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1. Halldorsson A, Dissanaike S, Kaye KS: Alveolar adenoma of the lung: a clinicopathological description of a case of this very unusual tumour. J Clin Pathol; 2005 Nov;58(11):1211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar adenoma of the lung: a clinicopathological description of a case of this very unusual tumour.
  • Alveolar adenomas are extremely rare, and are probably benign lung tumours of unknown histogenesis.
  • This report describes a case of alveolar adenoma in a 43 year old white man, who presented with pleuritic chest pain.
  • Although a positron emission tomography scan seemed to document the benign nature of the lesion, a thoracoscopic wedge resection was performed to alleviate the symptoms and verify the diagnosis.
  • [MeSH-major] Adenoma / pathology. Lung Neoplasms / pathology

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  • (PMID = 16254114.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1770767
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2. Saito EH, de Aaraujo LR, Carneiro LH, de Oliveira Neto AA, Correa JC, Teixeira LS: Alveolar adenoma. J Bras Pneumol; 2006 May-Jun;32(3):267-9
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  • [Title] Alveolar adenoma.
  • Alveolar adenoma is a rare benign neoplasm of the lungs, and very few cases have been described in the literature.
  • Patients with alveolar adenoma are frequently asymptomatic and are diagnosed through the accidental discovery of a singular, well-delineated nodule on a routine chest X-ray.
  • [MeSH-major] Adenoma / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 17273617.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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3. Stojsić J, Milenković B, Radojicić J, Percinkovski M: [Alveolar adenoma -- a rare lung tumour]. Srp Arh Celok Lek; 2007 Jul-Aug;135(7-8):461-4
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  • [Title] [Alveolar adenoma -- a rare lung tumour].
  • INTRODUCTION: Alveolar adenoma belongs to the group of benign epithelial tumours.
  • Histogenesis of alveolar adenoma is a combination of proliferation of alveolar pneumocytes and fibrous tissue originating from septal mesenchyma.
  • Tumourous nodule had a multicystic appearance and histologically, histochemically and immunohistochemically, an alveolar adenoma was estimated.
  • CONCLUSION: Alveolar adenoma is a rare benign lung tumour, most frequently presented as a solitary pulmonary nodule.
  • It is necessary to take into consideration alveolar adenoma, too, when a solitary pulmonary nodule is diagnosed.
  • [MeSH-major] Adenoma / diagnosis. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis

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  • (PMID = 17929540.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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4. Glaab R, Turina M, Achermann E, Maurer R, Went P, Schöb O: [Alveolar adenoma--a rare pulmonary mass: case report and review of the literature]. Zentralbl Chir; 2009 Sep;134(5):478-80
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  • [Title] [Alveolar adenoma--a rare pulmonary mass: case report and review of the literature].
  • Definitive histology following thoracoscopic wedge resection showed the distinctive findings of an alveolar adenoma, a very rare benign tumour of the lung of unknown histogenesis.
  • Alveolar adenoma usually presents as a peripheral solitary lesion in asymptomatic, older patients.
  • Its histological features, the benign proliferation of alveolar epithelium and septal mesenchyme, allow for its distinction from other benign lesions of the lung.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma, Bronchogenic / diagnosis. Lung Neoplasms / diagnosis

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  • [Copyright] (c) Georg Thieme Verlag Stuttgart-New York.
  • (PMID = 19757349.001).
  • [ISSN] 1438-9592
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 5
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5. Redente EF, Orlicky DJ, Bouchard RJ, Malkinson AM: Tumor signaling to the bone marrow changes the phenotype of monocytes and pulmonary macrophages during urethane-induced primary lung tumorigenesis in A/J mice. Am J Pathol; 2007 Feb;170(2):693-708
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  • Neutrophils infiltrated the alveoli of tumor-bearing lungs and within the periphery of macroscopic adenomas and adenocarcinomas.

