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1. Ohi Y, Umekita Y, Rai Y, Kukita T, Sagara Y, Sagara Y, Takahama T, Andou M, Sagara Y, Yoshida A, Yoshida H: Clear cell hidradenoma of the breast: a case report with review of the literature. Breast Cancer; 2007;14(3):307-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma of the breast: a case report with review of the literature.
  • Clear cell hidradenoma of the breast is rare.
  • Histological examination demonstrated characteristic histological features of clear cell hidradenoma, such as proliferation of uniform epithelial cells, clear or slightly eosinophilic cytoplasm, and cuboidal cell-lined ductal structures.
  • These features were consistent with clear cell hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Breast Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17690510.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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2. Cihocki LM, Divers TJ, Johnson AL, Warren AL, Schramme M, Rassnick KM, Scott DW: A case of multiple epitrichial sweat gland ductal carcinomas in a horse. Vet Dermatol; 2007 Apr;18(2):134-7
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  • [Title] A case of multiple epitrichial sweat gland ductal carcinomas in a horse.
  • This case report describes a rare epitrichial sweat gland ductal carcinoma in a 14-year-old horse and is the first report of multiple carcinomas of this type in horses.
  • [MeSH-major] Adenoma, Sweat Gland / veterinary. Horse Diseases / diagnosis. Neoplasms, Multiple Primary / veterinary. Sweat Gland Neoplasms / veterinary

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  • (PMID = 17355430.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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3. Missall TA, Burkemper NM, Jensen SL, Hurley MY: Immunohistochemical differentiation of four benign eccrine tumors. J Cutan Pathol; 2009 Feb;36(2):190-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical differentiation of four benign eccrine tumors.
  • BACKGROUND: The histogenesis and differentiation of eccrine tumors, including cylindroma, poroma, spiradenoma and syringoma, remains controversial.
  • METHODS: Ten examples each of normal eccrine structures and of four benign eccrine tumors are analyzed with antibodies to cytokeratin (CK) 7, CD34, CK6, CK10, smooth muscle actin (SMA) and CD10.
  • These markers represent two different immunohistochemical stains for each part of the eccrine structure; CK7 and CD34 stain the secretory coil, CK6 and CK10 stain the straight duct and SMA and CD10 stain the myoepithelial cells.
  • This redundancy in staining is performed on four benign eccrine tumors to better interpret the existing literature.
  • SMA appears to be a more specific marker for myoepithelial cells surrounding normal eccrine coils, and none of the studied tumors express SMA or CD10.
  • CONCLUSIONS: Our studies suggest that syringomas are tumors of the eccrine duct, while cylindromas and spiradenomas are tumors of the secretory coil.
  • [MeSH-major] Adenoma, Sweat Gland. Antigens, CD34 / biosynthesis. Biomarkers, Tumor / biosynthesis. Keratins / biosynthesis. Neprilysin / biosynthesis. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Humans. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 18564284.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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4. Premalata CS, Kumar RV, Malathi M, Shenoy AM, Nanjundappa N: Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. Int J Dermatol; 2007 Mar;46(3):306-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • X-Ray of the skull was normal and no evidence of metastatic disease was identified.
  • The specimen of the initial surgery consisted of skin-covered tissue with an exophytic firm growth measuring 6 x 5 x 4 cm.
  • The skin surface was rough with areas of ulceration.
  • The third lesion was a spindle cell sarcoma which formed the major part of the lesion, diffusely infiltrating the dermis and subcutaneous tissue, elevating and ulcerating the overlying skin.
  • The tumor cells were seen encircling the sweat glands, without destroying them (Fig. 3).
  • The wide excision specimen of the recurrent swelling consisted of a skin-covered nodule with ulceration, measuring 3 x 4 x 3 cm, with a gray-white whorled cut surface.
  • Multiple sections showed only spindle cell sarcoma infiltrating the skin and subcutaneous tissue, morphologically similar to the earlier tumor, with ulceration of the overlying skin.
  • The patient received postoperative radiotherapy and is disease free 8 months after diagnosis.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Leiomyosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Scalp. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


5. Simeonov RS, Simeonova GP: Use of quantitative analysis as a method for differentiation between canine cutaneous apocrine adenomas and apocrine carcinomas on cytological smears. J Vet Med A Physiol Pathol Clin Med; 2007 Nov;54(9):542-4
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  • [Title] Use of quantitative analysis as a method for differentiation between canine cutaneous apocrine adenomas and apocrine carcinomas on cytological smears.
  • Eight canine cutaneous adenomas and eight canine cutaneous carcinomas were analysed by computer-assisted nuclear morphometry in Hemacolor-stained cytological specimens.
  • The results indicated an increase in the mean values of investigated parameters from canine cutaneous apocrine adenomas (MNA, 75.65+/-2.22; MNP, 31.05+/-0.55; MND, 9.62+/-0.14; NR, 1.10+/-0.009) to canine cutaneous apocrine carcinomas (MNA, 88.78+/-11.29; MNP, 34.38+/-2.43; MND, 10.43+/-0.76; NR, 1.21+/-0.07).
  • The statistical analysis revealed statistically significant differences between benign and malignant neoplastic cells (P<0.01).
  • The results indicated that the computerized morphometry could be used as an effective auxiliary tool for differential diagnosis between canine cutaneous adenomas and carcinomas on cytological smears.
  • [MeSH-major] Adenoma / veterinary. Apocrine Glands / cytology. Carcinoma / veterinary. Cell Nucleus / pathology. Dog Diseases / pathology. Sweat Gland Neoplasms / veterinary

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  • (PMID = 17931233.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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6. El-Naggar AK: Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. Adv Anat Pathol; 2006 Mar;13(2):80-2
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  • [Title] Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics. Sweat Gland Neoplasms / genetics. Transcription Factors / genetics. Translocation, Genetic

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  • (PMID = 16670462.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Transcription Factors
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7. Hamsch C, Hartschuh W: Microcystic adnexal carcinoma - aggressive infiltrative tumor often with innocent clinical appearance. J Dtsch Dermatol Ges; 2010 Apr;8(4):275-8
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  • Microcystic adnexal carcinoma is a rare sweat gland malignancy, characterized by slow, but aggressive infiltrative growth.
  • The benign histologic appearance, particularly in the upper level of the tumor, can be confused with syringoma or benign follicular neoplasm.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Facial Neoplasms / pathology. Facial Neoplasms / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery
  • [MeSH-minor] Adenoma. Aged. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 19788582.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Uke MS, Kulkarni MB, Ajit D, Gujral S: Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):907-10
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  • [Title] Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report.
  • BACKGROUND: Hidradenoma papilliferum is a rare benign tumor of the vulva that occurs mainly in women in the skin of the anogenital region.
  • Repeat vulvar smears showed mainly groups and clusters of benign-looking glandular cells and were interpreted as a benign tumor.
  • Subsequent histology confirmed the diagnosis of hidradenoma papilliferum.
  • CONCLUSION: This case highlights the cytologic features of hidradenoma papilliferum on cytologic smears.
  • [MeSH-major] Acrospiroma / diagnosis. Cytological Techniques. Sweat Gland Neoplasms / diagnosis. Vulva / pathology

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  • (PMID = 21053567.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Al-Faky YH, Al-Mosallam AR, Al-Sohaibani MO: Periocular hidradenoma papilliferum. Saudi J Ophthalmol; 2009 Oct;23(3-4):211-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periocular hidradenoma papilliferum.
  • Hidradenoma is a benign adnexal neoplasm originating from the apocrine sweat gland, and is almost exclusively detectable in the skin of the anogenital area of middle-aged white females after puberty.
  • Ectopic hidradenoma papilliferum, which involves the skin away from the anogenital region, is exceedingly rare, and can also affect males.

