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1. Swaroop Mr, Nischal Kc, Rajesh Gowda Cm, Umashankar Nu, Basavaraj Hb, Sathyanarayana Bd: Radiofrequency ablation of adenoma sebaceum. J Cutan Aesthet Surg; 2008 Jul;1(2):89-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiofrequency ablation of adenoma sebaceum.
  • Adenoma sebaceum is one of the diagnostic features of tuberous sclerosis.
  • Laser treatment is expensive and any form of treatment for adenoma sebaceum is not a one-time procedure but is a recurring process as the condition is genetic in aetiology.

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  • (PMID = 20300351.001).
  • [ISSN] 0974-5157
  • [Journal-full-title] Journal of cutaneous and aesthetic surgery
  • [ISO-abbreviation] J Cutan Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2840910
  • [Keywords] NOTNLM ; Adenoma sebaceum / disfigurement / radiofrequency / tuberous sclerosis
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2. de Vicente Rodríguez JC, Fresno Forcelledo MF, González García M, Aguilar Andrea C: Sebaceous adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal; 2006 Aug;11(5):E446-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous adenoma of the parotid gland.
  • The majority of salivary gland neoplasms are benign, with malignant salivary tumors accounting for 15 to 32 percent.
  • The most common site for salivary gland tumors is the parotid gland, accounting up to 80 percent of all cases.
  • This article reports the pathologic picture in a case of sebaceous adenoma of the parotid gland.
  • The tumor was composed of epithelial cells lining ducts and closely associated with broad areas of sebaceous differentiation.
  • The growth pattern was predominantly cystic, with cavities filled with sebaceous material.
  • The presence of sebaceous glands in salivary neoplasms is frequent, however, and in spite of this, salivary neoplasms constituted partially or entirely of these cells are rarely observed.
  • To the surgeon and pathologist, the major problem in dealing with sebaceous adenoma is the recognition of this rare entity, avoiding confusing with other more aggressive neoplasms.
  • The addition of the current case to the previously published data brings the total number of parotid sebaceous adenoma to seven.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16878064.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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3. Zare-Mahmoodabadi R, Salehinejad J, Saghafi S, Ghazi N, Mahmoudi P, Harraji A: Sebaceous adenoma of the submandibular gland: a case report. J Oral Sci; 2009 Dec;51(4):641-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous adenoma of the submandibular gland: a case report.
  • Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas.
  • Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures.
  • We describe a case of sebaceous adenoma in the submandibular gland.
  • Excisional biopsy resulted in a diagnosis of sebaceous adenoma.
  • [MeSH-major] Adenoma / pathology. Submandibular Gland Neoplasms / pathology

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  • (PMID = 20032620.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Ponti G, Losi L, Pedroni M, Lucci-Cordisco E, Di Gregorio C, Pellacani G, Seidenari S: Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas. J Invest Dermatol; 2006 Oct;126(10):2302-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of MLH1 and MSH2 mutations in the appearance of Muir-Torre syndrome phenotype in HNPCC patients presenting sebaceous gland tumors or keratoacanthomas.
  • A main clinical variant of Lynch syndrome, Muir-Torre syndrome (MTS) is characterized by the association between one or more visceral malignancies, with at least one sebaceous skin tumor or keratoacanthoma.
  • In our study, we have screened a cohort of 538 HNPCC patients, related to 57 HNPCC families, to detect sebaceous skin tumors and keratoacanthomas and the role of mismatch repair (MMR) genes, MLH1, MSH2, and MSH6, in their pathogenesis.
  • Among the 57 HNPCC families, we have identified four MTS families and one suspected MTS family, in which sebaceous carcinoma was found in one HNPCC mutation carrier subject who did not show visceral malignancy.
  • The evidences of our investigations show that MLH1 and MSH2 gene mutations have an equivalent etiopathological role both for Lynch syndrome and for MTS; hence, we propose a broadened clinical criteria for definition of Lynch syndrome that will include sebaceous adenoma, carcinoma, and keratoacanthoma.
  • [MeSH-major] Carrier Proteins / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Keratoacanthoma / genetics. MutS Homolog 2 Protein / genetics. Mutation. Nuclear Proteins / genetics. Sebaceous Gland Neoplasms / genetics

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  • [CommentIn] J Invest Dermatol. 2006 Oct;126(10):2158-9 [16983324.001]
  • (PMID = 16826164.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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5. Shen-Li H, Koujak S, Szablocs M, Parsons R: Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice. Cancer Biol Ther; 2010 Dec 1;10(11):1194-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly, and sebaceous adenomas.

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  • (PMID = 20980828.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA082783-08; United States / NCI NIH HHS / CA / CA082783-09; United States / NCI NIH HHS / CA / CA082783-07; United States / NCI NIH HHS / CA / R01 CA082783-07; United States / NCI NIH HHS / CA / CA082783-08; United States / NCI NIH HHS / CA / CA082783; United States / NCI NIH HHS / CA / R01 CA082783-09; United States / NCI NIH HHS / CA / R01 CA082783-06; United States / NCI NIH HHS / CA / R01 CA082783; United States / NCI NIH HHS / CA / CA082783-06
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Small Interfering; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS254407; NLM/ PMC3018670
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6. Cabrera Duro A, Rodrigo Carbonero D, Aramendi Gallardo J, Pastor Menchaca E, Galdeano Miranda JM, Hermana Tenzanos T, Prats Viñas JM: [Tuberous sclerosis associated with rhabdomyoma in the left ventricular outlet tract]. An Pediatr (Barc); 2005 Apr;62(4):367-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a 2-month old newborn with a family history of adenoma sebaceum, achromic spots and renal lithiasis.

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  • (PMID = 15826566.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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7. Olsen SH, Su LD, Thomas D, Fullen DR: Telomerase expression in sebaceous lesions of the skin. J Cutan Pathol; 2007 May;34(5):386-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Telomerase expression in sebaceous lesions of the skin.
  • BACKGROUND: Recent studies have demonstrated telomerase expression in ophthalmologic sebaceous carcinoma and have suggested possible diagnostic utility in distinguishing these neoplasms from sebaceous adenomas.
  • The aim of this study was to evaluate telomerase expression via human telomerase reverse transcriptase (hTERT) immunohistochemical staining in a spectrum of sebaceous lesions of the skin.
  • METHODS: Paraffin-embedded sections from sebaceous hyperplasia (11), nevus sebaceus (22), sebaceous adenoma (19), sebaceoma (11), and sebaceous carcinoma (14) were evaluated for intensity (0 to 3+) and pattern of anti-hTERT staining.
  • RESULTS: Strong (2 to 3+) hTERT staining was observed in nucleoli of germinative cells and immature sebocytes in all sebaceous lesions, whereas mature sebocytes were negative.
  • CONCLUSIONS: All hyperplastic and neoplastic sebaceous skin lesions expressed hTERT in this immunohistochemical study.
  • The pattern of staining was predictive of the histologic pattern of the process but does not significantly add to our diagnostic armamentarium of sebaceous lesions.
  • [MeSH-major] Sebaceous Gland Diseases / enzymology. Telomerase / biosynthesis

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  • (PMID = 17448193.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.7.49 / Telomerase
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8. Azevedo RS, Almeida OP, Netto JN, Miranda AM, Santos TC, Della Coletta R, Lopes MA, Pires FR: Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Jan;107(1):100-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma.
  • OBJECTIVE: The objective of this study was to compare the clinicopathological features of oral sebaceous hyperplasia and sebaceous adenoma.
  • STUDY DESIGN: Clinical data, microscopical characteristics, and ki-67 immunoexpression were comparatively analyzed on 2 intraoral sebaceous adenomas, 6 intraoral sebaceous hyperplasias, and 21 normal intraoral sebaceous glands.
  • RESULTS: Clinically, sebaceous glands presented as multiple separated papules, sebaceous hyperplasias as a single enlarged papule, and sebaceous adenoma as a well-defined nodule.
  • Microscopically, sebaceous adenoma presented an increased number of lobules, smaller lobules, and a greater number of germinative/squamous cells.
  • Sebaceous hyperplasia also had an increased number of lobules and fewer number of germinative/squamous cells, as compared to normal oral sebaceous glands.
  • Ki-67 expression was seen only in germinative cells and counts were higher in sebaceous adenomas followed by hyperplasias and normal glands.
  • CONCLUSIONS: Sebaceous hyperplasias and adenomas showed different clinical, microscopic, and proliferative characteristics, suggesting the usefulness of the studied criteria on diagnosis of these uncommon oral lesions.
  • [MeSH-major] Adenoma / pathology. Mouth Neoplasms / pathology. Sebaceous Gland Diseases / pathology. Sebaceous Gland Neoplasms / pathology. Sebaceous Glands / pathology

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  • (PMID = 19101492.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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9. El-Musa KA, Shehadi RS, Shehadi S: Extensive facial adenoma sebaceum: successful treatment with mechanical dermabrasion: case report. Br J Plast Surg; 2005 Dec;58(8):1143-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extensive facial adenoma sebaceum: successful treatment with mechanical dermabrasion: case report.
  • This report documents the successful elimination of disfiguring sebaceous adenomas from the face of a 21-year-old male patient with mechanical dermabrasion.
  • [MeSH-major] Adenoma / surgery. Dermabrasion / methods. Facial Neoplasms / surgery. Sebaceous Gland Neoplasms / surgery

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  • (PMID = 16061214.001).
  • [ISSN] 0007-1226
  • [Journal-full-title] British journal of plastic surgery
  • [ISO-abbreviation] Br J Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. Dhingra KK, Saroha V, Gupta P, Khurana N: Demodex-associated dermatologic conditions--A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma. Pathol Res Pract; 2009;205(6):423-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Demodex-associated dermatologic conditions--A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma.
  • Demodex folliculorum is a saprophytic mite of the human pilosebaceous unit with a prelidiction for facial skin and eyelashes.
  • Skin lesions, such as rosacea, pityriasis, and blepharitis, have been attributed to Demodex; however, its role in sebaceous adenoma (SA) has not been reported in extensively searched medical literature.
  • We report this rare case and review the skin lesions associated with Demodex folliculorum.
  • [MeSH-major] Adenoma / microbiology. Mite Infestations / complications. Sebaceous Gland Neoplasms / microbiology. Skin Diseases / microbiology

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  • (PMID = 19167837.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Insecticides; 509F88P9SZ / Permethrin
  • [Number-of-references] 18
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11. Apple SK, Moatamed NA, Lai CK, Bhuta S: Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. Acta Cytol; 2009 Jul-Aug;53(4):419-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation.
  • BACKGROUND: Sebaceous adenoma of the salivary gland is an extremely rare, benign neoplasm that predominantly involves the major salivary glands.
  • The major problem in dealing with sebaceous adenoma is the recognition of this entity to avoid confusion with other more aggressive neoplasms, such as mucoepidenmoid carcinoma.
  • The major problem in dealing with sebaceous adenoma is the recognition ofthis entity in cytologic specimens to avoid confusion with other more aggressive neoplasms such as low grade mucoepidermoid carcinoma and potentially to avoid radical surgery.
  • [MeSH-major] Adenoma / pathology. Biopsy, Fine-Needle. Parotid Neoplasms / pathology

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  • (PMID = 19697727.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Ajith Kumar VK, Gold JA, Mallon E, Thomas S, Hodgson SV: Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin. Fam Cancer; 2008;7(2):187-9
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  • [Title] Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin.
  • Muir Torre Syndrome is the association of internal malignancies with sebaceous gland tumours; Lynch Syndrome/Hereditary Non Polyposis Cancer is the best known cause.
  • There has been a previous report of sebaceous gland tumours in an Italian patient with MYH associated polyposis.
  • We describe a man of Indian (Gujarati) descent who has MYH associated polyposis and multiple sebaceous adenomas of the skin.
  • [MeSH-major] Adenoma / genetics. Adenomatous Polyposis Coli / genetics. DNA Glycosylases / genetics. Sebaceous Gland Neoplasms / genetics

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  • (PMID = 17874208.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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13. Sakuma T, Ueno C, Kawano K: [Sebaceous adenoma of caruncula lacrimalis: report of two cases]. Klin Monbl Augenheilkd; 2009 May;226(5):432-3
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  • [Title] [Sebaceous adenoma of caruncula lacrimalis: report of two cases].
  • [Transliterated title] Adenoma Sebaceum der Caruncula Lacrimalis: Bericht über zwei Fälle.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Adenocarcinoma, Sebaceous / therapy. Lacrimal Apparatus Diseases / pathology. Lacrimal Apparatus Diseases / therapy. Sebaceous Gland Neoplasms / pathology. Sebaceous Gland Neoplasms / therapy

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  • (PMID = 19507089.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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14. Kiratli H, Poyraz C, Gököz A: Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia. Cornea; 2007 Oct;26(9):1136-7
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  • [Title] Sebaceous adenoma of the bulbar conjunctiva in association with glioblastoma multiforme and chronic lymphocytic leukemia.
  • PURPOSE: To describe a patient with a sebaceous adenoma of the bulbar conjunctiva, a distinctly unusual site for this tumor, associated with glioblastoma multiforme and chronic lymphocytic leukemia.
  • RESULTS: Histopathologic examination of the tumor showed a sebaceous adenoma.
  • CONCLUSIONS: Sebaceous adenoma is an exceedingly rare tumor of the bulbar conjunctiva and may be associated with several systemic malignancies.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Brain Neoplasms / pathology. Conjunctival Neoplasms / pathology. Glioblastoma / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 17893552.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Cabral ES, Auerbach A, Killian JK, Barrett TL, Cassarino DS: Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry. Am J Dermatopathol; 2006 Dec;28(6):465-71
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  • [Title] Distinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry.
  • Sebaceous lesions, including sebaceous hyperplasia, sebaceomas, and sebaceous adenomas and carcinomas, are histologically distinctive adnexal proliferations with a spectrum of biological behavior ranging from benign to frankly malignant.
  • The histologic distinction between sebaceous adenomas and carcinomas may be challenging, especially in cases showing atypical features and in small or partial biopsies.
  • We studied multiple oncogenic and therapeutic related proteins by immunohistochemistry to identify differences in expression between benign and malignant sebaceous proliferations.
  • A total of 27 cases, including 9 sebaceous adenomas, 4 sebaceomas, 8 sebaceous carcinomas, and 6 cases of sebaceous hyperplasia, were examined by immunohistochemistry, with antibodies directed against Ki-67 (MIB-1), bcl-2, p53, p21WAF1, p27Kip1, c-erbB-2 (Her-2/neu), CD117 (c-kit), cyclin D1, MDM2, CD99, MLH-1, and MSH-2.
  • We found that sebaceous adenomas and sebaceomas stained like sebaceous hyperplasia did, whereas carcinomas had statistically significantly increased levels of p53 (50% versus 11%, respectively) and Ki-67 (30% versus 10%).
  • The carcinomas also had significantly reduced levels of bcl-2 (7% versus 56%, respectively) and p21 (16% versus 34%) compared to the adenomas.
  • In addition, we found little or no Her-2/neu and CD117 staining, indicating that immunotherapy with Herceptin or Gleevac would likely not be useful for sebaceous carcinomas.
  • Moreover, these results show that sebaceous adenomas and carcinomas are distinct neoplasms and provide no support for the theory that all sebaceous adenomas are truly malignant.
  • [MeSH-major] Biomarkers, Tumor / analysis. Facial Neoplasms / chemistry. Sebaceous Gland Neoplasms / chemistry. Sebaceous Glands / chemistry
  • [MeSH-minor] Adenocarcinoma, Sebaceous / chemistry. Adenoma / chemistry. Adult. Aged. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p21 / analysis. Female. Humans. Hyperplasia. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptor, ErbB-2 / analysis. Tumor Suppressor Protein p53 / analysis


