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1. Hindié E, Ugur O, Fuster D, O'Doherty M, Grassetto G, Ureña P, Kettle A, Gulec SA, Pons F, Rubello D, Parathyroid Task Group of the EANM: 2009 EANM parathyroid guidelines. Eur J Nucl Med Mol Imaging; 2009 Jul;36(7):1201-16
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  • [Title] 2009 EANM parathyroid guidelines.
  • The present guidelines were issued by the Parathyroid Task Group of the European Association of Nuclear Medicine.
  • The main focus was imaging of primary hyperparathyroidism.
  • Dual-tracer and single-tracer parathyroid scintigraphy protocols were discussed as well as the various modalities of image acquisition.
  • Primary hyperparathyroidism is an endocrine disorder with high prevalence, typically caused by a solitary parathyroid adenoma, less frequently (about 15%) by multiple parathyroid gland disease (MGD) and rarely (1%) by parathyroid carcinoma.
  • Patients with MGD may have a double adenoma or hyperplasia of three or all four parathyroid glands.
  • In this new era, the success of targeted parathyroid surgery depends not only on an experienced surgeon, but also on a sensitive and accurate imaging technique.
  • Scintigraphy should also report on thyroid nodules that may cause confusion with a parathyroid adenoma or require concurrent surgical resection.
  • The guidelines also discuss aspects related to radio-guided surgery of hyperparathyroidism and imaging of chronic kidney disease patients with secondary hyperparathyroidism.
  • [MeSH-major] Parathyroid Glands
  • [MeSH-minor] Humans. Hyperparathyroidism / diagnosis. Hyperparathyroidism / pathology. Hyperparathyroidism / physiopathology. Hyperparathyroidism / surgery. Image Processing, Computer-Assisted. Iodine Radioisotopes / pharmacokinetics. Radiometry. Sodium Pertechnetate Tc 99m / pharmacokinetics. Subtraction Technique. Technetium Tc 99m Sestamibi / pharmacokinetics. Tissue Distribution. Tomography, Emission-Computed, Single-Photon. Tomography, X-Ray Computed

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  • (PMID = 19471928.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 971Z4W1S09 / Technetium Tc 99m Sestamibi; A0730CX801 / Sodium Pertechnetate Tc 99m
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2. Weigel TL, Murphy J, Kabbani L, Ibele A, Chen H: Radioguided thoracoscopic mediastinal parathyroidectomy with intraoperative parathyroid hormone testing. Ann Thorac Surg; 2005 Oct;80(4):1262-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radioguided thoracoscopic mediastinal parathyroidectomy with intraoperative parathyroid hormone testing.
  • BACKGROUND: Primary hyperparathyroidism is the leading cause of hypercalcemia in the United States.
  • The goal of this study was to evaluate the feasibility of radioguided thoracoscopic mediastinal parathyroidectomy and intraoperative immunoreactive parathyroid hormone (iPTH) level testing to guide completeness of resection.
  • Parathyroid excision was confirmed by ex vivo measurement of specimen radioactivity greater than 20% of background.
  • RESULTS: Four patients had mediastinal parathyroid glands successfully localized and resected thoracoscopically.
  • Mean weight of the excised parathyroid adenoma was 1,714 mg (range, 425 to 4,400 mg).
  • One patient underwent radioguided resection of a second enlarged cervical parathyroid adenoma at the same setting when his intraoperative iPTH levels failed to fall below 50% of baseline, despite resection of a 440 mg mediastinal parathyroid gland.
  • All mediastinal parathyroid glands resected were confirmed adenomas on final histologic examination.
  • Radioguidance facilitates parathyroid localization.
  • Ex vivo specimen radioactivity of greater than 20% of background confirms parathyroid resection and obviates the need for costly, time-consuming frozen section analysis.
  • A 50% decrease in baseline iPTH level 5 minutes postresection confirms complete resection of parathyroid adenomas.
  • [MeSH-major] Hyperparathyroidism, Primary / blood. Hyperparathyroidism, Primary / surgery. Parathyroid Hormone / blood. Parathyroid Neoplasms / blood. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods. Thoracoscopy / methods

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  • (PMID = 16181851.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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3. Chan AP, Wan IY, Wong RH, Hsin MK, Underwood MJ: Robot-assisted excision of ectopic mediastinal parathyroid adenoma. Asian Cardiovasc Thorac Ann; 2010 Feb;18(1):65-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Robot-assisted excision of ectopic mediastinal parathyroid adenoma.
  • Robot-assisted excision of an ectopic parathyroid adenoma in the superior mediastinum was performed in a 57-year-old man.
  • Identification of the ectopic parathyroid adenoma was facilitated by the 3-dimensional images of the da Vinci robotic system, and resection was achieved using EndoWrist instruments.
  • Robot-assisted excision of parathyroid adenoma located in the relatively inaccessible superior mediastinum proved to be feasible.
  • [MeSH-major] Adenoma / surgery. Mediastinum / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods. Robotics / methods

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  • (PMID = 20124300.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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4. Schachter PP, Ayesh S, Matouk I, Schneider T, Czerniak A, Hochberg A: Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue. Arch Pathol Lab Med; 2007 Jan;131(1):126-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue.
  • CONTEXT: Differentiation between adenoma and hyperplasia or even normal parathyroid tissue is difficult and based mainly on the surgeon's skill.
  • Exploration of genes that express differentially in these various tissues using microarrays and other sophisticated research tools will enable identification and perhaps development of new methods of perioperative diagnosis.
  • OBJECTIVE: To assemble a panel of kinase genes to differentiate parathyroid adenoma from normal and hyperplastic parathyroid tissue.
  • DESIGN: RNA was extracted from adenoma, hyperplasia, and normal parathyroid tissue and hybridized to a microarray containing 359 human cDNAs of known kinase genes.
  • RESULTS: The ratio values considered significant (<0.5 or >1.5) suggest that genes up-regulated in parathyroid adenoma are those responsible for blood vessel angiogenesis and genes belonging to the cyclin-dependent kinase inhibitor groups.
  • Genes down-regulated in parathyroid adenoma are related to cellular growth and apoptosis--genes from the mitogen-activated protein kinase group and DNA-dependent protein kinase group.
  • An interesting gene down-regulated in the parathyroid adenoma samples is related to the serine/threonine protein kinases that exert a key function in calcium handling.
  • CONCLUSIONS: The kinase genes panel presented can be used to differentiate parathyroid adenoma from normal and hyperplastic parathyroid tissue in particular when histopathology fails to provide a decisive diagnosis.
  • [MeSH-major] Adenoma / genetics. Hyperparathyroidism, Primary / genetics. Parathyroid Neoplasms / genetics. Phosphotransferases / genetics

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  • (PMID = 17227113.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.- / Phosphotransferases
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5. Ogawa T, Tsuji E, Kanauchi H, Yamada K, Mimura Y, Kaminishi M: Excision of postesophageal parathyroid adenoma in posterior mediastinum with intraoperative 99mTechnetium sestamibi scanning. Ann Thorac Surg; 2007 Nov;84(5):1754-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Excision of postesophageal parathyroid adenoma in posterior mediastinum with intraoperative 99mTechnetium sestamibi scanning.
  • Although approximately 25% of parathyroid tumors in patients with primary hyperparathyroidism are located in the mediastinum, nearly all these tumors can be removed through cervical exploration.
  • The mediastinal tumors are usually located in the inferior parathyroid gland, and the ectopic mediastinal tumors derived from the superior glands are extremely rare.
  • We present a case of retroesophageal mediastinal parathyroid adenoma that developed in the left superior parathyroid gland.
  • [MeSH-major] Adenoma / surgery. Choristoma / surgery. Mediastinal Neoplasms / surgery. Parathyroid Neoplasms / surgery. Technetium Tc 99m Sestamibi

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  • (PMID = 17954108.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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6. Portela-Gomes GM, Grimelius L, Stridsberg M: Secretogranin III in human neuroendocrine tumours: a comparative immunohistochemical study with chromogranins A and B and secretogranin II. Regul Pept; 2010 Nov 30;165(1):30-5
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  • The expression of SgIII agreed well with that of CgA, CgB and SgII, with exceptions of phaeochromocytomas, where more CgB and SgII immunoreactive cells were observed and parathyroid adenomas, which were only stained by CgA.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20550951.001).
  • [ISSN] 1873-1686
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Chromogranin B; 0 / Chromogranins; 0 / Secretogranin II; 0 / secretogranin III
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7. Caliumi C, Cotesta D, Petramala L, Lorio M, Salvati M, Filetti S, De Toma G, D'Erasmo E, Letizia C: An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. Tumori; 2006 Mar-Apr;92(2):178-80
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  • [Title] An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma.
  • The case of a 50-year-old woman with cerebral meningioma and concomitant parathyroid adenoma and papillary thyroid carcinoma is presented.
  • Even though the patient's clinical condition was good, a calcium-phosphorus metabolism test confirmed high plasma levels of ionized calcium and parathyroid hormone.
  • Thyroid and parathyroid ultrasonography revealed multinodular goiter and a parathyroid lesion confirmed by 99mTc-TCO4 / 99mTc-MIBI scintigraphy.
  • Histological examination revealed a parathyroid adenoma and a small papillary carcinoma of 0.4 cm in the right thyroid lobe.
  • As far as we know, this patient is the third case of meningioma associated with parathyroid adenoma and papillary thyroid carcinoma described in the literature.
  • [MeSH-major] Adenoma / diagnosis. Brain Neoplasms / diagnosis. Carcinoma, Papillary / diagnosis. Meningioma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parathyroid Neoplasms / diagnosis. Thyroid Neoplasms / diagnosis


8. Hong JJ, Schrump DS, Hughes MS: Image of the month. Cystic parathyroid adenoma. Arch Surg; 2010 Jul;145(7):705
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image of the month. Cystic parathyroid adenoma.
  • [MeSH-major] Adenoma / radiography. Adenoma / surgery. Cysts. Parathyroid Neoplasms / radiography. Parathyroid Neoplasms / surgery. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Male. Mediastinum. Middle Aged. Monitoring, Intraoperative. Parathyroid Hormone / blood. Thoracotomy

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  • (PMID = 20644137.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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9. Das K, Stone N, Kendall C, Fowler C, Christie-Brown J: Raman spectroscopy of parathyroid tissue pathology. Lasers Med Sci; 2006 Dec;21(4):192-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Raman spectroscopy of parathyroid tissue pathology.
  • Primary hyperparathyroidism (HPT) in 80% of patients is due to a solitary parathyroid adenoma, while in 20% multigland pathology exists, usually hyperplasia [Scott-Coombes, Surgery, 21(12):309-312, 2003].
  • Despite recent advances in minimally invasive parathyroidectomy, better preoperative localisation techniques and intraoperative parathyroid hormone (PTH) monitoring, a 4% failure rate [Grant CS, Thompson G, Farley D, Arch Surg, 140:47-479, 2005] persists making accurate differentiation between adenomas and hyperplasia of prime importance.
  • We investigated the ability of Raman spectroscopy to accurately differentiate between parathyroid adenomas and hyperplasia.
  • Raman spectra were measured at defined points on the parathyroid tissue sections using a bench-top microscopy system.
  • Multivariate analysis of the spectra was carried out to construct a diagnostic algorithm correlating spectral results with the histopathological diagnosis.
  • Detection sensitivity for parathyroid adenomas was 95% and hyperplasia was 93%.
  • These preliminary results indicate that Raman spectroscopy is potentially an excellent tool to differentiate between parathyroid adenomas and hyperplasia.
  • [MeSH-major] Parathyroid Glands / pathology. Parathyroid Neoplasms / pathology. Spectrum Analysis, Raman
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Humans. Hyperparathyroidism, Primary / pathology. Hyperplasia. Multivariate Analysis. Sensitivity and Specificity

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  • (PMID = 17024320.001).
  • [ISSN] 0268-8921
  • [Journal-full-title] Lasers in medical science
  • [ISO-abbreviation] Lasers Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Turgut B, Elagoz S, Erselcan T, Koyuncu A, Dokmetas HS, Hasbek Z, Ozdemir S, Aydin C: Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume. Cancer Biother Radiopharm; 2006 Dec;21(6):579-90
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  • [Title] Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume.
  • In addition to tumor size, it has been suggested that P-glycoprotein (P-gp) expression and/or oxyphilic cell content in parathyroid adenomas has an important influence on the results of technetium 99m methoxyisobutylisonitrile (Tc-99m MIBI) parathyroid imaging.
  • AIM: In this study, we compared the results of MIBI parathyroid imaging and immunohistochemical analysis (IHA) of P-gp expression, oxyphilic cell content, and tumoral tissue volume in parathyroid adenomas.
  • MATERIALS AND METHODS: Forty (40) patients (36 female and 4 male; mean age, 53.2 +/- 8.16 years) with hyperparathyroidism who had undergone surgery were included in this study.
  • Preoperatively, "double phase" parathyroid scintigraphy with Tc-99m MIBI (including imaging of the neck and mediastinum) was performed in all patients.
  • In resected parathyroid tissues, P-gp expression and percentage of oxyphilic cell content were analyzed with IHA in 34 patients.
  • RESULTS: Three (3) of the resected parathyroid tissues were hyperplastic parathyroid tissue, whereas 31 of the tissues were parathyroid adenoma (mean volume, 1.99 +/- 1.93 mL).
  • In Tc-99m MIBI parathyroid scintigraphy, 70% of the parathyroid adenoma/hyperplastic parathyroid tissue was detected in correct localization; at US, this rate was 46.8%.
  • According to the resected parathyroid tissue localization at surgery, sensitivity, accuracy, positive predictive value, and prevalence in scintigraphy were 82.3%, 70%, 82.3%, and 85%, respectively.
  • In 12 of 19 patients (63%) who had parathyroid tissue < 1 mL and in 15 of 24 patients (62.5%) who had oxyphilic cell content < 10%, lesions were also detected correctly with MIBI scintigraphy.
  • However, P-gp expression, oxyphilic cell content, and tumoral volume may have not a main effect on MIBI parathyroid scintigraphy results in parathyroid adenoma.
  • [MeSH-major] Organotechnetium Compounds. Oxyphil Cells / metabolism. Oxyphil Cells / pathology. P-Glycoproteins / metabolism. Parathyroid Neoplasms / metabolism. Parathyroid Neoplasms / radiography

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  • (PMID = 17257073.001).
  • [ISSN] 1084-9785
  • [Journal-full-title] Cancer biotherapy & radiopharmaceuticals
  • [ISO-abbreviation] Cancer Biother. Radiopharm.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / P-Glycoproteins
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11. Cebesoy O, Karakok M, Arpacioglu O, Baltaci ET: Brown tumor with atypical localization in a normocalcemic patient. Arch Orthop Trauma Surg; 2007 Sep;127(7):577-80
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  • Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies.
  • Hyperparathyroidism is usually associated with high levels of calcium.
  • Being normocalcemic and having the tumor on foot only without any other skeletal system involvement have led to a difficulty in establishing the diagnosis in our case.
  • Even though serum calcium levels are routinely checked in many clinics parathormone levels should also be looked for differential diagnosis, as this case confirms, in cases with osteolytic bone tumors that causes expansion even if the patient is normocalcemic.
  • [MeSH-major] Adenoma / pathology. Bone Neoplasms / secondary. Metatarsal Bones / pathology. Parathyroid Neoplasms / diagnosis

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  • (PMID = 17377798.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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12. Ogilvie JB, Clark OH: Parathyroid surgery: we still need traditional and selective approaches. J Endocrinol Invest; 2005 Jun;28(6):566-9
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  • [Title] Parathyroid surgery: we still need traditional and selective approaches.
  • Since the first parathyroidectomy in 1925, the traditional bilateral cervical approach has been the gold standard surgical treatment for patients with primary hyperparathyroidism, with a success rate >95%.
  • Over the past decade, the focus on minimally invasive surgery has led to the development of several innovative approaches to the parathyroid glands including the focused, radio-guided, video-assisted and videoscopic parathyroidectomy.
  • Improvements in pre-operative parathyroid localization studies as well as the use of the intraoperative PTH assay have made these minimally invasive approaches possible, and they have been proven to be safe and effective for the solitary parathyroid adenoma.
  • For patients with multiple gland disease or equivocal localization studies, the traditional bilateral approach remains the standard of care.
  • [MeSH-major] Parathyroid Diseases / surgery. Parathyroidectomy / methods
  • [MeSH-minor] Adenoma / surgery. Humans. Hyperparathyroidism / surgery. Parathyroid Glands / surgery. Parathyroid Hormone / blood. Parathyroid Neoplasms / surgery. Reoperation. Thyroid Neoplasms / complications. Thyroid Neoplasms / surgery. Ultrasonography