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  • (PMID = 23960862.001).
  • [ISSN] 1319-4534
  • [Journal-full-title] Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
  • [ISO-abbreviation] Saudi J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3729807
  • [Keywords] NOTNLM ; Childhood / Ectopic / Hidradenoma papilliferum
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10. Ishida M, Kojima F, Kushima R, Kakutani A, Okabe H: [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin]. Rinsho Byori; 2006 Aug;54(8):781-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin].
  • Mucinous metaplasia rarely develops in the non-neoplastic skin or its appendages, and almost exclusively confined to the genitalia, palms and soles.
  • Here we report a new case of clear cell hidradenoma with mucinous metaplasia in the forehead.
  • Our immunohistochemical analysis revealed MUC5AC in the mucinous metaplastic cells of this tumor as in the extramammary Paget's disease, and expression of this gastric foveolar epithelial mucin core protein in these two neoplastic conditions seem to related to their common apocrine origin.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Forehead. Mucins / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 16989395.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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11. Gorva AD: Digital papillary adenoma (ADPA) and aggressive digital papillary adenocarcinoma (AdPACa). Am J Dermatopathol; 2005 Dec;27(6):546-7; author reply 547
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  • [Title] Digital papillary adenoma (ADPA) and aggressive digital papillary adenocarcinoma (AdPACa).
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Adenoma / pathology. Fingers / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentOn] Am J Dermatopathol. 2001 Apr;23(2):154-7 [11285414.001]
  • [ErratumIn] Am J Dermatopathol. 2006 Apr;28(2):180. Gorva, Anandkumar D [added]
  • (PMID = 16314709.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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12. Misago N, Narisawa Y: Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation. J Dermatol; 2006 Jan;33(1):2-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation.
  • To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation.
  • All eight cases of AMT of the skin showed CK15 immunostaining of the neoplastic cells, and all four cases of syringocystadenoma papilliferum, all five cases of spiradenoma, and both cases of cylindroma also showed a focally positive reaction to CK15.
  • None of the other benign neoplasms with presumed apocrine differentiation showed CK15 expression.
  • In AMT of the skin, the proportion of CK15-positive cells in the follicular or sebaceous differentiation group (78.8%, average of four cases) was significantly higher than the group without this differentiation (8.8%, average of four cases).
  • AMT of the skin are unique among benign neoplasms with apocrine differentiation in their substantial and constant CK15 expression, suggesting that they derive from multipotent epithelial stem cells in the bulge.
  • AMT of the skin with follicular or sebaceous differentiation are considered to show an immature stage of apocrine differentiation still rich in stem cells or to originate from stem cells with an incompletely established apocrine fate.
  • [MeSH-major] Apocrine Glands / metabolism. Keratins / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adult. Aged. Biomarkers, Tumor. Case-Control Studies. Cystadenoma / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16469077.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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13. Arias D, Castellano VM, Córdoba S, Miñano R, Martínez D, Borbujo JM: [Atypical presentation of syringocystoadenoma papilliferum]. Actas Dermosifiliogr; 2006 Dec;97(10):647-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Siringocistoadenoma papilífero de presentación atípica.
  • Syringocystoadenoma papilliferum is benign adnexal tumor derived from the sweat glands that is located in the head and neck in 70-80% of patients, and commonly presents as a papule or a solitary nodule.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Neoplasms, Second Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17173827.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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14. Ogawa R, Mitsuhashi K, Oki K, Hyakusoku H: A rare case of chondroid syringoma arising from the lower eyelid with ectropion. Plast Reconstr Surg; 2006 Nov;118(6):137e-140e
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eyelids. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17051093.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Agarwal S, Agarwal K, Kathuria P, Jain M, Chauhan DS, Prakash O: Cytomorphological features of nodular hidradenoma highlighting eccrine differentiation: a case report. Indian J Pathol Microbiol; 2006 Jul;49(3):411-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological features of nodular hidradenoma highlighting eccrine differentiation: a case report.
  • We report a case of nodular hidradenoma in a 90 year old male, presenting with an eyelid swelling.
  • The cytomorphological features are described with special emphasis on cytoplasmic granularity and tubule formation as an important feature in diagnosing and differentiating eccrine tumors from other adnexal neoplasms on FNAC.
  • [MeSH-major] Acrospiroma / pathology. Eyelids / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17001903.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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16. Petersson F, Kutzner H, Spagnolo DV, Bisceglia M, Kacerovska D, Vazmitel M, Michal M, Kazakov DV: Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2009 Oct;31(7):642-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spiradenoma is a benign, morphologically well-defined cutaneous adnexal neoplasm that is closely related to cylindroma.
  • The ACC-like areas were typified by cribriform formations of epithelial cells concentrically arranged around gland-like spaces filled with mucin, homogeneous eosinophilic material, or granular basophilic material.
  • It is concluded that the ACC-like pattern, although a rare feature and of no clinical consequence, is a distinctive finding in a minority of cases and extends the morphological spectrum of spiradenoma and spiradenocylindroma occurring sporadically or in the setting of Brooke-Spiegler syndrome.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19633533.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. Philipone E, Chen S: Unique case: syringocystadenoma papilliferum associated with an eccrine nevus. Am J Dermatopathol; 2009 Dec;31(8):806-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unique case: syringocystadenoma papilliferum associated with an eccrine nevus.
  • Syringocystadenoma papilliferum is a benign adnexal lesion of the skin most commonly found in the head and neck region.
  • It is frequently seen in association with other benign adnexal lesions.
  • We report a case of syringocystadenoma papilliferum seen in conjunction with an eccrine nevus.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Child, Preschool. Female. Humans. Skin Neoplasms / pathology


18. Kazakov DV, Nemcova J, Mikyskova I, Belousova IE, Vazmitel M, Michal M: Human papillomavirus in lesions of anogenital mammary-like glands. Int J Gynecol Pathol; 2007 Oct;26(4):475-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The lesions included 3 fibroadenomas, 2 adenosis tumors, 1 invasive ductal carcinoma, 1 tubulolobular carcinoma, 2 hidradenoma papilliferum with prominent cystic change rendering a cystadenoma appearance and oxyphilic metaplasia, and 7 cases of extramammary Paget disease.
  • All 3 fibroadenomas, both adenosis tumors, both hidradenoma papilliferum, and the tubulolobular carcinoma proved negative for HPV DNA.
  • In 2 of the 7 patients with extramammary Paget disease, there was HPV DNA present in the lesional tissue, typed as HPV-6 (LiPA) and a type which was closely related to HPV-21 and HPV-24 (FAP 6085-6319), whereas the remaining 5 cases tested negative.

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  • (PMID = 17885501.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Ozawa T, Fujiwara M, Nose K, Muraoka M: Clear-cell hidradenoma of the forearm in a young boy. Pediatr Dermatol; 2005 Sep-Oct;22(5):450-2
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  • [Title] Clear-cell hidradenoma of the forearm in a young boy.
  • We treated a 5-year-old boy with clear-cell hidradenoma of the forearm.
  • Our literature search found only one previous report of this disease occurring during the first decade of life, and the present patient is the first with involvement of the limbs.
  • This presentation demonstrates that clear-cell hidradenoma needs to be considered in the differential diagnosis of cutaneous tumors even in young children, which is of interest because malignant transformation can occur.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16191000.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Yosepovich A, Perelman M, Ayalon S, Papa M, Kopolovic J: Syringomatous adenoma of the nipple: a case report. Pathol Res Pract; 2005;201(5):405-7
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  • [Title] Syringomatous adenoma of the nipple: a case report.
  • Histological examination revealed the morphologic and immunohistochemical pattern of syringomatous adenoma of the nipple.
  • This is a rare lesion of the breast that can clinically mimic breast carcinoma, but harbors a benign and only locally aggressive course.
  • [MeSH-major] Breast Neoplasms / pathology. Nipples. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 16047951.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins
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21. Lee SY, Hwang SS, Kim HJ, Jung JH: Eccrine acrospiroma of inguinal area: Computed tomography findings. J Comput Assist Tomogr; 2006 Mar-Apr;30(2):223-5
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  • [Title] Eccrine acrospiroma of inguinal area: Computed tomography findings.
  • Eccrine acrospiroma is a tumor originating from the sweat glands.
  • The computed tomography findings of eccrine acrospiroma in the right inguinal area are presented.
  • Eccrine acrospiroma should be considered in the differential diagnosis of a subcutaneous cystic mass with an internal solid nodule.
  • [MeSH-major] Acrospiroma / radiography. Sweat Gland Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 16628036.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Tronnier M, Vogelbruch M: Atypical fibroxanthoma arising in an area of syringocystadenoma papilliferum associated with nevus sebaceus: positivity of the atypical fibroxanthoma component for CD31. J Cutan Pathol; 2007 Dec;34 Suppl 1:58-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cystadenoma / pathology. Hamartoma / pathology. Sweat Gland Neoplasms / pathology. Xanthomatosis / pathology