16. Smrkovski OA, LeBlanc AK, Smith SH, LeBlanc CJ, Adams WH, Tobias KM: Carcinoma ex pleomorphic adenoma with sebaceous differentiation in the mandibular salivary gland of a dog. Vet Pathol; 2006 May;43(3):374-7
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  • [Title] Carcinoma ex pleomorphic adenoma with sebaceous differentiation in the mandibular salivary gland of a dog.
  • A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog.
  • On surgical exploration, the mass was intimately associated with the left mandibular salivary gland.
  • Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology.
  • Salivary gland tumors with sebaceous differentiation are very rare in animals, with one previously reported case in a cat.
  • [MeSH-major] Adenoma, Pleomorphic / veterinary. Carcinoma / veterinary. Dog Diseases / diagnosis. Salivary Gland Neoplasms / veterinary

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  • (PMID = 16672588.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Li B, Li N, Cheng G, Sun X, Xu X, Shi J, Li L, Chen C: Correlation of the expression of telomerase RNA with risk factors for recurrence of sebaceous gland carcinoma. Graefes Arch Clin Exp Ophthalmol; 2006 Apr;244(4):480-4
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  • [Title] Correlation of the expression of telomerase RNA with risk factors for recurrence of sebaceous gland carcinoma.
  • AIMS: To investigate the expression of human telomerase gene RNA (hTR) and human telomerase reverse transcriptase (hTRT) in eyelid sebaceous gland carcinoma and to evaluate risk factors for sebaceous carcinoma recurrence.
  • METHODS: The expression patterns of hTR and hTRT were detected by in situ hybridization (ISH) in paraffin-embedded samples of 55 eyelid sebaceous gland carcinoma, 12 chalazia, and four sebaceous adenoma.
  • The proliferation index (PI) of sebaceous gland carcinoma was determined by Ki-67 immunolabeling and the results were compared with the expression of hTR and hTRT.
  • Several factors for recurrence of sebaceous gland carcinoma were evaluated by statistical analysis.
  • RESULTS: Expression of hTR and hTRT was present mainly in the sebaceous gland carcinoma tissues and not in adjacent tissues of carcinoma, chalazia, and sebaceous adenoma.
  • The prevalence of hTR, hTRT, and Ki-67 expression in 55 sebaceous carcinoma samples were 84.45%, 58.1%, and 78.18%, respectively. hTR expression was highly associated with the degree of carcinoma differentiation (P<0.001) and hTRT expression was correlated with the proliferation index as determined by Ki-67 staining (P<0.005).
  • There was a correlation between the recurrence of sebaceous gland carcinoma and the patient's onset age (OR=0.914, P<0.05), as well as the time to first treatment (OR=1.163, P<0.01).
  • CONCLUSIONS: Telomerase may play an important role in the carcinogenesis of sebaceous gland carcinoma, and expression of hTR and hTRT combined with other features of sebaceous gland carcinoma may be helpful for the diagnosis and evaluation of clinical prognosis.
  • Risk factors for recurrence of sebaceous gland carcinoma are patients' onset age and the time to first treatment.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Eyelid Neoplasms / metabolism. Neoplasm Recurrence, Local / metabolism. RNA, Untranslated / metabolism. Sebaceous Gland Neoplasms / metabolism. Telomerase / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Female. Gene Expression / physiology. Humans. Immunoenzyme Techniques. In Situ Hybridization. Ki-67 Antigen / metabolism. Male. Middle Aged. RNA. RNA, Long Noncoding. Risk Factors

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  • (PMID = 16133023.001).
  • [ISSN] 0721-832X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / RNA, Long Noncoding; 0 / RNA, Untranslated; 0 / telomerase RNA; 63231-63-0 / RNA; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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18. Heyl J, Mehregan D: Immunolabeling pattern of cytokeratin 19 expression may distinguish sebaceous tumors from basal cell carcinomas. J Cutan Pathol; 2008 Jan;35(1):40-5
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  • [Title] Immunolabeling pattern of cytokeratin 19 expression may distinguish sebaceous tumors from basal cell carcinomas.
  • BACKGROUND: Distinction between sebaceous tumors and basal cell carcinomas can often pose diagnostic problems.
  • Our aim was to evaluate the use of CK 19 staining patterns in differentiating between sebaceous tumors and basal cell carcinomas.
  • The sebaceous tumors that were examined in this study included sebaceous adenomas, sebaceous epitheliomas (sebaceomas) and sebaceous carcinomas.
  • METHODS: Thirty-seven cases including 5 sebaceous adenomas, 16 sebaceous epitheliomas, 6 sebaceous carcinomas and 14 basal cell carcinomas (7 being of the morpheaform type and 7 nodular basal cell carcinomas) were tested with a monoclonal mouse antibody to human CK 19.
  • RESULTS: CK 19 was focally positive in 1/5 (20%) sebaceous adenomas, 8/16 (50%) of sebaceous epitheliomas and 1/6 (17%) of sebaceous carcinomas.
  • Strongly positive expression of CK 19 was not seen in any of the sebaceous adenoma, sebaceous epithelioma or sebaceous carcinoma specimens.
  • CONCLUSION: CK 19 expression can be helpful in differentiating sebaceous tumors (including sebaceous adenomas, sebaceous epitheliomas and sebaceous carcinomas) from basal cell carcinomas and may be a useful adjunct when these entities are included in the differential diagnosis.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Adenoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Keratin-19 / analysis. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Glands / pathology

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  • (PMID = 18095993.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19
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19. Prabhu S, Mahesh KP: Tuberous sclerosis with oral angiofibroma: case report. Br J Oral Maxillofac Surg; 2010 Apr;48(3):205-7
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  • We present a patient who presented with facial angiofibromas (adenoma sebaceum), shagreen patches, and epileptic seizures.
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Male. Skin Neoplasms / pathology

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  • [Copyright] 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19640621.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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20. Calder KB, Khalil FK, Schlauder S, Cualing HD, Morgan MB: Immunohistochemical expression of survivin in cutaneous sebaceous lesions. Am J Dermatopathol; 2008 Dec;30(6):545-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of survivin in cutaneous sebaceous lesions.
  • To date, there are no studies evaluating the expression of survivin in sebaceous neoplasms.
  • METHODS: Immunohistochemical expression of survivin was evaluated in a total of 20 extraocular sebaceous neoplasms: sebaceous hyperplasia (SH, 8), sebaceous adenoma (SA, 8), and sebaceous carcinoma (SC, 4).
  • These findings demonstrate the potential diagnostic utility of survivin, further assisting in the microscopic differentiation of benign and malignant sebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Adenoma / metabolism. Microtubule-Associated Proteins / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Sebaceous Glands / pathology

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  • (PMID = 19033926.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins
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21. Halsey MA, Calder KB, Mathew R, Schlauder S, Morgan MB: Expression of alpha-methylacyl-CoA racemase (P504S) in sebaceous neoplasms. J Cutan Pathol; 2010 Apr;37(4):446-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of alpha-methylacyl-CoA racemase (P504S) in sebaceous neoplasms.
  • Despite the importance of lipid metabolism in sebum production by sebaceous glands of the skin, there are no studies evaluating the expression of AMACR in sebaceous neoplasms.
  • METHODS: Five samples of normal sebaceous glands as well as five cases each of sebaceous hyperplasia (SH), sebaceous adenoma (SA), basal cell carcinoma (BCC) with sebaceous differentiation and extraocular sebaceous carcinoma (SC) were evaluated for immunohistochemical (IHC) expression of AMACR.
  • RESULTS: Normal sebaceous glands showed strong (4+) expression of AMACR.
  • Among sebaceous neoplasms, SH showed the highest expression (4+), SA and BCC with sebaceous differentiation showed varied expression (2+ and 1+, respectively), and extraocular SC showed no expression of AMACR.
  • CONCLUSIONS: The expression of AMACR is increased in benign sebaceous glands and SH; with decreasing AMACR expression in tumors with less sebaceous differentiation (i.e.
  • SA and SC). These findings provide insight into the potential pathogenesis of sebaceous neoplasms while assisting in the microscopic distinction of SA from SC.
  • [MeSH-major] Adenoma / enzymology. Carcinoma / enzymology. Racemases and Epimerases / metabolism. Sebaceous Gland Neoplasms / enzymology. Sebaceous Glands / enzymology

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  • (PMID = 19638170.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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22. Eisen DB, Michael DJ: Sebaceous lesions and their associated syndromes: part I. J Am Acad Dermatol; 2009 Oct;61(4):549-60; quiz 561-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous lesions and their associated syndromes: part I.
  • Sebaceous neoplasms have long been a source of confusion to dermatologists and pathologists alike.
  • Sebaceous lesions represent a broad spectrum of interesting entities that range from hamartomas, hyperplasias, and benign tumors to highly malignant neoplasms.
  • This article discusses the clinical and pathologic features of sebaceous hyperplasia, nevus sebaceous of Jadassohn, sebaceous adenoma, seboacanthoma, sebaceous epithelioma, sebaceoma, mantleoma, basal cell carcinoma with sebaceous differentiation, sebomatricoma (sebomatrixoma), and sebaceous carcinoma.
  • [MeSH-major] Sebaceous Gland Diseases / classification. Sebaceous Gland Diseases / pathology. Sebaceous Gland Neoplasms / classification. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 19751879.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 145
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23. Ponti G, Ponz de Leon M: Muir-Torre syndrome. Lancet Oncol; 2005 Dec;6(12):980-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Muir-Torre syndrome is an autosomal-dominant skin condition of genetic origin, characterised by tumours of the sebaceous gland or keratoacanthoma that are associated with visceral malignant diseases.
  • The cutaneous characteristics of Muir-Torre syndrome are sebaceous adenoma, epithelioma, carcinoma, or multiple keratoacanthomas, whereas visceral malignant diseases include colorectal, endometrial, urological, and upper gastrointestinal tumours.
  • Diagnosis of these rare sebaceous lesions warrants the search for associated internal malignant diseases: the peculiarity of skin lesions and their biomolecular characterisation with microsatellite instability analysis and immunohistochemistry could be used to identify familial Muir-Torre syndrome, allowing clinicians to tailor a personalised programme to screen for skin and visceral malignant diseases in high-risk individuals.
  • [MeSH-major] DNA Repair. Keratoacanthoma / genetics. Keratoacanthoma / pathology. Sebaceous Gland Neoplasms / genetics. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16321766.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 66
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24. Olubunmi OA: Misdiagnosis of tuberous sclerosis in a Nigerian girl: a case report and review of literature. Ann Afr Med; 2010 Apr-Jun;9(2):95-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis is a rare neuro-cutaneous syndrome, one of the phakomatosis, characterized by facial angiofibromas (adenoma sebaceum), mental retardation and epilepsy.
  • [MeSH-minor] Adolescent. Angiofibroma / diagnosis. Anticonvulsants / therapeutic use. Diagnostic Errors. Epilepsy / drug therapy. Epilepsy / etiology. Female. Humans. Intellectual Disability / etiology. Neurofibromatoses / diagnosis. Skin Neoplasms / diagnosis. Tomography, X-Ray Computed. Treatment Outcome. Valproic Acid / therapeutic use

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  • (PMID = 20587932.001).
  • [ISSN] 0975-5764
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Nigeria
  • [Chemical-registry-number] 0 / Anticonvulsants; 614OI1Z5WI / Valproic Acid
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25. Umeoka S, Koyama T, Miki Y, Akai M, Tsutsui K, Togashi K: Pictorial review of tuberous sclerosis in various organs. Radiographics; 2008 Nov-Dec;28(7):e32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis is a rare autosomal dominant neurocutaneous syndrome characterized by the presence of benign congenital tumors in multiple organs.
  • Because the classical triad of epilepsy, mental retardation, and adenoma sebaceum is uncommonly seen at clinical examination, radiologic examinations can play an important role in the diagnosis of tuberous sclerosis and in treatment.

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  • (PMID = 18772274.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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26. Yang HM, Cabral E, Dadras SS, Cassarino DS: Immunohistochemical expression of D2-40 in benign and malignant sebaceous tumors and comparison to basal and squamous cell carcinomas. Am J Dermatopathol; 2008 Dec;30(6):549-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of D2-40 in benign and malignant sebaceous tumors and comparison to basal and squamous cell carcinomas.
  • The diagnosis of sebaceous carcinoma presents an important challenge to both clinicians and pathologists, as many cases are initially misdiagnosed both clinically and histopathologically, potentially leading to adverse medical and legal outcomes.
  • The distinction of sebaceous carcinoma from benign sebaceous proliferations and other tumors is therefore of utmost importance, and immunohistochemistry may be useful in this differential.
  • We studied the expression of D2-40 (podoplanin) by immunohistochemistry to determine if it can aid in this differential diagnosis and to evaluate the possibility of lymphangiogenesis in sebaceous carcinoma.
  • A total of 36 cases of sebaceous lesions, including 16 sebaceous carcinomas, 7 sebaceous adenomas, 6 sebaceomas, and 7 cases of normal glands and sebaceous hyperplasia, and 17 cases of basal cell carcinoma and 10 cases of squamous cell carcinoma, were also examined.
  • We found no significant increase in tumor lymphangiogenesis by semiquantitative scoring of lymphovascular density per square millimeter of tumoral/peritumoral stroma in sebaceous carcinoma versus benign sebaceous proliferations.
  • However, D2-40 staining showed a different pattern in the benign tumors, which were positive only in the basaloid cells (most pronounced in sebaceoma), versus sebaceous carcinoma, which was either negative or focally positive in a haphazard pattern in most cases, although some cases of basaloid sebaceous carcinomas showed strong positivity.
  • Therefore, overall, D2-40 is, of limited diagnostic utility in sebaceous lesions but may be useful in distinguishing sebaceoma and basaloid sebaceous carcinoma from basal cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Antibodies, Monoclonal / metabolism. Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Glands / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / metabolism. Adenoma / pathology. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Proliferation. Diagnosis, Differential. Humans. Hyperplasia / diagnosis. Hyperplasia / metabolism. Hyperplasia / pathology

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  • (PMID = 19033927.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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27. Granata A, Basile A, Figuera M, Mignani R, Fiore CE: Spontaneous retroperitoneal hemorrhage due to massive rupture of renal angiomyolipoma treated with nephrectomy: an unusual onset of tuberous sclerosis complex. Clin Nephrol; 2009 Apr;71(4):441-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tuberous sclerosis complex (TSC) is a genetic and systemic disorder characterized by benign hamartomatous tumors that involve multiple organ systems.
  • The classical clinical triad of TSC consists of seizure, adenoma sebaceum (facial angiofibromata) and mental retardation.

