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1. Park SY, Kim HS, Yoon KW, Cho SB, Lee WS, Park CH, Joo YE, Choi SK, Rew JS: [Prevalence of colorectal adenoma is increased in patients with gastric adenoma]. Korean J Gastroenterol; 2009 Oct;54(4):220-6
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  • [Title] [Prevalence of colorectal adenoma is increased in patients with gastric adenoma].
  • BACKGROUND/AIMS: It has been reported that patients with gastric cancer may be at increased risk of synchronous or metachronous colorectal cancer.
  • However, the incidence of colorectal adenoma in patients with gastric adenoma has not been discussed earlier.
  • The aims of this study were to investigate the incidence of colorectal adenoma and to evaluate the necessity of colonoscopic surveillance in patients with gastric adenoma.
  • METHODS: We performed colonoscopy in 221 patients with gastric adenoma between January 2002 and June 2008.
  • As a control group, 387 consecutive patients without gastric adenoma on gastroscopy who underwent colonoscopy were included.
  • RESULTS: Colorectal adenoma were diagnosed in 57.5% (127/221) of the gastric adenoma group and 38.0% (147/387) of the control group (p<0.001).
  • Univariate analysis demonstrated that gender, age, past history of diabetes, and past history of gastric adenoma were associated with the risk of colorectal adenoma.
  • Multivariate analysis demonstrated that gender (male, aOR 2.31, 95% CI 1.61-3.31), age (> or =50 years, aOR 2.47, 95% CI 1.53-4.01), past history of diabetes (aOR 2.35, 95% CI 1.32-4.20), and presence of gastric adenoma (aOR 1.63, 95% CI 1.13-2.36) appeared to be independent risk factors for colorectal adenoma.
  • CONCLUSIONS: The risk of colorectal adenoma increases significantly in patients with gastric adenoma.
  • We suggest that colonoscopic surveillance may be necessary in patients with gastric adenoma.
  • [MeSH-major] Adenoma / diagnosis. Colorectal Neoplasms / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Age Factors. Aged. Colonoscopy. Diabetes Mellitus / diagnosis. Female. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Risk Factors. Sex Factors

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  • (PMID = 19844141.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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2. Jang JS, Choi SR, Han SY, Roh MH, Lee JH, Lee SW, Jeung JS, Kim MC, Son YK, Baek YH: [Predictive significance of serum IL-6, VEGF, and CRP in gastric adenoma and mucosal carcinoma before endoscopic submucosal dissection]. Korean J Gastroenterol; 2009 Aug;54(2):99-107
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  • [Title] [Predictive significance of serum IL-6, VEGF, and CRP in gastric adenoma and mucosal carcinoma before endoscopic submucosal dissection].
  • BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) is commonly used for radical resection of gastric adenoma and mucosal cancer, but there is about 30% of discrepancy rate between the histology of the endoscopic biopsy and that of the resected specimen obtained from the same lesion by ESD.
  • METHODS: We investigated the correlation between serum IL-6, VEGF, CRP level and discrepancy rate of gastric neoplastic lesions (10 low-grade dysplasias, 18 high-grade dysplasias, and 25 early gastic cancers).
  • RESULTS: Serum levels of IL-6 in gastric adenoma and mucosal cancer patients were significantly higher than in healthy controls (p<0.05).
  • Serum levels of VEGF in patients with gastric adenoma and mucosal cancer were significantly higher than healthy controls (p<0.01).
  • CONCLUSIONS: Serum levels of IL-6, VEGF, and CRP in patients with gastric neoplastic lesions were significantly higher than healthy controls, especially, serum IL-6 level of high grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients.
  • [MeSH-major] Adenoma / diagnosis. C-Reactive Protein / analysis. Carcinoma / diagnosis. Gastric Mucosa / surgery. Interleukin-6 / blood. Stomach Neoplasms / diagnosis. Vascular Endothelial Growth Factors / blood
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Gastroscopy. Humans. Male. Middle Aged. Predictive Value of Tests

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  • (PMID = 19696537.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Interleukin-6; 0 / Vascular Endothelial Growth Factors; 9007-41-4 / C-Reactive Protein
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3. Kang HJ, Park DY, Kim KH, Song GA, Lauwers GY: [Pathologic diagnosis of gastric epithelial neoplasia]. Korean J Gastroenterol; 2008 Nov;52(5):273-80
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  • [Title] [Pathologic diagnosis of gastric epithelial neoplasia].
  • Gastric epithelial neoplasia is a very common disease entity in Korea, encompassing gastric adenoma and adenocarcinoma.
  • There are still discrepancies in pathologic diagnosis of gastric epithelial neoplasia between Western and Japanese pathologists after Vienna consensus classification.
  • With increasing use of endoscopic therapy such as endoscopic mucosal resection and endoscopic submucosal dissection, it is very important to agree on the consensus criteria in the diagnosis of gastric epithelial neoplasia among pathologists in Korea.
  • On this background, the current concepts, and contemporary issues of definition, diagnostic and classification criteria of gastric epithelial neoplasia were reviewed.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Stomach Neoplasms / pathology. Terminology as Topic

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  • (PMID = 19077472.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Korea (South)
  • [Number-of-references] 25
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4. Kimura M, Irie A, Minei S, Ishii J, Okawa A, Takashima R, Kadowaki K, Morinaga S, Baba S: [A case of adrenocortical adenoma coexisting with gastrointestinal stromal tumor]. Hinyokika Kiyo; 2007 Aug;53(8):551-5
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  • [Title] [A case of adrenocortical adenoma coexisting with gastrointestinal stromal tumor].
  • A 48-year-old man was referred to our institute for the evaluation of a concomitant gastric submucosal tumor and right adrenal tumor, incidentally found by ultrasound examination.
  • Computed tomography showed a mass with a diameter of 6 cm adjacent to the stomach and the right adrenal tumor with a diameter of 3 cm.
  • On the other hand, the gastric submucosal tumor showed low intensity in T1 weighted images and high intensity in T2 weighted images.
  • Pathological diagnosis of the adrenal tumor was a cortical adenoma, and that of the gastric submucosal tumor was gastrointestinal stromal tumor (GIST).
  • The gastric tumor was immunohistochemically stained positive with the C-kit and CD34 and negative for s-100 protein and desmin.
  • Histopathological diagnosis was coincident with gastric GIST and right adrenocortical adenoma, and the GIST was diagnosed as a high risk tumor because its diameter was over 5 cm.
  • [MeSH-major] Adrenal Cortex Neoplasms / surgery. Adrenocortical Adenoma / surgery. Gastrointestinal Stromal Tumors / surgery. Laparoscopy. Stomach Neoplasms / surgery

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  • (PMID = 17874546.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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5. Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T: Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach. Gastric Cancer; 2006;9(3):177-84
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  • [Title] Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.
  • Since 1985, when gastric-type well-differentiated adenocarcinomas were demonstrated in hyperplastic polyps of the stomach, we have studied phenotypic expression in gastrointestinal epithelial lesions.
  • The disease entity of gastric-type well-differentiated adenocarcinoma has recently been accepted, especially in Japan and Europe.
  • Even under these circumstances, the term "gastric adenoma" usually means flat adenoma of the intestinal type.
  • Gastric-type adenomas have been regarded as exceptional until recently.
  • Although gastric-type adenomas could theoretically be classified into foveolar type and pyloric-gland type, foveolar-type adenoma is, in practice, difficult to distinguish from gastric-foveolar-type adenocarcinoma.
  • In 2003, we first reported systematic clinicopathological analyses of pyloric gland adenoma, demonstrating its unstable and precancerous nature.
  • In this article, we review and discuss the clinicopathological and molecular pathological aspects of gastric-type well-differentiated adenocarcinomas and pyloric gland adenomas, mainly based on our published and unpublished data.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Gastric Mucosa / pathology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Chromosome Aberrations. Humans. Molecular Diagnostic Techniques. Nucleic Acid Hybridization / methods. Stomach / cytology. Stomach / pathology

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  • (PMID = 16952035.001).
  • [ISSN] 1436-3291
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 42
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6. Kushima R, Vieth M: [Tubular adenoma of the stomach with special reference to the Japanese criteria and pyloric gland adenoma]. Pathologe; 2010 May;31(3):177-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tubular adenoma of the stomach with special reference to the Japanese criteria and pyloric gland adenoma].
  • [Transliterated title] Das tubuläre Magenadenom. Mit Darstellung der Japanischen Kriterien unter Berücksichtigung des "pyloric gland adenoma"
  • The term gastric adenoma usually refers to a flat adenoma of the intestinal type.
  • Adenomas of the gastric type, so-called pyloric gland adenomas (PGA), which was first characterized by German and Japanese pathologists in 1990, have been regarded as exceptional until recently.
  • In this article we introduce the Japanese criteria of the gastric adenoma and review and discuss the clinical pathological and molecular aspects of PGAs.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Intestinal Neoplasms / genetics. Intestinal Neoplasms / pathology. Stomach Neoplasms / genetics. Stomach Neoplasms / pathology

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  • [Cites] Mod Pathol. 2003 Aug;16(8):786-95 [12920223.001]
  • [Cites] Int J Cancer. 2001 Oct 15;94(2):166-70 [11668493.001]
  • [Cites] Gut. 2000 Aug;47(2):251-5 [10896917.001]
  • [Cites] Virchows Arch. 2005 May;446(5):542-5 [15838648.001]
  • [Cites] Virchows Arch. 2003 Apr;442(4):317-21 [12715167.001]
  • [Cites] Virchows Arch. 2002 Feb;440(2):205-8 [11964052.001]
  • [Cites] Virchows Arch. 2005 May;446(5):537-41 [15838649.001]
  • [Cites] Virchows Arch. 1999 Oct;435(4):452-7 [10526011.001]
  • [Cites] Am J Surg Pathol. 2002 Oct;26(10):1276-85 [12360042.001]
  • [Cites] Pathol Int. 1996 Nov;46(11):908-17 [8970203.001]
  • [Cites] Pathol Res Pract. 1996 Sep;192(9):963-9; discussion 970-1 [8950764.001]
  • [Cites] Gastric Cancer. 2006;9(3):177-84 [16952035.001]
  • (PMID = 20349063.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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7. Tamai N, Kaise M, Nakayoshi T, Katoh M, Sumiyama K, Gohda K, Yamasaki T, Arakawa H, Tajiri H: Clinical and endoscopic characterization of depressed gastric adenoma. Endoscopy; 2006 Apr;38(4):391-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and endoscopic characterization of depressed gastric adenoma.
  • BACKGROUND AND STUDY AIM: Depressed gastric adenoma remains poorly characterized because it is rare, and is infrequently detected by endoscopy.
  • The aim of this study was to elucidate clinical and endoscopic characteristics of depressed adenoma of the stomach.
  • PATIENTS AND METHODS: 95 consecutive patients who underwent endoscopic resection of gastric adenomas were studied.
  • Gastric adenomas, diagnosed according to the Vienna classification, were endoscopically classified into two types: depressed and protruding adenomas.
  • In order to clarify endoscopic features of gastric adenomas, we performed indigo carmine chromoendoscopy as well as magnifying endoscopy with narrow band imaging, which yields clear images of mucosal microvasculature.
  • RESULTS: 12% of 100 gastric adenomas resected from 95 patients were depressed adenomas.
  • [MeSH-major] Adenoma / pathology. Endoscopy, Gastrointestinal / methods. Gastric Mucosa / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16680640.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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8. Kim BS, Joo SH, Joo KR: Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report. World J Gastroenterol; 2008 Aug 7;14(29):4705-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report.
  • We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice.
  • The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct.
  • At follow-up 8 mo later, endoscopy showed multiple polyps in the rectum, colon and stomach.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 18698689.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738799
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9. Chang HJ, Oh SN, Park MY, Rha SE, Choi BG: Fraudulent retouching of digital radiographic images--a potential risk. Clin Radiol; 2010 Dec;65(12):967-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: Ten representative key images were selected of aortic dissection, hepatocellular carcinoma, renal cell carcinoma, colon cancer, liver metastasis, hepatic cyst, gallbladder stones, splenic artery aneurysm, adrenal adenoma, and stomach cancer from abdominal computed tomography (CT) imaging performed in 2008.
  • Radiologists were requested to make a diagnosis for the 10 images, and were then asked to identify possible retouched images.
  • None of the reviewers recognized that some images were retouched during diagnosis.
  • The rate of correct diagnosis was 90% (range 71.7-100%).
  • The time to diagnosis and the time to detection of the retouched images were 15 (14-17) and 6 (5-7) min, respectively.

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  • [Copyright] Copyright © 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 21070899.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Yang MH, Son HJ, Lee JH, Kim MH, Kim JY, Kim YH, Chang DK, Rhee PL, Kim JJ, Rhee JC: Do we need colonoscopy in patients with gastric adenomas? The risk of colorectal adenoma in patients with gastric adenomas. Gastrointest Endosc; 2010 Apr;71(4):774-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do we need colonoscopy in patients with gastric adenomas? The risk of colorectal adenoma in patients with gastric adenomas.
  • BACKGROUND: Gastric polyps are found frequently in various colonic polyposis syndromes.
  • Genetic alterations of several genes occur in gastric adenomas and colorectal adenomas.
  • However, it is unknown whether patients with gastric adenomas are at higher risk for colorectal adenomas.
  • OBJECTIVE: To investigate the prevalence rate of colorectal adenoma in patients with gastric adenomas and to determine the association between the presence of gastric adenomas and synchronous colorectal adenomas.
  • PATIENTS: This study involved 87 patients with gastric adenomas and 174 sex-matched and age-matched controls among 19,019 participants who underwent EGD and colonoscopy simultaneously or within 6 months of each other from January 2001 to December 2008 at the Center for Health Promotion of Samsung Medical Center.
  • MAIN OUTCOME MEASUREMENTS: The prevalence rate of colorectal adenoma in patients with gastric adenomas.
  • RESULTS: The 87 gastric adenoma patients included 72 men and 15 women.
  • The prevalence of colorectal adenoma was significantly higher in the gastric adenoma group than in the control group.
  • The majority of colorectal adenomas were located in distal colonic segments in the gastric adenoma group in contrast with proximal colonic segments in the control group.
  • Multivariate logistic regression analysis revealed that independent risk factors for colorectal adenoma were the presence of gastric adenomas (odds ratio [OR], .915; 95% confidence interval [CI], 1.044-3.513) and increasing age over 55 years (OR, 2.943; 95% CI, 1.558-5.560).
  • CONCLUSION: The risk of colorectal adenoma increases significantly in patients with gastric adenomas and in patients over age 55.
  • A screening colonoscopy may be necessary for patients with gastric adenomas to detect colorectal adenomas.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Gastroscopy. Neoplasms, Multiple Primary / diagnosis. Stomach Neoplasms / diagnosis

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20363417.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Tanaka K, Toyoda H, Kadowaki S, Kosaka R, Shiraishi T, Imoto I, Shiku H, Adachi Y: Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy. J Gastroenterol; 2006 Apr;41(4):332-8
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  • [Title] Features of early gastric cancer and gastric adenoma by enhanced-magnification endoscopy.
  • BACKGROUND: Changes to the mucosal surface of early gastric carcinomas and gastric adenomas as viewed by enhanced-magnification endoscopy with acetic acid have not been investigated thoroughly.
  • Using this technology, we investigated the appearance of the gastric surface patterns of neoplastic and surrounding nonneoplastic mucosa.
  • METHODS: Forty-seven consecutive patients with early gastric carcinomas or gastric adenomas underwent enhanced-magnification endoscopy following 1.5% acetic acid instillation.
  • RESULTS: Surface patterns of gastric tumors and the surrounding mucosa were classified into five types: type I, small round pits of uniform size and shape; type II, slit-like pits; type III, gyrus and villous patterns; type IV, irregular arrangements and sizes of pattern types I, II and III; type V, destructive patterns of types I, II and III.
  • CONCLUSIONS: Enhanced-magnification endoscopy may be useful for identifying gastric tumors and determining the extent of horizontal spread, especially in tumors of the depressed type.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Endoscopy, Gastrointestinal / methods. Image Enhancement. Stomach Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Neoplasm Staging. Prospective Studies. Video Recording

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  • [CommentIn] J Gastroenterol. 2006 Apr;41(4):397-8 [16741625.001]
  • [Cites] Endoscopy. 2004 Feb;36(2):165-9 [14765314.001]
  • [Cites] Gastrointest Endosc. 2004 Jan;59(1):15-21 [14722541.001]
  • [Cites] Am J Surg Pathol. 1995;19 Suppl 1:S37-43 [7762738.001]
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  • (PMID = 16741612.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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12. Inoue K, Fujisawa T, Haruma K: Assessment of degree of health of the stomach by concomitant measurement of serum pepsinogen and serum Helicobacter pylori antibodies. Int J Biol Markers; 2010 Oct-Dec;25(4):207-12
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  • [Title] Assessment of degree of health of the stomach by concomitant measurement of serum pepsinogen and serum Helicobacter pylori antibodies.
  • The stomach was assessed by measuring serum pepsinogen (PG) and Helicobacter pylori (Hp) antibodies by immunoassay, based on the findings of upper gastrointestinal endoscopy performed on the same day.
  • Gastric cancer was detected in 0.87% (4/462) in group C, 0.19% (1/514) in group B, and 0% (0/660) in group A.
  • All four patients with gastric adenoma were in group C.
  • These findings suggest that the "degree of health" of the stomach can be assessed by measuring serum PG and Hp antibodies.
  • [MeSH-major] Adenoma / diagnosis. Antibodies, Bacterial / blood. Helicobacter pylori / immunology. Pepsinogen A / blood. Stomach / pathology. Stomach Neoplasms / diagnosis

