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1. Kuhn MT, Maclennan GT: Benign neoplasms of the epididymis. J Urol; 2005 Aug;174(2):723
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  • [Title] Benign neoplasms of the epididymis.
  • [MeSH-major] Adenoma / pathology. Cystadenoma, Papillary / pathology. Epididymis. Testicular Neoplasms / pathology

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  • (PMID = 16006963.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Ip YT, Dias Filho MA, Chan JK: Nuclear inclusions and pseudoinclusions: friends or foes of the surgical pathologist? Int J Surg Pathol; 2010 Dec;18(6):465-81
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  • Although not totally specific, they are particularly common in papillary thyroid carcinoma, meningioma, and usual ductal hyperplasia of the breast and hence may aid in the diagnosis of these entities.
  • Nuclear pseudo-pseudoinclusions, which are artefactual bubbles in the nuclei that mimic nuclear pseudoinclusions or clear nuclei, can lead to misdiagnosis of follicular adenoma or hyperplastic nodule as papillary thyroid carcinoma.

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  • (PMID = 21081532.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. de Matos PS, Ferreira AP, de Oliveira Facuri F, Assumpção LV, Metze K, Ward LS: Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy. Histopathology; 2005 Oct;47(4):391-401
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  • METHODS AND RESULTS: We evaluated 170 thyroid lesions including 148 neoplastic lesions [84 papillary carcinomas (PC), 38 follicular carcinomas (FC), 18 follicular adenomas, one hyalinizing trabecular tumour, five medullary carcinomas, two anaplastic carcinomas] and 22 non-neoplastic lesions (12 adenomatous nodules and 10 Hashimoto's thyroiditis).
  • Although the most helpful marker in terms of sensitivity and specificity for the follicular variant of PC and for FC diagnosis was HBME-1, when we consider the differentiation between cases of follicular variant of papillary carcinoma (FVPC) and FC or adenoma, in terms of percentage of positive cells, galectin-3 and CK 19 were more relevant.

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  • (PMID = 16178894.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / HBME-1 antigen; 68238-35-7 / Keratins
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4. Farnell MB: Surgical management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. J Gastrointest Surg; 2008 Mar;12(3):414-6
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  • [Title] Surgical management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
  • Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is characterized by papillary growths within the pancreatic ductal system that are at risk for undergoing malignant transformation.
  • [MeSH-major] Adenoma / surgery. Carcinoma in Situ / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery. Precancerous Conditions / surgery
  • [MeSH-minor] Carcinoma, Papillary / surgery. Diagnostic Imaging. Dilatation, Pathologic. Humans. Pancreatic Ducts / pathology. Pancreaticoduodenectomy

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  • (PMID = 17968632.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 24
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5. Pagedar NA, Chen DH, Wasman JK, Savvides P, Schluchter MD, Wilhelm SM, Lavertu P: Molecular classification of thyroid nodules by cytology. Laryngoscope; 2008 Apr;118(4):692-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent studies have characterized differences in gene expression between benign and malignant conditions, most often using whole tissue.
  • Preliminary analysis using fluorometry and reverse-transcriptase (RT)-PCR was performed.
  • RT-PCR revealed satisfactory RNA recovery in all other specimens. qPCR showed significant over-expression of fibronectin in the papillary carcinomas compared with the goiters (P = .0013), follicular adenomas (P = .0014), and follicular carcinomas (P = .0001).
  • Differences in both fibronectin and MUC1 expression between the follicular carcinomas and the follicular adenomas were also significant (P = .025 and .045, respectively).
  • Both fibronectin and MUC1 were differentially expressed in follicular adenomas and follicular carcinomas, and fibronectin expression differed in papillary carcinomas compared with the other lesions.
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Antigens, CD3 / analysis. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Carcinoma, Papillary / pathology. Cell Adhesion Molecules / analysis. Feasibility Studies. Fibronectins / analysis. Galectin 3 / analysis. Gene Expression Regulation, Neoplastic / genetics. Goiter / pathology. Humans. Molecular Biology. Mucin-1 / analysis. Polymerase Chain Reaction. Prospective Studies. Protein-Tyrosine Kinases / analysis. Proto-Oncogene Proteins / analysis. Proto-Oncogene Proteins c-met. Receptors, Growth Factor / analysis. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Neoplasms / pathology

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  • (PMID = 18094649.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / Fibronectins; 0 / Galectin 3; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Proto-Oncogene Proteins; 0 / Receptors, Growth Factor; 0 / tumor-associated antigen GA733; EC 2.7.10.1 / MET protein, human; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
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6. Yamada Y, Fujimura T, Takahashi S, Takeuchi T, Takazawa Y, Kitamura T: Tubulovillous adenoma developing after urinary reconstruction using ileal segments. Int J Urol; 2006 Aug;13(8):1134-5
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  • [Title] Tubulovillous adenoma developing after urinary reconstruction using ileal segments.
  • A case of tubulovillous adenoma arising in an augmented bladder is described.
  • Cystoscopy revealed a non-papillary multiple tumor at the site of ileovesical anastomosis and transurethral resection biopsy was performed.
  • Histopathological examination revealed a tubulovillous adenoma.
  • A tubulovillous adenoma developing at the augmented bladder is rare.
  • To our knowledge, this is the second case in which a tubulovillous adenoma developed in an augmented bladder.
  • [MeSH-major] Adenoma, Villous / etiology. Urinary Bladder / surgery. Urinary Bladder Neoplasms / etiology. Urinary Reservoirs, Continent

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  • (PMID = 16903947.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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7. Clerici T, Kolb W, Beutner U, Bareck E, Dotzenrath C, Kull C, Niederle B, German Association of Endocrine Surgeons: Diagnosis and treatment of small follicular thyroid carcinomas. Br J Surg; 2010 Jun;97(6):839-44
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  • Most initial diagnoses had to be revised because of incorrect size assessment or incorrect diagnosis (benign adenoma, papillary thyroid carcinoma (PTC), follicular variant of PTC).

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  • (PMID = 20473996.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Investigator] Kaserer K; Perren A; Schmid KW; Köberle-Wührer R; Wenzl E; Asari R; Klinge U; Müller G; Kroell KP; Blankenburg C; Voss H; Cupisti K; Witte J; Knoefel WT; Simon D; Lienenlüke RH; Vorländer C; Wacha H; Schabram J; Lorenz K; Dralle H; Wojciechowski B; Kussmann J; Weber Y; Schürmann G; Goretzki PE; Ulitzer H; Eberle A; Mayer M; Stabenow R; Stegmaier C; Bühlmann R; Schlumpf R; Triponez F; Ess SM
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8. Caria P, Vanni R: Cytogenetic and molecular events in adenoma and well-differentiated thyroid follicular-cell neoplasia. Cancer Genet Cytogenet; 2010 Nov;203(1):21-9
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  • [Title] Cytogenetic and molecular events in adenoma and well-differentiated thyroid follicular-cell neoplasia.
  • These neoplasms are divided into two main categories, papillary thyroid carcinoma and follicular thyroid carcinoma.
  • Thyroid adenoma is the benign counterpart of follicular carcinoma.
  • No benign counterpart of papillary carcinoma has yet been identified.
  • These structural changes lead to the formation of fusion genes RET-PTC, TRK(-T), and BRAF-AKAP9, which originate as a result of intrachromosomal or interchromosomal rearrangements and are found in papillary thyroid carcinoma.
  • Radiation exposure and the particular architectural arrangement of chromatin regions in which the affected genes lie during interphase are thought to favor the formation of fusion genes in papillary thyroid carcinoma and possibly also in follicular thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenoma / genetics. Chromosome Aberrations. Thyroid Neoplasms / genetics

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20951315.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / PAX8-PPARgamma fusion protein, human; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, trkA; EC 2.7.10.1 / ret-PTC fusion oncoproteins, human
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9. Ruggieri M, Straniero A, Mascaro A, Genderini M, D'Armiento M, Gargiulo P, Fumarola A, Trimboli P: The minimally invasive open video-assisted approach in surgical thyroid diseases. BMC Surg; 2005;5:9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / surgery. Adult. Aged. Carcinoma, Papillary / surgery. Female. Goiter, Nodular / surgery. Humans. Middle Aged. Minimally Invasive Surgical Procedures. Postoperative Complications. Thyroid Neoplasms / surgery. Treatment Outcome

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  • (PMID = 15857503.001).
  • [ISSN] 1471-2482
  • [Journal-full-title] BMC surgery
  • [ISO-abbreviation] BMC Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1131909
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10. Letsas KP, Frangou-Lazaridis M, Skyrlas A, Tsatsoulis A, Malamou-Mitsi V: Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesions. Pathol Int; 2005 Nov;55(11):694-702
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcription factor-mediated proliferation and apoptosis in benign and malignant thyroid lesions.
  • Proliferation and apoptosis-related transcription factor immunoexpression patterns were concomitantly investigated in tissue sections of normal thyroid, goiters, follicular adenomas and well-differentiated papillary and follicular carcinomas using antibodies against prothymosin alpha, E2F-1, p53, Bcl2, and Bax proteins.
  • Prothymosin alpha and E2F-1 immunoexpression levels were found to be significantly elevated in well-differentiated carcinomas compared to adenomas, goiters and normal tissues (P < 0.05).
  • [MeSH-minor] Adenoma / pathology. Adenoma / physiopathology. Adolescent. Adult. Aged. Carcinoma, Papillary, Follicular / pathology. Carcinoma, Papillary, Follicular / physiopathology. DNA-Binding Proteins / analysis. DNA-Binding Proteins / immunology. DNA-Binding Proteins / physiology. E2F1 Transcription Factor / analysis. E2F1 Transcription Factor / immunology. E2F1 Transcription Factor / physiology. Female. Goiter / pathology. Goiter / physiopathology. Humans. Immunohistochemistry. Male. Middle Aged. Protein Precursors / analysis. Protein Precursors / immunology. Protein Precursors / physiology. Repressor Proteins / analysis. Repressor Proteins / immunology. Repressor Proteins / physiology. Thymosin / analogs & derivatives. Thymosin / analysis. Thymosin / immunology. Thymosin / physiology. Tumor Suppressor Protein p53 / analysis. Tumor Suppressor Protein p53 / immunology. Tumor Suppressor Protein p53 / physiology. Tumor Suppressor Proteins / analysis. Tumor Suppressor Proteins / immunology. Tumor Suppressor Proteins / physiology. bcl-2-Associated X Protein / analysis. bcl-2-Associated X Protein / immunology. bcl-2-Associated X Protein / physiology

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  • (PMID = 16271081.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / BCLAF1 protein, human; 0 / DNA-Binding Proteins; 0 / E2F1 Transcription Factor; 0 / Protein Precursors; 0 / Repressor Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / bcl-2-Associated X Protein; 0 / prothymosin alpha; 61512-21-8 / Thymosin
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11. Gesierich W, Diwersy C, Leinsinger G, Massmann J, Präuer H, Höfler H, Fend F, Emslander HP: [Papillary adenoma of type-II pneumocytes as a rare differential diagnosis of a solitary pulmonary nodule]. Pneumologie; 2007 Nov;61(11):697-9
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  • [Title] [Papillary adenoma of type-II pneumocytes as a rare differential diagnosis of a solitary pulmonary nodule].
  • [Transliterated title] Papilläres Adenom der Typ-II-Pneumozyten als seltene Differenzialdiagnose eines pulmonalen Rundherdes.
  • The case of a 66-year-old, asymptomatic patient with a papillary adenoma of type-II pneumocytes is reported.
  • Papillary adenoma of type-II pneumocytes is a rare tumor, whose origin is suspected in progenitor cells of the bronchioloalveolar epithelium with the potential to differentiate towards type-II pneumocytes and clara cells.
  • The tumor is regarded as benign, however, a malignant potential is not excluded by some authors.
  • [MeSH-major] Adenoma / diagnosis. Lung / pathology. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / etiology

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  • (PMID = 17886196.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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12. Luo H, Li J, Yang T, Wang J: [Expression and significance of VEGF-C and VEGF-D in differentiated thyroid carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Jun;23(12):531-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: A tissue microarray containing 71 specimens was constructed, including normal thyroid tissues, thyroid adenoma, papillary thyroid carcinoma with and without lymphatic metastasis, follicular thyroid carcinoma.
  • RESULT: The expression of VEGF-C,D were not observed in normal thyroid tissues and adenoma tissues.
  • The expression of VEGF-C,D in papillary thyroid carcinoma was significantly higher than those in follicular thyroid carcinoma (P < 0.05) and adeno ma tissues (P < 0.01).
  • The expression of VEGF-C,D in papillary thyroid carcinoma with lymphatic metastasis was significantly higher than those in papillary thyroid carcinoma without lymphatic metastasis (P < 0.05).
  • CONCLUSION: By inducing proliferation of lymphatic endothelia cell and development of lymphatic vessels, VEGF-C,D contributed to lymphatic metastasis of papillary thyroid carcinoma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Thyroid Neoplasms / pathology. Vascular Endothelial Growth Factor C / metabolism. Vascular Endothelial Growth Factor D / biosynthesis