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  • (PMID = 17255336.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA033497; United States / NCI NIH HHS / CA / R01 CA096133; United States / NCI NIH HHS / CA / CA33497; United States / NCI NIH HHS / CA / CA96133
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinogens; 3IN71E75Z5 / Urethane; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.13.39 / Nos2 protein, mouse
  • [Other-IDs] NLM/ PMC1851863
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6. Sak SD, Koseoglu RD, Demirag F, Akbulut H, Gungor A: Alveolar adenoma of the lung. Immunohistochemical and flow cytometric characteristics of two new cases and a review of the literature. APMIS; 2007 Dec;115(12):1443-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar adenoma of the lung. Immunohistochemical and flow cytometric characteristics of two new cases and a review of the literature.
  • Alveolar adenoma is a rare and benign tumour of the lung that usually presents in asymptomatic patients as a coin lesion on chest radiography.
  • Alveolar adenoma has a characteristic multicystic histology and often resembles the normal lung parenchyma.
  • Immunohistochemical analysis may aid in the characterization of alveolar adenoma and discriminate this condition from other types of benign lesions of the lung.
  • An indolent clinical progression and absence of recurrence and metastasis after complete resection are the most important characteristics indicative of the benign nature of alveolar adenoma.
  • Few studies have been conducted at the molecular level, such as by flow cytometry, with the objective of characterizing the biological nature of alveolar adenoma.
  • Differential diagnoses include sclerosing hemangioma, papillary adenoma, lymphangioma, atypical adenomatous hyperplasia and bronchioloalveolar carcinoma.
  • [MeSH-major] Adenoma / pathology. Pulmonary Alveoli / pathology. Solitary Pulmonary Nodule / pathology

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  • (PMID = 18184418.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53
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7. Melnick RL, Nyska A, Foster PM, Roycroft JH, Kissling GE: Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice. Toxicology; 2007 Feb 12;230(2-3):126-36
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  • In the 2-year studies, neoplasms were induced at multiple sites in rats and mice exposed to DBA; these included mononuclear cell leukemia and abdominal cavity mesothliomas in rats, and neoplasms of the liver (hepatocellular adenoma or carcinoma and hepatoblastoma) and lung (alveolar adenoma or carcinoma) in mice.

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  • (PMID = 17157429.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Acetates; 631-64-1 / dibromoacetic acid
  • [Other-IDs] NLM/ NIHMS17825; NLM/ PMC1905493
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8. Minato H, Kaji S, Kinoshita E, Kurose N, Nojima T, Kohno M, Konuma K, Ikawa H: Solitary intrapulmonary cystic lymphangioma in an infant: a case report with literature review. Pathol Res Pract; 2010 Dec 15;206(12):851-6
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  • Differential diagnoses included lobar or interstitial emphysema, bronchogenic cyst, congenital pulmonary airway malformation and alveolar adenoma.

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20952134.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Homeodomain Proteins; 0 / Tumor Suppressor Proteins; 0 / monoclonal antibody D2-40; 0 / prospero-related homeobox 1 protein
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9. Nakamura H, Adachi Y, Arai T, Miwa K, Haruki T, Fujioka S, Taniguchi Y: A small alveolar adenoma resected by thoracoscopic surgery. Ann Thorac Surg; 2009 Mar;87(3):956-7
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  • [Title] A small alveolar adenoma resected by thoracoscopic surgery.
  • Alveolar adenoma (AA) is a rare lung benign tumor originated from type II pneumocytes.
  • There have been no reported cases of recurrence after a resection of AA, but a subsequent increase in such cases is expected, and we believe that it is necessary to understand the characteristics of this typical benign lung tumor.
  • [MeSH-major] Adenoma / surgery. Lung Neoplasms / surgery. Thoracoscopy

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  • (PMID = 19231437.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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10. North DW, Abdo KM, Benson JM, Dahl AR, Morris JB, Renne R, Witschi H: A review of whole animal bioassays of the carcinogenic potential of naphthalene. Regul Toxicol Pharmacol; 2008 Jul;51(2 Suppl):S6-14
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  • A statistically significant increased incidence of pulmonary alveolar/bronchiolar adenoma (a benign lesion), was observed among female mice; an observed increase among the males did not reach statistical significance.
  • A tumorigenic response was observed in both sexes of rats, in males an increased incidence of nasal respiratory epithelium adenoma (a benign rather than malignant lesion) and in females, olfactory epithelial neuroblastoma.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Administration, Inhalation. Animals. Bronchi / drug effects. Bronchi / pathology. Esthesioneuroblastoma, Olfactory / chemically induced. Esthesioneuroblastoma, Olfactory / pathology. Female. Inhalation Exposure. Lung Neoplasms / chemically induced. Lung Neoplasms / pathology. Male. Mice. Nasal Cavity / drug effects. Nasal Cavity / pathology. Nose Neoplasms / chemically induced. Nose Neoplasms / pathology. Olfactory Mucosa / drug effects. Olfactory Mucosa / pathology. Pulmonary Alveoli / drug effects. Pulmonary Alveoli / pathology. Rats