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  • (PMID = 21161942.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Biomarkers; 9001-10-9 / Pepsinogen A
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13. Nakamura M, Shibata T, Tahara T, Yoshioka D, Okubo M, Mizoguchi Y, Kuroda M, Arisawa T, Hirata I: The usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions in the stomach diagnosed as adenoma by using biopsy samples. Gastrointest Endosc; 2010 May;71(6):1070-5
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  • [Title] The usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions in the stomach diagnosed as adenoma by using biopsy samples.
  • BACKGROUND: Therapeutic strategies for flat elevated (0-IIa) lesions in the stomach diagnosed as adenoma by biopsy are currently not established, because some difficulties have previously been reported in the evaluation of vascular patterns alone for the differential diagnosis between adenoma and carcinoma.
  • OBJECTIVE: We attempted to evaluate the 0-IIa lesions diagnosed as adenoma by using magnifying endoscopy with narrow-band imaging (MENBI) to distinguish them as either adenoma or carcinoma.
  • MAIN OUTCOME MEASUREMENTS: The rate of SSs and IMVPs in adenoma and carcinoma.
  • RESULTS: Significant SSs were tubular in the adenoma and unclear in the carcinoma.
  • CONCLUSIONS: Our combined evaluation method using MENBI offers the ability to establish proper therapeutic strategies for lesions that are difficult to identify as adenoma or carcinoma.
  • [MeSH-major] Adenoma / diagnosis. Gastroscopy / methods. Stomach / pathology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Dissection. Gastric Mucosa / surgery. Humans. Image Enhancement. Retrospective Studies

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  • [Copyright] 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20438898.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Vieth M, Vogel C, Kushima R, Borchard F, Stolte M: Pyloric gland adenoma-- how to diagnose? Cesk Patol; 2006 Jan;42(1):4-7
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  • [Title] Pyloric gland adenoma-- how to diagnose?
  • The term "pyloric gland adenoma" reflects its etiogenesis from deep mucoid glands in the stomach.
  • The diagnosis can be confirmed by immunohistochemistry.
  • Typically, pyloric gland adenomas are strongly positive for Mucin 6 (deep mucoid gastric glands).
  • Combination or transdifferentiation with ordinary tubular (intestinal differentiation) adenoma can be observed.
  • The gastric corpus mucosa of elderly female patients with autoimmune gastritis is highly affected.
  • The frequency of pyloric gland adenoma is given in the literature being 2.7% of all gastric polyps.
  • Pyloric gland adenomas can arise in gastric heterotopia and gastric metaplasia in the whole gastrointestinal tract.
  • [MeSH-major] Adenoma / diagnosis. Gastric Mucosa. Stomach Neoplasms / diagnosis

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  • (PMID = 16506593.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 24
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15. Kushima R, Vieth M, Mukaisho K, Sakai R, Okabe H, Hattori T, Neuhaus H, Borchard F, Stolte M: Pyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluation. Virchows Arch; 2005 May;446(5):537-41
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  • [Title] Pyloric gland adenoma arising in Barrett's esophagus with mucin immunohistochemical and molecular cytogenetic evaluation.
  • Pyloric gland adenoma is a recently described and very rare entity.
  • The occurrence of adenoma is very unusual in Barrett's epithelium of the esophagus.
  • We report a case of esophageal polyp showing the features of pyloric gland adenoma, which was surrounded by so-called specialized columnar epithelium.
  • This is the first case of pyloric gland adenoma found to arise in Barrett's epithelium of the esophagus, showing its unstable and precancerous nature.
  • [MeSH-major] Adenoma / diagnosis. Barrett Esophagus / pathology. Cytogenetic Analysis. Gastric Mucosa. Mucins / analysis. Stomach Neoplasms / diagnosis

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  • [Cites] Hum Pathol. 1999 Jul;30(7):745-52 [10414492.001]
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  • (PMID = 15838649.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6; 0 / Mucins
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16. Winkler A, Hinterleitner TA, Högenauer C, Hauser H, Langner C: Juvenile polyposis of the stomach causing recurrent upper gastrointestinal bleeding. Eur J Gastroenterol Hepatol; 2007 Jan;19(1):87-90
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  • [Title] Juvenile polyposis of the stomach causing recurrent upper gastrointestinal bleeding.
  • Endoscopy showed multiple glassy polyps in the stomach, which corresponded to a diffuse mucosal thickening detected by endosonography.
  • The resection specimen showed the gastric mucosa carpeted by numerous glassy pedunculated polyps, measuring 2 cm in largest diameter.
  • Colonoscopy including the terminal ileum revealed a single tubulovillous adenoma, but no hamartomatous polyps, rendering a final diagnosis of juvenile polyposis of the stomach.
  • This case represents the first description of juvenile polyposis causing life-threatening gastric haemorrhage.
  • Thus, although rare, the disease has to be considered in the differential diagnosis of patients with acute upper gastrointestinal tract bleeding.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Gastrointestinal Hemorrhage / etiology. Polyps / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Adult. Gastric Mucosa / pathology. Humans. Male. Recurrence

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  • (PMID = 17206083.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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17. Gheorghe C, Iacob R, Dumbrava M, Becheanu G, Ionescu M: Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions. Chirurgia (Bucur); 2009 Jan-Feb;104(1):17-24
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  • [Title] Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions.
  • We describe for the first time the use of both techniques during the same endoscopic session, in a pilot study, in order to increase the diagnostic yield of histological assessment and provide the staging of the gastric neoplastic lesions thus decreasing the time to therapeutic decision.
  • The indication of CLE/EUS exploration was the presence of a gastric polypoid lesion in 37% of cases, atypical gastric ulcer in 27% of patients, gastric lymphoma 18%, suspicion of gastric cancer recurrence after resection 9% and infiltrating type gastric cancer 9%.
  • Histological assessment after targeted biopsy has established the diagnosis of gastric adenocarcinoma in 55% of cases, gastric lymphoma in 18% of cases, gastric adenoma, gastric GIST and gastric foveolar hyperplasia in 9% of cases respectively.
  • In 2 patients - one case with suspected recurrent gastric cancer after surgery and one case of gastric lymphoma, CLE has indicated normal gastric mucosa.
  • The EUS evaluation showed in one gastric lymphoma patient a lesion interesting the mucosa and submucosa with regional adenopathy and a submucosal lesion with regional adenopathy in the other gastric lymphoma case.
  • [MeSH-major] Endosonography. Microscopy, Confocal. Stomach Neoplasms / pathology. Stomach Neoplasms / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Gastric Mucosa / pathology. Gastric Mucosa / ultrasonography. Humans. Male. Middle Aged. Neoplasm Staging. Pilot Projects. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 19388564.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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18. Yao K, Iwashita A, Tanabe H, Nishimata N, Nagahama T, Maki S, Takaki Y, Hirai F, Hisabe T, Nishimura T, Matsui T: White opaque substance within superficial elevated gastric neoplasia as visualized by magnification endoscopy with narrow-band imaging: a new optical sign for differentiating between adenoma and carcinoma. Gastrointest Endosc; 2008 Sep;68(3):574-80
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  • [Title] White opaque substance within superficial elevated gastric neoplasia as visualized by magnification endoscopy with narrow-band imaging: a new optical sign for differentiating between adenoma and carcinoma.
  • BACKGROUND: The microvascular pattern (MVP) as visualized by magnification endoscopy (ME) is a reliable marker for differentiating between benign and malignant gastric flat lesions.
  • However, in cases of gastric neoplasia of 0-IIa type, it is sometimes impossible to visualize the MVP because a white opaque substance (WOS) obscures the subepithelial MVP.
  • OBJECTIVE: To investigate whether the morphology of the WOS could be a useful optical sign for discriminating between adenoma and carcinoma.
  • MATERIALS: Forty-six gastric neoplasias of only 0-IIa type (18 adenomas and 28 early carcinomas) were evaluated.
  • INTERVENTION: The prevalence and the morphology of the WOS as visualized by ME with narrow-band imaging (NBI) according to histologic type (adenoma vs carcinoma).
  • RESULTS: In cases in which a neoplasia of 0-IIa type showed either WOS with a regular distribution or a regular MVP, the sensitivity and specificity for discriminating adenoma from carcinoma were 94% and 96%, respectively.
  • CONCLUSION: In cases in which the WOS is observed, rather than assessing the MVP, morphologic analysis of the WOS could be an alternative new optical sign for discriminating adenoma from carcinoma when using ME with NBI.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Gastroscopy / methods. Radiographic Magnification. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Cohort Studies. Diagnosis, Differential. Female. Gastric Mucosa / blood supply. Gastric Mucosa / pathology. Humans. Image Enhancement / methods. Immunohistochemistry. Male. Microcirculation. Middle Aged. Neoplasm Staging. Probability. Sensitivity and Specificity

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  • [CommentIn] Gastrointest Endosc. 2009 Aug;70(2):402; author reply 402-3 [19631809.001]
  • (PMID = 18656862.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES: [Double strand break of DNA in gastric adenoma and adenocarcinoma]. Korean J Gastroenterol; 2010 Jan;55(1):19-25
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  • [Title] [Double strand break of DNA in gastric adenoma and adenocarcinoma].
  • The aim of this study was to define the differences in expression of 53BP1 and gamma-H2AX, the markers of DSB, among normal, gastric adenoma, and gastric adenocarcinoma tissues.
  • METHODS: Tissue microarray was made with the tissues taken from 121 patients who underwent gastrectomy for gastric adenocarcinoma, and 51 patients who underwent endoscopic mucosal resection for gastric adenoma.
  • The normal tissues were collected from histologically confirmed tissues with no cellular atypia obtained from the patients with gastric adenocarcinoma.
  • RESULTS: In gastric carcinoma cells, 53BP1 and gamma-H2AX were highly expressed as compared to normal epithelial cells and gastric adenoma (p<0.01).
  • There were no differences in the expression of 53BP1 and gamma-H2AX between normal epithelium and gastric adenoma.
  • The expression of 53BP1 in the adenoma with grade II and III atypism was more elevated than in those with grade I atypism.
  • The expression of 53BP1 and gamma-H2AX were not significantly different according to the clinicopathologic parameters in the patients with gastric adenocarcinoma.
  • CONCLUSIONS: The DSB in DNA seems to be associated with the development of gastric adenocarcinoma, but does not affect the premalignant adenoma cells.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. DNA Breaks, Double-Stranded. Stomach Neoplasms / metabolism

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  • (PMID = 20098063.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / H2AFX protein, human; 0 / Histones; 0 / Intracellular Signaling Peptides and Proteins; 0 / TP53BP1 protein, human; 0 / Tumor Suppressor p53-Binding Protein 1
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20. Jang JS, Lee EJ, Lee SW, Lee JH, Roh MH, Han SY, Choi SR, Jeong JS: [Endoscopic submucosal dissection for early gastric cancer and gastric adenoma]. Korean J Gastroenterol; 2007 Jun;49(6):356-63
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  • [Title] [Endoscopic submucosal dissection for early gastric cancer and gastric adenoma].
  • The aims of this study were to assess the therapeutic efficacy and the safety of ESD in gastric adenoma and in early gastric cancer (EGC).
  • CONCLUSIONS: ESD with IT knife is effective for the treatment of EGC and gastric adenoma even in large or in malignant lesions without definite increased risk of complications.
  • [MeSH-major] Adenoma / surgery. Gastric Mucosa / surgery. Gastroscopy. Stomach Neoplasms / surgery

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  • (PMID = 17641553.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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21. Lee KM, Kim YB, Sin SJ, Jung JY, Hwang JC, Lim SG, Yoo BM, Kim JH, Cho SW: Argon plasma coagulation with submucosal saline injection for gastric adenoma on outpatient basis. Dig Dis Sci; 2009 Dec;54(12):2623-8
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  • [Title] Argon plasma coagulation with submucosal saline injection for gastric adenoma on outpatient basis.
  • Gastric adenoma with low-grade dysplasia (LGD) is a less progressive disease than with high-grade dysplasia; nevertheless, a certain portion of lesions can progress.
  • The purpose of this study was to evaluate the effectiveness of argon plasma coagulation (APC) with submucosa saline injections (APC-SSI) for gastric adenoma with LGD on an outpatient department (OPD) basis.
  • We included 57 patients with 64 lesions of gastric adenoma with LGD.
  • Twelve lesions were adenoma with LGD and two lesions were intramucosal adenocarcinoma.
  • APC-SSI is an effective and safe treatment modality for gastric adenoma with LGD on an OPD basis and it is recommended for patients with risk factors of endoscopic mucosal resection (EMR).
  • After treatment of gastric adenoma, meticulous follow-up endoscopy is recommended for detection of metachronous lesions.
  • [MeSH-major] Adenoma / therapy. Ambulatory Care. Argon Plasma Coagulation. Gastric Mucosa / surgery. Sodium Chloride / administration & dosage. Stomach Neoplasms / therapy

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  • [Copyright] © Springer Science+Business Media, LLC 2008
  • (PMID = 19082886.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 451W47IQ8X / Sodium Chloride
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22. Lee SA, Choi SR, Jang JS, Lee JH, Roh MH, Kim SO, Kim MC, Kim SJ, Jeong JS: Expression of VEGF, EGFR, and IL-6 in gastric adenomas and adenocarcinomas by endoscopic submucosal dissection. Dig Dis Sci; 2010 Jul;55(7):1955-63
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  • [Title] Expression of VEGF, EGFR, and IL-6 in gastric adenomas and adenocarcinomas by endoscopic submucosal dissection.
  • BACKGROUND: The degree of intratumoral microvascular density is thought to affect tumor metastasis and prognosis in various human cancers, including gastric cancer.
  • Despite recent medical advancements, gastric adenoma or adenocarcinoma remains a considerable therapeutic challenge.
  • Endoscopic submucosal dissection (ESD) is a more recent approach that is now commonly used for radical resection of gastric adenoma and adenocarcinoma.
  • AIM AND METHODS: The expression of vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and interleukin-6 (IL-6) are related to the prognosis of gastric adenocarcinoma.
  • However, the expression of these factors in gastric adenoma/adenocarcinoma following ESD has not been clearly evaluated.
  • Here, we report on our study of the expression of VEGF, EGFR, and IL-6 by immunohistochemical staining in extracted tissue from adenoma or adenocarcinoma of the stomach by ESD and subsequent evaluation of the correlation of VEGF, EGFR, and IL-6 with other clinicopathological parameters.
  • The patient cohort consisted of 102 patients with adenoma or adenocarcinoma of the stomach.
  • CONCLUSION: The immunohistochemical expression of IL-6 and VEGF can be considered to be useful for clinical diagnosis and follow-up of adenoma or adenocarcinoma of the stomach.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Interleukin-6 / metabolism. Receptor, Epidermal Growth Factor / metabolism. Stomach Neoplasms / pathology. Vascular Endothelial Growth Factor A / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Biopsy, Needle. Cohort Studies. Female. Gastric Mucosa / pathology. Gastric Mucosa / surgery. Gastroscopy / methods. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Sensitivity and Specificity

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  • (PMID = 19757047.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Interleukin-6; 0 / Vascular Endothelial Growth Factor A; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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23. Szalóki T, Tóth V, Tiszlavicz L, Czakó L: [Diagnostic and therapeutic use of endoscopic resection of gastric mucosa]. Orv Hetil; 2006 Mar 19;147(11):501-7
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  • [Title] [Diagnostic and therapeutic use of endoscopic resection of gastric mucosa].
  • [Transliterated title] A gyomor endoszkópos mucosaresectiója--diagnosztikus és terápiás módszer.
  • BACKGROUND: EMR is a widely used treatment option for gastric adenoma and early gastric cancer, but, there are no data on its use in Hungary.
  • The diagnosis at first biopsy was in situ carcinoma in 3, adenoma with no dysplasia in 19, adenoma with low-grade dysplasia in 2, adenoma with moderate-grade dysplasia in 6, adenoma with high-grade dysplasia in 7, and hyperplastic lesion in 17 cases.
  • The histology of EMR revealed in situ carcinoma in 5, carcinoid in 1, gastrointestinal stromal tumor in 1, adenoma with no dysplasia in 14, adenoma with low-grade dysplasia in 3, adenoma with moderate-grade dysplasia in 9, adenoma with high-grade dysplasia in 1, hyperplastic lesion in 21, and no diagnosis in 1 case.
  • There were no gastric cancer-related deaths during the median follow-up of 33 (1-90) months.
  • In the follow up period we could not observe gastric malignancy in the previously hyperplastic polyp cases.
  • Among adenoma cases one recurrence was seen in the same place and one in another location.
  • One hyperplastic residuum occurred and in one case adenoma has grown in the same place.
  • Biopsy is generally unreliable to diagnose gastric adenoma.
  • Lesions should be fully resected by EMR for a final diagnosis and (depending on the lesion size and type) possibly definitive treatment.
  • [MeSH-major] Gastric Mucosa / surgery. Gastroscopy. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / surgery. Adult. Aged. Aged, 80 and over. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Female. Humans. Hyperplasia / diagnosis. Hyperplasia / surgery. Laser Therapy. Male. Middle Aged

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  • (PMID = 16607858.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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24. Lee JM, Lee HW, Hong YS, Kim ES, Park KS, Cho KB, Hwang JS, Kim HS: [A case of acute myocardial infarction occurred immediately after endoscopic submucosal dissection]. Korean J Gastroenterol; 2010 Oct;56(4):249-54
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  • Endoscopic methods such as endoscopic mucosal resection or endoscopic submucosal dissection (ESD) have been increasingly used for the treatment of gastric adenoma and early gastric cancer.
  • [MeSH-major] Dissection / adverse effects. Myocardial Infarction / diagnosis
  • [MeSH-minor] Acute Disease. Adenoma / surgery. Aged. Coronary Angiography. Endoscopy, Gastrointestinal. Female. Gastric Mucosa / surgery. Humans. Stomach Neoplasms / surgery

