[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 147
1. Miwa S, Taya T: [A case of Sertoli cell tumor]. Hinyokika Kiyo; 2005 Dec;51(12):821-3
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of Sertoli cell tumor].
  • We report a case of Sertoli cell tumor.
  • An elastic firm induration larger than a hen's egg in size was palpable on the surface of the left testis.
  • Tumor markers for testicular tumor such as human chorionic gonadotropin-beta, alpha fetoprotein, and lactate dehydrogenase were not elevated.
  • However, ultrasound showed a low echoic mass in the left testis.
  • Therefore, we performed left high orchiectomy under the diagnosis of left testicular tumor.
  • Its histology showed Sertoli cell tumor.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16440732.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


2. Matsuu A, Hashizume T, Kanda T, Nagano M, Sugiyama A, Okamoto Y, Hikasa Y: A case of persistent Müllerian duct syndrome with sertoli cell tumor and hydrometra in a dog. J Vet Med Sci; 2009 Mar;71(3):379-81
SciCrunch. OMIA - Online Mendelian Inheritance in Animals: Data: Gene Expression .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of persistent Müllerian duct syndrome with sertoli cell tumor and hydrometra in a dog.
  • Upon exploratory laparotomy, two tumors and a connecting structure similar to fluid-filled uterus were recognized.
  • After cytological and bacterial examinations of the fluid and histological examination, this dog was diagnosed with bilateral Sertoli cell tumor with hydrometra.

  • MedlinePlus Health Information. consumer health - Uterine Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19346713.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


3. National Toxicology Program: Toxicology and carcinogenesis studies of cumene (CAS No. 98-82-8) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2009 Feb;(542):1-200
Hazardous Substances Data Bank. Isopropylbenzene .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomas of the respiratory epithelium of the nose were observed in male and female rats, and male rats had increased incidences of renal tubule adenoma or carcinoma (combined) and interstitial cell adenoma of the testis.
  • Adenomas and carcinomas of the lung were markedly increased in male and female mice exposed to cumene.
  • The rate of liver neoplasms was also increased in exposed female mice, and a few hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland were seen in male mice exposed to the highest concentration of cumene.
  • CONCLUSIONS: We conclude that the increased occurrences of adenomas of the epithelium of the nose in male and female rats, of renal tubule adenoma or carcinoma (combined), of adenomas and carcinomas of the lung in male and female mice, and of liver neoplasms in female mice were caused by exposure to cumene.
  • The occurrence of interstitial cell adenoma of the testis in male rats and hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland in male mice may also have been associated with exposure to cumene.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19340095.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzene Derivatives; 8Q54S3XE7K / cumene
  •  go-up   go-down


Advertisement
4. Kawakami E, Hirano T, Hori T, Tsutsui T: Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis. J Vet Med Sci; 2007 Dec;69(12):1259-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
  • The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively.
  • The rate of occurrence of SCT in the cryptorchid testis was very high (71%).
  • The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-alpha concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis.
  • The low SOD activity in the cryptorchid testis, low blood plasma INH-alpha concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18176022.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / HSP70 Heat-Shock Proteins; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 1.15.1.1 / Superoxide Dismutase
  •  go-up   go-down


5. Calcagno C: Sclerosing Sertoli cell tumor of the testis. Urologia; 2007 Jan-Mar;74(1):37-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing Sertoli cell tumor of the testis.
  • Sclerosing Sertoli cell tumor of the testis is a very rare neoplasm.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21086416.001).
  • [ISSN] 0391-5603
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


6. Miller MA, Hartnett SE, Ramos-Vara JA: Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. Vet Pathol; 2007 May;44(3):394-7
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interstitial cell tumor and Sertoli cell tumor in the testis of a cat.
  • Testicular tumors are rarely reported in cats.
  • We describe a case of interstitial cell tumor and Sertoli cell tumor in a cat that developed aggressive behavior and inappropriate urination 7 years after it was obtained from a shelter as an allegedly castrated 2 year old.
  • Testes were not palpable, but the left testis was found in the scrotum by surgical exploration and was mostly replaced by the 2 tumors.
  • The interstitial cell tumor, but not the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with steroid production.
  • Behavior improved after excision of the testis and penile papillae began to regress, but the cat was euthanatized 3 1/2 months after castration at the owner's request.
  • Neither tumor had metastasized.
  • The right testis was never found and was presumed to have been removed during the reported castration procedure.
  • [MeSH-major] Cat Diseases / pathology. Leydig Cell Tumor / veterinary. Sertoli Cell Tumor / veterinary

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17491086.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


7. Abbas F, Bashir NW, Hussainy AS: Sclerosing Sertoli cell tumor of the testis. J Coll Physicians Surg Pak; 2005 Jul;15(7):437-8
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing Sertoli cell tumor of the testis.
  • Sclerosing Sertoli-cell tumor is a rare, sex-cord-stromal tumor of the testis with distinct clinical and pathological features with only 14 such cases reported in contemporary literature.
  • We report such a tumor in a young diabetic and hypertensive male.
  • Pathological examination of right radical orchidectomy specimen was consistent with sclerosing sub-type of Sertoli-cell testicular tumor with no invasion.
  • He remains free of disease recurrence at 6 years following surgery.
  • [MeSH-major] Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Comorbidity. Diabetes Mellitus / epidemiology. Humans. Hypertension / epidemiology. Male. Sertoli Cells / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16197877.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  •  go-up   go-down


8. Sasaki M, Ota S: [A case of sertoli cell tumor with arteriovenous malformation]. Hinyokika Kiyo; 2010 Jan;56(1):55-8
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of sertoli cell tumor with arteriovenous malformation].
  • Ultrasonography and computed tomography (CT) demonstrated hematoma and testicular tumor with abundant blood flow in the right testis.
  • Radical orchiectomy was performed under a diagnosis of right testicular tumor.
  • Histological analysis of the lesion indicated a Sertoli cell tumor.
  • [MeSH-major] Arteriovenous Malformations / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testis / blood supply

  • MedlinePlus Health Information. consumer health - Arteriovenous Malformations.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20104012.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


9. Estep JS, Baumgartner RE, Townsend F, Pabst DA, McLellan WA, Friedlaender A, Dunn DG, Lipscomb TP: Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus). Vet Pathol; 2005 May;42(3):357-9
MedlinePlus Health Information. consumer health - Pheochromocytoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus).
  • Sertoli cell tumor and pheochromocytoma were also diagnosed in the spotted dolphin.
  • This is the first report of seminoma, Sertoli cell tumor, and pheochromocytoma in a dolphin, the first report of three distinct neoplasms in a dolphin, and one of the few reports of malignant neoplasia in dolphins.
  • [MeSH-major] Adrenal Gland Neoplasms / veterinary. Dolphins. Neoplasm Metastasis / pathology. Pheochromocytoma / veterinary. Seminoma / veterinary. Sertoli Cell Tumor / veterinary

  • MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15872383.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


10. Onida GA, Bosincu L, Dessole S, Nicolae A, Preda O, Cossu-Rocca P, Aneiros-Fernandez J, Nogales FF: Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma. Int J Gynecol Pathol; 2010 Sep;29(5):423-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma.
  • The gonadoblastoma on both sides underwent synchronous neoplastic transformation, into a stage I germinoma in the right streak gonad and a highly differentiated Sertoli cell tumor in the left one.
  • The latter was associated with a myriad of microscopic, Sertoli cell implants on the peritoneal surface, which were considered benign as they had a high grade of differentiation, minimal proliferative activity, and an absence of invasion.
  • [MeSH-major] Gonadoblastoma / pathology. Neoplasms, Multiple Primary / pathology. Sertoli Cell Tumor / pathology. Urogenital Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20736766.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


11. Goynumer G, Kayabasoglu F, Senturk B, Turkgeldi E, Guzin K: Acute abdomen due to rupture of Sertoli cell tumor. Arch Gynecol Obstet; 2010 Mar;281(3):557-9
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute abdomen due to rupture of Sertoli cell tumor.
  • PURPOSE: To present a rare case of Sertoli cell tumor that presents with acute abdomen.
  • Frozen pathological study revealed a low-grade sex-cord stromal cell tumor.
  • During 2 years of follow-up, there was no evidence of disease.
  • CONCLUSION: Although rupture of a malignant ovarian tumor is an infrequent cause of acute abdomen, it should be considered in the differential diagnosis of acute abdomen.
  • [MeSH-major] Abdomen, Acute / etiology. Ovarian Neoplasms / complications. Sertoli Cell Tumor / complications

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19597832.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


12. Adayener C, Akyol I, Sen B, Ates F, Haholu A, Soydan H, Karagoz B: Sertoli cell tumor of the testis: a case with late metastasis. Int Urol Nephrol; 2008;40(4):1005-8
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor of the testis: a case with late metastasis.
  • We report on a 20-year-old male who underwent a radical orchidectomy when he was 12 years old which revealed a Sertoli cell tumor in his right testis, and who presented with a 5 x 3 cm retroperitoneal metastatic mass 8 years after orchidectomy.
  • Current experience on Sertoli cell tumor of the testis (SCTT) is insufficient to prognosticate the clinical behavior of the primary tumor on the long term.
  • [MeSH-major] Retroperitoneal Neoplasms / secondary. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18500567.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Hungary
  •  go-up   go-down


13. Jensen KL, Krag L, Boe-Hansen GB, Jensen HE, Lehn-Jensen H: Malignant Sertoli cell tumour in a young Simmenthal bull--clinical and pathological observations. Reprod Domest Anim; 2008 Dec;43(6):760-3
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant Sertoli cell tumour in a young Simmenthal bull--clinical and pathological observations.
  • A case of malignant Sertoli cell tumour in a 29-month-old Simmenthal bull that was hospitalized with a history of severe unilateral scrotal swelling is reported.
  • Histology showed Sertoli cells in tubular structures surrounded by dense fibrous stroma replacing normal testicular tissue.
  • Based on the pathological observations a diagnosis of right-sided malignant Sertoli cell tumour with vascular invasion and hydrocele was established.
  • [MeSH-major] Cattle Diseases / pathology. Sertoli Cell Tumor / veterinary. Testicular Hydrocele / veterinary. Testicular Neoplasms / veterinary
  • [MeSH-minor] Animals. Cattle. Immunohistochemistry / veterinary. Male. Sertoli Cells / pathology

  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18564312.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


14. Werther M, Schmelz HU, Schwerer M, Sparwasser C: [Sclerosing Sertoli cell tumor of the testis: a rare tumor. Case report and review of the literature on the subtypes of Sertoli-cell tumor]. Urologe A; 2007 Nov;46(11):1551-6
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sclerosing Sertoli cell tumor of the testis: a rare tumor. Case report and review of the literature on the subtypes of Sertoli-cell tumor].
  • [Transliterated title] Sklerosierender Sertoli-Zell-Tumor des Hodens - ein seltener Tumor : Fallvorstellung und Literaturübersicht über die Subtypen des Sertoli-Zell-Tumors.
  • Sertoli cell tumors of the testis are extremely rare (0.4-1.5% of all testicular neoplasms) and have a heterogeneous pathology.
  • Histopathologically classic, large cell calcifying and sclerosing subtypes are differentiated.Up to now, 14 cases of sclerosing Sertoli cell tumor are known.
  • While no cases of sclerosing Sertoli cell tumor with a malignant course have been reported, both other subtypes have been found to be potentially malignant.
  • In the case of malignancy the prognosis is very poor, and it is difficult to select the best treatment because there is so little experience with this type of tumor.
  • Once the diagnosis of a Sertoli cell tumor has been confirmed, exact determination of the histological subtype is essential to allow appropriate risk-adapted therapy.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Biopsy. Diagnosis, Differential. Fatty Liver, Alcoholic / blood. Humans. Male. Neoplasm Staging. Sclerosis. Testis / pathology. Ultrasonography. alpha-Fetoproteins

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17898983.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
  • [Number-of-references] 20
  •  go-up   go-down


15. Sato K, Ueda Y, Sakurai A, Ishikawa Y, Okamoto SY, Ikawa H, Katsuda S: Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. Pathol Int; 2005 Jun;55(6):366-71
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor.
  • Large cell calcifying Sertoli cell tumor is a rare type of testicular tumor.
  • Reported herein is a Japanese patient with this tumor not associated with Carney's complex.
  • An 11-year-old boy was admitted to hospital because of left testicular enlargement, and radical orchiectomy was performed.
  • Macroscopically, the tumor was well circumscribed and had a maximum diameter of approximately 2 cm.
  • Histologically, the tumor was composed of large neoplastic cells with abundant eosinophilic cytoplasm with a tubular, trabecular, and solid arrangement and loose myxoid stroma with irregularly shaped calcification.
  • Immunohistochemically, the tumor cells were positive for vimentin, S-100 protein, calretinin, inhibin-alpha, melan-A, and CD10, and type IV collagen and laminin were observed in the extracellular matrix around the tumor cells.
  • The distributions of melan-A, CD10, and mitochondria were characteristically patchy; in contrast, they were diffusely distributed in the cytoplasm in a control case of Leydig cell tumor.
  • The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor.
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm. Calbindin 2. Child. Collagen Type V / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Inhibins / analysis. MART-1 Antigen. Male. Microscopy, Electron. Neoplasm Proteins / analysis. Neprilysin / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Testis / chemistry. Testis / pathology. Testis / ultrastructure. Vimentin / analysis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15943795.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Collagen Type V; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


16. D'Souza L, Burgis JT, Bacon JL, Camps JI: A pure Sertoli cell tumor of the ovary in a 10-year-old female. J Pediatr Adolesc Gynecol; 2007 Aug;20(4):257-9
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A pure Sertoli cell tumor of the ovary in a 10-year-old female.
  • STUDY OBJECTIVE: To document an unusual presentation of a pure Sertoli Cell tumor.
  • Surgical exploration revealed a metastatic pure Sertoli Cell tumor, which was treated with resection and chemotherapy.
  • CONCLUSION: Sertoli cell tumors are rare occurrences and should be considered in the differential diagnosis for a prepubescent girl with an abdominal mass.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sertoli Cell Tumor / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17673140.001).
  • [ISSN] 1083-3188
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


17. Zhao C, Bratthauer GL, Barner R, Vang R: Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases. Am J Surg Pathol; 2007 Feb;31(2):255-66
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases.
  • The main neoplasms in the differential diagnosis for primary ovarian tumors with a tubule-rich pattern are pure Sertoli cell tumor, endometrioid tumors (including borderline tumor, well-differentiated carcinoma, and the sertoliform variant of endometrioid carcinoma), and carcinoid tumor.
  • Because traditional immunohistochemical markers [pan-cytokeratin (pan-CK), low molecular weight cytokeratin (CK8/18), epithelial membrane antigen (EMA), inhibin, calretinin, CD99, chromogranin, and synaptophysin] can occasionally have diagnostic limitations, the goal of this study was to determine whether or not any alternative markers [cytokeratin 7 (CK7), estrogen receptor (ER), progesterone receptor (PR), CD10, and CD56] have better diagnostic utility when compared with traditional markers for this differential diagnosis.
  • Immunohistochemical stains for alternative, as well as traditional, markers were performed on the following primary ovarian tumors: pure Sertoli cell tumor (n = 40), endometrioid borderline tumor (n = 38), sertoliform endometrioid carcinoma (n = 13), well-differentiated endometrioid carcinoma (n = 27), and carcinoid tumor (n = 42).
  • Cytokeratin 7 (CK7) was positive in 97% of endometrioid tumors, 13% of Sertoli cell tumors, and 24% of carcinoid tumors.
  • The differences in the mean ICSs for endometrioid tumors versus Sertoli cell tumor or carcinoid tumor were statistically significant (P values ranging from <0.001 to 0.018).
  • ER and PR were positive in 87% and 86% of endometrioid tumors, 8% and 13% of Sertoli cell tumors, and 2% each of carcinoid tumors, respectively.
  • The differences in the mean ICSs for endometrioid tumors versus Sertoli cell tumor were statistically significant (P values ranging from <0.001 to 0.012).
  • CD10 showed overlapping patterns of expression in all categories of tumors.
  • CD56 showed overlapping patterns of expression in all categories of tumors.
  • When traditional immunohistochemical markers are problematic for the differential diagnosis of ovarian Sertoli cell tumor versus endometrioid tumors versus carcinoid tumor, adding CK7, ER, and/or PR to a panel of markers can be helpful.
  • Endometrioid tumors more frequently express CK7, ER, and PR and show a greater extent of immunostaining in contrast to Sertoli cell tumor and carcinoid tumor.
  • Inhibin is the most discriminatory sex cord marker, and CD10 is not helpful in the differential diagnosis.
  • Chromogranin and synaptophysin are excellent discriminatory markers for carcinoid tumor, and CD56 is neither sufficiently sensitive nor specific enough for this differential diagnosis to warrant its use in routine practice.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoid Tumor / diagnosis. Carcinoma, Endometrioid / diagnosis. Neoplasm Proteins / analysis. Ovarian Neoplasms / diagnosis. Sertoli Cell Tumor / diagnosis
  • [MeSH-minor] Cell Count. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neurosecretory Systems / chemistry


18. Jabbour SA, Davidovici BB, Wolf R: Rare syndromes. Clin Dermatol; 2006 Jul-Aug;24(4):299-316
MedlinePlus Health Information. consumer health - Endocrine Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Some of these endocrine disorders include glucagonoma, neurofibromatosis type 1, McCune-Albright syndrome, multiple endocrine neoplasia, the Carney complex, carcinoid tumors, and mastocytosis.
  • Other presenting features include freckling, peripheral neurofibromas, Lisch nodules, bone abnormalities, tumors, neurologic abnormalities and hypertension.
  • Multiple endocrine neoplasia type 1 is an autosomal dominant predisposition to tumors of the parathyroid glands (four-gland hyperplasia), anterior pituitary, and pancreatic islet cells; hence, the mnemonic device of the "3 Ps"; multiple cutaneous lesions (angiofibromas and collagenomas) are frequent in patients with multiple endocrine neoplasia type 1.
  • Carney complex may be viewed as a form of multiple endocrine neoplasia because affected patients often have tumors of two or more endocrine glands, including primary pigmented nodular adrenocortical disease (some with Cushing's syndrome), pituitary adenoma, testicular neoplasms, thyroid adenoma or carcinoma, and ovarian cysts.
  • Additional unusual manifestations include psammomatous melanotic schwannoma, breast ductal adenoma, and a rare bone tumor, osteochondromyxoma.
  • Carcinoid syndrome is the term applied to a constellation of symptoms mediated by various humoral factors elaborated by some carcinoid tumors; the major manifestations are diarrhea, flushing, bronchospasm, and cardiac valvular lesions.
  • Mast cell diseases include all disorders of mast cell proliferation.
  • These diseases can be limited to the skin, referred to as "cutaneous mastocytosis," or involve extracutaneous tissues, called "systemic mastocytosis."
  • [MeSH-major] Endocrine System Diseases / genetics. Endocrine System Diseases / pathology. Mastocytosis, Cutaneous / pathology. Multiple Endocrine Neoplasia / genetics. Multiple Endocrine Neoplasia / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16828412.001).
  • [ISSN] 0738-081X
  • [Journal-full-title] Clinics in dermatology
  • [ISO-abbreviation] Clin. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 155
  •  go-up   go-down


19. Hes O, Vanecek T, Síma R, Hora M, Velickinová H, Grossmann P, Kovár J, Michal M: [Tumorous diseases in patients with the testicular feminization syndrome ("androgen insensitivity" syndrome)--description of two cases]. Ceska Gynekol; 2005 Mar;70(2):113-7
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumorous diseases in patients with the testicular feminization syndrome ("androgen insensitivity" syndrome)--description of two cases].
  • OBJECTIVE: To describe tumors occurring in two cases of testicular feminization syndrome.
  • SUBJECT AND METHOD: Two cases of testicular feminization syndrome were selected from four cases in our registry.
  • Sertoli cell adenoma was diagnosed in both patients.
  • Older patient had in addition unclassified sex cord tumor of Leydig cell type.
  • CONCLUSION: Patients with testicular feminization syndrome are frequently affected by benign or malignant tumors in the cryptorchid testes.
  • We documented two benign Sertoli cell adenomas and one sex cord tumor of uncertain biological behavior in our patients.
  • The testes should be removed after puberty with subsequent estrogen therapy in patients with testicular feminization syndrome.