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  • (PMID = 19356378.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Ghosh SK, Bandyopadhyay D, Chatterjee G, Ghosh A, Sarkar S, Sarkar S: Mucocutaneous changes in tuberous sclerosis complex: a clinical profile of 27 Indian patients. Indian J Dermatol; 2009 Jul;54(3):255-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease resulting in a wide array of clinical manifestations, primarily affecting the skin and central nervous system.
  • Adenoma sebaceum was the most common cutaneous feature (100%), followed by hypomelanotic macules (92.6%), connective tissue nevi (66.6%), and Koenen's tumors (33.3%).

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  • [Cites] J Urol. 2003 May;169(5):1635-42 [12686801.001]
  • [Cites] Dev Med Child Neurol. 2006 Jun;48(6):495-9 [16700943.001]
  • [Cites] J Child Neurol. 1998 Dec;13(12):624-8 [9881533.001]
  • [Cites] Indian J Dermatol Venereol Leprol. 2008 Jan-Feb;74(1):28-31 [18187819.001]
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  • [Cites] J Am Acad Dermatol. 2007 May;56(5):786-90 [17239986.001]
  • (PMID = 20161858.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2810693
  • [Keywords] NOTNLM ; Tuberous sclerosis / adenoma sebaceum / mucocutaneous / shagreen patch
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29. Haake DL, Minni JP, Nowak M, Abenoza P, Nousari CH: Reticulated acanthoma with sebaceous differentiation. Lack of association with Muir-Torre syndrome. Am J Dermatopathol; 2009 Jun;31(4):391-2
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  • [Title] Reticulated acanthoma with sebaceous differentiation. Lack of association with Muir-Torre syndrome.
  • We hereby report a case of a reticulated acanthoma with sebaceous differentiation (RASD), a rare and often mislabeled benign lesion that is characterized by epidermal acanthosis and clusters of sebocytes in a reticulated seborrheic keratosis-like pattern.
  • The presence of multiple sebaceous tumors, most notably cystic sebaceous adenomas and keratoacanthomas, has been associated with Muir-Torre syndrome (MTS).
  • [MeSH-major] Acanthoma / pathology. Muir-Torre Syndrome. Sebaceous Glands / pathology. Skin Neoplasms / pathology

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  • (PMID = 19461247.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Manonukul J, Kajornvuthidej S: Sebaceous neoplasms in Siriraj Hospital, Mahidol University: a 9-year-retrospective study. J Med Assoc Thai; 2010 Aug;93(8):978-91
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  • [Title] Sebaceous neoplasms in Siriraj Hospital, Mahidol University: a 9-year-retrospective study.
  • BACKGROUND: Sebaceous neoplasms are adnexal neoplasms that contain a varying number ofsebocytes, i.e. large cells with lipid-laden vacuolated cytoplasm, soap-bubble in appearance, and crenate nuclei.
  • Various sebaceous neoplasms with complex histopathologic features and varying degree ofsebaceous cells differentiation have been described in the literature.
  • OBJECTIVES: To study the prevalence of sebaceous neoplasms, i.e., nevus sebaceus, sebaceous hyperplasia, sebaceous adenoma, sebaceoma, sebaceous epithelioma, superficial epithelioma with sebaceous differentiation, and sebaceous carcinoma diagnosed in the Department of Pathology, Siriraj Hospital, Mahidol University during the 9-year-period between 1997 and 2005.
  • MATERIAL AND METHOD: A retrospective study of all sebaceous neoplasms including Nevus sebaceous, sebaceous hyperplasia, sebaceous adenoma, sebaceoma, sebaceous epithelioma, superficial epithelioma with sebaceous differentiation, sebaceous carcinoma, and all neoplasms containing the term "sebaceous" was performed.
  • Comparison between the previous diagnoses and the reviewed diagnoses was performed to assess the initial accuracy of all sebaceous neoplasms diagnosed.
  • Small-sized biopsies or biopsies that possess incomplete sebaceous differentiation, in which the sebocytes were few and subtle, sometimes are difFicult to diagnose.
  • RESULTS: Two hundred seven sebaceous neoplasms (2.34%) from the 8819 skin biopsies that were taken in the Department of Pathology, Siriraj Hospital during the 9-year-period, were included After exclusion of some authentically non-sebaceous neoplasms, 182 sebaceous neoplasms were found Nevus sebaceus (n=85, 46.7%) and sebaceous hyperplasia (n=64, 35.1%) were the two most common benign lesions.
  • The others were sebaceoma (n=3, 1.6%), sebaceous adenoma (n=2, 1.1%), sebaceous epithelioma (n=1, 0.5%), sebaceous carcinoma (n=26, 14.3%), and one unclassified sebaceous lesion that could not be considered a neoplasm.
  • Tumor degeneration was found in 14 nevus sebaceus in which 21 neoplasms existed, namely, trichilemmoma (wart)-like lesion (n=4), primitive follicular induction (n=7), syringocystadenoma papilliferum (n=3), trichoblastoma (n=3), and one of each of trichoepithelioma, sebaceous adenoma, tumor of follicular infundiculum, and mucoepidermoid carcinoma.
  • CONCLUSION: Twenty-six sebaceous carcinomas out of 182 sebaceous neoplasms, occurring mostly on the patients'eyelids, were found The most common sebaceous neoplasm was nevus sebaceus (n=85); the prophylactic excision of this lesion was recommended as tumor degeneration was frequent (14 out of 85 cases).
  • It was very helpful in the detection of sebocytes in basaloid cells in sebaceous neoplasms and among lymphoid cells within metastasized lymph nodes and a discriminant between sebaceous and nonsebaceous neoplasms.
  • [MeSH-major] Adenocarcinoma, Sebaceous / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 20718175.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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31. Gupta S, Bhowate R, Degwekar SS: Clinical and radiological findings related to tuberous sclerosis complex: a case report. J Contemp Dent Pract; 2008;9(4):85-91
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  • BACKGROUND: TSC is a rare neurocutaneous syndrome exhibiting multiple hamartomatous proliferations that may involve multiple organs such as the brain, kidney, heart, eyes, lungs and skin.
  • Associated findings were adenoma sebaceum (angiofibromas) on the face, a Shagreen patch on the lumbosacral region, ash leaf spots on the trunk, and subangual fibromas (Koenen's tumor) on the nails of fingers and toes.
  • The final diagnosis of TSC was made on the basis of the clinical findings of the skin, computerized tomography (CT) findings of the brain and kidney, ultrasonographic findings of kidney, and a histopathologic evaluation of the gingival growth which met the major and minor criteria required for a diagnosis of TSC.
  • [MeSH-minor] Adolescent. Angiofibroma / diagnosis. Cuspid / pathology. Diagnosis, Differential. Facial Neoplasms / diagnosis. Female. Fibroma / diagnosis. Humans. Hyperpigmentation / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis


32. Higgins HJ, Voutsalath M, Holland JM: Muir-torre syndrome: a case report. J Clin Aesthet Dermatol; 2009 Aug;2(8):30-2

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  • Muir-Torre syndrome is an autosomal dominant genodermatosis associated with sebaceous neoplasms and visceral malignancies.
  • Characteristic sebaceous neoplasms include sebaceous adenoma, sebaceous carcinoma, sebaceoma, and keratoacanthoma with sebaceous differentiation.
  • The clinical and histological features of a patient with Muir-Torre syndrome who had two sebaceous adenomas, multiple basal cell carcinomas, and frontal bossing in association with colon cancer are presented in this report.

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  • [Cites] Arch Dermatol. 1968 Nov;98(5):549-51 [5684233.001]
  • [Cites] Br J Surg. 1967 Mar;54(3):191-5 [6020987.001]
  • [Cites] J Am Acad Dermatol. 1995 Jul;33(1):90-104 [7601953.001]
  • [Cites] Dermatol Clin. 1995 Jan;13(1):79-89 [7712655.001]
  • [Cites] Cutis. 2005 Mar;75(3):149-55 [15839358.001]
  • [Cites] Lancet Oncol. 2005 Dec;6(12):980-7 [16321766.001]
  • [Cites] Am J Dermatopathol. 2006 Feb;28(1):56-9 [16456327.001]
  • [Cites] World J Surg Oncol. 2006;4:8 [16466577.001]
  • [Cites] Arch Dermatol. 2006 Aug;142(8):1039-42 [16924054.001]
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  • [Cites] Cutis. 2008 Oct;82(4):252-6 [19055168.001]
  • [Cites] Dermatol Ther. 2008 Nov-Dec;21(6):459-66 [19076624.001]
  • (PMID = 20729952.001).
  • [ISSN] 1941-2789
  • [Journal-full-title] The Journal of clinical and aesthetic dermatology
  • [ISO-abbreviation] J Clin Aesthet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2923964
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33. Weinstein A, Nouri K, Bassiri-Tehrani S, Flores F, Jimenez G: Muir-Torre syndrome: a case of this uncommon entity. Int J Dermatol; 2006 Mar;45(3):311-3
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  • She also had a history of colonic polyps and distal colonic villous adenoma.
  • On physical examination, in addition to scars from a radical mastectomy and midline abdominal laparotomy, four skin lesions were noted: two on the scalp, one on the tragus, and one on the mid-back.
  • The lesions on the scalp and mid-back revealed lobules of sebaceous cells in the dermis with a minority of surrounding basaloid cells, consistent with a diagnosis of sebaceous adenoma (Fig. 1).
  • Although the lesion on the frontal scalp also showed sebaceous differentiation, there were a greater number of basaloid cells, some with hyperchromatic nuclei and mitotic figures; this was consistent with a diagnosis of sebaceous epithelioma (Fig. 2).
  • No further treatment was required for these benign sebaceous tumors, but their presence defined our patient's condition as Muir-Torre syndrome.
  • Histologically, this lesion was also consistent with sebaceous epithelioma.
  • [MeSH-major] Breast Neoplasms / complications. Carcinoma, Basal Cell / complications. Colonic Neoplasms / complications. Skin Neoplasms / complications. Uterine Cervical Neoplasms / complications
  • [MeSH-minor] Adenoma / complications. Adenoma / genetics. Aged. Carcinoma / complications. Carcinoma / genetics. Female. Genetic Diseases, Inborn / genetics. Humans. Sebaceous Gland Neoplasms / complications. Sebaceous Gland Neoplasms / genetics. Syndrome


34. Manonukul J, Omeapinyan P, Vongjirad A: Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. Am J Dermatopathol; 2009 Oct;31(7):658-63
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  • [Title] Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case.
  • Nevus sebaceous of Jadassohn (SNJ) is a congenital, hamartoma of multiple skin structures and may classically evolve through several stages of maturation.
  • We report a case of a 66-year-old woman with a coexistence of trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum, syringocystadenoma papilliferum, and mucoepidermoid or adenosquamous carcinoma arising in 2 separate and persistent SNJ exhibiting on her face with subsequent parotid node metastasis.
  • We also reported the second instance of mucoepidermoid arising within the lesion of SNJ and also added sebaceous adenoma to the list of sebaceous tumors arising within this lesion.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology

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  • (PMID = 19652586.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Bertholom JL, Guyomard JL, Stock N, Dugast C, Martinel C, Chatel MA, Charlin JF: [Sebaceous tumors of the eyelids in a patient with Muir-Torre syndrome]. J Fr Ophtalmol; 2006 Jun;29(6):654-8
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  • [Title] [Sebaceous tumors of the eyelids in a patient with Muir-Torre syndrome].
  • It is characterized by cutaneous tumors (such as sebaceous adenomas, epitheliomas, or carcinoma, and/or keratoacanthomas) and internal malignancies.
  • Histological study of the exeresis biopsies of the eyelid lesions showed a sebaceous adenoma and an epidermoid carcinoma with sebaceous differentiation.
  • Eyelid sebaceous tumors require complete medical check-up in search of carcinoma.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Squamous Cell / pathology. Eyelid Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology

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  • (PMID = 16885896.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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36. Takeda H, Lyle S, Lazar AJ, Zouboulis CC, Smyth I, Watt FM: Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med; 2006 Apr;12(4):395-7
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  • [Title] Human sebaceous tumors harbor inactivating mutations in LEF1.
  • We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status.
  • Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors.
  • [MeSH-major] Amino Acid Substitution. Lymphoid Enhancer-Binding Factor 1 / genetics. Sebaceous Gland Neoplasms / genetics. Transcriptional Activation. beta Catenin / metabolism
  • [MeSH-minor] Adenoma / pathology. Alleles. Amino Acid Sequence. Base Sequence. Cell Line. Conserved Sequence. DNA / analysis. DNA / genetics. Gene Expression Regulation, Neoplastic. Genes, Reporter. Genetic Markers. Humans. Luciferases / analysis. Luciferases / metabolism. Molecular Sequence Data. Sequence Analysis, DNA. Sequence Homology, Amino Acid. Signal Transduction. Transcription, Genetic. Wnt Proteins / metabolism

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  • (PMID = 16565724.001).
  • [ISSN] 1078-8956
  • [Journal-full-title] Nature medicine
  • [ISO-abbreviation] Nat. Med.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR02179; United States / NIAMS NIH HHS / AR / P30AR042689
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers; 0 / Lymphoid Enhancer-Binding Factor 1; 0 / Wnt Proteins; 0 / beta Catenin; 9007-49-2 / DNA; EC 1.13.12.- / Luciferases
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37. Ginel PJ, Lucena R, Millán Y, González-Medina S, Guil S, García-Monterde J, de los Monteros AE, de las Mulas JM: Expression of oestrogen and progesterone receptors in canine sebaceous gland tumours. Vet Dermatol; 2010 Jun;21(3):297-302