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  • (PMID = 18364246.001).
  • [ISSN] 1096-0295
  • [Journal-full-title] Regulatory toxicology and pharmacology : RTP
  • [ISO-abbreviation] Regul. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens, Environmental; 0 / Naphthalenes
  • [Number-of-references] 33
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11. Zhang Y, Zhi XY, Chen L, Wang DY, Li Y, Wang RT, Hu M, Liu L, Qian K: [Diagnosis and treatment of atypical adenomatous pulmonary hyperplasia in lungs]. Zhonghua Yi Xue Za Zhi; 2010 Dec 21;90(47):3355-8
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  • The alveolar interval had a slight increase.
  • [MeSH-major] Adenoma / pathology. Lung Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Pulmonary Alveoli / pathology. Retrospective Studies

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  • (PMID = 21223753.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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12. Oda E, Nakamura Y, Yamamoto M, Kojiro M: Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues. Kurume Med J; 2005;52(4):117-25
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  • Tubulin beta II was detected in various normal tissues, particularly in fetal and neonatal tissues, such as the nervous system, pulmonary alveoli, bronchioles and bronchi, colon, pancreatic ducts and acini, renal convoluted tubuli, skin epidermis, body cavity mesothelial cells, smooth muscle and thymus.
  • In neoplastic tissues, tubulin beta II immunoreactivity was detected in various nervous system neoplasms and other neoplasms such as pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma.
  • We conclude that our monoclonal antibody, KNY379, may be useful as a marker of nervous system neoplasm, pancreatic solid cystic carcinoma, pleomorphic adenoma, Warthin's tumor, nephroblastoma, basal cell carcinoma and malignant mesothelioma.

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  • (PMID = 16639982.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protein Isoforms; 0 / Tubulin
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13. Hahn FF, Gigliotti AP, Hutt JA, March TH, Mauderly JL: A review of the histopathology of cigarette smoke-induced lung cancer in rats and mice. Int J Toxicol; 2007 Jul-Aug;26(4):307-13
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  • Proliferative epithelial lesions are present in the lungs of both species and are apparent antecedent lesions to benign and malignant tumors.
  • Both species have alveolar epithelia hyperplasia, alveolar adenomas, and alveolar carcinomas.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Lung Neoplasms / etiology. Precancerous Conditions / etiology. Pulmonary Alveoli / drug effects. Smoking / adverse effects

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  • (PMID = 17661221.001).
  • [ISSN] 1091-5818
  • [Journal-full-title] International journal of toxicology
  • [ISO-abbreviation] Int. J. Toxicol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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14. Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, Price RE, Hittelman WN, Wistuba II, Kurie JM: Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res; 2005 Apr 15;65(8):3226-35
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  • [Title] Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
  • Here, we report that mTOR inhibition blocked malignant progression in K-ras(LA1) mice, which undergo somatic activation of the K-ras oncogene and display morphologic changes in alveolar epithelial cells that recapitulate those of precursors of human lung adenocarcinoma.
  • Levels of phospho-S6(Ser236/235), a downstream mediator of mTOR, increased with malignant progression (normal alveolar epithelial cells to adenocarcinoma) in K-ras(LA1) mice and in patients with lung adenocarcinoma.
  • Atypical alveolar hyperplasia, an early neoplastic change, was prominently associated with macrophages and expressed high levels of phospho-S6(Ser236/235).
  • mTOR inhibition in K-ras(LA1) mice by treatment with the rapamycin analogue CCI-779 reduced the size and number of early epithelial neoplastic lesions (atypical alveolar hyperplasia and adenomas) and induced apoptosis of intraepithelial macrophages.
  • Lastly, conditioned medium from primary cultures of alveolar macrophages stimulated the proliferation of LKR-13 cells.
  • [MeSH-major] Adenocarcinoma / enzymology. Genes, ras / genetics. Lung Neoplasms / enzymology. Precancerous Conditions / enzymology. Protein Kinase Inhibitors / pharmacology. Protein Kinases / metabolism. Pulmonary Alveoli / pathology. Sirolimus / analogs & derivatives. Sirolimus / pharmacology
  • [MeSH-minor] Adenoma / drug therapy. Adenoma / enzymology. Adenoma / genetics. Adenoma / pathology. Animals. Cell Line, Tumor. Cell Transformation, Neoplastic / drug effects. Cell Transformation, Neoplastic / metabolism. Disease Progression. Enzyme Activation. Hyperplasia. Macrophages, Alveolar / drug effects. Macrophages, Alveolar / enzymology. Macrophages, Alveolar / pathology. Mice. Mutation. Protein-Serine-Threonine Kinases / metabolism. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-akt. Ribosomal Protein S6 Kinases / biosynthesis. TOR Serine-Threonine Kinases

