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1
adenoma of the colon 2005:2010[pubdate] *count=100
1408 results
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Items 1 to 100 of about 1408
1.
Tanaka T:
Colorectal carcinogenesis: Review of human and experimental animal studies.
J Carcinog
; 2009;8:5
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[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
The focus is on human and murine colorectal carcinogenesis and the histogenesis of this malignant
disorder
.
A summary of a model of colitis-associated
colon
tumorigenesis (an AOM/DSS model) will also be presented.
The earliest phases of colorectal oncogenesis occur in the normal mucosa, with a
disorder
of cell replication.
The large majority of colorectal malignancies develop from an
adenomatous polyp
(
adenoma
).
Carcinomas usually originate from pre-existing
adenomas
, but this does not imply that all
polyps
undergo malignant changes and does not exclude
de
novo oncogenesis.
Besides
adenomas
, there are other types of pre-neoplasia, which include hyperplastic
polyps
, serrated
adenomas
, flat
adenomas
and dysplasia that occurs in the inflamed
colon
in associated with inflammatory bowel disease.
Colorectal neoplasms and/or pre-neoplasms can be prevented by interfering with the various steps of oncogenesis, which begins with uncontrolled epithelial cell replication, continues with the formation of
adenomas
and eventually evolves into malignancy.
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[ISSN]
1477-3163
[Journal-full-title]
Journal of carcinogenesis
[ISO-abbreviation]
J Carcinog
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2678864
2.
Gordon PV, Paxton JB, Fox NS:
A methodology for distinguishing divergent cell fates within a common progenitor population: adenoma- and neuroendocrine-like cells are confounders of rat ileal epithelial cell (IEC-18) culture.
BMC Cell Biol
; 2005;6(1):2
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[Title]
A methodology for distinguishing divergent cell fates within a common progenitor population:
adenoma
- and neuroendocrine-like cells are confounders of rat ileal epithelial cell (IEC-18) culture.
BACKGROUND: IEC-18 cells are a
non
-transformed, immortal cell line derived from juvenile rat ileal crypt cells.
We then confirmed the cell-
specific
phenotype by immunolocalization of proteins corresponding to those genes.
The majority of IEC-18 cells in SFM alone had a loss in expression of the
adenomatous
polyposis coli (APC) gene at the mRNA and protein levels, consistent with
adenoma
-like transformation.
The most common fate switch that we were able to detect correlates with a down regulation of the APC gene and transformation into an
adenoma
-like phenotype.
[MeSH-minor]
Adenoma
/ pathology. Animals. Carcinoma, Neuroendocrine / pathology. Gene Expression Profiling. Gene Expression Regulation. Genes, APC. Methods. Phenotype. Rats
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[ISSN]
1471-2121
[Journal-full-title]
BMC cell biology
[ISO-abbreviation]
BMC Cell Biol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC547914
3.
Freeman HJ:
Heterogeneity of colorectal adenomas, the serrated adenoma, and implications for screening and surveillance.
World J Gastroenterol
; 2008 Jun 14;14(22):3461-3
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[Title]
Heterogeneity of colorectal
adenomas
, the serrated
adenoma
, and implications for screening and surveillance.
Current algorithms for screening and surveillance for
colon
cancer are valuable, but may be limited by the underlying nature of the targeted neoplastic lesions.
Although part of the success
of adenoma
removal relates to interruption of so-called "
adenoma
-carcinoma sequence", an alternate serrated pathway to
colon
cancer may pose difficulties with the ultimate results achieved by traditional colonoscopic methods.
The endpoint carcinoma in this unique pathway may be derived from a dysplastic serrated
adenoma
.
These tend to be located primarily in the right
colon
, especially in females, and are frequently associated with co-existent
colon
cancer.
Unfortunately, however, there are few, if any, other identifiable risk factors, including age or family history
of colon
polyps
or
colon
cancer.
Moreover, this alternate serrated pathway may itself also be quite biologically heterogeneous as reflected in sessile serrated
adenomas
(SSA) with virtually exclusive molecular signatures defined by the presence of either BRAF or KRAS mutations.
Screening algorithms in the future may need to be modified and individualized, depending on new information that likely will emerge on the natural history of these biologically heterogeneous lesions that differs from traditional
adenomatous polyps
.
[MeSH-major]
Adenoma
/ diagnosis. Algorithms. Colorectal Neoplasms / diagnosis. Mass Screening / methods
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NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[Cites]
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]
[Cites]
N Engl J Med. 1988 Sep 1;319(9):525-32
[
2841597.001
]
(PMID = 18567071.001).
[ISSN]
1007-9327
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
China
[Chemical-registry-number]
0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
[Other-IDs]
NLM/ PMC2716605
Advertisement
4.
Toth B, Coles M:
Inhibition of large intestinal cancers by celecoxib using a serial sacrifice technique.
In Vivo
; 2006 Jul-Aug;20(4):453-7
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Histopathologically, the tumors were diagnosed as polypoid
adenomas
and adenocarcinomas of the cecum,
colon
and rectum.
[MeSH-minor]
1,2-Dimethylhydrazine / administration & dosage. 1,2-Dimethylhydrazine / pharmacology. Adenocarcinoma / chemically induced. Adenocarcinoma / pathology.
Adenoma
/ chemically induced.
Adenoma
/ pathology. Administration, Oral. Animals. Animals, Outbred Strains. Anti-Inflammatory Agents,
Non
-Steroidal / administration & dosage. Carcinogens / administration & dosage. Carcinogens / pharmacology. Celecoxib. Female. Incidence. Injections, Subcutaneous. Mice. Survival Rate. Time Factors
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.
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.
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(PMID = 16900774.001).
[ISSN]
0258-851X
[Journal-full-title]
In vivo (Athens, Greece)
[ISO-abbreviation]
In Vivo
[Language]
eng
[Grant]
United States / NCCIH NIH HHS / AT / 1R21 AT001739
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
Greece
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Carcinogens; 0 / Cyclooxygenase Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; IX068S9745 / 1,2-Dimethylhydrazine; JCX84Q7J1L / Celecoxib
5.
Dubé C, Rostom A, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D, U.S. Preventive Services Task Force:
The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force.
Ann Intern Med
; 2007 Mar 6;146(5):365-75
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DATA SYNTHESIS: Regular use of aspirin reduced the incidence of
colonic adenomas
in RCTs (relative risk [RR], 0.82 [95% CI, 0.7 to 0.95]), case-control studies (RR, 0.87 [CI, 0.77 to 0.98]), and cohort studies (RR, 0.72 [CI, 0.61 to 0.85]).
CONCLUSIONS: Aspirin appears to be effective at reducing the incidence of
colonic
adenoma
and colorectal cancer, especially if used in high doses for more than 10 years.
[MeSH-major]
Anti-Inflammatory Agents,
Non
-Steroidal / therapeutic use. Aspirin / therapeutic use. Colorectal Neoplasms / prevention & control. Primary Prevention
[MeSH-minor]
Adenoma
/ prevention & control. Adult. Cardiovascular Diseases / chemically induced.
Colonic Polyps
/ prevention & control. Female. Gastrointestinal Diseases / chemically induced. Humans. Incidence. Male. United States / epidemiology
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[CommentIn]
ACP J Club. 2007 Jul-Aug;147(1):15-6
[
17608380.001
]
[CommentIn]
Gastroenterology. 2007 Aug;133(2):717-8
[
17681190.001
]
[CommentIn]
Ann Intern Med. 2007 Nov 6;147(9):674; author reply 674-5
[
17975195.001
]
[SummaryForPatientsIn]
Ann Intern Med. 2007 Mar 6;146(5):I35
[
17339615.001
]
(PMID = 17339622.001).
[ISSN]
1539-3704
[Journal-full-title]
Annals of internal medicine
[ISO-abbreviation]
Ann. Intern. Med.
[Language]
eng
[Publication-type]
Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; R16CO5Y76E / Aspirin
[Number-of-references]
61
6.
Croce MV, Sálice VC, Lacunza E, Segal-Eiras A:
Alpha 1-acid glycoprotein (AGP): a possible carrier of sialyl lewis X (slewis X) antigen in colorectal carcinoma.
Histol Histopathol
; 2005 01;20(1):91-7
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MATERIALS AND METHODS: tissue and serum samples from 88 patients with colorectal cancer, 22
adenomas
and 23 normal were included.
[MeSH-minor]
Adenoma
/ immunology. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / immunology.
Colon
/ immunology.
Colon
/ metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged
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(PMID = 15578427.001).
[ISSN]
0213-3911
[Journal-full-title]
Histology and histopathology
[ISO-abbreviation]
Histol. Histopathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Spain
[Chemical-registry-number]
0 / 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine; 0 / Antibodies, Monoclonal; 0 / Oligosaccharides; 0 / Orosomucoid
7.
Oset P, Jasińska A, Szcześniak P, Orszulak-Michalak D, Talar-Wojnarowska R, Małecka-Panas E:
[Analysis of serum gastrin levels in patients with adenomatous polyps of the colon].
Pol Merkur Lekarski
; 2009 May;26(155):458-61
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[Title]
[Analysis of serum gastrin levels in patients with
adenomatous polyps
of the
colon
].
Adenomatous polyps
are known risk factor
of colon
cancer.
Gastrin is a peptide hormone involved in the growth of both normal and malignant intestinal tissue, which probably may promote progression through
the adenoma
-carcinoma sequence.
AIM OF OUR STUDY: To assess the association between serum gastrin levels and size, type and localization of
colonic adenomas
.
MATERIAL AND METHODS: The study included 60 patients with
adenomatous polyps
of the
colon
and 30 healthy volunteers.
RESULTS: We observed higher serum gastrin levels in patients with
colonic adenomas
compared to control group (59.65 pg/ml vs. 46.89 pg/ml; p < 0.05).
There was no association between gastrin levels and size, number, localisation and histologic type of
polyps
(p > 0.05).
CONCLUSION: Despite of elevated serum levels in patients with
colonic adenomas
we did not observe the association between gastrin levels and size, grade of dysplasia and histologic type of
polyps
.
The exact role of hipergastrinemia in process
of colon
carcinogenesis remains to be determined.
[MeSH-major]
Adenomatous Polyps
/ blood. Gastrins / blood
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(PMID = 19606697.001).
[ISSN]
1426-9686
[Journal-full-title]
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
[ISO-abbreviation]
Pol. Merkur. Lekarski
[Language]
pol
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Poland
[Chemical-registry-number]
0 / Gastrins
8.
Ono S, Fujishiro M, Goto O, Kodashima S, Omata M:
Submerging endoscopic submucosal dissection leads to successful en bloc resection of colonic laterally spreading tumor with submucosal fat.
Gut Liver
; 2008 Dec;2(3):209-12
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The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Submerging endoscopic submucosal dissection leads to successful
en
bloc resection of
colonic
laterally spreading tumor with submucosal fat.
A 72-year-old female with a
colonic
laterally spreading tumor (LST) was referred to our department.
A total colonoscopy revealed a large nongranular LST, 30 mm in diameter, in the ascending
colon
.
The lesion was successfully resected
en
bloc without complications.
The pathological examination indicated the curative resection of a tubulovillous
adenoma
.
We propose that a submerged ESD could also be an effective procedure for
colonic
neoplasms with submucosal fat by avoiding blurring of the endoscopic view.
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[Cites]
Clin Gastroenterol Hepatol. 2007 Jun;5(6):678-83; quiz 645
[
17466600.001
]
[Cites]
AJR Am J Roentgenol. 2003 Sep;181(3):781-4
[
12933481.001
]
[Cites]
Endoscopy. 1998 May;30(4):351-5
[
9689507.001
]
[Cites]
Gastrointest Endosc. 2006 Jan;63(1):178-83
[
16377346.001
]
(PMID = 20485649.001).
[ISSN]
2005-1212
[Journal-full-title]
Gut and liver
[ISO-abbreviation]
Gut Liver
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Korea (South)
[Other-IDs]
NLM/ PMC2871645
[Keywords]
NOTNLM ; Adipose tissue / Colonic neoplasms / Colonoscopy / Resection / Submucosa
9.
Ye C, Shrubsole MJ, Cai Q, Ness R, Grady WM, Smalley W, Cai H, Washington K, Zheng W:
Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas.
Oncol Rep
; 2006 Aug;16(2):429-35
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[Title]
Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in
non
-neoplastic mucosa of patients with and without colorectal
adenomas
.
CpG island methylation has been observed in aberrant crypt foci (ACF) and
adenomas
in
the colon
, implicating it in the earliest aspects
of colon
cancer formation.
In addition, some investigators have identified an age-related increase in DNA methylation of the ESR1 locus in
the colon
mucosa, suggesting that DNA methylation may be a pre-neoplastic change that increases the risk
of colon
adenomas
and
colon
cancer.
We investigated the methylation status in the promoter regions of the CDKN2A/p16, hMLH1, and MGMT genes in human
non
-neoplastic rectal mucosa and evaluated whether these methylation markers may predict the presence of
adenomatous polyps
in
the colon
.
The promoter methylation patterns of these genes were examined in rectal biopsies (mucosa samples) of 97 colorectal
adenoma
cases and 94 healthy controls using methylation-
specific
PCR (MSP) assays.
The methylation status of these genes in rectal mucosa biopsies detected by MSP assays may not distinguish between patients with and without
adenomas
in
the colon
.
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(PMID = 16820927.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / P50 CA95103; United States / NCI NIH HHS / CA / R01CA97386
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
Greece
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
10.
Bouzourene H, Sandmeier D:
[Sessile serrated adenoma: an underdiagnosed colonic polyp].
Rev Med Suisse
; 2007 Jul 4;3(118):1702-4
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[Title]
[Sessile serrated
adenoma
: an underdiagnosed
colonic polyp
].
[Transliterated title]
L'adénome dentelé sessile, un
polype
colique à ne pas méconnaître.
Serrated
polyps
of the
colon
represent a large morphological spectrum of lesions.
They comprise the hyperplastic
polyp
considered as an innocuous lesion for many years, the traditional serrated
adenoma
presenting a potential of cancerisation and the recently described the sessile serrated
adenoma
which seems to be a potential precursor of
colonic
cancer with microsatellite instability and which probably uses an alternate
polyp
-neoplasia pathway in addition to the classical
adenoma
-carcinoma sequence.
The aims of this article intend to inform of new concept of
colonic
carcinogenesis, to be aware of a serrated
colonic polyp
entity recently described and to use a same nomenclature to facilitate the dialogue between pathologists and clinicians.
[MeSH-major]
Adenoma
/ pathology.
Colonic
Neoplasms / pathology.
Colonic Polyps
/ pathology
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(PMID = 17726906.001).
[ISSN]
1660-9379
[Journal-full-title]
Revue médicale suisse
[ISO-abbreviation]
Rev Med Suisse
[Language]
fre
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Switzerland
[Number-of-references]
10
11.
Tan KL, Wilson S, O'Neill C, Gordon D, Napier S:
Something not quite right: Gardner syndrome diagnosed by multiple cutaneous lesions and genetic testing.
Surgeon
; 2005 Dec;3(6):412-5
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Gardner syndrome is a variant of familial
adenomatous
polyposis characterized by intestinal
adenomatous polyps
, which can progress to adenocarcinoma, and a variety of extraintestinal manifestations, including skin cysts, osteomas, soft tissue fibrous tumours and a characteristic ocular lesion.
Gardner syndrome was considered only after excision of subcutaneous fibrous tumours from the mastoid region and paraspinal area and was confirmed by genetic testing in spite of the patient's refusal to undergo
colonic
endoscopic examination.
Subsequent resection revealed approximately 70
adenomatous colonic polyps
in
the colon
and rectum but no invasive tumour, highlighting the benefits of genetic testing in treatment planning.
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(PMID = 16353862.001).
[ISSN]
1479-666X
[Journal-full-title]
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
[ISO-abbreviation]
Surgeon
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Scotland
12.
Sacher-Huvelin S, Coron E, Gaudric M, Planche L, Benamouzig R, Maunoury V, Filoche B, Frédéric M, Saurin JC, Subtil C, Lecleire S, Cellier C, Coumaros D, Heresbach D, Galmiche JP:
Colon capsule endoscopy vs. colonoscopy in patients at average or increased risk of colorectal cancer.
Aliment Pharmacol Ther
; 2010 Nov;32(9):1145-53
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[Title]
Colon
capsule endoscopy vs. colonoscopy in patients at average or increased risk of colorectal cancer.
BACKGROUND:
Colon
capsule endoscopy (CCE) is a new,
non
-invasive technology.
Colon
cleanliness was excellent or good in 52% of cases at CCE.
CCE accuracy for the detection of
polyps
≥ 6 mm was 39% (95% CI 30-48) for sensitivity, 88% (95% CI 85-91) for specificity, 47% (95% CI 37-57) for positive predictive value and 85% (95% CI 82-88) for negative predictive value.
CCE accuracy was better for the detection of advanced
adenoma
, in patients with good or excellent cleanliness and after re-interpretation of the CCE videos by an independent expert panel.
Further studies should pay attention to
colonic
preparation (Clinicaltrial.gov number NCT00436514).
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.
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.
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[Copyright]
© 2010 Blackwell Publishing Ltd.
(PMID = 21039676.001).
[ISSN]
1365-2036
[Journal-full-title]
Alimentary pharmacology & therapeutics
[ISO-abbreviation]
Aliment. Pharmacol. Ther.
[Language]
eng
[Databank-accession-numbers]
ClinicalTrials.gov/ NCT00436514
[Publication-type]
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
England
13.
Galamb O:
[mRNA expression analysis and classification of colonic biopsy samples using oligonucleotide and cDNA microarray techniques].
Orv Hetil
; 2008 Jul 20;149(29):1373-7
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[Title]
[mRNA expression analysis and classification of
colonic
biopsy samples using oligonucleotide and cDNA microarray techniques].
