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1. Lubiński J, Tarnowska C, Jaworowska E, Byrski T, Jakubowska A, Górski B, Bień S, Sygut J, Góźdź S, Siołek M, Sulikowski M, Lubiński J: Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort. Anticancer Res; 2008 Sep-Oct;28(5B):3011-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort.
  • BACKGROUND: The aim of the study was to examine whether pleomorphic adenoma of salivary glands can occur on the basis of constitutional BRCA-1 mutations.
  • MATERIALS AND METHODS: Two hundred and sixty-eight patients affected by mixed tumour of salivary glands were examined for occurrence of three BRCA-1 mutations dominating in Poland.
  • RESULTS: BRCA-1 mutation was detected in only one of the patients, a female affected by breast cancer and pleomorphic adenoma of parotid gland.
  • Parotid gland tumour showed clinical and histopathological features of typical pleomorphic adenoma with no morphological features of high-grade malignancy, which are characteristic of BRCA-1-dependent tumours.
  • CONCLUSION: Considering the low frequency of BRCA-1 mutation in the examined group and also the absence of features characterizing BRCA-1-dependent tumours in the only BRCA-1-positive case, pleomorphic adenoma of salivary glands should not be recognized as a BRCA-1 dependent tumour.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Genes, BRCA1. Mutation. Salivary Gland Neoplasms / genetics

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  • (PMID = 19031948.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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2. Kondo T: A case of lipomatous pleomorphic adenoma in the parotid gland: a case report. Diagn Pathol; 2009;4:16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of lipomatous pleomorphic adenoma in the parotid gland: a case report.
  • INTRODUCTION: Pleomorphic adenoma is the most common benign neoplasm of the salivary glands.
  • Extensive lipomatous involvement of the tumor is, however, a very rare finding.
  • CASE REPORT: Herein, a rare case of lipomatous pleomorphic adenoma arising in the parotid gland of a 14-year-old Japanese woman is presented.
  • CONCLUSION: This is the sixth case of lipomatous pleomorphic adenoma in the English literature.
  • Recognition of this rare subtype of pleomorphic adenoma is important for clinical diagnosis and management.

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  • [Cites] Histopathology. 1995 Sep;27(3):285-8 [8522295.001]
  • [Cites] Histopathology. 1996 Jan;28(1):87-9 [8838128.001]
  • [Cites] J Oral Pathol Med. 2004 Jan;33(1):53-5 [14675141.001]
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  • (PMID = 19497106.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Bonet-Loscertales M, Armengot-Carceller M, Gaona-Morales J, Basterra-Alegría J: Multicentric recurrent parotid pleomorphic adenoma in a child. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e743-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicentric recurrent parotid pleomorphic adenoma in a child.
  • Mixed tumours of the parotid gland are rare in childhood and recurrence of this tumour is infrequent.
  • We present a case of a multicentric doubly recurrent parotid pleomorphic adenoma, 7 and 14 years after tumour enucleation, in a 9-year-old child.
  • All the nodules resected showed the hypocellular variant of pleomorphic adenoma.
  • We consider the relationships between the choice of treatment, the histologic subtypes of pleomorphic adenomas and multifocal tumours and recurrence.
  • We conclude that tumour enucleation is a risk factor for recurrence and total parotidectomy is the treatment of choice for pleomorphic parotid adenoma also in childhood.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasm Recurrence, Local / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20173712.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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4. Wine H, Baum M: Jacques-Louis David's tumour: an opportunity to study the natural history of a pleomorphic adenoma of the parotid gland. J R Soc Med; 2008 Dec;101(12):583-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Jacques-Louis David's tumour: an opportunity to study the natural history of a pleomorphic adenoma of the parotid gland.
  • We submit that this evidence suggests that malignant transformation of a pleomorphic adenoma of the parotid gland was the proximal cause of his death.
  • [MeSH-major] Adenoma, Pleomorphic / history. Art / history. Parotid Neoplasms / history

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  • [Cites] Head Neck Surg. 1986 Jan-Feb;8(3):177-84 [3744850.001]
  • [Cites] Br J Hosp Med. 1994 May 18-31;51(10):516-21 [7921489.001]
  • [CommentIn] J R Soc Med. 2009 Apr;102(4):127 [19349500.001]
  • (PMID = 19092027.001).
  • [ISSN] 1758-1095
  • [Journal-full-title] Journal of the Royal Society of Medicine
  • [ISO-abbreviation] J R Soc Med
  • [Language] eng
  • [Publication-type] Biography; Historical Article; Journal Article
  • [Publication-country] England
  • [Personal-name-as-subject] David JL
  • [Other-IDs] NLM/ PMC2625377
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5. Moonis G, Patel P, Koshkareva Y, Newman J, Loevner LA: Imaging characteristics of recurrent pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol; 2007 Sep;28(8):1532-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging characteristics of recurrent pleomorphic adenoma of the parotid gland.
  • BACKGROUND AND PURPOSE: Pleomorphic adenoma is the most common parotid neoplasm.
  • Imaging features of recurrent parotid pleomorphic adenoma have been infrequently reported in the radiology literature.
  • In the present study, we reviewed our institutional experience with imaging of recurrent parotid pleomorphic adenomas.
  • MATERIALS AND METHODS: Retrospective imaging and chart review of 24 patients (9 men, 15 women; age, 29-63 years) with recurrent pleomorphic adenoma of the parotid were performed.
  • The presence of solitary or multiple subcutaneous T2 hyperintense lesions in the operative bed, subcutaneous fat, and/or spaces adjacent to the parotid in patients with prior parotidectomy for pleomorphic adenoma is consistent with the diagnosis of neoplastic recurrence.
  • The radiologist should maintain a high index of suspicion for recurrent pleomorphic adenoma with this characteristic imaging appearance.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / diagnosis. Parotid Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17846206.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Fodor D, Pop S, Maniu A, Cosgaria M: Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay. Med Ultrason; 2010 Sep;12(3):238-44
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  • [Title] Gray scale and Doppler ultrasonography of the benign tumors of parotid gland (pleomorphic adenoma and Warthin's tumor). Pictorial essay.
  • The purpose of this pictorial essay is to illustrate the ultrasonographic aspects of the most common benign tumors of the parotid gland: pleomorphic adenoma and Warthin's tumor.
  • [MeSH-major] Adenolymphoma / ultrasonography. Adenoma, Pleomorphic / ultrasonography. Parotid Neoplasms / ultrasonography. Ultrasonography, Doppler

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  • (PMID = 21203603.001).
  • [ISSN] 1844-4172
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Romania
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7. Arshad AR: Benign parotid lesions: is near total parotidectomy justified? Ann Acad Med Singapore; 2006 Dec;35(12):889-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benign parotid lesions: is near total parotidectomy justified?
  • INTRODUCTION: Benign tumours of the parotid gland constitute about 80% of parotid tumours.
  • The most common benign tumour of the parotid gland is pleomorphic adenoma.
  • Other conditions, like Kimura's disease, may mimic a tumour when they present as a parotid mass.
  • Various modes of treatment have been advocated for the treatment of benign parotid lesions, ranging from enucleation to near-total parotidectomy.
  • MATERIAL AND METHODS: This is an audit of an 18-year period where 173 lesions of the parotid gland (34 malignant and 139 benign lesions) were treated by the author.
  • RESULTS: There were 139 benign lesions, of which 123 were benign tumours and 16 non-tumour conditions.
  • Fourteen cases of recurrent pleomorphic adenoma of parotid that had been treated elsewhere were also operated on.
  • Near-total parotidectomy was performed on all these cases with benign lesions.
  • Near-total parotidectomy should be considered when there is a need to treat benign parotid swellings.
  • [MeSH-major] Parotid Gland / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Adenoma, Pleomorphic / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Humans. Lymphoma / surgery. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17219001.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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8. Brunese L, Ciccarelli R, Fucili S, Romeo A, Napolitano G, D'Auria V, Collina A, Califano L, Cappabianca S, Sodano A: Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography. Dentomaxillofac Radiol; 2008 Dec;37(8):464-9
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  • [Title] Pleomorphic adenoma of parotid gland: delayed enhancement on computed tomography.
  • OBJECTIVES: To assess the efficacy of multiphasic CT with 8 min delayed acquisition in the differential diagnosis between pleomorphic adenomas and other parotid neoplasias.
  • METHODS: Between January 2004 and April 2007, 62 patients with parotid enlargement were enrolled in this prospective study.
  • RESULTS: On histological examination, 36 tumours were classified as pleomorphic adenomas and 26 as non-pleomorphic adenomas.
  • On the basis of a statistical comparison, the third phase proved to be the most effective in the differential diagnosis between pleomorphic adenoma and non-pleomorphic adenomas, both for the assessment of the degree of the enhancement (in this phase, strong enhancement showed a sensitivity of 61.11%, specificity of 100%, positive predictive value (PPV) of 100% and negative predictive value (NPV) of 53.33%) and, above all, for the homogeneity of the enhancement (in this phase, indeed, uniform enhancement showed sensitivity, specificity, PPV and NPV of 100%).
  • CONCLUSIONS: Our results seem to indicate that multiphasic CT with 8 min delayed acquisition allows the differential diagnosis between pleomorphic adenomas and other parotid neoplasias.
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Parotid Neoplasms / radiography. Radiographic Image Enhancement / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19033432.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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9. Kuratomi Y, Satoh S, Hayashida S, Inokuchi A: Basal cell adenoma and lymphoepithelial cyst as recurrent tumors of pleomorphic adenoma of the parotid gland. Auris Nasus Larynx; 2006 Mar;33(1):97-100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma and lymphoepithelial cyst as recurrent tumors of pleomorphic adenoma of the parotid gland.
  • Basal cell adenoma of the parotid gland is a rare benign tumor.
  • Lymphoepithelial cyst of the parotid gland is also a rare benign tumor-like lesion.
  • We report an elderly woman, who previously underwent a removal of pleomorphic adenoma, with multiple masses in the left parotid gland.
  • Physical, MR and intra-operative examination suggested the masses as multiple recurrences of the previous pleomorphic adenoma.
  • These rare tumors should be considered in the differential diagnosis of recurrent masses after a removal of pleomorphic adenoma of the parotid gland.
  • [MeSH-major] Adenoma / pathology. Adenoma, Pleomorphic / pathology. Branchioma / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16171964.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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10. Scarpini M, Amore Bonapasta S, Ruperto M, Vestri A, Bononi M, Caporale A: Retrograde parotidectomy for pleomorphic adenoma of the parotid gland: a conservative and effective approach. J Craniofac Surg; 2009 May;20(3):967-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retrograde parotidectomy for pleomorphic adenoma of the parotid gland: a conservative and effective approach.
  • To compare the extensiveness and the effectiveness of anterograde and retrograde dissections in superficial parotidectomy for pleomorphic adenoma of the parotid gland, a review of medical records and pathology reports of consecutive patients who underwent superficial parotidectomy has been performed.
  • The sizes of the overall pathologic specimen, the tumor within the specimen, and the normal parotid tissue obtained by anterograde and retrograde approaches have been compared.
  • The size of the tumor was nonsignificantly larger for patients undergoing standard parotidectomy (P = 0.174).
  • Patients undergoing anterograde parotidectomy also had a significantly much larger volume of normal tissue removed in the course of extirpating the adenoma, as compared with patients undergoing retrograde parotidectomy (P = 0.008).
  • Despite extracapsular dissection and partial superficial parotidectomy being proposed in the last years as conservative techniques, the optimal treatment of pleomorphic adenoma remains the superficial or total parotidectomy with facial nerve primary identification and preservation.
  • Retrograde parotidectomy, reducing the extent of normal parotid gland removal, may permit a more conservative approach than standard parotidectomy, with the same complication rates and surgical effectiveness.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • [CommentIn] J Craniofac Surg. 2009 May;20(3):970 [19461346.001]
  • [ErratumIn] J Craniofac Surg. 2011 Sep;22(5):1987. Bonapasta, Stefano Amore [corrected to Amore Bonapasta, Stefano]
  • (PMID = 19461345.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. Brieger J, Duesterhoeft A, Brochhausen C, Gosepath J, Kirkpatrick CJ, Mann WJ: Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin. APMIS; 2008 Dec;116(12):1050-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin.
  • The predictive value of cadherin-11, tenascin, fascin, and mucin-1 as markers for the likelihood of recurrence in pleomorphic adenoma of the parotid gland was examined.
  • In conclusion, cadherin-11 and fascin should be further analysed for their value as markers for later recurrence in pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biomarkers, Tumor / analysis. Cadherins / analysis. Carrier Proteins / analysis. Microfilament Proteins / analysis. Neoplasm Recurrence, Local / diagnosis. Parotid Gland / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19133007.001).
  • [ISSN] 1600-0463
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Carrier Proteins; 0 / Microfilament Proteins; 0 / Mucin-1; 0 / Tenascin; 146808-54-0 / fascin; 156621-71-5 / osteoblast cadherin
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12. Gedlicka C, Item CB, Wögerbauer M, Martinek H, Heiduschka G, Erovic BM, Ch Grasl M, Thurnher D: Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations. J Surg Oncol; 2010 Feb 1;101(2):127-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations.
  • BACKGROUND AND OBJECTIVES: This retrospective study was performed to evaluate the status of p53 in pleomorphic adenomas and carcinomas ex pleomorphic adenoma in the parotid gland.
  • As loss or mutation of p53 can cause malignant transformation, the possible degeneration of pleomorphic adenomas to carcinomas ex pleomorhic adenoma was investigated by mutational analysis.
  • METHODS: Twenty-five Patients including 14 patients with pleomorphic adenomas and 11 patients with carcinoma ex pleomorphic adenoma of the parotid gland were examined for p53 status.
  • RESULTS: Fourteen pleomorphic adenomas and 11 carcinomas ex pleomorphic adenoma were screened for p53 status and potent mutations.
  • CONCLUSION: We could not detect mutations of p53 neither in benign nor malignant parotid tumors and we therefore assume that p53 plays no role in the transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Genes, p53 / genetics. Parotid Neoplasms / genetics

