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96. Miwa S, Taya T: [A case of Sertoli cell tumor]. Hinyokika Kiyo; 2005 Dec;51(12):821-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of Sertoli cell tumor].
  • We report a case of Sertoli cell tumor.
  • An elastic firm induration larger than a hen's egg in size was palpable on the surface of the left testis.
  • Tumor markers for testicular tumor such as human chorionic gonadotropin-beta, alpha fetoprotein, and lactate dehydrogenase were not elevated.
  • However, ultrasound showed a low echoic mass in the left testis.
  • Therefore, we performed left high orchiectomy under the diagnosis of left testicular tumor.
  • Its histology showed Sertoli cell tumor.
  • [MeSH-major] Sertoli Cell Tumor. Testicular Neoplasms

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  • (PMID = 16440732.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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97. Golombos D, Brison D, Sadeghi-Nejad H: Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. Urol J; 2010;7(4):281-3
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  • [Title] Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man.
  • [MeSH-major] Lymph Nodes / radiography. Retroperitoneal Neoplasms / radiography. Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 21170861.001).
  • [ISSN] 1735-546X
  • [Journal-full-title] Urology journal
  • [ISO-abbreviation] Urol J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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98. Young RH: Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol; 2005 Feb;18 Suppl 2:S81-98
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  • [Title] Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
  • Gonadal sex cord-stromal tumors contain some of the most morphologically interesting neoplasms of the gonads and these lead to many important issues in differential diagnosis.
  • The pathology of these tumors is reviewed with emphasis on new information, similarities and differences in the two gonads, and diagnostic problems.
  • Sertoli cell tumors occur in both gonads being more common in the testis where they usually exhibit a lobular pattern of hollow or solid tubules.
  • In the ovary, tubular differentiation is usually the predominant feature but the lobulation typically seen in the testis is generally not as striking.
  • One variant of Sertoli cell tumor, the large cell calcifying form, appears to be restricted to the male gonad and in contrast to other sex cord tumors is much more frequently bilateral and is associated in many cases with unusual clinical manifestations.
  • In females, it is in the form of the sex cord with annular tubules whereas in males, the lesion has features that are often intermediate between those of a sex cord tumor with annular tubules and a large cell calcifying Sertoli cell tumor.
  • Sertoli-Leydig cell tumors are more morphologically diverse than pure Sertoli cell tumors and for practical purposes are an issue only in ovarian pathology being exceptionally rare in the testis.
  • The classification proposed by Meyer into well, intermediate, and poor differentiation, remains important prognostically.
  • Heterologous tumors most often contain mucinous epithelium, sometimes with small foci of carcinoid or less commonly, and generally in poorly differentiated neoplasms, rhabdomyosarcoma or fetal-type cartilage.
  • Such tumors should be distinguished from pure sarcomas and teratomas.
  • The retiform neoplasms, which tend to occur in young females, may mimic serous borderline tumors or even serous carcinomas.
  • Granulosa cell tumors are much more common in females and in both gonads are divided into adult and juvenile forms.
  • In females, granulosa cell tumors and other sex cord tumors may have markedly bizarre nuclei potentially leading to overdiagnosis as more malignant neoplasms.
  • The juvenile granulosa cell tumor of the testis tends to occur in the first 6 months of life and should be carefully distinguished from the yolk sac tumor of the testis, which usually occurs in a slightly older age group.
  • Occasional sex cord-stromal tumors cannot be readily categorized into the Sertoli or granulosa families and are diagnosed as sex cord-stromal tumors unclassified.
  • In females, this is a relatively common placement for a neoplasm in a pregnant patient.
  • Unclassified tumors are overall more common in males and may entrap residual normal germ cells potentially leading to the erroneous placement of the tumor in the category of a mixed germ cell sex cord-stromal tumor.
  • From the practical viewpoint, the most helpful immunohistochemical findings are the negative staining of sex cord tumors for epithelial membrane antigen, and positive staining for inhibin and calretinin, findings that are converse to those seen in endometrioid carcinomas of the ovary, which commonly have formations that simulate sex cord tumors.
  • [MeSH-major] Ovarian Neoplasms / pathology. Sex Cord-Gonadal Stromal Tumors / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Granulosa Cell Tumor / pathology. Humans. Male. Sertoli Cell Tumor / pathology

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  • (PMID = 15502809.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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99. Jiménez JD, Cebrián JL, Guarch R, Hualde A: [Sertoli cell tumor of the testis with positive neuroendocrine markers]. Actas Urol Esp; 2010 May;34(5):481-3
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  • [Title] [Sertoli cell tumor of the testis with positive neuroendocrine markers].
  • [Transliterated title] Tumor testicular de células de Sertoli con marcadores neuroendocrinos positivos.
  • [MeSH-major] Sertoli Cell Tumor / pathology. Testicular Neoplasms / pathology

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  • (PMID = 20470725.001).
  • [ISSN] 1699-7980
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Synaptophysin
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100. National Toxicology Program: Toxicology and carcinogenesis studies of cumene (CAS No. 98-82-8) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2009 Feb;(542):1-200
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  • Adenomas of the respiratory epithelium of the nose were observed in male and female rats, and male rats had increased incidences of renal tubule adenoma or carcinoma (combined) and interstitial cell adenoma of the testis.
  • Adenomas and carcinomas of the lung were markedly increased in male and female mice exposed to cumene.
  • The rate of liver neoplasms was also increased in exposed female mice, and a few hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland were seen in male mice exposed to the highest concentration of cumene.
  • CONCLUSIONS: We conclude that the increased occurrences of adenomas of the epithelium of the nose in male and female rats, of renal tubule adenoma or carcinoma (combined), of adenomas and carcinomas of the lung in male and female mice, and of liver neoplasms in female mice were caused by exposure to cumene.
  • The occurrence of interstitial cell adenoma of the testis in male rats and hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland in male mice may also have been associated with exposure to cumene.

  • Hazardous Substances Data Bank. Isopropylbenzene .
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  • (PMID = 19340095.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzene Derivatives; 8Q54S3XE7K / cumene
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