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Items 1 to 100 of about 405
1. Farag M, Saklani A, N NN, Masoud A: The Red Rectum (Carpet villous adenoma of the rectum). J Surg Case Rep; 2010;2010(10):10

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  • [Title] The Red Rectum (Carpet villous adenoma of the rectum).
  • Carpeted villous adenomas of rectum may be extensive and not suitable for transanal excision or Endoscopic mucosal resection.

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  • [Copyright] © JSCR.
  • (PMID = 24945847.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649181
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2. Sinha R, Peters U, Cross AJ, Kulldorff M, Weissfeld JL, Pinsky PF, Rothman N, Hayes RB: Meat, meat cooking methods and preservation, and risk for colorectal adenoma. Cancer Res; 2005 Sep 1;65(17):8034-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
  • We investigated meat, processed meat, HCAs, and the PAH benzo(a)pyrene and the risk of colorectal adenoma in 3,696 left-sided (descending and sigmoid colon and rectum) adenoma cases and 34,817 endoscopy-negative controls.
  • Intake of red meat, with known doneness/cooking methods, was associated with an increased risk of adenoma in the descending and sigmoid colon [odds ratio (OR), 1.26; 95% confidence interval (95% CI), 1.05-1.50 comparing extreme quintiles of intake] but not rectal adenoma.
  • Well-done red meat was associated with increased risk of colorectal adenoma (OR, 1.21; 95% CI, 1.06-1.37).
  • Increased risks for adenoma of the descending colon and sigmoid colon were observed for the two HCAs: 2-amino-3,8-dimethylimidazo[4,5]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine (OR, 1.18; 95% CI, 1.01-1.38 and OR, 1.17, 95% CI, 1.01-1.35, respectively) as well as benzo(a)pyrene (OR, 1.18; 95% CI, 1.02-1.35).
  • Greater intake of bacon and sausage was associated with increased colorectal adenoma risk (OR, 1.14; 95% CI, 1.00-1.30); however, total intake of processed meat was not (OR, 1.04; 95% CI, 0.90-1.19).
  • Our study of screening-detected colorectal adenomas shows that red meat and meat cooked at high temperatures are associated with an increased risk of colorectal adenoma.
  • [MeSH-major] Adenoma / etiology. Colorectal Neoplasms / etiology. Cooking. Food Preservation. Meat

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  • (PMID = 16140978.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Imidazoles; 0 / Mutagens; 0 / Quinoxalines; 3417WMA06D / Benzo(a)pyrene; 77500-04-0 / 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; 909C6UN66T / 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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3. Røkke O, Faerden AE, Øvrebø K: [Transanal endoscopic microsurgery for tumours in rectum]. Tidsskr Nor Laegeforen; 2007 Nov 15;127(22):2954-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Transanal endoscopic microsurgery for tumours in rectum].
  • [Transliterated title] Transanal endoskopisk mikrokirurgi ved svulster i rectum.
  • BACKGROUND: Rectal tumors up to 25 cm from the anal verge may be resected by transanal endoscopic microsurgery (TEM).
  • RESULTS: TEM is a safe and suitable method for resection of rectal adenomas that cannot be radically removed by endoscopic methods.
  • INTERPRETATION: Tumours can be resected in the entire rectum with TEM.
  • Depending on selection criteria and combination with radiotherapy, the method may be suitable for 30 - 110 patients/year with rectal cancer in Norway.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 18026244.001).
  • [ISSN] 0807-7096
  • [Journal-full-title] Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
  • [ISO-abbreviation] Tidsskr. Nor. Laegeforen.
  • [Language] nor
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 50
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4. Sierra-Montenegro E, Rocha-Ramírez JL, Villaneuva-Sáenz E, de la Serna-Ortiz I, Fernández-Rivero JM, Soto-Quirino R: [Villous adenoma of the rectum with severe hydroelectric alterations. Report of two cases]. Cir Cir; 2007 Sep-Oct;75(5):377-9
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  • [Title] [Villous adenoma of the rectum with severe hydroelectric alterations. Report of two cases].
  • [Transliterated title] Adenoma velloso de recto con alteración hidroelectrolítica severa. Informe de dos casos.
  • We report two cases with villous adenoma that presented hydroelectrolytic depletion with clinical and surgical management, exclusively.
  • Upon rectal exam we found a sessile, exophitic soft tumor with irregular surface of approximately 10 cm in diameter.
  • We also performed a transanal resection of tumor reporting villous adenoma.
  • During the rectal exam we identified a sessile, polypoid, 5-cm diameter tumor that did not involve deep planes.
  • CONCLUSIONS: Size and location of the villous adenoma are related to the production of mucus secretory diarrhea.
  • In every patient with presence of mucus, persistent diarrhea and occasional rectal bleeding of 1 month, it is necessary to carry out lower endoscopy to rule out the presence of villous adenoma.
  • [MeSH-major] Adenoma, Villous / complications. Rectal Neoplasms / complications. Water-Electrolyte Imbalance / etiology

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  • (PMID = 18158885.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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5. Antillon MR, Bartalos CR, Miller ML, Diaz-Arias AA, Ibdah JA, Marshall JB: En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video). Gastrointest Endosc; 2008 Feb;67(2):332-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video).
  • OBJECTIVE: To show the feasibility of ESD to remove en bloc, very large LSTs of the rectum, even when there is involvement to the dentate line.
  • PATIENTS: A 53-year-old patient, with a 14-cm tubulovillous adenoma of the rectum, which, at its maximal extent, involved two thirds of the circumference of the rectum.
  • CONCLUSIONS: This case demonstrated the feasibility of using ESD to remove large laterally spreading rectal tumors, including when there was involvement to the dentate line (and the dissection line must include squamous mucosa of the anal canal).
  • [MeSH-major] Adenoma / surgery. Anal Canal / pathology. Electrocoagulation / methods. Rectal Neoplasms / surgery. Thoracoscopy / methods

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  • (PMID = 18226698.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Rousset P, Hoeffel C: [Tumors of the rectum: MRI and CT features]. J Radiol; 2007 Nov;88(11 Pt 1):1679-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Tumors of the rectum: MRI and CT features].
  • [Transliterated title] Tumeurs du rectum: aspects IRM et scanner.
  • The imaging features of rectal tumors on CT and MRI are reviewed.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Adenoma, Villous / diagnosis. Adenoma, Villous / radiography. Magnetic Resonance Imaging / methods. Rectal Neoplasms / diagnosis. Rectal Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Anus Neoplasms / diagnosis. Anus Neoplasms / radiography. Carcinoid Tumor / diagnosis. Carcinoid Tumor / radiography. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / radiography. Diagnosis, Differential. Female. Gastrointestinal Stromal Tumors / diagnosis. Gastrointestinal Stromal Tumors / radiography. Hemangioma, Cavernous / diagnosis. Hemangioma, Cavernous / radiography. Humans. Leiomyoma / diagnosis. Leiomyoma / radiography. Lymphoma / diagnosis. Lymphoma / radiography. Male. Melanoma / diagnosis. Melanoma / radiography. Middle Aged. Neoplasm Staging. Rectum / pathology

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  • (PMID = 18065927.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 12
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7. Kuratate S, Inoue S, Chikakiyo M, Kaneda Y, Harino Y, Hirose T, Yagi T, Saitoh S, Sumitomo M, Fujino R, Satake N: Coexistent poorly-differentiated neuroendocrine cell carcinoma and non-invasive well-differentiated adenocarcinoma in tubulovillous adenoma of the rectum: report of a case. J Med Invest; 2010 Aug;57(3-4):338-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistent poorly-differentiated neuroendocrine cell carcinoma and non-invasive well-differentiated adenocarcinoma in tubulovillous adenoma of the rectum: report of a case.
  • A 74-years old man was referred to our hospital for treatment of a rectal mass.
  • Colonoscopy revealed villous tumor covering all the lower rectal lumen.
  • Biopsy yielded a diagnosis of adenoma.
  • CT examination showed tumor shadows of the rectum and the liver.
  • Pelvic MRI examination showed a 10.5×8×7 cm tumor with high signal intensity on the T2 weighted images in the rectum.
  • Rectosigmoidectomy with lymph node dissection was performed with the diagnosis of rectal cancer that metastasized to the liver.
  • Histological and immuno- histochemical features showed coexistent poorly-differentiated small cell neuroendocrine cell (NEC) carcinoma and non-invasive well-differentiated adenocarcinoma in tubulovillous adenoma.
  • Rectal poorly-differentiated NEC carcinomas are thought to be a tumor with a high malignant potential.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Carcinoma, Neuroendocrine / pathology. Neoplasms, Multiple Primary / pathology. Rectal Neoplasms / pathology

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  • (PMID = 20847536.001).
  • [ISSN] 1349-6867
  • [Journal-full-title] The journal of medical investigation : JMI
  • [ISO-abbreviation] J. Med. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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8. Bretagnol F, Panis Y: [Management of large villous tumors of the lower part of the rectum]. Gastroenterol Clin Biol; 2009 Oct;33(10-11 Suppl):F101-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of large villous tumors of the lower part of the rectum].
  • [Transliterated title] Comment prendre en charge une tumeur villeuse étendue du bas rectum?
  • Radical surgery (i.e. rectal resection) remains the gold standard for surgical management of large villous tumours but such a strategy is associated with potential postoperative complications with high risk of functional disorders and genito-urinary dysfunction.
  • A new procedure as transanal endoscopic microsurgery can be proposed to achieve local complete excision of rectal tumours especially in the middle and upper parts of the rectum lesions unresectable by conventional local surgery.
  • [MeSH-major] Adenoma, Villous / pathology. Adenoma, Villous / surgery. Microsurgery. Proctoscopy. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery

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  • (PMID = 19748196.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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9. Cho SD, Herzig DO, Douthit MA, Deveney KE: Treatment strategies and outcomes for rectal villous adenoma from a single-center experience. Arch Surg; 2008 Sep;143(9):866-70; discussion 871-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment strategies and outcomes for rectal villous adenoma from a single-center experience.
  • OBJECTIVES: To analyze a 13-year, single-surgeon experience with villous adenoma of the rectum with respect to procedure, complications, recurrence, and cancer incidence.
  • PATIENTS: Patients who underwent excision of rectal villous adenoma.
  • CONCLUSIONS: Complete excision is warranted for rectal villous adenomas, as biopsies were accurate only 50% of the time, and 1 in 8 patients had unsuspected cancer found after excision.
  • [MeSH-major] Adenoma, Villous / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18794424.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Malmstrøm ML, Meisner S: [Endoscopic mucosal resection of the colon and rectum]. Ugeskr Laeger; 2008 May 12;170(20):1738-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Endoscopic mucosal resection of the colon and rectum].
  • [Transliterated title] Endoskopisk mucosaresektion i colon og rectum.
  • This paper focuses on lesions of the colon and rectum, presenting the method, techniques, instruments and complications.
  • [MeSH-major] Colon / surgery. Colonoscopy / methods. Colorectal Neoplasms / surgery. Intestinal Mucosa / surgery. Minimally Invasive Surgical Procedures / methods. Proctoscopy / methods. Rectum / surgery
  • [MeSH-minor] Adenoma / surgery. Carcinoma / surgery. Humans

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  • (PMID = 18489888.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
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11. Terkivatan T, den Hoed PT, Lange JF Jr, Koot VC, van Goch JJ, Veen HF: The place of the posterior surgical approach for lesions of the rectum. Dig Surg; 2005;22(1-2):86-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The place of the posterior surgical approach for lesions of the rectum.
  • BACKGROUND: Although there are many advantages of a posterior approach to rectal disease, these procedures are not widely accepted because many surgeons fear the postoperative complications.
  • METHODS: The medical records were reviewed of 57 patients who underwent a posterior approach to the rectum between January 1980 and December 2002.
  • Indications for surgery were benign lesions (n = 33), e.g. villous adenoma, rectal prolapse and endometriosis as well as invasive adenocarcinoma (n = 24).
  • During a mean follow-up of 29 (range 2-86) months, 3 patients with a villous adenoma and 2 patients who were treated for a malignant lesion had a locally recurrent lesion.
  • CONCLUSION: We believe that a posterior approach to the rectum should be considered for various benign and selected malignant diseases, especially in case of elderly patients or patients with a compromised general condition, and has to be a part of the surgeon's armamentarium.
  • [MeSH-major] Digestive System Surgical Procedures. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenoma, Villous / surgery. Aged. Aged, 80 and over. Endometriosis / surgery. Female. Humans. Male. Middle Aged. Prolapse. Rectal Diseases / surgery

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  • (PMID = 15849468.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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12. Khoo RE: Transanal excision of a rectal adenoma using single-access laparoscopic port. Dis Colon Rectum; 2010 Jul;53(7):1078-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal excision of a rectal adenoma using single-access laparoscopic port.
  • Many rectal tumors can be excised transanally using inexpensive equipment.
  • Through this port, insufflation with gas maintained exposure of the surgical site, a 30-degree 5-mm camera, a grasper, and electrocautery were used to remove a large villous adenoma.
  • [MeSH-major] Adenoma, Villous / surgery. Colectomy / methods. Laparoscopes. Laparoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 20551763.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Popescu A, Orban-Schiopu AM, Becheanu G, Diculescu M: McKittrick-Wheelock syndrome - a rare cause of acute renal failure. Rom J Gastroenterol; 2005 Mar;14(1):63-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: Fluid and electrolyte hypersecretion in the villous adenoma of the rectum is presented in the case of a 74 year old man presenting with a severe fluid imbalance.
  • At sigmoidoscopy, a 6/4 cm villous adenoma of the rectum was found.
  • The surgical removal of the adenoma led to complete recovery of the symptoms.
  • [MeSH-major] Acute Kidney Injury / etiology. Adenoma / complications. Rectal Neoplasms / complications

