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1. Colović R, Grubor N, Radak V, Micev M, Colović N, Stojković M: [Tubular adenoma of the gallbladder with squamous metaplasia]. Srp Arh Celok Lek; 2006 Mar-Apr;134(3-4):159-61
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  • [Title] [Tubular adenoma of the gallbladder with squamous metaplasia].
  • Adenomas of the gallbladder are rare tumors.
  • Tubular adenoma appears in middle aged and older patients, although it may develop even in children.
  • This is a case report of forty-year old woman in whom a polypoid lesion was discovered in the gallbladder during regular ultrasonographic control after the liver surgery for hemangioma.
  • The gallbladder was removed during an open surgery.
  • A polypoid tumour of 20x7x5mm in size on wide pedicle was found in the gallbladder.
  • Histology showed tubular adenoma with mild epithelial dysplasia in some places and with antral and squamous metaplasia.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 16915759.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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2. Di Carlo I, Toro A, Pulvirenti E, Zisa M, Galia A: An unusual association of diffuse adenomyomatosis with dysplastic adenoma in chronic calculous cholecystitis: case presentation. BMC Gastroenterol; 2010;10:41
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  • [Title] An unusual association of diffuse adenomyomatosis with dysplastic adenoma in chronic calculous cholecystitis: case presentation.
  • BACKGROUND: Gallbladder adenomyomatosis is an epithelial proliferation and hypertrophy of the muscularis mucosae of the gallbladder.
  • The segmental adenomyomatosis has a higher risk of developing into gallbladder carcinoma, especially in the fundal region of elderly patients.We report the case of a patient affected by chronic calculous cholecystitis with diffuse adenomyomatosis associated with dysplastic adenoma.
  • The definitive pathological examination of the gallbladder showed: multiple stones of cholesterol origin; diffuse mucosal adenomyomatosis; and a 1.1 cm pedunculated mass localized at the fundus, whose surface was lumpy.
  • This mass was diagnosed as an adenoma with multiple areas of severe dysplasia.
  • CONCLUSIONS: The adenoma of the gallbladder, together with the dysplasia, represents a biological carcinogenetic model.
  • Degenerative risk suggests surgery should be mandatory when there is a concomitant presence of large adenoma and adenomyomatosis.
  • [MeSH-major] Adenoma / diagnosis. Adenomyoma / diagnosis. Cholecystitis / diagnosis. Gallbladder Neoplasms / diagnosis

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  • (PMID = 20423477.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2890701
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3. Lee SH, Lee DS, You IY, Jeon WJ, Park SM, Youn SJ, Choi JW, Sung R: [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder]. Korean J Gastroenterol; 2010 Feb;55(2):119-26
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  • [Title] [Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder].
  • BACKGROUND/AIMS: In order to determine the malignant potential of gallbladder adenoma for progression to carcinoma, we evaluated the histopathologic features of adenoma and adenoma-related lesions on cholecystectomized specimens.
  • A pathologist reviewed all specimens and selected benign adenomas, CIS in the adenoma, and adenoma residue in invasive carcinomas.
  • Adenomas and adenoma-related lesions were classified according to morphology (tubular, tubulopapillary, and papillary) and the consisting epithelium (biliary, pyloric metaplasia, and intestinal metaplasia).
  • The age and the size of the benign adenomas and carcinomas in the adenoma were also compared.
  • RESULTS: Adenoma and adenoma-related lesions were found in 34 out (1.8%) of all resected gallbladder.
  • Among 9 CIS and 28 invasive carcinomas, adenoma-related lesions were detected in 7 and 1 case, respectively.
  • All eight carcinomas arising in the adenoma were well-differentiated solitary tumors.
  • The diameters of the carcinomas in the adenoma were, on average, larger than that of the benign adenomas (1.8 cm vs. 0.9 cm, p=0.01).
  • The patients with carcinomas in the adenoma were, on average, older than those with benign adenomas, although the difference was insignificant (57 years vs. 47 years, p=0.09).
  • The morphology and consisting epithelium did not differ between the benign adenomas and carcinomas in the adenoma.
  • CONCLUSIONS: Gallbladder adenoma is a rare disease, although malignant transformation occurs frequently.
  • Adenoma is a precancerous lesion and the adenoma-carcinoma sequence is one of the gallbladder cancer carcinogenesis.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 20168058.001).
  • [ISSN] 2233-6869
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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4. Wani Y, Notohara K, Fujisawa M: Aberrant expression of an "intestinal marker" Cdx2 in pyloric gland adenoma of the gallbladder. Virchows Arch; 2008 Nov;453(5):521-7
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  • [Title] Aberrant expression of an "intestinal marker" Cdx2 in pyloric gland adenoma of the gallbladder.
  • The aim of this study was to survey Cdx2 expression in pyloric gland adenoma (PGA) of the gallbladder.
  • [MeSH-major] Adenoma / metabolism. Gallbladder Neoplasms / metabolism. Gastric Mucosa / metabolism. Homeodomain Proteins / metabolism

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  • (PMID = 18843504.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / beta Catenin
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5. Nonogaki K, Hirooka Y, Itoh A, Kawashima H, Hara K, Uchida H, Kasugai T, Ohno E, Ohmiya N, Niwa Y, Goto H: [A case of gallbladder adenoma with wide base]. Nihon Shokakibyo Gakkai Zasshi; 2008 Jan;105(1):74-80
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  • [Title] [A case of gallbladder adenoma with wide base].
  • A 65-year-old man was referred for a gallbladder elevated lesion.
  • Abdominal US showed a hypoechoic tumor with wide base at the gallbladder body.
  • The maximum velocity of the gallbladder wall blood flow was 20 cm/s.
  • We diagnosed the lesion as gallbladder carcinoma with the depth of subserosa.
  • Cholecystectomy was performed and the tumor was diagnosed as tubular adenoma of the gallbladder.
  • A gallbladder adenoma with wide base is rare, here we report this case with the several considerations.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • (PMID = 18176045.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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6. Ma HB, Hu HT, Di ZL, Wang ZR, Shi JS, Wang XJ, Li Y: Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. World J Gastroenterol; 2005 Feb 7;11(5):744-7
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  • [Title] Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma.
  • AIM: To investigate the role of cyclin D1, p16 and retinoblastoma in cancerous process of gallbladder carcinomas and to assess the relation between cyclin D1, p16, Rb and the biological characteristics of gallbladder carcinoma.
  • METHODS: Forty-one gallbladder carcinoma, 7 gallbladder adenoma and 14 chronic cholecystitis specimens were immunohistochemically and histopathologically investigated for the relation of cyclin D1, p16 and Rb with Nevin staging and pathologic grading.
  • RESULTS: The expression rates of abnormal cyclin D1 in gallbladder carcinoma (68.3%) and gallbladder adenoma (57.1%) were significantly higher than those in chronic cholecystitis (7.1%) (P<0.05).
  • No significant difference was found both among the pathological grades G(1), G(2) and G(3) and among Nevin stagings S(1)-S(2), S(3) and S(4)-S(5) of gallbladder carcinoma.
  • The positive rates of p16 (48.8%) and Rb (58.5%) in gallbladder carcinoma were significantly lower compared to those in adenoma (100.0%) and cholecystitis (100.0%) (P<0.05).
  • The positive rates of p16 and Rb in Nevin stagings S(1)-S(2) (80.0% and 90.0%) and S(3) (46.2% and 61.5%) gallbladder carcinomas were significantly higher than those in S(4)-S(5) (33.3% and 38.8%) (P<0.05), and those in pathologic grades G(1) (54.5% and 81.8%) and G(2) (50.0% and 62.5%) gallbladder carcinoma were significantly higher than those in G(3) (28.6% and 35.7%) (P<0.05).
  • The protein expression of p16 and Rb had a negative-correlation in gallbladder carcinoma (r = -0.2993, P<0.05), and this negative-correlation was correlated with Nevin staging (P<0.05).
  • Moreover, the protein expression of p16 and cyclin D1 had a negative-correlation in gallbladder carcinoma (r = -0.9417, P<0.05).
  • CONCLUSION: Cyclin D1 may play a role in the early stage of gallbladder carcinoma.
  • Mutation of p16 and Rb genes might be correlated with progression of gallbladder carcinoma.
  • Analysis of p16 and Rb can estimate the prognosis of gallbladder carcinoma.
  • Expression of p16 and Rb may be correlated with Nevin staging and pathologic grading in gallbladder carcinoma.
  • [MeSH-major] Adenoma / metabolism. Cyclin D1 / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Gallbladder Neoplasms / metabolism. Retinoblastoma Protein / metabolism


7. Wang SN, Chung SC, Tsai KB, Chai CY, Chang WT, Kuo KK, Chen JS, Lee KT: Aberrant p53 expression and the development of gallbladder carcinoma and adenoma. Kaohsiung J Med Sci; 2006 Feb;22(2):53-9
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  • [Title] Aberrant p53 expression and the development of gallbladder carcinoma and adenoma.
  • Gallbladder carcinoma (GBC) is a highly lethal but relatively rare neoplasm of the digestive tract.
  • The progression from gallbladder adenoma to carcinoma remains unclear.
  • In this study, we analyzed the expression patterns of the p53 protein in 22 cases of GBC, 17 cases of precursor lesions (16 gallbladder adenomas and 1 cystadenoma), and 15 cases of normal epithelia using immunohistochemical analysis.
  • We found that p53 expression was significantly increased in 59.1% (13/22) of GBC cases and in 17.6% (3/17) of gallbladder adenoma cases (p = 0.009).
  • [MeSH-major] Adenoma / chemistry. Gallbladder Neoplasms / chemistry. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16568721.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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8. Escalona A, León F, Bellolio F, Pimentel F, Guajardo M, Gennero R, Cruz JP, Viviani P, Ibáñez L: [Gallbladder polyps: correlation between ultrasonographic and histopathological findings]. Rev Med Chil; 2006 Oct;134(10):1237-42
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  • [Title] [Gallbladder polyps: correlation between ultrasonographic and histopathological findings].
  • BACKGROUND: Gallbladder polyps are becoming a common finding.
  • AIM: To analyze the ultrasonographic and histopathologic findings of patients operated due to gallbladder polyps.
  • PATIENTS AND METHODS: The records of patients with ultrasonographic diagnosis of gallbladder polyp and that underwent cholecystectomy in a thirteen years period were reviewed, collecting their demographic, ultrasonographic and histopathological data.
  • Four cases of adenoma (3.2%) were diagnosed; one of them had in situ carcinoma.
  • Polyp size was also a predictor of the presence of adenoma (p =0.043; confidence intervals: 1.006-1.424).
  • CONCLUSIONS: There is a good correlation between the size of the gallbladder polyp in ultrasonography and the size in the histopathology report.
  • Gallbladder adenoma is uncommon and it correlates with the size of the polyp.
  • In this series, size was the only predictor of the presence of adenoma.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology. Polyps / pathology

