[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 1101
1. Del Rio P, Cataldo S, Sommaruga L, Arcuri MF, Massa M, Sianesi M: Localization of pathological gland's site in primary hyperparathyroidism: ten years experience with MIBI scintigraphy. G Chir; 2008 Apr;29(4):186-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Localization of pathological gland's site in primary hyperparathyroidism: ten years experience with MIBI scintigraphy.
  • BACKGROUND: Primary hyperparathyroidism (PHPT) is characterised by pathological hyperfunctioning of one or more of the parathyroid glands leading to excessive parathyroid hormone (PTH) secretion.
  • In 58 patients we proceeded with the removal of a single adenoma, in 19 cases with the removal of two out of the four glands, and in seven cases with the removal of three out of the four glands, the single formations removed not showing clearly-defined macroscopic characteristics; in two of the seven patients in whom three of the four glands were removed, the preoperative diagnostic examinations had not shown any evidence of gland pathology.
  • We consider CT, MRI and SPECT techniques to be indicated only in cases of relapse of PHPT, possibly associated with ectopic localisation of the parathyroid gland not identified in the course of previous surgical procedures.
  • [MeSH-major] Hyperparathyroidism, Primary / radionuclide imaging. Parathyroid Glands / radionuclide imaging. Radiopharmaceuticals. Technetium Tc 99m Sestamibi

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • Genetic Alliance. consumer health - TEN.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18419988.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


2. Berri RN, Lloyd LR: Detection of parathyroid adenoma in patients with primary hyperparathyroidism: the use of office-based ultrasound in preoperative localization. Am J Surg; 2006 Mar;191(3):311-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of parathyroid adenoma in patients with primary hyperparathyroidism: the use of office-based ultrasound in preoperative localization.
  • BACKGROUND: The purpose of this investigation is to show that preoperative localization of the parathyroid gland using office-based ultrasound (US) and Tc-99m sestamibi scan is superior to all other approaches in detecting a parathyroid adenoma.
  • METHODS: We performed a retrospective analysis of 43 patients who underwent parathyroidectomy for primary hyperparathyroidism.
  • RESULTS: In 42 of 43 patients, office-based US performed by a surgeon and sestamibi scintigraphy successfully detected the location of a parathyroid abnormality (42/43 cases, sensitivity = 98%, P < .05 =.0001).
  • Office-based US localized the abnormal gland to the specific side (right/left) in 36 of 43 cases (84%).
  • US localized the abnormal gland to the specific quadrant (34/43 cases [79%] sensitivity versus 23/43 cases [53%] sensitivity using sestamibi scan alone to localize to the specific quadrant, P = .03).
  • CONCLUSION: It is clear that the combined modalities of office-based US and sestamibi scintigraphy in preoperative localization have a high success rate and should be considered in parathyroid surgery.
  • [MeSH-major] Adenoma / ultrasonography. Hyperparathyroidism, Primary / ultrasonography. Parathyroid Neoplasms / ultrasonography

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16490537.001).
  • [ISSN] 0002-9610
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


3. Aspinall SR, Boase S, Malycha P: Long-term symptom relief from primary hyperparathyroidism following minimally invasive parathyroidectomy. World J Surg; 2010 Sep;34(9):2223-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term symptom relief from primary hyperparathyroidism following minimally invasive parathyroidectomy.
  • BACKGROUND: The affect of the surgical approach for primary hyperparathyroidism (1HPT) on long-term symptom relief has not been studied.
  • METHODS: In this case-control study, patients with 1HPT who had followed a protocol to assess symptoms before and after parathyroid surgery between 1999 and 2008 were contacted by letter and had blood taken to assess calcium, ionized calcium, and parathyroid hormone (PTH).
  • RESULTS: Two hundred and forty-six patients underwent parathyroid surgery and 142 responded to our correspondence, of which 64 underwent MIP and 78 BNE.
  • [MeSH-major] Hyperparathyroidism / surgery. Parathyroidectomy / methods
  • [MeSH-minor] Adenoma / blood. Case-Control Studies. Female. Humans. Minimally Invasive Surgical Procedures. Neck / surgery. Parathyroid Hormone / blood. Treatment Outcome

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] World J Surg. 2002 Aug;26(8):942-9 [12016473.001]
  • [Cites] ANZ J Surg. 2002 Feb;72(2):147-51 [12074068.001]
  • [Cites] World J Surg. 1998 Jun;22(6):513-8; discussion 518-9 [9597921.001]
  • [Cites] World J Surg. 2003 Mar;27(3):339-42 [12607063.001]
  • [Cites] Arch Surg. 2000 Feb;135(2):142-7 [10668870.001]
  • [Cites] ANZ J Surg. 2007 Sep;77(9):774-7 [17685957.001]
  • [Cites] Surgery. 2009 Dec;146(6):1006-13 [19958927.001]
  • [Cites] World J Surg. 2008 May;32(5):807-14 [18324348.001]
  • [Cites] Med Care. 1992 Jun;30(6):473-83 [1593914.001]
  • [Cites] Surgery. 2007 Feb;141(2):153-9; discussion 159-60 [17263969.001]
  • [Cites] Ann Surg. 2000 Sep;232(3):331-9 [10973383.001]
  • [Cites] Surgery. 2000 Dec;128(6):925-9;discussion 935-6 [11114625.001]
  • [Cites] World J Surg. 2009 Nov;33(11):2244-55 [19288279.001]
  • [Cites] Arch Surg. 2002 Sep;137(9):1055-9 [12215160.001]
  • [Cites] World J Surg. 2007 Nov;31(11):2075-80 [17768656.001]
  • [Cites] Ann Surg. 2007 Dec;246(6):976-80; discussion 980-1 [18043099.001]
  • [Cites] Arch Surg. 1996 Oct;131(10 ):1074-8 [8857905.001]
  • [Cites] Int J Surg. 2007 Feb;5(1):17-22 [17386909.001]
  • (PMID = 20556605.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


Advertisement
4. Barczynski M: Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring: when and why? J Postgrad Med; 2009 Oct-Dec;55(4):239-40
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive parathyroidectomy without intraoperative parathyroid hormone monitoring: when and why?
  • [MeSH-major] Hyperparathyroidism / surgery. Minimally Invasive Surgical Procedures / methods. Monitoring, Intraoperative / methods. Parathyroidectomy / methods
  • [MeSH-minor] Adenoma / complications. Adenoma / radionuclide imaging. Adenoma / surgery. Humans. Parathyroid Hormone / metabolism. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] J Postgrad Med. 2009 Oct-Dec;55(4):242-6 [20083868.001]
  • (PMID = 20083866.001).
  • [ISSN] 0972-2823
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


5. Abshirini H, Rashidi I, Saki N: Pathologic fractures: a neglected clinical feature of parathyroid adenoma. Case Rep Med; 2010;2010:357029
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathologic fractures: a neglected clinical feature of parathyroid adenoma.
  • The pattern of clinical presentation of primary hyperparathyroidism (pHPT) has changed dramatically from a severe disease to an asymptomatic condition in Western countries.
  • Imaging and nuclear medicine studies will be helpful specially in patient who candidate for surgical removal of the abnormal parathyroid gland.
  • Here, we present a 48-year-old man with multiple typical fractures in long bones and a single adenoma in his right inferior parathyroid gland. pHPT is a severe, symptomatic disease with serious complications and high morbidity in Iran.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Surgery. 1999 Jun;125(6):608-14 [10372026.001]
  • [Cites] Injury. 2002 Apr;33(3):288-91 [12084655.001]
  • [Cites] Br J Surg. 1998 Dec;85(12):1605-16 [9876061.001]
  • [Cites] Med Sci Monit. 2006 Feb;12(2):CR86-9 [16449953.001]
  • [Cites] Arch Surg. 2006 Sep;141(9):885-9; discussion 889-91 [16983032.001]
  • [Cites] Gac Med Mex. 2008 Mar-Apr;144(2):155-60 [18590035.001]
  • [Cites] AJR Am J Roentgenol. 2008 Sep;191(3):908-11 [18716127.001]
  • [Cites] J Palliat Med. 2010 Jan;13(1):77-8 [20050793.001]
  • [Cites] J Chin Med Assoc. 2010 Mar;73(3):177-80 [20231005.001]
  • [Cites] Clin Radiol. 2010 Apr;65(4):278-87 [20338394.001]
  • [Cites] Ann R Coll Surg Engl. 2010 Mar;92(2):W29-31 [20353632.001]
  • [Cites] World J Surg. 2010 Jun;34(6):1299-303 [20372897.001]
  • [Cites] J Clin Endocrinol Metab. 2010 Sep;95(9):4324-30 [20610600.001]
  • [Cites] World J Surg. 2009 Mar;33(3):406-11 [18763015.001]
  • [Cites] J Urol. 2009 May;181(5):2141-5 [19296981.001]
  • [Cites] Surgery. 1998 Dec;124(6):987-91; discussion 991-2 [9854573.001]
  • (PMID = 21209742.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3014855
  •  go-up   go-down


6. Eslamy HK, Ziessman HA: Parathyroid scintigraphy in patients with primary hyperparathyroidism: 99mTc sestamibi SPECT and SPECT/CT. Radiographics; 2008 Sep-Oct;28(5):1461-76
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid scintigraphy in patients with primary hyperparathyroidism: 99mTc sestamibi SPECT and SPECT/CT.
  • The clinical diagnosis of primary hyperparathyroidism is based largely on serum laboratory test results, as patients often are asymptomatic.
  • However, given that approximately 90% of cases are due to a single parathyroid adenoma, a better treatment may be the selective surgical excision of the hyperfunctioning parathyroid gland after its preoperative identification and localization at radiologic imaging.
  • In addition, knowledge of the anatomy and embryologic development of the parathyroid glands and the pathophysiology of primary hyperparathyroidism aid in the identification and localization of hyperfunctioning glands.
  • [MeSH-major] Hyperparathyroidism, Primary / diagnosis. Parathyroid Glands / radiography. Parathyroid Glands / radionuclide imaging. Subtraction Technique. Technetium Tc 99m Sestamibi. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) RSNA, 2008.
  • (PMID = 18794320.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  • [Number-of-references] 73
  •  go-up   go-down


7. Venkatesh KV, Nandini VV: Periapical radiolucency not requiring endodontic therapy: an unusual case. Indian J Dent Res; 2009 Jan-Mar;20(1):126-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The article is a case report of an unusual manifestation of primary hyperparathyroidism seen in the mandible.
  • Primary hyperparathyroidism is a rare disorder that can present its first symptoms in the jaws.
  • [MeSH-major] Adenoma / radiography. Hyperparathyroidism, Primary / radiography. Mandibular Diseases / radiography. Parathyroid Neoplasms / radiography. Periapical Diseases / radiography
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Radicular Cyst / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19336875.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


8. Kodama H, Iihara M, Okamoto T, Obara T: Water-clear cell parathyroid adenoma causing primary hyperparathyroidism in a patient with neurofibromatosis type 1: report of a case. Surg Today; 2007;37(10):884-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Water-clear cell parathyroid adenoma causing primary hyperparathyroidism in a patient with neurofibromatosis type 1: report of a case.
  • Water-clear cell parathyroid adenoma is an exceedingly rare tumor, composed exclusively of tumor cells with abundant foamy cytoplasm.
  • A combination of hyperparathyroidism and neurofibromatosis type 1 (NF1) is also a rare phenomenon.
  • We report an 18-year-old woman with primary hyperparathyroidism caused by water-clear cell parathyroid adenoma in association with NF1.
  • She had renal stones, hypercalcemia, and an elevated plasma level of intact parathyroid hormone.
  • A surgical exploration revealed the palpable mass to be a parathyroid tumor.
  • The pathological features were consistent with water-clear parathyroid adenoma.
  • This is the first reported case of water-clear cell parathyroid adenoma associated with NF1.
  • [MeSH-major] Hyperparathyroidism, Primary / etiology. Neurofibromatosis 1 / physiopathology. Parathyroid Neoplasms / complications


9. Vierimaa O, Villablanca A, Alimov A, Georgitsi M, Raitila A, Vahteristo P, Larsson C, Ruokonen A, Eloranta E, Ebeling TM, Ignatius J, Aaltonen LA, Leisti J, Salmela PI: Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition. J Endocrinol Invest; 2009 Jun;32(6):512-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition.
  • OBJECTIVE: Primary hyperparathyroidism (PHPT), a common endocrine condition, is usually caused by sporadically occurring parathyroid adenoma.
  • A subset of patients carry germline mutations in genes such as MEN1 (multiple endocrine neoplasia type 1), HRPT2 (hyperparathyroidism 2), and CASR (calcium-sensing receptor) predisposing to syndromic forms of PHPT or familial isolated hyperparathyroidism (FIHP).
  • [MeSH-major] Hyperparathyroidism, Primary / genetics. Parathyroid Neoplasms / genetics

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cell. 1993 Dec 31;75(7):1297-303 [7916660.001]
  • [Cites] Endocr Relat Cancer. 2007 Sep;14(3):901-6 [17914118.001]
  • [Cites] Nat Genet. 2002 Dec;32(4):676-80 [12434154.001]
  • [Cites] Surgery. 1999 Dec;126(6):1097-103; discussion 1103-4 [10598193.001]
  • [Cites] J Clin Endocrinol Metab. 1996 Dec;81(12):4204-11 [8954016.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Dec;86(12):5658-71 [11739416.001]
  • [Cites] Nature. 1993 Jun 3;363(6428):458-60 [8099202.001]
  • [Cites] J Clin Endocrinol Metab. 1998 Aug;83(8):2627-30 [9709922.001]
  • [Cites] J Clin Endocrinol Metab. 2007 May;92(5):1948-51 [17299066.001]
  • [Cites] J Clin Endocrinol Metab. 2000 Jan;85(1):165-7 [10634381.001]
  • [Cites] J Med Genet. 2006 Mar;43(3):e12 [16525030.001]
  • [Cites] Am J Hum Genet. 1998 Nov;63(5):1544-9 [9792884.001]
  • [Cites] Science. 1997 Apr 18;276(5311):404-7 [9103196.001]
  • [Cites] J Med Genet. 2001 Mar;38(3):185-9 [11303512.001]
  • [Cites] Nat Genet. 1997 Aug;16(4):375-8 [9241276.001]
  • [Cites] Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15558-63 [17030811.001]
  • [Cites] J Med Genet. 2004 Mar;41(3):155-60 [14985373.001]
  • [Cites] J Clin Invest. 1997 Apr 15;99(8):1917-25 [9109436.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Dec;87(12):5353-61 [12466320.001]
  • [Cites] Cancer Res. 2000 Oct 1;60(19):5553-7 [11034102.001]
  • [Cites] J Med Genet. 2004 Mar;41(3):e32 [14985403.001]
  • [Cites] Br J Surg. 2003 Dec;90(12):1599-603 [14648742.001]
  • [Cites] J Clin Endocrinol Metab. 2000 May;85(5):2042-7 [10843194.001]
  • [Cites] J Med Genet. 2003 Sep;40(9):657-63 [12960210.001]
  • [Cites] Science. 2006 May 26;312(5777):1228-30 [16728643.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jul;89(7):3392-6 [15240620.001]
  • [Cites] Eur J Clin Invest. 2000 Jun;30(6):487-92 [10849016.001]
  • [Cites] Eur J Clin Invest. 2000 Apr;30(4):325-9 [10759881.001]
  • [Cites] Clin Endocrinol (Oxf). 2005 Feb;62(2):169-75 [15670192.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Nov;89(11):5583-91 [15531515.001]
  • [Cites] N Engl J Med. 2003 Oct 30;349(18):1722-9 [14585940.001]
  • [Cites] Br J Cancer. 2007 Jan 29;96(2):352-6 [17242703.001]
  • [Cites] Clin Endocrinol (Oxf). 2006 Feb;64(2):146-52 [16430712.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Aug;92(8):3321-5 [17519308.001]
  • [Cites] Medicine (Baltimore). 2002 Jan;81(1):1-26 [11807402.001]
  • [Cites] Eur J Endocrinol. 2002 Sep;147(3):313-22 [12213668.001]
  • [Cites] J Clin Endocrinol Metab. 1998 Aug;83(8):2960-3 [9709976.001]
  • [Cites] J Med Genet. 2005 Jan;42(1):69-74 [15635078.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Jan;89(1):96-102 [14715834.001]
  • [Cites] J Clin Endocrinol Metab. 2007 Sep;92(9):3389-95 [17623761.001]
  • [Cites] J Intern Med. 1998 Jun;243(6):471-6 [9681845.001]
  • (PMID = 19474519.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CASR protein, human; 0 / CDC73 protein, human; 0 / CDKN1B protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / MEN1 protein, human; 0 / Proto-Oncogene Proteins; 0 / Receptors, Calcium-Sensing; 0 / Tumor Suppressor Proteins; 0 / aryl hydrocarbon receptor-interacting protein; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; 9007-49-2 / DNA
  •  go-up   go-down


