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1. Brazzell JL, Weiss DJ: A retrospective study of aplastic pancytopenia in the dog: 9 cases (1996-2003). Vet Clin Pathol; 2006 Dec;35(4):413-7
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  • Signalment, treatment given, previous and current disease conditions, clinical signs of disease, clinical laboratory data, therapy, response to therapy, and survival time were recorded.
  • Two dogs (22%) had associated diseases that included monocytic ehrlichiosis and Sertoli cell tumor.
  • One dog was living 3 years after diagnosis, but hematologic recovery was never documented.

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  • (PMID = 17123247.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Auzanneau C, Norez C, Antigny F, Thoreau V, Jougla C, Cantereau A, Becq F, Vandebrouck C: Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel. Biochem Pharmacol; 2008 Jan 15;75(2):476-83
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  • [Title] Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.
  • Sertoli cells provide a controlled microenvironment for regulation and maintenance of spermatogenesis for which an acidic milieu is crucial for male fertility.
  • Sertoli cells also contribute to protection of spermatogenetic cells.
  • Here, we showed that TRPV1 is expressed in rat Sertoli cells and regulates an acid sensing Cl(-) channel (ASCC).
  • The expression of TRPV1 in rat Sertoli cells was demonstrated by RT-PCR, immunostaining and calcium measurement experiments.
  • In the human airway epithelial cell line Calu-3 in which ASCC can be detected but not TRPV1, capsaicin and capsazepine were without any effect.
  • Our study provides the first evidence for a regulation by TRPV1 of an acid sensing chloride channel in rat Sertoli cells.
  • TRPV1 and ASCC may thus be considered as new potential physiological regulators of spermatogenesis and targets for pharmacological treatments of reproductive disorders as cryptorchidism, Sertoli cell tumors or torsion of the spermatic cord.
  • [MeSH-major] Chloride Channels / physiology. Sertoli Cells / metabolism. TRPV Cation Channels / physiology

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 17945192.001).
  • [ISSN] 0006-2952
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chloride Channels; 0 / TRPV Cation Channels; 0 / Trpv1 protein, rat; LFW48MY844 / capsazepine; S07O44R1ZM / Capsaicin; SY7Q814VUP / Calcium; WK2XYI10QM / Ibuprofen
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3. Nicoletto MO, Caltarossa E, Donach M, Nardelli GB, Parenti A, Ambrosini A: Sertoli cell tumor: a rare case in an elderly patient. Eur J Gynaecol Oncol; 2006;27(1):86-7
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  • [Title] Sertoli cell tumor: a rare case in an elderly patient.
  • Sertoli-Leydig cell tumors constitute < 1% of ovarian tumors, mostly in young women with virilization; however, not all present endocrine manifestations.
  • The pathologic diagnosis was poorly-differentiated sex cord-stromal tumor with Sertoli cells.
  • At 12-month follow-up the patient showed no evidence of disease.
  • [MeSH-major] Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Sertoli Cell Tumor / pathology. Sertoli Cell Tumor / surgery
  • [MeSH-minor] Age Factors. Aged. Biopsy, Needle. Female. Follow-Up Studies. Humans. Hysterectomy / methods. Immunohistochemistry. Neoplasm Staging. Ovariectomy / methods. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 16550978.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 13
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4. Coelho R, Brito MJ, Casella P, Bragança G, Machado MC: [Microlithiasis and testicular tumour]. Acta Med Port; 2005 Nov-Dec;18(6):485-7
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  • [Title] [Microlithiasis and testicular tumour].
  • [Transliterated title] Microlitíase e tumor testicular.
  • Testicular microlithiasis is a rare entity, usually asymptomatic and bilateral.
  • There are however reports that until 40% of the cases may be related with testicular tumours.
  • We report an 11-year-old boy, with a four-month history of left testicular mass.
  • Sonography showed increased volume of left testis and bilateral microlithiasis.
  • Testicular biopsy revealed Sertoli cell tumour and he was submitted to left radical orquidectomy.
  • Testicular cancer is often curable, especially if diagnosed and treated early.
  • The association of malignancy justifies long term clinical and ultrasound follow-up of testicular microlithiasis.
  • [MeSH-major] Calculi / complications. Sertoli Cell Tumor / complications. Testicular Diseases / complications. Testicular Neoplasms / complications


5. Cao Avellaneda E, Alarcón Martínez H, Fuster Soler JL, López Cubillana P, Llinares Riestra E, Pérez Albacete M: [Testicular and paratesticular prepuberal tumors: our experience and update on the topic]. Actas Urol Esp; 2005 Apr;29(4):355-9
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  • [Title] [Testicular and paratesticular prepuberal tumors: our experience and update on the topic].
  • [Transliterated title] Tumores testiculares y paratesticulares prepuberales. Experiencia en nuestro centro y revisión de la literatura.
  • OBJECTIVES: To evaluate the importance of testicular and paratesticular prepubertal tumors in our center and to make an update on the topic.
  • METHODS AND PATIENTS: Data from all patients diagnosed of testicular and paratesticular prepubertal tumors and treated in our pediatric oncology unit from January 1st 1998 to December 31st 2003 have been revised.
  • RESULTS: Seven cases are reported among one hundred and ninety patients (represents 3,68 percent of all treated tumors): five tumors affecting the testis and two cases of paratesticular tumors.
  • Pathology classification was as follows: one yolk sack tumor, one mature teratoma, two nongerminomatous testicular tumors (one Sertoli cell tumor and one unclassifiable), one Burkitt's lymphoma and two paratesticular rhabdomyosarcomas.
  • CONCLUSIONS: Testicular and paratesticular prepubertal tumors are rare.
  • [MeSH-major] Testicular Neoplasms / pathology

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  • (PMID = 15981422.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas espanolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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6. Oliva E, Garcia-Miralles N, Vu Q, Young RH: CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases. Int J Gynecol Pathol; 2007 Oct;26(4):359-67
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  • [Title] CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases.
  • CD10 has been recently advocated as a good immunohistochemical marker for endometrial stromal tumors.
  • Metastatic endometrial stromal tumors to the ovary and primary endometrioid stromal sarcomas may show overlapping histological features with pure stromal and sex cord-stromal tumors (SCSTs).
  • We investigated CD10 expression in a large series of pure stromal and SCSTs of the ovary to ascertain whether CD10 may aid in this differential diagnosis.
  • Archival material from 11 fibromas, 10 thecomas, 10 sclerosing stromal tumors (SSTs), 10 adult granulosa cell tumors (AGCTs), 4 luteinized AGCTs, 9 juvenile granulosa cell tumors (JGCTs), 9 Sertoli cell tumors, 9 Sertoli-Leydig cell tumors, 11 sex cord tumors with annular tubules, 10 steroid cell tumors (StCTs), and 8 fibrosarcomas of the ovary were immunostained for CD10.
  • CD10 was expressed in 7 of 10 thecomas (4 with 5%-75% and mostly 1+), 9 of 10 SSTs (7 with 5%-39% + cells, mostly 1+), 9 of 10 AGCTs (<5%-39%, four 1+, five 2+), 1 of 4 luteinized AGCTs (<5% and 1+), 8 of 9 JGCTs (mostly <5% to 39% and +1), 4 of 9 Sertoli cell tumors (either focal or >75% with variable intensity), 4 of 9 Sertoli-Leydig cell tumors (mostly <10% with variable staining), with the Leydig cells being positive in only 1 tumor (1+ and <5%), and 7 of 10 StCTs (4 tumors with more than 75% + cells, from 1+ to 3+).
  • All fibromas, all but 1 fibrosarcoma (<5% and 1+), and all sex cord tumors with annular tubules were CD10 negative.
  • In conclusion the frequency and intensity of CD10 immunoreactivity in pure stromal and sex cord-stromal ovarian tumors are low and contrast with the typical strong and diffuse immunostaining seen in endometrial stromal tumors; however, faint CD10 positivity is consistent with the diagnosis of ovarian SCST.
  • Steroid cell tumors are often positive for CD10, but these tumors do not pose problems in differential diagnosis with endometrial stromal tumors.
  • CD10 may play a useful role in aiding the differential between endometrial stromal tumors in the ovary and SCST and stromal tumors.
  • [MeSH-major] Neprilysin / biosynthesis. Ovarian Neoplasms / metabolism. Sex Cord-Gonadal Stromal Tumors / metabolism
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Endometrial Stromal Tumors / pathology. Female. Humans. Immunohistochemistry. Pregnancy. Pregnancy Complications, Neoplastic / metabolism. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 17885484.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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7. Zhao YC, Shi QL, Zhou XJ, Ma HH, Lu ZF, Zhou HB: [Clinicopathological study of primary carcinoid tumor of the testis]. Zhonghua Nan Ke Xue; 2007 Feb;13(2):157-60
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  • [Title] [Clinicopathological study of primary carcinoid tumor of the testis].
  • OBJECTIVE: To study the clinicopathological characteristics, immunohistochemical features and histogenesis of primary testicular carcinoid tumor and its differential diagnosis.
  • METHODS: Light microscopy and immunohistochemical stains were performed in 4 cases of primary testicular carcinoid tumor.
  • RESULTS: The patients sought care for scrotum mass presented from 2 to 36 years, 2 cases accompanied with tender swelling of the testis.
  • The tumors were described as nodular, yellowish-gray in color, 3.0-4.0 cm in the greatest dimensions, and well circumscribed, focal necrosis seen in 1 case.
  • The tumor cells were round or polygonal with regular monomorphic nuclei, stippling chromatin and eosinophilic granular cytoplasm.
  • Immunohistochemical staining for synaptophysin, chromogranin A, NSE and cytokeratin showed diffusely positive expression in the tumor cells.
  • CONCLUSION: Primary testicular carcinoid tumor is extremely rare with good prognosis and its histogenesis remains controversial.
  • Diagnostically it has to be differentiated from seminoma, metastatic carcinoid tumor, Sertoli cell tumor and granulosa cell tumor.
  • [MeSH-major] Carcinoid Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Granulosa Cell Tumor / pathology. Humans. Male. Neoplasm Metastasis. Seminoma / pathology. Sertoli Cell Tumor / pathology


8. Devouassoux-Shisheboran M, Deschildre C, Mauduit C, Berger G, Mejean-Lebreton F, Bouvier R, Droz JP, Fénichel P, Benahmed M: Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors. Oncol Rep; 2006 Aug;16(2):335-40
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  • [Title] Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors.
  • Galectin-3, a beta-galactoside-binding lectin, has been implicated in many human malignancies, but has seldom been studied in human gonads and gonadal tumors.
  • The aim of our study was to investigate galectin-3 mRNA and protein expression in normal ovaries and testes as well as in a variety of 51 gonadal sex cord stromal and germ cell tumors, and two testicular seminomatous and non-seminomatous cell lines, using either real-time PCR or immunohistochemistry.
  • In human testes, galectin-3 is specifically expressed in mature Sertoli cells and Leydig cells, and is absent from fetal and pre-pubertal testes, suggesting a hormone-dependence of this gene.
  • In human ovaries, galectin-3 is absent from granulosa cells, as well as from granulosa cell and Sertoli-Leydig cell tumors, and is not a useful marker in distinguishing granulosa cell from Sertoli-Leydig cell tumors.
  • In testicular tumorigenesis, galectin-3 has a dual function according to the histological type of tumors and their hormone dependency.
  • In malignant testicular Sertoli cell tumors, the expression of galectin-3 is down-regulated while, in benign Leydig cell tumors, this expression is maintained, indicating the possible implication of this gene in the development of more aggressive testicular sex cord stromal tumors.
  • In contrast to sex cord stromal tumors, galectin-3 expression is up-regulated in testicular germ cell tumors.
  • By real-time PCR, we demonstrated a significant elevation of the galectin-3 mRNA level in non-seminomatous testicular germ cell tumors and cell line as compared to normal testes and seminomas (p=0.0432 and p=0.0247, respectively), indicating the possible role of this gene in the non-seminomatous differentiation of germ cell tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Galectin 3 / analysis. Sertoli Cell Tumor / diagnosis. Sex Cord-Gonadal Stromal Tumors / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Male. Ovarian Neoplasms / chemistry. Ovarian Neoplasms / diagnosis. Ovary / chemistry. RNA, Messenger / analysis. Receptors, Androgen / analysis. Reverse Transcriptase Polymerase Chain Reaction. Sertoli Cells / chemistry. Testis / chemistry

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  • (PMID = 16820912.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3; 0 / RNA, Messenger; 0 / Receptors, Androgen
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9. Morelli L, Pusiol T, Piscioli F: [Ovarian oxyphilic Sertoli cell tumor: case report and review of the literature]. Pathologica; 2006 Jun;98(3):184-6
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  • [Title] [Ovarian oxyphilic Sertoli cell tumor: case report and review of the literature].
  • [Transliterated title] Tumore a cellule di Sertoli ossifile dell'ovaio: caso clinico e revisione della letteratura.
  • Ovarian oxyphilic Sertoli cell tumor is a rare neoplasm (only three cases were reported in literature).
  • Pathologist 1 made a diagnosis of endometrioid adenocarcinoma, while Pathologist 2 made the diagnosis of oxyphilic Sertoli cell tumor.
  • He sends the same slides to Pathologist 1, who confirmed his diagnosis.
  • The two different diagnosis set different managements of the lesion for the clinician, but overall they set the pathologist who requested the consultation in a difficult position.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sertoli Cell Tumor / pathology

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  • (PMID = 17036948.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
  • [Number-of-references] 1
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10. Lefevre H, Bouvattier C, Lahlou N, Adamsbaum C, Bougnères P, Carel JC: Prepubertal gynecomastia in Peutz-Jeghers syndrome: incomplete penetrance in a familial case and management with an aromatase inhibitor. Eur J Endocrinol; 2006 Feb;154(2):221-7
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  • Endocrine manifestations in PJS include gynecomastia due to calcified Sertoli cell testicular tumors usually referred to as large-cell calcifying Sertoli cell tumors (LSCT).
  • MAIN OUTCOME MEASURES: Longitudinal measurements of sex-steroids, gonadotropins, Sertoli cell markers and auxological evaluation.
  • RESULTS: The two male siblings with PJS had similar bilateral multifocal testicular calcifications and biochemical evidence of Sertoli cell dysfunction manifested by elevated plasma inhibin-alpha levels.
  • During treatment with anastrozole, estradiol levels, growth and skeletal maturation, as well as Sertoli cell markers (inhibin B, inhibin-alpha and anti-Mullerian hormone) decreased.
  • Moreover, the decrease in Sertoli cell markers during aromatase inhibitor treatment suggests that increased estrogen production is a primary event regulating downstream production of Sertoli cell peptides.
  • Anastrozole is efficient in controlling the clinical features of the disease and should be proposed as an alternative to bilateral orchidectomy, which is often performed in this condition.