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  • (PMID = 19771906.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / VEGFC protein, human; 0 / Vascular Endothelial Growth Factor C; 0 / Vascular Endothelial Growth Factor D
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13. He CN, He L, Cheng JQ, Chen SC, Zhao HF, Zhai JP, Zhang J: [Expression of Twist in papillary thyroid carcinomas and its roles in differential diagnosis]. Zhonghua Bing Li Xue Za Zhi; 2008 Jan;37(1):35-9
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  • [Title] [Expression of Twist in papillary thyroid carcinomas and its roles in differential diagnosis].
  • OBJECTIVE: To study Twist expression in thyroid papillary carcinoma (PTC) by immunohistochemistry and to assess its usefulness as marker in the differential diagnosis of PTC, follicular adenomas (FA) and benign papillary lesions (BPL).
  • [MeSH-major] Carcinoma, Papillary / metabolism. Carcinoma, Papillary, Follicular / metabolism. Nuclear Proteins / metabolism. Thyroid Neoplasms / metabolism. Twist Transcription Factor / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Papillary / pathology. Adenoma / diagnosis. Adenoma / metabolism. Biomarkers, Tumor / immunology. Diagnosis, Differential. Galectin 3 / genetics. Galectin 3 / metabolism. Immunohistochemistry. Keratin-19 / genetics. Keratins / genetics. Keratins / metabolism. Thyroid Nodule / pathology

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  • (PMID = 18509983.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Keratin-19; 0 / Nuclear Proteins; 0 / TWIST1 protein, human; 0 / Twist Transcription Factor; 68238-35-7 / Keratins
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14. Mazal PR, Stichenwirth M, Koller A, Blach S, Haitel A, Susani M: Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study. Mod Pathol; 2005 Apr;18(4):535-40
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  • Immunohistochemistry for aquaporin-1, aquaporin-2, PAX-2, CD10, and cytokeratin 7 was performed on 102 clear cell renal cell carcinomas, 44 papillary renal cell carcinomas (among them 34 type 1 and 10 type 2), 24 chromophobe renal cell carcinomas, three collecting duct carcinomas (carcinomas of the collecting ducts of Bellini), and 29 oncocytomas.
  • Aquaporin-1 expression was found in clear cell renal cell carcinomas and papillary renal cell carcinomas of both types (78 and 73%, respectively), but not in chromophobe renal cell carcinomas, collecting duct carcinomas, and oncocytomas.
  • PAX-2 and CD10 was found in the majority of clear cell renal cell carcinomas (88 and 85%, respectively) but only in few papillary renal cell carcinomas, chromophobe renal cell carcinomas and oncocytomas.
  • Cytokeratin 7 was rarely seen in clear cell renal cell carcinomas, type 2 papillary renal cell carcinomas, and oncocytomas, but was found in the majority of type 1 papillary renal cell carcinomas (97.1%) and chromophobe renal cell carcinomas (88%).
  • Aquaporin-1 and PAX-2 expression was found to correlate with nuclear grading for clear cell renal cell carcinomas but not for papillary renal cell carcinomas.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Aquaporin 1. Aquaporin 2. Aquaporins / biosynthesis. Blood Group Antigens. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. DNA-Binding Proteins / biosynthesis. Humans. Immunohistochemistry. Keratin-7. Keratins / biosynthesis. Kidney / chemistry. Kidney / pathology. Neoplasm Staging. Neprilysin / biosynthesis. PAX2 Transcription Factor. Tissue Array Analysis / methods. Transcription Factors / biosynthesis

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  • (PMID = 15502805.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AQP1 protein, human; 0 / AQP2 protein, human; 0 / Aquaporin 2; 0 / Aquaporins; 0 / Biomarkers, Tumor; 0 / Blood Group Antigens; 0 / DNA-Binding Proteins; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human; 0 / Transcription Factors; 146410-94-8 / Aquaporin 1; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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15. Jarząb M, Lange D: Endogenous avidin biotin activity (EABA) in thyroid pathology: immunohistochemical study. Thyroid Res; 2009 Apr 08;2(1):5
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  • MATERIALS AND METHODS: The immunohistochemical study was performed on paraffin-embedded specimens of surgically resected thyroid tissue from 97 patients with thyroid diseases: 65 patients with papillary carcinoma (PTC), 11 patients with nodular goiter in whom features of benign papillary hyperplasia were found, 9 with lymphocytic thyroiditis (LT), 8 with follicular adenoma, and 4 patients with follicular carcinoma.
  • CONCLUSION: Among thyroid lesions, false positive reactions are highly probable in papillary thyroid carcinoma and in lymphocytic thyroiditis if immunohistochemical detection is used on systems containing (strept)avidin.

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  • (PMID = 19351422.001).
  • [ISSN] 1756-6614
  • [Journal-full-title] Thyroid research
  • [ISO-abbreviation] Thyroid Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2678080
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16. Young O, Crotty T, O'Connell R, O'Sullivan J, Curran AJ: Levels of oxidative damage and lipid peroxidation in thyroid neoplasia. Head Neck; 2010 Jun;32(6):750-6
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  • METHODS: Using tissue microarrays and immunohistochemistry, we assessed levels of DNA damage (8-oxo-dG) and lipid peroxidation (4-HNE) in 71 follicular thyroid adenoma (FTA), 45 papillary thyroid carcinoma (PTC), and 17 follicular thyroid carcinoma (FTC) and matched normal thyroid tissue.
  • CONCLUSION: High levels of DNA damage and lipid peroxidation in benign and malignant thyroid neoplasia indicates this damage is an early event that may influence disease progression.
  • [MeSH-major] Adenoma / physiopathology. DNA Damage. Lipid Peroxidation. Thyroid Neoplasms / physiopathology

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc. Head Neck, 2010.
  • (PMID = 19998441.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Antibodies, Monoclonal; 29343-52-0 / 4-hydroxy-2-nonenal; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; G9481N71RO / Deoxyguanosine
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17. Xue WC, Hui YZ: [Problems in the diagnosis of thyroid papillary and follicular carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2007 Apr;36(4):220-3
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  • [Title] [Problems in the diagnosis of thyroid papillary and follicular carcinoma].
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Carcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Carcinoma, Papillary, Follicular / diagnosis. Carcinoma, Papillary, Follicular / pathology. Cell Nucleus / pathology. Diagnosis, Differential. Humans. Neoplasm Invasiveness. Thyroid Gland / pathology. Thyroid Nodule / diagnosis. Thyroiditis / diagnosis

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  • (PMID = 17706110.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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18. Ito Y, Yoshida H, Tomoda C, Miya A, Kobayashi K, Matsuzuka F, Kakudo K, Kuma K, Miyauchi A: HBME-1 expression in follicular tumor of the thyroid: an investigation of whether it can be used as a marker to diagnose follicular carcinoma. Anticancer Res; 2005 Jan-Feb;25(1A):179-82
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  • In this study, we investigated whether it has a diagnostic value for discriminating follicular carcinoma from adenoma.
  • MATERIALS AND METHODS: We investigated HBME-1 expression in 138 follicular carcinomas, 155 follicular adenomas, 98 adenomatous nodules and 37 papillary carcinomas, using anti-HBME-1 monoclonal antibody.
  • RESULTS: HBME-1 was positive in 60.9% of follicular carcinoma and the incidence was significantly higher (p<0.0001) than that of follicular adenoma, 30.3%.
  • In adenomatous nodules, only 17.3% were classified as positive, which was lower even than that of follicular adenoma (p=0.0257).
  • All papillary carcinomas examined were positive for HBME-1.
  • We calculated the positive predictive value of HBME-1 in discriminating follicular carcinoma from adenoma as 64.2%.
  • CONCLUSION: These results suggest that, although HBME-1 contributes to the diagnosis of papillary carcinoma, it could not be applied in the preoperative diagnosis of follicular carcinoma, for example, using fine-needle aspiration biopsy samples.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. Biomarkers, Tumor / biosynthesis. Thyroid Neoplasms / metabolism

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  • (PMID = 15816536.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HBME-1 antigen
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19. Kim HG: [Biliary cystic neoplasm: biliary cystadenoma and biliary cystadenocarcinoma]. Korean J Gastroenterol; 2006 Jan;47(1):5-14
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  • Biliary cystadenomas are lined by single layer of cuboidal or columnar epithelium and are very often multilocular with septal or papillary foldings.
  • The epithelial lining of cystadenocarcinoma exhibits cellular atypia, mitotic activity, and infiltrative growth, but part of lining epithelium retain the feature of cystadenoma, which support the adenoma-carcinoma sequence.
  • Biliary cystic tumor should be considered when a single or multilocular cystic lesion with papillary infoldings is detected in the liver by computed tomogram (CT) or ultrasound (US).
  • US reveals a hypoechoic cystic mass with echogenic septation or papillary infoldings.

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  • (PMID = 16434863.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 64
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20. Lachinski AJ, Stefaniak T, Kobiela J, Connor S, Gruca Z, Sledzinski Z: New prognostic scales LAST-1 and LAST-2: supporting prediction and staging of thyroid cancer. World J Surg; 2006 Mar;30(3):309-20
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  • Although the results of surgical treatment of the highly differentiated (follicular and papillary) tumors seem to be satisfactory, treatment of the poorly differentiated (medullary and anaplastic) tumor still demands clinical and basic investigations.
  • The control groups consisted of 25 patients with multinodular goiter (MNG) and 32 patients with follicular adenoma (FA).
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Neoplasm Staging / methods. Thyroid Neoplasms / pathology

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  • (PMID = 16479347.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Ohno E, Hirooka Y, Itoh A, Ishigami M, Katano Y, Ohmiya N, Niwa Y, Goto H: Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasound findings of mural nodules. Ann Surg; 2009 Apr;249(4):628-34
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  • [Title] Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasound findings of mural nodules.
  • BACKGROUND AND AIM: Intraductal papillary mucinous neoplasms (IPMNs)have a wide pathologic spectrum and it is difficult to differentiate malignant from benign tumors.
  • Twelve clinicopathological variables and CE-EUS morphologic findings were assessed.Mural nodules defined as blood flow supplied protrusions were classified into 4 types: type I: low papillary nodule, type II: polypoid nodule, type III:papillary nodule, and type IV: invasive nodule.
  • RESULTS: Forty-two, 26, 16, and 3 were pathologically diagnosed as adenoma,noninvasive carcinoma, invasive IPMNs, and coexistent invasive ductal cancer, respectively.
  • CONCLUSIONS: In conclusion, new morphologic criteria were useful to identify the malignant potentials of IPMNs.

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  • (PMID = 19300203.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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22. Roberts SS, Mendonça-Torres MC, Jensen K, Francis GL, Vasko V: GABA receptor expression in benign and malignant thyroid tumors. Pathol Oncol Res; 2009 Dec;15(4):645-50
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  • [Title] GABA receptor expression in benign and malignant thyroid tumors.
  • We examined the expression patterns of the GABAergic system in 70 human thyroid tumor samples (13 follicular adenomas, 14 follicular carcinomas, 43 papillary carcinomas) and adjacent normal thyroid by immunohistochemistry.
  • Expression levels of GABAB R2 and GABA receptor associated protein (GABARAP) are increased in adenomas and thyroid cancer suggesting their role in early stages of thyroid tumorigenesis.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / metabolism. Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adenoma / metabolism. Adenoma / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Cell Line, Tumor. Humans. Microtubule-Associated Proteins / metabolism. Receptors, GABA-A / metabolism. Receptors, GABA-B / metabolism. Retrospective Studies

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  • (PMID = 19381877.001).
  • [ISSN] 1532-2807
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / GABARAP protein, human; 0 / Microtubule-Associated Proteins; 0 / Receptors, GABA; 0 / Receptors, GABA-A; 0 / Receptors, GABA-B
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23. Deiana L, Lai ML, Carta G, Mariotti S: Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma. Thyroid; 2008 Jul;18(7):813-4
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  • [Title] Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma.
  • [MeSH-major] Adenoma / pathology. Adenoma / ultrasonography. Carcinoma, Papillary / pathology. Carcinoma, Papillary / ultrasonography. Thyroid Neoplasms / ultrasonography. Thyroid Nodule / pathology. Thyroid Nodule / ultrasonography

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  • (PMID = 18631017.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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24. Zhu XL, Zhou XY, Zhu XZ: [BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma]. Zhonghua Bing Li Xue Za Zhi; 2005 May;34(5):270-4
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  • [Title] [BRAFV599E mutation and RET/PTC rearrangements in papillary thyroid carcinoma].
  • OBJECTIVE: To detect the BRAF(V599E) mutation and the RET/PTC chimeric gene in benign and malignant thyroid diseases and to explore their correlation with the clinicopathologic features of papillary thyroid carcinoma (PTC).
  • METHODS: PCR and RT-PCR were employed to detect BRAF(V599E) mutation and RET/PTC chimeric genes in 95 frozen and parraffine-embeded thyroid tissue. RESULTS:.
  • However, follicular types of PTC and other benign and malignant thyroid diseases were negative for BRAF(V599E) mutation. (2) Fourteen (21.2%) PTC cases expressed RET/PTC chimeric gene.
  • [MeSH-major] Carcinoma, Papillary / genetics. Oncogene Proteins, Fusion / genetics. Point Mutation. Protein-Tyrosine Kinases / genetics. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / pathology. Adenoma / genetics. Adenoma / pathology. Adolescent. Adult. Aged. Diagnosis, Differential. Female. Gene Rearrangement. Hashimoto Disease / genetics. Hashimoto Disease / pathology. Humans. Lymphatic Metastasis. Male. Middle Aged

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  • (PMID = 16181547.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / ret-PTC fusion oncoproteins, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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25. Lucas da Silva LB, Ribeiro DA, Cury PM, Cordeiro JA, Bueno V: FTY720 treatment in experimentally urethane-induced lung tumors. J Exp Ther Oncol; 2008;7(1):9-15
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  • Lung adenoma was induced in mice by urethane injection followed by different periods of FTY720 administration in order to evaluate lung tumor development.
  • G4 Group also presented the highest number of papillary nodules.
  • Therefore, our data suggest that FTY720 treatment in early periods after lung tumor induction is beneficial and impairs adenoma development.