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  • (PMID = 17186092.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Chile
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9. Nakayama Y, Inoue H, Hamada Y, Takeshita M, Iwasaki H, Maeshiro K, Iwanaga S, Tani H, Ryu S, Yasunami Y, Ikeda S: Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases. Am J Surg Pathol; 2005 May;29(5):607-16
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  • [Title] Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases.
  • The intraductal tubular adenoma (ITA), pyloric gland type, of the pancreas is an uncommon benign tumor, akin to the pyloric gland type adenoma of the gallbladder.
  • In 2 cases, the adjacent pancreas showed foci of intraductal papillary-mucinous adenoma.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 15832084.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Mucins; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 9001-10-9 / Pepsinogen A
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10. Nagata S, Ajioka Y, Nishikura K, Watanabe G, Inoue T, Yamaguchi K, Watanabe H, Tanaka M, Tsuneyoshi M: Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: immunohistochemical analysis of mucin profile and CD10. Oncol Rep; 2007 Apr;17(4):721-9
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  • [Title] Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: immunohistochemical analysis of mucin profile and CD10.
  • Pyloric-gland type adenoma of the gallbladder is formed by proliferation of glands resembling pyloric glands, morphologically.
  • No previous report has described the cellular phenotype and differentiation of pyloric-gland type adenoma of the gallbladder, using CD10 as a marker of proper biliary phenotype.
  • Immunostainings were performed for mucin markers such as MUC5AC, human gastric mucin (HGM) for gastric foveolar type epithelium, MUC6, M-GGMC-1 for pyloric-gland type and MUC2 for intestinal goblet-cell type, and for CD10 as a proper biliary type marker on 58 pyloric-gland type adenomas of the gallbladder, as well as for p53, Ki-67 and CDX2.
  • Out of the 58 pyloric-gland type adenomas, >or=30% of adenoma cells were positive for MUC5AC in 22 (38%) tumors, HGM in 29 (50%), MUC6 in 58 (100%), M-GGMC-1 in 54 (93%), MUC2 in none (0%), and CD10 in 20 (34%).
  • MUC6 (P<0.001) and M-GGMC-1 (P<0.001) mucins were detected more frequently in pyloric-gland type adenomas, and CD10 expression was significantly decreased, compared with normal gallbladder epithelium (P=0.006).
  • In pyloric-gland type adenomas of the gallbladder, expression of pyloric-gland type mucins was observed with a high frequency, whereas intestinal goblet-cell mucins were rarely seen.
  • Pyloric-gland type adenomas of the gallbladder show a differentiation toward pyloric glands in terms of immunohistochemistry, as well as morphology, accompanied by co-expression of gastric foveolar and native biliary phenotypes.
  • [MeSH-major] Adenoma / chemistry. Adenoma / pathology. Gallbladder Neoplasms / chemistry. Gallbladder Neoplasms / pathology. Mucins / analysis. Neprilysin / analysis

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  • (PMID = 17342306.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Ki-67 Antigen; 0 / Mucins; 0 / Tumor Suppressor Protein p53; EC 3.4.24.11 / Neprilysin
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11. Turrini R, Lanzani G, Salmi A: [Gallbladder adenoma with focal adenocarcinoma: a case report]. Recenti Prog Med; 2007 Oct;98(10):506-8
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  • [Title] [Gallbladder adenoma with focal adenocarcinoma: a case report].
  • [Transliterated title] Adenoma con focale adenocarcinoma della colecisti: descrizione di un caso.
  • Gallbladder polyps represent a frequent and asymptomatic finding on abdominal sonography.
  • We describe the ultrasound features of an asymptomatic 13-mm gallbladder polyp in a 29-year-old male.
  • Video-laparoscopic cholecystectomy was performed, and histological examination of the lesion revealed a severely dysplastic tubular adenoma and chronic cholecystitis.
  • To our knowledge, this is the first report of a gallbladder polyp already presenting severe dysplasia in a young Caucasian male without risk factors.
  • [MeSH-major] Adenoma / diagnosis. Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / diagnosis. Polyps / complications
  • [MeSH-minor] Adult. Cholecystitis / complications. Cholecystitis / diagnosis. Cholecystitis / surgery. Chronic Disease. Humans. Male. Video-Assisted Surgery

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  • (PMID = 17970176.001).
  • [ISSN] 0034-1193
  • [Journal-full-title] Recenti progressi in medicina
  • [ISO-abbreviation] Recenti Prog Med
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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12. Ciurea S, Matei E, Petrisor P, Luca L, Boros M, Herlea V, Popescu I: Gallbladder adenoma with focal adenocarcinoma. Chirurgia (Bucur); 2008 May-Jun;103(3):355-8
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  • [Title] Gallbladder adenoma with focal adenocarcinoma.
  • The majority of polypoid lesions of the gallbladder are cholesterolosis pseudopolyps.
  • [MeSH-major] Adenocarcinoma. Adenoma. Gallbladder Neoplasms. Neoplasms, Multiple Primary

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  • (PMID = 18717288.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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13. Kumagai Y, Kotanagi H, Ishida H, Komatsuda T, Furukawa K, Yamada M, Ohuchi S, Seki H, Sakusabe M: Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings. Abdom Imaging; 2006 Jul-Aug;31(4):449-52
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  • [Title] Gallbladder adenoma: report of a case with emphasis on contrast-enhanced US findings.
  • There is a marked paucity of contrast-enhanced ultrasound (US) findings of gallbladder disease in the literature, and there is only one previous case of gallbladder adenoma.
  • US showed a 2-cm polypoid lesion at the gallbladder body.
  • The lesion was surgically resected, and was found to be an adenoma without cancer foci.
  • This case suggests that contrast-enhanced US is an effective tool in diagnosing a gallbladder adenoma.
  • [MeSH-major] Adenoma / ultrasonography. Gallbladder Neoplasms / ultrasonography

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  • (PMID = 16447086.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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14. Zhang L, Han F, Huang CS, Pang C, Han YZ, Hua YW: [Analysis of the treatment of unexpected gallbladder cancer]. Zhonghua Wai Ke Za Zhi; 2005 Apr 1;43(7):460-2
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  • [Title] [Analysis of the treatment of unexpected gallbladder cancer].
  • OBJECTIVE: To investigate the secondary operation methods and the effects on the prognosis of unexpected gallbladder cancer (UGC).
  • The 41 patients had undergone gallbladder excision because of cholecystitis complicated lithiasis of gallbladder (32 cases), polypi of gallbladder or adenoma (9 cases).
  • Postoperative pathology showed that 32 cases were adenocarcinoma of gallbladder, 6 cases were squamous carcinoma, 3 cases were squamous adenocarcinoma.
  • The second operation chose the improved method of Glenn excision of carcinoma of gallbladder.
  • RESULTS: On the second operation, 14 cases were with lymphatic metastasis, 14 with gallbladder metastasis, 6 with bile duct metastasis, 2 with pancreas metastasis.
  • [MeSH-major] Cholecystectomy / methods. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / surgery

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  • (PMID = 15854374.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Choi HJ, Yun SS, Kim HJ, Choi JH: Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. Hepatogastroenterology; 2010 Jan-Feb;57(97):18-21
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  • [Title] Expression of p16 protein in gallbladder carcinoma and its precancerous conditions.
  • BACKGROUND/AIMS: Adenocarcinoma of the gallbladder is a highly malignant neoplasm. p16 is a tumor suppressor gene protein, which is a cyclin-dependent kinase inhibitor that regulates the G1-S phase of the cell cycle.
  • The purpose of the present study was to investigate the expression of p16 in gallbladder carcinoma and its precancerous conditions and to examine the relationship between p16 expression and clinicopathological parameters.
  • METHODOLOGY: Formalin-fixed, paraffin-embedded tissue sections from 20 cases of normal gallbladder, 20 cases of chronic cholecystitis, 20 cases of gallbladder adenoma, 20 cases of dysplasia, and 58 cases of adenocarcinoma were examined.
  • RESULTS: In normal gallbladder, no expression of p16 was found.
  • In gallbladder adenomas, expression of p16 was found in 20% (4/20).
  • In gallbladder adenocarcinomas, p16 expression was found in 27.6% (16/58).
  • CONCLUSIONS: P16 protein overexpression is an early and relatively common event in carcinogenesis of gallbladder carcinoma.
  • Expression of p16 may be an ancillary diagnostic marker of gallbladder carcinoma and its precancerous conditions.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Cholecystitis / metabolism. Gallbladder Neoplasms / metabolism. Neoplasm Proteins / metabolism. Precancerous Conditions / metabolism

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  • (PMID = 20422865.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Neoplasm Proteins; 0 / P16 protein, human
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16. Lu HY, Zhang GQ, Li JC: [Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor]. Fen Zi Xi Bao Sheng Wu Xue Bao; 2006 Jun;39(3):249-57
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  • [Title] [Study on genetic instability of nm23H1 gene in Chinese with original gallbladder tumor].
  • The aim of this study was to examine the microsatellite instability (MSI) and loss of heterozygosity (LOH) of locus D17S396 on chromosome 17 and their influence on the expression of nm23H1 in gallbladder tumors, which may provide experimental basis for the tumor occurrence and metastasis.
  • In our experiment, the frequency of genetic instability of malignant gallbladder tumors was 42.55%, which was higher than that of gallbladder adenomas, while there were no genetic instability occurred in chronic cholecystitis tissue.
  • The frequency of LOH seemed higher with the deteriorism of gallbladder tumor.
  • Among 47 gallbladder carcinomas, the frequency of LOH and MSI were different between different differentiation cases (P < 0.05), and the frequency of LOH in liver and lymph node metastasis cases was significantly higher than those without metastasis (P < 0.01).
  • The expression of nm23H1 in gallbladder carcinoma, gallbladder adenoma and chronic cholecystitis tissue were different (P < 0.05).
  • In gallbladder carcinomas, the positive frequency of nm23H1 protein in LOH positive group was lower than that of LOH negative group (P < 0.05).
  • The results indicated that the genetic instability of nm23H1 gene might be implicated in pathogenesis and progression of gallbladder tumor.
  • Both MSI and LOH of nm23H1 gene controlled the development of gallbladder tumor independently in different paths.
  • MSI may be an early stage molecule marker of gallbladder carcinoma.
  • LOH may be molecule marker for the deteriorism of gallbladder tissue, which could inhibit the expression of nm23H1 in local tissue of gallbladder carcinoma and endow it with high aggressive and poor prognosis.
  • Increasing the amount of nm23H1 protein expression could effectively restrain gallbladder carcinoma metastasis and improve prognosis of patients.

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  • (PMID = 16944600.001).
  • [ISSN] 1673-520X
  • [Journal-full-title] Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology
  • [ISO-abbreviation] Fen Zi Xi Bao Sheng Wu Xue Bao
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / NM23 Nucleoside Diphosphate Kinases
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17. Biswas PK: Carcinoma gallbladder. Mymensingh Med J; 2010 Jul;19(3):477-81
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  • [Title] Carcinoma gallbladder.
  • Carcinoma gallbladder (CaGb) is a rare disease.
  • However the risk of CaGb is increased in anomalous pancreaticobiliary duct junction (APBDJ), gall stones, xanthogranulomatus cholecystitis, calcified or porcelain gallbladder, cholelithiasis with typhoid carriers, gallbladder adenoma, red meat consumption and tobacco uses.
  • In early carcinoma of a gallbladder sign and symptoms mimic benign disease.
  • The diagnosis is established by ultrasonography, computerized tomography and guided fine needle aspiration cytology (FNAC).
  • Biochemical tests are of very little value in making a diagnosis.
  • Prognosis depends on early diagnosis and appropriate surgical excision.