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  • (PMID = 20962561.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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25. Carmack SW, Genta RM, Graham DY, Lauwers GY: Management of gastric polyps: a pathology-based guide for gastroenterologists. Nat Rev Gastroenterol Hepatol; 2009 Jun;6(6):331-41
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  • [Title] Management of gastric polyps: a pathology-based guide for gastroenterologists.
  • 1-4% of patients who undergo gastric biopsy have gastric polyps.
  • Hyperplastic polyps, which arise in patients with underlying gastritis, and fundic-gland polyps, which are associated with PPI therapy, are the most common gastric polyps; however, prevalence varies widely relative to the local prevalence of Helicobacter pylori infection and use of PPI therapy.
  • Approximately 20% of biopsy specimens identified endoscopically as polyps have no definite pathological diagnosis.
  • Evaluation of the phenotype of the gastric mucosa that surrounds a lesion will provide significant information crucial to the evaluation, diagnosis and management of a patient.
  • The presence of a gastric adenoma should prompt the search for a coexistent carcinoma.
  • The endoscopic characteristics, histopathology, pathogenesis, and management recommendations of polyps and common polypoid lesions in the stomach are discussed in this Review.
  • [MeSH-major] Adenoma / pathology. Adenoma / therapy. Polyps / pathology. Polyps / therapy. Stomach Neoplasms / pathology. Stomach Neoplasms / therapy
  • [MeSH-minor] Biopsy. Education, Medical, Continuing. Gastritis / epidemiology. Gastritis / pathology. Gastritis / therapy. Gastroenterology. Helicobacter Infections / epidemiology. Helicobacter Infections / pathology. Helicobacter Infections / therapy. Humans. Stomach / pathology

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  • (PMID = 19421245.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 84
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26. Lee SY, Han HS, Lee KY, Hwang TS, Kim JH, Sung IK, Park HS, Jin CJ, Choi KW: Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncol Rep; 2007 May;17(5):1051-5
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  • [Title] Sonic hedgehog expression in gastric cancer and gastric adenoma.
  • Here, we analyzed the degree of hedgehog expression in gastric cancer and precancerous tissue.
  • From August 2005 to May 2006, 52 gastric cancers and 16 gastric adenomas were obtained from surgically or endoscopically resected specimens.
  • Although Shh expression was not related to the location, size, metastatic status, or mucin phenotype of the gastric cancer, the expression was stronger in the tubular type of gastric cancer than in the mucinous and signet-ring cell types (p=0.001).
  • Shh expression was stronger in gastric adenoma than in the diffuse-type gastric cancer (p<0.001), but revealed no difference with that of the intestinal-type gastric cancer (p=0.30).
  • Shh expression is related to the intestinal type of gastric cancer.
  • The stronger Shh expression in intestinal metaplasia and gastric adenoma indicates that hedgehog protein is involved at an early phase of gastric carcinogenesis.
  • [MeSH-major] Adenoma / metabolism. Hedgehog Proteins / biosynthesis. Stomach Neoplasms / metabolism

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  • (PMID = 17390043.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / SHH protein, human
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27. Lee SW, Kang SB, Kim YS, Nam SW, Lee DS, Lee HK, Han SW: [Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma]. Korean J Gastroenterol; 2007 Mar;49(3):152-7
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  • [Title] [Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma].
  • BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical overexpression of c-erbB-2 and c-met proteins according to the histopathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in gastric adenoma and gastric adenocarcinoma.
  • In adenoma, the expression rate of c-met was higher in high grade dysplasia (94%) than in low grade dysplasia (22%).
  • CONCLUSIONS: c-erbB-2 would be involved in the development of relatively early stage gastric carcinogenesis. c-erbB-2 is related with histologic type and c-met with lymph node metastasis in gastric carcinomas.
  • Although meaning for the expression of these proteins in gastric carcinomas would be different, these proteins may play as important oncogenes in gastric carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Proto-Oncogene Proteins c-met / metabolism. Receptor, ErbB-2 / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 18172343.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, ErbB-2
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28. Jung JT, Lee CH, You SS, Ha HK, Bae JS, Kwon JG, Kim EY, Kim HG, Cho CH, Shin IH: [Grading of histology, expression of apoptosis and cell proliferation in gastric mucosa adjacent to gastric adenoma or adenocarcinoma]. Korean J Gastroenterol; 2005 Oct;46(4):269-75
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  • [Title] [Grading of histology, expression of apoptosis and cell proliferation in gastric mucosa adjacent to gastric adenoma or adenocarcinoma].
  • BACKGROUND/AIMS: Helicobacter pylori (H. pylori) infection can lead to gastric adenoma and carcinoma through atrophic gastritis and intestinal metaplasia.
  • Imbalance between apoptosis and proliferation may play a role in gastric carcinogenesis.
  • We tried to investigate H. pylori infection rate, grade of gastritis, environmental risk factors, expression rate of apoptosis and cell proliferation in mucosa adjacent to tumor, and we also tried to find significant factors associated with gastric carcinogenesis.
  • METHODS: Endoscopically diagnosed twenty cases of intestinal type gastric carcinoma, 20 cases of gastric adenoma, and 40 cases of control (normal or gastritis) were enrolled. H. pylori infection rate, histologic grading, apoptosis and immunohistochemical stain (Ki-67 and p53) to check mucosal proliferation were done in endoscopically biopsied tissues at antrum and body at least 2 cm apart from adenoma or carcinoma.
  • In the multivariate analysis, only atrophy of gland was a significant risk factor for adenoma compared to control group (OR 3.7).
  • CONCLUSIONS: Intestinal metaplasia in antrum and alcohol drinking are significant risk factors for gastric carcinoma.
  • Degree of mucosal proliferation and apoptosis in gastric mucosa adjacent to tumor are not significantly different in three groups.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Apoptosis. Cell Proliferation. Gastric Mucosa / pathology. Stomach Neoplasms / pathology

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  • (PMID = 16247270.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
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29. Katsube T, Konnno S, Hamaguchi K, Shimakawa T, Naritaka Y, Ogawa K, Aiba M: The efficacy of endoscopic mucosal resection in the diagnosis and treatment of group III gastric lesions. Anticancer Res; 2005 Sep-Oct;25(5):3513-6
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  • [Title] The efficacy of endoscopic mucosal resection in the diagnosis and treatment of group III gastric lesions.
  • The final diagnosis after EMR broadly classified the lesions as adenocarcinoma or adenoma.
  • RESULTS: Adenocarcinoma was identified in 16 patients (37.2%) and adenoma in 27 patients (62.8%).
  • [MeSH-major] Adenocarcinoma / surgery. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adenoma / surgery. Aged. Biopsy. Endoscopy, Gastrointestinal. Female. Gastric Mucosa / pathology. Gastric Mucosa / surgery. Humans. Male

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  • (PMID = 16101171.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Greece
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30. Kim JY, Park DY, Kim GH, Choi KU, Lee CH, Huh GY, Sol MY, Song GA, Jeon TY, Kim DH, Sim MS: Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma. Histol Histopathol; 2005 04;20(2):543-9
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  • [Title] Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma.
  • The purpose of this study was to elucidate Smad4 expression and localization in 65 gastric adenomas, 49 intestinal-type and 39 diffuse type of gastric adenocarcinomas (including 12 cases of fresh frozen tissue) using Real-time RT-PCR and immunohistochemistry.
  • Real-time RT-PCR showed that intestinal type gastric adenocarcinomas have higher Smad4 mRNA expression than diffuse type gastric adenocarcinomas.
  • Immunohistochemical stain for Smad4 revealed that expression of Smad4 was significantly lower in diffuse-type gastric adenocarcinoma than intestinal-type gastric adenocarcinomas.
  • Also, higher Smad4 protein expression in intestinal type gastric adenocarcinomas than overall gastric adenoma was noted.
  • The rate of reduced Smad4 expression was higher in advanced gastric cancer than early gastric cancer.
  • These results suggest that Smad4 might play different roles in human gastric carcinogenesis, especially between intestinal type and diffuse type of gastric adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenoma / genetics. Adenoma / metabolism. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Stomach Neoplasms / genetics. Stomach Neoplasms / metabolism. Trans-Activators / genetics. Trans-Activators / metabolism
  • [MeSH-minor] Adult. Aged. Base Sequence. Female. Gastric Mucosa / metabolism. Gene Expression. Humans. Immunohistochemistry. Male. Middle Aged. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Smad4 Protein. Transforming Growth Factor beta / metabolism

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  • (PMID = 15736060.001).
  • [ISSN] 0213-3911
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / SMAD4 protein, human; 0 / Smad4 Protein; 0 / Trans-Activators; 0 / Transforming Growth Factor beta
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31. Kuroki T, Tajima Y, Tsutsumi R, Mishima T, Kitasato A, Adachi T, Kanematsu T: Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma. Am J Surg; 2006 Jun;191(6):823-6
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  • [Title] Inferior branch-preserving superior head resection of the pancreas with gastric wall-covering method for intraductal papillary mucinous adenoma.
  • We describe a surgical technique of superior head resection of the pancreas with inferior branch preservation followed by a gastric wall-covering method for the prevention of pancreatic leakage in patients with IPMN of the pancreas head.
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Carcinoma, Pancreatic Ductal / surgery. Pancreatectomy / methods. Pancreatic Neoplasms / surgery. Stomach / surgery
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Anastomosis, Surgical. Cholangiopancreatography, Endoscopic Retrograde / methods. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 16720158.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Jung MK, Jeon SW, Park SY, Cho CM, Tak WY, Kweon YO, Kim SK, Choi YH, Bae HI: Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation. Surg Endosc; 2008 Dec;22(12):2705-11
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  • [Title] Endoscopic characteristics of gastric adenomas suggesting carcinomatous transformation.
  • BACKGROUND: Currently, endoscopic resections, including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), are widely performed for the management of gastric neoplasia.
  • Gastric adenoma was diagnosed initially for all the patients.
  • These variables were analyzed and compared between an adenoma group (51 cases) and a carcinoma group (63 cases) on the basis of postresection diagnosis.
  • The diameter of the lesions was 14.6 +/- 8.2 mm in the adenoma group and 15.4 +/- 7.4 mm in the carcinoma group.
  • Characteristics of gastric adenomas such as a depressed type, red color, and ulceration that may have foci of carcinomas in other parts of the adenomas also should be considered for endoscopic resection.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Cell Transformation, Neoplastic / pathology. Gastroscopy. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Disease Progression. Dissection / methods. Female. Gastric Mucosa / pathology. Humans. Male. Middle Aged. Risk Factors. Stomach Ulcer / etiology. Stomach Ulcer / pathology

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  • (PMID = 18401651.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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33. Lee DS, Kang SB, Baek JT, Nam SW, Lee KM, Ahn BM, Lee EH, Han SW, Chung IS: [Immunohistochemical expression of bcl-2, bcl-xL, bax, p53 proteins in gastric adenoma and adenocarcinoma]. Korean J Gastroenterol; 2005 Jun;45(6):394-400
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  • [Title] [Immunohistochemical expression of bcl-2, bcl-xL, bax, p53 proteins in gastric adenoma and adenocarcinoma].
  • BACKGROUND/AIMS: The aim of this study was to investigate the immunohistochemical expression of bcl-2, bcl-xL, bax, and p53 proteins according to the pathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node metastasis, and TNM stage in the gastric adenoma and gastric adenocarcinoma.
  • METHODS: Immunohistochemical staining using monoclonal bcl-2, bcl-xL, bax, p53 antibodies were performed on paraffin embedded specimens from forty-one gastric adenomas and 100 gastric adenocarcinomas.
  • CONCLUSIONS: Bcl-2 protein would be related with the development of gastric adenoma, especially with high grade dysplasia.
  • Bcl-xL and p53 proteins would be involved in the development of relatively early stage of gastric adenocarcinoma but not in tumor progression.
  • Bax protein would be involved in the development of gastric adenocarcinoma and related with depth of invasion, lymph node metastasis, and TNM stage.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Stomach Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism. bcl-2-Associated X Protein / metabolism. bcl-X Protein / metabolism

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  • (PMID = 15973073.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein; 0 / bcl-X Protein
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34. Köklü S, Başar O, Akbal E, Ibiş M: Gastric serrated adenoma polyp treated with endoscopic band ligation (with video). Surg Laparosc Endosc Percutan Tech; 2010 Dec;20(6):e204-5
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  • [Title] Gastric serrated adenoma polyp treated with endoscopic band ligation (with video).
  • Serrated adenoma of the stomach has been very rarely reported.
  • A 34-year-old woman underwent upper gastrointestinal endoscopy showing a serrated adenoma polyp at the posterior wall of the junction of the fundus and body of the stomach.
  • At the follow-up, the base of the polyp was free of adenoma.
  • Beside several other polypectomy techniques, the band ligation technique may be used in removing of the gastric polyps, which is cheap, safe and technically easy to perform.
  • [MeSH-major] Adenoma / surgery. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Gastric Fundus. Humans. Ligation

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  • (PMID = 21150403.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Video-Audio Media
  • [Publication-country] United States
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35. Ding XW, Luo HS, Jin X, Yan JJ, Ai YW: Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines. Med Oncol; 2007;24(3):345-50
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  • [Title] Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines.
  • The aim of this study is to investigate expression of Eag1 potassium channel in gastric cancer and its role in cancer cells growth.
  • The expression of Eag1 for gasric cancer patients and cell lines as well as gastric adenoma was investigated by immunohistochemistry and reverse transcription polymerase chain reaction.
  • Frequency of positive expression of Eag1 protein was 70.5% (67/95) and Eag1 mRNA was 68.2% (15/22) in gastric cancer primary tissues.
  • Eag1 mRNA was positively expressed in two gastric cell lines.
  • Eag1 protein and mRNA were negatively expressed in paired non-cancerous matched tissues and 5 cases of adenoma tissues.
  • The study indicates Eag1 is aberrantly expressed in gastric cancer tissues and cell lines and associated with cancer lymph node metastasis and stage and play an important role in the proliferation of gastric cancer cells.
  • [MeSH-major] Adenoma / metabolism. Ether-A-Go-Go Potassium Channels / metabolism. Gene Expression Regulation, Neoplastic. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Cell Line, Tumor. Cell Proliferation. Chi-Square Distribution. Female. Humans. Immunohistochemistry. Lymphatic Metastasis / diagnosis. Male. Matched-Pair Analysis. Middle Aged. Neoplasm Metastasis / physiopathology. RNA, Messenger / analysis. Reference Values

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  • (PMID = 17873312.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ether-A-Go-Go Potassium Channels; 0 / KCNH1 protein, human; 0 / RNA, Messenger
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36. Imaeda H, Hosoe N, Kashiwagi K, Ida Y, Saito Y, Suzuki H, Aiura K, Ogata H, Kumai K, Hibi T: Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia. J Gastroenterol Hepatol; 2010 Apr;25(4):706-11
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  • [Title] Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia.
  • BACKGROUND: Autofluorescence (AF) videoendoscopy has an advantage over ordinary videoendoscopy in the diagnosis of gastric neoplasias, and the aim of the present study was to evaluate the effectiveness of using the SAFE-3000 videoendoscopy system to diagnose superficial gastric neoplasias.
  • METHODS: Ordinary videoendoscopy, AF videoendoscopy, and chromoendoscopy (CE) were used to diagnose the tumor existence and extent in 14 patients with gastric adenoma, 40 patients with intestinal-type early gastric cancer (EGC) (10 protruded, and 30 depressed), and nine patients with diffuse-type EGC.
  • RESULTS: For gastric adenomas the diagnostic accuracy between the AF images and white light (WL) images did not differ significantly, and for protruded intestinal-type EGCs and diffuse-type EGCs the diagnostic accuracy did not differ significantly between any of the types of images.
  • The detection rate of pink or orange color in AF images was significantly higher for protruded intestinal-type EGCs than gastric adenomas (P = 0.005), depressed intestinal-type EGCs (P < 0.001), and diffuse-type EGCs (P = 0.027).
  • CONCLUSIONS: Autofluorescence videoendoscopy using the SAFE-3000 system for gastric neoplasias might be useful for diagnosing depressed intestinal-type early gastric cancers.
  • The detection of orange or pink color in AF images may be efficacious in discriminating protruded intestinal-type early gastric cancers from gastric adenomas.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal. Stomach Neoplasms / pathology. Video Recording
  • [MeSH-minor] Aged. Cell Differentiation. Diagnosis, Differential. Equipment Design. Female. Fluorescence. Humans. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests

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  • (PMID = 20492326.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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37. Cho YE, Kim JY, Kim YW, Park JH, Lee S: Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma. Hum Pathol; 2009 Jul;40(7):975-81
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  • [Title] Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma.
  • We investigated the expression profile of human growth and transformation-dependent protein using immunohistochemistry in gastric tissues including cancer (n = 138), adenoma (n = 37), intestinal metaplasia (n = 20), and normal gastric epithelium (n = 20), then correlated human growth and transformation-dependent protein expression in tumors with clinicopathologic features.
  • Human growth and transformation-dependent protein showed strong staining in the cytoplasm of intestinal-type adenocarcinoma and gastric adenoma, whereas normal gastric antral mucosa showed no staining.
  • Human growth and transformation-dependent protein expression in gastric cancer showed a close association with the Lauren classification, tumor stage, and Ki-67 proliferation index.
  • These findings suggest that human growth and transformation-dependent protein expression is a common occurrence during the progression from a normal gastric mucosa to an intestinal-type carcinoma and may be associated with tumor cell proliferation activity.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Membrane Proteins / biosynthesis. Mitochondrial Proteins / biosynthesis. Stomach Neoplasms / metabolism