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  • (PMID = 18472638.001).
  • [ISSN] 1359-4117
  • [Journal-full-title] Journal of experimental therapeutics & oncology
  • [ISO-abbreviation] J. Exp. Ther. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Carcinogens; 0 / Propylene Glycols; 3IN71E75Z5 / Urethane; G926EC510T / Fingolimod Hydrochloride; NGZ37HRE42 / Sphingosine
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26. Robertson A, Mansberg R, Mansberg V, Van der Wall H, Hooper M: Tumor-induced osteomalacia: a case of diagnostic dilemma. Clin Nucl Med; 2007 Aug;32(8):631-4
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  • Tumor-induced osteomalacia is typically caused by benign mesenchymal tumors of vascular or skeletal origin.
  • Histopathology showed a papillary carcinoma of the thyroid, a parathyroid adenoma, and an adrenal adenoma.

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  • (PMID = 17667438.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; RWM8CCW8GP / Octreotide
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27. Li G, Gentil-Perret A, Lambert C, Genin C, Tostain J: S100A1 and KIT gene expressions in common subtypes of renal tumours. Eur J Surg Oncol; 2005 Apr;31(3):299-303
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  • METHODS: Fifty-five tissue samples (15 clear cell RCCs, 15 papillary RCCs, 7 chromophobe RCCs, 8 oncocytomas and 10 normal renal tissues) were studied The gene expressions of S100A1 and KIT were analysed by one-step RT-PCR by using the specific primers.
  • RESULTS: S100A1 was expressed in 2/15 clear cell RCCs, 11/15 papillary RCCs, 7/8 oncocytomas and in 0/7 chromophobe RCCs.
  • KIT gene was expressed in 6/7 chromophobe RCCs and 7/8 oncocytomas while 0/15 clear cell RCCs and 1/15 papillary RCCs expressed kit gene.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / chemistry. Adenoma, Oxyphilic / chemistry. Carcinoma, Papillary / chemistry. Carcinoma, Renal Cell / chemistry. Cell Line, Tumor. Humans. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15780567.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 146909-89-9 / S100A11 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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28. Lin SD, Tu ST, Hsu SR, Chang JH, Yang KT, Yang LH: Synchronous parathyroid and papillary thyroid carcinoma. J Chin Med Assoc; 2005 Feb;68(2):87-91
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  • [Title] Synchronous parathyroid and papillary thyroid carcinoma.
  • The resected specimens were pathologically identified as papillary thyroid carcinoma and parathyroid carcinoma, respectively.
  • Although parathyroid carcinoma is an uncommon cause of parathyroid hormone-dependent hypercalcemia, it should nonetheless be given due consideration because its surgical approach differs from that of parathyroid adenoma.
  • [MeSH-major] Carcinoma, Papillary / complications. Neoplasms, Multiple Primary / complications. Parathyroid Neoplasms / complications. Thyroid Neoplasms / complications

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  • (PMID = 15759821.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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29. Zangana AM: Twisted mixed germ cell tumor of the ovary in a child. Saudi Med J; 2006 Aug;27(8):1240-3
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  • Four histological types of tumor tissues were found: well-differentiated adenocarcinoma, dysgerminoma, immature teratoma, and focus of papillary serous cyst adenoma as well.

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  • (PMID = 16883461.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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30. Blandamura S, Giacomelli L, Leo G, Segato P, Ninfo V: Nuclear maspin detection in renal cell tumours: possible diagnostic role and correlation with p53 status. Histopathology; 2006 Sep;49(3):274-82
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  • All clear cell carcinomas (CC) were negative for maspin, whereas oncocytomas (OC), papillary renal cell carcinomas (PC), chromophobe carcinomas (CPC) and, at least focally, collecting duct carcinomas (CDC) stained positively.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Serpins / biosynthesis

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  • (PMID = 16918974.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / SERPIN-B5; 0 / Serpins; 0 / Tumor Suppressor Protein p53
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31. Mitselou A, Ioachim E, Peschos D, Charalabopoulos K, Michael M, Agnantis NJ, Vougiouklakis T: E-cadherin adhesion molecule and syndecan-1 expression in various thyroid pathologies. Exp Oncol; 2007 Mar;29(1):54-60
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  • METHODS: A total of 55 TG carcinomas, 40 TG adenomas, 40 cases of hyperplastic TG disorders and 20 cases of normal TG autopsy samples, were evaluated by immunohistochemistry.
  • No significant change was seen in either molecule in hyperplastic TG disorders compared with TG adenomas.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Cadherins / metabolism. Carcinoma, Papillary / metabolism. Syndecan-1 / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Cell Differentiation. Humans. Middle Aged. Thyroid Gland / metabolism

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  • (PMID = 17431390.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / SDC1 protein, human; 0 / Syndecan-1
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32. Prasad ML, Pellegata NS, Huang Y, Nagaraja HN, de la Chapelle A, Kloos RT: Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Mod Pathol; 2005 Jan;18(1):48-57
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  • We evaluated the diagnostic use of the protein expression of four genes that were found to be upregulated in papillary thyroid carcinoma compared to normal thyroid (LGALS3, FN1, CITED1 and KRT19), and of the mesothelial cell surface protein recognized by monoclonal antibody HBME1 in thyroid tumors.
  • Tissues from 85 carcinomas (67 papillary, six follicular, eight Hürthle cell and four anaplastic) and 21 adenomas were evaluated by immunohistochemistry for the expression of these gene protein products, for example, galectin-3 (GAL3), fibronectin-1 (FN1), CITED1, cytokeratin-19 (CK19) and HBME1.
  • The expression of all five proteins was significantly associated with malignancy, and highly specific (> or = 90%) for carcinoma compared to adenoma.
  • GAL3, FN1 and/or HBME1 expression was seen in 100% of carcinomas (85/85) and in 24% of adenomas (5/21).
  • Coexpression of multiple proteins was seen in 95% of carcinomas and only 5% of adenomas (P<0.0001).
  • Coexpression of FN1 and GAL3 (FN1+ GAL3+, 70/85) or FN1 and HBME1 (FN1+ HBME1+, 53/85) was restricted to carcinomas, while their concurrent absence (FN1- GAL3- or FN1- HBME1-, 18/21 adenoma) was highly specific (96%) for benign lesions.
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Diagnosis, Differential. Fibronectins / analysis. Galectin 3 / analysis. Humans. Immunohistochemistry. Keratins / analysis. Nuclear Proteins. Statistics as Topic. Trans-Activators / analysis. Transcription Factors

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  • (PMID = 15272279.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01-RR00034
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CITED1 protein, human; 0 / Fibronectins; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Nuclear Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 68238-35-7 / Keratins
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33. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A: Diagnostic and prognostic value of angiogenesis-modulating genes in malignant thyroid neoplasms. Surgery; 2005 Dec;138(6):1102-9; discussion 1109-10
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  • We postulated that expression analysis of genes that modulate angiogenesis would identify differentially expressed genes that would help to distinguish benign from malignant thyroid neoplasms and serve as markers of aggressive differentiated thyroid cancer.
  • METHODS: A complementary DNA (cDNA) array with 96 genes that modulate angiogenesis was used to identify differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms.
  • Real-time quantitative polymerase chain reaction was used to confirm cDNA array expression data in 123 patients (4 normal thyroid, 26 hyperplastic nodules, 27 follicular adenomas, 23 follicular cancers, 18 follicular variant of papillary cancers, 25 papillary cancers).
  • RESULTS: Twenty-two genes were upregulated in malignant thyroid neoplasms by cDNA array analysis, but only 13 genes had higher messenger RNA (mRNA) expression levels in malignant than in benign thyroid neoplasms by real-time quantitative polymerase chain reaction (P < or = .04).
  • Of the 13 differentially expressed genes, the combined use of angiopoietin 2 (ANGPT2) and tissue inhibitor of metalloproteinase 1 (TIMP1) mRNA expression levels was best for distinguishing malignant from benign thyroid neoplasms, with a sensitivity of 90%, specificity of 85%, positive predictive value of 75%, and negative predictive value of 94%.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenoma / genetics. Angiogenic Proteins / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary, Follicular / genetics. Thyroid Neoplasms / genetics. Thyroid Nodule / genetics


34. Nishikawa N, Kimura Y, Okita K, Zembutsu H, Furuhata T, Katsuramaki T, Kimura S, Asanuma H, Hirata K: Intraductal papillary mucinous neoplasms of the pancreas: an analysis of protein expression and clinical features. J Hepatobiliary Pancreat Surg; 2006;13(4):327-35
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  • [Title] Intraductal papillary mucinous neoplasms of the pancreas: an analysis of protein expression and clinical features.
  • BACKGROUND/PURPOSE: The molecular pathology of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas has not been well characterized, and there are no reliable markers to predict the presence of associated invasive carcinoma in patients with IPMNs.
  • METHODS: Between May 1992 and September 2003, 37 patients with IPMNs, 24 with adenoma and 13 with carcinoma, underwent pancreatic resections at Sapporo Medical University Hospital, Japan.
  • Positive expression of MMP-7 was found in all of nine patients with infiltrating ductal pancreatic adenocarcinoma (IDC) and in all of seven patients with invasive intraductal papillary mucinous adenocarcinoma (IC-IPMC); however, 33.3% of patients with noninvasive IPMA, 58.3% of patients with intraductal papillary mucinous adenoma (IPMA), and all normal pancreatic tissues were negative for MMP-7; differences which were statistically significant (P < 0.05).
  • [MeSH-minor] Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / metabolism. Adenocarcinoma, Papillary / surgery. Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis

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  • (PMID = 16858545.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cadherins; 0 / Proliferating Cell Nuclear Antigen; 0 / Tumor Suppressor Protein p53; 0 / Vascular Endothelial Growth Factor A; EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
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35. Schueller-Weidekamm C, Kaserer K, Schueller G, Scheuba C, Ringl H, Weber M, Czerny C, Herneth AM: Can quantitative diffusion-weighted MR imaging differentiate benign and malignant cold thyroid nodules? Initial results in 25 patients. AJNR Am J Neuroradiol; 2009 Feb;30(2):417-22
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  • [Title] Can quantitative diffusion-weighted MR imaging differentiate benign and malignant cold thyroid nodules? Initial results in 25 patients.
  • The differences in the mean apparent diffusion coefficient (ADC) values in benign and malignant nodules were tested by using a Mann-Whitney U test.
  • RESULTS: Histologically, there were 20 carcinomas with a minimum size of 8 mm and 5 adenomas.
  • The mean ADC values (in 10(-3) mm(2)/s) differed significantly among carcinoma, adenoma, and normal parenchyma (P < .05).
  • The ranges (95% confidence interval) of the ADC values for carcinoma (2.43-3.037), adenoma (1.626-2.233), and normal parenchyma (1.253-1.602) showed no overlap.
  • CONCLUSIONS: Quantitative DWI seems to be a feasible tool with which to differentiate thyroid carcinomas from adenomas; however, further studies are required including larger numbers of patients to confirm our results.
  • [MeSH-major] Adenoma / diagnosis. Diffusion Magnetic Resonance Imaging / methods. Neoplasms / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pilot Projects. Prospective Studies. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 18945798.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Validation Studies
  • [Publication-country] United States
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36. Sheu SY, Grabellus F, Schwertheim S, Worm K, Broecker-Preuss M, Schmid KW: Differential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours. Br J Cancer; 2010 Jan 19;102(2):376-82
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  • [Title] Differential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours.
  • BACKGROUND: Recent studies showed a significant upregulation of distinct microRNAs (miRNAs) in papillary thyroid carcinoma (PTC).
  • METHODS: We used total RNA of 113 formalin-fixed paraffin-embedded tissues of 50 PTCs ((10 conventional type (PTC-CT), 10 tall cell variants (PTC-TCVs), 30 follicular variants (PTC-FVs)), 10 follicular adenomas (FAs), 10 multinodular goitres (MNGs), 21 follicular thyroid carcinomas and 22 well-differentiated tumours of unknown malignant potential (WDT-UMP) to analyse the miRNA expression pattern of five selected miRNAs (146b, 181b, 21, 221 and 222) using RT-PCR TaqMan miRNA assay to explore the diagnostic utility of this method.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Papillary / genetics. MicroRNAs / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Adult. Aged. Female. Gene Expression Profiling. Goiter, Nodular / genetics. Goiter, Nodular / pathology. Humans. Male. Middle Aged. Thyroid Diseases / genetics. Thyroid Diseases / pathology. Up-Regulation