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  • [CommentIn] J Endocrinol Invest. 2005 Jun;28(6):570-3 [16117202.001]
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  • (PMID = 16117201.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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13. Wiseman SM, Levine D, Sexsmith G, Ling H: Aortopulmonary window parathyroid adenoma. J Am Coll Surg; 2009 Sep;209(3):412
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  • [Title] Aortopulmonary window parathyroid adenoma.
  • [MeSH-major] Parathyroid Neoplasms / surgery
  • [MeSH-minor] Choristoma. Diagnosis, Differential. Female. Humans. Mediastinal Diseases / diagnosis. Mediastinal Diseases / surgery. Middle Aged. Parathyroid Glands. Thoracotomy

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  • (PMID = 19717051.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Vu DH, Erickson RA: Endoscopic ultrasound-guided fine-needle aspiration with aspirate assay to diagnose suspected mediastinal parathyroid adenomas. Endocr Pract; 2010 May-Jun;16(3):437-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic ultrasound-guided fine-needle aspiration with aspirate assay to diagnose suspected mediastinal parathyroid adenomas.
  • OBJECTIVE: To describe our experience with mediastinal parathyroid adenomas diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and measurement of parathyroid hormone.
  • RESULTS: Patient 1 was a 54-year-old man with persistently elevated serum calcium and parathyroid hormone concentrations despite removal of a right inferior parathyroid adenoma.
  • The parathyroid hormone concentration measured in the aspirated material was 1800 pg/mL.
  • Pathologic examination of the resected specimen revealed a 29.7-g parathyroid adenoma.
  • Patient 2 was an 86-year-old woman with recurrent hyperparathyroidism.
  • The parathyroid hormone concentration measured in the aspirated specimen was 6905 pg/mL.
  • CONCLUSIONS: Preoperative localization of recurrent or persistent hyperparathyroidism is often difficult.
  • This technique may be a useful adjunct in diagnosing mediastinal parathyroid adenomas.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Mediastinum / pathology. Parathyroid Neoplasms / diagnosis

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  • (PMID = 20061273.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Liau SS, Hill-Cawthorne G, Wishart GC, Wells FC: Use of an improvised sternal retractor for mediastinal parathyroidectomy through a cervical incision. Ann R Coll Surg Engl; 2008 Jul;90(5):430-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / instrumentation. Surgical Instruments

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  • (PMID = 18642425.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2645761
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16. Al-Mashat F, Sibiany A, Faleh D, Kary K, Alfi AY, El-Lakany MM: Mediastinal parathyroid adenoma. Saudi J Kidney Dis Transpl; 2009 Sep;20(5):826-30
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  • [Title] Mediastinal parathyroid adenoma.
  • We present two cases that developed clinical, biochemical and radiological evidences of primary and secondary hyperparathyroidism.
  • In the first case the adenoma was removed through a transcervical incision and in the second case the supernumerary adenoma was removed through sternotomy.
  • [MeSH-major] Adenoma / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy. Sternum / surgery
  • [MeSH-minor] Adult. Biomarkers / blood. Calcium / blood. Female. Humans. Hyperparathyroidism, Primary / etiology. Hyperparathyroidism, Secondary / etiology. Magnetic Resonance Imaging. Middle Aged. Parathyroid Hormone / blood. Radiopharmaceuticals. Technetium. Technetium Tc 99m Sestamibi. Thallium Radioisotopes. Treatment Outcome

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  • (PMID = 19736482.001).
  • [ISSN] 1319-2442
  • [Journal-full-title] Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • [ISO-abbreviation] Saudi J Kidney Dis Transpl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Parathyroid Hormone; 0 / Radiopharmaceuticals; 0 / Thallium Radioisotopes; 7440-26-8 / Technetium; 971Z4W1S09 / Technetium Tc 99m Sestamibi; SY7Q814VUP / Calcium
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17. Henry JF: Reoperation for primary hyperparathyroidism: tips and tricks. Langenbecks Arch Surg; 2010 Feb;395(2):103-9
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  • [Title] Reoperation for primary hyperparathyroidism: tips and tricks.
  • Reoperation for primary hyperparathyroidism (PHPT) remains a major challenge for both the patient and surgeons.
  • Before considering reoperation, the surgeon must confirm the diagnosis of PHPT and assess patient risk factors.
  • The goal of reoperative surgery is to excise the abnormal parathyroid gland(s) and limit exploration to help minimize the potential complications.
  • A thorough knowledge of the anatomy and an understanding of the embryonic development of the parathyroid glands are also the keys to successful localization.
  • If the lesion sought is a solitary adenoma, an open-focused approach can be proposed.
  • In some cases, cryopreservation of parathyroid tissue and judicious use of parathyroid transplantation can be useful.
  • With experienced parathyroid surgeons, the success rate of reoperations can be as high as 95%.
  • It is too early to evaluate the real risk of persistent or recurrent disease following minimally invasive techniques, but any attempt to limit the extent of the primary procedure will be insignificant if the risk of persistent or recurrent disease is increased.
  • [MeSH-major] Hyperparathyroidism / surgery. Reoperation / methods
  • [MeSH-minor] Adenoma / complications. Carcinoma / complications. Cryopreservation. Humans. Medical History Taking. Minimally Invasive Surgical Procedures / methods. Neoplasm Recurrence, Local / complications. Parathyroid Glands / abnormalities. Parathyroid Glands / embryology. Parathyroid Glands / transplantation. Parathyroid Neoplasms / complications. Patient Selection. Recurrence. Risk Assessment. Risk Factors. Time Factors. Transplantation, Autologous. Treatment Outcome

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  • (PMID = 19924438.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Lectures
  • [Publication-country] Germany
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18. Freriks K, den Heijer M, Bonenkamp JJ, Biert J, Sweep CG, Hermus AR: [Intraoperative parathyroid hormone measurement in patients with primary hyperparathyroidism; particularly valuable for suspected solitary parathyroid adenoma and re-operation]. Ned Tijdschr Geneeskd; 2008 Jan 5;152(1):28-32
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  • [Title] [Intraoperative parathyroid hormone measurement in patients with primary hyperparathyroidism; particularly valuable for suspected solitary parathyroid adenoma and re-operation].
  • OBJECTIVE: Analysis of the value of intraoperative parathormone (PTH) measurement in patients with primary hyperparathyroidism.
  • The success rate was correctly predicted as follows: in subgroups of patients with MEN-1 syndrome, 85%, patients after exclusion of MEN-1, 94%, and patients in whom a solitary adenoma was likely after preoperative localization studies, 97%.
  • In 13% of the total number of operations, PTH-measurements led to further exploration, removal of additional parathyroid tissue and normocalcemia postoperatively.
  • In patients without MEN-1 syndrome, in whom a solitary adenoma was likely on the basis of preoperative investigations, it was possible to limit the operation to a unilateral procedure in 87%.
  • CONCLUSION: In the majority of patients with primary hyperparathyroidism, intraoperative PTH-measurement in combination with preoperative imaging studies leads to patients being cured with a unilateral instead of a bilateral operation.
  • [MeSH-major] Adenoma / surgery. Hyperparathyroidism, Primary / blood. Monitoring, Intraoperative / methods. Parathyroid Hormone / blood. Parathyroid Neoplasms / surgery

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  • (PMID = 18240759.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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19. Abboud B, Sleilaty G, Helou E, Mansour E, Tohme C, Noun R, Sarkis R: Existence and anatomic distribution of double parathyroid adenoma. Laryngoscope; 2005 Jun;115(6):1128-31
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  • [Title] Existence and anatomic distribution of double parathyroid adenoma.
  • BACKGROUND: Double parathyroid adenomas occur in 2% to 15% of primary hyperparathyroidism cases, but the very existence of double adenomas has been controversial.
  • This study was conducted to evaluate the clinical significance and anatomic distribution of parathyroid double adenomas.
  • STUDY DESIGN: Mono-institutional retrospective study of the medical records of 183 unselected consecutive patients who underwent intervention for primary hyperparathyroidism between 1996 and 2003.
  • RESULTS: A total of 14 (7.65%) patients were found to have double parathyroid adenomas.
  • Intraoperative parathyroid hormone (PTH) levels were measured in every case.
  • Two enlarged parathyroid glands were identified in four possible configurations: two both superior, one both inferior, two both right, three both left, two right superior and left inferior, and three left superior and right inferior.
  • There was a preferential crossed bilateral distribution of double adenomas.
  • In all patients, intraoperative PTH levels dropped by at least 50% from baseline after removal of both abnormal parathyroid glands.
  • CONCLUSION: The drop in intraoperative PTH levels and maintenance of normocalcemia postoperatively confirm previous reports that double adenomas do exist and are not simply missed cases of four-gland hyperplasia.
  • There was a preferential crossed bilateral distribution of double adenomas in this series.
  • [MeSH-major] Adenoma / pathology. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Hyperparathyroidism / pathology. Male. Middle Aged. Parathyroid Hormone / blood. Retrospective Studies

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  • (PMID = 15933536.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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20. Perrier ND, Edeiken B, Nunez R, Gayed I, Jimenez C, Busaidy N, Potylchansky E, Kee S, Vu T: A novel nomenclature to classify parathyroid adenomas. World J Surg; 2009 Mar;33(3):412-6
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  • [Title] A novel nomenclature to classify parathyroid adenomas.
  • BACKGROUND: A uniform and reliable description of the exact locations of adenomatous parathyroid glands is necessary for accurate communications between surgeons and other specialists.
  • We developed a nomenclature that provides a precise means of communicating the most frequently encountered parathyroid adenoma locations.
  • The system uses the letters A-G to describe exact gland locations.
  • RESULTS: A type A parathyroid gland is a gland that originates from a superior pedicle, lateral to the recurrent laryngeal nerve compressed within the capsule of the thyroid parenchyma.
  • A type B gland is a superior gland that has fallen posteriorly into the tracheoesophageal groove and is in the same cross-sectional plane as the superior portion of the thyroid parenchyma.
  • A type C gland is a gland that has fallen posteriorly into the tracheoesophageal groove and on a cross-sectional view lies at the level of or below the inferior pole of the thyroid gland.
  • A type D gland lies in the midregion of the posterior surface of the thyroid parenchyma, near the junction of the recurrent laryngeal nerve and the inferior thyroid artery or middle thyroidal vein; because of this location, dissection is difficult.
  • A type E gland is an inferior gland close to the inferior pole of the thyroid parenchyma, lying in the lateral plane with the thyroid parenchyma and anterior half of the trachea.
  • A type F gland is an inferior gland that has descended (fallen) into the thyrothymic ligament or superior thymus; it may appear to be "ectopic" or within the superior mediastinum.
  • An anterior-posterior view shows the type F gland to be anterior to the trachea.
  • A type G gland is a rare, truly intrathyroidal parathyroid gland.
  • CONCLUSIONS: A reproducible nomenclature can provide a means of consistent communication about parathyroid adenoma location.
  • If uniformly adopted, it has the potential to reliably communicate exact gland location without lengthy descriptions.
  • [MeSH-major] Interdisciplinary Communication. Parathyroid Neoplasms / classification

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  • (PMID = 19148701.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Harris B, Bailey D, Roach P, Marshman D, McElduff A, King G: Use of fusion imaging to localize an ectopic thoracic parathyroid adenoma. Ann Thorac Surg; 2006 Aug;82(2):719-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of fusion imaging to localize an ectopic thoracic parathyroid adenoma.
  • We report the use of fused computed tomography and single photon emission computed tomography parathyroid (99m technetium)-sestamibi images to localize an ectopic parathyroid adenoma.
  • [MeSH-major] Adenoma / radionuclide imaging. Choristoma / radionuclide imaging. Mediastinal Diseases / radionuclide imaging. Parathyroid Neoplasms / radionuclide imaging. Pregnancy Complications, Neoplastic / radionuclide imaging. Technetium Tc 99m Sestamibi. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 16863795.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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22. Gilat H, Cohen M, Feinmesser R, Benzion J, Shvero J, Segal K, Ulanovsky D, Shpitzer T: Minimally invasive procedure for resection of a parathyroid adenoma: the role of preoperative high-resolution ultrasonography. J Clin Ultrasound; 2005 Jul-Aug;33(6):283-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive procedure for resection of a parathyroid adenoma: the role of preoperative high-resolution ultrasonography.
  • PURPOSE: Solitary adenoma of the parathyroid is the major cause of primary hyperparathyroidism.
  • Many centers advocate a minimally invasive surgical approach, wherein the surgeon explores only a localized area of the neck according to the preoperative imaging evaluation, and the adenoma is resected without histological sampling from the other parathyroid glands.
  • The aim of this study was to evaluate the ability of high-resolution ultrasonography (US) to localize adenomas preoperatively and thereby aid in patient selection for minimal procedures.
  • METHODS: We reviewed the medical records of 77 consecutive patients who underwent resection of a parathyroid adenoma following ultrasonographic imaging between 2001 and 2002, and we assessed the accuracy of the preoperative localization of the adenomas as well as the efficacy of the minimally invasive procedure.
  • RESULTS: US correctly localized the adenoma to a specific quadrant of the neck in 87% of the cases and to a specific side of the neck in 94%.
  • Its sensitivity was not reduced by the presence of nodular disease of the thyroid gland.
  • CONCLUSIONS: US performed by a skilled operator is a reliable tool for adenoma localization prior to minimally invasive parathyroidectomy.
  • If there is a high clinical suspicion of adenoma in the presence of negative imaging studies, bilateral neck exploration should be performed.
  • [MeSH-major] Adenoma / surgery. Minimally Invasive Surgical Procedures / methods. Parathyroid Glands / ultrasonography. Parathyroid Neoplasms / surgery. Preoperative Care / methods

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  • (PMID = 16134156.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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23. Shaheen F, Chowdry N, Gojwari T, Wani AI, Khan S: Role of cervical ultrasonography in primary hyperparathyroidism. Indian J Radiol Imaging; 2008 Nov;18(4):302-5
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  • [Title] Role of cervical ultrasonography in primary hyperparathyroidism.
  • AIM: To evaluate the role of USG in the preoperative localization of parathyroid adenomas in patients with symptomatic hyperparathyroidism and to compare its usefulness with that of scintigraphy scan and postoperative findings.
  • MATERIAL AND METHODS: Twenty-five patients with symptomatic primary hyperparathyroidism were subjected to USG of the neck and nuclear scintigraphy, followed by surgery.
  • RESULTS: The 25 patients had a total of 28 abnormal glands: 22 solitary adenomas, and 6 multiple adenomas (two each in three patients).
  • USG detected 20 out of 22 solitary adenomas and three out of six multiple adenomas.
  • CONCLUSION: As limited neck dissection for primary hyperparathyroidism becomes increasingly popular, USG has been found to be a sensitive, specific, and easily available noninvasive investigation for parathyroid localization.
  • It can be easily offered to patients as a method for preoperative localization prior to limited parathyroid surgery outside tertiary care settings.