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  • (PMID = 19269009.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FAM162A protein, human; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Mitochondrial Proteins
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38. Swain JM, Adams RB, Farnell MB, Que FG, Sarr MG: Gastric and pancreatoduodenal resection for malignant lesions after previous gastric bypass--diagnosis and methods of reconstruction. Surg Obes Relat Dis; 2010 Nov-Dec;6(6):670-5
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  • [Title] Gastric and pancreatoduodenal resection for malignant lesions after previous gastric bypass--diagnosis and methods of reconstruction.
  • BACKGROUND: The diagnosis and treatment of gastric and pancreatoduodenal neoplasms after previous gastric bypass has been limited.
  • The diagnosis and resection of these neoplasms and restoration of biliopancreatic intestinal continuity pose challenges.
  • We present a 2-institutional experience of diagnosis and reconstruction after resection of gastric and pancreatoduodenal neoplasms and discuss the technical options for reconstruction.
  • METHODS: The medical records were reviewed retrospectively from 2003 to 2009 for patients with previous gastric bypass who developed a gastric or pancreatoduodenal neoplasm.
  • RESULTS: Of the available patients, 7 were identified with 2 remnant gastric cancers (2 signet ring cell adenocarcinomas), 4 pancreatic neoplasms (2 adenocarcinomas and 2 neuroendocrine cancers), and 1 ampullary cancer.
  • The gastric neoplasms required complete remnant gastrectomy but did not require additional gastrointestinal reconstruction.
  • CONCLUSION: Gastric and pancreatoduodenal neoplasms after previous gastric bypass, although rare, will most likely increase as the number of bariatric operations increases.
  • Resection is feasible and safe but could require complex gastric and pancreatobiliary reconstruction.
  • [MeSH-major] Digestive System Surgical Procedures / methods. Duodenal Neoplasms / surgery. Gastrectomy / methods. Gastric Bypass. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma, Islet Cell / diagnosis. Adenoma, Islet Cell / epidemiology. Adenoma, Islet Cell / surgery. Aged. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / epidemiology. Carcinoma, Neuroendocrine / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / epidemiology. Common Bile Duct Neoplasms / surgery. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • [Copyright] Copyright © 2010 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20627707.001).
  • [ISSN] 1878-7533
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Noji S, Takayanagi K: A case of laughter therapy that helped improve advanced gastric cancer. Jpn Hosp; 2010 Jul;(29):59-64
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  • [Title] A case of laughter therapy that helped improve advanced gastric cancer.
  • We have reported the case of a patient diagnosed as having advanced gastric cancer at the age of 88 years old.
  • An endoscopy revealed a type-2 gastric cancer of 25 x 30 mm in the lesser curvature of the middle stomach body and an IIa gastric cancer with T2 SS and cardiac accessory lesions.
  • One year and seven months later, an endoscopy of the lesser curvature of the middle stomach body indicated that the lesions clearly improved with a morphological reduction into IIa + IIc masses.
  • A tissue biopsy revealed that nucleus abnormality clearly improved from the initial diagnosis, with no irregularity in size.
  • The suspected lesion was localized to a limited area near the stomach wall.
  • Although partial gastric adenocarcinoma was suspected, the cancers turned into gastric adenoma, atrophic gastritis, and enteroepithelium metaplastic carcinoma.
  • Now, five years after the initial diagnosis, she maintains a good condition.
  • [MeSH-major] Laughter Therapy. Stomach Neoplasms

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  • (PMID = 21706962.001).
  • [ISSN] 0910-1004
  • [Journal-full-title] Japan-hospitals : the journal of the Japan Hospital Association
  • [ISO-abbreviation] Jpn Hosp
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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40. Futagami S, Hiratsuka T, Shindo T, Horie A, Hamamoto T, Suzuki K, Kusunoki M, Miyake K, Gudis K, Crowe SE, Tsukui T, Sakamoto C: Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer. Helicobacter; 2008 Jun;13(3):209-18
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  • [Title] Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
  • However, little is known about the localization of APE-1 in Helicobacter pylori-infected gastric mucosa or its role in the development of gastric cancer.
  • To investigate the role of APE-1 in the development of gastric cancer, we examined APE-1 expression and localization in cultured cells and gastric biopsies from patients with H. pylori-infected gastritis or gastric adenoma, and from surgically resected gastric cancer.
  • METHODS: APE-1 mRNA and protein expression were determined in H. pylori (CagA+) water-extract protein (HPWEP)-stimulated MKN-28 cells, gastric adenocarcinoma cell-line (AGS) cells, and human peripheral macrophages by real-time polymerase chain reaction and Western blot analysis.
  • Localization of APE-1 and IkappaBalpha phosphorylation in gastric adenoma and gastric cancer tissues were evaluated by single- and double-label immunohistochemistry.
  • Eradication therapy significantly reduced both APE-1 and 8-OHdG expression levels in the gastric mucosa.
  • APE-1 expression was mainly localized in epithelial cells within gastric adenoma and in mesenchymal cells of gastric cancer tissues.
  • APE-1 expression in gastric cancer tissues was significantly reduced compared to that in H. pylori-infected gastric adenoma, while 8-OHdG index and IkappaBalpha phosphorylation levels did not differ between these two neoplastic tissue types.
  • Co-localization of APE-1 and IkappaBalpha phosphorylation was observed not in gastric cancer cells but in gastric adenoma cells.
  • CONCLUSION: H. pylori infection is associated with increased APE-1 expression in human cell lines and in gastric tissues from subjects with gastritis and gastric adenomas.
  • The observed distinct expression patterns of APE-1 and 8-OHdG in gastric adenoma and gastric cancer tissues may provide insight into the progression of these conditions and warrants further investigation.
  • [MeSH-major] DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism. Gastritis / enzymology. Gastritis / microbiology. Helicobacter Infections / enzymology. Helicobacter pylori. Stomach Neoplasms / enzymology. Stomach Neoplasms / microbiology
  • [MeSH-minor] Adenoma / enzymology. Adenoma / genetics. Adenoma / microbiology. Adult. Aged. Cells, Cultured. Female. Gastric Mucosa / metabolism. Gastric Mucosa / microbiology. Humans. Male. Middle Aged. RNA, Messenger / metabolism

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  • (PMID = 18466396.001).
  • [ISSN] 1523-5378
  • [Journal-full-title] Helicobacter
  • [ISO-abbreviation] Helicobacter
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK061769
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 4.2.99.18 / APEX1 protein, human; EC 4.2.99.18 / DNA-(Apurinic or Apyrimidinic Site) Lyase
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41. Kato M, Kaise M, Yonezawa J, Toyoizumi H, Yoshimura N, Yoshida Y, Kawamura M, Tajiri H: Magnifying endoscopy with narrow-band imaging achieves superior accuracy in the differential diagnosis of superficial gastric lesions identified with white-light endoscopy: a prospective study. Gastrointest Endosc; 2010 Sep;72(3):523-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnifying endoscopy with narrow-band imaging achieves superior accuracy in the differential diagnosis of superficial gastric lesions identified with white-light endoscopy: a prospective study.
  • BACKGROUND: Conventional, white-light imaging endoscopy (WLE) results in a significant number of misdiagnoses in early gastric cancer.
  • Magnifying endoscopy combined with narrow-band imaging (ME-NBI) is more accurate in the diagnosis of gastric cancer when the diagnostic triad of the disappearance of fine mucosal structure, microvascular dilation, and heterogeneity is used.
  • OBJECTIVE: The aim of the present study was to evaluate the superiority of ME-NBI in the differential diagnosis of superficial gastric lesions identified with conventional WLE.
  • PATIENTS: This study involved patients who underwent WLE and ME-NBI for surveying synchronous or metachronous cancers because they had a high risk of gastric cancer.
  • INTERVENTION: Patients with superficial gastric lesions that were diagnosed by WLE as cancer or non-cancer with a slight suspicion of cancer were prospectively enrolled in the study.
  • MAIN OUTCOME MEASUREMENTS: Sensitivity and specificity for the diagnosis of gastric cancer, with pathology as the criterion standard.
  • Fourteen of the 201 lesions were pathologically proven as gastric cancer; the others were noncancerous lesions.
  • The sensitivity and specificity for ME-NBI diagnosis with the use of the triad (92.9% and 94.7%, respectively) were significantly better than for WLE (42.9% and 61.0%, respectively; P < .0001).
  • LIMITATIONS: Single center and a highly selected population at high risk for gastric cancer.
  • CONCLUSION: ME-NBI achieved superior accuracy in the differential diagnosis of superficial gastric lesions identified with WLE.
  • Thus, ME-NBI may increase the diagnostic value of endoscopy in a population at high risk of gastric cancer.
  • [MeSH-major] Adenocarcinoma / blood supply. Adenocarcinoma / diagnosis. Adenoma / blood supply. Adenoma / diagnosis. Gastric Mucosa / blood supply. Gastric Mucosa / pathology. Gastroscopes. Image Enhancement / instrumentation. Precancerous Conditions / blood supply. Precancerous Conditions / diagnosis. Stomach Neoplasms / blood supply. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Dissection. Female. Fluorescence. Humans. Male. Microvessels / pathology. Middle Aged. Prospective Studies

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  • [Copyright] Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20598685.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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42. Kimura T, Muguruma N, Ito S, Okamura S, Imoto Y, Miyamoto H, Kaji M, Kudo E: Infrared fluorescence endoscopy for the diagnosis of superficial gastric tumors. Gastrointest Endosc; 2007 Jul;66(1):37-43
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  • [Title] Infrared fluorescence endoscopy for the diagnosis of superficial gastric tumors.
  • We developed an IR fluorescence endoscope (IRFE) to observe superficial gastric tumors and assessed its clinical usefulness.
  • OBJECTIVE: To evaluate the clinical usefulness of an IRFE for the assessment of superficial gastric tumors.
  • PATIENTS: Thirty patients with gastric tumors were enrolled in this study, and their lesions were subjected to endoscopic submucosal dissection (ESD), or laparoscopic gastrectomy after observation with the IRFE.
  • METHODS: Gastric lesions were subjected to conventional observation, followed by IR fluorescence observation before and after intravenous ICG (0.01 mg/kg) injection.
  • RESULTS: Fluorescence was positive in 8 of 10 gastric cancers with submucosal invasion (80%) and 1 of 20 adenomas or intramucosal gastric cancers (5%); the difference was statistically significant (P<.01).
  • CONCLUSION: IRFE is a useful diagnostic tool for estimating the invasivity of gastric tumors.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Endoscopy, Gastrointestinal / methods. Fluorescence. Infrared Rays. Stomach Neoplasms / pathology

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  • [CommentIn] Gastrointest Endosc. 2008 Feb;67(2):386; author reply 386-7 [18226708.001]
  • (PMID = 17591472.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; IX6J1063HV / Indocyanine Green
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43. Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Tsuneyama K, Takano Y: Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings. Appl Immunohistochem Mol Morphol; 2007 Dec;15(4):432-40
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  • [Title] Low expression of FHIT and PTEN correlates with malignancy of gastric carcinomas: tissue-array findings.
  • To clarify the roles of FHIT (fragile histidine triad) and PTEN (phosphatase and tensin homology deleted from human chromosome 10) expression in the genesis and progression of gastric cancers, we examined expression of FHIT and PTEN on tissue microarray containing gastric normal mucosa (n=49), adenoma (n=49), noncancerous mucosa adjacent to carcinoma (n=84) and carcinoma (n=249) by immunohistochemistry.
  • The results showed expression of FHIT and PTEN were lower in gastric carcinoma than those in normal mucosa, noncancerous mucosa adjacent to carcinoma and adenoma of the stomach (P<0.05).
  • FHIT and PTEN expression showed a significantly negative association with depth of invasion, lymphatic invasion, and lymph node metastasis, liver metastasis, and Union Internationale Contre le Cancer staging of gastric carcinoma (P<0.05).
  • Intestinal-type gastric carcinomas highly expressed FHIT and PTEN protein, compared with diffuse-type ones (P<0.05).
  • Expression of FHIT and PTEN were positively related with expression of p53 and cysteine protease protein 32 in gastric carcinoma (P<0.05), as well as favorable prognosis of the patients with the tumors (P<0.05).
  • There was positive relationship between FHIT and PTEN expression in gastric carcinoma (P<0.05).
  • It was suggested that down-regulated expression of FHIT and PTEN contributed to gastric carcinogenesis possibly by involving in the imbalance between apoptosis and proliferation of cells.
  • Their altered expression underlay the molecular basis of invasion, metastasis, differentiation of gastric carcinoma.

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  • (PMID = 18091387.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / fragile histidine triad protein; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.6.- / Acid Anhydride Hydrolases
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44. Sakai Y, Eto R, Kasanuki J, Kondo F, Kato K, Arai M, Suzuki T, Kobayashi M, Matsumura T, Bekku D, Ito K, Nakamoto S, Tanaka T, Yokosuka O: Chromoendoscopy with indigo carmine dye added to acetic acid in the diagnosis of gastric neoplasia: a prospective comparative study. Gastrointest Endosc; 2008 Oct;68(4):635-41
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  • [Title] Chromoendoscopy with indigo carmine dye added to acetic acid in the diagnosis of gastric neoplasia: a prospective comparative study.
  • BACKGROUND: Conventional endoscopy and chromoendoscopy with indigo carmine dye are usually performed for recognizing adequate tumor-negative lateral margins for successful endoscopic resection of gastric neoplasia.
  • PATIENTS: Forty-seven consecutive patients (53 lesions) with early gastric cancer and gastric adenomas who underwent endoscopic submucosal dissection (ESD) from April 2006 to July 2007 were studied.
  • The applicability of this method for gastric neoplasia merits further investigation.
  • [MeSH-major] Acetic Acid. Endoscopy / methods. Indigo Carmine. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma / surgery. Adult. Aged. Aged, 80 and over. Female. Gastroscopy / methods. Humans. Male. Middle Aged. Observer Variation. Prospective Studies

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  • [CommentIn] Gastrointest Endosc. 2009 Jun;69(7):1407-8 [19481666.001]
  • (PMID = 18561923.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] D3741U8K7L / Indigo Carmine; Q40Q9N063P / Acetic Acid
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45. Kim YJ, Park JC, Kim JH, Shin SK, Lee SK, Lee YC, Chung JB: Histologic diagnosis based on forceps biopsy is not adequate for determining endoscopic treatment of gastric adenomatous lesions. Endoscopy; 2010 Aug;42(8):620-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologic diagnosis based on forceps biopsy is not adequate for determining endoscopic treatment of gastric adenomatous lesions.
  • BACKGROUND AND STUDY AIMS: Controversy persists around the treatment of gastric low-grade dysplasia (LGD).
  • The aim of this study was to investigate possible indications for the endoscopic resection of gastric LGD through analysis of the histologic discrepancies between specimens of gastric LGD obtained by forceps biopsy and by endoscopic mucosal resection (EMR), and of their clinicopathologic characteristics.
  • PATIENTS AND METHODS: The study involved 293 gastric LGD that were histologically proven on the basis of forceps biopsy in Severance Hospital between January 2004 and December 2007.
  • CONCLUSIONS: We should consider endoscopic resection for gastric LGD that are 2 cm or more in size and do not have whitish discoloration.
  • [MeSH-major] Adenoma / pathology. Biopsy / methods. Gastric Mucosa / pathology. Gastroscopy. Precancerous Conditions / pathology. Stomach Neoplasms / pathology

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  • [Copyright] Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20623445.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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46. Kwon JH, Choi MG, Lee SW, Shu XX, Bae SH, Choi JY, Yoon SK, Cho YK, Park JM, Lee IS, Kim SW, Chung IS: Trends of Gastrointestinal Diseases at a Single Institution in Korea over the Past Two Decades. Gut Liver; 2009 Dec;3(4):252-8
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  • The most prevalent disease in 1990 was gastric cancer, followed by appendicitis and colorectal cancer.
  • However, by 2006, gastric cancer, colon cancer, and colon adenoma or polyps had become the most prevalent diseases.
  • Although gastric cancer showed a decreasing trend, the rate of colon cancer doubled over two decades.
  • Furthermore, rates of detection and endoscopic treatment of early gastric cancer and adenoma of the stomach and colon have increased noticeably.