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  • (PMID = 19950209.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Steele NP, Wenig BM, Sessions RB: A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node. Am J Otolaryngol; 2007 Mar-Apr;28(2):130-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of pleomorphic adenoma of the parotid gland metastasizing to a mediastinal lymph node.
  • OBJECTIVE: Pleomorphic adenomas are the most common salivary gland tumors and are typically cured with complete surgical excision.
  • There are rare reports, however, in which these histologically benign tumors have inexplicably metastasized to distant sites.
  • We present a case of a patient who presented, 27 years after excision of a parotid pleomorphic adenoma, with a recurrence in the parotid bed and a mediastinal metastasis.
  • METHODS: A 43-year-old woman presented with a mass in the right parotid bed 27 years after excision of a pleomorphic adenoma of the parotid.
  • The patient's presentation, workup, and final diagnosis of benign metastasizing pleomorphic adenoma will be discussed, along with a pertinent review of the literature.
  • RESULTS: A diagnosis of recurrent pleomorphic adenoma was made from a fine needle aspiration biopsy of the right parotid mass.
  • On subsequent computed tomographic scan, chest images revealed an incidental left mediastinal mass, which also proved to be a pleomorphic adenoma on computed tomography-guided fine needle aspiration biopsy.
  • Examination of the pathology specimens confirmed a diagnosis of pleomorphic adenoma in both the parotid bed and the mediastinum.
  • No histologic characteristics of malignancy were seen in either specimen; therefore, a diagnosis of benign metastasizing mixed tumor was rendered.
  • CONCLUSION: Benign metastasizing pleomorphic adenoma is a rare and controversial but distinct clinical entity.
  • Although the definition of the term benign precludes metastatic disease, these tumors do not demonstrate any malignant features yet metastasize to distant sites.
  • It remains to be determined whether these benign metastasizing pleomorphic adenomas are really low-grade salivary malignancies.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17362821.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Behzatoglu K, Bahadir B, Huq GE, Kaplan HH: Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review. Diagn Cytopathol; 2005 Jun;32(6):367-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous infarction of a pleomorphic adenoma in parotid gland: diagnostic problems and review.
  • Although infarction of parotid gland pleomorphic adenoma (PA) following fine-needle aspiration (FNA) has been well-documented, spontaneous infarction of PA has remained as an uncommon entity in the literature.
  • To our knowledge, we report the second case of spontaneous infarction occurring in a parotid gland PA.
  • A 44-yr-old man presented with a 2-yr history of slowly enlarging right parotid mass, which had become painful 1 mo before performing FNA biopsy.
  • Although appears to be rare, spontaneous infarction of PA should be considered in the differential diagnosis, since necrosis may mimic carcinoma and cause misinterpretation of necrosis as an indication of malignancy, in an otherwise benign salivary gland neoplasm.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Adenoma, Pleomorphic / pathology. Infarction / pathology. Parotid Neoplasms / blood supply. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Humans. Male. Parotid Gland / blood supply. Parotid Gland / pathology

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  • (PMID = 15880698.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Zbären P, Tschumi I, Nuyens M, Stauffer E: Recurrent pleomorphic adenoma of the parotid gland. Am J Surg; 2005 Feb;189(2):203-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pleomorphic adenoma of the parotid gland.
  • BACKGROUND: Surgery of recurrent pleomorphic adenoma presents an increased risk of facial nerve injury and a considerable re-recurrence rate.
  • METHODS: A series of 33 patients with first recurrence of pleomorphic adenoma of the parotid gland was analyzed.
  • Histologic material of the initial and recurrent tumor were reviewed.
  • RESULTS: Multifocal recurrence and carcinoma in pleomorphic adenoma were observed in 73% and 9% of patients, respectively.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Neoplasm Recurrence, Local. Parotid Gland / pathology. Parotid Gland / surgery. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / surgery

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  • [CommentIn] Am J Surg. 2006 Aug;192(2):270 [16860648.001]
  • (PMID = 15720991.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Bhutta MF, Dunk L, Molyneux AJ, Tewary A: Parotid pleomorphic adenoma with solitary renal metastasis. Br J Oral Maxillofac Surg; 2010 Jan;48(1):61-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid pleomorphic adenoma with solitary renal metastasis.
  • We present a rare case of renal metastasis of a recurrent pleomorphic adenoma of the parotid gland in an elderly woman.
  • Metastasising pleomorphic adenoma shows malignant clinical behaviour, and although it appears histologically benign, there may be unknown molecular features that determine its unusual ability to spread.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Kidney Neoplasms / secondary. Parotid Neoplasms / pathology

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19386401.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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17. Trandafirescu MF, Cotuţiu C, Foia L: [Some particular aspects in cases of pleomorphic adenoma of the parotid gland]. Rev Med Chir Soc Med Nat Iasi; 2005 Apr-Jun;109(2):347-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Some particular aspects in cases of pleomorphic adenoma of the parotid gland].
  • [Transliterated title] Unele aspecte particulare intâlnite in cazuri de adenom pleomorf al parotidei.
  • Twenty three cases of parotid gland pleomorphic adenoma from Surgical Oro-Maxillo Facial Clinic of "Sf.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Humans. Microscopy. Parotid Gland / pathology. Retrospective Studies

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  • (PMID = 16607798.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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18. Gierek T, Majzel K, Witkowska M, Jura-Szołtys E: [Analysis of 216 cases of pleomorphic adenoma of the parotid gland]. Otolaryngol Pol; 2005;59(3):329-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Analysis of 216 cases of pleomorphic adenoma of the parotid gland].
  • Pleomorphic adenoma is the most frequent benign tumour of the salivary glands.
  • The most common localization is the parotid gland.
  • The authors present a clinical analysis of the group of 216 patients, who was treated in ENT Department and who was diagnosed as pleomorphic adenoma.
  • The frequency of incidence of mixed tumours is 50.70% of all 426 cases of parotid gland's tumours.
  • In 92, 13% cases the tumours was localized in the superficial part, only in 7.87% in deep part of the gland.
  • Sixteen patient was operated on because of the recurrence of mixed tumours.
  • [MeSH-major] Adenoma, Pleomorphic. Parotid Neoplasms

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  • (PMID = 16117385.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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19. Rodriguez KH, Vargas S, Robson C, Perez-Atayde A, Shamberger R, McGill TJ, Healy GB, Rahbar R: Pleomorphic adenoma of the parotid gland in children. Int J Pediatr Otorhinolaryngol; 2007 Nov;71(11):1717-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the parotid gland in children.
  • OBJECTIVE: To evaluate the presentation, imaging characteristics and treatment outcome of pleomorphic adenoma of the parotid in the pediatric population.
  • CONCLUSIONS: Pleomorphic adenoma is one of the most common tumors of the parotid in children.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17889377.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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20. Grabowski L, Kołodziejczyk A, Burzej-Uchto M: [A case of giant pleomorphic adenoma of the parotid gland]. Otolaryngol Pol; 2008;62(2):195-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of giant pleomorphic adenoma of the parotid gland].
  • INTRODUCTION: A case of pleomorphic adenoma of the parotid gland was reported.
  • Pleomorphic adenoma is the most common benign tumor of the major salivary glands.
  • A review of the literature confirms that this kind of tumor is less common in the minor salivary glands.
  • We described statistic population, types of the diagnostic, treatment and clinical course of pleomorphic adenoma of the parotid gland.
  • MATERIAL AND METHOD: We encountered such a tumor in a 55-year-old woman who was admitted to our Hospital.
  • RESULTS: The tumor was located under the right side of the face and was removed surgically.
  • CONCLUSION: Pleomorphic adenoma is the most common benign tumor of the major salivary glands.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Middle Aged. Paresis / etiology. Parotid Gland / pathology. Parotid Gland / surgery. Treatment Outcome

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  • (PMID = 18637446.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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21. Chiu NC, Wu HM, Chou YH, Li WY, Chiou YY, Guo WY, Chang CY: Basal cell adenoma versus pleomorphic adenoma of the parotid gland: CT findings. AJR Am J Roentgenol; 2007 Nov;189(5):W254-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma versus pleomorphic adenoma of the parotid gland: CT findings.
  • OBJECTIVE: Basal cell adenoma is a rare benign epithelial tumor of the salivary gland.
  • The objective of this study is to present the CT findings of parotid basal cell adenoma.
  • We also compare CT findings of basal cell adenoma with those of pleomorphic adenoma, the most common parotid tumor, to determine whether any features on CT can help differentiate these two entities.
  • CONCLUSION: Basal cell adenomas of the parotid gland are located chiefly in the superficial lobe.
  • The age of the patient and the attenuation on unenhanced and contrast-enhanced CT may help in differentiating basal cell adenoma from pleomorphic adenoma of the parotid gland.
  • [MeSH-major] Adenoma / radiography. Adenoma, Pleomorphic / radiography. Parotid Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 17954621.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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22. Szwedowicz P, Osuch-Wójcikiewicz E, Bruzgielewicz A, Checiński P, Nyckowska J, Grotthuss M: [Management of recurrent pleomorphic adenoma of the parotid gland: analysis of the material of Otolaryngology Department, Medical University of Warsaw between 1998 and 2008]. Otolaryngol Pol; 2010 Jun;64(7):50-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of recurrent pleomorphic adenoma of the parotid gland: analysis of the material of Otolaryngology Department, Medical University of Warsaw between 1998 and 2008].
  • OBJECTIVES: Treatment of patients with recurrent pleomorphic adenoma of the parotid gland is a challenge for a surgeon due to frequent problems with complete resection of all tumour foci while preserving continuity and function of the facial nerve.
  • The aim of this study was to evaluate the clinical presentation and treatment results of patients with recurrent pleomorphic adenoma of the parotid gland.
  • MATERIALS AND METHODS: The medical records of 35 patients (25 women and 10 men) operated on (44 operations) for recurrent pleomorphic adenoma between the years 1988 and 2008 at the Otolaryngology Department, Medical University of Warsaw, were reviewed.
  • These patients accounted for 8.9% of all patients treated for pleomorphic adenoma of the parotid gland (N=395).
  • RESULTS: All patients had palpable, nontender mass or masses in a parotid bed after 1 to 5 previous operations.
  • Malignant transformation of recurrent pleomorphic adenoma was observed in two patients (5.7%).
  • CONCLUSIONS: Recurrent pleomorphic adenoma occurs more often in younger patients and women.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Neoplasm Recurrence, Local. Parotid Neoplasms / surgery

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  • (PMID = 21171312.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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23. Khafif A: [Recurrent pleomorphic adenoma of the parotid gland]. Harefuah; 2007 Feb;146(2):111-2, 165

