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1. van Schaik FD, Offerhaus GJ, Schipper ME, Siersema PD, Vleggaar FP, Oldenburg B: Endoscopic and pathological aspects of colitis-associated dysplasia. Nat Rev Gastroenterol Hepatol; 2009 Nov;6(11):671-8
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  • Colitis-associated dysplasia may present as a dysplasia-associated lesion or mass (DALM), which may be indistinguishable from a sporadic adenoma in non-colitic tissue, or may arise in flat mucosa of endoscopically normal appearance.

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  • (PMID = 19770847.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 72
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2. Rao SK, Schilling TF, Sequist TD: Challenges in the management of positive fecal occult blood tests. J Gen Intern Med; 2009 Mar;24(3):356-60
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  • RESULTS: Most positive FOBTs were ordered for routine colorectal cancer screening (76%), or evaluation of anemia (13%) or rectal bleeding (7%).
  • Colonoscopy was completed in 62% of cases, with one-third of these procedures identifying a colorectal adenoma (29%) or cancer (4%).

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  • (PMID = 19130147.001).
  • [ISSN] 1525-1497
  • [Journal-full-title] Journal of general internal medicine
  • [ISO-abbreviation] J Gen Intern Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2642561
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3. Waye JD, Heigh RI, Fleischer DE, Leighton JA, Gurudu S, Aldrich LB, Li J, Ramrakhiani S, Edmundowicz SA, Early DS, Jonnalagadda S, Bresalier RS, Kessler WR, Rex DK: A retrograde-viewing device improves detection of adenomas in the colon: a prospective efficacy evaluation (with videos). Gastrointest Endosc; 2010 Mar;71(3):551-6
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  • For all polyps and for adenomas, the additional detection rates for the TER were 9.7%/4.1% in the left colon (the splenic flexure to the rectum) and 16.5%/14.9% in the right colon (the cecum to the transverse colon), respectively.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Colonoscopes. Colonoscopy

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  • [Copyright] 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • [CommentIn] Gastrointest Endosc. 2010 Mar;71(3):557-9 [20189514.001]
  • [CommentIn] Gastrointest Endosc. 2011 Jan;73(1):190; author reply 193-4 [21184890.001]
  • [CommentIn] Gastrointest Endosc. 2011 Mar;73(3):637; author reply 637-8 [21353861.001]
  • (PMID = 20018280.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00657371
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Cimitan A, Burza A, Basile U, Saputo S, Mingazzini P, Stipa F: [Local excision of giant rectal polypoid neoplasms]. Chir Ital; 2008 May-Jun;60(3):345-53
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  • [Title] [Local excision of giant rectal polypoid neoplasms].
  • [Transliterated title] Escissione locale delle neoplasie polipoidi giganti del retto.
  • Local excision is the best therapeutic option for giant adenomas of the rectum.
  • Parks technique for lower rectal lesions and the T.E.M. technique for lesions localised in the middle and upper rectum offer exceptionally good exposure, allowing radical excision in the case of early low-risk T1 adenocarcinomas (well or moderately differentiated [G1/2] without lymphovascular invasion [L0]).
  • From July 1987 to March 2006, 224 patients were treated by local excision for rectal lesions in our department.
  • In 3 patients with a preoperative diagnosis of severe dysplasia (Tis) final pathology showed adenoma and for this reason they were included in our study group.
  • In 26 patients (51%) the diagnosis was adenoma.
  • Giant sessile polypoid lesions localized in the middle and upper rectum are best treated with T.E.M., while Parks technique is a good option in lower rectal tumours.
  • [MeSH-major] Rectal Neoplasms / surgery

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  • (PMID = 18709772.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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5. Lee EJ, Choi C, Park CK, Maeng L, Lee J, Lee A, Kim KM: Tracing origin of serrated adenomas with BRAF and KRAS mutations. Virchows Arch; 2005 Sep;447(3):597-602
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  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 15991007.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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6. Church J: Adenoma detection rate and the quality of colonoscopy: the sword has two edges. Dis Colon Rectum; 2008 May;51(5):520-3
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  • [Title] Adenoma detection rate and the quality of colonoscopy: the sword has two edges.
  • Few publications have considered the full implications of pushing the adenoma detection rate as a prime quality indicator.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy / standards. Colorectal Neoplasms / diagnosis. Quality Indicators, Health Care

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  • (PMID = 18322755.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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7. Mila R, Grille S, Laurini M, Lapiedra D, Bagattini JC: [McKittrick- Wheelock syndrome: report of one case]. Rev Med Chil; 2008 Jul;136(7):900-4
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  • [Transliterated title] Síndrome de McKittrick-Wheelock: Una causa infrecuente de shock hipovolémico.
  • On rectal palpation a large tumor located 5 cm above the anus was palpated.
  • Colonoscopy confirmed the presence of a villous adenoma that was excised surgically.
  • In this patient, the fluid and electrolyte hypersecretion of the rectal villous adenoma provoked a depletion syndrome with serious hydroelectrolytic alterations, acute renal failure and hypovolemic shock.
  • [MeSH-major] Adenoma, Villous / complications. Colonic Neoplasms / complications. Water-Electrolyte Imbalance / etiology
  • [MeSH-minor] Diarrhea / etiology. Female. Humans. Middle Aged. Rectum / surgery. Syndrome

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  • (PMID = 18949168.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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8. Greco SA, Chia J, Inglis KJ, Cozzi SJ, Ramsnes I, Buttenshaw RL, Spring KJ, Boyle GM, Worthley DL, Leggett BA, Whitehall VL: Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation. BMC Cancer; 2010;10:494
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  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. DNA Methylation. Gene Expression Regulation, Neoplastic. Genes, Tumor Suppressor. Thrombospondins / genetics
  • [MeSH-minor] Age Factors. Cohort Studies. Colon / metabolism. Colon / pathology. Colony-Forming Units Assay. CpG Islands. DNA / genetics. Humans. Immunoenzyme Techniques. Middle Aged. Phenotype. Polymerase Chain Reaction. Prognosis. Promoter Regions, Genetic / genetics. Rectum / metabolism. Rectum / pathology

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  • (PMID = 20846368.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Thrombospondins; 0 / thrombospondin 4; 9007-49-2 / DNA
  • [Other-IDs] NLM/ PMC2946314
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9. Lin GL, Meng WC, Lau PY, Qiu HZ, Yip AW: Local resection for early rectal tumours: Comparative study of transanal endoscopic microsurgery (TEM) versus posterior trans-sphincteric approach (Mason's operation). Asian J Surg; 2006 Oct;29(4):227-32
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  • [Title] Local resection for early rectal tumours: Comparative study of transanal endoscopic microsurgery (TEM) versus posterior trans-sphincteric approach (Mason's operation).
  • OBJECTIVE: To compare local resection of early rectal tumours by transanal endoscopic microsurgery (TEM) and the conventional posterior trans-sphincteric approach (Mason's operation).
  • METHODS: The study group comprised 31 consecutive patients with early rectal tumours (18 villous adenomas, 13 adenocarcinomas) who underwent TEM in Kwong Wah Hospital, Hong Kong.
  • The control group consisted of 51 patients with early rectal tumours (27 villous adenomas, 24 adenocarcinomas) who underwent Mason's operation in Peking Union Medical College Hospital, Beijing.
  • CONCLUSION: TEM is as effective as the conventional posterior trans-sphincteric approach (Mason's operation) for local curative resection of early rectal tumours.

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  • (PMID = 17098653.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
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10. Jasiński A, Szyca R, Tomaszewski S, Leksowski K: [Long-term results of rectal tumors treatment by transanal endoscopic microsurgery (TEM)]. Pol Merkur Lekarski; 2007 May;22(131):379-80
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  • [Title] [Long-term results of rectal tumors treatment by transanal endoscopic microsurgery (TEM)].
  • Transanal endoscopic microsurgery (TEM) is a minimally invasive technique for excision of selected benign and malignant rectal neoplasmas.
  • The aim of this study was to assess the long-term results after benign and malignant rectal lesions excision using TEM.
  • Two patients have had stricture of the rectum.
  • CONCLUSION: TEM is a safe, effective treatment for selected cases of benign lesions and some cases of early stage rectal cancer.
  • [MeSH-major] Adenoma / surgery. Anal Canal / surgery. Endoscopy, Gastrointestinal. Liver Neoplasms / secondary. Microsurgery. Rectal Neoplasms / surgery. Rectum / surgery

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  • (PMID = 17679373.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Poland
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11. Will OC, Hansmann A, Phillips RK, Palazzo FF, Meeran K, Marshall M, Clark SK: Adrenal incidentaloma in familial adenomatous polyposis: a long-term follow-up study and schema for management. Dis Colon Rectum; 2009 Sep;52(9):1637-44
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  • RESULTS: Overall, 3 of 30 patients underwent adrenalectomy; one patient had pheochromocytoma and another had an adenoma of borderline malignancy.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / therapy. Adenomatous Polyposis Coli / pathology. Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / therapy. Incidental Findings