10. Testini M, Gurrado A, Lissidini G, Piccinni G, Greco L, Basile F, Biondi A: Parathyroid hormone-related peptide and primary hyperparathyroidism. Front Biosci (Schol Ed); 2010;2:299-312
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid hormone-related peptide and primary hyperparathyroidism.
  • The parathyroid hormone-related peptide (PTHrP) has been shown to be the major pathogenic factor to humoral hypercalcemia of malignancy (HHM).
  • PTHrP release from parathyroid cells into the extracellular space has been demonstrated to depend on the extracellular calcium concentration.
  • The hormone binds to PTH type 1 Receptor (PTH1R) with a high affinity, as well as parathyroid hormone (PTH).
  • Generally, diagnosis of primary hyperparathyroidism (PHPT) is based on hypercalcaemia and elevated levels of PTH.
  • The advent of intact-PTH immunoradiometric assay allowed us to distinguish PHPT from non-parathyroid-dependent hypercalcaemia, but the presentation of normal PTH level and hypercalcaemia due to a parathyroid adenoma is possible.
  • The aim of the study is to identify the relationship between the production of PTHrP without malignancy and the diagnosis of PHPT by a systematic review.
  • [MeSH-major] Hypercalcemia / metabolism. Hyperparathyroidism, Primary / diagnosis. Hyperparathyroidism, Primary / metabolism. Parathyroid Hormone-Related Protein / metabolism. Receptor, Parathyroid Hormone, Type 1 / metabolism. Second Messenger Systems / physiology

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20036948.001).
  • [ISSN] 1945-0524
  • [Journal-full-title] Frontiers in bioscience (Scholar edition)
  • [ISO-abbreviation] Front Biosci (Schol Ed)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein; 0 / Receptor, Parathyroid Hormone, Type 1; SY7Q814VUP / Calcium
  • [Number-of-references] 195
  •  go-up   go-down


11. Urquhart AC, Wiley C: Arterial and venous parathyroid hormone levels in minimally invasive surgery. Arch Otolaryngol Head Neck Surg; 2005 Feb;131(2):137-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Arterial and venous parathyroid hormone levels in minimally invasive surgery.
  • OBJECTIVE: To establish if venous and arterial parathyroid hormone (PTH) levels are similar during minimal access parathyroid surgery.
  • PATIENTS: All patients who underwent minimally invasive parathyroid surgery over a 10-month period.
  • All patients underwent a preoperative technetium Tc 99m sestamibi scan, with 11 localizing to the site of a probable adenoma.
  • Of 13 patients undergoing both arterial and venous sampling, mean baseline venous PTH level was 221 pg/mL and 37 pg/mL at 10 minutes after excision of suspected adenoma (83% decline).
  • CONCLUSIONS: Intraoperative PTH levels during minimal access parathyroid surgery are similar for venous and arterial samples.
  • [MeSH-major] Blood Specimen Collection / methods. Parathyroid Hormone / blood. Parathyroidectomy

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15723945.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


12. Portela-Gomes GM, Grimelius L, Stridsberg M: Secretogranin III in human neuroendocrine tumours: a comparative immunohistochemical study with chromogranins A and B and secretogranin II. Regul Pept; 2010 Nov 30;165(1):30-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The expression of SgIII agreed well with that of CgA, CgB and SgII, with exceptions of phaeochromocytomas, where more CgB and SgII immunoreactive cells were observed and parathyroid adenomas, which were only stained by CgA.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20550951.001).
  • [ISSN] 1873-1686
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Chromogranin B; 0 / Chromogranins; 0 / Secretogranin II; 0 / secretogranin III
  •  go-up   go-down


13. Yang C, Wang SL, Cai CP: [A case report of ectopic parathyroid adenoma on piriform fossa]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Aug;45(8):694-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case report of ectopic parathyroid adenoma on piriform fossa].
  • [MeSH-major] Adenoma / diagnosis. Esophageal Neoplasms / diagnosis. Parathyroid Neoplasms / diagnosis

  • MedlinePlus Health Information. consumer health - Esophageal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21055254.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  •  go-up   go-down


14. Kollars J, Zarroug AE, van Heerden J, Lteif A, Stavlo P, Suarez L, Moir C, Ishitani M, Rodeberg D: Primary hyperparathyroidism in pediatric patients. Pediatrics; 2005 Apr;115(4):974-80
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism in pediatric patients.
  • OBJECTIVE: Primary hyperparathyroidism (HPT) is unusual in children.
  • METHODS: The retrospective review of patients <19 years old who underwent parathyroid resection for primary HPT from 1970 to 2000 was performed at a single institution..
  • Eighty-five percent had an elevated parathyroid hormone (PTH) level, and 15% had an inappropriately normal PTH level during hypercalcemia.
  • Thirty-four patients (65%) had a single adenoma; hyperplasia was identified in 16 patients (27%), and of these cases, 57% occurred in patients diagnosed with MEN-I.
  • No parathyroid abnormalities were identified during exploration in 4 (8%) children.
  • CONCLUSION: The diagnosis of primary HPT in pediatric patients is frequently delayed, is commonly symptomatic, and has significant morbidity.
  • Parathyroid resection is effective at restoring normal serum calcium, has few complications, and is the treatment of choice for children with primary hyperparathyroidism.
  • [MeSH-major] Hyperparathyroidism / complications. Hyperparathyroidism / diagnosis
  • [MeSH-minor] Adenoma / complications. Adolescent. Bone Diseases, Metabolic / etiology. Child. Child, Preschool. Female. Humans. Hypercalcemia / etiology. Hypocalcemia / etiology. Kidney Calculi / etiology. Male. Multiple Endocrine Neoplasia / complications. Nephrocalcinosis / etiology. Parathyroid Hormone / blood. Parathyroid Neoplasms / complications. Parathyroidectomy. Postoperative Complications. Retrospective Studies. Sex Distribution

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Pediatrics. 2005 Apr;115(4):1073 [15805388.001]
  • (PMID = 15805373.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


15. Imachi H, Murao K, Kontani K, Yokomise H, Miyai Y, Yamamoto Y, Kushida Y, Haba R, Ishida T: Ectopic mediastinal parathyroid adenoma: a cause of acute pancreatitis. Endocrine; 2009 Oct;36(2):194-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic mediastinal parathyroid adenoma: a cause of acute pancreatitis.
  • After the episode of acute pancreatitis subsided, laboratory investigation revealed increased serum calcium (12.0 mg/dl), decreased serum phosphorus (2.7 mg/dl), and increased serum parathyroid hormone (intact) levels (131 pg/ml).
  • A computed tomography (CT) scan of the neck did not reveal any mass lesions in the parathyroid gland.
  • However, (99m)Tc sestamibi scintigraphy revealed that there was one functioning parathyroid gland in the upper mediastinum.
  • Combined (99m)Tc sestamibi scintigraphy and CT scan confirmed the diagnosis of primary hyperparathyroidism in the mediastinum.
  • Microscopic examination revealed the presence of a parathyroid adenoma (1.3 x 0.4 cm(2)) adjacent to the atrophic parathyroid gland in right thymus gland.
  • We report the case of a patient diagnosed with primary hyperparathyroidism due to an ectopic mediastinal parathyroid adenoma.
  • An ectopic mediastinal parathyroid adenoma may manifest as an episode of acute pancreatitis.
  • Preoperative investigation to determine the exact location of an adenoma should include two types of imaging studies, preferably (99m)Tc sestamibi scintigraphy and CT of the neck and chest.
  • [MeSH-major] Adenoma / complications. Choristoma. Mediastinal Diseases / complications. Pancreatitis / etiology. Parathyroid Glands. Parathyroid Neoplasms / complications
  • [MeSH-minor] Adult. Humans. Hyperparathyroidism, Primary / diagnosis. Hyperparathyroidism, Primary / etiology. Male

  • Genetic Alliance. consumer health - Pancreatitis.
  • MedlinePlus Health Information. consumer health - Pancreatitis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Am Coll Surg. 2002 Sep;195(3):364-71 [12229945.001]
  • [Cites] ANZ J Surg. 2006 Aug;76(8):740-4 [16916398.001]
  • [Cites] Indian J Gastroenterol. 2003 Nov-Dec;22(6):224-5 [15030035.001]
  • [Cites] J Pediatr Endocrinol Metab. 2008 Dec;21(12):1191-4 [19189694.001]
  • [Cites] J Nucl Med. 2008 Nov;49(11):1813-8 [18927330.001]
  • [Cites] Alcohol. 2008 Nov;42(7):565-73 [18774672.001]
  • [Cites] Semin Nucl Med. 2005 Oct;35(4):266-76 [16150247.001]
  • [Cites] J Gastroenterol Hepatol. 2008 Jun;23(6):959-64 [17683498.001]
  • [Cites] World J Surg. 2005 Apr;29(4):491-4 [15770373.001]
  • [Cites] Rev Esp Enferm Dig. 2009 Jan;101(1):65-9 [19335036.001]
  • [Cites] Radiographics. 1999 May-Jun;19(3):601-14; discussion 615-6 [10336191.001]
  • [Cites] Surgery. 2004 Dec;136(6):1199-204 [15657576.001]
  • [Cites] N Engl J Med. 2004 Apr 22;350(17):1746-51 [15103001.001]
  • [Cites] Am J Surg. 2008 Jun;195(6):799-802 [18436184.001]
  • [Cites] Aust N Z J Surg. 1996 Feb;66(2):85-7 [8602820.001]
  • [Cites] Aust N Z J Surg. 1998 Feb;68(2):117-9 [9494002.001]
  • [Cites] J Clin Endocrinol Metab. 2009 Jun;94(6):2115-8 [19318456.001]
  • [Cites] J Gastroenterol Hepatol. 2008 Sep;23(9):1339-48 [18853993.001]
  • [Cites] Nucl Med Commun. 2005 Jul;26(7):633-8 [15942484.001]
  • (PMID = 19598003.001).
  • [ISSN] 1559-0100
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


16. Charrié A, Chikh K, Peix JL, Berger N, Decaussin M, Veber S, Bienvenu J, Lifante JC, Fabien N: Calcium-sensing receptor autoantibodies in primary hyperparathyroidism. Clin Chim Acta; 2009 Aug;406(1-2):94-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calcium-sensing receptor autoantibodies in primary hyperparathyroidism.
  • BACKGROUND: Mutations in the extracellular calcium-sensing receptor (CaSR) gene are known to be implicated in some cases of primary hyperparathyroidism.
  • However, not all patients display such mutations and so the mechanisms of primary hyperparathyroidism are still largely unknown.
  • The aim of our study was to investigate the presence of CaSR autoantibodies in a large cohort of patients with primary hyperparathyroidism.
  • METHODS: Seventy-five patients were tested for the presence of anti-parathyroid antibodies using an immunoblotting assay with the recombinant extracellular domain of the human CaSR and an immunofluorescence technique with parathyroid adenoma.
  • There was no statistically significant difference in the decrease of parathyroid hormone (PTH) level after surgery between patients with or without autoantibodies.
  • Histological examination of parathyroid tissue did not show greater lymphocytic infiltration in patients with autoantibodies than in those without.
  • CONCLUSIONS: This study confirmed that some patients with primary hyperparathyroidism displayed CaSR autoantibodies.
  • The pathophysiological role of these autoantibodies in hyperparathyroidism needs to be further elucidated.
  • [MeSH-major] Autoantibodies / immunology. Hyperparathyroidism, Primary / immunology. Receptors, Calcium-Sensing / immunology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Autoimmune Diseases / blood. Autoimmune Diseases / immunology. Autoimmune Diseases / pathology. Autoimmune Diseases / surgery. Calcium / blood. Cohort Studies. Female. Humans. Male. Middle Aged. Parathyroid Hormone / blood

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19520070.001).
  • [ISSN] 1873-3492
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Parathyroid Hormone; 0 / Receptors, Calcium-Sensing; SY7Q814VUP / Calcium
  •  go-up   go-down


17. Varma D, Nigam S, Singhal N, Mandal AK, Kakkar A: A report of two cases of Hashimoto's thyroiditis and synchronous parathyroid adenoma. Indian J Pathol Microbiol; 2006 Oct;49(4):635-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A report of two cases of Hashimoto's thyroiditis and synchronous parathyroid adenoma.
  • [MeSH-major] Hashimoto Disease / complications. Parathyroid Neoplasms / complications

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17183886.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
  •  go-up   go-down


18. Somashekhar SP, Gupta P, Ballal S, Parameshwaran, Zaveri SS, Venkatachala, Udupa KV: Minimally invasive radioguided surgery for parathyroid adenomas (MIRP). Natl Med J India; 2007 Jan-Feb;20(1):13-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive radioguided surgery for parathyroid adenomas (MIRP).
  • BACKGROUND: Parathyroid adenoma is the most common cause of primary hyperparathyroidism.
  • Conventional surgical management includes bilateral neck exploration with removal of the adenoma(s) and biopsy of one of the other glands with visualization of all glands.
  • Radioguided excision of parathyroid adenoma is a widely accepted technique which provides accurate localization and complete excision of the lesion with low morbidity.
  • METHODS: We performed radioguided excision of parathyroid adenomas in 15 patients.
  • All of them had preoperative localization of the adenoma using a dual tracer, dual phase 99mTc-Sestamibi scan.
  • RESULTS: The 99mTc-Sestamibi scan revealed an increased uptake by the adenoma in all patients and complete excision was possible in all the patients.
  • Frozen section confirmed the diagnosis and the quick parathormone assay (within 15 minutes) revealed a drop in parathormone levels to < 50% after excision in all of them.
  • CONCLUSION: Minimally invasive radioguided excision of parathyroid adenomas is a simple, safe and effective technique associated with a low morbidity and can be done as a day-care procedure.
  • [MeSH-major] Hyperparathyroidism, Primary / surgery. Minimally Invasive Surgical Procedures. Parathyroid Neoplasms / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17557516.001).
  • [ISSN] 0970-258X
  • [Journal-full-title] The National medical journal of India
  • [ISO-abbreviation] Natl Med J India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


19. Salaverría Garzón I, Villaseñor Navas M, Sánchez Herrera S, Martínez Elbal L: [Tako-Tsubo syndrome (transient apical dyskinesia). An entity that can mimic a myocardial infarction]. An Med Interna; 2008 Jan;25(1):20-2
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Síndrome de Tako-Tsubo (discinesia apical transitoria). Un síndrome que simula un infarto de miocardio.
  • [MeSH-major] Myocardial Infarction / diagnosis. Postoperative Complications / diagnosis. Takotsubo Cardiomyopathy / diagnosis
  • [MeSH-minor] Adenoma / surgery. Biomarkers. Coronary Angiography. Diagnosis, Differential. Electrocardiography. Female. Humans. Middle Aged. Parathyroid Neoplasms / surgery. Parathyroidectomy. Thyroidectomy / methods

  • MedlinePlus Health Information. consumer health - After Surgery.
  • MedlinePlus Health Information. consumer health - Heart Attack.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18377190.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers
  •  go-up   go-down


20. Mazzaglia PJ, Milas M, Berber E, Siperstein A, Monchik JM: Normalization of 2-week postoperative parathyroid hormone values in patients with primary hyperparathyroidism: four-gland exploration compared to focused-approach surgery. World J Surg; 2010 Jun;34(6):1318-24
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Normalization of 2-week postoperative parathyroid hormone values in patients with primary hyperparathyroidism: four-gland exploration compared to focused-approach surgery.
  • BACKGROUND: Elevation of parathyroid hormone (PTH) levels is commonly seen in patients with primary hyperparathyroidism (PHPT) who have undergone parathyroidectomy.
  • This study evaluates differences in 2-week postoperative PTH levels in patients having focused-approach surgery versus four-gland exploration.
  • METHODS: Over 6 years, patients at Rhode Island Hospital (RIH) and the Cleveland Clinic (CCF) who had PHPT and underwent localization studies suggestive of single adenoma were analyzed.
  • At RIH patients underwent focused-approach surgery, and at CCF routine four-gland exploration was performed.
  • Preoperative PTH values were similar, measuring 143.8 +/- 104.8 pg/ml in the focused-approach group (RIH) and 157.6 +/- 150.3 pg/ml in the four-gland exploration group (CCF).
  • The total gland weight resected per patient was 942 mg at RIH versus 1,394 mg at CCF (P = 0.003).
  • The elevation was more frequent in the four-gland exploration group and correlated most strongly with greater adenoma mass.
  • [MeSH-major] Hyperparathyroidism, Primary / blood. Hyperparathyroidism, Primary / surgery. Parathyroid Hormone / blood. Parathyroidectomy

