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1. Yamamoto T, Mamada A: Syringocystadenoma papilliferum arising on the thigh without connection to the overlying epidermis. Am J Dermatopathol; 2008 Feb;30(1):84-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Epidermis / pathology. Sweat Gland Neoplasms / pathology. Thigh / pathology

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  • (PMID = 18212554.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Dubb M, Michelow P: Cytologic features of hidradenoma in fine needle aspiration biopsies. Acta Cytol; 2009 Mar-Apr;53(2):179-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic features of hidradenoma in fine needle aspiration biopsies.
  • OBJECTIVE: To review the cytologic features of hidradenoma to describe criteria that may aid in identification of these tumors at the time of aspiration and allow for a more specific diagnosis than the umbrella term of benign skin adnexal tumor.
  • Fine needle aspiration (FNA) of these lesions showed the presence of benign skin adnexal tumors.
  • RESULTS: The following cytomorphologic findings are consistent with the diagnosis of hidradenoma: a cystic component to the aspirate as represented by amorphous background material with or without foam cells and epithelial duct-like cells and tubular structures.
  • CONCLUSION: Knowledge of the cytologic features of hidradenoma will allow for correct management of the patient and prevent misdiagnosis as a malignant tumor.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19365971.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Nash JW, Barrett TL, Kies M, Ross MI, Sneige N, Diwan AH, Lazar AJ: Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. J Cutan Pathol; 2007 Jan;34(1):49-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 'benign' nodule had been excised from this location 8 years prior.
  • Features of a clear cell hidradenoma were noted focally.
  • Negative stains included villin, TTF-1, CDX2, S-100 protein, vimentin, gross cystic disease fluid protein 15 (GCDFP-15), mammoglobulin, and MUC2.
  • We believe this to be the first demonstration of Her-2/neu amplification in a malignant skin adnexal tumor.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. Gene Amplification. Genes, erbB-2. In Situ Hybridization, Fluorescence. Lymphatic Metastasis / genetics. Sweat Gland Neoplasms / pathology


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4. Bumgardner AC, Hsu S, Nunez-Gussman JK, Schwartz MR: Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap. Int J Dermatol; 2005 May;44(5):415-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Basal Cell / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 15869542.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Cihocki LM, Divers TJ, Johnson AL, Warren AL, Schramme M, Rassnick KM, Scott DW: A case of multiple epitrichial sweat gland ductal carcinomas in a horse. Vet Dermatol; 2007 Apr;18(2):134-7
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  • [Title] A case of multiple epitrichial sweat gland ductal carcinomas in a horse.
  • This case report describes a rare epitrichial sweat gland ductal carcinoma in a 14-year-old horse and is the first report of multiple carcinomas of this type in horses.
  • [MeSH-major] Adenoma, Sweat Gland / veterinary. Horse Diseases / diagnosis. Neoplasms, Multiple Primary / veterinary. Sweat Gland Neoplasms / veterinary

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  • (PMID = 17355430.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
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6. Uke MS, Kulkarni MB, Ajit D, Gujral S: Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):907-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of hidradenoma papilliferum of the vulva on cytologic smears: a case report.
  • BACKGROUND: Hidradenoma papilliferum is a rare benign tumor of the vulva that occurs mainly in women in the skin of the anogenital region.
  • Repeat vulvar smears showed mainly groups and clusters of benign-looking glandular cells and were interpreted as a benign tumor.
  • Subsequent histology confirmed the diagnosis of hidradenoma papilliferum.
  • CONCLUSION: This case highlights the cytologic features of hidradenoma papilliferum on cytologic smears.
  • [MeSH-major] Acrospiroma / diagnosis. Cytological Techniques. Sweat Gland Neoplasms / diagnosis. Vulva / pathology

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  • (PMID = 21053567.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Missall TA, Burkemper NM, Jensen SL, Hurley MY: Immunohistochemical differentiation of four benign eccrine tumors. J Cutan Pathol; 2009 Feb;36(2):190-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical differentiation of four benign eccrine tumors.
  • BACKGROUND: The histogenesis and differentiation of eccrine tumors, including cylindroma, poroma, spiradenoma and syringoma, remains controversial.
  • METHODS: Ten examples each of normal eccrine structures and of four benign eccrine tumors are analyzed with antibodies to cytokeratin (CK) 7, CD34, CK6, CK10, smooth muscle actin (SMA) and CD10.
  • These markers represent two different immunohistochemical stains for each part of the eccrine structure; CK7 and CD34 stain the secretory coil, CK6 and CK10 stain the straight duct and SMA and CD10 stain the myoepithelial cells.
  • This redundancy in staining is performed on four benign eccrine tumors to better interpret the existing literature.
  • SMA appears to be a more specific marker for myoepithelial cells surrounding normal eccrine coils, and none of the studied tumors express SMA or CD10.
  • CONCLUSIONS: Our studies suggest that syringomas are tumors of the eccrine duct, while cylindromas and spiradenomas are tumors of the secretory coil.
  • [MeSH-major] Adenoma, Sweat Gland. Antigens, CD34 / biosynthesis. Biomarkers, Tumor / biosynthesis. Keratins / biosynthesis. Neprilysin / biosynthesis. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Humans. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 18564284.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 68238-35-7 / Keratins; EC 3.4.24.11 / Neprilysin
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8. Premalata CS, Kumar RV, Malathi M, Shenoy AM, Nanjundappa N: Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. Int J Dermatol; 2007 Mar;46(3):306-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • X-Ray of the skull was normal and no evidence of metastatic disease was identified.
  • The specimen of the initial surgery consisted of skin-covered tissue with an exophytic firm growth measuring 6 x 5 x 4 cm.
  • The skin surface was rough with areas of ulceration.
  • The third lesion was a spindle cell sarcoma which formed the major part of the lesion, diffusely infiltrating the dermis and subcutaneous tissue, elevating and ulcerating the overlying skin.
  • The tumor cells were seen encircling the sweat glands, without destroying them (Fig. 3).
  • The wide excision specimen of the recurrent swelling consisted of a skin-covered nodule with ulceration, measuring 3 x 4 x 3 cm, with a gray-white whorled cut surface.
  • Multiple sections showed only spindle cell sarcoma infiltrating the skin and subcutaneous tissue, morphologically similar to the earlier tumor, with ulceration of the overlying skin.
  • The patient received postoperative radiotherapy and is disease free 8 months after diagnosis.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Leiomyosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Scalp. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


9. Al-Faky YH, Al-Mosallam AR, Al-Sohaibani MO: Periocular hidradenoma papilliferum. Saudi J Ophthalmol; 2009 Oct;23(3-4):211-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periocular hidradenoma papilliferum.
  • Hidradenoma is a benign adnexal neoplasm originating from the apocrine sweat gland, and is almost exclusively detectable in the skin of the anogenital area of middle-aged white females after puberty.
  • Ectopic hidradenoma papilliferum, which involves the skin away from the anogenital region, is exceedingly rare, and can also affect males.