12. Schäfer H, Baldus SE, Hölscher AH: Giant adenomas of the rectum: complete resection by transanal endoscopic microsurgery (TEM). Int J Colorectal Dis; 2006 Sep;21(6):533-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant adenomas of the rectum: complete resection by transanal endoscopic microsurgery (TEM).
  • BACKGROUND: Large sessile adenomas of the rectum, with a diameter greater than 5 cm, have a high risk to undergo malignant transformation.
  • Transanal endoscopic microsurgery (TEM) offers an alternative operation method to low-anterior rectum resection in this potentially benign tumor situation.
  • PATIENTS: We retrospectively investigated patients with giant adenomas of the rectum (>5 cm) who were treated by TEM over the last 10 years.
  • The residual adenoma status was 18% (n=6), especially in patients with tumors sizes more than 30 cm2.
  • In case of adenoma recurrence (n=4, 12%), a conventional transanal excision (Parks) was applicable, as these tumors were mostly located within the suture-line region of the lower rectum.
  • In case of advanced tumors (1xpT2, 1xpT3), anterior rectum resection was carried out, whereas for the early tumors (2xpT1 low risk, 1x1 pTis), no further therapy was added.
  • CONCLUSION: TEM is an alternative method for the resection of large benign rectal tumors located in the mid- and upper third of the rectum.
  • [MeSH-major] Adenoma / surgery. Colonoscopy / methods. Microsurgery. Rectal Neoplasms / surgery

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  • (PMID = 16133003.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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13. He JJ: [Meta analysis of 2025 cases with multiple primary colorectal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 May;9(3):225-9
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  • 30.9% of the lesions were located in the rectum, 19.9% in the sigmoid, 9.0% in the descending colon, 5.2% the in splenic flexure, 9.1% in the transverse colon, 6.1% in the hepatic flexure, 11.8% in the ascending colon,and 8.1% in the caecum.
  • 37.6% of the cases were complicated with extra- intestinal lesions,and 43.7% adenoma or polyps.
  • Histological type was the same in 60.6% of the cases,and adenocarcinoma accounted for 89.2% and cancerization of adenoma 8.4%.

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  • (PMID = 16721683.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Meta-Analysis
  • [Publication-country] China
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14. East JE, Suzuki N, Stavrinidis M, Guenther T, Thomas HJ, Saunders BP: Narrow band imaging for colonoscopic surveillance in hereditary non-polyposis colorectal cancer. Gut; 2008 Jan;57(1):65-70
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  • RESULTS: At least one adenoma in the proximal colon was detected during the initial white light pass in 17/62 (27%).
  • 26/62 (42%) patients had at least one adenoma detected after both white light and NBI; absolute difference 15% (95% CI 4-25%), p = 0.004 versus white light alone.
  • Including white light examination of the sigmoid and rectum, overall 28/62 (45%) patients had at least one adenoma detected.
  • CONCLUSIONS: Use of NBI in the proximal colon for patients undergoing HNPCC surveillance appears to improve adenoma detection, particularly those with a flat morphology.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy / methods. Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis


16. Burghardt J, Buess G: Transanal endoscopic microsurgery (TEM): a new technique and development during a time period of 20 years. Surg Technol Int; 2005;14:131-7
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  • The first indication for use of this new technique was excision of rectal adenomas.
  • With the development of endorectal ultrasound for staging, and because many adenomatous polyps contained early rectal cancer, the question arose as to how to deal with these patients after successful local excision.
  • Studies showed that the indication for use of the TEM-technique was extended to early, good differentiated rectal cancer-so-called, low-risk rectal cancer.
  • Many studies showed that the TEM-technique is the optimal operation to avoid complications for patients with rectal polyps and low-risk pT1 tumours of the rectum.
  • Currently, the TEM-technique is the only endoscopic technique that uses a natural opening to reach the target organ, and is a valuable surgical technique with a low complication rate for patients with adenomatous rectal tumours and early rectal cancer.
  • [MeSH-major] Adenoma / surgery. Colonoscopy / methods. Microsurgery / methods. Neoplasm Recurrence, Local / prevention & control. Rectal Neoplasms / surgery

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  • (PMID = 16525965.001).
  • [ISSN] 1090-3941
  • [Journal-full-title] Surgical technology international
  • [ISO-abbreviation] Surg Technol Int
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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17. Daniel CR, Bostick RM, Flanders WD, Long Q, Fedirko V, Sidelnikov E, Seabrook ME: TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma. Cancer Epidemiol Biomarkers Prev; 2009 Jan;18(1):65-73
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  • [Title] TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma.
  • METHODS: We measured expression of TGF-alpha in biopsies of normal-appearing colorectal mucosa using automated immunohistochemistry and quantitative image analysis in a subsample of 29 cases and 31 controls from a colonoscopy-based case-control study (n = 203) of biomarkers of risk for incident sporadic colorectal adenoma.
  • RESULTS: TGF-alpha expression in the rectum was 51% higher in cases compared with controls (P = 0.05) and statistically significantly associated with accepted risk factors for colorectal neoplasms (36% lower among nonsteroidal anti-inflammatory drug users, 49% lower among women using hormone replacement therapy, 79% higher among persons with a family history of colorectal cancer).
  • CONCLUSIONS: TGF-alpha expression in the normal-appearing rectal mucosa shows promise as an early, potentially modifiable biomarker of risk for colorectal cancer.

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  • (PMID = 19124482.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115230-02; United States / NCI NIH HHS / CA / R03 CA115230; United States / NCI NIH HHS / CA / R03 CA115230-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transforming Growth Factor alpha
  • [Other-IDs] NLM/ NIHMS253319; NLM/ PMC2995992
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18. Endreseth BH, Wibe A, Svinsås M, Mårvik R, Myrvold HE: Postoperative morbidity and recurrence after local excision of rectal adenomas and rectal cancer by transanal endoscopic microsurgery. Colorectal Dis; 2005 Mar;7(2):133-7
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  • [Title] Postoperative morbidity and recurrence after local excision of rectal adenomas and rectal cancer by transanal endoscopic microsurgery.
  • OBJECTIVE: Tumours in the middle and upper part of the rectum are not easy accessible to local excision.
  • Transanal endoscopic microsurgery (TEM) has been recommended for excision of sessile adenomas in the middle and upper part of the rectum, and for small cancers in patients not fit for major surgery.
  • The indications for TEM were rectal adenoma in 72 patients and rectal cancer in 7 patients.
  • Two (2.5%) patients had peroperative perforation in the intra-abdominal part of the rectum treated by laparotomy.
  • CONCLUSION: TEM is a safe technique well tolerated also by high-risk patients, and should be the preferred method in patients with benign tumours in the middle and upper part of the rectum, and in selected cases of early rectal cancer.
  • [MeSH-major] Adenoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 15720349.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. Schneider M, Scholtka B, Gottschalk U, Faiss S, Schatz D, Berghof-Jäger K, Steinberg P: Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1. Cancers (Basel); 2010;3(1):91-105
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  • [Title] Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1.
  • In the present study a recently conceived 4-gene marker panel covering the Wnt and Ras-Raf-MEK-MAPK signaling pathways was used to analyze 20 colorectal serrated lesions and 41 colorectal adenoma samples and to determine the percentage of each of the above-mentioned potentially precancerous lesions carrying at least one of the four above-mentioned genes in a mutated form.
  • Based on its excellent performance in detecting mutations in sporadic preneoplastic (in this study) and neoplastic lesions (in a previous study) of the human colon and rectum, this primer combination might also be suited to efficiently and non-invasively detect genetic alterations in stool DNA of patients with early colorectal cancer.

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  • (PMID = 24212608.001).
  • [ISSN] 2072-6694
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3756351
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20. Beattie GC, Paul I, Calvert CH: Endoscopic transanal resection of rectal tumours using a urological resectoscope--still has a role in selected patients. Colorectal Dis; 2005 Jan;7(1):47-50
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  • [Title] Endoscopic transanal resection of rectal tumours using a urological resectoscope--still has a role in selected patients.
  • INTRODUCTION: Transanal resection of rectal villous adenomas or adenocarcinomas can be carried out using various modalities such as operative excision, fulguration, laser coagulation or cryotherapy.
  • Transanal resection can provide effective palliation for locally advanced rectal tumours in patients unfit for abdomino-perineal excision of rectum.
  • A urological resectoscope can be safely and repeatedly used to resect advanced primary or locally recurrent rectal tumours by colorectal surgeons with urological expertise.
  • This study reports our experience of treating rectal lesions with endoscopic transanal resection (ETAR) using the urological resectoscope.
  • Histopathology revealed rectal adenoma (with varying degrees of dysplasia) in 11 (55%) patients and adenocarcinoma in 9 (45%).
  • The majority (30; 70%) of resections were carried out in patients with benign disease, with 13 (30%) in patients with rectal adenocarcinoma.
  • There were no cases of haemorrhage, rectal perforation, 'TUR syndrome' or pelvic sepsis.
  • CONCLUSIONS: Accepting that this technique provides limited histopathological information regarding extent of resection and tumour clearance, our experience demonstrates that ETAR of rectal tumours using the urological resectoscope can provide a minimally invasive, effective and safe means of treating and palliating patients with benign and malignant rectal disease.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Proctoscopy. Rectal Neoplasms / surgery. Urologic Surgical Procedures / instrumentation