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  • (PMID = 16452534.001).
  • [ISSN] 0804-4643
  • [Journal-full-title] European journal of endocrinology
  • [ISO-abbreviation] Eur. J. Endocrinol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / Glycoproteins; 0 / Nitriles; 0 / Testicular Hormones; 0 / Triazoles; 0 / inhibin B; 0 / inhibin-alpha subunit; 2Z07MYW1AZ / anastrozole; 57285-09-3 / Inhibins; 80497-65-0 / Anti-Mullerian Hormone; 9007-49-2 / DNA
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11. Ulbright TM, Amin MB, Young RH: Intratubular large cell hyalinizing sertoli cell neoplasia of the testis: a report of 8 cases of a distinctive lesion of the Peutz-Jeghers syndrome. Am J Surg Pathol; 2007 Jun;31(6):827-35
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  • [Title] Intratubular large cell hyalinizing sertoli cell neoplasia of the testis: a report of 8 cases of a distinctive lesion of the Peutz-Jeghers syndrome.
  • We report the clinical and pathologic features of 8 boys with Peutz-Jeghers syndrome who had distinctive testicular lesions.
  • Physical examination demonstrated bilateral testicular enlargement in the absence of a discrete mass.
  • Testicular biopsy, performed in all cases, usually showed no gross abnormality, but on microscopic examination there were patchily distributed clusters of expanded seminiferous tubules that contained large Sertoli cells with vacuolated to eosinophilic cytoplasm admixed with globular deposits of basement membrane that extended from a thickened peritubular basement membrane.
  • Small, focal calcifications occurred in 3 cases; no invasive tumor was present in any of the cases.
  • Review of the previously reported cases of testicular lesions in Peutz-Jeghers patients verified a low frequency of invasive tumors (27%) and no known case with metastasis.
  • The testicular lesions seen in patients with Peutz-Jeghers syndrome mostly represent multifocal intratubular neoplasia of large Sertoli cells with unique morphology distinct from other lesions such as the large cell calcifying Sertoli cell tumor and sex cord tumor with annular tubules.
  • The process usually remains confined to the tubules for prolonged intervals (years), but it may occasionally progress to invasive large cell Sertoli cell tumors with or without associated calcification.
  • Orchiectomy is indicated when there is evidence of an invasive tumor and may be necessary to control hormonal manifestations.
  • [MeSH-major] Peutz-Jeghers Syndrome / complications. Sertoli Cell Tumor / complications. Sertoli Cell Tumor / pathology. Testicular Neoplasms / complications. Testicular Neoplasms / pathology

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  • (PMID = 17527069.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Teankum K, Hauser B, Grest P, Pospischil A, Janett F, Bürgi E, Borel N: Capillary haemangiomas of the scrotum and testicle in boars. J Comp Pathol; 2008 Nov;139(4):177-86
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  • Of 12 boars with scrotal haemangiomas, three animals also had testicular tumours, as follow: testicular haemangioma (TH) (n=1); TH with intratubular germ cell tumour (ITGT) (n=1); TH with intratubular germ cell-like tumour (ITGLT) and Sertoli cell tumour (n=1).
  • In the nine remaining boars, no testicular tumours were found.
  • Immunohistochemical examination of scrotal and testicular haemangiomas revealed labelling of endothelial cells for vimentin and factor VIII-related antigen.
  • The Sertoli cell tumour was strongly positive for S-100.
  • [MeSH-major] Hemangioma, Capillary / pathology. Hemangioma, Capillary / veterinary. Scrotum / pathology. Swine Diseases / pathology. Testicular Neoplasms / pathology. Testicular Neoplasms / veterinary

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  • (PMID = 18775543.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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13. Matsuu A, Hashizume T, Kanda T, Nagano M, Sugiyama A, Okamoto Y, Hikasa Y: A case of persistent Müllerian duct syndrome with sertoli cell tumor and hydrometra in a dog. J Vet Med Sci; 2009 Mar;71(3):379-81
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  • [Title] A case of persistent Müllerian duct syndrome with sertoli cell tumor and hydrometra in a dog.
  • Upon exploratory laparotomy, two tumors and a connecting structure similar to fluid-filled uterus were recognized.
  • After cytological and bacterial examinations of the fluid and histological examination, this dog was diagnosed with bilateral Sertoli cell tumor with hydrometra.


14. Llarena Ibarguren R, Azurmendi Sastre V, Padilla Nieva J, Pertusa Peña C: [Non germinal cell testicular tumors]. Arch Esp Urol; 2005 Dec;58(10):1031-4
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  • [Title] [Non germinal cell testicular tumors].
  • [Transliterated title] Tumores no germinales de testículo.
  • OBJECTIVES: We report a review of all patients with testicular tumors undergoing surgery in our Hospital over a 13 year period.
  • There were 151 cases, 50 of them were reported as non germ cell tumors (33%).
  • METHODS/RESULTS: 42% of them were haematopoietic tumors, lymphomas and leukemias.
  • 30% of them were non neoplastic tumors, including vascular tumors and granulomatous orchitis.
  • 12% were identified as Leydig or Sertoli cell tumors.
  • CONCLUSIONS: Non germ cell tumors were more frequent in adults (78%) than in children (22%).
  • [MeSH-major] Testicular Neoplasms

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  • (PMID = 16482852.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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15. Jensen KL, Krag L, Boe-Hansen GB, Jensen HE, Lehn-Jensen H: Malignant Sertoli cell tumour in a young Simmenthal bull--clinical and pathological observations. Reprod Domest Anim; 2008 Dec;43(6):760-3
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  • [Title] Malignant Sertoli cell tumour in a young Simmenthal bull--clinical and pathological observations.
  • A case of malignant Sertoli cell tumour in a 29-month-old Simmenthal bull that was hospitalized with a history of severe unilateral scrotal swelling is reported.
  • Histology showed Sertoli cells in tubular structures surrounded by dense fibrous stroma replacing normal testicular tissue.
  • Based on the pathological observations a diagnosis of right-sided malignant Sertoli cell tumour with vascular invasion and hydrocele was established.
  • [MeSH-major] Cattle Diseases / pathology. Sertoli Cell Tumor / veterinary. Testicular Hydrocele / veterinary. Testicular Neoplasms / veterinary
  • [MeSH-minor] Animals. Cattle. Immunohistochemistry / veterinary. Male. Sertoli Cells / pathology

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  • (PMID = 18564312.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Brehm R, Rey R, Kliesch S, Steger K, Marks A, Bergmann M: Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome. Anat Embryol (Berl); 2006 Jun;211(3):223-36
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  • [Title] Mitotic activity of Sertoli cells in adult human testis: an immunohistochemical study to characterize Sertoli cells in testicular cords from patients showing testicular dysgenesis syndrome.
  • During puberty, normal somatic Sertoli cells undergo dramatic morphological changes due to the differentiation of immature pre-Sertoli cells in functionally active adult Sertoli cells.
  • Sertoli cell maturation is accompanied with loss of their mitotic activity before onset of spermatogenesis and loss of pre-pubertal and occurrence of adult immunohistochemical Sertoli cell differentiation markers.
  • Testes of infertile adult patients often exhibit numerous histological signs of testicular dysgenesis syndrome (TDS) such as microliths, Sertoli cell only (SCO) tubules, tubules containing carcinoma in situ and immature seminiferous tubules (Sertoli cell nodules).
  • Sertoli cell tumours, however, are very rare neoplasms possibly due to the fact that the mechanism and temporal origin of neoplastic Sertoli cells underlying Sertoli cell tumourigenesis still remain unknown.
  • To clarify the state of Sertoli cell differentiation in both immature seminiferous tubules of adult patients with TDS and Sertoli cell tumour, we compared the expression of the Sertoli cell differentiation markers vimentin, inhibin-alpha, anti-Muellerian-hormone, cytokeratin 18, M2A-antigen, androgen receptor and connexin43 with that of SCO tubules with hyperplasia.
  • In addition, we demonstrated for the first time the existence of proliferating Sertoli cells by Ki67- and PCNA-immunostaining in Sertoli cell nodules of the adult human testis.
  • Our data indicate that mitotically active Sertoli cells in Sertoli cell nodules will be arrested prior to puberty and, contrary to dogma, do not represent foetal or neonatal cells.
  • Since all markers in Sertoli cell nodules revealed a staining pattern identical to that in neoplastic Sertoli cells, but different to that in Sertoli cells of SCO tubules with hyperplasia, it may be speculated that Sertoli cell tumours in adult men may originate from Sertoli cell nodules.
  • [MeSH-major] Gonadal Dysgenesis / pathology. Mitosis / physiology. Sertoli Cells / cytology. Spermatic Cord / cytology. Testis / cytology
  • [MeSH-minor] Adult. Child. Humans. Immunohistochemistry. Male. Sertoli Cell Tumor / pathology. Syndrome

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  • (PMID = 16429274.001).
  • [ISSN] 0340-2061
  • [Journal-full-title] Anatomy and embryology
  • [ISO-abbreviation] Anat. Embryol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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17. Ersoy O: Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor. World J Gastroenterol; 2005 Nov 28;11(44):7051-3
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  • [Title] Very high alpha-fetoprotein in a young man due to concomitant presentation of hepatocellular carcinoma and Sertoli cell testis tumor.
  • Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma.
  • Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor( [7] ).
  • Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP( [10] ).
  • Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man.
  • [MeSH-major] Liver Neoplasms. Sertoli Cell Tumor. Testicular Neoplasms. alpha-Fetoproteins / metabolism
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Carcinoma, Hepatocellular / blood. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Comorbidity. Humans. Male. Neoplasms, Multiple Primary

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  • (PMID = 16437617.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
  • [Other-IDs] NLM/ PMC4717055
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18. Yearley JH, King N, Liu X, Curran EH, O'Neil SP: Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. Vet Pathol; 2008 Nov;45(6):922-7
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  • [Title] Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature.
  • The animal was castrated, and histologic examination revealed a biphasic sex cord-stromal tumor, with one region resembling Sertoli-cell tumor and one region resembling granulosa-cell tumor, with extensive microfollicular pattern and many Call-Exner bodies.
  • Histologic examination of the abdominal tumor showed multifocal formation of Call-Exner bodies in an otherwise highly dedifferentiated population.
  • Positive immunolabeling for alpha inhibin confirmed the sex cord-stromal origin of the abdominal and paravertebral tumor masses.
  • This case has similarities to malignant testicular granulosa-cell tumor of humans.

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  • (PMID = 18984797.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / K01RR24120; United States / NCRR NIH HHS / RR / T32 RR007000; United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / T32 RR007000-32; United States / NCRR NIH HHS / RR / RR007000-32; United States / NCRR NIH HHS / RR / K01 RR024120
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 37
  • [Other-IDs] NLM/ NIHMS93232; NLM/ PMC2660595
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19. Boldorini R, Bozzola C, Ribaldone R, Tosoni A, Monga G: Pure Sertoli cell tumour of the ovary with Meig's syndrome. Pathology; 2006 Dec;38(6):579-81
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  • [Title] Pure Sertoli cell tumour of the ovary with Meig's syndrome.
  • [MeSH-major] Meigs Syndrome / diagnosis. Ovarian Neoplasms / diagnosis. Sertoli Cell Tumor / diagnosis

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  • (PMID = 17393991.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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20. Childs-Sanford SE, Rassnick KM, Alcaraz A: Carboplatin for treatment of a Sertoli cell tumor in a mallard (Anas platyrhynchos). Vet Comp Oncol; 2006 Mar;4(1):51-6
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  • [Title] Carboplatin for treatment of a Sertoli cell tumor in a mallard (Anas platyrhynchos).
  • A 13-year-old male mallard was diagnosed with a non-resectable Sertoli cell tumor involving the left testis.
  • The tumor reduced in size by 25%, and the duck's clinical condition improved for 12 months.
  • Sertoli cell tumors are rare in birds, and this is the first report, to our knowledge, of attempted chemotherapy treatment in the veterinary literature.

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  • (PMID = 19754829.001).
  • [ISSN] 1476-5829
  • [Journal-full-title] Veterinary and comparative oncology
  • [ISO-abbreviation] Vet Comp Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Masserdotti C, De Lorenzi D, Gasparotto L: Cytologic detection of Call-Exner bodies in Sertoli cell tumors from 2 dogs. Vet Clin Pathol; 2008 Mar;37(1):112-4
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  • [Title] Cytologic detection of Call-Exner bodies in Sertoli cell tumors from 2 dogs.
  • A 14-year-old Italian Griffon and an 11-year-old mixed breed dog were presented to our clinic with monolateral testicular enlargement.
  • In both dogs, a firm, nodular, and nonpainful mass was palpated, and ultrasonographic examination of testicular parenchyma showed a large and irregular nodular area with hyperechogenic features.
  • Fine-needle aspirates of the masses were highly cellular and consisted of populations of large elongated vacuolated cells in sheets and palisades, with finely granular chromatin and prominent nucleoli, consistent with neoplastic Sertoli cells.
  • A variable number of structures also were observed that consisted of a central round area of amorphous, deeply eosinophilic, hyaline material surrounded by a peripheral, rosette-like arrangement of single or multiple rows of Sertoli cells.
  • Histologic sections of the tumors obtained following castration confirmed the diagnosis of Sertoli cell neoplasia and the presence of Call-Exner bodies.
  • Call-Exner bodies, thought to represent an attempt by neoplastic cells to form basement membrane, are seen most frequently in granulosa cell tumors, but are occasionally reported in testicular tumors that contain epithelial elements of sex-cord origin.
  • To our knowledge, this is the first description of Call-Exner bodies in cytologic specimens from dogs, and only the fifth report of their presence in canine testicular neoplasms.

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  • (PMID = 18366553.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Abbas F, Bashir NW, Hussainy AS: Sclerosing Sertoli cell tumor of the testis. J Coll Physicians Surg Pak; 2005 Jul;15(7):437-8
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  • [Title] Sclerosing Sertoli cell tumor of the testis.
  • Sclerosing Sertoli-cell tumor is a rare, sex-cord-stromal tumor of the testis with distinct clinical and pathological features with only 14 such cases reported in contemporary literature.
  • We report such a tumor in a young diabetic and hypertensive male.
  • Pathological examination of right radical orchidectomy specimen was consistent with sclerosing sub-type of Sertoli-cell testicular tumor with no invasion.
  • He remains free of disease recurrence at 6 years following surgery.
  • [MeSH-major] Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Comorbidity. Diabetes Mellitus / epidemiology. Humans. Hypertension / epidemiology. Male. Sertoli Cells / pathology

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  • (PMID = 16197877.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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23. Sassa N, Yoshino Y, Matsukawa Y, Komatsu T, Yoshikawa Y, Yamamoto T, Hattori R, Gotoh M: [Case report of malignant sertoli cell tumor]. Nihon Hinyokika Gakkai Zasshi; 2008 Jul;99(5):656-9
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  • [Title] [Case report of malignant sertoli cell tumor].
  • Malignant sertoli cell tumor is a rare disease and only a few cases have been described previously.
  • We report a terminal case of malignant sertoli cell tumor.
  • A 38-year-old male visited a hospital with a complaint of swelling his left testis.
  • His pathologic diagnosis was suspected seminoma, and all tumor markers (LDH, HCG, AFP) were negative, and CT imaging confirmed clinical stage 1 (pT1N0M0S0).
  • After he underwent a CT guided lymph node biopsy, his pathologic diagnosis was viable embryonal carcinoma.
  • His pathologic diagnosis was viable sertoli cell tumor, malignant type.
  • All tumor markers were negative in his all clinical courses.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Combined Modality Therapy. Fatal Outcome. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Orchiectomy. Organoplatinum Compounds / administration & dosage. Salvage Therapy. Tomography, X-Ray Computed

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  • (PMID = 18697473.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Organoplatinum Compounds; 7673326042 / irinotecan; 8UQ3W6JXAN / nedaplatin; XT3Z54Z28A / Camptothecin
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24. Yu CH, Hwang DN, Yhee JY, Kim JH, Im KS, Nho WG, Lyoo YS, Sur JH: Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. J Vet Sci; 2009 Mar;10(1):1-7
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  • [Title] Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors.
  • Primary testicular tumors are the most common causes of cancer in male dogs.
  • Overall, the majority of canine patients should be cured by testicular surgery.
  • However, tumor markers are not well-known in veterinary medicine.
  • We sought to determine using immunohistochemistry whether the combined human testicular tumor markers (placental alkaline phosphatase, OCT3/4, CD30, alpha-fetoprotein, inhibin-alpha, vimentin, c-KIT, and desmin) are expressed in canine seminomas and Sertoli cell tumors (SCTs).
  • We examined 35 canine testicular tumors, 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas.
  • The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans.
  • All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression.
  • [MeSH-major] Dog Diseases / pathology. Immunohistochemistry / veterinary. Seminoma / veterinary. Sertoli Cell Tumor / veterinary
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Dogs. Male