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  • [Title] Expression of oestrogen and progesterone receptors in canine sebaceous gland tumours.
  • Sebaceous gland oestrogen alpha (ERalpha) and progesterone (PR) receptor expression was examined immunohistochemically in 26 and 32 dogs respectively with sebaceous gland hyperplasia/adenomas, epitheliomas and carcinomas, and in the glands of 10 healthy controls.
  • The mean percentage of ERalpha positive nuclei in control sebaceous glands was 21.31% compared with 11.5% in hyperplasia/adenoma-type lesions, although these values were not statistically different.
  • In sebaceous gland epitheliomas and carcinomas, positive basal cells represented 7.86% and 3.53% of neoplastic cells respectively and these mean percentages were significantly lower in epitheliomas (P < 0.024) and carcinomas (P < 0.015) than in controls.
  • The mean percentage of PR-positive nuclei in control sebaceous glands was 23.96%, similar to the 22.07% found in hyperplasia/adenoma-type lesions.
  • In sebaceous gland epitheliomas and carcinomas, positive cells were scarce and represented 13.5% and 4.06% of neoplastic cells respectively.
  • In the control group there was greater PR (P < 0.001) and ERalpha expression (P < 0.014) in sebaceous glands in female dogs.
  • The PR and ERalpha immunoreactivity in each category of neoplastic lesions could not be analysed because sample size was too small but when all the sebaceous gland tumours were grouped and analysed, no sex difference was found.
  • The results suggest that oestrogen and progesterone receptor expression is reduced in some canine sebaceous gland tumours.
  • [MeSH-major] Dog Diseases / metabolism. Estrogen Receptor alpha / biosynthesis. Receptors, Progesterone / biosynthesis. Sebaceous Gland Neoplasms / veterinary. Sebaceous Glands / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adenoma / veterinary. Animals. Carcinoma / metabolism. Carcinoma / pathology. Carcinoma / veterinary. Dogs. Female. Hyperplasia / metabolism. Hyperplasia / veterinary. Male. Sex Factors

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  • (PMID = 20030798.001).
  • [ISSN] 1365-3164
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Receptors, Progesterone
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38. Gerdes MJ, Yuspa SH: The contribution of epidermal stem cells to skin cancer. Stem Cell Rev; 2005;1(3):225-31
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  • [Title] The contribution of epidermal stem cells to skin cancer.
  • Tumors arising from the skin are of multiple phenotypes, with differing degrees of malignant potential.
  • In mouse models of skin carcinogenesis, tumors of squamous phenotype are the most common; however, human disease indicates that multiple phenotypes may arise from a common pool of stem cells that are then influenced by epigenetic factors.
  • The use of transgenic and knockout gene technologies with mice is unraveling some of the specific genes regulating fate determination in stem cells other than squamous lineage, including basal cell carcinoma and sebaceous adenomas.
  • [MeSH-major] Adenocarcinoma, Sebaceous / genetics. Carcinoma, Basal Cell / genetics. Epidermis. Epigenesis, Genetic. Neoplastic Stem Cells. Skin Neoplasms / genetics

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  • (PMID = 17142859.001).
  • [ISSN] 1550-8943
  • [Journal-full-title] Stem cell reviews
  • [ISO-abbreviation] Stem Cell Rev
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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39. Mercader P, García-Melgares ML, Roche E, Sánchez-Carazo JL, Alegre-de Miquel V: [Clinical follow-up and presence of visceral tumors in 12 patients with sebaceous gland tumors]. Actas Dermosifiliogr; 2008 Sep;99(7):532-9
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  • [Title] [Clinical follow-up and presence of visceral tumors in 12 patients with sebaceous gland tumors].
  • BACKGROUND: Sebaceous gland tumors are a rare type of neoplasm.
  • The aim of this study was to review the diagnosis and follow-up of a series of patients with sebaceous gland tumors to assess how many met the criteria for Muir-Torre syndrome.
  • PATIENTS AND METHODS: A search was performed of records from 1990 to 2005 in the database of the Department of Dermatology of the Consorcio Hospital General Universitario de Valencia in Valencia, Spain, to identify patients with sebaceous gland tumors.
  • RESULTS: We identified 20 patients diagnosed with sebaceous gland tumors, but after reviewing the biopsy material diagnosis was only confirmed in 12.
  • CONCLUSIONS: It is essential to rule out the presence of Muir-Torre syndrome in patients with sebaceous gland tumors.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / diagnosis. Adenocarcinoma, Sebaceous / epidemiology. Adenoma / diagnosis. Adenoma / epidemiology. Adult. Aged. Aged, 80 and over. Bowen's Disease / diagnosis. Carcinoma / diagnosis. Carcinoma / epidemiology. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / epidemiology. Carcinoma, Squamous Cell / diagnosis. Cell Differentiation. Diagnostic Errors. Endometrial Neoplasms / diagnosis. Endometrial Neoplasms / epidemiology. Endometrial Neoplasms / genetics. Female. Follow-Up Studies. Humans. Hyperplasia. Male. Microsatellite Instability. Middle Aged. Pedigree. Retrospective Studies. Spain / epidemiology. Young Adult

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  • (PMID = 18682166.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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40. Kazakov DV, Mukensnabl P, Michal M: Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. Am J Dermatopathol; 2006 Apr;28(2):142-6
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  • [Title] Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
  • The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues.
  • We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation.
  • The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia.
  • In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation.
  • [MeSH-major] Adenoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / pathology. Back. Cell Differentiation. Cell Lineage. Eosinophils / pathology. Epithelial Cells / pathology. Epithelium / pathology. Female. Fibroblasts / pathology. Follow-Up Studies. Hair Follicle / pathology. Head and Neck Neoplasms / pathology. Humans. Middle Aged. Scalp / pathology. Sebaceous Glands / pathology

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  • (PMID = 16625077.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Guillén-Ponce C, Castillejo A, Barberá VM, Pascual-Ramírez JC, Andrada E, Castillejo MI, Guarinós C, Molina-Garrido MJ, Carrato A, Soto JL: Biallelic MYH germline mutations as cause of Muir-Torre syndrome. Fam Cancer; 2010 Jun;9(2):151-4
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  • Muir-Torre syndrome is a rare, inherited disease predisposing of gastrointestinal and cutaneous tumours, such as keratoacanthomas and sebaceous gland adenomas.
  • This report describes a man who has multiple adenomatous colon polyps, a gastric cancer, multiple colorectal cancers and sebaceous adenomas caused by biallelic MYH germline mutations.

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  • (PMID = 19998059.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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42. Tsalis K, Blouhos K, Vasiliadis K, Tsachalis T, Angelopoulos S, Betsis D: Sebaceous gland tumors and internal malignancy in the context of Muir-Torre syndrome. A case report and review of the literature. World J Surg Oncol; 2006;4:8

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  • [Title] Sebaceous gland tumors and internal malignancy in the context of Muir-Torre syndrome. A case report and review of the literature.
  • BACKGROUND: The Muir-Torre syndrome is a rare autosomal dominant condition and is currently considered a subtype of the more common hereditary nonpolyposis colorectal cancer syndrome, in which multiple primary malignancies occur together with sebaceous gland tumors.
  • CASE PRESENTATION: We describe a case of a 62-year-old woman with three primary colorectal tumors, genital tumor, and sebaceous adenomas and present her family history of three generations.
  • CONCLUSION: Recognition of the syndrome in patients with sebaceous gland tumors should facilitate early detection of subsequent malignancies if the patient is entered into appropriate screening programs.

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  • [Cites] Am J Dermatopathol. 2004 Jun;26(3):217-21 [15166510.001]
  • [Cites] Arch Dermatol. 1968 Nov;98(5):549-51 [5684233.001]
  • [Cites] J Am Acad Dermatol. 1999 Nov;41(5 Pt 1):681-6 [10534628.001]
  • [Cites] Dermatology. 2000;200(4):331-3 [10894967.001]
  • [Cites] Am J Surg Pathol. 2002 Mar;26(3):338-43 [11859205.001]
  • [Cites] J Cutan Pathol. 2003 Mar;30(3):178-84 [12641777.001]
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  • [Cites] Am J Gastroenterol. 1998 Sep;93(9):1572-4 [9732950.001]
  • [Cites] Dermatol Clin. 1995 Jan;13(1):79-89 [7712655.001]
  • [Cites] J Am Acad Dermatol. 1995 Jul;33(1):90-104 [7601953.001]
  • [Cites] Br J Surg. 1967 Mar;54(3):191-5 [6020987.001]
  • [Cites] J Am Acad Dermatol. 2004 Mar;50(3):476-8 [14988697.001]
  • [Cites] Cancer. 2005 Mar 1;103(5):1018-25 [15662714.001]
  • [Cites] Cutis. 2005 Mar;75(3):149-55 [15839358.001]
  • (PMID = 16466577.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1386670
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43. Klieb HB, Perez-Ordoñez B: Oncocytic lipoadenoma of the parotid gland with sebaceous differentiation. Study of its keratin profile. Virchows Arch; 2006 Dec;449(6):722-5
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  • [Title] Oncocytic lipoadenoma of the parotid gland with sebaceous differentiation. Study of its keratin profile.
  • Oncocytic lipoadenomas of salivary gland are extremely rare tumors with only two previously reported cases.
  • In this paper, we describe an additional example of oncocytic lipoadenoma showing sebaceous differentiation, a hitherto unreported occurrence.
  • Terminally differentiated sebaceous cells were positive for EMA and keratin 14 only.
  • The keratin profile and p63 expression of this oncocytic lipoadenoma suggest the presence of a dual cell population somewhat similar to the dual cell population described in some ultrastructural studies of pure salivary gland oncocytomas and may represent partial basal-cell differentiation.
  • [MeSH-major] Adenoma / pathology. Keratins / analysis. Lipoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17091251.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins
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44. Nolan L, Eccles D, Cross E, Crawford G, Beck N, Bateman A, Ottensmeier C: First case report of Muir-Torre syndrome associated with non-small cell lung cancer. Fam Cancer; 2009;8(4):359-62
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  • The eponymous Muir-Torre syndrome (MTS) is a clinical variant of hereditary non polyposis colorectal cancer, and is defined as an autosomal dominant condition with simultaneous sebaceous neoplasms of the skin and visceral malignant disease resulting from germline mutations in the DNA mismatch repair (MMR) genes.
  • Other clearly associated tumours include endometrial adenocarcinomas, urothelial transitional cell carcinomas, upper gastrointestinal adenocarcinomas, sebaceous adenomas and ovarian (often mucinous) carcinomas.

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  • (PMID = 19449129.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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45. Marazza G, Masouyé I, Taylor S, Prins C, Gaudin T, Saurat JH, French LE: An illustrative case of Muir-Torre syndrome: contribution of immunohistochemical analysis in identifying indicator sebaceous lesions. Arch Dermatol; 2006 Aug;142(8):1039-42
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  • [Title] An illustrative case of Muir-Torre syndrome: contribution of immunohistochemical analysis in identifying indicator sebaceous lesions.
  • BACKGROUND: Muir-Torre syndrome (MTS) is an autosomal dominant genodermatosis characterized by the association of at least 1 cutaneous sebaceous tumor and 1 internal malignancy, often arising in the gastrointestinal tract.
  • OBSERVATIONS: We report the case of a 54-year-old man with a 2-year history of skin-colored papules clinically reminiscent of large sebaceous hyperplasias on the nose and back, but histologically diagnosed as sebaceous adenomas and epitheliomas.
  • [MeSH-major] Adenocarcinoma, Sebaceous / diagnosis. Colorectal Neoplasms, Hereditary Nonpolyposis. Sebaceous Gland Neoplasms / diagnosis

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  • (PMID = 16924054.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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46. Orta L, Klimstra DS, Qin J, Mecca P, Tang LH, Busam KJ, Shia J: Towards identification of hereditary DNA mismatch repair deficiency: sebaceous neoplasm warrants routine immunohistochemical screening regardless of patient's age or other clinical characteristics. Am J Surg Pathol; 2009 Jun;33(6):934-44
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  • [Title] Towards identification of hereditary DNA mismatch repair deficiency: sebaceous neoplasm warrants routine immunohistochemical screening regardless of patient's age or other clinical characteristics.
  • Although the significance of immunohistochemical detection of DNA mismatch repair proteins and/or microsatellite instability testing in identifying patients at risk for germline deficiency in DNA mismatch repair genes is well established in colorectal carcinomas, the proper use of such techniques in sebaceous neoplasms, another tumor type that has been implicated in patients with hereditary DNA mismatch repair deficiency, has not been clearly defined.
  • In this study, we stratified a series of 27 patients with 1 or more sebaceous neoplasms based on the pattern of immunohistochemical expression of MLH1, MSH2, MSH6, and PMS2, and comparatively analyzed their clinical and pathologic characteristics, including tumor-infiltrating lymphocytes and peritumoral lymphocytic response as determined by immunohistochemical staining for CD3.
  • The study tissue samples included 30 sebaceous carcinomas, 14 sebaceous adenomas, and 7 sebaceous hyperplasias, along with 8 concurrent nonsebaceous lesions from 6 patients.
  • Overall, 12 of the 27 (44%) patients showed abnormal IHC staining with mismatch repair proteins in their sebaceous tumors, the most commonly seen abnormality being concurrent loss of MSH2 and MSH6 (8/12, 67%).
  • Sebaceous adenomas and carcinomas occurring in the same patients showed an identical staining pattern, as did hereditary nonpolyposis colorectal cancer-related nonsebaceous tumors in the same patients.
  • Furthermore, sebaceous tumors with abnormal expression had significantly higher CD3-positive tumor-infiltrating lymphocytes and peritumoral lymphocytic response.
  • On such a premise, given that sebaceous neoplasms are only infrequently encountered, and that immunohistochemistry is easily available and reasonably reliable, we recommend that, when there exists a desire to identify hereditary DNA mismatch repair deficiency, routine immunohistochemical detection of DNA mismatch repair proteins be performed in all sebaceous neoplasms regardless of patient's age or other clinical characteristics.
  • [MeSH-major] Adenocarcinoma, Sebaceous / genetics. Adenocarcinoma, Sebaceous / metabolism. DNA Mismatch Repair / genetics

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  • (PMID = 19342947.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3
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47. Shalin SC, Lyle S, Calonje E, Lazar AJ: Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications. Histopathology; 2010 Jan;56(1):133-47
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  • [Title] Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications.
  • Sebaceous neoplasia comprises a spectrum ranging from benign to malignant.
  • Our increased understanding of the significance and pathogenesis of these tumours has led to improved risk stratification, screening recommendations, and treatment of patients with an initial presentation of a sebaceous tumour.
  • This review focuses on the diagnostic and histological features of sebaceous lesions, the MTS, and recent insights into the molecular pathogenesis of sebaceous tumours.