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  • (PMID = 23960862.001).
  • [ISSN] 1319-4534
  • [Journal-full-title] Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
  • [ISO-abbreviation] Saudi J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3729807
  • [Keywords] NOTNLM ; Childhood / Ectopic / Hidradenoma papilliferum
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10. Simeonov RS, Simeonova GP: Use of quantitative analysis as a method for differentiation between canine cutaneous apocrine adenomas and apocrine carcinomas on cytological smears. J Vet Med A Physiol Pathol Clin Med; 2007 Nov;54(9):542-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of quantitative analysis as a method for differentiation between canine cutaneous apocrine adenomas and apocrine carcinomas on cytological smears.
  • Eight canine cutaneous adenomas and eight canine cutaneous carcinomas were analysed by computer-assisted nuclear morphometry in Hemacolor-stained cytological specimens.
  • The results indicated an increase in the mean values of investigated parameters from canine cutaneous apocrine adenomas (MNA, 75.65+/-2.22; MNP, 31.05+/-0.55; MND, 9.62+/-0.14; NR, 1.10+/-0.009) to canine cutaneous apocrine carcinomas (MNA, 88.78+/-11.29; MNP, 34.38+/-2.43; MND, 10.43+/-0.76; NR, 1.21+/-0.07).
  • The statistical analysis revealed statistically significant differences between benign and malignant neoplastic cells (P<0.01).
  • The results indicated that the computerized morphometry could be used as an effective auxiliary tool for differential diagnosis between canine cutaneous adenomas and carcinomas on cytological smears.
  • [MeSH-major] Adenoma / veterinary. Apocrine Glands / cytology. Carcinoma / veterinary. Cell Nucleus / pathology. Dog Diseases / pathology. Sweat Gland Neoplasms / veterinary

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  • (PMID = 17931233.001).
  • [ISSN] 0931-184X
  • [Journal-full-title] Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
  • [ISO-abbreviation] J Vet Med A Physiol Pathol Clin Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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11. Bollée G, Patey N, Cazajous G, Robert C, Goujon JM, Fakhouri F, Bruneval P, Noël LH, Knebelmann B: Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib. Nephrol Dial Transplant; 2009 Feb;24(2):682-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 44-year-old woman with a history of malignant skin hidradenoma was started on sunitinib for refractory disease.
  • [MeSH-minor] Adenoma, Sweat Gland / drug therapy. Adult. Antineoplastic Agents / adverse effects. Female. Humans. Protein Kinase Inhibitors / adverse effects. Skin Neoplasms / drug therapy

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  • [CommentIn] Nephrol Dial Transplant. 2009 Jun;24(6):2002-3 [19332867.001]
  • (PMID = 19054798.001).
  • [ISSN] 1460-2385
  • [Journal-full-title] Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • [ISO-abbreviation] Nephrol. Dial. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Protein Kinase Inhibitors; 0 / Pyrroles; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / sunitinib
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12. Bezić J, Forempoher G, Poljicanin A, Gunjaca G: Apocrine adenoma of the breast coexistent with invasive carcinoma. Pathol Res Pract; 2007;203(11):809-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apocrine adenoma of the breast coexistent with invasive carcinoma.
  • We describe a case of apocrine adenoma with simultaneous occurrence of invasive ductal carcinoma in the breast of a 53-year-old woman.
  • Apocrine adenoma affecting the breast is very rare.
  • The patient presented with a palpable nodule with skin retraction in her right breast, where ultrasound examination identified a 5-mm hypoechogenic nodule.
  • The ultrasound also revealed in the surrounding breast parenchyma an additional abnormal finding suggestive of carcinoma.
  • Histologic examination of the excised specimen showed that the hypoechogenic nodule represented an apocrine adenoma in proximity to the invasive ductal breast carcinoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Breast Neoplasms / pathology. Carcinoma, Ductal, Breast / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17936522.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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13. Laube S, Suarez V, Hardwick N: A cluster of papules on the buttock of a teenager. Clin Exp Dermatol; 2005 Mar;30(2):197-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 15725259.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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14. Qiu RX, Gu LL, Zhang Q: [A case of nasal adenoma apocrine]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Dec;43(12):959-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of nasal adenoma apocrine].
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Nose Neoplasms / pathology

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  • (PMID = 19141253.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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15. Agarwal S, Agarwal K, Kathuria P, Jain M, Chauhan DS, Prakash O: Cytomorphological features of nodular hidradenoma highlighting eccrine differentiation: a case report. Indian J Pathol Microbiol; 2006 Jul;49(3):411-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytomorphological features of nodular hidradenoma highlighting eccrine differentiation: a case report.
  • We report a case of nodular hidradenoma in a 90 year old male, presenting with an eyelid swelling.
  • The cytomorphological features are described with special emphasis on cytoplasmic granularity and tubule formation as an important feature in diagnosing and differentiating eccrine tumors from other adnexal neoplasms on FNAC.
  • [MeSH-major] Acrospiroma / pathology. Eyelids / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17001903.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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16. Ogawa R, Mitsuhashi K, Oki K, Hyakusoku H: A rare case of chondroid syringoma arising from the lower eyelid with ectropion. Plast Reconstr Surg; 2006 Nov;118(6):137e-140e
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Eyelids. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17051093.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Kazakov DV, Nemcova J, Mikyskova I, Belousova IE, Vazmitel M, Michal M: Human papillomavirus in lesions of anogenital mammary-like glands. Int J Gynecol Pathol; 2007 Oct;26(4):475-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The lesions included 3 fibroadenomas, 2 adenosis tumors, 1 invasive ductal carcinoma, 1 tubulolobular carcinoma, 2 hidradenoma papilliferum with prominent cystic change rendering a cystadenoma appearance and oxyphilic metaplasia, and 7 cases of extramammary Paget disease.
  • All 3 fibroadenomas, both adenosis tumors, both hidradenoma papilliferum, and the tubulolobular carcinoma proved negative for HPV DNA.
  • In 2 of the 7 patients with extramammary Paget disease, there was HPV DNA present in the lesional tissue, typed as HPV-6 (LiPA) and a type which was closely related to HPV-21 and HPV-24 (FAP 6085-6319), whereas the remaining 5 cases tested negative.

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  • (PMID = 17885501.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Arias D, Castellano VM, Córdoba S, Miñano R, Martínez D, Borbujo JM: [Atypical presentation of syringocystoadenoma papilliferum]. Actas Dermosifiliogr; 2006 Dec;97(10):647-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Siringocistoadenoma papilífero de presentación atípica.
  • Syringocystoadenoma papilliferum is benign adnexal tumor derived from the sweat glands that is located in the head and neck in 70-80% of patients, and commonly presents as a papule or a solitary nodule.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Neoplasms, Second Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17173827.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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19. Souvatzidis P, Sbano P, Mandato F, Fimiani M, Castelli A: Malignant nodular hidradenoma of the skin: report of seven cases. J Eur Acad Dermatol Venereol; 2008 May;22(5):549-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant nodular hidradenoma of the skin: report of seven cases.
  • BACKGROUND: Malignant nodular hidradenoma (MNH) is an infrequent, highly malignant, primary skin tumour derived from eccrine sweat glands.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy. Fatal Outcome. Female. Humans. Male. Middle Aged. Prognosis. Skin / pathology