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  • (PMID = 19255517.001).
  • [ISSN] 1229-845X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2801099
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25. Van Cauwelaert Rojas R, Ruiz-Tagle Phillips D, Meneses Ciuffardi M, Carrasco Troncoso AM, Aguirre Aguirre C: [Three cases of unusual non-germ cell tumors of the testicle]. Actas Urol Esp; 2007 Sep;31(8):923-7
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  • [Title] [Three cases of unusual non-germ cell tumors of the testicle].
  • By describing 3 clinical cases of unusual testicular non germinal tumors, including an adenoma of the rete testis, an undifferenciated sex cord tumor and a mesothelioma of the tunica vaginalis, we make a literature review of the unusual testicular tumors and testicular apendix, including their incidence and management.
  • Also and as one of our conclusions, we expose the importance of the intraoperatory biopsy in the testicular cancer surgery, because even if it is infrecuent, the presence of this rare testicular tumors, in which if they are proven to be benign, the testicular unit could be preserved and the radical orquiectomy could be avoided.
  • [MeSH-major] Adenoma / pathology. Mesothelioma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18020219.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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26. National Toxicology Program: Toxicology and carcinogenesis studies of formamide (Cas No. 75-12-7) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2008 Jul;(541):1-192
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  • The incidence of hepatocellular adenoma or carcinoma (combined) in 80 mg/kg females was significantly increased.
  • The incidences of mineralization of the testicular arteries and testicular tunic were significantly increased in 80 mg/kg males.
  • The incidence of hematopoietic cell proliferation of the spleen was significantly increased in 80 mg/kg males.
  • There was equivocal evidence of carcinogenic activity of formamide in female B6C3F1 mice based on increased incidences of hepatocellular adenoma or carcinoma (combined).
  • Mineralization of the testicular arteries and tunic and hematopoietic cell proliferation of the spleen in male mice were also associated with administration of formamide.
  • [MeSH-minor] Administration, Oral. Animals. Body Weight / drug effects. Bone Marrow / drug effects. Bone Marrow / pathology. Calcinosis / chemically induced. Calcinosis / pathology. Female. Hyperplasia. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Mutagenicity Tests. Rats. Rats, Inbred F344. Spleen / drug effects. Spleen / pathology. Testis / drug effects. Testis / pathology

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  • (PMID = 18716632.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Formamides; 4781T907ZS / formamide
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27. Goynumer G, Kayabasoglu F, Senturk B, Turkgeldi E, Guzin K: Acute abdomen due to rupture of Sertoli cell tumor. Arch Gynecol Obstet; 2010 Mar;281(3):557-9
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  • [Title] Acute abdomen due to rupture of Sertoli cell tumor.
  • PURPOSE: To present a rare case of Sertoli cell tumor that presents with acute abdomen.
  • Frozen pathological study revealed a low-grade sex-cord stromal cell tumor.
  • During 2 years of follow-up, there was no evidence of disease.
  • CONCLUSION: Although rupture of a malignant ovarian tumor is an infrequent cause of acute abdomen, it should be considered in the differential diagnosis of acute abdomen.
  • [MeSH-major] Abdomen, Acute / etiology. Ovarian Neoplasms / complications. Sertoli Cell Tumor / complications

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  • (PMID = 19597832.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Charoniti I, Kavazarakis E, Kontaxaki C, Bonou-Boukouvalea I, Fretzayas A, Stassinopoulou A: Large cell calcifying Sertoli cell tumor of the testis in a boy with brucellosis. Pediatr Int; 2006 Oct;48(5):501-3
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  • [Title] Large cell calcifying Sertoli cell tumor of the testis in a boy with brucellosis.
  • [MeSH-major] Brucellosis / complications. Calcinosis / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications

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  • (PMID = 16970792.001).
  • [ISSN] 1328-8067
  • [Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society
  • [ISO-abbreviation] Pediatr Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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29. Threlfall WR, Robertson JT, Munsterman AS, Oglesbee MJ, Hubbell JA: Theriogenology question of the month. Seminoma, spermatocele, sustentacular cell tumor. J Am Vet Med Assoc; 2005 May 15;226(10):1649-50
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  • [Title] Theriogenology question of the month. Seminoma, spermatocele, sustentacular cell tumor.
  • [MeSH-major] Adenoma / veterinary. Horse Diseases / diagnosis. Neoplasms, Multiple Primary / veterinary. Sertoli Cell Tumor / veterinary. Testicular Neoplasms / veterinary
  • [MeSH-minor] Animals. Diagnosis, Differential. Horses. Male. Seminoma / diagnosis. Seminoma / surgery. Seminoma / veterinary. Spermatocele / diagnosis. Spermatocele / surgery. Spermatocele / veterinary

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  • (PMID = 15906562.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Tang D, Gorgas K, Zachariou Z: Effects of laparoscopic division of spermatic vessels on histological changes of testes: long-term observation in the model of prepubertal rat. Pediatr Surg Int; 2008 Feb;24(2):213-7
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  • During the procedures, the spermatic vessels are ligated and therefore the question of risk related to testicular atrophy is often raised.
  • Laparoscopic SVCD induced testicular spermatogenic arrest in a total of 85% of the operated testes with different severity; 27% of operated testes with mild or severe spermatogenic arrest were seen between puberty and middle age (day 45-540 postoperative), and their size was only slightly reduced.
  • Parallel to the spermatogenic arrest, Leydig cell hyperplasia developed frequently in impaired testes, especially in those without contralateral testes, finally reaching a typical adenoma size.
  • This study showed that laparoscopic SVCD may have high risk in compromising the operated testis.
  • [MeSH-major] Laparoscopy. Testis / surgery

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  • (PMID = 17985133.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
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31. Iwamoto I, Yanazume S, Fujino T, Yoshioka T, Douchi T: Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. Gynecol Oncol; 2005 Mar;96(3):870-2
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  • [Title] Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome.
  • Testicular tumors often develop in patients with AIS, Sertoli cell tumor and seminoma being the most common types.
  • Leydig cell tumor in AIS is extremely rare.
  • CASE: A large abdominal tumor developed in a 73-year-old female patient.
  • The patient underwent the extirpation of bilateral gonads including the tumor, pelvic lymph nodes, omentum and appendix vermiformis.
  • The pathological diagnosis was malignant Leydig cell tumor of the left testis.
  • The patient showed no evidence of disease at the post-operative 1 month checkup.
  • CONCLUSION: We reported an extremely rare case of malignant Leydig cell tumor developing in an elderly AIS patient.
  • [MeSH-major] Androgen-Insensitivity Syndrome / complications. Leydig Cell Tumor / complications. Ovarian Neoplasms / complications


32. Halat SK, Ponsky LE, MacLennan GT: Large cell calcifying Sertoli cell tumor of testis. J Urol; 2007 Jun;177(6):2338
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  • [Title] Large cell calcifying Sertoli cell tumor of testis.
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 17509353.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 3
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33. Mardi K, Sharma J: Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis. Indian J Pathol Microbiol; 2008 Jan-Mar;51(1):70-1
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  • [Title] Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis.
  • A 9-year-old boy who presented with a left scrotal swelling was subsequently diagnosed as retiform sertoli cell tumor of testis which consisted entirely of retiform pattern.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male

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  • (PMID = 18417863.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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34. Tilki D, Kilic N, Herbst H, Reich O, Seitz M, Lauke H, Stief CG, Ergün S: High level of endostatin in epididymal epithelium: protection against primary malignancies in this organ? Histochem Cell Biol; 2008 Sep;130(3):527-35
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  • Rete testis and epididymis are rare locations for primary tumors or metastasis.
  • In situ hybridization and immunohistochemistry for collagen 18 and endostatin were carried out on sections of human rete testis and epididymis as well as on epididymal adenoma and human testicular tissue with or without carcinoma in situ (CIS).
  • In situ hybridization revealed strong expression of collagen 18 mRNA in rete testis, efferent ducts and epididymal duct.
  • Immunostaining showed collagen 18 in epithelium and basement membrane as well as in blood vessels of rete testis.
  • Endostatin immunostaining was localized in the epithelium of rete testis, efferent ducts and epididymal duct.
  • This pattern of endostatin staining was absent in epididymal adenoma tissue while tumor associated blood vessels exhibited strong endostatin staining.
  • High endostatin expression in epididymis may protect this organ against tumor development.
  • Gene therapeutic strategies providing high expression of endostatin in normal epithelia may be useful to prevent tumor development.
  • [MeSH-major] Endostatins / metabolism. Testicular Neoplasms / metabolism. Testicular Neoplasms / pathology
  • [MeSH-minor] Adenoma / metabolism. Basement Membrane. Epididymis / metabolism. Epithelium / metabolism. Gene Expression Regulation. Humans. Male. RNA, Messenger / genetics. Rete Testis / metabolism. Testis / metabolism

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  • (PMID = 18478248.001).
  • [ISSN] 0948-6143
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Endostatins; 0 / RNA, Messenger
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35. Demirović A, Džombeta T, Tomas D, Spajić B, Pavić I, Hudolin T, Milošević M, Cupić H, Krušlin B: Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma. Pathol Res Pract; 2010 Oct 15;206(10):695-9
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  • [Title] Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma.
  • The distinction between renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC), especially the eosinophilic variant, can often be difficult.
  • Our study has documented for the first time the expression of MAGE-A3/4 and NY-ESO-1 cancer testis antigens (CTAs) in these tumors.
  • The difference in MAGE-A3/4 expression between two tumor groups was significant (P=0.0013).
  • The difference in NY-ESO-1 expression between two tumor groups was also significant (P=0.0008).
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / immunology. Immunohistochemistry. Membrane Proteins / analysis. Neoplasm Proteins / analysis
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / immunology. Adenoma, Oxyphilic / pathology. Aged. Aged, 80 and over. Croatia. Diagnosis, Differential. Female. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / immunology. Kidney Neoplasms / pathology. Male. Middle Aged. Predictive Value of Tests


36. Onida GA, Bosincu L, Dessole S, Nicolae A, Preda O, Cossu-Rocca P, Aneiros-Fernandez J, Nogales FF: Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma. Int J Gynecol Pathol; 2010 Sep;29(5):423-6
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  • [Title] Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma.
  • The gonadoblastoma on both sides underwent synchronous neoplastic transformation, into a stage I germinoma in the right streak gonad and a highly differentiated Sertoli cell tumor in the left one.
  • The latter was associated with a myriad of microscopic, Sertoli cell implants on the peritoneal surface, which were considered benign as they had a high grade of differentiation, minimal proliferative activity, and an absence of invasion.
  • [MeSH-major] Gonadoblastoma / pathology. Neoplasms, Multiple Primary / pathology. Sertoli Cell Tumor / pathology. Urogenital Neoplasms / pathology

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  • (PMID = 20736766.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Garg M, Kanojia D, Suri S, Gupta S, Gupta A, Suri A: Sperm-associated antigen 9: a novel diagnostic marker for thyroid cancer. J Clin Endocrinol Metab; 2009 Nov;94(11):4613-8
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  • CONTEXT: Cancer-testis antigens are the unique class of testis proteins expressed in tumor but not healthy tissue except testis and might represent ideal targets for the development of novel diagnostics and therapeutic methods in thyroid cancer, which is the most common malignancy of the endocrine system.
  • OBJECTIVE: Our objective was to investigate the clinical relevance of cancer-testis antigen sperm-associated antigen 9 (SPAG9) as early diagnostic and therapeutic target in thyroid cancer.
  • DESIGN, SETTING, AND SUBJECTS: SPAG9 gene and protein expression was determined in thyroid cancer cell lines in 138 thyroid tumor specimens, 60 adjacent noncancerous tissues (ANCT), 22 multinodular goiters (nonneoplastic hyperplasia), and 20 follicular adenoma tissue samples by RT-PCR, in situ RNA hybridization, and immunohistochemistry.
  • RESULTS: SPAG9 mRNA and protein expression was detected in 78% of the thyroid cancer patients but not multiple goiters and follicular adenoma disease patients.
  • Small interfering RNA-mediated knockdown of SPAG9 expression in thyroid cancer cell significantly reduced cellular growth and colony formation.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Biomarkers, Tumor / genetics. Thyroid Neoplasms / genetics
  • [MeSH-minor] Cell Division. Cell Line, Tumor. Enzyme-Linked Immunosorbent Assay. Gene Expression Regulation, Neoplastic. Goiter / blood. Humans. Immunohistochemistry. Neoplasm Staging. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 19820019.001).
  • [ISSN] 1945-7197
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / SPAG9 protein, human
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38. National Toxicology Program: Toxicology and carcinogenesis studies of divinylbenzene-HP (Cas No. 1321-74-0) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2006 Nov;(534):1-290
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  • In addition, the relative weights of the heart and testis were significantly increased in 200 and 400 ppm males.
  • Incidences of degeneration of the olfactory epithelium in 200 and 400 ppm rats and basal cell hyperplasia of the olfactory epithelium in rats exposed to 100 ppm or greater were significantly increased.
  • Following combined analysis of single and step-section data, the incidences of renal tubule adenoma and adenoma or carcinoma (combined) were marginally higher in 200 and 400 ppm males, and the incidence of renal tubule hyperplasia was significantly increased in 400 ppm males.
  • The incidences of malignant glial cell tumors (malignant astrocytoma and oligodendroglioma) in the brain were slightly increased in 100 and 200 ppm males, and the incidence in the 200 ppm group exceeded the historical range for chamber controls.
  • The incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) in 100 ppm males were greater than chamber control incidences, but the incidences of adenoma or carcinoma (combined) were within the historical control range.
  • The incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) in all exposed groups of females were generally greater than those of the chamber controls; the incidences were at the upper end or exceeded the historical control ranges.
  • CONCLUSIONS: Under the conditions of this 2-year inhalation study, there was equivocal evidence of carcinogenic activity of divinylbenzene-HP in male F344/N rats based upon the occurrence of carcinomas in the kidney and glial tumors in the brain.
  • There was equivocal evidence of carcinogenic activity of divinylbenzene-HP in female B6C3F1 mice based on the incidences of alveolar/bronchiolar adenoma or carcinoma (combined) in the lung.