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  • (PMID = 19774186.001).
  • [ISSN] 0971-3026
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2747464
  • [Keywords] NOTNLM ; Primary hyperparathyroidism / Tc-sestamibi scan / ultrasonography
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24. Krishnamoorthy P, Alyaarubi S, Abish S, Gale M, Albuquerque P, Jabado N: Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease. Pediatrics; 2006 Aug;118(2):e537-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease.
  • We report a case of bone pain associated with primary hyperparathyroidism in a patient with sickle cell disease.
  • Phosphorus level was 0.82 mmol/L (range: 0.90-1.50), alkaline phosphatase level was elevated at 519 U/L (range: 10-170), and parathyroid hormone level was extremely high at 1645 pg/mL (range: 10-60).
  • Ultrasonography of the neck and a Sestamibi scan revealed a single left inferior parathyroid adenoma adjacent to the thyroid lobe.
  • The patient was diagnosed with primary hyperparathyroidism.
  • Fluid hydration, hydrocortisone, calcitonin, and bisphosphonates were initiated for acute hypercalcemia management before surgical excision of the left parathyroid adenoma.
  • Two years postsurgery, she has normal renal function, calcium, and parathyroid hormone levels.
  • The decrease in pain episodes, even if it coincided with the treatment of primary hyperparathyroidism, may still reflect the natural evolution of sickle cell disease in this patient.
  • However, the high morbidity associated with primary hyperparathyroidism was successfully prevented in this patient.
  • Primary hyperparathyroidism is rare in childhood.
  • In a recent study, it occurred more commonly in female adolescents and was because of a single adenoma, as in our patient.
  • Significant morbidity, mainly secondary to renal dysfunction, was because of the delay in diagnosis after the onset of symptoms (2.0-4.2 years), emphasizing the need for a rapid diagnosis.
  • There is no known association between sickle cell disease and primary hyperparathyroidism, and this case is most probably a random occurrence.
  • Because management may vary, we suggest that care providers consider the diagnosis of vaso-occlusive crisis as the diagnosis of exclusion and that other etiologies for pain be envisaged in this patient population, especially in the presence of prolonged pain or unusual clinical, radiologic, or biological findings.
  • [MeSH-major] Adenoma / complications. Anemia, Sickle Cell / complications. Arthralgia / etiology. Back Pain / etiology. Hyperparathyroidism / diagnosis. Knee Joint. Parathyroid Neoplasms / complications. Vascular Diseases / diagnosis
  • [MeSH-minor] Adolescent. Analgesics, Opioid / therapeutic use. Bone Resorption / etiology. Diagnosis, Differential. Emergency Service, Hospital. Female. Humans. Hydroxyurea / therapeutic use. Hypercalcemia / etiology. Parathyroid Hormone / blood. Recurrence. Treatment Refusal


25. Toi PCh, Varghese RG, Ramdas A, Dasiah SD: Case report of parathyroid carcinoma with raised urinary catecholamines: a diagnostic dilemma. Indian J Pathol Microbiol; 2007 Apr;50(2):389-91
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  • [Title] Case report of parathyroid carcinoma with raised urinary catecholamines: a diagnostic dilemma.
  • Parathyroid carcinoma is often misdiagnosed as thyroid carcinoma clinically and also with fine needle aspiration cytology.
  • Moreover in cases misdiagnosed as thyroid carcinoma pre operatively, raised urinary catecholamines may mislead to a diagnosis of MEN2 A.
  • We report a case of a patient admitted to the surgery department ofour hospital with a swelling in the thyroid region, raised urinary catecholamines and urinary VMA levels, with hypercalciuria and elevated parathyroid hormone levels.
  • It was clinically suspected as thyroid carcinoma with parathyroid adenoma and associated MEN 2A syndrome.
  • [MeSH-major] Catecholamines / urine. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / urine
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Multiple Endocrine Neoplasia Type 2a / diagnosis. Thyroid Neoplasms / diagnosis. Vanilmandelic Acid / urine

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  • (PMID = 17883086.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Catecholamines; 55-10-7 / Vanilmandelic Acid
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26. Enomoto K, Sakurai K, Amano S: [Experience of parathyroid cancer which required a differentiation from adenoma]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2325-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experience of parathyroid cancer which required a differentiation from adenoma].
  • We noted a thyroid gland mass by examination and referred for a further checkup.
  • The cervical echography evidence showed a mass image of the border regular in the back of inferior pole of left thyroid gland.
  • It also revealed a mass image with the calcification in the inferior pole of left lobe of thyroid gland at the same time.
  • We performed aspiration biopsy cytology for a thyroid gland mass, and it was class IIIa.
  • We also performed parathyroidectomy and left lobe of thyroid gland ablative surgery because of a diagnosis of the hyperparathyroidism confirmed a primary parathyroid adenoma.
  • Preoperative pathological diagnosis was adenoma.
  • However, histopathology laboratory findings showed it to be of adenocarcinoma of the parathyroid, which metastasized into the thyroid.
  • Many times parathyroid cancer preoperative diagnosis is inconclusive.
  • So we are reporting our experience with parathyroid cancer metastases to the thyroid for reference.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Hyperparathyroidism / etiology. Hyperparathyroidism / surgery. Male. Parathyroidectomy. Thyroid Neoplasms / secondary. Thyroidectomy

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  • (PMID = 21224561.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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27. Bano G, Mansour S, Nussey S: The association of primary hyperparathyroidism and primary ovarian failure: a de novo t(X; 2) (q22p13) reciprocal translocation. Eur J Endocrinol; 2008 Feb;158(2):261-3
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  • [Title] The association of primary hyperparathyroidism and primary ovarian failure: a de novo t(X; 2) (q22p13) reciprocal translocation.
  • CASE: A 40-year-old female presented with primary amenorrhoea at 17 years of age.
  • Gonadotrophins were elevated indicating primary ovarian failure.
  • She had raised corrected serum calcium and parathyroid hormone concentrations consistent with the diagnosis of primary hyperparathyroidism (PHPT).
  • She underwent parathyroidectomy at 24 weeks of gestation with removal of a large left inferior parathyroid adenoma which normalized her serum calcium.
  • Multipoint linkage from a genome-wide screen has identified a region of suggestive linkage on chromosome 2p13.3-14 in some cases of familial isolated hyperparathyroidism (FIHP).
  • CONCLUSION: To our knowledge, this is the first case of primary amenorrhoea due to reciprocal translocation involving chromosome 2 and the X chromosome associated with PHPT.


28. Komaba H, Takeda Y, Shin J, Tanaka R, Kakuta T, Tominaga Y, Fukagawa M: Reversed whole PTH/intact PTH ratio as an indicator of marked parathyroid enlargement: five case studies and a literature review. NDT Plus; 2008 Aug;1(Suppl 3):iii54-iii58
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  • [Title] Reversed whole PTH/intact PTH ratio as an indicator of marked parathyroid enlargement: five case studies and a literature review.
  • Parathyroid hormone (PTH) levels detected by intact PTH assays are generally higher than those detected by the whole PTH assay because the latter does not detect non-(1-84) PTH fragments, mainly PTH (7-84).
  • Rare exceptions to this rule have been reported in patients with severe primary or secondary hyperparathyroidism and parathyroid carcinoma.
  • We report five additional cases with the reversed whole PTH/intact PTH ratio associated with severe hyperparathyroidism in haemodialysis patients.
  • Three patients demonstrated enlargement of a single hypervascular gland, whereas the other two had undergone surgical parathyroidectomy and later showed recurrent hyperparathyroidism due to progressive autograft hyperplasia.
  • In the case of a single enlarged gland, the pathological pattern and heterogeneous expression of parathyroid adenomatosis 1/cyclin D1 suggested it to be a single nodule of uraemic hyperparathyroidism rather than sporadic primary adenoma.
  • These cases suggested that the reversed whole PTH/intact PTH ratio could be an indicator of marked parathyroid enlargement.

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  • (PMID = 25983975.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4421125
  • [Keywords] NOTNLM ; N-PTH / intact PTH / secondary hyperparathyroidism / single nodule / whole PTH
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29. Bharadwaj R, Nema SK, Pujahari AK, Patkar N: Parathyroid adenoma with ectopic intrathymic parathyroid--a case report. Indian J Pathol Microbiol; 2005 Jan;48(1):37-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid adenoma with ectopic intrathymic parathyroid--a case report.
  • Relevant investigations suggested a parathyroid adenoma.
  • The adenoma was excised along with a suprasternal swelling.
  • Histopathological examination confirmed the parathyroid adenoma of the mixed chief and oxyphil type.
  • An incidental finding of an intrathymic parathyroid was also made.
  • They are also subject to functional activity and hence necessitate removal by the surgeon at the first sitting, having detected these abnormally located parathyroid tissues.
  • [MeSH-major] Adenoma / pathology. Mediastinal Neoplasms / pathology. Parathyroid Glands / pathology. Parathyroid Neoplasms / pathology

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  • (PMID = 16758787.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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30. Lazar HL, Oates E, Beazley RM: Excision of a mediastinal parathyroid adenoma after coronary artery bypass surgery. Ann Thorac Surg; 2005 Sep;80(3):1105-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Excision of a mediastinal parathyroid adenoma after coronary artery bypass surgery.
  • In this report we describe the removal of a mediastinal parathyroid adenoma in a patient who had two previous coronary artery bypass graft procedures.
  • The surgical approach and intraoperative localization of the adenoma under these unusual circumstances are reviewed.
  • [MeSH-major] Adenoma / surgery. Mediastinal Neoplasms / surgery. Parathyroid Neoplasms / surgery

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  • (PMID = 16122500.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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31. Târcoveanu E, Moldovanu R, Georgescu S, Niculescu D, Lupaşcu C, Dimofte G: [Pancreatic endocrine tumors]. Chirurgia (Bucur); 2006 Mar-Apr;101(2):175-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the four cases of insulinoma (all females) the diagnosis was delayed by two to five years due to misinterpretation of neurological symptoms generated by hypoglycemia.
  • The diagnosis of insulinoma was based on Whipple triad, high plasma insulin levels associated with low plasma glucose levels, as well as the symptomatic relief after intravenous glucose injection.
  • The diagnosis was confirmed on pathological examination in all cases.
  • Both patients died and diagnosis of pancreatic endocrine tumors was post-mortem.
  • The two patients with Wermer syndrome also had ulcers complicated with haemorrhage and peritonitis and parathyroid adenoma.
  • One case also had ante-hypophyseal and pituitary adenoma and the other had thyroid colloid hypertrophy.
  • [MeSH-major] Gastrinoma / diagnosis. Insulinoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Medical Records. Middle Aged. Multiple Endocrine Neoplasia Type 1 / diagnosis. Pancreatectomy. Retrospective Studies. Romania. Splenectomy. Survival Analysis. Zollinger-Ellison Syndrome / diagnosis

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  • (PMID = 16752684.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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32. Bhansali A, Masoodi SR, Bhadada S, Mittal BR, Behra A, Singh P: Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgery. Clin Endocrinol (Oxf); 2006 Sep;65(3):340-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgery.
  • BACKGROUND: Among the parathyroid imaging techniques, ultrasonography (USG) has the advantage of convenience, easy availability and low cost.
  • OBJECTIVE: To study the role of USG in localization (side and/or site) of abnormal parathyroid glands in primary hyperparathyroidism (PHPT) and to compare with radionuclide scintigraphy and the 'gold standard', surgery.
  • METHODS: Forty-six consecutive patients undergoing USG of the anterior neck for a diagnosis of PHPT in whom a nuclear scan (technetium-99m sestamibi and/or thallium-201/technetium-99m pertechnetate scintigraphy) was also performed, were studied.
  • RESULTS: Forty-six patients had 52 abnormal parathyroid glands on surgical exploration and surgery was successful in all but one.
  • Forty-one patients had a single adenoma, four had multigland disease and one had a paraganglioma.
  • USG correctly localized the abnormal gland in 30 (73%) and scintigraphy was positive in 40 (98%) out of 41 patients with a single adenoma as confirmed on surgical exploration.
  • Scintigraphy showed a positive concordant test in all 30 patients with a single abnormal gland detected on USG and picked up 10 out of 11 abnormal glands where USG was negative.
  • The sensitivity and positive predictive value of USG for detecting a single abnormal gland was 73% and 100%, respectively, whereas the sensitivity and positive predictive value for scintigraphy was 98%.
  • In patients with multigland disease, USG missed 3 (30%) out of 10 and scintigraphy missed 6 (60%) out of 10 abnormal parathyroid glands as confirmed on surgical exploration (P < 0.05).
  • However, in two patients who had ectopic parathyroid gland, both the modalities localized the lesion in one (paraganglioma), whereas in the other neither test was helpful (left retro-esophageal).
  • CONCLUSION: USG is a convenient, affordable and useful modality to localize abnormal enlarged parathyroid glands in the majority of patients with PHPT.
  • [MeSH-major] Hyperparathyroidism, Primary / ultrasonography. Parathyroid Glands / ultrasonography
  • [MeSH-minor] Adenoma / radionuclide imaging. Adenoma / surgery. Adenoma / ultrasonography. Adolescent. Adult. Female. Humans. Male. Middle Aged. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / surgery. Parathyroid Neoplasms / ultrasonography. Prospective Studies. Radioisotopes. Sensitivity and Specificity. Statistics, Nonparametric. Technetium Tc 99m Sestamibi. Thallium Radioisotopes

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  • (PMID = 16918953.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radioisotopes; 0 / Thallium Radioisotopes; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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33. Khalid AN, Hollenbeak CS, Higginbotham BW, Stack BC Jr: Accuracy and definitive interpretation of preoperative technetium 99m sestamibi imaging based on the discipline of the reader. Head Neck; 2009 May;31(5):576-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Technetium 99m sestamibi scans have become a principal means of localizing parathyroid adenomas.
  • METHODS: We reviewed patients (N = 65) with digital images from an academic medical center with the diagnosis of primary hyperparathyroidism.
  • We assessed the willingness to define an adenoma's location, the interrater reliability, and the accuracy of technetium (Tc-99m) sestamibi read by a surgeon and a nuclear medicine physician.
  • RESULTS: There was poor correlation between both readers for assessment of quality of images (k = 0.54, 0.07) but very good correlation for adenoma location (k = 0.81).
  • CONCLUSION: Both readers had good accuracy in predicting the location of the parathyroid adenoma.
  • [MeSH-major] Adenoma / radionuclide imaging. Parathyroid Neoplasms / radionuclide imaging. Preoperative Care. Radiopharmaceuticals. Technetium Tc 99m Sestamibi
  • [MeSH-minor] General Surgery. Humans. Hyperparathyroidism, Primary / etiology. Nuclear Medicine. Observer Variation. Parathyroidectomy. Reproducibility of Results. Retrospective Studies

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  • (PMID = 19031406.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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34. Akalin A, Kilincal H, Kiper H: Unusual case of calciphylaxis associated with primary hyperparathyroidism without coexistent renal failure. Endocr Pract; 2008 Apr;14(3):368-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual case of calciphylaxis associated with primary hyperparathyroidism without coexistent renal failure.
  • OBJECTIVE: To report a case of calciphylaxis in a patient with primary hyperparathyroidism without coexistent renal failure.
  • Her serum calcium level was 16 mg/dL, serum phosphorus level was 2.13 mg/dL, and parathyroid hormone level was 2,257 pg/mL (reference range, 15 to 65).
  • A mass lesion was detected in the parathyroid region by both ultrasonography and a parathyroid scan.
  • The patient underwent a bilateral neck exploration, and a parathyroid adenoma measuring 3.5 by 1.5 by 1.2 cm was found on pathologic examination.
  • CONCLUSION: Severe primary hyperparathyroidism may be a factor leading to calciphylaxis, even in the absence of renal failure and a high calcium-phosphate product.
  • This potentially life-threatening condition should not be left untreated if the levels of serum calcium and parathyroid hormone are severely elevated.
  • [MeSH-major] Adenoma / complications. Calciphylaxis / etiology. Hyperparathyroidism, Primary / complications. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Renal Insufficiency / complications
  • [MeSH-minor] Calcium / blood. Female. Humans. Middle Aged. Parathyroid Hormone / blood. Prognosis

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  • (PMID = 18463046.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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35. Aziz MM, Khan AW, Uddin MF, Hasanat MA, Kader MA, Chowdhury AJ, Choudhury NA: Endoscopic para-thyroidectomy: a new approach. Mymensingh Med J; 2010 Jul;19(3):442-6
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  • Two patients (one male and one female) underwent endoscopic para-thyroidectomy for parathyroid adenoma at the Department of Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
  • Both patient's parathyroid hormone (PTH) level dropped to about one fourth the level in 12 to 20 minutes after enucleation (as compared to the immediate pre operative level).

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  • (PMID = 20639842.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
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36. Juhlin CC, Villablanca A, Sandelin K, Haglund F, Nordenström J, Forsberg L, Bränström R, Obara T, Arnold A, Larsson C, Höög A: Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification. Endocr Relat Cancer; 2007 Jun;14(2):501-12
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  • [Title] Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification.
  • Parafibromin is a protein product derived from the hyperparathyroidism 2(HRPT2) tumor suppressor geneand its inactivation has been coupled to familial and sporadic forms of parathyroid malignancy.
  • In this study, we have conducted immunohistochemistry on 33 parathyroid carcinomas (22 unequivocal and 11 equivocal) using four parafibromin antibodies directed to different parts of the protein.
  • Our findings show that 68% (15 out of 22) of the unequivocal carcinomas exhibited reduced expression of parafibromin while the 25 sporadic adenomas used as controls were entirely positive for parafibromin expression.
  • We conclude that parafibromin immunohistochemistry could be used as an additional marker for parathyroid tumor classification, where positive samples have low risk of malignancy, whereas samples with reduced expression could be either carcinomas or rare cases of adenomas likely carrying an HRPT2 mutation.
  • [MeSH-major] Adenoma / classification. Adenoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma / classification. Carcinoma / diagnosis. Parathyroid Neoplasms / classification. Parathyroid Neoplasms / diagnosis. Tumor Suppressor Proteins / analysis

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  • (PMID = 17639063.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers, Tumor; 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
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37. Ikeda Y, Takayama J, Takami H: Minimally invasive radioguided parathyroidectomy for hyperparathyroidism. Ann Nucl Med; 2010 May;24(4):233-40
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  • [Title] Minimally invasive radioguided parathyroidectomy for hyperparathyroidism.
  • Clinical or subclinical hyperparathyroidism (HPT) is one of the most common endocrine disorders.
  • In patients with HPT who meet the indications for parathyroidectomy, complete surgical resection of all hyperfunctioning parathyroid tissue is essential for the curative treatment.
  • The conventional surgical approach is bilateral neck exploration, whereas minimally invasive parathyroidectomy has been made possible by the introduction of (99m)Tc-sestamibi scintigraphy for preoperative localization of parathyroid adenomas.
  • In minimally invasive surgery, the surgeon expects some modalities that predict complete resection of all hyperfunctioning parathyroid glands.
  • The prevalence rate of (99m)Tc-sestamibi scanning for single parathyroid adenoma was widely accepted as 85-95%.
  • Intraoperative navigation using these devices provides the possibility of easy and definitive identification of parathyroid nodules during the operation.
  • [MeSH-major] Hyperparathyroidism / surgery. Minimally Invasive Surgical Procedures / methods. Parathyroidectomy / methods. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Humans. Intraoperative Period. Parathyroid Hormone / metabolism