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent pleomorphic adenoma of the parotid gland].
  • Recurrent pleomorphic adenoma of the parotid gland is a challenging surgical experience.
  • Resection of the primary tumor with a cuff of normal tissue around it during the primary surgical resection lowers the incidence of such metastases, but even with them, metastases still occur.
  • Intraoperative monitoring of the facial nerve may be of help during these surgical interventions, but the surgeon need not rely on the monitor only, but identify the nerve based on its well known anatomy and use the monitor as another surgical tool for safe removal of the tumor.
  • Radiotherapy is reserved for patients that had multiple recurrences or had massive tumor spillage during their surgical procedure of the recurrent tumor.
  • [MeSH-major] Adenoma / pathology. Adenoma / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 17352279.001).
  • [ISSN] 0017-7768
  • [Journal-full-title] Harefuah
  • [ISO-abbreviation] Harefuah
  • [Language] heb
  • [Publication-type] Editorial; English Abstract
  • [Publication-country] Israel
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24. Ocampo-Candiani J, Vázquez-Martínez O, Regalado-Briz A, Barboza-Quintana O, Méndez-Olvera N: Cutaneous leiomyomatosis and parotid pleomorphic adenoma. J Drugs Dermatol; 2005 Sep-Oct;4(5):642-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous leiomyomatosis and parotid pleomorphic adenoma.
  • We present a case of cutaneous leiomyomas (CL) arising in a pleomorphic adenoma (PA) of the parotid gland.
  • PA and CL are benign tumors arising from the parotid gland and the erector pilli muscle, respectively.
  • They both have a benign clinical course and in most cases leiomyomas are multiple in nature.
  • PAs of the parotid are the most frequent benign tumors of the major salivary glands.
  • [MeSH-major] Adenoma, Pleomorphic / therapy. Leiomyomatosis / therapy. Parotid Neoplasms / therapy. Skin Neoplasms / therapy

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  • (PMID = 16167424.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Yang S, Wang HP, Wang XY, Guo LJ, Tang XF, Gao QH, Xuan M, Loo WT, Chow LW: Expression of CD44V6 in parotid pleomorphic adenoma and carcinoma ex pleomorphic adenoma. Expert Opin Investig Drugs; 2010 Apr;19 Suppl 1:S101-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of CD44V6 in parotid pleomorphic adenoma and carcinoma ex pleomorphic adenoma.
  • This pattern of expression might be associated with carcinogenesis of parotid pleomorphic adenoma (PPA) which is not widely studied.
  • METHODS: Expression differences of CD44v6 were detected by immunohistochemistry in samples of non-recurrent PPA, PPA before and after the recurrence, carcinoma in pleomorphic adenoma (CPA) and normal parotid.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Antigens, CD44 / genetics. Gene Expression Regulation, Neoplastic / genetics. Parotid Neoplasms / genetics

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  • (PMID = 20374021.001).
  • [ISSN] 1744-7658
  • [Journal-full-title] Expert opinion on investigational drugs
  • [ISO-abbreviation] Expert Opin Investig Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / CD44v6 antigen
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26. Zhou L, Li C, Zhang XT: [Sixty-two cases report of surgical treatment of parotid pleomorphic adenoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Dec;40(12):922-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sixty-two cases report of surgical treatment of parotid pleomorphic adenoma].
  • OBJECTIVE: To define the most appropriate surgical modality for parotid pleomorphic adenoma (PPA).
  • The course of disease before treatment, tumor size, surgical modality, post-operative histopathological findings, recurrence and the complications were analyzed.
  • Pathological findings showed that in 6 cases (10%) the capsule of PPA was incomplete in focal areas and leaded to instances of positive margins, and in 28 cases (45%) the proliferation and mitosis were found in tumor cells with capsule invasion.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Parotid Neoplasms / surgery

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  • (PMID = 16874962.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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27. Honda T, Yamamoto Y, Isago T, Nakazawa H, Nozaki M, Hirayama T: Giant pleomorphic adenoma of the parotid gland with malignant transformation. Ann Plast Surg; 2005 Nov;55(5):524-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant pleomorphic adenoma of the parotid gland with malignant transformation.
  • A 72-year-old female is described who was admitted to the hospital with a giant mixed tumor of the left parotid gland that had grown to a weight of 6051 g within 20 years and ultimately underwent resection of the mass.
  • Histopathological examination revealed adenocarcinoma cells with hyperchromatic nuclei and mitotic figures proliferated in pleomorphic adenoma.
  • Many authors have reported giant tumors weighing more than a few kilograms of the parotid glands, and most were benign.
  • The present tumor was the sixth largest among all the parotid tumors, including both benign and malignant, which were reported.
  • The tumor was successfully resected with no marked facial nerve paralysis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Cell Transformation, Neoplastic / pathology. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 16258307.001).
  • [ISSN] 0148-7043
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Emodi O, El-Naaj IA, Gordin A, Akrish S, Peled M: Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma). J Oral Maxillofac Surg; 2010 Sep;68(9):2092-8
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  • [Title] Superficial parotidectomy versus retrograde partial superficial parotidectomy in treating benign salivary gland tumor (pleomorphic adenoma).
  • PURPOSE: Of all benign salivary gland tumors of the parotid gland, pleomorphic adenoma (mixed tumor) is the most common.
  • It accounts for 60% to 70% of all benign tumors of the parotid gland.
  • PATIENTS AND METHODS: We reviewed 48 patients who underwent excision of pleomorphic adenoma of the parotid gland between 1996 and 2005 at Rambam Medical Center: 18 were treated surgically with the classical superficial parotidectomy (SP) technique, using an anterograde approach, and 30 were treated with retrograde partial superficial parotidectomy (PSP).
  • We compared the 2 surgical techniques in terms of surgical time, histopathologic size of the lesion, amount of excised healthy parotid tissue, histologic margin, and the preservation of the capsule/pseudocapsule.
  • Much more healthy parotid tissue was taken out with the classical procedure (mean, 51.4 +/- 13.6 mm; median, 50 mm) than with the retrograde PSP technique (mean, 39.2 +/- 11.8; median, 35 mm) (P = .01).
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Oral Surgical Procedures / methods. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • [Copyright] Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20728030.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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29. Wittekindt C, Streubel K, Arnold G, Stennert E, Guntinas-Lichius O: Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head Neck; 2007 Sep;29(9):822-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients.
  • BACKGROUND: Surgery for recurrent parotid pleomorphic adenoma is a challenging problem.
  • METHODS: One hundred eight patients who underwent 134 reoperations for recurrent parotid pleomorphic adenoma (follow-up, 22 years) were evaluated for histopathologic features and risk factors for recurrence.
  • RESULTS: The number of reoperations for tumor recurrence ranged from 1 to 10.
  • The mean number of recurrent tumor nodules was 26.
  • CONCLUSIONS: Surgery for recurrent parotid pleomorphic adenoma has a high rate of facial nerve morbidity.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Neoplasm Recurrence, Local / surgery. Parotid Neoplasms / surgery

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc. Head Neck 2007.
  • (PMID = 17563905.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Nitassi S, Oujilal M, Boulaich M, Essakalli L, Kzadri M: [Giant pleomorphic adenoma of the parotid gland]. Rev Stomatol Chir Maxillofac; 2009 Dec;110(6):350-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant pleomorphic adenoma of the parotid gland].
  • [Transliterated title] Adénome pléomorphe géant de la parotide.
  • INTRODUCTION: Slow evolution pleomorphic parotid adenoma may be diagnosed late.
  • We present a case of a giant pleomorphic adenoma involving the parotid glands and try to explain the reasons for the diagnostic delay and describe therapeutic specificities.
  • CASE REPORT: A 54 year-old male patient consulted for swelling of the parotid region slowly evolving over the last 10 years.
  • The CT scan revealed a heterogeneous tumor with hyperdense and hypodense areas without any associate lesions.
  • A total conservative parotidectomy was performed; the anatomopathological examination confirmed the diagnosis of a pleomorphic adenoma, weighing 1.2kg for a diameter of 19cm, without malignant degeneration.
  • DISCUSSION: The recommended treatment for giant parotid adenoma is total conservative parotidectomy.
  • Besides its functional and esthetic impact, the giant parotid adenoma is at high risk of malignant degeneration.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 19833364.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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31. Silvoniemi A, Pulkkinen J, Grénman R: Parotidectomy in the treatment of pleomorphic adenoma -- analysis of long-term results. Acta Otolaryngol; 2010 Nov;130(11):1300-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotidectomy in the treatment of pleomorphic adenoma -- analysis of long-term results.
  • CONCLUSION: Parotidectomy is an efficient surgical treatment modality for pleomorphic adenoma of the parotid gland, although some morbidity may occur.
  • In this study, the median time interval between primary surgery and the presentation of the recurrent tumor was observed to be 14.4 years.
  • OBJECTIVE: Analysis of the long-term results of patients undergoing lateral or total parotidectomy as first-line treatment of parotid pleomorphic adenoma at our institution between the years 1979 and 1996.
  • A recurrent tumor occurred in nine cases (3.9%).
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Neoplasm Recurrence, Local / epidemiology. Parotid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Causality. Child. Comorbidity. Digestive System Surgical Procedures / adverse effects. Digestive System Surgical Procedures / statistics & numerical data. Facial Paralysis / epidemiology. Facial Paralysis / etiology. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Parotid Gland / surgery. Radiotherapy, Adjuvant. Retrospective Studies. Sweating, Gustatory / epidemiology. Treatment Outcome. Young Adult

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  • (PMID = 20528201.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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32. Chen AM, Garcia J, Bucci MK, Quivey JM, Eisele DW: Recurrent pleomorphic adenoma of the parotid gland: long-term outcome of patients treated with radiation therapy. Int J Radiat Oncol Biol Phys; 2006 Nov 15;66(4):1031-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pleomorphic adenoma of the parotid gland: long-term outcome of patients treated with radiation therapy.
  • PURPOSE: To evaluate the role of radiation therapy in the management of recurrent pleomorphic adenoma of the parotid gland.
  • METHODS AND MATERIALS: Between 1960 and 2004, 34 patients were treated with postoperative radiation therapy for recurrent pleomorphic adenoma of the parotid gland to a median dose of 5000 cGy (range, 4,500-6,000 cGy).
  • CONCLUSION: The use of postoperative radiation therapy leads to excellent long-term local control for the treatment of recurrent pleomorphic adenoma with acceptable late toxicity.
  • [MeSH-major] Adenoma / radiotherapy. Adenoma / surgery. Neoplasm Recurrence, Local / radiotherapy. Parotid Neoplasms / radiotherapy. Parotid Neoplasms / surgery

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  • (PMID = 17145531.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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33. Ohba S, Fujimori M, Ito S, Matsumoto F, Hata M, Takayanagi H, Wada R, Ikeda K: A case report of metastasizing myoepithelial carcinoma of the parotid gland arising in a recurrent pleomorphic adenoma. Auris Nasus Larynx; 2009 Feb;36(1):123-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case report of metastasizing myoepithelial carcinoma of the parotid gland arising in a recurrent pleomorphic adenoma.
  • Myoepithelial carcinoma, arising in a recurrent or in a pre-existing pleomorphic adenoma of the parotid gland is an extremely rare cancer.
  • We herein report the case of myoepithelial carcinoma occurring in a recurrent pleomorphic adenoma, which showed a high metastatic potential.
  • A 53-year-old male, who had undergone a superficial parotidectomy of the pleomorphic adenoma 2 years previously, presented with recurrent parotid swelling and with multiple coin lesions in the lung.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lung Neoplasms / secondary. Myoepithelioma / pathology. Neoplasms, Second Primary / pathology. Parotid Neoplasms / pathology. Solitary Pulmonary Nodule / secondary
  • [MeSH-minor] Humans. Male. Middle Aged. Parotid Gland / surgery

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  • (PMID = 18650039.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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34. Johnson JT, Ferlito A, Fagan JJ, Bradley PJ, Rinaldo A: Role of limited parotidectomy in management of pleomorphic adenoma. J Laryngol Otol; 2007 Dec;121(12):1126-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of limited parotidectomy in management of pleomorphic adenoma.
  • There is continued controversy over the extent of parotidectomy required for removal of a benign pleomorphic adenoma from the parotid gland.
  • As a result of experience gained in the first half of the twentieth century, it was recommended that superficial parotidectomy with facial nerve dissection should be the minimal biopsy for pleomorphic adenoma.
  • Since that time, however, research has indicated that partial parotidectomy or extracapsular dissection of benign pleomorphic adenoma can be accomplished with preservation of the facial nerve without an increase in tumour recurrence.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Parotid Neoplasms / surgery

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  • (PMID = 17666140.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 21
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35. van der Schroeff MP, de Ru JA, Slootweg PJ: Case-report: metastasizing pleomorphic adenoma of the parotid gland. B-ENT; 2007;3(1):21-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case-report: metastasizing pleomorphic adenoma of the parotid gland.
  • CASE-REPORT: Metastasizing pleomorphic adenoma of the parotid gland.
  • We present a case of metastasizing pleomorphic adenoma (MPA).
  • The patient died in 2002 at the age of 64 years, following on an initial diagnosis of a pleomorphic adenoma of the right parotid gland at the age of nineteen, multiple local recurrences and finally rib metastases.
  • Histological examination of the excised tissue from the parotid gland and the metastases showed it to be a pleomorphic adenoma without any signs of malignancy, although the metastatic deposits consisted mostly of a myoepithelial component.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Bone Neoplasms / secondary. Parotid Neoplasms / diagnosis. Ribs. Tonsillar Neoplasms / secondary
  • [MeSH-minor] Adult. Combined Modality Therapy. Diphosphonates. Disease Progression. Fatal Outcome. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Organotechnetium Compounds. Parotid Gland / pathology. Parotid Gland / surgery. Radiotherapy, Adjuvant. Reoperation. Skull Neoplasms / diagnosis. Skull Neoplasms / radiotherapy. Skull Neoplasms / secondary. Skull Neoplasms / surgery