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  • (PMID = 17342197.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vinyl Compounds; IZ715T4SBU / divinyl benzene
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39. Cao D, Li J, Guo CC, Allan RW, Humphrey PA: SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol; 2009 Jul;33(7):1065-77
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  • [Title] SALL4 is a novel diagnostic marker for testicular germ cell tumors.
  • The diagnosis of testicular germ cell tumors (GCTs) sometimes can be challenging without ancillary markers.
  • Here we performed an immunohistochemical study of a novel stem cell marker SALL4 in a large series of 110 primary testicular GCTs (65 pure and 45 mixed) containing the following types of tumors and/or tumor components: 50 intratubular germ cell neoplasias (ITGCNs), 62 classic seminomas, 2 spermatocytic seminomas, 39 embryonal carcinomas (EC), 5 pediatric and 26 postpubertal yolk sac tumors (YST), 7 pediatric and 25 postpubertal teratomas, and 5 choriocarcinomas.
  • To test SALL4 specificity, 23 testicular non-GCTs (10 Leydig cell tumors, 4 Sertoli cell tumors, 3 adenomatoid tumors, 3 paratesticular rhabdomyosarcomas, 2 diffuse large B-cell lymphomas, and 1 rete testis papillary cystadenoma) and 275 nontesticular tumors (158 metastatic carcinomas, 12 metastatic melanomas, 11 primary and 2 metastatic mesotheliomas, and 72 primary and 20 metastatic sarcomas) were also stained for SALL4.
  • All ITGCNs, classic seminomas, and ECs demonstrated strong SALL4 and OCT4 staining in more than 90% tumor cells.
  • All 31 YSTs (5 pediatric and 26 postpubertal) showed strong positive SALL4 staining in more than 90% tumor cells but had negative OCT4 staining.
  • Both spermatocytic seminomas showed positive SALL4 staining in 80% to 95% tumor cells in all 3 types of tumor cells with weak-to-moderate staining intensity.
  • No SALL4 staining was seen in all 23 testicular non-GCTs.
  • Of 275 nontesticular tumors, only 10 carcinomas and 1 sarcoma showed focal (<25% tumor cells) weak SALL4 staining.
  • The only non-neoplastic cells within the testis stained with SALL4 were spermatogonia and few primary spermatocytes.
  • Although all 31 YSTs showed glypican-3 staining, 14 (45%) show staining in less than 30% tumor cells.
  • Our findings indicate that SALL4 is a novel sensitive and relatively specific marker for testicular GCTs.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Germ Cell and Embryonal / diagnosis. Testicular Neoplasms / diagnosis. Transcription Factors / biosynthesis

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  • (PMID = 19390421.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / SALL4 protein, human; 0 / Transcription Factors
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40. Treiyer A, Blanc G, Stark E, Haben B, Treiyer E, Steffens J: Prepubertal testicular tumors: frequently overlooked. J Pediatr Urol; 2007 Dec;3(6):480-3
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  • [Title] Prepubertal testicular tumors: frequently overlooked.
  • OBJECTIVE: Prepubertal testicular tumors are fundamentally distinct from their adult counterparts.
  • We reviewed our 10-year, two-institution experience with respect to diagnosis and treatment.
  • MATERIAL AND METHODS: A retrospective review was performed of all testicular tumors diagnosed between 1996 and 2006 in males younger than 14 years.
  • RESULTS: Of 15 primary testicular tumors, eight (53%) were germ-cell tumors (three teratomas, two yolk sac tumors, one seminoma, one embryonic carcinoma and one choriocarcinoma), four (27%) tumor-like lesions (epidermoid cysts), two (13%) gonadal stromal tumors (a Leydig and a Sertoli cell tumor), and one (7%) gonadoblastoma with gonadal dysgenesis.
  • All boys were presented with a painless scrotal mass and four (27%) of them with elevated tumor markers.
  • Twelve children (80%) were treated with radical orchiectomy and three (20%) with a testis-sparing procedure.
  • At a mean 4-year follow-up no patient has presented with recurrent tumor in the residual or contralateral testicle.
  • Postoperative physical examination and scrotal ultrasound were obtained in 14 patients at a median follow-up of 48.2 months, and there was no evidence of tumor progression.
  • CONCLUSIONS: Benign teratoma and epidermoid cysts were the most common prepubertal testicular tumors.
  • Any suspicion of a testicular tumor warrants an inguinal approach to prevent scrotal violation of the tumor.
  • Our limited experience with testis-sparing procedures supports the current trends that organ-confined surgery should be performed for benign lesions such as teratoma, Leydig cell tumor and epidermoid cysts based on frozen biopsy findings.

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  • (PMID = 18947799.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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41. Zhao C, Bratthauer GL, Barner R, Vang R: Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis. Int J Gynecol Pathol; 2007 Jan;26(1):1-9
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  • [Title] Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis.
  • The distinction of ovarian Sertoli cell tumor from other tumors in the histological differential diagnosis, particularly endometrioid carcinoma and carcinoid tumor, may be difficult.
  • Many immunohistochemical markers have been studied for this differential diagnosis, but currently available markers are neither 100% sensitive nor specific.
  • Sox9 is a transcription factor involved in Sertoli cell differentiation in the testis.
  • The role that this molecule plays in the pathogenesis of ovarian Sertoli cell tumors and the potential use as an immunohistochemical marker for differential diagnosis have not been investigated.
  • Immunohistochemical staining for Sox9 was performed in 152 ovarian tumors: pure Sertoli cell tumor (n = 36), endometrioid borderline tumor (n = 38), well-differentiated endometrioid carcinoma (n = 26), sertoliform endometrioid carcinoma (n = 13), and carcinoid tumor (n = 39).
  • Sox9 was expressed in 44% of Sertoli cell tumors, 55% of endometrioid borderline tumors, 65% of well-differentiated endometrioid carcinomas, 39% of sertoliform endometrioid carcinomas, and 10% of carcinoid tumors.
  • The mean Sox9 immunohistochemical composite scores in positive cases were 6.3 for Sertoli cell tumor, 5.3 for endometrioid borderline tumor, 8.0 for well-differentiated endometrioid carcinoma, 2.8 for sertoliform endometrioid carcinoma, and 6.8 for carcinoid tumor.
  • The differences in the mean Sox9 composite scores between Sertoli cell tumor and the other tumor categories were not statistically significant (p values ranged from 0.092 to 0.523).
  • We conclude that Sox9 is variably expressed in ovarian Sertoli cell tumor and other tumors that are in the differential diagnosis and, thus, is not helpful for immunohistochemical distinction.
  • Understanding the role of Sox9 in the pathogenesis of ovarian Sertoli cell tumor requires further study.
  • [MeSH-major] High Mobility Group Proteins / analysis. High Mobility Group Proteins / metabolism. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / metabolism. Sertoli Cell Tumor / diagnosis. Sertoli Cell Tumor / metabolism. Transcription Factors / analysis. Transcription Factors / metabolism
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / metabolism. Cell Differentiation. Diagnosis, Differential. Female. Humans. Immunohistochemistry. SOX9 Transcription Factor

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  • (PMID = 17197889.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / High Mobility Group Proteins; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / Transcription Factors
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42. Ding XL, Sun AJ, Zhou YZ, Tian QJ, Yu Q, He FF, Shen K, Lang JH: [Identification of potential neoplastic risk in gonadal development abnormality with Y chromosome of 79 cases]. Zhonghua Fu Chan Ke Za Zhi; 2008 Jun;43(6):442-4
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  • [Title] [Identification of potential neoplastic risk in gonadal development abnormality with Y chromosome of 79 cases].
  • OBJECTIVE: To identify the potential neoplastic risk in gonadal development abnormality with Y chromosome.
  • RESULTS: Among 41 cases of androgen insensitive syndrome, spermatogenic cell neoplasm occurred in 1 patient, sertoli cell tumor in 2, and interstitial cell hyperplasia in 5.
  • Among 14 cases of 17 alpha-hydroxylase deficiency (XY) syndrome, one was sertoli cell tumor, and one was sertoli cell hyperplasia.
  • One of 16 cases of XO/XY gonadal dysgenesis was spermatogenic cell neoplasm with agenda cell tumor.
  • All of the gonadoblastoma and germ-cell tumor were located in the pelvis.
  • Tumors occurred mostly during 15 years of age to 32 years.
  • CONCLUSIONS: The gonads of XY pure gonadal dysgenesis has high risks of gonadoblastoma and germ-cell tumor.

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  • (PMID = 19035140.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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43. Kawakami E, Hirano T, Hori T, Tsutsui T: Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis. J Vet Med Sci; 2007 Dec;69(12):1259-62
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  • [Title] Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
  • The proportions of Sertoli cell tumor (SCT), seminoma and Leydig cell tumor in 50 dogs with unilateral testicular tumors were 52%, 36% and 12%, respectively.
  • The rate of occurrence of SCT in the cryptorchid testis was very high (71%).
  • The testicular superoxide dismutase (SOD) activity, testicular heat shock protein (HSP) 70 concentration and peripheral blood plasma inhibin (INH)-alpha concentration of 10 dogs with a unilateral cryptorchid testis and no testicular tumors, 10 dogs with SCT in a unilateral cryptorchid testis and 10 normal dogs, all aged 5-15 years, were measured in order to identify high risk factors for the occurrence of SCT in the canine cryptorchid testis.
  • The low SOD activity in the cryptorchid testis, low blood plasma INH-alpha concentration of the cryptorchid dogs and high HSP 70 concentration in the SCTs may be related to the occurrence of SCT and tumor cell proliferation in canine cryptorchid testes.

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  • (PMID = 18176022.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / HSP70 Heat-Shock Proteins; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 1.15.1.1 / Superoxide Dismutase
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44. Hummel M, Schaaf L, Füchtenbusch M, Standl E, Ziegler A: [62 year-old patient with rapid progressive edema, low potassium and hypertension]. Internist (Berl); 2006 Apr;47(4):427, 429-33
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  • Primary neoplasm is a small cell cancer.
  • A Sertoli-cell-tumor of the testis was diagnosed as an additional carcinoma.
  • [MeSH-major] Cushing Syndrome / etiology. Edema / etiology. Hypertension / etiology. Hypokalemia / etiology. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Humans. Male. Middle Aged


45. You S, Ohmori M, Peña MM, Nassri B, Quiton J, Al-Assad ZA, Liu L, Wood PA, Berger SH, Liu Z, Wyatt MD, Price RL, Berger FG, Hrushesky WJ: Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol; 2006 Jun;87(3):227-36
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  • Collectively, these data suggest that, in addition to its obvious effects upon intestinal adenoma formation, Apc gene mutation causes impairment of developmental and apparent differentiation blockade in proliferative tissues, including those of the haematopoietic system, lymphoid and reproductive tract.

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  • (PMID = 16709231.001).
  • [ISSN] 0959-9673
  • [Journal-full-title] International journal of experimental pathology
  • [ISO-abbreviation] Int J Exp Pathol
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR017698; United States / NCRR NIH HHS / RR / P20RR17698-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2517368
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46. Azurmendi Arín I, Llarena Ibarguren R, Rodríguez JG, Olano Grasa I, Cantón Aller E, Pertusa Peña C: [Sertoli cell malignant tumor]. Arch Esp Urol; 2008 Sep;61(7):834-7
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  • [Title] [Sertoli cell malignant tumor].
  • [Transliterated title] Tumor de células de Sertoli maligno.
  • OBJECTIVE: We report a new case of Sertoli cell testicular tumor with malignant characteristics.
  • METHODS: 77 year-old male patient, suffering a general wasting syndrome presenting with a left solid testicular mass with the diagnosis of malignant Sertoli cell tumor after orchyectomy, without local, regional or distant dissemination, and a benign outcome after 18 months of follow-up.
  • RESULTS: Sertoli cell tumor or androblastoma is classified as non-germ cell tumor derived from the stroma of the sexual cords.
  • There are three types depending on its cellular composition: calcified big cell, sclerotic cell, and the most frequent of all, the classic type.
  • CONCLUSIONS: Being the Sertoli cell testicular tumor rare, its malignant type is even rarer, accounting for not more than 10% of all.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 18972923.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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47. Sato K, Ueda Y, Sakurai A, Ishikawa Y, Okamoto SY, Ikawa H, Katsuda S: Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. Pathol Int; 2005 Jun;55(6):366-71
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  • [Title] Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor.
  • Large cell calcifying Sertoli cell tumor is a rare type of testicular tumor.
  • Reported herein is a Japanese patient with this tumor not associated with Carney's complex.
  • An 11-year-old boy was admitted to hospital because of left testicular enlargement, and radical orchiectomy was performed.
  • Macroscopically, the tumor was well circumscribed and had a maximum diameter of approximately 2 cm.
  • Histologically, the tumor was composed of large neoplastic cells with abundant eosinophilic cytoplasm with a tubular, trabecular, and solid arrangement and loose myxoid stroma with irregularly shaped calcification.
  • Immunohistochemically, the tumor cells were positive for vimentin, S-100 protein, calretinin, inhibin-alpha, melan-A, and CD10, and type IV collagen and laminin were observed in the extracellular matrix around the tumor cells.
  • The distributions of melan-A, CD10, and mitochondria were characteristically patchy; in contrast, they were diffusely distributed in the cytoplasm in a control case of Leydig cell tumor.
  • The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor.
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Antigens, Neoplasm. Calbindin 2. Child. Collagen Type V / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Inhibins / analysis. MART-1 Antigen. Male. Microscopy, Electron. Neoplasm Proteins / analysis. Neprilysin / analysis. S100 Calcium Binding Protein G / analysis. S100 Proteins / analysis. Testis / chemistry. Testis / pathology. Testis / ultrastructure. Vimentin / analysis

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  • (PMID = 15943795.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / Collagen Type V; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Neoplasm Proteins; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins; EC 3.4.24.11 / Neprilysin
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48. Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A: Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status. J Clin Endocrinol Metab; 2006 May;91(5):1779-84
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  • [Title] Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status.
  • Cushing's disease and adrenal and ectopic Cushing's syndrome.
  • MATERIALS AND METHODS: Eighty consecutive patients and 80 controls were prospectively enrolled: 37 patients (21 females) with pituitary ACTH-secreting adenoma, 18 (14 females) with adrenocortical adenoma, 15 (11 females) with adrenal carcinoma of mixed secretion, and 10 (three females) with ectopic ACTH secretion.
  • At diagnosis, bone mineral density (BMD) was determined by the dual-energy x-ray absorptiometry technique at the lumbar spine (L1-L4) and femoral neck; vertebral fractures were investigated by standard spinal radiographs.
  • [MeSH-major] Bone Demineralization, Pathologic / etiology. Hydrocortisone / blood. Ovary / physiopathology. Spinal Fractures / etiology. Testis / physiopathology
  • [MeSH-minor] Adenoma / blood. Adolescent. Adrenal Gland Neoplasms / blood. Adrenocorticotropic Hormone / blood. Adult. Aged. Biomarkers. Body Mass Index. Carcinoma / blood. Case-Control Studies. Cross-Sectional Studies. Female. Humans. Male. Middle Aged. Prospective Studies. Risk Factors

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  • (PMID = 16522701.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 9002-60-2 / Adrenocorticotropic Hormone; WI4X0X7BPJ / Hydrocortisone
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49. Yánez Benítez CJ, Valero Valdivieso C, Sanz Vélez JI, Marigil Gómez M: [Sclerosing sertoli cell tumor. An unfrequent type of testicular neoplasm]. Actas Urol Esp; 2010 Sep;34(8):732-4
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  • [Title] [Sclerosing sertoli cell tumor. An unfrequent type of testicular neoplasm].
  • [Transliterated title] Tumor de celulas de sertoli esclerosante. Un subtipo infrecuente de neoplasia testicular.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 20800040.001).
  • [ISSN] 1699-7980
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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50. McCluggage WG, McKenna M, McBride HA: CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. Int J Gynecol Pathol; 2007 Jul;26(3):322-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors.
  • Ovarian sex cord-stromal tumors comprise a heterogeneous group of neoplasms with wide morphological diversity, and they can be mistaken for a variety of other tumors.
  • Some types, including granulosa and Sertoli cell tumor, may be confused with a neuroendocrine neoplasm.
  • CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and is commonly used as part of a panel to distinguish between a neuroendocrine neoplasm and other tumors in the differential diagnosis.
  • In this study, we investigate CD56 staining in ovarian sex cord-stromal tumors.
  • Neoplasms studied were adult granulosa cell tumor (n = 40), juvenile granulosa cell tumor (n = 8), Sertoli cell tumor (n = 1), Sertoli-Leydig cell tumor (n = 14), Leydig cell tumor (n = 2), steroid cell tumor, not otherwise specified (n = 2), sclerosing stromal tumor (n = 1), sex cord tumor with annular tubules (n = 2), and fibroma (n = 15).
  • Three uterine tumors resembling ovarian sex cord tumor were also studied.
  • Nonneoplastic ovaries, including 3 cases of pregnancy-related granulosa or Sertoli cell proliferation, were also included.
  • All sex cord-stromal tumors except one were positive with CD56; staining ranged from focal to diffuse but was usually diffuse involving more than 50% of tumor cells.
  • CD56 immunoreactivity is almost universal in ovarian sex cord-stromal tumors of all the major morphological types and is of no value in distinguishing a sex cord-stromal and a neuroendocrine neoplasm.
  • Since CD56 is an extremely sensitive marker of ovarian sex cord-stromal tumors, it may be useful in the diagnosis of this group of neoplasms, especially in cases which are alpha inhibin or calretinin negative, and in distinguishing these from mimics which are CD56 negative.
  • [MeSH-major] Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Ovarian Neoplasms / metabolism. Sex Cord-Gonadal Stromal Tumors / metabolism