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  • (PMID = 20333484.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  • [Number-of-references] 45
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38. Wilkins BJ, Lewis JS Jr: Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery. Head Neck Pathol; 2009 Jun;3(2):140-9
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  • [Title] Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery.
  • Parathyroid carcinoma is a rare malignancy, and only accounts for 0.5-2% of cases of primary hyperparathyroidism.
  • Less than 10% of parathyroid carcinomas are non-functional, and as such, they have been rarely reported in the literature.
  • Here we report the first case of non-functional parathyroid carcinoma with negative margins, and review the literature on this rare entity.
  • Whether functional or non-functional, parathyroid carcinoma can often be difficult to differentiate from benign parathyroid adenoma.
  • While diagnosis has been based on clinical and histological criteria, recent data concerning the molecular underpinnings of parathyroid carcinoma may allow for improved accuracy in distinguishing benign and malignant parathyroid tumors.
  • [MeSH-major] Parathyroid Neoplasms / pathology. Parathyroid Neoplasms / surgery

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  • (PMID = 19644546.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Hypoglycemic Agents; 1J444QC288 / Amlodipine; 9100L32L2N / Metformin
  • [Number-of-references] 41
  • [Keywords] NOTNLM ; Carcinoma / Non-functional / Parafibromin / Parathyroid
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39. Weber T, Cammerer G, Schick C, Solbach C, Hillenbrand A, Barth TF, Henne-Bruns D, Blagieva R, Böhm BO, Reske SN, Luster M: C-11 methionine positron emission tomography/computed tomography localizes parathyroid adenomas in primary hyperparathyroidism. Horm Metab Res; 2010 Mar;42(3):209-14
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  • [Title] C-11 methionine positron emission tomography/computed tomography localizes parathyroid adenomas in primary hyperparathyroidism.
  • In patients with primary hyperparathyroidism (pHPT), positive preoperative localization studies enable to perform a minimally invasive approach for parathyroid surgery.
  • We therefore conducted a study to determine the sensitivity of C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) in localizing parathyroid adenomas in pHPT.
  • Met-PET/CT scans of the neck and mediastinum of 33 patients undergoing parathyroidectomy for primary HPT were compared with intraoperative and histological findings.
  • Primary HPT was caused by a single gland adenoma in 30 patients, while another 3 patients had multiglandular disease.
  • Met-PET/CT scan correctly located a single gland adenoma in 25 out of 30 (83%) patients with pHPT, among them 2 patients with persistent disease, 7 patients with prior neck surgery, and 8 patients with concomitant thyroid nodules.
  • In 3 patients with multiglandular disease, Met-PET/CT showed only one enlarged parathyroid gland in two individuals and was negative in the third patient.
  • Statistical analysis found a significant correlation between true-positive results and the weight (2.42+/-4.05 g) and diameter (2.0+/-1.18 cm) of parathyroid adenomas while the subgroup with false negative findings had significantly smaller (0.98+/-0.54 cm) and lighter (0.5+/-0.38 g) glands.
  • Sensitivity was 83% for single gland adenomas and 67% for multiglandular disease.
  • Met-PET/CT correctly localized 83% of single gland parathyroid adenomas in patients with pHPT.
  • However, preoperative localization of multiglandular disease due to double adenomas or parathyroid hyperplasia remained difficult.
  • [MeSH-major] Adenoma / radionuclide imaging. Hyperparathyroidism, Primary / radionuclide imaging. Methionine. Parathyroid Neoplasms / radionuclide imaging. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20013649.001).
  • [ISSN] 1439-4286
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 58576-49-1 / carbon-11 methionine; AE28F7PNPL / Methionine
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40. Calzolari F, Misso C, D'Ajello M, Monacelli M, Iapadre M, Sanguinetti A, Lucchini R, Di Carlo L, Semeraro A, Sciamannini M, Avenia N: [Role of minimally invasive surgery in the treatment of primary hyperparathyroidism]. Chir Ital; 2006 May-Jun;58(3):331-5
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  • [Title] [Role of minimally invasive surgery in the treatment of primary hyperparathyroidism].
  • The minimally invasive approach to parathyroid surgery is considered an efficient alternative to traditional cervicotomy when the pre-operative diagnostic work-up indicates a single parathyroid adenoma.
  • Imaging techniques (ultrasound, SPECT), on the one hand, and intraoperative diagnostic techniques (radio-guided surgery, intraoperative parathyroid hormone assay), on the other, contribute to the success and development of specialized centres which prefer to use this type of surgery.
  • [MeSH-major] Hyperparathyroidism, Primary / surgery. Parathyroidectomy / methods

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  • (PMID = 16845870.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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41. Agarwal AM, Bentz JS, Hungerford R, Abraham D: Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients. Diagn Cytopathol; 2009 Jun;37(6):407-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients.
  • This study was designed to assess the utility of fine-needle aspiration cytology (FNAC) in the preoperative localization of parathyroid adenoma (PA).
  • Parathyroid hormone (PTH) estimation was performed on the supernatant of the aspirated fluid on all cases.
  • Parathyroid cells were seen in 23 samples (40.4%).
  • Majority of the samples with parathyroid cells showed moderate cellularity with monomorphous round to slightly oval cells predominantly arranged in loose two-dimensional clusters with occasional papillary fragments.
  • In conclusion, US-guided FNAC has its limitations because of low sensitivity in primary localization of the parathyroid adenoma in cases of primary hyperparathyroidism and is not a useful mode of investigation in cases of PA.
  • [MeSH-major] Parathyroid Glands / pathology. Parathyroid Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19283690.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromatin
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42. Su AW, Chen CF, Huang CK, Chen PC, Chen WM, Chen TH: Primary hyperparathyroidism with brown tumor mimicking metastatic bone malignancy. J Chin Med Assoc; 2010 Mar;73(3):177-80
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  • [Title] Primary hyperparathyroidism with brown tumor mimicking metastatic bone malignancy.
  • We report a case of brown tumor caused by parathyroid adenoma.
  • With a systematic approach and awareness of metabolic bone disease, an accurate diagnosis was finally reached.
  • Appropriate treatments, including preventive internal fixation of the impending femoral fracture and surgical excision of the parathyroid adenoma were performed accordingly.
  • The key treatment for the condition was surgical excision of the parathyroid adenoma.
  • After normalization of serum intact-parathyroid hormone level, the bony lesions resolved and required no further orthopedic surgery.
  • [MeSH-major] Bone Neoplasms / diagnosis. Hyperparathyroidism, Primary / complications. Osteitis Fibrosa Cystica / diagnosis
  • [MeSH-minor] Adenoma / complications. Aged. Diagnosis, Differential. Humans. Male. Parathyroid Neoplasms / complications

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  • [Copyright] Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20231005.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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43. Costanzo M, Terminella A, Marziani A, Chisari A, Missiato A, Cannizzaro MA: Giant mediastinal parathyroid adenoma: a case report. Ann Ital Chir; 2009 Jan-Feb;80(1):55-9
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  • [Title] Giant mediastinal parathyroid adenoma: a case report.
  • Neck and chest TC and 'TC sestamibi scintigraphy showed the presence of a 7 cm hyperfunctional ectopic parathyroid tissue in the postero-superior mediastinum infiltrating oesophagus.
  • Through right postero-lateral thoracotomy and mediastinal pleura incision, the adenoma excision was carried out.
  • The histological examination revealed a potentially malignant parathyroid adenoma with infiltration, without over-reaching the capsule.
  • Today, the tendency to minimally invasive surgery, an accurate preoperative localization of the adenoma and the use of techniques such as intra-surgical nuclear mapping through manual gamma probes, selective angiography, venous intraoperative dosage of PTH and intra-surgical ultrasound scan.
  • [MeSH-major] Adenocarcinoma / pathology. Choristoma / pathology. Mediastinum / pathology. Parathyroid Glands. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Aged. Female. Humans. Parathyroidectomy. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Treatment Outcome

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  • (PMID = 19537125.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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44. Moore FD Jr: Are scintigraphy, ultrasonography, and the parathyroid hormone assay necessary to identify solitary parathyroid adenomas? Nat Clin Pract Endocrinol Metab; 2007 Mar;3(3):214-5
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  • [Title] Are scintigraphy, ultrasonography, and the parathyroid hormone assay necessary to identify solitary parathyroid adenomas?

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  • [CommentOn] Clin Endocrinol (Oxf). 2006 Jul;65(1):106-13 [16817828.001]
  • (PMID = 17262065.001).
  • [ISSN] 1745-8366
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
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45. Liu Y, Chun KJ, Freeman LM: 'Shine through' on dual tracer parathyroid scintigraphy: a potential pitfall in interpretation. Clin Nucl Med; 2005 Mar;30(3):145-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 'Shine through' on dual tracer parathyroid scintigraphy: a potential pitfall in interpretation.
  • Dual tracer scintigraphy has become the procedure of choice for preoperative localization of parathyroid adenomas.
  • To differentiate a parathyroid adenoma from a thyroid adenoma, it may be necessary to repeat the thyroid-specific pertechnetate scan on a separate day after the dual tracer study.
  • [MeSH-major] Adenoma / radionuclide imaging. Artifacts. Diagnostic Errors / prevention & control. Image Enhancement / methods. Parathyroid Neoplasms / radionuclide imaging. Sodium Pertechnetate Tc 99m. Technetium Tc 99m Sestamibi. Thyroid Neoplasms / radionuclide imaging
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Middle Aged. Radiopharmaceuticals

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  • (PMID = 15722816.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi; A0730CX801 / Sodium Pertechnetate Tc 99m
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46. Nwariaku FE, Snyder WH, Burkey SH, Watumull L, Mathews D: Inframanubrial parathyroid glands in patients with primary hyperparathyroidism: alternatives to sternotomy. World J Surg; 2005 Apr;29(4):491-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inframanubrial parathyroid glands in patients with primary hyperparathyroidism: alternatives to sternotomy.
  • Deep inframanubrial parathyroid tumors have traditionally been excised through a median sternotomy.
  • With the advent of minimally invasive surgical access, we chose to examine the treatment options and outcomes of patients with inframanubrial mediastinal parathyroid tumors.
  • Patients with primary hyperparathyroidism seen at a university medical center over a 12-year period were retrospectively reviewed.
  • The utility of localization studies, methods of treatment, complications, and outcomes were examined in patients with a parathyroid tumor located in the mediastinum inferior to the manubrium.
  • Patients with parathyroid adenomas located at the thoracic inlet were excluded.
  • Altogether, 81% of the patients had undergone at least one prior neck exploration for primary hyperparathyroidism.
  • Preoperative calcium and parathyroid hormone levels were 12.4 +/- 0.36 mg/dl and 273 +/- 70 pg/ml, respectively.
  • Localization studies identified mediastinal parathyroid adenomas in the following locations: anterior mediastinum (n = 8), middle mediastinum (n = 7), posterior mediastinum (n = 1).
  • Seven patients underwent successful excision of the mediastinal adenoma by transcervical mediastinal exploration with the Cooper retractor.
  • Most inframanubrial mediastinal parathyroid tumors can be successfully managed without median sternotomy.
  • [MeSH-major] Parathyroid Neoplasms / surgery. Sternum / surgery
  • [MeSH-minor] Adenoma / surgery. Adolescent. Adult. Aged. Calcium / blood. Female. Humans. Hyperparathyroidism / surgery. Magnetic Resonance Imaging. Male. Mediastinum. Middle Aged. Minimally Invasive Surgical Procedures. Parathyroid Hormone / blood. Radiopharmaceuticals. Retrospective Studies. Sensitivity and Specificity. Technetium Tc 99m Sestamibi. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed

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  • (PMID = 15770373.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi; SY7Q814VUP / Calcium
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47. Richard B: [Primary hyperparathyroidism: ultrasonography and scintigraphy]. J Radiol; 2009 Mar;90(3 Pt 2):397-408
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  • [Title] [Primary hyperparathyroidism: ultrasonography and scintigraphy].
  • Primary hyperparathyroidism is nowadays frequently diagnosed from screening biological work-up: it is due to a single parathyroid adenoma in nearly 90% of cases.
  • Ultrasound offers detailed anatomic imaging of the adenoma but may not be not able to detect some ectopic glands.
  • Radionuclide scanning using Tc-99m-Sestamibi is able to localize parathyroid adenomas even in the case of ectopic localization with the help of SPECT-CT.
  • [MeSH-major] Adenoma / radionuclide imaging. Adenoma / ultrasonography. Hyperparathyroidism, Primary / radionuclide imaging. Hyperparathyroidism, Primary / ultrasonography. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / ultrasonography. Radionuclide Imaging / methods. Ultrasonography / methods

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  • (PMID = 19421130.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  • [Number-of-references] 4
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48. Carchman E, Ogilvie J, Holst J, Yim J, Carty S: Appropriate surgical treatment of lithium-associated hyperparathyroidism. World J Surg; 2008 Oct;32(10):2195-9
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  • [Title] Appropriate surgical treatment of lithium-associated hyperparathyroidism.
  • Although lithium-associated hyperparathyroidism (LAH) is well documented, reports concerning its pathologic findings are sparse.
  • METHODS: From 1995 to 2007, data from 1207 consecutive patients who underwent concise parathyroid exploration for sporadic primary hyperparathyroidism (PHP) directed by quick intraoperative parathyroid hormone monitoring (QPTH) were reviewed to identify patients with LAH.
  • Among 16 patients with LAH, 12 (75%) had a single adenoma.
  • The use of QPTH allowed unilateral exploration in 8 of 12 patients with single adenoma.
  • Parathyroid exploration resulted in durable biochemical cure for all 16 patients with LAH.
  • CONCLUSION: Multiglandular disease seems to be no more frequent in patients with LAH than in patients with primary hyperparathyroidism (PHP) without LAH.
  • [MeSH-major] Antimanic Agents / adverse effects. Hyperparathyroidism / surgery. Lithium Compounds / adverse effects. Parathyroidectomy / methods
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / surgery. Bipolar Disorder / drug therapy. Female. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Parathyroid Hormone / blood. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / surgery. Preoperative Care / methods. Prospective Studies. Recurrence. Retrospective Studies. Treatment Outcome

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  • (PMID = 18463919.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimanic Agents; 0 / Lithium Compounds; 0 / Parathyroid Hormone
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49. Giraldez-Rodriguez LA, Giraldez-Casasnovas LJ: Minimally invasive parathyroidectomy as treatment for primary hyperparathyroidism. Bol Asoc Med P R; 2008 Jan-Mar;100(1):27-32
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  • [Title] Minimally invasive parathyroidectomy as treatment for primary hyperparathyroidism.
  • BACKGROUND: Current techniques for management of primary hyperpara-thyroidism (pHPT) rely on preoperative localization studies in order to perform a direct exploration of the neck.
  • This case series reports the results of minimally invasive parathyroidectomy (MIP) performed in twenty-two consecutive pHPT patients with suspected parathyroid adenoma.
  • METHODS: All patients with symptomatic pHPT and or aberrant biochemical markers underwent preoperative evaluation including calcium and parathyroid hormone (PTH) serum levels, and a Tc-99 Sestamibi (MIBI) scintigraphy scan.
  • The day of surgery Tc-99 MIBI was administered intravenously to localize diseased parathyroid glands.
  • All removed tissue was again tested with the gamma radiation probe and sent for frozen sections to confirm parathyroid gland tissue.
  • Parathyroid adenoma was confirmed by frozen sections in all patients.
  • CONCLUSIONS: MIP using preoperative Tc-99 MIBI scan is an excellent and safe treatment for patients in pHPT patients with a suspected parathyroid adenoma.
  • [MeSH-major] Hyperparathyroidism, Primary / surgery. Parathyroidectomy / methods

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  • (PMID = 18763394.001).
  • [ISSN] 0004-4849
  • [Journal-full-title] Boletín de la Asociación Médica de Puerto Rico
  • [ISO-abbreviation] Bol Asoc Med P R
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Puerto Rico
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50. Ostojić Z, Grle M, Moro G, Zubak Z, Ostojić M: Bone fractures in a 53-year-old patient with parathyroid adenoma--a case report. Coll Antropol; 2010 Mar;34 Suppl 1:295-8
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  • [Title] Bone fractures in a 53-year-old patient with parathyroid adenoma--a case report.
  • The study reports a case of primary hyperparathyroidism in a middle-aged patient who was first admitted for persistent ankle pain and local swelling.
  • The subsequent clinical procedures suggested cystic changes in several leg bones, which were later shown to be caused by the parathyroid adenoma.
  • Clinical presentation of the primary hyperparathyroidism can be highly misleading, sometimes causing various clinical procedures before it is certainly diagnosed.
  • [MeSH-major] Adenoma / complications. Femoral Fractures / etiology. Hyperparathyroidism, Primary / diagnosis. Parathyroid Neoplasms / complications. Tibial Fractures / etiology