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  • (PMID = 15800695.001).
  • [ISSN] 1221-4167
  • [Journal-full-title] Romanian journal of gastroenterology
  • [ISO-abbreviation] Rom J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Electrolytes
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14. Oh K, Willett WC, Fuchs CS, Giovannucci E: Dietary marine n-3 fatty acids in relation to risk of distal colorectal adenoma in women. Cancer Epidemiol Biomarkers Prev; 2005 Apr;14(4):835-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dietary marine n-3 fatty acids in relation to risk of distal colorectal adenoma in women.
  • Epidemiologic studies of dietary marine n-3 fatty acids and risk of colorectal cancer have been inconsistent, and their relation to risk of colorectal adenoma has not been evaluated in detail.
  • We examined dietary marine n-3 fatty acids and the ratio of marine n-3 to total n-6 fatty acids (n-3/n-6 ratio) in relation to risk of adenoma of the distal colon or rectum among 34,451 U.S. women who were initially free of colorectal cancer or polyps, who completed a semiquantitative food frequency questionnaire in 1980, and who underwent endoscopy from 1980 to 1998.
  • We documented 1,719 distal colorectal adenoma cases (705 large adenomas, 897 small adenomas, 1,280 distal colon adenomas, and 505 rectal adenomas) during 18 years of follow-up.
  • Neither dietary marine n-3 fatty acids nor n-3/n-6 ratio were associated with risk of total distal colorectal adenoma after adjustment for age and established risk factors [multivariable relative risk (RR) for extreme quintiles of dietary marine n-3 fatty acids = 1.04; 95% confidence interval (95% CI), 0.84-1.27, P(trend) = 0.66; RR for extreme quintiles of n-3/n-6 ratio = 1.02; 95% CI, 0.83-1.25; P(trend) = 0.86].
  • Similarly, no significant associations were observed separately for distal colon or rectal adenoma.
  • However, higher intake of dietary marine n-3 fatty acids was nonsignificantly but suggestively inversely associated with large adenoma (RR, 0.74; 95% CI, 0.54-1.01; P(trend) = 0.16) but directly associated with small adenoma (RR, 1.36; 95% CI, 1.02-1.81; P(trend) = 0.09).
  • Our findings do not support the hypothesis that a higher intake of marine n-3 fatty acids or a higher n-3/n-6 ratio reduces the risk of distal colorectal adenoma but are suggestive that higher intake may reduce the progression of small adenomas to large adenomas.
  • [MeSH-major] Adenoma / prevention & control. Colorectal Neoplasms / prevention & control. Diet. Fatty Acids, Omega-3 / therapeutic use

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  • [CommentIn] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):406-7 [16492940.001]
  • (PMID = 15824153.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 87969; United States / NCI NIH HHS / CA / CA55075
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids, Omega-3; 0 / Fatty Acids, Omega-6; 0RBV727H71 / alpha-Linolenic Acid
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15. Casadesus D: Surgical resection of rectal adenoma: a rapid review. World J Gastroenterol; 2009 Aug 21;15(31):3851-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical resection of rectal adenoma: a rapid review.
  • TE is limited to the lower rectum, TEM offers better access to lesions in the middle and upper rectum, and ETAR is used less frequently than it deserves for resection of rectal lesions.
  • [MeSH-major] Adenoma. Anastomosis, Surgical. Rectal Neoplasms
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / surgery. Digestive System Surgical Procedures / adverse effects. Digestive System Surgical Procedures / methods. Endoscopy / methods. Humans. Microsurgery / methods. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Rectum / pathology. Rectum / surgery

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  • (PMID = 19701964.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 41
  • [Other-IDs] NLM/ PMC2731246
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16. Piana S, Asioli S, Foroni M: Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features. Virchows Arch; 2006 Feb;448(2):228-31
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  • [Title] Oncocytic adenocarcinoma of the rectum arising on a villous adenoma with oncocytic features.
  • Rectal adenocarcinoma with diffuse oncocytic features is a very rare lesion, having been reported only once in the English literature.
  • We describe a case of oncocytic adenocarcinoma of the rectum, associated with a villous adenoma, arising on a 66-year-old man.
  • On histological examination, the adenocarcinoma was composed of neoplastic glands lined by a strongly eosinophilic, granular epithelium that deeply infiltrated the rectal wall.
  • Superficially, a villous adenoma with high-grade dysplasia was evident; adenomatous cells showed focal eosinophilic changes, consisting of a large granular cytoplasm, an oval atypical nucleus, and a prominent nucleolus.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16450120.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Carcinoembryonic Antigen; 0 / Homeodomain Proteins; 0 / Keratin-20; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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17. Vieth M, Kushima R, de Jonge JP, Borchard F, Oellig F, Stolte M: Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum. Virchows Arch; 2005 May;446(5):542-5

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  • [Title] Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum.
  • In a 46-year-old man, a pedunculated rectal polyp measuring 3.0x3.0x2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa.
  • Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb.
  • The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.
  • [MeSH-major] Adenoma / pathology. Choristoma. Gastric Mucosa. Intestinal Polyps / pathology. Rectal Neoplasms / pathology

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  • (PMID = 15838648.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-6; 0 / Mucins
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18. Lee SE, Park NH, Park IA, Kang SB, Lee HP: Tubulo-villous adenoma of the vagina. Gynecol Oncol; 2005 Feb;96(2):556-8
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  • [Title] Tubulo-villous adenoma of the vagina.
  • BACKGROUND: Tubulo-villous adenomas are common in the colon and rectum, but extremely rare in the vagina.
  • As far as we know, only two cases of tubulo-villous adenoma have ever been reported.
  • We report the third case of enteric-type tubulo-villous adenoma of the vagina.
  • The tumor was excised and pathologically confirmed as a tubulo-villous adenoma.
  • CONCLUSION: Because some tubulo-villous adenomas in the colon and rectum can progress to the cancer, this case requires long-term follow-up to detect recurrence and malignant transformation.
  • [MeSH-major] Adenoma, Villous / pathology. Vaginal Neoplasms / pathology

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  • (PMID = 15661252.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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19. Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S: Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. BMC Cancer; 2008 Jan 29;8:33
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  • [Title] Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma.
  • METHODS: By immunohistochemistry, we assessed COX-2 expression in 24 hyperplastic polyps, 7 sessile serrated polyp/adenomas (SSA), 5 mixed polyps with SSA and adenoma, 27 traditional serrated adenomas, 515 non-serrated adenomas (tubular adenoma, tubulovillous adenoma and villous adenoma), 33 adenomas with intramucosal carcinomas, 96 adenocarcinomas with serration (corkscrew gland) and 111 adenocarcinomas without serration.
  • CONCLUSION: COX-2 overexpression is infrequent in hyperplastic polyp, SSA and mixed polyp with SSA and adenoma, compared to non-serrated and serrated adenoma.

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  • (PMID = 18230181.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA087969; United States / NCI NIH HHS / CA / P01 CA055075; United States / NCI NIH HHS / CA / K07 CA122826; United States / NCI NIH HHS / CA / P01 CA87969; United States / NCI NIH HHS / CA / P01 CA55075; United States / NCI NIH HHS / CA / P50 CA127003
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  • [Other-IDs] NLM/ PMC2257954
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20. Eckardt AJ, Swales C, Bhattacharya K, Wassef WY, Leung K, Levey JM: Does trainee participation during colonoscopy affect adenoma detection rates? Dis Colon Rectum; 2009 Jul;52(7):1337-44
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  • [Title] Does trainee participation during colonoscopy affect adenoma detection rates?
  • It remains unknown whether adenoma detection rates are adversely affected by trainee participation.
  • The primary aim of this study was to investigate whether adenoma detection rates differed between procedures with or without trainee involvement.
  • CONCLUSION: Adenoma detection rates did not differ significantly, whether there was trainee involvement or not.
  • The small difference in adenoma detection was not observed for polyp detection, which may be explained by the more frequent removal of hyperplastic polyps by trainees.
  • [MeSH-major] Adenoma / diagnosis. Clinical Competence. Colonic Neoplasms / diagnosis. Colonic Polyps / diagnosis. Colonoscopy. Diagnostic Errors

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  • (PMID = 19571713.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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21. Nivatvongs S: Management of T1 carcinoma of the lower third rectum. Acta Chir Iugosl; 2006;53(2):65-6

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  • [Title] Management of T1 carcinoma of the lower third rectum.
  • The earliest invasive carcinoma of colon and rectum is an invasion into the submucosa.
  • They present as an adenoma with invasive carcinoma, or a frank carcinoma.
  • Local excision for T1 carcinoma of the rectum can be curative if the lesion is accessible for an adequate excision and if the lesion has not spread to the lymph nodes or distant metastasis.
  • [MeSH-major] Carcinoma / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Humans. Lymphatic Metastasis. Rectum / surgery

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  • (PMID = 17139888.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia and Montenegro
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22. Huang WY, Chatterjee N, Chanock S, Dean M, Yeager M, Schoen RE, Hou LF, Berndt SI, Yadavalli S, Johnson CC, Hayes RB: Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev; 2005 Jan;14(1):152-7
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  • [Title] Microsomal epoxide hydrolase polymorphisms and risk for advanced colorectal adenoma.
  • Cigarette smoking is a risk factor for colorectal adenoma, a precursor of colorectal cancer.
  • Among participants randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we evaluated risks for advanced adenoma in relation to cigarette use and these two EPHX1 variants.
  • We compared 772 cases with advanced adenoma (adenoma >/=1 cm or containing high-grade dysplasia or villous, including tubulovillous, elements) of the distal colon (left-sided, descending colon and sigmoid or rectum) to 777 gender- and age-matched controls who were screen-negative for left-sided adenoma.
  • Compared to those with homozygous genotypes predicting low EPHX1 activity, advanced adenoma risks tended to be elevated for carriers of (113)TyrTyr [odds ratios (OR), 1.5; 95% confidence intervals (CI), 1.0-2.2] and (139)ArgArg (OR, 1.4; 95% CI, 0.8-2.5) and for subjects who carried a greater number of the alleles ((113)Tyr or (139)Arg) associated with high predicted enzymatic activity (P(trend) = 0.03).
  • In conclusion, EPHX1 variants at codon 113 and 139 associated with high predicted enzymatic activity appear to increase risk for colorectal adenoma, particularly among recent and current smokers.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Epoxide Hydrolases / genetics. Polymorphism, Genetic. Smoking / adverse effects

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  • (PMID = 15668489.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.3.2.- / Epoxide Hydrolases
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23. Schäfer H, Baldus SE, Hölscher AH: Giant adenomas of the rectum: complete resection by transanal endoscopic microsurgery (TEM). Int J Colorectal Dis; 2006 Sep;21(6):533-7
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  • [Title] Giant adenomas of the rectum: complete resection by transanal endoscopic microsurgery (TEM).
  • BACKGROUND: Large sessile adenomas of the rectum, with a diameter greater than 5 cm, have a high risk to undergo malignant transformation.
  • Transanal endoscopic microsurgery (TEM) offers an alternative operation method to low-anterior rectum resection in this potentially benign tumor situation.
  • PATIENTS: We retrospectively investigated patients with giant adenomas of the rectum (>5 cm) who were treated by TEM over the last 10 years.
  • The residual adenoma status was 18% (n=6), especially in patients with tumors sizes more than 30 cm2.
  • In case of adenoma recurrence (n=4, 12%), a conventional transanal excision (Parks) was applicable, as these tumors were mostly located within the suture-line region of the lower rectum.
  • In case of advanced tumors (1xpT2, 1xpT3), anterior rectum resection was carried out, whereas for the early tumors (2xpT1 low risk, 1x1 pTis), no further therapy was added.
  • CONCLUSION: TEM is an alternative method for the resection of large benign rectal tumors located in the mid- and upper third of the rectum.
  • [MeSH-major] Adenoma / surgery. Colonoscopy / methods. Microsurgery. Rectal Neoplasms / surgery

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  • (PMID = 16133003.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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24. Sandmeier D, Bouzourene H: [Sessile serrated polyps of the colorectum: how to distinguish a sessile serrated adenoma from a hyperplastic polyp in a daily practice?]. Ann Pathol; 2008 Apr;28(2):79-84
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  • [Title] [Sessile serrated polyps of the colorectum: how to distinguish a sessile serrated adenoma from a hyperplastic polyp in a daily practice?].
  • [Transliterated title] Polypes dentelés du côlon et du rectum: comment reconnaître un adénome dentelé sessile d'un polype hyperplasique en pratique quotidienne?
  • RESULTS: There were 81 HP (79%), seven SSA (7%) of which one showed foci of dysplasia, five traditional serrated adenomas (5%) and three mixed polyps (HP and tubulous adenoma: 3%).
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Hyperplasia / pathology. Polyps / pathology. Rectal Diseases / pathology
  • [MeSH-minor] Biopsy. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Diagnosis, Differential. Humans. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery


25. Cho NL, Redston M, Zauber AG, Carothers AM, Hornick J, Wilton A, Sontag S, Nishioka N, Giardiello FM, Saltzman JR, Gostout C, Eagle CJ, Hawk ET, Bertagnolli MM: Aberrant crypt foci in the adenoma prevention with celecoxib trial. Cancer Prev Res (Phila); 2008 Jun;1(1):21-31
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  • [Title] Aberrant crypt foci in the adenoma prevention with celecoxib trial.
  • The natural history of these lesions and their role in the adenoma-carcinoma sequence are unknown.
  • We studied ACF in a subset of patients randomized to placebo (n = 17), celecoxib (200 mg twice daily; n = 15), or celecoxib (400 mg twice daily; n = 13) in the Adenoma Prevention with Celecoxib (APC) trial.
  • Magnification chromoendoscopy was done to identify, count, and biopsy ACF within the rectum at baseline and after 8 to 12 months of treatment.
  • Only baseline SMAD4 expression in ACF correlated with posttreatment adenoma recurrence (independent of treatment arm; P = 0.01).
  • [MeSH-major] Adenoma / prevention & control. Intestinal Mucosa / pathology. Intestinal Neoplasms / prevention & control. Precancerous Conditions / pathology. Pyrazoles / therapeutic use. Sulfonamides / therapeutic use

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  • [CommentIn] Cancer Prev Res (Phila). 2008 Jun;1(1):4-8 [19138929.001]
  • (PMID = 19138933.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers; 0 / Cyclooxygenase Inhibitors; 0 / Placebos; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib
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26. Barreda Costa C, Vila Gutierrez S, Salazar Cabrera F, Barriga Calle E, Velarde Criado H, Barriga Briceño J: [Advanced adenoma in 3700 colonoscopies]. Rev Gastroenterol Peru; 2010 Apr-Jun;30(2):113-20
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  • [Title] [Advanced adenoma in 3700 colonoscopies].
  • Adenomatous polyps were found throughout the colon, with a predominance of hyperplasic polyps in the rectum.
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Colonic Neoplasms / epidemiology. Colonic Polyps / epidemiology. Colonoscopy / statistics & numerical data. Rectal Neoplasms / epidemiology