  • Genetic Alliance. consumer health - Androgen Insensitivity Syndrome.
  • Genetic Alliance. consumer health - Testicular Feminization.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15918264.001).
  • [ISSN] 1210-7832
  • [Journal-full-title] Ceska gynekologie
  • [ISO-abbreviation] Ceska Gynekol
  • [Language] CZE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
  •  go-up   go-down


20. Culp SJ, Mellick PW, Trotter RW, Greenlees KJ, Kodell RL, Beland FA: Carcinogenicity of malachite green chloride and leucomalachite green in B6C3F1 mice and F344 rats. Food Chem Toxicol; 2006 Aug;44(8):1204-12
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Female rats exposed to malachite green chloride had increased incidences of thyroid gland follicular cell adenoma or carcinoma and hepatocellular adenoma, and a dose-related increasing trend in mammary gland carcinoma.
  • Female rats fed malachite green chloride and female and male rats fed leucomalachite green had a dose-related decreasing trend in the incidence of mononuclear cell leukemia.
  • In male rats fed leucomalachite green there was a decreasing trend in pituitary gland adenoma and an increasing trend in interstitial cell adenoma of the testis.
  • Female mice fed leucomalachite green had a dose-related increasing trend in the incidence of hepatocellular adenoma or carcinoma, with the incidence being significant in the highest dose group.

  • Hazardous Substances Data Bank. Leucomalachite green .
  • Hazardous Substances Data Bank. MALACHITE GREEN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16554117.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Fungicides, Industrial; 0 / Rosaniline Dyes; 12058M7ORO / malachite green; 8U61G37Z20 / leucomalachite green
  •  go-up   go-down


21. Childs-Sanford SE, Rassnick KM, Alcaraz A: Carboplatin for treatment of a Sertoli cell tumor in a mallard (Anas platyrhynchos). Vet Comp Oncol; 2006 Mar;4(1):51-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carboplatin for treatment of a Sertoli cell tumor in a mallard (Anas platyrhynchos).
  • A 13-year-old male mallard was diagnosed with a non-resectable Sertoli cell tumor involving the left testis.
  • The tumor reduced in size by 25%, and the duck's clinical condition improved for 12 months.
  • Sertoli cell tumors are rare in birds, and this is the first report, to our knowledge, of attempted chemotherapy treatment in the veterinary literature.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19754829.001).
  • [ISSN] 1476-5829
  • [Journal-full-title] Veterinary and comparative oncology
  • [ISO-abbreviation] Vet Comp Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


22. Talon I, Moog R, Kauffmann I, Grandadam S, Becmeur F: Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor. J Pediatr Hematol Oncol; 2005 Sep;27(9):491-4
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor.
  • Testis tumors are uncommon in childhood, and they differ from adult tumors in terms of histology and frequency.
  • Sertoli cell tumors appear in children before 1 year of age.
  • In the authors' hospital, of 13 testis tumors diagnosed since 1996, only 2 were Sertoli cell tumors.
  • It would be helpful to have an algorithm for the management of testis tumors, outlining how to make the diagnosis of malignancy and which treatment and follow-up to pursue.
  • [MeSH-major] Algorithms. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16189443.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


23. Jayasena SN, Ariyasinghe JT, Gunawardena DM, Gunawardena SA, de Silva MV: Large-cell calcifying sertoli cell tumour of the testis detected at screening of a family with Carney syndrome. Urol Int; 2005;75(4):365-7
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large-cell calcifying sertoli cell tumour of the testis detected at screening of a family with Carney syndrome.
  • We report the detection of a large-cell calcifying Sertoli cell tumour (LCCSCT) in a 34-year-old male during screening of a family with Carney syndrome.
  • The patient had ignored the testicular swelling for 7 years.
  • [MeSH-major] Calcinosis / pathology. Neoplasms, Multiple Primary / diagnosis. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Genetic Predisposition to Disease. Humans. Male. Middle Aged. Orchiectomy. Risk Factors

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16327308.001).
  • [ISSN] 0042-1138
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


24. Stewart CJ, Baker E, Beaton C, Crook M, Peverall J, Wallace S: Detection of Y-chromosome in gonadal tumours using fluorescence in situ hybridization: diagnostic value in intersex conditions including older patients with clinically unsuspected androgen insensitivity syndrome. Histopathology; 2008 Jan;52(2):175-82
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIMS: To evaluate fluorescence in situ hybridization (FISH) for SRY, the testis-determining gene on the Y-chromosome, in gonadal specimens from patients with intersex disorders including two older individuals presenting with Sertoli cell adenomas and clinically unsuspected androgen insensitivity syndrome (AIS).
  • METHODS AND RESULTS: FISH, using probes for SRY and the X-centromere, was performed on two Sertoli cell adenomas presenting as ovarian masses in phenotypic females aged 62 and 73 years with previously undiagnosed AIS.
  • The specificity of FISH was determined by analysis of 10 sporadic ovarian tumours including six dysgerminomas and four Sertoli-Leydig cell tumours: all cases expressed a female XX chromosomal signal.
  • CONCLUSIONS: The demonstration of SRY using FISH is useful in the assessment of gonadal specimens from patients with intersex disorders, particularly in older individuals where the diagnosis may be unsuspected clinically.
  • [MeSH-major] Adenoma / genetics. Androgen-Insensitivity Syndrome / diagnosis. Chromosomes, Human, Y / genetics. Disorders of Sex Development / diagnosis. In Situ Hybridization, Fluorescence / methods. Ovarian Neoplasms / genetics. Sertoli Cell Tumor / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy. Dysgerminoma / diagnosis. Dysgerminoma / genetics. Dysgerminoma / pathology. Female. Genes, sry / genetics. Gonadoblastoma / diagnosis. Gonadoblastoma / genetics. Gonadoblastoma / pathology. Humans. Male. Middle Aged. Phenotype. Sensitivity and Specificity

  • Genetic Alliance. consumer health - Androgen Insensitivity Syndrome.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18184266.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


25. Blick C, Abdelhadi S, Bailey D, Kelleher J, Muneer A: A unique case of a malignant Sertoli cell tumour with cutaneous metastasis. ScientificWorldJournal; 2008;8:95-7
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A unique case of a malignant Sertoli cell tumour with cutaneous metastasis.
  • Pure Sertoli cell tumours (SCTs) represent less than 1% of testicular neoplasms and malignant forms are rare.
  • We present a unique case of a 69-year-old man who initially underwent inguinal orchidectomy for a malignant SCT.
  • He then subsequently developed a paraumbilical cutaneous lesion which was histologically identical to the primary tumour.
  • [MeSH-major] Sertoli Cell Tumor / pathology. Skin Neoplasms / secondary. Testicular Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18264627.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


26. Mardi K, Sharma J: Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis. Indian J Pathol Microbiol; 2008 Jan-Mar;51(1):70-1
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis.
  • A 9-year-old boy who presented with a left scrotal swelling was subsequently diagnosed as retiform sertoli cell tumor of testis which consisted entirely of retiform pattern.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18417863.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


27. Morelli L, Pusiol T, Piscioli F: [Ovarian oxyphilic Sertoli cell tumor: case report and review of the literature]. Pathologica; 2006 Jun;98(3):184-6
Hazardous Substances Data Bank. HEMATOXYLIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ovarian oxyphilic Sertoli cell tumor: case report and review of the literature].
  • [Transliterated title] Tumore a cellule di Sertoli ossifile dell'ovaio: caso clinico e revisione della letteratura.
  • Ovarian oxyphilic Sertoli cell tumor is a rare neoplasm (only three cases were reported in literature).
  • Pathologist 1 made a diagnosis of endometrioid adenocarcinoma, while Pathologist 2 made the diagnosis of oxyphilic Sertoli cell tumor.
  • He sends the same slides to Pathologist 1, who confirmed his diagnosis.
  • The two different diagnosis set different managements of the lesion for the clinician, but overall they set the pathologist who requested the consultation in a difficult position.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sertoli Cell Tumor / pathology

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17036948.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
  • [Number-of-references] 1
  •  go-up   go-down


28. Teixeira RL, Rossini A, Paim NP: [Testicular tumors in childhood]. Rev Col Bras Cir; 2009 Feb;36(1):85-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Testicular tumors in childhood].
  • Testicular and paratesticular prepuberal tumors are rare.
  • They represent around 1% of the total of tumors of infancy.
  • They subdivide in 2 groups: germ cells tumors and non germ cells tumors, being able to occur in all the ages, and about 75% are malignant, and about 19% of these they present metastasis.
  • The tumors of germ cells tumors represent 60 75% of the tumors testiculars in infancy, having as main example the yolk sac tumor (65% of the neoplasms), followed for teratomas (14%); although some works to exist where teratoma, if presents as most common .The non germ cells tumors include the Leydig cell tumor and Sertoli cell tumor.
  • The Leydig cell tumor, are most frequent between the non germ cells tumors testicular.
  • This review article on epidemiology, diagnosis and treatment of to testicular and to paratesticular tumors in child.
  • [MeSH-major] Testicular Neoplasms
  • [MeSH-minor] Child. Endodermal Sinus Tumor / pathology. Humans. Male. Teratoma / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20076873.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 35
  •  go-up   go-down


29. Zhao C, Bratthauer GL, Barner R, Vang R: Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis. Int J Gynecol Pathol; 2007 Jan;26(1):1-9
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis.
  • The distinction of ovarian Sertoli cell tumor from other tumors in the histological differential diagnosis, particularly endometrioid carcinoma and carcinoid tumor, may be difficult.
  • Many immunohistochemical markers have been studied for this differential diagnosis, but currently available markers are neither 100% sensitive nor specific.
  • Sox9 is a transcription factor involved in Sertoli cell differentiation in the testis.
  • The role that this molecule plays in the pathogenesis of ovarian Sertoli cell tumors and the potential use as an immunohistochemical marker for differential diagnosis have not been investigated.
  • Immunohistochemical staining for Sox9 was performed in 152 ovarian tumors: pure Sertoli cell tumor (n = 36), endometrioid borderline tumor (n = 38), well-differentiated endometrioid carcinoma (n = 26), sertoliform endometrioid carcinoma (n = 13), and carcinoid tumor (n = 39).
  • Sox9 was expressed in 44% of Sertoli cell tumors, 55% of endometrioid borderline tumors, 65% of well-differentiated endometrioid carcinomas, 39% of sertoliform endometrioid carcinomas, and 10% of carcinoid tumors.
  • The mean Sox9 immunohistochemical composite scores in positive cases were 6.3 for Sertoli cell tumor, 5.3 for endometrioid borderline tumor, 8.0 for well-differentiated endometrioid carcinoma, 2.8 for sertoliform endometrioid carcinoma, and 6.8 for carcinoid tumor.
  • The differences in the mean Sox9 composite scores between Sertoli cell tumor and the other tumor categories were not statistically significant (p values ranged from 0.092 to 0.523).
  • We conclude that Sox9 is variably expressed in ovarian Sertoli cell tumor and other tumors that are in the differential diagnosis and, thus, is not helpful for immunohistochemical distinction.
  • Understanding the role of Sox9 in the pathogenesis of ovarian Sertoli cell tumor requires further study.
  • [MeSH-major] High Mobility Group Proteins / analysis. High Mobility Group Proteins / metabolism. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / metabolism. Sertoli Cell Tumor / diagnosis. Sertoli Cell Tumor / metabolism. Transcription Factors / analysis. Transcription Factors / metabolism
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / metabolism. Cell Differentiation. Diagnosis, Differential. Female. Humans. Immunohistochemistry. SOX9 Transcription Factor

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17197889.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / High Mobility Group Proteins; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / Transcription Factors
  •  go-up   go-down


30. Zhao C, Bratthauer GL, Barner R, Vang R: Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. Am J Surg Pathol; 2007 Sep;31(9):1378-86
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.
  • WT1, the Wilms tumor gene product, can be expressed in various tumors from different anatomic sites, including some types of ovarian tumors.
  • Regarding the latter, most studies have focused on surface epithelial-stromal tumors in which serous carcinomas are usually positive and endometrioid carcinomas are negative.
  • Very few studies have specifically investigated this marker in ovarian sex cord-stromal tumors; however, limited data in the literature suggest that WT1 may be frequently expressed in sex cord-stromal tumors.
  • As pure Sertoli cell tumor can be in the histologic differential diagnosis of endometrioid tumors (particularly borderline tumor and carcinoma) and carcinoid, immunostaining for WT1 might be of diagnostic value.
  • Immunohistochemical staining for WT1 was performed in 108 ovarian tumors: pure Sertoli cell tumor (n=26), endometrioid borderline tumor (n=25), classic well-differentiated endometrioid carcinoma (n=23), sertoliform endometrioid carcinoma (n=12), and carcinoid (n=22).
  • Additionally, inhibin and calretinin immunostaining were performed in all cases of Sertoli cell tumor for purposes of comparing expression with WT1.
  • Nuclear expression of WT1 was present in 96% of Sertoli cell tumors, 16% of endometrioid borderline tumors, 13% of classic well-differentiated endometrioid carcinomas, 25% of sertoliform endometrioid carcinomas, and 0% of carcinoids.
  • In Sertoli cell tumors, expression was diffuse (>50% of positive cells) in all positive cases.
  • When positive in the non-Sertoli cell tumors, the extent of expression tended to be focal to patchy (50% or less positive cells).
  • In Sertoli cell tumors, inhibin and calretinin were expressed in 96% and 54% of cases, respectively.
  • Coordinate patterns for the extent of expression of WT1, inhibin, and calretinin in pure Sertoli cell tumor showed that all 3 markers were positive in 54% of cases; however, 42% were positive for WT1 and inhibin but negative for calretinin.
  • We conclude that ovarian Sertoli cell tumor should be added to the growing list of WT1-positive tumors.
  • This marker is useful for the distinction of Sertoli cell tumor from endometrioid tumors and carcinoid.
  • The diagnostic utility of WT1 in Sertoli cell tumor is similar to inhibin but better than that of calretinin.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoid Tumor / diagnosis. Carcinoma, Endometrioid / diagnosis. Immunohistochemistry. Ovarian Neoplasms / diagnosis. Sertoli Cell Tumor / diagnosis. WT1 Proteins / analysis
  • [MeSH-minor] Calbindin 2. Cell Differentiation. Diagnosis, Differential. Female. Humans. Inhibins / analysis. Predictive Value of Tests. Reproducibility of Results. S100 Calcium Binding Protein G / analysis

  • MedlinePlus Health Information. consumer health - Carcinoid Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17721194.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / WT1 Proteins; 57285-09-3 / Inhibins
  •  go-up   go-down


31. Azurmendi Arín I, Llarena Ibarguren R, Rodríguez JG, Olano Grasa I, Cantón Aller E, Pertusa Peña C: [Sertoli cell malignant tumor]. Arch Esp Urol; 2008 Sep;61(7):834-7
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sertoli cell malignant tumor].
  • [Transliterated title] Tumor de células de Sertoli maligno.
  • OBJECTIVE: We report a new case of Sertoli cell testicular tumor with malignant characteristics.
  • METHODS: 77 year-old male patient, suffering a general wasting syndrome presenting with a left solid testicular mass with the diagnosis of malignant Sertoli cell tumor after orchyectomy, without local, regional or distant dissemination, and a benign outcome after 18 months of follow-up.
  • RESULTS: Sertoli cell tumor or androblastoma is classified as non-germ cell tumor derived from the stroma of the sexual cords.
  • There are three types depending on its cellular composition: calcified big cell, sclerotic cell, and the most frequent of all, the classic type.
  • CONCLUSIONS: Being the Sertoli cell testicular tumor rare, its malignant type is even rarer, accounting for not more than 10% of all.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18972923.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


32. Coelho R, Brito MJ, Casella P, Bragança G, Machado MC: [Microlithiasis and testicular tumour]. Acta Med Port; 2005 Nov-Dec;18(6):485-7
MedlinePlus Health Information. consumer health - Testicular Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microlithiasis and testicular tumour].
  • [Transliterated title] Microlitíase e tumor testicular.
  • Testicular microlithiasis is a rare entity, usually asymptomatic and bilateral.
  • There are however reports that until 40% of the cases may be related with testicular tumours.
  • We report an 11-year-old boy, with a four-month history of left testicular mass.
  • Sonography showed increased volume of left testis and bilateral microlithiasis.
  • Testicular biopsy revealed Sertoli cell tumour and he was submitted to left radical orquidectomy.
  • Testicular cancer is often curable, especially if diagnosed and treated early.
  • The association of malignancy justifies long term clinical and ultrasound follow-up of testicular microlithiasis.
  • [MeSH-major] Calculi / complications. Sertoli Cell Tumor / complications. Testicular Diseases / complications. Testicular Neoplasms / complications

  • Genetic Alliance. consumer health - Testicular microlithiasis.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16684490.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
  •  go-up   go-down


33. Demidov VN, Lipatenkova J, Vikhareva O, Van Holsbeke C, Timmerman D, Valentin L: Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol; 2008 Jan;31(1):85-91
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors.
  • OBJECTIVE: To describe the clinical history and ultrasound findings in women with ovarian Sertoli cell, Sertoli-Leydig cell and Leydig cell tumors.
  • METHODS: Women with a histological diagnosis of Sertoli cell tumor, Sertoli-Leydig cell tumor or Leydig cell tumor who had undergone preoperative ultrasound examination were identified from the databases of each of three participating ultrasound centers.
  • The tumors were characterized on the basis of ultrasound images, ultrasound reports and research protocols (when applicable) using the terms and definitions published by the International Ovarian Tumor Analysis (IOTA) group.
  • RESULTS: Of 22 patients identified, 15 had Sertoli-Leydig cell tumors, two had Sertoli cell tumors and five had Leydig cell tumors.
  • Twenty-two (96%) of 23 tumors (one woman had bilateral tumors) contained a solid component; 16 (70%) were purely solid.
  • Pattern recognition showed that the Leydig cell tumors were small solid tumors (four of five had a largest diameter of 1-3 cm) and the two Sertoli cell tumors were somewhat larger solid tumors (4 cm and 7 cm); the Sertoli-Leydig cell tumors were either small (3-4 cm) or medium-sized (6-7 cm) solid tumors, or multilocular solid tumors of any size (3-18 cm) with purely solid areas mixed with areas of innumerable closely packed small cyst locules.
  • CONCLUSIONS: On the basis of endocrine symptoms, the woman's age and ultrasound findings, it should be possible to suggest a correct preoperative diagnosis of Sertoli cell, Sertoli-Leydig cell or Leydig cell tumors in many cases.
  • [MeSH-major] Ovarian Neoplasms / ultrasonography. Sertoli-Leydig Cell Tumor / ultrasonography
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Differentiation / physiology. Female. Humans. Middle Aged. Pattern Recognition, Automated / methods. Prognosis

  • Genetic Alliance. consumer health - Sertoli-leydig cell tumors.
  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2007 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 18098335.001).
  • [ISSN] 0960-7692
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


34. Zhao C, Barner R, Vinh TN, McManus K, Dabbs D, Vang R: SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor. Int J Gynecol Pathol; 2008 Oct;27(4):507-14
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor.
  • Immunohistochemistry can be an important part of the diagnosis of Sertoli cell tumor of the ovary, including distinction from non-sex cord-stromal tumors such as the sertoliform variant of endometrioid carcinoma and carcinoid.
  • Several good markers for this differential diagnosis have been identified, particularly inhibin, Wilms tumor 1 gene product (WT1), epithelial membrane antigen, and chromogranin; however, many available markers have limitations to some degree.
  • In the testes, SF-1 is expressed in Sertoli cells.
  • Immunohistochemical expression of this marker in ovarian sex cord-stromal tumors, including utility for differential diagnosis, has not been rigorously evaluated.
  • As an extension of our previous immunohistochemical studies of ovarian Sertoli cell tumor, expression of SF-1 and comparison with WT1 and inhibin were assessed in 111 primary ovarian tumors: 27 Sertoli cell tumors, 60 endometrioid tumors (including borderline tumors, conventional well-differentiated carcinomas, and sertoliform variants of carcinoma), and 24 carcinoids.
  • SF-1 was expressed in 100% of Sertoli cell tumors but not in endometrioid tumors or carcinoid.
  • WT1 was expressed in 100% of Sertoli cell tumors and 17% of endometrioid tumors; all carcinoids were negative.
  • Inhibin was expressed in 96% of Sertoli cell tumors and 2% of endometrioid tumors (4% of conventional well-differentiated carcinomas); all carcinoids were negative.
  • The extent of expression of all 3 markers was similar in Sertoli cell tumor but greatest for WT1: 63%, 96%, and 78% of cases showed expression of SF-1, WT1, and inhibin, respectively, in more than 50% of tumor cells.
  • Immunohistochemical composite scores combining both extent and intensity of staining in positive cases were calculated for Sertoli cell tumor (possible range: 1-12).
  • We conclude that for the differential diagnosis with endometrioid tumors and carcinoid of the ovary, SF-1 is a sensitive and specific immunohistochemical marker for Sertoli cell tumor and that SF-1 is diagnostically comparable with other good sex cord-stromal markers.
  • [MeSH-major] Carcinoma, Endometrioid / diagnosis. Ovarian Neoplasms / diagnosis. Sertoli Cell Tumor / diagnosis. Steroidogenic Factor 1 / analysis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Inhibins / analysis. Nuclear Proteins / analysis. Retrospective Studies

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18753972.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Steroidogenic Factor 1; 0 / WTAP protein, human; 57285-09-3 / Inhibins
  •  go-up   go-down