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  • (PMID = 20402337.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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51. Ismail M, Maza S, Swierzy M, Tsilimparis N, Rogalla P, Sandrock D, Rückert RI, Müller JM, Rückert JC: Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic system. Br J Surg; 2010 Mar;97(3):337-43
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  • [Title] Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic system.
  • BACKGROUND: Mediastinal ectopic parathyroid adenoma is a frequent cause of persistent or recurrent hyperparathyroidism, traditionally treated by open surgery.
  • The aim of this study was to evaluate the feasibility and effectiveness of robot-assisted dissection for mediastinal ectopic parathyroid glands.
  • METHODS: Two patients with recurrent secondary hyperparathyroidism and three with complicated primary hyperparathyroidism were operated on between July 2004 and August 2008 for ectopic mediastinal parathyroid glands.
  • Intraoperative parathyroid hormone reduction indicated complete resection.
  • CONCLUSION: Robot-assisted dissection is a promising approach for resection of ectopic parathyroid glands in remote narrow anatomical locations such as the mediastinum.
  • [MeSH-major] Adenoma / surgery. Mediastinal Neoplasms / surgery. Parathyroid Glands / surgery. Parathyroid Neoplasms / surgery. Robotics

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  • [Copyright] (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 20095017.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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52. Ahmad S, Mufti TS, Khan AA, Ahmad S: Parathyroid carcinoma. J Ayub Med Coll Abbottabad; 2006 Apr-Jun;18(2):84-5
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  • [Title] Parathyroid carcinoma.
  • Parathyroid carcinoma is a very rare cause of primary hyperparathyroidism and these tumors are usually hyper-functioning as compared to other malignant endocrine tumors.
  • Surgery is the only effective primary treatment.
  • Parathyroid adenoma was initially diagnosed and localized at left lower gland by Sestamibi scan and ultrasonography.
  • She underwent surgery and enlarged parathyroid gland was removed.
  • [MeSH-major] Adenoma / diagnosis. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16977824.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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53. Fanthome B, Bharadwaj R, Suryanarayana KM: Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience. Med J Armed Forces India; 2006 Oct;62(4):312-5
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  • [Title] Parathyroid Neoplasms: The Army Hospital (Research & Referral) Experience.
  • BACKGROUND: Neoplasms of the parathyroid are common but parathyroid carcinoma is exceptionally rare.
  • In contrast to most other malignant endocrine tumours that are usually less hormonally active, malignant parathyroid tumours are hyper functional.
  • Malignant parathyroid tumours pose a diagnostic dilemma for the pathologist.
  • OBJECTIVE: To study the clinicopathological profile of a case series of parathyroid neoplasms and determine features which facilitate a malignant diagnosis.
  • METHODS: A retrospective analysis of seven cases of surgically treated parathyroid tumours over a three-year period at a single centre was done.
  • Thick fibrous capsule and broad septal fibrosis was seen in both the carcinomas; these were thin in the adenomas.
  • CONCLUSION: Elevated serum calcium and parathormone values point to a parathyroid neoplasm.

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  • (PMID = 27688529.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Keywords] NOTNLM ; Adenoma / Carcinoma / Parathyroid
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54. Ohe MN, Santos RO, Kunii IS, Abrahão M, Cervantes O, Carvalho AB, Lazaretti-Castro M, Vieira JG: [Usefulness of intraoperative PTH measurement in primary and secondary hyperparathyroidism: experience with 109 patients]. Arq Bras Endocrinol Metabol; 2006 Oct;50(5):869-75
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  • [Title] [Usefulness of intraoperative PTH measurement in primary and secondary hyperparathyroidism: experience with 109 patients].
  • [Transliterated title] Utilidade da medida de PTH intra-operatório no tratamento cirúrgico do hiperparatiroidismo primário e secundário: análise de 109 casos.
  • INTRODUCTION: Intraoperative parathyroid hormone measurement (IO-PTH) was first described in 1988 and it's potentially useful in predicting cure after parathyroidectomy.
  • The aim of this study was to evaluate IO-PTH decay profile and the utility of this procedure in predicting cure in primary (PHH) and secondary (SHH) hyperparathyroidism due to renal disease.
  • All patients were cured, except 2 (1 PHH, 1 SHH), because of a double adenoma and ectopic (mediastinal) parathyroid respectively.
  • [MeSH-major] Hyperparathyroidism, Primary / blood. Hyperparathyroidism, Secondary / blood. Monitoring, Intraoperative. Parathyroid Hormone / blood. Parathyroidectomy

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  • (PMID = 17160210.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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55. Berland T, Smith SL, Huguet KL: Occult fifth gland intrathyroid parathyroid adenoma identified by gamma probe. Am Surg; 2005 Mar;71(3):264-6
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  • [Title] Occult fifth gland intrathyroid parathyroid adenoma identified by gamma probe.
  • The gamma probe was instrumental in guiding us to the adenoma in a fifth gland that was not visible and was localized to the parenchyma of the left lobe of the thyroid gland.
  • Many surgeons do not advocate use of the gamma probe in minimally invasive parathyroidectomy and rely solely on focused exploration on the basis of a preoperative sestamibi scan and intraoperative rapid parathyroid hormone assays.
  • This case, however, illustrates the utility of the gamma probe in parathyroid adenoma localization.
  • [MeSH-major] Adenoma / radionuclide imaging. Adenoma / surgery. Parathyroid Glands / abnormalities. Parathyroid Neoplasms / radionuclide imaging. Technetium Tc 99m Sestamibi
  • [MeSH-minor] Female. Follow-Up Studies. Gamma Cameras. Humans. Hyperparathyroidism / diagnosis. Hyperparathyroidism / etiology. Middle Aged. Minimally Invasive Surgical Procedures / instrumentation. Parathyroidectomy / methods. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 15869146.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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56. Derreberry T, Yaqub A: Parathyroid FNA and hormone assay. W V Med J; 2009 Sep-Oct;105(5):30-4
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  • [Title] Parathyroid FNA and hormone assay.
  • Primary hyperparathyroidism is a relatively common problem encountered in clinical endocrine practice.
  • In most cases the diagnosis is relatively straightforward, however, when imaging studies fail to localize the parathyroid adenoma or hyperplasia, management can be challenging.
  • We describe here such a case where the diagnosis was made by a novel method of analysis of parathyroid hormone levels in the needle wash obtained during fine-needle aspiration of a suspected parathyroid adenoma.
  • His parathyroid hormone level was within normal limits.
  • He was started on hydrochlorthiazide therapy for a presumptive diagnosis of idiopathic hypercalciuria.
  • Parathyroid hormone level remained in mid-normal range.
  • A diagnosis of primary hyperparathyroidism was considered at this stage and imaging studies were carried out to localize the parathyroid pathology.
  • Parathyroid-sestamibi scan did not reveal any abnormality.
  • A fine needle aspiration of the nodule was carried out with estimation of parathyroid hormone level in the needle wash to indicate the presence of parathyroid adenoma.
  • The current management of hyperparathyroidism is primarily surgical.
  • Minimally invasive parathyroid surgery is the treatment of choice but it requires the clear localization of a parathyroid lesion for successful removal.
  • In cases where preoperative localization is evasive, novel techniques, such as the one described above, can provide useful diagnostic information which can aid in the successful management of hyperparathyroidism.
  • [MeSH-major] Adenoma / pathology. Parathyroid Hormone / analysis. Parathyroid Neoplasms / pathology

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  • (PMID = 19806869.001).
  • [ISSN] 0043-3284
  • [Journal-full-title] The West Virginia medical journal
  • [ISO-abbreviation] W V Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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57. Raghay K, García-Caballero T, Nogueiras R, Morel G, Beiras A, Diéguez C, Gallego R: Ghrelin localization in rat and human thyroid and parathyroid glands and tumours. Histochem Cell Biol; 2006 Mar;125(3):239-46
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  • [Title] Ghrelin localization in rat and human thyroid and parathyroid glands and tumours.
  • In the current study, we use molecular biology to detect ghrelin transcripts expression in rats, and immunohistochemical techniques to investigate the cellular distribution of this peptide in rat and human thyroid and parathyroid glands and tumours.
  • Ghrelin was localized in thyroid C cells and in parathyroid cells.
  • Thyroid carcinomas (medullar, follicular and papillary) and parathyroid adenomas also showed intense and diffuse immunostaining for ghrelin.
  • The diffuse ghrelin immunostaining found in the parathyroid gland opens up the possibility of its secretion to the bloodstream or its involvement in the regulation of the parathyroid function.
  • Overall, expression of ghrelin in human and rat thyroid and parathyroid glands is highly suggestive of a conserved role of this molecule in the regulation of thyroid and parathyroid cell function.
  • [MeSH-major] Parathyroid Glands / metabolism. Parathyroid Neoplasms / metabolism. Peptide Hormones / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 16187069.001).
  • [ISSN] 0948-6143
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Ghrelin; 0 / Peptide Hormones; 0 / RNA, Messenger
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58. Târcoveanu E, Niculescu D, Cotea E, Moldovanu R, Vasilescu A, Crumpei F, Zbranca E, Zugun F, Rusu V, Ferariu D: [Parathyroid glands involvement in multiple endocrine neoplasia]. Rev Med Chir Soc Med Nat Iasi; 2009 Apr-Jun;113(2):482-96
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  • [Title] [Parathyroid glands involvement in multiple endocrine neoplasia].
  • Parathyroid gland involvement is usually noted in Multiple Endocrine Neoplasia (MEN) type I and type II.
  • Parathyroid glands tumor associated with endocrine pancreatic tumor, as well as pituitary tumors is the typical pattern of MEN I.
  • The parathyroid gland is the most frequent abnormality in MEN I.
  • CASES REPORTS: We presented five cases with MEN I and parathyroid glands involvement.
  • In three cases with young ages (28-33 years old) and familial setting, the MEN I syndrome was "complete" (parathyroid adenoma, gastrinoma or insulinoma and pituitary adenoma--prolactinoma or GH-secreting tumors), and, in the other two cases, with 57 and 68 years old respectively, the MEN I syndrome was "incomplete" with parathyroid glands and pituitary gland involvement.
  • Unfortunately one patients died due to severe endocrine disorder.
  • During the necropsy, the pituitary adenoma has been diagnosed.
  • The imagistic and laboratory test diagnosed a tumor situated into the pancreatic body, and an parathyroid adenoma.
  • The resection of pancreatic tumor associated with resection of the parathyroid adenoma, in the same time, were performed.
  • The other two cases with "incomplete" MEN were older then the first patients, and were diagnosed with hyperparathyrodism and pituitary gland tumor.
  • The resection of parathyroid gland adenoma has been performed in both cases, with uneventful postoperative course.
  • CONCLUSIONS: The parathyroid glands involvement in MEN is common.
  • There are two kinds of MEN associated with parathyroid gland involvement: the "complete" form, especially in young patients, with diffuse involvement of the parathyroid glands, and the subtotal parathyroidy is the best choice, and the "incomplete" form, especially in elderly, with the involvement of a single parathyroid gland; in this way, the resection of the adenoma associated with biopsy from the other parathyroid gland is the best approach.
  • [MeSH-major] Adenoma / surgery. Gastrinoma / surgery. Insulinoma / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy
  • [MeSH-minor] Adult. Aged. Fatal Outcome. Female. Humans. Hyperparathyroidism, Secondary / diagnosis. Hyperparathyroidism, Secondary / etiology. Male. Middle Aged. Multiple Endocrine Neoplasia / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery. Prolactinoma / diagnosis. Prolactinoma / surgery. Treatment Outcome

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  • (PMID = 21495355.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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59. Oh SY, Kim S, Eskandar Y, Kim DW, Krynyckyi BR, Machac J, Inabnet WB 3rd, Kim CK: Appearance of intrathymic parathyroid adenomas on pinhole sestamibi parathyroid imaging. Clin Nucl Med; 2006 Jun;31(6):325-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appearance of intrathymic parathyroid adenomas on pinhole sestamibi parathyroid imaging.
  • OBJECTIVES: Ectopic inferior parathyroid adenomas (PAs) are frequently located in the anterior mediastinum, quite often in the thymus gland.
  • Clinical follow up has shown that most intrathymic adenomas were visualized on pinhole views and located closer to the thyroid than expected.
  • METHODS: We retrospectively reviewed sestamibi pinhole parathyroid imaging performed on 163 patients with primary hyperparathyroidism and final diagnoses established by surgery, histology, intraoperative PTH monitoring, and clinical follow up.
  • Of the 93 foci in group A, there were 80 normally situated inferior PA, 6 descended superior PA, 3 intrathyroidal PA, one hyperplastic parathyroid gland, one thyroid adenoma, one unidentified, and one intrathymic PA.
  • CONCLUSION: Focal increased activity completely separated from the lower pole of thyroid (regardless of the distance of separation) on sestamibi pinhole images indicates a high probability of intrathymic parathyroid adenoma.
  • [MeSH-major] Adenoma / radionuclide imaging. Parathyroid Neoplasms / radionuclide imaging. Technetium Tc 99m Sestamibi. Thymus Neoplasms / radionuclide imaging. Thymus Neoplasms / secondary. Tomography, Emission-Computed, Single-Photon / methods

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  • (PMID = 16714889.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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60. Huang SC, Wu VC, Chou G, Huang TY, Lin SY, Sheu WH: Benign parathyroid adenoma presenting with unusual parathyroid crisis, anemia and myelofibrosis. J Formos Med Assoc; 2007 Feb;106(2 Suppl):S13-6
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  • [Title] Benign parathyroid adenoma presenting with unusual parathyroid crisis, anemia and myelofibrosis.
  • Although the clinical symptoms of patients with benign parathyroid adenoma are usually nonspecific and benign, a malignant presentation of the benign disease may sometimes occur.
  • Acute hypercalcemic crisis manifested and primary hyperparathyroidism was diagnosed together with myelofibrosis on account of the result of bone marrow biopsy.
  • Excision of a parathyroid adenoma was performed, and the anemia and bone marker regressed later.
  • These findings suggested that benign parathyroid adenoma may mimic the clinical presentation of parathyroid carcinoma, releasing excess parathyroid hormone and resulting in hyperparathyroid crisis.
  • In addition, primary hyperparathyroidism can be associated with anemia and myelofibrosis.

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  • (PMID = 17493890.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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61. Corbetta S, Vaira V, Guarnieri V, Scillitani A, Eller-Vainicher C, Ferrero S, Vicentini L, Chiodini I, Bisceglia M, Beck-Peccoz P, Bosari S, Spada A: Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue. Endocr Relat Cancer; 2010 Mar;17(1):135-46
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  • [Title] Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue.
  • Parathyroid carcinoma (PaC) is a rare cause of primary hyperparathyroidism.
  • Though the loss of the oncosuppressor CDC73/HRPT2 gene product, parafibromin, has been involved in the hyperparathyroidism-jaw tumor syndrome and in a consistent set of sporadic PaCs, parathyroid carcinogenesis remains obscure.
  • The aim of the present study was to identify differentially expressed microRNAs in parathyroid cancers compared with normal tissues.
  • We performed a TaqMan low-density array profiling of four parathyroid cancers harboring CDC73 inactivating mutations and negative for parafibromin immunostaining.
  • Their microRNA profiling was compared with that of two normal parathyroid biopsies.
  • Fourteen and three microRNAs were significantly down- and over-expressed in parathyroid cancers respectively.
  • Carcinomas could be discriminated from parathyroid adenomas by a computed score based on the expression levels of miR-296, miR-222, and miR-503 as miR-139 was similarly down-regulated in both cancers and adenomas.
  • [MeSH-major] Adenoma / genetics. Carcinoma / genetics. MicroRNAs / genetics. Parathyroid Glands / metabolism. Parathyroid Neoplasms / genetics

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  • (PMID = 19926710.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MIRN296 microRNA, human; 0 / MicroRNAs
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62. Eloy JA, Mitty H, Genden EM: Preoperative selective venous sampling for nonlocalizing parathyroid adenomas. Thyroid; 2006 Aug;16(8):787-90
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  • [Title] Preoperative selective venous sampling for nonlocalizing parathyroid adenomas.
  • INTRODUCTION: Preoperative parathyroid adenoma localization allows for a minimally invasive surgical approach.
  • Current methods used for adenoma localization include ultrasound, sestamibi scan, and occasionally magnetic resonance imaging (MRI).
  • In cases in which an adenoma is not localized after a radiologic work-up, the surgeon must perform a four-gland exploration.
  • Preoperative selective venous sampling (SVS) has been described as a safe and clinically effective method to localize a parathyroid adenoma after failed exploration.
  • The purpose of this study was to evaluate the efficacy of SVS as a primary localization technique in cases where conventional localization techniques have failed.
  • MATERIALS AND METHODS: Fourteen patients with nonlocalizing parathyroid adenomas after ultrasonography, sestamibi scanning, and MRI were retrospectively reviewed.
  • Eight patients underwent SVS prior to surgery and six patients underwent a four-gland neck exploration without preoperative Svs. The two groups were assessed for accuracy of the SVS in localizing the adenoma, operative time, length of hospitalization, and complications.
  • The SVS proved accurate in preoperatively localizing the adenoma in 7 of 8 patients and allowed for a minimally invasive approach in 87% of patients.
  • CONCLUSION: This study suggests that preoperative SVS may represent a safe and effective method of preoperatively localizing the nonlocalized parathyroid adenoma.
  • In cases where conventional radiologic techniques fail to localize an adenoma, SVS may obviate the need for a four-gland exploration.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Parathyroid Neoplasms / pathology. Parathyroid Neoplasms / radionuclide imaging. Technetium Tc 99m Sestamibi