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  • (PMID = 20639849.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] Bangladesh
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18. Xu LN, Zou SQ, Wang JM: Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma. World J Gastroenterol; 2005 Jun 28;11(24):3719-23
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  • [Title] Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma.
  • AIM: To study the role of Fas and Fas ligand (FasL) in biological behaviors of gallbladder carcinoma, and their correlated action and mechanism in tumor escape.
  • METHODS: Streptavidin-biotin-peroxidase immunohistochemistry technique was used to study the expression of Fas and FasL protein in 26 gallbladder carcinoma tissues, 18 gallbladder adenoma tissues, 3 gallbladder dysplasia tissues and 20 chronic cholecystitis tissues.
  • Expression of both proteins and apoptosis of the tumor infiltrating lymphocytes in cancer tissues of primary foci was compared with clinicopathological features of gallbladder carcinoma.
  • RESULTS: The positive rates of Fas were not significantly different among carcinoma, adenoma, dysplasia and chronic cholecystitis.
  • The apoptotic index (AI) in carcinoma was significantly higher than that in adenoma (t' = 4.19, P<0.01) and chronic cholecystitis (t' = 8.06, P<0.01).
  • The confidence interval (CI) of infiltrating lymphocytes in adenoma, chronic cholecystitis, well-differentiated carcinoma and Nevin I-III carcinoma was very significantly lower than that in carcinoma (t' = 6.99, P<0.01), adenoma (t' = 3.66, P<0.01), poorly-differentiated carcinoma (t' = 5.31, P<0.01) and Nevin IV-V carcinoma (t' = 3.76, P<0.01), respectively.
  • Apoptosis of infiltrating lymphocytes was not discovered in adenoma and chronic cholecystitis.
  • CONCLUSION: FasL expressed in gallbladder carcinoma cells permits tumor cells to escape from immune surveillance of organism by inducing apoptosis in infiltrating lymphocytes of carcinoma tissues.
  • Up-regulation of FasL expression plays an important role in invasive depth, histological classification and metastasis of gallbladder carcinoma.
  • [MeSH-major] Adenoma / immunology. Antigens, CD95 / immunology. Gallbladder Neoplasms / immunology. Membrane Glycoproteins / immunology. Tumor Escape / physiology

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  • (PMID = 15968727.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins
  • [Other-IDs] NLM/ PMC4316023
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19. Scarpa MG, Gamba PG, Greggio NA, Chiarenza SF, Fasoli L, Musi L, Zanon GF: Polypoid lesion of the gallbladder in childhood: case report and literature review. Pediatr Med Chir; 2008 Jan-Feb;30(1):45-7
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  • [Title] Polypoid lesion of the gallbladder in childhood: case report and literature review.
  • Gallbladder polypoid lesions are rare in the pediatric patient and sometimes represent an incidental finding.
  • A routine abdominal ultrasound (US) detected a gallbladder polypoid lesion 6 mm in diameter, initially considered a gallbladder adenoma.
  • How does the presence of symptoms worsen the diagnosis and lead to preferring a surgical approach (cholecystectomy) over an echographic follow-up?
  • [MeSH-major] Gallbladder Diseases / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Follow-Up Studies. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / ultrasonography. Humans. Male. Radiography, Abdominal. Remission, Spontaneous. Time Factors

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  • (PMID = 18491679.001).
  • [ISSN] 0391-5387
  • [Journal-full-title] La Pediatria medica e chirurgica : Medical and surgical pediatrics
  • [ISO-abbreviation] Pediatr Med Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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20. Stokes MC, Burnette R, Ballard B, Ross C, Beech DJ: Adenomatous hyperplasia of the gallbladder. J Natl Med Assoc; 2007 Aug;99(8):959-61
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  • [Title] Adenomatous hyperplasia of the gallbladder.
  • Adenomatous hyperplasia of the gallbladder is an uncommon condition, particularly in men.
  • [MeSH-major] Adenoma / surgery. Gallbladder / pathology. Gallbladder Neoplasms / surgery

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  • [Cites] Am J Surg. 2004 Aug;188(2):186-90 [15249249.001]
  • [Cites] Arch Pathol. 1970 Nov;90(5):423-32 [4319984.001]
  • [Cites] Pediatr Surg Int. 2003 Apr;19(1-2):118-9 [12721743.001]
  • [Cites] Eur Radiol. 2005 Apr;15(4):694-701 [15565318.001]
  • [Cites] J Surg Oncol. 2006 Jun 15;93(8):615-23 [16724345.001]
  • [Cites] J Indian Med Assoc. 1992 Jul;90(7):178-81 [1401974.001]
  • (PMID = 17722678.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2574303
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21. Katabi N: Neoplasia of gallbladder and biliary epithelium. Arch Pathol Lab Med; 2010 Nov;134(11):1621-7
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  • [Title] Neoplasia of gallbladder and biliary epithelium.
  • CONTEXT: Diagnosis of biliary neoplasia can be challenging but is essential for the appropriate clinical management of patients.
  • Therefore, it is important to recognize the morphologic features of the biliary neoplasms to report a correct diagnosis. OBJECTIVES:.
  • (1) To discuss the differential diagnosis of dysplasia in the gallbladder and differentiate dysplasia from reactive atypia and invasive carcinoma, (2) review the histologic features of adenoma and polypoid biliary lesions, (3) highlight the differential diagnosis of adenocarcinoma in liver biopsy, and (4) discuss the differential diagnosis of atypical biliary glandular lesions.
  • DATA SOURCES: Current English literature related to gallbladder and biliary neoplasia.
  • Careful examination of the histologic features of these lesions and familiarity with their morphology can help to achieve the correct diagnosis.
  • [MeSH-major] Adenoma / pathology. Bile Duct Neoplasms / pathology. Carcinoma / pathology. Gallbladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Metaplasia / pathology

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  • (PMID = 21043815.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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22. Saldaña DG, de Acosta DA, Alemán HP, Gebrehiwot D, Torres E: Gallbladder endometrioma associated with obstructive jaundice and a serous ovarian cystic adenoma. South Med J; 2010 Dec;103(12):1250-2
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  • [Title] Gallbladder endometrioma associated with obstructive jaundice and a serous ovarian cystic adenoma.
  • The occurrence of pelvic endometriosis is not uncommon, but endometriosis of the gallbladder is extremely rare.
  • This report concerns another patient with gallbladder endometriosis, which formed two distinct lesions at the fundus of the organ.
  • Endometriosis should be considered in the differential diagnosis of a fertile woman with a painful mass, particularly if the mass is associated in size and tenderness with menstrual variability.
  • [MeSH-major] Cystadenoma, Serous / complications. Endometriosis / complications. Gallbladder Diseases / complications. Jaundice, Obstructive / complications. Ovarian Neoplasms / complications
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Gallbladder / pathology. Humans. Ovary / pathology

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  • (PMID = 21037517.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Lee JS, Lee KT, Jung JH, Ok SW, Choi SC, Lee KH, Lee JK, Heo JS, Choi SH, Rhee JC: [Factors associated with malignancy in gallbladder polyps without gallbladder stone]. Korean J Gastroenterol; 2008 Aug;52(2):97-105
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  • [Title] [Factors associated with malignancy in gallbladder polyps without gallbladder stone].
  • BACKGROUND/AIMS: The purpose of this study was to find the factors predicting the neoplastic polyp of gallbladder and analyze the size criteria associated with malignancy.
  • METHODS: A total of 354 subjects with gallbladder polyps confirmed by tissue pathology were included for the analysis.
  • The clinical and radiological features of the polyps were compared between the two groups (neoplastic vs. non-neoplastic) and in the three groups (non-neoplastic vs. adenoma vs. adenocarcinoma).
  • RESULTS: Of 354 patients, non-neoplastic polyps were observed in 229 (64.7%) patents, adenoma in 85 (24.0%) and adenocarcinoma in 40 (11.3%).
  • The mean diameter of non-neoplastic polyp, adenoma, and adenocarcinoma were 11.3+/-2.8 mm, 16.0+/-7.2 mm, and 27.0+/-8.9 mm, respectively.
  • The mean age of patients with non-neoplastic polyp, adenoma, and adenocarcinoma were 44.8+/-11.3, 49.9+/-12.5, and 60.8+/-9.6, respectively.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis. Polyps / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Adult. Aged. Aged, 80 and over. Data Interpretation, Statistical. Female. Humans. Male. Middle Aged. Odds Ratio. Predictive Value of Tests. ROC Curve

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  • (PMID = 19077501.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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24. Ito H, Hann LE, D'Angelica M, Allen P, Fong Y, Dematteo RP, Klimstra DS, Blumgart LH, Jarnagin WR: Polypoid lesions of the gallbladder: diagnosis and followup. J Am Coll Surg; 2009 Apr;208(4):570-5
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  • [Title] Polypoid lesions of the gallbladder: diagnosis and followup.
  • BACKGROUND: Polypoid lesions of the gallbladder (PLG) are commonly seen on ultrasonography (US), but optimal management of this problem is ill-defined.
  • Patients with infiltrative masses suspicious for gallbladder cancer were not included.
  • Neoplastic polyps (adenoma) were found in 10% of patients.
  • [MeSH-major] Gallbladder Diseases / ultrasonography. Polyps / ultrasonography
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adenoma / ultrasonography. Adult. Aged. Aged, 80 and over. Cholecystectomy. Female. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery. Gallbladder Neoplasms / ultrasonography. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 19476792.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Roa I, de Aretxabala X, Araya JC, Roa J: Preneoplastic lesions in gallbladder cancer. J Surg Oncol; 2006 Jun 15;93(8):615-23
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  • [Title] Preneoplastic lesions in gallbladder cancer.
  • BACKGROUND: Gallbladder cancer is an uncommon disease except in countries like Chile and areas of India and Japan.
  • RESULTS: The epithelial lesions involved in gallbladder carcinogenesis are dysplasia and adenomas that represent two biologically distinct carcinogenetic models.
  • Over 80% of invasive gallbladder cancers present areas adjacent to the CIS and epithelial dysplasia.
  • Other authors have demonstrated adenomatous areas in carcinomas, or malignant transformation in an adenoma.
  • The low incidence of gallbladder adenomas (0.14% of cholecystectomies) and the presence of adenomatous remnants in the neighboring mucosa to early carcinomas in less than 3% of the cases suggest the limited importance of this carcinogenic pathway.
  • Epithelial dysplasia which is not associated with gallbladder cancer is observed in approximately 1% of cholecystectomies for symptomatic lithiasis.
  • CONCLUSIONS: From the morphological point of view, the dysplasia-carcinoma sequence is the most plausible carcinogenic pathway for gallbladder cancer, a process which would require a period of approximately 10 years.
  • [MeSH-major] Adenoma / pathology. Carcinoma in Situ / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology. Precancerous Conditions / pathology

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16724345.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 86
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26. Albores-Saavedra J, Keenportz B, Bejarano PA, Alexander AA, Henson DE: Adenomyomatous hyperplasia of the gallbladder with perineural invasion: revisited. Am J Surg Pathol; 2007 Oct;31(10):1598-604
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  • [Title] Adenomyomatous hyperplasia of the gallbladder with perineural invasion: revisited.
  • We report 9 examples of segmental adenomyomatous hyperplasia of the gallbladder with perineural invasion.
  • Eight patients had gallbladder calculi.
  • The original pathologic diagnosis of adenocarcinoma was made in 5 patients and of "adenoma malignum" in one.
  • The second type was characterized by an extensively fibrotic gallbladder wall with numerous RASs but with few or no smooth muscle bundles and an expanded subserosal layer containing abundant nerve-trunks (3 cases).
  • The pseudoinvasive pattern of the RASs, reactive epithelial atypia, and the perineural and intraneural invasion probably contributed to the erroneous diagnosis of adenocarcinoma or "adenoma malignum."
  • [MeSH-major] Adenomyoma / pathology. Gallbladder / innervation. Gallbladder Diseases / pathology. Peripheral Nervous System / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Aged. Aged, 80 and over. Cholelithiasis / pathology. Cholelithiasis / surgery. Diagnosis, Differential. Female. Humans. Hyperplasia. Male. Middle Aged. Muscle, Smooth. Reoperation

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  • (PMID = 17895763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Castillo J, García P, Roa JC: [Genetic alterations in preneoplastic and neoplastic injuries of the gallbladder]. Rev Med Chil; 2010 May;138(5):595-604
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  • [Title] [Genetic alterations in preneoplastic and neoplastic injuries of the gallbladder].
  • [Transliterated title] Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar.
  • This article aims to review the most relevant morphological and molecular aspects involved in gallbladder (GB) cancer.
  • In Chile, gallbladder cancer is the main cause of death due to cancer, among women older than 40 years.
  • The sequence adenoma-carcinoma is accepted to be less frequent and important.
  • Molecular research studies show genetic anomalies in some genes which are temporary events in preneoplastic injuries of the gallbladder.
  • [MeSH-major] Epigenomics. Gallbladder Neoplasms / genetics. Precancerous Conditions / genetics
  • [MeSH-minor] Gallbladder / pathology. Genes, Tumor Suppressor. Humans. Metaplasia. Mutation. Oncogenes / genetics