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  • [Cites] Lancet Oncol. 2005 Nov;6(11):871-6 [16257795.001]
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  • (PMID = 20431757.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852723
  • [Keywords] NOTNLM ; Epidemiology / Gastrointestinal diseases / Korea / Trends
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47. Gockel I, Trinh TT, Mildenberger P, Oberholzer K, Schmitt T, Eckardt VF, Junginger T: [Achalasia or pseudoachalasia? Problems of diagnostic and treatment decisions in two cases]. Dtsch Med Wochenschr; 2008 Feb;133(7):290-4
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  • DIAGNOSIS, TREATMENT AND COURSE: Patient 1 had an achalasia and an esophagogastric fistula with recurrent aspiration pneumonia, bronchial carcinoma being excluded.
  • The fistula was closed by suture, followed by cardiomyotomy and anterior partial gastric fundectomy.
  • CT of the thorax and abdomen established the diagnosis of a pseudoachalasia due to an adenoma of the cardia, proven by biopsy at an exploratory laparotomy.
  • The differential diagnosis between the two conditions may be difficult with routine methods and other imaging modalities: exploratory surgery may be necessary for a definitive diagnosis.
  • [MeSH-major] Deglutition Disorders / etiology. Esophageal Achalasia / diagnosis. Esophageal Achalasia / therapy. Gastroesophageal Reflux / etiology
  • [MeSH-minor] Adenoma / complications. Adenoma / diagnosis. Adenoma / surgery. Age Factors. Aged, 80 and over. Bronchoscopy. Cardia. Diagnosis, Differential. Endoscopy, Digestive System. Esophageal Fistula / complications. Esophageal Fistula / diagnosis. Esophageal Fistula / surgery. Female. Gastric Fistula / complications. Gastric Fistula / diagnosis. Gastric Fistula / surgery. Humans. Male. Manometry. Middle Aged. Stents. Stomach Neoplasms / complications. Stomach Neoplasms / diagnosis. Stomach Neoplasms / surgery. Tomography, X-Ray Computed. Weight Loss

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  • (PMID = 18253919.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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48. Yagi K, Aruga Y, Nakamura A, Sekine A, Umezu H: The study of dynamic chemical magnifying endoscopy in gastric neoplasia. Gastrointest Endosc; 2005 Dec;62(6):963-9
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  • [Title] The study of dynamic chemical magnifying endoscopy in gastric neoplasia.
  • BACKGROUND: We assessed the usefulness of acetic acid-enhanced magnifying endoscopy in the diagnosis of gastric neoplasia.
  • METHODS: Forty-five patients (27 men, 18 women; median age 61.6 years) with gastric carcinoma or adenoma were enrolled in a prospective trial of enhanced magnifying endoscopy after instillation of 1.5% acetic acid.
  • Acetic acid-enhanced magnified views of carcinoma or adenoma and the surrounding non-neoplastic mucosa were observed, and the duration of whitening time of each lesion was recorded.
  • The mean duration of whitening differed with each histologic type: low-grade adenoma, 94 seconds; high-grade adenoma, 24.3 seconds; noninvasive carcinoma, 20.1 seconds; invasive intramucosal carcinoma, 3.5 seconds; and submucosal carcinoma or beyond, 2.5 seconds.
  • CONCLUSIONS: Acetic acid-enhanced magnifying endoscopy was useful for the diagnosis of gastric adenocarcinoma.
  • [MeSH-major] Acetic Acid. Gastric Mucosa / pathology. Gastroscopy. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Carcinoma / diagnosis. Carcinoma / pathology. Female. Humans. Indicators and Reagents. Male

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  • (PMID = 16301045.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indicators and Reagents; Q40Q9N063P / Acetic Acid
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49. Vieth M, Kushima R, Mukaisho K, Sakai R, Kasami T, Hattori T: Immunohistochemical analysis of pyloric gland adenomas using a series of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53. Virchows Arch; 2010 Nov;457(5):529-36
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  • A pyloric gland adenoma (PGA) of the stomach was first described in a book chapter in 1976 by Kurt Elster and has been rarely reported in the literature.
  • A transition from gastric to intestinal differentiation can be observed focally as depicted by Mucin 2 and CD10 in 65% of the cases.
  • The gastric corpus mucosa of elderly patients with either Helicobacter pylori gastritis or autoimmune gastritis is highly affected.
  • The diagnosis of PGA can be confirmed immunohistochemically by staining against apomucin 6 and apomucin 5AC.
  • Focal intestinal differentiation supports the hypothesis that gastric adenocarcinomas can initially develop from carcinomas of the gastric type and transform into intestinal type later on.
  • [MeSH-major] Adenoma / metabolism. Biomarkers, Tumor / analysis. Gastric Mucosa / metabolism. Stomach Neoplasms / metabolism

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  • [Cites] Int J Cancer. 1993 Dec 2;55(6):904-8 [8253526.001]
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  • (PMID = 20827489.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Mucin 5AC; 0 / Mucin-2; 0 / Tumor Suppressor Protein p53; EC 3.4.24.11 / Neprilysin
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50. Park DI, Park SH, Yoo TW, Kim HS, Yang SK, Byeon JS, Koh BM, Kim JO, Shim KN, Jeen YT, Lee BI, Choi KY, Lee HL, Han DS, Baek I, Park CH, Park SJ: The prevalence of colorectal neoplasia in patients with gastric cancer: a Korean Association for the Study of Intestinal Disease (KASID) Study. J Clin Gastroenterol; 2010 Feb;44(2):102-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prevalence of colorectal neoplasia in patients with gastric cancer: a Korean Association for the Study of Intestinal Disease (KASID) Study.
  • GOALS: The goal of this study was to determine the prevalence of colorectal neoplasia, using colonoscopy surveillance, in a cohort of patients with gastric cancers.
  • BACKGROUND: The association between gastric cancer and colorectal cancer has been conflicting.
  • STUDY: A total of 543 patients (males, 362; females, 181) with gastric cancer were matched with 2 persons from the population without a diagnosis of gastric cancer as confirmed by endoscopy according to age (+/-2 y), sex, date of colonoscopy examination (+/-2 wk), and endoscopist.
  • RESULTS: A significantly higher colorectal cancer prevalence was found in the gastric cancer group, that is, 19 of 543 (3.5%) versus 14 of 1086 (1.3%; P<0.001).
  • The odds of developing colorectal cancer were higher in the presence of gastric cancer (odds ratios, 3.46; 95% confidence interval: 1.51-7.91).
  • Four of the 119 (3.4%) gastric cancer patients below 50 years of age had colorectal cancer in contrast with no cases in the matched controls.
  • The prevalence of colorectal adenoma was higher in the gastric cancer group, with a prevalence of 215 in 543 (39.6%) versus 311 in 1086 (28.6%; P<0.001).
  • The risk of adenoma was also greater among gastric cancer patients (odds ratios, 1.76; 95% confidence interval: 1.34-2.25).
  • CONCLUSIONS: Our data reveal a higher prevalence and risk of colorectal cancer in patients diagnosed with gastric cancer, particularly in patients below 50 years of age.
  • Additional studies are needed to explore the geographical differences in the association between gastric cancer and colon cancer.
  • [MeSH-major] Adenoma / epidemiology. Colorectal Neoplasms / epidemiology. Stomach Neoplasms / pathology

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  • (PMID = 19561531.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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51. Sargan I, Motoc A, Vaida MA, Bolintineanu S: Benign gastric tumors. Anatomopathological aspects of the gastric wall. Rev Med Chir Soc Med Nat Iasi; 2007 Oct-Dec;111(4):996-1000
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  • [Title] Benign gastric tumors. Anatomopathological aspects of the gastric wall.
  • Benign tumours of the stomach are quite rare and are discovered accidentally during routine endoscopy or necroscopy.
  • They represent less than 20 per cent of gastric tumours, and their clinical picture consists in pain, bleeding and antropyloric stenosis.
  • RESULTS: Benign tumoural pathology was present in 73 cases, 43 (58.9%) in women, 30 (42.1%) in men.
  • The material for study consisted in gastric resection pieces and specimens of needle biopsy.
  • In order to establish the histopathological diagnosis and to define the specific type of the damage, the first specimens were stained using morphological methods.
  • [MeSH-major] Biopsy, Needle. Precancerous Conditions / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Adult. Aged. Aged, 80 and over. Cardia / pathology. Diagnosis, Differential. Female. Hemangioma / pathology. Hospitals, General. Humans. Leiomyoma / pathology. Male. Middle Aged. Neurilemmoma / pathology. Polyps / pathology. Pyloric Antrum / pathology. Retrospective Studies. Treatment Outcome

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  • (PMID = 18389794.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Romania
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52. Kitoh T, Yanai H, Matsubara Y, Nakamura Y, Okamoto T, Hirano A, Yoshida T, Okita K: Endoscopic findings potentially predictive of gastric cancer in borderline lesions diagnosed by forceps biopsy. Hepatogastroenterology; 2005 Mar-Apr;52(62):404-8
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  • [Title] Endoscopic findings potentially predictive of gastric cancer in borderline lesions diagnosed by forceps biopsy.
  • BACKGROUND/AIMS: When a benign-malignant borderline lesion is diagnosed by the usual small gastric biopsy, there is sometimes difficulty in making a clinical decision.
  • To clarify potentially useful findings to predict the existence of gastric cancer in borderline lesions diagnosed by forceps biopsy, we retrospectively analyzed endoscopic features.
  • METHODOLOGY: We diagnosed 68 consecutive gastric benign-malignant borderline lesions (57 cases) by forceps biopsy and endoscopically resected them.
  • The final diagnosis for 24 lesions (35.3%) was adenocarcinoma (adenocarcinoma group), and for 40 lesions (58.8%) was adenoma (adenoma group).
  • RESULTS: We found six endoscopic findings (distal location, reddish surface color, lack of smoothness, lack of glossiness, focal roughness, and focal redness) having statistically significant relationships with adenocarcinoma at the final pathological diagnosis.
  • In multivariate analysis, focal redness (p<0.01) and lack of glossiness (p<0.05) were found to have a significant relationship to gastric cancer.
  • CONCLUSIONS: Endoscopic findings such as focal redness and lack of glossiness were potentially predictive of gastric cancer in borderline lesions diagnosed by forceps biopsy.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Biopsy / methods. Gastroscopy. Stomach Neoplasms / pathology. Surgical Instruments

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  • (PMID = 15816445.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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53. Jarus K, Braclik M: [Early gastric carcinoma--a case report: removal of gastric polyp in a 50-year-old man]. Pol Arch Med Wewn; 2007 Nov-Dec;117(11-12):521-3
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  • [Title] [Early gastric carcinoma--a case report: removal of gastric polyp in a 50-year-old man].
  • Early gastric cancer is one of the most often neoplasma.
  • The most of incidence of gastric cancer occur after 50 year of life.
  • Poland is a country with high morbidity of gastric cancer in Europe.
  • Two polyps in the stomach were revealed during the examination.
  • In conclusions, polyps, especially adenoma, should be removed shortly after diagnosis.
  • [MeSH-major] Polyps / surgery. Stomach Neoplasms / surgery

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  • (PMID = 18363252.001).
  • [Journal-full-title] Polskie Archiwum Medycyny Wewnetrznej
  • [ISO-abbreviation] Pol. Arch. Med. Wewn.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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54. Vieth M, Kushima R, de Jonge JP, Borchard F, Oellig F, Stolte M: Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum. Virchows Arch; 2005 May;446(5):542-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum.
  • In a 46-year-old man, a pedunculated rectal polyp measuring 3.0x3.0x2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa.
  • The luminal site was covered by glands of the gastric foveolar type, displaying focal marked proliferation interpreted as low-grade intraepithelial neoplasia.
  • A bidirectional gastric differentiation was found: most lower glandular structures showed positivity for the deep gastric mucin core protein Muc 6 and superficial positivity for gastric foveolar epithelium mucin core protein Muc 5AC.
  • Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb.
  • The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.
  • [MeSH-major] Adenoma / pathology. Choristoma. Gastric Mucosa. Intestinal Polyps / pathology. Rectal Neoplasms / pathology
  • [MeSH-minor] Cell Division. Humans. Intestinal Mucosa / pathology. Male. Middle Aged. Mucin 5AC. Mucin-6. Mucins / analysis. Stomach Neoplasms / chemistry. Stomach Neoplasms / pathology

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  • (PMID = 15838648.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6; 0 / Mucins
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55. Thomas D, Alexandraki K, Nikolaou A, Antoniou S, Kanakis G, Zilos A, Sougioultzis S, Kaltsas G: Primary hyperparathyroidism in patients with gastric carcinoid tumors type 1: an unusual coexistence. Neuroendocrinology; 2010;92(4):252-8
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  • [Title] Primary hyperparathyroidism in patients with gastric carcinoid tumors type 1: an unusual coexistence.
  • The aim of this study is to investigate the prevalence of PHP in our group of patients with gastric carcinoid (GC) type 1 tumors.
  • The diagnosis of PHP was suspected following elevated or high-normal serum calcium levels and elevated or inappropriate normal parathyroid hormone levels.
  • Four control groups were also studied: two age- and sex-matched groups of individuals with (n = 49) and without (n = 34) thyroid autoimmunity and normal endoscopy of the stomach, a third group with nongastric neuroendocrine tumors (n = 68), and a fourth group with atrophic gastritis and hypergastrinemia, without gastric endocrine tumors (n = 30).
  • Three of the 4 patients with PHP were operated and proved to have a parathyroid adenoma.
  • [MeSH-major] Carcinoid Tumor / complications. Hyperparathyroidism, Primary / complications. Stomach Neoplasms / complications
  • [MeSH-minor] Adenoma / complications. Adenoma / epidemiology. Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Humans. Incidence. Male. Middle Aged. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / epidemiology. Retrospective Studies. Young Adult


56. Li WB, Zuo XL, Zuo F, Gu XM, Yu T, Zhao YA, Zhang TG, Zhang JP, Li YQ: Characterization and identification of gastric hyperplastic polyps and adenomas by confocal laser endomicroscopy. Surg Endosc; 2010 Mar;24(3):517-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization and identification of gastric hyperplastic polyps and adenomas by confocal laser endomicroscopy.
  • BACKGROUND: Management of gastric polyps depends on their histologic composition.
  • A real-time in vivo histologic diagnosis would be valuable to an "on table" management decision.
  • This study aimed to assess the feasibility and practicability of using CLE to identify and differentiate gastric hyperplastic polyps and adenomas.
  • The CLE imaging of hyperplastic polyps and adenomas was performed, and the CLE diagnosis was compared with the gold standard of histopathologic diagnosis.
  • RESULTS: Imaging by CLE was successfully performed for 60 lesions of gastric hyperplastic polyps and 27 lesions of gastric adenomas.
  • Compared with the surrounding background mucosa, gastric hyperplastic polyps and adenomas showed typical distinct appearances, respectively, by CLE.
  • The overall accuracy of the in vivo CLE diagnosis of gastric hyperplastic polyps and adenomas during ongoing endoscopy was 90% (95% confidence interval [CI], 83-96%), and the overall accuracy of differentiating gastric hyperplastic polyps and adenomas by CLE was 97% (95% CI, 90-99%) after endoscopy.
  • CONCLUSIONS: This study characterized confocal images of gastric hyperplastic polyps and adenomas as well as the high accuracy of differentiating hyperplastic polyps and adenomas using CLE.
  • [MeSH-major] Adenoma / pathology. Gastric Mucosa / pathology. Microscopy, Confocal. Polyps / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Acriflavine. Adolescent. Adult. Aged. Aged, 80 and over. Confidence Intervals. Diagnosis, Differential. Female. Fluorescent Dyes. Gastroscopy. Humans. Male. Metaplasia / pathology. Middle Aged. Precancerous Conditions / pathology. Risk Factors

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  • (PMID = 19597774.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Fluorescent Dyes; 1T3A50395T / Acriflavine
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57. Jang CR, Choi SR, Cho JH, Koo YH, Han SH, Ryu SH, Lee DH, Jang JS, Lee JH, Roh MH, Cho JH: [A case of giant gastric villous tumor with carcinomatous change]. Korean J Gastroenterol; 2005 Jun;45(6):431-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of giant gastric villous tumor with carcinomatous change].
  • Villous tumors of the stomach are somewhat rare with approximately 100 cases only reported in the literatures and have tendency to undergo malignant transformation as high as 72%.
  • Thirty percent of them are associated with an independent gastric carcinoma.
  • Gastric villous tumor has certain radiologic characteristics that may permit a preoperative diagnosis and also some distinctive clinicopathologic features which make early diagnosis and proper treatment possible.
  • Esophagogastroduodenoscopy and barium study of upper gastrointestinal tract demonstrated typical, irregular, frond-like surfaced villous tumor occupying nearly whole gastric lumen and located eccentrically along the lesser curvature side.
  • Endoscopic biopsy of the tumor revealed a gastric villous tumor with carcinomatous change.
  • [MeSH-major] Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma, Villous / diagnostic imaging. Adenoma, Villous / pathology. Carcinoma / diagnostic imaging. Carcinoma / pathology. Humans. Male. Middle Aged. Radiography

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  • (PMID = 15973078.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
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58. Scatizzi M, Calistri M, Feroci F, Girardi LR, Moraldi L, Rubio CA, Moretti R, Nesi G: Gastric duplication cyst in an adult: case report. In Vivo; 2005 Nov-Dec;19(6):975-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric duplication cyst in an adult: case report.
  • Duplication cysts of the stomach are uncommon findings in adult patients and diagnosis is often overlooked.
  • We report a case of a non-communicating cyst of the stomach in a 67-year-old man.
  • [MeSH-major] Cysts / congenital. Cysts / pathology. Cysts / surgery. Stomach / abnormalities. Stomach Diseases / congenital. Stomach Diseases / surgery
  • [MeSH-minor] Adrenal Cortex Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis. Aged. Contrast Media / administration & dosage. Diagnosis, Differential. Follow-Up Studies. Gastrointestinal Stromal Tumors / diagnosis. Gastroscopy. Humans. Male. Stomach Neoplasms / diagnosis. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. X-Rays

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  • (PMID = 16277009.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Contrast Media
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59. Iwaki K, Shibata K, Ohta M, Endo Y, Uchida H, Tominaga M, Okunaga R, Kai S, Kitano S: Adenomyomatous hyperplasia of the common bile duct: report of a case. Surg Today; 2008;38(1):85-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomyomatous hyperplasia is most commonly found in the stomach, gallbladder, duodenum, and jejunum, while it is rarely found in the extrahepatic bile duct.
  • A 62-year-old woman was referred to our institution with a diagnosis of common bile duct (CBD) stenosis which had been detected by endoscopic retrograde cholangiopancreatography (ERCP).
  • When a diagnosis of adenomyomatous hyperplasia of the CBD is difficult to make both preoperatively and intraoperatively, then a radical surgical procedure, such as a pancreatoduodenectomy, may be an effective treatment alternative.
  • [MeSH-major] Adenoma / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Hyperplasia. Middle Aged. Pancreaticoduodenectomy / methods. Tomography, X-Ray Computed

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  • (PMID = 18085373.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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60. Ruggieri F, Chiesa A, Schorn K, Strobel K, Maggiorini M, Schmid C: Vanishing polyuria and respiratory failure. BMJ Case Rep; 2010;2010

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ectopic calcification was found in the lungs, in the thyroid, kidneys, heart and stomach.
  • A large parathyroid adenoma was then removed.
  • [MeSH-major] Adenoma / diagnosis. Hypercalcemia / etiology. Multiple Organ Failure / etiology. Parathyroid Neoplasms / diagnosis. Polyuria / etiology. Respiratory Distress Syndrome, Adult / etiology