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  • (PMID = 20644602.001).
  • [ISSN] 1609-722X
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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27. Shih CM, Wu SC, Lee CC, Pan CC: Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis. J Chin Med Assoc; 2007 Jan;70(1):33-5

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  • [Title] Villous adenoma of the ureter with manifestation of mucus hydroureteronephrosis.
  • Villous adenoma is most frequently found in the colon and rectum, seldom in the urinary tract and even more rarely in the ureter or pelvis.
  • The ureteral tumor proved to be villous adenoma by pathologic examination.
  • It should be noted that ureteral villous adenoma may be related to previous enteric-type metaplastic mucosa or ureteritis glandularis, demonstrates profuse production of mucus, and may eventually undergo malignant transformation.
  • [MeSH-major] Adenoma, Villous / complications. Hydronephrosis / etiology. Ureteral Neoplasms / complications

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  • (PMID = 17276931.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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28. Yasugi A, Matsuoka H, Otani H, Maeda K, Matsumoto K, Koda M, Kawaguchi K, Harada K, Yashima K, Murawaki Y, Horie Y: [Case of villous tumor of the rectum presenting with severe diarrhea and electrolyte depletion syndrome]. Nihon Shokakibyo Gakkai Zasshi; 2009 Mar;106(3):377-82
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  • [Title] [Case of villous tumor of the rectum presenting with severe diarrhea and electrolyte depletion syndrome].
  • Abdominal CT showed tumor and fluid in the rectum.
  • Colonoscopy revealed large tumor with a villous structure in the rectum.
  • The histopathological diagnosis was adenocarcinoma with villous adenoma.
  • [MeSH-major] Adenoma, Villous / complications. Diarrhea / etiology. Rectal Neoplasms / complications. Water-Electrolyte Imbalance / etiology

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  • (PMID = 19262051.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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29. Millan MS, Gross P, Manilich E, Church JM: Adenoma detection rate: the real indicator of quality in colonoscopy. Dis Colon Rectum; 2008 Aug;51(8):1217-20
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  • [Title] Adenoma detection rate: the real indicator of quality in colonoscopy.
  • Adenoma detection rate is rarely reported, although it seems to depend on the time taken for withdrawal.
  • We have reviewed the adenoma detection rates of six colorectal surgeons to provide insight into the range of adenoma detection rates and the factors that influence them.
  • Colonoscopy completion rates, adenoma detection rates, and times of insertion and withdrawal were noted and stratified by the six staff colonoscopists.
  • Adenoma detection rates were tabulated for the four common indications for colonoscopy.
  • With the exclusion of one outlier staff, regression of withdrawal time against adenoma detection rate produced an r(2) of 0.975 (P = 0.0016).
  • CONCLUSIONS: Adenoma detection rate is independent of completion rate as a colonoscopy quality indicator.
  • There is a wide range of adenoma detection rates among experienced colorectal surgeons.
  • Colonoscopists need to be aware of their adenoma detection rate.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy / standards. Colorectal Neoplasms / diagnosis. Quality Indicators, Health Care


30. Chung YW, Han DS, Park YK, Son BK, Paik CH, Jeon YC, Sohn JH: Risk of advanced proximal adenoma and cancer according to rectosigmoid findings in the Korean population. Dig Dis Sci; 2006 Dec;51(12):2206-12
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  • [Title] Risk of advanced proximal adenoma and cancer according to rectosigmoid findings in the Korean population.
  • In the present study, we intended to investigate the prevalence of proximal adenoma and cancer according to the findings in rectosigmoid colon and to find their risk factors.
  • Neoplasms were classified as diminutive adenoma (< or =5 mm), small adenoma (6-9 mm), advanced adenoma (> or =10 mm, with villous component or high-grade dysplasia), and cancer.
  • The sites of neoplasms were defined as rectosigmoid (rectum and sigmoid colon) and proximal (from cecum to descending colon) colon.
  • The prevalence of advanced proximal adenoma was associated with severe rectosigmoid findings.
  • Among the 131 patients with proximal advanced adenoma, 66% had no neoplasm in the rectosigmoid colon.
  • Multivariate logistic regression analysis revealed that age, gender, and advanced rectosigmoid adenoma were the risk factors of advanced proximal adenoma, but nothing was associated with the risk for proximal colon cancer.
  • Advanced rectosigmoid adenoma may be the predictor of advanced proximal adenoma, especially in old males.
  • [MeSH-major] Adenoma / diagnosis. Colonic Neoplasms / diagnosis. Colonoscopy. Sigmoid Neoplasms / diagnosis. Sigmoidoscopy

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  • (PMID = 17089187.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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31. Hou L, Chatterjee N, Huang WY, Baccarelli A, Yadavalli S, Yeager M, Bresalier RS, Chanock SJ, Caporaso NE, Ji BT, Weissfeld JL, Hayes RB: CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma. Carcinogenesis; 2005 Jun;26(6):1122-8
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  • [Title] CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma.
  • Cigarette use is a risk factor for colorectal adenoma, a known precursor of colorectal cancer.
  • We investigated the association of cigarette smoking with risk for advanced colorectal adenoma in relation to the CYP1A1 Val(462) and NQO1 Ser(187) polymorphic variants.
  • Subjects were 725 non-Hispanic Caucasian cases with advanced colorectal adenoma of the distal colon (descending colon, sigmoid and rectum) and 729 gender- and ethnicity-matched controls, randomly selected from participants in the prostate, lung, colorectal and ovarian cancer screening trial.
  • Subjects carrying either CYP1A1 Val(462) or NQO1 Ser(187) alleles were weakly associated with risk of colorectal adenoma; however, subjects carrying both CYP1A1 Val(462) and NQO1 Ser(187) alleles showed increased risks (OR = 2.2, 95% CI = 1.1-4.5), particularly among recent (including current) (OR = 17.4, 95% CI = 3.8-79.8, P for interaction = 0.02) and heavy cigarette smokers (>20 cigarettes/day) (OR = 21.1, 95% CI = 3.9-114.4, P for interaction = 0.03) compared with non-smokers who did not carry either of these variants.
  • In analysis of adenoma subtypes, the combined gene variants were most strongly associated with the presence of multiple adenoma (P = 0.002).
  • In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Cytochrome P-450 CYP1A1 / genetics. NAD(P)H Dehydrogenase (Quinone) / genetics. Polymorphism, Genetic. Smoking / adverse effects

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  • (PMID = 15731166.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human
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32. Khamidullina GA, Kapuller LL, Sereda EN, Izbagambetov NA, Zharkov NV: [Small-cell rectal carcinoma coexisted with tubular-villous adenoma]. Arkh Patol; 2006 Sep-Oct;68(5):37-9
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  • [Title] [Small-cell rectal carcinoma coexisted with tubular-villous adenoma].
  • The paper describes a case of small-cell high-grade endocrine carcinoma of the rectum concurrent with tubular-villous adenoma in a 58 year-old woman.
  • All epithelial cells of adenoma have been ascertained to be "mixed" exoendocrine endocrinocytes (secrete mucus and contain neuroendocrine granules), contain progesterone receptors, and express CK 8, 18, and 19.
  • [MeSH-major] Adenoma, Villous / pathology. Carcinoma, Small Cell / pathology. Rectal Neoplasms / pathology

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  • (PMID = 17144530.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Keratin-18; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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33. Laiyemo AO, Murphy G, Sansbury LB, Wang Z, Albert PS, Marcus PM, Schoen RE, Cross AJ, Schatzkin A, Lanza E: Hyperplastic polyps and the risk of adenoma recurrence in the polyp prevention trial. Clin Gastroenterol Hepatol; 2009 Feb;7(2):192-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperplastic polyps and the risk of adenoma recurrence in the polyp prevention trial.
  • Prospective information on the risk of adenoma recurrence associated with hyperplastic polyps is limited.
  • We sought to investigate whether the coexistence of hyperplastic polyps with adenomas increases the risk of adenoma recurrence.
  • METHODS: We used unconditional logistic regression models to examine the association between baseline hyperplastic polyps and subsequent adenoma recurrence during a 3-year follow-up evaluation, among 1637 participants in the Polyp Prevention Trial.
  • When compared with subjects without any hyperplastic polyps at baseline, there was no statistically significant association between the presence of baseline hyperplastic polyps and recurrence of any adenoma (odds ratio [OR], 1.19; 95% confidence interval [CI], 0.94-1.51) or advanced adenoma (OR, 1.25; 95% CI, 0.78-2.03).
  • Also, there was no association between hyperplastic polyp location and adenoma recurrence (OR, 1.01; 95% CI, 0.69-1.48) for any proximal hyperplastic polyp (OR, 1.26; 95% CI, 0.96-1.65) and for distal hyperplastic polyps.
  • CONCLUSIONS: The coexistence of hyperplastic polyps with adenomas, irrespective of location, does not confer an increased risk of adenoma recurrence beyond that of adenomas alone within 3 years of follow-up evaluation.
  • Prospective long-term studies on adenoma recurrence risk associated with hyperplastic polyps in screening populations are needed.
  • [MeSH-major] Adenoma / epidemiology. Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / epidemiology. Colorectal Neoplasms / pathology

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  • (PMID = 18849014.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS419206; NLM/ PMC3498978
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34. Church J: Adenoma detection rate and the quality of colonoscopy: the sword has two edges. Dis Colon Rectum; 2008 May;51(5):520-3
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  • [Title] Adenoma detection rate and the quality of colonoscopy: the sword has two edges.
  • Few publications have considered the full implications of pushing the adenoma detection rate as a prime quality indicator.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy / standards. Colorectal Neoplasms / diagnosis. Quality Indicators, Health Care

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  • (PMID = 18322755.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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35. Ji JS, Choi KY, Lee WC, Lee BI, Park SH, Choi H, Kim BW, Chae HS, Park YM, Park YJ: Endoscopic and histopathologic predictors of recurrence of colorectal adenoma on lowering the miss rate. Korean J Intern Med; 2009 Sep;24(3):196-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic and histopathologic predictors of recurrence of colorectal adenoma on lowering the miss rate.
  • BACKGROUND/AIMS: Although colorectal adenoma is reported to recur frequently, this may result from missing it at baseline.
  • This study evaluated the recurrence rate prospectively and clinical predictors of recurrence in colorectal adenoma after lowering the miss rate.
  • Thirty patients had a recurrent adenoma, for a recurrence rate of 23.4%.
  • Patients with three or four adenomas at baseline colonoscopy had a two-fold greater risk than those with one adenoma (hazard ratio, 2.44; 95% CI, 1.11-5.35).
  • Patients with advanced adenoma had a two-fold greater risk than those with no advanced adenoma (hazard ratio, 2.88; 95% CI, 1.40-5.95).
  • In multivariate analysis, only the presence of three or four adenomas independently predicted the recurrence of adenoma (hazard ratio, 3.19; 95% CI, 1.04-9.79).
  • CONCLUSIONS: The recurrence rate of colorectal adenoma corrected by lowering the miss rate was lower than reported rates.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 19721855.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2732778
  • [Keywords] NOTNLM ; Colorectal adenoma / Miss rate / Recurrence rate
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36. Akaydin M, Ersoy YE, Erozgen F, Ferlengez E, Kaplan R, Celik A, Memmi N: Tubulovillous adenoma in the common bile duct causing obstructive jaundice. Acta Gastroenterol Belg; 2009 Oct-Dec;72(4):450-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubulovillous adenoma in the common bile duct causing obstructive jaundice.
  • Villous adenomas are benign epithelial lesions with a malignant potential which can occur at any site in the gastrointestinal tract, usually in the rectum and colon, less frequently in the small bowel and very rarely in the biliary tract.
  • Common bile duct (CBD) adenomas often present in a fashion similar to their malignant counterparts, and adenocarcinoma arising from a villous adenoma of the ampullary biliary epithelium is also extremely rare.
  • We present here a tubulovillous adenoma, arising in the common bile duct, as a cause of obstructive jaundice, and discuss the characteristics of these lesions.
  • [MeSH-major] Adenoma, Villous / complications. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology

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  • (PMID = 20163042.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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37. Wark PA, Wu K, van 't Veer P, Fuchs CF, Giovannucci EL: Family history of colorectal cancer: a determinant of advanced adenoma stage or adenoma multiplicity? Int J Cancer; 2009 Jul 15;125(2):413-20
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  • [Title] Family history of colorectal cancer: a determinant of advanced adenoma stage or adenoma multiplicity?
  • A family history of colorectal cancer may increase colorectal cancer risk by influencing adenoma growth or enhancing the formation of new lesions.
  • Data of men from the prospective Health Professionals Follow-Up Study who underwent an endoscopy between 1986 and 2004 were used to evaluate whether a family history of colorectal cancer is associated with adenoma multiplicity or advanced adenoma stage (> or =1 cm, histology with villous component or carcinoma in situ).
  • 21.4% of the 3,881 adenoma patients and 13.9% of the 24,959 adenoma-free men had a first-degree relative with colorectal cancer.
  • Six hundred and twenty-two men had multiple and 1,985 had single adenomas in the distal colon and rectum.
  • A family history of colorectal cancer was similarly associated with advanced and nonadvanced adenomas [multivariable odds ratio (OR) (95% confidence interval): advanced vs. nonadvanced, 0.98 (0.82-1.17), advanced vs. adenoma-free: 1.67 (1.47-1.91), nonadvanced vs. adenoma-free: 1.70 (1.49-1.94)], although potential differences according to adenoma location were seen.
  • Our findings suggest that at the population level, heritable factors may be more important in earlier stages of adenoma formation than at stages of adenoma advancement for at least distally located adenomas.