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  • (PMID = 18410617.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 29
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20. Lee SY, Hwang SS, Kim HJ, Jung JH: Eccrine acrospiroma of inguinal area: Computed tomography findings. J Comput Assist Tomogr; 2006 Mar-Apr;30(2):223-5
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  • [Title] Eccrine acrospiroma of inguinal area: Computed tomography findings.
  • Eccrine acrospiroma is a tumor originating from the sweat glands.
  • The computed tomography findings of eccrine acrospiroma in the right inguinal area are presented.
  • Eccrine acrospiroma should be considered in the differential diagnosis of a subcutaneous cystic mass with an internal solid nodule.
  • [MeSH-major] Acrospiroma / radiography. Sweat Gland Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 16628036.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. El Demellawy D, Daya D, Alowami S: Clear cell hidradenoma: an unusual vulvar tumor. Int J Gynecol Pathol; 2008 Jul;27(3):457-60
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  • [Title] Clear cell hidradenoma: an unusual vulvar tumor.
  • Clear cell hidradenoma (CCH) is a benign skin appendageal tumor.
  • Most cases occur in the skin of the head and face.
  • Although most cases are benign, occasional cases with malignant transformation have been reported.
  • Although rare, inclusion of CCH should be included in the differential diagnosis of benign solid and clear cell tumors of the vulvar skin.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18580328.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V: Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol; 2008 Mar-Apr;29(2):142-6
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  • [Title] Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review.
  • Ceruminal glands are modified sweat glands of the skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma.
  • An alternative theory holds that pleomorphic adenomas may well arise from ectopic salivary tissue present in the external ear canal.
  • These tumors are very rare and usually have a benign course.
  • In this report, we describe an unusual case of pleomorphic adenoma of the external auditory canal associated with chronic infection of the middle ear.
  • Subsequent biopsy and histologic examination revealed pleomorphic adenoma of the external ear canal, possibly with malignant elements.
  • Magnetic resonance imaging showed no intracranial extension or any association with the adjacent parotid gland.
  • The patient underwent modified radical mastoidectomy and complete resection of the tumor and the entire skin of the external auditory canal.
  • CONCLUSIONS: Pleomorphic adenoma is an extremely rare tumor arising from the ceruminal glands of the external ear canal.
  • Nonspecific presentation and difficult histologic diagnosis characterize this benign neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Ear, External / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18314029.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 13
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23. Cho KE, Son EJ, Kim JA, Youk JH, Kim EK, Kwak JY, Jeong J: Clear cell hidradenoma of the axilla: a case report with literature review. Korean J Radiol; 2010 Jul-Aug;11(4):490-2
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  • [Title] Clear cell hidradenoma of the axilla: a case report with literature review.
  • Clear cell hidradenoma is an uncommon benign skin appendageal tumor that typically involves the dermal layer of the head, face, and extremities.
  • We present a case of clear cell hidradenoma of the axillary tail with radiological findings and a literature review.
  • [MeSH-major] Adenoma, Sweat Gland / radiography. Adenoma, Sweat Gland / ultrasonography. Axilla. Sweat Gland Neoplasms / radiography. Sweat Gland Neoplasms / ultrasonography

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  • [Cites] Br J Radiol. 2007 Jan;80(949):e27-9 [17267467.001]
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  • (PMID = 20592936.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2893323
  • [Keywords] NOTNLM ; Axilla mass / Hidradenoma / Ultrasonography
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24. Magliulo G, Bertin S: Adenoma of the ceruminous gland. Otolaryngol Head Neck Surg; 2010 Sep;143(3):459-60
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  • [Title] Adenoma of the ceruminous gland.
  • [MeSH-major] Adenoma / pathology. Cerumen. Ear Canal. Ear Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 20723789.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • [Transliterated title] Siringoma condroide: revisión clínica e histológica de ocho casos.
  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • It can be classified as eccrine and apocrine according to its pathological characteristics.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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26. Ko CJ, Cochran AJ, Eng W, Binder SW: Hidradenocarcinoma: a histological and immunohistochemical study. J Cutan Pathol; 2006 Nov;33(11):726-30
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  • The diagnosis of hidradenocarcinoma is difficult due to a combination of factors including inconsistent nomenclature/ classification, rarity of the neoplasm, and variable morphology of cells composing the neoplasm.
  • We evaluated six cases of hidradenocarcinoma histologically and immunohistochemically using antibodies to gross cystic disease fluid protein-15 (GCDFP-15), carcino-embryonic antigen (CEA), epithelial membrane antigen (EMA), S-100 protein, keratin AE1/3, cytokeratin 5/6, p53, bcl-1, bcl-2, and Ki67.
  • Histology suggested concurrent eccrine and apocrine differentiation of the cases.
  • In making the diagnosis of hidradenocarcinoma, it may be unnecessary to separate hidradenocarcinoma into eccrine and apocrine categories, and although Ki67 and p53 may be helpful, histological parameters remain paramount.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Ki-67 Antigen / metabolism. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17083691.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; 68238-35-7 / Keratins
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27. Kazakov DV, Kutzner H, Spagnolo DV, Kempf W, Zelger B, Mukensnabl P, Michal M: Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma). Am J Dermatopathol; 2008 Feb;30(1):21-6
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  • Six lesions had the silhouette of a classical poroma, 3 of poroid hidradenoma and 1 of dermal duct tumor.
  • Our study supports previous findings that sebaceous differentiation can be identified not only in classical poroma but also in the related lesions known as dermal duct tumor and poroid hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Sebaceous Glands / pathology. Skin Neoplasms / pathology

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  • (PMID = 18212539.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Ishida M, Kojima F, Kushima R, Kakutani A, Okabe H: [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin]. Rinsho Byori; 2006 Aug;54(8):781-4
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  • [Title] [Case of clear cell hidradenoma with mucinous metaplasia in the forehead--immunohistochemical analysis of the mucin].
  • Mucinous metaplasia rarely develops in the non-neoplastic skin or its appendages, and almost exclusively confined to the genitalia, palms and soles.
  • Here we report a new case of clear cell hidradenoma with mucinous metaplasia in the forehead.
  • Our immunohistochemical analysis revealed MUC5AC in the mucinous metaplastic cells of this tumor as in the extramammary Paget's disease, and expression of this gastric foveolar epithelial mucin core protein in these two neoplastic conditions seem to related to their common apocrine origin.
  • [MeSH-major] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Forehead. Mucins / analysis. Sweat Gland Neoplasms / metabolism. Sweat Gland Neoplasms / pathology

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  • (PMID = 16989395.001).
  • [ISSN] 0047-1860
  • [Journal-full-title] Rinsho byori. The Japanese journal of clinical pathology
  • [ISO-abbreviation] Rinsho Byori
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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29. Guan Y, Xiao Y, Ji HA, Xue CW, Li P: [Poroid hidradenoma: a case report]. Zhonghua Bing Li Xue Za Zhi; 2006 Jun;35(6):378-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Poroid hidradenoma: a case report].
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Skin Neoplasms / pathology

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  • (PMID = 16834920.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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30. Ohi Y, Umekita Y, Rai Y, Kukita T, Sagara Y, Sagara Y, Takahama T, Andou M, Sagara Y, Yoshida A, Yoshida H: Clear cell hidradenoma of the breast: a case report with review of the literature. Breast Cancer; 2007;14(3):307-11
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  • [Title] Clear cell hidradenoma of the breast: a case report with review of the literature.
  • Clear cell hidradenoma of the breast is rare.
  • Histological examination demonstrated characteristic histological features of clear cell hidradenoma, such as proliferation of uniform epithelial cells, clear or slightly eosinophilic cytoplasm, and cuboidal cell-lined ductal structures.
  • These features were consistent with clear cell hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Breast Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17690510.001).
  • [ISSN] 1340-6868
  • [Journal-full-title] Breast cancer (Tokyo, Japan)
  • [ISO-abbreviation] Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 16
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31. Siddaraju N, Murugan P, Wilfred CD, Choudhury N, Basu D: Preoperative cytologic diagnosis of chondroid syringoma. Acta Cytol; 2009 Sep-Oct;53(5):607-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19798896.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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32. Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T: Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer; 2007 Sep;46(9):813-9
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  • MLL-MAML2 in secondary AML/MDS and MECT1-MAML2 in mucoepithelioid carcinoma, benign Wartin's tumor, and clear cell hidradenoma consist of the same COOH-terminal part of MAML2.


33. Gatti A, di Meo N, Trevisan G: Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. Acta Dermatovenerol Alp Pannonica Adriat; 2010 Dec;19(4):23-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma.
  • Eccrine acrospiroma, better known as eccrine poroma, is a benign adnexal neoplasm of the skin.
  • [MeSH-major] Acrospiroma / pathology. Dermoscopy. Melanoma / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


34. Volmar KE, Cummings TJ, Wang WH, Creager AJ, Tyler DS, Xie HB: Clear cell hidradenoma: a mimic of metastatic clear cell tumors. Arch Pathol Lab Med; 2005 May;129(5):e113-6
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  • [Title] Clear cell hidradenoma: a mimic of metastatic clear cell tumors.
  • Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma.
  • Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma.
  • Knowing the cytologic features of primary skin adnexal neoplasms helps distinguish them from cutaneous metastases, which are more commonly referred for fine-needle aspiration biopsy evaluation.
  • We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 15859654.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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35. Angulo J, González-Guerra E, Vargas-Machuca I, Fariña MC, Martín L, Requena L: [Multiple linear spiradenoma with a linear distribution]. Actas Dermosifiliogr; 2006 Jan-Feb;97(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16540048.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 18
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36. Kim MS, Lee JH, Lee WM, Son SJ: A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus. Ann Dermatol; 2010 Aug;22(3):319-22
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  • [Title] A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus.
  • Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor.