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  • (PMID = 20055911.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA118916-04; United States / NCI NIH HHS / CA / R01 CA118916; United States / NCI NIH HHS / CA / 1R01CA118916; United States / NCI NIH HHS / CA / R01 CA118916-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 108
  • [Other-IDs] NLM/ NIHMS158792; NLM/ PMC2805836
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48. Lester LU, Rapini RP: Dermatologic manifestations of colonic disorders. Curr Opin Gastroenterol; 2009 Jan;25(1):66-73
MedlinePlus Health Information. consumer health - Skin Conditions.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE OF REVIEW: The skin is often a mirror for matters of internal diseases including disorders of the gastrointestinal tract.
  • RECENT FINDINGS: Muir-Torre syndrome involves cutaneous sebaceous adenomas and internal malignancy; screening of cutaneous lesions for microsatellite instability, and absence of mismatch repair genes provides an opportunity for diagnosis of the syndrome.
  • Degos' disease is a vasoocclusive disorder involving the cutaneous and gastrointestinal systems; this disease affects all ages with significant mortality, yet a benign variant only affecting the skin is described.
  • Metastatic Crohn's disease is the development of noncaseating granulomas at skin sites not contiguous with the gastrointestinal tract; cutaneous lesions may precede the onset of colonic disease or appear in the absence of active bowel disease, and extensive surgical debridement of perineal lesions is often necessary.
  • [MeSH-major] Colonic Diseases. Skin Diseases
  • [MeSH-minor] Colon / pathology. Diagnosis, Differential. Global Health. Humans. Mass Screening. Morbidity. Skin / pathology

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  • (PMID = 19119511.001).
  • [ISSN] 1531-7056
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 49
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49. Grzybowski A, Jabłońska S: Muir-Torre syndrome-is it really a new syndrome? Am J Dermatopathol; 2009 Dec;31(8):799-802
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This syndrome is defined as the coexistence of sebaceous adenomas, sebaceus carcinomas, keratoacanthomas, and pedunculated tumors, some with lobulated structure.
  • The cutaneous involvement (sebaceous gland tumor) is associated with at least a single internal malignancy; mostly colonorectal or genitourinary malignancies.
  • The lobulated structures developed from the sebaceous glands, which were larger than normal, and surrounded by abundant fibrous tissue.

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  • (PMID = 19955878.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Portraits
  • [Publication-country] United States
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50. Jones B, Oh C, Mangold E, Egan CA: Muir-Torre syndrome: Diagnostic and screening guidelines. Australas J Dermatol; 2006 Nov;47(4):266-9
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  • A 65-year-old man presented with a history of multiple skin coloured papules on his face that were asymptomatic.
  • Diagnostic biopsies showed the lesions to be sebaceous adenomas and epitheliomas and the diagnosis of Muir-Torre syndrome was made.
  • The sebaceous tumour tissue showed microsatellite instability and immunohistochemical staining indicated diminished expression in the DNA mismatch-repair protein complex MSH2/MSH6.
  • [MeSH-major] Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Genetic Predisposition to Disease. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Gland Neoplasms / genetics

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  • (PMID = 17034469.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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51. Abbas O, Mahalingam M: Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. J Cutan Pathol; 2009 Jun;36(6):613-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm.
  • Sebaceous gland neoplasms such as adenoma, epithelioma, and carcinoma are uncommon cutaneous tumors.
  • MTS is a rare autosomal dominant genodermatosis characterized by the occurrence of sebaceous gland neoplasms and/or keratoacanthomas associated with visceral malignancies that include gastrointestinal and genitourinary cancers.
  • Given that some sebaceous neoplasms represent cutaneous markers of MTS, what should we as dermatopathologists be advocating?
  • Should we be looking for absence/loss of MMRs in all sebaceous neoplasms?
  • This review attempts to address all of these issues with a view to streamlining the work-up of a patient presenting for the first time with a sebaceous neoplasm and no prior personal or family history of internal malignancies.
  • [MeSH-major] Algorithms. Biomarkers, Tumor / genetics. Muir-Torre Syndrome / diagnosis. Sebaceous Gland Neoplasms / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19515040.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 36
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52. Thamboo TP, Tan LH, Tan SY: Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. J Cutan Pathol; 2006 Jan;33(1):27-32
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  • [Title] Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors.
  • Little is known about the expression of Bcl-x in cutaneous adnexal structures and benign cutaneous adnexal tumors.
  • METHODS: Tissues from 31 cases of benign cutaneous adnexal tumors (five trichofolliculomas, five trichoepitheliomas, two sebaceous adenomas, five apocrine hidradenomas, five eccrine poromas, five eccrine spiradenomas, and four syringomas) were immunostained for Bcl-x.
  • Sebaceous gland cells showed strong staining.
  • Apocrine gland cells showed weak to moderate staining.
  • No staining was seen in eccrine gland cells.
  • In sebaceous adenomas, the sebaceous cells showed strong staining while the basaloid cells were negative.
  • This pattern is recapitulated in the corresponding benign cutaneous adnexal tumors.
  • Bcl-x may be useful in identifying cells with sebaceous differentiation in poorly differentiated adnexal tumors.
  • [MeSH-major] Neoplasms, Adnexal and Skin Appendage / metabolism. Skin / metabolism. Skin Neoplasms / metabolism. bcl-X Protein / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Epidermis / metabolism. Epidermis / pathology. Humans. Immunoenzyme Techniques. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Sweat Glands / metabolism. Sweat Glands / pathology

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  • (PMID = 16441408.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / bcl-X Protein
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53. Kacerovská D, Kazakov DV, Cerná K, Hadravský L, Michal M Jr, Dostál J, Skálová A Jr, Michal M: [Muir-Torre syndrome--a phenotypic variant of Lynch syndrome]. Cesk Patol; 2010 Oct;46(4):86-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MTS combines at least one cutaneous neoplasm with sebaceous differentiation (e.g. sebaceoma, sebaceous adenoma, and sebaceous carcinoma), and at least one visceral malignancy.
  • [MeSH-minor] DNA Mismatch Repair / genetics. Genotype. Germ-Line Mutation. Humans. Microsatellite Instability. Phenotype. Skin Neoplasms / diagnosis. Skin Neoplasms / genetics. Skin Neoplasms / pathology

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  • (PMID = 21313735.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
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54. Shinozaki A, Nagao T, Endo H, Kato N, Hirokawa M, Mizobuchi K, Komatsu M, Igarashi T, Yokoyama M, Masuda S, Sano K, Izumi M, Fukayama M, Mukai K: Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant. Am J Surg Pathol; 2008 Jun;32(6):913-23
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  • [Title] Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant.
  • A recent report demonstrates sebaceous differentiation in this tumor even though its significance has never been documented as a precise histologic variant.
  • Six cases of EMC exhibiting sebaceous differentiation (sebaceous EMC) of the parotid gland were analyzed for their clinicopathologic features and immunohistochemical characteristics.
  • In addition, primary salivary sebaceous carcinomas were also examined for comparison.
  • In our series, the incidence of sebaceous EMC was 0.2% among 3012 cases of parotid gland tumors and 14.3% of all EMC cases.
  • Neither cervical lymph node nor distant organ metastases were found in any cases of sebaceous EMC and no patients died of disease, though local recurrences developed in 1 patient.
  • Conversely, cervical lymph node metastasis was detected in 2 of 3 patients with sebaceous carcinoma, 1 of whom died of disease at 12 months.
  • Histologically, all 6 tumors had an area of sebaceous differentiation admixed with features of bilayered ductal structures typical of EMC.
  • A component of sebaceous differentiation was distributed diffusely in 4 tumors and focally in 2.
  • Cytologic atypia of sebaceous EMCs was lesser than that of sebaceous carcinomas.
  • Immunohistochemically, putative myoepithelial markers such as alpha-smooth muscle actin, calponin, p63, cytokeratin 14, S-100 protein, and vimentin were highly expressed in sebaceous EMC.
  • However, the expression of the latter 4 markers was also observed in primary sebaceous carcinomas, whereas these tumors were all negative for alpha-smooth muscle actin and calponin.
  • Positive immunoreactivity for epithelial membrane antigen, adipophilin, and perilipin confirmed sebaceous differentiation in EMC.
  • These results indicate that sebaceous EMC is a low-grade malignancy, similar to conventional EMC.
  • Our data also suggest that immunohistochemical examination of specific myoepithelial markers is helpful in distinguishing sebaceous EMC from sebaceous carcinoma, which may occasionally be associated with an aggressive clinical course.
  • [MeSH-major] Adenoma / diagnosis. Myoepithelioma / diagnosis. Neoplasms, Glandular and Epithelial / diagnosis. Parotid Neoplasms / diagnosis


55. Hare HH, Mahendraker N, Sarwate S, Tangella K: Muir-Torre syndrome: a rare but important disorder. Cutis; 2008 Oct;82(4):252-6
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  • Muir-Torre syndrome (MTS) is a rare disorder characterized by the presence of at least one sebaceous gland neoplasm and at least one visceral malignancy.
  • Sebaceous adenomas, sebaceous carcinomas, and sebaceomas (sebaceous epitheliomas) are all characteristic glandular tumors of MTS.
  • We report 2 patients with MTS who developed colon adenocarcinomas in conjunction with sebaceous carcinomas.
  • We conclude that the diagnosis of rare sebaceous lesions associated with MTS may represent a marker of visceral disease and warrants further investigation for internal malignancies in the individual and at-risk family members.

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  • (PMID = 19055168.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Straub BK, Herpel E, Singer S, Zimbelmann R, Breuhahn K, Macher-Goeppinger S, Warth A, Lehmann-Koch J, Longerich T, Heid H, Schirmacher P: Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis. Mod Pathol; 2010 Mar;23(3):480-92
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  • Although adipophilin and TIP47 stained almost ubiquitously the rim of lipid droplets in various tumor types, especially those with clear cell phenotype, perilipin was restricted to lipid droplets of hepatocellular adenoma and carcinoma, sebaceous adenoma and carcinoma, and lipomatous tumors.

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  • (PMID = 20081801.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / PLIN3 protein, human; 0 / Phosphoproteins; 0 / Pregnancy Proteins; 0 / Vesicular Transport Proteins; 0 / perilipin 1; 0 / perilipin 2
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57. Singh RS, Grayson W, Redston M, Diwan AH, Warneke CL, McKee PH, Lev D, Lyle S, Calonje E, Lazar AJ: Site and tumor type predicts DNA mismatch repair status in cutaneous sebaceous neoplasia. Am J Surg Pathol; 2008 Jun;32(6):936-42
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  • [Title] Site and tumor type predicts DNA mismatch repair status in cutaneous sebaceous neoplasia.
  • Cutaneous sebaceous neoplasia is known to exhibit a high degree of DNA mismatch repair (MMR) deficiency leading to microsatellite instability and these tumors can be markers of the Muir-Torre syndrome and internal malignancy.
  • There are few comprehensive studies of unselected cutaneous sebaceous neoplasms.
  • To address this gap in knowledge, we examined 94 sebaceous neoplasms from 92 patients and 17 sebaceous hyperplasia controls using immunohistochemistry for MLH1, MSH2, and MSH6.
  • Our results indicate that MMR deficiency is significantly associated with anatomic location (more frequently in the trunk and extremities as compared with head and neck), tumor type (more often in adenoma compared with carcinoma within the head and neck region), and architecture (keratoacanthomalike).
  • Cutaneous sebaceous neoplasia has tendencies toward certain tumor types and anatomic distribution based on MMR status analogous to that seen in colonic carcinomas and other tumors.
  • [MeSH-major] Adenoma / genetics. Carcinoma / genetics. Head and Neck Neoplasms / genetics. Sebaceous Gland Neoplasms / genetics


58. Levi Z, Hazazi R, Kedar-Barnes I, Hodak E, Gal E, Mor E, Niv Y, Winkler J: Switching from tacrolimus to sirolimus halts the appearance of new sebaceous neoplasms in Muir-Torre syndrome. Am J Transplant; 2007 Feb;7(2):476-9
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  • [Title] Switching from tacrolimus to sirolimus halts the appearance of new sebaceous neoplasms in Muir-Torre syndrome.
  • We describe a kidney transplant recipient with unrecognized Muir-Torre syndrome in whom the administration of a tacrolimus-based regimen led to the eruption of multiple sebaceous tumors.
  • [MeSH-major] Adenoma / prevention & control. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Immunosuppressive Agents / therapeutic use. Sebaceous Gland Neoplasms / prevention & control. Sirolimus / therapeutic use. Tacrolimus / adverse effects

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  • (PMID = 17229076.001).
  • [ISSN] 1600-6135
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein; W36ZG6FT64 / Sirolimus; WM0HAQ4WNM / Tacrolimus
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59. Lachiewicz AM, Wilkinson TM, Groben P, Ollila DW, Thomas NE: Muir-Torre syndrome. Am J Clin Dermatol; 2007;8(5):315-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this case report of Muir-Torre syndrome (MTS), we describe a 47-year-old man with a personal and family history of colon cancer and a personal history of keratoacanthoma who presented with a sebaceous carcinoma and, subsequently, had a cystic sebaceous tumor.
  • MTS is a rare genodermatosis defined clinically by the occurrence of a sebaceous neoplasm and an internal malignancy in the absence of other predisposing factors.
  • Most patients present with sebaceous adenomas, but cystic sebaceous neoplasms have been reported as specific markers of MTS.
  • Physicians should consider MTS in patients presenting with a sebaceous neoplasm, and immunohistochemical examination of tumors for MSH2 and MLH1 protein can be used as a screening test to identify patients with MTS.
  • While the sebaceous and internal neoplasms of MTS are thought to follow a more indolent course than sporadic malignancies, patients with this disorder should be treated with standard therapies and carefully followed.
  • Additionally, most experts believe that an annual history and physical examination, including a complete skin examination and urinalysis, as well as periodic endometrial sampling and/or transvaginal ultrasound for women, are worthwhile screening tests for these high-risk patients.
  • [MeSH-major] Adenocarcinoma. Adenocarcinoma, Sebaceous / diagnosis. Colorectal Neoplasms. Sebaceous Gland Neoplasms / diagnosis