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  • (PMID = 15606584.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Duncan JE, Sweeney WB, Trudel JL, Madoff RD, Mellgren AF: Colonoscopy in the elderly: low risk, low yield in asymptomatic patients. Dis Colon Rectum; 2006 May;49(5):646-51
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  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis


22. Gassler N, Herr I, Schneider A, Penzel R, Langbein L, Schirmacher P, Kopitz J: Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas. J Pathol; 2005 Nov;207(3):295-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / enzymology. Adenoma / genetics. Adenoma / metabolism. Aged. Aged, 80 and over. Cell Line, Tumor. Colon / enzymology. Colon / metabolism. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. Intestinal Mucosa / metabolism. Male. Middle Aged. Neoplasm Proteins / biosynthesis. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Rectum / enzymology. Rectum / metabolism

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  • [Copyright] Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 16110457.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 6.2.1.- / Coenzyme A Ligases; EC 6.2.1.- / acyl CoA synthetase 5
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23. Menges M, Fischinger J, Gärtner B, Georg T, Woerdehoff D, Maier M, Harloff M, Stegmaier C, Raedle J, Zeitz M: Screening colonoscopy in 40- to 50-year-old first-degree relatives of patients with colorectal cancer is efficient: a controlled multicentre study. Int J Colorectal Dis; 2006 May;21(4):301-7
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  • The adenoma prevalence in relatives of CRC patients 50-60 years of age is 17-34%; data on younger individuals are scarce.
  • Our aim was to prospectively define the adenoma prevalence in 40- to 50-year-old first-degree relatives of CRC patients compared to controls.

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  • (PMID = 16163544.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
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24. Graser A, Stieber P, Nagel D, Schäfer C, Horst D, Becker CR, Nikolaou K, Lottes A, Geisbüsch S, Kramer H, Wagner AC, Diepolder H, Schirra J, Roth HJ, Seidel D, Göke B, Reiser MF, Kolligs FT: Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population. Gut; 2009 Feb;58(2):241-8
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  • [Title] Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population.
  • [MeSH-major] Adenoma / diagnosis. Colorectal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Colon / pathology. Colonic Polyps / diagnosis. Colonography, Computed Tomographic / methods. Colonoscopy / methods. Feces / chemistry. Female. Hemoglobins / analysis. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Occult Blood. Prospective Studies. Rectum / pathology. Sample Size. Sensitivity and Specificity. Sigmoidoscopy / methods. Video Recording

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  • [CommentIn] Gut. 2010 Jan;59(1):137 [20007962.001]
  • (PMID = 18852257.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hemoglobins
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25. Yalcinkaya U, Ozturk E, Ozgur T, Yerci O, Yilmazlar T: P53 expression in synchronous colorectal cancer. Saudi Med J; 2008 Jun;29(6):826-31
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  • OBJECTIVE: We reviewed cases of primary colorectal adenocarcinoma to document synchronous colon and rectum adenocarcinoma (SCRC).
  • Tumor site, depth of invasion, coexistence of adenoma, distance between these multiple primary tumors, degree of p53 expression, and p53 expression pattern indicating polyclonal or monoclonal origins were noted in order to establish a possible effect on prognosis.
  • RESULTS: There were 28 cases with SCRC of colon and rectum.
  • CONCLUSION: Synchronous colon and rectum adenocarcinoma is not rare.
  • [MeSH-major] Adenocarcinoma / chemistry. Colonic Neoplasms / chemistry. Neoplasms, Multiple Primary / chemistry. Rectal Neoplasms / chemistry. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 18521459.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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26. Graham RP, Williams NP, West KA: Primary epithelial tumours of the appendix in a black population: a review of cases. World J Gastroenterol; 2009 Mar 28;15(12):1472-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenoma / epidemiology. Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / epidemiology. Carcinoid Tumor / pathology. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. West Indies / epidemiology. Young Adult

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27. Jang KS, Song YS, Jang SH, Min KW, Na W, Jang SM, Jun YJ, Lee KH, Choi D, Paik SS: Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma. Histopathology; 2010 Jan;56(2):229-39
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  • Loss of PTEN expression was related to defective mismatch repair protein expression and colonic localization rather than rectal localization.
  • CONCLUSIONS: Nuclear PTEN expression gradually decrease during the normal-adenoma-adenocarcinoma-metastasis sequence, which suggests an important role for PTEN in carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenomatous Polyps / metabolism. Cell Nucleus / metabolism. Colon / metabolism. Colorectal Neoplasms / metabolism. Intestinal Mucosa / metabolism. Lymph Nodes / metabolism. PTEN Phosphohydrolase / metabolism. Rectum / metabolism

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  • (PMID = 20102402.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; EC 3.1.3.67 / PTEN Phosphohydrolase
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28. Hsiung PL, Hardy J, Friedland S, Soetikno R, Du CB, Wu AP, Sahbaie P, Crawford JM, Lowe AW, Contag CH, Wang TD: Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy. Nat Med; 2008 Apr;14(4):454-8
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  • [Title] Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy.
  • A combination of targeted probes and new imaging technologies provides a powerful set of tools with the potential to improve the early detection of cancer.
  • To develop a probe for detecting colon cancer, we screened phage display peptide libraries against fresh human colonic adenomas for high-affinity ligands with preferential binding to premalignant tissue.
  • We identified a specific heptapeptide sequence, VRPMPLQ, which we synthesized, conjugated with fluorescein and tested in patients undergoing colonoscopy.
  • We imaged topically administered peptide using a fluorescence confocal microendoscope delivered through the instrument channel of a standard colonoscope.
  • In vivo images were acquired at 12 frames per second with 50-microm working distance and 2.5-microm (transverse) and 20-microm (axial) resolution.
  • The fluorescein-conjugated peptide bound more strongly to dysplastic colonocytes than to adjacent normal cells with 81% sensitivity and 82% specificity.
  • This methodology represents a promising diagnostic imaging approach for the early detection of colorectal cancer and potentially of other epithelial malignancies.

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  • (PMID = 18345013.001).
  • [ISSN] 1546-170X
  • [Journal-full-title] Nature medicine
  • [ISO-abbreviation] Nat. Med.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK56339; United States / NIDDK NIH HHS / DK / K08 DK067618; United States / NIDDK NIH HHS / DK / K08 DK067618-06; United States / NCI NIH HHS / CA / U54 CA105296; United States / NCI NIH HHS / CA / U54 CA136429; United States / NIDDK NIH HHS / DK / R03 DK075603-03; United States / NIDDK NIH HHS / DK / P30 DK056339; United States / NCI NIH HHS / CA / U54 CA136429-01; United States / NIDDK NIH HHS / DK / R03 DK075603
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fluorescent Dyes; 0 / Oligopeptides; 0 / Peptide Library; TPY09G7XIR / Fluorescein
  • [Other-IDs] NLM/ NIHMS366716; NLM/ PMC3324975
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29. Bruce WR, Cirocco M, Giacca A, Kim YI, Marcon N, Minkin S: A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation. Br J Cancer; 2005 Sep 19;93(6):639-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / complications. Adult. Aged. Aged, 80 and over. Blood Glucose / metabolism. C-Reactive Protein / metabolism. Calcium Carbonate / administration & dosage. Dietary Supplements. Female. Fish Oils / administration & dosage. Folic Acid / administration & dosage. Humans. Male. Middle Aged. Pilot Projects. Risk Factors. Thiamine / metabolism. Treatment Outcome. Vitamin B 12 Deficiency / complications. Vitamin B 12 Deficiency / therapy

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  • (PMID = 16136044.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Blood Glucose; 0 / Fish Oils; 9007-41-4 / C-Reactive Protein; 935E97BOY8 / Folic Acid; H0G9379FGK / Calcium Carbonate; X66NSO3N35 / Thiamine
  • [Other-IDs] NLM/ PMC2361622
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30. Fujimori S, Kishida T, Kobayashi T, Sekita Y, Seo T, Nagata K, Tatsuguchi A, Gudis K, Yokoi K, Tanaka N, Yamashita K, Tajiri T, Ohaki Y, Sakamoto C: Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women. J Gastroenterol; 2005 Sep;40(9):887-93
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  • [Title] Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women.
  • The purpose of this study was to assess the association between H. pylori infection and the risk of colorectal adenoma and adenocarcinoma, and to evaluate any differences on the basis of sex.
  • The odds ratios (ORs) for H. pylori-positive patients with colorectal adenoma and adenocarcinoma, and for tumor patients with either adenoma or adenocarcinoma were calculated.
  • RESULTS: Among the H. pylori-negative patients, there were 52 patients without tumor, 63 with adenoma, 27 with adenocarcinoma, and 90 with tumor.
  • Pooling all subjects, those infected with H. pylori had a significantly increased OR for adenoma, adenocarcinoma, or tumor, compared to H. pylori-free patients (OR, 1.60, 1.80, and 1.66, respectively).
  • CONCLUSIONS: The results therefore suggest that, in patients aged 40-80 years, H. pylori infection increased the risk of colorectal adenoma and adenocarcinoma, with significantly higher risks for female patients.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Colorectal Neoplasms / etiology. Helicobacter Infections / complications