We have shown that the sequential overexpression of osteopontin and osteonectin mRNAs and proteins significantly correlates with the progression of the colorectal
adenoma
-dysplasia-carcinoma sequence.
We have identified and validated ten novel markers with continuously increasing mRNA expression in line with
the adenoma
-dysplasia-carcinoma transition.
We have identified the top 27, 13 and 10 genes associated with
adenoma
, colorectal cancer, and inflammatory bowel diseases.
[MeSH-major]
Biopsy. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / metabolism.
Colon
/ metabolism. Oligonucleotide Array Sequence Analysis. Osteonectin / metabolism. Osteopontin / metabolism. RNA, Messenger / metabolism
[MeSH-minor]
Adenoma
/ genetics.
Adenoma
/ metabolism. Carcinoma / genetics. Carcinoma / metabolism. Colorectal Neoplasms / genetics. Colorectal Neoplasms / metabolism. Gene Expression. Humans. Inflammatory Bowel Diseases / genetics. Inflammatory Bowel Diseases / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sequence Analysis, DNA. Up-Regulation
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(PMID = 18617470.001).
[ISSN]
0030-6002
[Journal-full-title]
Orvosi hetilap
[ISO-abbreviation]
Orv Hetil
[Language]
hun
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Hungary
[Chemical-registry-number]
0 / Osteonectin; 0 / RNA, Messenger; 106441-73-0 / Osteopontin
14.
Ragupathi M, Ramos-Valadez DI, Pedraza R, Haas EM:
Robotic-assisted single-incision laparoscopic partial cecectomy.
Int J Med Robot
; 2010 Sep;6(3):362-7
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BACKGROUND: Single-incision laparoscopic surgery is an emerging approach in the field of minimally invasive
colon
and rectal surgery.
Pathology revealed a sessile tubular
adenoma of
the cecum.
[MeSH-major]
Cecum / surgery. Intestinal
Polyps
/ surgery. Laparoscopy / methods. Robotics / instrumentation. Robotics / methods
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[Copyright]
Copyright 2010 John Wiley & Sons, Ltd.
(PMID = 20665713.001).
[ISSN]
1478-596X
[Journal-full-title]
The international journal of medical robotics + computer assisted surgery : MRCAS
[ISO-abbreviation]
Int J Med Robot
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
15.
Hu Y, Lu X, Luo G:
Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice.
World J Gastroenterol
; 2010 Mar 28;16(12):1482-6
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RESULTS: Recql5 deficiency in Apc(min/+) mice resulted in a significant increase in the tumor incidence in both
the colon
(P = 0.0162) and the small intestine (P < 0.01).
Importantly, since mouse Recql5 and human RECQL5 are highly conserved, these findings also suggest that RECQL5 may be a tumor suppressor for human
colon
cancer.
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[Cites]
Nat Rev Genet. 2001 Mar;2(3):196-206
[
11256071.001
]
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J Biol Chem. 2009 Aug 28;284(35):23197-203
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[
15831450.001
]
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16195750.001
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18419580.001
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18538487.001
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[
18987339.001
]
[Cites]
Trends Mol Med. 2002 Apr;8(4):179-86
[
11927276.001
]
(PMID = 20333788.001).
[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P20 CA103736; United States / NCI NIH HHS / CA / R01 CA88939
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Tumor Suppressor Proteins; EC 3.6.4.12 / RecQ Helicases; EC 5.99.- / Recql5 protein, mouse
[Other-IDs]
NLM/ PMC2846253
16.
Khoo RE:
Transanal excision of a rectal adenoma using single-access laparoscopic port.
Dis Colon Rectum
; 2010 Jul;53(7):1078-9
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[Title]
Transanal excision of a rectal
adenoma
using single-access laparoscopic port.
Through this port, insufflation with gas maintained exposure of the surgical site, a 30-degree 5-mm camera, a grasper, and electrocautery were used to remove a large villous
adenoma
.
[MeSH-major]
Adenoma
, Villous / surgery. Colectomy / methods. Laparoscopes. Laparoscopy / methods. Rectal Neoplasms / surgery
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(PMID = 20551763.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
17.
Boissan M, De Wever O, Lizarraga F, Wendum D, Poincloux R, Chignard N, Desbois-Mouthon C, Dufour S, Nawrocki-Raby B, Birembaut P, Bracke M, Chavrier P, Gespach C, Lacombe ML:
Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells.
Cancer Res
; 2010 Oct 1;70(19):7710-22
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We silenced NM23-H1 expression in human hepatoma and
colon
carcinoma cells and methodologically investigated effects on cell-cell adhesion, migration, invasion, and signaling linked to cancer progression.
Analysis of NM23-H1 expression in clinical specimens revealed high expression in premalignant lesions (liver cirrhosis and
colon adenoma
) and the central body of primary liver or
colon
tumors, but downregulation at the invasive front of tumors.
[MeSH-minor]
Actins / metabolism. Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Breast Neoplasms / genetics. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cell Line, Tumor. Cell Movement / genetics.
Colonic
Neoplasms / genetics.
Colonic
Neoplasms / metabolism.
Colonic
Neoplasms / pathology. Cytoskeleton / metabolism. Cytoskeleton / pathology. Gene Silencing. Humans. Liver Neoplasms / genetics. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Matrix Metalloproteinase 14 / metabolism. Neoplasm Invasiveness. Wnt Proteins / metabolism
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[Copyright]
© 2010 AACR.
(PMID = 20841469.001).
[ISSN]
1538-7445
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Actins; 0 / NM23 Nucleoside Diphosphate Kinases; 0 / Wnt Proteins; EC 2.7.4.6 / NME1 protein, human; EC 3.4.24.80 / Matrix Metalloproteinase 14
18.
Van Gossum A, Munoz-Navas M, Fernandez-Urien I, Carretero C, Gay G, Delvaux M, Lapalus MG, Ponchon T, Neuhaus H, Philipper M, Costamagna G, Riccioni ME, Spada C, Petruzziello L, Fraser C, Postgate A, Fitzpatrick A, Hagenmuller F, Keuchel M, Schoofs N, Devière J:
Capsule endoscopy versus colonoscopy for the detection of polyps and cancer.
N Engl J Med
; 2009 Jul 16;361(3):264-70
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[Title]
Capsule endoscopy versus colonoscopy for the detection of
polyps
and cancer.
BACKGROUND: An ingestible capsule consisting of an endoscope equipped with a video camera at both ends was designed to explore
the colon
.
This study compared capsule endoscopy with optical colonoscopy for the detection of colorectal
polyps
and cancer.
METHODS: We performed a prospective, multicenter study comparing capsule endoscopy with optical colonoscopy (the standard for comparison) in a cohort of patients with known or suspected
colonic
disease for the detection of colorectal
polyps
or cancer.
Patients underwent an adapted
colon
preparation, and
colon
cleanliness was graded from poor to excellent.
We computed the sensitivity and specificity of capsule endoscopy for
polyps
, advanced
adenoma
, and cancer.
The sensitivity and specificity of capsule endoscopy for detecting
polyps
that were 6 mm in size or bigger were 64% (95% confidence interval [CI], 59 to 72) and 84% (95% CI, 81 to 87), respectively, and for detecting advanced
adenoma
, the sensitivity and specificity were 73% (95% CI, 61 to 83) and 79% (95% CI, 77 to 81), respectively.
For all lesions, the sensitivity of capsule endoscopy was higher in patients with good or excellent
colon
cleanliness than in those with fair or poor
colon
cleanliness.
Mild-to-moderate adverse events were reported in 26 patients (7.9%) and were mostly related to
the colon
preparation.
CONCLUSIONS: The use of capsule endoscopy of the
colon
allows visualization of the
colonic
mucosa in most patients, but its sensitivity for detecting
colonic
lesions is low as compared with the use of optical colonoscopy. (ClinicalTrials.gov number, NCT00604162. )
[MeSH-major]
Capsule Endoscopy.
Colonic Polyps
/ diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis
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.
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[Copyright]
2009 Massachusetts Medical Society
[CommentIn]
J R Coll Physicians Edinb. 2011 Jun;41(2):124-5
[
21677917.001
]
[CommentIn]
Ann Intern Med. 2009 Nov 17;151(10):JC5-11
[
19920256.001
]
[CommentIn]
Gastroenterology. 2010 Mar;138(3):1200-2; discussion 1202
[
20100447.001
]
[CommentIn]
N Engl J Med. 2009 Oct 15;361(16):1608; author reply 1609-10
[
19842249.001
]
[CommentIn]
N Engl J Med. 2009 Jul 16;361(3):300-1
[
19605836.001
]
[CommentIn]
N Engl J Med. 2009 Oct 15;361(16):1608-9; author reply 1609-10
[
19828540.001
]
[ErratumIn]
N Engl J Med. 2009 Sep 17;361(12):1220. Navas, Miguel Munoz [corrected to Munoz-Navas, Miguel]
(PMID = 19605831.001).
[ISSN]
1533-4406
[Journal-full-title]
The New England journal of medicine
[ISO-abbreviation]
N. Engl. J. Med.
[Language]
eng
[Databank-accession-numbers]
ClinicalTrials.gov/ NCT00604162
[Publication-type]
Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
United States
19.
Pandak N, Tomić-Paradzik M, Krizanović B, Fornet-Sapcevski J:
[The importance of Streptococcus bovis systemic infections].
Lijec Vjesn
; 2006 Jul-Aug;128(7-8):206-9
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He was an older man, who had undergone prostatectomy due prostatic
adenoma
several years before.
Colon
endoscopy was performed in both patients and it revealed
colon
polyps
.
Since Streptococcus bovis infections are associated with
colon
carcinoma, it is imperative to perform colonoscopy in each patient suffering infection with this germ, and to consider him as a high risk patient for developing
colon
cancer.
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.
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(PMID = 17087134.001).
[ISSN]
0024-3477
[Journal-full-title]
Lijec̆nic̆ki vjesnik
[ISO-abbreviation]
Lijec Vjesn
[Language]
hrv
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Croatia
20.
Schick V, Franzius C, Beyna T, Oei ML, Schnekenburger J, Weckesser M, Domschke W, Schober O, Heindel W, Pohle T, Juergens KU:
Diagnostic impact of 18F-FDG PET-CT evaluating solid pancreatic lesions versus endosonography, endoscopic retrograde cholangio-pancreatography with intraductal ultrasonography and abdominal ultrasound.
Eur J Nucl Med Mol Imaging
; 2008 Oct;35(10):1775-85
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PET-CT revealed cervical lymphonodal metastasis from occult bronchogenic carcinoma and a tubular
colon adenoma
with intermediate dysplasia on polypectomy, respectively.
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Pancreatology. 2005;5(4-5):398-402
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]
(PMID = 18481063.001).
[ISSN]
1619-7070
[Journal-full-title]
European journal of nuclear medicine and molecular imaging
[ISO-abbreviation]
Eur. J. Nucl. Med. Mol. Imaging
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Comparative Study; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
21.
Matsumoto T, Esaki M, Fujisawa R, Nakamura S, Yao T, Iida M:
Chromoendoscopy, narrow-band imaging colonoscopy, and autofluorescence colonoscopy for detection of diminutive colorectal neoplasia in familial adenomatous polyposis.
Dis Colon Rectum
; 2009 Jun;52(6):1160-5
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[Title]
Chromoendoscopy, narrow-band imaging colonoscopy, and autofluorescence colonoscopy for detection of diminutive colorectal neoplasia in familial
adenomatous
polyposis.
METHODS: Thirteen patients with
adenomatous
polyposis were examined by total colonoscopy using an instrument that incorporated both narrow-band and autofluorescence imaging.
Narrow-band imaging depicted a greater number of lesions than did white light in the transverse
colon
, descending
colon
, and rectum.
CONCLUSION: Chromoendoscopy is superior to white light colonoscopy, autofluorescence imaging, and narrow-band imaging for detection of diminutive colorectal lesions in
adenomatous
polyposis.
[MeSH-major]
Adenomatous
Polyposis Coli / diagnosis. Colonoscopy / methods. Colorectal Neoplasms / diagnosis. Microscopy, Fluorescence / methods. Precancerous Conditions / diagnosis
[MeSH-minor]
Adenoma
/ diagnosis. Adolescent. Adult. Colonoscopes. Coloring Agents. Cross-Sectional Studies. Diagnosis, Differential. Female. Humans. Image Processing, Computer-Assisted. Male. Middle Aged
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(PMID = 19581862.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Coloring Agents
22.
Tzouvala M, Lazaris AC, Papatheodoridis GV, Kouvidou C, Papathomas TG, Kavantzas N, Elemenoglou I, Karamanolis DG, Agapitos E:
Potential role of apoptosis and apoptotic regulatory proteins in colorectal neoplasia: correlations with clinico-pathological parameters and survival.
Dig Dis Sci
; 2008 Feb;53(2):451-60
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Biopsies from 46 colorectal cancers, 121
adenomas
, and 25 controls were studied using monoclonal antibodies against p53, bcl-2, mdm2 and the terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL) method for apoptosis.
P53 and bcl2 protein expression was higher in
adenomas
>or=1 cm (P < 0.03) and tubulovillous-villous
adenomas
(P < 0.03), and correlated with dysplasia (P < 0.03).
In conclusion, both bcl-2 and p53 immunohistochemical profiles may be useful adjuncts in detecting
adenomas
with a malignant potential, whereas bcl-2 could be used in combination with Dukes' stage as a predictor of prognosis in colorectal cancer.
[MeSH-major]
Adenoma
/ metabolism. Apoptosis / physiology. Colorectal Neoplasms / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism
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(PMID = 17562177.001).
[ISSN]
0163-2116
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; EC 2.3.2.27 / MDM2 protein, human; EC 2.3.2.27 / Proto-Oncogene Proteins c-mdm2
23.
Yuri M, Sasahira T, Nakai K, Ishimaru S, Ohmori H, Kuniyasu H:
Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer.
Histopathology
; 2007 Oct;51(4):520-7
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[Title]
Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of
colonic
cancer.
AIMS: Two different pathways of linoleic acid (LA) metabolism have opposite effects on the development of
colonic
cancer: a protumoral prostaglandin cascade metabolized by cyclooxygenase (COX)-2, and an antitumoral peroxisome proliferator-activated receptor (PPAR)-gamma ligands metabolized by 15-lipooxygenase (LOX)-1.
The aim was to examine the switching of the two LA metabolic pathways in
colonic adenomas
and carcinomas.
MATERIALS AND METHODS: The expression of 15LOX-1 mRNA and COX-2 protein was examined in 54
adenomas
, 21 pTis carcinoma-in-
adenoma
lesions and 36 pT3/p Stage II carcinomas of the
colon
by in-situ hybridization and immunohistochemistry, respectively.
RESULTS: 15LOX-1 expression was found in 89% (48 of 54) of
adenomas
, 43% (nine of 21) of
adenomas
and 10% (two of 21) of carcinomas in carcinoma-in-
adenoma
lesions, but not in pT3 carcinomas (P < 0.0001).
In contrast, COX-2 production was found in 11% (six of 54) of
adenomas
, 52% (11 of 21) of
adenomas
and 71% (15 of 21) of carcinomas in carcinoma-in-
adenoma
lesions, and 92% (33 of 36) of pT3 carcinomas (P < 0.0001).
Concurrence of 15LOX-1 down-regulation and COX-2 up-regulation was found in 6% (three of 54) of
adenomas
, 33% (seven of 21) of
adenomas
and 71% (15 of 21) of carcinomas in carcinoma-in-
adenoma
lesions, and 92% (33 of 36) of pT3 carcinomas (P < 0.0001).
CONCLUSIONS: These results suggest that switching of LA metabolism by reversal of the expression of 15LOX-1 and COX-2 is associated with acquisition of malignant potential in
colonic
neoplasia.
[MeSH-major]
Adenoma
/ metabolism. Arachidonate 15-Lipoxygenase / metabolism. Carcinoma / metabolism.
Colonic
Neoplasms / metabolism. Cyclooxygenase 2 / metabolism
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(PMID = 17711445.001).
[ISSN]
0309-0167
[Journal-full-title]
Histopathology
[ISO-abbreviation]
Histopathology
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / RNA, Messenger; 9KJL21T0QJ / Linoleic Acid; EC 1.13.11.33 / Arachidonate 15-Lipoxygenase; EC 1.14.99.1 / Cyclooxygenase 2
24.
Grau MV, Sandler RS, McKeown-Eyssen G, Bresalier RS, Haile RW, Barry EL, Ahnen DJ, Gui J, Summers RW, Baron JA:
Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study.
J Natl Cancer Inst
; 2009 Feb 18;101(4):267-76
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[Title]
Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal
adenoma
risk: observational follow-up of a randomized study.
BACKGROUND: Frequent use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to reduce the risk of colorectal
adenomas
in randomized trials.
METHODS: We used data from the Aspirin/Folate
Polyp
Prevention Study (AFPPS), in which 1121 subjects were randomly assigned to receive placebo or aspirin (81 or 325 mg/d) for 3 years.
The primary outcomes were all
adenomas
and advanced lesions.
The protective effect of 81 mg of aspirin for colorectal
adenomas
persisted with continued posttreatment NSAID use.
The risk of any
adenoma
among frequent NSAID users was 26.8% vs 39.9% among placebo subjects who later used NSAIDs sporadically (adjusted relative risk = 0.62, 95% confidence interval [CI] = 0.39 to 0.98; P(trend) with NSAID use frequency = .03).
[MeSH-major]
Adenoma
/ prevention & control. Anti-Inflammatory Agents,
Non
-Steroidal / administration & dosage. Anticarcinogenic Agents / administration & dosage. Aspirin / administration & dosage. Colorectal Neoplasms / prevention & control
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]
(PMID = 19211442.001).