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • Genetic Alliance. consumer health - Hyperparathyroidism 2.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Surgery. 1986 Dec;100(6):1021-31 [3787459.001]
  • [Cites] Arch Pathol Lab Med. 2008 Aug;132(8):1251-62 [18684024.001]
  • [Cites] Surgery. 1987 Dec;102(6):898-902 [3686352.001]
  • [Cites] Am Surg. 2004 Feb;70(2):114-9; discussion 119-20 [15011912.001]
  • [Cites] World J Surg. 2003 Feb;27(2):212-5 [12616439.001]
  • [Cites] World J Surg. 1998 Jun;22(6):513-8; discussion 518-9 [9597921.001]
  • [Cites] Surgery. 2005 Dec;138(6):1018-25; discussion 1025-6 [16360386.001]
  • [Cites] Ann Surg. 2002 Nov;236(5):543-51 [12409657.001]
  • [Cites] Surgery. 2007 Jun;141(6):777-83 [17560254.001]
  • [Cites] Arch Surg. 2000 Feb;135(2):142-7 [10668870.001]
  • [Cites] Surgery. 2005 Apr;137(4):419-25 [15800489.001]
  • [Cites] Ann Intern Med. 1997 Mar 15;126(6):433-40 [9072928.001]
  • [Cites] Ann Surg. 2008 Sep;248(3):420-8 [18791362.001]
  • [Cites] Surgery. 2002 Dec;132(6):1086-92; discussion 1092-3 [12490859.001]
  • [Cites] Arch Surg. 2005 May;140(5):472-8; discussion 478-9 [15897443.001]
  • [Cites] Surgery. 2004 Oct;136(4):872-80 [15467674.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2002 Mar;128(3):275-9 [11886343.001]
  • [Cites] Surgery. 1996 Jun;119(6):624-33 [8650602.001]
  • [Cites] World J Surg. 1991 Nov-Dec;15(6):688-92 [1767534.001]
  • [Cites] Am J Surg. 1991 Oct;162(4):299-302 [1683177.001]
  • [Cites] Ann Surg. 2004 May;239(5):704-8; discussion 708-11 [15082975.001]
  • [Cites] Kidney Int. 2000 Oct;58(4):1440-9 [11012879.001]
  • [Cites] J Am Coll Surg. 2004 Dec;199(6):849-53; discussion 853-5 [15555964.001]
  • [Cites] Arch Surg. 1992 Oct;127(10):1157-6; discussion 1161-3 [1417479.001]
  • [Cites] Ann Surg. 2002 May;235(5):665-70; discussion 670-2 [11981212.001]
  • [Cites] World J Surg. 2000 Nov;24(11):1323-9 [11038201.001]
  • [Cites] Surgery. 2006 Oct;140(4):665-72; discussion 672-4 [17011915.001]
  • [Cites] Ann Surg. 1995 Sep;222(3):402-12; discussion 412-4 [7677469.001]
  • [Cites] Ann Surg. 1992 Apr;215(4):300-17 [1558410.001]
  • [Cites] Arch Surg. 2008 Mar;143(3):260-6 [18347273.001]
  • [Cites] Am J Surg. 2001 Jul;182(1):15-9 [11532408.001]
  • (PMID = 20386907.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 1406-16-2 / Vitamin D; SY7Q814VUP / Calcium
  •  go-up   go-down


21. Jorna FH, Hollema H, Hendrikse HN, Bart J, Brouwers AH, Plukker JT: P-gp and MRP1 expression in parathyroid tumors related to histology, weight and (99m)Tc-sestamibi imaging results. Exp Clin Endocrinol Diabetes; 2009 Sep;117(8):406-12
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] P-gp and MRP1 expression in parathyroid tumors related to histology, weight and (99m)Tc-sestamibi imaging results.
  • OBJECTIVE: P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) are membrane efflux pumps that may have a role in the kinetics of (99m)Tc-sestamibi (MIBI) in parathyroid tumors.
  • P-gp and MRP1 expression in parathyroid tumors was studied and related to histology, weight and pre- and intraoperative MIBI imaging results.
  • DESIGN: Patient cohort study SETTING: Tertiary referral center PATIENTS: Thirty-three patients underwent radioguided parathyroidectomy for primary or secondary hyperparathyroidism.
  • Radioactivity and weight of resected parathyroid tumors were measured.
  • After routine histology immunohistochemistry was performed using C494 monoclonal antibodies to P-gp and MRP1r1 to MRP1.
  • P-gp staining was positive in 91% (21/23) of the adenomas and in all 36 hyperplastic glands.
  • MRP1 staining was positive in 22% (5/23) of the adenomas and in 61% (22/36) of the hyperplastic glands.
  • Parathyroid weight was associated with preoperative MIBI imaging results and MIBI uptake measured during surgery.
  • CONCLUSION: P-gp and MRP1 expression did not correlate with (99m)Tc-MIBI uptake in parathyroid tumors.
  • Parathyroid weight remains the major known factor influencing (99m)Tc-MIBI uptake.
  • [MeSH-major] Adenoma / metabolism. Hyperparathyroidism, Primary / metabolism. Hyperparathyroidism, Secondary / metabolism. Multidrug Resistance-Associated Proteins / metabolism. P-Glycoprotein / metabolism. Parathyroid Glands / metabolism. Parathyroid Neoplasms / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart.New York.
  • (PMID = 19235131.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Multidrug Resistance-Associated Proteins; 0 / P-Glycoprotein; 0 / multidrug resistance-associated protein 1; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


22. Carling T, Udelsman R: Focused approach to parathyroidectomy. World J Surg; 2008 Jul;32(7):1512-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Minimally invasive parathyroidectomy is performed after preoperative parathyroid localization-usually with high-quality sestamibi scans and/or ultrasonography-often under cervical block anesthesia during which a limited exploration is performed.
  • The rapid intraoperative parathyroid hormone assay is then employed to confirm an adequate resection and cure of primary hyperparathyroidism.
  • [MeSH-major] Adenoma / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods
  • [MeSH-minor] Humans. Minimally Invasive Surgical Procedures. Neck. Nerve Block. Parathyroid Hormone / blood. Preoperative Care

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Surgery. 2005 Dec;138(6):1066-71; discussion 1071 [16360392.001]
  • [Cites] Ann Surg. 2003 May;237(5):714-9; discussion 719-21 [12724638.001]
  • [Cites] Surgery. 2005 Dec;138(6):1121-8; discussion 1128-9 [16360399.001]
  • [Cites] Arch Surg. 2006 Apr;141(4):401-4; discussion 404 [16618900.001]
  • [Cites] Clin Radiol. 2001 Jul;56(7):556-9 [11446753.001]
  • [Cites] Ann Surg. 2002 Nov;236(5):543-51 [12409657.001]
  • [Cites] J Nucl Med. 2007 Jul;48(7):1084-9 [17574983.001]
  • [Cites] Surgery. 1996 Dec;120(6):1039-45 [8957492.001]
  • [Cites] Surgery. 2006 Dec;140(6):907-13; discussion 913 [17188137.001]
  • [Cites] Hum Pathol. 1975 Nov;6(6):645-8 [1102424.001]
  • [Cites] Surgery. 2001 Dec;130(6):1011-8 [11742331.001]
  • [Cites] Clin Endocrinol (Oxf). 2006 Jul;65(1):106-13 [16817828.001]
  • [Cites] Ann Surg. 1982 Mar;195(3):245-52 [7059236.001]
  • [Cites] Ann Surg. 2005 Sep;242(3):375-80; discussion 380-3 [16135923.001]
  • [Cites] Clin Nucl Med. 1998 May;23 (5):291-7 [9596153.001]
  • [Cites] Nucl Med Commun. 2006 Dec;27(12):977-87 [17088684.001]
  • [Cites] Ann Surg. 2000 Sep;232(3):331-9 [10973383.001]
  • [Cites] Ann Surg. 1996 Sep;224(3):308-20; discussion 320-1 [8813259.001]
  • [Cites] J Clin Endocrinol Metab. 1996 Jan;81(1):346-52 [8550776.001]
  • [Cites] Thyroid. 2002 Jan;12 (1):53-61 [11838731.001]
  • [Cites] J Endocrinol Invest. 1992;15(9 Suppl 6):149-56 [1300333.001]
  • [Cites] Nucl Med Commun. 1989 Nov;10 (11):791-4 [2532313.001]
  • [Cites] J Am Coll Surg. 1998 Mar;186(3):293-305 [9510260.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Dec;87(12):5353-61 [12466320.001]
  • [Cites] J Intern Med. 2005 Jan;257(1):27-37 [15606374.001]
  • [Cites] Curr Probl Surg. 1985 Nov;22(11):1-50 [4085260.001]
  • [Cites] Surgery. 2004 Dec;136(6):1138-42 [15657568.001]
  • [Cites] Am J Surg. 2007 Feb;193(2):155-9 [17236840.001]
  • [Cites] World J Surg. 2006 Jul;30(7):1234-9 [16794907.001]
  • [Cites] Curr Treat Options Oncol. 2003 Aug;4(4):319-28 [12943612.001]
  • [Cites] Ann Surg. 2006 Sep;244(3):471-9 [16926573.001]
  • [Cites] Eur J Nucl Med. 1994 Jan;21(1):17-22 [8088281.001]
  • [Cites] Ann Surg. 2002 Dec;236(6):823-32 [12454521.001]
  • [Cites] Ann Surg. 2002 May;235(5):665-70; discussion 670-2 [11981212.001]
  • [Cites] Surgery. 1999 Dec;126(6):1011-4; discussion 1014-5 [10598181.001]
  • [Cites] Ann Surg Oncol. 2006 Dec;13(12 ):1690-5 [17009140.001]
  • [Cites] J Bone Miner Res. 2002 Nov;17 Suppl 2:N117-25 [12412788.001]
  • (PMID = 18392651.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


23. Liang JH, Luo HL, Li L: [The jaw multiple tumor-like lesions as the first symptom of the parathyroid adenoma:a case report]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Dec;45(12):1048
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The jaw multiple tumor-like lesions as the first symptom of the parathyroid adenoma:a case report].
  • [MeSH-major] Jaw / pathology. Parathyroid Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21215061.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  •  go-up   go-down


24. Nilsson IL, Zedenius J, Yin L, Ekbom A: The association between primary hyperparathyroidism and malignancy: nationwide cohort analysis on cancer incidence after parathyroidectomy. Endocr Relat Cancer; 2007 Mar;14(1):135-40
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The association between primary hyperparathyroidism and malignancy: nationwide cohort analysis on cancer incidence after parathyroidectomy.
  • In order to evaluate the link between primary hyperparathyroidism (pHPT) and malignancies, cases subjected to parathyroid adenomectomy (PTX) during 1958-1997 in Sweden were identified by analyzing the National Swedish Cancer Registry.
  • This suggests a causal disassociation with the biochemical derangements caused by parathyroid adenoma, while potentially common etiological mechanisms may include genetic predisposition or acquired disability to withstand environmental influence.
  • [MeSH-major] Adenoma / epidemiology. Hyperparathyroidism, Primary / epidemiology. Neoplasms / epidemiology. Parathyroid Neoplasms / epidemiology

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - Benign Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17395982.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


25. Okuda I, Nakajima Y, Miura D, Maruno H, Kohno T, Hirata K: Diagnostic localization of ectopic parathyroid lesions: developmental consideration. Jpn J Radiol; 2010 Dec;28(10):707-13
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic localization of ectopic parathyroid lesions: developmental consideration.
  • Parathyroid glands arise from the third and fourth pharyngeal pouches.
  • Parathyroid lesions sometimes develop ectopically.
  • The aim of this article is to illustrate the knowledge of pharyngeal apparatus development to assist with diagnostic localization of ectopic parathyroid lesions.
  • We retrospectively reviewed charts of 23 patients who received a diagnosis of ectopic parathyroid lesions.
  • In most cases, parathyroid tissues were associated with structures related to the third or fourth pharyngeal pouches that traveled to regions where the ectopic lesions ultimately developed.
  • In a few cases, lesions were not associated with these pouches and might have developed from parathyroid tissue that migrated due to an anomalous pathway of parathyroid travel.
  • When patients present without entopic lesions, the presence of ectopic lesions should be evaluated based on an understanding of the developmental mechanisms of parathyroid glands and the frequency with which ectopic lesions have been found in specific locations.
  • Systematic diagnosis can minimize the frequency with which ectopic lesions are missed during clinical care and maximize their accurate localization.
  • [MeSH-major] Adenoma / diagnostic imaging. Parathyroid Neoplasms / diagnostic imaging
  • [MeSH-minor] Adult. Aged. Contrast Media. Female. Humans. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Male. Middle Aged. Parathyroid Glands / diagnostic imaging. Parathyroid Glands / pathology. Radionuclide Imaging. Radiopharmaceuticals. Retrospective Studies. Technetium Tc 99m Sestamibi. Tomography, X-Ray Computed / methods

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Radiology. 1996 Nov;201(2):456-62 [8888240.001]
  • [Cites] Arch Pathol Lab Med. 1988 Mar;112(3):304-6 [3345129.001]
  • [Cites] Am J Surg. 2006 Mar;191(3):418-23 [16490559.001]
  • [Cites] Clin Nucl Med. 1996 Jan;21(1):27-32 [8741886.001]
  • [Cites] Langenbecks Arch Surg. 2008 Jan;393(1):21-4 [17294211.001]
  • [Cites] Hormones (Athens). 2009 Apr-Jun;8(2):144-9 [19570742.001]
  • [Cites] Ann Thorac Surg. 2000 Jan;69(1):221-3 [10654517.001]
  • [Cites] AJR Am J Roentgenol. 1985 Aug;145(2):249-54 [3875220.001]
  • [Cites] Surg Today. 1999;29(8):766-8 [10483753.001]
  • [Cites] World J Surg. 2001 Apr;25(4):419-23 [11344391.001]
  • [Cites] Ann Surg. 1992 Apr;215(4):300-17 [1558410.001]
  • (PMID = 21191734.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


26. Nito T, Miyajima C, Kimura M, Sugasawa M: Parathyroid adenoma causing spontaneous cervical hematoma: a case report. Acta Otolaryngol Suppl; 2007 Dec;(559):160-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid adenoma causing spontaneous cervical hematoma: a case report.
  • A case of parathyroid adenoma causing a spontaneous cervical hematoma is reported.
  • Primary hyperparathyroidism and a parathyroid tumor on the left side of the neck had been found 2 years earlier.
  • A pathological diagnosis revealed a parathyroid adenoma with hemosiderin deposition and fibrosis.
  • Although a spontaneous cervical hematoma resulting from parathyroid tumors rarely occurs, it may lead to an airway compromise.
  • [MeSH-major] Hematoma / etiology. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / radiography
  • [MeSH-minor] Female. Fiber Optic Technology. Humans. Hypercalcemia / complications. Hypercalcemia / diagnosis. Hyperparathyroidism, Primary / complications. Laryngoscopy. Middle Aged. Neck. Parathyroidectomy. Tomography, X-Ray Computed

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18340589.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
  •  go-up   go-down


27. Pu RT, Yang J, Wasserman PG, Bhuiya T, Griffith KA, Michael CW: Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration? Diagn Cytopathol; 2006 May;34(5):330-4
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The diagnosis of an adequately sampled thyroid FNA is generally grouped into three categories: benign, malignant, and indeterminate.
  • The latter group usually includes follicular neoplasm, follicular lesion, and sometimes a more specific diagnosis such as Hurthle cell neoplasm or follicular lesion/neoplasm with Hurthle cell change.
  • Whether a FNA diagnosis of Hurthle cell lesion/neoplasm (HLN) denotes a worse clinical outcome than follicular lesion/neoplasm (FLN) remains controversial.
  • A cohort of 303 thyroid FNA cases with follow-up thyroidectomy in our institutes was identified, with the follow-up excision diagnosis compared to the FNA diagnosis in order to address this issue.
  • Of this cohort, 87 cases had an FNA diagnosis of HLN while 216 cases had a diagnosis of FLN.
  • Upon excision, the FNA diagnosis of HLN group had 14 cases of goiter/nodular hyperplasia (16%), 46 cases of adenoma (12 follicular adenoma (14%) and 34 cases of Hurthle cell adenoma (39%)), and 27 cases of carcinoma (31%, 12 papillary carcinoma and 15 Hurthle cell carcinoma).
  • The FLN group had 74 cases of goiter/nodular hyperplasia (34.3%), 8 cases of Hashimoto thyroiditis (3.7%), 73 cases of follicular adenoma (33.8%), one case of granular cell tumor, and 60 cases of carcinoma (27.8%, 46 papillary carcinoma, 12 follicular carcinoma, and 1 Hurthle cell carcinoma and 1 parathyroid carcinoma) upon excision.
  • There is no significant difference in predicting cancer between the two cytology diagnosis groups (HLN versus FLN, 31% versus 27.8%, P = 0.5771).
  • When sorting all the cases by the surgical diagnosis, while comparable for age at diagnosis, the cancer group having the higher proportion of male patients than the non-cancer group (28.7% versus 16.7%, P = 0.0259).
  • Our results suggest that an FNA diagnosis of HLN does not predict more malignancy than FLN.
  • Males and older patients with a HLN FNA diagnosis carry a higher risk of Hurthle cell carcinoma upon thyroidectomy.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Adenoma / pathology. Adenoma, Oxyphilic / pathology. Biopsy, Fine-Needle / methods. Oxyphil Cells / pathology. Thyroid Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16604553.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


28. Agrawal R, Agarwal S, Mishra A, Agarwal G, Agarwal A, Verma AK, Mishra SK, Chand G: Primary hyperparathyroidism from parathyroid microadenoma. J Am Coll Surg; 2010 Sep;211(3):436-7; author reply 437-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism from parathyroid microadenoma.
  • [MeSH-major] Adenoma / complications. Adenoma / diagnosis. Hyperparathyroidism, Primary / etiology. Parathyroid Glands / pathology. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / diagnosis. Parathyroidectomy
  • [MeSH-minor] Biomarkers / blood. Biomarkers, Tumor / blood. Calcium / blood. Diagnosis, Differential. Frozen Sections. Humans. Hyperplasia / diagnosis. Parathyroid Hormone / blood. Predictive Value of Tests