35. Teankum K, Hauser B, Grest P, Pospischil A, Janett F, Bürgi E, Borel N: Capillary haemangiomas of the scrotum and testicle in boars. J Comp Pathol; 2008 Nov;139(4):177-86
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of 12 boars with scrotal haemangiomas, three animals also had testicular tumours, as follow: testicular haemangioma (TH) (n=1); TH with intratubular germ cell tumour (ITGT) (n=1); TH with intratubular germ cell-like tumour (ITGLT) and Sertoli cell tumour (n=1).
  • In the nine remaining boars, no testicular tumours were found.
  • Immunohistochemical examination of scrotal and testicular haemangiomas revealed labelling of endothelial cells for vimentin and factor VIII-related antigen.
  • The Sertoli cell tumour was strongly positive for S-100.
  • [MeSH-major] Hemangioma, Capillary / pathology. Hemangioma, Capillary / veterinary. Scrotum / pathology. Swine Diseases / pathology. Testicular Neoplasms / pathology. Testicular Neoplasms / veterinary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18775543.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  •  go-up   go-down


36. Massa G, Roggen N, Renard M, Gille JJ: Germline mutation in the STK11 gene in a girl with an ovarian Sertoli cell tumour. Eur J Pediatr; 2007 Oct;166(10):1083-5
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germline mutation in the STK11 gene in a girl with an ovarian Sertoli cell tumour.
  • INTRODUCTION: An ovarian Sertoli cell tumour was detected in a 4-year-old girl with gonadotrophin-independent precocious puberty.
  • The mutation was heterozygous in patient's lymphocytes and almost homozygous in the tumour, indicating loss of heterozygosity.
  • CONCLUSION: This is the first report of a STK11 germline mutation in a girl with an ovarian Sertoli cell tumour.
  • [MeSH-major] Codon, Nonsense. Ovarian Neoplasms / genetics. Protein-Serine-Threonine Kinases / genetics. Puberty, Precocious / genetics. Sertoli Cell Tumor / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17124587.001).
  • [ISSN] 0340-6199
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Codon, Nonsense; 33515-09-2 / Gonadotropin-Releasing Hormone; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  •  go-up   go-down


37. Iwamoto I, Yanazume S, Fujino T, Yoshioka T, Douchi T: Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol; 2005 Mar;96(3):870-2
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome.
  • Testicular tumors often develop in patients with AIS, Sertoli cell tumor and seminoma being the most common types.
  • Leydig cell tumor in AIS is extremely rare.
  • CASE: A large abdominal tumor developed in a 73-year-old female patient.
  • The patient underwent the extirpation of bilateral gonads including the tumor, pelvic lymph nodes, omentum and appendix vermiformis.
  • The pathological diagnosis was malignant Leydig cell tumor of the left testis.
  • The patient showed no evidence of disease at the post-operative 1 month checkup.
  • CONCLUSION: We reported an extremely rare case of malignant Leydig cell tumor developing in an elderly AIS patient.
  • [MeSH-major] Androgen-Insensitivity Syndrome / complications. Leydig Cell Tumor / complications. Ovarian Neoplasms / complications


38. Chang H, Guillou F, Taketo MM, Behringer RR: Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. Biol Reprod; 2009 Nov;81(5):842-9
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse.
  • Mice with mutations that result in overactive WNT/beta-catenin signaling developed tumors in some tissues, such as digestive tract, skin, and ovary, but they failed to develop tumors in other tissues, such as mammary gland, liver, kidney, and primordial germ cells.
  • To investigate whether overactive beta-catenin signaling is capable of inducing Sertoli cell tumorigenesis in testes, we generated Ctnnb1(tm1Mmt/+);Tg(AMH-cre)1Flor male mice that express a constitutively active form of beta-catenin specifically in Sertoli cells.
  • No tumors were observed at 4 mo of age, but 70% of the mutant males developed Sertoli cell tumors at 8 mo of age.
  • At 1 yr of age, more than 90% of the mutant males developed tumors.
  • No instances of extratesticular spread of the tumors were found in the mutant mice.
  • These studies show a causal link between overactive WNT/beta-catenin signaling and Sertoli cell tumor development and provide a novel mouse model for the study of Sertoli cell tumor biology.

  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • COS Scholar Universe. author profiles.
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Science. 2000 Mar 3;287(5458):1606-9 [10733430.001]
  • [Cites] Development. 2008 May;135(10):1875-85 [18403409.001]
  • [Cites] Urol Res. 2001 Jun;29(3):144-51 [11482437.001]
  • [Cites] Oncogene. 2001 Sep 20;20(42):5972-81 [11593404.001]
  • [Cites] Cancer Res. 2001 Nov 15;61(22):8247-55 [11719457.001]
  • [Cites] Cancer Res. 2002 Apr 1;62(7):1971-7 [11929813.001]
  • [Cites] Am J Surg Pathol. 2002 May;26(5):541-50 [11979085.001]
  • [Cites] Oncogene. 2002 Jun 13;21(26):4099-107 [12037666.001]
  • [Cites] Genesis. 2002 Jul;33(3):114-8 [12124943.001]
  • [Cites] Biol Reprod. 2008 Sep;79(3):475-85 [18480464.001]
  • [Cites] Bioessays. 1999 Dec;21(12):1021-30 [10580987.001]
  • [Cites] EMBO J. 1999 Nov 1;18(21):5931-42 [10545105.001]
  • [Cites] Mol Biol Cell. 2000 Oct;11(10):3509-23 [11029052.001]
  • [Cites] Biochim Biophys Acta. 2003 Jun 5;1653(1):1-24 [12781368.001]
  • [Cites] Dev Biol. 2003 Jun 15;258(2):406-18 [12798297.001]
  • [Cites] Oncogene. 2003 Jun 19;22(25):3875-87 [12813461.001]
  • [Cites] Mol Biol Cell. 2003 Jul;14(7):2844-60 [12857869.001]
  • [Cites] Genes Dev. 2004 May 1;18(9):1072-87 [15132997.001]
  • [Cites] Recent Results Cancer Res. 1977;(60):176-95 [194290.001]
  • [Cites] Biol Reprod. 1979 Apr;20(3):409-22 [36931.001]
  • [Cites] Endocrinology. 1986 Oct;119(4):1641-7 [2944738.001]
  • [Cites] Proc Natl Acad Sci U S A. 1987 Jul;84(14):5082-6 [3474640.001]
  • [Cites] Science. 1990 Jan 19;247(4940):322-4 [2296722.001]
  • [Cites] Am J Anat. 1990 May;188(1):3-20 [2161173.001]
  • [Cites] Mol Endocrinol. 1992 Sep;6(9):1403-11 [1331774.001]
  • [Cites] Nature. 1992 Nov 26;360(6402):313-9 [1448148.001]
  • [Cites] Cancer Res. 1996 Jul 15;56(14):3320-3 [8764128.001]
  • [Cites] Science. 1997 Mar 21;275(5307):1790-2 [9065403.001]
  • [Cites] EMBO J. 1997 Jul 1;16(13):3797-804 [9233789.001]
  • [Cites] Cancer Res. 1998 Apr 1;58(7):1344-7 [9537226.001]
  • [Cites] Am J Surg Pathol. 1998 Jun;22(6):709-21 [9630178.001]
  • [Cites] Science. 1998 Sep 4;281(5382):1509-12 [9727977.001]
  • [Cites] Cell. 1998 Nov 25;95(5):605-14 [9845363.001]
  • [Cites] Cancer Res. 1999 Jan 15;59(2):269-73 [9927029.001]
  • [Cites] Am J Pathol. 1999 Feb;154(2):325-9 [10027390.001]
  • [Cites] Nature. 1999 Apr 1;398(6726):422-6 [10201372.001]
  • [Cites] Cancer Res. 1999 Aug 15;59(16):3875-9 [10463573.001]
  • [Cites] Cancer Res. 1999 Aug 15;59(16):3880-2 [10463574.001]
  • [Cites] Cancer Res. 2005 Oct 15;65(20):9206-15 [16230381.001]
  • [Cites] Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92 [16877546.001]
  • [Cites] Dev Biol. 2006 Dec 15;300(2):545-53 [17055474.001]
  • [Cites] Mol Cell Biol. 2008 Jan;28(1):248-57 [17967875.001]
  • [ErratumIn] Biol Reprod. 2010 Apr;82(4):803
  • (PMID = 19553598.001).
  • [ISSN] 1529-7268
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / HD30284; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / CA16672; United States / NICHD NIH HHS / HD / R37 HD030284; United States / NICHD NIH HHS / HD / R01 HD030284
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / beta Catenin
  • [Other-IDs] NLM/ PMC2770017
  •  go-up   go-down


39. Hummel M, Schaaf L, Füchtenbusch M, Standl E, Ziegler A: [62 year-old patient with rapid progressive edema, low potassium and hypertension]. Internist (Berl); 2006 Apr;47(4):427, 429-33
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary neoplasm is a small cell cancer.
  • A Sertoli-cell-tumor of the testis was diagnosed as an additional carcinoma.
  • [MeSH-major] Cushing Syndrome / etiology. Edema / etiology. Hypertension / etiology. Hypokalemia / etiology. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Humans. Male. Middle Aged


40. Kara C, Kutlu AO, Tosun MS, Apaydin S, Senel F: Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. Horm Res; 2005;63(5):252-6
Hazardous Substances Data Bank. TESTOLACTONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • Sertoli cell tumors in boys with PJS have been increasingly recognized as a cause of prepubertal gynecomastia.
  • We report on a 7.25-year-old boy with PJS, bilateral gynecomastia, Sertoli cell tumor and nephrocalcinosis, and present the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • The patient presented with bilateral breast and testis enlargement, and mucocutaneous pigmentation.
  • Testicular ultrasound revealed parenchymal multiple microcalcifications.
  • Histopathological examination was consistent with Sertoli cell tumors.
  • [MeSH-major] Aromatase Inhibitors / therapeutic use. Gynecomastia / complications. Peutz-Jeghers Syndrome / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testolactone / therapeutic use

  • Genetic Alliance. consumer health - Peutz Jeghers syndrome.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15947469.001).
  • [ISSN] 0301-0163
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 6J9BLA949Q / Testolactone
  •  go-up   go-down


41. Gómez García I, Romero Molina M, López-García Moreno A, Buendía González E, Rubio Hidalgo E, Bolufer E, Sampietro Crespo A, Gómez Rodríguez A: Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. Arch Esp Urol; 2010 Jun;63(5):392-5
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature.
  • OBJECTIVE: We report two new cases of Sertoli cell testicular tumors, and a Cochrane and Medline search of cases published worldwide.
  • METHODS: We reviewed our series of testicular tumors, the stromal tumor incidence, clinical presentation, treatment and prognosis, and the experience reflected in the literature.
  • RESULTS: The prevalence of testicular tumors in our health area is of 0.09%, and 2.3% of them are Sertoli cell neoplasms.
  • This figure is slightly higher than the found in other series in which Sertoli tumors range from 0.4% to 1.5% of testicular malignancies in adults and reach 4% in children.
  • CONCLUSIONS: Sertoli cell tumor has an incidence not exceeding 4%.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20587845.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  •  go-up   go-down


42. Sassa N, Yoshino Y, Matsukawa Y, Komatsu T, Yoshikawa Y, Yamamoto T, Hattori R, Gotoh M: [Case report of malignant sertoli cell tumor]. Nihon Hinyokika Gakkai Zasshi; 2008 Jul;99(5):656-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case report of malignant sertoli cell tumor].
  • Malignant sertoli cell tumor is a rare disease and only a few cases have been described previously.
  • We report a terminal case of malignant sertoli cell tumor.
  • A 38-year-old male visited a hospital with a complaint of swelling his left testis.
  • His pathologic diagnosis was suspected seminoma, and all tumor markers (LDH, HCG, AFP) were negative, and CT imaging confirmed clinical stage 1 (pT1N0M0S0).
  • After he underwent a CT guided lymph node biopsy, his pathologic diagnosis was viable embryonal carcinoma.
  • His pathologic diagnosis was viable sertoli cell tumor, malignant type.
  • All tumor markers were negative in his all clinical courses.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Combined Modality Therapy. Fatal Outcome. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Orchiectomy. Organoplatinum Compounds / administration & dosage. Salvage Therapy. Tomography, X-Ray Computed

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18697473.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; 7673326042 / irinotecan; 8UQ3W6JXAN / nedaplatin; XT3Z54Z28A / Camptothecin
  •  go-up   go-down


43. Kim O, Kim KS: Seminoma with hyperesterogenemia in a Yorkshire Terrier. J Vet Med Sci; 2005 Jan;67(1):121-3
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We thought that hyperesterogenemia and alopecia in this case was probably related with his seminoma, although high correlations between Sertoli cell tumor and alopecia have been reported.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15699609.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogens
  •  go-up   go-down


44. Petersson F, Bulimbasic S, Sima R, Michal M, Hora M, Malagon HD, Matoska J, Hes O: Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. Hum Pathol; 2010 Apr;41(4):552-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene.
  • Four cases of large cell calcifying Sertoli cell tumor, 3 benign and 1 malignant, with no clinical signs of Carney complex or Peutz-Jeghers syndrome are reported with results of histologic, immunohistochemical, ultrastructural, and comparative genomic hybridization studies.
  • The patient with a malignant large cell calcifying Sertoli cell tumor died of disease 4 years after surgery.
  • Patients with benign tumors have had an uneventful follow-up for 1 and 3 years.
  • All tumors were well circumscribed, unencapsulated, and composed of solid sheets, irregular cords, tubular structures, and nests in a fibrous and/or myxoid stroma with cellular atypia in the malignant case.
  • All tumors showed diffuse immunoreactivity for inhibin, vimentin, calretinin, and S100 protein.
  • Tumors were negative for CAM 5.2, Mic-2, Melan-A laminin, placental alkaline phosphatase, and alpha-fetoprotein.
  • The proliferation index was 5% and 10% for 2 of the benign tumors and 30% for the malignant tumor.
  • Although the combination of large cell calcifying Sertoli cell tumor and PRKAR1A mutation fulfills the criteria for establishing a diagnosis of Carney complex, the clinical relevance of finding a PRKAR1A gene mutation in a patient without any clinical signs of Carney complex or Peutz-Jeghers syndrome remains to be established.
  • [MeSH-major] Cyclic AMP-Dependent Protein Kinase RIalpha Subunit / metabolism. Sertoli Cell Tumor / metabolism. Testicular Neoplasms / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 Elsevier Inc.
  • (PMID = 20004940.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / PRKAR1A protein, human
  •  go-up   go-down


45. Young RH: Testicular tumors--some new and a few perennial problems. Arch Pathol Lab Med; 2008 Apr;132(4):548-64
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular tumors--some new and a few perennial problems.
  • The histopathology of testicular tumors is presented, emphasizing new, unusual, or underemphasized aspects.
  • Within the category of seminoma of the usual type, the recent literature has drawn attention to the presence in occasional tumors of solid or hollow tubules or spaces of varying sizes and shape that may result in cribriform or microcystic patterns, causing potential confusion with other neoplasms, most notably Sertoli cell tumor or yolk sac tumor.
  • Although regions of typical neoplasia and awareness of this phenomenon usually will be diagnostic, immunohistochemistry may play a role in excluding Sertoli cell tumor or yolk sac tumor.
  • Although immunohistochemistry can play an undoubted helpful role in this and selected other areas of testicular tumor evaluation, careful evaluation of the gross and routine microscopic features will solve the vast majority of diagnostic problems.
  • Spermatocytic seminoma remains a crucial pitfall in diagnosis, and the pathologist must always be alert to the possible diagnosis when looking at a seminomatous neoplasm, particularly in an older patient, although about one third of these tumors occur in the usual seminoma age range.
  • The enigmatic and picturesque tumor, polyembryoma, which virtually never occurs in pure form but may be a confusing component of a variety of mixed germ cell tumors, is discussed and illustrated.
  • The phenomenon of burnt-out germ cell neoplasia is also briefly noted and an excellent recent contribution is referred to.
  • Within the sex cord-stromal family of neoplasms, recent contributions and elaborations of unusual morphologic features of Leydig cell tumors and Sertoli cell tumors are presented.
  • Within the Leydig cell family, cyst formation, adipose metaplasia, calcification or ossification, and spindle cell patterns may be particularly confusing, and in the Sertoli cell family, a great array of patterns caused by differing admixtures of tubular, solid, and stromal components occur.
  • The peculiar lesion, intratubular large cell hyalinizing Sertoli cell tumor, of young boys with Peutz-Jeghers syndrome, is briefly discussed.
  • Some of the problems in the family of hematopoietic neoplasms are reviewed, these processes posing diverse problems in differential diagnosis and their correct recognition having crucial therapeutic implications.
  • Although secondary tumors to the testis have not received the same attention in the literature as the similar phenomenon in the female gonad, remarkable examples of testicular spread of diverse neoplasms, usually carcinoma but rarely melanoma, are seen, and the pathologist should be alert to this possibility, particularly when examining an unusual morphology in an older patient.
  • Finally, a few comments are made on the common paratesticular neoplasm, the adenomatoid tumor, highlighting its varied patterns and recent description of some of the issues that may arise when they undergo total or subtotal infarction.
  • [MeSH-major] Pathology / education. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / pathology. Diagnosis, Differential. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Humans. Male. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / pathology. Seminoma / diagnosis. Seminoma / pathology. Teratoma / diagnosis. Teratoma / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18384207.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
  •  go-up   go-down


46. Ichimura R, Shibutani M, Mizukami S, Suzuki T, Shimada Y, Mitsumori K: A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch. J Vet Med Sci; 2010 Feb;72(2):229-34
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch.
  • We report a rare case of benign sex cord-stromal tumor consisted largely of luteoma with minor portion of Sertoli cell tumor located at the position of the left ovary excision in an 11-year-old ovariectomized bitch.
  • Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin alpha and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically.
  • The results suggest that this tumor is a possible complication of incomplete ovarian excision at the time of ovariectomy and consisted of uncommon hybrid of luteal and Sertoli cells to be diagnosed as an unclassified sex cord-stromal tumor if applied in human cases.
  • WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19940389.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


47. Zhao YC, Shi QL, Zhou XJ, Ma HH, Lu ZF, Zhou HB: [Clinicopathological study of primary carcinoid tumor of the testis]. Zhonghua Nan Ke Xue; 2007 Feb;13(2):157-60
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathological study of primary carcinoid tumor of the testis].
  • OBJECTIVE: To study the clinicopathological characteristics, immunohistochemical features and histogenesis of primary testicular carcinoid tumor and its differential diagnosis.
  • METHODS: Light microscopy and immunohistochemical stains were performed in 4 cases of primary testicular carcinoid tumor.
  • RESULTS: The patients sought care for scrotum mass presented from 2 to 36 years, 2 cases accompanied with tender swelling of the testis.
  • The tumors were described as nodular, yellowish-gray in color, 3.0-4.0 cm in the greatest dimensions, and well circumscribed, focal necrosis seen in 1 case.
  • The tumor cells were round or polygonal with regular monomorphic nuclei, stippling chromatin and eosinophilic granular cytoplasm.
  • Immunohistochemical staining for synaptophysin, chromogranin A, NSE and cytokeratin showed diffusely positive expression in the tumor cells.
  • CONCLUSION: Primary testicular carcinoid tumor is extremely rare with good prognosis and its histogenesis remains controversial.
  • Diagnostically it has to be differentiated from seminoma, metastatic carcinoid tumor, Sertoli cell tumor and granulosa cell tumor.
  • [MeSH-major] Carcinoid Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Granulosa Cell Tumor / pathology. Humans. Male. Neoplasm Metastasis. Seminoma / pathology. Sertoli Cell Tumor / pathology

  • Genetic Alliance. consumer health - Carcinoid Tumor.
  • MedlinePlus Health Information. consumer health - Carcinoid Tumors.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17345775.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


48. Jarzembowski JA, Lieberman RW: Pediatric sex cord-stromal tumor with composite morphology: a case report. Pediatr Dev Pathol; 2005 Nov-Dec;8(6):680-4
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pediatric sex cord-stromal tumor with composite morphology: a case report.
  • Histologically, the tumor exhibited several different morphologic appearances including adult granulosa cell tumor, juvenile granulosa cell tumor (with areas of marked atypia), and Sertoli cell tumor.
  • Immunohistochemically, the tumor was positive for calretinin, MIC-2 (CD99), S100 protein, PGP 9.5, and neuron-specific enolase.
  • Electron microscopy of the Sertoli cell tumor-like areas showed Charcot-Bottcher filaments, a distinguishing feature of Sertoli cells.
  • Together, these findings supported a diagnosis of mixed sex cord-stromal tumor including granulosa cell tumor of adult and juvenile types and intermediate- to high-grade Sertoli cell tumor, with large areas of markedly atypical sex cord-stromal tumor.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology
  • [MeSH-minor] Carcinoma, Small Cell / pathology. Child. Developmental Disabilities / complications. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Intellectual Disability / complications. Lymphoma / pathology. Microscopy, Electron, Transmission. Neuroectodermal Tumors, Primitive / pathology. Rhabdomyosarcoma / pathology. Sarcoma, Ewing / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16222477.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