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  • [Copyright] Copyright 2009 UICC.
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  • (PMID = 19358277.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA055075; United States / NCI NIH HHS / CA / CA055075-170001; United Kingdom / Cancer Research UK / / ; United States / NCI NIH HHS / CA / CA 55075; United States / NCI NIH HHS / CA / P01 CA055075-170001
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS98393; NLM/ PMC2914547
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38. Lai HC, Chan CY, Peng CY, Chen CB, Huang WH: Pyogenic liver abscess associated with large colonic tubulovillous adenoma. World J Gastroenterol; 2006 Feb 14;12(6):990-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pyogenic liver abscess associated with large colonic tubulovillous adenoma.
  • Rarely, liver abscess has been reported as the presenting manifestation of colonic tubulovillous adenoma.
  • Colonoscopy revealed large polypoid tumors with pathological findings of tubulovillous adenoma in both cases.
  • [MeSH-major] Adenoma / pathology. Adenoma / radiography. Colonic Neoplasms / pathology. Colonic Neoplasms / radiography. Liver Abscess, Pyogenic / pathology. Liver Abscess, Pyogenic / radiography

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  • (PMID = 16521236.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4066173
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39. Gong Z, Bostick RM, Xie D, Hurley TG, Deng Z, Dixon DA, Zhang J, Hebert JR: Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma. Int J Colorectal Dis; 2009 Jun;24(6):647-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma.
  • MATERIALS AND METHODS: In a community-, colonoscopy-based case-control study with 162 incident, sporadic colorectal adenoma cases and 211 controls, we investigated associations of two promoter polymorphisms (-842 A > G in COX1 and -765 G > C in COX2) and two polymorphisms in the 3'-UTR of COX2 (8473 T > C and 9850 A > G) with risk of adenomas.
  • Multiple logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) of colorectal adenoma after adjusting for potential confounders.
  • CONCLUSION: These results suggest that the C allele of COX2 8473 T > C polymorphism may interact with NSAIDs to reduce risk for colorectal adenoma.

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  • (PMID = 19205707.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01CA-51932; United States / NCRR NIH HHS / RR / P20 RR017698; United States / NCRR NIH HHS / RR / RR017698; United States / NCI NIH HHS / CA / R01 CA134609; United States / NCI NIH HHS / CA / U01 CA114601; United States / NCI NIH HHS / CA / 1 U01 CA114601-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS1 protein, human; EC 1.14.99.1 / PTGS2 protein, human
  • [Other-IDs] NLM/ NIHMS377403; NLM/ PMC3461962
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40. Moore LE, Huang WY, Chatterjee N, Gunter M, Chanock S, Yeager M, Welch B, Pinsky P, Weissfeld J, Hayes RB: GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev; 2005 Jul;14(7):1823-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma.
  • Cigarette smoking is a risk factor for colon adenoma.
  • We examined the prevalence of GSTM1 and GSTT1 gene deletions, and two GSTP1 polymorphisms in 772 cases with advanced colorectal adenomas (>1 cm, villous elements or high-grade dysplasia) of the distal colon (descending or sigmoid colon or rectum) and 777 sigmoidoscopy negative controls enrolled in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
  • Advanced adenoma risk was increased in current/former smokers (OR, 1.4; 95% CI, 1.2-1.8).
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Glutathione Transferase / genetics. Isoenzymes / genetics. Polymorphism, Genetic

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  • (PMID = 16030123.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / GSTP1 protein, human; EC 2.5.1.18 / Glutathione S-Transferase pi; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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41. Jacobs ET, Martínez ME, Alberts DS, Jiang R, Lance P, Lowe KA, Thompson PA: Association between body size and colorectal adenoma recurrence. Clin Gastroenterol Hepatol; 2007 Aug;5(8):982-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between body size and colorectal adenoma recurrence.
  • BACKGROUND & AIMS: Obesity has been associated with increased risk for colorectal adenoma, although its role as a risk factor after polypectomy for recurrence is unclear.
  • Therefore, we sought to evaluate the effect of anthropometric measures of obesity on adenoma after polypectomy.
  • METHODS: Subjects with baseline adenomas (n = 2465) and follow-up colonoscopy data were drawn from 2 randomized trials designed to prevent adenoma recurrence.
  • RESULTS: Over a mean follow-up period of 3.1 years presence of a body mass index (BMI) > or = 30 kg/m2 was associated with a nonsignificant 17% increase in the odds for any adenoma recurrence among all subjects (odds ratio [OR], 1.17; 95% confidence interval [CI], 0.92-1.48).
  • Analyses of the effects of obesity on more clinically significant lesions demonstrated that high BMI was a slightly stronger risk factor for advanced adenoma recurrences in men (OR, 1.62; 95% CI, 1.04-2.53) when compared with non-advanced lesions (OR, 1.26; 95% CI, 0.91-1.75).
  • In addition, we observed an association for obesity and odds of adenoma recurrence among participants reporting a family history of colorectal cancer (OR, 2.25; 95% CI, 1.32-3.84) but not for those without (OR, 1.00; 95% CI, 0.77 to 1.31; P(int) = P = .008).

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  • (PMID = 17553754.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K07 CA106269; United States / NCI NIH HHS / CA / P30 CA023074; United States / NCI NIH HHS / CA / 1K07CA10629-01A1; United States / NCI NIH HHS / CA / CA95060; United States / NCI NIH HHS / CA / CA-41108; United States / NCI NIH HHS / CA / P01 CA041108; United States / NCI NIH HHS / CA / P50 CA095060; United States / NCI NIH HHS / CA / CA-23074; United States / NCI NIH HHS / CA / K07 CA106269-01A1; United States / NCI NIH HHS / CA / CA106269-01A1; United States / NCI NIH HHS / CA / CA-77145
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS29366; NLM/ PMC2729188
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42. Katsinelos P, Basdanis G, Chatzimavroudis G, Karagiannoulou G, Katsinelos T, Paroutoglou G, Papaziogas B, Paraskevas G: Pancreatitis complicating mucin-hypersecreting common bile duct adenoma. World J Gastroenterol; 2006 Aug 14;12(30):4927-9
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  • [Title] Pancreatitis complicating mucin-hypersecreting common bile duct adenoma.
  • He underwent a modified Whipple operation and histological examination of the surgical specimen showed villous adenoma with rich secretion of mucus.
  • [MeSH-major] Adenoma, Bile Duct / complications. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic / pathology. Mucins / secretion. Pancreatitis / etiology

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  • (PMID = 16937485.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucins
  • [Other-IDs] NLM/ PMC4087637
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43. Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr: Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal. World J Gastroenterol; 2009 Jul 28;15(28):3560-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal.
  • We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.
  • This is the case of an octogenarian man with a several year history of hemorrhoids and intermittent rectal bleeding, more recently complaining of continuous hematochezia.
  • Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma.
  • Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Anal Canal / pathology

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  • (PMID = 19630115.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2715986
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44. Ratiu N, Gelbmann C, Rath HR, Herfarth H, Kullmann F, Schölmerich J, Messmann H: Chromoendoscopy with indigo carmine in flexible sigmoidoscopy screening: does it improve the detection of adenomas in the distal colon and rectum? J Gastrointestin Liver Dis; 2007 Jun;16(2):153-6
Hazardous Substances Data Bank. Indigotindisulfonate sodium .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromoendoscopy with indigo carmine in flexible sigmoidoscopy screening: does it improve the detection of adenomas in the distal colon and rectum?
  • BACKGROUND AND AIMS: The aim of our study was to determine whether chromoendoscopy with indigo carmine significantly improves the detection of adenomas in the distal colon and rectum and therefore could become routine in flexible sigmoidoscopy screening.
  • CONCLUSIONS: Chromoendoscopy with indigo carmine allows the detection of significantly more adenomas <or= 5 mm in the distal colon and rectum.
  • [MeSH-major] Adenoma / diagnosis. Colorectal Neoplasms / diagnosis. Coloring Agents. Indigo Carmine. Sigmoidoscopy

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  • (PMID = 17592561.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Coloring Agents; D3741U8K7L / Indigo Carmine
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45. Keku TO, Amin A, Galanko J, Martin C, Schliebe B, Sandler RS: Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas. Cancer Epidemiol Biomarkers Prev; 2008 Feb;17(2):306-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas.
  • Low apoptosis in the normal rectal mucosa has been associated with colorectal adenomas in cross-sectional studies.
  • We evaluated whether apoptosis at baseline colonoscopy, as well as patient and adenoma characteristics, could predict future occurrence of adenomas.
  • Study subjects were participants in the Diet and Health Study III, a cross-sectional study of adenoma risk factors between August 1998 and March 2000.
  • At baseline, subjects underwent colonoscopy and provided normal rectal mucosal biopsies to evaluate apoptosis as well as information about diet and lifestyle.
  • Compared with those in the lowest tertile, subjects with high apoptosis were less likely to have an adenoma at follow-up (crude OR, 0.25; 95% CI, 0.09-0.65; adjusted OR, 0.29; 95% CI, 0.08-1.06).
  • This study suggests that lower apoptosis is associated with increased risk of future adenoma development.

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  • (PMID = 18268113.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK007386-28; United States / NCI NIH HHS / CA / R01 CA044684; United States / NCI NIH HHS / CA / R01 CA044684-17; United States / NCI NIH HHS / CA / K01 CA093654; United States / NIDDK NIH HHS / DK / P30 DK034987-24; United States / NIDDK NIH HHS / DK / P30 DK034987; United States / NCI NIH HHS / CA / K01 CA93654; United States / NIDDK NIH HHS / DK / T35DK007386; United States / NIDDK NIH HHS / DK / T35 DK007386-28; United States / NCI NIH HHS / CA / CA044684-17; United States / NIDDK NIH HHS / DK / DK034987-24; United States / NCI NIH HHS / CA / K01 CA093654-04; United States / NIDDK NIH HHS / DK / T35 DK007386; United States / NCI NIH HHS / CA / CA093654-04; United States / NIDDK NIH HHS / DK / P30 DK34987; United States / NCI NIH HHS / CA / R01 CA44684
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS90219; NLM/ PMC2636570
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46. Gualco G, Reissenweber N, Cliché I, Bacchi CE: Flat elevated lesions of the colon and rectum: a spectrum of neoplastic and nonneoplastic entities. Ann Diagn Pathol; 2006 Dec;10(6):333-8
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  • [Title] Flat elevated lesions of the colon and rectum: a spectrum of neoplastic and nonneoplastic entities.
  • The aim of this prospective study is to establish the frequency and the type (neoplastic and nonneoplastic) lesions defined endoscopically as flat elevated lesion (FEL) in the colon and rectum, as well as to compare flat adenomas (FAs) to polypoid lesions of the same size with morphometric and immunohistochemical analysis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Colonic Neoplasms / pathology. Endoscopy, Gastrointestinal / methods. Rectal Neoplasms / pathology

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  • (PMID = 17126250.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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47. Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER: Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res; 2007 Oct 15;67(20):9721-30
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.
  • The predominantly distal colon and rectal distribution of tumors seen in mice where one Apc allele was inactivated in epithelial cells from distal ileum to rectum suggests that regional differences in the intestinal tract in the frequency and nature of secondary genetic and epigenetic events associated with adenoma outgrowth have a contributing role in determining where adenomas develop.
  • The presence of large numbers of small intestine tumors seemed to inhibit colorectal tumor development in the mouse, and gender-specific effects on tumor multiplicity in the distal mouse colon and rectum mimic the situation in humans where males have a larger number of advanced adenomas and carcinomas in the distal colon and rectum than females.
  • [MeSH-major] Adenoma / genetics. Adenoma / pathology. Colonic Neoplasms / genetics. Colonic Neoplasms / pathology. Genes, APC. Homeodomain Proteins / genetics. Transcription Factors / genetics

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  • (PMID = 17942902.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA082223; United States / NCI NIH HHS / CA / CA085463; United States / NCI NIH HHS / CA / CA46592
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdx2 protein, mouse; 0 / Homeodomain Proteins; 0 / Nuclear Localization Signals; 0 / Transcription Factors; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases
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48. Oh K, Willett WC, Wu K, Fuchs CS, Giovannucci EL: Calcium and vitamin D intakes in relation to risk of distal colorectal adenoma in women. Am J Epidemiol; 2007 May 15;165(10):1178-86
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  • [Title] Calcium and vitamin D intakes in relation to risk of distal colorectal adenoma in women.
  • The authors examined intakes of calcium and vitamin D, and interaction with retinol, in relation to risk of adenoma of the distal colon or rectum among 48,115 US women who were free of colorectal cancer or polyps, completed a food frequency questionnaire in 1980, and underwent endoscopy by 2002.
  • They documented 2,747 cases of adenoma (1,064 large, 1,531 small, 2,085 distal colon, and 779 rectal).
  • Total calcium intake was weakly associated with distal colorectal adenoma risk (multivariable relative risk (RR) for extreme quintiles = 0.88, 95% confidence interval (CI): 0.74, 1.04; p(trend) = 0.06), particularly for large adenoma (RR = 0.73, 95% CI: 0.56, 0.96; p(trend) = 0.02).
  • Total vitamin D intake was weakly associated with reduced risk of distal colorectal adenoma (RR = 0.79, 95% CI: 0.63, 0.99; p(trend) = 0.07), but more strongly with distal colon adenoma risk (RR = 0.67, 95% CI: 0.52, 0.87; p(trend) = 0.004).
  • The combinations of high vitamin D and low retinol intake (RR = 0.55, 95% CI: 0.28, 1.10) further decreased risk of distal colorectal adenoma when compared with the opposite extreme.

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  • (PMID = 17379616.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK040561; None / None / / P30 DK040561-12; United States / NCI NIH HHS / CA / CA 87969; United States / NIDDK NIH HHS / DK / P30 DK040561-12; United States / NCI NIH HHS / CA / CA 55075
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary; 11103-57-4 / Vitamin A; 1406-16-2 / Vitamin D
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49. Murff HJ, Shrubsole MJ, Smalley WE, Wu H, Shyr Y, Ness RM, Zheng W: The interaction of age and hormone replacement therapy on colon adenoma risk. Cancer Detect Prev; 2007;31(2):161-5
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  • [Title] The interaction of age and hormone replacement therapy on colon adenoma risk.
  • RESULTS: There was a significant interaction between age and hormone replacement therapy use (P=0.03) with current estrogen users who were over 56 years of age having a reduced odds of colon adenoma (OR, 0.40; 95% CI, 0.16-0.98) when compared to never users.