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  • (PMID = 20668816.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Chile
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28. Arévalo F, Arias Stella C, Monge E: [Immunoexpression of p53 and cyclin D1 in adenomas of the gallbladder]. Rev Esp Enferm Dig; 2007 Dec;99(12):694-7
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  • [Title] [Immunoexpression of p53 and cyclin D1 in adenomas of the gallbladder].
  • [Transliterated title] Inmunoexpresión de p53 y ciclina D1 en adenomas de vesícula biliar.
  • INTRODUCTION: Gallbladder adenomas are infrequent neoplasms whose relation to adenocarcinoma is not well understood.
  • MATERIAL AND METHODS: This is a comparative, cross-sectional study in which we compared p53 and D1 cyclin expression in adenomas and adenocarcinomas of the gallbladder.
  • CONCLUSION: Our results support the hypothesis that p53 is an important step in the pathogenesis of adenocarcinomas but not of adenomas of the gallbladder.
  • [MeSH-major] Adenoma / metabolism. Cyclin D1 / biosynthesis. Gallbladder Neoplasms / metabolism. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 18290692.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1
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29. Akatsu T, Aiura K, Shimazu M, Ueda M, Wakabayashi G, Tanabe M, Kawachi S, Kitajima M: Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps? Dig Dis Sci; 2006 Feb;51(2):416-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can endoscopic ultrasonography differentiate nonneoplastic from neoplastic gallbladder polyps?
  • The present study aimed to clarify the endoscopic ultrasonography (EUS) features of nonneoplastic (cholesterol polyps and adenomyomatosis) and neoplastic (adenoma and adenocarcinoma) gallbladder polyps and to evaluate the effectiveness and limitation of EUS in the differential diagnosis of these lesions.
  • We retrospectively compared EUS images with histologic findings in 29 surgical cases with gallbladder polyps with a diameter of 10 to 20 mm.
  • In conclusion, 69% (20/29) of gallbladder polyps larger than 10 mm that were preoperatively suspected of malignancy were nonneoplastic.
  • [MeSH-major] Adenocarcinoma / ultrasonography. Adenoma / ultrasonography. Endosonography. Gallbladder Diseases / ultrasonography. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16534690.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Krstic M, Alempijevic T, Stimec B, Micev M, Milicevic M, Micic D, Jankovic G: Gallbladder villous adenoma in a patient with acromegaly: a case report. World J Gastroenterol; 2007 Jun 14;13(22):3144-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gallbladder villous adenoma in a patient with acromegaly: a case report.
  • An open cholecystectomy was performed and revealed a villous adenoma with several foci of carcinoma in situ.
  • [MeSH-major] Acromegaly. Adenoma, Villous / ultrasonography. Gallbladder Neoplasms / ultrasonography

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  • (PMID = 17589936.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4172627
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31. Hattori M, Inui K, Yoshino J, Miyoshi H, Okushima K, Nakamura Y, Naito T, Imaeda Y, Horibe Y, Hattori T, Nakazawa S: [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jun;104(6):790-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Usefulness of contrast-enhanced ultrasonography in the differential diagnosis of polypoid gallbladder lesions].
  • We investigated the usefulness of contrast-enhanced ultrasonography for differential diagnosis of polypoid gallbladder lesions in 60 patients, consisting of gallbladder carcinoma in 20, adenoma in 2, benign polyp in 29, and adenomyomatosis in 9, comparing contrast enhancement patterns with pathologic findings.
  • In gallbladder carcinoma, the TIC rose from no contrast to early-phase contrast sooner than in other diseases.
  • Ultrasonographic contrast enhancement patterns show characteristic associations with pathologic findings and serve as valuable adjuncts in the diagnosis of gallbladder diseases.
  • [MeSH-major] Adenoma / ultrasonography. Gallbladder Neoplasms / ultrasonography. Polyps / ultrasonography. Ultrasonography, Doppler / methods
  • [MeSH-minor] Adenomyoma / pathology. Adenomyoma / ultrasonography. Contrast Media / administration & dosage. Diagnosis, Differential. Humans. Neoplasm Staging

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  • (PMID = 17548945.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
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32. Vialle R, Velasco S, Milin S, Bricot V, Richer JP, Levillain PM, Tasu JP: [Imaging in the diagnosis and the staging of gallbladder tumors]. Gastroenterol Clin Biol; 2008 Nov;32(11):931-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Imaging in the diagnosis and the staging of gallbladder tumors].
  • [Transliterated title] Place de l'imagerie dans le diagnostic et le bilan des tumeurs de la vésicule biliaire.
  • Most of gallbladder tumors are benign.
  • Adenoma, cholesterol polyps, or adenomyomatosis are most frequently typical on ultrasonographic images.
  • In case of suspicious polyp or suspicious wall thickening, endoscopic ultrasonography can be helpful to evaluate local tumoral spread and eliminate differential diagnosis.
  • Unfortunately, diagnosis of gallbladder cancer is often late, when surgical resection can't be curative.
  • [MeSH-major] Gallbladder Neoplasms / diagnosis

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  • (PMID = 18954953.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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33. Roa I, de Aretxabala X, Ibacache G, Muñoz S: [Association between cholesterolosis and gallbladder cancer]. Rev Med Chil; 2010 Jul;138(7):804-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Association between cholesterolosis and gallbladder cancer].
  • [Transliterated title] Colesterolosis y cáncer de la vesícula biliar.
  • AIM: To determine the degree of association between cholesterolosis and gallbladder cancer.
  • MATERIAL AND METHODS: In a prospective study of gallbladder cancer, all gallbladders obtained during cholecystectomies were processed for pathological study, following a special protocol.
  • As part of this study, 23,304 surgical samples obtained between 1993 and 2002 were studied, looking for a relationship between cholesterolosis and chronic cholecystitis, adenomas, dysplasia and gallbladder cancer.
  • In the same period, 29 patients were diagnosed with adenomas (0.12%), 179 cases with dysplasia not associated with gallbladder cancer (0.8%) and 739 gallbladder cancer (3.2%).
  • The frequency of cholesterolosis was 13.8% in chronic cholecystitis, 13.7% in adenomas, 12.1% in dysplasias and 1.35% in patients with gallbladder cancer (p < 0.01).
  • Of the thirteen cases with gallbladder cancer and cholesterolosis, 10 were early gallbladder carcinomas.
  • CONCLUSIONS: Cholesterolosis has a strong negative association with gallbladder cancer.
  • [MeSH-major] Adenoma / epidemiology. Cholelithiasis / epidemiology. Gallbladder Neoplasms / epidemiology

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  • (PMID = 21043073.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Chile
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34. Kim J, Jang KT, Kim KH, Park JW, Chang BJ, Lee KH, Lee JK, Heo JS, Choi SH, Choi DW, Rhee JC, Lee KT: Aberrant maspin expression is involved in early carcinogenesis of gallbladder cancer. Tumour Biol; 2010 Oct;31(5):471-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrant maspin expression is involved in early carcinogenesis of gallbladder cancer.
  • Recently, we identified several genes that may be tumor markers for gallbladder (GB) cancer using a DNA microarray method.
  • The aims of this study were to determine maspin expression in normal mucosa, adenoma, dysplasia and carcinoma of GB, and to compare the pattern of maspin expression in early and advanced GB cancers.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / metabolism. Cell Transformation, Neoplastic / metabolism. Gallbladder Neoplasms / metabolism. Serpins / biosynthesis
  • [MeSH-minor] Adenoma / metabolism. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Tissue Array Analysis

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  • (PMID = 20517662.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / SERPIN-B5; 0 / Serpins
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35. Vieth M, Kushima R, de Jonge JP, Borchard F, Oellig F, Stolte M: Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum. Virchows Arch; 2005 May;446(5):542-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum.
  • In a 46-year-old man, a pedunculated rectal polyp measuring 3.0x3.0x2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa.
  • Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb.
  • The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.
  • [MeSH-major] Adenoma / pathology. Choristoma. Gastric Mucosa. Intestinal Polyps / pathology. Rectal Neoplasms / pathology

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  • (PMID = 15838648.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6; 0 / Mucins
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36. Zins M, Boulay-Coletta I, Molinié V, Mercier-Pageyral B, Jullès MC, Rodallec M, Petit E, Berrod JL: [Imaging of a thickened-wall gallbladder]. J Radiol; 2006 Apr;87(4 Pt 2):479-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Imaging of a thickened-wall gallbladder].
  • [Transliterated title] Imagerie des épaississements de la paroi vésiculaire.
  • Thickening of the gallbladder wall may result from a large spectrum of pathological conditions, intrinsic as well as extrinsic to the biliary tract, and may have different appearances.
  • Accurate diagnosis is usually established after a correlation of imaging findings, laboratory data and clinical history.
  • CT and MRI are complementary to US and have an increasing role in assessing a thickened-wall gallbladder.
  • [MeSH-major] Gallbladder Diseases / diagnosis
  • [MeSH-minor] Acalculous Cholecystitis / diagnosis. Acalculous Cholecystitis / radiography. Acalculous Cholecystitis / ultrasonography. Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Adenocarcinoma / ultrasonography. Adenoma / diagnosis. Adenoma / radiography. Adenoma / ultrasonography. Adenomyoma / diagnosis. Adenomyoma / radiography. Adenomyoma / ultrasonography. Cholecystitis, Acute / diagnosis. Cholecystitis, Acute / radiography. Cholecystitis, Acute / ultrasonography. Cholecystolithiasis / ultrasonography. Diagnosis, Differential. Female. Gallbladder / pathology. Gallbladder / ultrasonography. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / radiography. Gallbladder Neoplasms / ultrasonography. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16691177.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 48
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37. Tanaka S, Tanaka H, Yamamoto T, Shuto T, Takemura S, Hai S, Sakabe K, Uenishi T, Hirohashi K, Kubo S: Immunohistochemical demonstration of c-Kit protooncogene product in gallbladder cancer. J Hepatobiliary Pancreat Surg; 2006;13(3):228-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical demonstration of c-Kit protooncogene product in gallbladder cancer.
  • BACKGROUND/PURPOSE: Although some gallbladder carcinomas are immunoreactive for c-Kit, the reasons for the c-Kit expression and its clinicopathologic implications are unknown.
  • We reviewed retrospectively, the clinicopathologic records of 47 patients who had undergone macroscopically complete gallbladder carcinoma resection.
  • Control tissue samples were from five gallbladder specimens each with chronic cholecystitis, polyp, and adenoma.
  • RESULTS: Cytoplasmic immunostaining for c-Kit was detected in 21 of the 47 gallbladder carcinomas (45%), and in 1 of the 15 control specimens (diagnosis, chronic cholecystitis).
  • However, microvessel density was significantly higher in c-Kit-positive gallbladder carcinoma compared with c-Kit-negative gallbladder carcinoma.
  • CONCLUSIONS: Gallbladder carcinomas positive for c-Kit are unlikely to arise from immature cells, but may be associated with neovascularization.
  • Angiogenesis inhibitors, such as tyrosine kinase inhibitors, therefore, may suppress the growth of some gallbladder cancers.
  • [MeSH-major] Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Proto-Oncogene Proteins c-kit / metabolism

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  • (PMID = 16708300.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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38. Wiedmann M, Schoppmeyer K, Witzigmann H, Hauss J, Mössner J, Caca K: [Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder]. Z Gastroenterol; 2005 Mar;43(3):305-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder].
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumour, middle and distal extrahepatic tumours), gallbladder cancer, and ampullary carcinoma.
  • Transformation of normal into malignant bile duct tissue requires a chain of consecutive gene mutations, similar to the adenoma-dysplasia-carcinoma-sequence in colon cancer.
  • Abdominal ultrasound, combined non-invasive magnetic resonance cholangiography/tomography (MRC/MRT), and facultatively endoscopic retrograde cholangiography (ERC) for unclear diagnosis, represent the gold standard for primary diagnosis.
  • [MeSH-major] Bile Duct Neoplasms. Gallbladder Neoplasms
  • [MeSH-minor] Algorithms. Ampulla of Vater. Bile Ducts / pathology. Bile Ducts, Intrahepatic. Biopsy. Brachytherapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / therapy. Cyclooxygenase Inhibitors / therapeutic use. Gallbladder / pathology. Hepatectomy. Hepatic Duct, Common. Humans. Klatskin Tumor / diagnosis. Klatskin Tumor / therapy. Magnetic Resonance Imaging. Neoplasm Staging. Palliative Care. Retrospective Studies. Risk Factors. Stents. Time Factors