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  • (PMID = 17997741.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Biomarkers, Tumor
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23. Yoshida A, Takahashi K, Maeda F, Akasaka T: Multiple vascular eccrine spiradenomas: a case report and published work review of multiple eccrine spiradenomas. J Dermatol; 2010 Nov;37(11):990-4
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  • [Title] Multiple vascular eccrine spiradenomas: a case report and published work review of multiple eccrine spiradenomas.
  • Eccrine spiradenoma (ES) usually occurs as a solitary small nodule.
  • We present a rare case of a 55-year-old woman who had a 48-year history of multiple vascular eccrine spiradenomas (VES) localized on the left side of the submandibular region and neck.
  • All five tumors were skin-colored or pinkish-purple, and ranged in size 1.5-2.5 cm.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Eccrine Glands / blood supply. Eccrine Glands / pathology. Female. Head and Neck Neoplasms / pathology. Humans. Middle Aged. Tomography, X-Ray Computed / methods

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  • [Copyright] © 2010 Japanese Dermatological Association.
  • (PMID = 21039789.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
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24. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Transliterated title] Siringoma condroide: revisión clínica e histológica de ocho casos.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • It can be classified as eccrine and apocrine according to its pathological characteristics.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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25. Kamakura T, Horii A, Mishiro Y, Takashima S, Kubo T: Magnetic resonance imaging of syringocystadenoma papilliferum of the external auditory canal. Auris Nasus Larynx; 2006 Mar;33(1):53-6
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  • Signal intensities on T2-weighted images of this tumor were low compared to those of pleomorphic adenoma.
  • All ceruminous gland tumors including SCAP are thought to be potentially malignant; therefore, pre-operative biopsy should not be performed.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External / pathology. Magnetic Resonance Imaging. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 16168591.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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26. Ko CJ, Cochran AJ, Eng W, Binder SW: Hidradenocarcinoma: a histological and immunohistochemical study. J Cutan Pathol; 2006 Nov;33(11):726-30
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  • The diagnosis of hidradenocarcinoma is difficult due to a combination of factors including inconsistent nomenclature/ classification, rarity of the neoplasm, and variable morphology of cells composing the neoplasm.
  • We evaluated six cases of hidradenocarcinoma histologically and immunohistochemically using antibodies to gross cystic disease fluid protein-15 (GCDFP-15), carcino-embryonic antigen (CEA), epithelial membrane antigen (EMA), S-100 protein, keratin AE1/3, cytokeratin 5/6, p53, bcl-1, bcl-2, and Ki67.
  • Histology suggested concurrent eccrine and apocrine differentiation of the cases.
  • In making the diagnosis of hidradenocarcinoma, it may be unnecessary to separate hidradenocarcinoma into eccrine and apocrine categories, and although Ki67 and p53 may be helpful, histological parameters remain paramount.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Ki-67 Antigen / metabolism. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17083691.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; 68238-35-7 / Keratins
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27. Cho KE, Son EJ, Kim JA, Youk JH, Kim EK, Kwak JY, Jeong J: Clear cell hidradenoma of the axilla: a case report with literature review. Korean J Radiol; 2010 Jul-Aug;11(4):490-2
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  • [Title] Clear cell hidradenoma of the axilla: a case report with literature review.
  • Clear cell hidradenoma is an uncommon benign skin appendageal tumor that typically involves the dermal layer of the head, face, and extremities.
  • We present a case of clear cell hidradenoma of the axillary tail with radiological findings and a literature review.
  • [MeSH-major] Adenoma, Sweat Gland / radiography. Adenoma, Sweat Gland / ultrasonography. Axilla. Sweat Gland Neoplasms / radiography. Sweat Gland Neoplasms / ultrasonography

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  • [Cites] Br J Radiol. 2007 Jan;80(949):e27-9 [17267467.001]
  • [Cites] Breast Cancer. 2007;14(3):307-11 [17690510.001]
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  • (PMID = 20592936.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2893323
  • [Keywords] NOTNLM ; Axilla mass / Hidradenoma / Ultrasonography
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28. Teschner M, Buhr T, Donnerstag F, Lenarz T, Majdani O: [Expansion of an ceruminous adenoma into the middle ear]. Laryngorhinootologie; 2006 Jun;85(6):444-7
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  • [Title] [Expansion of an ceruminous adenoma into the middle ear].
  • Pathohistology revealed a ceruminal gland adenoma.
  • They are a rare phenomenon and should be distinguished from middle ear adenomas, pleomorph ceruminal gland adenomas, ceruminal gland adenocarcinomas and cylindromas of the ceruminal glands.
  • Despite its rare occurrence, a ceruminal gland adenoma must be taken into consideration in the differential diagnosis of individual cholesteatoma cases.
  • [MeSH-major] Adenoma / diagnosis. Apocrine Glands / pathology. Carcinoma, Squamous Cell / diagnosis. Cerumen. Ear Canal / pathology. Ear Neoplasms / diagnosis. Ear, Middle / pathology. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16770841.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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29. Mattoch IW, Pham N, Robbins JB, Bogomilsky J, Tandon M, Kohler S: Reactive eccrine syringofibroadenoma arising in peristomal skin: An unusual presentation of a rare lesion. J Am Acad Dermatol; 2008 Apr;58(4):691-6
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  • [Title] Reactive eccrine syringofibroadenoma arising in peristomal skin: An unusual presentation of a rare lesion.
  • We report the third case of eccrine syringofibroadenoma (ESFA) arising in peristomal skin.
  • Although ESFA is considered to be benign, recent reports have demonstrated an association of ESFA with malignancy or malignant transformation of ESFA.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Enterostomy / adverse effects. Fibroadenoma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18342718.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Volmar KE, Cummings TJ, Wang WH, Creager AJ, Tyler DS, Xie HB: Clear cell hidradenoma: a mimic of metastatic clear cell tumors. Arch Pathol Lab Med; 2005 May;129(5):e113-6
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  • [Title] Clear cell hidradenoma: a mimic of metastatic clear cell tumors.
  • Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma.
  • Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma.
  • Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation.
  • We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 15859654.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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31. Angulo J, González-Guerra E, Vargas-Machuca I, Fariña MC, Martín L, Requena L: [Multiple linear spiradenoma with a linear distribution]. Actas Dermosifiliogr; 2006 Jan-Feb;97(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16540048.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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32. Nazarian RM, Kapur P, Rakheja D, Piris A, Duncan LM, Mihm MC Jr, Hoang MP: Atypical and malignant hidradenomas: a histological and immunohistochemical study. Mod Pathol; 2009 Apr;22(4):600-10
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  • The histological features of atypical hidradenoma are worrisome for increased risk of recurrence and possible malignant potential; however, earlier studies with immunohistochemistry or patient follow-up have not been reported.
  • We compare the histological features and Ki-67, phosphorylated histone H3, epidermal growth factor receptor, and Her2/neu expression profiles of 15 atypical and 15 malignant hidradenomas with those of benign hidradenoma and metastasizing adnexal carcinomas.
  • Significant difference in mean Ki-67% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.002), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (0.002).
  • Significant difference in mean phosphorylated histone H3% was observed between benign and malignant hidradenomas (P<0.001), benign and metastasizing adnexal carcinomas (0.003), atypical and malignant hidradenomas (P<0.001), and between atypical hidradenomas and metastasizing adnexal carcinomas (P<0.001).
  • Mean epidermal growth factor receptor total score was significantly different in benign and atypical hidradenoma when compared with that in metastasizing adnexal carcinoma (P=0.014 and 0.019, respectively).
  • A tumor with Ki-67>11% and/or phosphorylated histone H3>0.7% would likely be a malignant rather than an atypical hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Biomarkers, Tumor / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 19252473.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Histones; 0 / Ki-67 Antigen; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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33. Toulemonde A, Croue A, Rodien P, Verret JL: [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient]. Ann Dermatol Venereol; 2006 Dec;133(12):1005-8
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  • [Title] [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient].
  • BACKGROUND: We report a case of multiple benign nodular hidradenomas associated with malignant nodular hidradenoma in a hypogonadic patient.
  • CASE-REPORT: A 49 year-old man presented 11 benign nodular hidradenomas in the pectoral region.
  • A malignant nodular hidradenoma had recently appeared in this region some distance from the pre-existing benign modular hidradenomas.
  • Large numbers of estrogen receptors were demonstrated in each of the benign nodular hidradenomas.
  • The malignant nodular hidradenoma mass was unavailable and screening for these receptors was not possible.
  • DISCUSSION: Cases of multiple nodular hidradenoma are extremely rare: we have seen only two.
  • To the best of our knowledge, there have been no reports to date of combined malignant nodular hidradenoma and multiple benign nodular hidradenoma.
  • However, the presence of estrogen receptors has occasionally been demonstrated in benign nodular hidradenomas.
  • Our patient's endocrine disease may have played a role in the presentation of multiple hidradenomas, but this cannot be demonstrated.
  • [MeSH-major] Adenoma, Sweat Gland / complications. Hypogonadism / complications. Sweat Gland Neoplasms / complications