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  • (PMID = 22791497.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028080
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61. Yoshida T, Kawachi H, Sasajima K, Shiokawa A, Kudo SE: The clinical meaning of a nonstructural pattern in early gastric cancer on magnifying endoscopy. Gastrointest Endosc; 2005 Jul;62(1):48-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical meaning of a nonstructural pattern in early gastric cancer on magnifying endoscopy.
  • Since en bloc EMR was developed, differentiation between mucosal and submucosal cancer is a critical issue in the management of gastric cancer.
  • Compared with histologic findings, the clinical meaning of the presence of a nonstructural pattern on the gastric neoplastic lesion was evaluated.
  • CONCLUSIONS: The presence of a nonstructural pattern appeared to be a useful marker to not proceed with EMR of gastric cancer.
  • [MeSH-major] Adenoma / pathology. Gastroscopy / methods. Image Enhancement. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Gastric Mucosa / pathology. Gastric Mucosa / surgery. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 15990819.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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62. Wheeler YY, Stoll LM, Sheth S, Li QK: Metastatic signet ring cell carcinoma presenting as a thyroid nodule: report of a case with fine-needle aspiration cytology. Diagn Cytopathol; 2010 Aug;38(8):597-602
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Herein, we report a case of metastatic gastric signet ring cell carcinoma to the thyroid.
  • These cytological features may be seen in cases of papillary thyroid carcinoma or signet ring cell follicular adenoma; however, the presence of the signet ring cells is unusual in primary thyroid lesions and raises the possibility of a metastatic lesion to the thyroid.
  • The patient was also found to have a 3.7-cm mass in the distal esophagus/proximal stomach.
  • The purpose of our study is to discuss the cytological features and the differential diagnosis of this unusual thyroid FNA case.
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Humans. Immunohistochemistry. Male. Stomach Neoplasms / pathology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 20014306.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Lisovsky M, Dresser K, Baker S, Fisher A, Woda B, Banner B, Lauwers GY: Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol; 2009 Jul;22(7):977-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study.
  • The diagnosis of gastric epithelial dysplasia, a precursor lesion of gastric adenocarcinoma, is hindered by interobserver variability and by its resemblance to regenerative changes.
  • Loss of cell polarity, a histological feature of gastric epithelial dysplasia, may be difficult to ascertain, especially in the setting of inflammation or injury.
  • A biomarker of cell polarity could be useful in diagnosis of dysplasia, but has not been reported.
  • Two homologs, lgl1 and lgl2, are present in mammals and lgl2 mRNA is highly expressed in the stomach.
  • The goal of our study was to test the hypothesis that Lgl2 protein expression and/or localization are disrupted in gastric epithelial dysplasia and adenocarcinoma.
  • Routinely processed pathology specimens including 94 benign mucosae of digestive organs, in addition to 36 reactive gastropathy, 57 gastric epithelial dysplasia, and 77 gastric adenocarcinomas, were immunostained for Lgl2 protein.
  • All normal, reactive, and chronically inflamed gastric epithelia showed basolateral Lgl2 staining.
  • Normal esophageal, duodenal, colonic, biliary, and pancreatic duct mucosae, as well as gastric intestinal metaplasia, did not express Lgl2.
  • All but one case each of gastric epithelial dysplasia and adenocarcinoma showed either complete loss of anti-Lgl2 immunoreactivity or diffuse, mostly weak, cytoplasmic staining.
  • Our data suggest that Lgl2 expression is either aberrantly localized or lost in gastric epithelial dysplasia and adenocarcinoma, whereas it is maintained in reactive gastric mucosa.
  • We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Cytoskeletal Proteins / metabolism. Gastric Mucosa / metabolism. Precancerous Conditions / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Cell Polarity. Female. Fluorescent Antibody Technique, Direct. Humans. Immunoenzyme Techniques. Male. Middle Aged. Young Adult

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  • (PMID = 19407852.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Hugl-2 protein, human
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64. Yao T: [Clinicopathological features of small intestinal tumors]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1436-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The prognosis of small intestinal cancer is poor, because preoperative diagnosis is difficult and it is usually discovered at the advanced stage.
  • In addition, it is thought that there are few small intestinal cancers of an adenoma origin, but dysplasia is considered to be associated with that complicated by Crohn's disease.
  • Among malignant lymphomas of the small intestine, the incidence of MALT lymphoma is lower, and those of T cell and follicular ones are higher than in the stomach.
  • Lymphomas with minimal cellular atypia are often encountered, and in such cases biopsy diagnosis is difficult.
  • The prognosis of malignant small intestinal disease will improve through early diagnosis with the recent progress in the procedures for detecting small intestinal disease.

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  • (PMID = 20716865.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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65. Chung HW, Kim JW, Lee JH, Song SY, Chung JB, Kwon OH, Lim JB: Comparison of the validity of three biomarkers for gastric cancer screening: carcinoembryonic antigen, pepsinogens, and high sensitive C-reactive protein. J Clin Gastroenterol; 2009 Jan;43(1):19-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of the validity of three biomarkers for gastric cancer screening: carcinoembryonic antigen, pepsinogens, and high sensitive C-reactive protein.
  • PURPOSE: To identify a desirable serum marker for screening tools for gastric cancer, we evaluated the validity of 3 biomarkers, namely, carcinoembryonic antigen (CEA), pepsinogens (PGs), and high sensitive C-reactive protein (hsCRP).
  • METHODS: We estimated the mean serum levels of CEA, PGs, and hsCRP and compared the sensitivity and specificity of these 3 biomarkers in 378 subjects who were classified into 7 groups: normal, chronic atrophic gastritis, intestinal metaplasia, adenoma, early gastric cancer (EGC), advanced gastric cancer (AGC) without metastasis, and AGC with metastasis (M1).
  • RESULTS: There were no significant differences among the normal, high-risk (chronic atrophic gastritis, intestinal metaplasia, and adenoma), and EGC groups for CEA and hsCRP.
  • CONCLUSIONS: The combination of serum hsCRP and PG I/II ratio would be helpful as a screening tool for gastric cancer in high incidence populations and may help to select high-risk subjects in need of further specific invasive screening tools such as endoscopy.
  • [MeSH-major] C-Reactive Protein / metabolism. Carcinoembryonic Antigen / blood. Pepsinogens / blood. Stomach Neoplasms / diagnosis

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  • (PMID = 18648315.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Carcinoembryonic Antigen; 0 / Pepsinogens; 9007-41-4 / C-Reactive Protein
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66. Joo MK, Park JJ, Lee WW, Lee BJ, Hwang JK, Kim SH, Jung W, Kim JH, Yeon JE, Kim JS, Byun KS, Bak YT: Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals. Endoscopy; 2010 Feb;42(2):114-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differences in the prevalence of colorectal polyps in patients undergoing endoscopic removal of gastric adenoma or early gastric cancer and in healthy individuals.
  • BACKGROUND AND AIMS: We compared the prevalence of adenomatous and cancerous colon polyps in patients who underwent endoscopic removal of gastric neoplasms and in healthy controls.
  • MATERIALS AND METHODS: This retrospective study reviewed the medical records of 186 patients with gastric neoplasms and 186 healthy subjects from January 2002 to October 2008.
  • The gastric neoplasm group was comprised of patients undergoing endoscopic removal of gastric adenomas or early gastric cancers and serial fiberoptic colonoscopy (FCS) for checkups.
  • The control group was comprised of subjects undergoing fiberoptic esophagogastroduodenoscopy (FEGD) and FCS for general checkup and was matched for age and sex with the gastric neoplasm group.
  • The overall prevalence of adenomatous or cancerous polyps ("all polyps") and the prevalence of advanced colonic neoplasms were significantly higher in the gastric neoplasm group than in the control group (all polyps: 40.9 % in the gastric neoplasm group vs. 25.8 % in the control group, P = 0.002; advanced colonic neoplasms: 15.6 % vs. 8.1 %, P = 0.025).
  • The risk factors for all polyps were age, male sex, diabetes mellitus, and being assigned to the gastric neoplasm group, and those for advanced colonic neoplasms were age and being assigned to the gastric neoplasm group.
  • Confining the analysis to the gastric neoplasm group, the risk factors for all polyps were identical with those for the total group; however, those for advanced colonic neoplasm were different (age vs. diabetes and hypertriglyceridemia).
  • CONCLUSION: Endoscopists should consider performing routine FCS in patients undergoing endoscopic removal of gastric neoplasms.
  • [MeSH-major] Adenoma / surgery. Colonic Polyps / epidemiology. Gastrectomy / methods. Gastroscopy / methods. Stomach Neoplasms / surgery

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20140828.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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67. Araki A, Shinohara M, Yamakawa J, Tanaka M, Natsui S, Izumi Y: Gastric diverticulum preoperatively diagnosed as one of two left adrenal adenomas. Int J Urol; 2006 Jan;13(1):64-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric diverticulum preoperatively diagnosed as one of two left adrenal adenomas.
  • Continued surgical exploration detected another mass between the spleen and the stomach, which was demonstrated to be continuous with the stomach and was eventually diagnosed as a gastric diverticulum.
  • [MeSH-major] Adrenocortical Adenoma / diagnosis. Diverticulum, Stomach / diagnosis. Preoperative Care
  • [MeSH-minor] Adrenalectomy / methods. Diagnosis, Differential. Humans. Hyperaldosteronism / diagnosis. Hyperaldosteronism / etiology. Laparoscopy. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16448434.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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68. Scoazec JY: [Dysplasia in glandular digestive tissues: new concepts, new classifications]. Ann Pathol; 2007 Dec;27(6):398-416

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  • The pathologist bears the full responsibility for the diagnosis of dysplasia, based on a broad spectrum of cytological and architectural abnormalities.
  • [MeSH-minor] Adenoma / pathology. Diagnosis, Differential. Disease Progression. Esophageal Neoplasms / pathology. Humans. Neoplasm Staging. Stomach Neoplasms / pathology

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  • (PMID = 18554550.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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69. Mohan H, Garg S, Punia RP, Dalal A: Combined serous cystadenoma and pancreatic endocrine neoplasm. A case report with a brief review of the literature. JOP; 2007;8(4):453-7
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  • This mass went beyond the stomach and above the lesser curvature of the stomach.
  • The diagnosis of combined microcystic adenoma and pancreatic endocrine neoplasm was made.
  • The coexistence of pancreatic endocrine neoplasms with potential malignant behavior may be overshadowed by obvious benign tumors such as a microcystic serous cystadenoma.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / complications. Cystadenoma, Serous / complications. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / complications

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  • (PMID = 17625299.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 13
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70. Kamisawa T, Tu Y, Egawa N, Nakajima H, Tsuruta K, Okamoto A: Malignancies associated with intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol; 2005 Sep 28;11(36):5688-90
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  • Histological diagnosis was confirmed in 30 cases (adenoma (n = 19) and adenocarcinoma (n = 11).
  • They were found before (n = 15), at (n = 19) and after (n = 6) the diagnosis of IPMT.
  • Major associated malignancies were gastric cancer (n = 12), colonic cancer (n = 7), esophageal cancer (n = 4), pulmonary cancer (n = 4), and independent pancreatic cancer (n = 3).
  • Pancreatic cancer was synchronous with IPMN in two patients and metachronous in one (3 years after diagnosis of IPMN).
  • CONCLUSION: IPMN is associated with a high incidence of other malignancies, particularly gastric and colonic cancers.
  • [MeSH-major] Adenocarcinoma, Mucinous / complications. Carcinoma, Pancreatic Ductal / complications. Colonic Neoplasms / complications. Esophageal Neoplasms / complications. Lung Neoplasms / complications. Stomach Neoplasms / complications

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  • (PMID = 16237766.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4481489
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71. Jun DW, Lee OY, Lim HC, Kwon SJ, Lee HL, Yoon BC, Choi HS, Hahm JS, Lee MH, Lee DH: Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer. World J Gastroenterol; 2007 Mar 21;13(11):1646-51
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  • [Title] Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer.
  • AIM: To examine the diagnostic yield of colorectal neoplasia at computed tomographic colonoscopy (CTC) as well as the feasibility of contrast enhanced CTC in patients with gastric cancer.
  • METHODS: To examine the incidence of colon polyp we selected postoperative 188 gastric cancer patients, which we refer to as the 'colon polyp survey group'.
  • To examine the feasibility of CTC for early detection of colon cancer or advanced colon adenoma, we selected 47 gastric cancer patients (M:F 29:18, mean age 53.8 years), which we call the 'CT colonoscopy group'.
  • RESULTS: Totally 109 colon polyps were observed from 59 out of 188 gastric cancer patients, the incidence rate of colon polyps in gastric cancer patients being 31.4%.
  • CONCLUSION: The diagnostic yield of colorectal polyp was 31.4% in patients with gastric cancer, and contrast enhanced CTC is an acceptable tool for the detection of synchronous colorectal advanced adenoma and postoperative surveillance of gastric cancer patients.
  • [MeSH-major] Adenoma / diagnosis. Colonic Polyps / diagnosis. Colonography, Computed Tomographic / methods. Colorectal Neoplasms / diagnosis. Stomach Neoplasms / surgery

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  • (PMID = 17461465.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4146941
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72. Wu CP, Jiang JT, Tan M, Zhu YB, Ji M, Xu KF, Zhao JM, Zhang GB, Zhang XG: Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis. World J Gastroenterol; 2006 Jan 21;12(3):457-9
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  • [Title] Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis.
  • AIM: To investigate the expression of co-stimulatory molecule B7-H3 in gastric carcinoma and adenoma tissue as well as normal gastric tissue and to explore the relationship between B7-H3 expression and pathological features and prognosis of gastric carcinoma.
  • METHODS: B7-H3 expression was detected in 102 samples of human gastric carcinoma and 10 samples of gastric adenoma and 10 samples of normal gastric tissue by immunohistochemical assay.
  • Correlation between the expression of B7-H3 and the patients' age, sex, gastric carcinoma locus, tumor size, tissue type, tumor infiltration depth, differentiation degree, lymph node metastasis, and survival time was analyzed.
  • RESULTS: B7-H3 was expressed in all gastric adenoma samples and in 58.8% samples of gastric carcinoma.
  • B7-H3 expression in gastric carcinoma samples was not related with the patients' age, sex, lymph node metastasis, and tumor size (P>0.05), but with the survival time, infiltration depth of tumor and tissue type.
  • CONCLUSION: Detection of B7-H3 expression in gastric carcinoma tissue is beneficial to the judgment of the prognosis of gastric carcinoma patients and the choice of treatment.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Antigens, CD. Antigens, CD80 / metabolism. B7 Antigens. Gastric Mucosa / cytology. Gastric Mucosa / metabolism. Humans. Immunohistochemistry. Prognosis. Receptors, Immunologic. Retrospective Studies. Survival Rate

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  • (PMID = 16489649.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD80; 0 / B7 Antigens; 0 / CD276 protein, human; 0 / Receptors, Immunologic
  • [Other-IDs] NLM/ PMC4066068
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73. Zurac S, Micu G, Bastian A, Grămadă E, Lavric L, Andrei R, Stăniceanu F, Voiosu R, Croitoru A: Malignancy and overdiagnosis of malignancy in Peutz Jeghers polyposis. Rom J Intern Med; 2008;46(2):179-84
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  • Despite their benign nature there is a certain increased risk of progression to malignancy in some cases, justifying a sustained follow-up of the patients.
  • Two of these cases were related (mother and daughter); both of them were operated in another hospital for small bowel tumors with a subsequent diagnosis of adenocarcinoma.
  • The daughter (28 years old) was referred to our hospital for endoscopic follow-up; a small polyp of the transverse large bowel was excised by colonoscopy with a histopathologic diagnosis of PJ polyp; a careful histopathologic reevaluation of both specimens of enterectomy (slides and paraffin blocks) revealed an overdiagnosis of cancer due to the epithelial cystic dilatation and pseudoinvasion in both patients.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Intestinal Neoplasms / pathology. Intestinal Polyps / pathology. Peutz-Jeghers Syndrome / diagnosis. Stomach Neoplasms / pathology

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  • (PMID = 19284092.001).
  • [ISSN] 1220-4749
  • [Journal-full-title] Romanian journal of internal medicine = Revue roumaine de médecine interne
  • [ISO-abbreviation] Rom J Intern Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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74. Saito S, Hosoya Y, Togashi K, Kurashina K, Haruta H, Hyodo M, Koinuma K, Horie H, Yasuda Y, Nagai H: Prevalence of synchronous colorectal neoplasms detected by colonoscopy in patients with gastric cancer. Surg Today; 2008;38(1):20-5
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  • [Title] Prevalence of synchronous colorectal neoplasms detected by colonoscopy in patients with gastric cancer.
  • PURPOSE: Our purpose was to study the characteristics of colorectal neoplasms in patients with gastric cancer (GC).
  • Synchronous colorectal adenoma and cancer were detected in 182 (39%) and 18 (4%) patients, respectively.
  • [MeSH-major] Colonoscopy / methods. Colorectal Neoplasms / epidemiology. Neoplasms, Multiple Primary / epidemiology. Stomach Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Japan / epidemiology. Male. Middle Aged. Neoplasm Staging / methods. Prevalence. Retrospective Studies. Risk Factors

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  • (PMID = 18085357.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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75. Aretz S, Uhlhaas S, Goergens H, Siberg K, Vogel M, Pagenstecher C, Mangold E, Caspari R, Propping P, Friedl W: MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype. Int J Cancer; 2006 Aug 15;119(4):807-14