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  • (PMID = 17451122.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Organotechnetium Compounds; 0 / technetium Tc 99m hydroxydiphosphonate
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36. Leonetti JP, Marzo SJ, Petruzzelli GJ, Herr B: Recurrent pleomorphic adenoma of the parotid gland. Otolaryngol Head Neck Surg; 2005 Sep;133(3):319-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent pleomorphic adenoma of the parotid gland.
  • OBJECTIVES: To assess the long-term results in the management of 42 patients with recurrent pleomorphic adenoma of the parotid gland.
  • STUDY DESIGN: A retrospective analysis of 42 patients who underwent parotidectomy for recurrent pleomorphic adenoma was performed to study presenting clinicoradiographic features, surgical technique, facial nerve management, and the long-term risk of recurrence.
  • Seven patients developed local parotid bed or cutaneous recurrent disease, 2 patients died of unrelated causes, and 2 patients were lost to follow-up.
  • Total parotidectomy or subtotal petrosectomy with facial nerve resection in selected cases may reduce the risk of multiple episodes of pleomorphic adenoma recurrence.
  • Two of 42 patients were found to have carcinoma ex-pleomorphic adenoma, both of these patients underwent prior radiotherapy, and both died of metastatic disease.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16143173.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Behbehani R, Hussain AE, Hussain AN: Parotid tumor presenting with hemifacial spasm. Ophthal Plast Reconstr Surg; 2009 Mar-Apr;25(2):141-2
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  • [Title] Parotid tumor presenting with hemifacial spasm.
  • A 47-year-old man presented with right parotid swelling and a history of frequent attacks of hemifacial spasm.
  • MRI of the brain and neck showed a mass in the right parotid gland.
  • Fine needle aspiration biopsy of the mass revealed a pleomorphic adenoma of the parotid gland, which was confirmed after total right parotidectomy.
  • Clinicians need to be aware that patients with occult parotid tumors can present like patients with classic hemifacial spasm.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Hemifacial Spasm / etiology. Parotid Neoplasms / complications

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  • (PMID = 19300162.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neuromuscular Agents; EC 3.4.24.69 / Botulinum Toxins, Type A
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38. Zhang Y, Gomez-Fernandez CR, Jorda M, Ganjei-Azar P: Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature. Diagn Cytopathol; 2009 Nov;37(11):828-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: a case report and review of literature.
  • Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens.
  • Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung.
  • Here we present the cytologic findings of such a metastatic tumor found in the lung FNA and pleural fluid specimens from a 64-year-old woman, with a history of local recurrent salivary gland pleomorphic adenomas, who presented with multiple bilateral pulmonary nodules and pleural effusion.
  • The diagnosis of benign metastasizing pleomorphic adenoma was made based on clinical information and cytomorphology, and confirmed by immunocytochemistry.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Biopsy, Fine-Needle. Lung Neoplasms / secondary. Parotid Neoplasms / pathology. Pleural Effusion, Malignant / pathology

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  • (PMID = 19582818.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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39. Takahama A Jr, da Cruz Perez DE, Magrin J, de Almeida OP, Kowalski LP: Giant pleomorphic adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal; 2008 Jan;13(1):E58-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant pleomorphic adenoma of the parotid gland.
  • Pleomorphic adenoma is the most common type of all benign and malignant salivary gland tumors, involving more frequently the parotid gland.
  • It is a benign tumor with a slow and continuous growth that without treatment can reach an enormous size.
  • We present a case of a giant pleomorphic adenoma in a 78-year-old man with a history of more than 30 years of a growing lesion in the parotid gland.
  • The tumor was completely resected by total parotidectomy and preservation of the facial nerve.
  • Macroscopically, the tumor measured 28 cm and weighed 4.0 Kg.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18167483.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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40. Ilhan HD, Oner FH, Sarioglu S, Lebe B, Saatci AO: Bilateral choroidal metastasis from carcinoma ex pleomorphic adenoma of the parotid gland. Clin Exp Ophthalmol; 2005 Feb;33(1):70-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral choroidal metastasis from carcinoma ex pleomorphic adenoma of the parotid gland.
  • The histological, clinical and angiographic findings are reported of a 34-year-old man with bilateral visual loss who had left parotidectomy with subsequent radiotherapy due to carcinoma ex pleomorphic adenoma of the parotid gland 1 year before.
  • Although parotid gland carcinoma usually spreads via lymphatics, choroidal involvement may rarely occur due to haematogenous dissemination.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma, Pleomorphic / pathology. Choroid Neoplasms / secondary. Parotid Neoplasms / pathology

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  • (PMID = 15670083.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Coloring Agents; IX6J1063HV / Indocyanine Green
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41. Witt RL: Minimally invasive surgery for parotid pleomorphic adenoma. Ear Nose Throat J; 2005 May;84(5):308, 310-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive surgery for parotid pleomorphic adenoma.
  • Compared with total parotidectomy and complete superficial parotidectomy for the removal of a parotid pleomorphic adenoma, partial superficial parotidectomy with dissection and preservation of the facial nerve--defined as the excision of a tumor with a 2-cm margin of normal parotid parenchyma except at the point where the tumor abuts the facial nerve--is associated with a lower incidence of transient facial nerve dysfunction, facial contour disfigurement, and subsequent Frey's syndrome.
  • The author hypothesized that the use of this procedure to remove a benign pleomorphic adenoma might result in even less morbidity (transient or permanent facial nerve dysfunction, facial contour disfigurement, Frey's syndrome, and hypoesthesia) without increasing the risk of recurrence if only a 1-cm margin of normal parotid parenchyma was removed and if the posterior branches of the great auricular nerve were preserved To test this hypothesis, the author conducted a retrospective study of 30 patients--15 who had undergone the standard partial procedure (2-cm margin with great auricular nerve sacrifice) and 15 who had undergone the modified version (1-cm margin with great auricular nerve preservation).
  • Although a 1-cm area of normal parotid parenchyma around a benign pleomorphic adenoma was a safe margin, it was no better than a 2-cm margin in terms ofmorbidity and recurrence.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Parotid Neoplasms / surgery

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  • (PMID = 15971755.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Silva SJ, Costa Junior GT, Brant Filho AC, Faria PR, Loyola AM: Metachronous bilateral pleomorphic adenoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Mar;101(3):333-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous bilateral pleomorphic adenoma of the parotid gland.
  • Bilateral salivary gland tumors are very rare, accounting for 3% of all parotid gland tumors.
  • Although the most common tumor with bilateral development is the Warthin tumor, pleomorphic adenomas (PA) have been diagnosed simultaneously as well, but in a smaller incidence.
  • We present a case of bilateral metachronous PA affecting the parotid gland in a 63-year-old woman.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Facial Nerve / surgery. Female. Humans. Middle Aged. Parotid Gland / surgery

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  • (PMID = 16504867.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 51
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43. Lee DK, Chung KW, Baek CH, Jeong HS, Ko YH, Son YI: Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging. J Comput Assist Tomogr; 2005 Nov-Dec;29(6):884-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland: characteristics of 2-phase helical computed tomography and magnetic resonance imaging.
  • OBJECTIVE: The goal of this study was to report the radiologic characteristics of basal cell adenoma of the parotid gland, which is a relatively rare neoplasm.
  • METHODS: A radiology and otolaryngology specialist reviewed the 2-phase helical computed tomography (CT) (n = 6) and/or magnetic resonance (MR) imaging (n = 2) scans of 7 patients with basal cell adenoma.
  • The authors evaluated the imaging characteristics, including tumor size, location, contour and margin, internal density or signal intensity, contrast enhancement pattern, and presence of calcification.
  • Calcification was found in a tumor.
  • CONCLUSIONS: Basal cell adenomas of the parotid gland present as small well-marginated tumors and appear as masses with central large cysts or solid masses with microcysts on CT and MR imaging scans.
  • Basal cell adenomas of the parotid gland had at least 2 different enhancement patterns on the 2-phase helical CT scans, and the enhancement patterns and imaging architecture were related to the histologic subtype of the tumors.
  • [MeSH-major] Adenoma / diagnosis. Magnetic Resonance Imaging / methods. Parotid Gland / pathology. Parotid Gland / radiography. Parotid Neoplasms / diagnosis. Tomography, Spiral Computed / methods

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  • (PMID = 16272868.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; JR13W81H44 / Iopamidol
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44. Maruyama S, Cheng J, Shingaki S, Tamura T, Asakawa S, Minoshima S, Shimizu Y, Shimizu N, Saku T: Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland. BMC Cancer; 2009;9:247
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland.
  • BACKGROUND: Among the salivary gland carcinomas, carcinoma in pleomorphic adenoma has been regarded as a representative carcinoma type which arises secondarily in the background of a pre-existent benign pleomorphic adenoma.
  • It is still poorly understood how and which benign pleomorphic adenoma cells transform into its malignant form, carcinoma ex pleomorphic adenoma.
  • METHODS: We have established five cell systems from a benign pleomorphic adenoma of the parotid gland of a 61-year-old woman.
  • RESULTS: We established and characterized five cell systems (designated as SM-AP1 to SM-AP5) from a benign pleomorphic adenoma of the parotid gland.
  • In addition, they had ductal arrangements or plasmacytoid appearances of tumor cells and myxoid or hyaline stromata, indicating some characteristics of pleomorphic adenoma.
  • CONCLUSION: This study demonstrates in vitro that certain cell types from pleomorphic adenoma are able to clone and survive over a long term and develop subcutaneous tumors in nude mice.
  • The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Carcinoma / metabolism. Carcinoma / secondary. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / secondary
  • [MeSH-minor] Animals. Chromosomes, Artificial, Bacterial. DNA Mutational Analysis. Female. Genes, p53. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence. Mice. Mice, Nude. Microscopy, Fluorescence / methods. Middle Aged. Neoplasm Transplantation. Tumor Cells, Cultured


45. Patel RS, Rose B, Bawdon H, Hong A, Lee CS, Fredericks S, Gao K, O'Brien CJ: Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland. Histopathology; 2007 Nov;51(5):691-6
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  • [Title] Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland.
  • AIMS: To compare cyclin D1 and p16(ink4) (p16) expression in normal tissue, pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland.
  • METHODS AND RESULTS: Immunohistochemistry was used to examine cyclin D1 and p16 expression in 43 parotid tumours (29 PAs and 14 CXPAs).
  • Cyclin D1 was more likely to be expressed in the malignant components of CXPA than in the benign components of PA (50% versus 31% and 31%, respectively), but the trend was not statistically significant.
  • [MeSH-major] Adenoma, Pleomorphic / metabolism. Carcinoma / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Cyclins / metabolism. Parotid Gland / metabolism. Parotid Neoplasms / metabolism

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  • (PMID = 17927591.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin D; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclins
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46. Kato H, Kanematsu M, Mizuta K, Ito Y, Hirose Y: Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. AJNR Am J Neuroradiol; 2008 May;29(5):865-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging.
  • We present 4 cases of carcinoma ex pleomorphic adenoma of the parotid gland.
  • In 3 of the 4 cases, diffusion-weighted and apparent diffusion coefficient (ADC) mapping images clearly revealed carcinoma as a hypercellular area with low ADC values and pleomorphic adenoma as a hypocellular area with high ADC values.
  • Diffusion-weighted images demonstrated well complex tissue components in carcinoma ex pleomorphic adenoma, which may be useful for the diagnosis of this disease.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Magnetic Resonance Imaging / methods. Parotid Neoplasms / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 18272554.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Sabesan T, Ramchandani PL, Hussein K: Metastasising pleomorphic adenoma of the parotid gland. Br J Oral Maxillofac Surg; 2007 Jan;45(1):65-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasising pleomorphic adenoma of the parotid gland.
  • A 33-year-old man had a left superficial parotidectomy for a pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Lymphatic Metastasis / pathology. Parotid Neoplasms / pathology