[ISSN]
1460-2105
[Journal-full-title]
Journal of the National Cancer Institute
[ISO-abbreviation]
J. Natl. Cancer Inst.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA 098286; United States / NCI NIH HHS / CA / P30 CA023108; United States / NCI NIH HHS / CA / CA 046927; United States / NCI NIH HHS / CA / U01 CA046927; United States / NCI NIH HHS / CA / R01 CA059005
[Publication-type]
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; R16CO5Y76E / Aspirin
[Other-IDs]
NLM/ PMC2644329
25.
Zhang X, Leav I, Revelo MP, Deka R, Medvedovic M, Jiang Z, Ho SM:
Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon.
PLoS Genet
; 2009 Jan;5(1):e1000334
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[Title]
Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in
the colon
.
Alpha-methylacyl-coenzyme A racemase (AMACR) regulates peroxisomal beta-oxidation of phytol-derived, branched-chain fatty acids from red meat and dairy products -- suspected risk factors for
colon
carcinoma (CCa).
By using a panel of immunostained-laser-capture-microdissected clinical samples comprising the entire
colon adenoma
-carcinoma sequence, we show that deregulation of AMACR during
colon
carcinogenesis involves two nonrandom events, resulting in the mutually exclusive existence of double-deletion at CG3 and CG10 and deletion of CG12-16 in a newly identified CpG island within the core promoter of AMACR.
It existed in histologically normal
colonic
glands and tubular
adenomas
with low AMACR expression and was absent in villous
adenomas
and all CCas expressing variable levels of AMACR.
Our findings identified key in vivo events and novel transcription factors responsible for AMACR regulation in CCas and suggested these AMACR deletions may have diagnostic/prognostic value for
colon
carcinogenesis.
[MeSH-major]
Colon
/ enzymology.
Colonic
Neoplasms / genetics. CpG Islands / genetics. Gene Expression Regulation, Neoplastic. Promoter Regions, Genetic. Racemases and Epimerases / genetics
[MeSH-minor]
Adenoma
, Villous / genetics.
Adenoma
, Villous / metabolism.
Adenoma
, Villous / pathology. Base Sequence. Binding Sites. Cell Differentiation. Cell Line, Tumor. Humans. Molecular Sequence Data. Polymorphism, Genetic. Repressor Proteins / metabolism. Sequence Deletion / genetics. Transcription, Genetic
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]
(PMID = 19148275.001).
[ISSN]
1553-7404
[Journal-full-title]
PLoS genetics
[ISO-abbreviation]
PLoS Genet.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA112532; United States / NCI NIH HHS / CA / R01 CA112532; United States / NIEHS NIH HHS / ES / P30 ES006096; United States / NCI NIH HHS / CA / R01 CA015776; United States / NCI NIH HHS / CA / CA015776; United States / NCI NIH HHS / CA / R01 CA062269; United States / NCI NIH HHS / CA / CA062269
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Repressor Proteins; 0 / ZNF202 protein, human; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
[Other-IDs]
NLM/ PMC2613032
26.
Wada R:
Proposal of a new hypothesis on the development of colorectal epithelial neoplasia: nonspecific inflammation--colorectal Paneth cell metaplasia--colorectal epithelial neoplasia.
Digestion
; 2009;79 Suppl 1:9-12
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Colorectal epithelial neoplasia (CR-
EN
), both
adenoma
and adenocarcinoma, may develop from the essential tubules of the colorectum.
In order to conclude the carcinogenesis of the colorectal cancer more clearly, the biological features including the genetic abnormality of the nonneoplastic mucosal epithelium
of colon
and rectum, which coexist in connection with CR-
EN
, should be investigated.
In this review, the importance of Paneth cell metaplasia of colorectum as one of the original mucosal regions of the development of CR-
EN
, and the new hypothesis on the development of CR-
EN
(nonspecific inflammation - colorectal Paneth cell metaplasia - colorectal epithelial neoplasia) are examined.
[MeSH-major]
Adenocarcinoma / pathology.
Adenoma
/ pathology. Colorectal Neoplasms / pathology. Paneth Cells / pathology
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[Copyright]
Copyright 2009 S. Karger AG, Basel.
(PMID = 19153484.001).
[ISSN]
1421-9867
[Journal-full-title]
Digestion
[ISO-abbreviation]
Digestion
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Switzerland
[Number-of-references]
19
27.
Tomita T:
Immunocytochemical localization of lymphatic and venous vessels in colonic polyps and adenomas.
Dig Dis Sci
; 2008 Jul;53(7):1880-5
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[Title]
Immunocytochemical localization of lymphatic and venous vessels in
colonic polyps
and
adenomas
.
Using lymphatic vessels endothelial hyaluronan receptor-1 (LYVE-1) immunocytochemical staining, hyperplastic
polyps
, tubular
adenomas
to villous
adenomas
, were investigated for lymphatic vessels compared with immunostained blood vessels using factor-8.
Four cases each of hyperplastic
polyps
, tubular
adenomas
to villous
adenomas
, were routinely fixed in formalin and embedded in paraffin and were immunostained using goat anti-LYVE-1 for lymphatic vessels and rabbit anti-factor-8 for blood vessels.
In normal
colon
and hyperplastic
polyps
, slender lymphatic vessels were noted in muscularis mucosa, which spread into the base of
colonic
crypt, whereas round venous vessels, they extend into lamina propria.
In tubular
adenomas
, small lymphatic and venous vessels were noted in broad fibrous stalks.
In villous
adenomas
, smaller lymphatic and venous vessels were noted in fine intervillous stroma.
In normal
colon
and hyperplastic
polyps
, slender, irregularly shaped lymphatic vessels were present in muscularis mucosa, spreading into the base of the
colonic
crypt.
In tubular
adenomas
, small lymphatic and venous vessels were noted in fibrous stalks.
In villous
adenomas
, smaller lymphatic and venous vessels were noted in intervillous stroma.
There are no increased lymphatic and venous vessels in intermucosal stroma and stalks of
adenomas
compared with normal
colon
.
[MeSH-major]
Adenoma
/ blood supply.
Colonic
Neoplasms / blood supply.
Colonic Polyps
. Immunohistochemistry / methods. Lymphatic Vessels. Veins
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Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / LYVE1 protein, human; 0 / Vesicular Transport Proteins
28.
Lansdorp-Vogelaar I, Kuntz KM, Knudsen AB, Wilschut JA, Zauber AG, van Ballegooijen M:
Stool DNA testing to screen for colorectal cancer in the Medicare population: a cost-effectiveness analysis.
Ann Intern Med
; 2010 Sep 21;153(6):368-77
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LIMITATION: No pathways other than the traditional
adenoma
-carcinoma sequence were modeled.
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diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers
.
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[ISSN]
1539-3704
[Journal-full-title]
Annals of internal medicine
[ISO-abbreviation]
Ann. Intern. Med.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / U01 CA115953; United States / NCI NIH HHS / CA / U01 CA097426; United States / NCI NIH HHS / CA / P30 CA008748; United States / PHS HHS / / HHSP233200700196P; United States / PHS HHS / / HHSP233200700350P; United States / NCI NIH HHS / CA / U01-CA-115953; United States / NCI NIH HHS / CA / U01-CA-088204; United States / PHS HHS / / HHSP233200700123P; United States / NCI NIH HHS / CA / U01 CA088204; United States / NCI NIH HHS / CA / U01-CA-097426
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Neoplasm
[Other-IDs]
NLM/ NIHMS438539; NLM/ PMC3578600
29.
Ashktorab H, Brim H, Al-Riyami M, Date A, Al-Mawaly K, Kashoub M, Al-Mjeni R, Smoot DT, Al-Moundhri M, Al-Hashemi S, Ganguly SS, Raeburn S:
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
Dig Dis Sci
; 2008 Oct;53(10):2723-31
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[Title]
Sporadic
colon
cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
We assessed
colonic
cancers in an attempt to identify tumors with DNA MMR deficiency and microsatellite instability (MSI).
Colon
cancer tissue was assayed using immunohistochemistry for expression of hMLH1 and hMSH2, and a panel of five pairs of microsatellite primers (NR21, NR22, NR24, BAT25, and BAT26) for MSI-H analysis and additional dinucleotide markers (D17S250, D5S346, and D2S123) used for MSI-L.
The methylation status of the p16 promoter was determined by methylation-
specific
polymerase chain reaction (PCR).
The information currently available indicates that there is an incidence of 4.7%
colon
cancer (49/1036) and 12.1% (126/1290)
colon adenoma
among the cases who underwent colonoscopy at these centers.
[MeSH-major]
Adenoma
/ genetics.
Colonic
Neoplasms / genetics. Colorectal Neoplasms / genetics. DNA Mismatch Repair. Microsatellite Instability
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[Cites]
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(PMID = 18299982.001).
[ISSN]
0163-2116
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA102681
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Mucins; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutL Protein Homolog 1; EC 3.6.1.3 / MutS Homolog 2 Protein
30.
Fujimoto T, Yoshimatsu K, Watanabe K, Yokomizo H, Otani T, Matsumoto A, Osawa G, Onda M, Ogawa K:
Overexpression of human X-box binding protein 1 (XBP-1) in colorectal adenomas and adenocarcinomas.
Anticancer Res
; 2007 Jan-Feb;27(1A):127-31
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[Title]
Overexpression of human X-box binding protein 1 (XBP-1) in colorectal
adenomas
and adenocarcinomas.
Recently, overexpression of XBP-1 has been reported in breast cancer including
non
-invasive carcinomas, and was suggested to play an important role in breast carcinogenesis.
To investigate the involvement of XBP-1 in colorectal tumorigenecity, the expression of XBP-1 was examined in four
colon
cancer cell lines, six colorectal
polyps
and five colorectal carcinomas.
MATERIALS AND METHODS: The study population consisted of eleven patients who had undergone resection for colorectal cancer or
adenoma
from 2000 to 2002.
Four
colon
cancer cell lines, DLD1, SW480, HCT15 and WiDr, were also analyzed for expression of XBP-1.
Reverse transcription-polymerase chain reaction was performed using eleven primary
colon
tumors.
RESULTS: The XBP-1 gene was overexpressed in four cases out of five primary colorectal carcinomas and in four cases out of six colorectal
adenomas
.
Immunohistochemical staining demonstrated that XBP-1 protein was strongly stained in the cytoplasms of cancer cells, whereas it was unreactive in the normal
colon
epithelial cells and stromal cells.
CONCLUSION: These data indicate that increased expression of XBP-1 gene may play some role in human
colon
carcinogenesis through impairment of cell differentiation regulation.
[MeSH-major]
Adenocarcinoma / metabolism.
Adenoma
/ metabolism. Colorectal Neoplasms / metabolism. DNA-Binding Proteins / biosynthesis. Nuclear Proteins / biosynthesis
MedlinePlus Health Information.
consumer health - Colorectal Cancer
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 17352224.001).
[ISSN]
0250-7005
[Journal-full-title]
Anticancer research
[ISO-abbreviation]
Anticancer Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Transcription Factors; 0 / regulatory factor X transcription factors
31.
Nusko G, Hahn EG, Mansmann U:
Characteristics of metachronous colorectal adenomas found during long-term follow-up: analysis of four subsequent generations of adenoma recurrence.
Scand J Gastroenterol
; 2009;44(6):736-44
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[Title]
Characteristics of metachronous colorectal
adenomas
found during long-term follow-up: analysis of four subsequent generations
of adenoma
recurrence.
OBJECTIVE: Because of the high recurrence rates of colorectal
adenomas
, regular surveillance by colonoscopy has been recommended, but there is still a dearth of information on the long-term results of follow-up colonoscopy after polypectomy.
The aims of this study were to determine the differences between initial
adenomas
and metachronous lesions, to evaluate the effect of long-term surveillance and to describe the hypothetical origin of the colorectal
adenoma
-carcinoma sequence.
MATERIAL AND METHODS: Between 1978 and 2003 a total of 1091 patients undergoing periodic surveillance examinations were prospectively documented at the Erlangen Registry of Colorectal
Polyps
.
Statistical analysis using chi(2) testing
of adenoma
characteristics found in four subsequent recurrence periods was carried out, and the relative risk (RR) for the development of metachronous
adenomas
of advanced pathology was calculated.
RESULTS: In comparison with the initial findings, metachronous
adenomas
are generally significantly smaller lesions (p<0.00001), usually tubular in shape (p<0.00001) and bearing high-grade dysplasia less often (p<0.00001) and are usually located in the right
colon
(p<0.00001).
These differences are found between the initial and four subsequent generations of metachronous
adenomas
.
The number of synchronous
adenomas
is reduced only in the first recurrence (p<0.001); in the further generations equal proportions of multiplicity are found, as in the baseline examination.
Patients with
adenomas
of advanced pathology, i.e. large, tubulovillous or villous
adenomas
at baseline, have a significantly higher risk for large (RR 2.73; 95% CI 1.77-4.20), tubulovillous or villous (RR 1.55; 95% CI 1.06-2.25) or multiple (RR 2.45; 95% CI 1.83-3.29) metachronous
adenomas
at the first recurrence.
CONCLUSIONS: Metachronous
adenomas
show the uniform characteristics of being small tubular lesions rarely bearing high-grade dysplasia, usually located in the right
colon
.
[MeSH-major]
Adenoma
/ pathology. Colorectal Neoplasms / pathology. Neoplasms, Second Primary
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.
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(PMID = 19277927.001).
[ISSN]
1502-7708
[Journal-full-title]
Scandinavian journal of gastroenterology
[ISO-abbreviation]
Scand. J. Gastroenterol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Norway
32.
Landau D, Garrett C, Chodkiewicz C:
A case of primary squamous cell colon cancer.
J Oncol Pharm Pract
; 2007 Mar;13(1):47-8
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[Title]
A case of primary squamous cell
colon
cancer.
Carcinomas of the
colon
are a common cancer seen in both inpatient and outpatient settings with approximately 145,000 new cases being diagnosed every year in the USA.
Despite the frequency of these cancers being seen, it continues to be a rarity to see a primary squamous cell cancer of the
colon
.
While the exact aetiology of this rare tumour is currently still not completely understood, various aetiologies include chronic irritation leading to squamous differentiation, embryonic migration of ectodermal cells to
the colon
, or
adenomas
undergoing squamous transformation.
[MeSH-major]
Carcinoma, Squamous Cell / pathology.
Colonic
Neoplasms / pathology
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(PMID = 17621567.001).
[ISSN]
1078-1552
[Journal-full-title]
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
[ISO-abbreviation]
J Oncol Pharm Pract
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
33.
Crispin A, Birkner B, Munte A, Nusko G, Mansmann U:
Process quality and incidence of acute complications in a series of more than 230,000 outpatient colonoscopies.
Endoscopy
; 2009 Dec;41(12):1018-25
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RESULTS:
Colon
preparation resulted in clear bowels in 76.31 % of patients, liquid residues in 22.22 %, and dirty bowels in 1.47 %.
[MeSH-minor]
Acute Disease.
Adenoma
/ diagnosis. Aged.
Colon
/ injuries.
Colonic
Neoplasms / diagnosis.
Colonic Polyps
/ surgery. Female. Heart Diseases / etiology. Hemorrhage / etiology. Humans. Intestinal Perforation / etiology. Male. Middle Aged. Respiration Disorders / etiology. Risk Factors
MedlinePlus Health Information.
consumer health - Colonoscopy
.
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[Copyright]
Georg Thieme Verlag KG Stuttgart New York.
(PMID = 19856246.001).
[ISSN]
1438-8812
[Journal-full-title]
Endoscopy
[ISO-abbreviation]
Endoscopy
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
34.
Fadare O, Parkash V, Fiedler PN, Mayerson AB, Asiyanbola B:
Tumor-to-tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma.
Pathol Int
; 2005 Sep;55(9):574-9
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[Title]
Tumor-to-tumor metastasis to a thyroid follicular
adenoma
as the initial presentation of a
colonic
adenocarcinoma.
Herein is described the case of a 59-year-old woman whose thyroid nodule (a follicular
adenoma
) was resected and found to contain foci of a well-differentiated adenocarcinoma with a morphologic and immunohistochemical profile consistent with origination from the lower gastrointestinal tract.
Subsequent diagnostic work-up revealed a sigmoid
colon
tumor with metastases to the liver.
This is, to the authors' knowledge, the first reported example of a
colon
adenocarcinoma whose initial clinical manifestation was a metastasis to a thyroid neoplasm and only the third reported example of a
colonic
adenocarcinoma metastatic to a thyroid tumor.
[MeSH-major]
Adenocarcinoma / secondary.
Adenoma
/ pathology.
Colonic
Neoplasms / pathology. Thyroid Neoplasms / secondary
MedlinePlus Health Information.
consumer health - Thyroid Cancer
.
COS Scholar Universe.
author profiles
.
The Weizmann Institute of Science GeneCards and MalaCards databases.
gene/protein/disease-specific - MalaCards for follicular adenoma
.
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(PMID = 16143033.001).
[ISSN]
1320-5463
[Journal-full-title]
Pathology international
[ISO-abbreviation]
Pathol. Int.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
Australia
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
[Number-of-references]
23
35.
Schulz AC, Bojarski C, Buhr HJ, Kroesen AJ:
Occurrence of adenomas in the pouch and small intestine of FAP patients after proctocolectomy with ileoanal pouch construction.
Int J Colorectal Dis
; 2008 Apr;23(4):437-41
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[Title]
Occurrence of
adenomas
in the pouch and small intestine of FAP patients after proctocolectomy with ileoanal pouch construction.
PURPOSE: Proctocolectomy with ileoanal pouch construction is the standard therapy for patients with familial
adenomatous
polyposis coli (FAP) to prevent the genesis of colorectal carcinomas.
In our patient population, we observed the postoperative development of
adenomas
not only in the pouch but also in the remaining small intestine.
The exact incidence of these ileal
polyps
is still unknown, since the diagnostic possibilities of examining the small intestine are limited.
METHODS: We performed wireless capsule endoscopy (CE) in patients who developed postoperative pouch
adenomas
(PA) to record the simultaneous occurrence of small bowel
adenomas
and PA.
