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1. Floyd HS, Jennings-Gee JE, Kock ND, Miller MS: Genetic and epigenetic alterations in lung tumors from bitransgenic Ki-rasG12C expressing mice. Mol Carcinog; 2006 Jul;45(7):506-17
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  • [Title] Genetic and epigenetic alterations in lung tumors from bitransgenic Ki-rasG12C expressing mice.
  • Mutations in Ki-ras occur in approximately 30-50% of patients with adenocarcinoma (AC) of the lung.
  • We previously reported the development of a bitransgenic mouse model that expressed the human Ki-ras(G12C) allele in a lung-specific, tetracycline-inducible manner and gave rise to benign lung tumors.
  • In the current study, these benign tumors, which represent relatively early lesions in neoplastic progression, were analyzed for molecular alterations secondary to mutant Ki-ras expression to determine the gene(s) that contribute to adenoma (AD) development.
  • A subset of the lung tumors (8/28) displayed reduced levels of p16(Ink4a) expression (P = 0.02).
  • Immunohistochemical analysis confirmed the upregulation of p19(Arf) and survivin in all 10 of the lung tumors examined.
  • In addition, increased levels of activated p53 were found in lung tumor tissues stained with an anti-phospho-p53 antibody, while an absence of staining was observed with an anti-phospho-pRb antibody in both normal control and tumor tissue.
  • These data thus identify alterations in specific genes and pathways that combine with the mutation in Ki-ras to promote the formation of benign lung tumors and suggest potential targets for the development of novel chemotherapeutic and chemopreventive agents during the early stages of lung tumor progression.
  • [MeSH-major] Genes, ras / genetics. Lung Neoplasms / genetics. Polymorphism, Single Nucleotide. ras Proteins / genetics


2. Zaffaroni D, Spinola M, Galvan A, Falvella FS, Pazzaglia S, Saran A, Mancuso MT, Galbiati F, Pignatiello C, Cabrera W, Ibanez O, Manenti G, Dragani TA: Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis. Oncogene; 2005 Feb 3;24(6):1084-90
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  • [Title] Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis.
  • Analysis of seven candidate genes mapping in the 1-Mb region of the mouse pulmonary adenoma resistance 4 (Par4) locus revealed a single amino-acid change, consisting in a nonconservative Arg968Cys variation in the juxtamembrane domain of the Met proto-oncogene-encoded protein.
  • Analysis of genomic DNA of 126 lung adenocarcinoma patients for the Met juxtamembrane domain revealed the same Arg/Cys variation at the mouse homologous position in one patient; two other patients carried additional variants in the same domain, suggesting a potential role for rare MET juxtamembrane variants in human lung cancer.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / physiopathology. Carcinoma, Non-Small-Cell Lung / genetics. Carcinoma, Non-Small-Cell Lung / physiopathology. Cell Transformation, Neoplastic. Genetic Predisposition to Disease. Lung Neoplasms / genetics. Lung Neoplasms / physiopathology. Proto-Oncogene Proteins / genetics. Receptors, Growth Factor / genetics


3. National Toxicology Program: Toxicology and carcinogenesis studies of divinylbenzene-HP (Cas No. 1321-74-0) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2006 Nov;(534):1-290
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  • Following combined analysis of single and step-section data, the incidences of renal tubule adenoma and adenoma or carcinoma (combined) were marginally higher in 200 and 400 ppm males, and the incidence of renal tubule hyperplasia was significantly increased in 400 ppm males.
  • The incidence of focal chronic inflammation in the lung of 400 ppm males was significantly greater than in the chamber control group.
  • The incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) in 100 ppm males were greater than chamber control incidences, but the incidences of adenoma or carcinoma (combined) were within the historical control range.
  • The incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) in all exposed groups of females were generally greater than those of the chamber controls; the incidences were at the upper end or exceeded the historical control ranges.
  • There was equivocal evidence of carcinogenic activity of divinylbenzene-HP in female B6C3F1 mice based on the incidences of alveolar/bronchiolar adenoma or carcinoma (combined) in the lung.
  • Exposure to divinylbenzene-HP caused nonneoplastic lesions of the nasal cavity in male and female rats and of the lung and nasal cavity in male and female mice.

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  • (PMID = 17342197.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vinyl Compounds; IZ715T4SBU / divinyl benzene
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4. Bień S, Sygut J, Kopczyński J, Postuła S, Ziółkowska M: [Salivary duct carcinoma--a clinicopathological analysis of five cases]. Otolaryngol Pol; 2007;61(1):33-8
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  • In 3 cases the second malignant tumor was present--synchronously (SDC + pleomorphic adenoma in parotid gland; SDC + squamous cell carcinoma in hypopharynx) or metachroneously (squamous cell carcinoma of upper lip followed by SDC).
  • The three patients are alive with distant metastases to the lung and bones (77, 38 and 18 months after primary treatment was completed).

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  • (PMID = 17605416.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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5. Devesa SS, Bray F, Vizcaino AP, Parkin DM: International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer; 2005 Nov 1;117(2):294-9
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  • [Title] International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising.
  • Lung cancer rates have peaked among men in many areas of the world, but rates among women continue to rise.
  • Most lung cancers are squamous cell carcinoma, small cell carcinoma, or adenocarcinoma; trends vary according to type.
  • Rates of all lung cancer types among women and adenocarcinoma among men continue to rise despite declining cigarette use in many Western countries and shifts to filtered/low-tar cigarettes.
  • Renewed efforts toward cessation and prevention are mandatory to curb the prevalence of cigarette smoking and to reduce lung cancer rates eventually.
  • [MeSH-major] Adenoma / epidemiology. Lung Neoplasms / classification. Lung Neoplasms / epidemiology

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  • (PMID = 15900604.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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6. Yan Y, Wang Y, Tan Q, Hara Y, Yun TK, Lubet RA, You M: Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. Neoplasia; 2006 Jan;8(1):52-8
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  • [Title] Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
  • The objective of this investigation was to determine the efficacy of several novel agents in preventing lung tumorigenesis in mice.
  • We evaluated polyphenon E, red ginseng, and rapamycin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene for their ability to inhibit pulmonary adenoma formation and growth.
  • This result provided key evidence in support of a phase II clinical chemoprevention trial of lung cancer.
  • The mammalian target of rapamycin inhibitor rapamycin showed significant efficacy against lung tumor growth in the tumor progression protocol and reduced tumor load by 84%.
  • The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice.

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  • (PMID = 16533426.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA058554; United States / NCI NIH HHS / CA / P01 CA9696401
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Anticarcinogenic Agents; 0 / Antineoplastic Agents; 0 / Tea; 0 / polyphenon E; 3417WMA06D / Benzo(a)pyrene; 8R1V1STN48 / Catechin; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC1584290
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7. Gautschi O, Ratschiller D, Gugger M, Betticher DC, Heighway J: Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer; 2007 Jan;55(1):1-14
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  • [Title] Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation.
  • PURPOSE: To review the evidence implicating the deregulation of cyclin D1 in the pathogenesis of non-small cell lung cancer (NSCLC), and to discuss the opportunities for targeted clinical intervention.
  • Genotype has been correlated with the risk and/or severity of disease or drug response across a range of malignancies, including lung cancer.
  • CONCLUSION: Current data indicate that cyclin D1 overexpression is not a consequence of, but rather a pivotal element in the process of malignant transformation in the lung and other tissues.
  • This understanding may open new avenues for lung cancer diagnosis, treatment and prevention.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / physiopathology. Cyclin D1 / genetics. Lung Neoplasms / pathology. Lung Neoplasms / physiopathology
  • [MeSH-minor] Adenoma / pathology. Adenoma / physiopathology. Cell Transformation, Neoplastic. Gene Expression Regulation, Neoplastic. Glioblastoma / pathology. Glioblastoma / physiopathology. Humans. Polymorphism, Genetic


8. Duprez R, Thimon S, Kerdraon R, Bonneau C, Metois D, Michenet P: [Tumor-to-tumor metastasis: report of three cases]. Ann Pathol; 2009 Dec;29(6):507-11
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  • [Transliterated title] Métastases d'une tumeur dans une autre tumeur : à propos de trois cas.
  • We report three cases of tumor metastasizing in another tumor: a clear cell renal cell carcinoma in a vesicular thyroid adenoma, a lung carcinoma in a meningioma and a neuroendocrine lung carcinoma in a clear cell renal cell carcinoma.
  • According to the literature, clear cell renal cell carcinoma is the most common tumor recipient of metastasis while lung carcinoma is the most common donor tumor.
  • [MeSH-major] Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Meningeal Neoplasms / pathology. Meningioma / pathology. Neoplasm Metastasis / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 20005442.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 68238-35-7 / Keratins
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9. Shen J, Liu J, Xie Y, Diwan BA, Waalkes MP: Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure. Toxicol Sci; 2007 Feb;95(2):313-20
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  • [Title] Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.
  • Arsenic is a human pulmonary carcinogen.
  • Our work indicates that in utero arsenic exposure in mice can induce or initiate lung cancer in female offspring.
  • To define early molecular changes, pregnant C3H mice were given 85 ppm arsenic in drinking water from days 8 to 18 of gestation and expression of selected genes in the fetal lung or in lung tumors developing in adults was examined.
  • Transplacental arsenic exposure increased estrogen receptor-alpha (ER-alpha) transcript and protein levels in the female fetal lung.
  • The insulin growth factor system, which can be influenced by ER and has been implicated in the pulmonary oncogenic process, was activated in fetal lung after gestational arsenic exposure.
  • In utero arsenic exposure also induced overexpression of alpha-fetoprotein, epidermal growth factor receptor, L-myc, and metallothionein-1 in fetal lung, all of which are associated with lung cancer.
  • Lung adenoma and adenocarcinoma from adult female mice exposed to arsenic in utero showed widespread, intense nuclear ER-alpha expression.
  • In contrast, normal adult lung and diethylnitrosamine-induced lung adenocarcinoma showed little evidence of ER-alpha expression.
  • Thus, transplacental arsenic exposure at a carcinogenic dose produced aberrant estrogen-linked pulmonary gene expression.
  • ER-alpha activation was specifically associated with arsenic-induced lung adenocarcinoma and adenoma but not with nitrosamine-induced lung tumors.
  • These data provide evidence that arsenic-induced aberrant ER signaling could disrupt early life stage genetic programing in the lung leading eventually to lung tumor formation much later in adulthood.

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  • (PMID = 17077188.001).
  • [ISSN] 1096-6080
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / NIH0011069698; United States / Intramural NIH HHS / / ; United States / PHS HHS / / NIH0011069698; United States / NCI NIH HHS / CA / N01CO12400; United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arsenites; 0 / Carcinogens, Environmental; 0 / Sodium Compounds; 48OVY2OC72 / sodium arsenite
  • [Other-IDs] NLM/ NIHMS33564; NLM/ PMC2692318
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10. Kosseifi SG, Nassour DN, Shaikh MA, Sarubbi FA, Jordan RM, Peiris AN: Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review. Tenn Med; 2007 Dec;100(12):44-6
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  • [Title] Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review.
  • We report a novel presentation of Histoplasmosis as pulmonary nodules in a patient with Cushing's disease.
  • [MeSH-major] Adenoma / complications. Histoplasmosis / etiology. Lung Diseases / etiology. Pituitary ACTH Hypersecretion / complications. Pituitary Neoplasms / complications

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  • (PMID = 18183856.001).
  • [ISSN] 1088-6222
  • [Journal-full-title] Tennessee medicine : journal of the Tennessee Medical Association
  • [ISO-abbreviation] Tenn Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0O54ZQ14I9 / Aminoglutethimide; 304NUG5GF4 / Itraconazole; 7S5I7G3JQL / Dexamethasone; R9400W927I / Ketoconazole
  • [Number-of-references] 16
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11. Daugherty SE, Platz EA, Shugart YY, Fallin MD, Isaacs WB, Chatterjee N, Welch R, Huang WY, Hayes RB: Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. Cancer Epidemiol Biomarkers Prev; 2007 Aug;16(8):1536-42
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  • [Title] Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.
  • METHODS: We conducted a case-control study of 725 advanced distal colorectal adenoma cases and 729 frequency-matched controls from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
  • RESULTS: The 201L allele of S201L [TT versus CC: odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.15-2.62; TC versus CC: OR, 1.17; 95% CI, 0.93-1.49] and the 277E allele of K277E (GG versus AA: OR, 1.66; 95% CI, 1.03-2.68; GA versus AA: OR, 1.21; 95% CI, 0.96-1.53) were associated with increased risk of advanced distal colorectal adenoma (both P(trend) </= 0.02); the TGTGCG haplotype of six informative single nucleotide polymorphisms was also associated with increased risk (OR, 1.27; 95% CI, 1.03-1.55).
  • Regular ibuprofen users who were homozygous for the variant allele at either M9V or D175G were at reduced risk for adenoma (both P(interaction) < 0.05).
  • CONCLUSION: Our study identified variants in AMACR associated with advanced distal colorectal adenoma and pointed to potential interactions with ibuprofen use.
  • [MeSH-major] Adenoma / enzymology. Colonic Neoplasms / enzymology. Genetic Variation / genetics. Racemases and Epimerases / genetics. Rectal Neoplasms / enzymology

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  • (PMID = 17684125.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400; United States / NCI NIH HHS / CA / T32 CA09314; United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 30KYC7MIAI / Aspartic Acid; 3KX376GY7L / Glutamic Acid; 452VLY9402 / Serine; AE28F7PNPL / Methionine; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase; GMW67QNF9C / Leucine; HG18B9YRS7 / Valine; K3Z4F929H6 / Lysine; TE7660XO1C / Glycine; WK2XYI10QM / Ibuprofen
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12. Auerbach SS, Bristol DW, Peckham JC, Travlos GS, Hébert CD, Chhabra RS: Toxicity and carcinogenicity studies of methylene blue trihydrate in F344N rats and B6C3F1 mice. Food Chem Toxicol; 2010 Jan;48(1):169-77
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  • The incidences of pancreatic islet cell adenoma and adenoma or carcinoma (combined) were increased in all dosed groups of male rats, but increases were statistically significant in 25mg/kg bw/day males only and the dose-response was non-linear.
  • There were no significant increases in neoplastic transformation observed in the mice; however, positive trends were noted for adenoma or carcinoma (combined) of the small intestine and malignant lymphoma.
  • [MeSH-minor] Animals. Blood Cell Count. Body Weight / drug effects. Carcinogenicity Tests. Dose-Response Relationship, Drug. Female. Hematopoietic Stem Cells / drug effects. Hyperplasia / chemically induced. Hyperplasia / pathology. Kaplan-Meier Estimate. Lung / pathology. Male. Mammary Neoplasms, Experimental / chemically induced. Mammary Neoplasms, Experimental / pathology. Mice. Mice, Inbred Strains. Neoplasms / chemically induced. Neoplasms / pathology. Rats. Rats, Inbred F344. Sex Characteristics. Species Specificity. Survival Analysis