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  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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31. Lai HC, Chan CY, Peng CY, Chen CB, Huang WH: Pyogenic liver abscess associated with large colonic tubulovillous adenoma. World J Gastroenterol; 2006 Feb 14;12(6):990-2
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  • [Title] Pyogenic liver abscess associated with large colonic tubulovillous adenoma.
  • Rarely, liver abscess has been reported as the presenting manifestation of colonic tubulovillous adenoma.
  • Colonoscopy revealed large polypoid tumors with pathological findings of tubulovillous adenoma in both cases.
  • [MeSH-major] Adenoma / pathology. Adenoma / radiography. Colonic Neoplasms / pathology. Colonic Neoplasms / radiography. Liver Abscess, Pyogenic / pathology. Liver Abscess, Pyogenic / radiography

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  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
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32. Barry EL, Baron JA, Grau MV, Wallace K, Haile RW: K-ras mutations in incident sporadic colorectal adenomas. Cancer; 2006 Mar 1;106(5):1036-40
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  • These mutations were more common in larger adenomas (risk ratio [RR], 12.7 for tumors that measured > 0.5 cm vs. < or = 0.5 cm; 95% CI, 2.7-59.7), in adenomas with more advanced histology (RR, 20.6 for tubulovillous/villous vs. tubular; 95% CI, 4.4-96.0), and in adenomas that were located in the rectum compared with the colon (RR, 8.4; 95% CI, 2.3-30.5).
  • The results provided evidence for a very low rate of K-ras mutation among these small, early adenomas and strong support for a role of K-ras mutations in adenoma progression.

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  • (PMID = 16456810.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA046927; United States / NCI NIH HHS / CA / CA-046927
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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33. Schulte T, Kahlke V: [Mass of the pelvis minor--the coloproctological point of view]. Ther Umsch; 2007 Jul;64(7):389-94
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  • It contains the pelvic organs like the inner genital organs of women, the urinary bladder the rectum and parts of the anus.
  • The rectum is the origin of benign and malign tumors.
  • Most frequently you find under these tumors the benign adenoma and hamartoma and the malign like the rectal and anal cancer.
  • [MeSH-major] Anus Neoplasms. Pelvic Neoplasms. Rectal Neoplasms
  • [MeSH-minor] Adult. Colonoscopy. Combined Modality Therapy. Diagnosis, Differential. Endosonography. Humans. Middle Aged. Neoplasm Staging. Postoperative Care. Proctoscopy. Rectum / pathology. Tomography, X-Ray Computed

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  • (PMID = 17948756.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Switzerland
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34. Beggs AD, Hodgson SV: The genomics of colorectal cancer: state of the art. Curr Genomics; 2008 Mar;9(1):1-10
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  • The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.

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  • [ISSN] 1389-2029
  • [Journal-full-title] Current genomics
  • [ISO-abbreviation] Curr. Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC2674304
  • [Keywords] NOTNLM ; Colorectal / cancer / epigenomics. / genomics
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35. Turovskaya O, Foell D, Sinha P, Vogl T, Newlin R, Nayak J, Nguyen M, Olsson A, Nawroth PP, Bierhaus A, Varki N, Kronenberg M, Freeze HH, Srikrishna G: RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis; 2008 Oct;29(10):2035-43
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  • In human colon tumor tissues and in a mouse model of CAC, we found that myeloid progenitors expressing S100A8 and S100A9 infiltrate regions of dysplasia and adenoma. mAbGB3.1 administration markedly reduces chronic inflammation and tumorigenesis in the mouse model of CAC and RAGE-deficient mice are resistant to the onset of CAC.

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  • (PMID = 18689872.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01-CA92608
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Advanced Glycosylation End Product-Specific Receptor; 0 / Antigens, CD11b; 0 / Calgranulin A; 0 / Calgranulin B; 0 / ITGAM protein, human; 0 / NF-kappa B; 0 / Polysaccharides; 0 / Receptors, Immunologic
  • [Other-IDs] NLM/ PMC2556970
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36. Kanczuga-Koda L, Sulkowski S, Koda M, Sulkowska M: Alterations in connexin26 expression during colorectal carcinogenesis. Oncology; 2005;68(2-3):217-22
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  • METHODS: Tissue samples (152 from colorectal cancer and 75 from adenoma) were investigated by immunohistochemistry, using the antibody for Cx26.
  • Moreover, Cx26 was assessed in normal epithelium of the colon and rectum, adjacent to colorectal cancer.

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16015037.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Connexins; 127120-53-0 / connexin 26
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37. Cha JM, Lee JI, Joo KR, Jung SW, Shin HP: A prospective randomized study on computed virtual chromoendoscopy versus conventional colonoscopy for the detection of small colorectal adenomas. Dig Dis Sci; 2010 Aug;55(8):2357-64
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  • [MeSH-major] Adenoma / diagnosis. Colonoscopy / methods. Colorectal Neoplasms / diagnosis. Endoscopy, Gastrointestinal / methods

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  • (PMID = 19834809.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Suárez Cueva Y, Campos Nizama J: [Evaluation of the colonic endoscopic polypectomy in patients of the National Carlos Alberto Seguín Escobedo Hospital ESSALUD of Arequipa (1999-2004)]. Rev Gastroenterol Peru; 2006 Jan-Mar;26(1):34-43
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  • [Transliterated title] Evaluación de la polipectomía endoscópica colónica en pacientes del Hospital Nacional Carlos Alberto Seguín Escobedo ESSALUD de Arequipa (1999-2004).
  • The polyps endoscopic characteristics found that the sessile were the more frequent and were located in rectum--sigmoid zone.
  • The histopathology type of the polyps was adenoma, frequently with some grade of dysplasia.

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  • (PMID = 16622486.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
  • [Chemical-registry-number] 0 / Angiogenic Proteins
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39. Edwards CM, Chapman SJ: Biomechanical modelling of colorectal crypt budding and fission. Bull Math Biol; 2007 Aug;69(6):1927-42
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  • [MeSH-major] Colon / anatomy & histology. Colon / physiology. Models, Biological. Rectum / anatomy & histology. Rectum / physiology
  • [MeSH-minor] Adenoma / etiology. Adenoma / pathology. Adenoma / physiopathology. Biomechanical Phenomena. Carcinoma / etiology. Carcinoma / pathology. Carcinoma / physiopathology. Colorectal Neoplasms / etiology. Colorectal Neoplasms / pathology. Colorectal Neoplasms / physiopathology. Elasticity. Humans. Intestinal Polyps / etiology. Intestinal Polyps / pathology. Intestinal Polyps / physiopathology. Mathematics. Mutation. Wnt Proteins / genetics

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  • (PMID = 17443390.001).
  • [ISSN] 0092-8240
  • [Journal-full-title] Bulletin of mathematical biology
  • [ISO-abbreviation] Bull. Math. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Wnt Proteins
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40. Kato S, Fu KI, Sano Y, Fujii T, Saito Y, Matsuda T, Koba I, Yoshida S, Fujimori T: Magnifying colonoscopy as a non-biopsy technique for differential diagnosis of non-neoplastic and neoplastic lesions. World J Gastroenterol; 2006 Mar 7;12(9):1416-20
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  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Diagnosis, Differential. Female. Hamartoma / diagnosis. Hamartoma / pathology. Humans. Hyperplasia / diagnosis. Male. Middle Aged. Prospective Studies. Sensitivity and Specificity

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  • (PMID = 16552812.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4124321
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41. Schäfer HH, Vivaldi C, Hölscher AH: [Local excision with transanal endoscopic microsurgery (TEM) after endoscopic R1/R2-polypectomy of pT1 "low-risk" carcinomas of the rectum]. Z Gastroenterol; 2006 Aug;44(8):647-50
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  • [Title] [Local excision with transanal endoscopic microsurgery (TEM) after endoscopic R1/R2-polypectomy of pT1 "low-risk" carcinomas of the rectum].
  • The transanal endoscopic microsurgery (TEM) is an adequate method for the local full-thickness excision of large rectum polyps and pT1 "low-risk" rectal carcinomas.
  • We studied prospectively the relevance of this surgical technique concerning complete tumour excision after R1/R2-polypectomy of malignant rectal polyps.
  • 16 patients with pT1 "low-risk" rectal carcinoma and macroscopic (R2) or microscopic (R1) incomplete endoscopic polypectomy were locally resected by TEM.
  • In the remaining four cases (25 %), one adenoma with high-grade atypia, two pT1 "low-risk" carcinomas and one tumour infiltration in the mesorectal fat were diagnosed.
  • Transanal endoscopic microsurgery is a suitable method for the treatment of pT1 "low-risk" rectal carcinomas after incomplete endoscopic polypectomy.
  • [MeSH-major] Intestinal Polyps / surgery. Microsurgery / methods. Neoplasm Recurrence, Local / prevention & control. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 16902894.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
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42. Wang W, Zhou ZW, Wan DS, Lu ZH, Chen G, Pan ZZ, Li LR, Wu XJ, Ding PR: [Clinical analyses of 70 cases of multiple primary colorectal carcinoma]. Ai Zheng; 2008 May;27(5):505-9
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  • Thirty-three patients had colorectal carcinoma accompanying with adenoma and multiple polyps.
  • The patients accompanying with adenoma and multiple polyps should be followed up intensively.
  • [MeSH-major] Carcinoma, Ductal / surgery. Colectomy / methods. Colonic Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / surgery. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / pathology. Adenocarcinoma, Papillary / surgery. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Rectum / surgery. Retrospective Studies. Survival Rate