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  • [CommentIn] Z Gastroenterol. 2005 May;43(5):473-5 [15871071.001]
  • (PMID = 15765304.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors
  • [Number-of-references] 153
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39. Hughes NR, Goodman ZD, Bhathal PS: An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis. Am J Surg Pathol; 2010 Sep;34(9):1312-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis.
  • The so-called bile duct adenoma and peribiliary glands are characterized by the expression of two foregut antigens (designated D10 and 1F6) and secretion of acid mucin.
  • On account of this similarity in phenotype and their frequent close association with a large caliber bile duct, it was earlier suggested that bile duct adenoma represent a peribiliary gland hamartoma.
  • Here, we compare the expression of 13 tissue antigens in bile duct adenomas, other benign bile duct lesions, and various foregut-derived tissues, to further investigate the bile duct adenoma phenotype and pathogenesis.
  • Five foregut antigens (D10, 1F6, MUC6, MUC5AC, and TFF2) and secretion of acid mucin were of use in distinguishing bile duct adenoma from other hepatic lesions.
  • Thirty-six bile duct adenomas examined were distinguished by expression of MUC6 (94% of bile duct adenoma), MUC5AC (90%), TFF2 (80%), D10 (67%), and 1F6 (61%), and varying degrees of acid mucin secretion (100%).
  • Of 30 bile duct adenoma tested for all 5 antigens, 40% expressed all 5, 27% expressed 4, 17% expressed 3, 13% expressed 2, and 1 expressed only MUC6.
  • The acini of pyloric gland metaplasia in gallbladder and terminal ileum also stained for D10, 1F6, MUC6, and TFF2, with MUC5AC focally present in the gastric foveolar metaplasia overlying the pyloric gland metaplasia but not in the metaplastic glands.
  • The distinguishing feature of so-called bile duct adenoma is their display of the same phenotype as pyloric gland metaplasia.
  • [MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology

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  • (PMID = 20679879.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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40. Zülke C, Schlitt HJ: [Incidentalomas of the liver and gallbladder. Evaluation and therapeutic procedure]. Chirurg; 2007 Aug;78(8):698-712
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  • [Title] [Incidentalomas of the liver and gallbladder. Evaluation and therapeutic procedure].
  • The correct diagnosis of hepatic incidentaloma may be made in over 90% with non-invasive means.
  • The questionable diagnosis of "symptomatic" incidentaloma should undergo close scrutiny prior to a decision in favour of surgery.
  • With regard to more recent literature, the former "absolute" requirement for surgical resection in all cases of liver cell adenoma may have to be reappraised.
  • Percutaneous biopsies should not be performed due to oncological hazards, indeterminate results and potential for acute complications.The stage-oriented radical re-resection following diagnosis of an incidentally detected gallbladder cancer may lead to significantly improved long-term survival, especially in the early tumour stages T1b and T2, which represents the most common stage of gallbladder cancer in incidentaloma.
  • Patients at elevated risk for incidental gallbladder cancer should undergo thorough instruction with regard to the potential hazards of laparoscopic cholecystectomy.
  • Multimodal therapeutic strategies directed at advanced stages of incidentally detected gallbladder cancer should be evaluated in prospective multicentre studies.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Gallbladder Diseases / diagnosis. Gallbladder Neoplasms / diagnosis. Incidental Findings. Liver Diseases / diagnosis. Liver Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Biopsy. Cholecystectomy. Diagnosis, Differential. Diagnostic Imaging. Gallbladder / pathology. Hepatectomy. Humans. Lymph Node Excision. Lymphatic Metastasis. Neoplasm Staging. Patient Care Team. Prognosis

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  • (PMID = 17661000.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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41. Spaziani E, Petrozza V, Di Filippo A, Picchio M, Ceci F, Miraglia A, Moretti V, Briganti M, Greco E, Pattaro G, De Angelis F, Salvadori C, Stagnitti F: [Gallbladder polypoid lesions. Three clinical cases with difficult diagnosis and literature review]. G Chir; 2010 Oct;31(10):439-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gallbladder polypoid lesions. Three clinical cases with difficult diagnosis and literature review].
  • [Transliterated title] Lesioni polipoidi della colecisti. Presentazione di tre casi clinici di "difficile" diagnosi e revisione della letteratura.
  • INTRODUCTION: Gallbladder polypoid lesions occur in 1.3%-6.9% of cases.
  • The preoperative diagnosis between benign, malignant and potentially malignant lesions is difficult.
  • The case 1 was a gallbladder diffuse adenomyomatosis; the ultrasound and the CT were of little help in defining preoperatively the nature and the gravity of the thickening.
  • DISCUSSION: The ultrasound is the most widely used diagnostic tool in the evaluation of gallbladder polypoid lesions; its accuracy is only 66%.
  • CONCLUSIONS: The preoperative diagnosis of the nature of gallbladder polypoid lesions is "difficult" and this justifies the lack of consensus on treatment.
  • However, the adenoma-carcinoma sequence, widely discussed in literature, can justifies to the use of CT, MR, PET and surgical treatment after an ultrasound examination.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Polyps / diagnosis

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  • (PMID = 20939951.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
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42. Sanada T, Baba H, Ohba A, Wakabayashi M, Ebana H, Nakamura H, Kuwabara H, Tamai S, Nakajima K, Maruyama S, Goseki N: [Gallbladder carcinoma, progressed along cholecystoduodenal fistula--a case report]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2717-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Gallbladder carcinoma, progressed along cholecystoduodenal fistula--a case report].
  • A 75-year-old woman had an operation for gallstone ileus without cholecystectomy in other hospital and she was admitted to our hospital because of duodenal adenoma with severe atypia and small carcinoid in proximal duodenal wall.
  • Histological studies revealed the existence of cholecystoduodenal fistula and suggested the existence of gallbladder carcinoma progressed to the duodenal wall through the fistula.
  • It has been theorized that a cholecystoduodenal fistula may represent a significant risk factor in the development of gallbladder carcinoma because of the chronic reflux of duodenal contents which includes pancreatic juice.
  • In this case, we thought that the formation of gallbladder cancer could have been avoided if the cholecystectomy was performed in the first operation for gallstone ileus.
  • [MeSH-major] Duodenal Diseases / complications. Duodenum / pathology. Gallbladder Diseases / complications. Gallbladder Neoplasms / pathology. Intestinal Fistula / complications

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  • (PMID = 21224690.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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43. Numata K, Oka H, Morimoto M, Sugimori K, Kunisaki R, Nihonmatsu H, Matsuo K, Nagano Y, Nozawa A, Tanaka K: Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography. J Ultrasound Med; 2007 Jun;26(6):763-74
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  • [Title] Differential diagnosis of gallbladder diseases with contrast-enhanced harmonic gray scale ultrasonography.
  • OBJECTIVES: We evaluated the usefulness of contrast-enhanced harmonic gray scale ultrasonographic findings for differential diagnosis of gallbladder diseases.
  • METHODS: We evaluated contrast-enhanced harmonic gray scale ultrasonographic images from 33 patients with 35 polypoid gallbladder disease lesions larger than 10 mm in diameter, consisting of 12 biliary sludge lesions, 8 cholesterol polyps, 1 inflammatory polyp, 2 adenomas, and 12 carcinomas.
  • Lesions showing tumor vessels and tumor enhancement on contrast-enhanced harmonic gray scale ultrasonography were diagnosed as cholesterol polyp, inflammatory polyp, adenoma, or carcinoma.
  • Lesions with tumor enhancement and tortuous-type tumor vessels on contrast-enhanced harmonic gray scale ultrasonography were diagnosed as carcinomas, and the sensitivity, specificity, and accuracy of this diagnosis with the current modality were 75% (9/12), 100% (23/23), and 91% (32/35), respectively.
  • CONCLUSIONS: Evaluation of tumor vessels on contrast-enhanced harmonic gray scale ultrasonography may be a useful modality for differentiating gallbladder carcinoma from other polypoid gallbladder disease lesions.
  • [MeSH-major] Gallbladder Diseases / ultrasonography. Image Enhancement / methods. Polysaccharides. Ultrasonography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 17526608.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Polysaccharides; 127279-08-7 / SHU 508
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44. Kim HS, Kim GY, Lim SJ, Park YK, Kim YW: Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma. Hum Pathol; 2010 Nov;41(11):1609-16
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  • [Title] Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma.
  • Gallbladder carcinoma is one of the most aggressive malignancies.
  • Because of the lack of reliable prognostic markers, the aim of this study was to investigate the prognostic significance of Raf-1 kinase inhibitory protein expression in gallbladder carcinomas.
  • Immunostaining for Raf-1 kinase inhibitory protein was performed on chronic cholecystitis, adenoma, carcinoma in situ, and primary and nodal metastatic gallbladder carcinoma.
  • Raf-1 kinase inhibitory protein expression was reduced in 68.8% (11/16) and 42.3% (44/104) of nodal metastatic and primary gallbladder carcinoma cases, respectively, but in no case of carcinoma in situ, adenoma, or chronic cholecystitis.
  • The differences in Raf-1 kinase inhibitory protein expression in gallbladder carcinoma versus nongallbladder carcinoma tissues (P < .001), and in nodal metastatic gallbladder carcinoma versus primary gallbladder carcinoma (P = .009), were statistically significant.
  • Kaplan-Meier curves showed that patients with Raf-1 kinase inhibitory protein-negative or weakly positive gallbladder carcinoma had a significantly shorter overall survival than did patients with Raf-1 kinase inhibitory protein-positive gallbladder carcinoma (median, 14 versus 120 months; P = .011).
  • Our results suggest that reduction in Raf-1 kinase inhibitory protein expression in gallbladder carcinoma contributes to invasion and metastasis and is a significant prognostic marker in patients with gallbladder carcinoma.
  • [MeSH-major] Adenocarcinoma / enzymology. Biomarkers / metabolism. Gallbladder Neoplasms / enzymology. Proto-Oncogene Proteins c-raf / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Cholecystectomy. Cholecystitis / metabolism. Cholecystitis / pathology. Chronic Disease. Female. Humans. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20688353.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; EC 2.7.11.1 / Proto-Oncogene Proteins c-raf
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45. Goldin RD, Roa JC: Gallbladder cancer: a morphological and molecular update. Histopathology; 2009 Aug;55(2):218-29
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  • [Title] Gallbladder cancer: a morphological and molecular update.
  • Gallbladder cancer (GBC) shows a marked geographical variation in its incidence, with the highest figures being seen in India and Chile and relatively low levels in many Western countries.
  • It can arise from either a pathway involving metaplasia or dysplasia or one in which there is a pre-existing adenoma.
  • [MeSH-major] Gallbladder Neoplasms / genetics. Gallbladder Neoplasms / pathology

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  • (PMID = 19490172.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; EC 2.7.11.1 / p21-Activated Kinases
  • [Number-of-references] 139
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46. Chaube A, Tewari M, Garbyal RS, Singh U, Shukla HS: Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. BMC Cancer; 2006;6:126
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  • [Title] Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582.
  • In the present study, our aim was to determine the role of these genes in the carcinogenesis of gallbladder by immunohistochemistry.
  • CONCLUSION: Only one case of gall bladder cancer co-expressed the p53 and c-erbB-2, thereby suggesting that p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer. c-erbB-2 over expression in adenoma and younger age group indicates its role as an early event in carcinogenesis of gallbladder.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Gallbladder Neoplasms / metabolism. Gene Expression Regulation, Neoplastic. Receptor, ErbB-2 / metabolism. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 16686942.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ PMC1472691
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47. Moon WS, Park HS, Lee H, Pai R, Tarnawski AS, Kim KR, Jang KY: Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer. Cancer Res Treat; 2005 Jun;37(3):171-6
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  • [Title] Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer.
  • PURPOSE: Gallbladder cancer is a malignancy with poor prognosis, predominantly resulting from invasion and metastasis.
  • To determine whether these findings are applicable to clinical conditions, we examined the expression and cellular localization/co-localization of Cox-2, c-Met, beta-catenin, EGFR and c-erbB2 in gallbladder cancer.
  • MATERIALS AND METHODS: Thirty-five specimens of invasive gallbladder cancer, 8 in situ carcinoma and 7 adenoma specimens were immunostained with specific antibodies against Cox-2, c-Met, beta-catenin, EGFR and c-erbB2.
  • The cellular distribution, localization and colocalization were examined, and the signal intensities quantified in: a) the central area of gallbladder cancer and b) cancer cells forming the invasive front.
  • RESULTS: Cox-2, c-Met, beta-catenin, c-erbB2 and EGFR were over-expressed in 80, 74, 71, 62 and 11% of invasive gallbladder cancers, respectively. beta-catenin was expressed in 80% of non-malignant specimens, exclusively in the cell membrane, while the cancer specimens showed cytoplasmic and/or nuclear staining.