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  • (PMID = 15939513.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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48. Chen AM, Garcia J, Bucci MK, Quivey JM, Eisele DW: The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):138-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland.
  • PURPOSE: To evaluate the impact of postoperative radiation therapy on the clinical course of patients with carcinoma ex pleomorphic adenoma of the parotid gland.
  • METHODS AND MATERIALS: Between 1960 and 2004, 63 patients were treated with definitive surgery for carcinoma ex pleomorphic adenoma of the parotid gland.
  • CONCLUSION: Surgery followed by postoperative radiation should be considered the standard of care for patients with carcinoma ex pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / radiotherapy. Parotid Neoplasms / radiotherapy
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / surgery. Combined Modality Therapy / methods. Female. Humans. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Radiotherapy Dosage. Salivary Ducts. Salivary Gland Neoplasms / mortality. Salivary Gland Neoplasms / radiotherapy. Salivary Gland Neoplasms / surgery

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  • (PMID = 17049183.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Rammeh-Rommani S, Trabelsi A, Stita W, Mokni M, Jaidane L, Yakoubi MT, Moatemri R, Korbi S: [Myoepithelial carcinoma ex-pleomorphic adenoma of the parotid gland]. Rev Stomatol Chir Maxillofac; 2007 Nov;108(5):465-7
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  • [Title] [Myoepithelial carcinoma ex-pleomorphic adenoma of the parotid gland].
  • [Transliterated title] Carcinome myoépithélial ex-adénome pléomorphe de la parotide.
  • INTRODUCTION: Myoepithelial carcinoma accounts for less than 1% of salivary gland malignant tumors.
  • It may develop de novo or, in approximately 50% of the cases, from a pleomorphic adenoma.
  • OBSERVATION: A 57-year-old man with a history of a pleomorphic adenoma of the parotid treated surgically 6 years earlier, presented with a 2 cm tumor mass, palpable in the scar region.
  • There was no evidence of recurrent tumor or of distant metastasis at 4 year follow-up.
  • DISCUSSION: Although myoepithelial cells are often predominant in pleomorphic adenomas, carcinomas developing in pleomorphic adenomas show in most cases a glandular differentiation and myoepithelial carcinomas are rare.
  • Invasive carcinomas developing in pleomorphic adenoma are known to be highly aggressive neoplasms and myoepithelial carcinomas ex-pleomorphic adenoma seem to have a better prognosis.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17884120.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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50. Sheedy SP, Welker KM, DeLone DR, Gilbertson JR: CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol; 2006 Aug;27(7):1483-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland.
  • Pleomorphic adenomas (PAs), also known as benign mixed tumors, are common tumors of the parotid gland.
  • This case report presents the clinical and radiographic features of a rare case of biopsy proved brain and spinal cord metastases arising from carcinoma ex PA of the parotid gland.
  • [MeSH-major] Adenocarcinoma / secondary. Adenoma, Pleomorphic / pathology. Brain Neoplasms / secondary. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Spinal Cord Neoplasms / secondary

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  • (PMID = 16908563.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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51. Nouraei SA, Hope KL, Kelly CG, McLean NR, Soames JV: Carcinoma ex benign pleomorphic adenoma of the parotid gland. Plast Reconstr Surg; 2005 Oct;116(5):1206-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma ex benign pleomorphic adenoma of the parotid gland.
  • BACKGROUND: Carcinoma in pleomorphic salivary adenoma is a common histologic subtype of primary parotid malignancy.
  • METHODS: In this study, 28 patients (predominantly male) with histologically diagnosed carcinoma in pleomorphic salivary adenoma presenting over 10 years were retrospectively reviewed.
  • RESULTS: Only 25 percent of patients had a previously treated pleomorphic salivary adenoma.
  • Although the presenting features suggested malignancy in some cases, overall they were nonspecific, overlapping with the presentation of benign disease.
  • The facial nerve was resected en bloc with the tumor in nine cases and immediately reconstructed with good reanimation results in patients with recent-onset facial paresis.
  • Only 44 percent of patients had a complete histologic tumor clearance, and this was the most significant determinant of survival (p < 0.01, log-rank analysis).
  • CONCLUSIONS: Carcinoma in pleomorphic salivary adenoma is very difficult to diagnose preoperatively.
  • Fine needle aspiration cytology had a disappointingly low sensitivity for this tumor, potentially misdirecting surgical management.
  • While good locoregional disease control could be achieved with surgery and radiotherapy, carcinoma in pleomorphic salivary adenoma was shown to be aggressive with a high disease-specific rate of mortality.
  • Given that incomplete tumor resection was the most important prognostic factor, a high index of clinical suspicion, radical ablative surgery, and immediate soft-tissue and nerve reconstruction for proven cases are advocated.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Parotid Neoplasms / surgery

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  • (PMID = 16217459.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Kato H, Kanematsu M, Ando K, Mizuta K, Ito Y, Hirose Y, Hoshi H: Ossifying pleomorphic adenoma of the parotid gland: a case report and review. Australas Radiol; 2007 Dec;51 Suppl:B173-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ossifying pleomorphic adenoma of the parotid gland: a case report and review.
  • Pleomorphic adenoma is the most common parotid gland neoplasm and occasionally arises from the deep lobe of the parotid gland with extension into the parapharyngeal space.
  • However, ossification of pleomorphic adenoma is rare, although chondroid and myxochondroid tissue formation is frequently seen histologically.
  • We report an unusual case of ossifying pleomorphic adenoma arising from the deep lobe of the parotid gland in the parapharyngeal space.
  • [MeSH-major] Adenoma, Pleomorphic / radiography. Ossification, Heterotopic / radiography. Parotid Gland / radiography. Parotid Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 17991056.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 6
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53. Lüers JC, Wittekindt C, Streppel M, Guntinas-Lichius O: Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol; 2009;48(1):132-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy.
  • BACKGROUND: Carcinoma ex pleomorphic adenoma (CXPA) is a rare parotid malignancy and until today no standardized concept exists for its therapy apart from recommendations for parotid carcinoma in general.
  • Prognosis is thought to be poorer than for other parotid malignancies.
  • METHODS: We retrospectively analysed the courses of 22 patients with a CXPA of the parotid gland treated at a tertiary medical care centre for otorhinolaryngology.
  • RESULTS: About half of the patients had evidence of a parotid mass of up to 1 year only while maximum of the others was 48 years.
  • CONCLUSION: Surgical therapy (total or radical parotidectomy) is the method of choice for CXPA of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / therapy. Carcinoma / diagnosis. Carcinoma / therapy. Parotid Neoplasms / diagnosis. Parotid Neoplasms / therapy

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  • (PMID = 18607845.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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54. Zbären P, Stauffer E: Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors. Head Neck; 2007 Aug;29(8):751-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the parotid gland: histopathologic analysis of the capsular characteristics of 218 tumors.
  • BACKGROUND: Histopathologic features of the capsule may have an impact on the recurrence rate of pleomorphic adenomas.
  • METHODS: Retrospective (n = 154) and prospective (n = 64) histologic analysis of the capsular characteristics such as incompleteness, tumor penetration, pseudopodia, and satellite tumors of 218 pleomorphic adenomas.
  • RESULTS: In 160 of the 218 (73%) pleomorphic adenomas, 1 or more capsular characteristics such as incomplete capsule (33%), capsule penetration (26%), pseudopodia (40%), and satellite nodules (13%) were detected.
  • If left in the surrounding salivary gland tissue at surgery, they can lead to recurrences of pleomorphic adenomas of the parotid gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 17252593.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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55. Shehata EA: Extra-capsular dissection for benign parotid tumours. Int J Oral Maxillofac Surg; 2010 Feb;39(2):140-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extra-capsular dissection for benign parotid tumours.
  • The most common benign tumour of the parotid is pleomorphic adenoma (PA).
  • This study aimed to evaluate the morbidity associated with ECD in managing benign parotid tumours and to demonstrate that the technique can be used outside specialist centres.
  • Twenty-six consecutive patients, diagnosed with benign parotid gland tumours were treated by ECD.
  • Their benign status was determined by history, clinical criteria and fine needle aspiration cytology.
  • Inclusion criteria were a discrete mobile lump, more than 3 cm in diameter and clinical/histological evidence of benign biological behaviour.
  • In 23 patients, the tumour was located entirely within the superficial lobe of the parotid.
  • ECD seems to be an alternative to superficial parotidectomy for most superficial parotid lumps.
  • [MeSH-major] Dissection / methods. Parotid Neoplasms / surgery
  • [MeSH-minor] Adenolymphoma / pathology. Adenolymphoma / surgery. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Adult. Aged. Biopsy, Fine-Needle. Facial Nerve Injuries / etiology. Facial Paralysis / etiology. Female. Follow-Up Studies. Hematoma / etiology. Humans. Intraoperative Complications. Male. Middle Aged. Minimally Invasive Surgical Procedures. Parotid Gland / innervation. Postoperative Complications. Postoperative Hemorrhage / etiology. Prospective Studies. Rupture, Spontaneous. Time Factors

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  • [Copyright] Copyright 2009 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20053535.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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56. Ide F, Mishima K, Yamada H, Saito I: Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland. Head Neck Pathol; 2009 Jun;3(2):159-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland.
  • There is a considerable variation in the histologic subtype of epithelial malignancies among carcinoma ex pleomorphic adenomas (CXPA) and virtually any known carcinoma entity can develop.
  • To our knowledge, adenoid cystic carcinoma (AdCC) ex PA is quite rare despite the fact that de novo AdCC is the fourth most common salivary gland malignancy.
  • We describe a new case of AdCC ex PA in the parotid gland of a 62 year-old woman.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Adenoid Cystic / pathology. Parotid Neoplasms / pathology

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  • [Cites] Acta Otolaryngol. 1968 Dec;66(6):477-92 [4308066.001]
  • [Cites] Cancer. 1968 Jun;21(6):1198-211 [4296747.001]
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  • (PMID = 19644550.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Carcinoma ex pleomorphic adenoma / High-grade malignancy / Parotid gland
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57. Philpott CM, Kendall C, Murty GE: Canalicular adenoma of the parotid gland. J Laryngol Otol; 2005 Jan;119(1):59-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Canalicular adenoma of the parotid gland.
  • Canalicular adenomas are a rare form of benign tumour that occur in salivary glands, occurring mainly in the upper lip and minor salivary glands of the buccal mucosa.
  • The authors report the fifth case and the first in the otorhinolaryngological literature of a canalicular adenoma of the parotid gland.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 15807970.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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58. Kumar A, Banerjee A: Continuous maxillary and mandibular nerve block for perioperative pain relief: the excision of a complicated pleomorphic adenoma. Anesth Analg; 2005 Nov;101(5):1531-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Continuous maxillary and mandibular nerve block for perioperative pain relief: the excision of a complicated pleomorphic adenoma.
  • A 68-yr-old hypertensive patient with ischemic heart disease and intractable atrial fibrillation with stable hemodynamics and poor chest compliance underwent pleomorphic adenoma of the parotid gland using regional anesthesia with continuous propofol sedation.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Mandibular Nerve. Maxillary Nerve. Nerve Block / methods. Pain, Postoperative / therapy

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  • (PMID = 16244026.001).
  • [ISSN] 0003-2999
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Parwani AV, Lujan G, Ali SZ: Myoepithelial carcinoma arising in a pleomorphic adenoma of the parotid gland: report of a case with cytopathologic findings. Acta Cytol; 2006 Jan-Feb;50(1):93-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myoepithelial carcinoma arising in a pleomorphic adenoma of the parotid gland: report of a case with cytopathologic findings.
  • BACKGROUND: Carcinoma arising in a mixed tumor, or carcinoma ex pleomorphic adenoma (CEPA), is an uncommon primary salivary gland neoplasm.
  • CASE: A 76-year-old woman presented with an incidental parotid/parapharyngeal mass.
  • Computed tomography-guide fine needle aspiration (FNA) showed a biphasic neoplasm with epithelial and stromal components consistent with pleomorphic adenoma (PA).
  • However, in addition, a distinct population of discohesive atypical and pleomorphic cells with high nuclear/cytoplasmic ratio was noted in the background.
  • Subsequent resection of the parotid mass confirmed the presence of low grade myoepithelial carcinoma arising in a PA.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Carcinoma / diagnosis. Myoepithelioma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 16514848.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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60. Al Bisher H: A rare case of primary tuberculosis infection with concurrent pleomorphic adenoma of the parotid gland. Infect Dis Rep; 2010 Feb 3;2(1):e6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of primary tuberculosis infection with concurrent pleomorphic adenoma of the parotid gland.
  • Coexistence of parotid tuberculosis along with a benign parotid tumor is a rare entity with only nine cases reported in the literature.
  • We report here a case of primary parotid tuberculosis with concurrent pleomorphic adenoma in a 51-year-old female.