49. Kos M, Nogales FF, Kos M, Stipoljev F, Kunjko K: Congenital juvenile granulosa cell tumor of the testis in a fetus showing full 69,XXY triploidy. Int J Surg Pathol; 2005 Apr;13(2):219-21
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital juvenile granulosa cell tumor of the testis in a fetus showing full 69,XXY triploidy.
  • Testicular juvenile granulosa cell tumor (TJGCT) occurs predominantly in infancy and may be associated with sex chromosomal abnormalities.
  • The tumor presented as an abdominal multicystic mass with typical histologic and immunohistological features of JGCT.
  • It was connected with a tubular uterus-like structure.
  • The other gonad was an inguinally localized testis that showed histologically a Sertoli cell adenoma.
  • [MeSH-major] Disorders of Sex Development / pathology. Fetus / abnormalities. Granulosa Cell Tumor / pathology. Polyploidy. Testicular Neoplasms / pathology
  • [MeSH-minor] Abortion, Eugenic. Biomarkers, Tumor / metabolism. Female. Gonadal Dysgenesis. Humans. Immunoenzyme Techniques. Karyotyping. Male

  • Genetic Alliance. consumer health - Triploidy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15864389.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


50. Haddad O, Leroy X, Lemaitre L, Biserte J, Rigot JM: [Infertility and testicular tumour based on a series of 25 patients]. Prog Urol; 2005 Dec;15(6):1096-100
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Infertility and testicular tumour based on a series of 25 patients].
  • [Transliterated title] Infertilité et tumeur du testicule: a propos de 25 patients.
  • OBJECTIVES: To evaluate the frequency of testicular tumours in infertile men and to specify their clinical, ultrasound and histological characteristics.
  • RESULTS: Twenty-six testicular tumours were operated in 25 patients, i.e.
  • Histological examination demonstrated 15 Leydig cell tumours (58%), 8 seminomas (30%), mature teratoma,1 Sertoli cell tumour, and 1 burnt-out tumour.
  • Tumour markers were normal in 24 of the 25 patients (96%).
  • CONCLUSION: The incidence of testicular tumours in infertile men is much higher than in the general population.
  • [MeSH-major] Infertility, Male / etiology. Testicular Neoplasms / complications

  • Genetic Alliance. consumer health - infertility.
  • MedlinePlus Health Information. consumer health - Male Infertility.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16429659.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


51. Ding XL, Sun AJ, Zhou YZ, Tian QJ, Yu Q, He FF, Shen K, Lang JH: [Identification of potential neoplastic risk in gonadal development abnormality with Y chromosome of 79 cases]. Zhonghua Fu Chan Ke Za Zhi; 2008 Jun;43(6):442-4
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Identification of potential neoplastic risk in gonadal development abnormality with Y chromosome of 79 cases].
  • OBJECTIVE: To identify the potential neoplastic risk in gonadal development abnormality with Y chromosome.
  • RESULTS: Among 41 cases of androgen insensitive syndrome, spermatogenic cell neoplasm occurred in 1 patient, sertoli cell tumor in 2, and interstitial cell hyperplasia in 5.
  • Among 14 cases of 17 alpha-hydroxylase deficiency (XY) syndrome, one was sertoli cell tumor, and one was sertoli cell hyperplasia.
  • One of 16 cases of XO/XY gonadal dysgenesis was spermatogenic cell neoplasm with agenda cell tumor.
  • All of the gonadoblastoma and germ-cell tumor were located in the pelvis.
  • Tumors occurred mostly during 15 years of age to 32 years.
  • CONCLUSIONS: The gonads of XY pure gonadal dysgenesis has high risks of gonadoblastoma and germ-cell tumor.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19035140.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


52. Yearley JH, King N, Liu X, Curran EH, O'Neil SP: Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. Vet Pathol; 2008 Nov;45(6):922-7
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature.
  • The animal was castrated, and histologic examination revealed a biphasic sex cord-stromal tumor, with one region resembling Sertoli-cell tumor and one region resembling granulosa-cell tumor, with extensive microfollicular pattern and many Call-Exner bodies.
  • Histologic examination of the abdominal tumor showed multifocal formation of Call-Exner bodies in an otherwise highly dedifferentiated population.
  • Positive immunolabeling for alpha inhibin confirmed the sex cord-stromal origin of the abdominal and paravertebral tumor masses.
  • This case has similarities to malignant testicular granulosa-cell tumor of humans.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Reprod Domest Anim. 2004 Oct;39(5):376-9 [15367273.001]
  • [Cites] Acta Cytol. 2004 May-Jun;48(3):315-20 [15192945.001]
  • [Cites] Vet Pathol. 1981 Mar;18(2):201-7 [7467079.001]
  • [Cites] Vet Pathol. 1988 Mar;25(2):163-6 [2834860.001]
  • [Cites] Vet Pathol. 1987 Nov;24(6):575-7 [2842920.001]
  • [Cites] J Med Primatol. 1992 Jan;21(1):39-41 [1602459.001]
  • [Cites] Vet Pathol. 1993 May;30(3):287-95 [8392765.001]
  • [Cites] Hum Pathol. 1993 Oct;24(10):1120-5 [8406422.001]
  • [Cites] Vet Pathol. 1995 Jan;32(1):91-2 [7725608.001]
  • [Cites] Gastroenterology. 1996 Jan;110(1):102-15 [8536845.001]
  • [Cites] Hum Pathol. 1997 Oct;28(10):1206-10 [9343329.001]
  • [Cites] Am J Surg Pathol. 1998 Jun;22(6):709-21 [9630178.001]
  • [Cites] Arch Pathol Lab Med. 1998 Oct;122(10):907-11 [9786352.001]
  • [Cites] Diagn Cytopathol. 1998 Nov;19(5):375-7 [9812234.001]
  • [Cites] Cell Tissue Res. 1999 May;296(2):385-94 [10382280.001]
  • [Cites] J Small Anim Pract. 2004 Nov;45(11):539-45 [15553191.001]
  • [Cites] Mod Pathol. 2005 Feb;18 Suppl 2:S81-98 [15502809.001]
  • [Cites] Urol Int. 2005;75(1):91-3 [16037716.001]
  • [Cites] Clinics (Sao Paulo). 2006 Feb;61(1):77-8 [16532229.001]
  • [Cites] Tumori. 2007 Mar-Apr;93(2):223-4 [17557577.001]
  • [Cites] Urol Oncol. 2007 Jul-Aug;25(4):322-5 [17628299.001]
  • [Cites] Int J Surg Pathol. 2007 Jul;15(3):321-5 [17652550.001]
  • [Cites] Acta Cytol. 2007 Jul-Aug;51(4):634-6 [17718142.001]
  • [Cites] Vet Pathol. 2007 Nov;44(6):936-43 [18039910.001]
  • [Cites] Diagn Cytopathol. 1992;8(3):253-7 [1606882.001]
  • [Cites] Mol Cell Endocrinol. 2000 May 25;163(1-2):73-9 [10963877.001]
  • [Cites] Arch Pathol Lab Med. 2000 Oct;124(10):1525-8 [11035589.001]
  • [Cites] Adv Anat Pathol. 2003 Jan;10(1):27-38 [12502966.001]
  • [Cites] J Vet Med A Physiol Pathol Clin Med. 2002 Dec;49(10):535-7 [12549834.001]
  • [Cites] Mod Pathol. 2003 Jun;16(6):584-90 [12808064.001]
  • [Cites] J Comp Pathol. 2004 Feb-Apr;130(2-3):229-33 [15003485.001]
  • [Cites] J Med Primatol. 1980;9(5):319-22 [7441719.001]
  • (PMID = 18984797.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / K01RR24120; United States / NCRR NIH HHS / RR / T32 RR007000; United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / T32 RR007000-32; United States / NCRR NIH HHS / RR / RR007000-32; United States / NCRR NIH HHS / RR / K01 RR024120
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 37
  • [Other-IDs] NLM/ NIHMS93232; NLM/ PMC2660595
  •  go-up   go-down


53. Cao Avellaneda E, Alarcón Martínez H, Fuster Soler JL, López Cubillana P, Llinares Riestra E, Pérez Albacete M: [Testicular and paratesticular prepuberal tumors: our experience and update on the topic]. Actas Urol Esp; 2005 Apr;29(4):355-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Testicular and paratesticular prepuberal tumors: our experience and update on the topic].
  • [Transliterated title] Tumores testiculares y paratesticulares prepuberales. Experiencia en nuestro centro y revisión de la literatura.
  • OBJECTIVES: To evaluate the importance of testicular and paratesticular prepubertal tumors in our center and to make an update on the topic.
  • METHODS AND PATIENTS: Data from all patients diagnosed of testicular and paratesticular prepubertal tumors and treated in our pediatric oncology unit from January 1st 1998 to December 31st 2003 have been revised.
  • RESULTS: Seven cases are reported among one hundred and ninety patients (represents 3,68 percent of all treated tumors): five tumors affecting the testis and two cases of paratesticular tumors.
  • Pathology classification was as follows: one yolk sack tumor, one mature teratoma, two nongerminomatous testicular tumors (one Sertoli cell tumor and one unclassifiable), one Burkitt's lymphoma and two paratesticular rhabdomyosarcomas.
  • CONCLUSIONS: Testicular and paratesticular prepubertal tumors are rare.
  • [MeSH-major] Testicular Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15981422.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


54. Brehm R, Rey R, Kliesch S, Steger K, Marks A, Bergmann M: Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome. Anat Embryol (Berl); 2006 Jun;211(3):223-36
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome.
  • During puberty, normal somatic Sertoli cells undergo dramatic morphological changes due to the differentiation of immature pre-Sertoli cells in functionally active adult Sertoli cells.
  • Sertoli cell maturation is accompanied with loss of their mitotic activity before onset of spermatogenesis and loss of pre-pubertal and occurrence of adult immunohistochemical Sertoli cell differentiation markers.
  • Testes of infertile adult patients often exhibit numerous histological signs of testicular dysgenesis syndrome (TDS) such as microliths, Sertoli cell only (SCO) tubules, tubules containing carcinoma in situ and immature seminiferous tubules (Sertoli cell nodules).
  • Sertoli cell tumours, however, are very rare neoplasms possibly due to the fact that the mechanism and temporal origin of neoplastic Sertoli cells underlying Sertoli cell tumourigenesis still remain unknown.
  • To clarify the state of Sertoli cell differentiation in both immature seminiferous tubules of adult patients with TDS and Sertoli cell tumour, we compared the expression of the Sertoli cell differentiation markers vimentin, inhibin-alpha, anti-Muellerian-hormone, cytokeratin 18, M2A-antigen, androgen receptor and connexin43 with that of SCO tubules with hyperplasia.
  • In addition, we demonstrated for the first time the existence of proliferating Sertoli cells by Ki67- and PCNA-immunostaining in Sertoli cell nodules of the adult human testis.
  • Our data indicate that mitotically active Sertoli cells in Sertoli cell nodules will be arrested prior to puberty and, contrary to dogma, do not represent foetal or neonatal cells.
  • Since all markers in Sertoli cell nodules revealed a staining pattern identical to that in neoplastic Sertoli cells, but different to that in Sertoli cells of SCO tubules with hyperplasia, it may be speculated that Sertoli cell tumours in adult men may originate from Sertoli cell nodules.
  • [MeSH-major] Gonadal Dysgenesis / pathology. Mitosis / physiology. Sertoli Cells / cytology. Spermatic Cord / cytology. Testis / cytology
  • [MeSH-minor] Adult. Child. Humans. Immunohistochemistry. Male. Sertoli Cell Tumor / pathology. Syndrome

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16429274.001).
  • [ISSN] 0340-2061
  • [Journal-full-title] Anatomy and embryology
  • [ISO-abbreviation] Anat. Embryol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


55. Zhao C, Vinh TN, McManus K, Dabbs D, Barner R, Vang R: Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. Am J Surg Pathol; 2009 Mar;33(3):354-66
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors.
  • Different immunohistochemical sex cord-stromal markers have been previously studied in various types of ovarian sex cord-stromal tumors; however, the sensitivity for sex cord-stromal lineage may vary between markers, and some markers may not be as sensitive in some types of sex cord-stromal tumors compared with other tumors in this spectrum of neoplasms.
  • The goals of this study were to determine which immunohistochemical markers are the most sensitive and immunohistochemically robust for sex cord-stromal lineage within a given type of ovarian sex cord-stromal tumor, and to establish whether there are substantial differences of expression of these markers between different types of sex cord-stromal tumors.
  • Immunohistochemical stains for markers which have known variable specificity for sex cord-stromal lineage [inhibin, calretinin, MART-1/melan-A, CD99, steroidogenic factor 1 (SF-1, adrenal 4-binding protein), and WT1], were performed in 127 cases of 5 different types of ovarian sex cord-stromal tumors: adult granulosa cell tumor (n=32), Sertoli cell tumor (n=27), Sertoli-Leydig cell tumor (n=18), steroid cell tumor (n=25), and fibroma/fibrothecoma (n=25).
  • All cases in each type of sex cord-stromal tumor expressed SF-1.
  • Inhibin and calretinin were expressed in all groups of tumors but with a lesser frequency (56% to 100% and 36% to 100% of cases, respectively).
  • All types of tumors except steroid cell tumor expressed WT1.
  • Fibroma/fibrothecoma was the only type of tumor that did not express CD99.
  • The only tumor groups that showed expression of MART-1 were Sertoli-Leydig cell tumor (restricted to the Leydig cell component) and steroid cell tumor (94% and 96% of cases, respectively).
  • The type of sex cord-stromal tumor that was least frequently positive for several of the different markers studied was fibroma/fibrothecoma.
  • Among all tumor groups combined, inhibin and WT1 were the 2 markers showing the most diffuse expression.
  • Likewise, the single marker showing the most optimal combination of diffuse and strong staining (immunohistochemical composite score: possible range, 1 to 12) varied between tumors: adult granulosa cell tumor-inhibin (score 10.0); Sertoli cell tumor-WT1 (score 10.8); Sertoli-Leydig cell tumor (Sertoli cell component)-WT1 (score 10.4); steroid cell tumor-inhibin (score 11.2); and fibroma/fibrothecoma-WT1 (score 8.9).
  • Although each of the different types of sex cord-stromal tumors has a slightly unique immunoprofile in terms of frequency and extent of expression, these differences are relatively minor for most types of tumors with certain exceptions (eg, WT1 is not diagnostically useful in steroid cell tumor; CD99 is not diagnostically useful in fibroma/fibrothecoma; the only sex cord-stromal tumor for which MART-1 is diagnostically useful is steroid cell tumor; inhibin and calretinin are less diagnostically useful in fibroma/fibrothecoma than in the other types of tumors, but expression in fibrothecoma was higher than in fibroma).
  • SF-1 is the most sensitive sex cord-stromal marker among the most common types of sex cord-stromal tumors.
  • Given the findings relating to sensitivity and extent of expression in this study, and known specificity in the literature, the most informative sex cord-stromal markers to be used for the distinction from nonsex cord-stromal tumors are inhibin, calretinin, SF-1, and WT1 (the exact number of markers to be used should be based on the degree of difficulty of the case and level of experience of the pathologist); however, the utility of immunohistochemistry for the diagnosis of fibroma/fibrothecoma is somewhat limited.
  • [MeSH-major] Biomarkers, Tumor / analysis. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19033865.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


56. Brown B, Ram A, Clayton P, Humphrey G: Conservative management of bilateral Sertoli cell tumors of the testicle in association with the Carney complex: a case report. J Pediatr Surg; 2007 Sep;42(9):E13-5
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of bilateral Sertoli cell tumors of the testicle in association with the Carney complex: a case report.
  • Large cell calcifying Sertoli cell tumor of the testicle is a rare, hormonally active sex cord-stromal tumor seen in patients with Carney complex.
  • When such tumors occur bilaterally, treatment options for preserving fertility and addressing the secondary effects of excess hormone production must be considered.
  • The availability of specific antiestrogen drugs means that bilateral orchiectomy for this benign tumor may no longer be warranted.
  • Testicular-sparing surgery and advances in reproductive technology may also improve the overall prognosis for fertility.
  • In all cases, a thorough history and physical examination are required to exclude nonphysiologic causes such as drugs, pulmonary disease, chronic liver disease, exogenous estrogens, and estrogen-producing tumors (Seashore J.
  • We report on a child who presented with a 2-year history of gynecomastia with associated bilateral testicular swellings and discuss a novel treatment strategy for managing bilateral testicular tumors in the context of the Carney complex.
  • [MeSH-major] Multiple Endocrine Neoplasia / diagnosis. Sertoli Cell Tumor / therapy. Testicular Neoplasms / therapy

  • Genetic Alliance. consumer health - Carney Complex.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17848226.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


57. Brazzell JL, Weiss DJ: A retrospective study of aplastic pancytopenia in the dog: 9 cases (1996-2003). Vet Clin Pathol; 2006 Dec;35(4):413-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Signalment, treatment given, previous and current disease conditions, clinical signs of disease, clinical laboratory data, therapy, response to therapy, and survival time were recorded.
  • Two dogs (22%) had associated diseases that included monocytic ehrlichiosis and Sertoli cell tumor.
  • One dog was living 3 years after diagnosis, but hematologic recovery was never documented.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17123247.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


58. Oliva E, Alvarez T, Young RH: Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol; 2005 Feb;29(2):143-56
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases.
  • Ovarian Sertoli cell tumors are rare, and their morphologic spectrum, behavior, and factors influencing the latter are not clearly established.
  • They may be mimicked by many different tumors, some of them more frequent than Sertoli cell tumors; immunohistochemistry may aid in this differential, but its role has not been analyzed in a large series.
  • We studied the clinicopathologic features of 54 Sertoli cell tumors, including the immunohistochemical profile of 23 of them.
  • The tumors ranged from 0.8 to 30 cm, with the majority being in the range of 4 to 12 cm.
  • The predominant microscopic pattern was tubular, seen, albeit often only focally, in all tumors; other patterns were cords or trabeculae (28), diffuse (21), pseudopapillary (4), retiform (3), islands or alveolar arrangements (3), and spindled (3).
  • Delicate septa were occasionally seen and were conspicuous in areas of one tumor.
  • The stroma was abundant in 15 tumors with marked sclerosis in 4.
  • The cells usually had pale to occasionally densely eosinophilic cytoplasm, but 6 tumors were composed of cells with prominent foamy cytoplasm, falling in the category of "lipid-rich" Sertoli cell tumor, and one had cells with clear non-foamy cytoplasm.
  • Forty-four tumors were stage I (42 of them were stage Ia and 2 were stage Ic), 1 was stage II, 3 were stage III, and 6 were not adequately staged.
  • Follow-up was available for 27 patients with stage I tumors, and all were alive and well at last follow-up except for 2 patients with stage Ia and 1 with stage Ic disease.
  • Those 3 patients had pelvic-abdominal recurrences 18, 36, and 9 months, respectively, after the initial diagnosis.
  • Two of the three clinically malignant stage I tumors had moderate to severe cytologic atypia and brisk mitotic activity (>5 or more mitoses/10 high power fields [HPFs]), and one of these had tumor cell necrosis.
  • Among the 10 clinically benign stage I tumors with more than 5 years of follow-up, only 3 had >5 mitoses/10 HPFs, but none had more than mild cytologic atypia and none had tumor cell necrosis.
  • Two of the three patients with stage III disease had follow-up information and one was alive at 16 months and the second developed splenic metastases 2 years after the initial diagnosis.
  • Two of the three stage III tumors had at least moderate cytologic atypia and brisk mitotic activity.
  • Immunohistochemical stains showed positivity for AE1/3-Cam5.2 in 15 of 23 tumors; Epithelial membrane antigen (EMA) was negative in all the tumors.
  • Inhibin was positive in 18 of 22 tumors, calretinin in 10 of 20, CD99 in 19 of 22, vimentin in 17 of 18, smooth muscle actin in 4 of 18, neuron specific enolase in 8 of 16, S-100 in 2 of 20, and chromogranin was negative in all 21 cases studied.
  • Although Sertoli cell tumors usually have a distinctive tubular pattern that facilitates the diagnosis, other patterns may occasionally predominate, causing confusion with various other primary and metastatic ovarian tumors.
  • EMA, inhibin, and chromogranin represent the most helpful triad of immunomarkers serving to exclude two common mimics of Sertoli cell tumors (endometrioid carcinoma [inhibin-; EMA+; chromogranin-] and carcinoid tumor [inhibin-; EMA+; chromogranin+]).
  • Although CD99 and calretinin are often expressed in these tumors, they are much less specific and not as helpful in the differential diagnosis.
  • Most Sertoli cell tumors are stage I, unilateral, cytologically bland, and clinically benign, but occasional examples are high stage, and about 11% of stage I tumors have worrisome histologic features that may portend an adverse outcome.
  • The tumors typically occur in young females, sometimes children who typically present with sexual precocity, and occasional patients have Peutz-Jeghers syndrome.
  • [MeSH-major] Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sertoli Cell Tumor / metabolism. Sertoli Cell Tumor / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / analysis. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Prognosis