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  • (PMID = 17185934.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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34. Ragunatha S, Inamadar AC, Annam V, Yelikar BR: A bluish nodule on the arm. Indian J Dermatol Venereol Leprol; 2008 Jan-Feb;74(1):83-5
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  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Pigmentation. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18187841.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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35. Khoury T, Balos L, McGrath B, Wong MK, Cheney RT, Tan D: Malignant glomus tumor: a case report and review of literature, focusing on its clinicopathologic features and immunohistochemical profile. Am J Dermatopathol; 2005 Oct;27(5):428-31
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  • To date, forty-five cases of MGT of skin and soft issue have been reported in the literature.
  • In this report, we emphasize the differential diagnosis of MGT in the skin and deep soft tissue.
  • [MeSH-major] Glomus Tumor / secondary. Skin Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Diagnosis, Differential. Female. Hand / pathology. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16148414.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Kim MS, Lee JH, Lee WM, Son SJ: A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. Ann Dermatol; 2010 Aug;22(3):319-22
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  • [Title] A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus.
  • Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor.

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  • [Cites] J Cutan Pathol. 1976;3(2):75-87 [993400.001]
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  • (PMID = 20711270.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917687
  • [Keywords] NOTNLM ; Nevus sebaceus / Syringocystadenoma papilliferum / Tubular apocrine adenoma
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37. Dubb M, Michelow P: Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol; 2009 Mar-Apr;53(2):179-82
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  • [Title] Cytologic features of hidradenoma in fine needle aspiration biopsies.
  • OBJECTIVE: To review the cytologic features of hidradenoma to describe criteria that may aid in identification of these tumors at the time of aspiration and allow for a more specific diagnosis than the umbrella term of benign skin adnexal tumor.
  • Fine needle aspiration (FNA) of these lesions showed the presence of benign skin adnexal tumors.
  • RESULTS: The following cytomorphologic findings are consistent with the diagnosis of hidradenoma: a cystic component to the aspirate as represented by amorphous background material with or without foam cells and epithelial duct-like cells and tubular structures.
  • CONCLUSION: Knowledge of the cytologic features of hidradenoma will allow for correct management of the patient and prevent misdiagnosis as a malignant tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19365971.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T: Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer; 2007 Sep;46(9):813-9
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  • MLL-MAML2 in secondary AML/MDS and MECT1-MAML2 in mucoepithelioid carcinoma, benign Wartin's tumor, and clear cell hidradenoma consist of the same COOH-terminal part of MAML2.


39. Tey HL, Chong WS, Wong SN: Leprosy-associated eccrine syringofibroadenoma of Mascaro. Clin Exp Dermatol; 2007 Sep;32(5):533-5
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  • [Title] Leprosy-associated eccrine syringofibroadenoma of Mascaro.
  • Eccrine syringofibroadenoma of Mascaro is a rare benign tumour.
  • Histology was consistent with eccrine syringofibroadenoma.
  • To our knowledge, this is the first reported case of multiple eccrine syringofibroadenomata occurring in association with leprosy.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Fibroadenoma / pathology. Leprosy, Lepromatous / complications. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Age Factors. Aged. Disease Progression. Female. Follow-Up Studies. Humans

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  • (PMID = 17459067.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Gatti A, di Meo N, Trevisan G: Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. Acta Dermatovenerol Alp Pannonica Adriat; 2010 Dec;19(4):23-5
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  • [Title] Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma.
  • Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Melanoma / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


41. Singh A, Sharma S, Verma S, Khanna A: Malignant nodular hidradenoma with angiolymphatic invasion: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):548-9
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  • [Title] Malignant nodular hidradenoma with angiolymphatic invasion: a case report.
  • Malignant nodular hidradenomas are rare variants of sweat gland carcinomas characterized by aggressive clinical behaviour.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aneuploidy. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Skin Neoplasms / secondary

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  • (PMID = 17883130.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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42. Smiri KH, Fenniche S, Marrak H, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I: [Chondroid syringoma]. Tunis Med; 2005 Jun;83(6):372-4
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  • All patients presented with a single painless skin lesion of about 1,5 cm on the face, lasting for 14 months on average.
  • Chondroid syringoma is a benign sweat gland tumor.
  • Diagnosis can always be confirmed by histology which shows tubuloalveolar and gland like structures with two or more cuboidal cell lines in a fibroadipoid or chondroid stroma that is positively stained for Alcian blue.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Disease Progression. Humans. Male. Middle Aged. Patient Satisfaction. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 16156416.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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43. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Title] Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • An alternative theory holds that pleomorphic adenomas may well arise from ectopic salivary tissue present in the external ear canal.
  • These tumors are very rare and usually have a benign course.
  • In this report, we describe an unusual case of pleomorphic adenoma of the external auditory canal associated with chronic infection of the middle ear.
  • Subsequent biopsy and histologic examination revealed pleomorphic adenoma of the external ear canal, possibly with malignant elements.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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44. Retamar RA, Stengel F, Saadi ME, Kien MC, Della Giovana P, Cabrera H, Chouela EN: Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser. Int J Dermatol; 2007 Jun;46(6):583-6
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  • BACKGROUND: Brooke-Spiegler syndrome is a well known but rare cutaneous disorder characterized by the presence of multiple trichoepitheliomas and cylindromas.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Carcinoma, Adenoid Cystic / surgery. Laser Therapy. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms / surgery

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  • (PMID = 17550556.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Novak NP, Kaić G, Tomasović-Loncarić C, Zic R, Skoro M, Ostović KT: Fine-needle aspiration cytology of apocrine hidradenoma. Coll Antropol; 2010 Jun;34(2):671-4
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  • [Title] Fine-needle aspiration cytology of apocrine hidradenoma.
  • An apocrine hidradenoma is a benign adnexal neoplasm, usually covered by intact skin, but may show superficial ulceration and serous discharge.
  • We described cytomorphologic features of cutaneous nodule that might be a lead to the cytologic diagnosis of hidradenoma, but primary or secondary malignant tumour has been ruled out first.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 20698151.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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46. Choudhury M, Agarwal C, Aggarwal M, Pathania OP, Goel N: Clinicopathological profile of an unusual case of chondroid syringoma: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):349-51
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  • Chondroid syringoma or mixed tumor of the skin is an uncommon tumor that typically presents as small, solitary, slow growing, firm, subcutaneous or intracutaneous nodule.
  • FNAC and excision biopsy revealed benign chondroid syringoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 17883069.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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47. Baumhoer D, Pförtner R, Mohr C, Jundt G: Tubulopapillary hidradenoma-like tumor of the mandible. Int J Oral Maxillofac Surg; 2009 Aug;38(8):903-7
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  • [Title] Tubulopapillary hidradenoma-like tumor of the mandible.
  • Tubulopapillary hidradenomas are uncommon benign tumors of the dermis, most commonly occurring in the skin of the head or of the extremities.
  • The authors describe an unusual case of an intraosseous tubulopapillary hidradenoma of the mandible that recurred 1 year after initial curettage and required en-bloc resection.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Mandibular Neoplasms / diagnosis