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  • (PMID = 17433566.001).
  • [ISSN] 0361-090X
  • [Journal-full-title] Cancer detection and prevention
  • [ISO-abbreviation] Cancer Detect. Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / K07 CA114029; United States / NCI NIH HHS / CA / R01 CA097386-01; United States / NCI NIH HHS / CA / K07 CA114029-01A2; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / P50 CA095103-01; United States / NCI NIH HHS / CA / CA95103; United States / NCI NIH HHS / CA / CA097386-01; United States / NCI NIH HHS / CA / R01 CA97386
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS24075; NLM/ PMC1949417
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50. Shaukat A, Parekh M, Lipscomb J, Ladabaum U: Can calcium chemoprevention of adenoma recurrence substitute or serve as an adjunct for colonoscopic surveillance? Int J Technol Assess Health Care; 2009 Apr;25(2):222-31
Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can calcium chemoprevention of adenoma recurrence substitute or serve as an adjunct for colonoscopic surveillance?
  • METHODS: We constructed a Markov model of post-polypectomy adenoma recurrence and colorectal cancer (CRC) development, calibrated to data from prospective chemoprevention trials of fiber, calcium, antioxidants, and aspirin.
  • (iii) surveillance colonoscopy from age 50-80 every 5 years, or 3 years for large adenoma;.
  • [MeSH-major] Adenoma / prevention & control. Calcium / economics. Colonic Polyps / prevention & control. Colonoscopy. Colorectal Neoplasms / prevention & control

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  • (PMID = 19331713.001).
  • [ISSN] 1471-6348
  • [Journal-full-title] International journal of technology assessment in health care
  • [ISO-abbreviation] Int J Technol Assess Health Care
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA101849; United States / NCI NIH HHS / CA / R01 CA101849-01A1; United States / NCI NIH HHS / CA / R01 CA101849-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS209119; NLM/ PMC2972652
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51. Pufulete M, Al-Ghnaniem R, Khushal A, Appleby P, Harris N, Gout S, Emery PW, Sanders TA: Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut; 2005 May;54(5):648-53
Hazardous Substances Data Bank. FOLIC ACID .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma.
  • The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma using a randomised, double blind, placebo controlled, parallel design.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. DNA Methylation / drug effects. Dietary Supplements. Folic Acid / pharmacology
  • [MeSH-minor] Aged. DNA, Neoplasm / genetics. Double-Blind Method. Erythrocytes / metabolism. Female. Homocysteine / blood. Humans. Intestinal Mucosa / drug effects. Intestinal Mucosa / metabolism. Leukocytes / drug effects. Leukocytes / metabolism. Male. Middle Aged. Rectum / drug effects. Rectum / metabolism

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  • MedlinePlus Health Information. consumer health - Dietary Supplements.
  • MedlinePlus Health Information. consumer health - Folic Acid.
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  • [CommentIn] Gut. 2005 May;54(5):579-81 [15831897.001]
  • (PMID = 15831910.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0LVT1QZ0BA / Homocysteine; 935E97BOY8 / Folic Acid
  • [Other-IDs] NLM/ PMC1774481
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52. Qiu HZ, Lin GL, Xiao Y, Wu B: The use of posterior trans-sphincteric approach in surgery of the rectum: a Chinese 16-year experience. World J Surg; 2008 Aug;32(8):1776-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The use of posterior trans-sphincteric approach in surgery of the rectum: a Chinese 16-year experience.
  • BACKGROUND: The posterior trans-sphincteric approach to treat different lesions of the rectum has been known since the last century.
  • The purpose of this study is to reevaluate the role of this conventional approach to surgery of the rectum from the authors' 16 years experience.
  • METHODS: Data were collected retrospectively from clinical records of 102 patients with mid- to low-lying rectal neoplastic disease treated by a single surgeon using a posterior trans-sphincteric approach to the rectum at Peking Union Medical College Hospital, China, between August 1990 and August 2006.
  • Indications for surgery were rectal villous adenoma in 36, early rectal carcinoma in 43, advanced rectal carcinoma in 10, and rectal submucosal neoplastic disease in 13.
  • All 102 rectal neoplastic diseases achieved complete excision (partial rectectomy in 96, segmental rectectomy in 6), and the resection margins were all clear.
  • CONCLUSION: The posterior trans-sphincteric approach is suitable for mid- to low-lying rectal lesions amenable to treatment using local therapy.
  • [MeSH-major] Digestive System Surgical Procedures / methods. Rectal Neoplasms / surgery

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  • (PMID = 18560934.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Lièvre A, Milet J, Carayol J, Le Corre D, Milan C, Pariente A, Nalet B, Lafon J, Faivre J, Bonithon-Kopp C, Olschwang S, Bonaiti-Pellié C, Laurent-Puig P, members of the ANGH group: Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma. BMC Cancer; 2006;6:270
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic polymorphisms of MMP1, MMP3 and MMP7 gene promoter and risk of colorectal adenoma.
  • To document the role of MMP polymorphisms in the early step of colorectal carcinogenesis, we investigated their association with colorectal adenoma risk in a case-control study comprising 295 patients with large adenomas (LA), 302 patients with small adenomas (SA) and 568 polyp-free (PF) controls.
  • METHODS: Patients were genotyped using automated fragment analysis for MMP1 -1607 ins/del G and MMP3 -1612 ins/delA (MMP3.1) polymorphisms and allelic discrimination assay for MMP3 -709 A/G (MMP3.2) and MMP7 -181 A/G polymorphisms.
  • CONCLUSION: These data show a relation between MMP1 -1607 ins/del G and MMP3 -1612 ins/delA combined polymorphisms and risk of SA, suggesting their potential role in the early steps of colorectal carcinogenesis.

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  • (PMID = 17125518.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.7 / Matrix Metalloproteinase 1
  • [Other-IDs] NLM/ PMC1687194
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54. Schäfer HH, Vivaldi C, Hölscher AH: [Local excision with transanal endoscopic microsurgery (TEM) after endoscopic R1/R2-polypectomy of pT1 "low-risk" carcinomas of the rectum]. Z Gastroenterol; 2006 Aug;44(8):647-50
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Local excision with transanal endoscopic microsurgery (TEM) after endoscopic R1/R2-polypectomy of pT1 "low-risk" carcinomas of the rectum].
  • The transanal endoscopic microsurgery (TEM) is an adequate method for the local full-thickness excision of large rectum polyps and pT1 "low-risk" rectal carcinomas.
  • We studied prospectively the relevance of this surgical technique concerning complete tumour excision after R1/R2-polypectomy of malignant rectal polyps.
  • 16 patients with pT1 "low-risk" rectal carcinoma and macroscopic (R2) or microscopic (R1) incomplete endoscopic polypectomy were locally resected by TEM.
  • In the remaining four cases (25 %), one adenoma with high-grade atypia, two pT1 "low-risk" carcinomas and one tumour infiltration in the mesorectal fat were diagnosed.
  • Transanal endoscopic microsurgery is a suitable method for the treatment of pT1 "low-risk" rectal carcinomas after incomplete endoscopic polypectomy.
  • [MeSH-major] Intestinal Polyps / surgery. Microsurgery / methods. Neoplasm Recurrence, Local / prevention & control. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 16902894.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
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55. Kim BS, Joo SH, Joo KR: Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report. World J Gastroenterol; 2008 Aug 7;14(29):4705-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct: a case report.
  • Tubulovillous adenomas are common in the colon and rectum, but are rare in the common bile duct.
  • We report a case of a carcinoma in situ arising in a tubulovillous adenoma of the distal common bile duct causing obstructive jaundice.
  • The final pathology showed a tubulovillous adenoma with carcinoma in situ of the distal common bile duct.
  • At follow-up 8 mo later, endoscopy showed multiple polyps in the rectum, colon and stomach.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Common Bile Duct Neoplasms / diagnosis

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  • (PMID = 18698689.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738799
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56. Armah HB, Krasinskas AM, Parwani AV: Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case. Diagn Pathol; 2007;2:29

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty: report of a first case.
  • We present the case of a 39-year-old male with a tubular adenoma with high-grade dysplasia in the ileal segment 34 years after augmentation ileocystoplasty to enlarge a post-chemoradiation-induced shrunken bladder.
  • Histologic examination revealed a tubular adenoma with high-grade dysplasia.
  • There are only two previous reports of tubulovillous adenoma in ileal segment after ileocystoplasty, both without high-grade dysplasia.

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  • (PMID = 17697327.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1995190
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57. Pisello F, Geraci G, Arnone E, Modica G, Stassi F, Sciumè C: [Endoscopic surveillance of colon-rectum in the narrow band imaging era]. G Chir; 2009 Oct;30(10):440-4
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  • [Title] [Endoscopic surveillance of colon-rectum in the narrow band imaging era].
  • [Transliterated title] Sorveglianza endoscopica del colon-retto. Ruolo del Narrow Band Imaging (NBI).
  • BACKGROUND AND AIMS: Colonoscopic surveillance is an established method of colorectal cancer (CRC) screening that reduces death rates, but has an adenoma miss rate of 10-20%.
  • This study evaluated the role of NBI in the improving colon adenoma detection.
  • PATIENTS AND METHODS: White light colonoscope was compared with NBI for adenoma detection during colonoscopy.
  • The outcome parameter was the difference in the adenoma detection rate between the two techniques.
  • [MeSH-major] Adenoma / diagnosis. Colonoscopy / methods. Colorectal Neoplasms / diagnosis

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  • (PMID = 19954587.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] Italy
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58. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today; 2008;38(5):440-4
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  • [Title] Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
  • A 58-year-old man who had undergone total colectomy for FAP 18 years earlier was hospitalized for carcinoma arising from the residual rectum.
  • On pathologic examination, the major duodenal papilla was completely obstructed by the carcinoma, and the minor papilla was also involved by the adenoma.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications. Ampulla of Vater. Common Bile Duct Neoplasms / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / etiology


59. Koning GG, Rensma PL, van Milligen de Wit AW, van Laarhoven CJ: In-one-continuity rectal excision and anal mucosectomy of a giant villous adenoma: an alternative surgical approach. Case Rep Gastroenterol; 2008;2(2):175-80

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  • [Title] In-one-continuity rectal excision and anal mucosectomy of a giant villous adenoma: an alternative surgical approach.
  • BACKGROUND: The authors present a woman suffering from McKittrick-Wheelock syndrome (MKWS) with a giant rectal villous adenoma.
  • MKWS is a rare disorder caused by fluid and electrolyte hypersecretion from a rectal tumor.
  • At colonoscopy an 8-cm villous adenoma was seen in the rectum.
  • An in-one-continuity anal mucosectomy and complete rectal excision were performed and restored by a handmade colonic-anal anastomosis.
  • In-one-continuity transanal mucosectomy and rectum excision with a handmade colonic-anal anastomosis seemed to be a new and solid surgical therapeutic option in this case.

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  • (PMID = 21490885.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075139
  • [Keywords] NOTNLM ; Dehydration / Electrolyte disorders / McKittrick-Wheelock syndrome / Rectal surgery / Rectal villous adenoma / Renal failure
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60. Galamb O, Spisák S, Sipos F, Tóth K, Solymosi N, Wichmann B, Krenács T, Valcz G, Tulassay Z, Molnár B: Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. Br J Cancer; 2010 Feb 16;102(4):765-73
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  • [Title] Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor.
  • Discriminatory transcripts between normal and adenoma and between adenoma and CRC biopsy samples were identified using HGU133Plus2.0 microarrays.
  • RESULTS: Between normal and adenoma samples, 20 classifiers were identified, including overexpressed cadherin 3, KIAA1199, and downregulated peptide YY, glucagon, claudin 8.
  • CONCLUSION: NS398 has a reversal effect on the expression of several genes that altered in colorectal adenoma-carcinoma sequence.
  • NS398 more efficiently inverted the expression changes seen in the normal-adenoma than in the normal-carcinoma transition.
  • [MeSH-major] Adenoma / genetics. Colon / metabolism. Colorectal Neoplasms / genetics. Cyclooxygenase 2 Inhibitors / pharmacology. Gene Expression Regulation, Neoplastic / drug effects. Nitrobenzenes / pharmacology. Sulfonamides / pharmacology
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Cluster Analysis. Gene Expression Profiling. HT29 Cells. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Rectum / drug effects. Rectum / metabolism. Substrate Specificity / drug effects

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  • (PMID = 20087348.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Nitrobenzenes; 0 / Sulfonamides; 123653-11-2 / N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
  • [Other-IDs] NLM/ PMC2837560
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61. Wu K, Platz EA, Willett WC, Fuchs CS, Selhub J, Rosner BA, Hunter DJ, Giovannucci E: A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr; 2009 Dec;90(6):1623-31
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  • [Title] A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma.
  • OBJECTIVE: To assess the effect of folic acid supplementation on recurrent colorectal adenoma, we conducted a cost-efficient, double-blind, randomized trial among participants of 2 large prospective cohorts, the Health Professionals Follow-Up Study and the Nurses' Health Study.
  • The primary endpoint was any new diagnosis of adenoma during the study period (May 1996-March 2004).
  • Secondary outcomes were adenoma by site and stage and number of recurrent adenomas.
  • RESULTS: Incidence of at least one recurrent adenoma was not significantly associated with folic acid supplementation [relative risk (RR): 0.82; 95% CI: 0.59,1.13; P = 0.22].
  • Among participants with low plasma folate concentrations at baseline (<or=7.5 ng/mL), those randomly assigned to receive folic acid experienced a significant decrease in adenoma recurrence (RR: 0.61; 95% CI: 0.42, 0.90; P = 0.01), whereas for subjects with high folate concentrations at baseline (>7.5 ng/mL), supplemental folic acid had no significant effect (RR: 1.28; 95% CI: 0.82, 1.99; P = 0.27, P(interaction) = 0.01).
  • CONCLUSIONS: Our results do not support an overall protective effect of folic acid supplementation on adenoma recurrence.
  • [MeSH-major] Adenoma / prevention & control. Colorectal Neoplasms / prevention & control. Dietary Supplements. Folic Acid / administration & dosage. Neoplasm Recurrence, Local / prevention & control

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  • (PMID = 19864409.001).
  • [ISSN] 1938-3207
  • [Journal-full-title] The American journal of clinical nutrition
  • [ISO-abbreviation] Am. J. Clin. Nutr.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00512850
  • [Grant] United States / NCI NIH HHS / CA / CA 55075; United States / NCI NIH HHS / CA / CA95589; United States / NCI NIH HHS / CA / R01 CA 67883; United States / PHS HHS / / U54 100971
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 935E97BOY8 / Folic Acid
  • [Other-IDs] NLM/ PMC2777472
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62. Matthiessen P, Hansson L, Sjödahl R, Rutegård J: Anastomotic-vaginal fistula (AVF) after anterior resection of the rectum for cancer--occurrence and risk factors. Colorectal Dis; 2010 Apr;12(4):351-7
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  • [Title] Anastomotic-vaginal fistula (AVF) after anterior resection of the rectum for cancer--occurrence and risk factors.
  • OBJECTIVE: The aim of the study was to assess recto-vaginal fistula (RVF) after anterior resection of the rectum for cancer with regard to occurrence and risk factors.
  • METHOD: All female patients [median age 69.5 years, Union Internationale centre le Cancer (UICC) cancer stage IV in 10%] who developed a symptomatic RVF (n = 20) after anterior resection of the rectum for cancer from three separate cohorts of patients were identified and compared with those who developed conventional symptomatic leakage (n = 32), and those who did not leak (n = 338).
  • [MeSH-major] Adenoma / surgery. Colectomy / adverse effects. Colorectal Neoplasms / surgery. Rectovaginal Fistula / etiology

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  • (PMID = 19220383.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] England
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63. Schneider M, Scholtka B, Gottschalk U, Faiss S, Schatz D, Berghof-Jäger K, Steinberg P: Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1. Cancers (Basel); 2010;3(1):91-105
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  • [Title] Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1.
  • In the present study a recently conceived 4-gene marker panel covering the Wnt and Ras-Raf-MEK-MAPK signaling pathways was used to analyze 20 colorectal serrated lesions and 41 colorectal adenoma samples and to determine the percentage of each of the above-mentioned potentially precancerous lesions carrying at least one of the four above-mentioned genes in a mutated form.
  • Based on its excellent performance in detecting mutations in sporadic preneoplastic (in this study) and neoplastic lesions (in a previous study) of the human colon and rectum, this primer combination might also be suited to efficiently and non-invasively detect genetic alterations in stool DNA of patients with early colorectal cancer.