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  • (PMID = 20711270.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917687
  • [Keywords] NOTNLM ; Nevus sebaceus / Syringocystadenoma papilliferum / Tubular apocrine adenoma
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37. Toulemonde A, Croue A, Rodien P, Verret JL: [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient]. Ann Dermatol Venereol; 2006 Dec;133(12):1005-8
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  • [Title] [Malignant nodular hidradenoma and multiple nodular hidradenomas in a hypogonadic patient].
  • BACKGROUND: We report a case of multiple benign nodular hidradenomas associated with malignant nodular hidradenoma in a hypogonadic patient.
  • CASE-REPORT: A 49 year-old man presented 11 benign nodular hidradenomas in the pectoral region.
  • A malignant nodular hidradenoma had recently appeared in this region some distance from the pre-existing benign modular hidradenomas.
  • Large numbers of estrogen receptors were demonstrated in each of the benign nodular hidradenomas.
  • The malignant nodular hidradenoma mass was unavailable and screening for these receptors was not possible.
  • DISCUSSION: Cases of multiple nodular hidradenoma are extremely rare: we have seen only two.
  • To the best of our knowledge, there have been no reports to date of combined malignant nodular hidradenoma and multiple benign nodular hidradenoma.
  • However, the presence of estrogen receptors has occasionally been demonstrated in benign nodular hidradenomas.
  • Our patient's endocrine disease may have played a role in the presentation of multiple hidradenomas, but this cannot be demonstrated.
  • [MeSH-major] Adenoma, Sweat Gland / complications. Hypogonadism / complications. Sweat Gland Neoplasms / complications

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  • (PMID = 17185934.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Receptors, Estrogen
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38. Tey HL, Chong WS, Wong SN: Leprosy-associated eccrine syringofibroadenoma of Mascaro. Clin Exp Dermatol; 2007 Sep;32(5):533-5
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  • [Title] Leprosy-associated eccrine syringofibroadenoma of Mascaro.
  • Eccrine syringofibroadenoma of Mascaro is a rare benign tumour.
  • Histology was consistent with eccrine syringofibroadenoma.
  • To our knowledge, this is the first reported case of multiple eccrine syringofibroadenomata occurring in association with leprosy.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Fibroadenoma / pathology. Leprosy, Lepromatous / complications. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Age Factors. Aged. Disease Progression. Female. Follow-Up Studies. Humans

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  • (PMID = 17459067.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Novak NP, Kaić G, Tomasović-Loncarić C, Zic R, Skoro M, Ostović KT: Fine-needle aspiration cytology of apocrine hidradenoma. Coll Antropol; 2010 Jun;34(2):671-4
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  • [Title] Fine-needle aspiration cytology of apocrine hidradenoma.
  • An apocrine hidradenoma is a benign adnexal neoplasm, usually covered by intact skin, but may show superficial ulceration and serous discharge.
  • We described cytomorphologic features of cutaneous nodule that might be a lead to the cytologic diagnosis of hidradenoma, but primary or secondary malignant tumour has been ruled out first.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Skin Neoplasms / pathology. Skin Neoplasms / surgery

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  • (PMID = 20698151.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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40. Kuwabara H, Haginomori S, Takamaki A, Ito K, Takenaka H, Kurisu Y, Tsuji M, Mori H: Lipomatous pleomorphic adenoma of the ceruminous gland. Pathol Int; 2006 Jan;56(1):51-3
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  • [Title] Lipomatous pleomorphic adenoma of the ceruminous gland.
  • A case of lipomatous pleomorphic adenoma in the ceruminous gland is reported.
  • This case demonstrates the peculiar location of a lipomatous pleomorphic adenoma in the external auditory canal.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / pathology. Ear Canal. Ear Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16398681.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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41. Smiri KH, Fenniche S, Marrak H, Daoud L, Debbiche A, Ben Ayed M, Mokhtar I: [Chondroid syringoma]. Tunis Med; 2005 Jun;83(6):372-4
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  • All patients presented with a single painless skin lesion of about 1,5 cm on the face, lasting for 14 months on average.
  • Chondroid syringoma is a benign sweat gland tumor.
  • Diagnosis can always be confirmed by histology which shows tubuloalveolar and gland like structures with two or more cuboidal cell lines in a fibroadipoid or chondroid stroma that is positively stained for Alcian blue.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Disease Progression. Humans. Male. Middle Aged. Patient Satisfaction. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 16156416.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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42. Yamakoshi T, Makino T, Watanabe H, Furuichi M, Matsui K, Shimizu T: A case of giant vascular eccrine spiradenoma with unusual clinical features. Clin Exp Dermatol; 2009 Oct;34(7):e250-1
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  • [Title] A case of giant vascular eccrine spiradenoma with unusual clinical features.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Eccrine Glands. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19323658.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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43. Abdulla AN, Covert AA, Grantmyre JE: Scrotal syringocystadenoma papilliferum: case report. Can J Urol; 2009 Jun;16(3):4684-6
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  • Syringocystadenoma papilliferum (SCAP) is a benign rare adnexal skin neoplasm, which in a third of cases arises from a nevus sebaceous and is most commonly found on the head and neck and in very rare instances found on the genitalia.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Scrotum / pathology. Skin Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19497181.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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44. Gilaberte Y, Grasa MP, Carapeto FJ: Clear cell hidradenoma. J Am Acad Dermatol; 2006 May;54(5 Suppl):248-9
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  • [Title] Clear cell hidradenoma.
  • [MeSH-major] Acrospiroma / pathology. Leg. Sweat Gland Neoplasms / pathology

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  • [CommentOn] J Am Acad Dermatol. 2000 Apr;42(4):693-5 [10727324.001]
  • (PMID = 16631962.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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45. Retamar RA, Stengel F, Saadi ME, Kien MC, Della Giovana P, Cabrera H, Chouela EN: Brooke-Spiegler syndrome - report of four families: treatment with CO2 laser. Int J Dermatol; 2007 Jun;46(6):583-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Brooke-Spiegler syndrome is a well known but rare cutaneous disorder characterized by the presence of multiple trichoepitheliomas and cylindromas.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Carcinoma, Adenoid Cystic / surgery. Laser Therapy. Neoplasms, Adnexal and Skin Appendage / surgery. Neoplasms, Multiple Primary / surgery. Neoplastic Syndromes, Hereditary / surgery. Skin Neoplasms / surgery

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  • (PMID = 17550556.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • Brooke-Spiegler syndrome is an autosomal dominantly inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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47. Kazakov DV, Magro G, Kutzner H, Spagnolo DV, Yang Y, Zaspa O, Mukensnabl P, Michal M: Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: a clinicopathological study of 6 cases. Am J Dermatopathol; 2008 Oct;30(5):436-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18806484.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-14
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48. Choudhury M, Agarwal C, Aggarwal M, Pathania OP, Goel N: Clinicopathological profile of an unusual case of chondroid syringoma: a case report. Indian J Pathol Microbiol; 2007 Apr;50(2):349-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma or mixed tumor of the skin is an uncommon tumor that typically presents as small, solitary, slow growing, firm, subcutaneous or intracutaneous nodule.
  • FNAC and excision biopsy revealed benign chondroid syringoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology

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  • (PMID = 17883069.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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49. El-Naggar AK: Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205. Adv Anat Pathol; 2006 Mar;13(2):80-2
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  • [Title] Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. 2005;43:202-205.
  • [MeSH-major] Adenoma, Sweat Gland / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics. Sweat Gland Neoplasms / genetics. Transcription Factors / genetics. Translocation, Genetic