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  • (PMID = 16910882.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
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63. Kinoshita Y, Taguchi M, Takeshita A, Miura D, Tomikawa S, Takeuchi Y: 1,25-dihydroxyvitamin D suppresses circulating levels of parathyroid hormone in a patient with primary hyperparathyroidism and coexistent sarcoidosis. J Clin Endocrinol Metab; 2005 Dec;90(12):6727-31
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  • [Title] 1,25-dihydroxyvitamin D suppresses circulating levels of parathyroid hormone in a patient with primary hyperparathyroidism and coexistent sarcoidosis.
  • CONTEXT: PTH is excessively secreted to develop hypercalcemia and accelerate bone turnover in patients with primary hyperparathyroidism.
  • PTH stimulates the production of 1,25-dihydroxyvitamin D [1,25(OH)2D] that in turn suppresses the synthesis of PTH in parathyroid cells.
  • OBJECTIVE: The objective of the study was to clarify whether 1,25(OH)2D indeed inhibits circulating levels of PTH and influences bone turnover, even in a patient with primary hyperparathyroidism.
  • DESIGN, SETTING, AND PATIENT: We evaluated PTH levels in a patient with primary hyperparathyroidism and coexistent sarcoidosis whose serum 1,25(OH)2D levels were independent of PTH.
  • INTERVENTIONS AND MAIN OUTCOME MEASURES: The present case was treated with prednisolone before and after surgical resection of parathyroid adenoma, and Ca-regulating hormones and bone markers were measured.
  • RESULTS: Serum Ca and PTH levels significantly decreased after parathyroid surgery, whereas serum 1,25(OH)2D levels remained high.
  • Urine N-telopeptides, serum osteocalcin, and bone-type alkaline phosphatase all decreased to physiological ranges after parathyroid surgery.
  • CONCLUSIONS: These results suggest that 1,25(OH)2D indeed inhibits the production of PTH not to exacerbate hypercalcemia in a patient with primary hyperparathyroidism.
  • [MeSH-major] Hyperparathyroidism, Primary / complications. Hyperparathyroidism, Primary / metabolism. Parathyroid Hormone / antagonists & inhibitors. Parathyroid Hormone / blood. Sarcoidosis / complications. Vitamin D / analogs & derivatives


64. Bohrer T, Krannich JH: Depression as a manifestation of latent chronic hypoparathyroidism. World J Biol Psychiatry; 2007;8(1):56-9
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  • We report the first case of an elderly patient with a long history of major depression as a complication of an undiagnosed chronic hypoparathyroidism following surgery on a parathyroid adenoma.
  • As it is well known that disturbances in the endocrine hypothalamus-pituitary-thyroid system might be consistent findings of depressive disorders concerning neuroendocrinological alterations, this case report and review of literature strongly supports our claim that also parathyroid diseases like chronic hypoparathyroidism, even in its latent form, might be a relevant factor in the development of depressive symptoms.
  • [MeSH-major] Adenoma / surgery. Depressive Disorder, Major / diagnosis. Depressive Disorder, Major / etiology. Hyperparathyroidism, Primary / surgery. Hypoparathyroidism / complications. Hypoparathyroidism / diagnosis. Parathyroid Neoplasms / surgery. Parathyroidectomy. Postoperative Complications / diagnosis
  • [MeSH-minor] Aged. Antidepressive Agents / therapeutic use. Diagnosis, Differential. Drug Therapy, Combination. Female. Humans. Hypocalcemia / diagnosis. Hypocalcemia / etiology. Hypocalcemia / psychology. Treatment Failure

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  • (PMID = 17366354.001).
  • [ISSN] 1562-2975
  • [Journal-full-title] The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • [ISO-abbreviation] World J. Biol. Psychiatry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antidepressive Agents
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65. Liu PT, Johnson CD, Miranda R, Patel MD, Phillips CJ: A reference standard-based quality assurance program for radiology. J Am Coll Radiol; 2010 Jan;7(1):61-6
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  • The performance metrics tracked by the QA program include the accuracy of CT colonography for detecting polyps, the false-negative rate for mammographic detection of breast cancer, the accuracy of CT angiography detection of coronary artery stenosis, the accuracy of meniscal tear detection on MRI, the accuracy of carotid artery stenosis detection on MR angiography, the accuracy of parathyroid adenoma detection by parathyroid scintigraphy, the success rate for obtaining cortical tissue on ultrasound-guided core biopsies of pelvic renal transplants, and the technical success rate for peripheral arterial angioplasty procedures.

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  • [Copyright] Copyright 2010 American College of Radiology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20129274.001).
  • [ISSN] 1558-349X
  • [Journal-full-title] Journal of the American College of Radiology : JACR
  • [ISO-abbreviation] J Am Coll Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Wasty SW, Iqbal K, Beg MR, Mahida KH, Ali G, Tariq M: Giant cell tumours of the maxilla and tibia presenting concurrently as an initial manifestation of primary parathyroid adenoma. J Pak Med Assoc; 2005 Apr;55(4):170-2
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  • [Title] Giant cell tumours of the maxilla and tibia presenting concurrently as an initial manifestation of primary parathyroid adenoma.
  • Serum calcium was normal, but the parathyroid hormone was exaggerated (678 pg/ml).
  • Ultrasound indicated and Tc-99m Setamibi scan confirmed a left lower parathyroid lesion.
  • A 4cm length mass was identified, removed and proved to be a parathyroid adenoma.
  • Serum parathyroid hormone level normalized.
  • [MeSH-major] Adenoma / pathology. Giant Cell Tumor of Bone / etiology. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Calcium / blood. Female. Humans. Maxilla / pathology. Maxilla / surgery. Parathyroid Glands / pathology. Parathyroid Glands / surgery. Tibia / pathology. Tibia / surgery. Treatment Outcome

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  • (PMID = 15918632.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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67. Yener S, Saklamaz A, Demir T, Kebapcilar L, Bayraktar F, Canda S, Yesil S: Primary hyperparathyroidism due to atypical parathyroid adenoma presenting with peroneus brevis tendon rupture. J Endocrinol Invest; 2007 May;30(5):442-4
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  • [Title] Primary hyperparathyroidism due to atypical parathyroid adenoma presenting with peroneus brevis tendon rupture.
  • [MeSH-major] Adenoma / complications. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Tendon Injuries / etiology

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  • (PMID = 17598980.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Italy
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68. Jódar Gimeno E: [Consensus and clinical practice guidelines in primary hyperparathyroidism]. Endocrinol Nutr; 2009 Apr;56 Suppl 1:41-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Consensus and clinical practice guidelines in primary hyperparathyroidism].
  • [Transliterated title] Consensos y guías de práctica clínica en hiperparatiroidismo primario.
  • Primary hyperparathyroidism (PHPT) is a disease whose form of presentation, diagnosis and treatment recommendations have been substantially modified in the last few years.
  • If surgery is indicated, parathyroid scintigraphy and other localization techniques help to identify patients with a single adenoma who can undergo a minimally invasive approach under local anesthesia, as well as those with parathyroid tissue remnants undergoing reintervention due to persistent or recurrent PHPT.
  • Intraoperative parathyroid hormone determination seems to be valid in these situations.
  • [MeSH-major] Consensus Development Conferences as Topic. Hyperparathyroidism, Primary / therapy. Practice Guidelines as Topic

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  • (PMID = 19627760.001).
  • [ISSN] 1579-2021
  • [Journal-full-title] Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición
  • [ISO-abbreviation] Endocrinol Nutr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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69. Zald PB, Hamilton BE, Larsen ML, Cohen JI: The role of computed tomography for localization of parathyroid adenomas. Laryngoscope; 2008 Aug;118(8):1405-10
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  • [Title] The role of computed tomography for localization of parathyroid adenomas.
  • OBJECTIVE/HYPOTHESIS: The purpose of this study was to evaluate the use of computed tomography (CT) for localization of parathyroid adenomas (PA) when first-line imaging is indeterminate.
  • METHODS: A search of operating room and radiology records identified 223 surgical explorations for primary hyperparathyroidism.
  • Adenoma locations on CT, ultrasound, and nuclear scintigraphy were correlated with an independent review of operative records.
  • RESULTS: The presence of adenoma in the correct side and quadrant of the neck was predicted by CT in 89% and 77% of studies, respectively.
  • CONCLUSIONS: When first-line localization studies are indeterminate in patients with primary hyperparathyroidism, CT is a valuable, rapid, and widely available imaging modality that can be used to localize PA.
  • [MeSH-major] Adenoma / radiography. Parathyroid Neoplasms / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Hyperparathyroidism / etiology. Hyperparathyroidism / surgery. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18528308.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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70. Emmolo I, Corso HD, Borretta G, Visconti G, Piovesan A, Cesario F, Borghi F: Unexpected results using rapid intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism. World J Surg; 2005 Jun;29(6):785-8
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  • [Title] Unexpected results using rapid intraoperative parathyroid hormone monitoring during parathyroidectomy for primary hyperparathyroidism.
  • Rapid intraoperative parathyroid hormone (RIOPTH) monitoring predicts complete removal of all hypersecreting tissue by means of a significant parathyroid hormone (PTH) decrease.
  • In this study we have tried to provide an explanation for some unexpected results of RIOPTH monitoring observed during a series of 125 conventional parathyroidectomies for primary hyperthyroidism, discussing the possible consequences on the surgical strategy.
  • (1) spikes: a PTH increase 10 minutes after removal of the diseased gland was observed in three patients;.
  • (3) false-positive results: five patients with multiglandular disease showed a PTH decrease to a cure level despite excision of one adenoma only (in two of these patients a 20-minute sample showed a PTH increase soon after manipulation of the second adenoma).
  • We concluded that the spike, almost certainly a consequence of manipulating the adenoma, when detected should be considered the "true" baseline value.
  • False-positive results are usually related to a double adenoma, one functionally prevailing over the other.
  • Because in our experience manipulation of the second adenoma brought a PTH increase detected with RIOPTH monitoring, we believe that the second adenoma should be excised.
  • [MeSH-major] Hyperparathyroidism / blood. Hyperparathyroidism / surgery. Monitoring, Intraoperative / methods. Parathyroid Hormone / blood. Parathyroidectomy
  • [MeSH-minor] Aged. False Negative Reactions. False Positive Reactions. Female. Follow-Up Studies. Humans. Male. Middle Aged. Parathyroid Glands / secretion. Physical Stimulation. Retrospective Studies. Treatment Outcome

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  • (PMID = 15883666.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Angadi PV, Rekha K, Shetty SR: "An exophytic mandibular brown tumor": an unusual presentation of primary hyperparathyroidism. Oral Maxillofac Surg; 2010 Mar;14(1):67-9
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  • [Title] "An exophytic mandibular brown tumor": an unusual presentation of primary hyperparathyroidism.
  • CASE REPORT: A case of 35-year-old male patient with previously undiagnosed primary hyperparathyroidism who presented with an atypical exophytic mandibular swelling is reported.
  • PURPOSE: The aim is to alert the clinicians to include this entity although extremely rare, in the differential diagnosis of swellings in the maxillofacial region and to highlight another remarkable aspect in the multitude of presentations associated with primary hyperparathyroidism especially in the setting of normocalcemia.
  • [MeSH-major] Adenoma / diagnosis. Hyperparathyroidism, Primary / diagnosis. Magnetic Resonance Imaging. Mandibular Diseases / diagnosis. Osteitis Fibrosa Cystica / diagnosis. Parathyroid Neoplasms / diagnosis. Radiography, Panoramic
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Mandible / pathology. Parathyroid Glands / pathology. Parathyroidectomy

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  • (PMID = 19943073.001).
  • [ISSN] 1865-1569
  • [Journal-full-title] Oral and maxillofacial surgery
  • [ISO-abbreviation] Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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72. Aloumanis KP, Papapetrou PD: Corpus callosum aplasia in a young patient with a parathyroid adenoma. J Clin Neurosci; 2007 Nov;14(11):1124-6
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  • [Title] Corpus callosum aplasia in a young patient with a parathyroid adenoma.
  • A young man with primary hyperparathyroidism due to a parathyroid adenoma and aplasia of the corpus callosum is presented.
  • We hypothesize a possible genetic association of the two pathologies: a proportion of the sporadic parathyroid adenomas are associated with genetic abnormalities of chromosome 11 and in some cases of corpus callosum aplasia, aneuploidy or polyploidy of this chromosome has been described.
  • [MeSH-major] Adenoma / complications. Agenesis of Corpus Callosum. Brain Diseases / complications. Hyperparathyroidism, Primary / complications. Parathyroid Neoplasms / complications

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  • (PMID = 17954377.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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73. Casella C, Della Casa D, Baronchelli C, Di Fabio F, Mittempergher F: [Giant intrathyroidal parathyroid cyst with hyperparathyroidism: a case report]. Ann Ital Chir; 2005 Jul-Aug;76(4):391-4
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  • [Title] [Giant intrathyroidal parathyroid cyst with hyperparathyroidism: a case report].
  • Parathyroid cysts are rare lesions.
  • A correct pre-operative diagnosis is rarely formulated.
  • The Authors report a case of young woman with hyperparathyroidism do to a giant intrathyroidal parathyroid cyst.
  • Aetiology, diagnosis and management are discussed.
  • [MeSH-major] Cysts / complications. Hyperparathyroidism / etiology. Parathyroid Diseases / complications
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adenoma / pathology. Adult. Female. Follow-Up Studies. Humans. Parathyroid Glands / pathology. Parathyroid Hormone / blood. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / pathology. Time Factors. Treatment Outcome

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  • (PMID = 16550877.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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74. Muthukrishnan J, Verma A, Modi KD, Kumaresan K, Jha S: Ectopic parathyroid adenoma--the hidden culprit. J Assoc Physicians India; 2007 Jul;55:515-8
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  • [Title] Ectopic parathyroid adenoma--the hidden culprit.
  • Primary Hyperparathyroidism is known to present with protean manifestations leading to misdiagnosis in the initial stages of the disease.
  • Inability to locate the adenoma in an ectopic parathyroid gland may further delay the diagnosis of these cases.
  • Aberrant migration during development may lead to intrathyroidal or other ectopic locations of parathyroid glands.
  • Similarity in cytological picture between thyroids and parathyroids may further complicate diagnosis by fine needle aspiration cytology.
  • We encountered three such cases with the parathyroid gland adenomas in ectopic locations in which pre-operative nuclear imaging played a major role.
  • [MeSH-major] Hyperparathyroidism, Primary / diagnosis. Parathyroid Glands / pathology. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 17907504.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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75. Hosokawa Y, Yamada Y, Iwamoto R, Kurokawa R, Ihara A, Yamamoto K, Sakaguchi K, Nakatsuka S, Minami Y, Matsuzawa Y: Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. Intern Med; 2009;48(22):1957-61
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  • [Title] Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level.
  • A 64-year-old woman had normal serum calcium and plasma parathyroid hormone levels, despite an extremely high plasma parathyroid hormone-related protein (PTHrP) level.
  • Histological examination showed that the resected tumors were thyroid follicular adenomas, while immunohistochemistry revealed positive staining with a monoclonal antibody for PTHrP.
  • This is a rare case of thyroid follicular adenoma producing PTHrP in a patient with a normal serum calcium level despite elevation of plasma PTHrP.
  • [MeSH-major] Adenoma / metabolism. Calcium / blood. Parathyroid Hormone-Related Protein / biosynthesis. Parathyroid Hormone-Related Protein / secretion. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Female. Hormones, Ectopic / secretion. Humans. Middle Aged. Parathyroid Hormone / blood

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  • (PMID = 19915296.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hormones, Ectopic; 0 / Parathyroid Hormone; 0 / Parathyroid Hormone-Related Protein; SY7Q814VUP / Calcium
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76. Haddad FH, Malkawi OM, Sharbaji AA, Jbara IF, Rihani HR: Primary hyperparathyroidism. A rare cause of spinal cord compression. Saudi Med J; 2007 May;28(5):783-6
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  • [Title] Primary hyperparathyroidism. A rare cause of spinal cord compression.
  • Investigations revealed high parathyroid hormone 1152 ng/dl, calcium 10.9 mg/dl, and low phosphorus of 2.4 mg/dl after stopping calcium supplement.
  • A neck ultrasound and SESTA MIBI parathyroid scan confirmed a right lower parathyroid adenoma.
  • Two weeks later the patient underwent right parathyroidectomy that proved to be a parathyroid adenoma.
  • [MeSH-major] Hyperparathyroidism, Primary / complications. Spinal Cord Compression / etiology
  • [MeSH-minor] Adenoma / complications. Female. Humans. Middle Aged. Parathyroid Neoplasms / complications

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  • (PMID = 17457452.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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77. Elisei R, Romei C, Cosci B, Agate L, Bottici V, Molinaro E, Sculli M, Miccoli P, Basolo F, Grasso L, Pacini F, Pinchera A: RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center. J Clin Endocrinol Metab; 2007 Dec;92(12):4725-9
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  • Three different syndromes are distinguished: MEN 2A, when medullary thyroid carcinoma (MTC) is associated with pheochromocytoma and/or parathyroid adenomas; MEN 2B, when accompanied by a marfanoid habitus and/or pheochromocytoma; and familial medullary thyroid carcinoma (FMTC), when only MTC is present.