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15644771.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


59. Ulbright TM, Young RH: Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features. Am J Surg Pathol; 2008 Nov;32(11):1683-93
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features.
  • Metastatic carcinomas to the testis may simulate primary testicular neoplasms, even in patients with known extratesticular primaries, but information on this topic is limited.
  • The tumors occurred in men 29 to 90 years old, with the prostate the most common primary site (N=11), followed by the renal parenchyma (N=4), colon (N=4), urinary tract (N=3), lung (N=2), esophagus (N=1), and, most probably, small intestine (carcinoid, N=1).
  • Noteworthy findings included: the frequent absence of a known primary tumor (62%), the rarity of bilateral involvement (8%), the occasional lack of a distinct mass on gross examination (15%), the infrequency of multinodularity either grossly (8%) or microscopically (35%), the prominence of intertubular growth (42%), conspicuous intrarete or intratubular growth in some cases (especially prostate carcinoma) (19%), prominent cytoplasmic vacuoles in occasional cases (15%), and the frequent presence of lymphatic involvement (69%).
  • Four tumors (3 prostate, 1 renal) with prominent intrarete and/or intratubular growth had submitting diagnoses of either a primary rete neoplasm or seminoma.
  • Four tumors (2 prostate, 1 renal, and 1 bladder) with prominently vacuolated pale cells simulated Sertoli cell tumor.
  • We conclude that, if autopsy cases and incidental tumors in therapeutic orchiectomy specimens are excluded, metastatic carcinomas to the testis are usually solitary, unilateral tumors that may simulate primary neoplasms, including rete adenocarcinoma and Sertoli cell tumor.
  • Despite the rarity of documented cases in the literature, the bladder and renal pelvis should not be overlooked as possible sources for testicular metastasis.
  • The pathologist must have a high index of suspicion for the possibility of a metastatic carcinoma to the testis for any testicular tumor where the routine light microscopic or immunohistochemical findings are unusual for a primary neoplasm.
  • [MeSH-major] Carcinoma / secondary. Testicular Neoplasms / secondary

  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18769334.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


60. Vakiani E, Young RH, Carcangiu ML, Klimstra DS: Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. Am J Surg Pathol; 2008 Oct;32(10):1540-5
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases.
  • We report 4 cases of acinar cell carcinoma of the pancreas, 3 presenting as metastases in the ovary, the first report of this circumstance, which may pose a broad differential diagnosis and caused significant diagnostic difficulty in all the cases.
  • In 3 cases, the ovarian tumors were detected before the pancreatic tumor; in 1 case, a large abdominal mass and ovarian tumors were discovered synchronously.
  • The ovarian tumors were large, solid, white-tan on gross examination, and bilateral in 3 cases; the single case involving only 1 ovary had 2 discrete masses of tumor.
  • The main differential diagnostic consideration was well-differentiated neuroendocrine neoplasm (carcinoid tumor); positive immunostaining with antibodies against chymotrypsin and trypsin and negative immunostaining with antibodies against synaptophysin and chromogranin helped exclude this diagnosis.
  • We observed focal alpha-inhibin immunostaining in 2 cases, which may represent a potential diagnostic pitfall, as a Sertoli cell tumor or unusual granulosa cell tumor may also enter the differential diagnosis.
  • Inclusion of antibodies against the pancreatic enzymes chymotrypsin and trypsin in the immunohistochemical panel is critical in establishing the correct diagnosis and should be considered when evaluating ovarian tumors with architectural (mainly acinar) and cytologic (granular eosinophilic cytoplasm) characteristics that should bring a metastatic acinar cell carcinoma into consideration.
  • [MeSH-major] Carcinoma, Acinar Cell / secondary. Ovarian Neoplasms / secondary. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Middle Aged

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18724247.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


61. Young RH: Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol; 2005 Feb;18 Suppl 2:S81-98
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
  • Gonadal sex cord-stromal tumors contain some of the most morphologically interesting neoplasms of the gonads and these lead to many important issues in differential diagnosis.
  • The pathology of these tumors is reviewed with emphasis on new information, similarities and differences in the two gonads, and diagnostic problems.
  • Sertoli cell tumors occur in both gonads being more common in the testis where they usually exhibit a lobular pattern of hollow or solid tubules.
  • In the ovary, tubular differentiation is usually the predominant feature but the lobulation typically seen in the testis is generally not as striking.
  • One variant of Sertoli cell tumor, the large cell calcifying form, appears to be restricted to the male gonad and in contrast to other sex cord tumors is much more frequently bilateral and is associated in many cases with unusual clinical manifestations.
  • In females, it is in the form of the sex cord with annular tubules whereas in males, the lesion has features that are often intermediate between those of a sex cord tumor with annular tubules and a large cell calcifying Sertoli cell tumor.
  • Sertoli-Leydig cell tumors are more morphologically diverse than pure Sertoli cell tumors and for practical purposes are an issue only in ovarian pathology being exceptionally rare in the testis.
  • The classification proposed by Meyer into well, intermediate, and poor differentiation, remains important prognostically.
  • Heterologous tumors most often contain mucinous epithelium, sometimes with small foci of carcinoid or less commonly, and generally in poorly differentiated neoplasms, rhabdomyosarcoma or fetal-type cartilage.
  • Such tumors should be distinguished from pure sarcomas and teratomas.
  • The retiform neoplasms, which tend to occur in young females, may mimic serous borderline tumors or even serous carcinomas.
  • Granulosa cell tumors are much more common in females and in both gonads are divided into adult and juvenile forms.
  • In females, granulosa cell tumors and other sex cord tumors may have markedly bizarre nuclei potentially leading to overdiagnosis as more malignant neoplasms.
  • The juvenile granulosa cell tumor of the testis tends to occur in the first 6 months of life and should be carefully distinguished from the yolk sac tumor of the testis, which usually occurs in a slightly older age group.
  • Occasional sex cord-stromal tumors cannot be readily categorized into the Sertoli or granulosa families and are diagnosed as sex cord-stromal tumors unclassified.
  • In females, this is a relatively common placement for a neoplasm in a pregnant patient.
  • Unclassified tumors are overall more common in males and may entrap residual normal germ cells potentially leading to the erroneous placement of the tumor in the category of a mixed germ cell sex cord-stromal tumor.
  • From the practical viewpoint, the most helpful immunohistochemical findings are the negative staining of sex cord tumors for epithelial membrane antigen, and positive staining for inhibin and calretinin, findings that are converse to those seen in endometrioid carcinomas of the ovary, which commonly have formations that simulate sex cord tumors.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Granulosa Cell Tumor / pathology. Humans. Male. Sertoli Cell Tumor / pathology

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15502809.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
  •  go-up   go-down


62. McCluggage WG, McKenna M, McBride HA: CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. Int J Gynecol Pathol; 2007 Jul;26(3):322-7
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors.
  • Ovarian sex cord-stromal tumors comprise a heterogeneous group of neoplasms with wide morphological diversity, and they can be mistaken for a variety of other tumors.
  • Some types, including granulosa and Sertoli cell tumor, may be confused with a neuroendocrine neoplasm.
  • CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and is commonly used as part of a panel to distinguish between a neuroendocrine neoplasm and other tumors in the differential diagnosis.
  • In this study, we investigate CD56 staining in ovarian sex cord-stromal tumors.
  • Neoplasms studied were adult granulosa cell tumor (n = 40), juvenile granulosa cell tumor (n = 8), Sertoli cell tumor (n = 1), Sertoli-Leydig cell tumor (n = 14), Leydig cell tumor (n = 2), steroid cell tumor, not otherwise specified (n = 2), sclerosing stromal tumor (n = 1), sex cord tumor with annular tubules (n = 2), and fibroma (n = 15).
  • Three uterine tumors resembling ovarian sex cord tumor were also studied.
  • Nonneoplastic ovaries, including 3 cases of pregnancy-related granulosa or Sertoli cell proliferation, were also included.
  • All sex cord-stromal tumors except one were positive with CD56; staining ranged from focal to diffuse but was usually diffuse involving more than 50% of tumor cells.
  • CD56 immunoreactivity is almost universal in ovarian sex cord-stromal tumors of all the major morphological types and is of no value in distinguishing a sex cord-stromal and a neuroendocrine neoplasm.
  • Since CD56 is an extremely sensitive marker of ovarian sex cord-stromal tumors, it may be useful in the diagnosis of this group of neoplasms, especially in cases which are alpha inhibin or calretinin negative, and in distinguishing these from mimics which are CD56 negative.
  • [MeSH-major] Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Ovarian Neoplasms / metabolism. Sex Cord-Gonadal Stromal Tumors / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17581419.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor
  •  go-up   go-down


63. Chivukula M, Hunt J, Carter G, Kelley J, Patel M, Kanbour-Shakir A: Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis. Int J Gynecol Pathol; 2007 Jan;26(1):30-3
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gynandroblastoma is a rare ovarian tumor that is composed of both Sertoli cells and granulosa cells.
  • A 49-year-old Gravida 0 woman with a 10-year prior diagnosis of ovarian-mixed stromal tissue tumor (well-differentiated Sertoli cell and granulosa cell tumor) and staging laparotomy, presented now with a retroperitoneal mass and an elevated inhibin level.
  • The histomorphological features of the recurrent tumor had both Sertoli cell and granulosa cell tumor.
  • The molecular analysis of both primary and recurrent tumor showed minor genetic instability in the 17q12.2 gene locus with no dedifferentiation or progression, which is consistent with a low-grade tumor.
  • All the previously mentioned immunostainings support the diagnosis.
  • [MeSH-major] Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology

  • Genetic Alliance. consumer health - Gynandroblastoma.
  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17197894.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


64. Ye L, Wu XL, Xu L, Huang Q, Sun L, He Y, Yang KX: [Ovarian steroid cell tumor, not otherwise specified: a clinicopathologic study]. Zhonghua Bing Li Xue Za Zhi; 2007 Aug;36(8):516-20
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ovarian steroid cell tumor, not otherwise specified: a clinicopathologic study].
  • OBJECTIVE: To study the clinicopathologic features, diagnostic criteria, differential diagnosis and treatment options of ovarian steroid cell tumor, not otherwise specified (NOS).
  • METHODS: Light microscopy and immunohistochemical study was carried out in 8 cases of ovarian steroid cell tumor, NOS.
  • RESULTS: The 7 cases of benign ovarian steroid cell tumor, NOS were composed mainly of polygonal cells with granular eosinophilic cytoplasm and larger cells with vacuolated cytoplasm.
  • They resembled the architecture of normal adrenal gland, with formation of cell nests and trabeculae.
  • The single case of malignant ovarian steroid cell tumor had evidence of significant cellular pleomorphism, haemorrhage and coagulative tumor necrosis.
  • Immunohistochemical study showed that the tumor cells expressed calretinin and alpha-inhibin.
  • Differential diagnosis included oxyphilic granulosa cell tumor, thecoma, Sertoli cell tumor and clear cell carcinoma.
  • The treatment options of benign ovarian steroid cell tumor, NOS was local excision or ipsilateral salpingo-oophorectomy, while the malignant counterpart should be treated with a combination of surgery and chemotherapy, including administration of GnRH agonist.
  • CONCLUSIONS: Ovarian steroid cell tumor, NOS, is the most common type of ovarian steroid cell tumors.
  • Immunohistochemistry is an important adjunct for diagnosis.
  • The treatment options of ovarian steroid cell tumor, NOS depend on its malignant potential.
  • [MeSH-major] Inhibins / metabolism. Ovarian Neoplasms / pathology. Ovary / pathology. S100 Calcium Binding Protein G / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology
  • [MeSH-minor] Adolescent. Adult. Calbindin 2. Diagnosis, Differential. Female. Granulosa Cell Tumor / pathology. Humans. Ovariectomy / methods. Sertoli Cell Tumor / pathology. Thecoma / pathology. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17980097.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
  • [Number-of-references] 27
  •  go-up   go-down


65. Mobasheri MB, Jahanzad I, Mohagheghi MA, Aarabi M, Farzan S, Modarressi MH: Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features. Cancer Detect Prev; 2007;31(4):296-302

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features.
  • BACKGROUND: Cancer-testis genes are a group of genes expressed in testicular germinal cells and a range of human cancers.
  • Testis-specific gene A10 (TSGA10) is expressed in testis and actively dividing and fetal differentiating tissues.
  • SYCP3 gene is supposed to be a testis-specific gene and constitutes the core of the lateral elements of synaptonemal complex.
  • METHODS: In this study expression of TSGA10 and SYCP3 were investigated in different cancers (156 tumor samples) using RT-PCR.
  • Diagnosis of cancer was based on histopathological reports.
  • The association with histopathological characteristics of tumors was analyzed using statistical programs.
  • RESULTS: TSGA10 expression was observed in 83% of brain tumors, 66% of breast cancers, 58% of gastrointestinal tumors, 66% of skin tumors and 53% of soft tissue tumors.
  • But, SYCP3 transcripts were found in four tumor samples (moderately differentiated gemistocytic astrocytoma, pituitary adenoma, glioma and an ovarian tumor).
  • CONCLUSION: These results may get further insight into TSGA10, but not SYCP3, potential role as a cancer marker and a cancer testis gene implicated in tumorogenesis of cancers.
  • [MeSH-major] Biomarkers, Tumor / genetics. Gene Expression. Neoplasms / genetics. Neoplasms / pathology. Nuclear Proteins / genetics. Proteins / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17920210.001).
  • [ISSN] 0361-090X
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Proteins; 0 / SYCP3 protein, human; 0 / TSGA10 protein, human
  •  go-up   go-down


66. Treiyer A, Blanc G, Stark E, Haben B, Treiyer E, Steffens J: Prepubertal testicular tumors: frequently overlooked. J Pediatr Urol; 2007 Dec;3(6):480-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prepubertal testicular tumors: frequently overlooked.
  • OBJECTIVE: Prepubertal testicular tumors are fundamentally distinct from their adult counterparts.
  • We reviewed our 10-year, two-institution experience with respect to diagnosis and treatment.
  • MATERIAL AND METHODS: A retrospective review was performed of all testicular tumors diagnosed between 1996 and 2006 in males younger than 14 years.
  • RESULTS: Of 15 primary testicular tumors, eight (53%) were germ-cell tumors (three teratomas, two yolk sac tumors, one seminoma, one embryonic carcinoma and one choriocarcinoma), four (27%) tumor-like lesions (epidermoid cysts), two (13%) gonadal stromal tumors (a Leydig and a Sertoli cell tumor), and one (7%) gonadoblastoma with gonadal dysgenesis.
  • All boys were presented with a painless scrotal mass and four (27%) of them with elevated tumor markers.
  • Twelve children (80%) were treated with radical orchiectomy and three (20%) with a testis-sparing procedure.
  • At a mean 4-year follow-up no patient has presented with recurrent tumor in the residual or contralateral testicle.
  • Postoperative physical examination and scrotal ultrasound were obtained in 14 patients at a median follow-up of 48.2 months, and there was no evidence of tumor progression.
  • CONCLUSIONS: Benign teratoma and epidermoid cysts were the most common prepubertal testicular tumors.
  • Any suspicion of a testicular tumor warrants an inguinal approach to prevent scrotal violation of the tumor.
  • Our limited experience with testis-sparing procedures supports the current trends that organ-confined surgery should be performed for benign lesions such as teratoma, Leydig cell tumor and epidermoid cysts based on frozen biopsy findings.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18947799.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


67. Dahlqvist P, Koskinen LO, Brännström T, Hägg E: Testicular enlargement in a patient with a FSH-secreting pituitary adenoma. Endocrine; 2010 Apr;37(2):289-93
Hazardous Substances Data Bank. MENOTROPINS .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular enlargement in a patient with a FSH-secreting pituitary adenoma.
  • Clinically non-functional pituitary adenomas are often derived from gonadotropin producing cells.
  • Magnetic resonance imaging (MRI) and biochemical examinations showed a large pituitary adenoma and excessive levels of serum FSH.
  • After pituitary surgery, serum FSH levels normalized and there was a decrease in testicular volume.
  • This case suggests that supraphysiological levels of FSH from a gonadotropinoma can cause a clinically observable effect, i.e. testicular enlargement.
  • This is in line with experimental studies showing biological effect of FSH from pituitary adenomas and previous occasional reports of ovarian hyperstimulation and testicular enlargement in patients with FSH-secreting gonadotropinomas.
  • [MeSH-major] Adenoma / pathology. Adenoma / secretion. Follicle Stimulating Hormone / secretion. Pituitary Neoplasms / pathology. Pituitary Neoplasms / secretion. Testis / pathology

  • MedlinePlus Health Information. consumer health - Pituitary Tumors.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20960265.001).
  • [ISSN] 1559-0100
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-68-0 / Follicle Stimulating Hormone
  •  go-up   go-down


68. Yu CH, Hwang DN, Yhee JY, Kim JH, Im KS, Nho WG, Lyoo YS, Sur JH: Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. J Vet Sci; 2009 Mar;10(1):1-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors.
  • Primary testicular tumors are the most common causes of cancer in male dogs.
  • Overall, the majority of canine patients should be cured by testicular surgery.
  • However, tumor markers are not well-known in veterinary medicine.
  • We sought to determine using immunohistochemistry whether the combined human testicular tumor markers (placental alkaline phosphatase, OCT3/4, CD30, alpha-fetoprotein, inhibin-alpha, vimentin, c-KIT, and desmin) are expressed in canine seminomas and Sertoli cell tumors (SCTs).
  • We examined 35 canine testicular tumors, 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas.
  • The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans.
  • All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression.
  • [MeSH-major] Dog Diseases / pathology. Immunohistochemistry / veterinary. Seminoma / veterinary. Sertoli Cell Tumor / veterinary
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Dogs. Male

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Reprod Fertil Dev. 1998;10(7-8):551-5 [10612460.001]
  • [Cites] J Vet Med Sci. 2007 Dec;69(12):1259-62 [18176022.001]
  • [Cites] Mol Hum Reprod. 2000 Nov;6(11):999-1004 [11044462.001]
  • [Cites] Reproduction. 2001 Feb;121(2):287-96 [11226053.001]
  • [Cites] Vet Pathol. 2001 Nov;38(6):661-6 [11732800.001]
  • [Cites] J Histochem Cytochem. 2002 Feb;50(2):283-5 [11799147.001]
  • [Cites] Histopathology. 2002 Aug;41(2):110-7 [12147087.001]
  • [Cites] Am J Surg Pathol. 2004 Jul;28(7):935-40 [15223965.001]
  • [Cites] Am J Surg Pathol. 2004 Oct;28(10):1341-6 [15371950.001]
  • [Cites] Cancer. 2004 Nov 1;101(9):2006-10 [15386301.001]
  • [Cites] Acta Pathol Microbiol Immunol Scand A. 1983 May;91(3):165-76 [6190350.001]
  • [Cites] Prog Clin Biol Res. 1985;203:1-34 [3008176.001]
  • [Cites] J Endocrinol. 1990 Nov;127(2):235-42 [2123496.001]
  • [Cites] J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):863-6 [2285598.001]
  • [Cites] J Comp Pathol. 1994 Apr;110(3):267-73 [8040391.001]
  • [Cites] J Pathol. 1995 Nov;177(3):253-8 [8551387.001]
  • [Cites] Br J Urol. 1996 Jan;77(1):138-42 [8653285.001]
  • [Cites] Am J Surg Pathol. 1998 May;22(5):615-9 [9591732.001]
  • [Cites] Mol Hum Reprod. 1999 Sep;5(9):851-60 [10460224.001]
  • [Cites] Biochem Biophys Res Commun. 2005 Nov 11;337(1):289-96 [16188233.001]
  • [Cites] Zhonghua Bing Li Xue Za Zhi. 2005 Nov;34(11):711-5 [16536313.001]
  • [Cites] Hum Pathol. 2006 Jun;37(6):662-7 [16733205.001]
  • [Cites] Histopathology. 2006 Sep;49(3):290-7 [16918976.001]
  • [Cites] Anal Quant Cytol Histol. 2006 Aug;28(4):181-7 [16927637.001]
  • [Cites] Mod Pathol. 2007 Mar;20(3):320-5 [17277761.001]
  • [Cites] Vet Pathol. 2007 May;44(3):394-7 [17491086.001]
  • [Cites] Anticancer Res. 2007 May-Jun;27(3B):1685-8 [17595797.001]
  • [Cites] J Comp Pathol. 2007 Jul;137(1):41-6 [17629966.001]
  • [Cites] Int J Androl. 2007 Aug;30(4):192-7 [17705803.001]
  • [Cites] Vet Pathol. 2007 Nov;44(6):936-43 [18039910.001]
  • [Cites] Hum Pathol. 2000 Sep;31(9):1055-61 [11014571.001]
  • (PMID = 19255517.001).
  • [ISSN] 1229-845X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2801099
  •  go-up   go-down