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  • (PMID = 20029416.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MicroRNAs
  • [Other-IDs] NLM/ PMC2816660
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37. Meer S, Altini M: CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology; 2007 Jul;51(1):26-32
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  • The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepidermoid carcinoma (n = 21), polymorphous low-grade adenocarcinoma (n = 21), carcinoma ex-pleomorphic adenoma (n = 11), acinic cell carcinoma (n = 17), epimyoepithelial carcinoma (n = 7), oncocytic carcinoma (n = 3), hyalinizing clear cell carcinoma (n = 1), papillary cystadenocarcinoma (n = 1), salivary duct carcinoma (n = 3), adenocarcinoma (not otherwise specified) (n = 4) and squamous carcinoma (n = 4).
  • CONCLUSIONS: Although the CK7/20 immunoprofile is not useful in distinguishing the various types of salivary gland neoplasms or between benign and malignant salivary gland tumours, it may facilitate differentiation of primary salivary gland neoplasia from metastatic tumours and squamous carcinoma, and the diagnosis of metastatic salivary gland tumours.
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Salivary Glands / metabolism. Salivary Glands / pathology

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  • (PMID = 17593078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Keratin-20; 0 / Keratin-7
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38. Hayashi T, Ishiwatari H, Ihara H, Kawano Y, Takada K, Miyanishi K, Kobune M, Takimoto R, Sonoda T, Takayama T, Kato J, Niitsu Y: Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms. J Gastroenterol; 2009;44(9):964-75
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  • [Title] Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms.
  • BACKGROUND: When considering surgery for branch duct-intraductal papillary mucinous neoplasms (BD-IPMNs) with suspected malignancy, it should be recognized that these lesions are frequently multifocal and are usually found in elderly patients with potential comorbidities that could affect the outcome of surgery.
  • Immunohistochemical staining for cyclooxygenase-1 and -2 was negative in hyperplasia, adenoma and carcinoma portions of resected pancreatic specimens but was clearly positive for glutathione-S-transferase pi (GST-pi), suggesting that GST-pi is a putative target molecule for sulindac.
  • [MeSH-minor] Adenocarcinoma, Papillary / drug therapy. Adenocarcinoma, Papillary / pathology. Aged. Aged, 80 and over. Anti-Ulcer Agents / therapeutic use. Carcinoma, Pancreatic Ductal / drug therapy. Carcinoma, Pancreatic Ductal / pathology. Cholangiopancreatography, Magnetic Resonance / methods. Drug Delivery Systems. Endosonography / methods. Female. Glutathione S-Transferase pi / drug effects. Glutathione S-Transferase pi / metabolism. Humans. Male. Middle Aged. Omeprazole / therapeutic use. Tomography, X-Ray Computed / methods


39. Agarwal S, Das P, Singh MK, Sharma A, Karak AK: Papillary cystadenocarcinomas of salivary glands with oncocytic epithelial lining: report of 2 cases. Int J Surg Pathol; 2008 Jul;16(3):341-4
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  • [Title] Papillary cystadenocarcinomas of salivary glands with oncocytic epithelial lining: report of 2 cases.
  • Papillary cystadenocarcinoma involving the salivary glands is rare, and there are only about 13 case reports and a single large series of 57 cases in the literature.
  • [MeSH-major] Cystadenocarcinoma, Papillary / secondary. Oxyphil Cells / ultrastructure. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic. Child. Humans. Lymph Nodes / pathology. Male. Middle Aged. Mitochondria / ultrastructure. Parotid Gland / pathology. Submandibular Gland / pathology

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  • (PMID = 18573791.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Lee SY, Goh BK, Tan YM, Chung YF, Cheow PC, Chow PK, Wong WK, Ooi LL: Spleen-preserving distal pancreatectomy. Singapore Med J; 2008 Nov;49(11):883-5
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  • The indications were as follows : mucinous cystadenoma (n = 7), serous cystadenoma (n = 6), insulinoma (n = 3), intraductal papillary mucinous tumour (n = 2), pseudocyst (n = 3), papillary cystic adenoma (n = 1), neuroendocrine neoplasm (n = 1), and metastatic carcinoma of the thyroid (n = 1).

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  • (PMID = 19037554.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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41. Shih CM, Wu SC, Lee CC, Pan CC: Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis. J Chin Med Assoc; 2007 Jan;70(1):33-5
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  • [Title] Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis.
  • Villous adenoma is most frequently found in the colon and rectum, seldom in the urinary tract and even more rarely in the ureter or pelvis.
  • Ureteroscopy revealed papillary tumor obstructing the upper third of the ureter and inducing hydroureteronephrosis with abundant mucoid content.
  • The ureteral tumor proved to be villous adenoma by pathologic examination.
  • It should be noted that ureteral villous adenoma may be related to previous enteric-type metaplastic mucosa or ureteritis glandularis, demonstrates profuse production of mucus, and may eventually undergo malignant transformation.
  • [MeSH-major] Adenoma, Villous / complications. Hydronephrosis / etiology. Ureteral Neoplasms / complications

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  • (PMID = 17276931.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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42. Ito Y, Uramoto H, Funa K, Yoshida H, Jikuzono T, Asahi S, Higashiyama T, Tomoda C, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A: Delta Np73 expression in thyroid neoplasms originating from follicular cells. Pathology; 2006 Jun;38(3):205-9
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  • RESULTS: Normal follicular cells did not express delta Np73, but 27.3% of follicular adenoma, 85.4% of follicular carcinoma, 99.2% of papillary carcinoma, and 95.7% of anaplastic carcinoma were positive for the transcript.
  • In papillary carcinoma, the level was inversely linked to tumour size, extrathyroid extension, and clinically apparent metastasis.
  • Furthermore, in anaplastic carcinoma, delta Np73 expression level was significantly lower than that in papillary carcinoma.
  • CONCLUSIONS: Our findings indicate that delta Np73 plays a role predominantly in the early phase of papillary carcinoma progression.
  • [MeSH-major] Adenocarcinoma, Follicular / metabolism. Adenoma / metabolism. DNA-Binding Proteins / metabolism. Nuclear Proteins / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 16753740.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins
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43. Lerma E, Mora J: Telomerase activity in "suspicious" thyroid cytology. Cancer; 2005 Dec 25;105(6):492-7
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  • The histopathologic diagnoses were nodular hyperplasia in 5 patients, follicular adenoma in 3 patients, papillary carcinoma in 11 patients, follicular carcinoma in 1 patient, medullary carcinoma in 2 patients, and lymphoma in 1 patient.
  • TA was detected in 6 of 18 histologically confirmed thyroid neoplasms (1 of 3 follicular adenomas, 3 of 11 papillary carcinomas, 0 of 1 follicular carcinoma, 1 of 2 medullary carcinomas, and 1 of 1 lymphoma), including 1 neoplasm with scanty atypical cells.
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / enzymology. Adenocarcinoma, Follicular / pathology. Biopsy, Fine-Needle. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / enzymology. Carcinoma, Medullary / pathology. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / enzymology. Carcinoma, Papillary / pathology. Humans

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  • (PMID = 16104043.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.7.49 / Telomerase
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44. Hong HS, Kim MJ: [Diagnosis of pancreatic intraductal papillary mucinous neoplasm]. Korean J Gastroenterol; 2008 Oct;52(4):207-13
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  • [Title] [Diagnosis of pancreatic intraductal papillary mucinous neoplasm].
  • Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a unique disease entity that is characterized by predominant intraductal growth of mucinous cells, copious mucin production, and subsequent cystic dilatation of pancreatic ducts.
  • IPMN shows a spectrum of histologic and imaging findings and possesses as the potential for malignant transformation arising from adenoma to invasive carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 19077521.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 35
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45. Wang SL, Li SH, Chen WT, Chai CY: Expression of D2-40 in adjunct diagnosis of papillary thyroid carcinoma. APMIS; 2007 Aug;115(8):906-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of D2-40 in adjunct diagnosis of papillary thyroid carcinoma.
  • The clinical pathologic criteria for nuclear features of papillary thyroid carcinoma are subjective and sometimes cannot distinguish carcinoma from adenomatous goiter and follicular neoplasms.
  • Using quantitative analysis of immunohistochemical staining with D2-40, a recently available monoclonal antibody used as a lymphatic endothelial marker, we examined 72 cases of papillary carcinoma.
  • Controls included 36 follicular adenomas, 36 follicular carcinomas, and 20 adenomatous goiters with papillary hyperplasia.
  • Cytoplasmic D2-40 immunoreactivity was present in 60 of 72 papillary carcinomas, 2 cases of follicular adenoma and 2 cases of follicular carcinoma, whereas no adenomatous goiter or normal thyroid glands contained positive epithelial cells.
  • Overexpression of D2-40 in papillary thyroid carcinomas thus has potential diagnostic utility in differentiating these tumors from their potential histologic mimics.
  • [MeSH-major] Antibodies, Monoclonal. Biomarkers, Tumor / analysis. Carcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 17696946.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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46. Augustin T, Vandermeer TJ: Intraductal papillary mucinous neoplasm: a clinicopathologic review. Surg Clin North Am; 2010 Apr;90(2):377-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papillary mucinous neoplasm: a clinicopathologic review.
  • Intraductal papillary mucinous neoplasm (IPMN) is an intraductal mucin-producing epithelial neoplasm that arises from the main pancreatic duct (MD-IPMN), secondary branch ducts (BD-IPMN), or both (mixed type; Mix-IPMN).
  • Neoplastic progression from benign adenoma to invasive adenocarcinoma has not been proven but is generally thought to occur.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology

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  • (PMID = 20362793.001).
  • [ISSN] 1558-3171
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 96
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47. Camargo RS, Maeda MY, di Loreto C, Shirata NK, Anselmo Garcia E, Filho AL: Is agNOR and DNA ploidy analysis useful for evaluating thyroid neoplasms? Anal Quant Cytol Histol; 2005 Jun;27(3):157-61
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  • The diagnoses were: papillary carcinoma (n = 40), follicular carcinoma (n = 31), Hürthle cell adenocarcinoma (n = 4), and undifferentiated carcinoma (n = 6).
  • RESULTS: DNA ploidy analysis showed all Hürthle cell adenocarcinomas, 21 (67%)follicular tumors, 23 (57%) papillary tumors and 4 (67%) undifferentiated carcinomas to be aneuploid.

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  • (PMID = 16121637.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / Nuclear Proteins; 0 / nucleolar organizer region associated proteins
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48. Nojima H, Shimizu H, Kimura F, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Takano S, Kuboki S, Kato M, Miyazaki M: [A resected case of non-invasive type of intraductal papillary mucinous carcinoma penetrating to the duodenum]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2376-8
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  • [Title] [A resected case of non-invasive type of intraductal papillary mucinous carcinoma penetrating to the duodenum].
  • Biopsied specimen from the papillary nodule in the pancreatic duct showed adenoma.

