagnosis.
  • STUDY DESIGN: Morphometric features were investigated in the cytologic samples of 64 cases, including 27 benign lesions, 6 follicular neoplasias and 31 papillary carcinomas.
  • RESULTS: There were no significant differences between the benign lesion and follicular neoplasia groups for any nuclear parameters.
  • However, between benign lesions and papillary carcinomas, there were significant differences for all parameters, except for form factor.
  • Between follicular neoplasms and papillary carcinomas, only the MaxD/MinD ratio was significantly different.
  • CONCLUSION: The results of this study indicate that the ratio of MaxD/MinD is a distinct nuclear morphometric feature for distinguishing papillary carcinoma from other thyroid lesions, and it may be employed with other cytologic criteria in diagnosing problematic cases.

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  • (PMID = 21434525.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Shih CM, Wu SC, Lee CC, Pan CC: Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis. J Chin Med Assoc; 2007 Jan;70(1):33-5

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  • [Title] Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis.
  • Villous adenoma is most frequently found in the colon and rectum, seldom in the urinary tract and even more rarely in the ureter or pelvis.
  • Ureteroscopy revealed papillary tumor obstructing the upper third of the ureter and inducing hydroureteronephrosis with abundant mucoid content.
  • The ureteral tumor proved to be villous adenoma by pathologic examination.
  • It should be noted that ureteral villous adenoma may be related to previous enteric-type metaplastic mucosa or ureteritis glandularis, demonstrates profuse production of mucus, and may eventually undergo malignant transformation.
  • [MeSH-major] Adenoma, Villous / complications. Hydronephrosis / etiology. Ureteral Neoplasms / complications

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  • (PMID = 17276931.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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94. Gross M, Eliashar R, Ben-Yaakov A, Weinberger JM, Maly B: Clinicopathologic features and outcome of the oncocytic variant of papillary thyroid carcinoma. Ann Otol Rhinol Laryngol; 2009 May;118(5):374-81
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  • [Title] Clinicopathologic features and outcome of the oncocytic variant of papillary thyroid carcinoma.
  • OBJECTIVES: The purpose of this study was to define the clinicopathologic features and outcome of the oncocytic variant of papillary thyroid carcinoma (OVPTC) with a review of the literature.
  • CONCLUSIONS: OVPTC is a unique variant of papillary thyroid carcinoma that has distinctive clinicopathologic features.
  • Since OVPTC is often associated with local invasion and may involve cervical lymph nodes, it may require more extensive surgery than classic papillary thyroid carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 19548388.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Tabriz HM, Adabi Kh, Lashkari A, Heshmat R, Haghpanah V, Larijani B, Tavangar SM: Immunohistochemical analysis of nm23 protein expression in thyroid papillary carcinoma and follicular neoplasm. Pathol Res Pract; 2009;205(2):83-7
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  • [Title] Immunohistochemical analysis of nm23 protein expression in thyroid papillary carcinoma and follicular neoplasm.
  • INTRODUCTION: We aimed at assessing the significance of nm23 gene expression in papillary and follicular carcinomas, the two most common differentiated thyroid carcinomas.
  • MATERIALS AND METHODS: During a cross-sectional study, 173 paraffin blocks, including 131 papillary thyroid carcinomas, 12 follicular carcinomas and 30 follicular adenomas were stained with nm23 marker by immunohistochemistry method.
  • RESULTS: nm23 was positive in 40% of the follicular adenoma, 67.2% of the papillary carcinoma and 66.7% of the follicular carcinoma. p value was more than 0.05 in the assessment of the relationship between nm23 and all of the above-mentioned parameters in differentiated thyroid carcinomas. nm23 expression did not significantly differentiate between follicular adenoma and carcinoma.
  • Also, nm23 cannot be considered as a useful marker for the evaluation of invasion in differentiated thyroid carcinomas or in distinctions between follicular adenoma and carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Papillary / metabolism. Adenoma / metabolism. NM23 Nucleoside Diphosphate Kinases / biosynthesis. Thyroid Neoplasms / metabolism

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  • (PMID = 18996649.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6 / NME1 protein, human
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96. Turki ZM, Hajri H, Zrig N, Kourda N, Ferjaoui M, Ben Slama C: [Toxic nodular goitre associated with papillary thyroid carcinoma and primary hyperparathyroidism]. Rev Laryngol Otol Rhinol (Bord); 2006;127(4):239-42
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  • [Title] [Toxic nodular goitre associated with papillary thyroid carcinoma and primary hyperparathyroidism].
  • [Transliterated title] Association d'un goitre multinodulaire toxique, d'un carcinome papillaire de la thyroïde, et d'une hyperparathyroïdie primaire.
  • The association of a toxic multinodular goitre with papillary thyroid carcinoma and primary hyperparathyroidism is very rare.
  • The diagnosis of primary hyperparathyroidism was made following renal complications and the discovery of papillary thyroid carcinoma was incidental during the surgical treatment of parathyroid adenoma.
  • The fortuitous discovery of papillary thyroid carcinoma during parathyroid surgery has already been reported but in most cases it is a microcarcinoma.
  • The association of primary hyperparathyroidism, hyperthyroidism and papillary carcinoma of the thyroid is rare.
  • [MeSH-major] Carcinoma, Papillary / epidemiology. Goiter, Nodular / epidemiology. Thyroid Neoplasms / epidemiology