Eight PA patients (all with PA) also had
adenomas
in the small intestine diagnosed by CE.
CONCLUSIONS: Since jejunal and ileal
adenomas
occur in all patients with PA, we recommend regular follow-up examinations, which include pouch endoscopy at 3 months and annually after surgery in the presence of PA after proctocolectomy and pouch creation.
[MeSH-major]
Adenoma
/ epidemiology.
Adenomatous
Polyposis Coli / surgery.
Colonic
Pouches / adverse effects. Intestine, Small / pathology. Proctocolectomy, Restorative / adverse effects
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[Cites]
Dis Colon Rectum. 2005 Apr;48(4):816-23
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Surgery. 2004 Oct;136(4):795-803
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15467664.001
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(PMID = 18193239.001).
[ISSN]
0179-1958
[Journal-full-title]
International journal of colorectal disease
[ISO-abbreviation]
Int J Colorectal Dis
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Germany
36.
Waye JD:
Improving lesion detection during colonoscopy.
Gastroenterol Hepatol (N Y)
; 2010 Oct;6(10):647-52
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Colonoscopy has changed since it was first introduced 50 years ago, with glass fibers being replaced by video electronics, the addition of water jets, better illumination, and the use of filters to enhance visual identification of
polyps
.
In spite of these improvements,
polyps
and tumors of the
colon
are still overlooked even by the most meticulous examiner.
The Third Eye Retroscope is a device that, in conjunction with the video colonoscope, may be able to find virtually all lesions in
the colon
.
This novel device is described here and presents a new way to look into
the colon
.
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(PMID = 21103444.001).
[ISSN]
1554-7914
[Journal-full-title]
Gastroenterology & hepatology
[ISO-abbreviation]
Gastroenterol Hepatol (N Y)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2978415
[Keywords]
NOTNLM ; Retroscope / Third Eye Retroscope / adenoma / colonoscopy / polyps / retroversion / screening / surveillance
37.
Hornick JL, Farraye FA, Odze RD:
Clinicopathologic and immunohistochemical study of small apparently "de novo" colorectal adenocarcinomas.
Am J Surg Pathol
; 2007 Feb;31(2):207-15
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[Title]
Clinicopathologic and immunohistochemical study of small apparently "
de
novo" colorectal adenocarcinomas.
Rarely, adenocarcinomas of the colorectum develop as small (< or =1.0 cm) rapidly invasive tumors without an obvious
adenomatous
or "in situ" component.
These tumors have been termed "
de
novo" carcinomas.
The aim of this study was to evaluate and compare the pathologic features, biologic characteristics, and natural history of small apparently
de
novo invasive colorectal adenocarcinomas with conventional large (>1.0 cm) carcinomas.
Routinely processed specimens from 20 patients (M/F ratio: 13/7; mean age: 65 y) with small apparently
de
novo invasive colorectal adenocarcinomas (all < or =1.0 cm in size) were evaluated for a variety of clinical and pathologic features.
Small apparently
de
novo invasive adenocarcinomas were present in the left
colon
, transverse
colon
, and right
colon
in 85%, 10%, and 5% of cases, respectively.
Upon complete sectioning of the tissue blocks of tumor, residual foci of
adenomatous
epithelium were present in 16/20 (80%) cases, of which 75% contained foci of high-grade dysplasia.
In our patient population, true small
de
novo colorectal adenocarcinomas, tumors that lack an identifiable
adenomatous
component, are exceedingly rare, because complete tissue sectioning reveals residual
adenomatous
tissue in the majority of cases.
The biologic characteristics and natural history of small carcinomas with a minimal dysplastic component, and those with no identifiable
adenomatous
component, are similar to conventional large (>1 cm) adenocarcinomas, and, thus, they should probably be treated similarly.
[MeSH-major]
Adenocarcinoma / pathology.
Adenoma
/ pathology. Colorectal Neoplasms / pathology
MedlinePlus Health Information.
consumer health - Colorectal Cancer
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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(PMID = 17255765.001).
[ISSN]
0147-5185
[Journal-full-title]
The American journal of surgical pathology
[ISO-abbreviation]
Am. J. Surg. Pathol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
38.
Phelps RA, Broadbent TJ, Stafforini DM, Jones DA:
New perspectives on APC control of cell fate and proliferation in colorectal cancer.
Cell Cycle
; 2009 Aug 15;8(16):2549-56
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Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor
adenomatous
polyposis coli (APC) is thought to initiate
colon adenoma
formation.
However, examination of tumors from familial
adenomatous
polyposis coli (FAP) patients has failed to confirm the presence of nuclear beta-catenin in early lesions following APC loss despite robust staining in later lesions.
This observation presents the possibility that
colon
adenomas
arise through a beta-catenin-independent function of APC.
Though there are currently contrasting models to explain
colon
tumorigenesis, our goal is to begin to reconcile data from multiple different model systems and provide a functional view into the initiation and progression
of colon
cancer.
[MeSH-major]
Adenomatous
Polyposis Coli / pathology. Cell Differentiation / physiology. Colorectal Neoplasms / pathology
Genetic Alliance.
consumer health - Colorectal Cancer
.
MedlinePlus Health Information.
consumer health - Colorectal Cancer
.
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(PMID = 19597346.001).
[ISSN]
1551-4005
[Journal-full-title]
Cell cycle (Georgetown, Tex.)
[ISO-abbreviation]
Cell Cycle
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
94
39.
Khatibzadeh N, Ziaee SA, Rahbar N, Molanie S, Arefian L, Fanaie SA:
The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps.
J Cancer Res Ther
; 2005 Oct-Dec;1(4):204-7
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[Title]
The indirect role of site distribution in high-grade dysplasia in
adenomatous
colorectal
polyps
.
BACKGROUND: The appropriate application of Endoscopic modalities for polypectomy depends on the likelihood that
the adenoma
in question harbors invasive cancer.
While prior studies have evaluated
polyp
size and morphology in assessing the risk of malignancy, in recent decay some authorities have paid more attention to dysplasia.
All in all, the relative risk of cancer based on
polyp
distribution in correlation with dysplasia has not been statistically studied which is done in our study.
METHODS AND MATERIALS: Between June 2001 and March 2004, the distribution of 130
adenomatous polyps
was compared with synchronous invasive or in situ cancer.
Factors such as Patient age, Patients gender, location of lesion, size of
polyp
, histological subtype
of adenoma
on biopsy, degree of dysplasia, synchronous cancer,
color
of
polyp
, and number of
polyps
were included in the data collection.
CONCLUSION: Lesions greater than 1 cm in diameter with high-grade dysplasia after splenic flexure should be managed as presumptive malignancies with segmental
colon
resection.
[MeSH-major]
Adenomatous Polyps
/ pathology. Colorectal Neoplasms / pathology
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(PMID = 17998654.001).
[ISSN]
1998-4138
[Journal-full-title]
Journal of cancer research and therapeutics
[ISO-abbreviation]
J Cancer Res Ther
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
India
40.
Burkart AL, Sheridan T, Lewin M, Fenton H, Ali NJ, Montgomery E:
Do sporadic Peutz-Jeghers polyps exist? Experience of a large teaching hospital.
Am J Surg Pathol
; 2007 Aug;31(8):1209-14
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[Title]
Do sporadic Peutz-Jeghers
polyps
exist? Experience of a large teaching hospital.
Most types of sporadic gastrointestinal (GI)
polyps
vastly outnumber their syndromic counterparts.
In contrast, the incidence of sporadic Peutz-Jeghers
polyps
(PJP) is unknown.
The pathology database of a large hospital was searched for "Peutz-Jeghers
polyp
(s)," yielding 121
polyps
from 38 patients.
The
polyps
were reviewed by 3 pathologists to confirm the diagnosis.
Of the 102
polyps
included after histologic review, 94
polyps
arose in patients meeting the World Health Organization criteria for PJS.
These PJS
polyps
were eliminated from further analysis.
Of the 8 potential sporadic PJP, only 3
polyps
from 3 patients had unequivocal PJP histologic features, all from the small intestine.
The 5 remaining patients each had a
colonic polyp
with features suggestive, but not definitely diagnostic of, PJP.
One patient had a history of high-grade dysplasia in a tubulovillous
adenoma
in
the colon
at 53 years, but no family cancer history.
Another had a history of pituitary
adenoma
at age 39, and the last had ductal breast carcinoma diagnosed 4 years before the discovery of the
polyp
.
[MeSH-major]
Hospitals, Teaching. Intestinal
Polyps
/ pathology. Peutz-Jeghers Syndrome / pathology
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(PMID = 17667545.001).
[ISSN]
0147-5185
[Journal-full-title]
The American journal of surgical pathology
[ISO-abbreviation]
Am. J. Surg. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
41.
Lee EJ, Park CK, Kim JW, Chang DK, Kim KM:
Deletion mutation of BRAF in a serrated adenoma from a patient with familial adenomatous polyposis.
APMIS
; 2007 Aug;115(8):982-6
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[Title]
Deletion mutation of BRAF in a serrated
adenoma
from a patient with familial
adenomatous
polyposis.
BRAF gene mutations in the colorectum have been associated with serrated
adenomas
and less frequently with hyperplastic
polyps
, villous
adenomas
, tubular
adenomas
, and carcinomas.
Most BRAF mutations in
the colon
have been reported as a V600E substitution.
We report a case with a very rare deletion mutation of BRAF (c.1799-1801delTGA, p.Val600_Lys601delinsGlu) in a serrated
adenoma
; the patient has familial
adenomatous
polyposis with a germline mutation of the APC gene (c.3578delA, p.Gln1193ArgfsX1264).
Genetic studies on fundic gland
polyps
and tubular
adenomas
from the same patient failed to demonstrate BRAF mutation.
This case is the first reported with a deletion mutation of BRAF found in
the colon
.
[MeSH-major]
Adenomatous
Polyposis Coli / genetics. Gene Deletion. Proto-Oncogene Proteins B-raf / genetics
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(PMID = 17696956.001).
[ISSN]
0903-4641
[Journal-full-title]
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
[ISO-abbreviation]
APMIS
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Denmark
[Chemical-registry-number]
EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
42.
Douma KF, Aaronson NK, Vasen HF, Bleiker EM:
Psychosocial issues in genetic testing for familial adenomatous polyposis: a review of the literature.
Psychooncology
; 2008 Aug;17(8):737-45
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[Title]
Psychosocial issues in genetic testing for familial
adenomatous
polyposis: a review of the literature.
OBJECTIVES: Familial
adenomatous
polyposis (FAP) is characterized by the development of multiple
adenomas
in
the colon
that can lead to colorectal cancer.
[MeSH-major]
Adenomatous Polyps
/ genetics.
Adenomatous Polyps
/ psychology.
Colonic
Neoplasms / genetics.
Colonic
Neoplasms / psychology. Genetic Techniques / instrumentation
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(PMID = 18613296.001).
[ISSN]
1099-1611
[Journal-full-title]
Psycho-oncology
[ISO-abbreviation]
Psychooncology
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
England
[Number-of-references]
33
43.
Shelton DN, Sandoval IT, Eisinger A, Chidester S, Ratnayake A, Ireland CM, Jones DA:
Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development.
Cancer Res
; 2006 Aug 1;66(15):7571-7
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[Title]
Up-regulation of CYP26A1 in
adenomatous
polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and
colon
tumor development.
Mutations in the
adenomatous
polyposis coli (APC) tumor suppressor gene seem to underlie the initiation of many colorectal carcinomas.
Paradoxically, however, previous studies found that dietary supplementation of Apc(MIN) mice with retinoic acid failed to abrogate
adenoma
formation.
While investigating the above finding, we found that expression of CYP26A1, a major retinoic acid catabolic enzyme, was up-regulated in Apc(MIN) mouse
adenomas
, human FAP
adenomas
, human sporadic
colon
carcinomas, and in the intestine of apc(mcr) mutant zebrafish embryos.
[MeSH-major]
Adenomatous
Polyposis Coli Protein / deficiency.
Colonic
Neoplasms / metabolism. Cytochrome P-450 Enzyme System / biosynthesis. Intestines / pathology. Wnt Proteins / metabolism
Genetic Alliance.
consumer health - Familial Adenomatous Polyposis (FAP)
.
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(subscription/membership/fee required).
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.
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Cited by Patents in
.
ZFIN.
ZFIN
.
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(PMID = 16885356.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Adenomatous Polyposis Coli Protein; 0 / Cytochrome P-450 Enzyme Inhibitors; 0 / Morpholines; 0 / Oligonucleotides; 0 / Wnt Proteins; 5688UTC01R / Tretinoin; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.14.1 / retinoic acid 4-hydroxylase
44.
Obtulowicz T, Swoboda M, Speina E, Gackowski D, Rozalski R, Siomek A, Janik J, Janowska B, Ciesla JM, Jawien A, Banaszkiewicz Z, Guz J, Dziaman T, Szpila A, Olinski R, Tudek B:
Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients.
Mutagenesis
; 2010 Sep;25(5):463-71
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[Title]
Oxidative stress and 8-oxoguanine repair are enhanced in
colon adenoma
and carcinoma patients.
Oxidative stress is involved in the pathogenesis
of colon
cancer.
In the examined groups of patients with colorectal cancer (CRC, n = 89), benign
adenoma
(
AD
, n = 77) and healthy volunteers (controls, n = 99), we measured: vitamins A, C and E in blood plasma, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanine (8-oxoGua) in leukocytes and urine, leukocyte 8-oxoGua excision activity, mRNA levels of APE1, OGG1, 8-oxo-7,8-dihydrodeoxyguanosine 5'-triphosphate pyrophosphohydrolase (MTH1) and OGG1 polymorphism.
The vitamin levels decreased gradually in
AD
and CRC patients.
8-OxodG increased in leukocytes and urine of CRC and
AD
patients.
8-OxoGua excision was higher in CRC patients than in controls, in spite of higher frequency of the OGG1 Cys326Cys genotype, encoding a glycosylase with decreased activity. mRNA levels of OGG1 and APE1 increased in CRC and
AD
patients, which could explain increased 8-oxoGua excision rate in CRC patients.
The results suggest that oxidative stress occurs in CRC and
AD
individuals.
[MeSH-major]
Adenoma
/ metabolism. Carcinoma / metabolism.
Colonic
Neoplasms / metabolism. DNA Repair / genetics. Deoxyguanosine / analogs & derivatives. Oxidative Stress / genetics
[MeSH-minor]
Adenomatous Polyps
/ blood.
Adenomatous Polyps
/ metabolism. Adult. Aged. Aging / genetics. Antioxidants / metabolism. Case-Control Studies. DNA Glycosylases / genetics. DNA Glycosylases / metabolism. DNA Repair Enzymes / genetics. DNA Repair Enzymes / metabolism. DNA, Neoplasm / metabolism. DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics. DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Neoplasm Staging. Phosphoric Monoester Hydrolases / genetics. Phosphoric Monoester Hydrolases / metabolism. Polymorphism, Single Nucleotide / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Sex Characteristics. Smoking / adverse effects. Smoking / genetics
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(PMID = 20534734.001).
[ISSN]
1464-3804
[Journal-full-title]
Mutagenesis
[ISO-abbreviation]
Mutagenesis
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antioxidants; 0 / DNA, Neoplasm; 0 / RNA, Messenger; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.6.- / 8-oxodGTPase; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human; EC 4.2.99.18 / APEX1 protein, human; EC 4.2.99.18 / DNA-(Apurinic or Apyrimidinic Site) Lyase; EC 6.5.1.- / DNA Repair Enzymes; G9481N71RO / Deoxyguanosine
45.
Miyoshi N, Ohue M, Noura S, Yano M, Sasaki Y, Kishi K, Yamada T, Miyashiro I, Ohigashi H, Iishi H, Ishikawa O, Imaoka S:
Surgical usefulness of indocyanine green as an alternative to India ink for endoscopic marking.
Surg Endosc
; 2009 Feb;23(2):347-51
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BACKGROUND: India ink has been commonly used for preoperative
colonic
tattooing, but various complications have been reported.
[MeSH-major]
Adenoma
/ surgery. Carcinoma / surgery. Colonoscopy. Colorectal Neoplasms / surgery. Coloring Agents. Indocyanine Green
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(PMID = 18443867.001).
[ISSN]
1432-2218
[Journal-full-title]
Surgical endoscopy
[ISO-abbreviation]
Surg Endosc
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Coloring Agents; IX6J1063HV / Indocyanine Green
46.
Ahlawat S, Al-Kawas FH:
Invagination of the muscularis propria in a polyp stalk: a rare cause of post-polypectomy perforation of the colon.
Endoscopy
; 2007 Feb;39 Suppl 1:E78-9
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[Title]
Invagination of the muscularis propria in a
polyp
stalk: a rare cause of post-polypectomy perforation of the
colon
.
[MeSH-major]
Adenoma
, Villous / surgery.
Colonic
Diseases / etiology.
Colonic Polyps
/ surgery. Colonoscopy. Intestinal Mucosa. Intestinal Perforation / etiology. Intussusception / complications. Postoperative Complications / etiology
MedlinePlus Health Information.
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.
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(PMID = 17440881.001).
[ISSN]
1438-8812
[Journal-full-title]
Endoscopy
[ISO-abbreviation]
Endoscopy
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Germany
47.
Weng SW, Liu JW, Chen WJ, Wang PW:
Recurrent Klebsiella pneumoniae liver abscess in a diabetic patient followed by Streptococcus bovis endocarditis--occult colon tumor plays an important role.
Jpn J Infect Dis
; 2005 Apr;58(2):70-2
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[Title]
Recurrent Klebsiella pneumoniae liver abscess in a diabetic patient followed by Streptococcus bovis endocarditis--occult
colon
tumor plays an important role.
The patient later developed Streptococcus bovis bacteremia originating from a
colon
tumor with complications of endocarditis, osteomyelitis, and silent splenic abscess.
Occult
colon
tumor may have played an important role in our case, with recurrent infection arising from colonizers of the gastrointestinal tract.