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  • (PMID = 18479600.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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43. Sequist TD, Zaslavsky AM, Marshall R, Fletcher RH, Ayanian JZ: Patient and physician reminders to promote colorectal cancer screening: a randomized controlled trial. Arch Intern Med; 2009 Feb 23;169(4):364-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / prevention & control. Adult. Aged. Aged, 80 and over. Colonoscopy. Early Detection of Cancer. Female. Humans. Internet. Male. Middle Aged. Occult Blood. Office Visits / statistics & numerical data. Pamphlets. Patient Education as Topic / methods. Postal Service. Sigmoidoscopy

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  • (PMID = 19237720.001).
  • [ISSN] 1538-3679
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00355004
  • [Grant] United States / NCI NIH HHS / CA / R01 CA112367; United States / NCI NIH HHS / CA / R01 CA112367-04; United States / NCI NIH HHS / CA / R01 CA 112367
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS73290; NLM/ PMC2683730
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44. Qiu HZ, Lin GL, Zhou JL, Xiao Y, Wu B: [Transanal endoscopic microsurgery for the treatment of localized rectal neoplasms]. Zhonghua Wai Ke Za Zhi; 2009 Jul 1;47(13):981-3
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  • [Title] [Transanal endoscopic microsurgery for the treatment of localized rectal neoplasms].
  • OBJECTIVE: To investigate the therapeutic effect of transanal endoscopic microsurgery (TEM) for localized rectal neoplasms.
  • METHODS: Seventy-five patients with localized rectal neoplasms were treated by using TEM between April 2006 and December 2008.
  • RESULTS: The mean diameter of the rectal lesions was (1.6 +/- 0.8) cm (range, 0.5-5.0 cm).
  • Locations of the lesions at the rectal wall: 25 located at the anterior wall, 24 at the posterior wall, 14 at the left wall and 12 at the right wall.
  • The postoperative pathological examination identified 28 cases of rectal adenoma, 25 rectal adenocarcinoma or carcinomatous changes of adenoma (14 cases with phase Tis tumor, 5 cases T1 and 6 cases T2), 7 rectal carcinoid and 15 cases of inflammatory polyps or others.
  • CONCLUSION: Being a kind of minimally invasive surgery, TEM shows advantages of decreased blood loss, better therapeutic effect and faster recovery, and it is a better choice of procedure for local excision for rectal neoplasms.
  • [MeSH-major] Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 19957806.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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45. Khder SA, Trifan A, Danciu M, Stanciu C: [Colorectal polyps: clinical, endoscopic, and histopathologic features]. Rev Med Chir Soc Med Nat Iasi; 2008 Jan-Mar;112(1):59-65
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  • Three-quarters of polyps were distal (rectum, sigmoid, and descendent colon) in location, and most of them (75.8%) had a size less than 10 mm.
  • Most of polyps were identified in patients older than 50 years, predominantly men, located in distal colon, had a tubular adenoma histological structure, and frequently associated with hemorrhoids and diverticular disease.
  • [MeSH-major] Colon / pathology. Colonic Polyps / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Intestinal Polyps / diagnosis. Rectum / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Romania / epidemiology. Treatment Outcome

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  • (PMID = 18677904.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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46. Hou L, Chatterjee N, Huang WY, Baccarelli A, Yadavalli S, Yeager M, Bresalier RS, Chanock SJ, Caporaso NE, Ji BT, Weissfeld JL, Hayes RB: CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma. Carcinogenesis; 2005 Jun;26(6):1122-8
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  • [Title] CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma.
  • Cigarette use is a risk factor for colorectal adenoma, a known precursor of colorectal cancer.
  • We investigated the association of cigarette smoking with risk for advanced colorectal adenoma in relation to the CYP1A1 Val(462) and NQO1 Ser(187) polymorphic variants.
  • Subjects were 725 non-Hispanic Caucasian cases with advanced colorectal adenoma of the distal colon (descending colon, sigmoid and rectum) and 729 gender- and ethnicity-matched controls, randomly selected from participants in the prostate, lung, colorectal and ovarian cancer screening trial.
  • Subjects carrying either CYP1A1 Val(462) or NQO1 Ser(187) alleles were weakly associated with risk of colorectal adenoma; however, subjects carrying both CYP1A1 Val(462) and NQO1 Ser(187) alleles showed increased risks (OR = 2.2, 95% CI = 1.1-4.5), particularly among recent (including current) (OR = 17.4, 95% CI = 3.8-79.8, P for interaction = 0.02) and heavy cigarette smokers (>20 cigarettes/day) (OR = 21.1, 95% CI = 3.9-114.4, P for interaction = 0.03) compared with non-smokers who did not carry either of these variants.
  • In analysis of adenoma subtypes, the combined gene variants were most strongly associated with the presence of multiple adenoma (P = 0.002).
  • In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Cytochrome P-450 CYP1A1 / genetics. NAD(P)H Dehydrogenase (Quinone) / genetics. Polymorphism, Genetic. Smoking / adverse effects

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  • (PMID = 15731166.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human
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47. Sidelnikov E, Bostick RM, Flanders WD, Long Q, Fedirko V, Shaukat A, Daniel CR, Rutherford RE: Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients. Cancer Epidemiol Biomarkers Prev; 2010 Apr;19(4):1022-32
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  • [Title] Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients.
  • Ninety-two men and women with at least one pathology-confirmed colorectal adenoma were treated with 2.0 g/d calcium or 800 IU/d vitamin D(3), alone or in combination, versus placebo over 6 months.
  • Colorectal crypt overall expression and distribution of MSH2 and MLH1 proteins in biopsies of normal-appearing rectal mucosa were detected by automated immunohistochemistry and quantified by image analysis.
  • These findings suggest that higher calcium and vitamin D intakes may result in increased DNA MMR system activity in the normal colorectal mucosa of sporadic adenoma patients and that the strongest effects may be vitamin D related and in the differentiation zone of the colorectal crypt.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / drug effects. Adenoma / prevention & control. Antineoplastic Agents / therapeutic use. Calcium Carbonate / therapeutic use. Colorectal Neoplasms / prevention & control. MutS Homolog 2 Protein / drug effects. Nuclear Proteins / drug effects. Vitamin D / therapeutic use
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Double-Blind Method. Female. Humans. Image Interpretation, Computer-Assisted. Immunohistochemistry. Intestinal Mucosa / drug effects. Intestinal Mucosa / metabolism. Male. Middle Aged. Pilot Projects. Rectum / drug effects. Rectum / metabolism

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  • (PMID = 20332274.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA104637; United States / NCI NIH HHS / CA / R01 CA104637
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 1406-16-2 / Vitamin D; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein; H0G9379FGK / Calcium Carbonate
  • [Other-IDs] NLM/ NIHMS422714; NLM/ PMC3513334
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48. Katsinelos P, Basdanis G, Chatzimavroudis G, Karagiannoulou G, Katsinelos T, Paroutoglou G, Papaziogas B, Paraskevas G: Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. World J Gastroenterol; 2006 Aug 14;12(30):4927-9
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  • [Title] Pancreatitis complicating mucin-hypersecreting common bile duct adenoma.
  • He underwent a modified Whipple operation and histological examination of the surgical specimen showed villous adenoma with rich secretion of mucus.
  • [MeSH-major] Adenoma, Bile Duct / complications. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Mucins / secretion. Pancreatitis / etiology

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49. Hakeem A, Badrinath K: "Scoping-around" a sigmoidorectal intussusception: a pitfall of flexible sigmoidoscopy. BMJ Case Rep; 2009;2009
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50. Schiessel R, Novi G, Holzer B, Rosen HR, Renner K, Hölbling N, Feil W, Urban M: Technique and long-term results of intersphincteric resection for low rectal cancer. Dis Colon Rectum; 2005 Oct;48(10):1858-65; discussion 1865-7
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  • [Title] Technique and long-term results of intersphincteric resection for low rectal cancer.
  • PURPOSE: Intersphincteric resection of low rectal tumors is a surgical technique extending rectal resection into the intersphincteric space.
  • RESULTS: One hundred seventeen patients had rectal cancers, two had dysplastic villous adenomas, and two had carcinoid tumors.
  • CONCLUSIONS: Intersphincteric resection is a valuable procedure for sphincter-saving rectal surgery.
  • An important prerequisite is a careful preoperative evaluation of local tumor spread with rectal magnetic resonance imaging excluding infiltration of the external sphincter.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Rectal Neoplasms / surgery

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  • (PMID = 16086223.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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51. Tanaka T: Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog; 2009;8:5
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  • The focus is on human and murine colorectal carcinogenesis and the histogenesis of this malignant disorder.
  • The earliest phases of colorectal oncogenesis occur in the normal mucosa, with a disorder of cell replication.
  • The large majority of colorectal malignancies develop from an adenomatous polyp (adenoma).
  • Carcinomas usually originate from pre-existing adenomas, but this does not imply that all polyps undergo malignant changes and does not exclude de novo oncogenesis.