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] J Am Coll Surg. 2010 Apr;210(4):456-62 [20347738.001]
  • (PMID = 20800204.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
  •  go-up   go-down


29. Arnault V, Beaulieu A, Lifante JC, Sitges Serra A, Sebag F, Mathonnet M, Hamy A, Meurisse M, Carnaille B, Kraimps JL: Multicenter study of 19 aortopulmonary window parathyroid tumors: the challenge of embryologic origin. World J Surg; 2010 Sep;34(9):2211-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicenter study of 19 aortopulmonary window parathyroid tumors: the challenge of embryologic origin.
  • BACKGROUND: Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW).
  • The embryological origin of these abnormal parathyroid glands is controversial.
  • The purpose of this investigation was to investigate the embryological origin and the surgical management of abnormal parathyroid glands situated in the APW.
  • METHODS: The databases of patients operated on for primary, secondary, and tertiary hyperparathyroidism at eight European medical centers with a special interest in endocrine surgery were reviewed to identify those with APW adenomas.
  • The embryological origin was determined based on the number and position of identified parathyroid glands.
  • RESULTS: Nineteen (0.24%) APW parathyroid tumors were identified in 7,869 patients who underwent an operation for hyperparathyroidism (HPT) and 181 patients (2.3%) with mediastinal abnormal parathyroid glands.
  • Ten patients had primary, eight had secondary, and one had tertiary HPT.
  • In three patients, an APW adenoma was suspected by preoperative localization studies and was cured at the initial operation.
  • Evaluation of 17 patients who had bilateral neck exploration allowed us to determine the most probable origin of the APW parathyroid tumors: 12 were supernumerary, 4 appeared to originate from a superior, and 1 from an inferior gland.
  • CONCLUSIONS: Abnormal parathyroid glands situated in the APW are rare and usually identified after an unsuccessful cervical exploration.
  • The origin of these ectopically situated tumors is probably, as suggested by our data, from a supernumerary fifth parathyroid gland or from abnormal migration of a superior parathyroid gland during the embryologic development.
  • [MeSH-major] Adenoma / embryology. Choristoma / embryology. Mediastinal Diseases / embryology. Parathyroid Glands

  • Genetic Alliance. consumer health - Aortopulmonary Window.
  • ORBi (University of Liege). Free full Text at ORBi .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Surgery. 1987 Dec;102(6):917-25 [3317961.001]
  • [Cites] Radiology. 1996 Nov;201(2):456-62 [8888240.001]
  • [Cites] Surgery. 1994 Dec;116(6):999-1004; discussion 1004-5 [7985108.001]
  • [Cites] Ann Chir. 2000 Apr;125(3):247-52 [10829504.001]
  • [Cites] Presse Med. 1987 Feb 7;16(4):176 [2950455.001]
  • [Cites] J Am Coll Surg. 1997 Nov;185(5):481-5 [9358094.001]
  • [Cites] Jpn J Surg. 1990 Jul;20(4):481-6 [2201815.001]
  • [Cites] Ann Chir. 1989;43(5):393-6 [2667440.001]
  • [Cites] Henry Ford Hosp Med J. 1992;40(3-4):191-4 [1362403.001]
  • [Cites] Surgery. 1993 Dec;114(6):1011-8 [8256204.001]
  • [Cites] Langenbecks Arch Surg. 1998 Apr;383(2):174-9 [9641894.001]
  • [Cites] Am J Surg. 1982 Nov;144(5):511-7 [7137458.001]
  • [Cites] Ann Surg. 1941 Oct;114(4):706-33 [17857905.001]
  • [Cites] Chirurgie. 1988;114(2):166-73 [3215074.001]
  • [Cites] Mayo Clin Proc. 1982 Feb;57(2):121-4 [7054624.001]
  • [Cites] Surgery. 1984 Jan;95(1):14-21 [6691181.001]
  • [Cites] Arch Surg. 1996 Aug;131(8):861-7; discussion 867-9 [8712911.001]
  • [Cites] Med J Aust. 1986 Jul 21;145(2):92-4 [3736472.001]
  • [Cites] ANZ J Surg. 2003 May;73(5):284-8 [12752283.001]
  • [Cites] Ann Surg. 1977 Aug;186(2):140-5 [889360.001]
  • [Cites] Presse Med. 1996 Mar 23;25(10):494-6 [8685109.001]
  • [Cites] Am J Surg. 2005 May;189(5):601-4; discussion 605 [15862504.001]
  • [Cites] Am J Surg. 2008 Jun;195(6):799-802 [18436184.001]
  • [Cites] Ann Surg. 1981 Jun;193(6):805-9 [7247524.001]
  • [Cites] Surgery. 1988 Dec;104(6):1090-4 [3057671.001]
  • [Cites] World J Surg. 1988 Dec;12(6):818-24 [3250132.001]
  • [Cites] Metabolism. 1962 Jan;11:21-9 [13865885.001]
  • [Cites] World J Surg. 2000 Nov;24(11):1330-4 [11038202.001]
  • [Cites] J Clin Endocrinol Metab. 1994 Jan;78(1):77-82 [8288719.001]
  • [Cites] J Thorac Cardiovasc Surg. 2004 Jun;127(6):1831-2 [15173752.001]
  • [Cites] Radiology. 1993 Oct;189(1):137-41 [8372183.001]
  • [Cites] Ann Thorac Surg. 2001 Feb;71(2):699-701 [11235732.001]
  • [Cites] Surgery. 1982 Nov;92(5):814-21 [7135202.001]
  • [Cites] Arch Surg. 1988 Sep;123(9):1096-100 [3415460.001]
  • (PMID = 20523997.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  •  go-up   go-down


30. Thomas DL, Bartel T, Menda Y, Howe J, Graham MM, Juweid ME: Single photon emission computed tomography (SPECT) should be routinely performed for the detection of parathyroid abnormalities utilizing technetium-99m sestamibi parathyroid scintigraphy. Clin Nucl Med; 2009 Oct;34(10):651-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Single photon emission computed tomography (SPECT) should be routinely performed for the detection of parathyroid abnormalities utilizing technetium-99m sestamibi parathyroid scintigraphy.
  • RATIONALE: The current procedure guideline for performing dual-phase (DP) parathyroid scintigraphy, using technetium-99m sestamibi (Tc-99m MIBI) does not mandate the use of single photon emission computed tomography (SPECT) imaging for the detection of parathyroid adenoma (PA) or hyperplasia (PH).
  • The aim of our study was to determine whether DP SPECT (DPS) is significantly superior to DP planar (DPP) imaging in the detection of these abnormalities, justifying its routine use with Tc-99m MIBI parathyroid scintigraphy.
  • METHODS: Thirty-six consecutive patients with biochemically-proven hyperparathyroidism who subsequently underwent surgical evaluation were studied.
  • Overall, 29 adenomas and 24 hyperplastic glands were found at surgery.
  • CONCLUSIONS: DPS is significantly more sensitive, and at least as specific, compared with DPP in detecting parathyroid abnormalities in patients with primary hyperparathyroidism and should, therefore, be routinely used when DP Tc-99m MIBI is used in this setting.
  • An algorithm for best utilization of this technique to determine the appropriate surgical approach in patients with primary hyperparathyroidism is presented.
  • [MeSH-major] Parathyroid Glands / abnormalities. Parathyroid Glands / radionuclide imaging. Technetium Tc 99m Sestamibi. Tomography, Emission-Computed, Single-Photon

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19893394.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


31. Chan AP, Wan IY, Wong RH, Hsin MK, Underwood MJ: Robot-assisted excision of ectopic mediastinal parathyroid adenoma. Asian Cardiovasc Thorac Ann; 2010 Feb;18(1):65-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Robot-assisted excision of ectopic mediastinal parathyroid adenoma.
  • Robot-assisted excision of an ectopic parathyroid adenoma in the superior mediastinum was performed in a 57-year-old man.
  • Identification of the ectopic parathyroid adenoma was facilitated by the 3-dimensional images of the da Vinci robotic system, and resection was achieved using EndoWrist instruments.
  • Robot-assisted excision of parathyroid adenoma located in the relatively inaccessible superior mediastinum proved to be feasible.
  • [MeSH-major] Adenoma / surgery. Mediastinum / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods. Robotics / methods

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20124300.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  •  go-up   go-down


32. Shaheen F, Chowdry N, Gojwari T, Wani AI, Khan S: Role of cervical ultrasonography in primary hyperparathyroidism. Indian J Radiol Imaging; 2008 Nov;18(4):302-5
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of cervical ultrasonography in primary hyperparathyroidism.
  • AIM: To evaluate the role of USG in the preoperative localization of parathyroid adenomas in patients with symptomatic hyperparathyroidism and to compare its usefulness with that of scintigraphy scan and postoperative findings.
  • MATERIAL AND METHODS: Twenty-five patients with symptomatic primary hyperparathyroidism were subjected to USG of the neck and nuclear scintigraphy, followed by surgery.
  • RESULTS: The 25 patients had a total of 28 abnormal glands: 22 solitary adenomas, and 6 multiple adenomas (two each in three patients).
  • USG detected 20 out of 22 solitary adenomas and three out of six multiple adenomas.
  • CONCLUSION: As limited neck dissection for primary hyperparathyroidism becomes increasingly popular, USG has been found to be a sensitive, specific, and easily available noninvasive investigation for parathyroid localization.
  • It can be easily offered to patients as a method for preoperative localization prior to limited parathyroid surgery outside tertiary care settings.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Clin Endocrinol (Oxf). 1993 May;38(5):523-30 [8330447.001]
  • [Cites] Am J Surg. 1995 Nov;170(5):488-91 [7485739.001]
  • [Cites] Ann Surg. 1982 Mar;195(3):245-52 [7059236.001]
  • [Cites] Arch Surg. 2004 May;139(5):501-6; discussion 506-7 [15136350.001]
  • [Cites] Laryngoscope. 2003 Nov;113(11):1857-69 [14603039.001]
  • [Cites] J Am Coll Surg. 2003 Nov;197(5):739-46 [14585407.001]
  • [Cites] Int J Urol. 2003 Jan;10(1):7-11; discussion 12 [12534918.001]
  • [Cites] Ann Surg. 2002 Nov;236(5):552-3 [12409658.001]
  • [Cites] Eur J Nucl Med. 2001 Sep;28(9):1351-9 [11585294.001]
  • [Cites] Ann Chir. 2001 May;126(4):314-9 [11413810.001]
  • [Cites] Surgery. 1999 Dec;126(6):1016-21; discussion 1021-2 [10598182.001]
  • [Cites] World J Surg. 2004 Nov;28(11):1127-31 [15490069.001]
  • [Cites] Zentralbl Chir. 2005 Apr;130(2):109-13 [15849652.001]
  • [Cites] Surgery. 1999 Dec;126(6):1004-9; discussion 1009-10 [10598180.001]
  • [Cites] Semin Nucl Med. 1987 Oct;17(4):350-9 [3317848.001]
  • (PMID = 19774186.001).
  • [ISSN] 0971-3026
  • [Journal-full-title] The Indian journal of radiology & imaging
  • [ISO-abbreviation] Indian J Radiol Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2747464
  • [Keywords] NOTNLM ; Primary hyperparathyroidism / Tc-sestamibi scan / ultrasonography
  •  go-up   go-down


33. McGill J, Sturgeon C, Kaplan SP, Chiu B, Kaplan EL, Angelos P: How does the operative strategy for primary hyperparathyroidism impact the findings and cure rate? A comparison of 800 parathyroidectomies. J Am Coll Surg; 2008 Aug;207(2):246-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] How does the operative strategy for primary hyperparathyroidism impact the findings and cure rate? A comparison of 800 parathyroidectomies.
  • BACKGROUND: We hypothesized that a higher frequency of multigland disease and higher cure rate would result if routine four-gland exploration (4GL) was used as compared with focused parathyroidectomy (FP) for treatment of primary hyperparathyroidism.
  • STUDY DESIGN: During a 5-year period, data from two academic endocrine surgical practices were retrospectively reviewed for patients having an operation for primary hyperparathyroidism.
  • The main outcomes measures were gender, preoperative imaging, surgical findings, gland weight, and operative success.
  • At both institutions, single adenomas weighed more than multigland disease.
  • Gland weights were not significantly different between the two institutions.
  • Sound surgical technique and intraoperative judgment, including interpretation of intraoperative parathyroid hormone values, will result in a high success rate, regardless of the operative strategy chosen for primary hyperparathyroidism.
  • [MeSH-major] Adenoma / surgery. Hyperparathyroidism, Primary / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods
  • [MeSH-minor] Academic Medical Centers. Adult. Aged. Female. Humans. Hypercalcemia / blood. Hypercalcemia / etiology. Male. Middle Aged. Outcome and Process Assessment (Health Care). Parathyroid Hormone / blood. Postoperative Complications / blood. Postoperative Complications / etiology. Retrospective Studies

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18656054.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


34. Schachter PP, Ayesh S, Matouk I, Schneider T, Czerniak A, Hochberg A: Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue. Arch Pathol Lab Med; 2007 Jan;131(1):126-30
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue.
  • CONTEXT: Differentiation between adenoma and hyperplasia or even normal parathyroid tissue is difficult and based mainly on the surgeon's skill.
  • Exploration of genes that express differentially in these various tissues using microarrays and other sophisticated research tools will enable identification and perhaps development of new methods of perioperative diagnosis.
  • OBJECTIVE: To assemble a panel of kinase genes to differentiate parathyroid adenoma from normal and hyperplastic parathyroid tissue.
  • DESIGN: RNA was extracted from adenoma, hyperplasia, and normal parathyroid tissue and hybridized to a microarray containing 359 human cDNAs of known kinase genes.
  • RESULTS: The ratio values considered significant (<0.5 or >1.5) suggest that genes up-regulated in parathyroid adenoma are those responsible for blood vessel angiogenesis and genes belonging to the cyclin-dependent kinase inhibitor groups.
  • Genes down-regulated in parathyroid adenoma are related to cellular growth and apoptosis--genes from the mitogen-activated protein kinase group and DNA-dependent protein kinase group.
  • An interesting gene down-regulated in the parathyroid adenoma samples is related to the serine/threonine protein kinases that exert a key function in calcium handling.
  • CONCLUSIONS: The kinase genes panel presented can be used to differentiate parathyroid adenoma from normal and hyperplastic parathyroid tissue in particular when histopathology fails to provide a decisive diagnosis.
  • [MeSH-major] Adenoma / genetics. Hyperparathyroidism, Primary / genetics. Parathyroid Neoplasms / genetics. Phosphotransferases / genetics

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17227113.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.- / Phosphotransferases
  •  go-up   go-down


35. Sutbeyaz Y, Yoruk O, Bilen H, Gursan N: Primary hyperparathyroidism presenting as a palatal and mandibular brown tumor. J Craniofac Surg; 2009 Nov;20(6):2101-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism presenting as a palatal and mandibular brown tumor.
  • Primary hyperparathyroidism is a fairly frequent pathologic diagnosis characterized by hypersecretion of parathyroid hormone, which results from adenomas in 80% to 85% of all cases.
  • Brown tumors represent the terminal stage of the remodeling processes caused by an increased osteoclastic activity and fibroblastic proliferation during primary or secondary, albeit more seldom, hyperparathyroidism.
  • The manifestation of primary hyperparathyroidism as skeletal disease has nearly disappeared in the last 2 decades.
  • This article contains a case of brown tumor on the maxilla, palate, and mandible in addition to nephrectomy and proximal femur fracture, which are probably associated with primary hyperparathyroidism although less common nowadays.
  • The diagnosis was suggested by the clinical history and confirmed by biochemical, radiologic, and histopathologic evidence.
  • Excision of a parathyroid adenoma normalization of the metabolic status was then realized.
  • [MeSH-major] Adenoma / complications. Hyperparathyroidism, Primary / diagnosis. Hyperparathyroidism, Primary / etiology. Jaw Diseases / diagnosis. Osteitis Fibrosa Cystica / diagnosis. Parathyroid Neoplasms / complications
  • [MeSH-minor] Diagnosis, Differential. Fractures, Bone / etiology. Humans. Hypercalcemia / etiology. Male. Middle Aged. Nephrolithiasis / etiology

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - Jaw Injuries and Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19884850.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


36. Hussain R, Zaman MU, Ahmed MN: LOCALIZATION OF A PARATHYROID ADENOMA IN A MULTI-NODULAR GOITER USING SESTAMIBI AND Tc-99m PERTECHNETATE SCANS. J Coll Physicians Surg Pak; 2007 Nov;17(11):712-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] LOCALIZATION OF A PARATHYROID ADENOMA IN A MULTI-NODULAR GOITER USING SESTAMIBI AND Tc-99m PERTECHNETATE SCANS.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18070589.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  •  go-up   go-down


37. Moreno P, Francos JM, Shaha A, Bosch A, de Lama E, Rafecas A, Jaurrieta E: Intercostal video-assisted mediastinal surgery through an intercostal window (IVAMS): a simpler approach to perform mediastinal parathyroidectomy. Surgery; 2007 Sep;142(3):410-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Choristoma / surgery. Hyperparathyroidism / surgery. Parathyroidectomy / methods. Thoracic Diseases / surgery. Video-Assisted Surgery / methods
  • [MeSH-minor] Adenoma / complications. Adenoma / surgery. Aged. Female. Humans. Mediastinum / surgery. Parathyroid Glands. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - Chest Injuries and Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17723895.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