As our case shows, the possible association between occult
colon
tumor and K. pneumoniae liver abscess in diabetic patients should be surveyed.
[MeSH-major]
Colonic
Neoplasms / complications. Endocarditis, Bacterial / microbiology. Klebsiella Infections / etiology. Liver Abscess / microbiology. Streptococcal Infections / etiology
[MeSH-minor]
Adenoma
, Villous / complications. Aged. Anti-Bacterial Agents / therapeutic use. Diabetes Mellitus, Type 2 / complications. Humans. Klebsiella pneumoniae / isolation & purification. Male. Streptococcus bovis / isolation & purification
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(PMID = 15858282.001).
[ISSN]
1344-6304
[Journal-full-title]
Japanese journal of infectious diseases
[ISO-abbreviation]
Jpn. J. Infect. Dis.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Anti-Bacterial Agents
48.
García Sánchez Mdel V, González R, Iglesias Flores E, Gómez Camacho F, Casais Juanena L, Cerezo Ruiz A, Montero Pérez-Barquero M, Muntané J, de Dios Vega JF:
[Diagnostic value of fecal calprotectin in predicting an abnormal colonoscopy].
Med Clin (Barc)
; 2006 Jun 10;127(2):41-6
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[Transliterated title]
Precisión diagnóstica
de
la calprotectina fecal para predecir una colonoscopia patológica.
The colonoscopy is the gold standard method of detecting an organic pathology in
the colon
.
Fecal calprotectin (FCP) is a marker that may detect organic pathologies of the
colon
.
People were divided in: normal colonoscopy: 117 people, and 28
colon
adenomas
, 20 colorectal cancer (CRC) and 25 IBD.
217 mg/kg was the best cut-off for discriminating patients with organic
colon
disorders.
The measurement of FCP is a
non
-invasive, inexpensive, reliable and easily measured test.
[MeSH-major]
Colonic
Diseases / diagnosis.
Colonic
Neoplasms / diagnosis. Colonoscopy. Feces / chemistry. Inflammatory Bowel Diseases / diagnosis. Leukocyte L1 Antigen Complex / analysis
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.
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(PMID = 16801001.001).
[ISSN]
0025-7753
[Journal-full-title]
Medicina clínica
[ISO-abbreviation]
Med Clin (Barc)
[Language]
spa
[Publication-type]
Clinical Trial; English Abstract; Journal Article
[Publication-country]
Spain
[Chemical-registry-number]
0 / Leukocyte L1 Antigen Complex
49.
Togashi K, Shimura K, Konishi F, Miyakura Y, Koinuma K, Horie H, Yasuda Y:
Prospective observation of small adenomas in patients after colorectal cancer surgery through magnification chromocolonoscopy.
Dis Colon Rectum
; 2008 Feb;51(2):196-201
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[Title]
Prospective observation of small
adenomas
in patients after colorectal cancer surgery through magnification chromocolonoscopy.
PURPOSE: This study was designed to confirm the safety of not removing small
adenoma
in patients who undergo colorectal cancer surgery.
Benign
adenomas
of 6 mm or less in size, diagnosed based on both nonmagnified and magnified observation, were left unresected with a maximum of three
polyps
per patient.
The sites of the
polyps
were marked by tattooing.
In follow-up,
polyps
were removed if they grew larger than 6 mm, were suspicious for high-grade dysplasia, or the patients requested to have
polyps
removal.
RESULTS: Five hundred
polyps
in 284 patients met the above criteria and were not resected, and 412
polyps
were followed by repeat colonoscopy.
At the final colonoscopy, 71 percent of 412
polyps
showed no change in size, 15 percent increased, 3 percent decreased, and 11 percent could not be identified.
Eighty-eight
polyps
were resected endoscopically, and histology showed neither cancer nor
adenomas
with high-grade dysplasia.
Two hundred fifty-five
polyps
detected in the same patient cohort during index/repeat colonoscopy were removed, including four
adenomas
with high-grade dysplasia and two T1 cancers.
CONCLUSIONS: Leaving small
polyps
is safe even in patients who have undergone colorectal cancer surgery, provided that careful observation is guaranteed.
[MeSH-major]
Adenoma
/ diagnosis.
Colonic Polyps
/ surgery. Colonoscopy / methods. Digestive System Surgical Procedures / methods. Neoplasms, Second Primary / diagnosis. Postoperative Care / methods
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(PMID = 18176829.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
50.
Yuan B, Jin X, Zhu R, Zhang X, Liu J, Wan H, Lu H, Shen Y, Wang F:
Cronkhite-Canada syndrome associated with rib fractures: a case report.
BMC Gastroenterol
; 2010;10:121
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Esophagogastroduodenoscopy, video capsule endoscopy and colonoscopy revealed various sizes of generalized gastrointestinal
polyps
.
Histological examination of the biopsy specimens obtained from the stomach and
the colon
showed
adenomatous polyp
and inflammatory
polyp
respectively.
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[Cites]
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Digestion. 2004;69(1):57-62
[
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]
(PMID = 20955587.001).
[ISSN]
1471-230X
[Journal-full-title]
BMC gastroenterology
[ISO-abbreviation]
BMC Gastroenterol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2972238
51.
Lefevre JH, Colas C, Coulet F, Bonilla C, Mourra N, Flejou JF, Tiret E, Bodmer W, Soubrier F, Parc Y:
MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.
Fam Cancer
; 2010 Dec;9(4):589-94
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MYH associated polyposis is a hereditary syndrome responsible for early colorectal cancer with a distinct genetic pathway from the Familial
Adenomatous
Polyposis or the Hereditary
Non
Polyposis Colorectal Cancer syndrome.
One patient who developed
colon
cancer had loss of expression of MLH1 on tumoral tissue and microsatellite instability (MSI) phenotype.
[MeSH-major]
Adaptor Proteins, Signal Transducing / genetics.
Adenoma
/ genetics.
Adenomatous
Polyposis Coli / genetics. Colorectal Neoplasms / genetics. DNA Glycosylases / genetics. Genes, APC. Mutation / genetics. Nuclear Proteins / genetics
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[Cites]
Am J Hum Genet. 2003 Jan;72(1):88-100
[
12474140.001
]
[Cites]
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]
(PMID = 20640893.001).
[ISSN]
1573-7292
[Journal-full-title]
Familial cancer
[ISO-abbreviation]
Fam. Cancer
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / DNA, Neoplasm; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase; EC 3.6.1.3 / MutL Protein Homolog 1
52.
Javeri K, Williams TR, Bonnett JW:
An overview of the method, application, and various findings of computed tomographic colonography in patients after incomplete colonoscopy.
Curr Probl Diagn Radiol
; 2010 Nov-Dec;39(6):262-74
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Colon
cancer is the third most common malignancy in the USA with 154,000 new cases and 52,000 deaths in 2007.
Routine CT colonography imaging of the insufflated
colon
was performed in both the supine and the prone positions with oral contrast.
Each patient was classified into groups based on the quality/adequacy of the examination, presence, number, and size of
polyps
.
[MeSH-major]
Colonic
Neoplasms / radiography. Colonography, Computed Tomographic. Colonoscopy
[MeSH-minor]
Adenocarcinoma / radiography.
Adenoma
/ radiography. Colitis / radiography.
Colonic Polyps
/ pathology.
Colonic Polyps
/ surgery. Humans. Hyperplasia. Image Processing, Computer-Assisted. Lipoma / radiography. Patient Acceptance of Health Care
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[Copyright]
Copyright © 2010 Mosby, Inc. All rights reserved.
(PMID = 20875613.001).
[ISSN]
1535-6302
[Journal-full-title]
Current problems in diagnostic radiology
[ISO-abbreviation]
Curr Probl Diagn Radiol
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
53.
He JJ:
[Meta analysis of 2025 cases with multiple primary colorectal carcinoma].
Zhonghua Wei Chang Wai Ke Za Zhi
; 2006 May;9(3):225-9
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30.9% of the lesions were located in the rectum, 19.9% in the sigmoid, 9.0% in the descending
colon
, 5.2% the in splenic flexure, 9.1% in the transverse
colon
, 6.1% in the hepatic flexure, 11.8% in the ascending
colon
,and 8.1% in the caecum.
37.6% of the cases were complicated with extra- intestinal lesions,and 43.7%
adenoma
or
polyps
.
Histological type was the same in 60.6% of the cases,and adenocarcinoma accounted for 89.2% and cancerization
of adenoma
8.4%.
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(PMID = 16721683.001).
[ISSN]
1671-0274
[Journal-full-title]
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
[ISO-abbreviation]
Zhonghua Wei Chang Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Meta-Analysis
[Publication-country]
China
54.
Chakravarti B, Dwivedi SK, Mithal A, Chattopadhyay N:
Calcium-sensing receptor in cancer: good cop or bad cop?
Endocrine
; 2009 Jun;35(3):271-84
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One situation is loss of CaR expression, resulting in loss of growth suppressing effects of elevated extracellular Ca(2+) by CaR, reported in parathyroid
adenoma
and in
colon
carcinoma.
CaR signaling and effects have been studied in several cancers including ovarian cancers, gastrinomas, and gliomas in addition to comparatively detailed studies in breast, prostate, and
colon
cancers.
Pharmacological agonists and antagonists of CaR hold therapeutic promise depending on whether activation of CaR is required such as in case
of colon
cancer or inactivating the receptor is required as in the case of breast- and prostate tumors.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
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(PMID = 19011996.001).
[ISSN]
1355-008X
[Journal-full-title]
Endocrine
[ISO-abbreviation]
Endocrine
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Receptors, Calcium-Sensing
[Number-of-references]
203
55.
Dundar M, Caglayan AO, Saatci C, Karaca H, Baskol M, Tahiri S, Ozkul Y:
How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population.
Cancer Genet Cytogenet
; 2007 Sep;177(2):95-7
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[Title]
How the I1307K
adenomatous
polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population.
Germline and somatic truncating mutations of the
adenomatous
polyposis coli gene (APC) are thought to initiate colorectal tumor formation in familial
adenomatous
polyposis syndrome and sporadic colorectal carcinogenesis, respectively.
Genomic DNA was extracted from patients by obtaining all stomach and
colon
malign polipose tissues using nuclei lysis methods.
The APC I1307K allele was identified in 7 of 57 stomach carcinoma patients (12.3%; P > 0.05) and 30 of 56
colon
carcinoma patients (53.6%; P < 0.05) using antigen-anticor interaction methods.
Furthermore, APC I1307K carriers had greater numbers of
adenomas
and colorectal cancers per patient than noncarriers.
The conclusion is that the APC I1307K variant leads to increased
adenoma
formation and colorectal cancer.
The estimated relative risk for carriers may justify
specific
clinical screening for Turkish people expected to harbor this allele, and genetic testing in the long term may significantly promote colorectal cancer prevention in this population.
[MeSH-major]
Adenomatous
Polyposis Coli Protein / genetics. Colorectal Neoplasms / genetics. Genes, APC. Stomach Neoplasms / genetics
Genetic Alliance.
consumer health - Colorectal Cancer
.
Genetic Alliance.
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(PMID = 17854661.001).
[ISSN]
0165-4608
[Journal-full-title]
Cancer genetics and cytogenetics
[ISO-abbreviation]
Cancer Genet. Cytogenet.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Randomized Controlled Trial
[Publication-country]
United States
[Chemical-registry-number]
0 / Adenomatous Polyposis Coli Protein
56.
Pisello F, Geraci G, Arnone E, Modica G, Stassi F, Sciumè C:
[Endoscopic surveillance of colon-rectum in the narrow band imaging era].
G Chir
; 2009 Oct;30(10):440-4
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[Title]
[Endoscopic surveillance
of colon
-rectum in the narrow band imaging era].
[Transliterated title]
Sorveglianza endoscopica
del
colon
-retto. Ruolo
del
Narrow Band Imaging (NBI).
BACKGROUND AND AIMS: Colonoscopic surveillance is an established method of colorectal cancer (CRC) screening that reduces death rates, but has an
adenoma
miss rate of 10-20%.
Narrow band imaging (NBI), a novel endoscopic technology, highlights superficial mucosal capillaries and improves contrast for small
adenomas
.
This study evaluated the role of NBI in the improving
colon adenoma
detection.
PATIENTS AND METHODS: White light colonoscope was compared with NBI for
adenoma
detection during colonoscopy.
The outcome parameter was the difference in
the adenoma
detection rate between the two techniques.
All
polyps
detected were removed for histopathological analysis.
RESULTS:
Adenomas
were detected more frequently in the NBI group (51) than in the control group (49); however, the difference was not statistically significant (p = 0.128).
CONCLUSIONS: In our experience, the NBI did not increased the
adenomas
detection rate compared to white light by an endoscopist with a known high detection rate using white light.
[MeSH-major]
Adenoma
/ diagnosis. Colonoscopy / methods. Colorectal Neoplasms / diagnosis
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(PMID = 19954587.001).
[ISSN]
0391-9005
[Journal-full-title]
Il Giornale di chirurgia
[ISO-abbreviation]
G Chir
[Language]
ita
[Publication-type]
Comparative Study; English Abstract; Journal Article; Randomized Controlled Trial
[Publication-country]
Italy
57.
Ravizza D, Fiori G, Trovato C, Maisonneuve P, Bocciolone L, Crosta C:
Is colonoscopy a suitable investigation in the preoperative staging of ovarian cancer patients?
Dig Liver Dis
; 2005 Jan;37(1):57-61
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AIMS: The aim of this study was to evaluate the utility of preoperative colonoscopy in ovarian cancer patients and the prevalence of
adenomas
in this population.
All the
polyps
observed were removed.
Thirty-six
adenomas
were removed in 26 (20%) women.
An increased prevalence of
adenomas
was not observed in this population.
[MeSH-major]
Colonic
Neoplasms / secondary. Colonoscopy. Ovarian Neoplasms / pathology
[MeSH-minor]
Adenoma
/ pathology.
Adenoma
/ surgery. Adult. Aged. Aged, 80 and over.
Colon
/ pathology. Female. Humans. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Sensitivity and Specificity
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(PMID = 15702861.001).
[ISSN]
1590-8658
[Journal-full-title]
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
[ISO-abbreviation]
Dig Liver Dis
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
58.
Micheletto G, Sciannamea I, Zanoni A, Panizzo V, Rubino B, Danelli P:
[Intestinal neuroendocrine tumor. Case report and review of the literature].
Ann Ital Chir
; 2009 Jul-Aug;80(4):319-24
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Symptoms are
non specific
; the most common are abdominal pain, nausea and vomiting, weight loss and gastrointestinal (GI) blood loss.
Here we report a case of a 73-year-old male with an
adenomatous colonic polyp
, not suitable of endoscopic treatment, and a synchronous carcinoid of small intestine discovered during surgical procedure.
[MeSH-major]
Adenoma
. Carcinoid Tumor.
Colonic Polyps
. Ileal Neoplasms. Neoplasms, Multiple Primary. Sigmoid Neoplasms
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.
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.
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
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author profiles
.
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(PMID = 19967893.001).
[ISSN]
0003-469X
[Journal-full-title]
Annali italiani di chirurgia
[ISO-abbreviation]
Ann Ital Chir
[Language]
ita
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Italy
59.
Hurst NG, Stocken DD, Wilson S, Keh C, Wakelam MJ, Ismail T:
Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients.
Br J Cancer
; 2007 Oct 8;97(7):971-7
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Early detection of
polyps
or colorectal carcinoma can reduce colorectal carcinoma-associated deaths.
A total of 27 significant
adenomas
and 63 malignancies were identified.
[MeSH-major]
Adenoma
/ diagnosis. Biomarkers, Tumor / blood. Colorectal Neoplasms / diagnosis. Matrix Metalloproteinase 9 / blood
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consumer health - Colorectal Cancer
.
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(PMID = 17912241.001).
[ISSN]
0007-0920
[Journal-full-title]
British journal of cancer
[ISO-abbreviation]
Br. J. Cancer
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; EC 3.4.24.35 / Matrix Metalloproteinase 9
[Other-IDs]
NLM/ PMC2360395
60.
Armah HB, Krasinskas AM, Parwani AV:
Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case.
Diagn Pathol
; 2007;2:29
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[Title]
Tubular
adenoma
with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case.
We present the case of a 39-year-old male with a tubular
adenoma
with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty to enlarge a post-chemoradiation-induced shrunken bladder.
Histologic examination revealed a tubular
adenoma
with high-grade dysplasia.
There are only two previous reports of tubulovillous
adenoma
in ileal segment after ileocystoplasty, both without high-grade dysplasia.
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Eur Urol. 1999 Feb;35(2):98-101
[
9933802.001
]
[Cites]
Eur Urol. 1999 Dec;36(6):588-94
[
10559613.001
]
[Cites]
Dis Colon Rectum. 1999 Dec;42(12):1632-8
[
10613486.001
]
[Cites]
Urology. 1999 Sep;54(3):561
[
10754137.001
]
[Cites]
Urol Int. 2000;64(1):31-2
[
10782030.001
]
[Cites]
Cochrane Database Syst Rev. 2003;(1):CD003306
[
12535469.001
]
(PMID = 17697327.001).
[ISSN]
1746-1596
[Journal-full-title]
Diagnostic pathology
[ISO-abbreviation]
Diagn Pathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC1995190
61.
Scott RH, Mansour S, Pritchard-Jones K, Kumar D, MacSweeney F, Rahman N:
Medulloblastoma, acute myelocytic leukemia and colonic carcinomas in a child with biallelic MSH6 mutations.
Nat Clin Pract Oncol
; 2007 Feb;4(2):130-4
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[Title]
Medulloblastoma, acute myelocytic leukemia and
colonic
carcinomas in a child with biallelic MSH6 mutations.
Background A 13-year-old girl presented with rectal bleeding and was found to have two
colonic
carcinomas (stage Dukes' C) and multiple
colonic polyps
.