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  • (PMID = 19375892.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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48. Schaller J, Rytina E, Rütten A, Hendricks C, Ha T, Requena L: Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases. J Cutan Pathol; 2010 Sep;37(9):1002-9
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  • [Title] Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases.
  • Both from a clinical and from a histopathological point of view, our two cases showed some similarities with those previously described in patients with Nicolau-Balus syndrome, Rombo syndrome, and so-called eccrine-pilar hamartoma.
  • Dermatologists and dermatopathologists should be aware of this disorder to avoid overdiagnosis of and inappropriate treatment for MAC.
  • [MeSH-major] Adenoma / diagnosis. Facial Dermatoses / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / diagnosis. Skin / pathology. Sweat Glands / pathology
  • [MeSH-minor] Adult. Atrophy / pathology. Biopsy. Cell Proliferation. Diagnosis, Differential. Elastic Tissue / pathology. Female. Hamartoma / diagnosis. Humans. Male. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 20175822.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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49. Page RN, Dittrich L, King R, Boulos F, Page DL: Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report. J Cutan Pathol; 2009 Nov;36(11):1206-9
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  • [Title] Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report.
  • Originally described by Rosen in 1983, syringomatous nipple adenoma (SAN) is a tumor of disputed histogenesis, which can be problematic both diagnostically and therapeutically.
  • It is a benign primary tumor of breast epithelium with histology similar to that of the syringoma.
  • This case represents, to our knowledge, the first such reported case, and represents a significant finding as its presence could lend some confusion as to whether or not this represents a benign primary process of breast or a potentially infiltrative tumor of the skin.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Nipples / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19469876.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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50. Kazakov DV, Mikyskova I, Kutzner H, Simpson RH, Hes O, Mukensnabl P, Bouda J, Zamecnik M, Kinkor Z, Michal M: Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus. Am J Dermatopathol; 2005 Apr;27(2):102-10
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  • [Title] Hidradenoma papilliferum with oxyphilic metaplasia: a clinicopathological study of 18 cases, including detection of human papillomavirus.
  • Reported here are 18 cases of hidradenoma papilliferum with oxyphilic metaplasia.
  • This finding could be likened to apocrine metaplasia, a term used in breast pathology.
  • Other histopathological findings observed in this series, analogous to benign breast disease, included sclerosing adenosis-like changes, atypical apocrine adenosis-like changes, changes corresponding to usual ductal epithelial hyperplasia, epitheliomatosis with a streaming growth pattern, lamprocyte-like changes, clear cell change of the myoepithelium, foamy histiocyte reaction, and stromal fibrosis.
  • Using 2 different PCR methods we identified HPV in 4 of 15 cases of hidradenoma with oxyphilic metaplasia.
  • Our observations are consistent with previous publications noting similarities between tumors of the breast and sweat glands.
  • Oxyphilic metaplasia, areas with solid growth, and changes simulating atypical apocrine adenosis are rare and poorly recognized in hidradenoma papilliferum and may cause diagnostic difficulties; in our cases several submitting pathologists suspected malignancy.
  • A causal role for HPV in hidradenoma papilliferum cannot be confirmed from our results, as the detection rate is too low.
  • [MeSH-major] Adnexal Diseases / pathology. Metaplasia / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Adult. Aged. Animals. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Papillomaviridae. Papillomavirus Infections / complications. Papillomavirus Infections / pathology. Polymerase Chain Reaction

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  • (PMID = 15798433.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Gilaberte Y, Grasa MP, Carapeto FJ: Clear cell hidradenoma. J Am Acad Dermatol; 2006 May;54(5 Suppl):248-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma.
  • [MeSH-major] Acrospiroma / pathology. Leg. Sweat Gland Neoplasms / pathology

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  • [CommentOn] J Am Acad Dermatol. 2000 Apr;42(4):693-5 [10727324.001]
  • (PMID = 16631962.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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52. Tey HL: Characterizing the nature of eccrine syringofibroadenoma: illustration with a case showing spontaneous involution. Clin Exp Dermatol; 2009 Jul;34(5):e66-8
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  • [Title] Characterizing the nature of eccrine syringofibroadenoma: illustration with a case showing spontaneous involution.
  • Eccrine syringofibroadenoma (ESFA) is a histological entity.
  • Reactive ESFA represents a hyperplastic and hamartomatous process, and may be more appropriately known as reactive eccrine syringofibroadenomatosis.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Fibroadenoma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Eccrine Glands. Female. Humans. Leprosy, Lepromatous / complications. Neoplasm Regression, Spontaneous

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  • (PMID = 19438523.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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53. Gönül M, Soylu S, Gül U, Kaya I, Albayrak L, Unal T: Linear syringocystadenoma papilliferum of the arm: a rare localization of an uncommon tumour. Acta Derm Venereol; 2008;88(5):528-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18779904.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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54. Collman DR, Blasko M, Alonzo J, Stess R: Clear cell hidradenoma of the ankle. J Foot Ankle Surg; 2007 Sep-Oct;46(5):387-93
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  • [Title] Clear cell hidradenoma of the ankle.
  • Clear cell hidradenoma is a relatively common, benign eccrine neoplasm with rare presentations in the foot and ankle.
  • Variable clinical and histopathologic characteristics of the tumor warrant careful consideration over primary and recurrent malignancy, particularly eccrine carcinoma.
  • The first known case of primary benign clear cell hidradenoma of the ankle is presented with imaging studies, surgical management, and clinicopathologic correlation, distinguishing the neoplasm from its malignant counterparts.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Ankle / pathology. Foot Diseases / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17761324.001).
  • [ISSN] 1067-2516
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Yoshida Y, Nakashima K, Yamamoto O: Dermoscopic features of clear cell hidradenoma. Dermatology; 2008;217(3):250-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopic features of clear cell hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Dermoscopy. Sweat Gland Neoplasms / pathology