38. Levine MA: Primary hyperparathyroidism: 7,000 years of progress. Cleve Clin J Med; 2005 Dec;72(12):1084-5, 1088, 1091-2 passim
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism: 7,000 years of progress.
  • [MeSH-major] Hyperparathyroidism, Primary / etiology. Hyperparathyroidism, Primary / surgery
  • [MeSH-minor] Adenoma / complications. Calcium / blood. Humans. Parathyroid Hormone / blood. Parathyroid Neoplasms / complications

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [ErratumIn] Cleve Clin J Med. 2006 May;73(5):484
  • (PMID = 16392722.001).
  • [ISSN] 0891-1150
  • [Journal-full-title] Cleveland Clinic journal of medicine
  • [ISO-abbreviation] Cleve Clin J Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
  • [Number-of-references] 39
  •  go-up   go-down


39. Caliumi C, Cotesta D, Petramala L, Lorio M, Salvati M, Filetti S, De Toma G, D'Erasmo E, Letizia C: An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. Tumori; 2006 Mar-Apr;92(2):178-80
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma.
  • The case of a 50-year-old woman with cerebral meningioma and concomitant parathyroid adenoma and papillary thyroid carcinoma is presented.
  • Even though the patient's clinical condition was good, a calcium-phosphorus metabolism test confirmed high plasma levels of ionized calcium and parathyroid hormone.
  • Thyroid and parathyroid ultrasonography revealed multinodular goiter and a parathyroid lesion confirmed by 99mTc-TCO4 / 99mTc-MIBI scintigraphy.
  • Histological examination revealed a parathyroid adenoma and a small papillary carcinoma of 0.4 cm in the right thyroid lobe.
  • As far as we know, this patient is the third case of meningioma associated with parathyroid adenoma and papillary thyroid carcinoma described in the literature.
  • [MeSH-major] Adenoma / diagnosis. Brain Neoplasms / diagnosis. Carcinoma, Papillary / diagnosis. Meningioma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parathyroid Neoplasms / diagnosis. Thyroid Neoplasms / diagnosis


40. Das K, Stone N, Kendall C, Fowler C, Christie-Brown J: Raman spectroscopy of parathyroid tissue pathology. Lasers Med Sci; 2006 Dec;21(4):192-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Raman spectroscopy of parathyroid tissue pathology.
  • Primary hyperparathyroidism (HPT) in 80% of patients is due to a solitary parathyroid adenoma, while in 20% multigland pathology exists, usually hyperplasia [Scott-Coombes, Surgery, 21(12):309-312, 2003].
  • Despite recent advances in minimally invasive parathyroidectomy, better preoperative localisation techniques and intraoperative parathyroid hormone (PTH) monitoring, a 4% failure rate [Grant CS, Thompson G, Farley D, Arch Surg, 140:47-479, 2005] persists making accurate differentiation between adenomas and hyperplasia of prime importance.
  • We investigated the ability of Raman spectroscopy to accurately differentiate between parathyroid adenomas and hyperplasia.
  • Raman spectra were measured at defined points on the parathyroid tissue sections using a bench-top microscopy system.
  • Multivariate analysis of the spectra was carried out to construct a diagnostic algorithm correlating spectral results with the histopathological diagnosis.
  • Detection sensitivity for parathyroid adenomas was 95% and hyperplasia was 93%.
  • These preliminary results indicate that Raman spectroscopy is potentially an excellent tool to differentiate between parathyroid adenomas and hyperplasia.
  • [MeSH-major] Parathyroid Glands / pathology. Parathyroid Neoplasms / pathology. Spectrum Analysis, Raman
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Humans. Hyperparathyroidism, Primary / pathology. Hyperplasia. Multivariate Analysis. Sensitivity and Specificity

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Pathol. 1935 Jan;11(1):1-72.17 [19970186.001]
  • [Cites] J Biomed Opt. 1996 Jan;1(1):31-70 [23014644.001]
  • [Cites] Hum Pathol. 1985 Dec;16(12 ):1255-63 [2415441.001]
  • [Cites] Am J Surg Pathol. 1982 Mar;6(2):191-2 [6179431.001]
  • [Cites] Arch Surg. 2005 May;140(5):472-8; discussion 478-9 [15897443.001]
  • [Cites] Am J Clin Pathol. 1968 Jun;49(6):761-75 [5654505.001]
  • [Cites] J Clin Pathol. 2005 Apr;58(4):338-42 [15790694.001]
  • [Cites] J Pathol. 2003 Aug;200(5):602-9 [12898596.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12371-6 [16116095.001]
  • [Cites] Am J Pathol. 1984 Apr;115(1):70-83 [6711681.001]
  • [Cites] Monogr Pathol. 1993;(35):34-62 [8502251.001]
  • (PMID = 17024320.001).
  • [ISSN] 0268-8921
  • [Journal-full-title] Lasers in medical science
  • [ISO-abbreviation] Lasers Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


41. Verlaan L, van der Wal B, de Maat GJ, Walenkamp G, Nollen-Lopez L, van Ooij A: Primary hyperparathyroidism and pathological fractures: a review. Acta Orthop Belg; 2007 Jun;73(3):300-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism and pathological fractures: a review.
  • Primary hyperparathyroidism is due most often to a parathyroid adenoma secreting parathyroid hormone.
  • [MeSH-major] Fractures, Spontaneous / etiology. Hyperparathyroidism, Primary / complications

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17715718.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 28
  •  go-up   go-down


42. Gayed IW, Kim EE, Broussard WF, Evans D, Lee J, Broemeling LD, Ochoa BB, Moxley DM, Erwin WD, Podoloff DA: The value of 99mTc-sestamibi SPECT/CT over conventional SPECT in the evaluation of parathyroid adenomas or hyperplasia. J Nucl Med; 2005 Feb;46(2):248-52
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of 99mTc-sestamibi SPECT/CT over conventional SPECT in the evaluation of parathyroid adenomas or hyperplasia.
  • This retrospective study evaluated the clinical value of simultaneously acquired (99m)Tc-sestamibi SPECT/CT versus conventional SPECT in diagnosing and locating parathyroid adenomas or hyperplasia in patients with primary hyperparathyroidism.
  • Two experienced masked readers independently evaluated whether conventional SPECT images provided information beyond what was available from the planar images either by changing the diagnosis or by better locating the glands and whether the SPECT/CT images provided information beyond what was available from the planar plus conventional SPECT images.
  • Forty-eight consecutive patients with a clinical diagnosis of primary hyperparathyroidism were included in the study.
  • RESULTS: Planar and SPECT imaging, with or without CT fusion, identified 89% of the surgically confirmed diseased parathyroid glands.
  • Use of SPECT/CT changed the diagnosis in only 1 patient (2%) from positive to negative and better located the glands in only 4 patients (8%).
  • SPECT/CT was particularly helpful in locating the 2 ectopic parathyroid adenomas diagnosed in this cohort.
  • CONCLUSION: SPECT/CT has no significant clinical value additional to that of conventional SPECT for parathyroid imaging except in locating ectopic parathyroid glands.
  • [MeSH-major] Adenoma / radiography. Adenoma / radionuclide imaging. Hyperparathyroidism / radiography. Hyperparathyroidism / radionuclide imaging. Parathyroid Neoplasms / radiography. Parathyroid Neoplasms / radionuclide imaging. Subtraction Technique. Technetium Tc 99m Sestamibi
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Hyperplasia. Image Enhancement / methods. Male. Middle Aged. Radiopharmaceuticals. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15695783.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


43. Turgut B, Elagoz S, Erselcan T, Koyuncu A, Dokmetas HS, Hasbek Z, Ozdemir S, Aydin C: Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume. Cancer Biother Radiopharm; 2006 Dec;21(6):579-90
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume.
  • In addition to tumor size, it has been suggested that P-glycoprotein (P-gp) expression and/or oxyphilic cell content in parathyroid adenomas has an important influence on the results of technetium 99m methoxyisobutylisonitrile (Tc-99m MIBI) parathyroid imaging.
  • AIM: In this study, we compared the results of MIBI parathyroid imaging and immunohistochemical analysis (IHA) of P-gp expression, oxyphilic cell content, and tumoral tissue volume in parathyroid adenomas.
  • MATERIALS AND METHODS: Forty (40) patients (36 female and 4 male; mean age, 53.2 +/- 8.16 years) with hyperparathyroidism who had undergone surgery were included in this study.
  • Preoperatively, "double phase" parathyroid scintigraphy with Tc-99m MIBI (including imaging of the neck and mediastinum) was performed in all patients.
  • In resected parathyroid tissues, P-gp expression and percentage of oxyphilic cell content were analyzed with IHA in 34 patients.
  • RESULTS: Three (3) of the resected parathyroid tissues were hyperplastic parathyroid tissue, whereas 31 of the tissues were parathyroid adenoma (mean volume, 1.99 +/- 1.93 mL).
  • In Tc-99m MIBI parathyroid scintigraphy, 70% of the parathyroid adenoma/hyperplastic parathyroid tissue was detected in correct localization; at US, this rate was 46.8%.
  • According to the resected parathyroid tissue localization at surgery, sensitivity, accuracy, positive predictive value, and prevalence in scintigraphy were 82.3%, 70%, 82.3%, and 85%, respectively.
  • In 12 of 19 patients (63%) who had parathyroid tissue < 1 mL and in 15 of 24 patients (62.5%) who had oxyphilic cell content < 10%, lesions were also detected correctly with MIBI scintigraphy.
  • However, P-gp expression, oxyphilic cell content, and tumoral volume may have not a main effect on MIBI parathyroid scintigraphy results in parathyroid adenoma.
  • [MeSH-major] Organotechnetium Compounds. Oxyphil Cells / metabolism. Oxyphil Cells / pathology. P-Glycoproteins / metabolism. Parathyroid Neoplasms / metabolism. Parathyroid Neoplasms / radiography

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17257073.001).
  • [ISSN] 1084-9785
  • [Journal-full-title] Cancer biotherapy & radiopharmaceuticals
  • [ISO-abbreviation] Cancer Biother. Radiopharm.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / P-Glycoproteins
  •  go-up   go-down


44. Koksal H: The clinicians' aspects of parathyroid adenomas. Laryngoscope; 2007 Feb;117(2):382; author reply 382-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinicians' aspects of parathyroid adenomas.
  • [MeSH-major] Adenoma / ultrasonography. Parathyroid Neoplasms / ultrasonography. Radiopharmaceuticals. Technetium Tc 99m Sestamibi

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] Laryngoscope. 2006 Aug;116(8):1380-4 [16885740.001]
  • (PMID = 17277637.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


45. Miller B: SPUS Facilitates MIP. World J Surg; 2008 May;32(5):772-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenoma / diagnostic imaging. Adenoma / surgery. Parathyroid Neoplasms / diagnostic imaging. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] World J Surg. 2008 May;32(5):766-71 [18224474.001]
  • [Cites] World J Surg. 2004 Nov;28(11):1122-6 [15490067.001]
  • [Cites] J Am Coll Surg. 2006 Jan;202(1):18-24 [16377493.001]
  • (PMID = 18219466.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Comment
  • [Publication-country] United States
  •  go-up   go-down


46. Cebesoy O, Karakok M, Arpacioglu O, Baltaci ET: Brown tumor with atypical localization in a normocalcemic patient. Arch Orthop Trauma Surg; 2007 Sep;127(7):577-80
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Brown tumor is a bone lesion secondary to hyperparathyroidism of various etiologies.
  • Hyperparathyroidism is usually associated with high levels of calcium.
  • Being normocalcemic and having the tumor on foot only without any other skeletal system involvement have led to a difficulty in establishing the diagnosis in our case.
  • Even though serum calcium levels are routinely checked in many clinics parathormone levels should also be looked for differential diagnosis, as this case confirms, in cases with osteolytic bone tumors that causes expansion even if the patient is normocalcemic.
  • [MeSH-major] Adenoma / pathology. Bone Neoplasms / secondary. Metatarsal Bones / pathology. Parathyroid Neoplasms / diagnosis

  • MedlinePlus Health Information. consumer health - Bone Cancer.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17377798.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] SY7Q814VUP / Calcium
  •  go-up   go-down


47. Ogilvie JB, Clark OH: Parathyroid surgery: we still need traditional and selective approaches. J Endocrinol Invest; 2005 Jun;28(6):566-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid surgery: we still need traditional and selective approaches.
  • Since the first parathyroidectomy in 1925, the traditional bilateral cervical approach has been the gold standard surgical treatment for patients with primary hyperparathyroidism, with a success rate >95%.
  • Over the past decade, the focus on minimally invasive surgery has led to the development of several innovative approaches to the parathyroid glands including the focused, radio-guided, video-assisted and videoscopic parathyroidectomy.
  • Improvements in pre-operative parathyroid localization studies as well as the use of the intraoperative PTH assay have made these minimally invasive approaches possible, and they have been proven to be safe and effective for the solitary parathyroid adenoma.
  • For patients with multiple gland disease or equivocal localization studies, the traditional bilateral approach remains the standard of care.
  • [MeSH-major] Parathyroid Diseases / surgery. Parathyroidectomy / methods
  • [MeSH-minor] Adenoma / surgery. Humans. Hyperparathyroidism / surgery. Parathyroid Glands / surgery. Parathyroid Hormone / blood. Parathyroid Neoplasms / surgery. Reoperation. Thyroid Neoplasms / complications. Thyroid Neoplasms / surgery. Ultrasonography

  • MedlinePlus Health Information. consumer health - Parathyroid Disorders.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Endocrinol Invest. 2005 Jun;28(6):570-3 [16117202.001]
  • [Cites] Arch Surg. 2003 Oct;138(10):1140-3 [14557134.001]
  • [Cites] Acta Chir Scand. 1988 Jul-Aug;154(7-8):409-13 [3188787.001]
  • [Cites] Ann Surg. 2002 Nov;236(5):543-51 [12409657.001]
  • [Cites] Surgery. 2003 Dec;134(6):995-1003; discussion 1003-4 [14668733.001]
  • [Cites] World J Surg. 2001 Jun;25(6):704-7 [11376402.001]
  • [Cites] Surgery. 2001 Dec;130(6):1005-10 [11742330.001]
  • [Cites] J Am Coll Surg. 2004 Feb;198(2):185-9 [14759773.001]
  • [Cites] Adv Endocrinol Metab. 1995;6:1-16 [7671092.001]
  • [Cites] Ann Surg. 1976 Oct;184(4):391-402 [1015886.001]
  • [Cites] Thyroid. 2002 Dec;12(12):1109-12 [12593724.001]
  • [Cites] Ann Surg. 1999 Jun;229(6):874-8; discussion 878-9 [10363902.001]
  • [Cites] J Am Coll Surg. 2003 Apr;196(4):535-40 [12691927.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Mar;87(3):1024-9 [11889156.001]
  • [Cites] J Am Coll Surg. 2003 Nov;197(5):739-46 [14585407.001]
  • [Cites] Surgery. 1999 Dec;126(6):1139-43; discussion 1143-4 [10598199.001]
  • [Cites] Surgery. 2002 Dec;132(6):1094-8; discussion 1098-9 [12490860.001]
  • [Cites] J Clin Endocrinol Metab. 1998 Aug;83(8):2658-65 [9709928.001]
  • [Cites] Br J Surg. 1996 Jun;83(6):875 [8696772.001]
  • [Cites] Surgery. 1997 Dec;122(6):998-1003; discussion 1003-4 [9426412.001]
  • [Cites] Surgery. 2003 Dec;134(6):1049-55; discussion 1056 [14668740.001]
  • [Cites] J Laparoendosc Adv Surg Tech A. 1998 Aug;8(4):189-94 [9755909.001]
  • (PMID = 16117201.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


48. Simsek E, Arikan Y, Dallar Y, Akkus MA: Prolonged hungry bone syndrome in a 10-year-old child with parathyroid adenoma. Indian Pediatr; 2009 Feb;46(2):178-80
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prolonged hungry bone syndrome in a 10-year-old child with parathyroid adenoma.
  • We report a case of primary hyperparathyroidism associated with prolonged hungry syndrome (HBS) after parathyroid adenomectomy in a 10-year-old girl.
  • Overt bone disease, high alkaline phosphatase, decreased cancellous BMD and a large adenoma can be used as preoperative predictive risk factors of HBS in children.
  • [MeSH-major] Adenoma / surgery. Hypocalcemia / etiology. Parathyroid Neoplasms / surgery
  • [MeSH-minor] Bone Density. Bone Resorption. Calcium / administration & dosage. Calcium / blood. Child. Female. Humans. Hyperparathyroidism, Primary / complications. Hyperparathyroidism, Primary / surgery. Syndrome

  • Genetic Alliance. consumer health - CHILD Syndrome.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19242040.001).
  • [ISSN] 0019-6061
  • [Journal-full-title] Indian pediatrics
  • [ISO-abbreviation] Indian Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] SY7Q814VUP / Calcium
  •  go-up   go-down