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  • (PMID = 21224578.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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49. Milas M, Barbosa GF, Mitchell J, Berber E, Siperstein A, Gupta M: Effectiveness of peripheral thyrotropin receptor mRNA in follow-up of differentiated thyroid cancer. Ann Surg Oncol; 2009 Feb;16(2):473-80
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  • From 2002 to 2007, TSHR mRNA was prospectively measured by quantitative reverse-transcription polymerase chain reaction (RT-PCR) from peripheral blood samples in 259 patients, and those followed > or =3 months since initial thyroidectomy were studied.
  • Thirty-four patients underwent 20 +/- 14 months median follow-up for papillary (n = 31, 91%), follicular (n = 2) or Hurthle cell (n = 1) TC.
  • [MeSH-minor] Adenocarcinoma, Follicular / blood. Adenocarcinoma, Follicular / secondary. Adenocarcinoma, Follicular / surgery. Adenoma, Oxyphilic / blood. Adenoma, Oxyphilic / secondary. Adenoma, Oxyphilic / surgery. Adult. Aged. Autoantibodies / blood. Biomarkers, Tumor / blood. Carcinoma, Papillary / blood. Carcinoma, Papillary / secondary. Carcinoma, Papillary / surgery. Cell Differentiation. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / blood. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Positron-Emission Tomography. Prospective Studies. Reverse Transcriptase Polymerase Chain Reaction. Thyroglobulin / blood. Thyroglobulin / genetics. Thyroglobulin / immunology. Thyroidectomy. Thyrotropin / pharmacology. Young Adult

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  • (PMID = 19015922.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Receptors, Thyrotropin; 9002-71-5 / Thyrotropin; 9010-34-8 / Thyroglobulin
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50. Yasuda M, Ogane N, Hayashi H, Kameda Y, Miyagi Y, Iida T, Mori Y, Tsukinoki K, Minematsu T, Osamura Y: Glucose transporter-1 expression in the thyroid gland: clinicopathological significance for papillary carcinoma. Oncol Rep; 2005 Dec;14(6):1499-504
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Glucose transporter-1 expression in the thyroid gland: clinicopathological significance for papillary carcinoma.
  • Glucose transporter-1 (GLUT-1) expression was immunohistochemically analysed in a total of 268 cases of thyroid gland disease, including 129 cases of papillary carcinoma (PC), 60 cases of follicular carcinoma (FC), 57 cases of follicular adenoma, and 22 cases of adenomatous goitre.
  • GLUT-1 expression was observed in 5% (3/60) of FC cases, but all follicular adenomas and adenomatous goitres were negative for GLUT-1 (PC vs. FC, p<0.0001).
  • Semi-quantitative analysis of glut-1 mRNA by RT-PCR showed a tendency toward higher expression in PCs compared to FCs, follicular adenomas and adenomatous goitres, and the mRNA expression in PCs with a membrane-like pattern was higher than those showing cytoplasm-predominance.
  • 1) GLUT-1 is immunohistochemically useful in distinguishing PC from FC and benign diseases;.
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adenoma / metabolism. Adenoma / pathology. Blotting, Western. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Papillary / secondary. Gene Expression. Humans. Immunohistochemistry. Lymphatic Metastasis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / pathology

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  • (PMID = 16273245.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / RNA, Messenger
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51. Suffat LP, Fronda G, Maglione V, Righi D, Doriguzzi A, Repici A, De Paolis P: Cholangioscopic management of intrahepatic papillomatosis unsuitable for surgical treatment. Ann Ital Chir; 2009 Jan-Feb;80(1):35-8
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  • INTRODUCTION: Biliary papillomatosis can arise in any tract of the biliary three and is characterized by multiple papillary proliferation of the epithelial cells.
  • After a percutaneous drainage and with palliative intent we performed an Argon plasma coagulation of the papillary lesions.
  • Biliary papillomatosis grow according to the sequence adenoma-carcinoma with malignant transformation and poor prognosis due to multifocality and high recurrence rate.
  • [MeSH-major] Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Carcinoma, Papillary / surgery. Cholangiopancreatography, Endoscopic Retrograde / methods. Papilloma / surgery

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  • (PMID = 19537121.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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52. Troncone G, Iaccarino A, Russo M, Palmieri EA, Volante M, Papotti M, Viglietto G, Palombini L: Accumulation of p27(kip1) is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma. J Clin Pathol; 2007 Apr;60(4):377-81
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  • However, the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma expresses more p27 than benign oxyphilic lesions do.
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adenoma / metabolism. Adenoma / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Cyclin D3. Humans. Immunoprecipitation. Neoplasm Proteins / metabolism

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  • (PMID = 16798934.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CCND3 protein, human; 0 / Cyclin D3; 0 / Cyclins; 0 / Neoplasm Proteins; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
  • [Other-IDs] NLM/ PMC2001124
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53. Sanada Y, Kunita S, Yoshida K: Comparison of histologic subtype and growth pattern in intraductal papillary-mucinous carcinoma of the pancreas. Oncol Rep; 2008 Jun;19(6):1435-43
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  • [Title] Comparison of histologic subtype and growth pattern in intraductal papillary-mucinous carcinoma of the pancreas.
  • The purpose of this study was to compare histologic subtype and growth pattern, including invasion and intraductal spread to branch ducts, in main duct-type intraductal papillary-mucinous carcinoma (IPMC) by histopathology and immunohistochemistry.
  • Three cases showed adenoma components in the main duct.
  • The other case showed gastric-type adenoma and intestinal-type carcinoma in situ (CIS) in the main duct, with minimal tubular invasion.
  • The two remaining cases showed no adenoma components in the main duct, but showed abrupt transition from normal epithelium to CIS (pancreatobiliary type or oncocytic type) and massive invasion diffusely positive for OPRT.
  • These results suggest that IPMC with adenoma components in the main duct undergoes intraductal spread to branch ducts and has low malignant potential.
  • The progression of one subtype to another is associated with intraductal spread of intraductal papillary-mucinous neoplasm (IPMN).
  • However, IPMC without adenoma components is associated with marked invasion.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Cell Transformation, Neoplastic / pathology. Intestinal Neoplasms / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18497948.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / Mucins; EC 2.4.2.10 / Orotate Phosphoribosyltransferase
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54. Crippa S, Salvia R, Warshaw AL, Domínguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Castillo CF: Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg; 2008 Apr;247(4):571-9
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  • OBJECTIVE: Mucinous cystic neoplasms (MCNs) of the pancreas have often been confused with intraductal papillary mucinous neoplasms.
  • One hundred eighteen patients (72%) had adenoma, 17 (10.5%) borderline tumors, 9 (5.5%) in situ carcinoma, and 19 (12%) invasive carcinoma.
  • Patients with invasive carcinoma are older, suggesting progression from adenoma to carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18362619.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K08 DK071329
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS517373; NLM/ PMC3806104
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55. Lo CY, Lam KY, Leung PP, Luk JM: High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. Eur J Endocrinol; 2005 Apr;152(4):545-50
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  • [Title] High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma.
  • BACKGROUND: Cyclooxygenase-2 (COX-2) seems to play a role in the development and carcinogenesis of papillary thyroid carcinoma.
  • MATERIALS AND METHODS: Immunohistochemical staining for COX-2 expression was performed for 30 papillary thyroid carcinoma (PTC) and 40 benign thyroid specimens.
  • COX-2 mRNA expression was analyzed using a reverse transcriptase-polymerase chain reaction (RT-PCR) for paired fresh frozen tissues removed from surgically resected PTC specimens.
  • RESULTS: COX-2 expression was detected by immunohistochemistry in 27 of 30 (90%) PTC but was absent in 40 benign thyroid specimens, including 27 nodular hyperplasia, 7 follicular adenoma and 6 lymphocytic thyroiditis.
  • RT-PCR analysis confirmed COX-2 mRNA over-expression in 14 of 20 (70%) paired specimens of PTC.
  • Real-time quantitative RT-PCR showed that the level of COX-2 mRNA expression was significantly higher in PTC than in both the adjacent non-cancerous tissues and the benign thyroid specimens.
  • CONCLUSION: COX-2 is frequently expressed in PTC but not in benign thyroid specimens.

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  • (PMID = 15817909.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / RNA, Messenger; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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56. Frankel WL: Update on pancreatic endocrine tumors. Arch Pathol Lab Med; 2006 Jul;130(7):963-6
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  • The morphologic spectrum of these tumors can be variable, and the differential diagnosis includes chronic pancreatitis with neuroendocrine hyperplasia, ductal adenocarcinoma, solid pseudopapillary tumor, acinar cell carcinoma, and pancreatoblastoma.
  • It is important to be aware that unusual morphologic variants of pancreatic endocrine tumors are common, and immunohistochemical stains can help avoid misdiagnosis.
  • [MeSH-major] Adenoma, Islet Cell / pathology. Carcinoma, Islet Cell / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Acinar Cell / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Humans. Islets of Langerhans / pathology. Neoplasms, Germ Cell and Embryonal / diagnosis. Pancreatitis, Chronic / diagnosis. Prognosis

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  • (PMID = 16831051.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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57. Teixeira CS, Bitar RA, Martinho HS, Santos AB, Kulcsar MA, Friguglietti CU, da Costa RB, Arisawa EA, Martin AA: Thyroid tissue analysis through Raman spectroscopy. Analyst; 2009 Nov;134(11):2361-70
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  • Through the discriminative linear analysis of the Raman spectra of the tissue, it was possible to establish (in percentages) the correct classification index among the groups: goitre adjacent tissue, goitre nodular region, follicular adenoma, follicular carcinoma and papillary carcinoma.
  • Between goitre (nodular region and adjacent tissue) versus papillary carcinoma, the index of correct classification was 64.9%, which was considered good.
  • A relevant result was obtained in the analysis of the benign tissues (goitre and follicular adenoma) versus malignant tissues (papillary and follicular carcinomas), for which the index was 72.5% and considered good.

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  • (PMID = 19838427.001).
  • [ISSN] 1364-5528
  • [Journal-full-title] The Analyst
  • [ISO-abbreviation] Analyst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 06LU7C9H1V / Triiodothyronine; Q51BO43MG4 / Thyroxine
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58. Petterino C, Ratto A, Podestà G, Drigo M, Pellegrino C: Immunohistochemical evaluation of STAT3-p-tyr705 expression in feline mammary gland tumours and correlation with histologic grade. Res Vet Sci; 2007 Apr;82(2):218-24
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  • The samples included 4 normal mammary non-lactating tissues, 9 hyperplastic tissues (5 fibroepithelial hyperplasia and 4 lobular epithelial hyperplasia), 2 benign tumours (1 complex adenoma, and 1 simple adenoma), and 30 carcinomas (18 simple tubular papillary, 6 simple tubular, 2 simple solid, 3 cribriform, and 1 adenosquamous carcinoma).

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  • (PMID = 16934302.001).
  • [ISSN] 0034-5288
  • [Journal-full-title] Research in veterinary science
  • [ISO-abbreviation] Res. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / STAT3 Transcription Factor; 42HK56048U / Tyrosine
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59. Miseikyte-Kaubriene E, Ulys A, Trakymas M: [The frequency of malignant disease in cytological group of suspected cancer (ultrasound-guided fine-needle aspiration biopsy of nonpalpable thyroid nodules)]. Medicina (Kaunas); 2008;44(3):189-94
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  • BACKGROUND: Fine-needle aspiration biopsy is the most important procedure for differentiating benign thyroid nodules from malignant ones.
  • Traditionally, findings of fine-needle aspiration biopsy are divided into four categories: nondiagnostic, benign lesions, suspected cancer, and malignant lesions.
  • In 59.8% of cases, cytological examination revealed benign lesions; in 11.8%, suspected cancer; and in 22.5%, malignant lesions.
  • However, fine-needle aspiration biopsy is not effective diagnostic method for differentiating benign thyroid nodules from malignant ones in follicular neoplasm group.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Carcinoma, Papillary / pathology. Carcinoma, Papillary, Follicular / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / pathology. Thyroid Neoplasms / ultrasonography. Thyroid Nodule / pathology

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  • (PMID = 18413985.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] lit
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
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60. Kalinichenko OV, Myshunina TM, Tron'ko MD: [Cathepsin-like activity in blood plasma of patients with papillary thyroid carcinoma]. Fiziol Zh; 2010;56(6):70-80
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  • [Title] [Cathepsin-like activity in blood plasma of patients with papillary thyroid carcinoma].
  • The peculiarities of the thyroid changes depending on clinical characteristics of disease and histological structure of tumor were fixed by the studies of cathepsin-like activity in blood plasma of patients with papillary thyroid carcinoma.
  • H-cathepsin-like activity had a tendence to more significant increase especially in patients with concomitant benign thyroid disease with increasing the tumor category.
  • B-cathepsin-like activity in blood plasma had especially significant increased under tumor T1 category that was connected with nodular goiter or adenoma in a case concominant carcinoma by other thyroid pathology.
  • The results of the studies do not provide a rationale to consider that the cathepsin-like activity in blood of patients with papillary thyroid carcinoma can be the valuable additional biochemical criterion for differential diagnosis, estimation of the severity, and other characteristics of the disease.
  • [MeSH-major] Carcinoma, Papillary / blood. Cathepsins / blood. Thyroid Neoplasms / blood

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  • (PMID = 21469320.001).
  • [Journal-full-title] Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994)
  • [ISO-abbreviation] Fiziol Zh
  • [Language] ukr
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Biomarkers; EC 3.4.- / Cathepsins
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61. Ge Y, Luna MA, Cowan DF, Truong LD, Ayala AG: Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature. Ann Diagn Pathol; 2009 Dec;13(6):384-9
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  • (1) fat infiltration limited to follicular adenomas (thyrolipoma);.
  • (2) fat diffusely infiltrating throughout the thyroid gland (thyrolipomatosis); or (3) fat infiltration involving both follicular adenoma and their surrounding thyroid tissue.
  • In addition, a papillary thyroid carcinoma was also identified in one case of thyrolipomatosis.