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  • (PMID = 18663309.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Switzerland
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56. Kauer F, Paasch U, Böer A, Blödorn-Schlicht N, Simon JC: [Dome shaped, in the center delled tumor with teleangiectasia]. J Dtsch Dermatol Ges; 2007 Jul;5(7):621-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17610613.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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57. Garcia-Bonafe MM, Campins MM, Redecilla PH: Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation. Acta Cytol; 2009 Sep-Oct;53(5):576-80
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  • [Title] Malignant nodular hidradenoma on the scalp: report of a case with fine needle aspiration cytology features and histologic correlation.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant adnexal tumor of the eccrine sweat glands.
  • The histology is similar to that of benign nodular hidradenoma, but MNH shows an infiltrative and invasive pattern, necrosis and angiolymphatic invasion.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Biopsy, Fine-Needle. Head and Neck Neoplasms / pathology. Scalp / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19798887.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Ko JY, Lee CW, Moon SH, Song KW, Park CK: Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. J Korean Med Sci; 2006 Feb;21(1):172-6
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  • [Title] Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study.
  • We report a rare case of giant vascular eccrine spiradenoma (GVES) which developed in 56-yr-old Korean woman.
  • It is a rare variant of eccrine spiradenoma (ES), which might be mistaken for angiomatous lesions in view of its florid vascularity and hemorrhagic features.
  • Histogenesis of GVES is not clearly elucidated although it is known that ES presumably originates in the eccrine glands.
  • Therefore, we conclude that GVES originated from eccrine gland and mainly differentiates toward secretory portion of secretory coil.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • [Cites] J Cutan Pathol. 1992 Aug;19(4):294-301 [1331211.001]
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  • (PMID = 16479087.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / CKAP4 protein, human; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Membrane Proteins; 0 / Mucin-1; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2733970
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59. Möller E, Stenman G, Mandahl N, Hamberg H, Mölne L, van den Oord JJ, Brosjö O, Mertens F, Panagopoulos I: POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands. J Pathol; 2008 May;215(1):78-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.
  • In the present study, we report the fusion of EWSR1 and POU5F1 in two types of epithelial tumours: hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands.
  • This finding not only broadens considerably the spectrum of neoplasms associated with EWSR1 fusion genes but also strengthens the evidence for shared pathogenetic mechanisms in the development of adnexal and salivary gland tumours.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Calmodulin-Binding Proteins / genetics. Carcinoma, Mucoepidermoid / metabolism. Octamer Transcription Factor-3 / genetics. RNA-Binding Proteins / genetics. Salivary Glands / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18338330.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / EWSR1 protein, human; 0 / Octamer Transcription Factor-3; 0 / Oncogene Proteins, Fusion; 0 / POU5F1 protein, human; 0 / RNA-Binding Proteins
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60. Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R: Syringocystadenoma papilliferum: report of 8 cases. Pathologica; 2006 Jun;98(3):178-80
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  • It arises in about one third of cases within a sebaceous hamartoma (SH) and in this case, multiple other benign adnexal neoplasms may be associated with it.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17036946.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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61. Lee CK, Jang KT, Cho YS: Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. J Laryngol Otol; 2005 Dec;119(12):1004-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal.
  • Tubular apocrine adenoma (TAA) is a very rare sweat gland tumour.
  • [MeSH-major] Adenoma / pathology. Ear Canal / pathology. Ear Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16354370.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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62. Monteagudo B, Antón-Badiola IM, Muñoz MJ, Paredes-Suárez C, Vázquez-Blanco M: [Pigmented apocrine hidradenoma]. Actas Dermosifiliogr; 2005 Jan-Feb;96(1):50-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pigmented apocrine hidradenoma].
  • Apocrine hidradenoma is a benign adnexal neoplasm.
  • The same as other tumors of the sweat glands, there is a pigmented variety.
  • After the histopathological study, the diagnosis was established as pigmented apocrine hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Hyperpigmentation / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476334.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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63. Knoedler D, Susnik B, Gonyo MB, Osipov V: Giant apocrine hidradenoma of the breast. Breast J; 2007 Jan-Feb;13(1):91-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant apocrine hidradenoma of the breast.
  • The pathologic evaluation of the core biopsy and the subsequent excision specimen revealed a benign sclerosing, cystic, and papillary adnexal tumor with apocrine and clear cell morphology.
  • The final diagnosis was apocrine hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Breast Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17214802.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Goodden JR, Marven SS, Cohen M, de Ville McMullan PJ, Smith MF: Congenital apocrine tumour: a rare scalp tumour. Eur J Pediatr Surg; 2008 Aug;18(4):282-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a rare congenital scalp tumour with histological diagnosis of a congenital apocrine adenoma with features of a tubular adenoma.
  • [MeSH-major] Apocrine Glands. Head and Neck Neoplasms / congenital. Scalp. Skin Neoplasms / congenital. Sweat Gland Neoplasms / congenital

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  • (PMID = 18629773.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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65. Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer; 2005 Jun;43(2):202-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
  • Recent studies have shown that the t(11;19)(q21;p13) translocation in mucoepidermoid carcinomas and benign Warthin's tumors results in a fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a.
  • Here we show that a third tumor type, clear cell hidradenoma of the skin, also expresses this gene fusion.
  • RT-PCR analysis of a clear cell hidradenoma with a t(11;19)(q21;p13) translocation revealed expression of a TORC1-MAML2 fusion transcript consisting of exon 1 of TORC1 fused to exons 2-5 of MAML2.
  • These results demonstrate that the t(11;19) in mucoepidermoid carcinoma, Warthin's tumor, and clear cell hidradenoma targets the same genes and results in identical gene fusions, indicating that at least subgroups of these glandular tumors evolve through activation of the same molecular pathways.
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Nuclear Proteins / genetics. Skin Neoplasms / genetics. Transcription Factors / genetics. Translocation, Genetic

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15729701.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Transcription Factors
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66. Monteagudo B, Iglesias B, de la Torre C, Paredes C, Vázquez-Blanco M, Ginarte M, Labandeira J: [Poroid hidradenoma]. Actas Dermosifiliogr; 2005 Jul-Aug;96(6):398-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Poroid hidradenoma].
  • Poroid hidradenoma is a recently described variant of eccrine poroma.
  • This neoplasm presents structural findings of hidradenoma (solid and cystic areas) and cytological characteristics of poromas (poroid and cuticular cells, the latter showing ductal differentiation).
  • We present a case of poroid hidradenoma in a 74-year-old woman, who consulted her physician because of a nodular lesion on the left buttock.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476263.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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67. Angulo J, Jaqueti G, Kutzner H, Requena L: Squamous cell apocrine hidradenoma. J Cutan Pathol; 2007 Oct;34(10):801-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell apocrine hidradenoma.
  • Apocrine hidradenoma is a benign adnexal neoplasm with apocrine differentiation.
  • We report two cases of apocrine hidradenoma mostly composed of squamous cells.
  • The rare cases described in this report are exceptional because most of the neoplastic cells showed squamous appearance and for that reason we think that squamous cell apocrine hidradenoma is the most appropriate name for these neoplasms.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Squamous Cell / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17880588.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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68. El Demellawy D, Daya D, Alowami S: Clear cell hidradenoma: an unusual vulvar tumor. Int J Gynecol Pathol; 2008 Jul;27(3):457-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell hidradenoma: an unusual vulvar tumor.
  • Clear cell hidradenoma (CCH) is a benign skin appendageal tumor.
  • Most cases occur in the skin of the head and face.
  • Although most cases are benign, occasional cases with malignant transformation have been reported.
  • Although rare, inclusion of CCH should be included in the differential diagnosis of benign solid and clear cell tumors of the vulvar skin.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18580328.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A: Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature. Int J Dermatol; 2006 Oct;45(10):1218-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17040446.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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70. Alkatan HM: Nodular hidradenoma of the lower eyelid. Can J Ophthalmol; 2007 Feb;42(1):149-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodular hidradenoma of the lower eyelid.

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  • (PMID = 17361265.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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71. Biedrzycki OJ, Rufford B, Wilcox M, Barton DP, Jameson C: Malignant clear cell hidradenoma of the vulva: report of a unique case and review of the literature. Int J Gynecol Pathol; 2008 Jan;27(1):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant clear cell hidradenoma of the vulva: report of a unique case and review of the literature.
  • Clear cell hidradenoma (CCH) is a rare tumor derived from eccrine sweat glands with a predilection for the head, face, and upper extremities.
  • A previously healthy 39-year-old woman underwent marsupialization of a presumed left-side vulval Bartholin gland cyst.
  • It also highlights the importance of considering MCCH in the differential diagnosis of a lymph node containing a metastatic clear cell tumor or an apparent metastatic clear cell lesion in the skin.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18156989.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. Chase DM, Basu T, Saffari B, Ries S, Berman ML: Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. Int J Gynecol Cancer; 2006 May-Jun;16(3):1465-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant eccrine spiradenoma of the vulva: a case report and review of the literature.
  • Malignant eccrine spiradenoma is a rare skin tumor of sweat gland origin.
  • The present case is that of a 41-year-old woman with malignant eccrine spiradenoma of the periclitoral region.
  • As malignant eccrine spiradenoma is a rare tumor, no standard care exists for treatment and postoperative management.
  • Therefore, these patients require close postoperative follow-up for recurrent disease.
  • [MeSH-major] Acrospiroma / diagnosis. Sweat Gland Neoplasms / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Adenoma, Sweat Gland / diagnosis. Adult. Female. Humans. Neoplasm Recurrence, Local / prevention & control. Sentinel Lymph Node Biopsy / methods

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  • (PMID = 16803551.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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73. Mebazaa A, Trabelsi S, Denguezli M, Sriha B, Belajouza C, Nouira R: Chondroid syringoma of the arm: an unusual localization. Dermatol Online J; 2006;12(1):14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma (CS) is an uncommon, benign, sweat-gland tumor.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Arm. Sweat Gland Neoplasms / pathology