48. Hirata K, Ajiki T, Okazaki T, Horiuchi H, Fujita T, Kuroda Y: Frequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis. Oncology; 2006;71(1-2):102-10
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  • [Title] Frequent occurrence of abnormal E-cadherin/beta-catenin protein expression in advanced gallbladder cancers and its association with decreased apoptosis.
  • OBJECTIVE: Our aim is to assess the clinicopathological significance of E-cadherin and beta-catenin expression, as well as their association with apoptosis in gallbladder cancers.
  • METHODS: The expression of E-cadherin and beta-catenin proteins was examined in 4 biliary tract cancer cell lines and 49 gallbladder cancer specimens by immunofluorescent or immunohistochemical methods and Western blotting.
  • Reduced expression of E-cadherin and beta-catenin was frequently seen in advanced gallbladder cancer cases (61 and 83%, respectively) relative to pT1 cases (25 and 63%, respectively).
  • CONCLUSIONS: The expression of E-cadherin or beta-catenin frequently diminishes as the tumor progresses, and abnormalities of E-cadherin and beta-catenin expression were associated with decreased apoptosis in gallbladder cancers.
  • [MeSH-major] Apoptosis. Biomarkers, Tumor / metabolism. Cadherins / metabolism. Gallbladder Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Aged. Biliary Tract Neoplasms / metabolism. Biliary Tract Neoplasms / pathology. Epithelium / metabolism. Epithelium / pathology. Female. Fluorescent Antibody Technique. Humans. Immunoenzyme Techniques. Lymphatic Metastasis / pathology. Male. Neoplasm Staging. Poly(ADP-ribose) Polymerases / metabolism. Prognosis. Survival Rate

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  • (PMID = 17341890.001).
  • [ISSN] 0030-2414
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDH1 protein, human; 0 / CTNNB1 protein, human; 0 / Cadherins; 0 / beta Catenin; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases
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49. Park KW, Kim SH, Choi SH, Lee WJ: Differentiation of nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger with multi-detector row computed tomography. J Comput Assist Tomogr; 2010 Jan;34(1):135-9
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  • [Title] Differentiation of nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger with multi-detector row computed tomography.
  • OBJECTIVE: To evaluate useful computed tomographic features to differentiate nonneoplastic and neoplastic gallbladder polyps 1 cm or bigger.
  • Gallbladder polyps were diagnosed by cholecystectomy.
  • CONCLUSIONS: Size bigger than 1.5 cm, sessile shape, and perception on unenhanced images are the main factors that differentiate neoplastic from nonneoplastic gallbladder polyps 1 cm or bigger.
  • [MeSH-major] Adenocarcinoma / radiography. Adenoma / radiography. Gallbladder Neoplasms / radiography. Polyps / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Age Distribution. Cholecystography / methods. Contrast Media. Diagnosis, Differential. Female. Gallbladder Diseases / radiography. Humans. Image Processing, Computer-Assisted / methods. Iopamidol. Male. Middle Aged. Observer Variation. Radiographic Image Enhancement / methods. Retrospective Studies

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  • (PMID = 20118736.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; JR13W81H44 / Iopamidol
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50. Lee YM, Lee JY, Kim MJ, Bae HI, Park JY, Kim SG, Kim DS: Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features. Cancer Sci; 2006 Nov;97(11):1205-10
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  • [Title] Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
  • Gallbladder (GB) cancer is the most common malignant tumor of the biliary tract and is usually associated with gallstone disease, a late diagnosis, unsatisfactory treatment and a poor prognosis.
  • [MeSH-major] DNA Methylation. Gallbladder Neoplasms / genetics. Promoter Regions, Genetic / genetics. Ubiquitin Thiolesterase / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenoma / genetics. Adenoma / pathology. Azacitidine / pharmacology. CpG Islands. DNA, Neoplasm / genetics. DNA, Neoplasm / metabolism. Humans. Immunoenzyme Techniques. Microdissection. Neoplasm Invasiveness. Neoplasm Staging. Polymerase Chain Reaction. Tissue Array Analysis. Tumor Cells, Cultured

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  • (PMID = 16965602.001).
  • [ISSN] 1347-9032
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase; M801H13NRU / Azacitidine
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51. Li Q, Yang Z: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. J Exp Clin Cancer Res; 2009;28:65
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  • [Title] Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations.
  • However, few studies have examined gallbladder cancer specimens, and little is known about the clinical and pathological significance of ERK1/2 and PI3-K/AKT signaling changes in gallbladder adenocarcinoma.
  • In this study, we examined phospho-ERK1/2 (p-ERK1/2) and PI3K expression and analyzed its clinicopathological impact in gallbladder adenocarcinoma.
  • METHODS: Immunohistochemistry was used to detect and compare the frequency of p-ERK1/2 and PI3-K expression in gallbladder adenocarcinoma, peri-tumor tissues, adenomatous polyps, and chronic cholecystitis specimens.
  • RESULTS: The positive staining for p-EKR1/2 and PI3-K were 63/108 (58.3%) and 55/108 (50.9%) in gallbladder adenocarcinoma; 14/46 (30.4%) and 5/46 (10.1%) in peri-tumor tissues; 3/15 (20%) and 3/15 (20%) in adenomatous polyps; and 4/35 (11.4%) and 3/35 (8.6%) in chronic cholecystitis.
  • The positive rate of p-ERK1/2 or PI3-K in gallbladder adenocarcinoma was significantly higher than that in peri-tumor tissue (both, P < 0.01), adenomatous polyps (p-ERK1/2, P < 0.01; PI3-K, P < 0.05), and chronic cholecystitis (both, P < 0.01).
  • Moreover, the frequency of p-ERK1/2 expression in gallbladder adenocarcinomas without gallstone was significantly lower than those with gallstones.
  • Multivariate Cox regression analysis showed that increased p-ERK1/2 expression was an independent prognostic predictor in gallbladder carcinoma (P = 0.028).
  • CONCLUSION: Increased expression of p-ERK1/2 and PI3K might contribute to gallbladder carcinogenesis. p-ERK1/2 over-expression is correlated with decreased survival and therefore may serve as an important biological marker in development of gallbladder adenocarcinoma.
  • [MeSH-major] Gallbladder Neoplasms / metabolism. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / metabolism. Phosphatidylinositol 3-Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / metabolism. Adenoma / pathology. Adenomatous Polyps / metabolism. Adenomatous Polyps / pathology. Adult. Female. Gallbladder / metabolism. Gallbladder / pathology. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Staging. Phosphorylation. Prognosis. Survival Rate

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  • (PMID = 19445727.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
  • [Other-IDs] NLM/ PMC2691734
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52. Tagaya N, Kasama K, Suzuki N, Taketsuka S, Horie K, Kubota K: Simultaneous laparoscopic treatment for diseases of the gallbladder, stomach, and colon. Surg Laparosc Endosc Percutan Tech; 2005 Jun;15(3):169-71
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  • [Title] Simultaneous laparoscopic treatment for diseases of the gallbladder, stomach, and colon.
  • The histopathologic diagnoses were chronic cholecystitis, leiomyoma of the stomach, and tubulovillous adenoma with severe dysplasia of the colon.
  • [MeSH-major] Adenoma, Villous / surgery. Cholecystolithiasis / epidemiology. Cholecystolithiasis / surgery. Colonic Neoplasms / surgery. Laparoscopy. Leiomyoma / surgery. Stomach Neoplasms / surgery

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  • (PMID = 15956904.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Oh SJ, Lee SJ, Lee HY, Paik YH, Lee DK, Lee KS, Chung JB, Yu JS, Yoon DS: [Extrapancreatic tumors in intraductal papillary mucinous neoplasm of the pancreas]. Korean J Gastroenterol; 2009 Sep;54(3):162-6
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  • Five, six, and two extrapancreatic malignancies had been diagnosed before, during, and after the diagnosis of IPMN.
  • Other extrapancreatic tumors included lung cancer (n=2), prostatic cancer (n=1), renal cell carcinoma (n=1), cholangiocellular carcinoma (n=1), urinary bladder cancer (n=1), and gallbladder cancer (n=1), respectively.
  • As benign tumor, there were two gallbladder adenoma, one gastric adenoma, one colonic adenoma and one benign ovarian cystic neoplasm, respectively.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Neoplasms, Multiple Primary / epidemiology. Neoplasms, Second Primary / epidemiology. Pancreatic Neoplasms / diagnosis

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  • [CommentIn] Korean J Gastroenterol. 2009 Sep;54(3):196-8 [19844158.001]
  • (PMID = 19844152.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
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54. Lim SC, Oh SH: The role of CD24 in various human epithelial neoplasias. Pathol Res Pract; 2005;201(7):479-86
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  • The authors aimed at evaluating CD24 protein expression in adenoma and adenocarcinoma of the stomach, colon, gallbladder, ovary, and breast to establish a correlation with clinicopathologic data.
  • The present study clearly demonstrates that CD24 is abundantly expressed in adenocarcinoma compared to adenoma of the colon and breast.
  • Intracytoplasmic CD24 expression was found to be highly associated with adenocarcinoma of the colon, gallbladder, and ovary compared to the adenoma group of those organs, and with the positive nodal status compared to the negative nodal status of the colonic adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Antigens, CD / biosynthesis. Biomarkers, Tumor / analysis. Membrane Glycoproteins / biosynthesis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD24. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Colonic Neoplasms / metabolism. Colonic Neoplasms / pathology. Female. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis / pathology. Male. Middle Aged. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology

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  • (PMID = 16164042.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD24; 0 / Biomarkers, Tumor; 0 / CD24 protein, human; 0 / Membrane Glycoproteins
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55. Izzo L, Costi U, Adduci M, Gazzanelli S, Casullo A, Kharrub Z, Sassayanis PG, Marini M, Stasolla A, Pulcinelli V, Meucci M, Caputo M: [The colecistectomy in primary sclerosing cholangitis: case report and review of literature]. G Chir; 2005 Jan-Feb;26(1-2):37-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Indicazione alla colecistectomia nella colangite sclerosante primitiva: presentazione di un caso clinico e revisione della letteratura.
  • Consideration should be given to performing a cholecystectomy in PSC patients with gallbladder adenomyomas or calculi, even asymptomatic; this happens in approximately 15% of cases.
  • [MeSH-minor] Adenoma / complications. Adenoma / pathology. Bile Ducts / pathology. Cholecystitis / complications. Cholecystolithiasis / complications. Cholecystolithiasis / pathology. Chronic Disease. Follow-Up Studies. Gallbladder / pathology. Gallbladder Neoplasms / complications. Gallbladder Neoplasms / pathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Time Factors

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  • (PMID = 15847093.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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56. Collins AM, Winter DC, McCormick AP, Cottell DC, Geoghegan JG: Amiodarone hepatotoxicity complicating obstructive jaundice due to ampullary cancer. Hepatobiliary Pancreat Dis Int; 2007 Aug;6(4):435-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Painless jaundice associated with a palpable gallbladder was investigated clinically, radiologically, endoscopically and via liver biopsy.
  • Endoscopic biopsy identified an ampullary adenoma.
  • [MeSH-major] Adenoma / complications. Amiodarone / toxicity. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology. Liver / drug effects
  • [MeSH-minor] Aged. Biopsy. Gallbladder / pathology. Humans. Liver Diseases / complications. Male