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  • [Copyright] Published by Elsevier Ltd.
  • (PMID = 19804809.001).
  • [ISSN] 1873-6351
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Grant] United States / FDA HHS / BB / 1 Z01 ESO45004-11 BB; United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; T42P99266K / Methylene Blue
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13. Okamura M, Unami A, Matsumoto M, Oishi Y, Kashida Y, Mitsumori K: Gene expression analysis of urethane-induced lung tumors in ras H2 mice. Toxicology; 2006 Jan 16;217(2-3):129-38
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  • [Title] Gene expression analysis of urethane-induced lung tumors in ras H2 mice.
  • Subsequently, microarray and RT-PCR analyses for the transgene and some molecules involved in the Ras pathway were performed on the induced lung tumors.
  • In the microarray analysis, gene expression profiles of normal lungs and adenomas showed a distinct pattern, and several genes related to the cell cycle and nucleotide metabolism were up-regulated in the adenomas.
  • RT-PCR confirmed the overexpression of the transgene in lung tumors; however, the up-regulation of the mouse endogenous ras genes was not observed.
  • [MeSH-major] Gene Expression Regulation, Neoplastic / drug effects. Genes, ras / genetics. Lung Neoplasms / genetics. Urethane / toxicity
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / genetics. Adenoma / pathology. Animals. Cluster Analysis. Gene Expression Profiling / methods. Humans. Injections, Intraperitoneal. Male. Mice. Mice, Transgenic. Oligonucleotide Array Sequence Analysis. RNA, Neoplasm / genetics. RNA, Neoplasm / isolation & purification. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16289808.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 3IN71E75Z5 / Urethane
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14. Manucha V, Ioffe OB: Metastasizing pleomorphic adenoma of the salivary gland. Arch Pathol Lab Med; 2008 Sep;132(9):1445-7
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  • [Title] Metastasizing pleomorphic adenoma of the salivary gland.
  • Metastasizing pleomorphic adenoma of salivary glands is a group of rare tumors that are histologically identical to benign mixed tumors and that inexplicably metastasize.
  • A review of the literature revealed that it usually occurs after multiple local recurrences, and the interval between diagnosis of primary pleomorphic adenoma and metastases ranges between 3 and 52 years.
  • The most common site for metastasis is bone, followed by the head and neck and lung.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Invasiveness / pathology. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / secondary

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  • (PMID = 18788859.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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15. Ilhan HD, Oner FH, Sarioglu S, Lebe B, Saatci AO: Bilateral choroidal metastasis from carcinoma ex pleomorphic adenoma of the parotid gland. Clin Exp Ophthalmol; 2005 Feb;33(1):70-2
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  • [Title] Bilateral choroidal metastasis from carcinoma ex pleomorphic adenoma of the parotid gland.
  • The histological, clinical and angiographic findings are reported of a 34-year-old man with bilateral visual loss who had left parotidectomy with subsequent radiotherapy due to carcinoma ex pleomorphic adenoma of the parotid gland 1 year before.
  • At the time of ocular diagnosis, lung, pleura and pharynx metastases had recently been revealed.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma, Pleomorphic / pathology. Choroid Neoplasms / secondary. Parotid Neoplasms / pathology

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  • (PMID = 15670083.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Coloring Agents; IX6J1063HV / Indocyanine Green
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16. Kuwahara M, Nagafuchi M, Rikimaru T, Iwasaki A, Shirakusa T: Pulmonary papillary adenoma. Gen Thorac Cardiovasc Surg; 2010 Oct;58(10):542-5
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  • [Title] Pulmonary papillary adenoma.
  • We present a rare case of solitary pulmonary papillary adenoma.
  • The histological features were consistent with pulmonary papillary adenoma.
  • Only 20 cases of pulmonary papillary adenoma have been reported in the literature.
  • [MeSH-major] Adenoma / pathology. Lung Neoplasms / pathology. Solitary Pulmonary Nodule / pathology

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  • [Cites] Virchows Arch. 2000 Mar;436(3):289-95 [10782889.001]
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  • (PMID = 20941571.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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17. Hughes S, Williams RD, Webb E, Houlston RS: Meta-analysis and pooled re-analysis of copy number changes in colorectal cancer detected by comparative genomic hybridization. Anticancer Res; 2006 Sep-Oct;26(5A):3439-44
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  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. DNA, Neoplasm / genetics. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis / pathology. Neoplasm Staging. Nucleic Acid Hybridization. Peritoneal Neoplasms / genetics

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  • (PMID = 17094464.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Comparative Study; Meta-Analysis; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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18. Trepp R, Padberg BC, Varga Z, Cathomas R, Inauen R, Reinhart WH: Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation. Pathol Res Pract; 2010 May 15;206(5):334-7
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  • These include multifocal myoepitheliomatosis, the rare mixed tumor or pleomorphic adenoma, adenoid cystic carcinoma, adenomyoepithelioma and myoepithelial carcinoma (malignant myoepithelioma).
  • Despite an extensive chemotherapy and radiotherapy, the tumor was rapidly progressive, forming a finally exulcerating local tumor relapse and widespread metastases to the myocardium, lungs, liver, kidneys and skin.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / secondary. Kidney Neoplasms / secondary. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Skin Neoplasms / secondary


19. NTP technical report on the toxicology and carcinogenesis studies of 1,2-dibromo-2,4-dicyanobutane (CAS No. 35691-65-7) in F344/N rats and B6C3F1 mice (dermal studies). Natl Toxicol Program Tech Rep Ser; 2010 Jun;(555):1-171
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  • The liver and lung weights of dosed females were generally significantly less than those of the vehicle control group.
  • The combined incidence of mammary gland fibroadenoma, adenoma, or adenocarcinoma occurred with a negative trend, and the incidence was significantly decreased in 6 mg/kg female rats.

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  • (PMID = 20725155.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nitriles; YX089CPS05 / 1,2-dibromo-2,4-dicyanobutane
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20. Khoury T, Balos L, McGrath B, Wong MK, Cheney RT, Tan D: Malignant glomus tumor: a case report and review of literature, focusing on its clinicopathologic features and immunohistochemical profile. Am J Dermatopathol; 2005 Oct;27(5):428-31
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  • Multiple lung metastases were evident at 8-month follow-up.
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Diagnosis, Differential. Female. Hand / pathology. Humans. Immunohistochemistry. Lung Neoplasms / secondary. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16148414.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Witschi H: The complexities of an apparently simple lung tumor model: The A/J mouse. Exp Toxicol Pathol; 2005 Jul;57 Suppl 1:171-81
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  • [Title] The complexities of an apparently simple lung tumor model: The A/J mouse.
  • Lung surface tumors are counted and lung tumor multiplicity (average number of tumors per lung, including non-tumor bearing animals) is calculated.
  • Results obtained in four different laboratories during the past 8 years have consistently shown significant increases in lung tumor multiplicities in tobacco smoke exposed animals.
  • The counting of surface tumors only may occasionally underestimate total number of lung tumors and thus yield false negatives.
  • Studies with filtered tobacco smoke have suggested that benzo(a)pyrene or tobacco smoke-specific nitrosamines cannot account for lung carcinogenesis in mice; the most likely single agent to cause lung tumors is 1,3-butadiene.
  • While it is easy to detect a 70-100% decrease in lung tumor multiplicity caused by a chemopreventive agent using group sizes of 20-30 animals, the detection of smaller reductions (20-50%) would require group sizes in the hundreds.
  • [MeSH-major] Adenocarcinoma / chemically induced. Adenoma / chemically induced. Disease Models, Animal. Lung Neoplasms / chemically induced. Tobacco Smoke Pollution / adverse effects

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  • (PMID = 16092725.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA96217; United States / NIEHS NIH HHS / ES / ES05707; United States / NIEHS NIH HHS / ES / ES07499
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Tobacco Smoke Pollution
  • [Number-of-references] 62
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22. Onishi M, Saito M, Sokuza Y, Mori C, Nishikawa T, Shimizu K, Sugata E, Tsujiuchi T: Numerical changes in the mitochondrial DNA displacement loop in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Mutat Res; 2008 Feb 1;638(1-2):133-8
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  • [Title] Numerical changes in the mitochondrial DNA displacement loop in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
  • Mutations in the mitochondrial DNA (mtDNA) displacement loop (D-loop) region were investigated to clarify the possible molecular mechanisms underlying the development of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats.
  • Eleven out of 24 hyperplasias (45.6%), 8 out of 16 adenomas (50.0%), and 14 out of 21 adenocarcinomas (66.7%) showed numerical changes, in a polymeric C-tract at positions 16,086-16,092 of the mtDNA D-loop, with a one base insertion of cytosine increasing the length of the C-tract, from the seven nucleotides observed in normal lung tissues from non-BHP treated rats, to eight.
  • These changes were all homoplasmic and no changes were found in lung lesions when the length of the C-tract in the normal lung tissues adjacent to the lesions was seven.
  • These results suggest that alterations in the mtDNA D-loop may occur in an early phase of lung carcinogenesis induced in rats by BHP.
  • [MeSH-major] DNA, Mitochondrial / drug effects. Lung Neoplasms / chemically induced. Lung Neoplasms / genetics. Mutation. Nitrosamines / pharmacology
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / genetics. Adenoma / chemically induced. Adenoma / genetics. Animals. Hyperplasia / chemically induced. Hyperplasia / genetics. Lung / pathology. Male. Mutagens / pharmacology. Rats. Rats, Wistar

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  • (PMID = 17964613.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / Mutagens; 0 / Nitrosamines; 53609-64-6 / diisopropanolnitrosamine
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23. Di Pace RF, Massa S, Ribeiro OG, Cabrera WH, De Franco M, Starobinas N, Seman M, Ibañez OC: Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness. Carcinogenesis; 2006 Aug;27(8):1517-25
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  • [Title] Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.
  • Mouse lines produced by bidirectional selection on the basis of maximum (AIRmax) or minimum (AIRmin) acute inflammatory reactions were examined for the development of chemically induced acute colitis and colon tumors and the development of lung tumors.
  • At the latter time point, however, multiple lung adenomas and large adenocarcinomas were found in AIRmin but not in AIRmax mice.
  • The results demonstrate that genetic determinants of the inflammatory response differentially influence susceptibility to colon and lung carcinogenesis in the AIRmax and AIRmin mouse model.
  • [MeSH-major] Cell Transformation, Neoplastic. Colitis / genetics. Colonic Neoplasms / genetics. Genetic Predisposition to Disease / genetics. Immunity, Cellular / genetics. Inflammation / genetics. Lung Neoplasms / genetics
  • [MeSH-minor] 1,2-Dimethylhydrazine / toxicity. Acute Disease. Adenocarcinoma / chemically induced. Adenocarcinoma / genetics. Adenocarcinoma / immunology. Adenoma / chemically induced. Adenoma / genetics. Adenoma / immunology. Animals. Antiviral Agents / toxicity. Carcinogens / toxicity. Cells, Cultured. Crosses, Genetic. Cytokines / metabolism. Dextran Sulfate / toxicity. Disease Models, Animal. Mice. Mice, Inbred Strains

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  • (PMID = 16774945.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Carcinogens; 0 / Cytokines; 9042-14-2 / Dextran Sulfate; IX068S9745 / 1,2-Dimethylhydrazine
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24. Dong YC, Wu B, Wang JD, Rao Q, Ma HH, Zhang RS, Zhou HB, Lu ZF, Zhou XJ: [Expression and clinical significance of kidney injury molecule-1 in renal epithelial neoplasms]. Zhonghua Bing Li Xue Za Zhi; 2010 Jan;39(1):35-9
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  • [MeSH-minor] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism. Bone Neoplasms / metabolism. Bone Neoplasms / secondary. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Chromosomes, Human, X. Gene Fusion. Humans. Lung Neoplasms / metabolism. Lung Neoplasms / secondary. Retrospective Studies. Translocation, Genetic

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  • (PMID = 20388397.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / CDH16 protein, human; 0 / Cadherins; 0 / HAVCR1 protein, human; 0 / Membrane Glycoproteins; 0 / Receptors, Virus; 0 / TFE3 protein, human
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25. D'Agostini F, Mastracci L, Izzotti A, Balansky R, Pennisi TM, Steele VE, De Flora S: Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice. Cancer Prev Res (Phila); 2009 Jun;2(6):546-56
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  • Our discovery that the perinatal period involves nucleotide modifications and gene overexpression in mouse lung prompted us to evaluate whether mice may become more susceptible to cigarette smoke when exposure starts immediately after birth.
  • However, after 4 months of exposure to ECS followed by 7 months of recovery in filtered air, the lung tumor yield was rather low.
  • After weanling, the mice exposed to ECS since birth underwent a variety of alterations of molecular and cytogenetical end points, and 11 months after birth, they exhibited significant histopathologic changes, such as pulmonary anthracosis, emphysema, hemorrhagic areas, alveolar bronchiolarization, bronchial hyperplasia, and tumors, both benign and malignant.
  • Both phenethyl isothiocyanate and budesonide, administered daily with the diet after weanling, attenuated several alterations of ECS-related biomarkers and moderately protected the lungs from histopathologic alterations, including tumors.
  • [MeSH-major] Anticarcinogenic Agents / therapeutic use. Budesonide / therapeutic use. Isothiocyanates / therapeutic use. Lung Neoplasms / prevention & control. Tobacco Smoke Pollution / adverse effects
  • [MeSH-minor] Adenoma / etiology. Adenoma / prevention & control. Age Factors. Animals. Animals, Newborn. Apoptosis / drug effects. Bone Marrow Cells / drug effects. Bone Marrow Cells / pathology. Carcinoma / etiology. Carcinoma / prevention & control. DNA Adducts / analysis. Drug Screening Assays, Antitumor. Epithelial Cells / drug effects. Epithelial Cells / pathology. Female. Lung / chemistry. Lung / drug effects. Lung Diseases / drug therapy. Lung Diseases / pathology. Male. Mice. Precancerous Conditions / drug therapy. Precancerous Conditions / pathology. Pregnancy. Time Factors

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  • (PMID = 19491290.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN53301
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / DNA Adducts; 0 / Isothiocyanates; 0 / Tobacco Smoke Pollution; 51333-22-3 / Budesonide; 6U7TFK75KV / phenethyl isothiocyanate
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26. Malenchenko AF, Konoplia EF, Sushko SN, Savin AO, Kadukova EM, Goncharov SV: [The influence of ecological factors of Polesky State Radioecological Reserve on spontaneous and chemically induced mutagenesis and tumor formation]. Radiats Biol Radioecol; 2009 May-Jun;49(3):317-23
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  • The cycle of researches of the influence of an exposion of mice of line Af in the conditions of the zone of Chernobyl disaster on spontaneous and chemically induced mutability, lung tumour (adenomas), morphological and functional condition of alveolar macrophages, and also genetic effects in natural populations wild rodents is executed.
  • The increase in polychromatic frequency in mouse bone marrow, adenomas in lungs, and change of sensitivity of an organism to action mutagen and transgenerational transfer of genetic damages is shown.