78. McCoy KL, Yim JH, Zuckerbraun BS, Ogilvie JB, Peel RL, Carty SE: Cystic parathyroid lesions: functional and nonfunctional parathyroid cysts. Arch Surg; 2009 Jan;144(1):52-6; discussion 56
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  • [Title] Cystic parathyroid lesions: functional and nonfunctional parathyroid cysts.
  • HYPOTHESIS: Functional parathyroid cysts (FPCs) and nonfunctional parathyroid cysts (NPCs) are 2 distinct clinical and histologic entities.
  • INTERVENTION: Cervical exploration for primary hyperparathyroidism or cervical mass.
  • MAIN OUTCOME MEASURES: Age, sex, morbidity, imaging results, pathologic findings, cyst characteristics (size, location, and fluid), and perioperative calcium and parathyroid hormone levels.
  • RESULTS: Cystic parathyroid lesions were found in 48 of 1769 patients (3%) studied.
  • Functional parathyroid cysts were more common than NPCs, arising in 41 of 48 patients (85%), and showed no predisposition for sex or embryologic origin.
  • Rupture of cystic parathyroid lesions during resection was associated with prolonged elevation of intraoperative parathyroid hormone levels (P =.045).
  • Cystic parathyroid lesions weighing 4 g or more were associated with the development of postoperative symptomatic hypocalcemia (P =.03).
  • Functional parathyroid cysts occurred exclusively in adenomas with cystic change, whereas NPCs (with 1 exception) were without associated adenoma on final histologic examination.
  • CONCLUSIONS: Cystic parathyroid lesions often contain turbid or colored fluid, and FPCs are more common than NPCs.
  • Neck cysts of uncertain origin should be diagnostically aspirated for parathyroid hormone content.
  • Functional parathyroid cysts and NPCs are likely 2 separate clinical and histologic entities.
  • [MeSH-major] Cysts. Parathyroid Diseases

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  • (PMID = 19153325.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Mihai R, Barczynski M, Iacobone M, Sitges-Serra A: Surgical strategy for sporadic primary hyperparathyroidism an evidence-based approach to surgical strategy, patient selection, surgical access, and reoperations. Langenbecks Arch Surg; 2009 Sep;394(5):785-98
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  • [Title] Surgical strategy for sporadic primary hyperparathyroidism an evidence-based approach to surgical strategy, patient selection, surgical access, and reoperations.
  • PURPOSE: Progress in parathyroid imaging has brought substantial changes in the surgical strategy to approach patients with sporadic primary hyperparathyroidism (pHPT).
  • The present review is focused on the safety and efficacy of limited parathyroid exploration.
  • MATERIALS AND METHODS: Review of the literature focused on studies dealing with unilateral (two-gland exploration) or selective parathyroidectomy (one-gland exploration) in selected patients with pHPT and on the classification of published reports according to the degree of evidence.
  • RESULTS: Parathyroid exploration limited to a solitary parathyroid adenoma can be considered a minimally invasive procedure that can be performed by the minicervicotomy, video-assisted, or endoscopic approaches.
  • In properly selected patients, it affords results comparable to those of four-gland bilateral exploration in terms of cure and recurrence.
  • [MeSH-major] Hyperparathyroidism, Primary / surgery
  • [MeSH-minor] Adenoma / diagnostic imaging. Adenoma / surgery. Anesthesia, Conduction. Anesthesia, Local. Humans. Minimally Invasive Surgical Procedures. Parathyroid Neoplasms / diagnostic imaging. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods. Radionuclide Imaging. Radiopharmaceuticals. Recurrence. Reoperation. Technetium Tc 99m Sestamibi

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  • (PMID = 19554347.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  • [Number-of-references] 100
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80. Minamiya Y, Saito H, Ito M, Motoyama S, Katayose Y, Ogawa J: Radio-guided thoracoscopic surgery with (99m)Tc-methoxy-isobutylisonitrile for treating an ectopic mediastinal parathyroid adenoma in an adolescent girl. Gen Thorac Cardiovasc Surg; 2009 Dec;57(12):657-9
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  • [Title] Radio-guided thoracoscopic surgery with (99m)Tc-methoxy-isobutylisonitrile for treating an ectopic mediastinal parathyroid adenoma in an adolescent girl.
  • Here we report the case of a 17-year-old girl treated for an ectopic mediastinal parathyroid adenoma using (99m)Tc-methoxy-isobutyl-isonitrile (MIBI) and radio-guided thoracoscopic surgery.
  • Her serum calcium and intact parathyroid hormone levels were elevated, and an anterior mediastinal tumor was noted on her chest computed tomography scan.
  • We suggest that radio-guided thoracoscopic surgery with (99m)Tc-MIBI is an excellent procedure for treating ectopic mediastinal parathyroid adenomas embedded in the mature thymus of adolescents and young adults.
  • [MeSH-major] Adenoma / surgery. Mediastinal Neoplasms / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Thoracoscopy. Thymus Gland / surgery

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  • (PMID = 20013101.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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81. Guthoff M, Georges G, Wehrmann M, Teichmann R, Gröne E, Risler T, Häring HU, Müssig K: [Hypercalcemic crisis due to primary hyperparathyroidism]. Dtsch Med Wochenschr; 2008 Dec;133(50):2639-43
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  • [Title] [Hypercalcemic crisis due to primary hyperparathyroidism].
  • INVESTIGATIONS: Laboratory studies showed marked hypercalcemia due to primary hyperparathyroidism and acute renal failure.
  • DIAGNOSIS, TREATMENT AND COURSE: Serum calcium levels significantly decreased after immediate rehydration, bisphosphonate administration, and continuous hemodialysis that was also indicated because of acute renal failure with anuria.
  • After knowledge of increased parathormone levels the patient underwent rapidly resection of the parathyroid adenoma which was histologically confirmed.
  • [MeSH-major] Acute Kidney Injury / complications. Adenoma / complications. Hypercalcemia / diagnosis. Hypercalcemia / etiology. Hyperparathyroidism / complications. Parathyroid Neoplasms / complications
  • [MeSH-minor] Abdominal Pain. Bone Density Conservation Agents / therapeutic use. Diagnosis, Differential. Diphosphonates / therapeutic use. Disorders of Excessive Somnolence. Female. Fluid Therapy. Humans. Middle Aged. Renal Dialysis. Tachycardia

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  • [CommentIn] Dtsch Med Wochenschr. 2009 Jan;134(5):211; author reply 212 [19180412.001]
  • (PMID = 19052999.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates
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82. Lauter K, Arnold A: Analysis of CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, as a candidate tumor suppressor gene in primary and severe secondary/tertiary hyperparathyroidism. J Bone Miner Res; 2009 Jan;24(1):102-4
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  • [Title] Analysis of CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, as a candidate tumor suppressor gene in primary and severe secondary/tertiary hyperparathyroidism.
  • CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, converts 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D, and is expressed primarily in the kidney but also in nontraditional sites including the parathyroid glands.
  • Whereas the role of locally produced 1,25-dihydroxyvitamin D is not yet clear, it is possible that it contributes importantly to vitamin D-mediated inhibition of parathyroid cell growth, so CYP27B1 can be considered a candidate parathyroid tumor suppressor gene in that its acquired inactivation in a parathyroid cell could confer a tumorigenic growth advantage.
  • Expression of CYP27B1 has also been reported to be altered in parathyroid neoplasms.
  • Because detection of inactivating mutations is the central criterion for validating a candidate tumor suppressor, we directly sequenced the coding region and all splice sites of CYP27B1 in 31 sporadic parathyroid adenomas and 31 parathyroid tumors from patients with refractory secondary/tertiary hyperparathyroidism.
  • Our findings indicate that CYP27B1 does not commonly serve as a classical tumor suppressor gene in the development of sporadic parathyroid adenomas or of refractory secondary/tertiary hyperparathyroidism.

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  • (PMID = 18767934.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / F30 DK081270; United States / NIGMS NIH HHS / GM / T32 GM008607; United States / NIDDK NIH HHS / DK / F30 DK081270-01; United States / NIGMS NIH HHS / GM / T32-GM008607
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Calcitriol; EC 1.14.- / 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • [Other-IDs] NLM/ PMC2689078
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83. Adler JT, Chen H, Schaefer S, Sippel RS: Does routine use of ultrasound result in additional thyroid procedures in patients with primary hyperparathyroidism? J Am Coll Surg; 2010 Oct;211(4):536-9
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  • [Title] Does routine use of ultrasound result in additional thyroid procedures in patients with primary hyperparathyroidism?
  • BACKGROUND: Minimally invasive parathyroidectomy for primary hyperparathyroidism depends on accurate preoperative imaging.
  • Cervical ultrasound is commonly used to localize parathyroid adenomas, but can lead to discovery of concomitant thyroid gland pathology requiring modification of the operative approach.
  • RESULTS: Between July 2002 and November 2009, 310 patients with primary hyperparathyroidism underwent ultrasound.
  • Thirteen patients (4% of all patients) underwent a thyroid operation not related to parathyroid disease: 9 thyroid lobectomies for presumably benign nodules and 4 total thyroidectomies for malignancy.
  • CONCLUSIONS: Twenty-nine percent of patients with primary hyperparathyroidism had concomitant thyroid pathology on ultrasound.
  • Routine use of ultrasound in patients with primary hyperparathyroidism leads to discovery of unrecognized thyroid pathology and cancer.
  • [MeSH-major] Adenocarcinoma, Papillary / ultrasonography. Hyperparathyroidism, Primary / surgery. Hyperparathyroidism, Primary / ultrasonography. Thyroid Neoplasms / ultrasonography. Thyroid Nodule / pathology. Thyroidectomy
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Incidental Findings. Male. Middle Aged. Reoperation. Thyroid Gland / ultrasonography. Treatment Outcome

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  • [Copyright] Copyright © 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20822743.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Power C, Kavanagh D, Hill AD, O'Higgins N, McDermott E: Unusual presentation of a giant parathyroid adenoma: report of a case. Surg Today; 2005;35(3):235-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual presentation of a giant parathyroid adenoma: report of a case.
  • Parathyroid adenomas account for most cases of primary hyperparathyroidism (1 degrees HPT).
  • Parathyroid adenomas rarely attain huge proportions.
  • We report a case of a parathyroid adenoma measuring 8 x 5 x 3.5 cm and weighing 110 g; to our knowledge the greatest mass reported in the literature.
  • Interestingly, despite its huge size it did not cause many of the hypercalcemic symptoms usually associated with larger adenomas, but rather it manifested with symptoms of local pressure, another unusual property of this atypical tumor.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Parathyroid Neoplasms / pathology. Parathyroid Neoplasms / surgery
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Female. Follow-Up Studies. Humans. Hyperparathyroidism / diagnosis. Hyperparathyroidism / etiology. Immunohistochemistry. Ireland. Neoplasm Staging. Parathyroidectomy / methods. Risk Assessment. Severity of Illness Index. Treatment Outcome

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  • (PMID = 15772795.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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85. Abouzahir A, Baite A, Azennag M, Bouchama R, Nzouba L: [Chronic calcifying pancreatitis revealing a primary hyperparathyroidism]. Rev Med Interne; 2006 Aug;27(8):640-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Chronic calcifying pancreatitis revealing a primary hyperparathyroidism].
  • INTRODUCTION: The association of pancreatitis and hyperparathyroidism is rare.
  • A major hypercalcaemia led to a primary hyperparathyroidism diagnosis.
  • The evolution was favourable after parathyroid adenoma surgery.
  • The role of parathyroid hormone remains unclear.

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  • (PMID = 16806594.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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86. Doherty DB, Mittendorf EA, Valentine AD, Perrier ND: An elderly woman with primary hyperparathyroidism exhibits improvement of neurocognitive dysfunction after parathyroidectomy. J Am Geriatr Soc; 2007 Oct;55(10):1689-91
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  • [Title] An elderly woman with primary hyperparathyroidism exhibits improvement of neurocognitive dysfunction after parathyroidectomy.
  • [MeSH-major] Adenoma / complications. Cognition Disorders / etiology. Hyperparathyroidism / etiology. Parathyroid Neoplasms / complications

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  • (PMID = 17908077.001).
  • [ISSN] 0002-8614
  • [Journal-full-title] Journal of the American Geriatrics Society
  • [ISO-abbreviation] J Am Geriatr Soc
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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87. Ge D, You Z: Expression of interleukin-17RC protein in normal human tissues. Int Arch Med; 2008;1(1):19
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  • RESULTS: IL-17RC expression in 51 normal human tissues and two benign tumors (i.e., lymphangioma and parathyroid adenoma) on the tissue microarrays was determined by immunohistochemical staining, using two polyclonal antibodies against IL-17RC.
  • IL-17RC protein was expressed in many cell types including the myocardial cells, vascular and lymphatic endothelial cells, glandular cells (of the adrenal, parathyroid, pituitary, thyroid, pancreas, parotid salivary, and subepidermal glands), epithelial cells (of the esophagus, stomach, intestine, anus, renal tubule, breast, cervix, Fallopian tube, epididymis, seminal vesicle, prostate, gallbladder, bronchus, lung, and skin), oocytes in the ovary, Sertoli cells in the testis, motor neurons in the spinal cord, autonomic ganglia and nerves in the intestine, skeletal muscle cells, adipocytes, articular chondrocytes, and synovial cells.

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  • (PMID = 18928529.001).
  • [ISSN] 1755-7682
  • [Journal-full-title] International archives of medicine
  • [ISO-abbreviation] Int Arch Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2596096
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88. Morita SY, Brownlee NA, Dackiw AP, Westra WH, Clark DP, Zeiger MA: An unusual case of recurrent hyperparathyroidism and papillary thyroid cancer. Endocr Pract; 2009 May-Jun;15(4):349-52
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  • [Title] An unusual case of recurrent hyperparathyroidism and papillary thyroid cancer.
  • OBJECTIVE: To report an unusual occurrence of recurrent hyperparathyroidism due to papillary thyroid carcinoma.
  • METHODS: We describe the clinical history, physical examination findings, laboratory values, imaging findings, and pathologic findings of a woman who developed recurrent hyperparathyroidism 13 years after successful parathyroidectomy.
  • RESULTS: A 59-year-old woman presented to our clinic with recurrent primary hyperparathyroidism.
  • In 1994, she presented with nephrolithiasis and underwent resection of a right superior parathyroid adenoma that resulted in clinical and biochemical cure.
  • In 2007, she again developed nephrolithiasis and was documented to have recurrent hyperparathyroidism.
  • Imaging studies suggested a parathyroid adenoma near the right inferior pole of the thyroid.
  • No obvious parathyroid adenoma was found and a right thyroid lobectomy was performed, which resulted in normalization of intraoperative intact parathyroid hormone levels, and the incision was closed.
  • Final pathology demonstrated no parathyroid adenoma, but instead, a 1-cm papillary thyroid carcinoma that stained positive for parathyroid hormone.
  • CONCLUSIONS: Recurrent hyperparathyroidism occurs secondary to multiple causes.
  • This case demonstrates the challenge a surgeon faces in managing recurrent disease and highlights a rare phenomenon of papillary thyroid cancer causing recurrent hyperparathyroidism.
  • [MeSH-major] Carcinoma, Papillary / complications. Carcinoma, Papillary / diagnosis. Hyperparathyroidism / complications. Hyperparathyroidism / diagnosis. Thyroid Neoplasms / complications. Thyroid Neoplasms / diagnosis