49. Romani AM, Panarese A, Pironi D, Zeri KP, Candioli S, Manigrasso A, Filippini A: [Parathyroid carcinoma: clinical case and review of the literature]. G Chir; 2006 Apr;27(4):169-72
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Parathyroid carcinoma: clinical case and review of the literature].
  • [Transliterated title] Carcinoma paratiroideo: caso clinico e revisione della letteratura.
  • INTRODUCTION: Parathyroid carcinoma is a rare endocrine neoplasm, difficult to define clinically and histopathologically.
  • Laboratory findings (PTH 580 pg/ml; Ca 12.40 mg/dl; P 1.9 mg/dl), echography, TC, and parathyroid scintigraphy, associated with clinical data, have suggested hypothesis of parathyroid carcinoma confirmed by histological examination and immunochemistry.
  • DISCUSSION AND CONCLUSION: No clinical or bio-humoral data allows a preoperative diagnosis of parathyroid carcinoma.
  • Only with definitive pathology and immunohistochemistry it is possible to differentiate an adenoma from a carcinoma.
  • [MeSH-major] Carcinoma. Parathyroid Neoplasms

  • Genetic Alliance. consumer health - Parathyroid carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16768874.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 21
  •  go-up   go-down


50. Henry JF: Reoperation for primary hyperparathyroidism: tips and tricks. Langenbecks Arch Surg; 2010 Feb;395(2):103-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reoperation for primary hyperparathyroidism: tips and tricks.
  • Reoperation for primary hyperparathyroidism (PHPT) remains a major challenge for both the patient and surgeons.
  • Before considering reoperation, the surgeon must confirm the diagnosis of PHPT and assess patient risk factors.
  • The goal of reoperative surgery is to excise the abnormal parathyroid gland(s) and limit exploration to help minimize the potential complications.
  • A thorough knowledge of the anatomy and an understanding of the embryonic development of the parathyroid glands are also the keys to successful localization.
  • If the lesion sought is a solitary adenoma, an open-focused approach can be proposed.
  • In some cases, cryopreservation of parathyroid tissue and judicious use of parathyroid transplantation can be useful.
  • With experienced parathyroid surgeons, the success rate of reoperations can be as high as 95%.
  • It is too early to evaluate the real risk of persistent or recurrent disease following minimally invasive techniques, but any attempt to limit the extent of the primary procedure will be insignificant if the risk of persistent or recurrent disease is increased.
  • [MeSH-major] Hyperparathyroidism / surgery. Reoperation / methods
  • [MeSH-minor] Adenoma / complications. Carcinoma / complications. Cryopreservation. Humans. Medical History Taking. Minimally Invasive Surgical Procedures / methods. Neoplasm Recurrence, Local / complications. Parathyroid Glands / abnormalities. Parathyroid Glands / embryology. Parathyroid Glands / transplantation. Parathyroid Neoplasms / complications. Patient Selection. Recurrence. Risk Assessment. Risk Factors. Time Factors. Transplantation, Autologous. Treatment Outcome

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] World J Surg. 2003 Feb;27(2):212-5 [12616439.001]
  • [Cites] World J Surg. 1991 Jul-Aug;15(4):546-9; discussion 549-50 [1891942.001]
  • [Cites] Surgery. 2008 Oct;144(4):611-9; discussion 619-21 [18847646.001]
  • [Cites] Am J Surg. 1960 Apr;99:394-403 [13811831.001]
  • [Cites] Surgery. 1992 Dec;112(6):1123-9 [1455314.001]
  • [Cites] Surgery. 2007 Dec;142(6):819-22; discussion 822.e1 [18063062.001]
  • [Cites] Surgery. 1978 Sep;84(3):384-93 [98860.001]
  • [Cites] Ann Surg. 1996 Sep;224(3):308-20; discussion 320-1 [8813259.001]
  • [Cites] Langenbecks Arch Surg. 1998 Apr;383(2):174-9 [9641894.001]
  • [Cites] World J Surg. 1990 May-Jun;14(3):342-8 [2368436.001]
  • [Cites] Arch Surg. 1996 Aug;131(8):861-7; discussion 867-9 [8712911.001]
  • [Cites] Ann Surg. 1977 Aug;186(2):140-5 [889360.001]
  • [Cites] World J Surg. 1987 Feb;11(1):110-4 [3811380.001]
  • [Cites] Br J Surg. 1997 Jan;84(1):98-100 [9043469.001]
  • [Cites] Arch Surg. 1999 Jul;134(7):699-704; discussion 704-5 [10401818.001]
  • [Cites] World J Surg. 2003 Jun;27(6):675-9 [12734681.001]
  • [Cites] J Clin Endocrinol Metab. 1993 May;76(5):1373-5 [7684395.001]
  • [Cites] Ann Intern Med. 1980 Mar;92(3):351-6 [7356229.001]
  • (PMID = 19924438.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Lectures
  • [Publication-country] Germany
  •  go-up   go-down


51. Choi H, Kim S, Moon JH, Lee YH, Rhee Y, Kang ES, Ahn CW, Cha BS, Lee EJ, Kim KR, Lee HC, Jeong SY, Kim HJ, Lim SK: Multiple endocrine neoplasia type 1 with multiple leiomyomas linked to a novel mutation in the MEN1 gene. Yonsei Med J; 2008 Aug 30;49(4):655-61
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MEN1 is characterized by the presence of functioning and nonfunctioning tumors or hyperplasia of the pituitary gland, parathyroid glands, and pancreatic islet cells.
  • Biochemical abnormalities included hypercalcemia with elevated parathyroid hormone.
  • This is the first case of MEN1 accompanied with multiple leiomyomas, parathyroid adenoma, pituitary adenoma, pancreatic tumor, and adrenal tumor.


52. Freriks K, den Heijer M, Bonenkamp JJ, Biert J, Sweep CG, Hermus AR: [Intraoperative parathyroid hormone measurement in patients with primary hyperparathyroidism; particularly valuable for suspected solitary parathyroid adenoma and re-operation]. Ned Tijdschr Geneeskd; 2008 Jan 5;152(1):28-32
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intraoperative parathyroid hormone measurement in patients with primary hyperparathyroidism; particularly valuable for suspected solitary parathyroid adenoma and re-operation].
  • OBJECTIVE: Analysis of the value of intraoperative parathormone (PTH) measurement in patients with primary hyperparathyroidism.
  • The success rate was correctly predicted as follows: in subgroups of patients with MEN-1 syndrome, 85%, patients after exclusion of MEN-1, 94%, and patients in whom a solitary adenoma was likely after preoperative localization studies, 97%.
  • In 13% of the total number of operations, PTH-measurements led to further exploration, removal of additional parathyroid tissue and normocalcemia postoperatively.
  • In patients without MEN-1 syndrome, in whom a solitary adenoma was likely on the basis of preoperative investigations, it was possible to limit the operation to a unilateral procedure in 87%.
  • CONCLUSION: In the majority of patients with primary hyperparathyroidism, intraoperative PTH-measurement in combination with preoperative imaging studies leads to patients being cured with a unilateral instead of a bilateral operation.
  • [MeSH-major] Adenoma / surgery. Hyperparathyroidism, Primary / blood. Monitoring, Intraoperative / methods. Parathyroid Hormone / blood. Parathyroid Neoplasms / surgery

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18240759.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


53. Haglund F, Andreasson A, Nilsson IL, Höög A, Larsson C, Juhlin CC: Lack of S37A CTNNB1/β-catenin mutations in a Swedish cohort of 98 parathyroid adenomas. Clin Endocrinol (Oxf); 2010 Oct;73(4):552-3
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lack of S37A CTNNB1/β-catenin mutations in a Swedish cohort of 98 parathyroid adenomas.
  • [MeSH-major] Adenoma / genetics. Mutation. Parathyroid Neoplasms / genetics. beta Catenin / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20550535.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / beta Catenin
  •  go-up   go-down


54. Liu J, Wang JD: [Diagnosis and treatment of primary parathyroid carcinoma: report of 2 cases]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Feb;43(2):150-1
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnosis and treatment of primary parathyroid carcinoma: report of 2 cases].
  • [MeSH-major] Adenoma / diagnosis. Adenoma / therapy. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / therapy

  • Genetic Alliance. consumer health - Parathyroid carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18510227.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  •  go-up   go-down


55. Moore FD Jr: Are scintigraphy, ultrasonography, and the parathyroid hormone assay necessary to identify solitary parathyroid adenomas? Nat Clin Pract Endocrinol Metab; 2007 Mar;3(3):214-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are scintigraphy, ultrasonography, and the parathyroid hormone assay necessary to identify solitary parathyroid adenomas?

  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] Clin Endocrinol (Oxf). 2006 Jul;65(1):106-13 [16817828.001]
  • (PMID = 17262065.001).
  • [ISSN] 1745-8366
  • [Journal-full-title] Nature clinical practice. Endocrinology & metabolism
  • [ISO-abbreviation] Nat Clin Pract Endocrinol Metab
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
  •  go-up   go-down


56. Toi PCh, Varghese RG, Ramdas A, Dasiah SD: Case report of parathyroid carcinoma with raised urinary catecholamines: a diagnostic dilemma. Indian J Pathol Microbiol; 2007 Apr;50(2):389-91
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report of parathyroid carcinoma with raised urinary catecholamines: a diagnostic dilemma.
  • Parathyroid carcinoma is often misdiagnosed as thyroid carcinoma clinically and also with fine needle aspiration cytology.
  • Moreover in cases misdiagnosed as thyroid carcinoma pre operatively, raised urinary catecholamines may mislead to a diagnosis of MEN2 A.
  • We report a case of a patient admitted to the surgery department ofour hospital with a swelling in the thyroid region, raised urinary catecholamines and urinary VMA levels, with hypercalciuria and elevated parathyroid hormone levels.
  • It was clinically suspected as thyroid carcinoma with parathyroid adenoma and associated MEN 2A syndrome.
  • [MeSH-major] Catecholamines / urine. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / urine
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Multiple Endocrine Neoplasia Type 2a / diagnosis. Thyroid Neoplasms / diagnosis. Vanilmandelic Acid / urine

  • Genetic Alliance. consumer health - Parathyroid carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17883086.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Catecholamines; 55-10-7 / Vanilmandelic Acid
  •  go-up   go-down


57. Bonnichon P, Thillois JM, Amiel B: [Resection of parathyroid adenoma under local anesthesia]. J Chir (Paris); 2006 Mar-Apr;143(2):109-10
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Resection of parathyroid adenoma under local anesthesia].
  • [MeSH-major] Adenoma / surgery. Anesthesia, Local. Parathyroid Neoplasms / surgery

  • Hazardous Substances Data Bank. PROCAINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16788553.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anesthetics, Local; 4Z8Y51M438 / Procaine
  •  go-up   go-down


58. Marienhagen K, Due J, Hanssen TA, Svartberg J: Surviving extreme hypercalcaemia--a case report and review of the literature. J Intern Med; 2005 Jul;258(1):86-9
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case of extreme hypercalcaemia associated with a parathyroid adenoma in a young man.
  • The patient presented with classical symptoms of a hypercalcaemic syndrome, and serum calcium and parathyroid hormone levels were 6.92 mmol L(-1) and 70.2 pmol L(-1) respectively.
  • Hypercalcaemic crisis is a rare but life-threatening complication of primary hyperparathyroidism.
  • [MeSH-major] Adenoma / complications. Hypercalcemia / etiology. Parathyroid Neoplasms / complications
  • [MeSH-minor] Adult. Calcium / blood. Humans. Hyperparathyroidism / blood. Hyperparathyroidism / etiology. Hyperparathyroidism / surgery. Male. Parathyroidectomy / methods. Treatment Outcome

  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15953136.001).
  • [ISSN] 0954-6820
  • [Journal-full-title] Journal of internal medicine
  • [ISO-abbreviation] J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] SY7Q814VUP / Calcium
  • [Number-of-references] 16
  •  go-up   go-down


59. Krishnamoorthy P, Alyaarubi S, Abish S, Gale M, Albuquerque P, Jabado N: Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease. Pediatrics; 2006 Aug;118(2):e537-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease.
  • We report a case of bone pain associated with primary hyperparathyroidism in a patient with sickle cell disease.
  • Phosphorus level was 0.82 mmol/L (range: 0.90-1.50), alkaline phosphatase level was elevated at 519 U/L (range: 10-170), and parathyroid hormone level was extremely high at 1645 pg/mL (range: 10-60).
  • Ultrasonography of the neck and a Sestamibi scan revealed a single left inferior parathyroid adenoma adjacent to the thyroid lobe.
  • The patient was diagnosed with primary hyperparathyroidism.
  • Fluid hydration, hydrocortisone, calcitonin, and bisphosphonates were initiated for acute hypercalcemia management before surgical excision of the left parathyroid adenoma.
  • Two years postsurgery, she has normal renal function, calcium, and parathyroid hormone levels.
  • The decrease in pain episodes, even if it coincided with the treatment of primary hyperparathyroidism, may still reflect the natural evolution of sickle cell disease in this patient.
  • However, the high morbidity associated with primary hyperparathyroidism was successfully prevented in this patient.
  • Primary hyperparathyroidism is rare in childhood.
  • In a recent study, it occurred more commonly in female adolescents and was because of a single adenoma, as in our patient.
  • Significant morbidity, mainly secondary to renal dysfunction, was because of the delay in diagnosis after the onset of symptoms (2.0-4.2 years), emphasizing the need for a rapid diagnosis.
  • There is no known association between sickle cell disease and primary hyperparathyroidism, and this case is most probably a random occurrence.
  • Because management may vary, we suggest that care providers consider the diagnosis of vaso-occlusive crisis as the diagnosis of exclusion and that other etiologies for pain be envisaged in this patient population, especially in the presence of prolonged pain or unusual clinical, radiologic, or biological findings.
  • [MeSH-major] Adenoma / complications. Anemia, Sickle Cell / complications. Arthralgia / etiology. Back Pain / etiology. Hyperparathyroidism / diagnosis. Knee Joint. Parathyroid Neoplasms / complications. Vascular Diseases / diagnosis
  • [MeSH-minor] Adolescent. Analgesics, Opioid / therapeutic use. Bone Resorption / etiology. Diagnosis, Differential. Emergency Service, Hospital. Female. Humans. Hydroxyurea / therapeutic use. Hypercalcemia / etiology. Parathyroid Hormone / blood. Recurrence. Treatment Refusal


60. Enomoto K, Sakurai K, Amano S: [Experience of parathyroid cancer which required a differentiation from adenoma]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2325-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Experience of parathyroid cancer which required a differentiation from adenoma].
  • We noted a thyroid gland mass by examination and referred for a further checkup.
  • The cervical echography evidence showed a mass image of the border regular in the back of inferior pole of left thyroid gland.
  • It also revealed a mass image with the calcification in the inferior pole of left lobe of thyroid gland at the same time.
  • We performed aspiration biopsy cytology for a thyroid gland mass, and it was class IIIa.
  • We also performed parathyroidectomy and left lobe of thyroid gland ablative surgery because of a diagnosis of the hyperparathyroidism confirmed a primary parathyroid adenoma.
  • Preoperative pathological diagnosis was adenoma.
  • However, histopathology laboratory findings showed it to be of adenocarcinoma of the parathyroid, which metastasized into the thyroid.
  • Many times parathyroid cancer preoperative diagnosis is inconclusive.
  • So we are reporting our experience with parathyroid cancer metastases to the thyroid for reference.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Hyperparathyroidism / etiology. Hyperparathyroidism / surgery. Male. Parathyroidectomy. Thyroid Neoplasms / secondary. Thyroidectomy

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21224561.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


61. Tamsen F, Reihner E, Danielsson R, Nordenström J: [Sestamibi scintigraphy in primary hyperthyroidism. A not completely reliable method--should be reserved for certain patients]. Lakartidningen; 2007 May 14-29;104(20-21):1600-2
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Sestamibi scintigraphy in primary hyperthyroidism. A not completely reliable method--should be reserved for certain patients].
  • [MeSH-major] Hyperparathyroidism, Primary / radionuclide imaging. Parathyroid Glands / radionuclide imaging
  • [MeSH-minor] Adenoma / radionuclide imaging. Adenoma / surgery. Adult. Aged. Cost-Benefit Analysis. Female. Humans. Male. Middle Aged. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / surgery. Predictive Value of Tests. Preoperative Care. Radiopharmaceuticals. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Sodium Pertechnetate Tc 99m. Technetium Tc 99m Sestamibi

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17564269.001).
  • [ISSN] 0023-7205
  • [Journal-full-title] Läkartidningen
  • [ISO-abbreviation] Lakartidningen
  • [Language] swe
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi; A0730CX801 / Sodium Pertechnetate Tc 99m
  •  go-up   go-down


62. Komaba H, Takeda Y, Shin J, Tanaka R, Kakuta T, Tominaga Y, Fukagawa M: Reversed whole PTH/intact PTH ratio as an indicator of marked parathyroid enlargement: five case studies and a literature review. NDT Plus; 2008 Aug;1(Suppl 3):iii54-iii58
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reversed whole PTH/intact PTH ratio as an indicator of marked parathyroid enlargement: five case studies and a literature review.
  • Parathyroid hormone (PTH) levels detected by intact PTH assays are generally higher than those detected by the whole PTH assay because the latter does not detect non-(1-84) PTH fragments, mainly PTH (7-84).
  • Rare exceptions to this rule have been reported in patients with severe primary or secondary hyperparathyroidism and parathyroid carcinoma.
  • We report five additional cases with the reversed whole PTH/intact PTH ratio associated with severe hyperparathyroidism in haemodialysis patients.
  • Three patients demonstrated enlargement of a single hypervascular gland, whereas the other two had undergone surgical parathyroidectomy and later showed recurrent hyperparathyroidism due to progressive autograft hyperplasia.
  • In the case of a single enlarged gland, the pathological pattern and heterogeneous expression of parathyroid adenomatosis 1/cyclin D1 suggested it to be a single nodule of uraemic hyperparathyroidism rather than sporadic primary adenoma.
  • These cases suggested that the reversed whole PTH/intact PTH ratio could be an indicator of marked parathyroid enlargement.