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  • (PMID = 19637740.001).
  • [ISSN] 0869-8031
  • [Journal-full-title] Radiatsionnaia biologiia, radioecologiia
  • [ISO-abbreviation] Radiats Biol Radioecol
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Mutagens
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27. National Toxicology Program: Toxicology and carcinogenesis studies of methylene blue trihydrate (Cas No. 7220-79-3) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2008 May;(540):1-224
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  • Thymus and lung weights of 50, 100, and 200 mg/kg males (except relative lung weight at 100 mg/kg) were significantly less than those of the vehicle controls.
  • The incidences of pancreatic islet cell adenoma and adenoma or carcinoma (combined) were increased in all dosed groups of males, were significantly increased in 25 mg/kg males, and exceeded the historical range in controls (all routes).
  • The incidences of carcinoma and of adenoma or carcinoma (combined) of the small intestine occurred with a positive trend in males.

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  • (PMID = 18685714.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Mutagens; T42P99266K / Methylene Blue
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28. Igarashi M, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D: Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice. J Toxicol Sci; 2009 Apr;34(2):163-74
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  • [Title] Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
  • The present study was conducted to assess involvement of oxidative stress in lung adeno-carcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene encoding an enzyme that repairs an oxidative DNA injury 8-oxoguanine (8-oxoG).
  • Development of lung adenomas and preneoplastic atypical hypreplasias was significantly enhanced by the homo- and heterozygous Ogg1 gene deficiency only in female mice with intralesion accumulation of 8-oxoG.
  • The Egfr and K-ras gene mutations were detected at sites also found in human lung cancers with low incidences, while the Egfr gene mutation was detected for the first time in chemical lung carcinogenesis of animals.
  • It is indicated that the Ogg1 gene deficiency enhances lung adeno-carcinogenesis in mice by virtue of accelerated oxidative stress.
  • The presently utilized Ogg1 gene-deficient mice model may be useful to draw mechanism-based strategies to control human lung adenocarcinomas, especially in women.
  • [MeSH-major] Adenoma / genetics. Carcinogens / toxicity. DNA Glycosylases / genetics. Lung Neoplasms / genetics. Nitrosamines / toxicity
  • [MeSH-minor] Adenocarcinoma / pathology. Administration, Oral. Animals. Antioxidants / pharmacology. Drug Antagonism. Female. Genes, erbB-1 / genetics. Genes, ras / genetics. Humans. Infusions, Subcutaneous. Lung / drug effects. Lung / pathology. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Mutation. Precancerous Conditions / chemically induced. Precancerous Conditions / genetics. Precancerous Conditions / pathology. Sex Factors


29. Huang WY, Berndt SI, Kang D, Chatterjee N, Chanock SJ, Yeager M, Welch R, Bresalier RS, Weissfeld JL, Hayes RB: Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. Cancer Epidemiol Biomarkers Prev; 2006 Feb;15(2):306-11
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  • [Title] Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk.
  • OBJECTIVES: Nucleotide excision repair enzymes remove bulky damage caused by environmental agents, including carcinogenic polycyclic aromatic hydrocarbons found in cigarette smoke, a risk factor for colorectal adenoma.
  • Among participants randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we studied the risk of advanced colorectal adenoma in relation to cigarette smoking and selected single nucleotide polymorphisms (SNP) in the nucleotide excision repair pathway.
  • METHODS: Cases (n = 772) were subjects with left-sided advanced adenoma (>1 cm in size, high-grade dysplasia, or villous characteristics).
  • RESULTS: None of the studied SNPs were independently associated with advanced adenoma risk.
  • Smoking was related to adenoma risk and XPC polymorphisms (R492H, A499V, K939Q) modified these effects (P(interaction) from 0.03-0.003).
  • CONCLUSIONS: Examining a spectrum of polymorphic variants in nucleotide excision repair genes, we found evidence that smoking-associated risks for advanced colorectal adenoma are modified by polymorphisms in XPC, particularly haplotypes containing XPC 499V.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. DNA Repair / genetics. DNA-Binding Proteins / genetics. Polymorphism, Single Nucleotide. Smoking / genetics

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  • (PMID = 16492920.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 156533-34-5 / XPC protein, human; EC 3.6.4.- / DNA Helicases
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30. Carney JA: Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metab; 2009 Oct;94(10):3656-62
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  • One also had an adrenal cortical adenoma and the other pulmonary chondroma.
  • Five additional patients with gastric stromal tumor, paraganglioma, and pulmonary chondroma were found, and all were young women.
  • The gastric lesion was usually the presenting tumor (75%), followed by the lung lesion (15%) and the paraganglionic tumor (10%).
  • Twenty percent of the patients had adrenocortical adenoma(s), and 10% had esophageal leiomyoma(s).
  • The pulmonary tumors were asymptomatic and benign.
  • FOLLOW-UP: At follow-up, 80% of the patients were alive, two thirds with pulmonary chondroma, 25% with metastatic or residual gastric stromal tumor, and 5% with primary or metastatic paraganglioma.
  • CONCLUSION: The Carney triad is a chronic, persistent, indolent but sometimes fatal disorder of unknown etiology.
  • [MeSH-major] Adenoma. Adrenal Cortex Neoplasms. Chondroma. Esophageal Neoplasms. Leiomyoma. Lung Neoplasms. Multiple Endocrine Neoplasia. Neoplastic Syndromes, Hereditary / pathology. Paraganglioma

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  • (PMID = 19723753.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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31. National Toxicology Program: NTP Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in male F344/N rats and female B6C3F1 mice (Drinking Water Studies). Natl Toxicol Program Tech Rep Ser; 2006 Feb;(532):1-248
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  • Absolute lung weights of mice in the 350 and 750 mg/L groups were significantly less than that of the controls.
  • The incidences of hepatocellular adenoma or carcinoma (combined) occurred with a negative trend, and the incidence in the 700 mg/L group was significantly decreased relative to the control group.

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  • (PMID = 16741555.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Mutagens; 0 / Trihalomethanes; 7LN464CH2O / bromodichloromethane
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32. Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ: Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am J Respir Cell Mol Biol; 2009 Apr;40(4):443-53
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  • [Title] Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model.
  • Lung cancer is the leading cause of cancer deaths in the United States.
  • In addition to genetic abnormalities induced by cigarette smoke, several epidemiologic studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lungs, have an increased risk of lung cancer (1.3- to 4.9-fold) compared to smokers without COPD.
  • This suggests a link between chronic airway inflammation and lung carcinogenesis, independent of tobacco smoke exposure.
  • We studied this association by assaying the inflammatory impact of products of nontypeable Haemophilus influenzae, which colonizes the airways of patients with COPD, on lung cancer promotion in mice with an activated K-ras mutation in their airway epithelium.
  • Two new mouse models of lung cancer were generated by crossing mice harboring the LSL-K-ras(G12D) allele with mice containing Cre recombinase inserted into the Clara cell secretory protein (CCSP) locus, with or without the neomycin cassette excised (CCSP(Cre) and CCSP(Cre-Neo), respectively).
  • Lung lesions in CCSP(Cre-Neo)/LSL-K-ras(G12D) and CCSP(Cre)/LSL-K-ras(G12D) mice appeared at 4 and 1 month of age, respectively, and were classified as epithelial hyperplasia of the bronchioles, adenoma, and adenocarcinoma.
  • Weekly exposure of CCSP(Cre)/LSL-K-ras(G12D) mice to aerosolized nontypeable Haemophilus influenzae lysate from age 6-14 weeks resulted in neutrophil/macrophage/CD8 T-cell-associated COPD-like airway inflammation, a 3.2-fold increase in lung surface tumor number (156 +/- 9 versus 45 +/- 7), and an increase in total lung tumor burden.
  • We conclude that COPD-like airway inflammation promotes lung carcinogenesis in a background of a G12D-activated K-ras allele in airway secretory cells.

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  • (PMID = 18927348.001).
  • [ISSN] 1535-4989
  • [Journal-full-title] American journal of respiratory cell and molecular biology
  • [ISO-abbreviation] Am. J. Respir. Cell Mol. Biol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA070907; United States / NCI NIH HHS / CA / U01 CA105352
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aerosols; 0 / Bacterial Proteins; 0 / Chemokines; 0 / NF-kappa B; 0 / Porins; 0 / Scgb1a1 protein, mouse; 0 / ompP2 protein, Haemophilus influenzae; 9060-09-7 / Uteroglobin; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases; EC 3.6.5.2 / Kras2 protein, mouse; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Other-IDs] NLM/ PMC2660561
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33. Lees NP, Harrison KL, Hall CN, Margison GP, Povey AC: Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents. Gut; 2007 Mar;56(3):380-4
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  • [Title] Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents.
  • Such mutations are frequently seen in the KRAS oncogene of large colorectal adenomas, but whether adenoma or mutational risk in humans is influenced by MGMT activity and alkylating agent exposure is unclear.
  • Elevated MGMT levels were associated with an increased risk of adenoma (OR 1.17, 95% CI 1.03 to 1.33 per unit increase in activity).
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Guanine / analogs & derivatives. O(6)-Methylguanine-DNA Methyltransferase / metabolism

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  • (PMID = 16891355.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / DNA, Neoplasm; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / SSPN protein, human; 578-76-7 / 7-methylguanine; 5Z93L87A1R / Guanine; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
  • [Other-IDs] NLM/ PMC1856833
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34. Madea B, Saukko P, Oliva A, Musshoff F: Molecular pathology in forensic medicine--Introduction. Forensic Sci Int; 2010 Dec 15;203(1-3):3-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenoma / genetics. Adenoma / pathology. Algorithms. Biopsy. Blood Stains. Body Fluids. Brain / metabolism. Colonic Neoplasms / genetics. Colonic Neoplasms / pathology. Communicable Diseases / diagnosis. Communicable Diseases / genetics. Corpse Dismemberment. DNA Fingerprinting. DNA, Bacterial / genetics. DNA, Viral / genetics. Death, Sudden, Cardiac. Female. Genetic Predisposition to Disease. Humans. Loss of Heterozygosity. Lung Neoplasms / genetics. Lung Neoplasms / pathology. MicroRNAs / metabolism. Mutation. Pharmacogenetics. Physician's Role. Poisoning / metabolism. Polymerase Chain Reaction. Postmortem Changes. RNA / genetics. RNA Stability. RNA, Messenger / metabolism. Receptors, Opioid, mu / genetics. Receptors, Opioid, mu / metabolism. Tandem Repeat Sequences. Wounds and Injuries / pathology

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20728291.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / DNA, Viral; 0 / MicroRNAs; 0 / RNA, Messenger; 0 / Receptors, Opioid, mu; 63231-63-0 / RNA
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35. Sun W, Iijima T, Kano J, Kobayashi H, Li D, Morishita Y, Okubo C, Anami Y, Noguchi M: Frequent aberrant methylation of the promoter region of sterile alpha motif domain 14 in pulmonary adenocarcinoma. Cancer Sci; 2008 Nov;99(11):2177-84
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  • [Title] Frequent aberrant methylation of the promoter region of sterile alpha motif domain 14 in pulmonary adenocarcinoma.
  • In order to identify novel hypermethylated genes in early stage lung adenocarcinoma, we carried out methylated CpG island amplification, modified suppression subtractive hybridization, and methylation-specific polymerase chain reaction to identify aberrant methylation of CpG islands in the A/J mouse lung adenoma model, which histologically mimics the early stage of human pulmonary adenocarcinoma.
  • Two of them showed downregulation of their expression in human lung adenocarcinoma.
  • Most of the lung adenocarcinoma cell lines showed suppressed expression of SAMD14 together with hypermethylation at the promoter region, although an immortalized bronchial epithelium cell line (PL16B) did not show hypermethylation and did express SAMD14.
  • Hypermethylation at the CpG site of the SAMD14 promoter region was detected frequently in early invasive adenocarcinoma (8/24, 33.3%) but not in in situ adenocarcinoma (0/7, 0%) or normal lung tissue (0/31, 0%).
  • Hypermethylation of the SAMD14 gene is a specific event in pulmonary adenocarcinogenesis and malignant progression.
  • [MeSH-major] Adenocarcinoma / genetics. DNA Methylation. Lung Neoplasms / genetics. Promoter Regions, Genetic / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 18823374.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / KIF21A protein, human; 0 / Kif21a protein, mouse; 0 / Tumor Suppressor Proteins; EC 3.6.1.- / Kinesin
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36. National Toxicology Program: Toxicology and carcinogenesis studies of transplacental AZT (Cas No. 30516-87-1) in Swiss (CD-1®) mice (in utero studies). Natl Toxicol Program Tech Rep Ser; 2006 Jun;(522):1-184
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  • The incidences of alveolar/bronchiolar carcinoma and of adenoma or carcinoma (combined) in 200 and 300 mg/kg males were significantly greater than those in the vehicle controls.
  • The incidences of histiocytic cellular infiltration of the lung in 200 and 300 mg/kg males were significantly increased.