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  • (PMID = 17902735.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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60. Archer-Dubon C, Alvarez-Zavala B, Reyes E, Orozco-Topete R: Immunohistochemistry screening of sebaceous lesions for Muir-Torre syndrome in a 26-year period in a Mexican population. Dermatol Online J; 2008;14(12):1
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  • [Title] Immunohistochemistry screening of sebaceous lesions for Muir-Torre syndrome in a 26-year period in a Mexican population.
  • Muir-Torre syndrome (MTS) is an autosomal dominant genodermatosis defined as the association of rare sebaceous gland skin tumors, keratoacanthomas, and a personal or familial history of malignant visceral tumors.
  • We reviewed our series of sebaceous neoplasms and performed immunohistochemistry (IHC) in order to screen for new MTS cases.
  • Sebaceous neoplasms and visceral tumors from the same patient diagnosed between 1980-2006 were included.
  • Immunohistochemistry to determine the presence or absence of MMR gene products in skin and visceral tumors was performed with mouse monoclonal antibodies anti-MSH2, anti-MSH6 and anti-MLH1.
  • Six sebaceous neoplasms were identified in six females.
  • Immunohistochemistry is a useful and accessible technique for the characterization of MMR gene expression in patients with sebaceous neoplasms.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma / diagnosis. Immunohistochemistry. Muir-Torre Syndrome / diagnosis. Sebaceous Gland Neoplasms / diagnosis. Sebaceous Glands / metabolism

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  • (PMID = 19265614.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antibodies, Monoclonal; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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61. Fulciniti F, Losito NS, Ionna F, Longo F, Aversa C, Botti G, Foschini MP: Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation. Diagn Cytopathol; 2010 May;38(5):368-73

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation.
  • In line with numerous other pathological analogies between breast and salivary gland lesions, SPA shares with fibrocystic disease of the breast many histopathological features, i.e., fibrosis, oncocytic (apocrine) changes, hyperplasia of ductal and acinar epithelium, cystic dilation of ducts, and, often, atypical epithelial changes.
  • Most of the described cases have followed a benign clinical course, despite the frequent possibility of atypical hyperplasia in more than 50% of the cases and of the more than occasional in situ malignant transformation.
  • In this article, we introduce a new case occurring in the parotid gland of a 57-year-old male showing atypical epithelial hyperplasia and low-grade in situ mucoepidermoid carcinoma.
  • The spectrum of pathological lesions entering differential diagnosis comprised sebaceous adenoma, Warthin's tumors with presence of sebaceous remnants, and low-grade mucoepidermoid carcinoma.
  • The cytological diagnosis of SPA should be entertained whenever a polymorphous picture is found on FNC samples comprising oncocytic/apocrine changes, sebaceous cells, cystic background, and epithelial hyperplasia with low-grade cytological atypias.
  • [MeSH-major] Carcinoma in Situ / diagnosis. Carcinoma in Situ / pathology. Cell Transformation, Neoplastic / pathology. Cysts / pathology. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • (PMID = 19937766.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Kazakov DV, Soukup R, Mukensnabl P, Boudova L, Michal M: Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation. Am J Dermatopathol; 2005 Feb;27(1):27-33
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  • [Title] Brooke-Spiegler syndrome: report of a case with combined lesions containing cylindromatous, spiradenomatous, trichoblastomatous, and sebaceous differentiation.
  • The histopathological survey revealed a plethora of benign adnexal neoplasms showing apocrine, follicular, and sebaceous differentiation occurring independently and conjointly.
  • Some spiradenocylindromas demonstrated prominent sebaceous or trichoblastomatous differentiation or both.
  • We suggest the terms "sebaceous spiradenocylindroma" and "trichospiradenocylindroma" for these lesions.
  • The occurrence of sebaceous and trichoblastic differentiation in spiradenocylindromas is a further proof that spiradenoma and cylindroma are not eccrine tumors but neoplasms of the folliculosebaceousapocrine unit.
  • [MeSH-major] Carcinoma, Skin Appendage / pathology. Neoplasms, Multiple Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adenoma, Sweat Gland / pathology. Adenoma, Sweat Gland / surgery. Aged. Biomarkers, Tumor / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Adenoid Cystic / surgery. Hair Diseases / metabolism. Hair Diseases / pathology. Hair Diseases / surgery. Hair Follicle / metabolism. Hair Follicle / pathology. Humans. Immunoenzyme Techniques. Male. Sebaceous Glands / metabolism. Sebaceous Glands / pathology. Syndrome

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  • (PMID = 15677973.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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63. Vazmitel M, Michal M, Mukensnabl P, Kazakov DV: Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case. Am J Dermatopathol; 2008 Feb;30(1):51-3
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  • [Title] Syringocystadenoma papilliferum with sebaceous differentiation in an intradermal tubular apocrine component. Report of a case.
  • Syringocystadenoma papilliferum is a benign tumor most commonly located on the scalp or face, and it often arises within a nevus sebaceus of Jadassohn.
  • We describe a 61-year-old man with syringocystadenoma papilliferum developing within a nevus sebaceus with sebaceous differentiation in an intradermal tubular apocrine component of the syringocystadenoma papilliferum.
  • Although some adnexal neoplasms that develop in association with a nevus sebaceus may exhibit conjoint sebaceous, follicular, or apocrine differentiation, reflecting close embryological relations of the folliculosebaceous-apocrine unit, the feature we report on has not previously been described to the best of our knowledge.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18212545.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Minami S, Sadanobu N, Ito T, Natsuaki M, Yamanishi K: Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases. J Dermatol; 2006 Apr;33(4):256-9

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  • [Title] Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases.
  • Hidradenoma papilliferum is a benign tumor that usually occurs in the female anogenital region.
  • The lesion contained sebaceous differentiation, which has not been previously documented in the histopathology of hidradenoma papilliferum.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Facial Neoplasms / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 16674789.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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65. Kazakov DV, Kutzner H, Spagnolo DV, Kempf W, Zelger B, Mukensnabl P, Michal M: Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma). Am J Dermatopathol; 2008 Feb;30(1):21-6
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  • [Title] Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma).
  • We describe 11 poroid neoplasms with sebaceous differentiation, including a metaplastic (sarcomatoid) carcinoma arising in association with an apocrine poroma.
  • In all cases, sebaceous differentiation was identified as clustered or solitary, mature sebocytes occurring mainly at the periphery of intradermal cellular aggregations, accompanied by sebaceous ducts.
  • One poroma, in addition to sebaceous differentiation, showed decapitation secretion in some ductular structures.
  • Our study supports previous findings that sebaceous differentiation can be identified not only in classical poroma but also in the related lesions known as dermal duct tumor and poroid hidradenoma.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Neoplasms, Multiple Primary / pathology. Sarcoma / pathology. Sebaceous Glands / pathology. Skin Neoplasms / pathology

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  • (PMID = 18212539.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. El Demellawy D, Escott N, Salama S, Alowami S: Sebaceoma of the external ear canal: an unusual location. Case report and review of the literature. J Cutan Pathol; 2008 Oct;35(10):963-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous neoplasms of the external ear canal are extremely rare.
  • Only two cases of sebaceous neoplasms have been reported in the English literature, a sebaceous carcinoma and a sebaceous adenoma.
  • We highlight the differential diagnosis, particularly sebaceous carcinoma and basal cell carcinoma with sebaceous differentiation.
  • [MeSH-major] Ear Canal / pathology. Sebaceous Gland Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Aged. Carcinoma, Basal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18564279.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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67. Samaila MO: Adnexal skin tumors in Zaria, Nigeria. Ann Afr Med; 2008 Mar;7(1):6-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adnexal skin tumors in Zaria, Nigeria.
  • BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line.
  • METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006.
  • Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas.
  • Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma.
  • Forty-six lesions (88.5%) were benign and six (11.5%) malignant.
  • CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors.
  • The commonest variants are those of eccrine sweat gland origin.
  • [MeSH-major] Carcinoma, Skin Appendage / classification. Neoplasms, Adnexal and Skin Appendage / classification
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / pathology. Adenoma, Sweat Gland / epidemiology. Adenoma, Sweat Gland / pathology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Hair Follicle / pathology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / pathology. Humans. Infant, Newborn. Male. Middle Aged. Nigeria / epidemiology. Retrospective Studies. Sebaceous Gland Neoplasms / epidemiology. Sebaceous Gland Neoplasms / pathology. Sweat Gland Neoplasms / epidemiology. Sweat Gland Neoplasms / pathology

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  • (PMID = 18702242.001).
  • [ISSN] 1596-3519
  • [Journal-full-title] Annals of African medicine
  • [ISO-abbreviation] Ann Afr Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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68. Ilie M, Hofman V, Pedeutour F, Attias R, Santini J, Hofman P: Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis. Pathol Res Pract; 2010 Jan 15;206(1):66-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic lipoadenoma of the parotid gland: Immunohistochemical and cytogenetic analysis.
  • Salivary gland oncocytic lipoadenoma is an exceptional benign tumor composed of mature adipose tissue associated with a mixture of oncocytes.
  • We report a case of oncocytic lipoadenoma showing sebaceous differentiation, and provide a cytogenetic analysis, which has not yet been described.
  • A 64-year-old male developed a left parotid gland, well-encapsulated tumor measuring 3.5 x 3 cm(2), showing mature fat cells associated with oncocytic changes of epithelial components.
  • Such alterations in HMGA2 have been described in both lipomas and pleomorphic adenomas of the salivary glands.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19346081.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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69. Pedemonte JG, Degiovanni D, Pusterla D, Reibel C, Di Nucci J, Boccio C, Degiovanni R, Dotta A: [Angiomyolipoma and Lenk syndrome: case report]. Actas Urol Esp; 2008 Sep;32(8):850-4
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  • Angiomyolipoma (AML) is a benign clonal neoplasm that consists of varying amounts of mature adipose tissue, smooth muscle, and thick-walled vessels.
  • Approximately 20% of AMLs are found in patients with tuberous sclerosis syndrome (TS), an autosomal-dominant disorder characterized by mental retardation, epilepsy, and adenoma sebaceous, a distinctive skin lesion.

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  • (PMID = 19013986.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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70. Siddiqui NH, Wu SJ: Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report. Diagn Cytopathol; 2005 Apr;32(4):229-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration biopsy of cystic pleomorphic adenoma with adnexa-like differentiation mimicking mucoepidermoid carcinoma: a case report.
  • Although pleomorphic adenomas (PAs) usually can be diagnosed very accurately with fine-needle aspiration biopsy (FNAB), even this common salivary gland neoplasm can be diagnostically challenging and cause pitfalls in cytodiagnosis.
  • In particular, the presence of either cystic changes or squamous, mucinous, or sebaceous metaplasia can lead to a false positive diagnosis of mucoepidermoid carcinoma (MEC).
  • The FNAB cytology revealed cohesive clusters of squamous epithelial cells, sebaceous cells, oncocytes, macrophages, and rare myoepithelial cells.
  • The subsequent parotidectomy specimen revealed an encapsulated cystic PA with mixed appendageal differentiation including areas of squamous, mucinous, sebaceous, and oncocytic metaplasia.
  • Presence of squamous, mucinous, and/or sebaceous metaplasia, especially in the absence of chondromyxoid stroma, presents the potential for misinterpretation of the FNAB as indicative of malignancy in general and MEC in particular.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15754364.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Gomaa AH, Yaar M, Bhawan J: Cutaneous immunoreactivity of D2-40 antibody beyond the lymphatics. Am J Dermatopathol; 2007 Feb;29(1):18-21

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  • Podoplanin not only is highly expressed in lymphatic endothelium but also in other cell types, including sebaceous carcinoma cells.
  • Using the D2-40 antibody, our purpose was to evaluate expression of podoplanin in sebaceous glands of normal skin.
  • Twenty-four formalin-fixed, paraffin-embedded normal skin specimens (10 from scalp and 14 from cheeks) were immunostained using the D2-40 mouse monoclonal antibody.
  • Strong immunostaining with D2-40 antibody was observed at the periphery of sebaceous glands and in skin lymphatic endothelium of all specimens, demonstrating that podoplanin is expressed in sebaceous glands of normal skin.
  • [MeSH-major] Antibodies, Monoclonal / metabolism. Endothelium, Lymphatic / metabolism. Membrane Glycoproteins / metabolism. Sebaceous Glands / metabolism. Skin / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Carcinoma / metabolism. Carcinoma / pathology. Female. Humans. Male. Middle Aged. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 17284957.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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72. Pakhrin B, Kang MS, Bae IH, Park MS, Jee H, You MH, Kim JH, Yoon BI, Choi YK, Kim DY: Retrospective study of canine cutaneous tumors in Korea. J Vet Sci; 2007 Sep;8(3):229-36
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  • Thirty-eight different types of cutaneous tumors were identified and categorized into epithelial and melanocytic tumors (56.95%), mesenchymal tumors (38.90%), and hematopoietic tumors (4.14%) located in the skin.
  • Among these, 69.25% were benign and 30.74% were malignant.
  • The top ten most frequently diagnosed cutaneous tumors were epidermal and follicular cysts (12.70%), lipoma (11.36%), mast cell tumors (8.82%), cutaneous histiocytoma (7.49%), basal cell tumors (6.82%), sebaceous gland adenoma (6.68%), sebaceous gland hyperplasia (5.08%), hepatoid gland adenoma (3.61%), apocrine adenocarcinoma (3.07%), and fibroma (2.81%), in order of prevalence.
  • [MeSH-major] Dog Diseases / pathology. Skin Neoplasms / veterinary

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  • [Cites] J Vet Med A Physiol Pathol Clin Med. 2002 Mar;49(2):87-91 [11958472.001]
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  • (PMID = 17679768.001).
  • [ISSN] 1229-845X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2868128
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73. Navi D, Wadhera A, Fung MA, Fazel N: Muir-Torre syndrome. Dermatol Online J; 2006;12(5):4
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  • A 65-year-old man with a history of multiple neoplastic and pre-neoplastic gastrointestinal lesions as well as urogenital carcinoma presented for evaluation of two asymptomatic skin-colored papules in the head and neck region.
  • Biopsy revealed sebaceous neoplasms and immunohistochemical staining was negative for the presence of hMSH-2 protein in both specimens.
  • Muir-Torre Syndrome is a rare autosomal dominant genodermatosis associated with mutations in mismatch repair proteins, hMSH-2 and hMLH-1, which predispose affected patients to visceral malignancies as well as sebaceous gland neoplasms.
  • [MeSH-major] Carrier Proteins / genetics. Gastrointestinal Neoplasms / genetics. MutS Homolog 2 Protein / genetics. Nuclear Proteins / genetics. Sebaceous Gland Neoplasms / genetics
  • [MeSH-minor] Adaptor Proteins, Signal Transducing. Adenocarcinoma, Sebaceous / genetics. Adenocarcinoma, Sebaceous / pathology. Adenoma / genetics. Adenoma / pathology. Carcinoma, Squamous Cell / genetics. DNA Repair. Humans. Male. Middle Aged. Mutation. Syndrome