69. Veeramachaneni DN, Amann RP, Jacobson JP: Testis and antler dysgenesis in sitka black-tailed deer on Kodiak Island, Alaska: Sequela of environmental endocrine disruption? Environ Health Perspect; 2006 Apr;114 Suppl 1:51-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testis and antler dysgenesis in sitka black-tailed deer on Kodiak Island, Alaska: Sequela of environmental endocrine disruption?
  • We sought to better understand the problem and investigated 171 male deer for phenotypic aberrations and 12 for detailed testicular histopathology.
  • All 11 abdominal testes examined had no spermatogenesis but contained abnormalities including carcinoma in situ-like cells, possible precursors of seminoma; Sertoli cell, Leydig cell, and stromal cell tumors; carcinoma and adenoma of rete testis; and microlithiasis or calcifications.
  • However, based on lesions observed, we hypothesize that it is more likely that this testis-antler dysgenesis resulted from continuing exposure of pregnant females to an estrogenic environmental agent(s), thereby transforming testicular cells, affecting development of primordial antler pedicles, and blocking transabdominal descent of fetal testes.
  • [MeSH-major] Antlers / abnormalities. Deer. Endocrine Disruptors / toxicity. Gonadal Dysgenesis / chemically induced. Testis / abnormalities
  • [MeSH-minor] Alaska. Animals. Cryptorchidism / chemically induced. Cryptorchidism / complications. Cryptorchidism / genetics. Environmental Exposure / adverse effects. Estrogens / toxicity. Hyperplasia / chemically induced. Leydig Cells / cytology. Leydig Cells / drug effects. Male. Testicular Neoplasms / chemically induced. Testicular Neoplasms / etiology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Reprod Fertil Dev. 2001;13(4):307-15 [11800169.001]
  • [Cites] Environ Health Perspect. 1996 Aug;104 Suppl 4:741-803 [8880001.001]
  • [Cites] J Environ Biol. 2002 Apr;23(2):189-97 [12602857.001]
  • [Cites] Toxicol Sci. 2003 Apr;72(2):301-13 [12655036.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Sep;88(9):4273-9 [12970298.001]
  • [Cites] Toxicol Lett. 2004 Feb 2;146(3):207-15 [14687758.001]
  • [Cites] Dev Biol. 2004 Jun 1;270(1):1-18 [15136137.001]
  • [Cites] J Mammal. 1967 Nov;48(4):674-6 [6070650.001]
  • [Cites] Lancet. 1972 Sep 9;2(7776):516-7 [4115573.001]
  • [Cites] J Wildl Dis. 1997 Jul;33(3):420-9 [9249686.001]
  • [Cites] J Wildl Dis. 1997 Jul;33(3):670-2 [9249723.001]
  • [Cites] Mol Endocrinol. 1999 May;13(5):681-91 [10319319.001]
  • [Cites] Nat Genet. 1999 Jul;22(3):295-9 [10391220.001]
  • [Cites] Am J Vet Res. 1964 Jan;25:179-85 [14103222.001]
  • [Cites] J Nutr. 2005 Feb;135(2):296-300 [15671230.001]
  • [Cites] Science. 2005 Jun 3;308(5727):1466-9 [15933200.001]
  • [Cites] Int J Androl. 2006 Feb;29(1):235-40 [16466544.001]
  • [Cites] J Embryol Exp Morphol. 1973 Apr;29(2):431-7 [4717976.001]
  • [Cites] Endocrinology. 1974 Apr;94(4):1034-40 [4818767.001]
  • [Cites] J Reprod Fertil. 1974 Jul;39(1):115-8 [4854121.001]
  • [Cites] J Wildl Dis. 1975 Jan;11(1):101-6 [163381.001]
  • [Cites] J Exp Zool. 1975 Nov;194(2):349-58 [1194873.001]
  • [Cites] Can J Zool. 1976 Oct;54(10):1617-36 [974930.001]
  • [Cites] J Reprod Fertil. 1979 Sep;57(1):127-30 [41942.001]
  • [Cites] J Reprod Fertil. 1984 May;71(1):7-15 [6374134.001]
  • [Cites] Cancer Res. 1985 Oct;45(10):5145-50 [4027990.001]
  • [Cites] Am J Vet Res. 1986 Sep;47(9):1988-99 [3094413.001]
  • [Cites] J Urol. 1987 Dec;138(6):1446-50 [3682076.001]
  • [Cites] Endocrinology. 2000 Feb;141(2):846-9 [10650968.001]
  • [Cites] Anim Reprod Sci. 2000 Jul 2;60-61:121-30 [10844189.001]
  • [Cites] Carcinogenesis. 2000 Jul;21(7):1355-63 [10874014.001]
  • [Cites] Dev Biol. 2000 Aug 15;224(2):354-61 [10926772.001]
  • [Cites] Hum Reprod. 2001 May;16(5):972-8 [11331648.001]
  • [Cites] Hum Reprod Update. 2001 May-Jun;7(3):248-64 [11392371.001]
  • [Cites] Am J Vet Res. 2001 Aug;62(8):1198-206 [11497438.001]
  • [Cites] Anat Embryol (Berl). 2001 Nov;204(5):375-88 [11789985.001]
  • [Cites] J Hered. 1988 Jul-Aug;79(4):313-4 [2901444.001]
  • [Cites] J Exp Zool. 1993 Nov 1;267(3):288-98 [8228867.001]
  • [Cites] J Androl. 1993 Nov-Dec;14(6):397-406 [8294222.001]
  • [Cites] Environ Health Perspect. 1993 Oct;101(5):378-84 [8080506.001]
  • [Cites] J Urol. 1995 Aug;154(2 Pt 1):553-7 [7609135.001]
  • [Cites] Hum Mol Genet. 2002 Sep 15;11(19):2309-18 [12217959.001]
  • (PMID = 16818246.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Endocrine Disruptors; 0 / Estrogens
  • [Other-IDs] NLM/ PMC1874179
  •  go-up   go-down


70. Ulbright TM, Amin MB, Young RH: Intratubular large cell hyalinizing sertoli cell neoplasia of the testis: a report of 8 cases of a distinctive lesion of the Peutz-Jeghers syndrome. Am J Surg Pathol; 2007 Jun;31(6):827-35
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intratubular large cell hyalinizing sertoli cell neoplasia of the testis: a report of 8 cases of a distinctive lesion of the Peutz-Jeghers syndrome.
  • We report the clinical and pathologic features of 8 boys with Peutz-Jeghers syndrome who had distinctive testicular lesions.
  • Physical examination demonstrated bilateral testicular enlargement in the absence of a discrete mass.
  • Testicular biopsy, performed in all cases, usually showed no gross abnormality, but on microscopic examination there were patchily distributed clusters of expanded seminiferous tubules that contained large Sertoli cells with vacuolated to eosinophilic cytoplasm admixed with globular deposits of basement membrane that extended from a thickened peritubular basement membrane.
  • Small, focal calcifications occurred in 3 cases; no invasive tumor was present in any of the cases.
  • Review of the previously reported cases of testicular lesions in Peutz-Jeghers patients verified a low frequency of invasive tumors (27%) and no known case with metastasis.
  • The testicular lesions seen in patients with Peutz-Jeghers syndrome mostly represent multifocal intratubular neoplasia of large Sertoli cells with unique morphology distinct from other lesions such as the large cell calcifying Sertoli cell tumor and sex cord tumor with annular tubules.
  • The process usually remains confined to the tubules for prolonged intervals (years), but it may occasionally progress to invasive large cell Sertoli cell tumors with or without associated calcification.
  • Orchiectomy is indicated when there is evidence of an invasive tumor and may be necessary to control hormonal manifestations.
  • [MeSH-major] Peutz-Jeghers Syndrome / complications. Sertoli Cell Tumor / complications. Sertoli Cell Tumor / pathology. Testicular Neoplasms / complications. Testicular Neoplasms / pathology

  • Genetic Alliance. consumer health - Peutz Jeghers syndrome.
  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17527069.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


71. Masserdotti C, De Lorenzi D, Gasparotto L: Cytologic detection of Call-Exner bodies in Sertoli cell tumors from 2 dogs. Vet Clin Pathol; 2008 Mar;37(1):112-4
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic detection of Call-Exner bodies in Sertoli cell tumors from 2 dogs.
  • A 14-year-old Italian Griffon and an 11-year-old mixed breed dog were presented to our clinic with monolateral testicular enlargement.
  • In both dogs, a firm, nodular, and nonpainful mass was palpated, and ultrasonographic examination of testicular parenchyma showed a large and irregular nodular area with hyperechogenic features.
  • Fine-needle aspirates of the masses were highly cellular and consisted of populations of large elongated vacuolated cells in sheets and palisades, with finely granular chromatin and prominent nucleoli, consistent with neoplastic Sertoli cells.
  • A variable number of structures also were observed that consisted of a central round area of amorphous, deeply eosinophilic, hyaline material surrounded by a peripheral, rosette-like arrangement of single or multiple rows of Sertoli cells.
  • Histologic sections of the tumors obtained following castration confirmed the diagnosis of Sertoli cell neoplasia and the presence of Call-Exner bodies.
  • Call-Exner bodies, thought to represent an attempt by neoplastic cells to form basement membrane, are seen most frequently in granulosa cell tumors, but are occasionally reported in testicular tumors that contain epithelial elements of sex-cord origin.
  • To our knowledge, this is the first description of Call-Exner bodies in cytologic specimens from dogs, and only the fifth report of their presence in canine testicular neoplasms.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18366553.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


72. Ge D, You Z: Expression of interleukin-17RC protein in normal human tissues. Int Arch Med; 2008;1(1):19
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Interleukin-17 (IL-17) cytokines and receptors play an important role in many autoimmune and inflammatory diseases.
  • RESULTS: IL-17RC expression in 51 normal human tissues and two benign tumors (i.e., lymphangioma and parathyroid adenoma) on the tissue microarrays was determined by immunohistochemical staining, using two polyclonal antibodies against IL-17RC.
  • IL-17RC protein was expressed in many cell types including the myocardial cells, vascular and lymphatic endothelial cells, glandular cells (of the adrenal, parathyroid, pituitary, thyroid, pancreas, parotid salivary, and subepidermal glands), epithelial cells (of the esophagus, stomach, intestine, anus, renal tubule, breast, cervix, Fallopian tube, epididymis, seminal vesicle, prostate, gallbladder, bronchus, lung, and skin), oocytes in the ovary, Sertoli cells in the testis, motor neurons in the spinal cord, autonomic ganglia and nerves in the intestine, skeletal muscle cells, adipocytes, articular chondrocytes, and synovial cells.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2078-87 [18310510.001]
  • [Cites] J Invest Dermatol. 2008 May;128(5):1207-11 [18200064.001]
  • [Cites] Cytokine. 2008 Feb;41(2):92-104 [18178098.001]
  • [Cites] Cytokine. 2008 Feb;41(2):105-13 [18061473.001]
  • [Cites] Cytokine. 2008 Feb;41(2):84-91 [18039580.001]
  • [Cites] J Clin Invest. 2008 Feb;118(2):597-607 [18202747.001]
  • [Cites] Nat Immunol. 2008 Feb;9(2):124-6 [18204425.001]
  • [Cites] J Immunol. 2008 Jan 1;180(1):655-63 [18097068.001]
  • [Cites] Cytokine. 2007 Oct;40(1):35-43 [17881243.001]
  • [Cites] J Immunol. 2007 Oct 15;179(8):5462-73 [17911633.001]
  • [Cites] Cytokine. 2007 Jun;38(3):157-64 [17644350.001]
  • [Cites] J Heart Lung Transplant. 2007 Jul;26(7):669-74 [17613395.001]
  • [Cites] Neoplasia. 2007 Jun;9(6):464-70 [17603628.001]
  • [Cites] Cell Res. 2007 May;17(5):435-40 [17452998.001]
  • [Cites] J Biol Chem. 2007 May 4;282(18):13447-55 [17355969.001]
  • [Cites] J Immunol. 2007 Apr 1;178(7):4466-72 [17372004.001]
  • [Cites] J Neuroimmunol. 2007 Feb;183(1-2):96-103 [17240458.001]
  • [Cites] J Immunol. 2007 Feb 1;178(3):1372-8 [17237384.001]
  • [Cites] J Immunol. 2006 Dec 15;177(12):8542-9 [17142752.001]
  • [Cites] J Immunol. 2006 Nov 15;177(10):6852-8 [17082599.001]
  • [Cites] Prostate. 2006 Sep 1;66(12):1268-74 [16688746.001]
  • [Cites] J Neurosci Res. 2006 Aug 1;84(2):379-88 [16676327.001]
  • [Cites] J Immunol. 2006 Jul 1;177(1):566-73 [16785554.001]
  • [Cites] J Immunol. 2006 Jul 1;177(1):36-9 [16785495.001]
  • [Cites] J Exp Med. 2006 Jul 10;203(7):1685-91 [16818675.001]
  • [Cites] Cell Signal. 2006 Aug;18(8):1287-98 [16310341.001]
  • [Cites] Cell Immunol. 2005 Oct;237(2):123-30 [16386239.001]
  • [Cites] Cancer Res. 2006 Jan 1;66(1):175-83 [16397230.001]
  • [Cites] J Immunol. 2006 Jan 15;176(2):711-5 [16393951.001]
  • [Cites] Nat Immunol. 2005 Nov;6(11):1123-32 [16200070.001]
  • [Cites] Nat Immunol. 2005 Nov;6(11):1133-41 [16200068.001]
  • [Cites] J Immunol. 2005 Nov 1;175(9):6177-89 [16237115.001]
  • [Cites] Am J Respir Cell Mol Biol. 2005 Sep;33(3):248-53 [15901616.001]
  • [Cites] J Immunol. 2005 Jul 1;175(1):404-12 [15972674.001]
  • [Cites] J Cell Physiol. 2005 Aug;204(2):560-6 [15799031.001]
  • [Cites] Immunity. 2005 Mar;22(3):285-94 [15780986.001]
  • [Cites] J Exp Med. 2005 Jan 17;201(2):233-40 [15657292.001]
  • [Cites] Biochem Biophys Res Commun. 2005 Jan 21;326(3):624-31 [15596145.001]
  • [Cites] Cancer Res. 2004 Nov 15;64(22):8276-84 [15548695.001]
  • [Cites] Cancer Res. 1999 Aug 1;59(15):3698-704 [10446984.001]
  • [Cites] J Immunol. 1999 Jan 1;162(1):577-84 [9886435.001]
  • [Cites] J Immunol. 1995 Dec 15;155(12):5483-6 [7499828.001]
  • [Cites] Immunity. 1995 Dec;3(6):811-21 [8777726.001]
  • [Cites] Immunity. 2004 Oct;21(4):467-76 [15485625.001]
  • [Cites] Joint Bone Spine. 2004 Mar;71(2):87-90 [15050191.001]
  • [Cites] Cell Mol Life Sci. 2004 Mar;61(5):567-79 [15004696.001]
  • [Cites] Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1229-34 [14742870.001]
  • [Cites] J Biol Chem. 2003 Dec 12;278(50):50273-82 [12958313.001]
  • [Cites] Br J Pharmacol. 2003 Oct;140(4):595-610 [14504135.001]
  • [Cites] J Biol Chem. 2003 Aug 29;278(35):33232-8 [12807873.001]
  • [Cites] Prostate. 2003 Aug 1;56(3):171-82 [12772186.001]
  • [Cites] Scand J Gastroenterol. 2003 Feb;38(2):180-5 [12678335.001]
  • [Cites] Cytokine Growth Factor Rev. 2003 Apr;14(2):155-74 [12651226.001]
  • [Cites] Gut. 2003 Jan;52(1):65-70 [12477762.001]
  • [Cites] Nat Med. 2002 May;8(5):500-8 [11984595.001]
  • [Cites] J Biol Chem. 2002 Feb 8;277(6):4309-16 [11706037.001]
  • [Cites] Nat Cell Biol. 2002 Feb;4(2):170-4 [11802165.001]
  • [Cites] Nat Cell Biol. 2002 Feb;4(2):165-9 [11802164.001]
  • [Cites] J Immunol. 2002 Jan 15;168(2):861-8 [11777983.001]
  • [Cites] J Immunol. 2001 Nov 15;167(10):6015-20 [11698482.001]
  • [Cites] Transplant Proc. 2000 Nov;32(7):1773 [11119928.001]
  • [Cites] J Biol Chem. 2001 Jan 12;276(2):1660-4 [11058597.001]
  • [Cites] J Biol Chem. 2000 Jun 23;275(25):19167-76 [10749887.001]
  • [Cites] J Immunol. 2008 Aug 15;181(4):2799-805 [18684971.001]
  • [Cites] J Exp Med. 2008 May 12;205(5):1063-75 [18411338.001]
  • (PMID = 18928529.001).
  • [ISSN] 1755-7682
  • [Journal-full-title] International archives of medicine
  • [ISO-abbreviation] Int Arch Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2596096
  •  go-up   go-down


73. Yokomine K, Nakatsura T, Senju S, Nakagata N, Minohara M, Kira J, Motomura Y, Kubo T, Sasaki Y, Nishimura Y: Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice. Cancer Sci; 2007 Dec;98(12):1930-5
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice.
  • Heat shock protein (HSP) 105 is overexpressed in various cancers, but is expressed at low levels in many normal tissues, except for the testis.
  • Because Apc(Min/+) mice develop multiple adenomas throughout the intestinal tract by 4 months of age, the mice provide a clinically relevant model of human intestinal tumor.
  • In the present study, we investigated the efficacy of the HSP105-pulsed BM-DC vaccine on tumor regression in the Apc(Min/+) mouse.
  • Western blot and immunohistochemical analyses revealed that the tumors of the Apc(Min/+) mice endogenously overexpressed HSP105.
  • Immunization of the Apc(Min/+) mice with a HSP105-pulsed BM-DC vaccine at 6, 8, and 10 weeks of age significantly reduced the number of small-intestinal polyps accompanied by infiltration of both CD4(+) and CD8(+) T cells in the tumors.
  • Cell depletion experiments proved that both CD4(+) and CD8(+) T cells play a critical role in the activation of antitumor immunity induced by these vaccinations.
  • These findings indicate that the HSP105-pulsed BM-DC vaccine can provide potent immunotherapy for tumors that appear spontaneously as a result of the inactivation of a tumor suppressor gene, such as in the Apc(Min/+) mouse model.
  • [MeSH-major] Adenoma / immunology. Cancer Vaccines. Dendritic Cells / immunology. HSP110 Heat-Shock Proteins / immunology. Intestinal Neoplasms / immunology

  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17892515.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / HSP110 Heat-Shock Proteins; 0 / Hsp105 protein, mouse
  •  go-up   go-down


74. Loffler KA, Biondi CA, Gartside M, Waring P, Stark M, Serewko-Auret MM, Muller HK, Hayward NK, Kay GF: Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. Int J Cancer; 2007 Jan 15;120(2):259-67
SciCrunch. Marmoset Gene list: Data: Gene Annotation .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1.
  • Multiple endocrine neoplasia type 1 (MEN1) is an inherited cancer predisposition syndrome typified by development of tumors in parathyroid, pituitary and endocrine pancreas, as well as less common sites including both endocrine and nonendocrine organs.
  • Deletion or mutation of the tumor suppressor gene MEN1 on chromosome 11 has been identified in many cases of MEN1 as well as in sporadic tumors.
  • Here we describe a mouse model of MEN1 in which tumors were seen in pancreatic islets, pituitary, thyroid and parathyroid, adrenal glands, testes and ovaries.
  • The observed tumor spectrum therefore includes types commonly seen in MEN1 patients and additional types.
  • Pancreatic pathology was most common, evident in over 80% of animals, while other tumor types developed with lower frequency and generally later onset.
  • Tumors of multiple endocrine organs were observed frequently, but progression to carcinoma and metastasis were not evident.
  • Tumors in all sites showed loss of heterozygosity at the Men1 locus, though the frequency in testicular tumors was only 36%, indicating that a different molecular mechanism of tumorigenesis occurs in those Leydig tumors that do not show loss of the normal Men1 allele.
  • Menin expression was below the level of detection in ovary, thyroid and testis, but loss of nuclear menin immunoreactivity was observed uniformly in all pancreatic islet adenomas and in some hyperplastic islet cells, suggesting that complete loss of Men1 is a critical point in islet tumor progression in this model.
  • [MeSH-major] Adenoma / pathology. Disease Models, Animal. Endocrine Gland Neoplasms / pathology. Mice / genetics. Multiple Endocrine Neoplasia Type 1 / pathology. Proto-Oncogene Proteins / genetics
  • [MeSH-minor] Animals. DNA, Neoplasm / analysis. Exons / genetics. Female. Genes, Tumor Suppressor. Male. Peptide Chain Initiation, Translational / genetics