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  • [ISSN] 1477-3163
  • [Journal-full-title] Journal of carcinogenesis
  • [ISO-abbreviation] J Carcinog
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2678864
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52. Liao F, Dong W, Fan L: Apoptosis of human colorectal carcinoma cells is induced by blocking hepatoma-derived growth factor. Med Oncol; 2010 Dec;27(4):1219-26
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  • [MeSH-minor] Adenoma / genetics. Adenoma / metabolism. Adenoma / pathology. Blotting, Western. Cell Proliferation. Colitis / genetics. Colitis / metabolism. Colitis / pathology. Colon / metabolism. Colon / pathology. Cytochromes c / metabolism. Female. Flow Cytometry. Humans. Immunoenzyme Techniques. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. RNA, Messenger / genetics. Rectum / metabolism. Rectum / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19924574.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / hepatoma-derived growth factor; 9007-43-6 / Cytochromes c
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53. Ranger-Moore J, Frank D, Lance P, Alberts D, Yozwiak M, Bartels HG, Einspahr J, Bartels PH: Karyometry in rectal mucosa of patients with previous colorectal adenomas. Anal Quant Cytol Histol; 2005 Jun;27(3):134-42
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  • [Title] Karyometry in rectal mucosa of patients with previous colorectal adenomas.
  • OBJECTIVE: To determine whether karyometric measurements taken in biopsies from histologically normal-appearing rectal mucosa could serve as a biomarker for the risk of recurrence of polyps.
  • MATERIALS AND METHODS: Biopsies were taken from the rectal mucosa of cases with a prior history of colonic polyps at the baseline of the study.
  • CONCLUSION: Measurement of a sample of 100 nuclei from the rectal mucosa will suggest, for approximately 10% of cases, that a high risk for recurrence of adenomatous polyps exists and, for a slightly lower proportion, confirm that the nuclei deviate only slightly from those from individuals with no history of colonic polyps.
  • For the majority of cases with a prior history of adenoma, the nuclei in the biopsy show a notable deviation from normal, but the deviation is practically the same for cases that had a recurrence and those that did not.

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  • (PMID = 16121634.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-41108; United States / NCI NIH HHS / CA / CA-53877-09
  • [Publication-type] Clinical Trial; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cholagogues and Choleretics; 724L30Y2QR / Ursodeoxycholic Acid
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54. Lam KD, Garcia RT, Nguyen LH, Trinh H, Triadafilopoulos G, Phan JT, Nguyen K, Nguyen H, Ahmed A, Nguyen MH: Prevalence of colorectal neoplasms in Asian Americans. Dig Dis Sci; 2009 Jan;54(1):160-7
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  • [MeSH-major] Adenoma / epidemiology. Adenoma / ethnology. Asian Americans / ethnology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / ethnology

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  • (PMID = 18975084.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Harada K, Hiraoka S, Kato J, Horii J, Fujita H, Sakaguchi K, Shiratori Y: Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features. Br J Cancer; 2007 Nov 19;97(10):1425-31
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  • [MeSH-major] Adenoma / genetics. Adenoma / pathology. Chromosome Aberrations. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Proto-Oncogene Proteins p21(ras) / genetics. Signal Transduction / genetics

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  • (PMID = 17923875.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proteins; 0 / RASSF1 protein, human; 0 / RASSF2 protein, human; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ PMC2360240
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56. Wang LP, Chen J, Ning HY, Zhang XZ, Cheng J, Li L, Wang B, Dai XJ, Zhu HY, Miao JH, Wang L: [Serrated lesions of colon and their malignant potential]. Zhonghua Bing Li Xue Za Zhi; 2010 Jul;39(7):447-51
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  • One hundred and eighty-seven cases of CAD (including 160 cases of tubular adenoma and 27 cases of villous adenoma) and 36 cases of invasive adenocarcinoma were randomly selected as the controls.
  • RESULTS: Amongst the 5347 colorectal polyps studied, 258 cases (4.8%) of serrated lesions were found, which included 112 cases (43.4%, 112/258) of hyperplastic polyp, 78 cases (30.2%, 78/258) of TSA and 26 cases (10.1%, 26/258) of sessile serrated adenoma.
  • [MeSH-major] Adenoma / pathology. Cell Transformation, Neoplastic / pathology. Colorectal Neoplasms / pathology. Intestinal Polyps / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma, Villous / classification. Adenoma, Villous / metabolism. Adenoma, Villous / pathology. Colonic Polyps / metabolism. Colonic Polyps / pathology. Humans. Ki-67 Antigen / metabolism. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Rectum / pathology. Retrospective Studies. Tumor Suppressor Protein p53 / metabolism. beta Catenin / metabolism

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  • (PMID = 21055172.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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57. Helgstrand F, Iversen E, Bech K: [Transanal endoscopic microsurgery. The latest 5 years' experience in Roskilde County]. Ugeskr Laeger; 2007 May 7;169(19):1784-8
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  • [Transliterated title] Transanal endoskopisk mikrokirurgi. De seneste fem års erfaringer i Roskilde Amt.
  • The method has become more and more widespread in the treatment of benign as well as T1 rectum tumours.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Carcinoma / surgery. Microsurgery / methods. Rectal Neoplasms / surgery

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  • (PMID = 17537353.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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58. Wilhelm D, von Delius S, Weber L, Meining A, Schneider A, Friess H, Schmid RM, Frimberger E, Feussner H: Combined laparoscopic-endoscopic resections of colorectal polyps: 10-year experience and follow-up. Surg Endosc; 2009 Apr;23(4):688-93
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  • One patient, who had been converted to open resection because of incomplete laparoscopic resection of an adenoma, developed relapse of the initial adenoma and was successfully treated with repeat CLER accounting for a local recurrence rate of 0.9%.

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  • [CommentIn] Surg Endosc. 2010 Mar;24(3):732; author reply 733-4 [19688383.001]
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  • (PMID = 19169747.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
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59. Martínez García R, Gómez Abril SA, Trullenque Juan R, Martínez Mas E, Martínez Abad M: [McKittrick-Wheelock syndrome: giant secretor rectal adenoma]. Cir Esp; 2010 Feb;87(2):117-9
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  • [Title] [McKittrick-Wheelock syndrome: giant secretor rectal adenoma].
  • [Transliterated title] Síndrome de McKittrick-Wheelock: adenoma de recto gigante secretor.
  • [MeSH-major] Adenoma. Dehydration. Diarrhea. Rectal Neoplasms

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  • (PMID = 19524883.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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60. Bretagne JF, Manfredi S, Piette C, Hamonic S, Durand G, Riou F: Yield of high-grade dysplasia based on polyp size detected at colonoscopy: a series of 2295 examinations following a positive fecal occult blood test in a population-based study. Dis Colon Rectum; 2010 Mar;53(3):339-45
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  • The rates of high-grade dysplasia were calculated for 3 size categories of adenoma (diminutive, <or=5 mm; small, 6-9 mm; large, >or=10 mm).
  • Both adenoma size and a villous component within adenomas were found to be independent predictive factors for high-grade dysplasia by multivariate analysis.
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colonoscopy

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  • (PMID = 20173483.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. López-Villar I, Ayala R, Wesselink J, Morillas JD, López E, Marín JC, Díaz-Tasende J, González S, Robles L, Martínez-López J: Simplifying the detection of MUTYH mutations by high resolution melting analysis. BMC Cancer; 2010;10:408
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  • BACKGROUND: MUTYH-associated polyposis (MAP) is a disorder caused by bi-allelic germline MUTYH mutation, characterized by multiple colorectal adenomas.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Germ-Line Mutation / genetics

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  • (PMID = 20687945.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
  • [Other-IDs] NLM/ PMC2924853
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62. Groves CJ, Beveridge lG, Swain DJ, Saunders BP, Talbot IC, Nicholls RJ, Phillips RK: Prevalence and morphology of pouch and ileal adenomas in familial adenomatous polyposis. Dis Colon Rectum; 2005 Apr;48(4):816-23
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  • [MeSH-major] Adenoma / epidemiology. Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / surgery. Colonic Pouches / pathology. Ileal Neoplasms / epidemiology. Proctocolectomy, Restorative


63. Andresen PA, Heimdal K, Aaberg K, Eklo K, Ariansen S, Silye A, Fausa O, Aabakken L, Aretz S, Eide TJ, Gedde-Dahl T Jr: APC mutation spectrum of Norwegian familial adenomatous polyposis families: high ratio of novel mutations. J Cancer Res Clin Oncol; 2009 Oct;135(10):1463-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / genetics. Adenomatous Polyposis Coli / genetics. Adenomatous Polyposis Coli Protein / genetics. Colorectal Neoplasms / genetics. Germ-Line Mutation / genetics

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  • [ErratumIn] J Cancer Res Clin Oncol. 2009 Oct;135(10):1471. Eklo, Kristin [corrected to Eklo, Katrine]
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  • (PMID = 19444466.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein
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64. Rother T, Knöpfle E, Bohndorf K: [Virtual colonoscopy--and then? Relevance of small colorectal polyps]. Rofo; 2007 Feb;179(2):130-6
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  • Colorectal carcinomas are the second most frequent malignant tumors in Germany and originate predominantly from benign polyps (adenoma-carcinoma sequence).
  • [MeSH-minor] Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Colon / pathology. Female. Follow-Up Studies. Humans. Male. Mass Screening. Middle Aged. Prevalence. Rectum / pathology. Risk Factors. Sensitivity and Specificity. Time Factors

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  • (PMID = 17262241.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 42
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65. Rocha Ramírez JL, Villanueva Sáenz E, Hernández-Magro PM, Sierra Montenegro E, Soto Quirino R, Pérez Aguirre J, Blanco Lemus E: [Hereditary mixed polyposis syndrome. First report in Mexico]. Rev Gastroenterol Mex; 2005 Oct-Dec;70(4):430-3
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  • [Transliterated title] Síndrome de poliposis mixta hereditaria. Primer reporte en México.
  • At blood test with hemoglobin of 9.7 g/dL, and colonoscopy with multiple polyps within colon and rectum, upper endoscopy with a big esophageal polyp and multiple polyps in gastric and duodenal lining smaller than 1 cm.
  • Histopathologic study of the polyps report mixed pattern of polyps: (hyperplasic-adenomatous, juvenile-adenomatous, adenoma-inflammatory-hyperplasic, hyperplasic-adenomatous with a high degree dysplasia); juvenile in esophagus, and hyperplasic in stomach and duodenum.