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  • (PMID = 17690045.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] N3RQ532IUT / Amiodarone
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57. Nuernberg D, Ignee A, Dietrich CF: [Ultrasound in gastroenterology. Biliopancreatic system]. Med Klin (Munich); 2007 Feb 15;102(2):112-26
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  • GALLBLADDER: Ultrasound has become widely accepted for the diagnosis of gallbladder disease.
  • Gallbladder polyps are well detectable.
  • Gallbladder carcinomas as a disease of the older age with few early symptoms are usually detected at a late stage when the liver is already infiltrated.
  • Ductal adenocarcinoma seems to be less vascularized in comparison to the surrounding tissue, while endocrine tumors and macro- and microcystic adenoma are rather hypervascularized.
  • [MeSH-minor] Adenoma / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic / ultrasonography. Carcinoma / ultrasonography. Cholangiocarcinoma / ultrasonography. Cholangitis, Sclerosing / ultrasonography. Cholecystitis / ultrasonography. Choledocholithiasis / ultrasonography. Contrast Media. Diagnosis, Differential. Endosonography. Gallbladder Neoplasms / ultrasonography. Humans. Middle Aged. Pancreatic Neoplasms / ultrasonography. Pancreatitis / ultrasonography. Polyps / ultrasonography. Sensitivity and Specificity. Ultrasonography, Doppler, Color / methods

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  • (PMID = 17323018.001).
  • [ISSN] 0723-5003
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 228
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58. Xu HX: Contrast-enhanced ultrasound in the biliary system: Potential uses and indications. World J Radiol; 2009 Dec 31;1(1):37-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, it is lack of the ability to depict the microcirculation of some lesions which may lead to failure in diagnosis for some biliary diseases.
  • (2) For differentiation diagnosis between ICC and other tumors (i.e. hepatocellular carcinoma or liver metastasis) or infectious diseases;.
  • (3) For differentiation diagnosis between biliary cystadenoma and biliary cystadenocarcinoma;.
  • (6) To make a distinction between gallbladder cholesterol polyp, adenoma and polypoid cancer;.
  • (7) To make a distinction between chronic cholecystitis with thickened wall and gallbladder cancer;.
  • (8) For differentiation diagnosis between motionless sludge and gallbladder cancer;.
  • (9) For differentiation diagnosis between common bile duct cancer and sludge or stone without acoustic shadowing; and (10) In patients who are suspected of having a drop of their percutaneous transhepatic cholangiodrainage tube, US contrast agent can be administered to through the tube detect the site of the tube.

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  • (PMID = 21160719.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999303
  • [Keywords] NOTNLM ; Bile duct / Cholangiocarcinoma / Contrast-enhanced ultrasound / Gallbladder / Polypoid lesion / Ultrasound contrast agent
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59. Zhang YW, Staal B, Su Y, Swiatek P, Zhao P, Cao B, Resau J, Sigler R, Bronson R, Vande Woude GF: Evidence that MIG-6 is a tumor-suppressor gene. Oncogene; 2007 Jan 11;26(2):269-76
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • Moreover, germline disruption of Mig-6 in mice leads to the development of animals with epithelial hyperplasia, adenoma, and adenocarcinoma in organs like the lung, gallbladder, and bile duct.
  • [MeSH-minor] Adenocarcinoma / etiology. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenoma / etiology. Adenoma / metabolism. Adenoma / pathology. Animals. Bile Duct Neoplasms / etiology. Bile Duct Neoplasms / metabolism. Bile Duct Neoplasms / pathology. Blotting, Northern. Blotting, Western. Carcinoma, Non-Small-Cell Lung / metabolism. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Epithelial Cells / pathology. Gallbladder Diseases / etiology. Gallbladder Diseases / metabolism. Gallbladder Diseases / pathology. Gene Expression Regulation, Neoplastic. Hepatocyte Growth Factor / pharmacology. Humans. Hyperplasia / etiology. Hyperplasia / metabolism. Hyperplasia / pathology. Immunoenzyme Techniques. Mice. Mice, Knockout. Mitogen-Activated Protein Kinases / metabolism. Receptor, Epidermal Growth Factor. Signal Transduction. Tumor Cells, Cultured. Tumor Suppressor Proteins


60. Riener MO, Fritzsche FR, Soll C, Pestalozzi BC, Probst-Hensch N, Clavien PA, Jochum W, Soltermann A, Moch H, Kristiansen G: Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas. Histopathology; 2010 Apr;56(5):600-6
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS AND RESULTS: Immunohistochemical periostin expression was semiquantitatively analysed in normal liver tissue (n = 20), hepatocellular carcinoma (HCC; n = 91), liver-cell adenoma (n = 9), focal nodular hyperplasia (n = 13) and bile duct carcinomas (BDC; n = 116) using tissue microarrays.
  • Normal bile ducts, gallbladder epithelium and hepatocytes showed weak cytoplasmic periostin expression.
  • [MeSH-major] Adenoma / metabolism. Bile Duct Neoplasms / metabolism. Carcinoma, Hepatocellular / metabolism. Cell Adhesion Molecules / metabolism. Focal Nodular Hyperplasia / metabolism. Liver Neoplasms / metabolism

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  • (PMID = 20459570.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / POSTN protein, human
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61. Costamagna G, Familiari P, Iacopini F, Shah S, Marchese M: [State of the art in therapeutic biliary endoscopy]. Rev Gastroenterol Mex; 2005 Jul;70 Suppl 1:63-82

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  • [Transliterated title] Ultimos adelantos en endoscopia biliar terapéutica.
  • What should one do with the gallbladder after extraction of common bile duct stone?
  • [MeSH-minor] Adenoma / surgery. Adenoma / therapy. Ampulla of Vater. Animals. Bile Duct Diseases / therapy. Biliary Fistula / therapy. Cholestasis / diagnosis. Cholestasis / therapy. Clinical Trials as Topic. Common Bile Duct Neoplasms / surgery. Common Bile Duct Neoplasms / therapy. Disease Models, Animal. Dogs. Drainage. Follow-Up Studies. Gallstones / therapy. Humans. Lithotripsy. Liver Transplantation. Magnetic Resonance Imaging. Meta-Analysis as Topic. Prosthesis Implantation. Retrospective Studies. Sphincterotomy, Endoscopic. Time Factors

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  • (PMID = 17469411.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 218
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62. Sohn VY, Arthurs ZM, Martin MJ, Sebesta JA, Branch JB, Champeaux AL: Incidental pathologic findings in open resectional gastric bypass specimens with routine cholecystectomy and appendectomy. Surg Obes Relat Dis; 2008 Sep-Oct;4(5):608-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to determine the incidence of abnormal findings of the extirpated, gallbladder, appendix, and distal stomach after gastric bypass surgery.
  • In the gallbladder the sole abnormality, other than cholelithiasis, was an adenomyoma.
  • Other resected findings included five Meckel's diverticula, one bile duct adenoma, and one sigmoid diverticulum.
  • [MeSH-major] Appendectomy / methods. Cecal Diseases / diagnosis. Cholecystectomy / methods. Gallbladder Neoplasms / diagnosis. Gastric Bypass / methods. Incidental Findings. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomyoma / complications. Adenomyoma / diagnosis. Adenomyoma / surgery. Adolescent. Adult. Aged. Cholelithiasis / complications. Cholelithiasis / diagnosis. Cholelithiasis / surgery. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Obesity / complications. Obesity / surgery. Retrospective Studies. Young Adult

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  • (PMID = 18586563.001).
  • [ISSN] 1550-7289
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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63. Iwaki K, Shibata K, Ohta M, Endo Y, Uchida H, Tominaga M, Okunaga R, Kai S, Kitano S: Adenomyomatous hyperplasia of the common bile duct: report of a case. Surg Today; 2008;38(1):85-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomyomatous hyperplasia is most commonly found in the stomach, gallbladder, duodenum, and jejunum, while it is rarely found in the extrahepatic bile duct.
  • A 62-year-old woman was referred to our institution with a diagnosis of common bile duct (CBD) stenosis which had been detected by endoscopic retrograde cholangiopancreatography (ERCP).
  • When a diagnosis of adenomyomatous hyperplasia of the CBD is difficult to make both preoperatively and intraoperatively, then a radical surgical procedure, such as a pancreatoduodenectomy, may be an effective treatment alternative.
  • [MeSH-major] Adenoma / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hyperplasia. Middle Aged. Pancreaticoduodenectomy / methods. Tomography, X-Ray Computed

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  • (PMID = 18085373.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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64. Oki Y, Inoue T, Imura M, Tanaka T, Genma R, Iwabuchi M, Hataya Y, Matsuzawa Y, Iino K, Nishizawa S, Nakamura H: Investigation into the efficacy and safety of octreotide LAR in Japanese patients with acromegaly: Shizuoka study. Endocr J; 2009;56(9):1095-101
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  • A gallbladder polyp was found only in 1 patient but it was uncertain whether OCT-LAR was involved in its development because the patient was not examined before OCT-LAR treatment.
  • [MeSH-minor] Adult. Aged. Delayed-Action Preparations / administration & dosage. Delayed-Action Preparations / adverse effects. Delayed-Action Preparations / therapeutic use. Drug Administration Schedule. Drug Monitoring. Female. Growth Hormone-Secreting Pituitary Adenoma / complications. Growth Hormone-Secreting Pituitary Adenoma / surgery. Humans. Insulin-Like Growth Factor I / analysis. Japan. Male. Middle Aged. Pituitary Neoplasms / complications. Pituitary Neoplasms / surgery. Retrospective Studies. Time Factors. Treatment Outcome. Young Adult

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  • (PMID = 19755754.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Delayed-Action Preparations; 0 / Hormone Antagonists; 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I; RWM8CCW8GP / Octreotide
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65. Fishman DS, Tarnasky PR, Patel SN, Raijman I: Management of pancreaticobiliary disease using a new intra-ductal endoscope: the Texas experience. World J Gastroenterol; 2009 Mar 21;15(11):1353-8
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

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  • Diagnosis of biliary strictures was modified in 20/29 and confirmed to be malignant in 10/23.
  • Of the modified patients, no diagnosis was available in 17.
  • [MeSH-major] Gallbladder Diseases / diagnosis. Pancreatic Diseases / diagnosis
  • [MeSH-minor] Adenoma / pathology. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / pathology. Bile Ducts / pathology. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / pathology. Choledocholithiasis / diagnosis. Endoscopy, Digestive System / instrumentation. Endoscopy, Digestive System / methods. Female. Gallstones / diagnosis. Gallstones / surgery. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • [ISO-abbreviation] World J. Gastroenterol.
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66. Mercado M, Borges F, Bouterfa H, Chang TC, Chervin A, Farrall AJ, Patocs A, Petersenn S, Podoba J, Safari M, Wardlaw J, SMS995B2401 Study Group: A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (long-acting repeatable octreotide) in the primary therapy of patients with acromegaly. Clin Endocrinol (Oxf); 2007 Jun;66(6):859-68
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Delayed-Action Preparations. Drug Administration Schedule. Feasibility Studies. Female. Gallbladder / ultrasonography. Growth Hormone / blood. Growth Hormone-Secreting Pituitary Adenoma / blood. Growth Hormone-Secreting Pituitary Adenoma / drug therapy. Growth Hormone-Secreting Pituitary Adenoma / pathology. Humans. Insulin-Like Growth Factor I / analysis. Magnetic Resonance Imaging. Male. Middle Aged. Pituitary Neoplasms / blood. Pituitary Neoplasms / drug therapy. Pituitary Neoplasms / pathology. Prospective Studies. Treatment Outcome

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  • (PMID = 17465997.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Delayed-Action Preparations; 67763-96-6 / Insulin-Like Growth Factor I; 9002-72-6 / Growth Hormone; RWM8CCW8GP / Octreotide
  • [Other-IDs] NLM/ PMC1974838
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67. Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, Furuse J, Saito H, Tsuyuguchi T, Yamamoto M, Kayahara M, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Hirano S, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg; 2008;15(1):41-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although hepatectomy and/or pancreaticoduodenectomy are preferable for the curative resection of bile duct cancer, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict diagnosis of its local extension.
  • For patients with suspected gallbladder cancer, laparoscopic cholecystectomy is not recommended, and open cholecystectomy should be performed as a rule.
  • When gallbladder cancer invading the subserosal layer or deeper has been detected after simple cholecystectomy, additional resection should be considered.
  • Prognostic factors after resection for gallbladder cancer include the depth of mural invasion; lymph node metastasis; extramural extension, especially into the hepatoduodenal ligament; perineural invasion; and the degree of curability.
  • Pancreaticoduodenectomy is indicated for ampullary carcinoma, and limited operation is also indicated for carcinoma in adenoma.