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  • (PMID = 17160102.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 4B9XT59T7S / Zidovudine
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37. King TJ, Gurley KE, Prunty J, Shin JL, Kemp CJ, Lampe PD: Deficiency in the gap junction protein connexin32 alters p27Kip1 tumor suppression and MAPK activation in a tissue-specific manner. Oncogene; 2005 Mar 03;24(10):1718-26
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  • Connexin32 knockout mice (Cx32-KO) exhibit increased chemical- and radiation-induced liver and lung tumor formation with many lung tumors demonstrating decreased levels of the tumor suppressor p27KIP1.
  • Immunohistochemical analysis revealed an increased percentage of Cx32-KO liver and lung tumors harboring active mitogen-activated protein kinase (Erk1, Erk2) pathways in contrast to lower percentages of activated wild-type (P<0.005) and DKO tumors (P=0.027).
  • This study demonstrates that tissues dependent on Cx32 tumor suppression, such as the liver and lung, exhibit altered tumorigenesis and tumor biology (MAPK pathway activation) related to p27 status.
  • [MeSH-minor] Adenoma / etiology. Animals. Cyclin-Dependent Kinase Inhibitor p27. Cytoskeletal Proteins / genetics. Enzyme Activation. Female. Genes, ras. Liver Neoplasms, Experimental / etiology. Lung Neoplasms / etiology. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Neoplasms, Radiation-Induced / etiology. Organ Specificity. Pituitary Neoplasms / etiology. Trans-Activators / genetics. Weight Gain. beta Catenin

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  • (PMID = 15608667.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM055632; United States / NIAMS NIH HHS / AR / AR47963; United States / NIGMS NIH HHS / GM / GM55632; United States / NIAID NIH HHS / AI / T32-AI07509
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, mouse; 0 / Cdkn1b protein, mouse; 0 / Cell Cycle Proteins; 0 / Connexins; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / Tumor Suppressor Proteins; 0 / beta Catenin; 0 / connexin 32; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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38. Schoen RE, Weissfeld JL, Kuller LH, Thaete FL, Evans RW, Hayes RB, Rosen CJ: Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology; 2005 Aug;129(2):464-75
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  • METHODS: Participants were asymptomatic subjects who underwent screening flexible sigmoidoscopy (FSG) within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
  • RESULTS: Four hundred fifty-eight subjects were enrolled, of which 202 subjects had an adenoma, 70 of which were an advanced adenoma.
  • In an unadjusted logistic regression analysis using sex-specific quartile cut points, subjects in quartile 4 in comparison with quartile 1 of IGF-I (odds ratio [OR] = 1.7; [95% CI: 1.0-2.9], Ptrend = .03), IGF-I/IGFBP-3 ratio (OR = 1.9 [95% CI: 1.1-3.3], Ptrend = .01), and insulin (OR = 2.1 [95% CI: 1.2-3.6], Ptrend = .04) were at increased risk of adenoma.
  • Visceral adipose tissue was not associated with adenoma risk.

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  • (PMID = 16083703.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K07-CA72561
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin; 0 / Insulin-Like Growth Factor Binding Protein 1; 0 / Insulin-Like Growth Factor Binding Protein 3
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39. Laiyemo AO, Doubeni C, Pinsky PF, Doria-Rose VP, Bresalier R, Lamerato LE, Crawford ED, Kvale P, Fouad M, Hickey T, Riley T, Weissfeld J, Schoen RE, Marcus PM, Prorok PC, Berg CD: Race and colorectal cancer disparities: health-care utilization vs different cancer susceptibilities. J Natl Cancer Inst; 2010 Apr 21;102(8):538-46
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  • METHODS: A total of 60, 572 non-Hispanic white and black participants in the ongoing Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial underwent trial-sponsored screening flexible sigmoidoscopy (FSG) without biopsy at baseline in 10 geographically dispersed centers from November 1993 to July 2001.
  • Overall, among subjects with diagnostic colonoscopy (n = 10 424), there was no statistically significant difference by race in the prevalence of adenoma, advanced adenoma, advanced pathology in small adenomas (high-grade dysplasia or villous histology in adenomas <10 mm), or colorectal cancer.
  • [MeSH-minor] Aged. Colonoscopy. Early Detection of Cancer. Female. Genetic Predisposition to Disease. Humans. Incidence. Lung Neoplasms / prevention & control. Male. Mass Screening / methods. Mass Screening / statistics & numerical data. Middle Aged. Ovarian Neoplasms / prevention & control. Prostatic Neoplasms / prevention & control. Randomized Controlled Trials as Topic. Risk Factors. Sigmoidoscopy. Socioeconomic Factors. United States / epidemiology

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  • (PMID = 20357245.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-25524; United States / NCI NIH HHS / CN / N01-CN-25513; United States / NCI NIH HHS / CN / N01-CN-25511; United States / NCI NIH HHS / CN / N01-CN-75022; United States / NCI NIH HHS / CN / N01-CN-25514; United States / NCI NIH HHS / CN / N01-CN-25512; United States / NCI NIH HHS / CN / N01-CN-25515; United States / NCI NIH HHS / CA / K01 CA127118; United States / NCI NIH HHS / CA / R01 CA151736; United States / NCI NIH HHS / CN / N01-CN-25404; United States / NCI NIH HHS / CN / N01-CN-25516; United States / NCI NIH HHS / CN / N01-CN-25476; United States / NCI NIH HHS / CN / N01-CN-25518; United States / NCI NIH HHS / CA / U01 CA151736; United States / NCI NIH HHS / CN / N01-CN-25522
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2857802
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40. Minato H, Kaji S, Kinoshita E, Kurose N, Nojima T, Kohno M, Konuma K, Ikawa H: Solitary intrapulmonary cystic lymphangioma in an infant: a case report with literature review. Pathol Res Pract; 2010 Dec 15;206(12):851-6
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  • Lymphangioma rarely presents as a solitary pulmonary lesion.
  • Chest X-ray showed a large cyst in the right lung.
  • Differential diagnoses included lobar or interstitial emphysema, bronchogenic cyst, congenital pulmonary airway malformation and alveolar adenoma.
  • A review of the literature found only 15 cases of solitary pulmonary lymphangioma.
  • In younger patients, the lesions tend to occupy more of the lung.
  • [MeSH-major] Bronchogenic Cyst / diagnosis. Lung Neoplasms / diagnosis. Lymphangioma, Cystic / diagnosis. Pulmonary Emphysema / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20952134.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / monoclonal antibody D2-40; 0 / prospero-related homeobox 1 protein
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41. Long KB, Srivastava A, Hirsch MS, Hornick JL: PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors. Am J Surg Pathol; 2010 May;34(5):723-9
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  • [Title] PAX8 Expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors.
  • In total, 190 tumors were evaluated: 156 primary WDNETs (63 PETs, 31 ileal, 5 duodenal, 5 gastric, 19 appendiceal, 13 rectal, and 20 pulmonary carcinoid tumors) and 34 liver metastases (18 PETs and 16 ileal carcinoid tumors).
  • PAX8 expression was detected in 0/20 (0%) pulmonary, 1/5 (20%) gastric, 5/5 (100%) duodenal, 0/31 (0%) ileal, 4/19 (21%) appendiceal, and 11/13 (85%) rectal carcinoid tumors.
  • PAX8 expression is absent in ileal and pulmonary carcinoid tumors.
  • [MeSH-major] Adenoma, Islet Cell / pathology. Carcinoid Tumor / pathology. Carcinoma, Islet Cell / secondary. Gastrointestinal Neoplasms / pathology. Lung Neoplasms / pathology. Paired Box Transcription Factors / metabolism. Pancreatic Neoplasms / pathology

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  • [CommentIn] Am J Surg Pathol. 2011 Dec;35(12):1906-8 [22067332.001]
  • (PMID = 20414099.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors
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42. Yamauchi N, Watanabe A, Hishinuma M, Ohashi K, Midorikawa Y, Morishita Y, Niki T, Shibahara J, Mori M, Makuuchi M, Hippo Y, Kodama T, Iwanari H, Aburatani H, Fukayama M: The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Mod Pathol; 2005 Dec;18(12):1591-8
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  • GPC3 immunoreactivity was detected in only one of 23 metastatic lesions of colorectal carcinoma, and its expression was entirely absent in the liver cell adenoma (0/7), carcinoid tumor (0/1), and cholangiocellular carcinoma (0/16).
  • [MeSH-minor] Antibodies, Monoclonal / biosynthesis. Antibodies, Monoclonal / immunology. Cell Line, Tumor. Glypicans. Hepatoblastoma / metabolism. Hepatoblastoma / pathology. Hepatocytes / metabolism. Hepatocytes / pathology. Humans. Liver / embryology. Liver / metabolism. Lung Neoplasms / metabolism. Lung Neoplasms / pathology

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  • (PMID = 15920546.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Glypicans; 0 / Heparan Sulfate Proteoglycans
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43. Bermejo JL, Eng C, Hemminki K: Cancer characteristics in Swedish families fulfilling criteria for hereditary nonpolyposis colorectal cancer. Gastroenterology; 2005 Dec;129(6):1889-99
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  • Families that fulfilled the Bethesda criteria showed increased risks of cancer in the colorectum, endometrium, small bowel, ovary, stomach, bile ducts, renal pelvis, and ureter; members of Bethesda criteria families were at decreased risks of lung and cervical cancers.
  • CONCLUSIONS: Most malignancies in the classified families reflect typical features of HNPCC (association with subsequent malignancies, accelerated adenoma-carcinoma sequence, and better survival).

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  • (PMID = 16344057.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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44. Halldorsson A, Dissanaike S, Kaye KS: Alveolar adenoma of the lung: a clinicopathological description of a case of this very unusual tumour. J Clin Pathol; 2005 Nov;58(11):1211-4
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  • [Title] Alveolar adenoma of the lung: a clinicopathological description of a case of this very unusual tumour.
  • Alveolar adenomas are extremely rare, and are probably benign lung tumours of unknown histogenesis.
  • This report describes a case of alveolar adenoma in a 43 year old white man, who presented with pleuritic chest pain.
  • A chest x ray and computerised tomography scan demonstrated a solitary left lower lobe lung nodule.
  • Histologically, the lesion was well demarcated, dominated by large and small cysts with no normal lung parenchyma.
  • [MeSH-major] Adenoma / pathology. Lung Neoplasms / pathology

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  • (PMID = 16254114.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770767
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45. Müller-Brüsselbach S, Ebrahimsade S, Jäkel J, Eckhardt J, Rapp UR, Peters JM, Moll R, Müller R: Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene. Int J Oncol; 2007 Sep;31(3):607-11
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  • [Title] Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene.
  • In the present study, we have addressed the role of PPARbeta and PPARgamma in lung tumorigenesis in a transgenic mouse model of RAF-induced lung adenoma using two different strategies: i) crossing with PPARbeta null mice, and ii) chronic treatment with the PPARgamma agonist rosiglitazone.
  • These observations indicate i) that RAF-induced lung tumorigenesis is attenuated in mice with a disrupted Pparb gene, and ii) that chronic PPARgamma activation does not affect lung adenoma growth.
  • [MeSH-major] Adenoma / genetics. Gene Expression Regulation, Neoplastic. Lung Neoplasms / genetics. PPAR delta / genetics. PPAR-beta / genetics. Proto-Oncogene Proteins c-raf / genetics


46. Xie XY, Shen J, Xu LY, Li EM, Shen ZY: Bronchogenic and alveologenic tumors in mice induced by N-nitrosopiperidine. Biochem Cell Biol; 2010 Aug;88(4):775-82
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  • The aim of this study was to explore the histogenesis and carcinogenesis of pulmonary cancer induced by N-nitrosopiperidine (NPIP) in mice.
  • Pulmonary tissues and tumors in the NPIP-treated group were examined by light microscopy and transmission electron microscopy and compared with the control group at 4-week intervals.
  • Twenty-two mice in the experimental group were found to develop pulmonary tumors, but none in the control group.
  • The expression of p53, bcl-2, c-myc, ras, and the subunits of telomerase were found to increase in all pulmonary tissues and tumors formed thereafter upon NPIP treatment.
  • In summary, NPIP-induced mouse lung tumors exhibited morphological changes during carcinogenesis, which may be the consequence of overexpression of some genes associated with the development of carcinoma and changes in subunits of telomerase.
  • This mouse model of lung tumor formation may be a useful tool to delineate the histogenesis and carcinogenesis of human pulmonary cancer.
  • [MeSH-major] Carcinoma, Bronchogenic / chemically induced. Lung Neoplasms / chemically induced. Nitrosamines
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / genetics. Adenoma / pathology. Adenoma / ultrastructure. Animals. Carcinoma, Squamous Cell / chemically induced. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / ultrastructure. Female. Gene Expression Regulation, Neoplastic. Genes, bcl-2. Genes, myc. Genes, p53. Genes, ras. Male. Mice. Mice, Inbred BALB C. Pulmonary Alveoli / drug effects. Pulmonary Alveoli / metabolism. Pulmonary Alveoli / pathology. Pulmonary Alveoli / ultrastructure. Telomerase / genetics. Telomerase / metabolism

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  • (PMID = 20651851.001).
  • [ISSN] 1208-6002
  • [Journal-full-title] Biochemistry and cell biology = Biochimie et biologie cellulaire
  • [ISO-abbreviation] Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Nitrosamines; 6N066XUL4L / N-nitrosopiperidine; EC 2.7.7.49 / Telomerase; EC 2.7.7.49 / Tert protein, mouse
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47. Papla B: Papillary adenoma of the lung. Pol J Pathol; 2009;60(1):49-51
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  • [Title] Papillary adenoma of the lung.
  • The report presents a very rare case of papillary adenoma of the lung in a 61-year old man, described for the first time in the Polish literature.
  • [MeSH-major] Adenoma / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Humans. Keratins / metabolism. Male. Middle Aged. Pulmonary Surfactant-Associated Protein A / metabolism. Respiratory Mucosa / metabolism. Respiratory Mucosa / pathology

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  • (PMID = 19670704.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Pulmonary Surfactant-Associated Protein A; 68238-35-7 / Keratins
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48. Molino C, Fabbian F, Russo G, Cantelli S, Bortot A, Galdi A, Catizone L: [MEN type 1 and chronic renal failure: a rarely reported association]. G Ital Nefrol; 2007 Jan-Feb;24(1):79-82
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  • CASE: A 70-year-old Caucasian female patient had a history of primitive hyperparathyroidism, prolactinoma, glucagonoma, adrenal adenoma and pulmonary neuroendocrine neoplasia.