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  • (PMID = 17315788.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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97. Hopper AD, Bourke MJ, Williams SJ, Swan MP: Giant laterally spreading tumors of the papilla: endoscopic features, resection technique, and outcome (with videos). Gastrointest Endosc; 2010 May;71(6):967-75
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  • BACKGROUND: Successful endoscopic treatment of conventional papillary adenomas is well described.
  • INTERVENTION: Pre-resection staging and single-session endoscopic removal of papillary adenomas.
  • MAIN OUTCOME MEASUREMENTS: Technical success, complications, and adenoma recurrence for single-session removal of LST-P.
  • Outcomes were compared with those of conventional ampullary adenoma resection during the same period.
  • RESULTS: Twenty-five patients with ampullary adenomas were referred.
  • In 10 patients identified with LST-P (mean age 70.2 years; adenoma size 30-80 mm), combination EMR and papillectomy was performed in a single session.
  • Adenoma recurrence at 3 months was found in 1 patient (10%).
  • Complication and recurrence rates in smaller (<30 mm) ampullary adenoma resections were not significantly different.
  • In experienced hands, the outcomes are comparable to those for conventional ampullary adenomas.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Ampulla of Vater. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / surgery

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  • [Copyright] 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • [CommentIn] Endoscopy. 2011 Jan;43(1):42-6 [21234840.001]
  • (PMID = 20226451.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Anderson CE, Graham C, Herriot MM, Kamel HM, Salter DM: CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto's thyroiditis. Histopathology; 2009 Dec;55(6):683-6
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  • [Title] CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto's thyroiditis.
  • METHODS AND RESULTS: One hundred and forty thyroid cases were selected from the archives of the Department of Pathology, including normal controls, neoplasms (follicular adenoma, follicular carcinoma and papillary carcinoma) and non-neoplastic conditions (multinodular goitre, Graves' disease and Hashimoto's thyroiditis).
  • A similar pattern of expression was seen in follicular adenoma, minimally invasive follicular carcinoma, multinodular goitre and Graves' disease.
  • In most cases of papillary carcinoma and in the inflamed areas of Hashimoto's thyroiditis, expression of CD98 was decreased.
  • CONCLUSIONS: CD98 expression is down-regulated in thyroid papillary carcinoma; this may relate to the better prognosis associated with many of these tumours.
  • [MeSH-major] Antigens, CD98 / metabolism. Carcinoma, Papillary / metabolism. Hashimoto Disease / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. Down-Regulation. Graves Disease / metabolism. Humans. Immunohistochemistry. Prognosis

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  • (PMID = 19922591.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD98
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99. Augustin T, Vandermeer TJ: Intraductal papillary mucinous neoplasm: a clinicopathologic review. Surg Clin North Am; 2010 Apr;90(2):377-98

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  • [Title] Intraductal papillary mucinous neoplasm: a clinicopathologic review.
  • Intraductal papillary mucinous neoplasm (IPMN) is an intraductal mucin-producing epithelial neoplasm that arises from the main pancreatic duct (MD-IPMN), secondary branch ducts (BD-IPMN), or both (mixed type; Mix-IPMN).
  • Neoplastic progression from benign adenoma to invasive adenocarcinoma has not been proven but is generally thought to occur.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology

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  • (PMID = 20362793.001).
  • [ISSN] 1558-3171
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 96
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100. Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R: Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology; 2009;41(4):372-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammary-like gland adenoma of the vulva: review of 46 cases.
  • AIMS: Hidradenoma papilliferum (HP) of the anogenital region, which was previously thought to be an apocrine tumour, is now believed to be derived from anogenital mammary-like glands (MLG) and is more accurately termed MLG adenoma.
  • Tubular, papillary, cystic and solid areas were seen in various combinations.
  • Unusual architectural patterns resembled breast lesions such as erosive adenomatosis, sclerosing adenosis and ductal adenoma.
  • CONCLUSIONS: MLG adenomas demonstrate a marked diversity in histological pattern and cell morphology.
  • Unusual vulvar tumours, which have been previously reported as erosive adenomatosis, sclerosing adenosis, papillary adenofibroma, syringocystadenoma papilliferans, etc., are variants of MLG adenomas.
  • [MeSH-major] Adenoma / pathology. Mammary Glands, Human / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19404851.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 46
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