A three-generation family history identified no relatives with
colonic
carcinomas or polyposis.
Investigations Immunohistochemical analysis was performed on a sample of
colonic
adenoma
.
[MeSH-major]
Cerebellar Neoplasms / genetics.
Colonic
Neoplasms / genetics. DNA-Binding Proteins / genetics. Leukemia, Myeloid, Acute / genetics. Medulloblastoma / genetics
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(PMID = 17259933.001).
[ISSN]
1743-4262
[Journal-full-title]
Nature clinical practice. Oncology
[ISO-abbreviation]
Nat Clin Pract Oncol
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein
62.
Paulsen JE, Knutsen H, Ølstørn HB, Løberg EM, Alexander J:
Identification of flat dysplastic aberrant crypt foci in the colon of azoxymethane-treated A/J mice.
Int J Cancer
; 2006 Feb 1;118(3):540-6
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[Title]
Identification of flat dysplastic aberrant crypt foci in
the colon
of azoxymethane-treated A/J mice.
The role of aberrant crypt foci (ACF) as preneoplastic lesions in
colon
carcinogenesis is not clear.
At weeks 7-14, we examined the luminal surface of unsectioned
colon
preparations stained with methylene blue in the inverse light microscope.
In conclusion, our data indicate a development from flat ACF to
adenoma
characterized by aberrant activation of the Wnt signaling pathway and fast crypt multiplication.
[MeSH-major]
Azoxymethane / toxicity. Carcinogens / toxicity.
Colonic
Neoplasms / pathology. Hyperplasia / pathology. Precancerous Conditions / pathology
Mouse Genome Informatics (MGI).
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.
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[Copyright]
Copyright 2005 Wiley-Liss, Inc.
(PMID = 16094649.001).
[ISSN]
0020-7136
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Carcinogens; 0 / beta Catenin; 136601-57-5 / Cyclin D1; MO0N1J0SEN / Azoxymethane
63.
Kitade Y, Akao Y:
MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug.
J Pharmacol Sci
; 2010;114(3):276-80
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miRs) in colorectal tumors (63 cancer specimens and 65
adenoma
specimens) compared to adjacent
non
-tumorous tissues.
Decreased expression of miR-143 and -145 was frequently observed in
the adenoma
and cancer samples.
As the down-regulation of miR-143 and -145 was observed even in the early phase
of adenoma
formation, their decreased expression would appear to contribute mainly to the initiation of tumorigenesis.
[MeSH-minor]
Adenoma
/ genetics.
Adenoma
/ metabolism.
Adenoma
/ pathology. Animals. Cell Line, Tumor.
Colon
/ physiopathology. Down-Regulation. Growth Inhibitors. Humans. Mice. Xenograft Model Antitumor Assays
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(PMID = 20953119.001).
[ISSN]
1347-8648
[Journal-full-title]
Journal of pharmacological sciences
[ISO-abbreviation]
J. Pharmacol. Sci.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Japan
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Growth Inhibitors; 0 / MIRN143 microRNA, human; 0 / MIRN145 microRNA, human; 0 / MicroRNAs
64.
Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H:
EphB receptor activity suppresses colorectal cancer progression.
Nature
; 2005 Jun 23;435(7045):1126-30
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Here we show that, although Wnt signalling remains constitutively active, most human colorectal cancers lose expression of EphB at
the adenoma
-carcinoma transition.
Furthermore, reduction of EphB activity accelerates tumorigenesis in
the colon
and rectum of Apc(Min/+) mice, and results in the formation of aggressive adenocarcinomas.
[MeSH-minor]
Adenoma
/ metabolism.
Adenoma
/ pathology. Animals. Cell Line, Tumor. Disease Progression. Down-Regulation. Gene Expression Regulation, Neoplastic. Genes, APC. Genes, Dominant / genetics. Humans. Intercellular Signaling Peptides and Proteins / metabolism. Mice. Mice, Transgenic. Mutation / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Signal Transduction. Wnt Proteins
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(subscription/membership/fee required).
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.
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[ErratumIn]
Nature. 2005 Aug 11;436(7052):881. Jonkeer, Suzanne [corrected to Jonkheer, Suzanne]
(PMID = 15973414.001).
[ISSN]
1476-4687
[Journal-full-title]
Nature
[ISO-abbreviation]
Nature
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Wnt Proteins; EC 2.7.10.1 / Receptors, Eph Family
65.
Rohde F, Rimkus C, Friederichs J, Rosenberg R, Marthen C, Doll D, Holzmann B, Siewert JR, Janssen KP:
Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer.
Int J Cancer
; 2007 Oct 15;121(8):1717-23
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[Title]
Expression of osteopontin, a target gene of
de
-regulated Wnt signaling, predicts survival in
colon
cancer.
We analyzed 13 normal
colon
tissues, 9
adenomas
, 120 primary
colon
tumors, and 10 liver metastases by quantitative reverse-transcription PCR.
OPN expression was strongly elevated in primary
colon
cancer and liver metastasis, but not in pre-cancerous lesions and UICC stage I tumors.
Thus, OPN is a transcriptional target of aberrant Wnt signaling, and OPN expression alone predicts survival in human
colon
cancer.
[MeSH-major]
Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics.
Colonic
Neoplasms / chemistry.
Colonic
Neoplasms / mortality. Osteopontin / analysis. Osteopontin / genetics. Wnt Proteins / genetics
[MeSH-minor]
Adenoma
/ chemistry.
Adenoma
/ mortality. Aged. Animals.
Colon
/ chemistry. Female. Gene Expression Regulation, Neoplastic. Genes, APC. Humans. Liver Neoplasms / chemistry. Liver Neoplasms / mortality. Liver Neoplasms / secondary. Male. Mice. Middle Aged. Mutation. Precancerous Conditions / chemistry. Precancerous Conditions / mortality. Predictive Value of Tests. Prognosis. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Survival Analysis. Up-Regulation. beta Catenin / analysis. beta Catenin / genetics
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[Copyright]
(c) 2007 Wiley-Liss, Inc.
(PMID = 17565744.001).
[ISSN]
0020-7136
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Wnt Proteins; 0 / beta Catenin; 106441-73-0 / Osteopontin
66.
Leman ES, Schoen RE, Magheli A, Sokoll LJ, Chan DW, Getzenberg RH:
Evaluation of colon cancer-specific antigen 2 as a potential serum marker for colorectal cancer.
Clin Cancer Res
; 2008 Mar 1;14(5):1349-54
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[Title]
Evaluation
of colon
cancer-
specific
antigen 2 as a potential serum marker for colorectal cancer.
PURPOSE: A blood test to detect
colon
cancer at a preventable stage would represent a major advancement.
We have previously identified
colon
cancer-
specific
markers using focused proteomics analysis of nuclear structural proteins.
Two of these markers,
colon
cancer-
specific
antigen (CCSA)-3 and CCSA-4, have been developed into blood-based markers that are able to distinguish individuals with colorectal cancer from those without.
CCSA-2 is a distinct novel
colon
cancer marker identified using focused proteomics.
EXPERIMENTAL DESIGN: Using an indirect ELISA on serum samples obtained from two institutions, we evaluated CCSA-2 as a serum-based
colon
cancer marker.
A total of 111 serum samples from individuals who underwent colonoscopy and were subsequently diagnosed as either being normal or having hyperplastic
polyps
, nonadvanced
adenomas
, advanced
adenomas
, and colorectal cancer were evaluated.
CCSA-2 at a cutoff of 10.8 mug/mL has overall specificity of 78.4% [95% confidence interval (95% CI), 67.3-87.1%] and sensitivity of 97.3% (95% CI, 85.8-99.5%) in separating individuals with advanced
adenomas
and colorectal cancer from normal, hyperplastic, and nonadvanced
adenoma
populations.
CONCLUSION: Our initial study shows that CCSA-2 is a potential serum-based marker for
colon
cancer detection with high sensitivity and specificity.
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[RetractionIn]
Schoen RE, Magheli A, Sokoll LJ, Chan DW, Getzenberg RH. Clin Cancer Res. 2013 Jan 15;19(2):508
[
23271798.001
]
(PMID = 18316554.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / U01 CA084968; United States / NCI NIH HHS / CA / U01 CA084968-01; United States / NCI NIH HHS / CA / CA084968
[Publication-type]
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / colon cancer-specific antigen 2, human; 0 / colon-specific antigen
[Other-IDs]
NLM/ NIHMS371863; NLM/ PMC4664476
67.
Bhattacharya S, Mathew G, Jayne DG, Pelengaris S, Khan M:
15-lipoxygenase-1 in colorectal cancer: a review.
Tumour Biol
; 2009;30(4):185-99
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Of these enzymes, 15-LOX-1 is expressed in
colon
.
[MeSH-minor]
Adenoma
/ enzymology.
Adenoma
/ metabolism. Animals. Anticarcinogenic Agents / blood. Anticarcinogenic Agents / metabolism. Arachidonic Acid / metabolism. Cyclic GMP-Dependent Protein Kinases / metabolism. Disease Models, Animal. GATA6 Transcription Factor / metabolism. Humans. Intestinal Mucosa / enzymology. Intestinal Mucosa / metabolism. PPAR alpha / metabolism. PPAR delta / metabolism. PPAR gamma / genetics. PPAR gamma / metabolism. PPAR-beta / metabolism. Reference Values. Reverse Transcriptase Polymerase Chain Reaction
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(PMID = 19752603.001).
[ISSN]
1423-0380
[Journal-full-title]
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
[ISO-abbreviation]
Tumour Biol.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Anticarcinogenic Agents; 0 / GATA6 Transcription Factor; 0 / PPAR alpha; 0 / PPAR delta; 0 / PPAR gamma; 0 / PPAR-beta; 27YG812J1I / Arachidonic Acid; EC 1.13.11.33 / ALOX15B protein, human; EC 1.13.11.33 / Arachidonate 15-Lipoxygenase; EC 2.7.11.12 / Cyclic GMP-Dependent Protein Kinases
[Number-of-references]
110
68.
Ito H, Matsuo K, Hosono S, Watanabe M, Kawase T, Suzuki T, Hirai T, Yatabe Y, Tanaka H, Tajima K:
Association between CYP7A1 and the risk of proximal colon cancer in Japanese.
Int J Mol Epidemiol Genet
; 2010;1(1):35-46
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[Title]
Association between CYP7A1 and the risk of proximal
colon
cancer in Japanese.
Recently, an association between a polymorphism (-204A>C, rs3808607) in CYP7A1 and proximal
colon
cancer/
adenoma
has been reported, which was not observed with distal
colon
or rectal cancer/
adenoma
.
In this case-control study, we examined the association between haplotypes of CYP7A1 and proximal or distal
colon
/rectal cancer risk in a Japanese population.
Subjects were 96 cases of proximal
colon
cancer, 357 of distal
colon
/rectal cancer and 961 age- and sex-matched
non
-cancer controls at Aichi Cancer Center.
In locus-
specific
analyses, we saw no association with rs3808607 for any site.
Haplotype analyses revealed that the TAAGG haplotype was positively associated with proximal
colon
cancer [confounder-adjusted odds ratio: 1.72 (95% confidence interval: 1.10-2.71), p=0.018] but not with distal
colon
and rectal cancer combined.
Our results indicate that CYP7A1 plays a role in the carcinogenesis of colorectal cancer specifically in the proximal
colon
.
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[Cites]
Genet Anal. 1999 Feb;14(5-6):143-9
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J Lipid Res. 1999 Oct;40(10):1883-9
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(PMID = 21537451.001).
[ISSN]
1948-1756
[Journal-full-title]
International journal of molecular epidemiology and genetics
[ISO-abbreviation]
Int J Mol Epidemiol Genet
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC3076754
[Keywords]
NOTNLM ; CYP7A1 / Japanese / polymorphisms / proximal colon cancer
69.
Katznelson L:
Approach to the patient with persistent acromegaly after pituitary surgery.
J Clin Endocrinol Metab
; 2010 Sep;95(9):4114-23
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Acromegaly is a chronic and insidious disease that is associated with multisystem comorbidities, including cardiovascular disease, hypertension, sleep apnea syndrome,
colon
polyposis, arthropathy, and metabolic complications including glucose intolerance and type 2 diabetes mellitus.
[MeSH-major]
Acromegaly / therapy.
Adenoma
/ surgery. Algorithms. Growth Hormone-Secreting Pituitary
Adenoma
/ surgery. Postoperative Complications / therapy
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(PMID = 20823464.001).
[ISSN]
1945-7197
[Journal-full-title]
The Journal of clinical endocrinology and metabolism
[ISO-abbreviation]
J. Clin. Endocrinol. Metab.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
United States
[Number-of-references]
59
70.
Johnson PM, Gallinger S, McLeod RS:
Surveillance colonoscopy in individuals at risk for hereditary nonpolyposis colorectal cancer: an evidence-based review.
Dis Colon Rectum
; 2006 Jan;49(1):80-93; discussion 94-5
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However, given the potential for rapid progression from
adenoma
to carcinoma and missing lesions at colonoscopy, there is consensus that screening more frequently than every three years is required.
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[CommentIn]
Dis Colon Rectum. 2006 Nov;49(11):1797-8; author reply 1799
[
17053868.001
]
(PMID = 16284887.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Journal Article; Meta-Analysis
[Publication-country]
United States
71.
Femia AP, Dolara P, Giannini A, Salvadori M, Biggeri A, Caderni G:
Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis.
Cancer Res
; 2007 Jan 15;67(2):445-9
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[Title]
Frequent mutation of Apc gene in rat
colon
tumors and mucin-depleted foci, preneoplastic lesions in experimental
colon
carcinogenesis.
Mucin-depleted foci (MDF) are microscopic dysplastic lesions induced in
the colon
of rodents by
specific
colon
carcinogens.
Because Apc is a member of the Wnt pathway and the most frequent mutated gene in human
colon
cancer, we tested whether MDF harbor Apc mutations.
We screened a segment of the Apc gene comprising the region homologous to the mutation cluster region (MCR) of human APC, which frequently shows mutations in experimental
colon
tumors.
These results show that Apc mutations are present in MDF with a frequency similar to that of tumors, strengthening the evidence that they are precancerous lesions in
colon
carcinogenesis.
[MeSH-major]
Colonic
Neoplasms / genetics. Genes, APC. Mucins / deficiency. Mutation. Precancerous Conditions / genetics
[MeSH-minor]
Adenocarcinoma / genetics. Adenocarcinoma / metabolism.
Adenoma
/ genetics.
Adenoma
/ metabolism. Animals. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / metabolism. Male. Rats. Rats, Inbred F344
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(PMID = 17234750.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Mucins
72.
Robertson DJ, Greenberg ER, Beach M, Sandler RS, Ahnen D, Haile RW, Burke CA, Snover DC, Bresalier RS, McKeown-Eyssen G, Mandel JS, Bond JH, Van Stolk RU, Summers RW, Rothstein R, Church TR, Cole BF, Byers T, Mott L, Baron JA:
Colorectal cancer in patients under close colonoscopic surveillance.
Gastroenterology
; 2005 Jul;129(1):34-41
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We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and
adenoma
with high-grade dysplasia.
METHODS: Patients were drawn from 3
adenoma
chemoprevention trials.
All underwent baseline colonoscopy with removal of at least one
adenoma
and were deemed free of remaining lesions.
We identified patients subsequently diagnosed with invasive cancer or
adenoma
with high-grade dysplasia.
The cancers were located in all regions of the
colon
; 10 were at or proximal to the hepatic flexure.
Seven patients were diagnosed with
adenoma
with high-grade dysplasia during follow-up.
Older patients and those with a history of more
adenomas
were at higher risk of being diagnosed with invasive cancer or
adenoma
with high-grade dysplasia.
[MeSH-major]
Adenoma
/ diagnosis.
Adenoma
/ epidemiology. Colonoscopy. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology
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[CommentIn]
Gastroenterology. 2006 Feb;130(2):620-1; author reply 621-2
[
16472624.001
]
[CommentIn]
Gastroenterology. 2006 Feb;130(2):622-3; author reply 623
[
16472627.001
]
(PMID = 16012932.001).
[ISSN]
0016-5085
[Journal-full-title]
Gastroenterology
[ISO-abbreviation]
Gastroenterology
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA 23108; United States / NCI NIH HHS / CA / CA 59005; United States / NCI NIH HHS / CA / CA46927
[Publication-type]
Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
73.
Suzui M, Inamine M, Kaneshiro T, Morioka T, Yoshimi N, Suzuki R, Kohno H, Tanaka T:
Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis.
Int J Oncol
; 2005 Nov;27(5):1391-9
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[Title]
Indole-3-carbinol inhibits the growth of human
colon
carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat
colon
carcinogenesis.
The purpose of this study was to examine the effects of I3C on
colon
carcinogenesis, cell proliferation, cell-cycle progression and apoptosis, and on the levels of expression of several cell-cycle control molecules.
We used a long-term rat model by using azoxymethane (AOM) to induce tumors (
adenomas
and adenocarcinomas) in
the colon
.
In addition, the tumor multiplicity
of adenoma
plus adenocarcinoma and the volume of adenocarcinoma were also increased by 2.0- (P<0.00001) and 2.1-fold (P<0.05) respectively, compared to the control.
I3C significantly increased the proliferating cell nuclear antigen labeling index (PCNA LI) (P<0.008) and decreased the apoptotic index (P<0.05) of the
colon
adenocarcinoma.
In contrast, in HCT 116 and HT29 human
colon
carcinoma cells, I3C inhibited growth and induced G1-phase cell-cycle arrest and apoptosis.
These results suggest that I3C inhibits the growth of human
colon
carcinoma cells, at least in part, by inducing p27KIP1 and p21CIP1-mediated G1 cell-cycle arrest but dietary I3C promotes AOM-induced rat
colon
carcinogenesis by inhibiting the apoptosis
of colon
tumors.
[MeSH-major]
Adenocarcinoma / pathology. Antioxidants / pharmacology.