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  • (PMID = 17058983.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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66. Neneman B, Gasiorowska A, Małecka-Panas E: The efficacy and safety of argon plasma coagulation (APC) in the management of polyp remnants in stomach and colon. Adv Med Sci; 2006;51:88-93
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  • In the case of colonic polyps the application of higher electric power should be recommended in case of large-sized lesions, located in rectum and of villous texture.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adult. Aged. Argon / therapeutic use. Colonoscopy. Endoscopy. Female. Humans. Male. Middle Aged. Prospective Studies. Treatment Outcome

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  • (PMID = 17357283.001).
  • [ISSN] 1896-1126
  • [Journal-full-title] Advances in medical sciences
  • [ISO-abbreviation] Adv Med Sci
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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67. Khamidullina GA, Kapuller LL, Sereda EN, Izbagambetov NA, Zharkov NV: [Small-cell rectal carcinoma coexisted with tubular-villous adenoma]. Arkh Patol; 2006 Sep-Oct;68(5):37-9
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  • [Title] [Small-cell rectal carcinoma coexisted with tubular-villous adenoma].
  • The paper describes a case of small-cell high-grade endocrine carcinoma of the rectum concurrent with tubular-villous adenoma in a 58 year-old woman.
  • All epithelial cells of adenoma have been ascertained to be "mixed" exoendocrine endocrinocytes (secrete mucus and contain neuroendocrine granules), contain progesterone receptors, and express CK 8, 18, and 19.
  • [MeSH-major] Adenoma, Villous / pathology. Carcinoma, Small Cell / pathology. Rectal Neoplasms / pathology

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  • (PMID = 17144530.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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68. Sasahira T, Akama Y, Fujii K, Kuniyasu H: Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas. Virchows Arch; 2005 Apr;446(4):411-5
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  • [MeSH-major] Adenoma / metabolism. Colorectal Neoplasms / metabolism. HMGB1 Protein / metabolism. Receptors, Immunologic / metabolism

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  • (PMID = 15789216.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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69. Marderstein EL, Church JM: Classic "outlet" rectal bleeding does not require full colonoscopy to exclude significant pathology. Dis Colon Rectum; 2008 Feb;51(2):202-6
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  • [Title] Classic "outlet" rectal bleeding does not require full colonoscopy to exclude significant pathology.
  • PURPOSE: Full diagnostic colonoscopy often is performed to exclude significant pathology in patients presenting with rectal bleeding.
  • The purpose of this study was to determine whether complete colonoscopy is necessary in the evaluation of patients with "outlet" rectal bleeding.
  • [MeSH-major] Colonoscopy / methods. Gastrointestinal Hemorrhage / diagnosis. Rectal Diseases / diagnosis
  • [MeSH-minor] Adenoma / complications. Adenoma / epidemiology. Adenoma / pathology. Carcinoma in Situ / complications. Carcinoma in Situ / epidemiology. Carcinoma in Situ / pathology. Colonic Neoplasms / complications. Colonic Neoplasms / epidemiology. Colonic Neoplasms / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Incidence. Middle Aged. Neoplasm Invasiveness / pathology. Retrospective Studies. Severity of Illness Index. Time Factors

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  • (PMID = 18172728.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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70. Piana S, Asioli S, Foroni M: Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. Virchows Arch; 2006 Feb;448(2):228-31
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  • [Title] Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features.
  • Rectal adenocarcinoma with diffuse oncocytic features is a very rare lesion, having been reported only once in the English literature.
  • We describe a case of oncocytic adenocarcinoma of the rectum, associated with a villous adenoma, arising on a 66-year-old man.
  • On histological examination, the adenocarcinoma was composed of neoplastic glands lined by a strongly eosinophilic, granular epithelium that deeply infiltrated the rectal wall.
  • Superficially, a villous adenoma with high-grade dysplasia was evident; adenomatous cells showed focal eosinophilic changes, consisting of a large granular cytoplasm, an oval atypical nucleus, and a prominent nucleolus.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16450120.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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71. Fukatsu H, Kato J, Nasu JI, Kawamoto H, Okada H, Yamamoto H, Sakaguchi K, Shiratori Y: Clinical characteristics of synchronous colorectal cancer are different according to tumour location. Dig Liver Dis; 2007 Jan;39(1):40-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Cecum / pathology. Colon, Ascending / pathology. Colon, Descending / pathology. Colon, Sigmoid / pathology. Colon, Transverse / pathology. Colonoscopy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Rectum / pathology

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  • (PMID = 16996329.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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72. Hüppe D, Hartmann H, Felten G, Kemen M, Tannapfel A, Gillessen A, Katalinic A: [Effectiveness of screening colonoscopy in a community-based study]. Z Gastroenterol; 2008 Feb;46(2):193-200
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  • [MeSH-major] Adenoma / prevention & control. Colonoscopy. Colorectal Neoplasms / prevention & control
  • [MeSH-minor] Aged. Aged, 80 and over. Chi-Square Distribution. Colon / pathology. Colonic Polyps / diagnosis. Colonic Polyps / surgery. Female. Follow-Up Studies. Germany. Humans. Intestinal Polyps / diagnosis. Intestinal Polyps / surgery. Kaplan-Meier Estimate. Male. Mass Screening. Middle Aged. Neoplasm Staging. Prognosis. Rectal Diseases / diagnosis. Rectal Diseases / surgery. Rectum / pathology. Retrospective Studies. Risk Assessment. Sex Factors

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  • (PMID = 18253898.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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73. Qualtrough D, Kaidi A, Chell S, Jabbour HN, Williams AC, Paraskeva C: Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells. Int J Cancer; 2007 Aug 15;121(4):734-40
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  • Our data show that PGF(2alpha) is secreted by both colorectal adenoma and carcinoma-derived cell lines at levels in excess of those detected for PGE(2).
  • We compared the relative abilities of PGF(2alpha) and PGE(2) to induce cell motility in vitro in colorectal tumor cell lines and show the first evidence of prostaglandin-induced cell motility in colorectal adenoma cell lines.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Colorectal Neoplasms / pathology. Dinoprost / physiology

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  • (PMID = 17437271.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / MC/ U127684438; United Kingdom / Medical Research Council / / U.1276.00.004.00002.01/2(61014)
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] B7IN85G1HY / Dinoprost; K7Q1JQR04M / Dinoprostone
  • [Other-IDs] NLM/ PMC2694992; NLM/ UKMS2444
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74. Byun TJ, Han DS, Ahn SB, Cho HS, Eun CS, Jeon YC, Sohn JH, Oh YH: Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer. Gut Liver; 2009 Jun;3(2):130-3
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  • This makes it difficult for endoscopists to differentiate pseudoinvasion in an adenoma from an invasive carcinoma by conventional endoscopy; instead, endoscopic ultrasonography can provide useful information for differentiating these conditions.