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  • (PMID = 19454395.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Phitayakorn R, McHenry CR: Hyperparathyroid crisis: use of bisphosphonates as a bridge to parathyroidectomy. J Am Coll Surg; 2008 Jun;206(6):1106-15
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  • Laboratory indices and gland weights were compared with those from patients with primary hyperparathyroidism without crisis.
  • RESULTS: Of the 292 patients operated on for hyperparathyroidism, 8 (2.8%) had hyperparathyroid crisis, consistent with rates of 1.6% to 6% reported in the literature.
  • Hyperparathyroid crisis was manifested by vomiting, nausea, or both (n=6); abdominal pain (n=3); mental status changes (n=3); pancreatitis (n=2); bone pain, osteolytic lesions, or both (n=2); electrocardiogram changes (n=1); and an acute conversion disorder (n=1).
  • Isotonic sodium chloride and furosemide, in combination with a bisphosphonate drug in 7 of 8 patients, resulted in a calcium decline from 16.2+/-1.6 mg/dL to 11.8+/-1.6 mg/dL, with resolution of electrocardiogram and mental status changes, and pancreatitis before resection of an adenoma (n=7) or carcinoma (n=1).
  • Patients with hyperparathyroid crisis had higher parathyroid hormone levels (691.7 +/-662.4 pg/mL versus 172.6 +/-147.5 pg/mL; p=0.062), larger tumor weights (7.5 +/-8.4 g versus 1.6 +/-2.1 g; p=0.085), and lower postoperative calcium levels (7.3 +/-1.6 mg/dL versus 8.7+/-0.9 mg/dL; p=0.035) than patients without crisis.
  • [MeSH-major] Diphosphonates / therapeutic use. Hypercalcemia / prevention & control. Hyperparathyroidism / drug therapy. Hyperparathyroidism / surgery

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  • (PMID = 18501807.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diphosphonates
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90. Ingui CJ, Shah NP, Oates ME: Endocrine neoplasm scintigraphy: added value of fusing SPECT/CT images compared with traditional side-by-side analysis. Clin Nucl Med; 2006 Nov;31(11):665-72
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  • These cases included: 4 I-131 (posttherapy thyroid cancer), 2 I-123 (pretherapy thyroid cancer), 2 In-111 OctreoScan (neuroendocrine neoplasm), one Tc-99m sestamibi (thyroid cancer), one Tc-99m tetrofosmin (parathyroid adenoma), and one I-123 MIBG (adrenergic neoplasm).
  • [MeSH-major] Endocrine Gland Neoplasms / diagnosis. Image Enhancement / methods. Image Interpretation, Computer-Assisted / methods. Subtraction Technique. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 17053381.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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91. Boudreaux BA, Magnuson JS, Asher SA, Desmond R, Peters GE: The role of ultrasonography in parathyroid surgery. Arch Otolaryngol Head Neck Surg; 2007 Dec;133(12):1240-4
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  • [Title] The role of ultrasonography in parathyroid surgery.
  • OBJECTIVE: To assess the role of high-resolution ultrasonography in the preoperative evaluation of patients with hyperparathyroidism.
  • PATIENTS: Three hundred seventeen patients with hyperparathyroidism who underwent preoperative assessment with ultrasonography and/or sestamibi scan and surgical treatment between October 2003 and October 2006.
  • MAIN OUTCOME MEASURES: Descriptive statistics of localization imaging studies and detection of concomitant thyroid disease in patients presenting with hyperparathyroidism.
  • RESULTS: Ultrasonography correctly localized the parathyroid adenoma(s) in 148 (69.4%) of the 229 patients with these lesions.
  • Sestamibi scans correctly localized the parathyroid adenoma(s) in 133 (58.1%) of the 229 patients.
  • Of 317 patients with hyperparathyroidism, 96 (30.3%) had clinically significant concomitant thyroid disease requiring partial or total thyroidectomy.
  • CONCLUSION: Ultrasonography is a useful tool in the preoperative evaluation of patients with hyperparathyroidism both for localization of parathyroid adenomas and for the diagnosis of concomitant thyroid disease.
  • [MeSH-major] Parathyroid Diseases / surgery. Parathyroid Diseases / ultrasonography. Parathyroidectomy / methods. Ultrasonography, Doppler, Color / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Preoperative Care / methods. Retrospective Studies. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 18086966.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Sanz C, Vezzosi D, Pigny P, Bennet A, Caron P: Multiple endocrine neoplasia type 2a and germ line C634G RET mutation diagnosed in an 80-year-old patient. Ann Endocrinol (Paris); 2009 Apr;70(2):141-4
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  • Blood tests showed that serum calcium was increased (2.93 mmol/l, normal range 2.20-2.55 mmol/l) and serum concentration of intact parathyroid hormone (iPTH) inappropriately high (198 pg/ml, normal range 15-85 pg/ml).
  • Neck ultrasonography and Tc-MIBI scintigraphy revealed a right parathyroid adenoma and a multinodular goiter.
  • After right adrenalectomy which confirmed the diagnosis of pheochromocytoma, the patient underwent total thyroidectomy with dissection of the central lymph node compartment and right parathyroidectomy.
  • On histopathologic examination, both thyroid lobes presented 13 foci of MTC without lymph node metastasis and the parathyroid gland presented a benign adenoma without hyperplasia.
  • The diagnosis of Men2a at the age of 80 years and the absence of lymph node metastasis of the multiple MTC in a carrier of C634G mutation were unusual and argued for the possible role of genetic modifier(s) in this MEN 2a patient.
  • [MeSH-minor] Adenoma / radionuclide imaging. Adrenalectomy. Aged, 80 and over. Calcitonin / blood. Catecholamines / urine. Goiter, Nodular / ultrasonography. Humans. Male. Parathyroid Neoplasms / radionuclide imaging. Parathyroidectomy. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Thyroid Gland / radionuclide imaging. Thyrotropin / blood

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  • (PMID = 19201392.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Catecholamines; 0 / Radiopharmaceuticals; 9002-71-5 / Thyrotropin; 9007-12-9 / Calcitonin; 971Z4W1S09 / Technetium Tc 99m Sestamibi; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret
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93. Kwak JY, Kim EK, Moon HJ, Kim MJ, Ahn SS, Son EJ, Sohn YM: Parathyroid incidentalomas detected on routine ultrasound-directed fine-needle aspiration biopsy in patients referred for thyroid nodules and the role of parathyroid hormone analysis in the samples. Thyroid; 2009 Jul;19(7):743-8
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  • [Title] Parathyroid incidentalomas detected on routine ultrasound-directed fine-needle aspiration biopsy in patients referred for thyroid nodules and the role of parathyroid hormone analysis in the samples.
  • BACKGROUND: The widespread use of high-resolution ultrasound (US) has allowed the detection of not only nonpalpable thyroid nodules but also parathyroid incidentalomas in the general population.
  • We sought to determine the prevalence of parathyroid incidentalomas in a large group of patients referred for US-guided fineneedle aspiration biopsy (FNAB) of suspected thyroid nodules and to investigate the role of additional parathyroid hormone (PTH) analysis in the washouts of FNAB of suspicious papathyroid nodules in these patients.
  • Among them, 112 patients (1.7%) underwent additional PTH analysis in FNAB washouts (FNA-PTH) due to suspected parathyroid lesions.
  • We evaluated the prevalence of parathyroid adenomas that were detected on thyroid US incidentally as well as the results of FNAB and FNA-PTH in parathyroid adenomas that were confirmed histopathologically.
  • RESULTS: Parathyroid incidentalomas were identified in 14 patients based on pathology and 10 patients based on elevated FNA-PTH.
  • The occurrence of parathyroid incidentalomas was 0.4% (24=6496) on thyroid US.
  • Four patients noticed symptoms related to hyperparathyroidism after FNA-PTH analysis.
  • CONCLUSIONS: The prevalence of parathyroid incidentaloma was 0.4% (24=6496) in a large series of patients referred for suspected thyroid nodules.
  • The use of FNA-PTH combined with FNAB can help clinicians accurately diagnose parathyroid incidentalomas at the time of US-guided FNAB.
  • [MeSH-major] Adenoma / ultrasonography. Biopsy, Fine-Needle. Parathyroid Hormone / analysis. Parathyroid Neoplasms / ultrasonography. Thyroid Nodule / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidental Findings. Male. Middle Aged. Parathyroid Glands / ultrasonography. Prevalence. Retrospective Studies

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  • (PMID = 19593861.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PTH protein, human; 0 / Parathyroid Hormone
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94. Niccoli-Sire P, Conte-Devolx B: [Multiple endocrine neoplasia type 2]. Ann Endocrinol (Paris); 2007 Oct;68(5):317-24
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  • [Transliterated title] Néoplasies endocriniennes multiples de type 2.
  • Three phenotypic variants have been identified: MEN2A associates medullary thyroid carcinoma (MTC) to pheochromocytoma in about 20-50% of cases and to primary hyperparathyroidism in 5-20% of cases; MEN2B associates MTC to pheochromocytoma in 50% of cases, to marphanoid habitus and to mucosal and digestive ganglioneuromatosis whereas in familial isolated medullary thyroid carcinoma (FMTC), the other components of the disease are absent.
  • In MEN2, natural history of the disease and a common embryologic origin (neural crest) may explain the phenotypes observed in the organ involved, beginning from the stage of hyperplasia to adenoma and cancer.
  • MTC represent the most frequent circumstance of diagnosis.
  • Analysis of the RET gene allows to confirm the diagnosis of MEN2 by identifying the causal germline mutation.
  • Management of MEN2 patients include thyroidectomy associated to cervical central and bilateral lymph nodes dissection for MTC, unilateral adrenalectomy for unilateral pheochromocytoma or bilateral adrenalectomy when both glands are involved, and selective resection of pathologic parathyroid glands for HPT.
  • [MeSH-minor] Adrenal Gland Neoplasms / genetics. France / epidemiology. Genetic Variation. Humans. Hyperparathyroidism / genetics. Mutation. Pheochromocytoma / genetics. Prevalence. Proto-Oncogene Proteins c-ret / genetics

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  • (PMID = 17626779.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human
  • [Number-of-references] 56
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95. Shah-Patel LR, Ghesani M, Connery C, Moore E: Gamma Probe Detection of Ectopic Parathyroid Adenoma. Radiol Case Rep; 2008;3(1):161
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  • [Title] Gamma Probe Detection of Ectopic Parathyroid Adenoma.
  • This lesion was thought to be consistent with an ectopic parathyroid adenoma.
  • However, abnormal activity was localized to the thymus gland, from which an ectopic parathyroid adenoma was successfully excised.
  • The use of the intraoperative gamma probe was critical in identifying and resecting the ectopic parathyroid adenoma in this patient, and in general, may reduce surgical time and reduce the morbidity and/or complications associated with surgical exploration.

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  • (PMID = 27303512.001).
  • [ISSN] 1930-0433
  • [Journal-full-title] Radiology case reports
  • [ISO-abbreviation] Radiol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4896118
  • [Keywords] NOTNLM ; CT, computed tomography / MRI, magnetic resonance imaging / SPECT, single photon emission computed tomography / VATS, video-assisted thoracoscopic surgery
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96. Fery-Blanco C, Prati C, Ornetti P, Bevalot J, Streit G, Toussirot E, Wendling D: [Hypercalcemia of double origin: association of multiple myeloma and ectopic parathyroidal adenoma]. Rev Med Interne; 2007 Jul;28(7):504-6
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  • [Title] [Hypercalcemia of double origin: association of multiple myeloma and ectopic parathyroidal adenoma].
  • INTRODUCTION: Multiple myeloma and primary hyperparathyroidism are two causes of hypercalcemia.
  • Biopsy diagnosed an ectopic parathyroidal adenoma.
  • DISCUSSION: Multiple myeloma and primary hyperparathyroidism can be associated.
  • Hypophosphoremia can suggest the diagnosis of hyperparathyroidism.
  • Both this observation and litterature (about twenty case reports) suggest that this double diagnosis should be systematicly evoked and explored by an assay of parathormone and a seric proteins electrophoresis in all hypercalcemia.
  • CONCLUSION: Multiple myeloma and parathyroidal adenoma should be both explored in all hypercalcemia, because they can be associated.

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  • (PMID = 17395337.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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97. Owens CL, Rekhtman N, Sokoll L, Ali SZ: Parathyroid hormone assay in fine-needle aspirate is useful in differentiating inadvertently sampled parathyroid tissue from thyroid lesions. Diagn Cytopathol; 2008 Apr;36(4):227-31
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  • [Title] Parathyroid hormone assay in fine-needle aspirate is useful in differentiating inadvertently sampled parathyroid tissue from thyroid lesions.
  • To assess the utility of chemical analysis for parathyroid hormone in the rinse (PTH-r) obtained via fine-needle aspiration (FNA) in the setting of inadvertently sampled parathyroid tissue or lesions (PTL) during "thyroid" or "neck" FNA, the authors review their experience at a large, tertiary care academic medical center.
  • In all 10 cases with PTH-r the cytologic diagnosis was PTL or included PTL in the differential.
  • [MeSH-major] Diagnostic Errors / prevention & control. Parathyroid Glands / pathology. Parathyroid Hormone / analysis. Thyroid Gland / pathology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adult. Aged. Biopsy, Fine-Needle. Calcium / blood. Female. Humans. Male. Middle Aged. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / pathology. Retrospective Studies. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18335560.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
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98. Temmim L, Sinowatz F, Hussein WI, Al-Sanea O, El-Khodary H: Intrathyroidal parathyroid carcinoma: a case report with clinical and histological findings. Diagn Pathol; 2008;3:46
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  • [Title] Intrathyroidal parathyroid carcinoma: a case report with clinical and histological findings.
  • The chance of an intrathyroidal occurrence of a parathyroid gland is about 1-3%.
  • Among the causes of hyperparathyroidism, parathyroid cases occur in less than 1% of patients.
  • Here we present the case of a 63 year old Saudi female suffering from an intrathyroidal parathyroid carcinoma.
  • The suspicion coming from the clinical investigations that the removed tumor tissue may be a parathyroid carcinoma could be confirmed by histology.
  • Although parathyroid adenoma and carcinoma have disparate natural history, it can be difficult to differentiate between the two entities.
  • Clinical presentation, operative findings may raise suspicion, but may not be conclusive especially if there is no evidence of invasion or metastasis, especially if the gland was intrathyroidal.

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  • [Cites] Diagn Pathol. 2008;3:2 [18190715.001]
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  • (PMID = 19032735.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2627811
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99. Moosgaard B, Vestergaard P, Heickendorff L, Melsen F, Christiansen P, Mosekilde L: Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study. Eur J Endocrinol; 2006 Aug;155(2):237-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study.
  • BACKGROUND: Primary hyperparathyroidism (PHPT) is associated with reduced plasma 25-hydroxyvitamin D (P-25OHD) and usually increased plasma 1alpha,25-dihydroxyvitamin D (P-1,25(OH)2D).
  • Parathyroid tissue expresses the vitamin D receptor and it is thought that circulating 1,25(OH)2D participate in the regulation of parathyroid cell proliferation, differentiation and secretion.
  • AIM: To investigate the relations between circulating levels of 1,25(OH)2D and 25OHD respectively and parathyroid adenoma weight (AW), plasma-parathyroid hormone (P-PTH) and PTH secretion expressed as P-PTH/AW.
  • MATERIAL: One hundred and seventy-one consecutive hypercalcaemic caucasian patients aged 19-87 years (median 63, 84% females) with surgically proven parathyroid adenoma.
  • Following adjustment, it was correlated positively to P-PTH, calcium (Ca) and alkaline phosphatase (AP) and inversely to plasma phosphate in a multiple regression model.
  • The P-PTH:AW ratio correlated inversely to P-25OHD (P<0.05), but showed no relations to plasma levels of Ca, phosphate or 1,25(OH)2D (P=0.22).

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  • (PMID = 16868136.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 1406-16-2 / Vitamin D; 64719-49-9 / 25-hydroxyvitamin D; 66772-14-3 / 1,25-dihydroxyvitamin D
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100. Neumann DR, Obuchowski NA, Difilippo FP: Preoperative 123I/99mTc-sestamibi subtraction SPECT and SPECT/CT in primary hyperparathyroidism. J Nucl Med; 2008 Dec;49(12):2012-7
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  • [Title] Preoperative 123I/99mTc-sestamibi subtraction SPECT and SPECT/CT in primary hyperparathyroidism.
  • The trend toward focused surgical parathyroidectomy requires precise preoperative localization of parathyroid lesions in patients with hyperparathyroidism.
  • The purpose of this study was to directly compare the diagnostic accuracy of (99m)Tc-sestamibi/(123)I subtraction SPECT with SPECT/CT for the localization of abnormal parathyroid glands in patients with primary hyperparathyroidism.
  • METHODS: A total of 61 consecutive surgical patients with primary hyperparathyroidism underwent both (123)I/(99m)Tc-sestamibi subtraction SPECT and SPECT/CT scans preoperatively, using a hybrid SPECT/CT instrument that combined a dual-detector SPECT camera with a 6-slice multidetector spiral CT scanner.
  • RESULTS: Surgery was successful in 57 patients (solitary parathyroid adenoma in 48 patients, double parathyroid adenomas in 6 patients, and 10 hyperplastic parathyroid glands in 3 patients).
  • CONCLUSION: SPECT/CT is significantly more specific than dual-isotope subtraction SPECT for the preoperative identification of parathyroid lesions in patients with primary hyperparathyroidism.
  • [MeSH-major] Hyperparathyroidism / diagnosis. Iodine Radioisotopes. Subtraction Technique. Technetium Tc 99m Sestamibi. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 18997051.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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