Colonic
Neoplasms / pathology. Indoles / pharmacology
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(PMID = 16211236.001).
[ISSN]
1019-6439
[Journal-full-title]
International journal of oncology
[ISO-abbreviation]
Int. J. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Greece
[Chemical-registry-number]
0 / Antioxidants; 0 / Indoles; C11E72455F / indole-3-carbinol
74.
Cirocchi R, Coccetta M, De Sol A, Morelli U, Spizzirri A, Cattorini L, Farinella E, Giustozzi G, Sciannameo F:
[Minimally invasive treatment of synchronous colorectal tumours].
Chir Ital
; 2008 Mar-Apr;60(2):237-41
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[Transliterated title]
Trattamento mini-invasivo delle neoplasie sincrone
del
colon
-retto.
In patients with colorectal cancers synchronous neoplastic lesions are an increasingly frequent finding at preoperative staging; 3% of the cases are other cancers while 33-35% of the synchronous lesions are villous
adenomas
.
The treatment of most colorectal
adenomas
can be performed by endoscopic poplypectomy.
Surgical timing involved performing a sequential exeresis characterised by a cancer resection, followed by resection of the voluminous
adenoma
: TEM for rectal cancer followed by a laparoscopic right hemicolectomy with an extracorporeal anastomosis for a voluminous villous
adenoma
(1 patient) and laparoscopic right hemicolectomy with an extracorporeal anastomosis for cancer followed by TEM for a voluminous villous
adenoma
(2 patients).
One patient with left
colon
cancer associated with a voluminous villous rectal
adenoma
first underwent TEM for the rectal
adenoma
and then a left laparoscopic hemicolectomy with an extracorporeal anastomosis in order to ease the transit of the circular mechanical stapler.
Another patient with rectal and right
colon
adenomas
first underwent TEM for a voluminous rectal sessile
adenoma
and later a right hemicolectomy.
[MeSH-major]
Adenoma
/ surgery. Colectomy / methods. Colorectal Neoplasms / surgery. Laparoscopy. Microsurgery
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(PMID = 18689172.001).
[ISSN]
0009-4773
[Journal-full-title]
Chirurgia italiana
[ISO-abbreviation]
Chir Ital
[Language]
ita
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Italy
75.
Bini EJ, Park J, Francois F:
Use of flexible sigmoidoscopy to screen for colorectal cancer in HIV-infected patients 50 years of age and older.
Arch Intern Med
; 2006 Aug 14-28;166(15):1626-31
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The prevalence of neoplastic lesions (
adenomas
or adenocarcinomas) in the distal
colon
was significantly higher in HIV-infected patients than in control subjects (25.5% vs 13.1%, P<.001), and the odds of HIV-infected patients having a neoplastic lesion was significantly higher even after adjustment for potential confounding variables (odds ratio, 2.34; 95% confidence interval, 1.60-3.44).
The prevalence of
adenomas
of any size (25.5% vs 12.9%, P<.001) and advanced neoplasia (7.3% vs 3.8%, P = .03) in the distal
colon
was significantly higher in HIV-infected patients.
Among individuals with positive results on flexible sigmoidoscopy, proximal
colonic
neoplastic lesions on follow-up colonoscopy were more common in HIV-infected patients after adjustment for age, sex, and race/ethnicity (odds ratio, 1.88; 95% confidence interval, 1.02-3.46).
CONCLUSIONS: Patients infected with HIV are more likely to have
colonic
neoplasms on screening flexible sigmoidoscopy than those without HIV, and these individuals should be offered colorectal cancer screening.
[MeSH-minor]
Adenocarcinoma / epidemiology.
Adenoma
/ epidemiology. Aged. Female. Health Status. Humans. Male. Middle Aged
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.
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.
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(PMID = 16908796.001).
[ISSN]
0003-9926
[Journal-full-title]
Archives of internal medicine
[ISO-abbreviation]
Arch. Intern. Med.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
76.
Worrell RT, Best A, Crawford OR, Xu J, Soleimani M, Matthews JB:
Apical ammonium inhibition of cAMP-stimulated secretion in T84 cells is bicarbonate dependent.
Am J Physiol Gastrointest Liver Physiol
; 2005 Oct;289(4):G768-78
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Normal human
colonic
luminal (NH(4)(+)) concentration ([NH(4)(+)]) ranges from approximately 10 to 100 mM.
However, the nature of the effects of NH(4)(+) on transport, as well as NH(4)(+) transport itself, in
colonic
epithelium is poorly understood.
We elucidate here the effects of apical NH(4)(+) on cAMP-stimulated Cl(-) secretion in
colonic
T84 cells.
However, apical NH(4)(+) inhibition of current was prevented by 10 min of pretreatment of the apical surface with 500 microM DIDS, 100 microM 4,4'-dinitrostilbene-2,2'-disulfonic acid (DNDS), or 25 microM niflumic acid, suggesting a role for NH(4)(+) action through an apical anion exchanger. mRNA and protein for the apical anion exchangers SLC26A3 [downregulated in
adenoma
(DRA)] and SLC26A6 [putative anion transporter (PAT1)] were detected in T84 cells by RT-PCR and Northern and Western blots.
[MeSH-major]
Bicarbonates / metabolism.
Colon
/ metabolism. Cyclic AMP / antagonists & inhibitors. Cyclic AMP / pharmacology. Quaternary Ammonium Compounds / pharmacology
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CARBACHOL CHLORIDE
.
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(PMID = 16002564.001).
[ISSN]
0193-1857
[Journal-full-title]
American journal of physiology. Gastrointestinal and liver physiology
[ISO-abbreviation]
Am. J. Physiol. Gastrointest. Liver Physiol.
[Language]
eng
[Grant]
United States / NIDDK NIH HHS / DK / DK-051630; United States / NIDDK NIH HHS / DK / DK-62809
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Antiporters; 0 / Bicarbonates; 0 / Carbonic Anhydrase Inhibitors; 0 / Chloride Channels; 0 / Membrane Transport Proteins; 0 / Muscarinic Agonists; 0 / Quaternary Ammonium Compounds; 0 / SLC26A6 protein, human; 0 / Slc26a3 protein, rat; 0 / Stilbenes; 128-42-7 / 4,4'-dinitro-2,2'-stilbenedisulfonic acid; 8Y164V895Y / Carbachol; E0399OZS9N / Cyclic AMP; Q1O6DSW23R / 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
77.
Jalving M, de Jong S, Koornstra JJ, Boersma-van Ek W, Zwart N, Wesseling J, de Vries EG, Kleibeuker JH:
TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas.
Clin Cancer Res
; 2006 Jul 15;12(14 Pt 1):4350-6
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[Title]
TRAIL induces apoptosis in human colorectal
adenoma
cell lines and human colorectal
adenomas
.
The aim of this study was to investigate whether it is possible to induce apoptosis in human
adenoma
cell lines and human
adenomas
using rhTRAIL.
EXPERIMENTAL DESIGN: Two human
adenoma
cell lines were exposed to 0.1 microg/mL of rhTRAIL for 5 hours.
Short-term explant cultures were established from freshly removed human
adenomas
(n = 38) and biopsies of normal
colon
epithelium (n = 15), and these were incubated for 5 hours in the presence or absence of 1 microg/mL of rhTRAIL.
RESULTS: In
the adenoma
cell lines, rhTRAIL induced up to 55% apoptosis.
This coincided with caspase-8 and caspase-3 activation and could be inhibited by a pan-caspase inhibitor. rhTRAIL induced caspase-dependent apoptosis in
adenomas
with high-grade dysplasia (n = 21) compared with the paired untreated counterparts (apoptotic index, 34 +/- 5% versus 17 +/- 2%, mean +/- SE; P = 0.002), but not in
adenomas
with low-grade dysplasia (n = 17) or in normal
colon
epithelium (n = 15).
CONCLUSIONS: Colorectal
adenoma
cell lines and
adenomas
with high-grade dysplasia are sensitive to rhTRAIL-induced apoptosis, whereas normal
colon
epithelium is not.
This suggests the potential application of rhTRAIL in the treatment of
adenomas
with high-grade dysplasia.
[MeSH-major]
Adenoma
/ metabolism.
Adenoma
/ pathology. Apoptosis. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. TNF-Related Apoptosis-Inducing Ligand / physiology
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[CommentIn]
Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4132-6
[
16857782.001
]
(PMID = 16857810.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Apoptosis Regulatory Proteins; 0 / Ligands; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFSF10 protein, human; EC 3.4.22.- / Caspases
78.
Sillars-Hardebol AH, Carvalho B, de Wit M, Postma C, Delis-van Diemen PM, Mongera S, Ylstra B, van de Wiel MA, Meijer GA, Fijneman RJ:
Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression.
Tumour Biol
; 2010 Apr;31(2):89-96
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[Title]
Identification of key genes for carcinogenic pathways associated with colorectal
adenoma
-to-carcinoma progression.
Colorectal
adenomas
form a biologically and clinically distinct intermediate stage in development of colorectal cancer (CRC) from normal
colon
epithelium.
Only 5% of
adenomas
progress into adenocarcinomas, indicating that malignant transformation requires other biological alterations than those involved in
adenoma
formation.
The present study aimed to explore which cancer-related biological processes are affected during colorectal
adenoma
-to-carcinoma progression and to identify key genes within these pathways that can serve as tumor markers for malignant transformation.
The activity of 12 cancer-related biological processes was compared between 37 colorectal
adenomas
and 31 adenocarcinomas, using the pathway analysis tool Gene Set Enrichment Analysis.
Expression of six gene sets was significantly increased in CRCs compared to
adenomas
, representing chromosomal instability, proliferation, differentiation, invasion, stroma activation, and angiogenesis.
For AURKA and PDGFRB, increased mRNA expression levels were verified at the protein level by immunohistochemical analysis of a series of
adenomas
and CRCs.
[MeSH-major]
Adenoma
/ genetics. Carcinoma / genetics. Colorectal Neoplasms / genetics
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18829976.001
]
(PMID = 20358421.001).
[ISSN]
1423-0380
[Journal-full-title]
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
[ISO-abbreviation]
Tumour Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Cell Cycle Proteins; 0 / Proto-Oncogene Proteins; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.11.1 / AURKA protein, human; EC 2.7.11.1 / Aurora Kinase A; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / polo-like kinase 1
[Other-IDs]
NLM/ PMC2848338
79.
Popivanova BK, Li YY, Zheng H, Omura K, Fujii C, Tsuneyama K, Mukaida N:
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.
Cancer Sci
; 2007 Mar;98(3):321-8
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[Title]
Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human
colon
cancer cells and can prevent Bad-mediated apoptosis.
Because Pim-3 protein was not detected in normal
colon
mucosal tissues, we evaluated Pim-3 expression in malignant lesions of human
colon
, another endoderm-derived organ.
Pim-3 was detected immunohistochemically in well-differentiated (43/68 cases) and moderately differentiated (23/41 cases) but not poorly differentiated
colon
adenocarcinomas (0/5 cases).
Moreover, Pim-3 proteins were detected in
adenoma
(35/40 cases) and normal mucosa (26/111 cases), which are adjacent to adenocarcinoma.
Furthermore, in human
colon
cancer tissues, Pim-3 co-localized with Bad in all cases (9/9) and with phospho-Ser(112)Bad in most cases (6/9).
These observations suggest that Pim-3 can inactivate Bad by phosphorylating its Ser(112) in human
colon
cancer cells and thus may prevent apoptosis and promote progression of human
colon
cancer.
[MeSH-major]
Colonic
Neoplasms / enzymology.
Colonic
Neoplasms / genetics. Protein-Serine-Threonine Kinases / genetics. Protein-Serine-Threonine Kinases / metabolism. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. bcl-Associated Death Protein / antagonists & inhibitors
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(PMID = 17270021.001).
[ISSN]
1347-9032
[Journal-full-title]
Cancer science
[ISO-abbreviation]
Cancer Sci.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Proto-Oncogene Proteins; 0 / bcl-Associated Death Protein; EC 2.7.11.1 / PIM3 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
80.
Park HW, Kang HC, Kim IJ, Jang SG, Kim K, Yoon HJ, Jeong SY, Park JG:
Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers.
Int J Cancer
; 2007 Jan 1;120(1):7-12
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Using methylation-
specific
PCR and bisulfite sequencing, we analyzed the methylation status in primary CRC,
adenomas
and corresponding normal tissues and then compared it with the presence of K-ras and BRAF mutations.
In primary CRC, the frequency of RASSF2A methylation was 72.6%, and it was found in 16 of 16 (100%)
adenomas
.
[MeSH-minor]
Adenoma
/ genetics.
Adenoma
/ pathology. Case-Control Studies. Cell Line, Tumor.
Colon
/ metabolism. DNA Mutational Analysis. DNA Repair. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Microsatellite Instability. Middle Aged. Neoplasm Staging. Promoter Regions, Genetic / genetics. Rectum / metabolism. Tumor Suppressor Proteins
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(PMID = 17013898.001).
[ISSN]
0020-7136
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Proteins; 0 / RASSF2 protein, human; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
81.
Tonelli F, Garcea A, Batignani G:
Different role of the colonic pouch for low anterior resection and coloanal anastomosis.
Tech Coloproctol
; 2005 Apr;9(1):15-20
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[Title]
Different role of the
colonic
pouch for low anterior resection and coloanal anastomosis.
BACKGROUND: Functional outcome after sphincter-saving operations can be improved by
colonic
pouch compared to the straight procedure.
However, it is not clear whether the
colonic
pouch has a different behavior in patients treated by low anterior resection with colorectal (LAR) or coloanal anastomosis (CAA).
METHODS: We evaluated the 1-year results of 75 patients who underwent a sphincter-saving operation for rectal carcinoma or villous tumor of the middle or lower third of the rectum: 18 patients underwent coloanal anastomosis (CAA), in 13 patients we performed a coloanal anastomosis with a
colonic
pouch (PCAA), 20 patients had low anterior resection (LAR) and 24 had LAR with pouch construction (PLAR).
CONCLUSIONS:
Colonic
J-pouch provides an advantage over straight anastomosis in sphincter-saving operations by reducing the daily number of defecations, and the frequencies of fecal soiling and urgency.
[MeSH-major]
Anal Canal / surgery.
Colon
/ surgery.
Colonic
Pouches
[MeSH-minor]
Adenoma
, Villous / surgery. Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Carcinoma / surgery. Female. Humans. Male. Manometry. Middle Aged. Rectal Neoplasms / surgery. Rectum / surgery
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(PMID = 15868493.001).
[ISSN]
1123-6337
[Journal-full-title]
Techniques in coloproctology
[ISO-abbreviation]
Tech Coloproctol
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Italy
82.
Roy HK, Turzhitsky V, Kim YL, Goldberg MJ, Muldoon JP, Liu Y, Brand RE, Hall C, Hasabou N, Jameel M, Backman V:
Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study.
Dis Colon Rectum
; 2008 Sep;51(9):1381-6
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[Title]
Spectral slope from the endoscopically-normal mucosa predicts concurrent
colonic
neoplasia: a pilot ex-vivo clinical study.
METHODS: Subjects (n = 127) undergoing colonoscopy had spectral slope determined from two endoscopically normal midtransverse
colonic
biopsies using four-dimensional elastic light-scattering fingerprinting and correlated with clinical findings.
There was a corresponding decrease in spectral slope values from the endoscopically normal mucosa in subjects harboring
adenomas
(n = 41) and advanced
adenomas
(n = 10), compared to neoplasia-free subjects (P </= 0.00001).
These factors did not appear to be confounded by either age or
adenoma
location.
For detecting advanced
adenomas
, spectral slope had a negative and positive predictive value of 95 percent and 50 percent respectively.
CONCLUSIONS: We demonstrate, for the first time, that spectral slope in "normal" mucosa can accurately risk-stratify patients for
colonic
neoplasia.
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(PMID = 18536963.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA112315; United States / NCI NIH HHS / CA / U01 CA111257; United States / NIBIB NIH HHS / EB / EB003682-01A2; United States / NCI NIH HHS / CA / CA112315-01A1; United States / NCI NIH HHS / CA / R01 CA112315-01A1; United States / NCI NIH HHS / CA / R01 CA109861; United States / NIBIB NIH HHS / EB / R01 EB003682-01A2; United States / NIBIB NIH HHS / EB / R01 EB003682
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ NIHMS58195; NLM/ PMC2913285
83.
Kirimlioglu H, Kirimlioglu V, Yilmaz S, Sagir V, Coban S, Turkmen E, Hilmioglu F:
Role of matrix metalloproteinase-7 in colorectal adenomas.
Dig Dis Sci
; 2006 Nov;51(11):2068-72
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[Title]
Role of matrix metalloproteinase-7 in colorectal
adenomas
.
They are known to be overexpressed as normal mucosa progresses to
adenomas
and carcinomas.
In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of
colonic adenomas
.
Although MMP-7 has already been shown to be overexpressed in various types of
colonic adenomas
, tubular versus villous
adenomas
had not been further seperated to date.
Seventy-six patients had either normal mucosa (n=15) or tubular (n=32), tubulovillous (n=16), or villous (n=13)
colonic
adenoma
.
Each
adenoma
was graded according to the percentage of strongly stained areas in
the adenoma
as G0, G1, G2, or G3.
Sixty-nine percent of villous
adenomas
showed grade 3 staining of MMP-7, versus none of the tubular
adenomas
.
G0 and G1 staining was not detected in the villous
adenomas
.
The results of the study show that the degrees of overexpression of the three subtypes of
colonic adenomas
were statistically significantly different.
In conclusion, MMP-7 overexpression is thought to be an early event in
the adenoma
-carcinoma pathway.
[MeSH-major]
Adenoma
/ enzymology. Colorectal Neoplasms / enzymology. Matrix Metalloproteinase 7 / physiology
[MeSH-minor]
Adenoma
, Villous / enzymology.