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  • (PMID = 17581419.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor
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51. Jarzembowski JA, Lieberman RW: Pediatric sex cord-stromal tumor with composite morphology: a case report. Pediatr Dev Pathol; 2005 Nov-Dec;8(6):680-4
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  • [Title] Pediatric sex cord-stromal tumor with composite morphology: a case report.
  • Histologically, the tumor exhibited several different morphologic appearances including adult granulosa cell tumor, juvenile granulosa cell tumor (with areas of marked atypia), and Sertoli cell tumor.
  • Immunohistochemically, the tumor was positive for calretinin, MIC-2 (CD99), S100 protein, PGP 9.5, and neuron-specific enolase.
  • Electron microscopy of the Sertoli cell tumor-like areas showed Charcot-Bottcher filaments, a distinguishing feature of Sertoli cells.
  • Together, these findings supported a diagnosis of mixed sex cord-stromal tumor including granulosa cell tumor of adult and juvenile types and intermediate- to high-grade Sertoli cell tumor, with large areas of markedly atypical sex cord-stromal tumor.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology
  • [MeSH-minor] Carcinoma, Small Cell / pathology. Child. Developmental Disabilities / complications. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Intellectual Disability / complications. Lymphoma / pathology. Microscopy, Electron, Transmission. Neuroectodermal Tumors, Primitive / pathology. Rhabdomyosarcoma / pathology. Sarcoma, Ewing / pathology

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  • (PMID = 16222477.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Kara C, Kutlu AO, Tosun MS, Apaydin S, Senel F: Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. Horm Res; 2005;63(5):252-6
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  • [Title] Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • Sertoli cell tumors in boys with PJS have been increasingly recognized as a cause of prepubertal gynecomastia.
  • We report on a 7.25-year-old boy with PJS, bilateral gynecomastia, Sertoli cell tumor and nephrocalcinosis, and present the outcome of 1-year treatment with the aromatase inhibitor testolactone.
  • The patient presented with bilateral breast and testis enlargement, and mucocutaneous pigmentation.
  • Testicular ultrasound revealed parenchymal multiple microcalcifications.
  • Histopathological examination was consistent with Sertoli cell tumors.
  • [MeSH-major] Aromatase Inhibitors / therapeutic use. Gynecomastia / complications. Peutz-Jeghers Syndrome / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testolactone / therapeutic use

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  • (PMID = 15947469.001).
  • [ISSN] 0301-0163
  • [Journal-full-title] Hormone research
  • [ISO-abbreviation] Horm. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 6J9BLA949Q / Testolactone
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53. Wang LF, Zhang SJ, Qi JP, Mei HL: [Large cell carcified Sertoli cell tumor]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):761-2
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  • [Title] [Large cell carcified Sertoli cell tumor].
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 16536333.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
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54. Zhang JW, Gou XM, Li Z, Peng TS: [Clinicopathologic features of large-cell calcifying Sertoli cell tumor of the testis]. Zhonghua Bing Li Xue Za Zhi; 2007 Apr;36(4):281-2
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  • [Title] [Clinicopathologic features of large-cell calcifying Sertoli cell tumor of the testis].
  • [MeSH-major] Calcinosis / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology. Testis / pathology

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  • (PMID = 17706128.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
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55. Ahtiainen P, Rulli SB, Shariatmadari R, Pelliniemi LJ, Toppari J, Poutanen M, Huhtaniemi IT: Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice. Oncogene; 2005 Nov 10;24(49):7301-9
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  • [Title] Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice.
  • We have previously demonstrated that male transgenic (TG) mice overexpressing human chorionic gonadotropin (hCG+) develop reproductive organ defects, but no tumors, in adult age.
  • Leydig cell (LC) adenomas were found in prepubertal mice, most prominently at the age of 10 days, but not in adult age.
  • Hence, the postnatal adenomas resemble functionally fetal LCs, and only these cells are susceptible to hCG-induced tumorigenesis.
  • [MeSH-major] Adenoma / etiology. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Gene Expression Regulation, Developmental. Glycoprotein Hormones, alpha Subunit / metabolism. Leydig Cells / metabolism
  • [MeSH-minor] 3-Hydroxysteroid Dehydrogenases / metabolism. Animals. Fetus. Gene Expression Regulation, Neoplastic. Humans. Intramolecular Oxidoreductases / metabolism. Lipocalins. Male. Mice. Mice, Transgenic. Phenotype. Testis / metabolism. Testis / pathology. Thrombospondins / metabolism. Up-Regulation

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  • (PMID = 16007123.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 0 / Glycoprotein Hormones, alpha Subunit; 0 / Lipocalins; 0 / Thrombospondins; 0 / thrombospondin 2; EC 1.1.- / 3-Hydroxysteroid Dehydrogenases; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.2 / prostaglandin R2 D-isomerase
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56. Chivukula M, Hunt J, Carter G, Kelley J, Patel M, Kanbour-Shakir A: Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis. Int J Gynecol Pathol; 2007 Jan;26(1):30-3
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  • Gynandroblastoma is a rare ovarian tumor that is composed of both Sertoli cells and granulosa cells.
  • A 49-year-old Gravida 0 woman with a 10-year prior diagnosis of ovarian-mixed stromal tissue tumor (well-differentiated Sertoli cell and granulosa cell tumor) and staging laparotomy, presented now with a retroperitoneal mass and an elevated inhibin level.
  • The histomorphological features of the recurrent tumor had both Sertoli cell and granulosa cell tumor.
  • The molecular analysis of both primary and recurrent tumor showed minor genetic instability in the 17q12.2 gene locus with no dedifferentiation or progression, which is consistent with a low-grade tumor.
  • All the previously mentioned immunostainings support the diagnosis.
  • [MeSH-major] Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology

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  • (PMID = 17197894.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Adayener C, Akyol I, Sen B, Ates F, Haholu A, Soydan H, Karagoz B: Sertoli cell tumor of the testis: a case with late metastasis. Int Urol Nephrol; 2008;40(4):1005-8
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  • [Title] Sertoli cell tumor of the testis: a case with late metastasis.
  • We report on a 20-year-old male who underwent a radical orchidectomy when he was 12 years old which revealed a Sertoli cell tumor in his right testis, and who presented with a 5 x 3 cm retroperitoneal metastatic mass 8 years after orchidectomy.
  • Current experience on Sertoli cell tumor of the testis (SCTT) is insufficient to prognosticate the clinical behavior of the primary tumor on the long term.
  • [MeSH-major] Retroperitoneal Neoplasms / secondary. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • [Cites] Am J Clin Pathol. 1994 Oct;102(4):397-401 [7524297.001]
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  • (PMID = 18500567.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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58. Gómez García I, Romero Molina M, López-García Moreno A, Buendía González E, Rubio Hidalgo E, Bolufer E, Sampietro Crespo A, Gómez Rodríguez A: Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. Arch Esp Urol; 2010 Jun;63(5):392-5
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  • [Title] Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature.
  • OBJECTIVE: We report two new cases of Sertoli cell testicular tumors, and a Cochrane and Medline search of cases published worldwide.
  • METHODS: We reviewed our series of testicular tumors, the stromal tumor incidence, clinical presentation, treatment and prognosis, and the experience reflected in the literature.
  • RESULTS: The prevalence of testicular tumors in our health area is of 0.09%, and 2.3% of them are Sertoli cell neoplasms.
  • This figure is slightly higher than the found in other series in which Sertoli tumors range from 0.4% to 1.5% of testicular malignancies in adults and reach 4% in children.
  • CONCLUSIONS: Sertoli cell tumor has an incidence not exceeding 4%.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 20587845.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
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59. Young RH: Testicular tumors--some new and a few perennial problems. Arch Pathol Lab Med; 2008 Apr;132(4):548-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular tumors--some new and a few perennial problems.
  • The histopathology of testicular tumors is presented, emphasizing new, unusual, or underemphasized aspects.
  • Within the category of seminoma of the usual type, the recent literature has drawn attention to the presence in occasional tumors of solid or hollow tubules or spaces of varying sizes and shape that may result in cribriform or microcystic patterns, causing potential confusion with other neoplasms, most notably Sertoli cell tumor or yolk sac tumor.
  • Although regions of typical neoplasia and awareness of this phenomenon usually will be diagnostic, immunohistochemistry may play a role in excluding Sertoli cell tumor or yolk sac tumor.
  • Although immunohistochemistry can play an undoubted helpful role in this and selected other areas of testicular tumor evaluation, careful evaluation of the gross and routine microscopic features will solve the vast majority of diagnostic problems.
  • Spermatocytic seminoma remains a crucial pitfall in diagnosis, and the pathologist must always be alert to the possible diagnosis when looking at a seminomatous neoplasm, particularly in an older patient, although about one third of these tumors occur in the usual seminoma age range.
  • The enigmatic and picturesque tumor, polyembryoma, which virtually never occurs in pure form but may be a confusing component of a variety of mixed germ cell tumors, is discussed and illustrated.
  • The phenomenon of burnt-out germ cell neoplasia is also briefly noted and an excellent recent contribution is referred to.
  • Within the sex cord-stromal family of neoplasms, recent contributions and elaborations of unusual morphologic features of Leydig cell tumors and Sertoli cell tumors are presented.
  • Within the Leydig cell family, cyst formation, adipose metaplasia, calcification or ossification, and spindle cell patterns may be particularly confusing, and in the Sertoli cell family, a great array of patterns caused by differing admixtures of tubular, solid, and stromal components occur.
  • The peculiar lesion, intratubular large cell hyalinizing Sertoli cell tumor, of young boys with Peutz-Jeghers syndrome, is briefly discussed.
  • Some of the problems in the family of hematopoietic neoplasms are reviewed, these processes posing diverse problems in differential diagnosis and their correct recognition having crucial therapeutic implications.
  • Although secondary tumors to the testis have not received the same attention in the literature as the similar phenomenon in the female gonad, remarkable examples of testicular spread of diverse neoplasms, usually carcinoma but rarely melanoma, are seen, and the pathologist should be alert to this possibility, particularly when examining an unusual morphology in an older patient.
  • Finally, a few comments are made on the common paratesticular neoplasm, the adenomatoid tumor, highlighting its varied patterns and recent description of some of the issues that may arise when they undergo total or subtotal infarction.
  • [MeSH-major] Pathology / education. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / pathology. Diagnosis, Differential. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Humans. Male. Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / pathology. Seminoma / diagnosis. Seminoma / pathology. Teratoma / diagnosis. Teratoma / pathology

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  • (PMID = 18384207.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 54
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60. Shin SL, Outwater EK: Benign large cell calcifying Sertoli cell tumor of the testis in a prepubescent patient. AJR Am J Roentgenol; 2007 Aug;189(2):W65-6
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  • [Title] Benign large cell calcifying Sertoli cell tumor of the testis in a prepubescent patient.
  • [MeSH-major] Sertoli Cell Tumor / radiography. Sertoli Cell Tumor / ultrasonography. Testicular Neoplasms / radiography. Testicular Neoplasms / ultrasonography
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17646440.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Sato K, Tachibana H, Morinaga S, Ueda Y, Katsuda S: Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S). Virchows Arch; 2007 Mar;450(3):361-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S).
  • [MeSH-major] Hemorrhage / pathology. Racemases and Epimerases / metabolism. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Male. Middle Aged. Orchiectomy. Testis / diagnostic imaging. Testis / pathology. Testis / surgery. Ultrasonography

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  • [Cites] Pathol Int. 2005 Jun;55(6):366-71 [15943795.001]
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  • (PMID = 17252229.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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67. Beck-Peccoz P, Persani L: TSH-induced hyperthyroidism caused by a pituitary tumor. Nat Clin Pract Endocrinol Metab; 2006 Sep;2(9):524-8; quiz following p528
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  • [Title] TSH-induced hyperthyroidism caused by a pituitary tumor.
  • On physical examination, he had a small goiter, normal skin, no Graves' ophthalmopathy, normal BMI, and reduced testis volume and pubic hair.
  • DIAGNOSIS: Hyperthyroidism caused by a mixed pituitary adenoma that secretes prolactin and TSH.
  • MANAGEMENT: Trans-sphenoidal resection of the pituitary tumor.
  • Hyperthyroidism and hypogonadism recurred after 5 years, therefore, treatment with lanreotide was initiated, and resulted in complete resolution of signs and symptoms of the disease.
  • [MeSH-major] Adenoma / complications. Hyperthyroidism / etiology. Pituitary Neoplasms / complications. Thyrotropin / metabolism
  • [MeSH-minor] Antithyroid Agents / therapeutic use. Diagnosis, Differential. Humans. Male. Middle Aged. Octreotide / therapeutic use. Peptides, Cyclic / therapeutic use. Somatostatin / analogs & derivatives. Somatostatin / therapeutic use

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  • (PMID = 16957766.001).
  • [ISSN] 1745-8366
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antithyroid Agents; 0 / Peptides, Cyclic; 118992-92-0 / lanreotide; 51110-01-1 / Somatostatin; 9002-71-5 / Thyrotropin; RWM8CCW8GP / Octreotide
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68. Ulbright TM: The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them. Adv Anat Pathol; 2008 Jan;15(1):18-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them.
  • Testicular tumors are both increasing in frequency and disproportionately occur in young men; furthermore, different forms of neoplasm require different treatments.
  • These considerations make the accurate diagnosis of testicular tumors especially important.
  • Many of the critical distinctions involve the differentiation of seminoma from one or more potential mimics because seminoma is not only the most common testicular neoplasm but it is also the only malignant testicular tumor that is commonly treated with radiation, which is ineffective in other malignancies of the testis.
  • For the most part, accurate diagnosis can be achieved by careful light microscopic evaluation, although appropriate immunostains can provide diagnostic assistance if doubt persists.
  • This article discusses a number of clinically important differential diagnoses in the testis that are common sources of misinterpretations.
  • These include: seminoma versus embryonal carcinoma, seminoma versus yolk sac tumor, seminoma versus Sertoli cell tumor, seminoma with syncytiotrophoblast cells versus choriocarcinoma, granulomatous seminoma versus granulomatous orchitis, intertubular seminoma versus orchitis, lymphoma versus seminoma or embryonal carcinoma, dermoid cyst versus teratoma, scar versus regressed germ cell tumor, and "anaplastic" spermatocytic seminoma versus usual seminoma or embryonal carcinoma.
  • [MeSH-major] Diagnostic Errors / prevention & control. Seminoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Embryonal / diagnosis. Carcinoma, Embryonal / pathology. Diagnosis, Differential. Endodermal Sinus Tumor / diagnosis. Endodermal Sinus Tumor / pathology. Humans. Male. Sertoli Cell Tumor / diagnosis. Sertoli Cell Tumor / pathology