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  • (PMID = 17342698.001).
  • [ISSN] 0393-5590
  • [Journal-full-title] Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
  • [ISO-abbreviation] G Ital Nefrol
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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49. Kaspareit J, Friderichs-Gromoll S, Buse E, Habermann G: Spontaneous neoplasms observed in cynomolgus monkeys (Macaca fascicularis) during a 15-year period. Exp Toxicol Pathol; 2007 Nov;59(3-4):163-9
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  • Most of the tumors (22) in the cynomolgus monkeys were seen in endocrine organs (adrenal cortical adenoma, adrenal hemangioma, C-cell carcinoma, follicular adenoma), respiratory system (nasal cavity adenoma, pulmonary squamous cell carcinoma, bronchio-alveolar carcinoma, bronchiolar papilloma, chondromatous hamartoma) and female genital system (uterine polyp, uterine adenoma, uterine leiomyoma and teratoma of the ovary).

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  • (PMID = 17869495.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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50. Hong HH, Houle CD, Ton TV, Sills RC: K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. Toxicol Pathol; 2007 Jan;35(1):81-5
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  • [Title] K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
  • In 2-year mouse studies, ethylene oxide (EO) induced lung, Harderian gland (HG), and uterine neoplasms.
  • K-ras mutations were identified in 100% (23/23) of the EO-induced lung neoplasms and 25% (27/108) of the spontaneous lung neoplasms.
  • Codon 12 G to T transversions were common in EO-induced lung neoplasms (21/23) but infrequent in spontaneous lung neoplasms (1/108).
  • These data show a strong predilection for development of K-ras mutations in EO-induced lung, Harderian gland, and uterine neoplasms.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Carcinogens / toxicity. Ethylene Oxide / toxicity. Genes, ras. Lung Neoplasms / genetics. Sebaceous Gland Neoplasms / genetics. Uterine Neoplasms / genetics

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  • (PMID = 17325976.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / DNA, Neoplasm; 0 / Disinfectants; JJH7GNN18P / Ethylene Oxide
  • [Other-IDs] NLM/ NIHMS33464; NLM/ PMC2099306
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51. Sugi O, Kimata N, Miwa N, Otsubo S, Nitta K, Akiba T: Successful cinacalcet treatment of refractory secondary hyperparathyroidism due to multiple lung parathyroid adenomas. NDT Plus; 2010 Feb;3(1):60-3
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  • [Title] Successful cinacalcet treatment of refractory secondary hyperparathyroidism due to multiple lung parathyroid adenomas.
  • Computed tomography scan indicated the presence of multiple ectopic lung nodules and 26 nodules were surgically removed from the left lung.

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  • (PMID = 25984040.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4421561
  • [Keywords] NOTNLM ; cinacalcet / ectopic parathyroid adenoma / haemodialysis / hyperparathyroidism
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52. Yener S, Ertilav S, Secil M, Akinci B, Demir T, Comlekci A, Yesil S: Natural course of benign adrenal incidentalomas in subjects with extra-adrenal malignancy. Endocrine; 2009 Aug;36(1):135-40
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  • [MeSH-major] Adenoma / epidemiology. Adrenal Cortex Neoplasms / epidemiology. Cushing Syndrome / epidemiology. Neoplasms / epidemiology. Pheochromocytoma / epidemiology
  • [MeSH-minor] Adult. Aged. Carcinoma, Non-Small-Cell Lung / epidemiology. Carcinoma, Renal Cell / epidemiology. Disease Progression. Female. Follow-Up Studies. Humans. Incidental Findings. Kidney Neoplasms / epidemiology. Lung Neoplasms / epidemiology. Lymphoma, Non-Hodgkin / epidemiology. Male. Middle Aged. Pancreatic Neoplasms / epidemiology. Prevalence. Registries

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  • (PMID = 19381885.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. National Toxicology Program: Toxicology and carcinogenesis studies of dibromoacetic acid (Cas No. 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies). Natl Toxicol Program Tech Rep Ser; 2007 Apr;(537):1-320
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  • The incidences of multiple hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined) were significantly increased in all exposed groups of males and in 500 and 1,000 mg/L females.
  • The incidences of alveolar/bronchiolar adenoma occurred with positive trends in males and females, and the incidence in 500 mg/L male mice was significantly greater than that in controls.
  • Increased incidences of lung neoplasms in male mice were also considered to be exposure related.
  • The slight increased incidence of lung neoplasms in female mice may have been related to dibromoacetic acid exposure.
  • [MeSH-minor] Administration, Oral. Animals. Body Weight / drug effects. CHO Cells. Cricetinae. Cricetulus. Drug-Induced Liver Injury / etiology. Drug-Induced Liver Injury / pathology. Female. Kidney Diseases / chemically induced. Kidney Diseases / pathology. Liver / drug effects. Liver / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Lung Neoplasms / chemically induced. Lung Neoplasms / pathology. Male. Mesothelioma / chemically induced. Mesothelioma / secondary. Mice. Mice, Inbred Strains. Micronuclei, Chromosome-Defective / chemically induced. Organ Size / drug effects. Rats. Rats, Inbred F344. Salmonella typhimurium / drug effects. Salmonella typhimurium / genetics. Testis / drug effects. Testis / pathology. Water Supply

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  • (PMID = 17554398.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetates; 0 / Carcinogens; 0 / Environmental Pollutants; 0 / Mutagens; 631-64-1 / dibromoacetic acid
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54. Melnick RL, Nyska A, Foster PM, Roycroft JH, Kissling GE: Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice. Toxicology; 2007 Feb 12;230(2-3):126-36
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  • In the 2-year studies, neoplasms were induced at multiple sites in rats and mice exposed to DBA; these included mononuclear cell leukemia and abdominal cavity mesothliomas in rats, and neoplasms of the liver (hepatocellular adenoma or carcinoma and hepatoblastoma) and lung (alveolar adenoma or carcinoma) in mice.
  • [MeSH-minor] Administration, Oral. Animals. Carcinogenicity Tests. Female. Histocytochemistry. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Lung Neoplasms / chemically induced. Lung Neoplasms / pathology. Male. Mice. Mice, Inbred C57BL. Organ Size / drug effects. Rats. Rats, Inbred F344. Testicular Neoplasms / chemically induced. Testicular Neoplasms / pathology. Water Purification / methods

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  • (PMID = 17157429.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Acetates; 631-64-1 / dibromoacetic acid
  • [Other-IDs] NLM/ NIHMS17825; NLM/ PMC1905493
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55. Yoshino N, Kubokura H, Yamauchi S, Ohaki Y, Koizumi K, Shimizu K: A true pulmonary carcinosarcoma that required diagnostic differentiation from a pleomorphic adenoma: a case report. Ann Thorac Cardiovasc Surg; 2009 Feb;15(1):42-5
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  • [Title] A true pulmonary carcinosarcoma that required diagnostic differentiation from a pleomorphic adenoma: a case report.
  • Pulmonary carcinosarcoma is a rarely encountered tumor.
  • We treated a patient who had an intrabronchial polypoid lesion that required a diagnostic differentiation from epithelial-mesenchymal mixed neoplasms inclusive of pleomorphic adenoma, and that was diagnosed by immunohistochemical staining to be a true carcinosarcoma.
  • A 69-year-old man underwent left pneumonectomy in November 2000 with a diagnosis of atelectasis resulting from a tumor obstructing the left lower lobar bronchus, and also a lung abscess.
  • The tumor was initially diagnosed as pleomorphic adenoma, since it contained both benign-looking epithelial and mesenchymal elements, but immunohistochemical staining demonstrated myoglobin-positive rhabdomyosarcomatous elements along with cytokeratin-positive squamous cell carcinoma elements.
  • A definite diagnosis of pulmonary carcinosarcoma was confirmed.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinosarcoma / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Aged. Bronchoscopy. Diagnosis, Differential. Humans. Immunohistochemistry. Lung Abscess / etiology. Lung Abscess / pathology. Male. Pneumonectomy. Pulmonary Atelectasis / etiology. Pulmonary Atelectasis / pathology. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19262449.001).
  • [ISSN] 2186-1005
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Torabinezad S, Kumar PV, Hashemi SB, Rahimi A: Osteoclastomalike giant cell tumor of the parotid gland: report of a case with fine needle aspiration diagnosis. Acta Cytol; 2006 Jan-Feb;50(1):80-3
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  • The tumor has occurred rarely at many sites, such as thyroid, pancreas, soft tissue, breast, skin, heart, colon, lung, kidney, ovary and bladder.
  • CASE: A 35-year-old female presented with a mass in the left parotid gland clinically diagnosed as a pleomorphic adenoma.

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  • (PMID = 16514845.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Rajput R, Bhansali A, Dutta P, Gupta SK, Radotra BD, Bhadada S: Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. Pituitary; 2006;9(2):155-7
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  • [Title] Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung.
  • However, pituitary metastasis manifesting as bitemporal hemianopia as a presenting manifestation in a patient with silent adenocarcinoma of the lung, that too in a women, is quite uncommon.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Lung Neoplasms / diagnosis. Pituitary Neoplasms / diagnosis

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  • (PMID = 16832588.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
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  • [Language] eng
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58. Kosacka M, Wojtala R, Piesiak P, Passowicz-Muszyńska E, Jankowska R: [A case of kappa L-chain primary nodular lung amyloidosis]. Pol Merkur Lekarski; 2008 Dec;25(150):516-8
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  • [Title] [A case of kappa L-chain primary nodular lung amyloidosis].
  • We report a case of kappa L-chain primary lung amyloidosis.
  • After the quadrantectomy the breast tumor has been diagnosed as adenoma.
  • The diagnosis of pulmonary amyloidosis was established by an open lung biopsy.
  • The case illustrates the problems with diagnosis of multiple solitary nodules and the long and relatively benign course of primary pulmonary amyloidosis.
  • [MeSH-major] Amyloid / metabolism. Amyloidosis / diagnosis. Amyloidosis / metabolism. Immunoglobulin kappa-Chains / metabolism. Solitary Pulmonary Nodule / diagnosis. Solitary Pulmonary Nodule / metabolism
  • [MeSH-minor] Adult. Biomarkers / metabolism. Biopsy. Diagnosis, Differential. Female. Humans. Lung Neoplasms / diagnosis

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  • (PMID = 19205385.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Amyloid; 0 / Biomarkers; 0 / Immunoglobulin kappa-Chains
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59. Barnabei A, Ferretti E, Baldelli R, Procaccini A, Spriano G, Appetecchia M: Hurthle cell tumours of the thyroid. Personal experience and review of the literature. Acta Otorhinolaryngol Ital; 2009 Dec;29(6):305-11
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  • The prognosis of the malignant type of the tumour is still under debate as some Authors have reported that Hurthle cell adenoma occasionally behaves like Hurthle cell carcinoma.
  • From 1992 to 2003, the Authors identified 28 patients affected by Hurthle cell tumour, 9 with Hurthle cell adenoma and 19 with Hurthle cell carcinoma.
  • Mean age of patients affected by adenoma was 49.7 years (range 30-72) vs. 49.3 years (range 15-72) in Hurthle cell carcinoma patients.
  • Relapse was not observed in any of the cases with adenoma.
  • Only one Hurthle cell carcinoma patient showed distant lung metastases at 60 months' follow-up.
  • None of the patients with Hurthle cell adenoma showed a relapse or death caused by the tumour.

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  • (PMID = 20463834.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] Thyroid cancer, Hurthle cell
  • [Other-IDs] NLM/ PMC2868205
  • [Keywords] NOTNLM ; Hurthle cell adenoma / Hurthle cell carcinoma / Thyroid
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60. Mernitz H, Smith DE, Wood RJ, Russell RM, Wang XD: Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity. Int J Cancer; 2007 Apr 1;120(7):1402-9
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  • [Title] Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.
  • We examined 9cRA and 1,25D, alone and in combination, for their potential to inhibit carcinogen (NNK)-induced lung carcinogenesis in A/J mice.
  • Lung tumor incidence, tumor multiplicity, plasma 1,25D levels and kidney expression of vitamin D 24-hydroxylase (CYP24) were determined.
  • These data demonstrate that 9cRA and 1,25D, alone or combined, can inhibit lung tumor promotion in the A/J mouse model.
  • Combining 1,25D with 9cRA has the potential to mitigate the toxicity of 1,25D, while preserving the significant effect of 1,25D treatment against lung carcinogenesis.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Calcitriol / therapeutic use. Lung Neoplasms / prevention & control. Tretinoin / therapeutic use
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / metabolism. Adenoma / prevention & control. Animals. Carcinogens / toxicity. Cell Transformation, Neoplastic / drug effects. Dietary Supplements. Disease Models, Animal. Drug Therapy, Combination. Male. Mice. Mice, Inbred A. Nitrosamines / toxicity. Retinoid X Receptors / metabolism. Steroid Hydroxylases / metabolism. Vitamin D3 24-Hydroxylase. Vitamins / therapeutic use

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17205520.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01CA104932
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Carcinogens; 0 / Nitrosamines; 0 / Retinoid X Receptors; 0 / Vitamins; 5300-03-8 / alitretinoin; 5688UTC01R / Tretinoin; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; EC 1.14.- / Steroid Hydroxylases; EC 1.14.13.126 / Vitamin D3 24-Hydroxylase; FXC9231JVH / Calcitriol
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61. Jin HY, Park TS: Pulmonary pleomorphic adenoma: report of a rare case. Korean J Intern Med; 2007 Jun;22(2):122-4
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  • [Title] Pulmonary pleomorphic adenoma: report of a rare case.
  • Primary pleomorphic adenoma of the lung is a type of pulmonary adenoma that is extremely rare, and it predominantly occurs in the proximal airway.
  • We recently experienced a case of a peripheral solitary pulmonary nodule that was discovered on the CT scans.
  • We performed wedge resection with video-assisted thoracoscopic surgery and we firmly diagnosed this lesion as pulmonary pleomorphic adenoma according to the histology.
  • We report here on a rare benign tumor that was diagnosed as a primary pleomorphic adenoma located in the lung periphery.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 17616030.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2687611
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62. Kassie F, Kalscheuer S, Matise I, Ma L, Melkamu T, Upadhyaya P, Hecht SS: Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. Carcinogenesis; 2010 Feb;31(2):239-45
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  • [Title] Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice.
  • In previous studies, we reported that indole-3-carbinol (I3C) and myo-inositol (MI) inhibit lung adenoma induced by tobacco smoke carcinogens in A/J mice.
  • In this paper, we extended our work and examined the effects of I3C (70 or 30 micromol/g diet) and MI (56 micromol/g diet) against vinyl carbamate (VC)-induced lung adenocarcinoma by administering the agents from 1 week after the second of two injections of VC until termination of the study at week 18.
  • The higher dose of I3C decreased multiplicities of tumors on the surface of the lung (26%, P = 0.0005), carcinoma incidence (38%), multiplicity (67%, P < 0.0001) and size (complete abolition of carcinoma with an area of >1.0 cm(2)) as well as adenoma with cellular pleomorphism (46%, P < 0.0001).
  • MI decreased multiplicities of pulmonary surface tumors (20%, P = 0.0005), adenoma with cellular pleomorphism (40%, P < 0.0001) and lung adenoma (52%, P < 0.0001) and the proportion of the biggest carcinoma (carcinoma with an area of >1.0 cm(2), P < 0.05).
  • Immunoblot analyses of lung tissues for potential target identification showed that I3C (70 micromol/g diet) inhibits IkappaBalpha degradation, nuclear factor-kappaB activation, expression of cyclooxygenase-2, phospho-Akt and fatty acid synthase (FAS) and activates caspase-3 and poly ADP ribose polymerase cleavage.
  • Our data show that I3C and MI inhibit lung carcinoma and provide a basis for future evaluation of these compounds in clinical trials as chemopreventive agents for current and former smokers.