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  • (PMID = 16638382.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Verret DJ, Kabbani W, DeFatta RJ: Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. Head Neck; 2007 Feb;29(2):193-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation.
  • BACKGROUND: Nodular hidradenocarcinoma (NHAC), an eccrine carcinoma, has been reported in the dermatology and pathology literature, but few references have been made in the otolaryngology literature even though the head and neck is a common site of occurrence.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Parotid Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17103407.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Bollée G, Patey N, Cazajous G, Robert C, Goujon JM, Fakhouri F, Bruneval P, Noël LH, Knebelmann B: Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib. Nephrol Dial Transplant; 2009 Feb;24(2):682-5
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  • A 44-year-old woman with a history of malignant skin hidradenoma was started on sunitinib for refractory disease.
  • [MeSH-minor] Adenoma, Sweat Gland / drug therapy. Adult. Antineoplastic Agents / adverse effects. Female. Humans. Protein Kinase Inhibitors / adverse effects. Skin Neoplasms / drug therapy

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  • [CommentIn] Nephrol Dial Transplant. 2009 Jun;24(6):2002-3 [19332867.001]
  • (PMID = 19054798.001).
  • [ISSN] 1460-2385
  • [Journal-full-title] Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • [ISO-abbreviation] Nephrol. Dial. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Protein Kinase Inhibitors; 0 / Pyrroles; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / sunitinib
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76. Ekmekci TR, Koslu A, Sakiz D: Congenital blaschkoid eccrine spiradenoma on the face. Eur J Dermatol; 2005 Mar-Apr;15(2):73-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital blaschkoid eccrine spiradenoma on the face.
  • Eccrine spiradenoma is an uncommon tumour of the sweat gland(s) and generally occurs as a solitary small painful nodule.
  • Histopathologic examination of a biopsy specimen revealed characteristic features of eccrine spiradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / congenital. Eccrine Glands / pathology. Face. Sweat Gland Neoplasms / congenital

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  • (PMID = 15757814.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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77. Ogawa R, Akaishi S, Hyakusoku H: Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg; 2009 Jun;62(6):660-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All tumors were benign: apocrine cystadenoma, adult-onset juvenile xanthogranuloma, mixed tumor, and chronic folliculitis.
  • (1) biopsy should be conducted in anomalous cases because malignant disease may be the original or secondary problem, (2) steroid injection should be performed only after careful consideration because malignancy or infections may be present, (3) careful differential diagnosis is particularly challenging in African-Americans because skin and tumor color are often similar, and (4) the presence of bacterial or fungal infection should be investigated.
  • [MeSH-major] Cicatrix, Hypertrophic / diagnosis. Keloid / diagnosis. Skin Diseases / diagnosis
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adult. Cystadenoma / pathology. Diagnosis, Differential. Folliculitis / pathology. Humans. Male. Middle Aged. Sweat Gland Neoplasms / pathology. Xanthogranuloma, Juvenile / pathology. Young Adult

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  • (PMID = 19461281.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Abdulla AN, Covert AA, Grantmyre JE: Scrotal syringocystadenoma papilliferum: case report. Can J Urol; 2009 Jun;16(3):4684-6
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  • Syringocystadenoma papilliferum (SCAP) is a benign rare adnexal skin neoplasm, which in a third of cases arises from a nevus sebaceous and is most commonly found on the head and neck and in very rare instances found on the genitalia.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Scrotum / pathology. Skin Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19497181.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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79. Lee JS, Chang KC, Chen HH, Sze CI: Malignant sweat gland tumor presenting as an unusual dural-based lesion: case report. J Neurooncol; 2010 Sep;99(2):273-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant sweat gland tumor presenting as an unusual dural-based lesion: case report.
  • Malignant sweat gland tumors are rare neoplasms with high recurrence and metastasis rates of over 50%.
  • Given the lack of scalp or skull bone involvement, we speculated that the tumor may have arisen from ectopic sweat gland cells entrapped in the dural mater.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Brain Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [Cites] J Clin Pathol. 2007 Feb;60(2):145-59 [16882695.001]
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  • (PMID = 20069341.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Sirivella S, Gielchinsky I: Chondroid syringoma: a rare tumor of the chest wall. Ann Thorac Surg; 2010 Mar;89(3):983-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma, an uncommon, slow-growing, benign, sweat-gland tumor located on the upper right chest wall of a 66-year-old woman is presented.
  • This skin adenexal tumor is typically located on the head and neck region.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20172178.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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81. Durairaj VD, Bartlett HM, Said S: Malignant hidradenoma of the medial canthus with orbital and intracranial extension. Ophthal Plast Reconstr Surg; 2006 May-Jun;22(3):229-32
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  • [Title] Malignant hidradenoma of the medial canthus with orbital and intracranial extension.
  • A diagnosis of malignant hidradenoma of the medial canthus was confirmed by histopathology.
  • Despite aggressive therapy, the patient developed metastatic disease and died within 1 year.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Brain Neoplasms / secondary. Eyelid Neoplasms / pathology. Orbital Neoplasms / secondary. Paranasal Sinus Neoplasms / secondary

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  • (PMID = 16714943.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Siegel HJ, Said-Al-Naief N, Long J, Lopez-Ben RR, Klein M: Giant eccrine spiradenoma of the hand. Am J Orthop (Belle Mead NJ); 2008 Aug;37(8):E141-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant eccrine spiradenoma of the hand.
  • [MeSH-major] Adenoma, Sweat Gland. Hand

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  • (PMID = 18836612.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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83. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • Benign tumors demonstrating both spiradenomatous and cylindromatous features have been infrequently reported.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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84. Yu G, Goodloe S Jr, D'Angelis CA, McGrath BE, Chen F: Giant clear cell hidradenoma of the knee. J Cutan Pathol; 2010 Sep;37(9):e37-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant clear cell hidradenoma of the knee.
  • Hidradenomas, also referred to as nodular hidradenomas or clear cell hidradenomas (CCH), are benign cutaneous eccrine tumors usually 2-3 cm in dimension.
  • We report a case of an 8.0 x 6.0 x 3.0 cm clear cell hidradenoma of the left knee in a 43-year-old man.
  • Grossly, the resected tumor was unencapsulated and tan, with a solid and cystic cut surface showing papillary excrescences on the cyst wall.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19615032.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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85. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • The commonest variants are those of eccrine sweat gland origin.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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86. Lin D, Perri AJ 3rd, Weaver JM, Colome MI, Raimer SS: What is your diagnosis? Benign acrospiroma. Cutis; 2009 Jan;83(1):12, 21-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What is your diagnosis? Benign acrospiroma.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19271564.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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87. Kazakov DV, Vanecek T, Belousova IE, Mukensnabl P, Kollertova D, Michal M: Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast. Am J Dermatopathol; 2007 Oct;29(5):457-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: hidradenoma of the breast.
  • Skin adnexal type tumors situated in the parenchyma of the breast are very rare.
  • We report herein a case of solid-cystic hidradenoma of the breast.
  • The tumor was situated in the parenchyma of the breast of a 55-year-old female and showed no connection to the overlying skin on ultrasound and radiology investigations, grossly and microscopically.
  • This t(11;19) translocation has been reported in approximately 50% of hidradenomas of the skin.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Breast Neoplasms / genetics. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Translocation, Genetic / genetics

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  • (PMID = 17890914.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MECT1-MAML2 fusion protein, human; 0 / Oncogene Proteins, Fusion
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88. Liapakis IE, Korkolis DP, Koutsoumbi A, Fida A, Kokkalis G, Vassilopoulos PP: Malignant hidradenoma: a report of two cases and review of the literature. Anticancer Res; 2006 May-Jun;26(3B):2217-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant hidradenoma: a report of two cases and review of the literature.
  • INTRODUCTION: Malignant tumors of the sweat glands are very rare.
  • Clear cell hidradenoma is a lesion with histopathological features resembling those of eccrine poroma and eccrine spiradenoma.
  • Although he had received several chemotherapeutic agents, the disease had a relentless course and the patient succumbed two and a half years following surgery.
  • CONCLUSION: Malignant tumors of the sweat glands are very rare neoplasms with no discrete clinical characteristics.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16821590.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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89. Gonul M, Cakmak SK, Gul U, Han O, Karagece U: A skin tumor in a young girl. Diagnosis: Clear cell hidradenoma. Indian J Dermatol Venereol Leprol; 2010 Jul-Aug;76(4):445-6
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  • [Title] A skin tumor in a young girl. Diagnosis: Clear cell hidradenoma.
  • [MeSH-major] Acrospiroma / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 20657141.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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90. Akcay EK, Simsek S, Cagil N, Belenli O, Gumus M: Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus. Can J Ophthalmol; 2008 Oct;43(5):609-10
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  • [Title] Apocrine adenocarcinoma of the right eyelid and apocrine adenoma of the left maxillary sinus.