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  • (PMID = 16670462.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Transcription Factors
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50. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


51. Schaller J, Rytina E, Rütten A, Hendricks C, Ha T, Requena L: Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases. J Cutan Pathol; 2010 Sep;37(9):1002-9
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  • [Title] Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases.
  • Both from a clinical and from a histopathological point of view, our two cases showed some similarities with those previously described in patients with Nicolau-Balus syndrome, Rombo syndrome, and so-called eccrine-pilar hamartoma.
  • Dermatologists and dermatopathologists should be aware of this disorder to avoid overdiagnosis of and inappropriate treatment for MAC.
  • [MeSH-major] Adenoma / diagnosis. Facial Dermatoses / pathology. Hair Follicle / pathology. Neoplasms, Adnexal and Skin Appendage / diagnosis. Skin / pathology. Sweat Glands / pathology
  • [MeSH-minor] Adult. Atrophy / pathology. Biopsy. Cell Proliferation. Diagnosis, Differential. Elastic Tissue / pathology. Female. Hamartoma / diagnosis. Humans. Male. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 20175822.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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52. Page RN, Dittrich L, King R, Boulos F, Page DL: Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report. J Cutan Pathol; 2009 Nov;36(11):1206-9
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  • [Title] Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report.
  • Originally described by Rosen in 1983, syringomatous nipple adenoma (SAN) is a tumor of disputed histogenesis, which can be problematic both diagnostically and therapeutically.
  • It is a benign primary tumor of breast epithelium with histology similar to that of the syringoma.
  • This case represents, to our knowledge, the first such reported case, and represents a significant finding as its presence could lend some confusion as to whether or not this represents a benign primary process of breast or a potentially infiltrative tumor of the skin.
  • [MeSH-major] Adenoma / pathology. Breast Neoplasms / pathology. Nipples / pathology. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19469876.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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53. Kakitsubata Y, Theodorou SJ, Theodorou DJ, Nakahara M, Yuki Y, Yokouchi T: Giant chondroid syringoma presenting as a growing subcutaneous mass in the upper arm: MRI findings with pathologic correlation. Joint Bone Spine; 2009 Dec;76(6):711-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondroid syringoma of skin is a rare type of soft tissue tumor originating from the sweat glands.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Magnetic Resonance Imaging / methods. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19793672.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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54. Puri PK, Galan A, Glusac EJ, Cowper SE: Metastatic cutaneous carcinoid tumor mimicking an adnexal poroid neoplasm. J Cutan Pathol; 2008 Jan;35(1):54-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Apocrine Glands / pathology. Carcinoid Tumor / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 18095995.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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55. Shah SS, Adelson M, Mazur MT: Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases. Int J Gynecol Pathol; 2008 Jul;27(3):453-6
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  • [Title] Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases.
  • Adenocarcinoma in situ rarely occurs in vulvar papillary hidradenoma.
  • We encountered 2 cases of adenocarcinoma in situ arising in a papillary hidradenoma of the vulva.
  • On microscopic examination, the tumors showed focal features of benign hidradenoma at the periphery with transitions into areas of increasing cytologic atypia that fulfilled criteria for adenocarcinoma in situ similar to that seen in the breast.
  • Both lesions show areas strongly immunoreactive for mammaglobin and gross cystic disease fluid protein 15 as well as estrogen and progesterone receptor protein in 1 case.
  • There was no evidence of benign ectopic breast tissue within or adjacent to the neoplasms.
  • The fact that these tumors displayed morphologic and immunohistochemical features that resembled ductal carcinoma in situ of the breast demonstrates the close homology between papillary hidradenoma and breast epithelium.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Carcinoma in Situ / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Disease Progression. Female. Humans

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  • (PMID = 18580327.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Soh HC, Russell P, Dalrymple C: Benign mixed tumour of the vulva. Pathology; 2005 Oct;37(5):389-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign mixed tumour of the vulva.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 16194854.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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57. Tey HL: Characterizing the nature of eccrine syringofibroadenoma: illustration with a case showing spontaneous involution. Clin Exp Dermatol; 2009 Jul;34(5):e66-8
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  • [Title] Characterizing the nature of eccrine syringofibroadenoma: illustration with a case showing spontaneous involution.
  • Eccrine syringofibroadenoma (ESFA) is a histological entity.
  • Reactive ESFA represents a hyperplastic and hamartomatous process, and may be more appropriately known as reactive eccrine syringofibroadenomatosis.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Fibroadenoma / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Eccrine Glands. Female. Humans. Leprosy, Lepromatous / complications. Neoplasm Regression, Spontaneous

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  • (PMID = 19438523.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Cashell AW: Apocrine adenoma of the breast. W V Med J; 2008 Mar-Apr;104(2):16-9
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  • [Title] Apocrine adenoma of the breast.
  • A case of apocrine adenoma, a rare benign tumor of the breast is reported.
  • Apocrine adenomas have been reported arising in a variety of sites including the breast, (1-5) perianal region, (6,7) eyelid, (8) and axilla. (9) Their appearance has similarities to the apocrine metaplasia commonly seen in fibrocystic change of the breast but they are well-circumscribed tumors with closely packed tubular and papillary structures.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Apocrine Glands / pathology. Breast Neoplasms / diagnosis

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  • (PMID = 18491794.001).
  • [ISSN] 0043-3284
  • [Journal-full-title] The West Virginia medical journal
  • [ISO-abbreviation] W V Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Rammeh-Rommani S, Achach T, Abid L, Sriha B, Denguezli M, Mokni M, Korbi S: [A nodule of the scalp]. Ann Dermatol Venereol; 2009 Jan;136(1):66-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Scalp. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 19171238.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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60. Kamakura T, Horii A, Mishiro Y, Takashima S, Kubo T: Magnetic resonance imaging of syringocystadenoma papilliferum of the external auditory canal. Auris Nasus Larynx; 2006 Mar;33(1):53-6
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  • Signal intensities on T2-weighted images of this tumor were low compared to those of pleomorphic adenoma.
  • All ceruminous gland tumors including SCAP are thought to be potentially malignant; therefore, pre-operative biopsy should not be performed.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External / pathology. Magnetic Resonance Imaging. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 16168591.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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61. Laxmisha C, Thappa DM, Mishra MM, Verma SK: Linear syringocystadenoma papilliferum of the scalp. J Eur Acad Dermatol Venereol; 2007 Feb;21(2):275-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Scalp Dermatoses / diagnosis. Syringoma / diagnosis


62. Mellanby RJ, Craig R, Evans H, Herrtage ME: Plasma concentrations of parathyroid hormone-related protein in dogs with potential disorders of calcium metabolism. Vet Rec; 2006 Dec 16;159(25):833-8
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  • The plasma concentrations of total calcium, ionised calcium, albumin, parathyroid hormone and parathyroid hormone-related protein (PTHrp) were measured in 25 dogs with lymphoma, nine dogs with primary hyperparathyroidism and seven dogs with adenocarcinoma of the apocrine gland of the anal sac.
  • The concentration of PTHrp was high in 12 of the 14 dogs that were hypercalcaemic because of an underlying malignancy but was within the reference range in all the control dogs, in the 17 normocalcaemic dogs with lymphoma and in the seven dogs which were hypercalcaemic because of a parathyroid adenoma.
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / veterinary. Anal Sacs. Animals. Case-Control Studies. Dogs. Hyperparathyroidism / diagnosis. Hyperparathyroidism / veterinary. Lymphoma / diagnosis. Lymphoma / veterinary. Predictive Value of Tests. Sensitivity and Specificity. Sweat Gland Neoplasms / diagnosis. Sweat Gland Neoplasms / veterinary