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  • (PMID = 24470888.001).
  • [ISSN] 2036-7430
  • [Journal-full-title] Infectious disease reports
  • [ISO-abbreviation] Infect Dis Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3892577
  • [Keywords] NOTNLM ; parotid gland. / pleomorphic adenoma / primary tuberculosis
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61. Ghosh A, Arundhati, Asthana AK: Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report. Acta Cytol; 2008 Nov-Dec;52(6):733-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pleomorphic adenoma of the parotid gland metastasizing to the scapular region: a case report.
  • BACKGROUND: Metastasizing pleomorphic adenoma (MPA) is a rare, incompletely understood enigmatic entity having the histologic appearance of benign pleomorphic adenoma and clinically malignant behavior.
  • We report a case of MPA of the parotid gland that metastasized to the scapular region 6 years after the appearance of the primary lesion in the left parotid gland.
  • CASE: A 35-year-old woman presented with a palpable soft to firm mass of 3-cm diameter in the left scapular region that was slightly mobile over the underlying structures and a small swelling at the operated site of the parotid region.
  • The patient had a prior history of surgical removal of recurrent pleomorphic adenoma of the left parotid salivary gland.
  • Fine needle aspiration cytology (FNAC) smears of both sites demonstrated the 3 components (i.e., stromal, mesenchymal and epithelial) of benign pleomorphic adenoma with benign features.
  • CONCLUSION: The appearance of a mass lesion or subcutaneous nodule with a prior history of pleomorphic adenoma should alert for the possibilities of metastatic carcinoma, metastatic carcinosarcoma and MPA.
  • With well-established cytomorphology of pleomorphic adenoma, FNAC remains the investigation method of choice for metastatic workup of a case of locally recurrent pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology. Scapula

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  • (PMID = 19068682.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Zhao DM, He HW, Liu MY, He ZX: [Tumors of different histological type in unilateral salivary glands: a case report]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2010 Dec;28(6):680-1, 683

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tumors of synchronous benign and malignant in unilateral salivary glands have rarely been reported.
  • A case of 21-year-old girl who was diagnosed as synchronously adenoid cystic carcinoma of the left parotid and pleomorphic adenoma of the left submandibular gland.
  • [MeSH-major] Adenoma, Pleomorphic. Carcinoma, Adenoid Cystic

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  • (PMID = 21365854.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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63. de Vicente Rodríguez JC, Fresno Forcelledo MF, González García M, Aguilar Andrea C: Sebaceous adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal; 2006 Aug;11(5):E446-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous adenoma of the parotid gland.
  • The majority of salivary gland neoplasms are benign, with malignant salivary tumors accounting for 15 to 32 percent.
  • The most common site for salivary gland tumors is the parotid gland, accounting up to 80 percent of all cases.
  • This article reports the pathologic picture in a case of sebaceous adenoma of the parotid gland.
  • The tumor was composed of epithelial cells lining ducts and closely associated with broad areas of sebaceous differentiation.
  • To the surgeon and pathologist, the major problem in dealing with sebaceous adenoma is the recognition of this rare entity, avoiding confusing with other more aggressive neoplasms.
  • The addition of the current case to the previously published data brings the total number of parotid sebaceous adenoma to seven.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16878064.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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64. Palmieri A, Carinci F, Martinelli M, Spinelli G, Lo Muzio L, Rubini C, Scapoli L: Absence of Simian virus 40, BK, and JC polyomavirus DNA in squamous cell carcinoma limited to the oral cavity. Head Neck; 2010 Mar;32(3):375-80
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The Simian virus 40 (SV40), which is a polyomavirus known for its oncogenic potential, was found as a contaminant of oral vaccines and has been related to human pleomorphic adenoma in the parotid gland.


65. Miliauskas JR, Hunt JL: Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review. Head Neck Pathol; 2008 Dec;2(4):339-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review.
  • Multiple separate tumors developing in a single salivary gland is rare in previously untreated patients.
  • Tumors that can be multicentric include Warthin tumor, oncocytoma, basal cell adenoma and acinic cell carcinoma.
  • The incidence of multiple primary unilateral pleomorphic adenomas is extremely rare in patients with no prior history of trauma or surgery.
  • We report two cases of primary multicentric pleomorphic adenoma and review the literature.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Loss of Heterozygosity. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology

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  • (PMID = 20614306.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2807582
  • [Keywords] NOTNLM ; Multifocal / Parotid gland / Pleomorphic adenoma
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66. Khadse P, Prabhash K, Pramesh CS, Chaturvedi P, Shet T: Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma. Diagn Cytopathol; 2009 Sep;37(9):680-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma.
  • Malignant mixed tumor of the parotid is known to have odd sites for metastases.
  • We describe the fine-needle aspiration cytology (FNAC) findings of pleural metastasis from a malignant mixed tumor misdiagnosed as a mesothelioma on cytology at the onset.A 47-year-old man presented to us with breathlessness and a massive pleural effusion with pleural-based nodules.
  • He had been operated 2 years before for a pleomorphic adenoma of the parotid and had a healthy scar at that site.
  • While on chemotherapy tumor recurred at the primary site in parotid and was confirmed to be a carcinosarcoma on a FNAC and biopsy.To conclude, pleural metastases from a true malignant mixed tumor of the parotid gland can be misdiagnosed as mesothelioma and could occur in the absence of uncontrolled disease at primary site.
  • Both mesotheliomas and pleomorphic adenomas metastatic to the pleura are biphasic tumors, but in a patient with history of pleomorphic adenoma, the latter should be kept as a foremost possibility.
  • Attention to the cytomorphology of tumor cells will also assist in confirming the diagnosis.
  • [MeSH-major] Carcinosarcoma / secondary. Mesothelioma / pathology. Neoplasms, Complex and Mixed / secondary. Parotid Neoplasms / pathology. Pleural Neoplasms / secondary

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19373913.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; Q20Q21Q62J / Cisplatin
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67. Bień S, Sygut J, Kopczyński J, Postuła S, Ziółkowska M: [Salivary duct carcinoma--a clinicopathological analysis of five cases]. Otolaryngol Pol; 2007;61(1):33-8
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  • The 5 cases of salivary duct carcinoma (SDC); very rare, but distinct group of highly malignant salivary gland tumor are presented, and difficulties with pathological and clinical diagnosis is discussed.
  • The SDC developed in single cases in parotid salivary gland, submandibular salivary and in mucosa of maxillary sinus, pyriform fossa and oral cavity (check).
  • In 3 cases the second malignant tumor was present--synchronously (SDC + pleomorphic adenoma in parotid gland; SDC + squamous cell carcinoma in hypopharynx) or metachroneously (squamous cell carcinoma of upper lip followed by SDC).
  • In one case the high levels of PSA suggesting of metastases from unknown primary within the prostate gland, or PSA expression related to SDC was observed.
  • [MeSH-major] Carcinoma, Ductal / pathology. Carcinoma, Ductal / therapy. Salivary Ducts / pathology. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / therapy

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  • (PMID = 17605416.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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68. Liess BD, Lane RV, Frazier S, Zitsch RP 3rd: Bilateral canalicular adenoma of the parotid gland. Arch Otolaryngol Head Neck Surg; 2006 Mar;132(3):339-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral canalicular adenoma of the parotid gland.
  • Canalicular adenoma is a rare benign salivary gland tumor that occurs almost exclusively in the upper lip.
  • Rarely, this benign tumor may occur multifocally in the oral cavity.
  • We report a case of canalicular adenoma in bilateral parotid glands, discuss histological characteristics, and review this tumor.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16549756.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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69. Redaelli de Zinis LO, Piccioni M, Antonelli AR, Nicolai P: Management and prognostic factors of recurrent pleomorphic adenoma of the parotid gland: personal experience and review of the literature. Eur Arch Otorhinolaryngol; 2008 Apr;265(4):447-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management and prognostic factors of recurrent pleomorphic adenoma of the parotid gland: personal experience and review of the literature.
  • The aim of this study was to investigate the management and prognostic determinants of recurrent pleomorphic adenoma (RPA).
  • Tumor recurrence rate was estimated by the Kaplan-Meier method, and the prognostic value of some of the variables was tested by univariate analysis using the log rank test.
  • The estimated tumor recurrence rates were 14.1+/-6.6% at 5 years, 31.4+/-9.4% at 10 years, 43.0+/-10.8% at 15 years, and 57.2+/-14.8% at 20 years.
  • [MeSH-major] Adenoma, Pleomorphic. Neoplasm Recurrence, Local. Otorhinolaryngologic Surgical Procedures / methods. Parotid Neoplasms

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  • (PMID = 17960409.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2254466
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70. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C: Basal cell adenoma of the parotid gland. Case report and review of the literature. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E206-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland. Case report and review of the literature.
  • Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma.
  • Its most frequent location is the parotid gland.
  • In contrast to pleomorphic adenoma, it tends to be multiple and its recurrence rate after surgical excision is high.
  • We describe a case of basal cell adenoma of the parotid gland.
  • [MeSH-major] Adenoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16505803.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 21
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71. Palomar Asenjo V, Borràs Perera M, Soteras Ollé J, Palomar García V: [Parotid gland myoepitheliomas. Differential diagnosis with pleomorphic adenoma]. An Otorrinolaringol Ibero Am; 2006;33(4):409-16

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Parotid gland myoepitheliomas. Differential diagnosis with pleomorphic adenoma].
  • [Transliterated title] Mioepiteliomas de glándula parótida. Diagnóstico diferencial con el adenoma pleomorfo.
  • Myoepitheliomas are rare benign tumours of head and neck.
  • The parotid gland is the most common site of origin.
  • It consists on proliferation of myoepithelial cells and it shows some features similar to preomorphic adenoma although the ductal elements are very low.
  • We report two cases of parotid gland myoepithelioma confirmed by immunohistochemistry.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Myoepithelioma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16910397.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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72. Yerli H, Teksam M, Aydin E, Coskun M, Ozdemir H, Agildere AM: Basal cell adenoma of the parotid gland: dynamic CT and MRI findings. Br J Radiol; 2005 Jul;78(931):642-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland: dynamic CT and MRI findings.
  • Imaging findings in basal cell adenoma (BCA) of the parotid gland have been rarely reported.
  • We report dynamic CT and MRI findings of BCA in the parotid gland in a 78-year-old woman.
  • [MeSH-major] Adenoma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 15961849.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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73. Kawata R, Yoshimura K, Lee K, Araki M, Takenaka H, Tsuji M: Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor. Eur Arch Otorhinolaryngol; 2010 May;267(5):779-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor.
  • The aim of this study is to investigate the clinical and pathological characteristics of basal cell adenoma (BCA) and to compare the diagnosis/treatment of BCA with those of Warthin's tumor (WT) and pleomorphic adenoma (PA).
  • Among 192 patients with benign tumors of the parotid gland who underwent surgery, 9 had BCA.
  • All of these tumors showed a benign pattern on computed tomography and magnetic resonance imaging.
  • Most PA and BCA lesions developed in the upper part of the parotid gland.
  • Considering the gender difference, tumor site, and age, it is necessary to differentiate BCA from PA rather than from WT.
  • BCA is the third most common of the benign parotid tumors, following WT and PA, although its incidence is low.
  • When PA and WT are ruled out by FNAB after a tentative diagnosis of benign tumor has been based on imaging findings, BCA should be considered.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma / pathology. Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19908055.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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74. Sergi B, Limongelli A, Scarano E, Fetoni AR, Paludetti G: Giant deep lobe parotid gland pleomorphic adenoma involving the parapharyngeal space. Report of three cases and review of the diagnostic and therapeutic approaches. Acta Otorhinolaryngol Ital; 2008 Oct;28(5):261-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant deep lobe parotid gland pleomorphic adenoma involving the parapharyngeal space. Report of three cases and review of the diagnostic and therapeutic approaches.
  • Aim of the present report is to discuss and underline the diagnostic algorithm and the surgical approach to giant parotid pleomorphic adenomas arising in the deep lobe and growing in the parapharyngeal space.
  • Three cases are described and a review is made of the international literature concerning giant deep lobe parotid gland pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19186458.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 24
  • [Other-IDs] NLM/ PMC2689534
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75. Patel RS, Hughes CW, Fredericks S, Lee CS, Rose B, Gao K, Smith G, Hong A, O'Brien CJ: Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland. Histopathology; 2007 Jul;51(1):21-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland.
  • AIMS: To investigate cyclin A expression in pleomorphic adenoma (PA) and carcinoma expleomorphic adenoma (CXPA) of the parotid gland with a view to assessing its potential value as a diagnostic marker for CXPA.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Cyclin A / metabolism. Parotid Neoplasms / diagnosis. Parotid Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Case-Control Studies. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Gene Expression Regulation, Neoplastic. Humans. Parotid Gland / metabolism. Parotid Gland / pathology