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  • (PMID = 19917474.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] Q51BO43MG4 / Thyroxine
  • [Number-of-references] 19
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62. Sobrinho-Simões M, Máximo V, Castro IV, Fonseca E, Soares P, Garcia-Rostan G, Oliveira MC: Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance. Int J Surg Pathol; 2005 Jan;13(1):29-35
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  • Oxyphilia is classified into primary or secondary and the so-called Hürthle cell carcinoma is divided into oncocytic (Hürthle cell) variants of papillary and follicular carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology

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  • (PMID = 15735852.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  • [Number-of-references] 19
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63. Bradly DP, Reddy V, Prinz RA, Gattuso P: Incidental papillary carcinoma in patients treated surgically for benign thyroid diseases. Surgery; 2009 Dec;146(6):1099-104
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  • [Title] Incidental papillary carcinoma in patients treated surgically for benign thyroid diseases.
  • BACKGROUND: The frequency of incidental papillary carcinoma (IPC) has been reported to be between 4.6 % and 10% in operatively treated benign thyroid diseases.
  • This study reviews the occurrence of IPC in thyroid glands removed for benign disease at our institution.
  • METHODS: Six hundred and seventy-eight patients underwent partial or total thyroidectomy for benign thyroid diseases.
  • The incidence of IPC was compared among patients with Hashimoto's thyroiditis, multinodular goiter, follicular adenoma, and Graves' disease.
  • RESULTS: Overall, 81 (12.0%) IPCs were recorded with decreasing order of frequency: Hashimoto's thyroiditis, follicular adenoma, goiter, and Graves' disease.
  • Contralateral IPC was detected in 6/15 (40%) patients with follicular adenoma.
  • CONCLUSION: The overall incidence of IPC in benign operatively resected thyroid disease was 12%.
  • IPC was encountered in the contralateral lobe in 40% of patients with follicular adenoma.
  • Total thyroidectomy may be considered an appropriate operative treatment in patients with Hashimoto's thyroiditis and follicular adenoma requiring operation owing to the high incidence and frequent contralateral involvement of IPC, respectively.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Thyroid Diseases / surgery. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Chicago / epidemiology. Female. Goiter, Nodular / complications. Goiter, Nodular / surgery. Graves Disease / complications. Graves Disease / surgery. Hashimoto Disease / complications. Hashimoto Disease / surgery. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Multiple Primary / surgery. Thyroidectomy. Young Adult

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  • (PMID = 19958937.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Mete O, Kilicaslan I, Gulluoglu MG, Uysal V: Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis. Virchows Arch; 2005 Dec;447(6):938-46
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  • Thirty-five ROs and 77 eosinophilic RCCs (27 chromophobe, 28 clear cell and 22 papillary RCCs) were included in this study.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Biomarkers, Tumor / analysis. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology

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  • (PMID = 16133362.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Biomarkers, Tumor; 0 / CD63 protein, human; 0 / Platelet Membrane Glycoproteins; 68238-35-7 / Keratins
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65. Xu MR, Chen Y, Zhou SR, Chi MM, Chen SL, Liu LY: [Expressions of RASSF1A, Galectin-3 and TPO mRNA in papillary thyroid carcinoma and their clinical significance]. Zhonghua Zhong Liu Za Zhi; 2009 May;31(5):356-60
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  • [Title] [Expressions of RASSF1A, Galectin-3 and TPO mRNA in papillary thyroid carcinoma and their clinical significance].
  • OBJECTIVE: To investigate the mRNA expressions of RASSF1A, Galectin-3 and TPO in papillary thyroid carcinoma and some other thyroid benign lesions, and evaluate their diagnostic significance.
  • METHODS: Reverse transcription polymerase chain reaction (RT-PCR) was used to detect the mRNA expression of RASSF1A, galectin-3 and TPO in the samples from 73 cases, including 23 cases with papillary thyroid cancer, 16 with nodular goiter, 29 with thyroid adenoma and 5 with Hashimoto's disease.
  • RESULTS: A statistically significant difference in the mRNA expression of RASSF1A, Galectin-3 and TPO was observed between papillary thyroid carcinoma and follicular benign lesions (P<0.05).
  • However, there was no significant difference among various kinds of benign lesions (P>0.05).
  • A negative correlation of the expression of RASSF1A and Galectin-3 mRNA was found between thyroid benign lesions and malignant ones (P = 0.000).
  • While the mRNA expression of RASSF1A and TPO was positively correlated between benign and malignant lesions (P = 0.028).
  • CONCLUSION: Loss of expression of RASSF1A and TPO mRNA but high expression of Galectin-3 mRNA in papillary thyroid carcinoma are common.
  • Therefore, the products of these three genes may be closely related to the development of thyroid papillary carcinoma, and may be used as useful markers in differential diagnosis of papillary thyroid carcinoma from the benign lesions.
  • [MeSH-major] Autoantigens / metabolism. Carcinoma, Papillary / metabolism. Galectin 3 / metabolism. Iodide Peroxidase / metabolism. Iron-Binding Proteins / metabolism. Thyroid Neoplasms / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 19799084.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Autoantigens; 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / Iron-Binding Proteins; 0 / RASSF1 protein, human; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins; EC 1.11.1.7 / TPO protein, human; EC 1.11.1.8 / Iodide Peroxidase
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66. Handra-Luca A, Fléjou JF, Rufat P, Corcos O, Belghiti J, Ruszniewski P, Degott C, Bedossa P, Couvelard A: Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma. Histopathology; 2006 Jun;48(7):813-21
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  • [Title] Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma.
  • AIMS: To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs).
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Pancreatic Ductal / pathology. Cystadenoma, Mucinous / pathology. Cystadenoma, Papillary / pathology. Pancreatic Neoplasms / pathology


67. Kauffman EC, Barocas DA, Chen YT, Yang XJ, Scherr DS, Tu JJ: Differential expression of KAI1 metastasis suppressor protein in renal cell tumor histological subtypes. J Urol; 2009 May;181(5):2305-11
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  • MATERIALS AND METHODS: Immunohistochemical staining for KAI1 protein was performed in 152 nephrectomy specimens, including 48 clear cell, 35 papillary and 31 chromophobe renal cell carcinoma samples, 28 oncocytomas and 10 tumor-free kidneys.
  • Of the tumor specimens KAI1 protein was absent in all papillary renal cell carcinoma specimens.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Extracellular Matrix Proteins / metabolism. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology. Nerve Tissue Proteins / metabolism

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  • (PMID = 19303095.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Extracellular Matrix Proteins; 0 / KAL1 protein, human; 0 / Nerve Tissue Proteins
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68. Widder S, Guggisberg K, Khalil M, Pasieka JL: A pathologic re-review of follicular thyroid neoplasms: the impact of changing the threshold for the diagnosis of the follicular variant of papillary thyroid carcinoma. Surgery; 2008 Jul;144(1):80-5
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  • [Title] A pathologic re-review of follicular thyroid neoplasms: the impact of changing the threshold for the diagnosis of the follicular variant of papillary thyroid carcinoma.
  • BACKGROUND: Histopathologic criterion for follicular variant of papillary thyroid cancer (FVPTC) has only recently been utilized universally.
  • METHODS: A ten-year clinical cohort included patients with a diagnosis of a follicular adenoma, follicular carcinoma (FC), or FVPTC.
  • Initially, 118 were benign, 56 were FVPTC, and 11 were FC.
  • Overall, 46 (25%) patients had a change in diagnosis on re-review; 35 were reclassified from a benign diagnosis to a re-reviewed malignant diagnosis, with 5 reclassified as minimally invasive FC, 4 as occult PTC, and 26 (74%) as FVPTC.
  • Eleven patients were reclassified to a benign diagnosis.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Papillary / pathology. Diagnostic Errors / ethics. Ethics, Clinical. Thyroid Neoplasms / pathology


69. Naoi Y, Miyoshi Y, Taguchi T, Kim SJ, Arai T, Maruyama N, Tamaki Y, Noguchi S: Connexin26 expression is associated with aggressive phenotype in human papillary and follicular thyroid cancers. Cancer Lett; 2008 Apr 18;262(2):248-56
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  • [Title] Connexin26 expression is associated with aggressive phenotype in human papillary and follicular thyroid cancers.
  • In the study presented here, we investigated Cx26 expression in human papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) and its relationship with various clinicopathological parameters.
  • Of 69 PTCs, 33 were positive for Cx26 (47.8%), as were five of 11 FTCs (45.5%), all follicular thyroid adenomas (n=22) and normal thyroid tissues (n=20) were negative for Cx26.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Papillary / genetics. Connexins / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 18191019.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Connexins; 127120-53-0 / connexin 26
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70. Ishida M, Egawa S, Aoki T, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Unno M, Moriya T, Horii A, Furukawa T: Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas. Pancreas; 2007 Nov;35(4):348-52
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  • [Title] Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas.
  • OBJECTIVES: Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas encompasses a spectrum of neoplasms with both morphological and immunohistochemical variations of mucin glycoproteins.
  • Characteristically, the gastric-type IPMNs were likely to be diagnosed as benign, to be confined to branch ducts, and to have fair prognoses.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / pathology. Adenoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18090241.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / MUC2 protein, human; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins
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71. Xu L, Zhong F, Guo FF, Zhao WJ, Sun XR, Wei XF: [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid]. Zhonghua Bing Li Xue Za Zhi; 2008 Apr;37(4):243-9
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  • [Title] [Expression of motilin and its precursor mRNA in normal parenchyma, benign and malignant tumors of human thyroid].
  • METHODS: RT-PCR, Southern blot and molecular cloning were used to detect motilin transcript expression in human thyroid and mucous membrane of small intestine.
  • Real-time PCR and immunohistochemical techniques were used to quantify motilin precursor mRNA and motilin peptide in thyroid tissue samples including adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter. RESULTS:.
  • (1) The expression of motilin and its precursor mRNA in normal human thyroid was primarily in the thyroid C cells. (2) RT-PCR and Southern blot showed that motilin mRNA expressed in human thyroid was identical to that expressed in duodenum with identical sequence deposited in NCBI Genbank of America. (3) Immunohistochemistry, Western blot research and real-time PCR studies showed that motilin and its precursor mRNA were expressed in normal and tumor tissues of human thyroid.
  • Thyroid tumors (acidophilic adenoma, medullary carcinoma, follicular carcinoma, papillary carcinoma and nodular goiter) showed intense and diffuse immunostaining for motilin peptide.
  • Moreover, the expression of motilin and its precursor mRNA in thyroid medullar carcinoma and acidophilic adenoma were significantly higher than those of normal thyroid tissue (P < 0.05).
  • The expression in thyroid follicular and papillary carcinomas were significantly lower than those of normal thyroid tissue (P < 0.05).
  • The expressions of both motilin and its precursor mRNA in thyroid medullary carcinoma and acidophilic adenoma are significantly increased.
  • In contrast, their expressions in thyroid follicular and papillary carcinomas are significantly decreased.
  • Motilin may be involved in the pathogenesis of medullary carcinoma and acidophilic adenoma of the thyroid.
  • [MeSH-minor] Adenocarcinoma, Follicular / genetics. Adult. Aged. Carcinoma, Medullary / genetics. Carcinoma, Papillary / genetics. Carcinoma, Papillary / metabolism. Female. Humans. Intestines / metabolism. Male. Middle Aged. Nervous System Neoplasms / metabolism. Thyroid Gland / metabolism

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  • (PMID = 18844033.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA Precursors; 0 / RNA, Messenger; 52906-92-0 / Motilin
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72. Nakagohri T, Kinoshita T, Konishi M, Takahashi S, Gotohda N: Surgical outcome of intraductal papillary mucinous neoplasms of the pancreas. Ann Surg Oncol; 2007 Nov;14(11):3174-80
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  • [Title] Surgical outcome of intraductal papillary mucinous neoplasms of the pancreas.
  • OBJECTIVE: An increasing number of intraductal papillary mucinous neoplasms of the pancreas have been reported in recent years.
  • The objective of this study is to clarify the clinicopathologic features of intraductal papillary mucinous neoplasm of the pancreas and evaluate prognostic factors influencing survival.
  • METHODS: Eighty-two patients with intraductal papillary mucinous neoplasm undergoing surgical resection at the National Cancer Center Hospital East between April 1994 and October 2006 were retrospectively analyzed.
  • RESULTS: There were 31 patients with adenoma and 51 patients with carcinoma.
  • The 5-year survival rate for patients with intraductal papillary mucinous adenoma, noninvasive carcinoma, minimally invasive carcinoma, and invasive carcinoma was 80%, 78%, 83%, and 24%, respectively.
  • Regardless of the margin status, no patient with adenoma developed recurrent disease.
  • CONCLUSIONS: Patients with intraductal papillary mucinous adenoma, noninvasive carcinoma, and minimally invasive carcinoma showed favorable survival.
  • In contrast, invasive intraductal papillary mucinous carcinoma was associated with poor survival regardless of the margin status.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Biopsy, Needle. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Assessment. Survival Rate. Treatment Outcome

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  • (PMID = 17694416.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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73. Bakshi N, Kunju LP, Giordano T, Shah RB: Expression of renal cell carcinoma antigen (RCC) in renal epithelial and nonrenal tumors: diagnostic Implications. Appl Immunohistochem Mol Morphol; 2007 Sep;15(3):310-5
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  • Out of 241 REN, 173 were positive for RCC (sensitivity 72%): clear cell 72%, papillary 95%, chromophobe 91%, unclassified 85%, oncocytoma 75%, sarcomatoid 20%, and metastatic RCC 40%.
  • The overall immunostaining intensity was consistently much higher in papillary and clear cell RCC than in other tumors.
  • RCC expression was seen equally among adrenal adenoma and carcinoma group.