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  • (PMID = 17172477.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein
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63. Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A: Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature. Int J Dermatol; 2006 Oct;45(10):1218-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17040446.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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64. Ko JY, Lee CW, Moon SH, Song KW, Park CK: Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. J Korean Med Sci; 2006 Feb;21(1):172-6
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  • [Title] Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study.
  • We report a rare case of giant vascular eccrine spiradenoma (GVES) which developed in 56-yr-old Korean woman.
  • It is a rare variant of eccrine spiradenoma (ES), which might be mistaken for angiomatous lesions in view of its florid vascularity and hemorrhagic features.
  • Histogenesis of GVES is not clearly elucidated although it is known that ES presumably originates in the eccrine glands.
  • Therefore, we conclude that GVES originated from eccrine gland and mainly differentiates toward secretory portion of secretory coil.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Eccrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • [Cites] J Cutan Pathol. 1992 Aug;19(4):294-301 [1331211.001]
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  • (PMID = 16479087.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers; 0 / CAM 5.2 antigen; 0 / CKAP4 protein, human; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Membrane Proteins; 0 / Mucin-1; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2733970
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65. Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G: Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. Genes Chromosomes Cancer; 2005 Jun;43(2):202-5
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  • [Title] Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
  • Recent studies have shown that the t(11;19)(q21;p13) translocation in mucoepidermoid carcinomas and benign Warthin's tumors results in a fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a.
  • Here we show that a third tumor type, clear cell hidradenoma of the skin, also expresses this gene fusion.
  • RT-PCR analysis of a clear cell hidradenoma with a t(11;19)(q21;p13) translocation revealed expression of a TORC1-MAML2 fusion transcript consisting of exon 1 of TORC1 fused to exons 2-5 of MAML2.
  • These results demonstrate that the t(11;19) in mucoepidermoid carcinoma, Warthin's tumor, and clear cell hidradenoma targets the same genes and results in identical gene fusions, indicating that at least subgroups of these glandular tumors evolve through activation of the same molecular pathways.
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Nuclear Proteins / genetics. Skin Neoplasms / genetics. Transcription Factors / genetics. Translocation, Genetic

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15729701.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Transcription Factors
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66. Monteagudo B, Iglesias B, de la Torre C, Paredes C, Vázquez-Blanco M, Ginarte M, Labandeira J: [Poroid hidradenoma]. Actas Dermosifiliogr; 2005 Jul-Aug;96(6):398-9
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  • [Title] [Poroid hidradenoma].
  • Poroid hidradenoma is a recently described variant of eccrine poroma.
  • This neoplasm presents structural findings of hidradenoma (solid and cystic areas) and cytological characteristics of poromas (poroid and cuticular cells, the latter showing ductal differentiation).
  • We present a case of poroid hidradenoma in a 74-year-old woman, who consulted her physician because of a nodular lesion on the left buttock.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476263.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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67. Gönül M, Soylu S, Gül U, Kaya I, Albayrak L, Unal T: Linear syringocystadenoma papilliferum of the arm: a rare localization of an uncommon tumour. Acta Derm Venereol; 2008;88(5):528-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18779904.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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68. Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R: Syringocystadenoma papilliferum: report of 8 cases. Pathologica; 2006 Jun;98(3):178-80
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  • It arises in about one third of cases within a sebaceous hamartoma (SH) and in this case, multiple other benign adnexal neoplasms may be associated with it.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17036946.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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69. Ozawa T, Fujiwara M, Nose K, Muraoka M: Clear-cell hidradenoma of the forearm in a young boy. Pediatr Dermatol; 2005 Sep-Oct;22(5):450-2
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  • [Title] Clear-cell hidradenoma of the forearm in a young boy.
  • We treated a 5-year-old boy with clear-cell hidradenoma of the forearm.
  • Our literature search found only one previous report of this disease occurring during the first decade of life, and the present patient is the first with involvement of the limbs.
  • This presentation demonstrates that clear-cell hidradenoma needs to be considered in the differential diagnosis of cutaneous tumors even in young children, which is of interest because malignant transformation can occur.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16191000.001).
  • [ISSN] 0736-8046
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Monteagudo B, Antón-Badiola IM, Muñoz MJ, Paredes-Suárez C, Vázquez-Blanco M: [Pigmented apocrine hidradenoma]. Actas Dermosifiliogr; 2005 Jan-Feb;96(1):50-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pigmented apocrine hidradenoma].
  • Apocrine hidradenoma is a benign adnexal neoplasm.
  • The same as other tumors of the sweat glands, there is a pigmented variety.
  • After the histopathological study, the diagnosis was established as pigmented apocrine hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Hyperpigmentation / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 16476334.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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71. Martinelli PT, Cohen PR, Schulze KE, Tschen JA, Nelson BR: Mohs micrographic surgery for tubular apocrine adenoma. Int J Dermatol; 2006 Nov;45(11):1377-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mohs micrographic surgery for tubular apocrine adenoma.
  • [MeSH-major] Adenoma, Sweat Gland / surgery. Apocrine Glands / surgery. Mohs Surgery. Sweat Gland Neoplasms / surgery

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  • (PMID = 17076735.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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72. Goodden JR, Marven SS, Cohen M, de Ville McMullan PJ, Smith MF: Congenital apocrine tumour: a rare scalp tumour. Eur J Pediatr Surg; 2008 Aug;18(4):282-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a rare congenital scalp tumour with histological diagnosis of a congenital apocrine adenoma with features of a tubular adenoma.
  • [MeSH-major] Apocrine Glands. Head and Neck Neoplasms / congenital. Scalp. Skin Neoplasms / congenital. Sweat Gland Neoplasms / congenital

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  • (PMID = 18629773.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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73. Angulo J, Jaqueti G, Kutzner H, Requena L: Squamous cell apocrine hidradenoma. J Cutan Pathol; 2007 Oct;34(10):801-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell apocrine hidradenoma.
  • Apocrine hidradenoma is a benign adnexal neoplasm with apocrine differentiation.
  • We report two cases of apocrine hidradenoma mostly composed of squamous cells.
  • The rare cases described in this report are exceptional because most of the neoplastic cells showed squamous appearance and for that reason we think that squamous cell apocrine hidradenoma is the most appropriate name for these neoplasms.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Squamous Cell / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17880588.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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74. van Hout NM, Hazebroek EJ, de Rooij PD: A giant atypical hidradenoma on the neck. Dermatol Surg; 2008 Oct;34(10):1411-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A giant atypical hidradenoma on the neck.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Humans. Neck. Skin Transplantation

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  • (PMID = 18637811.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Kazakov DV, Mukensnabl P, Michal M: Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol; 2006 Apr;28(2):142-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
  • The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues.
  • We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation.
  • The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia.
  • In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation.
  • Rare cases occurring in the sites normally devoid of apocrine glands may represent the eccrine counterpart.
  • [MeSH-major] Adenoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Back. Cell Differentiation. Cell Lineage. Eosinophils / pathology. Epithelial Cells / pathology. Epithelium / pathology. Female. Fibroblasts / pathology. Follow-Up Studies. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Humans. Middle Aged. Scalp / pathology. Sebaceous Glands / pathology

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  • (PMID = 16625077.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Teschner M, Buhr T, Donnerstag F, Lenarz T, Majdani O: [Expansion of an ceruminous adenoma into the middle ear]. Laryngorhinootologie; 2006 Jun;85(6):444-7
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  • [Title] [Expansion of an ceruminous adenoma into the middle ear].
  • Pathohistology revealed a ceruminal gland adenoma.
  • They are a rare phenomenon and should be distinguished from middle ear adenomas, pleomorph ceruminal gland adenomas, ceruminal gland adenocarcinomas and cylindromas of the ceruminal glands.
  • Despite its rare occurrence, a ceruminal gland adenoma must be taken into consideration in the differential diagnosis of individual cholesteatoma cases.
  • [MeSH-major] Adenoma / diagnosis. Apocrine Glands / pathology. Carcinoma, Squamous Cell / diagnosis. Cerumen. Ear Canal / pathology. Ear Neoplasms / diagnosis. Ear, Middle / pathology. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16770841.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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77. Tolland JP, Brenn T, Guldbakke KK, Schanbacher CF: Mohs micrographic surgery, sentinel lymph node mapping, and estrogen receptor analysis for the treatment of malignant nodular hidradenoma. Dermatol Surg; 2006 Oct;32(10):1294-301
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  • [Title] Mohs micrographic surgery, sentinel lymph node mapping, and estrogen receptor analysis for the treatment of malignant nodular hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland. Mohs Surgery / methods. Receptors, Estrogen / metabolism. Sweat Gland Neoplasms