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 25983975.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4421125
  • [Keywords] NOTNLM ; N-PTH / intact PTH / secondary hyperparathyroidism / single nodule / whole PTH
  •  go-up   go-down


63. Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO: Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract; 2009 Jul-Aug;15(5):463-8
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism.
  • OBJECTIVE: To describe a patient presenting with the rare constellation of synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma.
  • RESULTS: The patient was a 59-year-old man who presented with severe clinical manifestations of long-standing primary hyperparathyroidism, a serum calcium concentration of 14.4 mg/dL, and a parathyroid hormone level of 2,023 pg/mL.
  • He was found to have a 3.4-cm parathyroid carcinoma on the left side and a 3.2-cm papillary carcinoma in the right thyroid lobe.
  • In addition, a 917-mg parathyroid adenoma was found on the right side.
  • CONCLUSION: Synchronous parathyroid and thyroid carcinomas are extremely rare.
  • To our knowledge, our patient is the first documented case with a parathyroid adenoma in addition to synchronous parathyroid and thyroid carcinomas.
  • The presence of concurrent parathyroid carcinoma and parathyroid adenoma can cause diagnostic confusion and should be considered in patients presenting with severe hyperparathyroidism.

  • Genetic Alliance. consumer health - Parathyroid carcinoma.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Ear Nose Throat J. 2002 Jun;81(6):395-8, 400-1 [12092283.001]
  • [Cites] Cancer. 2007 Jul 15;110(2):255-64 [17559137.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Feb;86(2):485-93 [11157996.001]
  • [Cites] Surg Oncol. 1999 Nov;8(3):155-65 [11113666.001]
  • [Cites] Mayo Clin Proc. 2002 Aug;77(8):866-9 [12173721.001]
  • [Cites] Am J Otolaryngol. 2002 Nov-Dec;23(6):382-5 [12430133.001]
  • [Cites] Hum Pathol. 2003 Jan;34(1):54-64 [12605367.001]
  • [Cites] N Engl J Med. 2003 Oct 30;349(18):1722-9 [14585940.001]
  • [Cites] Cancer. 1973 Mar;31(3):600-5 [4693587.001]
  • [Cites] Nihon Gan Chiryo Gakkai Shi. 1979 Dec 20;14(7):1127-35 [541539.001]
  • [Cites] Br J Surg. 1988 Sep;75(9):873-4 [3179662.001]
  • [Cites] J Chin Med Assoc. 2005 Feb;68(2):87-91 [15759821.001]
  • [Cites] Br J Surg. 2005 Nov;92(11):1345-53 [16237743.001]
  • [Cites] Br J Surg. 2007 May;94(5):566-70 [17380564.001]
  • [Cites] J Endocrinol Invest. 2001 Jan;24(1):42-4 [11227731.001]
  • (PMID = 19491068.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] ENG
  • [Grant] United States / NINR NIH HHS / NR / NR008545-06; United States / NINR NIH HHS / NR / R56 NR008545; United States / NINR NIH HHS / NR / R56 NR008545-06
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS217054; NLM/ PMC2917245
  •  go-up   go-down


64. Bharadwaj R, Nema SK, Pujahari AK, Patkar N: Parathyroid adenoma with ectopic intrathymic parathyroid--a case report. Indian J Pathol Microbiol; 2005 Jan;48(1):37-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid adenoma with ectopic intrathymic parathyroid--a case report.
  • Relevant investigations suggested a parathyroid adenoma.
  • The adenoma was excised along with a suprasternal swelling.
  • Histopathological examination confirmed the parathyroid adenoma of the mixed chief and oxyphil type.
  • An incidental finding of an intrathymic parathyroid was also made.
  • They are also subject to functional activity and hence necessitate removal by the surgeon at the first sitting, having detected these abnormally located parathyroid tissues.
  • [MeSH-major] Adenoma / pathology. Mediastinal Neoplasms / pathology. Parathyroid Glands / pathology. Parathyroid Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16758787.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


65. Raghay K, García-Caballero T, Nogueiras R, Morel G, Beiras A, Diéguez C, Gallego R: Ghrelin localization in rat and human thyroid and parathyroid glands and tumours. Histochem Cell Biol; 2006 Mar;125(3):239-46
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ghrelin localization in rat and human thyroid and parathyroid glands and tumours.
  • In the current study, we use molecular biology to detect ghrelin transcripts expression in rats, and immunohistochemical techniques to investigate the cellular distribution of this peptide in rat and human thyroid and parathyroid glands and tumours.
  • Ghrelin was localized in thyroid C cells and in parathyroid cells.
  • Thyroid carcinomas (medullar, follicular and papillary) and parathyroid adenomas also showed intense and diffuse immunostaining for ghrelin.
  • The diffuse ghrelin immunostaining found in the parathyroid gland opens up the possibility of its secretion to the bloodstream or its involvement in the regulation of the parathyroid function.
  • Overall, expression of ghrelin in human and rat thyroid and parathyroid glands is highly suggestive of a conserved role of this molecule in the regulation of thyroid and parathyroid cell function.
  • [MeSH-major] Parathyroid Glands / metabolism. Parathyroid Neoplasms / metabolism. Peptide Hormones / metabolism. Thyroid Gland / metabolism. Thyroid Neoplasms / metabolism

  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Clin Endocrinol Metab. 2003 Feb;88(2):879-87 [12574228.001]
  • [Cites] J Endocrinol. 2002 Oct;175(1):201-9 [12379504.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Feb;86(2):881-7 [11158061.001]
  • [Cites] Biochim Biophys Acta. 2001 Nov 11;1522(1):62-5 [11718902.001]
  • [Cites] FEBS Lett. 2003 Feb 11;536(1-3):173-9 [12586359.001]
  • [Cites] Biochem Biophys Res Commun. 2001 Jan 26;280(3):904-7 [11162609.001]
  • [Cites] Life Sci. 2004 Sep 17;75(18):2193-201 [15325845.001]
  • [Cites] Am J Physiol Regul Integr Comp Physiol. 2001 May;280(5):R1483-7 [11294772.001]
  • [Cites] Neuroendocrinology. 2003 Feb;77(2):91-9 [12624530.001]
  • [Cites] Nature. 1999 Dec 9;402(6762):656-60 [10604470.001]
  • [Cites] Eur J Endocrinol. 2004 Aug;151(2):233-40 [15296479.001]
  • [Cites] J Endocrinol. 2002 Mar;172(3):R7-11 [11874717.001]
  • [Cites] Endocrinology. 2001 Sep;142(9):4154-7 [11517195.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Sep;86(9):4284-91 [11549663.001]
  • [Cites] Endocrinology. 2000 Nov;141(11):4255-61 [11089560.001]
  • [Cites] Eur J Endocrinol. 2002 Jul;147(1):159-63 [12088933.001]
  • [Cites] J Biol Chem. 2000 Jul 21;275(29):21995-2000 [10801861.001]
  • [Cites] Diabetes. 2002 Jan;51(1):124-9 [11756331.001]
  • [Cites] Biochem Biophys Res Commun. 2003 Sep 19;309(2):464-8 [12951072.001]
  • [Cites] Science. 1996 Aug 16;273(5277):974-7 [8688086.001]
  • [Cites] Circulation. 2001 Oct 23;104(17):2034-8 [11673342.001]
  • [Cites] Endocrinology. 2002 Feb;143(2):484-91 [11796502.001]
  • [Cites] J Clin Endocrinol Metab. 2001 Oct;86(10):4984-90 [11600575.001]
  • [Cites] Endocrinology. 2003 Apr;144(4):1594-602 [12639944.001]
  • [Cites] Am J Med Genet. 1995 Jan 2;55(1):33-7 [7702094.001]
  • [Cites] Endocrinology. 2002 Feb;143(2):717-25 [11796529.001]
  • [Cites] Endocrinology. 2000 Nov;141(11):4325-8 [11089570.001]
  • [Cites] Mol Endocrinol. 1997 Apr;11(4):415-23 [9092793.001]
  • [Cites] Neuron. 2003 Feb 20;37(4):649-61 [12597862.001]
  • [Cites] Endocrinology. 2001 Feb;142(2):788-94 [11159851.001]
  • [Cites] J Biol Chem. 2002 Feb 15;277(7):5667-74 [11724768.001]
  • [Cites] FEBS Lett. 2000 Dec 15;486(3):213-6 [11119706.001]
  • [Cites] J Endocrinol. 2000 Apr;165(1):139-46 [10750044.001]
  • [Cites] Biochem Biophys Res Commun. 2001 Nov 9;288(4):780-5 [11688975.001]
  • [Cites] J Clin Endocrinol Metab. 2003 Feb;88(2):853-7 [12574224.001]
  • [Cites] Biochem Biophys Res Commun. 2000 Oct 5;276(3):905-8 [11027567.001]
  • [Cites] Am J Pathol. 2003 Feb;162(2):645-54 [12547722.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Jun;87(6):2988 [12050285.001]
  • [Cites] Endocrinology. 2001 Oct;142(10):4163-9 [11564668.001]
  • [Cites] Endocrinology. 2003 Nov;144(11):5089-97 [12959995.001]
  • [Cites] J Clin Endocrinol Metab. 2002 Mar;87(3):1300-8 [11889202.001]
  • (PMID = 16187069.001).
  • [ISSN] 0948-6143
  • [Journal-full-title] Histochemistry and cell biology
  • [ISO-abbreviation] Histochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Ghrelin; 0 / Peptide Hormones; 0 / RNA, Messenger
  •  go-up   go-down


66. Hamidi S, Aslani A: Correlations between parathyroid adenoma weight and biochemical values. World J Surg; 2006 Dec;30(12):2299; author reply 2299-300
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlations between parathyroid adenoma weight and biochemical values.
  • [MeSH-major] Adenoma / blood. Adenoma / pathology. Parathyroid Neoplasms / blood. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Humans. Hyperparathyroidism / blood. Hyperparathyroidism / pathology. Organ Size

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentOn] World J Surg. 2006 Mar;30(3):321-6 [16467981.001]
  • [Cites] World J Surg. 2006 Mar;30(3):321-6 [16467981.001]
  • [Cites] ANZ J Surg. 2006 Oct;76(10):882-5 [17007616.001]
  • (PMID = 17103097.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  •  go-up   go-down


67. Târcoveanu E, Moldovanu R, Georgescu S, Niculescu D, Lupaşcu C, Dimofte G: [Pancreatic endocrine tumors]. Chirurgia (Bucur); 2006 Mar-Apr;101(2):175-81
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the four cases of insulinoma (all females) the diagnosis was delayed by two to five years due to misinterpretation of neurological symptoms generated by hypoglycemia.
  • The diagnosis of insulinoma was based on Whipple triad, high plasma insulin levels associated with low plasma glucose levels, as well as the symptomatic relief after intravenous glucose injection.
  • The diagnosis was confirmed on pathological examination in all cases.
  • Both patients died and diagnosis of pancreatic endocrine tumors was post-mortem.
  • The two patients with Wermer syndrome also had ulcers complicated with haemorrhage and peritonitis and parathyroid adenoma.
  • One case also had ante-hypophyseal and pituitary adenoma and the other had thyroid colloid hypertrophy.
  • [MeSH-major] Gastrinoma / diagnosis. Insulinoma / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Medical Records. Middle Aged. Multiple Endocrine Neoplasia Type 1 / diagnosis. Pancreatectomy. Retrospective Studies. Romania. Splenectomy. Survival Analysis. Zollinger-Ellison Syndrome / diagnosis

  • MedlinePlus Health Information. consumer health - Pancreatic Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16752684.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down


68. Bhansali A, Masoodi SR, Bhadada S, Mittal BR, Behra A, Singh P: Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgery. Clin Endocrinol (Oxf); 2006 Sep;65(3):340-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasonography in detection of single and multiple abnormal parathyroid glands in primary hyperparathyroidism: comparison with radionuclide scintigraphy and surgery.
  • BACKGROUND: Among the parathyroid imaging techniques, ultrasonography (USG) has the advantage of convenience, easy availability and low cost.
  • OBJECTIVE: To study the role of USG in localization (side and/or site) of abnormal parathyroid glands in primary hyperparathyroidism (PHPT) and to compare with radionuclide scintigraphy and the 'gold standard', surgery.
  • METHODS: Forty-six consecutive patients undergoing USG of the anterior neck for a diagnosis of PHPT in whom a nuclear scan (technetium-99m sestamibi and/or thallium-201/technetium-99m pertechnetate scintigraphy) was also performed, were studied.
  • RESULTS: Forty-six patients had 52 abnormal parathyroid glands on surgical exploration and surgery was successful in all but one.
  • Forty-one patients had a single adenoma, four had multigland disease and one had a paraganglioma.
  • USG correctly localized the abnormal gland in 30 (73%) and scintigraphy was positive in 40 (98%) out of 41 patients with a single adenoma as confirmed on surgical exploration.
  • Scintigraphy showed a positive concordant test in all 30 patients with a single abnormal gland detected on USG and picked up 10 out of 11 abnormal glands where USG was negative.
  • The sensitivity and positive predictive value of USG for detecting a single abnormal gland was 73% and 100%, respectively, whereas the sensitivity and positive predictive value for scintigraphy was 98%.
  • In patients with multigland disease, USG missed 3 (30%) out of 10 and scintigraphy missed 6 (60%) out of 10 abnormal parathyroid glands as confirmed on surgical exploration (P < 0.05).
  • However, in two patients who had ectopic parathyroid gland, both the modalities localized the lesion in one (paraganglioma), whereas in the other neither test was helpful (left retro-esophageal).
  • CONCLUSION: USG is a convenient, affordable and useful modality to localize abnormal enlarged parathyroid glands in the majority of patients with PHPT.
  • [MeSH-major] Hyperparathyroidism, Primary / ultrasonography. Parathyroid Glands / ultrasonography
  • [MeSH-minor] Adenoma / radionuclide imaging. Adenoma / surgery. Adenoma / ultrasonography. Adolescent. Adult. Female. Humans. Male. Middle Aged. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / surgery. Parathyroid Neoplasms / ultrasonography. Prospective Studies. Radioisotopes. Sensitivity and Specificity. Statistics, Nonparametric. Technetium Tc 99m Sestamibi. Thallium Radioisotopes

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16918953.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radioisotopes; 0 / Thallium Radioisotopes; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


69. Klein RD, Salih S, Bessoni J, Bale AE: Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory. Genet Med; 2005 Feb;7(2):131-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thirty-nine of 56 pedigrees with parathyroid and pancreatic islet neoplasia tested positive, compared with 4/24 and 8/32 pedigrees affected with hyperparathyroidism or hyperparathyroidism and pituitary tumors.
  • MEN1 mutations were found in 6/20 sporadic patients, all of whom had both parathyroid and pancreatic neoplasms.
  • Of 14 mutation-negative sporadic patients, 10 exhibited hyperparathyroidism and pituitary tumors without islet cell neoplasia.
  • CONCLUSION: Patients from pedigrees with hyperparathyroidism and pancreatic islet tumors are most likely to test positive for MEN1 mutations.
  • Mutations are less often detected in patients from pedigrees with hyperparathyroidism alone or in combination with pituitary tumors without pancreatic islet neoplasia.
  • [MeSH-major] Multiple Endocrine Neoplasia Type 1 / diagnosis. Multiple Endocrine Neoplasia Type 1 / genetics. Proto-Oncogene Proteins / genetics
  • [MeSH-minor] Adenoma, Islet Cell / etiology. Adenoma, Islet Cell / genetics. DNA Mutational Analysis. Genes, Tumor Suppressor. Humans. Hyperparathyroidism / etiology. Hyperparathyroidism / genetics. Pancreatic Neoplasms / etiology. Pancreatic Neoplasms / genetics. Pedigree. Phenotype. Polymerase Chain Reaction

  • Genetic Alliance. consumer health - Multiple Endocrine Neoplasia.
  • Genetic Alliance. consumer health - Multiple endocrine neoplasia type 1.
  • COS Scholar Universe. author profiles.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15714081.001).
  • [ISSN] 1098-3600
  • [Journal-full-title] Genetics in medicine : official journal of the American College of Medical Genetics
  • [ISO-abbreviation] Genet. Med.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM66079; United States / NIGMS NIH HHS / GM / T32 GM08753
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MEN1 protein, human; 0 / Proto-Oncogene Proteins
  •  go-up   go-down