Adenoma
, Villous / pathology. Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prospective Studies
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Dis Colon Rectum. 2002 Apr;45(4):537-43
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12006939.001
]
(PMID = 17009118.001).
[ISSN]
0163-2116
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
84.
Wargovich MJ:
What do diet-induced alterations in colorectal polyps and aberrant crypts indicate for risk?
J Nutr
; 2006 Oct;136(10):2679S-80S
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[Title]
What do diet-induced alterations in colorectal
polyps
and aberrant crypts indicate for risk?
[MeSH-major]
Colon
/ pathology.
Colonic
Neoplasms.
Colonic Polyps
. Diet. Rectal Neoplasms
[MeSH-minor]
Adenoma
/ pathology.
Adenoma
/ prevention & control. Animals. Calcium, Dietary / administration & dosage. Fruit. Humans. Precancerous Conditions / pathology. Vegetables
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(PMID = 16988147.001).
[ISSN]
0022-3166
[Journal-full-title]
The Journal of nutrition
[ISO-abbreviation]
J. Nutr.
[Language]
eng
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Calcium, Dietary
85.
Park JK, Hong R, Kim KJ, Lee TB, Lim SC:
Significance of p-STAT3 expression in human colorectal adenocarcinoma.
Oncol Rep
; 2008 Sep;20(3):597-604
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A total of 127 invasive CRA, 20 colorectal
adenomas
and 20 normal mucosae were obtained.
The statistically significant difference of immunoreactivity for p-STAT3 between the CRA and
adenoma
, and between the CRA and normal mucosae was identified.
[MeSH-minor]
Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / secondary.
Adenoma
/ genetics.
Adenoma
/ metabolism.
Adenoma
/ pathology. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Carcinoma in Situ / genetics. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology.
Colon
/ metabolism.
Colon
/ pathology. Humans. Immunoenzyme Techniques. Neoplasm Invasiveness. Neoplasm Staging. Phosphorylation. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction
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(PMID = 18695911.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
eng
[Publication-type]
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
[Publication-country]
Greece
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human
86.
Dong K, Li B, Li BH, Guan QL, Huo YZ:
[Clinical analysis of Peutz-Jeghers syndrome:a report of 6 cases].
Zhonghua Wei Chang Wai Ke Za Zhi
; 2005 Jul;8(4):336-8
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RESULTS: Repeated abdominal pain, intussusception and intestinal
polyp
with bleeding were main manifestations.
Case 4 and case 5 underwent laparotomy for many times because of intussusceptions caused by
polyps
or recurrent abdominal pain.
Case 1 and case 4 had
polyps
synchronous with
adenoma
, and case 2 had
polyp
with gastric cancer.
Main treatment included
polyp
resection and partial small intestinal and
colon
resection.
CONCLUSIONS: Patients with PJS have family history of cancer and a high incidence of
polyp
recurrence of small intestine.
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(PMID = 16167257.001).
[ISSN]
1671-0274
[Journal-full-title]
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
[ISO-abbreviation]
Zhonghua Wei Chang Wai Ke Za Zhi
[Language]
chi
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
China
87.
Park DH, Kim HS, Kim WH, Kim TI, Kim YH, Park DI, Kim HJ, Yang SK, Byeon JS, Lee MS, Chung IK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS:
Clinicopathologic characteristics and malignant potential of colorectal flat neoplasia compared with that of polypoid neoplasia.
Dis Colon Rectum
; 2008 Jan;51(1):43-9; discussion 49
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METHODS: A prospective, cross-sectional study of 3,360 patients diagnosed with
adenomas
via total colonoscopy and polypectomy was performed at 11 tertiary medical centers between July 2003 and July 2004.
If multiple
adenomas
were identified, then only
the adenoma
with the most advanced degree of histology was recorded for the patient.
Patients with flat neoplasias tended to be older (59.6 vs. 57.1, P < 0.01), with the neoplasia located more frequently in the right
colon
than polypoid neoplasias (49.3 percent vs. 32 percent, P < 0.01).
Multivariate analysis revealed that a size of > or =11 mm (odds ratio, 6.8; 95 percent confidence interval, 4.8-9.7) and location in the left
colon
(odds ratio, 1.6; 95 percent confidence interval, 1.1-2.4) were significant determinants for the malignancy potential of
colonic
neoplasias.
CONCLUSIONS: The clinicopathologic indices for the propensity of malignant transformation in colorectal neoplasias were a size > or =11 mm and location in the left
colon
rather than flat gross morphology.
[MeSH-major]
Adenoma
/ pathology.
Colonic Polyps
/ pathology. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology
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(PMID = 18034359.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Multicenter Study
[Publication-country]
United States
88.
Soon MS, Soon A, Lin TY, Lin OS:
Distribution of colon neoplasia in Chinese patients: implications for endoscopic screening strategies.
Eur J Gastroenterol Hepatol
; 2008 Jul;20(7):642-7
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[Title]
Distribution
of colon
neoplasia in Chinese patients: implications for endoscopic screening strategies.
OBJECTIVES: Our aim was to measure the prevalence and distribution of
colonic
neoplasia in Chinese adults, and to estimate the sensitivity of sigmoidoscopic screening strategies for detecting those with advanced neoplasia.
The prevalence and distribution of
colonic
neoplasia and advanced neoplasia (defined as an
adenoma
>or=10 mm or with villous, high-grade dysplastic, or malignant features) were reviewed retrospectively and the outcomes of various sigmoidoscopic screening strategies estimated.
Overall, 24 patients had advanced neoplasia in the proximal
colon
, of whom four had synchronous distal neoplasia.
[MeSH-minor]
Adenoma
/ diagnosis.
Adenoma
/ ethnology.
Adenoma
/ pathology. Age Distribution. Aged. Colonoscopy. Epidemiologic Methods. Female. Humans. Male. Middle Aged. Sex Distribution. Taiwan / epidemiology
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(PMID = 18679066.001).
[ISSN]
0954-691X
[Journal-full-title]
European journal of gastroenterology & hepatology
[ISO-abbreviation]
Eur J Gastroenterol Hepatol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
89.
Pellisé M, Fernández-Esparrach G, Cárdenas A, Sendino O, Ricart E, Vaquero E, Gimeno-García AZ, de Miguel CR, Zabalza M, Ginès A, Piqué JM, Llach J, Castells A:
Impact of wide-angle, high-definition endoscopy in the diagnosis of colorectal neoplasia: a randomized controlled trial.
Gastroenterology
; 2008 Oct;135(4):1062-8
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BACKGROUND & AIMS: It is essential to optimize standard colonoscopy technique to be able to increase
polyp
detection.
Morphology, size, location, and pathologic diagnosis of each
polyp
were recorded.
Pathology examination was feasible in 418 lesions (272
adenomas
, 109 hyperplastic
polyps
, and 37 inflammatory lesions).
Both techniques detected a similar number and type of lesions, and there were no differences in the distribution along
the colon
, in the degree of dysplasia, or morphology of
adenomas
.
The per-patient basis analyses demonstrated that there were no differences between the 2 arms of the study in the detection rates of
polyps
(SC, 0.84 +/- 1.59; HDE, 0.83 +/- 1.30),
adenomas
(0.45 +/- 1.07 vs 0.43 +/- 0.87), small
adenomas
(0.22 +/- 0.71 vs 0.28 +/- 0.78), flat
adenomas
(0.30 +/- 0.91 vs 0.21 +/- 0.63), or hyperplastic
polyps
(0.16 +/- 0.50 vs 0.18 +/- 0.54).
[MeSH-major]
Adenomatous Polyps
/ pathology. Colorectal Neoplasms / pathology. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Endoscopy, Gastrointestinal / standards
[MeSH-minor]
Adenoma
/ pathology. Adult. Aged. Female. Humans. Male. Middle Aged. Patient Selection. Reproducibility of Results
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[CommentIn]
Gastroenterology. 2008 Oct;135(4):1035-7
[
18786535.001
]
(PMID = 18725223.001).
[ISSN]
1528-0012
[Journal-full-title]
Gastroenterology
[ISO-abbreviation]
Gastroenterology
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Validation Studies
[Publication-country]
United States
90.
Ma DF, Kondo T, Nakazawa T, Niu DF, Mochizuki K, Kawasaki T, Yamane T, Katoh R:
Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells.
Hum Pathol
; 2010 Nov;41(11):1550-7
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[Title]
Hypoxia-inducible adenosine A2B receptor modulates proliferation
of colon
carcinoma cells.
In this study, we examined the expression pattern of adenosine receptors in various colorectal tissues and human
colon
carcinoma cell lines and investigated the biologic functions regarding
colon
carcinogenesis.
Using reverse transcriptase polymerase chain reaction and Western blotting, we found that adenosine receptor A2B (ADORA2B) was consistently up-regulated in colorectal carcinoma tissues and
colon
cancer cell lines compared with normal colorectal mucosa.
In immunohistochemistry, we observed diffuse immunopositivity of ADORA2B in 67% of colorectal adenocarcinomas (39/58), 17% of tubular
adenomas
(5/30), and 0% of normal
colon
glands (0/62).
During a hypoxic state, there was also a significant induction of ADORA2B expression in the messenger RNA level at 8 hours of incubation and in the protein level at 24 hours of incubation in
colon
carcinoma cell lines.
To examine the function of ADORA2B, we applied an ADORA2B-selective antagonist (MRS1754) to
the colon
carcinoma cells, which significantly inhibited cell growth in a dose-dependent manner as demonstrated with a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell proliferation assay.
[MeSH-major]
Adenocarcinoma / pathology.
Adenoma
/ pathology. Colorectal Neoplasms / pathology. Receptor, Adenosine A2B / metabolism
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[Copyright]
Copyright © 2010 Elsevier Inc. All rights reserved.
(PMID = 20619442.001).
[ISSN]
1532-8392
[Journal-full-title]
Human pathology
[ISO-abbreviation]
Hum. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Acetamides; 0 / Adenosine A2 Receptor Antagonists; 0 / Antineoplastic Agents; 0 / N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide; 0 / Purines; 0 / RNA, Messenger; 0 / Receptor, Adenosine A2B
91.
Kalady MF, McGannon E, Vogel JD, Manilich E, Fazio VW, Church JM:
Risk of colorectal adenoma and carcinoma after colectomy for colorectal cancer in patients meeting Amsterdam criteria.
Ann Surg
; 2010 Sep;252(3):507-11; discussion 511-3
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[Title]
Risk of colorectal
adenoma
and carcinoma after colectomy for colorectal cancer in patients meeting Amsterdam criteria.
Therefore, when
colon
cancer is diagnosed, total rather than segmental colectomy is advocated.
However, information about
adenoma
and carcinoma risk after index surgery is still underreported.
Metachronous colorectal
adenoma
and carcinoma development were the primary end points.
In 74 patients (33%), 256
adenomas
were detected, including 140 high-risk
adenomas
in 48 patients (22%).
By comparison, 4 of 38 patients (11%) who underwent total colectomy developed subsequent high-risk
adenomas
and 3 (8%) developed metachronous cancer.
CONCLUSIONS: Amsterdam patients undergoing partial colectomy have a high rate of metachronous high-risk
adenomas
and carcinomas.
For either surgical option, yearly endoscopic surveillance is essential to remove premalignant
adenomas
.
[MeSH-major]
Adenoma
/ epidemiology. Carcinoma / epidemiology. Colectomy / methods. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / surgery. Neoplasms, Second Primary / epidemiology
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(PMID = 20739851.001).
[ISSN]
1528-1140
[Journal-full-title]
Annals of surgery
[ISO-abbreviation]
Ann. Surg.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
92.
Paik SS, Jang SM, Jang KS, Lee KH, Choi D, Jang SJ:
Leptin expression correlates with favorable clinicopathologic phenotype and better prognosis in colorectal adenocarcinoma.
Ann Surg Oncol
; 2009 Feb;16(2):297-303
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Leptin expression was evaluated on the tissue microarray of 44 normal
colon
mucosal tissues, 44
adenomatous polyps
, and 437 colorectal adenocarcinomas by immunohistochemistry.
Frequency of leptin expression was dramatically increased from normal
colonic
mucosa (2/44, 4.5%) to
adenomas
(13/44, 29.5%) and adenocarcinomas (321/437, 73.5%) as neoplastic progression.
We conclude that leptin was gradually expressed during the normal-
adenoma
-adenocarcinoma sequence, suggesting an association in colorectal carcinogenesis.
[MeSH-minor]
Adenoma
/ metabolism.
Adenoma
/ pathology.
Adenomatous Polyps
/ metabolism.
Adenomatous Polyps
/ pathology. Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child.
Colon
/ metabolism.
Colon
/ pathology. Female. Humans. Immunoenzyme Techniques. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Phenotype. Survival Rate. Tissue Array Analysis. Young Adult
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(PMID = 19050975.001).
[ISSN]
1534-4681
[Journal-full-title]
Annals of surgical oncology
[ISO-abbreviation]
Ann. Surg. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Leptin
93.
Løvig T, Andersen SN, Clausen OP, Rognum TO:
Microsatellite instability in long-standing ulcerative colitis.
Scand J Gastroenterol
; 2007 May;42(5):586-91
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OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory disease of the
colon
associated with a high risk of developing colorectal cancer.
RESULTS: High-level MSI (MSI-H) was detected in one villous
adenoma
with high-grade dysplasia and right-sided location.
CONCLUSIONS: This study suggests that MSI is rare in UC-related neoplasia as well as
non
-neoplastic lesions, and does not contribute to the development of dysplasia.
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(PMID = 17454879.001).
[ISSN]
0036-5521
[Journal-full-title]
Scandinavian journal of gastroenterology
[ISO-abbreviation]
Scand. J. Gastroenterol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Norway
[Chemical-registry-number]
0 / BAT26 microsatellite DNA; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Genetic Markers
94.
Daniel P, Wagrowska-Danilewicz M, Danilewicz M, Stasikowska O, Malecka-Panas E:
Transforming growth factor beta 1 and metalloproteinase-9 overexpression in colorectal cancer (CC) and adenoma.
Int J Colorectal Dis
; 2007 Oct;22(10):1165-72
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[Title]
Transforming growth factor beta 1 and metalloproteinase-9 overexpression in colorectal cancer (CC) and
adenoma
.
The aim of the study was to determine the pattern of immunohistochemical expression of TGFbeta1, MMP-9, and Ki-67 in CC and
adenomatous polyps
.
PATIENT/METHODS: The study group comprised 50 patients with colorectal
polyps
and 33 patients with CC.
Endoscopically removed
polyps
and CC biopsies had been evaluated with histopatologic examination and immunohistochemistry.
RESULTS: Among 62
adenomas
, 33 high-grade dysplasia (HGD) and 29 low-grade dysplasia (LGD) had been detected.
Mean TGFbeta1, MMP-9, and Ki-67 LI in CC were significantly higher (p < 0.01, 0.01, and 0.01, respectively) than in HGD
polyps
.
Mean TGFbeta1, MMP-9, and Ki-67 LI in HGD
polyps
were significantly higher than in LGD
polyps
(p < 0.01, 0.01, and 0.01, respectively).
CONCLUSION: The increased expression of TGFbeta1, MMP-9 observed in colorectal
adenomas
seems to be related to the grade of dysplasia.
[MeSH-major]
Adenoma
/ metabolism. Colorectal Neoplasms / metabolism. Matrix Metalloproteinase 9 / metabolism. Transforming Growth Factor beta1 / metabolism
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(PMID = 17394006.001).
[ISSN]
0179-1958
[Journal-full-title]
International journal of colorectal disease
[ISO-abbreviation]
Int J Colorectal Dis
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Ki-67 Antigen; 0 / Transforming Growth Factor beta1; EC 3.4.24.35 / Matrix Metalloproteinase 9
95.
Oberwalder M, Zitt M, Wöntner C, Fiegl H, Goebel G, Zitt M, Köhle O, Mühlmann G, Ofner D, Margreiter R, Müller HM:
SFRP2 methylation in fecal DNA--a marker for colorectal polyps.
Int J Colorectal Dis
; 2008 Jan;23(1):15-9
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[Title]
SFRP2 methylation in fecal DNA--a marker for colorectal
polyps
.
INTRODUCTION: DNA methylation of secreted frizzled-related proteins (SFRPs) can be detected in colorectal cancer (CRC) tissue, in tissue of
adenomas
, and in aberrant crypt foci, whereas in normal colorectal mucosa tissue, SFRP genes are unmethylated.
The purpose of this study was to clarify whether SFRP2 methylation in fecal DNA can be found in stool of individuals with hyperplastic and
adenomatous
colorectal
polyps
.
MATERIALS AND METHODS: Patients who were diagnosed with colorectal
polyps
or showed negative colonoscopy were included in this study.
RESULTS: Stool samples from 68 individuals were checked for DNA content; 23% of the samples (6 of 26) from healthy controls, 46% of the samples (6 of 13) from patients with hyperplastic
polyps
, and 45% of the samples (13 of 29) from patients with
adenomas
were positive for human DNA.
SFRP2 methylation in stool samples was found in none of the healthy controls, in 33% (2 of 6) patients with hyperplastic
polyps
, and in 46% (6 of 13) patients with
adenomas
.
Statistical analysis revealed that the frequency of SFRP2 methylation increased significantly (P=0.028) from healthy controls to patients with hyperplastic
polyps
and to patients with
adenomas
.
CONCLUSIONS: In the current study, we report for the first time that SFRP2 methylation in fecal DNA increases significantly from healthy controls to patients with hyperplastic
polyps
and to patients with
adenomas
.
SFRP2 methylation may serve as a marker for molecular stool-based
adenoma
and CRC screening.
[MeSH-major]
Adenomatous Polyps
/ genetics. Biomarkers, Tumor / genetics.
Colonic Polyps
/ genetics. Colorectal Neoplasms / genetics. DNA Methylation. Gene Expression Regulation, Neoplastic. Membrane Proteins / genetics. Precancerous Conditions / genetics
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