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  • (PMID = 24212608.001).
  • [ISSN] 2072-6694
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3756351
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64. Poole EM, Hsu L, Xiao L, Kulmacz RJ, Carlson CS, Rabinovitch PS, Makar KW, Potter JD, Ulrich CM: Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev; 2010 Feb;19(2):547-57
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  • [Title] Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
  • RESULTS: A 30% adenoma risk reduction was observed for EP2 4950G>A (intron 1; OR(GA/AA vs. GG), 0.71; 95% confidence interval, 0.52-0.99).
  • For the candidate polymorphism EP4 Val294Ile, increasing fish intake was associated with increased adenoma risk among those with variant genotypes, but not among those with the Val/Val genotype (P(interaction) = 0.02).
  • CONCLUSIONS: These data provide little support for associations between adenoma risk and genetic variability related to PGE(2), yet suggest gene-environment interactions with anti-inflammatory exposures.

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  • (PMID = 20086108.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA123577-02; United States / NCI NIH HHS / CA / R01 CA112516-05; United States / NCI NIH HHS / CA / CA089445-03; United States / NCI NIH HHS / CA / R01 CA089445-03; United States / NCI NIH HHS / CA / R01 CA089445; United States / NCI NIH HHS / CA / R01 CA112516; United States / NCI NIH HHS / CA / R01 CA114467; United States / NCI NIH HHS / CA / R01 CA114467-05; United States / NCI NIH HHS / CA / R03 CA123577; United States / NCI NIH HHS / CA / CA123577-02; United States / NCI NIH HHS / CA / R01 CA114467-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Fatty Acids, Omega-3; 0 / Fish Oils; K7Q1JQR04M / Dinoprostone
  • [Other-IDs] NLM/ NIHMS187592; NLM/ PMC2849740
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65. Liljegren A, Barker G, Elliott F, Bertario L, Bisgaard ML, Eccles D, Evans G, Macrae F, Maher E, Lindblom A, Rotstein S, Nilsson B, Mecklin JP, Möslein G, Jass J, Fodde R, Mathers J, Burn J, Bishop DT: Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. J Clin Oncol; 2008 Jul 10;26(20):3434-9
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  • [Title] Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.
  • PATIENTS AND METHODS: Colorectal Adenoma/Carcinoma Prevention Programme 2 trial is a chemoprevention trial in people classified as having HNPCC.
  • RESULTS: Seventy-four patients (10.6%) were found to have at least one adenoma at first colonoscopy, whereas 37 (5.3%) had at least one hyperplastic polyp.
  • The frequency of an adenoma at first colonoscopy increased from 5.0% (95% CI, 2.8% to 8.3%) in patients younger than 35 years old to 18.9% (95% CI, 9.4% to 32.0%) in patients age at least 55 years (P = .0001 for trend).
  • CONCLUSION: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent.

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  • (PMID = 18612159.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] ENG
  • [Grant] United Kingdom / Cancer Research UK / / A4994; United Kingdom / Medical Research Council / / G0100496; United Kingdom / Cancer Research UK / / ; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2645083
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66. Smith D, Ballal M, Hodder R, Selvachandran SN, Cade D: The adenoma carcinoma sequence: an indoctrinated model for tumorigenesis, but is it always a clinical reality? Colorectal Dis; 2006 May;8(4):296-301
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  • [Title] The adenoma carcinoma sequence: an indoctrinated model for tumorigenesis, but is it always a clinical reality?
  • OBJECTIVE: Evidence exists to support alternative pathways to the adenoma carcinoma sequence.
  • However, rectal tumours are rarely considered separately.
  • We hypothesized that tumour behaviour in the rectum may differ in terms of pathogenesis and malignant propensity.
  • Seventy-five percent of high risk diminutive adenomas were rectal in origin.
  • CONCLUSION: Our data provides indirect evidence to support the concept that a significant proportion of rectal cancers may arise via an alternative pathway to the Vogelstein model.
  • Polyp behaviour along with malignant propensity may actually be site dependent, with rectal polyps harbouring a more aggressive phenotype.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16630233.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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67. Mochizuka A, Uehara T, Nakamura T, Kobayashi Y, Ota H: Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation. Histochem Cell Biol; 2007 Nov;128(5):445-55
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  • [Title] Hyperplastic polyps and sessile serrated 'adenomas' of the colon and rectum display gastric pyloric differentiation.
  • The serrated polyp-neoplasia pathway is a novel concept that has been demonstrated to differ from the conventional adenoma-carcinoma pathway.
  • [MeSH-major] Adenoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Intestinal Polyps / pathology. Pylorus / cytology. Rectal Neoplasms / pathology

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  • (PMID = 17851679.001).
  • [ISSN] 0948-6143
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins
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68. Polydorides AD, Mukherjee B, Gruber SB, McKenna BJ, Appelman HD, Greenson JK: Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer. Am J Surg Pathol; 2008 Nov;32(11):1661-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer.
  • Adenomas from HNPCC patients were more likely to contain high numbers of adenoma-infiltrating lymphocytes (AILs) with 12 of 16 (75%) adenomas having >or=5 AILs per high-power field (HPF) as opposed to 4 of 32 (12%) adenomas in the control group (P=0.00003).
  • [MeSH-major] Adenoma / immunology. Biomarkers, Tumor / immunology. Colorectal Neoplasms / immunology. Colorectal Neoplasms, Hereditary Nonpolyposis / immunology. Lymphocytes, Tumor-Infiltrating / immunology

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  • (PMID = 18753941.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA081488
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS417252; NLM/ PMC3500084
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69. Erichsen HC, Peters U, Eck P, Welch R, Schoen RE, Yeager M, Levine M, Hayes RB, Chanock S: Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer; 2008;60(5):652-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma.
  • To investigate if common genetic variants in these two genes are associated with risk of colorectal tumor development, we conducted a case-control study of 656 Caucasian advanced distal colorectal adenoma cases and 665 Caucasian sigmoidoscopy-negative controls nested within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Organic Anion Transporters, Sodium-Dependent / genetics. Polymorphism, Genetic / genetics. Symporters / genetics

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  • (PMID = 18791929.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 DK053211-01
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organic Anion Transporters, Sodium-Dependent; 0 / SLC23A1 protein, human; 0 / SLC23A2 protein, human; 0 / Sodium-Coupled Vitamin C Transporters; 0 / Symporters
  • [Other-IDs] NLM/ NIHMS356181; NLM/ PMC3490215
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70. Thompson PA, Wertheim BC, Zell JA, Chen WP, McLaren CE, LaFleur BJ, Meyskens FL, Gerner EW: Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma. Gastroenterology; 2010 Sep;139(3):797-805, 805.e1
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  • [Title] Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma.
  • BACKGROUND & AIMS: Combination of polyamine and prostaglandin E2 (PGE2)-synthesis inhibitors reduced the risk of colorectal adenoma (CRA) by 70% in patients who received polypectomies.
  • METHODS: We analyzed rectal mucosal levels of polyamines (spermidine, spermine, and putrescine) and PGE2, treatment regimens, and risk of CRA in 267 participants of a phase IIb/III chemoprevention trial of DFMO/sulindac.
  • RESULTS: In the group that received DFMO/sulindac, spermidine-to-spermine ratio (Spd:Spm) in rectal mucosa decreased between baseline and 12- and 36-month follow-up examinations (0.30, 0.23, and 0.24, respectively; P < .001 for both comparisons to baseline).
  • CONCLUSIONS: A combination of DFMO and sulindac significantly suppressed production of rectal mucosal polyamines but not PGE2.
  • [MeSH-major] Adenoma / prevention & control. Anticarcinogenic Agents / therapeutic use. Colorectal Neoplasms / prevention & control. Dinoprostone / metabolism. Eflornithine / therapeutic use. Enzyme Inhibitors / therapeutic use. Neoplasms, Second Primary / prevention & control. Polyamines / metabolism. Rectum / drug effects. Sulindac / therapeutic use

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  • [Copyright] Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20538001.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00005882/ NCT00118365
  • [Grant] United States / NCI NIH HHS / CA / R01 CA059024; United States / NCI NIH HHS / CA / P30 CA023074; United States / NCI NIH HHS / CA / R01 CA059024-04; United States / NCI NIH HHS / CA / CA95060; United States / NCI NIH HHS / CA / R01 CA088078-01A2; United States / NCI NIH HHS / CA / P30 CA023074-34; United States / NCI NIH HHS / CA / CA23074; United States / NCI NIH HHS / CA / P30 CA062203-17; United States / NCI NIH HHS / CA / P50 CA095060; United States / NCI NIH HHS / CA / R01 CA123065; United States / NCI NIH HHS / CA / R0-1 CA88078; United States / NCI NIH HHS / CN / N0-CN-85182; United States / NCI NIH HHS / CA / P30 CA62230; United States / NCI NIH HHS / CA / P30 CA062203; United States / NCI NIH HHS / CA / R01 CA088078; United States / NCI NIH HHS / CN / N01 CN085182; United States / NCI NIH HHS / CA / P50 CA095060-10
  • [Publication-type] Clinical Trial, Phase II; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Biomarkers, Pharmacological; 0 / Enzyme Inhibitors; 0 / Polyamines; 184SNS8VUH / Sulindac; 2FZ7Y3VOQX / Spermine; K7Q1JQR04M / Dinoprostone; U87FK77H25 / Spermidine; V10TVZ52E4 / Putrescine; ZQN1G5V6SR / Eflornithine
  • [Other-IDs] NLM/ NIHMS212209; NLM/ PMC3399666
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71. Ganai S, Garb JL, Kanumuri P, Rao RS, Alexander AI, Wait RB: Mapping the rectum: spatial analysis of transanal endoscopic microsurgical outcomes using GIS technology. J Gastrointest Surg; 2006 Jan;10(1):22-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mapping the rectum: spatial analysis of transanal endoscopic microsurgical outcomes using GIS technology.
  • Transanal endoscopic microsurgery (TEM) is a technically challenging procedure hindered by rectal anatomic constraints.
  • Two- and three-dimensional maps of rectal topology were developed.
  • [MeSH-major] Geographic Information Systems. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery. Rectum / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / pathology. Adenoma / surgery. Colon, Sigmoid / pathology. Colon, Sigmoid / surgery. Female. Humans. Image Processing, Computer-Assisted / methods. Imaging, Three-Dimensional / methods. Intraoperative Complications. Male. Medical Laboratory Science. Middle Aged. Minimally Invasive Surgical Procedures. Peritoneum / pathology. Peritoneum / surgery. Postoperative Complications. Proctoscopes. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 16368487.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Chung YW, Han DS, Park KH, Eun CS, Yoo KS, Park CK: Insulin therapy and colorectal adenoma risk among patients with Type 2 diabetes mellitus: a case-control study in Korea. Dis Colon Rectum; 2008 May;51(5):593-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Insulin therapy and colorectal adenoma risk among patients with Type 2 diabetes mellitus: a case-control study in Korea.
  • PURPOSE: Patients with Type 2 diabetes mellitus may be at increased colorectal adenoma and cancer risk.
  • We investigated to determine whether insulin therapy might increase the risk of colorectal adenoma among clinically confirmed patients with Type 2 diabetes mellitus.
  • RESULTS: Adenoma cases showed significantly higher rate of chronic insulin therapy (more than 1 year) than controls (P = 0.018).
  • In multivariate regression analysis, patients who received chronic insulin therapy had three times the risk of colorectal adenoma compared with patients who received no insulin (odds ratio, 3; 95 percent confidence interval, 1.1-8.9; P = 0.04).
  • CONCLUSIONS: Chronic insulin therapy was associated with increased colorectal adenoma risk among Type 2 diabetes mellitus patients.
  • [MeSH-major] Adenoma / chemically induced. Colorectal Neoplasms / chemically induced. Diabetes Mellitus, Type 2 / drug therapy. Insulin / adverse effects


73. Sidelnikov E, Bostick RM, Flanders WD, Long Q, Cohen VL, Dash C, Seabrook ME, Fedirko V: MutL-homolog 1 expression and risk of incident, sporadic colorectal adenoma: search for prospective biomarkers of risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev; 2009 May;18(5):1599-609
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MutL-homolog 1 expression and risk of incident, sporadic colorectal adenoma: search for prospective biomarkers of risk for colorectal cancer.
  • To characterize the expression of the mismatch repair gene MutL-homolog 1 (MLH1) in normal colorectal crypts in humans, and assess parameters of its expression as a potential biomarker of risk for colorectal neoplasms, we conducted a pilot, colonoscopy-based case-control study (51 cases, 154 controls) of incident, sporadic colorectal adenoma.
  • Biopsies of normal-appearing rectal, sigmoid, and ascending colon mucosa were procured, immunohistochemically processed for MLH1 protein, and analyzed using custom quantitative image analysis procedures.
  • MLH1 expression in the ascending colon was, on average, 49% proportionally lower in cases than controls (P = 0.03), but there was little evidence for case-control differences in the rectum and sigmoid colon.
  • There was little indication of similar differences in the rectum.
  • These preliminary data suggest that lower MLH1 expression in the normal colonic mucosa, at least in the ascending colon, may be associated with increased risk of incident, sporadic colorectal adenoma, as well as with modifiable risk factors for colorectal neoplasms, thus supporting further investigation of MLH1 expression as a potential "treatable" biomarker of risk for colorectal neoplasms.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / genetics. Adenoma / genetics. Colorectal Neoplasms / genetics. Nuclear Proteins / genetics

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  • (PMID = 19423536.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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74. Daniel CR, Bostick RM, Flanders WD, Long Q, Fedirko V, Sidelnikov E, Seabrook ME: TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma. Cancer Epidemiol Biomarkers Prev; 2009 Jan;18(1):65-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TGF-alpha expression as a potential biomarker of risk within the normal-appearing colorectal mucosa of patients with and without incident sporadic adenoma.
  • METHODS: We measured expression of TGF-alpha in biopsies of normal-appearing colorectal mucosa using automated immunohistochemistry and quantitative image analysis in a subsample of 29 cases and 31 controls from a colonoscopy-based case-control study (n = 203) of biomarkers of risk for incident sporadic colorectal adenoma.
  • RESULTS: TGF-alpha expression in the rectum was 51% higher in cases compared with controls (P = 0.05) and statistically significantly associated with accepted risk factors for colorectal neoplasms (36% lower among nonsteroidal anti-inflammatory drug users, 49% lower among women using hormone replacement therapy, 79% higher among persons with a family history of colorectal cancer).
  • CONCLUSIONS: TGF-alpha expression in the normal-appearing rectal mucosa shows promise as an early, potentially modifiable biomarker of risk for colorectal cancer.