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  • (PMID = 19625346.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-102502
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Indoles; 12001-76-2 / Vitamin B Complex; 3IN71E75Z5 / Urethane; 4L6452S749 / Inositol; 7Y2431GOM5 / vinyl carbamate; C11E72455F / indole-3-carbinol; EC 1.14.99.1 / Cyclooxygenase 2; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspase 3
  • [Other-IDs] NLM/ PMC2812566
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63. Kobayashi M, Nakano K, Nukui A, Goto K, Morita T: Bilateral massive renal angiomyolipoma concurrent with oncocytoma in tuberous sclerosis complex associated with pulmonary lymphangioleiomyomatosis. Urology; 2008 Oct;72(4):948.e7-9
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  • [Title] Bilateral massive renal angiomyolipoma concurrent with oncocytoma in tuberous sclerosis complex associated with pulmonary lymphangioleiomyomatosis.
  • We describe a patient with tuberous sclerosis complex and massive bilateral renal angiomyolipomas (AMLs) in association with pulmonary lymphangioleiomatosis, who experienced hemorrhagic shock because of rupture of the left renal AML.
  • This case also represents a rare, but significant, overlap between renal AML, pulmonary lymphangioleiomatosis, and tuberous sclerosis complex.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Angiomyolipoma / complications. Kidney Neoplasms / complications. Lung Neoplasms / complications. Lymphangioleiomyomatosis / complications. Neoplasms, Multiple Primary / complications. Tuberous Sclerosis / complications


64. Purdue MP, Mink PJ, Hartge P, Huang WY, Buys S, Hayes RB: Hormone replacement therapy, reproductive history, and colorectal adenomas: data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (United States). Cancer Causes Control; 2005 Oct;16(8):965-73
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  • [Title] Hormone replacement therapy, reproductive history, and colorectal adenomas: data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial (United States).
  • OBJECTIVE: Findings from some epidemiologic studies of colorectal cancer and adenoma suggest that the protective effect of post-menopausal hormone replacement therapy (HRT) may differ across categories of age and body mass index (BMI).
  • We conducted an analysis of women participating in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial to investigate the relationship between HRT use and prevalent adenoma, both overall and across different population subgroups.
  • We identified 1468 women with at least one left-sided adenoma and 19,203 without adenoma or colorectal cancer.
  • RESULTS: Compared to never use of HRT, current use was associated with a decreased prevalence of left-sided adenoma (odds ratio (OR) 0.85; 95% confidence interval (CI) 0.75-0.97).
  • Other reproductive factors were not significantly associated with adenoma prevalence.
  • CONCLUSIONS: Our findings suggest that current HRT use may protect against colorectal adenoma, and that this protective effect is short-lived following cessation of use.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / epidemiology. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Hormone Replacement Therapy / utilization. Mass Screening / statistics & numerical data


65. Kilic D, Findikcioglu A, Sahin E, Bilen A, Bakiner O, Hatipoglu A: Bilateral trapped lung with concomitant Wermer's syndrome and cutis laxa. Thorac Cardiovasc Surg; 2008 Dec;56(8):496-7
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  • [Title] Bilateral trapped lung with concomitant Wermer's syndrome and cutis laxa.
  • We report a rare occurrence of trapped lung associated with Wermer's syndrome and cutis laxa.
  • A 25-year-old man with bilateral trapped lung presented with respiratory distress.
  • Additional investigation revealed adenoma of the parathyroid and hypophysis, a neuroendocrine abdominal tumor, and cutis laxa.
  • Octreotide therapy was initiated and a percutaneous ultrasound-guided alcohol injection to the parathyroid adenoma was done.
  • [MeSH-major] Cutis Laxa / complications. Lung / pathology. Multiple Endocrine Neoplasia Type 1 / complications

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  • (PMID = 19012220.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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66. Licchesi JD, Westra WH, Hooker CM, Herman JG: Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. Clin Cancer Res; 2008 May 1;14(9):2570-8
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  • [Title] Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung.
  • The recognition of an early form of glandular neoplasia termed atypical adenomatous hyperplasia (AAH), a precursor lesion from which lung adenocarcinomas arise, provides an opportunity for characterizing early epigenetic alterations involved in lung tumorigenesis.
  • EXPERIMENTAL DESIGN: We evaluated AAHs, adjacent normal lung tissue, and synchronous lung adenocarcinomas for promoter hypermethylation of genes implicated in lung tumorigenesis (p16, TIMP3, DAPK, MGMT, RARbeta, RASSF1A, and hTERT).
  • CONCLUSION: This study shows epigenetic progression in the earliest stages of glandular neoplasia of the lung and has implications for early lung cancer detection.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. DNA Methylation. Genes, Neoplasm. Lung Neoplasms / genetics. Precancerous Conditions / genetics. Promoter Regions, Genetic
  • [MeSH-minor] Epigenesis, Genetic. Humans. Hyperplasia. Lung / metabolism. Lung / pathology

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  • (PMID = 18451218.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA058184
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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67. Herszényi L, Farinati F, Cardin R, István G, Molnár LD, Hritz I, De Paoli M, Plebani M, Tulassay Z: Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer. BMC Cancer; 2008;8:194
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Villous / genetics. Biomarkers, Tumor / blood. Colorectal Neoplasms / genetics

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  • (PMID = 18616803.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; EC 3.4.- / Cathepsins; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.1 / Cathepsin B; EC 3.4.22.15 / CTSL1 protein, human; EC 3.4.22.15 / Cathepsin L
  • [Other-IDs] NLM/ PMC2474636
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68. Galbiati F, Pettinicchio A, Dragani TA, Manenti G: Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines. Cancer Lett; 2006 Dec 8;244(2):176-81
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  • [Title] Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines.
  • Four of the six genes constituting the mouse Pulmonary adenoma susceptibility 1 (Pas1) locus haplotype carry amino acid variants: Lrmp, Casc1, Ghiso, and Lmna-rs1.
  • In vitro colony formation assay of human lung cancer cell lines A549 and NCI-H520 transfected with the allelic variants of the four genes revealed allele-specific modulations of colony numbers by Lmna-rs1 and Casc1, but not by Lrmp or Ghiso.
  • [MeSH-major] Adenoma / genetics. Alleles. Genetic Predisposition to Disease. Lung Neoplasms / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Animals. Apoptosis. Carcinoma, Non-Small-Cell Lung / genetics. Cells, Cultured. Colony-Forming Units Assay. Gene Expression Regulation, Neoplastic. Humans. Kidney / metabolism. Male. Membrane Proteins / genetics. Mice. Mice, Inbred A. Mice, Inbred C57BL. Microscopy, Fluorescence. Poly(ADP-ribose) Polymerases / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Transfection

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  • (PMID = 16458428.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Las1 protein, mouse; 0 / Lmna-rs1 protein, mouse; 0 / Lrmp protein, mouse; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Tumor Suppressor Proteins; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases
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69. Mizoi M, Takabayashi F, Nakano M, An Y, Sagesaka Y, Kato K, Okada S, Yamanaka K: The role of trivalent dimethylated arsenic in dimethylarsinic acid-promoted skin and lung tumorigenesis in mice: tumor-promoting action through the induction of oxidative stress. Toxicol Lett; 2005 Aug 14;158(2):87-94
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  • [Title] The role of trivalent dimethylated arsenic in dimethylarsinic acid-promoted skin and lung tumorigenesis in mice: tumor-promoting action through the induction of oxidative stress.
  • We investigated the relationship between lung- and skin-tumor promotion and oxidative stress caused by administration of dimethylarsinic acid (DMA(V)) in mice.
  • The incidence of lung tumors induced by lung tumor initiator (4NQO) and DMA(V) were, as well as 8-oxo-2'-deoxyguanosine (8-oxodG), suppressed by cotreatment with (-)epigallocatechin gallate (EGCG).
  • [MeSH-major] Adenoma / chemically induced. Cacodylic Acid / analogs & derivatives. Cacodylic Acid / toxicity. Carcinogens / toxicity. Herbicides / toxicity. Lung Neoplasms / chemically induced. Oxidative Stress / drug effects. Skin Neoplasms / chemically induced

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  • (PMID = 16039397.001).
  • [ISSN] 0378-4274
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Herbicides; 0 / dimethylarsinous acid; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; AJ2HL7EU8K / Cacodylic Acid; G9481N71RO / Deoxyguanosine
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70. Ozlem Küçük N, Kulak H, Tokmak E, Tar P, Ibiş E, Aras G: Hürthle cell carcinoma: a clinicopathological study of thirteen cases. Nucl Med Commun; 2006 Apr;27(4):377-9
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  • Distant metastases were detected in only one patient (lung metastasis).
  • A second dose of radioiodine therapy was required in only one patient who had lung metastases and this patient is still being followed up.
  • [MeSH-major] Adenoma, Oxyphilic / radiotherapy. Adenoma, Oxyphilic / surgery. Iodine Radioisotopes / therapeutic use. Neoplasm Recurrence, Local / prevention & control. Thyroid Neoplasms / radiotherapy. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 16531925.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Radiopharmaceuticals
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71. Machado MC, de Sa SV, Domenice S, Fragoso MC, Puglia P Jr, Pereira MA, de Mendonça BB, Salgado LR: The role of desmopressin in bilateral and simultaneous inferior petrosal sinus sampling for differential diagnosis of ACTH-dependent Cushing's syndrome. Clin Endocrinol (Oxf); 2007 Jan;66(1):136-42
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  • Ectopic ACTH-producing tumours (three lung carcinoid tumour, one thymus carcinoid tumour and one thymus hyperplasia) were confirmed in five out of nine patients without the CEN:PER ACTH gradient, and four cases were false negative for Cushing's disease.
  • [MeSH-minor] ACTH Syndrome, Ectopic / blood. ACTH Syndrome, Ectopic / diagnosis. ACTH Syndrome, Ectopic / surgery. Adenoma / blood. Adenoma / diagnosis. Adenoma / surgery. Adolescent. Adult. Diagnosis, Differential. Female. Humans. Hydrocortisone / blood. Male. Middle Aged. Pituitary Neoplasms / blood. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery. Retrospective Studies. Statistics, Nonparametric. Stimulation, Chemical

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  • (PMID = 17201813.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9002-60-2 / Adrenocorticotropic Hormone; ENR1LLB0FP / Deamino Arginine Vasopressin; WI4X0X7BPJ / Hydrocortisone
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72. Sharon E, Kelly RJ, Szabo E: Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine. Head Neck Oncol; 2010;2:12
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  • [Title] Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine.
  • BACKGROUND: Carcinoma ex pleomorphic adenoma is a rare histologic subtype of salivary gland cancer with an overall poor prognosis.
  • We report here a case of a 58-year old man with metastatic carcinoma ex pleomorphic adenoma who achieved a sustained long term response to combination therapy with trastuzumab and capecitabine.
  • CASE PRESENTATION: A 58 year old man presented with T1N2bM0 carcinoma ex pleomorphic adenoma and underwent surgery followed by adjuvant radiation therapy.
  • CONCLUSION: This case illustrates the successful long term treatment of carcinoma ex pleomorphic adenoma with targeted therapy with trastuzumab in combination with chemotherapy.
  • In the absence of definitive clinical trials which are unlikely to be performed due to the rarity of this tumor, case reports such as this one suggest potential utility for trastuzumab in combination with chemotherapy in the treatment of HER2/neu-overexpressing carcinoma ex pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Salivary Gland Neoplasms / drug therapy

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  • (PMID = 20504363.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; EC 2.7.10.1 / Receptor, ErbB-2; P188ANX8CK / Trastuzumab; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC2889991
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73. Magalhães E, Eugénio L, Bernardo J, Carvalho L, Antunes M: [Pleomorphic adenoma of the trachea. Case report]. Rev Port Pneumol; 2006 Mar-Apr;12(2):177-84
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  • [Title] [Pleomorphic adenoma of the trachea. Case report].
  • [Transliterated title] Adenoma pleomórfico da traqueia. Caso clínico.
  • The authors present a case of a pleomorphic adenoma of the trachea, diagnosed during the clinical evaluation of a suspected COPD or lung cancer in a heavy smoker patient with a positive family history of oncologic diseases.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Tracheal Neoplasms / surgery

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  • (PMID = 16804633.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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74. Wang F, Li HM, Chen XF, Xie KC, Huang Q: Low dosage 5-fluorouracil increases the transfection efficiency of Ad/VEGF-A in mouse lung carcinoma cell line LA795 and inhibits tumor growth. Chin J Cancer; 2010 Jul;29(7):677-82
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  • [Title] Low dosage 5-fluorouracil increases the transfection efficiency of Ad/VEGF-A in mouse lung carcinoma cell line LA795 and inhibits tumor growth.
  • We used adenovirus vector to transfer small interfering RNA (siRNA) against vascular epithelium growth factor A (VEGF-A) molecules to mouse lung adenoma LA795 cells and used low dose of chemotherapeutic drugs to further elevate the infection efficiency of adenovirus vector in and therapeutic effect of RNAi on tumor cells.
  • [MeSH-major] Cell Proliferation. Fluorouracil / pharmacology. Lung Neoplasms / pathology. RNA, Small Interfering / genetics. Vascular Endothelial Growth Factor A / genetics

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  • (PMID = 20591220.001).
  • [ISSN] 1000-467X
  • [Journal-full-title] Chinese journal of cancer
  • [ISO-abbreviation] Chin J Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Vascular Endothelial Growth Factor A; U3P01618RT / Fluorouracil
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75. DeWitt J, Alsatie M, LeBlanc J, McHenry L, Sherman S: Endoscopic ultrasound-guided fine-needle aspiration of left adrenal gland masses. Endoscopy; 2007 Jan;39(1):65-71
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  • RESULTS: Our searches resulted in the identification of a series of 38 consecutive patients who underwent EUS for the evaluation of a lung mass (n = 14), a pancreatic mass (n = 14), obstructive jaundice (n = 1), dysphagia (n = 2), an ampullary adenoma (n = 1), celiac block (n = 1), or a left adrenal gland mass (n = 5).
  • Diagnoses after EUS-FNA (the mean number of passes was 3.6) were: metastatic lung cancer (n = 2), esophageal adenocarcinoma (n = 1), melanoma (n = 1), renal cell carcinoma (n = 1), and pancreatic neuroendocrine tumor (n = 1); primary pheochromocytoma (n = 1); benign adrenal tissue (n = 21); and granulomatous inflammation (n = 1).