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  • (PMID = 16962019.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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74. Chhibber V, Dresser K, Mahalingam M: MSH-6: extending the reliability of immunohistochemistry as a screening tool in Muir-Torre syndrome. Mod Pathol; 2008 Feb;21(2):159-64
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  • Given this, the aim of the present study was to ascertain the frequency of the same in unselected sebaceous gland neoplasms.
  • Overall, we found that 59% of sebaceous neoplasms exhibited a mutation in at least one mismatch repair protein gene -- a prevalence rate similar to that reported previously by others.
  • [MeSH-major] Adenoma / genetics. DNA-Binding Proteins / genetics. Genetic Testing. Immunohistochemistry / methods. Neoplastic Syndromes, Hereditary / genetics. Sebaceous Gland Neoplasms / genetics

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  • (PMID = 18065960.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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75. Hong HH, Houle CD, Ton TV, Sills RC: K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. Toxicol Pathol; 2007 Jan;35(1):81-5
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  • In 2-year mouse studies, ethylene oxide (EO) induced lung, Harderian gland (HG), and uterine neoplasms.
  • These data show a strong predilection for development of K-ras mutations in EO-induced lung, Harderian gland, and uterine neoplasms.
  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. Carcinogens / toxicity. Ethylene Oxide / toxicity. Genes, ras. Lung Neoplasms / genetics. Sebaceous Gland Neoplasms / genetics. Uterine Neoplasms / genetics
  • [MeSH-minor] Animals. DNA, Neoplasm / analysis. Disinfectants / toxicity. Dose-Response Relationship, Drug. Female. Harderian Gland / drug effects. Harderian Gland / pathology. Inhalation Exposure. Male. Mice. Mice, Inbred Strains. Mutation

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  • (PMID = 17325976.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / DNA, Neoplasm; 0 / Disinfectants; JJH7GNN18P / Ethylene Oxide
  • [Other-IDs] NLM/ NIHMS33464; NLM/ PMC2099306
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76. Kazakov DV, Belousova IE, Bisceglia M, Calonje E, Emberger M, Grayson W, Hantschke M, Kempf W, Kutzner H, Michal M, Spagnolo DV, Virolainen S, Zelger B: Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases. J Am Acad Dermatol; 2007 Sep;57(3):467-83
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  • [Title] Apocrine mixed tumor of the skin ("mixed tumor of the folliculosebaceous-apocrine complex"). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Apocrine Glands. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Differentiation. Child. Epithelium / pathology. Female. Humans. Male. Metaplasia. Middle Aged. Sebaceous Glands / pathology

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  • (PMID = 17707152.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 104
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77. Vernez M, Hutter P, Monnerat C, Halkic N, Gugerli O, Bouzourene H: A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene. Fam Cancer; 2007;6(1):141-5
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  • Muir-Torre syndrome (MTS) is a rare cancer-predisposing syndrome that is autosomal dominantly inherited and characterized by the development of sebaceous skin lesions (adenomas, epitheliomas, basaliomas and carcinomas).
  • [MeSH-major] Cholangiocarcinoma / genetics. Cholangiocarcinoma / secondary. Germ-Line Mutation. Liver Neoplasms / genetics. MutS Homolog 2 Protein / deficiency. Neoplasms, Multiple Primary / genetics. Neoplastic Syndromes, Hereditary / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / surgery. Adenoma / genetics. Adenoma / surgery. Adult. Brain Neoplasms / genetics. Brain Neoplasms / secondary. Brain Neoplasms / surgery. Carcinoma / genetics. Carcinoma / surgery. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / surgery. DNA Mutational Analysis. DNA Probes. DNA-Binding Proteins. Endometrial Neoplasms / surgery. Female. Humans. Microsatellite Instability. Mutation, Missense. Polyps / surgery. Proline / genetics. Sebaceous Gland Neoplasms / genetics. Sebaceous Gland Neoplasms / surgery. Serine / genetics. Syndrome

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  • (PMID = 17051350.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Probes; 0 / DNA-Binding Proteins; 452VLY9402 / Serine; 9DLQ4CIU6V / Proline; EC 3.6.1.3 / MutS Homolog 2 Protein
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78. Schmidt LA, Olsen SH, McHugh JB: Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy. Am J Surg Pathol; 2010 Aug;34(8):1205-10
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  • [Title] Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy.
  • Cutaneous adnexal differentiation is well-recognized in benign mixed tumors occurring in cutaneous sites.
  • The incidence of this histologic finding in salivary gland sites is not known.
  • We sought to describe the incidence of cutaneous adnexal differentiation in benign mixed tumors of the palate, lip, and parotid gland.
  • Benign mixed tumors of the palate (n=30), lip (n=13), and parotid gland (n=37) resected between 1980 and 2009 at a single academic medical institution were reviewed.
  • After confirming the diagnosis of benign mixed tumor, we evaluated for morphologic evidence of cutaneous adnexal differentiation and metaplastic epithelial and stromal changes.
  • Cutaneous adnexal differentiation was seen in 20% of palate and 39% of lip benign mixed tumors but in no parotid tumors.
  • Sebaceous differentiation was seen in only one palate tumor.
  • When cutaneous adnexal differentiation occurs in salivary gland pleomorphic adenomas, it can present a diagnostic pitfall that must not be misinterpreted as carcinoma at biopsy, fine needle aspiration, or frozen section.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Cell Differentiation. Diagnostic Errors / prevention & control. Epithelial Cells / pathology. Mouth Neoplasms / pathology. Stromal Cells / pathology

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  • (PMID = 20661019.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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79. Liu HN, Chang YT, Chen CC, Huang CH: Histopathological and immunohistochemical studies of poroid hidradenoma. Arch Dermatol Res; 2006 Jan;297(7):319-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous differentiation in two PH lesions suggested the possibility of an apocrine origin.
  • [MeSH-major] Adenoma, Sweat Gland / chemistry. Adenoma, Sweat Gland / pathology. Keratins / analysis. Sweat Gland Neoplasms / chemistry. Sweat Gland Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic / pathology. Eccrine Glands / pathology. Epidermis / pathology. Humans. Immunohistochemistry. Male. Melanins / analysis. Middle Aged. Skin Neoplasms / chemistry. Skin Neoplasms / etiology. Skin Neoplasms / pathology

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  • (PMID = 16283345.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Melanins; 68238-35-7 / Keratins
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80. Kiyohara T, Kumakiri M, Kuwahara H, Saitoh A, Ansai S: Rippled-pattern sebaceoma: a report of a lesion on the back with a review of the literature. Am J Dermatopathol; 2006 Oct;28(5):446-8
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  • There were scattered cells showing sebaceous differentiation with vacuolated cytoplasm and scalloped nuclei.
  • The present case is the first reported rippled-pattern sebaceous neoplasm on the back.
  • Many spindle cell tumors, such as basal cell carcinoma, pleomorphic adenoma, dermatofibrosarcoma protuberans, myofibroblastoma, and leiomyoblastoma, in addition to trichoblastoma and sebaceoma, can have a rippled-pattern.
  • [MeSH-major] Back. Hair Follicle / pathology. Neoplasms, Basal Cell / pathology. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 17012924.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
  • [Number-of-references] 23
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81. Donati M, Gandolfo L, Privitera A, Brancato G, Cardi F, Donati A: Superficial parotidectomy as first choice for parotid tumours. Chir Ital; 2007 Jan-Feb;59(1):91-7

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  • Parotid neoplasms represent 3% of all head and neck tumours, and most are benign.
  • At histology, 10 pleomorphic adenomas, 4 Warthin's tumours, 1 lymphoepithelial cyst and 1 sebaceous adenocarcinoma were detected.
  • The capsule appeared breached in only 1 case of pleomorphic adenoma.
  • Superficial parotidectomy seems to be the best choice of treatment for benign parotid tumours, since it allows complete excision of the tumour with sparing of the facial nerve.
  • [MeSH-major] Parotid Neoplasms / surgery. Salivary Gland Fistula / surgery

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  • (PMID = 17361936.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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82. Arnold A, Payne S, Fisher S, Fricker D, Soloway J, White SM, Novelli M, MacDonald K, Mackay J, Groves R, Canham N: An individual with Muir-Torre syndrome found to have a pathogenic MSH6 gene mutation. Fam Cancer; 2007;6(3):317-21
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  • [MeSH-major] Adenocarcinoma / genetics. Adenoma / genetics. DNA-Binding Proteins / genetics. Mutation. Neoplasms, Multiple Primary / genetics. Rectal Neoplasms / genetics. Sebaceous Gland Neoplasms / genetics

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  • (PMID = 17323113.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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83. Misago N, Narisawa Y: Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation. J Dermatol; 2006 Jan;33(1):2-9

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  • [Title] Cytokeratin 15 expression in apocrine mixed tumors of the skin and other benign neoplasms with apocrine differentiation.
  • To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation.
  • All eight cases of AMT of the skin showed CK15 immunostaining of the neoplastic cells, and all four cases of syringocystadenoma papilliferum, all five cases of spiradenoma, and both cases of cylindroma also showed a focally positive reaction to CK15.
  • None of the other benign neoplasms with presumed apocrine differentiation showed CK15 expression.
  • In AMT of the skin, the proportion of CK15-positive cells in the follicular or sebaceous differentiation group (78.8%, average of four cases) was significantly higher than the group without this differentiation (8.8%, average of four cases).
  • AMT of the skin are unique among benign neoplasms with apocrine differentiation in their substantial and constant CK15 expression, suggesting that they derive from multipotent epithelial stem cells in the bulge.
  • AMT of the skin with follicular or sebaceous differentiation are considered to show an immature stage of apocrine differentiation still rich in stem cells or to originate from stem cells with an incompletely established apocrine fate.
  • [MeSH-major] Apocrine Glands / metabolism. Keratins / metabolism. Sweat Gland Neoplasms / metabolism
  • [MeSH-minor] Adenoma, Sweat Gland / metabolism. Adult. Aged. Biomarkers, Tumor. Case-Control Studies. Cystadenoma / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16469077.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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84. Zhang S, Bao R, Bagby J, Abreo F: Fine needle aspiration of salivary glands: 5-year experience from a single academic center. Acta Cytol; 2009 Jul-Aug;53(4):375-82
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  • STUDY DESIGN: A total of 191 salivary gland FNAs were performed at Louisiana State University Health Science Center from 2003 to 2007, and all were done on major salivary glands except for 1 case.
  • The only false positive was a pleomorphic adenoma misdiagnosed as adenoid cystic carcinoma.
  • Four reactive processes were diagnosed as benign neoplasms, including 2 granulomatous inflammation and 2 chronic sialadenitis.
  • Five benign neoplasms were interpreted as reactive processes, including 2 Warthin's tumors, 2 sebaceous lymphoadenomas and 1 pleomorphic adenoma.
  • The overall accuracy in distinguishing benign from malignant lesions was 79.1%, and the sensitivity for salivary neoplasia was 89.4%.
  • CONCLUSION: Our results are consistent with the literature that salivary gland FNA has good sensitivity, specificity and accuracy in the diagnosis of salivary neoplasms.
  • [MeSH-major] Biopsy, Fine-Needle. Salivary Gland Diseases / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • (PMID = 19697720.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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85. Kazakov DV, Mukensnabl P, Michal M: An unusual hamartoma of the folliculosebaceous-apocrine unit: a case report. J Cutan Pathol; 2006 May;33(5):365-8
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  • The patient obviously had no skin problems afterwards; her 12-year follow-up was significant for leucopenia and nephrolithiasis.
  • Some of the epithelial structures were reminiscent of those seen in tubular apocrine adenoma; others resembled syringomatous elements.
  • [MeSH-major] Apocrine Glands / pathology. Hair Follicle / pathology. Hamartoma / pathology. Sebaceous Gland Diseases / pathology. Skin Diseases / pathology

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  • (PMID = 16640544.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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86. Abdulla AN, Covert AA, Grantmyre JE: Scrotal syringocystadenoma papilliferum: case report. Can J Urol; 2009 Jun;16(3):4684-6
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  • Syringocystadenoma papilliferum (SCAP) is a benign rare adnexal skin neoplasm, which in a third of cases arises from a nevus sebaceous and is most commonly found on the head and neck and in very rare instances found on the genitalia.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Scrotum / pathology. Skin Neoplasms / pathology. Syringoma / pathology

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  • (PMID = 19497181.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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87. Villalón G, Monteagudo C, Martín JM, Ramón D, Alonso V, Jordá E: [Chondroid syringoma: a clinical and histological review of eight cases]. Actas Dermosifiliogr; 2006 Nov;97(9):573-7
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  • INTRODUCTION: Chondroid syringoma is a rare skin tumor that presents as a slow growing, indolent lesion, that is more frequent in male adults and is usually benign.
  • Five of the eight cases were apocrine, one of them with follicular and sebaceous differentiation.
  • DISCUSSION: The chondroid syringoma is usually a small-sized skin tumor, frequently on the head and neck.
  • As a general rule, it is a benign tumor.
  • Some authors have proposed the term of atypical mixed tumor of the skin for those chondroid syringomas with histological traits of malignancy but without evidence of metastasis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17173760.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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88. Premalata CS, Kumar RV, Malathi M, Shenoy AM, Nanjundappa N: Cutaneous leiomyosarcoma, trichoblastoma, and syringocystadenoma papilliferum arising from nevus sebaceus. Int J Dermatol; 2007 Mar;46(3):306-8
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  • The specimen of the initial surgery consisted of skin-covered tissue with an exophytic firm growth measuring 6 x 5 x 4 cm.
  • The skin surface was rough with areas of ulceration.
  • The third lesion was a spindle cell sarcoma which formed the major part of the lesion, diffusely infiltrating the dermis and subcutaneous tissue, elevating and ulcerating the overlying skin.
  • A small area of epidermal hyperplasia with acanthosis and papillomatosis overlying malformed highly placed sebaceous glands was the only evidence of a pre-existing nevus sebaceus.
  • The wide excision specimen of the recurrent swelling consisted of a skin-covered nodule with ulceration, measuring 3 x 4 x 3 cm, with a gray-white whorled cut surface.
  • Multiple sections showed only spindle cell sarcoma infiltrating the skin and subcutaneous tissue, morphologically similar to the earlier tumor, with ulceration of the overlying skin.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Head and Neck Neoplasms / pathology. Leiomyosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Nevus / pathology. Scalp. Skin Neoplasms / pathology. Sweat Gland Neoplasms / pathology