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  • (PMID = 18274843.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794356
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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68. Sanada Y, Osada S, Tanaka Y, Tokuyama Y, Yoshida K: A Case Report of Intraductal Papillary-Mucinous Neoplasm of the Pancreas Showing Morphologic Transformation during Followup Periods. J Oncol; 2009;2009:373465
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 64-year-old man underwent MRCP for further examination of gallbladder stones and IPMN of branch-type (IPMN-Br) was pointed out.
  • Histologically, the dilated MPD and connecting dilated branch ducts were filled with nodular growth of tumor cells consisting of gastric-type adenoma with pyloric gland-like structures.
  • In the MPD, a transition from gastric-type adenoma to intestinal-type carcinoma was observed.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • (PMID = 19841679.001).
  • [ISSN] 1687-8450
  • [Journal-full-title] Journal of oncology
  • [ISO-abbreviation] J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2762244
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69. Matsusaki S, Maguchi H, Takahashi K, Katanuma A, Osanai M, Urata T, Fukasawa M, Tsuchiya T, Ichiya T, Kurita A, Ambo Y, Nakamura F: [Clinical features of acute acalculous cholecystits-nosocomial manner and community-acquired manner]. Nihon Shokakibyo Gakkai Zasshi; 2008 Dec;105(12):1749-57

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To clarify the clinical features of acute acalculous cholecystitis (AAC), we reviewed 113 cases of AAC experienced from January, 2000 to December, 2007 in regard to patient background, etiology, imaging diagnosis, treatment, and outcomes.
  • On the contrary, mechanical bile stasis caused 37 cases (32.7%), and all but one case developed in a community-acquired manner. mechanical bile stasis included 9 cases of biliary tract neoplasm (5, cystic duct cancer; 3, gallbladder cancer; 1, papillary adenoma).

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  • (PMID = 19057160.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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70. Su DH, Liao KM, Chen HW, Chang TC: Long-term primary medical therapy with somatostatin analogs in acromegaly. J Formos Med Assoc; 2006 Aug;105(8):664-9
MedlinePlus Health Information. consumer health - Pituitary Tumors.

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  • She received 8 years of octreotide treatment followed by 6 years of PR lanreotide resulting in subnormal GH level and gallbladder sludge.

  • Genetic Alliance. consumer health - Acromegaly.
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  • (PMID = 16935768.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Peptides, Cyclic; 118992-92-0 / lanreotide; 12629-01-5 / Human Growth Hormone; 51110-01-1 / Somatostatin; RWM8CCW8GP / Octreotide
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71. Chang HJ, Oh SN, Park MY, Rha SE, Choi BG: Fraudulent retouching of digital radiographic images--a potential risk. Clin Radiol; 2010 Dec;65(12):967-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: Ten representative key images were selected of aortic dissection, hepatocellular carcinoma, renal cell carcinoma, colon cancer, liver metastasis, hepatic cyst, gallbladder stones, splenic artery aneurysm, adrenal adenoma, and stomach cancer from abdominal computed tomography (CT) imaging performed in 2008.
  • Radiologists were requested to make a diagnosis for the 10 images, and were then asked to identify possible retouched images.
  • None of the reviewers recognized that some images were retouched during diagnosis.
  • The rate of correct diagnosis was 90% (range 71.7-100%).
  • The time to diagnosis and the time to detection of the retouched images were 15 (14-17) and 6 (5-7) min, respectively.

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  • [Copyright] Copyright © 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 21070899.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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72. Galitskiĭ MV, Khomeriki SG, Nikiforov PA: [Expression of proliferation and apoptosis markers in neoplasms of colon mucosa after cholecystectomy]. Eksp Klin Gastroenterol; 2009;(5):28-32
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  • Fifty patients (40 with retained function of gallbladder and 10 patients with cholecystectomy) histologically diagnosed as proximal colon adenoma or adenocarcinoma were included into the study.
  • Thus, in benign colorectal tumors at the patients with retained function of gallbladder intensifying of epithelial cells proliferation is not accompanied with intensifying of apoptosis, and in malignant tumors a complete supression of apoptosis is observed.

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  • (PMID = 20205327.001).
  • [ISSN] 1682-8658
  • [Journal-full-title] Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
  • [ISO-abbreviation] Eksp Klin Gastroenterol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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73. Miyazaki M, Takada T, Miyakawa S, Tsukada K, Nagino M, Kondo S, Furuse J, Saito H, Tsuyuguchi T, Chijiiwa K, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Pancreatic Surgery, Japan Society of Clinical Oncology: Risk factors for biliary tract and ampullary carcinomas and prophylactic surgery for these factors. J Hepatobiliary Pancreat Surg; 2008;15(1):15-24

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It has been reported that pancreaticobiliary maljunction (PBM) with bile duct dilatation is a risk factor for gallbladder cancer and bile duct cancer, while PBM without bile duct dilatation is a risk factor for gallbladder cancer.
  • Thus, in the former group, a prophylactic excision of the common bile duct and gallbladder should be recommended, while in the later group, a prophylactic cholecystectomy without bile duct resection may be the appropriate surgical procedure.
  • Adenoma and dysplasia have been regarded as precancerous lesions of gallbladder cancer.
  • A polypoid lesion of the gallbladder that is sessile, has a diameter greater than 10 mm, and /or grows rapidly, is highly likely to be cancerous and should be resected.
  • Although gallstones seem to be closely associated with gallbladder cancer, there is no evidence of a direct causal relationship between gallstones and gallbladder cancer.
  • Controversy remains as to whether adenomyomatosis of the gallbladder and porcelain gallbladder are associated with gallbladder cancer.
  • With respect to ampullary carcinoma, adenoma of the ampulla is considered to be a precancerous lesion.

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  • (PMID = 18274840.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Number-of-references] 39
  • [Other-IDs] NLM/ PMC2794357
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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74. Ge D, You Z: Expression of interleukin-17RC protein in normal human tissues. Int Arch Med; 2008;1(1):19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: IL-17RC expression in 51 normal human tissues and two benign tumors (i.e., lymphangioma and parathyroid adenoma) on the tissue microarrays was determined by immunohistochemical staining, using two polyclonal antibodies against IL-17RC.
  • IL-17RC protein was expressed in many cell types including the myocardial cells, vascular and lymphatic endothelial cells, glandular cells (of the adrenal, parathyroid, pituitary, thyroid, pancreas, parotid salivary, and subepidermal glands), epithelial cells (of the esophagus, stomach, intestine, anus, renal tubule, breast, cervix, Fallopian tube, epididymis, seminal vesicle, prostate, gallbladder, bronchus, lung, and skin), oocytes in the ovary, Sertoli cells in the testis, motor neurons in the spinal cord, autonomic ganglia and nerves in the intestine, skeletal muscle cells, adipocytes, articular chondrocytes, and synovial cells.

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  • (PMID = 18928529.001).
  • [ISSN] 1755-7682
  • [Journal-full-title] International archives of medicine
  • [ISO-abbreviation] Int Arch Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2596096
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75. Wong CS, Meng WC: Feasibility study on single-port access (SPA) laparoscopic cholecystectomy using transanal endoscopic microsurgery (TEM) instruments. Minim Invasive Ther Allied Technol; 2010 Dec;19(6):364-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Transanal endoscopic microsurgery (TEM) is a procedure for the treatment of rectal villous adenoma and early rectal tumours.
  • One gallbladder was perforated during the operation and the others were delivered intact.

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  • (PMID = 20964561.001).
  • [ISSN] 1365-2931
  • [Journal-full-title] Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy
  • [ISO-abbreviation] Minim Invasive Ther Allied Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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76. Schemmer P, Friess H, Hinz U, Mehrabi A, Kraus TW, Z'graggen K, Schmidt J, Uhl W, Büchler MW: Stapler hepatectomy is a safe dissection technique: analysis of 300 patients. World J Surg; 2006 Mar;30(3):419-30
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During this period endo GIA vascular staplers were used for parenchymal transection in 300 cases of primary (22%) and metastatic (57%) liver cancer, benign diseases (adenoma, focal nodular hyperplasia [FNH], cysts) (14%), gallbladder carcinoma (2%), and other tumors (5%).

  • MedlinePlus Health Information. consumer health - After Surgery.
  • MedlinePlus Health Information. consumer health - Liver Diseases.
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  • (PMID = 16467982.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Yi B, Somasundar P, Espat NJ: Novel laparoscopic bipolar radiofrequency energy technology for expedited hepatic tumour ablation. HPB (Oxford); 2009 Mar;11(2):135-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Four lesions (in two patients) represented locally advanced symptomatic gallbladder cancer invading the liver bed or symptomatic intrahepatic liver metastases from gallbladder cancer.
  • One lesion was benign hepatic adenoma.

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  • (PMID = 19590637.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2697874
  • [Keywords] NOTNLM ; bipolar radiofrequency ablation / laparoscopy / liver tumour
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78. Patel CB, Ramos-Valadez DI, Ragupathi M, Haas EM: Single incision laparoscopic-assisted right hemicolectomy: technique and application (with video). Surg Laparosc Endosc Percutan Tech; 2010 Oct;20(5):e146-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Most commonly employed for surgery of the gallbladder and appendix, single-incision laparoscopic surgery (SILS) is rapidly evolving in the field of minimally invasive surgery.
  • [MeSH-minor] Adenoma, Villous / surgery. Colonic Neoplasms / surgery. Female. Humans. Middle Aged

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  • (PMID = 20975489.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] United States
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79. Konishi M, Kinoshita T, Nakagohri T, Takahashi S, Gotohda N, Ryu M: Pancreas-sparing duodenectomy for duodenal neoplasms including malignancies. Hepatogastroenterology; 2007 Apr-May;54(75):753-7
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODOLOGY: The present study investigated 16 patients who underwent PSD for duodenal neoplasms including adenoma, cancer, carcinoid and non-epithelial tumor.
  • Although 1 patient with gallbladder cancer died postoperatively due to the results of a concomitant operation, no postoperative deaths or re-operations related to PSD were encountered.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postoperative Complications / diagnosis. Treatment Outcome

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  • (PMID = 17591055.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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80. Kim HG: [Biliary cystic neoplasm: biliary cystadenoma and biliary cystadenocarcinoma]. Korean J Gastroenterol; 2006 Jan;47(1):5-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most biliary cystic tumors arise from intrahepatic bile duct and 10-20% arise from extrahepatic bile duct like common hepatic duct, common bile duct, and gallbladder.
  • The epithelial lining of cystadenocarcinoma exhibits cellular atypia, mitotic activity, and infiltrative growth, but part of lining epithelium retain the feature of cystadenoma, which support the adenoma-carcinoma sequence.

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  • (PMID = 16434863.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 64
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81. Constantea N, Axente D, Micu B: A case of pyloric-type gallbladder adenoma. J Gastrointestin Liver Dis; 2008 Mar;17(1):116-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pyloric-type gallbladder adenoma.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

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  • [CommentIn] J Gastrointestin Liver Dis. 2008 Sep;17(3):251-3 [18836615.001]
  • (PMID = 18392262.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Romania
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