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  • (PMID = 18156809.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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69. Zhao C, Vinh TN, McManus K, Dabbs D, Barner R, Vang R: Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. Am J Surg Pathol; 2009 Mar;33(3):354-66
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  • [Title] Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors.
  • Different immunohistochemical sex cord-stromal markers have been previously studied in various types of ovarian sex cord-stromal tumors; however, the sensitivity for sex cord-stromal lineage may vary between markers, and some markers may not be as sensitive in some types of sex cord-stromal tumors compared with other tumors in this spectrum of neoplasms.
  • The goals of this study were to determine which immunohistochemical markers are the most sensitive and immunohistochemically robust for sex cord-stromal lineage within a given type of ovarian sex cord-stromal tumor, and to establish whether there are substantial differences of expression of these markers between different types of sex cord-stromal tumors.
  • Immunohistochemical stains for markers which have known variable specificity for sex cord-stromal lineage [inhibin, calretinin, MART-1/melan-A, CD99, steroidogenic factor 1 (SF-1, adrenal 4-binding protein), and WT1], were performed in 127 cases of 5 different types of ovarian sex cord-stromal tumors: adult granulosa cell tumor (n=32), Sertoli cell tumor (n=27), Sertoli-Leydig cell tumor (n=18), steroid cell tumor (n=25), and fibroma/fibrothecoma (n=25).
  • All cases in each type of sex cord-stromal tumor expressed SF-1.
  • Inhibin and calretinin were expressed in all groups of tumors but with a lesser frequency (56% to 100% and 36% to 100% of cases, respectively).
  • All types of tumors except steroid cell tumor expressed WT1.
  • Fibroma/fibrothecoma was the only type of tumor that did not express CD99.
  • The only tumor groups that showed expression of MART-1 were Sertoli-Leydig cell tumor (restricted to the Leydig cell component) and steroid cell tumor (94% and 96% of cases, respectively).
  • The type of sex cord-stromal tumor that was least frequently positive for several of the different markers studied was fibroma/fibrothecoma.
  • Among all tumor groups combined, inhibin and WT1 were the 2 markers showing the most diffuse expression.
  • Likewise, the single marker showing the most optimal combination of diffuse and strong staining (immunohistochemical composite score: possible range, 1 to 12) varied between tumors: adult granulosa cell tumor-inhibin (score 10.0); Sertoli cell tumor-WT1 (score 10.8); Sertoli-Leydig cell tumor (Sertoli cell component)-WT1 (score 10.4); steroid cell tumor-inhibin (score 11.2); and fibroma/fibrothecoma-WT1 (score 8.9).
  • Although each of the different types of sex cord-stromal tumors has a slightly unique immunoprofile in terms of frequency and extent of expression, these differences are relatively minor for most types of tumors with certain exceptions (eg, WT1 is not diagnostically useful in steroid cell tumor; CD99 is not diagnostically useful in fibroma/fibrothecoma; the only sex cord-stromal tumor for which MART-1 is diagnostically useful is steroid cell tumor; inhibin and calretinin are less diagnostically useful in fibroma/fibrothecoma than in the other types of tumors, but expression in fibrothecoma was higher than in fibroma).
  • SF-1 is the most sensitive sex cord-stromal marker among the most common types of sex cord-stromal tumors.
  • Given the findings relating to sensitivity and extent of expression in this study, and known specificity in the literature, the most informative sex cord-stromal markers to be used for the distinction from nonsex cord-stromal tumors are inhibin, calretinin, SF-1, and WT1 (the exact number of markers to be used should be based on the degree of difficulty of the case and level of experience of the pathologist); however, the utility of immunohistochemistry for the diagnosis of fibroma/fibrothecoma is somewhat limited.
  • [MeSH-major] Biomarkers, Tumor / analysis. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / metabolism. Sex Cord-Gonadal Stromal Tumors / pathology

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  • (PMID = 19033865.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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70. Vegter AR, Kooistra HS, van Sluijs FJ, van Bruggen LW, Ijzer J, Zijlstra C, Okkens AC: Persistent Mullerian duct syndrome in a Miniature Schnauzer dog with signs of feminization and a Sertoli cell tumour. Reprod Domest Anim; 2010 Jun;45(3):447-52
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  • [Title] Persistent Mullerian duct syndrome in a Miniature Schnauzer dog with signs of feminization and a Sertoli cell tumour.
  • Abdominal ultrasonography revealed an enlarged right testis and a large, fluid-filled cavity that appeared to arise from the prostate.
  • Gonadohysterectomy was performed and both the surgical and the histological findings confirmed the presence of a uterus in this male animal, resulting in a diagnosis of persistent Mullerian duct syndrome (PMDS).
  • The enlarged intra-abdominal testis contained a Sertoli cell tumour.
  • [MeSH-major] Dog Diseases / diagnosis. Feminization / veterinary. Mullerian Ducts. Sertoli Cell Tumor / veterinary
  • [MeSH-minor] Animals. Cryptorchidism / pathology. Cryptorchidism / veterinary. Disorders of Sex Development / diagnosis. Disorders of Sex Development / surgery. Disorders of Sex Development / veterinary. Dogs. Female. Karyotyping / veterinary. Male. Testis / pathology. Tomography, X-Ray Computed. Ultrasonography / veterinary. Uterus / pathology. Uterus / surgery

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  • (PMID = 18954385.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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71. Miller MA, Hartnett SE, Ramos-Vara JA: Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. Vet Pathol; 2007 May;44(3):394-7
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  • [Title] Interstitial cell tumor and Sertoli cell tumor in the testis of a cat.
  • Testicular tumors are rarely reported in cats.
  • We describe a case of interstitial cell tumor and Sertoli cell tumor in a cat that developed aggressive behavior and inappropriate urination 7 years after it was obtained from a shelter as an allegedly castrated 2 year old.
  • Testes were not palpable, but the left testis was found in the scrotum by surgical exploration and was mostly replaced by the 2 tumors.
  • The interstitial cell tumor, but not the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with steroid production.
  • Behavior improved after excision of the testis and penile papillae began to regress, but the cat was euthanatized 3 1/2 months after castration at the owner's request.
  • Neither tumor had metastasized.
  • The right testis was never found and was presumed to have been removed during the reported castration procedure.
  • [MeSH-major] Cat Diseases / pathology. Leydig Cell Tumor / veterinary. Sertoli Cell Tumor / veterinary

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  • (PMID = 17491086.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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72. van der Putte SC, Toonstra J, Sie-Go DM: Müllerian serous cystadenoma of the scrotum following orchiopexy. Adv Urol; 2009;:610453
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  • Histological and immunohistological features were not consistent neither with median raphe cysts or cutaneous adenomas nor with the intrascrotal adenomas of the rete testis, epididymis, nor with (malignant) mesotheliomas.
  • However, the lesion did compare well with serous (papillary) cystadenomas of the testis or paratestis.
  • These adenomas are thought to originate in remnants of the Müllerian system or of peritoneal lining altered by Müllerian metaplasia.
  • This implies that the scrotal adenoma may have developed from an implant of such elements during orchiopexy 14 years ago.

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  • (PMID = 19343186.001).
  • [ISSN] 1687-6369
  • [Journal-full-title] Advances in urology
  • [ISO-abbreviation] Adv Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2662405
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73. Ciccarelli A, Guerra E, De Rosa M, Milone F, Zarrilli S, Lombardi G, Colao A: PRL secreting adenomas in male patients. Pituitary; 2005;8(1):39-42
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  • [Title] PRL secreting adenomas in male patients.
  • Prolactinomas are the most frequent pituitary tumors and their frequency varies with age and sex, occurring most frequently in females between 20-50 yr-old.
  • Prolactin (PRL) plays a role in the process of spermatogenesis, and normal serum PRL levels are required for normal testicular function.
  • Cabergoline treatments is able to induce normalization of PRL levels and a reduction of tumor mass in the majority of patients and consequently restoring the normal semen quality and ameliorating the quality of life of men with pituitary PRL-secreting adenoma.
  • [MeSH-minor] Age Factors. Dopamine Agonists / therapeutic use. Ergolines / therapeutic use. Humans. Libido. Male. Prevalence. Prostatic Hyperplasia / complications. Prostatic Hyperplasia / physiopathology. Semen / physiology. Sex Factors. Spermatogenesis. Testis / physiology

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  • (PMID = 16411067.001).
  • [ISSN] 1386-341X
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dopamine Agonists; 0 / Ergolines; 9002-62-4 / Prolactin; LL60K9J05T / cabergoline
  • [Number-of-references] 20
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74. Gopinath D, Draffan D, Philbey AW, Bell R: Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour. J Small Anim Pract; 2009 Apr;50(4):198-200
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  • [Title] Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour.
  • A seven-year-old, 31 kg male neutered Labrador was investigated for signs of feminisation syndrome and prostatic disease four years after castration and removal of a testicular sertoli cell tumour (SCT).
  • [MeSH-major] Dog Diseases / diagnosis. Estradiol / analysis. Lung Neoplasms / veterinary. Sertoli Cell Tumor / veterinary. Testicular Neoplasms / veterinary

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  • (PMID = 19037884.001).
  • [ISSN] 0022-4510
  • [Journal-full-title] The Journal of small animal practice
  • [ISO-abbreviation] J Small Anim Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 4TI98Z838E / Estradiol
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75. Al-Agha OM, Tahmasebi FC, Nicastri AD: A 67-year-old woman with abdominal distention, vaginal bleeding, and elevated CA 125 level. Pure Sertoli cell tumor of the ovary with differentiation varying from well-differentiated tubules, to intermediate foci, to sarcomatoid spindle cell areas. Arch Pathol Lab Med; 2006 May;130(5):e70-3
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  • [Title] A 67-year-old woman with abdominal distention, vaginal bleeding, and elevated CA 125 level. Pure Sertoli cell tumor of the ovary with differentiation varying from well-differentiated tubules, to intermediate foci, to sarcomatoid spindle cell areas.
  • [MeSH-major] CA-125 Antigen / blood. Gastric Dilatation / diagnosis. Ovarian Neoplasms / pathology. Sarcoma / pathology. Sertoli Cell Tumor / pathology. Uterine Hemorrhage / diagnosis
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic. Female. Humans. Treatment Outcome

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  • (PMID = 16683900.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-125 Antigen
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76. D'Souza L, Burgis JT, Bacon JL, Camps JI: A pure Sertoli cell tumor of the ovary in a 10-year-old female. J Pediatr Adolesc Gynecol; 2007 Aug;20(4):257-9
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  • [Title] A pure Sertoli cell tumor of the ovary in a 10-year-old female.
  • STUDY OBJECTIVE: To document an unusual presentation of a pure Sertoli Cell tumor.
  • Surgical exploration revealed a metastatic pure Sertoli Cell tumor, which was treated with resection and chemotherapy.
  • CONCLUSION: Sertoli cell tumors are rare occurrences and should be considered in the differential diagnosis for a prepubescent girl with an abdominal mass.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sertoli Cell Tumor / pathology

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  • (PMID = 17673140.001).
  • [ISSN] 1083-3188
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Zhao C, Bratthauer GL, Barner R, Vang R: Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases. Am J Surg Pathol; 2007 Feb;31(2):255-66
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  • [Title] Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases.
  • The main neoplasms in the differential diagnosis for primary ovarian tumors with a tubule-rich pattern are pure Sertoli cell tumor, endometrioid tumors (including borderline tumor, well-differentiated carcinoma, and the sertoliform variant of endometrioid carcinoma), and carcinoid tumor.
  • Because traditional immunohistochemical markers [pan-cytokeratin (pan-CK), low molecular weight cytokeratin (CK8/18), epithelial membrane antigen (EMA), inhibin, calretinin, CD99, chromogranin, and synaptophysin] can occasionally have diagnostic limitations, the goal of this study was to determine whether or not any alternative markers [cytokeratin 7 (CK7), estrogen receptor (ER), progesterone receptor (PR), CD10, and CD56] have better diagnostic utility when compared with traditional markers for this differential diagnosis.
  • Immunohistochemical stains for alternative, as well as traditional, markers were performed on the following primary ovarian tumors: pure Sertoli cell tumor (n = 40), endometrioid borderline tumor (n = 38), sertoliform endometrioid carcinoma (n = 13), well-differentiated endometrioid carcinoma (n = 27), and carcinoid tumor (n = 42).
  • Cytokeratin 7 (CK7) was positive in 97% of endometrioid tumors, 13% of Sertoli cell tumors, and 24% of carcinoid tumors.
  • The differences in the mean ICSs for endometrioid tumors versus Sertoli cell tumor or carcinoid tumor were statistically significant (P values ranging from <0.001 to 0.018).
  • ER and PR were positive in 87% and 86% of endometrioid tumors, 8% and 13% of Sertoli cell tumors, and 2% each of carcinoid tumors, respectively.
  • The differences in the mean ICSs for endometrioid tumors versus Sertoli cell tumor were statistically significant (P values ranging from <0.001 to 0.012).
  • CD10 showed overlapping patterns of expression in all categories of tumors.
  • CD56 showed overlapping patterns of expression in all categories of tumors.
  • When traditional immunohistochemical markers are problematic for the differential diagnosis of ovarian Sertoli cell tumor versus endometrioid tumors versus carcinoid tumor, adding CK7, ER, and/or PR to a panel of markers can be helpful.
  • Endometrioid tumors more frequently express CK7, ER, and PR and show a greater extent of immunostaining in contrast to Sertoli cell tumor and carcinoid tumor.
  • Inhibin is the most discriminatory sex cord marker, and CD10 is not helpful in the differential diagnosis.
  • Chromogranin and synaptophysin are excellent discriminatory markers for carcinoid tumor, and CD56 is neither sufficiently sensitive nor specific enough for this differential diagnosis to warrant its use in routine practice.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoid Tumor / diagnosis. Carcinoma, Endometrioid / diagnosis. Neoplasm Proteins / analysis. Ovarian Neoplasms / diagnosis. Sertoli Cell Tumor / diagnosis
  • [MeSH-minor] Cell Count. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Neurosecretory Systems / chemistry


78. Boyer A, Paquet M, Laguë MN, Hermo L, Boerboom D: Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis; 2009 May;30(5):869-78
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  • [Title] Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis.
  • Synergistic effects of dysregulation of the WNT/CTNNB1 and phosphatidylinositol 3-kinase (PI3K)/AKT pathways are thought to be important for the development and progression of many forms of cancer, including the granulosa cell tumor of the ovary.
  • Sustained WNT/CTNNB1 signaling in Sertoli cells causes testicular degeneration and the formation of foci of poorly differentiated stromal cells in the seminiferous tubules in mice.
  • To test if concomitant dysregulation of the WNT/CTNNB1 and PI3K/AKT pathways could synergize to cause testicular cancer, Pten(tm1Hwu/tm1Hwu);Ctnnb1(tm1Mmt/+);Amhr2(tm3(cre)Bhr/+) mice that express a dominant, stable CTNNB1 mutant and lack the expression of phosphatase and tensin homolog (PTEN) in their Sertoli cells were generated.
  • These mice developed aggressive testicular cancer with 100% penetrance by 5 weeks of age, and 44% of animals developed pulmonary metastases by 4 months, whereas Pten(tm1Hwu/tm1Hwu);Amhr2(tm3(cre)Bhr/+) controls were phenotypically normal.
  • Surprisingly, the tumors could not be classified as Sertoli cell tumors, but rather bore histologic and ultrastructural characteristics of granulosa cell tumors of the testis (GCTT).
  • Pten(tm1Hwu/tm1Hwu);Ctnnb1(tm1Mmt/+);Amhr2(tm3(cre)Bhr/+) testicular tumors did not express CYP17, CYP19, germ cell nuclear antigen, estrogen receptor 1 or progesterone receptor, but expressed the early granulosa cell markers WNT4 and FOXL2, confirming the diagnosis of GCTT.
  • Immunohistochemical analyses of Pten(tm1Hwu/tm1Hwu);Ctnnb1(tm1Mmt/+);Amhr2(tm3(cre)Bhr/+) GCTT demonstrated a tumor marker profile similar to that reported in human GCTT.