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  • (PMID = 17593077.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin A
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76. Hernández Sandemetrio R, Armengot Carceller M, Alba García JR, Taleb C, Jiménez Roig JP, Frías Moya-Angeler S, Basterra Alegría J: [Pleomorphic adenoma of deep lobe of the parotid gland]. Acta Otorrinolaringol Esp; 2006 Jan;57(1):56-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pleomorphic adenoma of deep lobe of the parotid gland].
  • [Transliterated title] Adenoma pleomorfo gigante de lóbulo profundo de la parótida: a propósito de un caso.
  • This report describes a case of a pleomorphic adenoma in the deep lobe of the parotid gland presented like a parapharyngeal mass, and its diagnosis and treatment.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16503035.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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77. Vázquez Mahía I, López-Cedrún Cembranos JL, Ferreras Granado J, Lorenzo Franco F: Temporomandibular juxtaarticular chondroma: case report. Med Oral Patol Oral Cir Bucal; 2007 Mar;12(2):E171-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Chondromas are benign tumours composed of mature hyaline cartilage.
  • We present here the first case in the English language medical literature of juxtaarticular chondroma of the temporomandibular joint in the parotid region.
  • The diagnostic possibilities of a parotid pleomorphic adenoma and of a cartilage tumour of the TMJ suggested a difficult preoperative differential diagnosis, which influenced our approach regarding therapy.
  • The tumour was excised, preserving the parotid gland.
  • [MeSH-major] Chondroma / pathology. Parotid Neoplasms / pathology. Temporomandibular Joint

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  • (PMID = 17322809.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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78. Karakoc O, Akcam T, Kocaoglu M, Yetiser S: Agenesis of the unilateral parotid gland associated with pleomorphic adenoma of the contralateral parotid gland. J Laryngol Otol; 2005 May;119(5):409-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Agenesis of the unilateral parotid gland associated with pleomorphic adenoma of the contralateral parotid gland.
  • Congenital absence of the parotid gland is extremely infrequent.
  • We present here a case of unilateral parotid gland agenesis with pleomorphic adenoma of the contralateral parotid gland.
  • Even though pleomorphic adenoma is the most common tumour of the parotid gland, to our knowledge this is the first case of these two conditions being seen together.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Parotid Gland / abnormalities. Parotid Neoplasms / pathology

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  • (PMID = 15949111.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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79. Nakabayashi M, Shomori K, Kiya S, Shiomi T, Nosaka K, Ito H: Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report. Yonago Acta Med; 2010 Sep;53(3):65-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report.
  • Basal cell adenoma (BCA) is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells.
  • We report on a female patient with BCA that developed in the right parotid gland in her 50s.
  • The present patient demonstrated a few tumor nests in the fibrous capsule, and her tumor was larger than usual.
  • Histopathologically, the tumor was characterized by multiple duct-like structures and tubular-trabecular masses composed of small isomorphic cells with hyperchromatic, round nuclei and an eosinophilic cytoplasm.
  • It was difficult to determine whether the ductal structures noted in the tumor capsule were invasive.
  • By immunohistochemistry, tumor cells of the tubular nests were positive for cytokeratin 7 and that the outer cells of tubular nests were positive for alpha smooth muscle actin (αSMA) and calponin.
  • Tumor cells were immuno-negative for S-100 protein and glial fibrillary acidic protein.

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  • (PMID = 24031120.001).
  • [ISSN] 0513-5710
  • [Journal-full-title] Yonago acta medica
  • [ISO-abbreviation] Yonago Acta Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3763784
  • [Keywords] NOTNLM ; basal cell adenoma / immunohistochemistry / parotid gland
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80. Apple SK, Moatamed NA, Lai CK, Bhuta S: Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation. Acta Cytol; 2009 Jul-Aug;53(4):419-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sebaceous adenoma of the parotid gland: a case report with fine needle aspiration findings and histologic correlation.
  • BACKGROUND: Sebaceous adenoma of the salivary gland is an extremely rare, benign neoplasm that predominantly involves the major salivary glands.
  • The major problem in dealing with sebaceous adenoma is the recognition of this entity to avoid confusion with other more aggressive neoplasms, such as mucoepidenmoid carcinoma.
  • CASE: A 29-year-old woman presented with an enlarging parotid mass.
  • CONCLUSION: We report a case ofa rare and unusual tumor of the salivary glands.
  • The major problem in dealing with sebaceous adenoma is the recognition ofthis entity in cytologic specimens to avoid confusion with other more aggressive neoplasms such as low grade mucoepidermoid carcinoma and potentially to avoid radical surgery.
  • [MeSH-major] Adenoma / pathology. Biopsy, Fine-Needle. Parotid Neoplasms / pathology

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  • (PMID = 19697727.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Nepal A, Chettri ST, Joshi RR, Bhattarai M, Ghimire A, Karki S: Primary salivary gland tumors in eastern Nepal tertiary care hospital. J Nepal Health Res Counc; 2010 Apr;8(1):31-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary salivary gland tumors in eastern Nepal tertiary care hospital.
  • BACKGROUND: The knowledge of the distribution and pattern of salivary gland tumors in the tertiary care center can provide overview of the disease pattern in the region.
  • METHODS: A retrospective observational study of all the salivary gland tumors treated in the department of Otolaryngology, B. P.
  • Age, sex, presenting features, radiological findings, histopathological type of the tumor and type of surgery were recorded and descriptive analysis was done to calculate frequencies, percentage and their relations.
  • RESULTS: Out of total 51 cases, 81% (n=41) were benign and 19% (n=10) malignant tumors.
  • Mean age for benign and malignant tumors were 32.3 and 46.5 years respectively.
  • Parotid tumor outnumbered all other sites comprising 69%, followed by submandiibular 18% and minor glands 13%.
  • Pleomorphic adenoma was the commonest tumor (76%) of all primary salivary gland tumors.
  • Benign to malignant tumor ratio of parotid, submandibular and minor glands were 6:1, 3.5:1 and 1.3:1 respectively.
  • CONCLUSIONS: The principal site for salivary gland tumors in eastern Nepal population was the parotid and the pleomorphic adenoma outnumbered all other tumors.
  • Most of the cases in both benign and malignant group presented with painless lump often misleading the gravity of disease.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Middle Aged. Nepal. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Retrospective Studies. Salivary Glands / pathology. Young Adult

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  • (PMID = 21879011.001).
  • [ISSN] 1999-6217
  • [Journal-full-title] Journal of Nepal Health Research Council
  • [ISO-abbreviation] J Nepal Health Res Counc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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82. Okahara M, Kiyosue H, Matsumoto S, Hori Y, Tanoue S, Uchida D, Mori H, Kondo Y: Basal cell adenoma of the parotid gland: MR imaging findings with pathologic correlation. AJNR Am J Neuroradiol; 2006 Mar;27(3):700-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Basal cell adenoma of the parotid gland: MR imaging findings with pathologic correlation.
  • BACKGROUND AND PURPOSE: Basal cell adenomas (BCAs) are rare tumors of the parotid gland.
  • The aim of this study was to describe and characterize the MR findings of BCAs of the parotid gland.
  • On T2-weighted images (T2WI), all of them showed slightly lower SI than that of surrounding parotid tissue.
  • Although BCAs are rare, they should be suspected when a tumor shows all of the characteristics noted here.
  • [MeSH-major] Adenoma / pathology. Magnetic Resonance Imaging. Parotid Neoplasms / pathology

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  • (PMID = 16552019.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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83. Butler C, Kulendra KN, Menon G, D'Souza AR: Canalicular adenoma: a case report of an unusual parotid lesion. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Canalicular adenoma: a case report of an unusual parotid lesion.
  • Histopathological diagnosis revealed a canalicular adenoma of the parotid gland.

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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Mar;87(3):346-50 [10102598.001]
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  • (PMID = 21686469.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027611
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84. Kawahara A, Harada H, Akiba J, Yokoyama T, Kage M: Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfalls. Diagn Cytopathol; 2007 Feb;35(2):85-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: characteristic cytological features and diagnostic pitfalls.
  • We retrospectively studied the cytological features of aspiration cytology in 12 cases of basal cell adenoma (BCA) and 5 cases mistakenly diagnosed as BCA.
  • In contrast, 3 of the 5 cystic type BCA cases showed inadequate cellular components or no basaloid tumor cells, and the cytological diagnosis of BCA could not be determined.
  • In the 5 cases misdiagnosed as BCA, there were 2 cases of pleomorphic adenoma, 2 cases of benign lymphoepithelial cyst, and 1 case of basal cell adenocarcinoma.
  • [MeSH-major] Adenoma / diagnosis. Parotid Neoplasms / diagnosis

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  • (PMID = 17230571.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Fulciniti F, Losito NS, Botti G, Manola M, Ionna F: Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample. Diagn Cytopathol; 2010 Jun;38(6):430-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.
  • One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Adenoma, Pleomorphic / pathology. Infarction / pathology. Parotid Neoplasms / blood supply. Parotid Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19894261.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Zernial O, Springer IN, Warnke P, Härle F, Risick C, Wiltfang J: Long-term recurrence rate of pleomorphic adenoma and postoperative facial nerve paresis (in parotid surgery). J Craniomaxillofac Surg; 2007 Apr;35(3):189-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term recurrence rate of pleomorphic adenoma and postoperative facial nerve paresis (in parotid surgery).
  • BACKGROUND: The purpose of this study was to evaluate recurrence rates and comorbidity in patients with pleomorphic adenomas of patients after superficial and total conservative parotidectomy.
  • PATIENTS AND METHODS: Localization of pleomorphic adenomas, age, sex distribution and facial nerve function of 73 patients were examined in this retrospective study.
  • RESULTS: Most of the patients were female (67%) with a parotid pleomorphic adenoma.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Facial Paralysis / etiology. Neoplasm Recurrence, Local. Oral Surgical Procedures / adverse effects. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 17576069.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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87. Ciecior E, Sowa P, Adamczyk-Sowa M, Wolny A, Mrowka-Kata K: [Huge pleomorphic adenoma of deap lobe origin in the parotid gland]. Otolaryngol Pol; 2009 Sep;63(7):87-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Huge pleomorphic adenoma of deap lobe origin in the parotid gland].
  • Pleomorphic adenoma (PA) is a the most frequent benign tumor of the parotid gland, although in some cases it can turn malignant (3-4%).
  • Usually it grows slow and is removed surgically as a small tumor (average diameter 2-6 cm).
  • In the present paper we presented a case of 38-year-old male patient with PA of parotid glad achieving 10 x 15 cm tumor and of deep lobe origin.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Parotid Gland / surgery. Parotid Neoplasms / surgery

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  • (PMID = 20564909.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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88. Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP: Salivary gland pleomorphic adenoma. Am J Clin Oncol; 2008 Feb;31(1):95-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland pleomorphic adenoma.
  • We discuss the optimal treatment and outcomes for pleomorphic adenoma of the salivary glands by reviewing the pertinent literature.
  • Pleomorphic adenoma is the most common benign salivary gland neoplasm.
  • It is found mostly in the parotid gland in middle-aged women.
  • Local control rates after RT for microscopic and gross residual tumor are approximately 80% to 85% and 40% to 60%, respectively.
  • [MeSH-major] Adenoma, Pleomorphic / therapy. Neoplasm Recurrence, Local / diagnosis. Salivary Gland Neoplasms / therapy

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  • (PMID = 18376235.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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89. Caloglu M, Yurut-Caloglu V, Altaner S, Huseyinova G, Unlu E, Karagol H, Uzal C: Oncocytic carcinoma of the parotid gland. Onkologie; 2006 Sep;29(8-9):388-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncocytic carcinoma of the parotid gland.
  • BACKGROUND: Oncocytic carcinoma is a rare tumor of major salivary glands.
  • Histochemical or electron microscopic confirmation of the oncocytic nature of the tumor cell is needed for differential diagnosis.
  • CASE REPORT: A 58-year old man presented with a recurrent mass in the left parotid gland with a prior diagnosis of monomorphic adenoma in the same localization which had been treated by tumor excision in July 2002.
  • Left superficial parotidectomy followed by radiotherapy into tumor bed and upper neck were carried out in September 2004.
  • CONCLUSION: For an accurate approach in the management of patients, oncocytic adenocarcinoma should be considered in the differential diagnosis of lesions of the parotid gland, most of which are benign.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / therapy. Parotid Neoplasms / pathology. Parotid Neoplasms / therapy