75. Llarena Ibarguren R, Azurmendi Sastre V, Padilla Nieva J, Pertusa Peña C: [Non germinal cell testicular tumors]. Arch Esp Urol; 2005 Dec;58(10):1031-4
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Non germinal cell testicular tumors].
  • [Transliterated title] Tumores no germinales de testículo.
  • OBJECTIVES: We report a review of all patients with testicular tumors undergoing surgery in our Hospital over a 13 year period.
  • There were 151 cases, 50 of them were reported as non germ cell tumors (33%).
  • METHODS/RESULTS: 42% of them were haematopoietic tumors, lymphomas and leukemias.
  • 30% of them were non neoplastic tumors, including vascular tumors and granulomatous orchitis.
  • 12% were identified as Leydig or Sertoli cell tumors.
  • CONCLUSIONS: Non germ cell tumors were more frequent in adults (78%) than in children (22%).
  • [MeSH-major] Testicular Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16482852.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


76. Chan PC, Sills RC, Kissling GE, Nyska A, Richter W: Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice. Arch Toxicol; 2008 Jun;82(6):399-412
Hazardous Substances Data Bank. 2-Methylimidazole .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice.
  • At 2 years, the incidences of thyroid follicular cell hyperplasia, adenoma or carcinoma (combined), as well as follicular mineralization were increased.
  • The incidences of hepatocellular adenoma or carcinoma (combined) in the two highest dose groups of males and females were also increased.
  • The incidences of mixed cell focus in males and females were also significantly increased.
  • In mice, the incidences of thyroid follicular cell hypertrophy and hyperplasia were significantly increased in the high dose males and females.
  • The incidence of thyroid follicular cell adenoma in the 2,500 ppm males was significantly greater than that in the control group.
  • The incidences of hepatocellular adenoma or carcinoma (combined) were significantly increased in all exposed groups of males and in the 2,500 ppm females.
  • Significant increases in incidences were also observed in spleen hematopoietic cell proliferation in both sexes and bone marrow hyperplasia, chronic active inflammation of the epididymis, sperm granuloma, and germinal epithelial atrophy of the testis in males.
  • [MeSH-major] Adenocarcinoma / chemically induced. Adenoma / chemically induced. Carcinogens / toxicity. Imidazoles / toxicity. Liver Neoplasms / chemically induced. Thyroid Neoplasms / chemically induced

  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17924096.001).
  • [ISSN] 0340-5761
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Thyroid Hormones; 693-98-1 / 2-methylimidazole; 9002-71-5 / Thyrotropin; EC 2.4.1.17 / Glucuronosyltransferase
  •  go-up   go-down


77. Saraco N, Berensztein E, Sciara M, de Davila MT, Ciaccio M, Ferrari P, Belgorosky A, Rivarola MA: High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis. Pediatr Dev Pathol; 2006 May-Jun;9(3):181-9
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis.
  • Large cell calcifying Sertoli cell tumors (LCCSCT) are associated with Carney complex and Peutz-Jeghers syndrome.
  • The mechanisms linking these 2 genetic defects to the genesis of this tumor are obscure.
  • Studies of CYP19 (aromatase) and transforming growth factor (TGF)-beta1 messenger RNA (mRNA) abundance, estrogen receptor (ER), TGFbeta1, and TGFbeta type II receptor (R) immunochemistry were carried out in the testis of a patient with this tumor to gain information on possible mechanisms of cell tumor development.
  • Testicular tissue of a prepubertal patient, collected at gonadectomy, was separated into 2 macroscopically distinct fractions: tumoral nodules (Tu) and extratumoral, normal-looking testicular tissue (ExTu).
  • The patient was a 9.5-year-old boy with a 5-year history of bilateral gynecomastia (Tanner stage 4), no pubic hair, incipient genital development, and bilateral testicular nodules.
  • Cell proliferation was estimated by Ki-67 antigen immunochemistry and apoptosis using a modified TUNEL assay.
  • Positive staining of Sertoli cells in Tu was higher than in ExTu.
  • TGFbeta type II R immunostaining was detected in most Sertoli and interstitial cells, but intensity in ExTu was lower than in Tu.
  • No significant difference was detected in the proliferation index, but in Tu, the percentage of Sertoli cells in apoptosis (1.4%) was significantly lower (P<0.01) than in ExTu (14.0%).
  • The congenital gene defects of Carney complex or of Peutz-Jeghers syndrome might trigger a cascade of intracellular events that leads to overexpression of aromatase in Sertoli cells, favoring the development of a LCCSCT.
  • At some point in the evolution of the disease, a mutational event might induce a higher expression of the ER.
  • In this environment, TGFbeta1 might switch from tumor suppressor to oncogenic factor and, along with estrogen-ER complexes, might favor tumor progression by inhibiting apoptosis.
  • [MeSH-major] Aromatase / metabolism. Calcinosis. Receptors, Estrogen / metabolism. Sertoli Cell Tumor. Testicular Neoplasms. Transforming Growth Factor beta / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16944977.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Estrogen; 0 / Transforming Growth Factor beta; EC 1.14.14.1 / Aromatase
  •  go-up   go-down


78. Ulbright TM: The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them. Adv Anat Pathol; 2008 Jan;15(1):18-27
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them.
  • Testicular tumors are both increasing in frequency and disproportionately occur in young men; furthermore, different forms of neoplasm require different treatments.
  • These considerations make the accurate diagnosis of testicular tumors especially important.
  • Many of the critical distinctions involve the differentiation of seminoma from one or more potential mimics because seminoma is not only the most common testicular neoplasm but it is also the only malignant testicular tumor that is commonly treated with radiation, which is ineffective in other malignancies of the testis.
  • For the most part, accurate diagnosis can be achieved by careful light microscopic evaluation, although appropriate immunostains can provide diagnostic assistance if doubt persists.
  • This article discusses a number of clinically important differential diagnoses in the testis that are common sources of misinterpretations.
  • These include: seminoma versus embryonal carcinoma, seminoma versus yolk sac tumor, seminoma versus Sertoli cell tumor, seminoma with syncytiotrophoblast cells versus choriocarcinoma, granulomatous seminoma versus granulomatous orchitis, intertubular seminoma versus orchitis, lymphoma versus seminoma or embryonal carcinoma, dermoid cyst versus teratoma, scar versus regressed germ cell tumor, and "anaplastic" spermatocytic seminoma versus usual seminoma or embryonal carcinoma.
  • [MeSH-major] Diagnostic Errors / prevention & control. Seminoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / pathology. Diagnosis, Differential. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Humans. Male. Sertoli Cell Tumor / diagnosis. Sertoli Cell Tumor / pathology

  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18156809.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
  •  go-up   go-down


79. Ersoy O: Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor. World J Gastroenterol; 2005 Nov 28;11(44):7051-3
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor.
  • Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma.
  • Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor( [7] ).
  • Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP( [10] ).
  • Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man.
  • [MeSH-major] Liver Neoplasms. Sertoli Cell Tumor. Testicular Neoplasms. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Carcinoma, Hepatocellular / blood. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Comorbidity. Humans. Male. Neoplasms, Multiple Primary

  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16437617.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
  • [Other-IDs] NLM/ PMC4717055
  •  go-up   go-down


80. Kumar PV, Shirazi M, Salehi M: A diagnostic pitfall of fine needle aspiration cytology in testicular papillary serous cyst adenoma: a case report. Acta Cytol; 2009 Jul-Aug;53(4):467-70
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A diagnostic pitfall of fine needle aspiration cytology in testicular papillary serous cyst adenoma: a case report.
  • BACKGROUND: Testicular neoplasmns resembling ovarian serous tumors are rarely reported.
  • We describe the first fine needle aspiration biopsy (FNAB) finding of this type of tumor.
  • CASE: A 35-year-old man presented with an enlarged right testis.
  • Based on clinical observation, we hypothesized that it was a malignant tumor.
  • A right radical orchiectomy was performed, and histologic tissue examination was used to diagnose the tumor as a benign papillary serous cystadenoma.
  • CONCLUSION: Papillary serous cystadenoma of the testis is a rare tumor.
  • The cytologic findings of this tumor are confusing and difficult to diagnose.
  • Clusters of epithelial cells with a high nuclear to cytoplasm ratio are mistaken for features of a malignant tumor.
  • [MeSH-major] Biopsy, Fine-Needle. Cystadenoma, Papillary / pathology. Cystadenoma, Serous / pathology. Testicular Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19697740.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


81. National Toxicology Program: Toxicology and carcinogenesis study of glycidol (CAS No. 556-52-5) in genetically modified haploinsufficient p16(Ink4a)/p19(Arf) mice (gavage study). Natl Toxicol Program Genet Modif Model Rep; 2007 Nov;(13):1-81
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The left testis, left epididymis, and left cauda epididymis weights were significantly decreased in 200 mg/kg males; the number of sperm heads per cauda epididymis were also significantly decreased in this group.
  • In the lung, incidences of alveolar/bronchiolar adenoma were significantly increased in 100 mg/kg males and 200 mg/kg females; multiple adenomas were seen in some dosed males.
  • Squamous cell papillomas of the forestomach were seen in one 200 mg/kg male, one 100 mg/kg female, and three 200 mg/kg females.
  • The increased incidences of alveolar/bronchiolar adenomas in male mice were also considered to be related to glycidol administration.
  • There was some evidence of carcinogenic activity of glycidol in haploinsufficient p16(Ink4a)/p19(Arf) female mice based on the occurrence of alveolar/bronchiolar adenoma.
  • [MeSH-major] Adenoma / chemically induced. Carcinogens / toxicity. Epoxy Compounds / toxicity. Histiocytic Sarcoma / chemically induced. Lung Neoplasms / chemically induced. Papilloma / chemically induced. Propanols / toxicity. Stomach Neoplasms / chemically induced

  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • MedlinePlus Health Information. consumer health - Stomach Cancer.
  • Hazardous Substances Data Bank. Glycidol .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18784757.001).
  • [ISSN] 1556-5246
  • [Journal-full-title] National Toxicology Program genetically modified model report
  • [ISO-abbreviation] Natl Toxicol Program Genet Modif Model Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Epoxy Compounds; 0 / Propanols; S54CF1DV9A / glycidol
  •  go-up   go-down


82. Ceccarelli C, Canale D, Battisti P, Caglieresi C, Moschini C, Fiore E, Grasso L, Pinchera A, Vitti P: Testicular function after 131I therapy for hyperthyroidism. Clin Endocrinol (Oxf); 2006 Oct;65(4):446-52
Hazardous Substances Data Bank. TESTOSTERONE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular function after 131I therapy for hyperthyroidism.
  • In the present work we studied the absorbed radiation dose to the testes and testicular function in hyperthyroid men after (131)I treatment.
  • Seventeen of the patients had Graves' disease and two had toxic adenoma.
  • CONCLUSIONS: After (131)I therapy, germinal epithelium and Leydig cell function undergo only marginal changes, which may have some significance in subjects with a pre-existing fertility impairment.
  • [MeSH-major] Hyperthyroidism / physiopathology. Hyperthyroidism / radiotherapy. Iodine Radioisotopes / therapeutic use. Testis / radiation effects

  • MedlinePlus Health Information. consumer health - Hyperthyroidism.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16984236.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 3XMK78S47O / Testosterone
  •  go-up   go-down


83. Masserdotti C, Bonfanti U, De Lorenzi D, Tranquillo M, Zanetti O: Cytologic features of testicular tumours in dog. J Vet Med A Physiol Pathol Clin Med; 2005 Sep;52(7):339-46
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic features of testicular tumours in dog.
  • In this paper, we report on our experience of cytology of fine needle biopsies performed on 92 dogs with testicular tumours during the period from 1998 to 2002.
  • Cytological diagnosis was consistent with seminoma in 20 cases, sertolioma in 16 cases, Leydig cell tumours in 50 cases and mastocytoma in one case.
  • Cytology provided a sensitivity of 95% for seminoma, 88% for sertolioma and 96% for Leydig cell tumours.
  • The specificity was 100% for all three tumour types.
  • In our experience cytology of fine needle aspirations of testicular tumours is a very reliable technique.
  • [MeSH-major] Biopsy, Fine-Needle / veterinary. Dog Diseases / pathology. Testicular Neoplasms / veterinary
  • [MeSH-minor] Animals. Dogs. Italy / epidemiology. Leydig Cell Tumor / pathology. Leydig Cell Tumor / veterinary. Male. Mastocytoma / pathology. Mastocytoma / veterinary. Predictive Value of Tests. Seminoma / pathology. Seminoma / veterinary. Sensitivity and Specificity. Sertoli Cell Tumor / pathology. Sertoli Cell Tumor / veterinary

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16109100.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


84. Vegter AR, Kooistra HS, van Sluijs FJ, van Bruggen LW, Ijzer J, Zijlstra C, Okkens AC: Persistent Mullerian duct syndrome in a Miniature Schnauzer dog with signs of feminization and a Sertoli cell tumour. Reprod Domest Anim; 2010 Jun;45(3):447-52
SciCrunch. OMIA - Online Mendelian Inheritance in Animals: Data: Gene Expression .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent Mullerian duct syndrome in a Miniature Schnauzer dog with signs of feminization and a Sertoli cell tumour.
  • Abdominal ultrasonography revealed an enlarged right testis and a large, fluid-filled cavity that appeared to arise from the prostate.
  • Gonadohysterectomy was performed and both the surgical and the histological findings confirmed the presence of a uterus in this male animal, resulting in a diagnosis of persistent Mullerian duct syndrome (PMDS).
  • The enlarged intra-abdominal testis contained a Sertoli cell tumour.
  • [MeSH-major] Dog Diseases / diagnosis. Feminization / veterinary. Mullerian Ducts. Sertoli Cell Tumor / veterinary
  • [MeSH-minor] Animals. Cryptorchidism / pathology. Cryptorchidism / veterinary. Disorders of Sex Development / diagnosis. Disorders of Sex Development / surgery. Disorders of Sex Development / veterinary. Dogs. Female. Karyotyping / veterinary. Male. Testis / pathology. Tomography, X-Ray Computed. Ultrasonography / veterinary. Uterus / pathology. Uterus / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18954385.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


85. Chierigo P, Puccetti O, Visonà A, Bassan F, Rahmati M, Lazzarotto M, Franzolin N: [High alpha-fetoprotein persistence after orchiectomy. On a case of uncommon etiology]. Urologia; 2010 Oct-Dec;77 Suppl 17:27-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Persistenza di alfa-fetoproteina elevata dopo orchiectomia. Su di un caso ad etiologia inusuale.
  • BACKGROUND: The following report describes a case of inherited elevation of alpha-fetoprotein (AFP) in a young male suspected for testicular cancer.
  • From this age on, serum AFP can rise above normal in some diseases, e.g. liver disorders, and in some kind of tumors.
  • METHODS: An elevated serum AFP (about 20 µg/mL) was found in a 27-year-old white man with an unremarkable medical history, who was concerned to have left testicular cancer.
  • By our examination, his left testis was markedly reduced in size.
  • Surgical inguinal exploration with testis and spermatic cord excision was carried out.
  • Careful evaluation for occult cancer showed no abnormality.
  • Histology showed necrotic tissue and could not make a reliable diagnosis.
  • RESULTS: AFP was found to be elevated in another four out of six relatives within three generations, unrelated to any disease.
  • The existence of this clinically benign condition needs to be considered in both children and adults with unexplained and persistent elevation of AFP, e.g. those diagnosed or suspected for germ cell tumor.
  • [MeSH-major] Metabolism, Inborn Errors / diagnosis. Orchiectomy. alpha-Fetoproteins / analysis
  • [MeSH-minor] Adenoma / complications. Adrenal Gland Neoplasms / complications. Adult. Diagnosis, Differential. Genes, Dominant. Humans. Ischemia / surgery. Male. Neoplasms, Germ Cell and Embryonal / diagnosis. Postoperative Period. Testicular Neoplasms / diagnosis. Testis / blood supply. Testis / pathology. Unnecessary Procedures

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21308671.001).
  • [ISSN] 0391-5603
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / alpha-Fetoproteins
  •  go-up   go-down


86. Zizi-Sermpetzoglou A, Petrakopoulou N, Tepelenis N, Savvaidou V, Manoloudaki K, Katsoulis M: Pure Sertoli cell tumor. a case report and review of the literature. Eur J Gynaecol Oncol; 2010;31(1):117-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pure Sertoli cell tumor. a case report and review of the literature.
  • Pure Sertoli cell tumor (SCT) is a rare sex cord tumor and a subtype of Sertoli-Leydig cell tumors according to the WHO Classification.
  • They lack a Leydig cell component and do not contain the immature neoplastic stroma found in the neoplasms of the Sertoli-Leydig cell category.
  • Sertoli cell tumors occur in women of reproductive age but a few can also occur in children.
  • The tumors are hormone functional in 40-60% of cases.
  • Microscopically they show always almost a tubular growth pattern, but they may also have other growth patterns which can be extensive, making the correct diagnosis difficult.
  • These histologic patterns may result in SCTs mimicking other ovarian tumors.
  • The immunohistochemical panel which usually includes EMA, inhibin, chromogranine, CD99 and calretinin is often helpful in establishing the diagnosis.
  • About 11% of Stage I tumors have worrisome histologic features that may portend an adverse outcome.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sertoli Cell Tumor / pathology

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20349797.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 24
  •  go-up   go-down


87. Tilki D, Kilic N, Herbst H, Reich O, Seitz M, Lauke H, Stief CG, Ergün S: High level of endostatin in epididymal epithelium: protection against primary malignancies in this organ? Histochem Cell Biol; 2008 Sep;130(3):527-35
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rete testis and epididymis are rare locations for primary tumors or metastasis.
  • In situ hybridization and immunohistochemistry for collagen 18 and endostatin were carried out on sections of human rete testis and epididymis as well as on epididymal adenoma and human testicular tissue with or without carcinoma in situ (CIS).
  • In situ hybridization revealed strong expression of collagen 18 mRNA in rete testis, efferent ducts and epididymal duct.
  • Immunostaining showed collagen 18 in epithelium and basement membrane as well as in blood vessels of rete testis.
  • Endostatin immunostaining was localized in the epithelium of rete testis, efferent ducts and epididymal duct.
  • This pattern of endostatin staining was absent in epididymal adenoma tissue while tumor associated blood vessels exhibited strong endostatin staining.
  • High endostatin expression in epididymis may protect this organ against tumor development.
  • Gene therapeutic strategies providing high expression of endostatin in normal epithelia may be useful to prevent tumor development.
  • [MeSH-major] Endostatins / metabolism. Testicular Neoplasms / metabolism. Testicular Neoplasms / pathology
  • [MeSH-minor] Adenoma / metabolism. Basement Membrane. Epididymis / metabolism. Epithelium / metabolism. Gene Expression Regulation. Humans. Male. RNA, Messenger / genetics. Rete Testis / metabolism. Testis / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18478248.001).
  • [ISSN] 0948-6143
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Endostatins; 0 / RNA, Messenger
  •  go-up   go-down


88. Ball BA, Conley AJ, Grundy SA, Sabeur K, Liu IK: Expression of anti-Müllerian hormone (AMH) in the equine testis. Theriogenology; 2008 Mar 15;69(5):624-31
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of anti-Müllerian hormone (AMH) in the equine testis.
  • Anti-Müllerian hormone (AMH) induces regression of Müllerian ducts during male fetal development; in the human male, it is expressed in Sertoli cells during fetal development (and through puberty).
  • The objective was to characterize expression of AMH in the fetal, neonatal, prepubertal, and adult equine testis, as well as in equine cryptorchid testes, in select testicular neoplasms, and in intersex gonads, based upon immunohistochemistry (IHC).
  • In addition, cryptorchid testes, testis tumors (teratomas, seminomas, Sertoli cell tumors), and male intersex gonads were examined by IHC for expression of AMH using a goat polyclonal primary antibody (alpha-AMH) directed against a C-terminal peptide antigen from human AMH.
  • Immunolabeling with alpha-AMH was localized to Sertoli cells within the developing seminiferous tubules of fetal, neonatal and prepubertal equine testes, with no expression detected in Sertoli cells from normal adult equine testes.
  • Furthermore, expression was detected in cryptorchid testes (in animals up to 3-4 years of age) and in Sertoli cell tumors and male intersex gonads.
  • In conclusion, AMH was strongly expressed by Sertoli cells in fetal, neonatal and prepubertal equine testes, but not in normal adult testes.
  • That AMH was expressed in cryptorchid testes may provide a useful biomarker for detection of cryptorchid testes, as well as for immunohistochemical characterization of testicular tumors and intersex gonads in the horse.
  • [MeSH-major] Anti-Mullerian Hormone / biosynthesis. Horses / metabolism. Sertoli Cells / metabolism. Testis / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18242669.001).
  • [ISSN] 0093-691X
  • [Journal-full-title] Theriogenology
  • [ISO-abbreviation] Theriogenology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 80497-65-0 / Anti-Mullerian Hormone
  •  go-up   go-down