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  • (PMID = 17721277.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; EC 2.7.11.22 / MOK protein, human; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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74. Tena-Suck ML, Salinas-Lara C, Sánchez-García A, Rembao-Bojórquez D, Ortiz-Plata A: Late development of intraventricular papillary pituitary carcinoma after irradiation of prolactinoma. Surg Neurol; 2006 Nov;66(5):527-33; discussion 533
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  • [Title] Late development of intraventricular papillary pituitary carcinoma after irradiation of prolactinoma.
  • BACKGROUND: Intracranial dissemination of pituitary adenomas is a rare event that does not equate malignancy.
  • A case of papillary pituitary carcinoma developed 12 years after radiotherapy for prolactin-secreting hormone pituitary adenoma is presented.
  • CONCLUSIONS: The tumor was considered a primary pituitary papillary carcinoma.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Cerebral Ventricle Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Pituitary Neoplasms / diagnosis. Prolactinoma / diagnosis. Radiotherapy / adverse effects

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  • (PMID = 17084204.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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75. Mirshemirani A, Roshanzamir F, Tabari AK, Ghorobi J, Salehpoor S, Gorji FA: Thyroid nodules in childhood: a single institute experience. Iran J Pediatr; 2010 Mar;20(1):91-6
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  • 24 (75%) patients had benign and 8 (25%) malignant tumors.

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  • (PMID = 23056688.001).
  • [ISSN] 2008-2142
  • [Journal-full-title] Iranian journal of pediatrics
  • [ISO-abbreviation] Iran J Pediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3446001
  • [Keywords] NOTNLM ; Adenoma / Aspiration Biopsy / Carcinoma / Fine-Needle / Follicular / Papillary / Thyroid Nodule
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76. Wang LH, Zhao YJ, Wang XY, Yuan P, Xu WQ, Xiao JC, Xu JP, Luo BR: [Significance of galectin-3 and CD44v6 expression in differential diagnosis of thyroid nodules]. Zhonghua Zhong Liu Za Zhi; 2005 Sep;27(9):547-50
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  • OBJECTIVE: To investigate the difference of galectin-3 and CD44v6 expression between benign and malignant thyroid nodules, and to evaluate their clinical value in distinguishing thyroid cancer from benign thyroid nodules.
  • METHODS: The expression of galectin-3 and CD44v6 was immunohistochemically detected by the ABC method in 143 benign and malignant thyroid nodule samples.
  • RESULTS: Expression of these two markers in benign thyroid nodules: galectin-3 was negative in 10 cases of para-cancer normal tissue and 14 cases of benign nodules found in the other benign thyroid disease.
  • Also it was weakly positive in 2 of 22 follicular adenomas (9.1%).
  • But all three eosinophilic follicular adenomas were diffusely or focally positive for galectin-3.
  • CD44v6 was negative in 10 cases of para-cancer normal tissue, but positive in 4 of 14 nodular lesions found in benign thyroid diseases (28.6%).
  • It was also positive in 16 of 52 nodular goiters (30.8%), and weakly positive in 7 of 22 follicular adenomas (31.8%).
  • The positive rate of galectin-3 and CD44v6 expression in thyroid cancer was significantly higher than that in benign thyroid nodule and normal tissue (P < 0.001).
  • The sensitivity, specificity and accuracy of galectin-3 combined with CD44v6 in differentiating benign from malignant thyroid nodule were 80.8%, 93.4%, 88.8%; they were 96.2%, 90.1%, 92.3% for Galectin-3 alone.
  • CONCLUSION: The immunohistochemical expression of galectin-3 and CD44v6 by the ABC method is significantly higher in thyroid cancers than in benign thyroid nodules, especially galectin-3 in thyrocyte being helpful in differentiating benign thyroid nodule from thyroid cancer.
  • [MeSH-minor] Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / metabolism. Adenoma / diagnosis. Adenoma / metabolism. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male

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  • (PMID = 16438854.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / CD44v6 antigen; 0 / Galectin 3; 0 / Glycoproteins
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77. Koizumi M, Sata N, Yoshizawa K, Kurihara K, Yasuda Y: Carcinoma Arising from Brunner's Gland in the Duodenum after 17 Years of Observation - A Case Report and Literature Review. Case Rep Gastroenterol; 2007;1(1):103-9
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  • Esophagogastroduodenoscopy (EGD) detected a small protruding lesion in the duodenal bulb, which was diagnosed as Brunner's adenoma.
  • Histopathological assessment showed acidophilic cells with swollen nuclei, and clear cells forming a tubular or papillary tubule in the mucosal lamina propria and submucosal layer.

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  • (PMID = 21487554.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3073796
  • [Keywords] NOTNLM ; Adenocarcinoma / Brunner's gland / Duodenal cancer
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78. Liu YY, Morreau H, Kievit J, Romijn JA, Carrasco N, Smit JW: Combined immunostaining with galectin-3, fibronectin-1, CITED-1, Hector Battifora mesothelial-1, cytokeratin-19, peroxisome proliferator-activated receptor-{gamma}, and sodium/iodide symporter antibodies for the differential diagnosis of non-medullary thyroid carcinoma. Eur J Endocrinol; 2008 Mar;158(3):375-84
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  • OBJECTIVES: The microscopic distinction between benign and malignant thyroid lesions in clinical practice is still largely based on conventional histology.
  • METHODS: We used tissue arrays containing 177 thyroid tissues: 100 benign tissues (including normal thyroid, Graves disease, multinodular goiter, and follicular adenoma (FA)) and 77 thyroid carcinomas (including papillary thyroid carcinoma (PTC), follicular thyroid carcinoma, and follicular variant of PTC (FVPTC)).

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  • (PMID = 18299472.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers, Tumor; 0 / CITED1 protein, human; 0 / Fibronectins; 0 / Galectin 3; 0 / HBME-1 antigen; 0 / Keratin-19; 0 / Nuclear Proteins; 0 / PPAR gamma; 0 / Symporters; 0 / Transcription Factors; 0 / sodium-iodide symporter
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79. Mai KT, Teo I, Belanger EC, Robertson SJ, Marginean EC, Islam S: Progesterone receptor reactivity in renal oncocytoma and chromophobe renal cell carcinoma. Histopathology; 2008 Feb;52(3):277-82
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  • MATERIALS AND METHODS: Thirty-eight RO, 25 CHRCC, 20 papillary RCC with oncocytic cytoplasm and 10 clear cell RCC with dominant eosinophilic cytoplasm were submitted for immunohistochemistry for ER, PR, CD117 and RCC.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Receptors, Progesterone / metabolism


80. King DL, Stack BC Jr, Spring PM, Walker R, Bodenner DL: Incidence of thyroid carcinoma in fluorodeoxyglucose positron emission tomography-positive thyroid incidentalomas. Otolaryngol Head Neck Surg; 2007 Sep;137(3):400-4
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  • Papillary thyroid micro carcinomas were detected in four of the specimens that showed a benign pathology of the dominant nodule.
  • [MeSH-minor] Adenoma, Oxyphilic / epidemiology. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radionuclide imaging. Fluorodeoxyglucose F18. Humans. Incidence. Positron-Emission Tomography. Radiopharmaceuticals. Retrospective Studies. Whole Body Imaging

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  • (PMID = 17765765.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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81. Hemerly JP, Bastos AU, Cerutti JM: Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas. Eur J Endocrinol; 2010 Nov;163(5):747-55
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  • RESULTS: We identified four novel and two previously described non-synonymous variants in thyroid carcinomas, which were absent in benign tumours and paired normal thyroid.
  • Although IDH1 variants occurred at higher frequency in follicular thyroid carcinomas, follicular variant of papillary thyroid carcinoma (PTC) and undifferentiated thyroid carcinomas than the observed variants in classical PTC (15/72 vs 3/37), it was not significant (P=0.1).

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  • (PMID = 20702649.001).
  • [ISSN] 1479-683X
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42. / IDH1 protein, human
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82. Bukhari U, Sadiq S, Kehar SI: Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. J Pak Med Assoc; 2009 Jan;59(1):15-8
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  • [Title] Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma.
  • Formalin fixed paraffin embedded tissues of follicular adenoma, WDT-UMP and follicular variant of papillary carcinoma were obtained for CK 19 immunostaining.
  • RESULTS: All (16) cases of follicular adenoma were negative for CK19.
  • There were 43 cases of follicular variant of papillary carcinoma with 4+ CK 19 positivity, 14 were 3+ positive and 3 were 2+ positive.
  • CONCLUSION: CK19 is a good and useful diagnostic marker for differential diagnosis of follicular adenoma, WDT-UMP and follicular variant of papillary carcinoma.
  • [MeSH-major] Adenoma / physiopathology. Carcinoma, Papillary / physiopathology. Keratin-19

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  • (PMID = 19213370.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Keratin-19
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83. Okada K, Suzuki Y, Saito Y, Umemura S, Tokuda Y: Two cases of ductal adenoma of the breast. Breast Cancer; 2006;13(4):354-9
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  • [Title] Two cases of ductal adenoma of the breast.
  • We encountered two cases of ductal adenoma of the breast.
  • On excisional biopsy of the largest , intraoperative pathological examination of frozen sections was suspicious for ductal carcinoma with a differential diagnosis of intraductal papilloma or intraductal papillary carcinoma.
  • Ductal adenoma was diagnosed after pathological examination of the permanent sections.
  • Ductal adenoma (sclerosing papilloma) with hemorrhagic infarction was diagnosed.
  • It is noteworthy that ductal adenoma have clinical and histopathological features that should be differentiated from carcinoma, especially when the tumor is accompanied by secondary changes such as hemorrhage or infarction.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology

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  • (PMID = 17146162.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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84. Andreeva IuIu, Zavalishina LE, Frank GA: [Classification of urinary bladder tumors]. Arkh Patol; 2006 Sep-Oct;68(5):46-53
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  • It describes the features of the structure of different histological types of benign and malignant urothelial neoplasias in accordance with the 1999 and 2004 WHO classifications.
  • [MeSH-minor] Adenocarcinoma, Clear Cell / classification. Adenocarcinoma, Clear Cell / pathology. Adenoma, Villous / classification. Adenoma, Villous / pathology. Carcinoma, Papillary / classification. Carcinoma, Papillary / pathology. Carcinoma, Small Cell / classification. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / classification. Carcinoma, Transitional Cell / pathology. Humans. Urothelium / pathology. World Health Organization

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  • (PMID = 17144533.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Lectures
  • [Publication-country] Russia (Federation)
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85. Woo SM, Ryu JK, Lee SH, Yoon WJ, Kim YT, Yoon YB: Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients. Br J Surg; 2009 Apr;96(4):405-11
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  • [Title] Branch duct intraductal papillary mucinous neoplasms in a retrospective series of 190 patients.
  • BACKGROUND: A consensus conference has recommended close observation of branch duct intraductal papillary mucinous neoplasms (BD-IPMNs) smaller than 30 mm, without symptoms or mural nodules.
  • Eighteen patients had adenoma, 53 borderline malignancy, five carcinoma in situ and nine invasive carcinoma.