79. Veeramachaneni DN, Amann RP, Jacobson JP: Testis and antler dysgenesis in sitka black-tailed deer on Kodiak Island, Alaska: Sequela of environmental endocrine disruption? Environ Health Perspect; 2006 Apr;114 Suppl 1:51-9
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  • [Title] Testis and antler dysgenesis in sitka black-tailed deer on Kodiak Island, Alaska: Sequela of environmental endocrine disruption?
  • We sought to better understand the problem and investigated 171 male deer for phenotypic aberrations and 12 for detailed testicular histopathology.
  • All 11 abdominal testes examined had no spermatogenesis but contained abnormalities including carcinoma in situ-like cells, possible precursors of seminoma; Sertoli cell, Leydig cell, and stromal cell tumors; carcinoma and adenoma of rete testis; and microlithiasis or calcifications.
  • However, based on lesions observed, we hypothesize that it is more likely that this testis-antler dysgenesis resulted from continuing exposure of pregnant females to an estrogenic environmental agent(s), thereby transforming testicular cells, affecting development of primordial antler pedicles, and blocking transabdominal descent of fetal testes.
  • [MeSH-major] Antlers / abnormalities. Deer. Endocrine Disruptors / toxicity. Gonadal Dysgenesis / chemically induced. Testis / abnormalities
  • [MeSH-minor] Alaska. Animals. Cryptorchidism / chemically induced. Cryptorchidism / complications. Cryptorchidism / genetics. Environmental Exposure / adverse effects. Estrogens / toxicity. Hyperplasia / chemically induced. Leydig Cells / cytology. Leydig Cells / drug effects. Male. Testicular Neoplasms / chemically induced. Testicular Neoplasms / etiology

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  • (PMID = 16818246.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Endocrine Disruptors; 0 / Estrogens
  • [Other-IDs] NLM/ PMC1874179
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80. Jabbour SA, Davidovici BB, Wolf R: Rare syndromes. Clin Dermatol; 2006 Jul-Aug;24(4):299-316
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  • Some of these endocrine disorders include glucagonoma, neurofibromatosis type 1, McCune-Albright syndrome, multiple endocrine neoplasia, the Carney complex, carcinoid tumors, and mastocytosis.
  • Other presenting features include freckling, peripheral neurofibromas, Lisch nodules, bone abnormalities, tumors, neurologic abnormalities and hypertension.
  • Multiple endocrine neoplasia type 1 is an autosomal dominant predisposition to tumors of the parathyroid glands (four-gland hyperplasia), anterior pituitary, and pancreatic islet cells; hence, the mnemonic device of the "3 Ps"; multiple cutaneous lesions (angiofibromas and collagenomas) are frequent in patients with multiple endocrine neoplasia type 1.
  • Carney complex may be viewed as a form of multiple endocrine neoplasia because affected patients often have tumors of two or more endocrine glands, including primary pigmented nodular adrenocortical disease (some with Cushing's syndrome), pituitary adenoma, testicular neoplasms, thyroid adenoma or carcinoma, and ovarian cysts.
  • Additional unusual manifestations include psammomatous melanotic schwannoma, breast ductal adenoma, and a rare bone tumor, osteochondromyxoma.
  • Carcinoid syndrome is the term applied to a constellation of symptoms mediated by various humoral factors elaborated by some carcinoid tumors; the major manifestations are diarrhea, flushing, bronchospasm, and cardiac valvular lesions.
  • Mast cell diseases include all disorders of mast cell proliferation.
  • These diseases can be limited to the skin, referred to as "cutaneous mastocytosis," or involve extracutaneous tissues, called "systemic mastocytosis."
  • [MeSH-major] Endocrine System Diseases / genetics. Endocrine System Diseases / pathology. Mastocytosis, Cutaneous / pathology. Multiple Endocrine Neoplasia / genetics. Multiple Endocrine Neoplasia / pathology

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  • (PMID = 16828412.001).
  • [ISSN] 0738-081X
  • [Journal-full-title] Clinics in dermatology
  • [ISO-abbreviation] Clin. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 155
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81. Haddad O, Leroy X, Lemaitre L, Biserte J, Rigot JM: [Infertility and testicular tumour based on a series of 25 patients]. Prog Urol; 2005 Dec;15(6):1096-100
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  • [Title] [Infertility and testicular tumour based on a series of 25 patients].
  • [Transliterated title] Infertilité et tumeur du testicule: a propos de 25 patients.
  • OBJECTIVES: To evaluate the frequency of testicular tumours in infertile men and to specify their clinical, ultrasound and histological characteristics.
  • RESULTS: Twenty-six testicular tumours were operated in 25 patients, i.e.
  • Histological examination demonstrated 15 Leydig cell tumours (58%), 8 seminomas (30%), mature teratoma,1 Sertoli cell tumour, and 1 burnt-out tumour.
  • Tumour markers were normal in 24 of the 25 patients (96%).
  • CONCLUSION: The incidence of testicular tumours in infertile men is much higher than in the general population.
  • [MeSH-major] Infertility, Male / etiology. Testicular Neoplasms / complications

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  • (PMID = 16429659.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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82. Al-Maghrabi JA: Large cell calcifying Sertoli cell tumor of the testis. Ann Saudi Med; 2005 Sep-Oct;25(5):436-7
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  • [Title] Large cell calcifying Sertoli cell tumor of the testis.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology. Testis / pathology

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  • (PMID = 16270775.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone
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83. Luby CD, Middleton JR, Youngquist RS, Kim DY, Evans AT: Theriogenology question of the month. Sertoli cell tumor. J Am Vet Med Assoc; 2007 Nov 15;231(10):1503-5
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  • [Title] Theriogenology question of the month. Sertoli cell tumor.
  • [MeSH-major] Cattle Diseases / diagnosis. Scrotum / pathology. Sertoli Cell Tumor / veterinary

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  • (PMID = 18020990.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Teixeira RL, Rossini A, Paim NP: [Testicular tumors in childhood]. Rev Col Bras Cir; 2009 Feb;36(1):85-9
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  • [Title] [Testicular tumors in childhood].
  • Testicular and paratesticular prepuberal tumors are rare.
  • They represent around 1% of the total of tumors of infancy.
  • They subdivide in 2 groups: germ cells tumors and non germ cells tumors, being able to occur in all the ages, and about 75% are malignant, and about 19% of these they present metastasis.
  • The tumors of germ cells tumors represent 60 75% of the tumors testiculars in infancy, having as main example the yolk sac tumor (65% of the neoplasms), followed for teratomas (14%); although some works to exist where teratoma, if presents as most common .The non germ cells tumors include the Leydig cell tumor and Sertoli cell tumor.
  • The Leydig cell tumor, are most frequent between the non germ cells tumors testicular.
  • This review article on epidemiology, diagnosis and treatment of to testicular and to paratesticular tumors in child.
  • [MeSH-major] Testicular Neoplasms
  • [MeSH-minor] Child. Endodermal Sinus Tumor / pathology. Humans. Male. Teratoma / pathology

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  • (PMID = 20076873.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 35
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85. Sasaki M, Ota S: [A case of sertoli cell tumor with arteriovenous malformation]. Hinyokika Kiyo; 2010 Jan;56(1):55-8
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  • [Title] [A case of sertoli cell tumor with arteriovenous malformation].
  • Ultrasonography and computed tomography (CT) demonstrated hematoma and testicular tumor with abundant blood flow in the right testis.
  • Radical orchiectomy was performed under a diagnosis of right testicular tumor.
  • Histological analysis of the lesion indicated a Sertoli cell tumor.
  • [MeSH-major] Arteriovenous Malformations / complications. Sertoli Cell Tumor / complications. Testicular Neoplasms / complications. Testis / blood supply

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  • (PMID = 20104012.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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86. Saraco N, Berensztein E, Sciara M, de Davila MT, Ciaccio M, Ferrari P, Belgorosky A, Rivarola MA: High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis. Pediatr Dev Pathol; 2006 May-Jun;9(3):181-9
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  • [Title] High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis.
  • Large cell calcifying Sertoli cell tumors (LCCSCT) are associated with Carney complex and Peutz-Jeghers syndrome.
  • The mechanisms linking these 2 genetic defects to the genesis of this tumor are obscure.
  • Studies of CYP19 (aromatase) and transforming growth factor (TGF)-beta1 messenger RNA (mRNA) abundance, estrogen receptor (ER), TGFbeta1, and TGFbeta type II receptor (R) immunochemistry were carried out in the testis of a patient with this tumor to gain information on possible mechanisms of cell tumor development.
  • Testicular tissue of a prepubertal patient, collected at gonadectomy, was separated into 2 macroscopically distinct fractions: tumoral nodules (Tu) and extratumoral, normal-looking testicular tissue (ExTu).
  • The patient was a 9.5-year-old boy with a 5-year history of bilateral gynecomastia (Tanner stage 4), no pubic hair, incipient genital development, and bilateral testicular nodules.
  • Cell proliferation was estimated by Ki-67 antigen immunochemistry and apoptosis using a modified TUNEL assay.
  • Positive staining of Sertoli cells in Tu was higher than in ExTu.
  • TGFbeta type II R immunostaining was detected in most Sertoli and interstitial cells, but intensity in ExTu was lower than in Tu.
  • No significant difference was detected in the proliferation index, but in Tu, the percentage of Sertoli cells in apoptosis (1.4%) was significantly lower (P<0.01) than in ExTu (14.0%).
  • The congenital gene defects of Carney complex or of Peutz-Jeghers syndrome might trigger a cascade of intracellular events that leads to overexpression of aromatase in Sertoli cells, favoring the development of a LCCSCT.
  • At some point in the evolution of the disease, a mutational event might induce a higher expression of the ER.
  • In this environment, TGFbeta1 might switch from tumor suppressor to oncogenic factor and, along with estrogen-ER complexes, might favor tumor progression by inhibiting apoptosis.
  • [MeSH-major] Aromatase / metabolism. Calcinosis. Receptors, Estrogen / metabolism. Sertoli Cell Tumor. Testicular Neoplasms. Transforming Growth Factor beta / metabolism

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  • (PMID = 16944977.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptors, Estrogen; 0 / Transforming Growth Factor beta; EC 1.14.14.1 / Aromatase
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87. Ulbright TM, Young RH: Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features. Am J Surg Pathol; 2008 Nov;32(11):1683-93
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  • [Title] Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features.
  • Metastatic carcinomas to the testis may simulate primary testicular neoplasms, even in patients with known extratesticular primaries, but information on this topic is limited.
  • The tumors occurred in men 29 to 90 years old, with the prostate the most common primary site (N=11), followed by the renal parenchyma (N=4), colon (N=4), urinary tract (N=3), lung (N=2), esophagus (N=1), and, most probably, small intestine (carcinoid, N=1).
  • Noteworthy findings included: the frequent absence of a known primary tumor (62%), the rarity of bilateral involvement (8%), the occasional lack of a distinct mass on gross examination (15%), the infrequency of multinodularity either grossly (8%) or microscopically (35%), the prominence of intertubular growth (42%), conspicuous intrarete or intratubular growth in some cases (especially prostate carcinoma) (19%), prominent cytoplasmic vacuoles in occasional cases (15%), and the frequent presence of lymphatic involvement (69%).
  • Four tumors (3 prostate, 1 renal) with prominent intrarete and/or intratubular growth had submitting diagnoses of either a primary rete neoplasm or seminoma.
  • Four tumors (2 prostate, 1 renal, and 1 bladder) with prominently vacuolated pale cells simulated Sertoli cell tumor.
  • We conclude that, if autopsy cases and incidental tumors in therapeutic orchiectomy specimens are excluded, metastatic carcinomas to the testis are usually solitary, unilateral tumors that may simulate primary neoplasms, including rete adenocarcinoma and Sertoli cell tumor.
  • Despite the rarity of documented cases in the literature, the bladder and renal pelvis should not be overlooked as possible sources for testicular metastasis.
  • The pathologist must have a high index of suspicion for the possibility of a metastatic carcinoma to the testis for any testicular tumor where the routine light microscopic or immunohistochemical findings are unusual for a primary neoplasm.
  • [MeSH-major] Carcinoma / secondary. Testicular Neoplasms / secondary

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  • (PMID = 18769334.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Zhao C, Bratthauer GL, Barner R, Vang R: Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. Am J Surg Pathol; 2007 Sep;31(9):1378-86
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  • [Title] Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.
  • WT1, the Wilms tumor gene product, can be expressed in various tumors from different anatomic sites, including some types of ovarian tumors.
  • Regarding the latter, most studies have focused on surface epithelial-stromal tumors in which serous carcinomas are usually positive and endometrioid carcinomas are negative.
  • Very few studies have specifically investigated this marker in ovarian sex cord-stromal tumors; however, limited data in the literature suggest that WT1 may be frequently expressed in sex cord-stromal tumors.
  • As pure Sertoli cell tumor can be in the histologic differential diagnosis of endometrioid tumors (particularly borderline tumor and carcinoma) and carcinoid, immunostaining for WT1 might be of diagnostic value.
  • Immunohistochemical staining for WT1 was performed in 108 ovarian tumors: pure Sertoli cell tumor (n=26), endometrioid borderline tumor (n=25), classic well-differentiated endometrioid carcinoma (n=23), sertoliform endometrioid carcinoma (n=12), and carcinoid (n=22).
  • Additionally, inhibin and calretinin immunostaining were performed in all cases of Sertoli cell tumor for purposes of comparing expression with WT1.
  • Nuclear expression of WT1 was present in 96% of Sertoli cell tumors, 16% of endometrioid borderline tumors, 13% of classic well-differentiated endometrioid carcinomas, 25% of sertoliform endometrioid carcinomas, and 0% of carcinoids.
  • In Sertoli cell tumors, expression was diffuse (>50% of positive cells) in all positive cases.
  • When positive in the non-Sertoli cell tumors, the extent of expression tended to be focal to patchy (50% or less positive cells).
  • In Sertoli cell tumors, inhibin and calretinin were expressed in 96% and 54% of cases, respectively.
  • Coordinate patterns for the extent of expression of WT1, inhibin, and calretinin in pure Sertoli cell tumor showed that all 3 markers were positive in 54% of cases; however, 42% were positive for WT1 and inhibin but negative for calretinin.
  • We conclude that ovarian Sertoli cell tumor should be added to the growing list of WT1-positive tumors.
  • This marker is useful for the distinction of Sertoli cell tumor from endometrioid tumors and carcinoid.
  • The diagnostic utility of WT1 in Sertoli cell tumor is similar to inhibin but better than that of calretinin.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoid Tumor / diagnosis. Carcinoma, Endometrioid / diagnosis. Immunohistochemistry. Ovarian Neoplasms / diagnosis. Sertoli Cell Tumor / diagnosis. WT1 Proteins / analysis
  • [MeSH-minor] Calbindin 2. Cell Differentiation. Diagnosis, Differential. Female. Humans. Inhibins / analysis. Predictive Value of Tests. Reproducibility of Results. S100 Calcium Binding Protein G / analysis