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  • (PMID = 17034384.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen
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78. Chiu HH, Chen PH, Wu CS, Chen GS, Tsai KB, Wen CH, Lan CC: Origin of poroid hidradenoma and pigmentation mechanism of eccrine poroma: critical analysis of an unique presentation. J Eur Acad Dermatol Venereol; 2009 May;23(5):597-9
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  • [Title] Origin of poroid hidradenoma and pigmentation mechanism of eccrine poroma: critical analysis of an unique presentation.
  • [MeSH-major] Adenoma, Sweat Gland / etiology. Eccrine Glands / pathology. Skin Pigmentation

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  • (PMID = 18783473.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Endothelin-1
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79. MacNeill KN, Riddell RH, Ghazarian D: Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature. J Clin Pathol; 2005 Feb;58(2):217-9
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  • [Title] Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature.
  • Benign apocrine lesions have been described in the anogenital region, although according to the World Health Organisation convincing examples of anal apocrine adenocarcinomas have not been published.
  • This report describes the case of an invasive apocrine adenocarcinoma arising in a benign adenoma in the perianal region of a 45 year old woman.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Sweat Gland / pathology. Anus Neoplasms / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology


80. Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M: Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. Am J Dermatopathol; 2010 May;32(3):215-21
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  • We performed immunohistochemical assessment of p53 expression and TP53 mutational analysis of 15 malignant neoplasms arising from preexisting benign cylindroma, spiradenoma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
  • None of the 12 benign control group cases harbored a TP53 mutation, whereas all 12 demonstrated single nucleotide polymorphisms identical to those detected in the malignant tumor group.
  • In conclusion, we found a fairly high rate of p53 expression in malignant neoplasms arising from preexisting benign spiradenomas, cylindromas, and spiradenocylindromas.
  • Whereas immunostaining for p53 has been suggested as an adjunct tool to differentiate benign spiradenoma, cylindroma, and spiradenocylindroma from their malignant counterparts, its utility is limited by its heterogeneous pattern of expression, especially the sometimes lack of staining in clearly malignant areas and the occurrence of focal, weak positivity in the benign residua or in unequivocally benign neoplasms.
  • [MeSH-major] Adenoma / genetics. Carcinoma, Adenoid Cystic / genetics. Neoplasms, Multiple Primary / genetics. Point Mutation. Sweat Gland Neoplasms / genetics. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 20075707.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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81. Kazakov DV, Bisceglia M, Calonje E, Hantschke M, Kutzner H, Mentzel T, Michal M, Mukensnabl P, Spagnolo DV, Rütten A, Rose C, Urso C, Vazmitel M, Zelger B: Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists. Am J Dermatopathol; 2007 Jun;29(3):256-63
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  • [Title] Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists.
  • Tubular adenoma (TA) and syringocystadenoma papilliferum (SCAP) may show histopathological overlap, with some lesions having features of both neoplasms (SCAP + TA).
  • Four observers blindly assessed 67 cases of TA, SCAP, and their lookalikes (poroma, apocrine adenoma, apocrine carcinoma; all lesions focally featuring a pseudopapillary pattern), and classified the lesions into one of four categories:.
  • Lesions were also classified as benign or malignant.
  • All observers agreed that the lesions were benign; the only apocrine carcinoma included was recognized as such by all observers.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Cystadenoma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17519623.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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82. Biedrzycki OJ, Rufford B, Wilcox M, Barton DP, Jameson C: Malignant clear cell hidradenoma of the vulva: report of a unique case and review of the literature. Int J Gynecol Pathol; 2008 Jan;27(1):142-6
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  • [Title] Malignant clear cell hidradenoma of the vulva: report of a unique case and review of the literature.
  • Clear cell hidradenoma (CCH) is a rare tumor derived from eccrine sweat glands with a predilection for the head, face, and upper extremities.
  • A previously healthy 39-year-old woman underwent marsupialization of a presumed left-side vulval Bartholin gland cyst.
  • It also highlights the importance of considering MCCH in the differential diagnosis of a lymph node containing a metastatic clear cell tumor or an apparent metastatic clear cell lesion in the skin.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 18156989.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Lee CK, Jang KT, Cho YS: Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. J Laryngol Otol; 2005 Dec;119(12):1004-6
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  • [Title] Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal.
  • Tubular apocrine adenoma (TAA) is a very rare sweat gland tumour.
  • [MeSH-major] Adenoma / pathology. Ear Canal / pathology. Ear Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16354370.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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84. Yosepovich A, Perelman M, Ayalon S, Papa M, Kopolovic J: Syringomatous adenoma of the nipple: a case report. Pathol Res Pract; 2005;201(5):405-7
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  • [Title] Syringomatous adenoma of the nipple: a case report.
  • Histological examination revealed the morphologic and immunohistochemical pattern of syringomatous adenoma of the nipple.
  • This is a rare lesion of the breast that can clinically mimic breast carcinoma, but harbors a benign and only locally aggressive course.
  • [MeSH-major] Breast Neoplasms / pathology. Nipples. Sweat Gland Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 16047951.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Actins
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85. Seyhan T, Borman H, Bal N: Malignant eccrine spiradenoma of the scalp. J Craniofac Surg; 2008 Nov;19(6):1608-12
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  • [Title] Malignant eccrine spiradenoma of the scalp.
  • Malignant eccrine spiradenoma is a rare neoplasm generally arising from long-standing benign eccrine spiradenomas; it is rarely seen on the scalp.
  • A 27-year-old woman with a malignant eccrine spiradenoma of the scalp, which had occurred 8 months after the inadequate excision of a benign eccrine spiradenoma, was treated at our hospital.
  • A split-thickness skin graft was applied on the exposed inner table.
  • We report a case of a malignant eccrine spiradenoma of the scalp with cranial involvement that arose from an inadequately removed, long-standing, benign eccrine spiradenoma in a young patient.
  • Also, we review the existing literature on malignant eccrine spiradenoma of the scalp.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Scalp / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Alopecia / diagnosis. Female. Follow-Up Studies. Humans. Neoplasm Invasiveness. Sentinel Lymph Node Biopsy. Skin Transplantation


86. Ogawa R, Akaishi S, Hyakusoku H: Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg; 2009 Jun;62(6):660-4
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  • All tumors were benign: apocrine cystadenoma, adult-onset juvenile xanthogranuloma, mixed tumor, and chronic folliculitis.
  • (1) biopsy should be conducted in anomalous cases because malignant disease may be the original or secondary problem, (2) steroid injection should be performed only after careful consideration because malignancy or infections may be present, (3) careful differential diagnosis is particularly challenging in African-Americans because skin and tumor color are often similar, and (4) the presence of bacterial or fungal infection should be investigated.
  • [MeSH-major] Cicatrix, Hypertrophic / diagnosis. Keloid / diagnosis. Skin Diseases / diagnosis
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adult. Cystadenoma / pathology. Diagnosis, Differential. Folliculitis / pathology. Humans. Male. Middle Aged. Sweat Gland Neoplasms / pathology. Xanthogranuloma, Juvenile / pathology. Young Adult

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  • (PMID = 19461281.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Tanahashi J, Kashima K, Daa T, Kondoh Y, Yada N, Kuratomi E, Yokoyama S: A case of sebaceoma with extensive apocrine differentiation. Am J Dermatopathol; 2008 Aug;30(4):408-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Apocrine Glands / pathology. Sweat Gland Neoplasms / pathology