76. Kang MS, Lu H, Yasui T, Sharpe A, Warren H, Cahir-McFarland E, Bronson R, Hung SC, Kieff E: Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. Proc Natl Acad Sci U S A; 2005 Jan 18;102(3):820-5
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  • EBNA1-transgenic lineages had a higher pulmonary adenoma prevalence than did littermate controls (39% versus 7%).
  • However, the adenoma prevalence was not higher in EBNA1-transgenic mice than has been described for FVB mice, and EBNA1 was not expressed in normal pulmonary epithelia or adenomas.

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  • (PMID = 15640350.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA047006; United States / NCI NIH HHS / CA / R35 CA047006; United States / NCI NIH HHS / CA / CA47006
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EBV-encoded nuclear antigen 1; 0 / Epstein-Barr Virus Nuclear Antigens; EC 3.1.3.48 / Antigens, CD45
  • [Other-IDs] NLM/ PMC545574
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77. Wang Q, Zhang P, Zhang Q, Wang X, Li J, Ma C, Sun W, Zhang L: Analysis of CD137 and CD137L expression in human primary tumor tissues. Croat Med J; 2008 Apr;49(2):192-200
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  • METHODS: Expression of CD137 and CD137L was assessed by immunohistochemistry in frozen sections of 12 human normal tissues, 15 benign tumors of epithelial or mesenchymal origin (adenoma and leiomyoma), and 36 malignant tumors of epithelial origin (squamous cell carcinoma and adenocarcinoma).
  • The expression of CD137L on 9 human tumor cell lines (3 hepatocarcinoma, 2 lung carcinoma, 2 colon carcinoma, 1 lymphoma, and 1 leukemia) was detected by reverse transcription polymerase chain reaction.
  • Furthermore, CD137L expression found on tumor cell lines was functional because the ligation of CD137L on lung squamous carcinoma cells L78 with CD137 on T cells induced IFN-gamma production by T cells, and ligation of CD137L on hepatocarcinoma cells HepG2.2.15 with CD137 triggered tumor cells to produce IL-8.

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  • [ISSN] 1332-8166
  • [Journal-full-title] Croatian medical journal
  • [ISO-abbreviation] Croat. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / 4-1BB Ligand; 0 / Antigens, CD137
  • [Other-IDs] NLM/ PMC2359873
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78. Erichsen HC, Peters U, Eck P, Welch R, Schoen RE, Yeager M, Levine M, Hayes RB, Chanock S: Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer; 2008;60(5):652-9
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  • [Title] Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma.
  • To investigate if common genetic variants in these two genes are associated with risk of colorectal tumor development, we conducted a case-control study of 656 Caucasian advanced distal colorectal adenoma cases and 665 Caucasian sigmoidoscopy-negative controls nested within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Organic Anion Transporters, Sodium-Dependent / genetics. Polymorphism, Genetic / genetics. Symporters / genetics

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  • (PMID = 18791929.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DK053211-01
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organic Anion Transporters, Sodium-Dependent; 0 / SLC23A1 protein, human; 0 / SLC23A2 protein, human; 0 / Sodium-Coupled Vitamin C Transporters; 0 / Symporters
  • [Other-IDs] NLM/ NIHMS356181; NLM/ PMC3490215
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79. Ricchetti T, Paci M, Cavazza A, Ferrari G, Annessi V, De Franco S, Sgarbi G: A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma. Tumori; 2005 Mar-Apr;91(2):210-2
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  • [Title] A case of metastatic epithelioid angiosarcoma in the lamina propria of a sigmoid tubulovillous adenoma.
  • It is generally a secondary tumor and the preferred sites of such metastases are the heart, pericardium, lung, breast, liver, spleen, bone, and brain.
  • In rare cases the lung has been described as the primary site.
  • We report a case of epithelioid angiosarcoma with multiple bilateral lung infiltration, bone metastasis, and metastasis of the lamina propria of a tubulovillous adenoma of the colon.
  • [MeSH-major] Adenoma / pathology. Basement Membrane / pathology. Epithelioid Cells / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secretion. Sigmoid Neoplasms / pathology

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  • (PMID = 15948556.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Platelet Endothelial Cell Adhesion Molecule-1
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80. Cody DD, Nelson CL, Bradley WM, Wislez M, Juroske D, Price RE, Zhou X, Bekele BN, Kurie JM: Murine lung tumor measurement using respiratory-gated micro-computed tomography. Invest Radiol; 2005 May;40(5):263-9
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  • [Title] Murine lung tumor measurement using respiratory-gated micro-computed tomography.
  • OBJECTIVE: The authors explored micro-computed tomography (micro-CT) to quantify lung tumor number and volume in a specific genetic mouse model for lung cancer.
  • MATERIALS AND METHODS: The authors used K-ras mice, which develop lung adenomas and adenocarcinomas through somatic activation of the K-ras oncogene.
  • Serial lung tumor volume was assessed in a pilot group (n = 8) of mice in vivo.
  • Lung tumor volume measurements were both reproducible (2% operator variability) and accurate (6% average error).
  • Micro-CT may become a powerful tool for murine lung cancer research in vivo.
  • [MeSH-major] Lung Neoplasms / radiography. Microradiography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenoma / pathology. Adenoma / radiography. Animals. Disease Models, Animal. Female. Male. Mice. Mice, Transgenic. Pilot Projects. Radiographic Image Enhancement. Reproducibility of Results. Respiration

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  • (PMID = 15829823.001).
  • [ISSN] 0020-9996
  • [Journal-full-title] Investigative radiology
  • [ISO-abbreviation] Invest Radiol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / P50 CA70907; United States / NCI NIH HHS / CA / R01 CA80686; United States / NCI NIH HHS / CA / U01 CA84306
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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81. Sharma S, Gao P, Steele VE: The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model. Carcinogenesis; 2006 Aug;27(8):1721-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model.
  • This study explored the efficacy of oltipraz, a dithiolthione to prevent lung cancer by delivering it directly to the lung as inhaled particulates to obtain maximum efficacy with no toxicity.
  • Two exposure regimens were used to compare the efficacies of early (Regimen-A) versus late (Regimen-B) intervention in prevention of lung tumorigenesis in A/J mice.
  • The spontaneous tumors were few in untreated A/J mice (0.7 tumors/lung), whereas there was an average of 16.5 tumors per lung in the B[a]P group (20-fold induction).
  • Evaluation of lung tumor multiplicity following exposure to oltipraz showed that oltipraz inhibited the tumor development in a dose-dependent manner (10-100 mg/m(3)) with inhibition ranging from 37 to 53% in Regimen A and 51% in Regimen B, when compared with the B[a]P group.
  • The data from this study show that oltipraz is an effective agent for lung cancer prevention, when it is delivered directly to the target tissue as aerosolized particulates.
  • [MeSH-major] Adenoma / prevention & control. Anticarcinogenic Agents / therapeutic use. Benzo(a)pyrene / toxicity. Lung Neoplasms / prevention & control. Pyrazines / therapeutic use

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  • (PMID = 16632869.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-25112
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Pyrazines; 3417WMA06D / Benzo(a)pyrene; 6N510JUL1Y / oltipraz
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82. Takei H, Buckleair L, Goodman JC, Powell SZ: Intraoperative cytologic diagnosis of symptomatic carcinoma (pulmonary small cell carcinoma) metastatic to the pituitary gland: a case report. Acta Cytol; 2007 Jul-Aug;51(4):637-41
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  • [Title] Intraoperative cytologic diagnosis of symptomatic carcinoma (pulmonary small cell carcinoma) metastatic to the pituitary gland: a case report.
  • It may masquerade as a pituitary adenoma both clinically and radiologically.
  • The initial radiologic diagnosis based on magnetic resonance imaging was pituitary adenoma.
  • While intraoperative frozen section examination could not completely exclude an "atypical" pituitary adenoma, cytologic touch imprint findings were diagnostic of metastatic small cell carcinoma.
  • Subsequently, additional workup revealed that the patient had a mass lesion in the right lung and right-sided mediastinal lymphadenopathy on chest computed tomography.
  • CONCLUSION: For intraoperative diagnosis at the time ofpituitary surgery, cytologic imprints can be used reliably to make a diagnosis not only of pituitary adenoma but also of metastatic lesions.
  • [MeSH-major] Carcinoma, Small Cell / diagnosis. Lung Neoplasms / diagnosis. Pituitary Neoplasms / secondary

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  • (PMID = 17718143.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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83. Nakamura H, Adachi Y, Arai T, Miwa K, Haruki T, Fujioka S, Taniguchi Y: A small alveolar adenoma resected by thoracoscopic surgery. Ann Thorac Surg; 2009 Mar;87(3):956-7
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  • [Title] A small alveolar adenoma resected by thoracoscopic surgery.
  • Alveolar adenoma (AA) is a rare lung benign tumor originated from type II pneumocytes.
  • It presents as a well-defined nodule in clinical images, but is difficult to differentiate from early-stage lung cancer.
  • We treated a 58-year-old woman with a small-sized AA measuring 8 x 6 mm in the upper lobe of the left lung by performing a thoracoscopic resection.
  • There have been no reported cases of recurrence after a resection of AA, but a subsequent increase in such cases is expected, and we believe that it is necessary to understand the characteristics of this typical benign lung tumor.
  • [MeSH-major] Adenoma / surgery. Lung Neoplasms / surgery. Thoracoscopy

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  • (PMID = 19231437.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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84. Kozakiewicz J, Teodorowicz E, Haczyńska-Partyka A, Myrcik G, Lange D, Szwabowicz M: [Adenoma oxyphillicum an extremely rare case of tumour of the larynx end cancer lungs which are going together]. Otolaryngol Pol; 2007;61(3):311-4
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  • [Title] [Adenoma oxyphillicum an extremely rare case of tumour of the larynx end cancer lungs which are going together].
  • There was presented an exstremely rare case of adenoma oxyphillicum of the larynx coexisting with the lung carcinoma.
  • It consisted such matters as detailed graphical examination, spliting of larynx, and radiotherapy and chemiotherapy of lung cancer.
  • The authors want to call attention to limited use fullness of competent lungs X-ray in a-p projection in recognizing the early stadium of lung cancer.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / surgery. Lung Neoplasms / radiography. Lung Neoplasms / therapy. Neoplasms, Second Primary / radiography. Neoplasms, Second Primary / therapy

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  • (PMID = 17847787.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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86. Cindolo L, Gidaro S, Neri F, Tamburro FR, Schips L: Assessing feasibility and safety of laparoendoscopic single-site surgery adrenalectomy: initial experience. J Endourol; 2010 Jun;24(6):977-80
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  • Pathology examination confirmed one adenoma, one lung cancer metastasis, and one myelolipoma.