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  • (PMID = 15833854.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / P50 CA070907; United States / NCI NIH HHS / CA / R01 CA105155
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Proto-Oncogene Proteins; 624KN6GM2T / temsirolimus; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases; W36ZG6FT64 / Sirolimus
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15. Nakanishi K, Kumaki F, Hiroi S, Mukai M, Ikeda E, Kawai T: Mre11 expression in atypical adenomatous hyperplasia and adenocarcinoma of the lung. Arch Pathol Lab Med; 2006 Sep;130(9):1330-4
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  • OBJECTIVE: To investigate Mre11 in atypical adenomatous hyperplasia (AAH) and nonmucinous bronchioloalveolar carcinoma (NMBAC), an issue not previously explored.
  • CONCLUSIONS: On this basis, we suggest that the part played by Mre11 in telomere maintenance may not be important for the progression of the adenoma-carcinoma (AAH-NMBAC) sequence in the lung, although some role for it in carcinogenesis cannot be completely ruled out.
  • [MeSH-minor] Bronchial Neoplasms / genetics. Bronchial Neoplasms / pathology. Humans. Hyperplasia. Immunohistochemistry. Pulmonary Alveoli / pathology. RNA, Messenger / genetics. Retrospective Studies. Telomere / genetics

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  • (PMID = 16948520.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / MRE11A protein, human; 0 / RNA, Messenger
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16. Hutt JA, Vuillemenot BR, Barr EB, Grimes MJ, Hahn FF, Hobbs CH, March TH, Gigliotti AP, Seilkop SK, Finch GL, Mauderly JL, Belinsky SA: Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways. Carcinogenesis; 2005 Nov;26(11):1999-2009
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  • This study demonstrated that life time whole body exposures of female B6C3F1 mice to mainstream cigarette smoke at 250 mg total particulate matter/m(3) for 6 h per day, 5 days a week induces marked increases in the incidence of focal alveolar hyperplasias, pulmonary adenomas, papillomas and adenocarcinomas.
  • [MeSH-minor] Adenocarcinoma / chemically induced. Adenocarcinoma / genetics. Adenocarcinoma / secondary. Adenoma / chemically induced. Adenoma / genetics. Adenoma / pathology. Administration, Inhalation. Animals. Apoptosis Regulatory Proteins. Body Weight. Calcium-Calmodulin-Dependent Protein Kinases / genetics. Cell Proliferation / drug effects. Death-Associated Protein Kinases. Female. Genes, ras / drug effects. Hyperplasia / chemically induced. Hyperplasia / genetics. Hyperplasia / pathology. Incidence. Mice. Mice, Inbred Strains. Organ Size. Papilloma / chemically induced. Papilloma / genetics. Papilloma / pathology. Point Mutation. Promoter Regions, Genetic. Pulmonary Alveoli / drug effects. Pulmonary Alveoli / metabolism. Pulmonary Alveoli / pathology. Receptors, Retinoic Acid / genetics. Survival Rate

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  • [ErratumIn] Carcinogenesis. 2005 Dec;26(12):2214
  • (PMID = 15944214.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES08801; United States / NCRR NIH HHS / RR / RR00136CA
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Receptors, Retinoic Acid; 0 / retinoic acid receptor beta; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
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17. Yang YS, Yang MC, Guo Y, Williams OW, Weissler JC: PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. Am J Physiol Lung Cell Mol Physiol; 2009 Sep;297(3):L455-66
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  • [Title] PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity.
  • Pleomorphic adenoma gene like-2 (PLAGL2), a zinc finger DNA-binding protein, is a transcription factor of the surfactant protein C (SP-C) promoter.
  • Ectopic PLAGL2 was also expressed in alveolar type II cells of induced mice.
  • Defective alveolar septa and degraded airway fragments were found in the lesions of emphysematous lungs, indicating chronic airway destruction.
  • Finally, increased expression of PLAGL2 in alveolar epithelial cells correlated with the development of emphysema in the lung of COPD patients.

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  • (PMID = 19574421.001).
  • [ISSN] 1522-1504
  • [Journal-full-title] American journal of physiology. Lung cellular and molecular physiology
  • [ISO-abbreviation] Am. J. Physiol. Lung Cell Mol. Physiol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R03-HL-095407
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BNip3 protein, mouse; 0 / DNA-Binding Proteins; 0 / Membrane Proteins; 0 / Mitochondrial Proteins; 0 / Plagl2 protein, mouse; 0 / Pulmonary Surfactant-Associated Protein C; 0 / RNA-Binding Proteins; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2739772
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18. Floyd HS, Farnsworth CL, Kock ND, Mizesko MC, Little JL, Dance ST, Everitt J, Tichelaar J, Whitsett JA, Miller MS: Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis; 2005 Dec;26(12):2196-206
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  • [Title] Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.
  • To determine the effects of expression of mutant Ki-ras on lung tumorigenesis, we developed a bitransgenic mouse model that expresses the human Ki-ras(G12C) allele in alveolar type II and/or Clara cells in a tetracycline-inducible, lung-specific manner.
  • These results describe a novel mouse lung tumor model demonstrating benign tumor development in the absence of tumor progression, which will provide a new tool for understanding the early stages of lung tumor pathogenesis.