89. Mukaratirwa S, Chipunza J, Chitanga S, Chimonyo M, Bhebhe E: Canine cutaneous neoplasms: prevalence and influence of age, sex and site on the presence and potential malignancy of cutaneous neoplasms in dogs from Zimbabwe. J S Afr Vet Assoc; 2005 Jun;76(2):59-62
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  • Histopathological examination was performed on cutaneous biopsies from 900 dogs with skin lesions from Zimbabwe, collected from 1996 to 2000.
  • The 10 most common tumours, comprising 73.7% of all cutaneous neoplasms, were mast cell tumours, squamous cell carcinomas, perianal gland adenomas, lymphomas, benign melanomas, haemangiosarcomas, sebaceous gland adenomas, fibrosarcomas, lipomas and malignant melanomas.
  • [MeSH-major] Dog Diseases / epidemiology. Dog Diseases / pathology. Skin Neoplasms / veterinary
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / pathology. Adenoma / veterinary. Age Factors. Animals. Dogs. Female. Lipoma / epidemiology. Lipoma / pathology. Lipoma / veterinary. Male. Melanoma / epidemiology. Melanoma / pathology. Melanoma / veterinary. Prevalence. Risk Factors. Sarcoma / epidemiology. Sarcoma / pathology. Sarcoma / veterinary. Sex Factors. Zimbabwe / epidemiology

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  • (PMID = 16108522.001).
  • [ISSN] 1019-9128
  • [Journal-full-title] Journal of the South African Veterinary Association
  • [ISO-abbreviation] J S Afr Vet Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] South Africa
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90. Bacha D, Deschamps L, Sauvanet A, Couvelard A: [Muir-Torre syndrome: rare association with duodenal carcinoma]. Ann Pathol; 2009 Dec;29(6):495-8
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  • Muir-Torre syndrome, a rare autosomal dominant inherited disease, is characterized by the synchronous or metachronous occurrence of at least one sebaceous gland neoplasia such as an adenoma or carcinoma, with or without keratoacanthoma, and at least one internal malignancy, mostly colorectal cancer.

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  • (PMID = 20005439.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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91. Kazakov DV, Sima R, Vanecek T, Kutzner H, Palmedo G, Kacerovska D, Grossmann P, Michal M: Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol; 2009 May;31(3):248-55
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  • DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene.
  • [MeSH-major] Exons. Mutation. Neoplasms, Adnexal and Skin Appendage / genetics. Skin Neoplasms / genetics. beta Catenin / genetics

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  • (PMID = 19384065.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
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92. Honeycutt KA, Waikel RL, Koster MI, Wang XJ, Roop DR: The effect of c-myc on stem cell fate influences skin tumor phenotype. Mol Carcinog; 2010 Apr;49(4):315-9
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  • [Title] The effect of c-myc on stem cell fate influences skin tumor phenotype.
  • Nonmelanoma skin cancers (NMSCs) consist of a variety of tumor types including basal cell carcinoma, squamous cell carcinoma, a variety of hair follicle tumors, and sebaceous gland tumors.
  • These mice exhibited an increase in size and number of sebaceous glands, suggesting that c-myc diverted multipotential stem cells to a sebaceous lineage.
  • To this end, we exposed K14.MYC2 mice to a chemical carcinogenesis protocol and discovered that these mice were predisposed to develop sebaceous adenomas.
  • [MeSH-major] Proto-Oncogene Proteins c-myc / genetics. Skin Neoplasms / genetics. Skin Neoplasms / pathology. Stem Cells / pathology
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene / toxicity. Adenocarcinoma, Sebaceous / pathology. Animals. Carcinogens / toxicity. Cell Differentiation / genetics. Cell Lineage / genetics. Crosses, Genetic. Female. Heterozygote. Male. Mice. Mice, Inbred ICR. Mice, Inbred Strains. Mice, Transgenic. Multipotent Stem Cells / pathology. Papilloma / pathology. Phenotype. Sebaceous Gland Neoplasms / pathology. Tetradecanoylphorbol Acetate / pharmacology. Transgenes

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  • (PMID = 20146250.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR47898; United States / NCI NIH HHS / CA / CA09197; United States / NCI NIH HHS / CA / CA105491; United States / NCI NIH HHS / CA / CA52607; United States / NCI NIH HHS / CA / CA79998
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Proto-Oncogene Proteins c-myc; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; NI40JAQ945 / Tetradecanoylphorbol Acetate
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93. Rammeh-Rommani S, Fezaa B, Chelbi E, Kammoun MR, Ben Jilani SB, Zermani R: Syringocystadenoma papilliferum: report of 8 cases. Pathologica; 2006 Jun;98(3):178-80
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  • It arises in about one third of cases within a sebaceous hamartoma (SH) and in this case, multiple other benign adnexal neoplasms may be associated with it.
  • [MeSH-major] Adenoma, Sweat Gland / pathology. Sweat Gland Neoplasms / pathology

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  • (PMID = 17036946.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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94. Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C: Activator protein-1 activity regulates epithelial tumor cell identity. Cancer Res; 2006 Aug 1;66(15):7578-88
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  • To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in skin, transgenic mice were generated, which use the tetracycline system to conditionally express A-FOS, a dominant negative that inhibits AP-1 DNA binding.
  • Older mice develop mild alopecia and hyperplasia of sebaceous glands, particularly around the eyes.
  • When A-FOS was expressed during chemical-induced skin carcinogenesis, mice do not develop characteristic benign and malignant squamous lesions but instead develop benign sebaceous adenomas containing a signature mutation in the H-ras proto-oncogene.
  • Inhibiting AP-1 activity after tumor formation caused squamous tumors to transdifferentiate into sebaceous tumors.
  • Furthermore, reactivating AP-1 in sebaceous tumors results in a reciprocal transdifferentiation into squamous tumors.
  • Molecular characterization of cultured keratinocytes and tumor material indicates that AP-1 regulates the balance between the wnt/beta-catenin and hedgehog signaling pathways that determine squamous and sebaceous lineages, respectively.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Carcinoma, Squamous Cell / metabolism. Skin Neoplasms / metabolism. Transcription Factor AP-1 / metabolism
  • [MeSH-minor] Animals. DNA, Neoplasm / metabolism. Hyperplasia. Keratinocytes / metabolism. Mice. Mice, Transgenic. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Promoter Regions, Genetic. Protein Binding. Proto-Oncogene Proteins c-fos / biosynthesis. Proto-Oncogene Proteins c-fos / genetics. Proto-Oncogene Proteins c-jun / metabolism. Sebaceous Glands / pathology. Transcriptional Activation. Wnt Proteins / genetics


95. NTP technical report on the toxicology and carcinogenesis studies of 1,2-dibromo-2,4-dicyanobutane (CAS No. 35691-65-7) in F344/N rats and B6C3F1 mice (dermal studies). Natl Toxicol Program Tech Rep Ser; 2010 Jun;(555):1-171
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  • Irritation, thickened skin, and ulcers were observed at the site of application in most dosed males and females.
  • The thyroid gland weights of males administered 600 mg/kg were significantly less than those of the vehicle controls.
  • A spectrum of nonneoplastic lesions including epidermal hyperplasia and hyperkeratosis, sebaceous gland hyperplasia, and dermal chronic active inflammation occurred at the site of application in all dosed groups of rats.
  • Irritation, thickened skin, and ulcers were observed at the site of application in dosed mice.
  • Skin lesions at the site of application including epidermal hyperplasia, hyperkeratosis, parakeratosis, necrosis, and ulcers; dermal chronic active inflammation; and sebaceous gland hyperplasia occurred in all dosed groups of mice.
  • In the dermis at the site of application, the incidences of chronic active inflammation in 6 and 18 mg/kg males and females administered 2 mg/kg or greater and sebaceous gland hyperplasia in males administered 6 or 18 mg/kg were significantly increased.
  • The incidences of sebaceous gland hyperplasia at the site of application were significantly increased in males and females administered 6 or 18 mg/kg.
  • The combined incidence of mammary gland fibroadenoma, adenoma, or adenocarcinoma occurred with a negative trend, and the incidence was significantly decreased in 6 mg/kg female rats.
  • [MeSH-minor] Animals. Carcinogenicity Tests. Dose-Response Relationship, Drug. Female. Male. Mice. Mice, Inbred Strains. Mutagenicity Tests. Organ Size / drug effects. Rats. Rats, Inbred F344. Skin / drug effects. Skin / pathology

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  • (PMID = 20725155.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nitriles; YX089CPS05 / 1,2-dibromo-2,4-dicyanobutane
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96. Seethala RR, Barnes EL, Hunt JL: Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol; 2007 Jan;31(1):44-57
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  • However, new morphologies in EMCa such as ancient change (8.2%), "Verocay"-like change (3.3%), and sebaceous differentiation (13.1%) were noted.
  • Specific histologic variants were dedifferentiated EMCa (3.3%), oncocytic EMCa (8.2%), EMCa ex pleomorphic adenoma (1.6%), double-clear EMCa (3.3%), and EMCa with myoepithelial anaplasia (3.3%).
  • Thus, EMCa is generally a low-grade tumor with a broader morphologic spectrum than previously thought, with several key features predictive of recurrence.
  • [MeSH-major] Carcinoma / secondary. Mixed Tumor, Malignant / secondary. Myoepithelioma / secondary. Salivary Gland Neoplasms / pathology. Stomatognathic System / pathology


97. Ostler DA, Prieto VG, Reed JA, Deavers MT, Lazar AJ, Ivan D: Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol; 2010 Apr;23(4):567-73
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  • [Title] Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases.
  • Adipophilin is a monoclonal antibody against a protein on the surface of intracellular lipid droplets, and it was recently shown to be expressed in sebocytes and sebaceous lesions.
  • This study examines adipophilin expression in various sebaceous lesions and other cutaneous tumors with a clear cell histology that may mimic sebaceous differentiation.
  • A total of 117 cutaneous clear cell lesions including 16 sebaceous adenomas, 25 sebaceous carcinomas, 8 basal cell carcinomas, 12 squamous cell carcinomas, 6 xanthomas, 10 xanthelasmas, 10 xanthogranulomas, 4 balloon cell nevi, 5 trichilemmomas, 8 clear cell hidradenomas, and 13 metastatic renal cell carcinomas were examined using immunohistochemistry for the expression of adipophilin.
  • Adipophilin was expressed in 16 of 16 (100%) sebaceous adenomas, 23 of 25 (92%) sebaceous carcinomas, 10 of 10 (100%) xanthelasmas, 9 of 10 (90%) xanthogranulomas, 6 of 6 (100%) xanthomas, and 9 of 13 (62.5%) metastatic renal cell carcinomas.
  • The characteristic staining pattern differed between sebaceous and non-sebaceous tumors with the former showing a membranous vesicular pattern and the latter being more granular.
  • Adipophilin can be valuable in an immunohistochemical panel when evaluating cutaneous lesions with clear cell histology as it identifies intracytoplasmic lipid vesicles in sebaceous and xanthomatous lesions.
  • In periocular lesions, it is effective in helping to exclude basal cell carcinoma and squamous cell carcinoma when sebaceous carcinoma is under consideration.
  • [MeSH-major] Biomarkers, Tumor / analysis. Peptides / metabolism. Sebaceous Gland Neoplasms / metabolism. Sebaceous Gland Neoplasms / pathology. Skin Neoplasms / metabolism. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Immunohistochemistry. Infant. Male. Membrane Proteins. Middle Aged. Neoplasms, Adnexal and Skin Appendage / metabolism. Neoplasms, Adnexal and Skin Appendage / pathology. Young Adult

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  • (PMID = 20118912.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / Peptides; 0 / perilipin 2
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98. Katona TM, Billings SD, Montironi R, Lopez-Beltran A, Cheng L: Expression of OCT4 transcription factor in cutaneous neoplasia. Appl Immunohistochem Mol Morphol; 2007 Dec;15(4):359-62
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  • We have examined a series of basal cell carcinomas and adnexal tumors of related histogenesis, in an effort to corroborate the above findings and to assess for expression of OCT4 protein in neoplasia of the infundibulo-apocrine-sebaceous unit.
  • We analyzed OCT4 expression in 115 cutaneous specimens including 26 basal cell carcinomas, 12 benign follicular tumors (10 trichoepitheliomas and 2 trichoblastomas), 10 benign apocrine tumors, 12 sebaceous hyperplasia lesions, 10 sebaceous adenomas, 4 sebaceous carcinomas, 13 nevi sebacei of Jadassohn, 8 squamous cell carcinomas (including one spindle-cell squamous cell carcinoma), 8 compound melanocytic nevi, 5 Merkel cell carcinomas, 3 pilar cysts, 1 scar, 2 nonspecific, mild superficial perivascular dermatitis specimens, and 1 non-scarring alopecia.

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  • (PMID = 18091376.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human
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99. Perna AG, Ostler DA, Ivan D, Lazar AJ, Diwan AH, Prieto VG, Reed JA: Renal cell carcinoma marker (RCC-Ma) is specific for cutaneous metastasis of renal cell carcinoma. J Cutan Pathol; 2007 May;34(5):381-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: One hundred and thirty-seven cutaneous clear cell lesions including eight xanthomas, 32 xanthelasmas, 25 xanthogranulomas, seven balloon cell nevi, six clear cell hidradenomas, 29 sebaceous adenomas, six sebaceous epitheliomas, eight sebaceous carcinomas, and 16 MRCC were examined using immunohistochemistry for the expression of RCC-Ma.
  • [MeSH-major] Antibodies, Monoclonal. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 17448192.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor
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100. Singh AD, Mudhar HS, Bhola R, Rundle PA, Rennie IG: Sebaceous adenoma of the eyelid in Muir-Torre syndrome. Arch Ophthalmol; 2005 Apr;123(4):562-5
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  • [Title] Sebaceous adenoma of the eyelid in Muir-Torre syndrome.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Eyelid Neoplasms / pathology. Gastrointestinal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Sebaceous Gland Neoplasms / pathology

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  • (PMID = 15824235.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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