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  • (PMID = 20367086.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology
  • [ISO-abbreviation] J. Endourol.
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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87. Kohno T, Kunitoh H, Suzuki K, Yamamoto S, Kuchiba A, Matsuno Y, Yanagitani N, Yokota J: Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias. Carcinogenesis; 2008 May;29(5):957-63
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  • [Title] Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias.
  • The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC).
  • In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1/LAS1 and LRMP, were examined in a hospital-based case-control study consisting of 364 lung ADC cases and 253 controls.
  • All the ADC cases were subjected to lobectomy and subsequent pathological investigation of atypical adenomatous hyperplasia (AAH), a putative precursor for peripheral lung ADC, including bronchioloalveolar carcinoma, in the resected lobes.
  • None of the 10 polymorphisms examined showed significant associations with overall lung ADC risk (P > 0.05).
  • Minor haplotypes including the minor allele for the KRAS-6 polymorphism showed increased ORs for ADC accompanied by multiple AAHs, and KRAS transcripts from the minor allele for this polymorphism were more abundantly detected in lung tissues than those from the major allele.
  • Thus, KRAS polymorphisms were indicated to be involved in risk for the development of AAHs that progress to ADC by causing differential KRAS oncogene expression in the lungs.
  • [MeSH-major] Adenocarcinoma / genetics. Lung Neoplasms / genetics. Polymorphism, Genetic. Polymorphism, Single Nucleotide. Proto-Oncogene Proteins / genetics. ras Proteins / genetics
  • [MeSH-minor] Adenomatosis, Pulmonary / epidemiology. Adenomatosis, Pulmonary / genetics. Aged. Antigens, Neoplasm / genetics. Antigens, Nuclear / genetics. DNA, Neoplasm / blood. DNA, Neoplasm / genetics. DNA, Neoplasm / isolation & purification. Female. Humans. Hyperplasia / complications. Hyperplasia / epidemiology. Hyperplasia / genetics. Japan / epidemiology. Male. Middle Aged. Risk Factors. Smoking / epidemiology

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  • (PMID = 18299280.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Antigens, Nuclear; 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / PASD1 protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / ras Proteins
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88. Okubo C, Morishita Y, Minami Y, Ishiyama T, Kano J, Iijima T, Noguchi M: Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Mol Carcinog; 2005 Feb;42(2):121-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phenotypic characteristics of mouse lung adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
  • The expression profile of adenoma induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice was compared with that of normal lung tissue by suppression subtractive hybridization (SSH).
  • The mRNAs of surfactant-associated protein A (SP-A) and lysozyme showed characteristically higher transcription in the adenoma tissue than in normal lung.
  • In normal lung, alveolar type II pneumocytes were positive for both SP-A and lysozyme, indicating that tumor cells retained the phenotypic characteristics of the murine alveolar type II pneumocytes.
  • Thus, the present results indicate that the phenotype of NNK-induced A/J mouse adenoma differs from that of AAH, which is thought to be a preinvasive lesion of human adenocarcinoma.
  • [MeSH-major] Adenoma / chemically induced. Adenoma / pathology. Carcinogens. Nitrosamines
  • [MeSH-minor] Animals. Apoproteins / metabolism. DNA, Complementary / metabolism. DNA-Directed RNA Polymerases / metabolism. Female. In Situ Hybridization. Lasers. Lung / cytology. Lung / pathology. Mice. Microscopy, Electron, Transmission. Muramidase / chemistry. Muramidase / metabolism. Phenotype. Promoter Regions, Genetic. Pulmonary Surfactant-Associated Protein A / metabolism. RNA / metabolism. RNA, Messenger / metabolism. Surface-Active Agents / metabolism. Time Factors. Viral Proteins

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  • [Copyright] Copyright 2004 Wiley-Liss, Inc.
  • (PMID = 15584020.001).
  • [ISSN] 0899-1987
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoproteins; 0 / Carcinogens; 0 / DNA, Complementary; 0 / Nitrosamines; 0 / Pulmonary Surfactant-Associated Protein A; 0 / RNA, Messenger; 0 / Surface-Active Agents; 0 / Viral Proteins; 63231-63-0 / RNA; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; EC 2.7.7.- / bacteriophage T7 RNA polymerase; EC 2.7.7.6 / DNA-Directed RNA Polymerases; EC 3.2.1.17 / Muramidase
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89. Kozakowski N, Soleiman A, Pammer J: BMI-1 expression is inversely correlated with the grading of renal clear cell carcinoma. Pathol Oncol Res; 2008 Mar;14(1):9-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Blotting, Western. Cell Line, Tumor. Disease Progression. Humans. Immunohistochemistry. Kidney / metabolism. Kidney / pathology. Neoplastic Stem Cells / metabolism. Polycomb Repressive Complex 1. Statistics, Nonparametric

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  • (PMID = 18347933.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / BMI1 protein, human; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; EC 2.3.2.27 / Polycomb Repressive Complex 1
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90. Sahdev A, Reznek RH, Evanson J, Grossman AB: Imaging in Cushing's syndrome. Arq Bras Endocrinol Metabol; 2007 Nov;51(8):1319-28
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  • Non-pituitary ectopic sources of ACTH, such as a small-cell lung carcinoma or carcinoid tumours, are the source of the remainder of ACTH-dependent disease.
  • [MeSH-major] ACTH-Secreting Pituitary Adenoma / diagnosis. Cushing Syndrome / diagnosis. Pituitary Gland / pathology. Pituitary Neoplasms / diagnosis
  • [MeSH-minor] ACTH Syndrome, Ectopic / diagnosis. Adenoma / diagnosis. Adenoma / radiography. Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / radiography. Carcinoma / diagnosis. Carcinoma / radiography. Humans. Hyperplasia / diagnosis. Hyperplasia / radiography. Lung Neoplasms / diagnosis. Lung Neoplasms / secretion. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 18209870.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 36
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91. Lee CI, Hsu MY, Chou CH, Wang C, Lo YS, Loh JK, Howng SL, Hong YR: CTNNB1 (beta-catenin) mutation is rare in brain tumours but involved as a sporadic event in a brain metastasis. Acta Neurochir (Wien); 2009 Sep;151(9):1107-11
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  • METHOD: We used polymerase chain reaction PCR and direct sequencing methods to investigate whether mutations in the CTNNB1 phosphorylation sites S33, S37, S41 and T45 were present in 68 brain tumours, including meningioma, astrocytoma, pituitary adenoma, neuroblastoma, metastasis to the brain, and cell lines.
  • However, a missense mutation of CTNNB1 was identified at residue 33, TCT (Ser) --> TGT (Cys) in a patient with lung metastasis to brain.
  • [MeSH-minor] Biomarkers, Tumor / genetics. Carcinoma / secondary. Catalytic Domain / genetics. Cell Line, Tumor. DNA Mutational Analysis. Exons / genetics. Gene Expression Regulation, Neoplastic / genetics. Gene Frequency. Genetic Markers. Genetic Testing. Humans. Lung Neoplasms / pathology. Phosphorylation. Signal Transduction / genetics. Transcriptional Activation / genetics. Wnt Proteins / genetics

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  • (PMID = 19582367.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Genetic Markers; 0 / Wnt Proteins; 0 / beta Catenin
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92. Nakanishi K, Kumaki F, Hiroi S, Mukai M, Ikeda E, Kawai T: Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Arch Pathol Lab Med; 2006 Sep;130(9):1330-4
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  • [Title] Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
  • CONCLUSIONS: On this basis, we suggest that the part played by Mre11 in telomere maintenance may not be important for the progression of the adenoma-carcinoma (AAH-NMBAC) sequence in the lung, although some role for it in carcinogenesis cannot be completely ruled out.
  • [MeSH-major] Adenocarcinoma / pathology. DNA-Binding Proteins / genetics. Lung Neoplasms / pathology
  • [MeSH-minor] Bronchial Neoplasms / genetics. Bronchial Neoplasms / pathology. Humans. Hyperplasia. Immunohistochemistry. Pulmonary Alveoli / pathology. RNA, Messenger / genetics. Retrospective Studies. Telomere / genetics

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  • (PMID = 16948520.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / MRE11A protein, human; 0 / RNA, Messenger
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93. Corbin K, Fisher S, Sahasrabudhe D, Pandya K, Brasacchio R, Constine LS: Five tumors over six years in eighth decade of life. Cancer Invest; 2008 Jul;26(6):634-7
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  • [MeSH-minor] Abdominal Neoplasms / etiology. Adenocarcinoma / etiology. Adenoma / etiology. Aged. Carcinoid Tumor / etiology. Humans. Lung Neoplasms / etiology. Male. Pituitary Neoplasms / etiology. Prostatic Neoplasms / etiology. Risk Assessment. Risk Factors

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  • (PMID = 18584355.001).
  • [ISSN] 1532-4192
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Sweet-Cordero A, Tseng GC, You H, Douglass M, Huey B, Albertson D, Jacks T: Comparison of gene expression and DNA copy number changes in a murine model of lung cancer. Genes Chromosomes Cancer; 2006 Apr;45(4):338-48
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  • [Title] Comparison of gene expression and DNA copy number changes in a murine model of lung cancer.
  • Activation of oncogenic Kras in murine lung leads to the development of numerous small adenomas, only some of which progress over time to overt adenocarcinoma.
  • Thus, although Kras is the initiating oncogene, it is likely that secondary genetic events are required for progression from adenoma to adenocarcinoma.
  • Some of these secondary events may also be important in human lung adenocarcinoma.
  • [MeSH-major] Disease Models, Animal. Gene Dosage. Lung Neoplasms / genetics

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  • (PMID = 16323170.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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95. Matsumoto M, Umeda Y, Senoh H, Suzuki M, Kano H, Katagiri T, Aiso S, Yamazaki K, Arito H, Nagano K, Yamamoto S, Matsushima T: Two-year feed study of carcinogenicity and chronic toxicity of ortho-chloronitrobenzene in rats and mice. J Toxicol Sci; 2006 Aug;31(3):247-64
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  • Metastasis from mouse malignant liver tumors occurred predominantly in the lung.
  • [MeSH-minor] Adenoma / chemically induced. Animals. Body Weight / drug effects. Chronic Disease. Dose-Response Relationship, Drug. Eating / drug effects. Female. Kidney Diseases / chemically induced. Kidney Neoplasms / chemically induced. Male. Maximum Tolerated Dose. Mice. Organ Size / drug effects. Rats. Rats, Inbred F344

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  • (PMID = 16960435.001).
  • [ISSN] 0388-1350
  • [Journal-full-title] The Journal of toxicological sciences
  • [ISO-abbreviation] J Toxicol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Nitrobenzenes; 88-73-3 / 2-chloronitrobenzene
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96. Flood A, Peters U, Jenkins DJ, Chatterjee N, Subar AF, Church TR, Bresalier R, Weissfeld JL, Hayes RB, Schatzkin A, Prostate, Lung, Colorectal, Ovarian (PLCO) Project Team: Carbohydrate, glycemic index, and glycemic load and colorectal adenomas in the Prostate, Lung, Colorectal, and Ovarian Screening Study. Am J Clin Nutr; 2006 Nov;84(5):1184-92
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  • [Title] Carbohydrate, glycemic index, and glycemic load and colorectal adenomas in the Prostate, Lung, Colorectal, and Ovarian Screening Study.
  • DESIGN: We included subjects with no prior adenoma or cancer from the Prostate, Lung, Colorectal, and Ovarian screening trial and whose results from flexible sigmoidoscopy exams indicated either no lesions (n = 34 817) or >/=1 distal adenoma (n = 3696).
  • CONCLUSION: Despite expectations that increasing glycemic load and glycemic index would increase the risk of adenoma, we observed no association in women and even an inverse association in men.
  • [MeSH-major] Adenoma / epidemiology. Colorectal Neoplasms / epidemiology. Dietary Carbohydrates / administration & dosage. Food Habits

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  • (PMID = 17093173.001).
  • [ISSN] 0002-9165
  • [Journal-full-title] The American journal of clinical nutrition
  • [ISO-abbreviation] Am. J. Clin. Nutr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K07-CA108910-01A1
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Carbohydrates
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97. Diederich S: Pulmonary nodules: do we need a separate algorithm for non-solid lesions? Cancer Imaging; 2009;9 Spec No A:S126-8
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  • [Title] Pulmonary nodules: do we need a separate algorithm for non-solid lesions?
  • This article describes the aetiology, epidemiology and clinical significance of incidental non-solid pulmonary nodules.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Algorithms. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenoma / radiography. Adult. Aged. Follow-Up Studies. Humans. Hyperplasia. Incidental Findings. Mass Screening. Middle Aged. Positron-Emission Tomography. Precancerous Conditions / diagnosis. Precancerous Conditions / radiography

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  • (PMID = 19965304.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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98. National Toxicology Program: Toxicology and carcinogenesis studies of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (Cas No. 57117-31-4) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 Sep;(525):1-198
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  • Pulmonary EROD was also significantly higher in all dosed groups compared to vehicle controls at 14, 31, and 53 weeks.
  • Determinations of PeCDF Concentrations in Tissues: The tissue disposition of PeCDF was analyzed in the liver, lung, fat, and blood of all animals at the 14-, 31-, and 53-week interim evaluations, and in 10 animals per group at the end of the 2-year study (105 weeks).
  • Measurable concentrations of PeCDF were not detected in fat or lung from vehicle control rats at any of the interim evaluations or at 105 weeks.
  • No measurable concentrations of PeCDF were detected in the lungs of vehicle controls or any of the dosed groups at 14 weeks or in the lungs of the vehicle control group at 31, 53, and 105 weeks, or the 6 ng/kg group at 31 and 53 weeks.
  • Mean levels of PeCDF in the liver, fat, lung, and blood in the 200 ng/kg group at the end of the 2-year study were 500 ng/g, 7.75 ng/g, 0.28 ng/g and 0.04 ng/mL, respectively.
  • In the stop-exposure group, PeCDF concentration in lung was comparable to levels observed in the 6 ng/kg group.
  • At 2 years, there were significant dose-dependent trends for increased incidences of hepatocellular adenoma and cholangiocarcinoma of the liver.
  • At 14-weeks, lung weights were significantly increased in the 200 ng/kg group compared to the vehicle controls.
  • A single occurrence of a multiple cystic keratinizing epithelioma of the lung was observed in the 200 ng/kg core study group.
  • One pancreatic acinar adenoma and one pancreatic acinar carcinoma were each observed in the 92 ng/kg group and in the 200 ng/kg stop-exposure group at 2 years.

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  • (PMID = 17160103.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzofurans; 0 / Carcinogens; 0 / Thyroid Hormones; U4C2RV3124 / 2,3,4,7,8-pentachlorodibenzofuran
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99. Hunger-Battefeld W, Gajda M, Hansch A, Mandecka A, Müller UA, Wolf G: [Diagnostic pitfalls with Cushing's syndrome]. Internist (Berl); 2010 Mar;51 Suppl 1:293-302
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  • A histological differentiation between an adrenal cortical adenoma and carcinoma can be very difficult.
  • [MeSH-major] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Carcinoma, Renal Cell / diagnosis. Cushing Syndrome / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis
  • [MeSH-minor] Adrenal Cortex / pathology. Adrenalectomy. Circadian Rhythm / physiology. Diabetes Mellitus, Type 2 / etiology. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Hydrocortisone / blood. Hypertension / etiology. Kidney / pathology. Liver Neoplasms / pathology. Liver Neoplasms / secondary. Lung Neoplasms / pathology. Lung Neoplasms / secondary. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Obesity, Morbid / etiology. Weight Gain

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  • (PMID = 20012255.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
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100. Newman EM, Bouvet M, Borgehi S, Herold DA, Deftos LJ: Causes of hypercalcemia in a population of military veterans in the United States. Endocr Pract; 2006 Sep-Oct;12(5):535-41
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  • Lung carcinoma was the most prevalent malignant condition (in 17 patients or 29% of those with cancer).
  • A single parathyroid adenoma (in 20 of 22 patients who underwent surgical intervention) accounted for the majority of cases of primary hyperparathyroidism.

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  • (PMID = 17002928.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 27YLU75U4W / Phosphorus; 9007-12-9 / Calcitonin; 9NEZ333N27 / Sodium; AYI8EX34EU / Creatinine; FXC9231JVH / Calcitriol; SY7Q814VUP / Calcium
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