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  • [CommentIn] Am J Dermatopathol. 2009 Feb;31(1):94 [19155736.001]
  • (PMID = 18645320.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Lee JS, Chang KC, Chen HH, Sze CI: Malignant sweat gland tumor presenting as an unusual dural-based lesion: case report. J Neurooncol; 2010 Sep;99(2):273-6
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  • [Title] Malignant sweat gland tumor presenting as an unusual dural-based lesion: case report.
  • Malignant sweat gland tumors are rare neoplasms with high recurrence and metastasis rates of over 50%.
  • Given the lack of scalp or skull bone involvement, we speculated that the tumor may have arisen from ectopic sweat gland cells entrapped in the dural mater.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Brain Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 20069341.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Turhan-Haktanir N, Demir Y, Tokyol C: A case of eccrine spiradenoma arising in nevus sebaceous in an adolescent girl. Am J Dermatopathol; 2008 Apr;30(2):196-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of eccrine spiradenoma arising in nevus sebaceous in an adolescent girl.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Cell Transformation, Neoplastic / pathology. Skin Neoplasms / pathology

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  • (PMID = 18360132.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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90. Yu G, Goodloe S Jr, D'Angelis CA, McGrath BE, Chen F: Giant clear cell hidradenoma of the knee. J Cutan Pathol; 2010 Sep;37(9):e37-41
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  • [Title] Giant clear cell hidradenoma of the knee.
  • Hidradenomas, also referred to as nodular hidradenomas or clear cell hidradenomas (CCH), are benign cutaneous eccrine tumors usually 2-3 cm in dimension.
  • We report a case of an 8.0 x 6.0 x 3.0 cm clear cell hidradenoma of the left knee in a 43-year-old man.
  • Grossly, the resected tumor was unencapsulated and tan, with a solid and cystic cut surface showing papillary excrescences on the cyst wall.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19615032.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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91. Jukic DM, Drogowski LM, Davie JR: Carcinoma ex spiradenoma/cylindroma confirmed by immunohistochemical and molecular loss-of-heterozygosity profiling. Am J Dermatopathol; 2009 Oct;31(7):702-8
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  • For 9 years, the patient remained disease free until complaining of a slow-growing skin nodule on the lower back that was excised under clinical suspicion of metastatic mammary carcinoma.
  • Histopathological exam revealed a benign eccrine spiradenoma/cylindroma and an intermixed carcinoma, with a differential diagnosis of either primary eccrine carcinoma or mammary carcinoma metastatic to the spiradenoma/cylindroma.
  • Histological features and immunohistochemical staining favored eccrine carcinoma but not unequivocally; therefore, LOH profiles were performed on archival paraffin block tissue from the 3 neoplastic lesions (4 components).
  • Both the spiradenoma/cylindroma and eccrine carcinoma revealed no LOH at the tested loci, establishing the unknown carcinoma as an independent carcinoma arising within a spiradenoma/cylindroma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19684510.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Lin D, Perri AJ 3rd, Weaver JM, Colome MI, Raimer SS: What is your diagnosis? Benign acrospiroma. Cutis; 2009 Jan;83(1):12, 21-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] What is your diagnosis? Benign acrospiroma.
  • [MeSH-major] Acrospiroma / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 19271564.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Minami S, Sadanobu N, Ito T, Natsuaki M, Yamanishi K: Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases. J Dermatol; 2006 Apr;33(4):256-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases.
  • Hidradenoma papilliferum is a benign tumor that usually occurs in the female anogenital region.
  • We present a 52-year-old male with a non-anogenital (ectopic) hidradenoma papilliferum on his face.
  • The lesion contained sebaceous differentiation, which has not been previously documented in the histopathology of hidradenoma papilliferum.
  • We review the published work of non-anogenital (ectopic) hidradenoma papilliferum tumors on the head and neck.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Facial Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16674789.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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94. Jouary T, Kaiafa A, Lipinski P, Vergier B, Lepreux S, Delaunay M, Taïeb A: Metastatic hidradenocarcinoma: efficacy of capecitabine. Arch Dermatol; 2006 Oct;142(10):1366-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Antimetabolites, Antineoplastic / therapeutic use. Deoxycytidine / analogs & derivatives. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 17043204.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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95. Carlsten JR, Lewis MD, Saddler K, Reilly P, Pan T, Gnepp DR, Robinson-Bostom L: Spiradenocylindrocarcinoma: a malignant hybrid tumor. J Cutan Pathol; 2005 Feb;32(2):166-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Eccrine spiradenomas and cylindromas are benign, slowly growing, cutaneous adnexal neoplasms, recently hypothesized to arise from a common pluripotential cell; malignant variants are rare.
  • Benign tumors demonstrating both spiradenomatous and cylindromatous features have been infrequently reported.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Carcinoma, Adenoid Cystic / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • [ErratumIn] J Cutan Pathol. 2005 Jul;32(6):453
  • (PMID = 15606677.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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96. Kazakov DV, Requena L, Kutzner H, Fernandez-Figueras MT, Kacerovska D, Mentzel T, Schwabbauer P, Michal M: Morphologic diversity of syringocystadenocarcinoma papilliferum based on a clinicopathologic study of 6 cases and review of the literature. Am J Dermatopathol; 2010 Jun;32(4):340-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphologic diversity of syringocystadenocarcinoma papilliferum based on a clinicopathologic study of 6 cases and review of the literature.
  • The purpose of our investigation was to study a series of syringocystadenocarcinoma papilliferum to document morphologic variations of the neoplasm.
  • It is concluded that morphologic diversity of syringocystadenocarcinoma papilliferum is substantial.
  • Its association with the benign counterpart and ductal changes suggests a transformation that may involve usual ductal hyperplasia-atypical ductal hyperplasia-(ductal) adenocarcinoma in situ-invasive adenocarcinoma pathway.
  • [MeSH-major] Cystadenocarcinoma, Papillary / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Carcinoma, Ductal / pathology. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged

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  • (PMID = 20216201.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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97. Gonul M, Cakmak SK, Gul U, Han O, Karagece U: A skin tumor in a young girl. Diagnosis: Clear cell hidradenoma. Indian J Dermatol Venereol Leprol; 2010 Jul-Aug;76(4):445-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A skin tumor in a young girl. Diagnosis: Clear cell hidradenoma.
  • [MeSH-major] Acrospiroma / pathology. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 20657141.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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98. Veeranna S: Linear plaque over the face. Indian J Dermatol Venereol Leprol; 2006 Jan-Feb;72(1):83-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Facial Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16481726.001).
  • [ISSN] 0378-6323
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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99. Sington J, Chandrapala R, Manek S, Hollowood K: Mitotic count is not predictive of clinical behavior in hidradenoma papilliferum of the vulva: a clinicopathologic study of 19 cases. Am J Dermatopathol; 2006 Aug;28(4):322-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mitotic count is not predictive of clinical behavior in hidradenoma papilliferum of the vulva: a clinicopathologic study of 19 cases.
  • Although it is generally recognized that some benign sweat gland neoplasms may show appreciable mitotic activity, there are few reports of its quantitative analysis in specific tumor types or of its correlation with clinical behavior.
  • The presence of a large number of mitoses in a sweat gland tumor for which the histologic criteria of malignancy are not well defined, particularly in association with nuclear abnormalities, may produce a considerable diagnostic challenge.
  • We recently encountered such a problem in a putative case of hidradenoma papilliferum.
  • Therefore, we have undertaken a retrospective clinicopathologic study of 19 cases originally diagnosed as hidradenoma papilliferum or probable hidradenoma papilliferum, with a particular emphasis on the relationship of the mitotic index to clinical behavior.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Mitosis. Vulvar Diseases / pathology

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  • (PMID = 16871035.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • The commonest variants are those of eccrine sweat gland origin.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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