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  • (PMID = 20431736.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852693
  • [Keywords] NOTNLM ; Adenomatous polyps / EUS / Malignant polyp / Pseudoinvasion
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75. Ding XW, Yan JJ, An P, Lü P, Luo HS: Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines. World J Gastroenterol; 2007 Feb 28;13(8):1257-61
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  • METHODS: The expression levels of Eag1 protein were determined in 76 cancer tissues with paired non-cancerous matched tissues as well as 9 colorectal adenoma tissues by immunohistochemistry.
  • Eag1 mRNA expression was detected in 13 colorectal cancer tissues with paired non-cancerous matched tissues and 4 colorectal adenoma tissues as well as two colorectal cancer cell lines (LoVo and HT-29) by reverse transcription PCR.
  • CONCLUSION: Eag1 protein and mRNA are aberrantly expressed in colorectal cancer and occasionally expressed in colorectal adenoma.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Colorectal Neoplasms / metabolism. Ether-A-Go-Go Potassium Channels / metabolism. Gene Expression Regulation, Neoplastic
  • [MeSH-minor] Cell Line, Tumor. Colon / pathology. Female. HT29 Cells. Humans. Male. Middle Aged. Rectum / pathology


76. Jameel JK, Pillinger SH, Moncur P, Tsai HH, Duthie GS: Endoscopic mucosal resection (EMR) in the management of large colo-rectal polyps. Colorectal Dis; 2006 Jul;8(6):497-500
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  • [Title] Endoscopic mucosal resection (EMR) in the management of large colo-rectal polyps.
  • BACKGROUND: Colonoscopic polypectomy plays a major role in preventing colo-rectal cancer.
  • Most were located in the rectum and sigmoid.
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Aged. Aged, 80 and over. Colonic Polyps / surgery. Female. Humans. Intestinal Mucosa / surgery. Male. Middle Aged. Neoplasm Invasiveness. Rectal Diseases / surgery

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  • (PMID = 16784470.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Lo SH, Law WL: Laparoscopic colorectal resection for polyps not suitable for colonoscopic removal. Surg Endosc; 2005 Sep;19(9):1252-5
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  • The histopathology of colorectal polyps showed tubular (n = 12), tubulovillous (n = 13), and villous adenoma (n = 12); mixed adenomatous/hyperolastic polyps (n = 2); inflammatory polyp (n = 1); and colonic lipoma (n = 1).
  • [MeSH-major] Colonic Polyps / surgery. Laparoscopy. Rectum / surgery

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  • (PMID = 16132333.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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78. Kievit W, de Bruin JH, Adang EM, Severens JL, Kleibeuker JH, Sijmons RH, Ruers TJ, Nagengast FM, Vasen HF, van Krieken JH, Ligtenberg MJ, Hoogerbrugge N: Cost effectiveness of a new strategy to identify HNPCC patients. Gut; 2005 Jan;54(1):97-102
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  • (3) CRC and HNPCC associated cancer; or (4) adenoma before age 40 years.

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  • (PMID = 15591512.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1774368
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79. Erichsen HC, Peters U, Eck P, Welch R, Schoen RE, Yeager M, Levine M, Hayes RB, Chanock S: Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer; 2008;60(5):652-9
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  • [Title] Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma.
  • To investigate if common genetic variants in these two genes are associated with risk of colorectal tumor development, we conducted a case-control study of 656 Caucasian advanced distal colorectal adenoma cases and 665 Caucasian sigmoidoscopy-negative controls nested within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Organic Anion Transporters, Sodium-Dependent / genetics. Polymorphism, Genetic / genetics. Symporters / genetics

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  • (PMID = 18791929.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DK053211-01
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organic Anion Transporters, Sodium-Dependent; 0 / SLC23A1 protein, human; 0 / SLC23A2 protein, human; 0 / Sodium-Coupled Vitamin C Transporters; 0 / Symporters
  • [Other-IDs] NLM/ NIHMS356181; NLM/ PMC3490215
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80. Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr: Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal. World J Gastroenterol; 2009 Jul 28;15(28):3560-4
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  • [Title] Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal.
  • We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.
  • This is the case of an octogenarian man with a several year history of hemorrhoids and intermittent rectal bleeding, more recently complaining of continuous hematochezia.
  • Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma.
  • Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Anal Canal / pathology

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  • (PMID = 19630115.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2715986
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81. Ji JS, Choi KY, Lee WC, Lee BI, Park SH, Choi H, Kim BW, Chae HS, Park YM, Park YJ: Endoscopic and histopathologic predictors of recurrence of colorectal adenoma on lowering the miss rate. Korean J Intern Med; 2009 Sep;24(3):196-202
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  • [Title] Endoscopic and histopathologic predictors of recurrence of colorectal adenoma on lowering the miss rate.
  • BACKGROUND/AIMS: Although colorectal adenoma is reported to recur frequently, this may result from missing it at baseline.
  • This study evaluated the recurrence rate prospectively and clinical predictors of recurrence in colorectal adenoma after lowering the miss rate.
  • Thirty patients had a recurrent adenoma, for a recurrence rate of 23.4%.
  • Patients with three or four adenomas at baseline colonoscopy had a two-fold greater risk than those with one adenoma (hazard ratio, 2.44; 95% CI, 1.11-5.35).
  • Patients with advanced adenoma had a two-fold greater risk than those with no advanced adenoma (hazard ratio, 2.88; 95% CI, 1.40-5.95).
  • In multivariate analysis, only the presence of three or four adenomas independently predicted the recurrence of adenoma (hazard ratio, 3.19; 95% CI, 1.04-9.79).
  • CONCLUSIONS: The recurrence rate of colorectal adenoma corrected by lowering the miss rate was lower than reported rates.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 19721855.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2732778
  • [Keywords] NOTNLM ; Colorectal adenoma / Miss rate / Recurrence rate
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82. He YG, Han Y, Hua ZL, Lin MB, Zhang HB, Lv KZ, Yin L: [Analysis of 32 patients with rectal adenoma undergoing transanal endoscopic microsurgery]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Dec;13(12):910-2
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  • [Title] [Analysis of 32 patients with rectal adenoma undergoing transanal endoscopic microsurgery].
  • OBJECTIVE: To evaluate the safety and outcomes after transanal endoscopic microsurgery (TEM)for rectal adenoma.
  • METHODS: Data of 32 patients undergoing TEM for rectal adenoma between September 2006 and February 2010 in the Ruijin Hospital were reviewed.
  • RESULTS: The adenoma diameter ranged from 0.6 to 10.0(2.3±1.2) cm.
  • Complications included rectal bleeding in 1 patient, acute urinary retention in 1 patient, and pulmonary infection in 1 patient.
  • CONCLUSION: TEM is a safe and effective minimally invasive surgical technique for large rectal adenomas.
  • [MeSH-major] Adenoma / surgery. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 21186410.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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83. Rutter CM, Savarino JE: An evidence-based microsimulation model for colorectal cancer: validation and application. Cancer Epidemiol Biomarkers Prev; 2010 Aug;19(8):1992-2002
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  • METHODS: CRC-SPIN simulates individual event histories associated with colorectal cancer, based on the adenoma-carcinoma sequence: adenoma initiation and growth, development of preclinical invasive colorectal cancer, development of clinically detectable colorectal cancer, death from colorectal cancer, and death from other causes.

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  • [Copyright] (c)2010 AACR.
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  • (PMID = 20647403.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA097427-08; United States / NCI NIH HHS / CA / U01 CA097427; United States / NCI NIH HHS / CA / U01 CA097427-08; United States / NCI NIH HHS / CA / U01 CA97427
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Validation Studies
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS208492; NLM/ PMC2919657
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84. Platell C: Malignant recurrence following TEM excision of a large rectal adenoma. ANZ J Surg; 2010 Jun;80(6):468-9
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  • [Title] Malignant recurrence following TEM excision of a large rectal adenoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Adenoma / surgery. Neoplasm Recurrence, Local / surgery. Rectal Neoplasms / surgery

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  • (PMID = 20618210.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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85. Ma Y, Zhang G, Fu X, Xia O, Zhan C, Li L, Wang Z, Wu B: Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression. Oncol Rep; 2010 Jun;23(6):1569-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / metabolism. Colorectal Neoplasms / metabolism. Membrane Proteins / metabolism. Peutz-Jeghers Syndrome / metabolism. Protein-Serine-Threonine Kinases / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adolescent. Adult. Aged. Antigens, Differentiation. Blotting, Western. Colon / metabolism. Colon / pathology. Cytoplasm / metabolism. Female. Fluorescent Antibody Technique. Humans. Immunoenzyme Techniques. Male. Middle Aged. RNA, Messenger / genetics. Rectum / metabolism. Rectum / pathology. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Young Adult

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  • (PMID = 20428811.001).
  • [ISSN] 1791-2431
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Differentiation; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / beta Catenin; 0 / leu-13 antigen; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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86. Morois S, Mesrine S, Josset M, Clavel-Chapelon F, Boutron-Ruault MC: Anthropometric factors in adulthood and risk of colorectal adenomas: The French E3N-EPIC prospective cohort. Am J Epidemiol; 2010 Nov 15;172(10):1166-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Anthropometric factors have been associated with colorectal cancer and adenomas but with conflicting results in women or regarding adenoma characteristics.
  • The authors aimed to explore associations between anthropometric factors (height, weight, body mass index, waist and hip circumferences, and weight changes) and adenoma risk.
  • They analyzed the 17,391 women of the French Etude épidémiologique des femmes de la Mutuelle Générale de l'Education Nationale (E3N)-European Prospective Investigation into Cancer and Nutrition (EPIC) cohort who underwent a colonoscopy during follow-up (1993-2002), including 1,408 who developed a first colorectal adenoma.
  • In Cox multivariate proportional hazard regression models, obesity was associated with an increased colorectal adenoma risk (hazard ratio = 1.53, 95% confidence interval: 1.21, 1.94).
  • This association was restricted to left colon adenomas (P(homogeneity) = 0.05 and 0.01 for colon vs. rectum and right vs. left colon, respectively), with a dose-effect relation observed from 22 kg/m².
  • A high waist circumference was also associated with left colon adenoma risk (hazard ratio = 1.81, 95% confidence interval: 1.36, 2.41).
  • Mean weight gain over 0.5 kg/year was associated with a 23% increased colorectal adenoma risk.