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  • (PMID = 16974117.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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90. Zagólski O, Czajecki K, Gajda M: [Diffuse hyperplastic oncocytosis of the parotid gland]. Pol Merkur Lekarski; 2006 Oct;21(124):356-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diffuse hyperplastic oncocytosis of the parotid gland].
  • An intracellular metabolic disturbance associated with mitochondriopathy, due to an age dependent metabolic defect, is suggested to cause metaplasia of salivary gland cells into oncocytes.
  • The WHO classification of salivary gland diseases considers 3 oncocytic lesions: oncocytosis, oncocytoma and oncocytic carcinoma.
  • In case of diffuse hyperplastic oncocytosis of the parotid gland, extensive metaplasia of acinic and ductal cells leads to transformation of nearly all cells of the gland into oncocytes, which is clinically characterised by swelling of the parotid gland, and is an extremely rare condition.
  • A 82-year-old man (the eldest of all reported) presented with a 2-month history of increasing diffuse swelling of the left parotid gland, 6 cm in diameter.
  • The mass was soft, painless to palpation and grew in the superficial lobe of the parotid gland.
  • Histopathological examination of the operative specimen disclosed oncocytosis of the salivary gland.
  • Surgical removal of the diffuse hyperplastic oncocytosis of the parotid gland, with indications and extent of the resection like in benign tumors, was effective in the presented patient.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Parotid Gland / pathology. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / surgery

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  • (PMID = 17205777.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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91. Stomeo F, Meloni F, Bozzo C, Fois V, Pastore A: Bilateral oncocytoma of the parotid gland. Acta Otolaryngol; 2006 Mar;126(3):324-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral oncocytoma of the parotid gland.
  • Oncocytic neoplasms are a group of rare tumours that mostly affect the parotid gland (80%), sometimes affect the submandibular gland (9%) and rarely affect the intraoral minor salivary glands.
  • The incidence of oncocytic neoplasms represents approximately 1% of parotid neoplasms and bilateral presentation is very rare.
  • Herein we describe a single case involving bilateral presentation of oncocytoma of the parotid glands.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / surgery

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  • (PMID = 16618664.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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92. Musani MA, Sohail Z, Zafar S, Malik S: Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak; 2008 May;18(5):274-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphological pattern of parotid gland tumours.
  • OBJECTIVE: To determine the morphological pattern of parotid tumours.
  • PATIENTS AND METHODS: During this study, 204 patients with parotid tumours were registered.
  • RESULTS: Out of 204 cases, 152 (74.5%) were benign and 52 (25.5%) were malignant.
  • Benign tumours were more common in females whereas malignant tumours were common in males.
  • The mean age of patients was 34 years and 42 years for benign and malignant tumours respectively.
  • Pleomorphic adenoma was most common benign tumor (83.5%), followed by Warthins tumour.
  • Superficial lobe of parotid gland was the commonest site, 120 benign and all 52 malignant tumours arising from it while 32 benign tumours originated from deep lobe.
  • Parotid swelling for years was main feature of benign tumours, whereas malignant tumours presented with pain, fixation to skin or underlying structure, cervical lymphadenopathy and facial palsy.
  • CONCLUSION: Pleomorphic adenoma was the most common benign tumour and mucoepidermoid carcinoma was most common malignant tumour.
  • [MeSH-major] Parotid Neoplasms / diagnosis

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  • (PMID = 18541080.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Pakistan
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93. Tanaka S, Tabuchi K, Oikawa K, Kohanawa R, Okubo H, Ikebe D, Noguchi M, Hara A: Synchronous unilateral parotid gland neoplasms of three different histological types. Auris Nasus Larynx; 2007 Jun;34(2):263-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous unilateral parotid gland neoplasms of three different histological types.
  • A 67-year-old male with three synchronous tumors in the unilateral parotid gland is reported.
  • Postoperative histological examinations confirmed the presence of three synchronous primary tumors, specifically pleomorphic adenoma, Warthin's tumor and salivary duct carcinoma, in the right parotid gland.
  • To our knowledge, this is the first case report describing three different histological types in the unilateral parotid gland.
  • [MeSH-major] Adenolymphoma / pathology. Adenoma, Pleomorphic / pathology. Carcinoma / pathology. Neoplasms, Multiple Primary / pathology. Parotid Neoplasms / pathology. Salivary Ducts / pathology
  • [MeSH-minor] Aged. Humans. Male. Parotid Gland / pathology

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  • (PMID = 16938417.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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94. Lee BH: Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space. Jpn J Radiol; 2010 Apr;28(3):224-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral agenesis of the parotid gland associated with a pleomorphic adenoma in the ipsilateral buccal space.
  • Unilateral agenesis of the parotid gland is a rare condition.
  • Although pleomorphic adenomas are the most common benign glandular tumors of the buccal space, to the author's knowledge unilateral agenesis of the parotid gland associated with pleomorphic adenoma in the ipsilatearal buccal space has not been previously described in the literature.
  • [MeSH-major] Adenoma, Pleomorphic / diagnostic imaging. Cheek. Parotid Gland / abnormalities
  • [MeSH-minor] Aged. Female. Humans. Salivary Gland Neoplasms / diagnostic imaging. Salivary Glands, Minor. Tomography, X-Ray Computed

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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Mar;105(3):e73-5 [18280951.001]
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  • (PMID = 20437134.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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95. Jezewska E, Scinska A, Kukwa W, Bienkowski P: Effects of benign parotid tumors on unstimulated saliva secretion from the parotid gland. Auris Nasus Larynx; 2009 Oct;36(5):586-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of benign parotid tumors on unstimulated saliva secretion from the parotid gland.
  • OBJECTIVE: Salivary tumors can manifest as abnormalities of the gland itself and/or changes in salivary flow.
  • The aim of the present study was to evaluate effects of benign parotid tumors on unstimulated saliva secretion from the affected gland.
  • METHODS: Unstimulated parotid saliva was collected bilaterally using the swab method in patients with unilateral pleomorphic adenoma (n=14) or Warthin's tumor (n=6).
  • Pre-weighted cotton rolls were placed at the opening of each parotid duct for 15min.
  • RESULTS: The range of salivary flow was similar to that found in studies on unstimulated parotid saliva.
  • No difference was found between the involved and non-involved side when the patients with pleomorphic adenoma or Warthin's tumor were separately analyzed.
  • CONCLUSION: The present results suggest that the most common benign parotid tumors do not alter unstimulated salivary flow from the affected gland.
  • [MeSH-major] Adenolymphoma / secretion. Adenoma, Pleomorphic / secretion. Parotid Gland / secretion. Parotid Neoplasms / secretion. Saliva / secretion

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  • (PMID = 19249167.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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96. Scheipers U, Siebers S, Gottwald F, Ashfaq M, Bozzato A, Zenk J, Iro H, Ermert H: Sonohistology for the computerized differentiation of parotid gland tumors. Ultrasound Med Biol; 2005 Oct;31(10):1287-96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonohistology for the computerized differentiation of parotid gland tumors.
  • A system for the computerized differentiation of parotid gland tumors is proposed.
  • The parotid gland is the largest of the salivary glands.
  • The results of the classification are presented as a numerical score indicating the probability of a certain tumor or alteration for each parotid gland.
  • The score can be presented to the physician during examination of the patient to improve the differentiation between various types of parotid gland tumors.
  • The receiver operating characteristic curve area is A(ROC) = 0.95 +/- 0.07 when using fourfold cross-validation over cases and differentiating between various benign parotid gland tumors and monomorphic adenoma.
  • [MeSH-major] Adenoma / ultrasonography. Cysts / ultrasonography. Image Interpretation, Computer-Assisted. Parotid Neoplasms / ultrasonography
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / surgery. Adenoma, Pleomorphic / ultrasonography. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Fuzzy Logic. Humans. Lymph Nodes / pathology. Lymph Nodes / ultrasonography. Male. Middle Aged. Parotid Diseases / pathology. Parotid Diseases / ultrasonography. Parotid Gland / pathology. Parotid Gland / surgery. Parotid Gland / ultrasonography. Probability. ROC Curve. Sensitivity and Specificity

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  • (PMID = 16223631.001).
  • [ISSN] 0301-5629
  • [Journal-full-title] Ultrasound in medicine & biology
  • [ISO-abbreviation] Ultrasound Med Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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97. Tamiolakis D, Chimona TS, Georgiou G, Proimos E, Nikolaidou S, Perogamvrakis G, Papadakis CE: Accessory parotid gland carcinoma ex pleomorphic adenoma. Case study diagnosed by fine needle aspiration. Stomatologija; 2009;11(1):37-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accessory parotid gland carcinoma ex pleomorphic adenoma. Case study diagnosed by fine needle aspiration.
  • OBJECTIVE: The accessory parotid gland is salivary tissue separated from the main parotid gland and lying on masseter muscle.
  • The accessory parotid gland exists in 21-61% of individuals.
  • However, the appearance of an accessory parotid tumor is rare, with a reported frequency of 1-7.7% of all parotid gland tumors.
  • Carcinoma ex pleomorphic adenoma arises from a pre-existing benign mixed tumor.
  • Reports of Fine Needle Aspiration Cytological (FNAC) diagnosis of malignant mixed tumor are uncommon and have been limited to cases arising in the parotid.
  • We report a case of carcinoma ex pleomorphic adenoma of the accessory lobe of the parotid, and address the cytopathology features and pitfalls of this condition.
  • FNA was performed and the smears demonstrated features indicative of pleomorphic adenoma admixed with findings indicative of a poorly differentiated carcinoma.
  • CONCLUSION: FNAC can accurately diagnose carcinoma ex pleomorphic adenoma when strongly fixed requirements are implemented.

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  • (PMID = 19423970.001).
  • [ISSN] 1392-8589
  • [Journal-full-title] Stomatologija
  • [ISO-abbreviation] Stomatologija
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Lithuania
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98. Nowak K: [Carcinosarcoma arising from a preexisting pleomorphic adenoma--true malignant mixed tumor of the parotid gland]. Otolaryngol Pol; 2007;61(6):1024-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinosarcoma arising from a preexisting pleomorphic adenoma--true malignant mixed tumor of the parotid gland].
  • Carcinosarcoma (true malignant mixed tumor) is rare in salivary gland neoplasms.
  • Even rarer is a carcinosarcoma arising from a preexisting pleomorphic adenoma.
  • Computed tomography and USG-examination revealed a mass originating from left parotid gland.
  • Clinical and histologic date revealed it had developed from a preexisting pleomorphic adenoma.
  • This tumor seemed to consist of two histogenetically different populations of cells.
  • We also review the literature and dicuss the histogenetic origin of the carcinosarcoma of salivary gland.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinosarcoma / pathology. Mixed Tumor, Malignant / pathology. Parotid Neoplasms / pathology

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  • (PMID = 18546958.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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99. Helmstaedter V, Beutner D, Drebber U, Huttenbrink KB, Streppel M: [Multiple primary pleomorphic adenomas of the unilateral parotid gland]. Laryngorhinootologie; 2007 Jun;86(6):448-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple primary pleomorphic adenomas of the unilateral parotid gland].
  • [Transliterated title] Das unilaterale, primär multilokuläre pleomorphe Adenom der Ohrspeicheldrüse.
  • BACKGROUND: Classical lateral parotidectomy is the standard surgical procedure for the management of lateral lobe parotid pleomorphic adenomas in most clinical centres.
  • CASE: We report on a 20-year-old patient with multiple primary pleomorphic adenomas in the unilateral parotid gland, which preoperatively presented as a solitary tumour node.
  • CONCLUSION: Considering this case we focus on the distinctive surgical procedures for the management of parotid pleomorphic adenomas.
  • We work out, why lateral or even total parotidectomy are justified in the treatment of solitary palpable tumours and why we account lateral parotidectomy as the standard surgical procedure for the management of lateral lobe parotid pleomorphic adenomas.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Dissection. Humans. Magnetic Resonance Imaging. Male. Parotid Gland / pathology. Parotid Gland / surgery

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  • (PMID = 17219338.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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100. Manganaris A, Patakiouta F, Kiziridou A, Manganaris T: Concurrent primary Hodgkin's lymphoma and recurrent pleomorphic adenoma of the ipsilateral parotid gland: report of a rare case. Eur Arch Otorhinolaryngol; 2007 Jan;264(1):71-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Concurrent primary Hodgkin's lymphoma and recurrent pleomorphic adenoma of the ipsilateral parotid gland: report of a rare case.
  • The synchronous occurrence of two histologically different and morphologically distinct tumours in a single parotid gland is an exceptionally rare and probably coincidental event.
  • We have recently experienced such a case initially suspected of being a recurrent pleomorphic adenoma.
  • Postoperative histopathological examination diagnosed the presence of a pleomorphic adenoma with a concurrent primary parotid gland Hodgkin's lymphoma arising from an intraglandular lymph node.
  • [MeSH-major] Adenoma, Pleomorphic / complications. Adenoma, Pleomorphic / pathology. Hodgkin Disease / complications. Hodgkin Disease / pathology. Parotid Neoplasms / complications. Parotid Neoplasms / pathology

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  • (PMID = 16896749.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 26
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