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  • (PMID = 19124482.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115230-02; United States / NCI NIH HHS / CA / R03 CA115230; United States / NCI NIH HHS / CA / R03 CA115230-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transforming Growth Factor alpha
  • [Other-IDs] NLM/ NIHMS253319; NLM/ PMC2995992
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75. Nascimbeni R, Pucciarelli S, Di Lorenzo D, Urso E, Casella C, Agostini M, Nitti D, Salerni B: Rectum-sparing surgery may be appropriate for biallelic MutYH-associated polyposis. Dis Colon Rectum; 2010 Dec;53(12):1670-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rectum-sparing surgery may be appropriate for biallelic MutYH-associated polyposis.
  • PURPOSE: The risk of cancer or severe polyposis of the rectal stump after total colectomy for MutYH-associated polyposis is scarcely defined.
  • To evaluate this risk, we describe the findings of endoscopic surveillance of the rectal stump in a series of patients with biallelic MutYH mutations and polyposis.
  • Phenotype and histology of rectal polyps were recorded at diagnosis and during follow-up.
  • Development of adenomas and carcinomas during endoscopic surveillance of the rectal stump was observed.
  • RESULTS: At diagnosis, 6 patients had attenuated polyposis (10-100 adenomas), 5 patients had classical polyposis, 8 patients had colon carcinoma, and no patient had rectal carcinoma.
  • The mean number of rectal polyps at diagnosis was 2.64 ± 2.11 (range, 0-6).
  • No patients had rectal cancer.
  • During surveillance of the rectal stump after surgery (median duration, 5 y; range, 2-23 y), no patient developed rectal cancer.
  • CONCLUSION: Total colectomy with ileorectal anastomosis may be appropriate for patients with MutYH-associated polyposis, provided that they have no rectal cancer or severe rectal polyposis at presentation and that they undergo yearly endoscopic surveillance thereafter.
  • [MeSH-minor] Adenoma / genetics. Adult. Aged. Alleles. Anastomosis, Surgical. Chromatography, High Pressure Liquid. Colectomy. Colonoscopy. Female. Humans. Italy. Male. Middle Aged. Mutation / genetics. Pedigree. Phenotype. Polymerase Chain Reaction. Population Surveillance. Registries. Retrospective Studies. Risk Factors. Statistics, Nonparametric

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  • (PMID = 21178863.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / mutY adenine glycosylase
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76. Cipolletta L, Bianco MA, Garofano ML, Cipolleta F, Piscopo R, Rotondano G: Can magnification endoscopy detect residual adenoma after piecemeal resection of large sessile colorectal lesions to guide subsequent treatment? A prospective single-center study. Dis Colon Rectum; 2009 Oct;52(10):1774-9
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  • [Title] Can magnification endoscopy detect residual adenoma after piecemeal resection of large sessile colorectal lesions to guide subsequent treatment? A prospective single-center study.
  • The sensitivity of magnification endoscopy for predicting remnant adenoma at resection margins was 98% (95% confidence interval 90-100); specificity was 90% (95% confidence interval 79-100).
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology. Endoscopy, Gastrointestinal / methods. Neoplasm, Residual / diagnosis

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  • (PMID = 19966612.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Aust DE, Baretton GB, Members of the Working Group GI-Pathology of the German Society of Pathology: Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria. Virchows Arch; 2010 Sep;457(3):291-7
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  • [Title] Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria.
  • Until recently, two major types of colorectal epithelial polyps were distinguished: the adenoma and the hyperplastic polyp.
  • [MeSH-minor] Adenoma / genetics. Adenoma / pathology. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Humans. Rectum / pathology

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  • (PMID = 20617338.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 36
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78. Gordon PV, Paxton JB, Fox NS: A methodology for distinguishing divergent cell fates within a common progenitor population: adenoma- and neuroendocrine-like cells are confounders of rat ileal epithelial cell (IEC-18) culture. BMC Cell Biol; 2005;6(1):2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A methodology for distinguishing divergent cell fates within a common progenitor population: adenoma- and neuroendocrine-like cells are confounders of rat ileal epithelial cell (IEC-18) culture.
  • The majority of IEC-18 cells in SFM alone had a loss in expression of the adenomatous polyposis coli (APC) gene at the mRNA and protein levels, consistent with adenoma-like transformation.
  • The most common fate switch that we were able to detect correlates with a down regulation of the APC gene and transformation into an adenoma-like phenotype.
  • [MeSH-minor] Adenoma / pathology. Animals. Carcinoma, Neuroendocrine / pathology. Gene Expression Profiling. Gene Expression Regulation. Genes, APC. Methods. Phenotype. Rats

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  • (PMID = 15656904.001).
  • [ISSN] 1471-2121
  • [Journal-full-title] BMC cell biology
  • [ISO-abbreviation] BMC Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC547914
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79. Park KJ, Choi HJ, Kim SH, Han SY, Hong SH, Cho JH, Kim HH: Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction. World J Gastroenterol; 2006 Jan 7;12(1):146-9
MedlinePlus Health Information. consumer health - Rectal Disorders.

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  • [Title] Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction.
  • The patient was a 56-year-old man who suffered from rectal bleeding for one day.
  • Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution.
  • An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum.
  • The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.
  • [MeSH-major] Adenoma / complications. Intussusception / surgery. Laparoscopy / methods. Rectal Diseases / surgery. Sigmoid Neoplasms / complications

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  • (PMID = 16440436.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4077479
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80. Sidelnikov E, Bostick RM, Flanders WD, Long Q, Fedirko V, Shaukat A, Daniel CR, Rutherford RE: Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients. Cancer Epidemiol Biomarkers Prev; 2010 Apr;19(4):1022-32
Hazardous Substances Data Bank. CALCIUM CARBONATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients.
  • Ninety-two men and women with at least one pathology-confirmed colorectal adenoma were treated with 2.0 g/d calcium or 800 IU/d vitamin D(3), alone or in combination, versus placebo over 6 months.
  • Colorectal crypt overall expression and distribution of MSH2 and MLH1 proteins in biopsies of normal-appearing rectal mucosa were detected by automated immunohistochemistry and quantified by image analysis.
  • These findings suggest that higher calcium and vitamin D intakes may result in increased DNA MMR system activity in the normal colorectal mucosa of sporadic adenoma patients and that the strongest effects may be vitamin D related and in the differentiation zone of the colorectal crypt.
  • [MeSH-major] Adaptor Proteins, Signal Transducing / drug effects. Adenoma / prevention & control. Antineoplastic Agents / therapeutic use. Calcium Carbonate / therapeutic use. Colorectal Neoplasms / prevention & control. MutS Homolog 2 Protein / drug effects. Nuclear Proteins / drug effects. Vitamin D / therapeutic use
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Double-Blind Method. Female. Humans. Image Interpretation, Computer-Assisted. Immunohistochemistry. Intestinal Mucosa / drug effects. Intestinal Mucosa / metabolism. Male. Middle Aged. Pilot Projects. Rectum / drug effects. Rectum / metabolism

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  • (PMID = 20332274.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA104637; United States / NCI NIH HHS / CA / R01 CA104637
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / MLH1 protein, human; 0 / Nuclear Proteins; 1406-16-2 / Vitamin D; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein; H0G9379FGK / Calcium Carbonate
  • [Other-IDs] NLM/ NIHMS422714; NLM/ PMC3513334
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81. Neĭmark AI, Snegirev IV, Neĭmark BA: [Transrectal magnetotherapy of the prostate from Intramag device in prophylaxis of postoperative complications of transurethral resection of prostatic adenoma]. Urologiia; 2006 Mar-Apr;(2):75, 77-9
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  • [Title] [Transrectal magnetotherapy of the prostate from Intramag device in prophylaxis of postoperative complications of transurethral resection of prostatic adenoma].
  • [MeSH-minor] B-Lymphocytes / immunology. Humans. Leukocyte Count. Male. Perioperative Care / methods. Prostate / microbiology. Rectum. T-Lymphocytes / immunology. Urine / microbiology

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  • (PMID = 16708596.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] Clinical Trial; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] XM0M87F357 / Ferrosoferric Oxide
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82. Hashimoto K, Higaki S, Nishiahi M, Fujiwara K, Gondo T, Sakaida I: Does chromoendoscopy improve the colonoscopic adenoma detection rate? Hepatogastroenterology; 2010 Nov-Dec;57(104):1399-404
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  • [Title] Does chromoendoscopy improve the colonoscopic adenoma detection rate?
  • The aim of our study was to determine whether chromoendoscopy with indigo carmine significantly improves the detection of adenomas in the distal colon and rectum.

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  • (PMID = 21443093.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Coloring Agents; D3741U8K7L / Indigo Carmine
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83. Zhang WW, Ren BJ, Tong HS, Zhang YL, Jiang P: [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 May;9(3):250-2
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  • [Title] [Endoscopic and histopathological features of serrated adenoma of large intestine:an analysis of 71 cases].
  • The mean sizes of the protruded and superficial SA were 10.5 mm and 16.6 mm, respectively, and both of them were frequently located in the sigmoid and rectum.
  • [MeSH-major] Adenoma / pathology. Colonoscopy. Colorectal Neoplasms / pathology

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  • (PMID = 16721690.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
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84. Mudduluru G, Medved F, Grobholz R, Jost C, Gruber A, Leupold JH, Post S, Jansen A, Colburn NH, Allgayer H: Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. Cancer; 2007 Oct 15;110(8):1697-707
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  • [Title] Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer.
  • The objectives of the current were 1) to determine Pdcd4 as a diagnostic marker in the adenoma-carcinoma sequence, 2) to support phosphorylated Akt (pAkt)-mediated Pdcd4 regulation in vivo, and 3) to obtain the first prognostic evidence of Pdcd4 in colorectal cancer.
  • Pdcd4 immunohistochemistry may be useful as a supportive diagnostic tool for the transition between normal, adenoma, and tumor tissues.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Apoptosis Regulatory Proteins / metabolism. Biomarkers, Tumor / metabolism. Colorectal Neoplasms / metabolism. Proto-Oncogene Proteins c-akt / metabolism. RNA-Binding Proteins / metabolism
  • [MeSH-minor] Colon / metabolism. Colon / pathology. Humans. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Phosphorylation. Prognosis. Prospective Studies. Rectum / metabolism. Rectum / pathology. Survival Rate

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  • (PMID = 17849461.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Biomarkers, Tumor; 0 / PDCD4 protein, human; 0 / RNA-Binding Proteins; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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85. Betambeau N, Simson JN: Staged anterior resection and TEM to preserve rectal function in synchronous malignant and benign rectal lesions. Colorectal Dis; 2007 Jun;9(5):469-71
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  • [Title] Staged anterior resection and TEM to preserve rectal function in synchronous malignant and benign rectal lesions.
  • BACKGROUND: Traditionally patients with a high rectosigmoid carcinoma and a synchronous large distal rectal adenoma would be treated by low anterior resection with associated loss of rectal function.
  • METHOD: Four patients with a carcinoma of the upper rectum or distal sigmoid colon and a synchronous distal rectal adenoma were treated by high anterior resection followed by staged Transanal Endoscopic Microsurgery (TEM) thus conserving the distal rectum.
  • Preoperative and postoperative rectal function was assessed using the St. Mark's incontinence score.
  • Rectal function was unchanged in three patients with a minor increase in the score in one.
  • CONCLUSION: Staged high anterior resection and 'rEM offers effective treatment of synchronous rectosigmoid carcinoma and distal rectal adenoma with preservation of rectal function.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Endoscopy / methods. Neoplasms, Multiple Primary / surgery. Rectal Neoplasms / surgery

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  • (PMID = 17504346.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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86. Mroczko B, Groblewska M, Okulczyk B, Kedra B, Szmitkowski M: The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients. Int J Colorectal Dis; 2010 Oct;25(10):1177-84
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  • [Title] The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients.
  • The aim of the present study was to compare the clinical significance of serum MMP-9 with TIMP-1 in the diagnosis of CRC patients and in the differentiation between colorectal adenoma (CA) and cancer.
  • [MeSH-minor] Adenoma / diagnosis. Adult. Aged. Aged, 80 and over. Antigens, Tumor-Associated, Carbohydrate / analysis. Carcinoembryonic Antigen / analysis. Case-Control Studies. Diagnosis, Differential. Female. Humans. Male. Matrix Metalloproteinase 9 / blood. Middle Aged. Prognosis. Tissue Inhibitor of Metalloproteinase-1 / blood