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  • (PMID = 16051643.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / T32 ES007331; United States / NCI NIH HHS / CA / R01 CA91909; United States / NCI NIH HHS / CA / R01 CA091909-02; United States / NCI NIH HHS / CA / P30 CA12197; United States / NCI NIH HHS / CA / R01 CA091909-02S1; United States / NCI NIH HHS / CA / R01 CA091909; United States / NIEHS NIH HHS / ES / T32-ES07331; United States / NCI NIH HHS / CA / R01 CA091909-04S1; United States / NCI NIH HHS / CA / R01 CA091909-04; United States / NCI NIH HHS / CA / R01 CA091909-03S1; United States / NCI NIH HHS / CA / P30 CA012197; United States / NCI NIH HHS / CA / R01 CA091909-01A1; United States / NCI NIH HHS / CA / R01 CA091909-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; EC 2.7.1.- / MAP-kinase-activated kinase 2; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / RPS6KA1 protein, human; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 90-kDa; EC 2.7.11.1 / Rps6ka1 protein, mouse; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.6.5.2 / ral GTP-Binding Proteins; N12000U13O / Doxycycline
  • [Other-IDs] NLM/ NIHMS6241; NLM/ PMC1351110
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19. Xie XY, Shen J, Xu LY, Li EM, Shen ZY: Bronchogenic and alveologenic tumors in mice induced by N-nitrosopiperidine. Biochem Cell Biol; 2010 Aug;88(4):775-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All tumors found in the experimental group originated from alveolar type II epithelial cells.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / genetics. Adenoma / pathology. Adenoma / ultrastructure. Animals. Carcinoma, Squamous Cell / chemically induced. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / ultrastructure. Female. Gene Expression Regulation, Neoplastic. Genes, bcl-2. Genes, myc. Genes, p53. Genes, ras. Male. Mice. Mice, Inbred BALB C. Pulmonary Alveoli / drug effects. Pulmonary Alveoli / metabolism. Pulmonary Alveoli / pathology. Pulmonary Alveoli / ultrastructure. Telomerase / genetics. Telomerase / metabolism

  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • Hazardous Substances Data Bank. N-NITROSOPIPERIDINE .
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  • (PMID = 20651851.001).
  • [ISSN] 1208-6002
  • [Journal-full-title] Biochemistry and cell biology = Biochimie et biologie cellulaire
  • [ISO-abbreviation] Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Nitrosamines; 6N066XUL4L / N-nitrosopiperidine; EC 2.7.7.49 / Telomerase; EC 2.7.7.49 / Tert protein, mouse
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20. Petrella F, Rizzo S, Pelosi G, Borri A, Galetta D, Gasparri R, Solli P, Veronesi G, Spaggiari L: Giant alveolar adenoma causing severe dyspnoea. J Thorac Oncol; 2010 Jul;5(7):1088-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant alveolar adenoma causing severe dyspnoea.
  • [MeSH-major] Adenoma / complications. Dyspnea / etiology. Lung Neoplasms / complications. Pulmonary Alveoli / pathology

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  • (PMID = 20581577.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. González ET, Sánchez-Yuste R, Jiménez-Heffernan JA: Cytologic features of pulmonary alveolar adenoma. Acta Cytol; 2008 Nov-Dec;52(6):739-40
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic features of pulmonary alveolar adenoma.
  • [MeSH-major] Adenoma / pathology. Lung Neoplasms / pathology. Pulmonary Alveoli / pathology

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  • (PMID = 19068683.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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22. Dirksen A: Adenocarcinoma. Clin Respir J; 2008 Apr;2(2):129
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenoma / pathology. Bronchi / pathology. Humans. Hyperplasia. Male. Middle Aged. Pulmonary Alveoli / pathology. Tomography, X-Ray Computed

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  • (PMID = 20298319.001).
  • [ISSN] 1752-699X
  • [Journal-full-title] The clinical respiratory journal
  • [ISO-abbreviation] Clin Respir J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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