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  • (PMID = 17721194.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / WT1 Proteins; 57285-09-3 / Inhibins
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89. Chierigo P, Puccetti O, Visonà A, Bassan F, Rahmati M, Lazzarotto M, Franzolin N: [High alpha-fetoprotein persistence after orchiectomy. On a case of uncommon etiology]. Urologia; 2010 Oct-Dec;77 Suppl 17:27-31
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  • [Transliterated title] Persistenza di alfa-fetoproteina elevata dopo orchiectomia. Su di un caso ad etiologia inusuale.
  • BACKGROUND: The following report describes a case of inherited elevation of alpha-fetoprotein (AFP) in a young male suspected for testicular cancer.
  • From this age on, serum AFP can rise above normal in some diseases, e.g. liver disorders, and in some kind of tumors.
  • METHODS: An elevated serum AFP (about 20 µg/mL) was found in a 27-year-old white man with an unremarkable medical history, who was concerned to have left testicular cancer.
  • By our examination, his left testis was markedly reduced in size.
  • Surgical inguinal exploration with testis and spermatic cord excision was carried out.
  • Careful evaluation for occult cancer showed no abnormality.
  • Histology showed necrotic tissue and could not make a reliable diagnosis.
  • RESULTS: AFP was found to be elevated in another four out of six relatives within three generations, unrelated to any disease.
  • The existence of this clinically benign condition needs to be considered in both children and adults with unexplained and persistent elevation of AFP, e.g. those diagnosed or suspected for germ cell tumor.
  • [MeSH-major] Metabolism, Inborn Errors / diagnosis. Orchiectomy. alpha-Fetoproteins / analysis
  • [MeSH-minor] Adenoma / complications. Adrenal Gland Neoplasms / complications. Adult. Diagnosis, Differential. Genes, Dominant. Humans. Ischemia / surgery. Male. Neoplasms, Germ Cell and Embryonal / diagnosis. Postoperative Period. Testicular Neoplasms / diagnosis. Testis / blood supply. Testis / pathology. Unnecessary Procedures

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  • (PMID = 21308671.001).
  • [ISSN] 1724-6075
  • [Journal-full-title] Urologia
  • [ISO-abbreviation] Urologia
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / alpha-Fetoproteins
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90. Doxsee AL, Yager JA, Best SJ, Foster RA: Extratesticular interstitial and Sertoli cell tumors in previously neutered dogs and cats: a report of 17 cases. Can Vet J; 2006 Aug;47(8):763-6
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  • [Title] Extratesticular interstitial and Sertoli cell tumors in previously neutered dogs and cats: a report of 17 cases.
  • Primary neoplasms derived from testicular tissue and in an extratesticular location are extremely rare.
  • Clinical and surgical information was collected and verified from 15 different submitting practices for 12 dogs and 5 cats that spontaneously developed neoplasms of testicular origin after castration.
  • Eleven dogs had Sertoli cell tumors in an extratesticular location.
  • One dog and all 5 cats had an extratesticular interstitial cell tumor.
  • Six animals (1 dog, 5 cats) had developed secondary sexual characteristics that reversed after removal of the tumor.
  • No animals died of neoplasia-related disease and no metastases were identified.
  • Several possibilities, including the presence of embryological ectopic tissue or the presence of testicular tissue transplanted during castration, are considered as causal.
  • [MeSH-major] Cat Diseases / pathology. Dog Diseases / pathology. Leydig Cell Tumor / veterinary. Sertoli Cell Tumor / veterinary. Testicular Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Dogs. Immunohistochemistry / veterinary. Male. Neoplasm Metastasis. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / veterinary. Orchiectomy / veterinary. Retrospective Studies. Testis / pathology. Treatment Outcome

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  • (PMID = 16933553.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal = La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC1524845
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91. Wang M, Futamura M, Wang Y, You M: Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus. Oncogene; 2005 Mar 10;24(11):1958-63
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  • [Title] Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus.
  • Pas1c1 transcripts were also detected in heart, testis, or brain but not in liver, spleen, or kidney.
  • These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation.
  • [MeSH-major] Adenoma / genetics. Genetic Predisposition to Disease. Lung Neoplasms / genetics. Tumor Suppressor Proteins / genetics


92. Vallangeon BD, Eble JN, Ulbright TM: Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses. Am J Surg Pathol; 2010 Dec;34(12):1874-80
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  • [Title] Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses.
  • Sertoli cell nodules are almost always incidental microscopic lesions found in both cryptorchid and normally descended testes.
  • Sertoli cell nodules, when present as masses or ultrasonographic lesions, may create diagnostic confusion.
  • Herein, we report 6 cases of macroscopic Sertoli cell nodules that were received in consultation.
  • The referral diagnoses included Sertoli cell tumor (2 cases), sex cord tumor with annular tubules (1 case), and gonadoblastoma (1 case).
  • The patients were 19 to 36 years old: 3 patients presented with palpable testicular masses and 3 with lesions that were worrisome for neoplasms in ultrasonographic examinations conducted for pain (2 cases) or infertility (1 case).
  • The Sertoli cell nodules ranged from 6 to 10 mm in diameter and on microscopic examination consisted of circumscribed proliferations of immature Sertoli cells, globules and trabeculae of basement membrane, and spermatogonia in varying proportions.
  • Immunostains for α-inhibin highlighted the Sertoli cells (5 of 5 cases), with the germ cells appearing in negative relief.
  • An antibody for testis-specific protein, Y-encoded (TSPY), stained the spermatogonia (2 of 2 cases), whereas OCT 3/4 was negative in all the cases (5 of 5 cases).
  • We conclude that Sertoli cell nodules may present clinically as mass lesions, and that it is important to distinguish them from true neoplasms to avoid unnecessary procedures.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Gonadoblastoma / diagnosis. Humans. Inhibins / metabolism. Male. Sex Cord-Gonadal Stromal Tumors / diagnosis. Young Adult

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  • (PMID = 21107095.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / inhibin-alpha subunit; 57285-09-3 / Inhibins
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93. Zhao C, Barner R, Vinh TN, McManus K, Dabbs D, Vang R: SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor. Int J Gynecol Pathol; 2008 Oct;27(4):507-14
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  • [Title] SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor.
  • Immunohistochemistry can be an important part of the diagnosis of Sertoli cell tumor of the ovary, including distinction from non-sex cord-stromal tumors such as the sertoliform variant of endometrioid carcinoma and carcinoid.
  • Several good markers for this differential diagnosis have been identified, particularly inhibin, Wilms tumor 1 gene product (WT1), epithelial membrane antigen, and chromogranin; however, many available markers have limitations to some degree.
  • In the testes, SF-1 is expressed in Sertoli cells.
  • Immunohistochemical expression of this marker in ovarian sex cord-stromal tumors, including utility for differential diagnosis, has not been rigorously evaluated.
  • As an extension of our previous immunohistochemical studies of ovarian Sertoli cell tumor, expression of SF-1 and comparison with WT1 and inhibin were assessed in 111 primary ovarian tumors: 27 Sertoli cell tumors, 60 endometrioid tumors (including borderline tumors, conventional well-differentiated carcinomas, and sertoliform variants of carcinoma), and 24 carcinoids.
  • SF-1 was expressed in 100% of Sertoli cell tumors but not in endometrioid tumors or carcinoid.
  • WT1 was expressed in 100% of Sertoli cell tumors and 17% of endometrioid tumors; all carcinoids were negative.
  • Inhibin was expressed in 96% of Sertoli cell tumors and 2% of endometrioid tumors (4% of conventional well-differentiated carcinomas); all carcinoids were negative.
  • The extent of expression of all 3 markers was similar in Sertoli cell tumor but greatest for WT1: 63%, 96%, and 78% of cases showed expression of SF-1, WT1, and inhibin, respectively, in more than 50% of tumor cells.
  • Immunohistochemical composite scores combining both extent and intensity of staining in positive cases were calculated for Sertoli cell tumor (possible range: 1-12).
  • We conclude that for the differential diagnosis with endometrioid tumors and carcinoid of the ovary, SF-1 is a sensitive and specific immunohistochemical marker for Sertoli cell tumor and that SF-1 is diagnostically comparable with other good sex cord-stromal markers.
  • [MeSH-major] Carcinoma, Endometrioid / diagnosis. Ovarian Neoplasms / diagnosis. Sertoli Cell Tumor / diagnosis. Steroidogenic Factor 1 / analysis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Inhibins / analysis. Nuclear Proteins / analysis. Retrospective Studies

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  • (PMID = 18753972.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Steroidogenic Factor 1; 0 / WTAP protein, human; 57285-09-3 / Inhibins
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94. Kim O, Kim KS: Seminoma with hyperesterogenemia in a Yorkshire Terrier. J Vet Med Sci; 2005 Jan;67(1):121-3
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  • We thought that hyperesterogenemia and alopecia in this case was probably related with his seminoma, although high correlations between Sertoli cell tumor and alopecia have been reported.

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  • (PMID = 15699609.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogens
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95. Werther M, Schmelz HU, Schwerer M, Sparwasser C: [Sclerosing Sertoli cell tumor of the testis: a rare tumor. Case report and review of the literature on the subtypes of Sertoli-cell tumor]. Urologe A; 2007 Nov;46(11):1551-6
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  • [Title] [Sclerosing Sertoli cell tumor of the testis: a rare tumor. Case report and review of the literature on the subtypes of Sertoli-cell tumor].
  • [Transliterated title] Sklerosierender Sertoli-Zell-Tumor des Hodens - ein seltener Tumor : Fallvorstellung und Literaturübersicht über die Subtypen des Sertoli-Zell-Tumors.
  • Sertoli cell tumors of the testis are extremely rare (0.4-1.5% of all testicular neoplasms) and have a heterogeneous pathology.
  • Histopathologically classic, large cell calcifying and sclerosing subtypes are differentiated.Up to now, 14 cases of sclerosing Sertoli cell tumor are known.
  • While no cases of sclerosing Sertoli cell tumor with a malignant course have been reported, both other subtypes have been found to be potentially malignant.
  • In the case of malignancy the prognosis is very poor, and it is difficult to select the best treatment because there is so little experience with this type of tumor.
  • Once the diagnosis of a Sertoli cell tumor has been confirmed, exact determination of the histological subtype is essential to allow appropriate risk-adapted therapy.
  • [MeSH-major] Sertoli Cell Tumor / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Biopsy. Diagnosis, Differential. Fatty Liver, Alcoholic / blood. Humans. Male. Neoplasm Staging. Sclerosis. Testis / pathology. Ultrasonography. alpha-Fetoproteins

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  • (PMID = 17898983.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
  • [Number-of-references] 20
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96. Miwa S, Taya T: [A case of Sertoli cell tumor]. Hinyokika Kiyo; 2005 Dec;51(12):821-3
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  • [Title] [A case of Sertoli cell tumor].
  • We report a case of Sertoli cell tumor.
  • An elastic firm induration larger than a hen's egg in size was palpable on the surface of the left testis.
  • Tumor markers for testicular tumor such as human chorionic gonadotropin-beta, alpha fetoprotein, and lactate dehydrogenase were not elevated.
  • However, ultrasound showed a low echoic mass in the left testis.
  • Therefore, we performed left high orchiectomy under the diagnosis of left testicular tumor.
  • Its histology showed Sertoli cell tumor.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 16440732.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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97. Golombos D, Brison D, Sadeghi-Nejad H: Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. Urol J; 2010;7(4):281-3
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  • [Title] Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man.
  • [MeSH-major] Lymph Nodes / radiography. Retroperitoneal Neoplasms / radiography. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 21170861.001).
  • [ISSN] 1735-546X
  • [Journal-full-title] Urology journal
  • [ISO-abbreviation] Urol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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98. Young RH: Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol; 2005 Feb;18 Suppl 2:S81-98
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  • [Title] Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
  • Gonadal sex cord-stromal tumors contain some of the most morphologically interesting neoplasms of the gonads and these lead to many important issues in differential diagnosis.
  • The pathology of these tumors is reviewed with emphasis on new information, similarities and differences in the two gonads, and diagnostic problems.
  • Sertoli cell tumors occur in both gonads being more common in the testis where they usually exhibit a lobular pattern of hollow or solid tubules.
  • In the ovary, tubular differentiation is usually the predominant feature but the lobulation typically seen in the testis is generally not as striking.
  • One variant of Sertoli cell tumor, the large cell calcifying form, appears to be restricted to the male gonad and in contrast to other sex cord tumors is much more frequently bilateral and is associated in many cases with unusual clinical manifestations.
  • In females, it is in the form of the sex cord with annular tubules whereas in males, the lesion has features that are often intermediate between those of a sex cord tumor with annular tubules and a large cell calcifying Sertoli cell tumor.
  • Sertoli-Leydig cell tumors are more morphologically diverse than pure Sertoli cell tumors and for practical purposes are an issue only in ovarian pathology being exceptionally rare in the testis.
  • The classification proposed by Meyer into well, intermediate, and poor differentiation, remains important prognostically.
  • Heterologous tumors most often contain mucinous epithelium, sometimes with small foci of carcinoid or less commonly, and generally in poorly differentiated neoplasms, rhabdomyosarcoma or fetal-type cartilage.
  • Such tumors should be distinguished from pure sarcomas and teratomas.
  • The retiform neoplasms, which tend to occur in young females, may mimic serous borderline tumors or even serous carcinomas.
  • Granulosa cell tumors are much more common in females and in both gonads are divided into adult and juvenile forms.
  • In females, granulosa cell tumors and other sex cord tumors may have markedly bizarre nuclei potentially leading to overdiagnosis as more malignant neoplasms.
  • The juvenile granulosa cell tumor of the testis tends to occur in the first 6 months of life and should be carefully distinguished from the yolk sac tumor of the testis, which usually occurs in a slightly older age group.
  • Occasional sex cord-stromal tumors cannot be readily categorized into the Sertoli or granulosa families and are diagnosed as sex cord-stromal tumors unclassified.
  • In females, this is a relatively common placement for a neoplasm in a pregnant patient.
  • Unclassified tumors are overall more common in males and may entrap residual normal germ cells potentially leading to the erroneous placement of the tumor in the category of a mixed germ cell sex cord-stromal tumor.
  • From the practical viewpoint, the most helpful immunohistochemical findings are the negative staining of sex cord tumors for epithelial membrane antigen, and positive staining for inhibin and calretinin, findings that are converse to those seen in endometrioid carcinomas of the ovary, which commonly have formations that simulate sex cord tumors.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Granulosa Cell Tumor / pathology. Humans. Male. Sertoli Cell Tumor / pathology

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  • (PMID = 15502809.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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99. Jiménez JD, Cebrián JL, Guarch R, Hualde A: [Sertoli cell tumor of the testis with positive neuroendocrine markers]. Actas Urol Esp; 2010 May;34(5):481-3
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  • [Title] [Sertoli cell tumor of the testis with positive neuroendocrine markers].
  • [Transliterated title] Tumor testicular de células de Sertoli con marcadores neuroendocrinos positivos.
  • [MeSH-major] Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 20470725.001).
  • [ISSN] 1699-7980
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Synaptophysin
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100. National Toxicology Program: Toxicology and carcinogenesis studies of cumene (CAS No. 98-82-8) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2009 Feb;(542):1-200
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  • Adenomas of the respiratory epithelium of the nose were observed in male and female rats, and male rats had increased incidences of renal tubule adenoma or carcinoma (combined) and interstitial cell adenoma of the testis.
  • Adenomas and carcinomas of the lung were markedly increased in male and female mice exposed to cumene.
  • The rate of liver neoplasms was also increased in exposed female mice, and a few hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland were seen in male mice exposed to the highest concentration of cumene.
  • CONCLUSIONS: We conclude that the increased occurrences of adenomas of the epithelium of the nose in male and female rats, of renal tubule adenoma or carcinoma (combined), of adenomas and carcinomas of the lung in male and female mice, and of liver neoplasms in female mice were caused by exposure to cumene.
  • The occurrence of interstitial cell adenoma of the testis in male rats and hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland in male mice may also have been associated with exposure to cumene.

  • Hazardous Substances Data Bank. Isopropylbenzene .
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  • (PMID = 19340095.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzene Derivatives; 8Q54S3XE7K / cumene
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