89. Oliva E, Garcia-Miralles N, Vu Q, Young RH: CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases. Int J Gynecol Pathol; 2007 Oct;26(4):359-67
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases.
  • CD10 has been recently advocated as a good immunohistochemical marker for endometrial stromal tumors.
  • Metastatic endometrial stromal tumors to the ovary and primary endometrioid stromal sarcomas may show overlapping histological features with pure stromal and sex cord-stromal tumors (SCSTs).
  • We investigated CD10 expression in a large series of pure stromal and SCSTs of the ovary to ascertain whether CD10 may aid in this differential diagnosis.
  • Archival material from 11 fibromas, 10 thecomas, 10 sclerosing stromal tumors (SSTs), 10 adult granulosa cell tumors (AGCTs), 4 luteinized AGCTs, 9 juvenile granulosa cell tumors (JGCTs), 9 Sertoli cell tumors, 9 Sertoli-Leydig cell tumors, 11 sex cord tumors with annular tubules, 10 steroid cell tumors (StCTs), and 8 fibrosarcomas of the ovary were immunostained for CD10.
  • CD10 was expressed in 7 of 10 thecomas (4 with 5%-75% and mostly 1+), 9 of 10 SSTs (7 with 5%-39% + cells, mostly 1+), 9 of 10 AGCTs (<5%-39%, four 1+, five 2+), 1 of 4 luteinized AGCTs (<5% and 1+), 8 of 9 JGCTs (mostly <5% to 39% and +1), 4 of 9 Sertoli cell tumors (either focal or >75% with variable intensity), 4 of 9 Sertoli-Leydig cell tumors (mostly <10% with variable staining), with the Leydig cells being positive in only 1 tumor (1+ and <5%), and 7 of 10 StCTs (4 tumors with more than 75% + cells, from 1+ to 3+).
  • All fibromas, all but 1 fibrosarcoma (<5% and 1+), and all sex cord tumors with annular tubules were CD10 negative.
  • In conclusion the frequency and intensity of CD10 immunoreactivity in pure stromal and sex cord-stromal ovarian tumors are low and contrast with the typical strong and diffuse immunostaining seen in endometrial stromal tumors; however, faint CD10 positivity is consistent with the diagnosis of ovarian SCST.
  • Steroid cell tumors are often positive for CD10, but these tumors do not pose problems in differential diagnosis with endometrial stromal tumors.
  • CD10 may play a useful role in aiding the differential between endometrial stromal tumors in the ovary and SCST and stromal tumors.
  • [MeSH-major] Neprilysin / biosynthesis. Ovarian Neoplasms / metabolism. Sex Cord-Gonadal Stromal Tumors / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Endometrial Stromal Tumors / pathology. Female. Humans. Immunohistochemistry. Pregnancy. Pregnancy Complications, Neoplastic / metabolism. Pregnancy Complications, Neoplastic / pathology

  • MedlinePlus Health Information. consumer health - Ovarian Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17885484.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


90. Doxsee AL, Yager JA, Best SJ, Foster RA: Extratesticular interstitial and Sertoli cell tumors in previously neutered dogs and cats: a report of 17 cases. Can Vet J; 2006 Aug;47(8):763-6
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extratesticular interstitial and Sertoli cell tumors in previously neutered dogs and cats: a report of 17 cases.
  • Primary neoplasms derived from testicular tissue and in an extratesticular location are extremely rare.
  • Clinical and surgical information was collected and verified from 15 different submitting practices for 12 dogs and 5 cats that spontaneously developed neoplasms of testicular origin after castration.
  • Eleven dogs had Sertoli cell tumors in an extratesticular location.
  • One dog and all 5 cats had an extratesticular interstitial cell tumor.
  • Six animals (1 dog, 5 cats) had developed secondary sexual characteristics that reversed after removal of the tumor.
  • No animals died of neoplasia-related disease and no metastases were identified.
  • Several possibilities, including the presence of embryological ectopic tissue or the presence of testicular tissue transplanted during castration, are considered as causal.
  • [MeSH-major] Cat Diseases / pathology. Dog Diseases / pathology. Leydig Cell Tumor / veterinary. Sertoli Cell Tumor / veterinary. Testicular Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Dogs. Immunohistochemistry / veterinary. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / veterinary. Orchiectomy / veterinary. Retrospective Studies. Testis / pathology. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Gene Ther. 2004 Apr;11(8):694-700 [14724669.001]
  • [Cites] Xenotransplantation. 2003 Nov;10(6):577-86 [14708526.001]
  • [Cites] APMIS. 2003 Jan;111(1):174-81; discussion 182-3 [12760377.001]
  • [Cites] Endocr Rev. 2001 Dec;22(6):836-58 [11739336.001]
  • [Cites] Vet Pathol. 2001 Nov;38(6):729-30 [11732812.001]
  • [Cites] J Vet Diagn Invest. 2001 Jul;13(4):328-32 [11478605.001]
  • [Cites] Reproduction. 2001 Feb;121(2):287-96 [11226053.001]
  • [Cites] Mol Cell Endocrinol. 2000 Mar 30;161(1-2):43-6 [10773390.001]
  • [Cites] Vet Rec. 1999 Dec 11;145(24):711-2 [10638803.001]
  • [Cites] Kurume Med J. 1998;45(3):271-8 [9787598.001]
  • [Cites] Vet Pathol. 1993 May;30(3):287-95 [8392765.001]
  • [Cites] J Am Vet Med Assoc. 1993 Jun 1;202(11):1865-6 [8320156.001]
  • [Cites] J Endocrinol. 1990 Nov;127(2):235-42 [2123496.001]
  • [Cites] Cornell Vet. 1989 Jul;79(3):263-6 [2752759.001]
  • [Cites] Acta Anat (Basel). 1979;105(2):188-97 [532547.001]
  • [Cites] J Am Vet Med Assoc. 1973 Dec 15;163(12):1364-8 [4760082.001]
  • [Cites] Mod Vet Pract. 1973 Oct;54(11):69 [4747285.001]
  • [Cites] J Ultrasound Med. 2004 Jul;23(7):951-7 [15292564.001]
  • (PMID = 16933553.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal = La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC1524845
  •  go-up   go-down


91. Ahtiainen P, Rulli SB, Shariatmadari R, Pelliniemi LJ, Toppari J, Poutanen M, Huhtaniemi IT: Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice. Oncogene; 2005 Nov 10;24(49):7301-9
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice.
  • We have previously demonstrated that male transgenic (TG) mice overexpressing human chorionic gonadotropin (hCG+) develop reproductive organ defects, but no tumors, in adult age.
  • Leydig cell (LC) adenomas were found in prepubertal mice, most prominently at the age of 10 days, but not in adult age.
  • Hence, the postnatal adenomas resemble functionally fetal LCs, and only these cells are susceptible to hCG-induced tumorigenesis.
  • [MeSH-major] Adenoma / etiology. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Gene Expression Regulation, Developmental. Glycoprotein Hormones, alpha Subunit / metabolism. Leydig Cells / metabolism
  • [MeSH-minor] 3-Hydroxysteroid Dehydrogenases / metabolism. Animals. Fetus. Gene Expression Regulation, Neoplastic. Humans. Intramolecular Oxidoreductases / metabolism. Lipocalins. Male. Mice. Mice, Transgenic. Phenotype. Testis / metabolism. Testis / pathology. Thrombospondins / metabolism. Up-Regulation

  • COS Scholar Universe. author profiles.
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16007123.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / Glycoprotein Hormones, alpha Subunit; 0 / Lipocalins; 0 / Thrombospondins; 0 / thrombospondin 2; EC 1.1.- / 3-Hydroxysteroid Dehydrogenases; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.2 / prostaglandin R2 D-isomerase
  •  go-up   go-down


92. Tang D, Gorgas K, Zachariou Z: Effects of laparoscopic division of spermatic vessels on histological changes of testes: long-term observation in the model of prepubertal rat. Pediatr Surg Int; 2008 Feb;24(2):213-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During the procedures, the spermatic vessels are ligated and therefore the question of risk related to testicular atrophy is often raised.
  • Laparoscopic SVCD induced testicular spermatogenic arrest in a total of 85% of the operated testes with different severity; 27% of operated testes with mild or severe spermatogenic arrest were seen between puberty and middle age (day 45-540 postoperative), and their size was only slightly reduced.
  • Parallel to the spermatogenic arrest, Leydig cell hyperplasia developed frequently in impaired testes, especially in those without contralateral testes, finally reaching a typical adenoma size.
  • This study showed that laparoscopic SVCD may have high risk in compromising the operated testis.
  • [MeSH-major] Laparoscopy. Testis / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17985133.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


93. van der Putte SC, Toonstra J, Sie-Go DM: Müllerian serous cystadenoma of the scrotum following orchiopexy. Adv Urol; 2009;:610453

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological and immunohistological features were not consistent neither with median raphe cysts or cutaneous adenomas nor with the intrascrotal adenomas of the rete testis, epididymis, nor with (malignant) mesotheliomas.
  • However, the lesion did compare well with serous (papillary) cystadenomas of the testis or paratestis.
  • These adenomas are thought to originate in remnants of the Müllerian system or of peritoneal lining altered by Müllerian metaplasia.
  • This implies that the scrotal adenoma may have developed from an implant of such elements during orchiopexy 14 years ago.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Cutan Pathol. 1992 Aug;19(4):294-301 [1331211.001]
  • [Cites] Mod Pathol. 1997 May;10(5):414-20 [9160304.001]
  • [Cites] Int J Urol. 2004 Dec;11(12):1150-2 [15663695.001]
  • [Cites] Mod Pathol. 2005 Feb;18 Suppl 2:S131-45 [15502808.001]
  • [Cites] Mod Pathol. 2005 Feb;18 Suppl 2:S33-50 [15761465.001]
  • [Cites] Am J Surg Pathol. 2005 Apr;29(4):520-3 [15767808.001]
  • [Cites] Dermatol Online J. 2005;11(3):37 [16409933.001]
  • [Cites] J Am Acad Dermatol. 2006 Nov;55(5 Suppl):S114-5 [17052527.001]
  • [Cites] Int J Urol. 2007 Jun;14(6):573-4; author reply 574 [17593112.001]
  • [Cites] J Urol. 1992 Dec;148(6):1872-3 [1433625.001]
  • [Cites] Am J Surg Pathol. 2001 Mar;25(3):373-8 [11224608.001]
  • [Cites] J Urol. 1976 Apr;115(4):397-400 [1263314.001]
  • (PMID = 19343186.001).
  • [ISSN] 1687-6369
  • [Journal-full-title] Advances in urology
  • [ISO-abbreviation] Adv Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2662405
  •  go-up   go-down


94. Van Cauwelaert Rojas R, Ruiz-Tagle Phillips D, Meneses Ciuffardi M, Carrasco Troncoso AM, Aguirre Aguirre C: [Three cases of unusual non-germ cell tumors of the testicle]. Actas Urol Esp; 2007 Sep;31(8):923-7
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Three cases of unusual non-germ cell tumors of the testicle].
  • By describing 3 clinical cases of unusual testicular non germinal tumors, including an adenoma of the rete testis, an undifferenciated sex cord tumor and a mesothelioma of the tunica vaginalis, we make a literature review of the unusual testicular tumors and testicular apendix, including their incidence and management.
  • Also and as one of our conclusions, we expose the importance of the intraoperatory biopsy in the testicular cancer surgery, because even if it is infrecuent, the presence of this rare testicular tumors, in which if they are proven to be benign, the testicular unit could be preserved and the radical orquiectomy could be avoided.
  • [MeSH-major] Adenoma / pathology. Mesothelioma / pathology. Testicular Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Mesothelioma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18020219.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


95. Vallangeon BD, Eble JN, Ulbright TM: Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses. Am J Surg Pathol; 2010 Dec;34(12):1874-80
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses.
  • Sertoli cell nodules are almost always incidental microscopic lesions found in both cryptorchid and normally descended testes.
  • Sertoli cell nodules, when present as masses or ultrasonographic lesions, may create diagnostic confusion.
  • Herein, we report 6 cases of macroscopic Sertoli cell nodules that were received in consultation.
  • The referral diagnoses included Sertoli cell tumor (2 cases), sex cord tumor with annular tubules (1 case), and gonadoblastoma (1 case).
  • The patients were 19 to 36 years old: 3 patients presented with palpable testicular masses and 3 with lesions that were worrisome for neoplasms in ultrasonographic examinations conducted for pain (2 cases) or infertility (1 case).
  • The Sertoli cell nodules ranged from 6 to 10 mm in diameter and on microscopic examination consisted of circumscribed proliferations of immature Sertoli cells, globules and trabeculae of basement membrane, and spermatogonia in varying proportions.
  • Immunostains for α-inhibin highlighted the Sertoli cells (5 of 5 cases), with the germ cells appearing in negative relief.
  • An antibody for testis-specific protein, Y-encoded (TSPY), stained the spermatogonia (2 of 2 cases), whereas OCT 3/4 was negative in all the cases (5 of 5 cases).
  • We conclude that Sertoli cell nodules may present clinically as mass lesions, and that it is important to distinguish them from true neoplasms to avoid unnecessary procedures.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Gonadoblastoma / diagnosis. Humans. Inhibins / metabolism. Male. Sex Cord-Gonadal Stromal Tumors / diagnosis. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21107095.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
  •  go-up   go-down


96. Ramos-Vara JA, Miller MA: Immunohistochemical evaluation of GATA-4 in canine testicular tumors. Vet Pathol; 2009 Sep;46(5):893-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical evaluation of GATA-4 in canine testicular tumors.
  • GATA-4 is a transcription factor expressed in Sertoli cells and less commonly in Leydig (interstitial) cells but not germ cells in adult human beings, cattle, pigs, and mice.
  • We examined GATA-4 in 76 formalin-fixed, paraffin-embedded canine testicular tumors, including 21 Sertoli cell tumors (SCT), 28 Leydig (interstitial) cell tumors (LCT), 24 seminomas (GCT), and 3 mixed germ cell sex cord-stromal tumors (MGSCT).
  • Our hypothesis was that immunohistochemistry for GATA-4 could discriminate between germ cell and sex cord-stromal tumors of the canine testis.
  • These results indicate that GATA-4 is mainly expressed in sex cord-stromal tumors and not in germ cell tumors of the canine testis.
  • [MeSH-major] Dog Diseases / pathology. GATA4 Transcription Factor / metabolism. Leydig Cell Tumor / pathology. Sertoli Cell Tumor / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Testicular Neoplasms / veterinary

  • MedlinePlus Health Information. consumer health - Testicular Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19429994.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GATA4 Transcription Factor
  •  go-up   go-down


97. Taskinen S, Fagerholm R, Aronniemi J, Rintala R, Taskinen M: Testicular tumors in children and adolescents. J Pediatr Urol; 2008 Apr;4(2):134-7
MedlinePlus Health Information. consumer health - Testicular Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular tumors in children and adolescents.
  • OBJECTIVE: To analyze the spectrum of testicular tumors in children in an unselected population-based series, as well as the results of testis-preserving surgery.
  • PATIENTS AND METHODS: Our hospital database was analyzed for operations for testicular tumors from 1981 to 2006.
  • RESULTS: Thirty-four patients were operated on because of testicular tumors.
  • In 23 (68%) the tumor was benign: benign teratoma (16), Leydig-cell tumor (2), epidermoid cyst (2), Sertoli-cell tumor (1), cystic dysplasia (1), intratesticular focal fibrosis (1).
  • Eleven patients (32%) had a malignant tumor: yolk-sac tumor (6), embryonal carcinoma (5).
  • Twenty out of the 26 (77%) prepubertal boys had a benign tumor in contrast to only three of the eight (38%) adolescent males (P=0.079).
  • Testis-preserving surgery was performed in 10 patients.
  • In eight, the tumor was curatively excised and remaining testis preserved.
  • In one patient who underwent orchiectomy for benign teratoma, two metachronous teratomas were detected in the contralateral testis 6 years after primary surgery.
  • CONCLUSIONS: In children, most testicular tumors are benign, especially before puberty.
  • If testis-preserving surgery is contemplated, complete excision of the tumor should be ascertained.
  • The possibility of metachronous bilateral tumors should be considered in the follow up of testicular teratomas.
  • [MeSH-major] Teratoma / epidemiology. Teratoma / surgery. Testicular Neoplasms / epidemiology. Testicular Neoplasms / surgery
  • [MeSH-minor] Adolescent. Carcinoma, Embryonal / epidemiology. Carcinoma, Embryonal / surgery. Child. Databases, Factual. Endodermal Sinus Tumor / epidemiology. Endodermal Sinus Tumor / surgery. Epidermal Cyst / epidemiology. Epidermal Cyst / surgery. Follow-Up Studies. Humans. Incidence. Leydig Cell Tumor / epidemiology. Leydig Cell Tumor / surgery. Male. Retrospective Studies. Sertoli Cell Tumor / epidemiology. Sertoli Cell Tumor / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18631909.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


98. Auzanneau C, Norez C, Antigny F, Thoreau V, Jougla C, Cantereau A, Becq F, Vandebrouck C: Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel. Biochem Pharmacol; 2008 Jan 15;75(2):476-83
Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.
  • Sertoli cells provide a controlled microenvironment for regulation and maintenance of spermatogenesis for which an acidic milieu is crucial for male fertility.
  • Sertoli cells also contribute to protection of spermatogenetic cells.
  • Here, we showed that TRPV1 is expressed in rat Sertoli cells and regulates an acid sensing Cl(-) channel (ASCC).
  • The expression of TRPV1 in rat Sertoli cells was demonstrated by RT-PCR, immunostaining and calcium measurement experiments.
  • In the human airway epithelial cell line Calu-3 in which ASCC can be detected but not TRPV1, capsaicin and capsazepine were without any effect.
  • Our study provides the first evidence for a regulation by TRPV1 of an acid sensing chloride channel in rat Sertoli cells.
  • TRPV1 and ASCC may thus be considered as new potential physiological regulators of spermatogenesis and targets for pharmacological treatments of reproductive disorders as cryptorchidism, Sertoli cell tumors or torsion of the spermatic cord.
  • [MeSH-major] Chloride Channels / physiology. Sertoli Cells / metabolism. TRPV Cation Channels / physiology

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
  • Hazardous Substances Data Bank. IBUPROFEN .
  • Hazardous Substances Data Bank. CAPSAICIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17945192.001).
  • [ISSN] 0006-2952
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chloride Channels; 0 / TRPV Cation Channels; 0 / Trpv1 protein, rat; LFW48MY844 / capsazepine; S07O44R1ZM / Capsaicin; SY7Q814VUP / Calcium; WK2XYI10QM / Ibuprofen
  •  go-up   go-down


99. Kumanov P, Nandipati KC, Tomova A, Robeva R, Agarwal A: Significance of inhibin in reproductive pathophysiology and current clinical applications. Reprod Biomed Online; 2005 Jun;10(6):786-812
MedlinePlus Health Information. consumer health - Male Infertility.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is a glycoprotein hormone secreted by the Sertoli cells of the testis and granulosa and theca cells of the ovary.
  • Serum inhibin B concentrations are positively related to testicular volume and sperm counts.
  • Current understanding of inhibin physiology and pathology in the human suggests that inhibin B may be of importance as a marker of Sertoli cell function in men with infertility and as a prognostic indicator in women undergoing ovulation induction therapy.
  • Inhibin concentrations are elevated in patients with granulosa cell tumours and in post-menopausal women with mucinous ovarian cancers.
  • Immunoreactivity against the inhibin alpha-subunit was identified in all cases of adrenal cortical adenoma and carcinoma, and levels are suppressed in the malignant prostate disease.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15970011.001).
  • [ISSN] 1472-6483
  • [Journal-full-title] Reproductive biomedicine online
  • [ISO-abbreviation] Reprod. Biomed. Online
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Follistatin; 0 / alpha-Macroglobulins; 104625-48-1 / Activins; 57285-09-3 / Inhibins
  • [Number-of-references] 114
  •  go-up   go-down


100. Wang M, Futamura M, Wang Y, You M: Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Oncogene; 2005 Mar 10;24(11):1958-63
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus.
  • Pas1c1 transcripts were also detected in heart, testis, or brain but not in liver, spleen, or kidney.
  • These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation.
  • [MeSH-major] Adenoma / genetics. Genetic Predisposition to Disease. Lung Neoplasms / genetics. Tumor Suppressor Proteins / genetics






Advertisement