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  • (PMID = 18982051.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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91. Kazakov DV, Kutzner H, Spagnolo DV, Kempf W, Zelger B, Mukensnabl P, Michal M: Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma). Am J Dermatopathol; 2008 Feb;30(1):21-6
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  • Six lesions had the silhouette of a classical poroma, 3 of poroid hidradenoma and 1 of dermal duct tumor.
  • Our study supports previous findings that sebaceous differentiation can be identified not only in classical poroma but also in the related lesions known as dermal duct tumor and poroid hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Sebaceous Glands / pathology. Skin Neoplasms / pathology

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  • (PMID = 18212539.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Miyamoto T, Hagari Y, Inoue S, Watanabe T, Yoshino T: Axillary apocrine carcinoma with benign apocrine tumours: a case report involving a pathological and immunohistochemical study and review of the literature. J Clin Pathol; 2005 Jul;58(7):757-61
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  • [Title] Axillary apocrine carcinoma with benign apocrine tumours: a case report involving a pathological and immunohistochemical study and review of the literature.
  • AIMS/METHODS: Because benign apocrine tumours may be precursors of cancer, this case was investigated immunohistochemically and histologically, and a literature (English and Japanese) review undertaken of cases with coexistent malignant and benign apocrine tumours in the axilla to elucidate the relation between apocrine carcinoma and benign apocrine tumours.
  • RESULTS: Only four cases of axillary apocrine carcinoma with benign apocrine tumours were identified in the literature.
  • In each case, benign apocrine hyperplasia was situated within and surrounding the adenocarcinomatous nests.
  • CONCLUSIONS: All five apocrine carcinomas with benign apocrine tumours occurred in elderly Japanese men who had bilateral benign apocrine tumours even if affected by unilateral axillary apocrine carcinoma.
  • The immunohistochemical results support the notion that apocrine hyperplasia is a precursor of cancer and that apocrine carcinoma, adenoma, and hyperplasia may be successive steps in the linear progression to carcinoma.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Apocrine Glands / pathology. Precancerous Conditions / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Aged. Aged, 80 and over. Axilla. Humans. Hyperplasia. Male

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  • (PMID = 15976347.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 18
  • [Other-IDs] NLM/ PMC1770727
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93. Canedo T, de Almeida MP, Cuzzi T, Ramos-e-Silva M: Immunophenotypic aspects of cylindroma and nodular hidradenoma. J Eur Acad Dermatol Venereol; 2010 Feb;24(2):178-85
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  • [Title] Immunophenotypic aspects of cylindroma and nodular hidradenoma.
  • OBJECTIVES: To evaluate the eccrine and/or apocrine differentiation phenotype in cases of cylindroma and clear cell hidradenoma with CD15 and p63 antibodies.
  • METHODOLOGY: Slides and blocks of six cases of cylindroma and seven cases of nodular hidradenoma (clear cells) were analyzed by the technique of immunohistochemistry with CD15 and p63 antibodies.
  • In five of seven cases of nodular hidradenoma (clear cell), we could easily observe clear cells between 20% and 50% of tumour cells.
  • CONCLUSIONS: The present study suggests eccrine origin for both tumours: cylindroma and clear cell hidradenoma.
  • [MeSH-major] Acrospiroma / immunology. Carcinoma, Adenoid Cystic / immunology. Immunophenotyping

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  • (PMID = 19796089.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD15; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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94. Goh SG, Carr R, Dayrit JF, Calonje E: Mucinous hidradenoma: a report of three cases. J Cutan Pathol; 2007 Jun;34(6):497-502
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  • [Title] Mucinous hidradenoma: a report of three cases.
  • We describe three cases of mucinous hidradenoma characterized by diffuse and prominent mucinous cell proliferation and discuss the relevant literature.
  • The lesions were completely excised, and all patients were alive without evidence of disease (follow-up interval 3-4 years).
  • Case 1 presented as a 1.3-cm eyelid nodule and histology showed a mucinous apocrine hidradenoma with a proliferation of mucinous cells and apocrine glands.
  • The tumor was also interpretated as a mucinous hidradenoma, most likely of follicular-apocrine origin.
  • The histology showed a mucinous clear-cell hidradenoma composed of numerous mucinous glands amidst small squamous cells with clear cytoplasm and a hyalinized fibrovascular stroma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cystadenoma, Mucinous / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Eyelids / pathology. Female. Humans. Male. Scalp / pathology. Shoulder / pathology. Treatment Outcome

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  • (PMID = 17518780.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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95. Kazakov DV, Mukensnabl P, Michal M: Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol; 2006 Apr;28(2):142-6
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  • [Title] Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
  • The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues.
  • We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation.
  • The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia.
  • In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation.
  • Rare cases occurring in the sites normally devoid of apocrine glands may represent the eccrine counterpart.
  • [MeSH-major] Adenoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Back. Cell Differentiation. Cell Lineage. Eosinophils / pathology. Epithelial Cells / pathology. Epithelium / pathology. Female. Fibroblasts / pathology. Follow-Up Studies. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Humans. Middle Aged. Scalp / pathology. Sebaceous Glands / pathology

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  • (PMID = 16625077.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Guan Y, Xiao Y, Ji HA, Xue CW, Li P: [Poroid hidradenoma: a case report]. Zhonghua Bing Li Xue Za Zhi; 2006 Jun;35(6):378-9
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  • [Title] [Poroid hidradenoma: a case report].
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Skin Neoplasms / pathology

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  • (PMID = 16834920.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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97. Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R: Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology; 2009;41(4):372-8
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  • [Title] Mammary-like gland adenoma of the vulva: review of 46 cases.
  • AIMS: Hidradenoma papilliferum (HP) of the anogenital region, which was previously thought to be an apocrine tumour, is now believed to be derived from anogenital mammary-like glands (MLG) and is more accurately termed MLG adenoma.
  • Unusual architectural patterns resembled breast lesions such as erosive adenomatosis, sclerosing adenosis and ductal adenoma.
  • CONCLUSIONS: MLG adenomas demonstrate a marked diversity in histological pattern and cell morphology.
  • Unusual vulvar tumours, which have been previously reported as erosive adenomatosis, sclerosing adenosis, papillary adenofibroma, syringocystadenoma papilliferans, etc., are variants of MLG adenomas.
  • [MeSH-major] Adenoma / pathology. Mammary Glands, Human / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19404851.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 46
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98. Punia RP, Garg S, Bal A, Mohan H: Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. Dermatol Online J; 2008;14(1):15
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  • [Title] Pigmented nodular hidradenoma masquerading as nodular malignant melanoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18319032.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Puri PK, Galan A, Glusac EJ, Cowper SE: Metastatic cutaneous carcinoid tumor mimicking an adnexal poroid neoplasm. J Cutan Pathol; 2008 Jan;35(1):54-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Apocrine Glands / pathology. Carcinoid Tumor / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18095995.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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100. Shah BK, Qamruzzaman Y, Serban K, Hire E, Ying SC: First case report of locally advanced malignant nodular hidradenoma of the scrotum. Onkologie; 2010;33(12):701-3
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  • [Title] First case report of locally advanced malignant nodular hidradenoma of the scrotum.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is a malignant tumor of the eccrine glands, and most commonly involves the head, trunk, and extremities.
  • More than 2 years after surgery, the patient is without evidence of disease.
  • [MeSH-major] Acrospiroma / pathology. Genital Neoplasms, Male / pathology. Scrotum / pathology. Sweat Gland Neoplasms / pathology

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 21124043.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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