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  • To determine the frequency, mutation spectrum and phenotype of the recently described autosomal recessive MUTYH-associated polyposis (MAP), we performed a systematic search for MUTYH (MYH) mutations by sequencing the complete coding region of the gene in 329 unselected APC mutation-negative index patients with the clinical diagnosis of familial adenomatous polyposis (FAP) or attenuated FAP (AFAP).
  • Fifty percentage of the MAP patients had colorectal cancer at diagnosis.
  • Duodenal polyposis was found in 18%, thyroid and stomach cancer in 1 case, other extraintestinal manifestations associated with FAP were not observed.
  • [MeSH-minor] Adenoma / genetics. Adolescent. Adult. Aged. Child. Child, Preschool. Colorectal Neoplasms / genetics. Humans. Middle Aged. Phenotype

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16557584.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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76. Iakovidis DK, Maroulis DE, Karkanis SA: An intelligent system for automatic detection of gastrointestinal adenomas in video endoscopy. Comput Biol Med; 2006 Oct;36(10):1084-103
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  • [MeSH-major] Adenoma / diagnosis. Artificial Intelligence. Colonic Polyps / diagnosis. Diagnosis, Computer-Assisted / instrumentation. Endoscopes, Gastrointestinal. Image Processing, Computer-Assisted / methods. Polyps / diagnosis. Stomach Neoplasms / diagnosis. Video Recording / instrumentation

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  • (PMID = 16293240.001).
  • [ISSN] 0010-4825
  • [Journal-full-title] Computers in biology and medicine
  • [ISO-abbreviation] Comput. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Sung HY, Cheung DY, Cho SH, Kim JI, Park SH, Han JY, Park GS, Kim JK, Chung IS: Polyps in the gastrointestinal tract: discrepancy between endoscopic forceps biopsies and resected specimens. Eur J Gastroenterol Hepatol; 2009 Feb;21(2):190-5
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  • The aim of this prospective study was to determine the diagnostic concordance between an EFB and resected tissues of gastric and colon polyps.
  • One thousand two hundred and sixty-four polyps of epithelial origin [gastric polyps (n=268) and colon polyps (n=996)] obtained from 813 patients met the inclusion criteria.
  • The pathological diagnoses of resected gastric polyps were as follows: adenomas with low-grade dysplasia, 46 (17.2%); adenomas with high-grade dysplasia, 42 (15.7%); hyperplastic polyps, 126 (47.0%); chronic inflammatory polyps, 29 (10.8%); and adenocarcinomas, 25 (9.3%).
  • The discrepancy rate between an EFB and the pathology of the resected gastric polyps was 39.2% (the Kendall's tau-b and the kappa coefficient for agreement between the EFB and resected specimens of gastric polyps were 0.577 and 0.472, respectively; P value <0.001).
  • No relationship between the size of the gastric polyp and the concordance rate was observed.
  • Therefore, complete removal of the entire polyp is recommended to confirm the diagnosis, to remove precancerous lesions, and to develop an optimal management plan.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / pathology. Adenoma / surgery. Aged. Biopsy. Colonic Polyps / pathology. Colonic Polyps / surgery. Endoscopy, Gastrointestinal. Female. Humans. Male. Middle Aged. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Prospective Studies. Reproducibility of Results. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 19092673.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Hotta K, Oyama T, Akamatsu T, Tomori A, Hasebe O, Nakamura N, Kojima E, Suga T, Miyabayashi H, Ohta H: A comparison of outcomes of endoscopic submucosal dissection (ESD) For early gastric neoplasms between high-volume and low-volume centers: multi-center retrospective questionnaire study conducted by the Nagano ESD Study Group. Intern Med; 2010;49(4):253-9
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  • [Title] A comparison of outcomes of endoscopic submucosal dissection (ESD) For early gastric neoplasms between high-volume and low-volume centers: multi-center retrospective questionnaire study conducted by the Nagano ESD Study Group.
  • OBJECTIVE: Outcomes of endoscopic submucosal dissection (ESD) for early gastric neoplasms at low-volume centers have been unknown, because all previous reports have studied in advanced single centers.
  • Early gastric cancer (EGC) was divided into three categories on the basis of pathological diagnosis-standard indication (SI), expanded indication (EI) and out-of-indication (OI).
  • RESULTS: A total of 703 early gastric neoplasms (586 EGCs, 117 gastric adenomas) were treated with ESD from January to December 2005.
  • CONCLUSION: There were no significant difference in the outcomes of ESD for early gastric neoplasms between high- and low volume centers.
  • [MeSH-major] Endoscopy, Gastrointestinal. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adenoma / surgery. Dissection. Gastric Mucosa / surgery. Humans. Japan. Postoperative Complications / etiology. Retrospective Studies. Surveys and Questionnaires. Treatment Outcome

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  • [CommentIn] Intern Med. 2010;49(4):251-2 [20154427.001]
  • (PMID = 20154428.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Japan
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79. Tajima Y, Yamazaki K, Makino R, Nishino N, Aoki S, Kato M, Morohara K, Kaetsu T, Kusano M: Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background. Clin Cancer Res; 2006 Nov 1;12(21):6469-79
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  • [Title] Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background.
  • PURPOSE: Gastric and intestinal phenotypic cell markers are expressed in gastric carcinomas, irrespective of their histologic type.
  • In the present study, we determined the clinicopathologic significance of phenotypic marker expression in early-stage gastric differentiated-type tumors and the association between marker expression and genetic alterations.
  • EXPERIMENTAL DESIGN: Phenotypic marker expression was determined by examining the expressions of human gastric mucin (HGM), MUC6, MUC2, and CD10 in 63 gastric adenomas, 133 early differentiated-type carcinomas, and 24 follow-up cases with gastric adenoma.
  • Tumors were classified into gastric, gastric and intestinal mixed, or intestinal phenotypes according to the immunopositivity of the above markers.
  • RESULTS: The expressions of HGM and MUC6, representing gastric or gastric and intestinal mixed phenotypes, were significantly associated with high-grade atypia in the 63 gastric adenomas.
  • A multivariate analysis revealed that gastric adenomas were significantly associated with the intestinal phenotype and were inversely associated with p53 mutation compared with early differentiated-type carcinomas.
  • Malignant transformation from gastric adenoma to carcinoma was shown in 5 of the 24 follow-up cases of gastric adenoma.
  • The malignant transformation was significantly associated with the gastric and intestinal mixed phenotype and was inversely associated with APC mutation.
  • No malignant transformation was found in intestinal phenotype gastric adenomas with APC mutation.
  • CONCLUSIONS: Our present findings show that phenotypic marker expression is associated with tumor aggressiveness during the early stage of gastric differentiated-type tumors.
  • Differences in the biological behavior of tumors with different phenotypes may result from differences in the genetic backgrounds during the incipient phase of gastric tumorigenesis.
  • [MeSH-major] Adenoma / genetics. Adenoma / metabolism. Biomarkers, Tumor / genetics. Stomach Neoplasms / genetics. Stomach Neoplasms / metabolism
  • [MeSH-minor] DNA Mutational Analysis. Gastric Mucins / biosynthesis. Genes, APC. Genes, p53. Genes, ras. Humans. Immunohistochemistry. Microsatellite Instability. Microsatellite Repeats. Mucin-2. Mucin-6. Mucins / biosynthesis. Mutation. Neprilysin / biosynthesis. Phenotype. Polymerase Chain Reaction

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  • (PMID = 17085661.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Gastric Mucins; 0 / MUC2 protein, human; 0 / MUC6 protein, human; 0 / Mucin-2; 0 / Mucin-6; 0 / Mucins; EC 3.4.24.11 / Neprilysin
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80. Takasu N, Kimura W, Moriya T, Takeshita A, Murayama S, Hirai I, Ogata S: A pancreatobiliary-type carcinoma in situ at the periphery of a mural nodule developed from a gastric adenoma in an intraductal papillary mucinous neoplasm. Clin J Gastroenterol; 2010 Aug;3(4):209-13
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  • [Title] A pancreatobiliary-type carcinoma in situ at the periphery of a mural nodule developed from a gastric adenoma in an intraductal papillary mucinous neoplasm.
  • We report a rare case of an intraductal papillary mucinous neoplasm (IPMN) with a pancreatobiliary-type carcinoma in situ (CIS) that originated around a mural nodule formed in a gastric-type adenoma.
  • Histopathologic examination showed an intraductal papillary mucinous carcinoma arising from an adenoma.
  • Hematoxylin and eosin (H&E) staining revealed that most of the tumor components, including the mural nodule, had adenomatous changes, indicating the tumor to be of the gastric type; however, immunohistochemistry showed positive MUC2 expression.

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  • (PMID = 26190249.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Growth pattern / Intraductal papillary mucinous neoplasm / Mural nodule / Subtype
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81. Baba Y, Iyama K, Ikeda K, Ishikawa S, Hayashi N, Miyanari N, Honda Y, Sado Y, Ninomiya Y, Baba H: Differential expression of basement membrane type IV collagen alpha chains in gastric intramucosal neoplastic lesions. J Gastroenterol; 2007 Nov;42(11):874-80
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  • [Title] Differential expression of basement membrane type IV collagen alpha chains in gastric intramucosal neoplastic lesions.
  • BACKGROUND: The histological diagnosis of gastric intramucosal neoplastic lesions (GINLs) is controversial among experienced pathologists.
  • We examined the immunohistochemical expression of alpha(IV) chains in GINLs and investigated whether the expression pattern was a diagnostic marker of gastric intramucosal carcinoma.
  • RESULTS: In normal gastric epithelium, alpha1(IV), alpha2(IV), alpha5(IV), and alpha6(IV) chains were expressed continuously in the BM.
  • CONCLUSIONS: The loss of alpha5/alpha6(IV) chains might be a useful diagnostic finding for gastric intramucosal carcinoma in GINL cases.
  • [MeSH-major] Adenocarcinoma / metabolism. Basement Membrane / metabolism. Collagen Type IV / metabolism. Gastric Mucosa / metabolism. Stomach Neoplasms / metabolism
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Epithelium / metabolism. Epithelium / pathology. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism

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  • (PMID = 18008031.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Collagen Type IV; 0 / Ki-67 Antigen
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82. Yoshida S, Tanaka S, Hirata M, Mouri R, Kaneko I, Oka S, Yoshihara M, Chayama K: Optical biopsy of GI lesions by reflectance-type laser-scanning confocal microscopy. Gastrointest Endosc; 2007 Jul;66(1):144-9
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  • Twenty-two areas of 15 untreated specimens from the esophagus (normal mucosa, n=1; dysplasia, n=1), stomach (normal mucosa, n=3; cancer, n=5), and colon (normal mucosa, n=3; adenoma, n=8; cancer, n=1) were examined.
  • Irregular nuclei were visualized in 3 of 5 gastric-cancer specimens and in cells around the crypt of the colonic-cancer specimen.
  • Nuclei were visualized in 5 of 8 colonic-adenoma specimens.
  • Nuclei were not visualized in 2 of 3 normal gastric-mucosa specimens or in normal colonic-mucosa specimens.
  • CONCLUSIONS: LCM provides instant microscopic images, and, with further technical improvement, in the future this novel method will aid in immediate diagnosis under endoscopy without the need for tissue biopsy.
  • [MeSH-major] Adenocarcinoma / pathology. Barrett Esophagus / pathology. Biopsy / methods. Colonic Neoplasms / pathology. Microscopy, Confocal. Stomach Neoplasms / pathology

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  • [CommentIn] Gastrointest Endosc. 2007 Jul;66(1):150-3 [17591489.001]
  • (PMID = 17591488.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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83. Kato M, Kaise M, Yonezawa J, Yoshida Y, Tajiri H: Autofluorescence endoscopy versus conventional white light endoscopy for the detection of superficial gastric neoplasia: a prospective comparative study. Endoscopy; 2007 Nov;39(11):937-41
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  • [Title] Autofluorescence endoscopy versus conventional white light endoscopy for the detection of superficial gastric neoplasia: a prospective comparative study.
  • BACKGROUND AND STUDY AIMS: Preliminary studies have suggested autofluorescence endoscopy (AFE) to be accurate in the diagnosis of gastric tumors.
  • Our prospective blinded study systematically compared AFE with white light endoscopy (WLE) for the detection of superficial gastric neoplasia.
  • PATIENTS AND METHODS: An enriched population included 33 patients with superficial gastric neoplasia referred for endoscopic submucosal dissection (ESD), and 18 control patients undergoing follow-up endoscopy after curative ESD.
  • RESULTS: 39 gastric neoplasias were histologically confirmed and 52 non-neoplastic lesions were found to be either WLE- and/or AFE-positive.
  • CONCLUSIONS: Although one quarter of elevated gastric neoplasias were detected only by AFE, its specificity is poor; therefore its clinical value is limited.
  • [MeSH-major] Gastroscopes. Gastroscopy / methods. Stomach Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Biopsy, Needle. Carcinoma / pathology. Carcinoma / surgery. Case-Control Studies. False Negative Reactions. False Positive Reactions. Female. Fluorescence. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Probability. Prospective Studies. Sensitivity and Specificity

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  • [CommentIn] Endoscopy. 2007 Nov;39(11):1021-2 [18008209.001]
  • (PMID = 18008201.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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84. Kim SG, Song HJ, Choi IJ, Cho JY, Jung HY, Keum B, Cheon JH, Lee YC, Kim JG, Park SK, Park BJ, Jung HC, Korean College of Helicobacter and Upper Gastrointestinal Research: A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm. Gut Liver; 2010 Dec;4(4):514-7

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  • [Title] A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm.
  • BACKGROUND/AIMS: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm.
  • METHODS: We intend to enroll up to 232 patients H.-pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection.

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  • (PMID = 21253301.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3021608
  • [Keywords] NOTNLM ; Endoscopic resection / Eradication / Helicobacter pylori / Iatrogenic ulcer / Medical Research Collaboration Center
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85. Sanada Y, Oue N, Mitani Y, Yoshida K, Nakayama H, Yasui W: Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype. J Pathol; 2006 Apr;208(5):633-42
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  • [Title] Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype.
  • Gastric cancer (GC) is one of the most common malignancies worldwide.
  • Immunostaining showed that normal gastric mucosa and Paneth cells of the duodenum expressed claudin-18 on cell membranes.
  • Expression of claudin-18 was reduced in several intestinal metaplasias of the stomach.
  • Of 20 samples of gastric adenoma, 18 (90.0%) showed decreased claudin-18 expression.
  • In addition, expression of the gastric and intestinal phenotypes of GC was examined by immunostaining for MUC5AC, MUC6, MUC2, and CD10.
  • Down-regulation of claudin-18 may be involved in GCs with an intestinal phenotype, and may be an early event in gastric carcinogenesis.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / biosynthesis. Down-Regulation. Membrane Proteins / biosynthesis. Stomach Neoplasms / metabolism
  • [MeSH-minor] Claudins. Duodenum / metabolism. Gastric Mucosa / metabolism. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. Neoplasm Proteins / biosynthesis. Neoplasm Proteins / genetics. Neoplasm Staging. Phenotype. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods. Survival Analysis. Tumor Cells, Cultured

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  • (PMID = 16435283.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CLDN18 protein, human; 0 / Claudins; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm
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86. Szalóki T, Tóth V, Tiszlavicz L, Czakó L: Flat gastric polyps: results of forceps biopsy, endoscopic mucosal resection, and long-term follow-up. Scand J Gastroenterol; 2006 Sep;41(9):1105-9
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  • [Title] Flat gastric polyps: results of forceps biopsy, endoscopic mucosal resection, and long-term follow-up.
  • OBJECTIVE: Histological examination of specimens obtained by forceps biopsy sampling of gastric polyps is of limited accuracy, and their management on this basis is therefore controversial.
  • The aim of this prospective study was to assess the value of forceps biopsy sampling in establishing the correct diagnosis revealed by endoscopic mucosal resection (EMR).
  • MATERIAL AND METHODS: Subjects with gastric polyps of epithelial origin, of at least 0.5 cm in diameter, and not associated with polyposis syndromes, were included in the study.
  • Between 1994 and 2004, 56 gastric polyps in 44 patients (30 F, 14 M, mean age 67 years) met the inclusion criteria.
  • RESULTS: The initial forceps biopsies identified in situ carcinoma in 3 cases, adenoma with no dysplasia in 19, adenoma with low-grade dysplasia in 2, adenoma with moderate-grade dysplasia in 6, adenoma with high-grade dysplasia in 7, and hyperplastic lesions in 19 cases.
  • The histological examination of the resected polyps revealed in situ carcinoma in 5 cases, carcinoid in 1, gastrointestinal stromal tumor in 1, adenoma with no dysplasia in 14, adenoma with low-grade dysplasia in 3, adenoma with moderate-grade dysplasia in 9, adenoma with high-grade dysplasia in 1, hyperplastic lesions in 21, and no diagnosis in 1 case.
  • CONCLUSIONS: Forceps biopsy is not sufficiently reliable for the identification of gastric polyps.
  • These lesions should be fully resected by EMR for a final diagnosis and (depending on the lesion size and type) possibly definitive treatment.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Polyps / pathology. Polyps / surgery. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Gastric Mucosa / surgery. Gastric Mucosa / ultrastructure. Humans. Male. Microscopy, Electron. Middle Aged. Prospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 16938725.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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87. Sohn VY, Arthurs ZM, Martin MJ, Sebesta JA, Branch JB, Champeaux AL: Incidental pathologic findings in open resectional gastric bypass specimens with routine cholecystectomy and appendectomy. Surg Obes Relat Dis; 2008 Sep-Oct;4(5):608-11
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  • [Title] Incidental pathologic findings in open resectional gastric bypass specimens with routine cholecystectomy and appendectomy.
  • Although various procedures exist, one of the procedures offered at our institution is resectional Roux-en-Y gastric bypass with incidental cholecystectomy and appendectomy.
  • This procedure allows for pathologic assessment of otherwise normal viscera routinely removed as a part of the gastric bypass.
  • The purpose of this study was to determine the incidence of abnormal findings of the extirpated, gallbladder, appendix, and distal stomach after gastric bypass surgery.
  • In the gastric remnant, the reported pathologic findings included chronic or active gastritis in 66, fundic gland polyps in 7, intestinal metaplasia in 3, gastric ulcers in 2, gastropathy in 2, lymphoid aggregate in 1, diverticulum in 1, a developmental cyst in 1, and leiomyoma in 1.
  • Other resected findings included five Meckel's diverticula, one bile duct adenoma, and one sigmoid diverticulum.
  • [MeSH-major] Appendectomy / methods. Cecal Diseases / diagnosis. Cholecystectomy / methods. Gallbladder Neoplasms / diagnosis. Gastric Bypass / methods. Incidental Findings. Stomach Diseases / diagnosis
  • [MeSH-minor] Adenomyoma / complications. Adenomyoma / diagnosis. Adenomyoma / surgery. Adolescent. Adult. Aged. Cholelithiasis / complications. Cholelithiasis / diagnosis. Cholelithiasis / surgery. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Obesity / complications. Obesity / surgery. Retrospective Studies. Young Adult