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  • (PMID = 20556397.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Carcinoembryonic Antigen; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Other-IDs] NLM/ PMC2928442
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87. He YG, Han Y, Hua ZL, Lin MB, Zhang HB, Lv KZ, Yin L: [Analysis of 32 patients with rectal adenoma undergoing transanal endoscopic microsurgery]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Dec;13(12):910-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of 32 patients with rectal adenoma undergoing transanal endoscopic microsurgery].
  • OBJECTIVE: To evaluate the safety and outcomes after transanal endoscopic microsurgery (TEM)for rectal adenoma.
  • METHODS: Data of 32 patients undergoing TEM for rectal adenoma between September 2006 and February 2010 in the Ruijin Hospital were reviewed.
  • RESULTS: The adenoma diameter ranged from 0.6 to 10.0(2.3±1.2) cm.
  • Complications included rectal bleeding in 1 patient, acute urinary retention in 1 patient, and pulmonary infection in 1 patient.
  • CONCLUSION: TEM is a safe and effective minimally invasive surgical technique for large rectal adenomas.
  • [MeSH-major] Adenoma / surgery. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 21186410.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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88. Grau MV, Sandler RS, McKeown-Eyssen G, Bresalier RS, Haile RW, Barry EL, Ahnen DJ, Gui J, Summers RW, Baron JA: Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study. J Natl Cancer Inst; 2009 Feb 18;101(4):267-76
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  • [Title] Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study.
  • The risk of any adenoma among frequent NSAID users was 26.8% vs 39.9% among placebo subjects who later used NSAIDs sporadically (adjusted relative risk = 0.62, 95% confidence interval [CI] = 0.39 to 0.98; P(trend) with NSAID use frequency = .03).
  • [MeSH-major] Adenoma / prevention & control. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Anticarcinogenic Agents / administration & dosage. Aspirin / administration & dosage. Colorectal Neoplasms / prevention & control

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  • (PMID = 19211442.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 098286; United States / NCI NIH HHS / CA / P30 CA023108; United States / NCI NIH HHS / CA / CA 046927; United States / NCI NIH HHS / CA / U01 CA046927; United States / NCI NIH HHS / CA / R01 CA059005
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Anticarcinogenic Agents; R16CO5Y76E / Aspirin
  • [Other-IDs] NLM/ PMC2644329
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89. de Graaf EJ, Doornebosch PG, Tetteroo GW, Geldof H, Hop WC: Transanal endoscopic microsurgery is feasible for adenomas throughout the entire rectum: a prospective study. Dis Colon Rectum; 2009 Jun;52(6):1107-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal endoscopic microsurgery is feasible for adenomas throughout the entire rectum: a prospective study.
  • INTRODUCTION: Transanal endoscopic microsurgery for rectal adenomas is safe and has low recurrence rates.
  • However, the feasibility of the procedure for all rectal adenomas is unclear.
  • METHODS: From 1996 to 2007, 353 consecutive rectal adenomas were evaluated according to a standard protocol.
  • Transanal endoscopic microsurgery was intended in all rectal adenomas.
  • All rectal adenomas were excised in one piece.
  • Rectal adenomas with incomplete margins were larger (P < 0.001) and were located more proximally (P < 0.001).
  • CONCLUSIONS: For nearly all rectal adenomas, transanal endoscopic microsurgery is safe, feasible, and has excellent results.
  • [MeSH-major] Adenoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 19581854.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Cabello Benavente R, Jara Rascón J, Monzó JI, López Díez I, Subirá Ríos D, Lledó García E, Herranz Amo F, Hernández Fernández C: [Volume determinations of the whole prostate and of the adenoma by transrectal ultrasound: correlation with surgical specimen]. Actas Urol Esp; 2006 Feb;30(2):175-80
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  • [Title] [Volume determinations of the whole prostate and of the adenoma by transrectal ultrasound: correlation with surgical specimen].
  • [Transliterated title] Correlación ecográfico-anatómica de la medición del volumen prostático total y de la zona transicional mediante ecografía transrectal.
  • [MeSH-minor] Aged. Humans. Male. Organ Size. Rectum. Retrospective Studies. Ultrasonography / methods

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  • (PMID = 16700208.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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91. Pattullo V, Bourke MJ, Tran KL, McLeod D, Williams SJ, Bailey AA, Alexander S, Mishra A, Co J: The suction pseudopolyp technique: a novel method for the removal of small flat nonpolypoid lesions of the colon and rectum. Endoscopy; 2009 Dec;41(12):1032-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • [Title] The suction pseudopolyp technique: a novel method for the removal of small flat nonpolypoid lesions of the colon and rectum.
  • [MeSH-major] Colonic Neoplasms / surgery. Colonoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Humans. Middle Aged. Suction. Young Adult

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  • [Copyright] Georg Thieme Verlag KG Stuttgart New York.
  • (PMID = 19899034.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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92. Pufulete M, Al-Ghnaniem R, Rennie JA, Appleby P, Harris N, Gout S, Emery PW, Sanders TA: Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. Br J Cancer; 2005 Mar 14;92(5):838-42
Hazardous Substances Data Bank. FOLIC ACID .

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  • [Title] Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer.

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  • (PMID = 15726099.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0LVT1QZ0BA / Homocysteine; 9007-49-2 / DNA; 935E97BOY8 / Folic Acid; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); EC 2.1.1.13 / 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; EC 4.2.1.22 / Cystathionine beta-Synthase
  • [Other-IDs] NLM/ PMC2361912
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93. Seman M, Bretagnol F, Guedj N, Maggiori L, Ferron M, Panis Y: Transanal endoscopic microsurgery (TEM) for rectal tumor: the first French single-center experience. Gastroenterol Clin Biol; 2010 Sep;34(8-9):488-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal endoscopic microsurgery (TEM) for rectal tumor: the first French single-center experience.
  • OBJECTIVE: Transanal endoscopic microsurgery (TEM) allows complete local excision of rectal tumor, especially in the middle and upper part of the rectum, and provides an alternative to conventional surgery.
  • This is a report of the first French single-center experience to assess the feasibility and postoperative results for rectal tumor excised by TEM.
  • METHODS: From October 2007 to December 2008, 27 patients underwent TEM for excision of either rectal adenoma (n=19) or carcinoma (n=8).
  • The morbidity rate was 22% (n=6), including two patients (7%) with major complications (delayed rectal bleeding) requiring readmission to hospital for both, and surgical hemostasis for one.
  • R0 resection rates for adenoma and carcinoma were 84% and 75%, respectively.
  • CONCLUSION: TEM is a safe and effective procedure with low morbidity for local rectal tumor resection.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Proctoscopy / methods. Rectal Neoplasms / surgery. Rectum / surgery

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20621428.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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94. Cirocchi R, Coccetta M, De Sol A, Morelli U, Spizzirri A, Cattorini L, Farinella E, Giustozzi G, Sciannameo F: [Minimally invasive treatment of synchronous colorectal tumours]. Chir Ital; 2008 Mar-Apr;60(2):237-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Trattamento mini-invasivo delle neoplasie sincrone del colon-retto.
  • From January 1995 to June 2007 we treated 5 patients with rectal lesions by transanal endoscopic microsurgery (TEM) together with a laparoscopic colectomy for the presence of synchronous lesions at the "Clinica Chirurgica Generale e d'Urgenza" of the University of Perugia,.
  • Surgical timing involved performing a sequential exeresis characterised by a cancer resection, followed by resection of the voluminous adenoma: TEM for rectal cancer followed by a laparoscopic right hemicolectomy with an extracorporeal anastomosis for a voluminous villous adenoma (1 patient) and laparoscopic right hemicolectomy with an extracorporeal anastomosis for cancer followed by TEM for a voluminous villous adenoma (2 patients).
  • One patient with left colon cancer associated with a voluminous villous rectal adenoma first underwent TEM for the rectal adenoma and then a left laparoscopic hemicolectomy with an extracorporeal anastomosis in order to ease the transit of the circular mechanical stapler.
  • Another patient with rectal and right colon adenomas first underwent TEM for a voluminous rectal sessile adenoma and later a right hemicolectomy.
  • The use of this minimally invasive approach allowed rectum preservation and less invasive surgery.
  • [MeSH-major] Adenoma / surgery. Colectomy / methods. Colorectal Neoplasms / surgery. Laparoscopy. Microsurgery

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  • (PMID = 18689172.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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95. Andersen V, Agerstjerne L, Jensen D, Østergaard M, Saebø M, Hamfjord J, Kure E, Vogel U: The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study. BMC Med Genet; 2009 Feb 27;10:18
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study.
  • The aim of this study was to investigate if this MDR1 polymorphism was associated with risk of colorectal adenoma (CA) and CRC in the Norwegian population.
  • [MeSH-major] Adenoma / genetics. Colorectal Neoplasms / genetics. Genetic Predisposition to Disease. P-Glycoprotein / genetics

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  • (PMID = 19250544.001).
  • [ISSN] 1471-2350
  • [Journal-full-title] BMC medical genetics
  • [ISO-abbreviation] BMC Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ABCB1 protein, human; 0 / P-Glycoprotein; 0 / P-Glycoproteins
  • [Other-IDs] NLM/ PMC2662819
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96. McCloud JM, Waymont N, Pahwa N, Varghese P, Richards C, Jameson JS, Scott AN: Factors predicting early recurrence after transanal endoscopic microsurgery excision for rectal adenoma. Colorectal Dis; 2006 Sep;8(7):581-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors predicting early recurrence after transanal endoscopic microsurgery excision for rectal adenoma.
  • INTRODUCTION: Transanal endoscopic microsurgery (TEM) is an accepted way of excising rectal adenomas with low morbidity and mortality, avoiding major resectional surgery.
  • PATIENTS AND METHODS: Patients who had undergone TEM for rectal adenomas were identified, and a retrospective review of patient, pathological and histological parameters was performed.
  • There was no significant association between recurrence at 6 months and sex, age, type or position of adenoma, height above the anal verge, or degree of dysplasia.
  • CONCLUSIONS: Histological assessment of completeness of excision of rectal adenoma and size of adenoma are important predictors of early recurrence and have potential to guide follow-up strategies after TEM.
  • [MeSH-major] Adenoma / surgery. Microsurgery. Neoplasm Recurrence, Local. Rectal Neoplasms / surgery

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  • (PMID = 16919110.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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97. Graser A, Stieber P, Nagel D, Schäfer C, Horst D, Becker CR, Nikolaou K, Lottes A, Geisbüsch S, Kramer H, Wagner AC, Diepolder H, Schirra J, Roth HJ, Seidel D, Göke B, Reiser MF, Kolligs FT: Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population. Gut; 2009 Feb;58(2):241-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population.
  • [MeSH-major] Adenoma / diagnosis. Colorectal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Colon / pathology. Colonic Polyps / diagnosis. Colonography, Computed Tomographic / methods. Colonoscopy / methods. Feces / chemistry. Female. Hemoglobins / analysis. Humans. Imaging, Three-Dimensional. Male. Middle Aged. Occult Blood. Prospective Studies. Rectum / pathology. Sample Size. Sensitivity and Specificity. Sigmoidoscopy / methods. Video Recording

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  • [CommentIn] Gut. 2010 Jan;59(1):137 [20007962.001]
  • (PMID = 18852257.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hemoglobins
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98. Radovanović-Dinić B, Nagorni A, Stamenković I, Zlatic A: [Synchronous colorectal adenomas]. Srp Arh Celok Lek; 2010 May-Jun;138(5-6):309-14
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Colorectal adenomas which are discovered simultaneously or 6 months after the diagnosis of primary adenoma or colorectal cancer (CRC) are called synchronous adenomas.
  • OBJECTIVE: The aim of the study is to show the characteristics of synchronous colorectal adenomas and to present the relation between the index rectal adenoma and the proximal synchronous tumours.
  • The biggest number of tumours was localized in the combination of rectum-sigma segments (p < 0.001).
  • There were 31 (25.6%) synchronous, that is index tumours of the rectum and 90 (74.4%) the so-called proximal synchronous tumours of the proximal part of the colon.
  • CONCLUSION: The probability of adenoma multiplication is higher in men, and it increases with age.
  • [MeSH-major] Adenoma / pathology. Colorectal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 20607974.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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99. Endreseth BH, Wibe A, Svinsås M, Mårvik R, Myrvold HE: Postoperative morbidity and recurrence after local excision of rectal adenomas and rectal cancer by transanal endoscopic microsurgery. Colorectal Dis; 2005 Mar;7(2):133-7
Genetic Alliance. consumer health - Rectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postoperative morbidity and recurrence after local excision of rectal adenomas and rectal cancer by transanal endoscopic microsurgery.
  • OBJECTIVE: Tumours in the middle and upper part of the rectum are not easy accessible to local excision.
  • Transanal endoscopic microsurgery (TEM) has been recommended for excision of sessile adenomas in the middle and upper part of the rectum, and for small cancers in patients not fit for major surgery.
  • The indications for TEM were rectal adenoma in 72 patients and rectal cancer in 7 patients.
  • Two (2.5%) patients had peroperative perforation in the intra-abdominal part of the rectum treated by laparotomy.
  • CONCLUSION: TEM is a safe technique well tolerated also by high-risk patients, and should be the preferred method in patients with benign tumours in the middle and upper part of the rectum, and in selected cases of early rectal cancer.
  • [MeSH-major] Adenoma / surgery. Microsurgery / methods. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 15720349.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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100. Parfitt JR, Shepherd NA: Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp! Histopathology; 2008 Jul;53(1):91-6
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polypoid mucosal prolapse complicating low rectal adenomas: beware the inflammatory cloacogenic polyp!
  • METHODS AND RESULTS: Four cases of low rectal adenoma with polypoid mucosal prolapse were assessed histopathologically, as well as with p53 and Ki67 antibodies.
  • [MeSH-major] Adenoma / pathology. Intestinal Mucosa / pathology. Intestinal Polyps / diagnosis. Rectal Neoplasms / pathology. Rectal Prolapse / pathology. Rectum / pathology

  • MedlinePlus Health Information. consumer health - Pelvic Support Problems.
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  • (PMID = 18484980.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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