86. Dabelić N, Matesa N, Matesa-Anić D, Kusić Z: Malignancy risk assessment in adenomatoid nodules and suspicious follicular lesions of the thyroid obtained by fine needle aspiration cytology. Coll Antropol; 2010 Jun;34(2):349-54
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  • In FNA reports of adenomatoid nodule (N = 15), there were seven (47%) pathohistological diagnoses (PHDs) of nodular goiter, and eight (53%) PHDs of follicular adenoma.
  • In FNA reports of cellular follicular lesion (N = 73), there were 2 (3%) PHDs of thyroiditis, 32 (44%) PHDs of nodular goiter, 38 (52%) PHDs of follicular adenoma, and one (1%) PHD of papillary carcinoma.
  • In FNA reports of "suspicious for follicular neoplasm" (N = 76), there was one (1%) PHD of thyroiditis, 24 (32%) PHDs of nodular goiter, 47 (62%) PHDs of follicular adenoma and four (5%) diagnoses of papillary carcinoma.
  • In FNA reports of follicular neoplasm (N = 112), there were 25 (22%) PHDs of nodular goiter, 72 (64%) PHDs of follicular adenoma, and 15 (14%) PHDs of thyroid carcinoma.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adenoma / ultrasonography. Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Retrospective Studies. Risk Assessment

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  • (PMID = 20698101.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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87. Wang W, Zhou ZW, Wan DS, Lu ZH, Chen G, Pan ZZ, Li LR, Wu XJ, Ding PR: [Clinical analyses of 70 cases of multiple primary colorectal carcinoma]. Ai Zheng; 2008 May;27(5):505-9
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  • Thirty-three patients had colorectal carcinoma accompanying with adenoma and multiple polyps.
  • CONCLUSIONS: The occurrence of MPCC is largely related with adenomas and polyps.
  • The patients accompanying with adenoma and multiple polyps should be followed up intensively.
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Rectum / surgery. Retrospective Studies. Survival Rate

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  • (PMID = 18479600.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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88. Allory Y: [Practical approach to a kidney tumor with papillary architecture in the adult]. Ann Pathol; 2009 Nov;29 Spec No 1:S55-8
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  • [Title] [Practical approach to a kidney tumor with papillary architecture in the adult].
  • [Transliterated title] Conduite pratique devant une tumeur rénale de l'adulte d'architecture papillaire.
  • [MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology

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  • (PMID = 19887252.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Number-of-references] 9
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89. Carney JA, Hirokawa M, Lloyd RV, Papotti M, Sebo TJ: Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol; 2008 Dec;32(12):1877-89
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  • [Title] Hyalinizing trabecular tumors of the thyroid gland are almost all benign.
  • The neoplasms did not recur or metastasize during a follow-up period that averaged 10 years, and they were titled hyalinizing trabecular adenomas.
  • Later, discovery of RET/PTC mutations in the tumor resulted in it being designated as a type of papillary thyroid carcinoma.
  • We conclude that the overwhelming majority of hyalinizing trabecular tumors of the thyroid behave as benign neoplasms and that, at this time, hyalinizing trabecular adenoma is the most appropriate title for them.
  • [MeSH-major] Adenoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18813121.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Park BK: Comments on "Distribution of renal tumor growth rates determined by using serial volumetric CT measurements". Radiology; 2009 Jul;252(1):314; author reply 314-5
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  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / radiography. Adenoma, Oxyphilic / surgery. Adult. Aged. Aged, 80 and over. Angiomyolipoma / pathology. Angiomyolipoma / radiography. Angiomyolipoma / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / radiography. Carcinoma, Papillary / surgery. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / radiography. Carcinoma, Renal Cell / surgery. Disease Progression. Female. Humans. Male. Mathematical Computing. Middle Aged. Neoplasm Staging

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  • [CommentOn] Radiology. 2009 Jan;250(1):137-44 [19092093.001]
  • (PMID = 19561267.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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91. Fu Q, Yao GY, Tang XL, Chen LR, Zheng ZX: [Microsatellite instability and allele-specific chromosome 3p deletion in breast cancer and precancerous lesions]. Zhonghua Zhong Liu Za Zhi; 2007 Jan;29(1):34-40
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  • OBJECTIVE: To investigate the incidence and clinicopathologic significance of MSI and LOH on 3P in breast carcinoma and its precancerous lesions, intraductal papillary adenoma and ductal carcinoma in situ.
  • METHODS: 41 paired sporadic invasive breast carcinomas, 13 archival precancerous lesion specimens of the breast and 14 couples of benign hyperplasia were collected.
  • There was no MSI in benign hyperplasia.
  • [MeSH-minor] Acid Anhydride Hydrolases / metabolism. Adaptor Proteins, Signal Transducing / metabolism. Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Breast / metabolism. Breast / pathology. Carcinoma, Ductal, Breast / genetics. Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. DNA Mismatch Repair. Female. Humans. Hyperplasia. Immunohistochemistry. Loss of Heterozygosity. Lymphatic Metastasis. Middle Aged. Neoplasm Proteins / metabolism. Neoplasm Staging. Nuclear Proteins / metabolism. Polymerase Chain Reaction. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 17575691.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / MLH2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
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92. Dewil B, Van Damme B, Vander Poorten V, Delaere P, Debruyne F: Completion thyroidectomy after the unexpected diagnosis of thyroid cancer. B-ENT; 2005;1(2):67-72
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  • In our department, routine management includes completion thyroidectomy once the histopathological report concludes that there is carcinoma, except in cases of papillary carcinoma measuring less than 1 cm.
  • Because of the rather low re-operation rate, we prefer to perform a completion thyroidectomy to remove potential occult malignancy and to allow for postoperative 131I-treatment in all patients with a diagnosis of malignancy in their thyroid lobectomy specimen, with the exception of papillary carcinoma < 1 cm.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / surgery. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery. Thyroidectomy / methods
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / surgery. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Adolescent. Adult. Aged. Biopsy, Fine-Needle. Female. Humans. Male. Middle Aged. Neoplasm, Residual. Retrospective Studies. Thyroid Gland / pathology. Thyroid Gland / radionuclide imaging. Thyroid Gland / ultrasonography. Treatment Outcome

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  • (PMID = 16044737.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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93. Reichart PA, Kalz S, Rabel A, Bornstein MM: Carcinoma ex pleomorphic adenoma in a minor salivary gland: report of a case. Oral Maxillofac Surg; 2010 Mar;14(1):59-62
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  • [Title] Carcinoma ex pleomorphic adenoma in a minor salivary gland: report of a case.
  • BACKGROUND: Carcinoma ex pleomorphic adenoma is exceedingly rare in minor salivary glands of the oral cavity.
  • We present a case of carcinoma ex pleomorphic adenoma (CEPA) of the buccal mucosa in a 47-year-old Turkish patient.
  • Pleomorphic adenoma was the tentative diagnosis.
  • Histopathologic evaluation revealed a preexisting pleomorphic adenoma associated with adenoid tumor component with tubulo-cystic and papillary or pseudopapillary structures; CEPA was diagnosed.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 19816723.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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94. Ghossein R: Encapsulated malignant follicular cell-derived thyroid tumors. Endocr Pathol; 2010 Dec;21(4):212-8
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  • This group includes encapsulated follicular variant of papillary carcinoma (FVPTC) and encapsulated (so-called minimally invasive) follicular carcinoma (EFC).
  • Encapsulated FVPTC have a molecular profile very close to follicular adenomas/carcinomas (high rate of RAS and absence of BRAF mutations).
  • Infiltrative follicular variant has an opposite molecular profile closer to classical papillary thyroid carcinoma than to follicular adenoma/carcinoma (BRAF > RAS mutations).
  • Encapsulated FVPTC have a molecular profile and a clinical behavior very similar to the follicular adenoma/carcinoma class of tumor.
  • [MeSH-major] Carcinoma, Papillary, Follicular / classification. Carcinoma, Papillary, Follicular / pathology

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  • (PMID = 21088998.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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95. Brzeziańska E, Cyniak-Magierska A, Sporny S, Pastuszak-Lewandoska D, Lewiński A: Assessment of cyclin D1 gene expression as a prognostic factor in benign and malignant thyroid lesions. Neuro Endocrinol Lett; 2007 Aug;28(4):341-50
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  • [Title] Assessment of cyclin D1 gene expression as a prognostic factor in benign and malignant thyroid lesions.
  • 1) an assessment of CCND1 gene expression level in benign and malignant thyroid lesions and 2) the evaluation of possible correlations between gene expression and the histopathological variants of papillary thyroid carcinoma (PTC), or tumour size, classified according to TNM definition of primary tumours (in case of PTC only) or patient's sex or age.
  • DESIGN: Thirty five (35) tissue samples were analysed: 24 cases of PTC, 4 cases of medullary thyroid carcinoma (MTC), 4 cases of follicular adenoma (FA) and 3 cases of nodular goitre (NG).
  • In real-time polymerase chain reaction (real-time PCR), two-step RT-PCR (reverse transcriptase-polymerase chain reaction) in an ABI PRISM 7500 Sequence Detection System was employed.
  • [MeSH-major] Carcinoma, Medullary / metabolism. Carcinoma, Papillary / metabolism. Cyclins / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Biopsy. Cyclin D. Female. Gene Expression Regulation, Neoplastic. Goiter, Nodular / diagnosis. Goiter, Nodular / metabolism. Goiter, Nodular / pathology. Humans. Male. Middle Aged. Prognosis

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  • (PMID = 17693985.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin D; 0 / Cyclins
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96. Nguyen HD, Galitz MS, Mai VQ, Clyde PW, Glister BC, Shakir MK: Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. Thyroid; 2010 Jan;20(1):99-103
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  • [Title] Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge.
  • BACKGROUND: A thyrotropin (TSH)-secreting pituitary adenoma coexisting with differentiated thyroid carcinoma is rare.
  • METHODS: We hereby report the fifth case, in which a patient presented with a TSH/growth-hormone-secreting pituitary macroadenoma coexisting with papillary thyroid carcinoma (PTC).
  • She has remained asymptomatic for 24 months without biochemical or radiological evidence of pituitary hormone oversecretion, pituitary adenoma enlargement, and PTC recurrence.
  • [MeSH-major] Adenoma. Carcinoma, Papillary. Human Growth Hormone / biosynthesis. Neoplasms, Multiple Primary. Pituitary Neoplasms. Thyroid Neoplasms. Thyrotropin / biosynthesis

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  • (PMID = 20067380.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Delayed-Action Preparations; 0 / Iodine Radioisotopes; 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine; RWM8CCW8GP / Octreotide
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97. Moon JH, Cha SW, Cho YD, Ryu CB, Cheon YK, Kwon KW, Kim YS, Kim YS, Lee JS, Lee MS, Shim CS, Kim BS: Wire-guided endoscopic snare papillectomy for tumors of the major duodenal papilla. Gastrointest Endosc; 2005 Mar;61(3):461-6
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  • BACKGROUND: Endoscopic excision for adenoma of the major duodenal papilla was introduced as an alternative to surgery, but postprocedure pancreatitis is a serious drawback.
  • This appears to prevent pancreatitis and to improve the outcome for patients undergoing endoscopic resection of papillary tumors.

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  • (PMID = 15758926.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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98. Mazzoni A: The petro-occipital trans-sigmoid approach for lesions of the jugular foramen. Skull Base; 2009 Jan;19(1):48-56
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  • A retrospective review was conducted of 61 patients with jugular fossa tumors that included lower cranial nerve schwannomas, paragangliomas, meningiomas, chordomas, cholesteatomas, and other benign or low-grade malignant tumors.
  • Good outcomes were achieved for schwannomas, meningiomas, chondrosarcomas, and papillary adenoma.

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  • (PMID = 19568342.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2637570
  • [Keywords] NOTNLM ; Jugular foramen / petro-occipital trans-sigmoid approach / surgical procedures / tumors of jugular foramen
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99. Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, Iaccarino A, Russo M, Pierantoni GM, Leone V, Sacchetti S, Troncone G, Santoro M, Fusco A: Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Cancer Res; 2008 Aug 15;68(16):6770-8
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  • Indeed, it decreased in an increasing percentage of cases going from benign adenomas to papillary (PTC), follicular, and anaplastic (ATC) thyroid carcinomas.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Carcinoma / genetics. Carcinoma, Papillary / genetics. Repressor Proteins / genetics. Repressor Proteins / metabolism. Thyroid Neoplasms / genetics

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  • (PMID = 18701502.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CBX7 protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Repressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
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100. Mai KT, Kohler DM, Robertson SJ, Belanger EC, Marginean EC: Oncocytic papillary renal cell carcinoma with solid architecture: mimic of renal oncocytoma. Pathol Int; 2008 Mar;58(3):164-8
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  • [Title] Oncocytic papillary renal cell carcinoma with solid architecture: mimic of renal oncocytoma.
  • Papillary renal cell carcinoma (PRCC) can display extensive areas of solid and non-papillary architecture and extensive areas with oncocytic cytoplasm.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Papillary / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis






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