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  • (PMID = 18586563.001).
  • [ISSN] 1550-7289
  • [Journal-full-title] Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
  • [ISO-abbreviation] Surg Obes Relat Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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88. Park JY, Cornish TC, Lam-Himlin D, Shi C, Montgomery E: Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am J Surg Pathol; 2010 Nov;34(11):1591-8
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  • [Title] Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting.
  • We investigated the frequency of PGAs and other lesions in all nonconsultation gastric biopsies and resections (1988 to 2008) diagnosed as AMAG.
  • We further selected cases confirmed as AMAG by immunohistochemical identification of the gastric body (negative gastrin) and linear and nodular enterochromaffin-like cell hyperplasia (chromogranin).
  • We identified a total of 41,245 patients with gastric biopsies or resections from 46.7% males and 53.3% females comprising patients self-identified as 67.0% white, 23.6% African-American, 1.4% Asian, 0.8% non-White Hispanic, and 7.2% other or unknown.
  • These lesions (n=240) consisted of 179 polyps (138 hyperplastic polyps, 20 oxyntic mucosa pseudopolyps, 18 intestinal-type gastric adenomas, and 3 PGAs), 46 well-differentiated neuroendocrine neoplasms (carcinoid), 1 gastrointestinal stromal tumor, 3 lymphomas, and 11 adenocarcinomas.
  • [MeSH-major] Adenoma / diagnosis. Autoimmune Diseases / diagnosis. Gastritis, Atrophic / diagnosis. Polyps / diagnosis. Precancerous Conditions / diagnosis. Stomach / pathology. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Baltimore. Biopsy. Chromogranins / analysis. Female. Gastrectomy. Gastric Mucosa / pathology. Gastrins / analysis. Humans. Immunohistochemistry. Male. Metaplasia. Middle Aged

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  • [CommentIn] Am J Surg Pathol. 2011 Aug;35(8):1244; author reply 1244-5 [21753703.001]
  • (PMID = 20975338.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromogranins; 0 / Gastrins
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89. Uchida M, Tsukamoto Y, Uchida T, Ishikawa Y, Nagai T, Hijiya N, Nguyen LT, Nakada C, Kuroda A, Okimoto T, Kodama M, Murakami K, Noguchi T, Matsuura K, Tanigawa M, Seto M, Ito H, Fujioka T, Takeuchi I, Moriyama M: Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization. J Pathol; 2010 May;221(1):96-105
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  • [Title] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization.
  • Although genomic copy number aberrations (CNAs) of gastric carcinoma at the advanced stage have already been extensively characterized by array comparative genomic hybridization (array CGH) analysis, those of gastric carcinoma in situ (CIS) are still poorly understood.
  • Furthermore, no reports have demonstrated correlations between CNAs and histopathological features of gastric adenoma.
  • In this study, we investigated CNAs of 20 gastric CISs (Vienna category 4.2) and 20 adenomas including seven low-grade adenomas (LGA; Vienna category 3) and 13 high-grade adenomas (HGA; Vienna category 4.1), using oligonucleotide-based array CGH.
  • Since HGA is believed to have a higher risk of progression to invasive carcinoma than LGA, these data suggest that 8q gain is important for the malignant transformation of gastric adenoma.
  • [MeSH-major] Adenoma / genetics. Carcinoma in Situ / genetics. Stomach Neoplasms / genetics

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  • [Copyright] Copyright (c) 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 20217874.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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90. Brown SW, Vyas BV, Spiegel DR: Mania in a case of hyperparathyroidism. Psychosomatics; 2007 May-Jun;48(3):265-8
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  • [MeSH-major] Adenoma / diagnosis. Bipolar Disorder / complications. Hyperparathyroidism / complications. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Pain / complications. Anemia, Iron-Deficiency / complications. Anemia, Iron-Deficiency / therapy. Antipsychotic Agents / administration & dosage. Aripiprazole. Benzodiazepines / administration & dosage. Blood Transfusion. Calcium / blood. Diagnosis, Differential. Female. Hematocrit / methods. Hemoglobins. Humans. Hypercalcemia / complications. Hypercalcemia / psychology. Middle Aged. Nausea / complications. Parathyroid Hormone / analysis. Piperazines / administration & dosage. Psychomotor Agitation / complications. Psychomotor Agitation / psychology. Quinolones / administration & dosage. Stomach Ulcer / complications. Weight Loss

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  • (PMID = 17478597.001).
  • [ISSN] 0033-3182
  • [Journal-full-title] Psychosomatics
  • [ISO-abbreviation] Psychosomatics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antipsychotic Agents; 0 / Hemoglobins; 0 / Parathyroid Hormone; 0 / Piperazines; 0 / Quinolones; 12794-10-4 / Benzodiazepines; 132539-06-1 / olanzapine; 82VFR53I78 / Aripiprazole; SY7Q814VUP / Calcium
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91. Minematsu H, Saito Y, Kakinoki R, Andoh A, Kushima R, Fujiyama Y: Evaluation of mucin expression patterns in gastric borderline (group III) lesions. J Gastroenterol; 2006 Jun;41(6):547-53
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  • [Title] Evaluation of mucin expression patterns in gastric borderline (group III) lesions.
  • BACKGROUND: Recommendations for diagnosis and treatment of gastric borderline (group III) lesions remain controversial.
  • METHODS: Sixty-three gastric lesions were histopathologically identified as belonging to group III on the basis of an endoscopic forceps biopsy.
  • All of the patients underwent endoscopic resection, and the lesions were classified into group A (final diagnosis, adenocarcinoma) or group B (final diagnosis, adenoma).
  • RESULTS: The proportion of complete gastric (positive for MUC5AC and MUC6) plus gastric-predominant phenotypes was significantly higher in group A (58.0%) than in group B (18.7%) lesions (P < 0.05).
  • CONCLUSIONS: Immunostaining of forceps biopsy samples for the mucin phenotype may be helpful for diagnosing gastric borderline (group III) lesions.
  • [MeSH-major] Mucins / biosynthesis. Stomach Neoplasms / classification. Stomach Neoplasms / metabolism

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  • (PMID = 16868802.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Mucins
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92. Ogata M, Maejima K, Chihara N, Mizutani S, Komine O, Bo H, Shioya T, Watanabe M, Tokunaga A, Tajiri T: Successful use of endoscopic argon plasma coagulation for patients with early gastric cancer and diabetes mellitus. J Nippon Med Sch; 2007 Jun;74(3):246-50
Hazardous Substances Data Bank. Argon, Elemental .

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  • [Title] Successful use of endoscopic argon plasma coagulation for patients with early gastric cancer and diabetes mellitus.
  • We report on two patients with gastric tumors (early cancer and adema) and diabetes mellitus who were treated with argon plasma coagulation (APC) therapy. Case 1.
  • An early gastric cancer (IIc) in the anterior wall of the gastric antrum was diagnosed on the basis of the results of a gastric endoscopy examination.
  • A 61-year-old man was referred to our hospital because of a gastric tumor.
  • A gastric adenoma in the anterior of the gastric antrum was diagnosed on the basis of the results of a gastric endoscopy examination.
  • Endoscopic APC was performed in both patients to remove the gastric tumors.
  • APC therapy appears to be a safe and useful treatment for patients with diabetes and gastric mucosal lesions.
  • [MeSH-major] Diabetes Complications. Gastroscopy. Laser Coagulation / methods. Stomach Neoplasms / surgery
  • [MeSH-minor] Adenoma / surgery. Aged. Argon. Female. Humans. Male. Middle Aged

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  • (PMID = 17625375.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 67XQY1V3KH / Argon
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93. Vallot T: [Gastric polyps]. Presse Med; 2007 Oct;36(10 Pt 2):1412-7
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  • [Title] [Gastric polyps].
  • Gastric polyps exist in a wide variety of types, most often benign.
  • Endoscopic discovery of gastric polyps necessitates biopsies - not only of the lesion but also of the antral and fundic mucosa to determine the therapeutic strategy and subsequent surveillance.
  • These polyps are associated with an elevated frequency of precancerous alterations of the gastric mucosa and consequently by an elevated risk of synchronous or metachronous cancer.
  • Eradication of Helicobacter pylorus may reduce the risk of metachronous gastric cancer and recurrence after resection.
  • The advantages and procedures for endoscopic surveillance of patients with a precancerous condition of the gastric mucosa have not yet been clearly established in populations with a low incidence of cancer.
  • [MeSH-major] Adenocarcinoma. Adenoma. Carcinoid Tumor. Polyps. Precancerous Conditions. Stomach Diseases. Stomach Neoplasms
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Endoscopy. Helicobacter Infections / complications. Helicobacter Infections / prevention & control. Helicobacter pylori. Humans. Incidence. Lymphatic Metastasis. Neoplasm Metastasis. Prevalence. Risk Factors. Stomach / pathology

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  • (PMID = 17482791.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 35
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94. Bajbouj M, von Weyhern C, Becker V, Seidl S, Ott R, Schatke W, Fend F, Schmid RM, Meining A: True adenomas of the cardia: a case series of 3 patients. Digestion; 2008;77(1):65-7
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  • METHODS AND RESULTS: Three patients with polypoid masses at the cardia below the Z-line were submitted to a tertiary referral center for further diagnosis and therapy.
  • In 2 of the 3 cases the final histopathological diagnosis of low-grade adenoma of the cardia could only be established after complete removal of the polypoid masses.
  • CONCLUSIONS: Adenomas of the cardia can be mistaken for dysplasia arising from Barrett's esophagus, if the diagnosis is based on endoscopic biopsies only.
  • [MeSH-major] Adenomatous Polyps / pathology. Cardia / pathology. Stomach Neoplasms / pathology

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18349540.001).
  • [ISSN] 1421-9867
  • [Journal-full-title] Digestion
  • [ISO-abbreviation] Digestion
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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95. Karam SM, Tomasetto C, Rio MC: Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice. Cell Prolif; 2008 Dec;41(6):923-935
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  • [Title] Amplification and invasiveness of epithelial progenitors during gastric carcinogenesis in trefoil factor 1 knockout mice.
  • OBJECTIVE: It is not known whether or not epithelial progenitors of the pyloric antrum are involved in gastric carcinogenesis.
  • This study was designed to examine the changes that occur in pyloric antral mucous cell lineages and their progenitors during development of gastric adenoma and carcinoma in trefoil factor 1 (TFF1) knockout mice.
  • CONCLUSION: This study shows that the progenitors of pit and gland mucous cells contribute to gastric carcinogenesis in the pyloric antrum of TFF1 knockout mice, strongly supporting the concept of stem cell origin of cancer.
  • [MeSH-major] Epithelial Cells / pathology. Peptides / deficiency. Stem Cells / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aging / pathology. Animals. Cell Differentiation. Cell Division. Cell Lineage. Cell Proliferation. Gastric Mucosa / pathology. Gastric Mucosa / ultrastructure. Lectins / metabolism. Mice. Mice, Inbred C57BL. Mice, Knockout. Neoplasm Invasiveness. Pyloric Antrum / pathology. Pyloric Antrum / ultrastructure. Pylorus / pathology. Pylorus / ultrastructure. Trefoil Factor-1

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  • (PMID = 19040570.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lectins; 0 / Peptides; 0 / Tff1 protein, mouse; 0 / Trefoil Factor-1
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96. Tate G, Suzuki T, Endo Y, Mitsuya T: A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer. Cancer Genet Cytogenet; 2008 Jul;184(1):67-71
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  • In one patient, who suffered from bilateral breast cancer, thyroid adenoma, and gastric malignant lymphoma, we found a single-base substitution in exon 2 (115G>C) of the PTEN gene.
  • [MeSH-minor] Adenoma / complications. Adenoma / genetics. Base Sequence. DNA Primers. Female. Humans. Polymerase Chain Reaction. Thyroid Neoplasms / complications. Thyroid Neoplasms / genetics

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  • (PMID = 18558293.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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97. Jeong HK, Park CH, Jun CH, Lee GH, Kim HI, Kim HS, Choi SK, Rew JS: A prospective randomized trial of either famotidine or pantoprazole for the prevention of bleeding after endoscopic submucosal dissection. J Korean Med Sci; 2007 Dec;22(6):1055-9
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  • In a prospective trial, patients undergoing ESD due to gastric adenoma or adenocarcinoma were randomly assigned to pantoprazole or famotidine.
  • [MeSH-major] 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use. Anti-Ulcer Agents / therapeutic use. Famotidine / therapeutic use. Gastric Mucosa / surgery. Gastrointestinal Hemorrhage / prevention & control. Gastroscopy. Postoperative Hemorrhage / prevention & control. Stomach Neoplasms / surgery

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  • (PMID = 18162722.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / 2-Pyridinylmethylsulfinylbenzimidazoles; 0 / Anti-Ulcer Agents; 5QZO15J2Z8 / Famotidine; D8TST4O562 / pantoprazole
  • [Other-IDs] NLM/ PMC2694634
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98. Sun J, Xu K, Wu C, Wang Y, Hu Y, Zhu Y, Chen Y, Shi Q, Yu G, Zhang X: PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies. Tissue Antigens; 2007 Jan;69(1):19-27
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  • [Title] PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies.
  • Then, by using immunohistochemistry staining with monoclonal antibody 2H11, the expression of PD-L1 was found in human gastric carcinoma specimens but not in normal or gastric adenoma tissues.
  • Additional data show that PD-L1 can be regarded as a decisive factor in evaluating gastric carcinoma prognosis and anti-human PD-L1 monoclonal antibody 10E10 could inhibit T-cell apoptosis induced by tumor-associated PD-L1.
  • [MeSH-major] Antibodies, Blocking / physiology. Antibodies, Monoclonal / physiology. Antigens, CD / genetics. Antigens, CD / immunology. Carcinoma / metabolism. Signal Transduction / immunology. Stomach Neoplasms / metabolism

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  • (PMID = 17212704.001).
  • [ISSN] 0001-2815
  • [Journal-full-title] Tissue antigens
  • [ISO-abbreviation] Tissue Antigens
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Blocking; 0 / Antibodies, Monoclonal; 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human
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99. Buffart TE, Carvalho B, Mons T, Reis RM, Moutinho C, Silva P, van Grieken NC, Vieth M, Stolte M, van de Velde CJ, Schrock E, Matthaei A, Ylstra B, Carneiro F, Meijer GA: DNA copy number profiles of gastric cancer precursor lesions. BMC Genomics; 2007;8:345
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA copy number profiles of gastric cancer precursor lesions.
  • BACKGROUND: Chromosomal instability (CIN) is the most prevalent type of genomic instability in gastric tumours, but its role in malignant transformation of the gastric mucosa is still obscure.
  • In the present study, we set out to study whether two morphologically distinct categories of gastric cancer precursor lesions, i.e. intestinal-type and pyloric gland adenomas, would carry different patterns of DNA copy number changes, possibly reflecting distinct genetic pathways of gastric carcinogenesis in these two adenoma types.
  • The most frequent aberrations in intestinal-type gastric adenoma were gains on 11q, 9q and 8, and losses on chromosomes 5q, 6, 10 and 13, whereas in pyloric gland gastric adenomas these were gains on chromosome 20 and losses on 5q and 6.
  • However, no significant differences were observed between the two adenoma types.
  • CONCLUSION: The results suggest that gains on chromosomes 8, 9q, 11q and 20, and losses on chromosomes 5q, 6, 10 and 13, likely represent early events in gastric carcinogenesis.
  • [MeSH-major] DNA, Neoplasm / genetics. Precancerous Conditions / genetics. Stomach Neoplasms / genetics

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  • (PMID = 17908304.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2147033
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100. Matsuda A, Kato S, Furuya M, Shimizu Y, Okino T, Sasaki J, Tajiri T: Multiple early gastric cancer with duodenal invasion. World J Surg Oncol; 2007;5:125
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  • [Title] Multiple early gastric cancer with duodenal invasion.
  • BACKGROUND: Early gastric cancers with duodenal invasion are rare, and no previous case of multiple early gastric cancer, one invading the duodenal bulb, has been reported.
  • Biopsy revealed a tubular adenoma for the antrum lesion and a well-differentiated tubular adenocarcinoma for the prepyloric lesion.
  • CONCLUSION: Here, we present an unusual case of multiple early gastric cancer, one of which invaded the duodenum with relative wide mucosal spreading.
  • This case illustrates that even early stage cancers located in the gastric antrum, particularly in the prepyloric area can invade the duodenum directly.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Duodenal Neoplasms / secondary. Neoplasm Invasiveness / pathology. Neoplasms, Multiple Primary / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Aged. Biopsy, Needle. Female. Follow-Up Studies. Gastrectomy / methods. Humans. Immunohistochemistry. Laparotomy / methods. Neoplasm Staging. Risk Assessment. Treatment Outcome

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  • (PMID = 17971200.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2173897
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