70. Erbil Y, Kapran Y, Işsever H, Barbaros U, Adalet I, Dizdaroğlu F, Bozbora A, Ozarmağan S, Tezelman S: The positive effect of adenoma weight and oxyphil cell content on preoperative localization with 99mTc-sestamibi scanning for primary hyperparathyroidism. Am J Surg; 2008 Jan;195(1):34-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The positive effect of adenoma weight and oxyphil cell content on preoperative localization with 99mTc-sestamibi scanning for primary hyperparathyroidism.
  • BACKGROUND: Although the sensitivity of sestamibi scanning (MIBI) is high in patients with solitary parathyroid adenomas, negative sestamibi scan results are inevitable.
  • The exact mechanism of visualization of abnormal and hyperfunctioning parathyroid tissue is not yet clear.
  • The aims of this clinical study were (1) to evaluate positive and negative sestamibi scan results with regard to adenoma weight and oxyphil cell content and (2) to compare the effects of adenoma weight and oxyphil cell content on the results of sestamibi scanning.
  • Parathyroid adenoma weight and oxyphil cell content were determined in all patients.
  • RESULTS: The weight and oxyphil cell content of the parathyroid adenomas in the patients of group 1 were significantly higher than those in the patients of group 2 (P = .001).
  • An adenoma weight >600 mg and an oxyphil cell content >20% increased the rate of obtaining a positive sestamibi scan result 10- and 4-fold, respectively.
  • CONCLUSIONS: Both adenoma weight and oxyphil cell content were found to significantly correlate with positive sestamibi scan results.
  • In patients with high-weight adenomas, adenoma weight was the most significant factor in obtaining positive MIBI scan results, whereas in patients with low adenoma weights, high oxyphil cell content was the most significant factor in obtaining positive MIBI scan results.
  • [MeSH-major] Hyperparathyroidism, Primary / pathology. Hyperparathyroidism, Primary / radionuclide imaging. Oxyphil Cells / pathology. Parathyroid Neoplasms / pathology

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18082541.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


71. Beggs AD, Hain SF: Localization of parathyroid adenomas using 11C-methionine positron emission tomography. Nucl Med Commun; 2005 Feb;26(2):133-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Localization of parathyroid adenomas using 11C-methionine positron emission tomography.
  • BACKGROUND AND AIM: In symptomatic hyperparathyroidism, pre-surgical localization of the suspected site of adenoma is desirable.
  • The aim of this study was to determine whether 11C-methionine positron emission tomography (PET) could accurately localize parathyroid adenomas in patients in whom conventional imaging had failed.
  • PATIENTS AND METHODS: Fifty-one patients presenting with hyperparathyroidism, and in whom other imaging techniques had failed to definitely identify the site of adenoma, were reviewed retrospectively after 11C-methionine PET scanning.
  • RESULTS: 11C-Methionine PET scanning was found to have a sensitivity of 83%, a specificity of 100% and an accuracy of 88% in successfully locating parathyroid adenomas.
  • Most false negatives were due to adenomas in the lower mediastinum that was outside the area of scanning.
  • CONCLUSIONS: 11C-Methionine PET is a reliable and highly accurate technique for localizing parathyroid adenomas in patients in whom conventional imaging techniques have failed.
  • [MeSH-major] Adenoma / radionuclide imaging. Hyperthyroidism / radionuclide imaging. Methionine. Parathyroid Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods

  • MedlinePlus Health Information. consumer health - Hyperthyroidism.
  • Hazardous Substances Data Bank. (L)-Methionine .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15657506.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Validation Studies
  • [Publication-country] England
  • [Chemical-registry-number] 58576-49-1 / carbon-11 methionine; AE28F7PNPL / Methionine
  •  go-up   go-down


72. Yener S, Saklamaz A, Demir T, Kebapcilar L, Bayraktar F, Canda S, Yesil S: Primary hyperparathyroidism due to atypical parathyroid adenoma presenting with peroneus brevis tendon rupture. J Endocrinol Invest; 2007 May;30(5):442-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary hyperparathyroidism due to atypical parathyroid adenoma presenting with peroneus brevis tendon rupture.
  • [MeSH-major] Adenoma / complications. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Tendon Injuries / etiology

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Br Heart J. 1985 Nov;54(5):539-42 [2932135.001]
  • [Cites] Am J Med. 1993 Aug;95(2):197-202 [8356983.001]
  • [Cites] JAMA. 1972 Jul 24;221(4):406-7 [5067852.001]
  • [Cites] J Bone Miner Res. 1991 Oct;6 Suppl 2:S85-9; discussion S121-4 [1662460.001]
  • [Cites] Orthopedics. 1999 Dec;22(12):1177-9 [10604812.001]
  • [Cites] Ann Intern Med. 1974 Feb;80(2):182-93 [4811792.001]
  • [Cites] Ann Emerg Med. 1989 Jul;18(7):783-4 [2735601.001]
  • [Cites] J Foot Ankle Surg. 1999 Sep-Oct;38(5):359-62 [10553550.001]
  • [Cites] Rev Fac Cien Med Univ Nac Cordoba. 2004;61(1):37-9 [15366234.001]
  • [Cites] Hum Pathol. 2003 Jan;34(1):54-64 [12605367.001]
  • [Cites] World J Surg. 2000 Jan;24(1):102-7 [10594212.001]
  • [Cites] J Bone Miner Res. 1989 Jun;4(3):283-91 [2763869.001]
  • [Cites] Br J Radiol. 1983 Dec;56(672):915-20 [6652412.001]
  • (PMID = 17598980.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Italy
  •  go-up   go-down


73. Mahoney EJ, Monchik JM, Donatini G, De Lellis R: Life-threatening hypercalcemia from a hepatocellular carcinoma secreting intact parathyroid hormone: localization by sestamibi single-photon emission computed tomographic imaging. Endocr Pract; 2006 May-Jun;12(3):302-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Life-threatening hypercalcemia from a hepatocellular carcinoma secreting intact parathyroid hormone: localization by sestamibi single-photon emission computed tomographic imaging.
  • OBJECTIVE: To describe a patient with severe hypercalcemia and elevated intact parathyroid hormone (iPTH) levels associated with a hepatocellular carcinoma.
  • Findings on preoperative sestamibi scanning were suggestive of a parathyroid adenoma, with additional uptake in the dome of the liver.
  • He was diagnosed as having primary hyperparathyroidism, and a neck exploration was undertaken.
  • The right superior, right inferior, and left superior parathyroid glands were mildly enlarged and were excised.
  • The left inferior parathyroid gland could not be identified, despite an extensive neck exploration.
  • [MeSH-major] Carcinoma, Hepatocellular / secretion. Hypercalcemia / complications. Hypercalcemia / etiology. Liver Neoplasms / secretion. Parathyroid Hormone / blood
  • [MeSH-minor] Aged. Chemoembolization, Therapeutic. Fatal Outcome. Hormones, Ectopic / blood. Humans. Hyperparathyroidism / etiology. Male. Parathyroid Glands / surgery. Recurrence. Technetium Tc 99m Sestamibi. Tomography, Emission-Computed

  • Genetic Alliance. consumer health - Parathyroid carcinoma.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16772205.001).
  • [ISSN] 1530-891X
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hormones, Ectopic; 0 / Parathyroid Hormone; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


74. Juhlin CC, Villablanca A, Sandelin K, Haglund F, Nordenström J, Forsberg L, Bränström R, Obara T, Arnold A, Larsson C, Höög A: Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification. Endocr Relat Cancer; 2007 Jun;14(2):501-12
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification.
  • Parafibromin is a protein product derived from the hyperparathyroidism 2(HRPT2) tumor suppressor geneand its inactivation has been coupled to familial and sporadic forms of parathyroid malignancy.
  • In this study, we have conducted immunohistochemistry on 33 parathyroid carcinomas (22 unequivocal and 11 equivocal) using four parafibromin antibodies directed to different parts of the protein.
  • Our findings show that 68% (15 out of 22) of the unequivocal carcinomas exhibited reduced expression of parafibromin while the 25 sporadic adenomas used as controls were entirely positive for parafibromin expression.
  • We conclude that parafibromin immunohistochemistry could be used as an additional marker for parathyroid tumor classification, where positive samples have low risk of malignancy, whereas samples with reduced expression could be either carcinomas or rare cases of adenomas likely carrying an HRPT2 mutation.
  • [MeSH-major] Adenoma / classification. Adenoma / diagnosis. Biomarkers, Tumor / analysis. Carcinoma / classification. Carcinoma / diagnosis. Parathyroid Neoplasms / classification. Parathyroid Neoplasms / diagnosis. Tumor Suppressor Proteins / analysis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17639063.001).
  • [ISSN] 1351-0088
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers, Tumor; 0 / CDC73 protein, human; 0 / Tumor Suppressor Proteins
  •  go-up   go-down


75. Aziz MM, Khan AW, Uddin MF, Hasanat MA, Kader MA, Chowdhury AJ, Choudhury NA: Endoscopic para-thyroidectomy: a new approach. Mymensingh Med J; 2010 Jul;19(3):442-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two patients (one male and one female) underwent endoscopic para-thyroidectomy for parathyroid adenoma at the Department of Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
  • Both patient's parathyroid hormone (PTH) level dropped to about one fourth the level in 12 to 20 minutes after enucleation (as compared to the immediate pre operative level).

  • MedlinePlus Health Information. consumer health - Endoscopy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20639842.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
  •  go-up   go-down


76. Weber T, Cammerer G, Schick C, Solbach C, Hillenbrand A, Barth TF, Henne-Bruns D, Blagieva R, Böhm BO, Reske SN, Luster M: C-11 methionine positron emission tomography/computed tomography localizes parathyroid adenomas in primary hyperparathyroidism. Horm Metab Res; 2010 Mar;42(3):209-14
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] C-11 methionine positron emission tomography/computed tomography localizes parathyroid adenomas in primary hyperparathyroidism.
  • In patients with primary hyperparathyroidism (pHPT), positive preoperative localization studies enable to perform a minimally invasive approach for parathyroid surgery.
  • We therefore conducted a study to determine the sensitivity of C-11 methionine positron emission tomography/computed tomography (Met-PET/CT) in localizing parathyroid adenomas in pHPT.
  • Met-PET/CT scans of the neck and mediastinum of 33 patients undergoing parathyroidectomy for primary HPT were compared with intraoperative and histological findings.
  • Primary HPT was caused by a single gland adenoma in 30 patients, while another 3 patients had multiglandular disease.
  • Met-PET/CT scan correctly located a single gland adenoma in 25 out of 30 (83%) patients with pHPT, among them 2 patients with persistent disease, 7 patients with prior neck surgery, and 8 patients with concomitant thyroid nodules.
  • In 3 patients with multiglandular disease, Met-PET/CT showed only one enlarged parathyroid gland in two individuals and was negative in the third patient.
  • Statistical analysis found a significant correlation between true-positive results and the weight (2.42+/-4.05 g) and diameter (2.0+/-1.18 cm) of parathyroid adenomas while the subgroup with false negative findings had significantly smaller (0.98+/-0.54 cm) and lighter (0.5+/-0.38 g) glands.
  • Sensitivity was 83% for single gland adenomas and 67% for multiglandular disease.
  • Met-PET/CT correctly localized 83% of single gland parathyroid adenomas in patients with pHPT.
  • However, preoperative localization of multiglandular disease due to double adenomas or parathyroid hyperplasia remained difficult.
  • [MeSH-major] Adenoma / radionuclide imaging. Hyperparathyroidism, Primary / radionuclide imaging. Methionine. Parathyroid Neoplasms / radionuclide imaging. Positron-Emission Tomography. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • Hazardous Substances Data Bank. (L)-Methionine .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20013649.001).
  • [ISSN] 1439-4286
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 58576-49-1 / carbon-11 methionine; AE28F7PNPL / Methionine
  •  go-up   go-down


77. Ikeda Y, Takayama J, Takami H: Minimally invasive radioguided parathyroidectomy for hyperparathyroidism. Ann Nucl Med; 2010 May;24(4):233-40
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive radioguided parathyroidectomy for hyperparathyroidism.
  • Clinical or subclinical hyperparathyroidism (HPT) is one of the most common endocrine disorders.
  • In patients with HPT who meet the indications for parathyroidectomy, complete surgical resection of all hyperfunctioning parathyroid tissue is essential for the curative treatment.
  • The conventional surgical approach is bilateral neck exploration, whereas minimally invasive parathyroidectomy has been made possible by the introduction of (99m)Tc-sestamibi scintigraphy for preoperative localization of parathyroid adenomas.
  • In minimally invasive surgery, the surgeon expects some modalities that predict complete resection of all hyperfunctioning parathyroid glands.
  • The prevalence rate of (99m)Tc-sestamibi scanning for single parathyroid adenoma was widely accepted as 85-95%.
  • Intraoperative navigation using these devices provides the possibility of easy and definitive identification of parathyroid nodules during the operation.
  • [MeSH-major] Hyperparathyroidism / surgery. Minimally Invasive Surgical Procedures / methods. Parathyroidectomy / methods. Surgery, Computer-Assisted / methods
  • [MeSH-minor] Humans. Intraoperative Period. Parathyroid Hormone / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20333484.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  • [Number-of-references] 45
  •  go-up   go-down


78. Triantafillidou K, Zouloumis L, Karakinaris G, Kalimeras E, Iordanidis F: Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature. Am J Otolaryngol; 2006 Jul-Aug;27(4):281-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature.
  • PURPOSE: The aim of this article is to present the development of brown tumors in the jaws as a definite feature of hyperparathyroidism (HPT), whether primary or secondary.
  • PATIENTS AND METHODS: The study included 2 cases of primary HPT and 3 cases of secondary HPT associated with brown tumors in the jaws.
  • The surgical excision of bone lesions and treatment of primary or secondary HPT were performed on the patients in our study.
  • RESULTS: Patient 1 (primary HPT, caused by an adenoma of the right parathyroid glands) was treated with surgical removal of the maxillary lesion and excision of the adenoma.
  • Patient 2 (primary HPT, caused by an adenoma of the right parathyroid glands) was treated with excision of the adenoma.
  • One year later, a second bone lesion developed in the mandible, and 3(1/2) of the fourth parathyroid (right) glands was removed.
  • CONCLUSIONS: Primary or secondary HPT may be recognized by the presence of an osteolytic lesion with giant cells, a condition referred as "brown tumor."
  • The most useful therapy for patients with brown tumors is surgical excision of bone lesions and therapy (surgical or medical) for primary or secondary HPT.
  • [MeSH-major] Hyperparathyroidism / complications. Jaw Diseases / etiology. Osteitis Fibrosa Cystica / etiology. Osteolysis / etiology

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - Jaw Injuries and Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16798410.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
  •  go-up   go-down


79. Balasanthiran A, Sandler B, Amonoo-Kuofi K, Swamy R, Kaniyur S, Kaplan F: Sarcoid granulomas in the parathyroid gland - a case of dual pathology: hypercalcaemia due to a parathyroid adenoma and coexistent sarcoidosis with granulomas located within the parathyroid adenoma and thyroid gland. Endocr J; 2010;57(7):603-7
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sarcoid granulomas in the parathyroid gland - a case of dual pathology: hypercalcaemia due to a parathyroid adenoma and coexistent sarcoidosis with granulomas located within the parathyroid adenoma and thyroid gland.
  • We present a highly unusual and interesting case of coexistent hyperparathyroidism and sarcoidosis leading to hypercalcaemia.
  • Parathyroid imaging was then requested and an adenoma was identified.
  • Surprisingly, surgery revealed the coexistence of a parathyroid adenoma with the unexpected finding of sarcoid granulomas within the parathyroid and thyroid glands.
  • [MeSH-major] Adenoma / complications. Granuloma / complications. Hypercalcemia / etiology. Parathyroid Diseases / complications. Parathyroid Neoplasms / complications. Sarcoidosis / complications. Thyroid Neoplasms / complications
  • [MeSH-minor] Aged. Female. Humans. Neoplasms, Multiple Primary / complications. Neoplasms, Multiple Primary / surgery. Parathyroid Glands / pathology. Parathyroid Glands / surgery. Parathyroidectomy. Thyroid Gland / pathology


80. Ismail M, Maza S, Swierzy M, Tsilimparis N, Rogalla P, Sandrock D, Rückert RI, Müller JM, Rückert JC: Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic system. Br J Surg; 2010 Mar;97(3):337-43
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection of ectopic mediastinal parathyroid glands with the da Vinci robotic system.
  • BACKGROUND: Mediastinal ectopic parathyroid adenoma is a frequent cause of persistent or recurrent hyperparathyroidism, traditionally treated by open surgery.
  • The aim of this study was to evaluate the feasibility and effectiveness of robot-assisted dissection for mediastinal ectopic parathyroid glands.
  • METHODS: Two patients with recurrent secondary hyperparathyroidism and three with complicated primary hyperparathyroidism were operated on between July 2004 and August 2008 for ectopic mediastinal parathyroid glands.
  • Intraoperative parathyroid hormone reduction indicated complete resection.
  • CONCLUSION: Robot-assisted dissection is a promising approach for resection of ectopic parathyroid glands in remote narrow anatomical locations such as the mediastinum.
  • [MeSH-major] Adenoma / surgery. Mediastinal Neoplasms / surgery. Parathyroid Glands / surgery. Parathyroid Neoplasms / surgery. Robotics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 20095017.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  •  go-up   go-down


81. Díaz-Aguirregoitia FJ, De la Quintana A, Rodeño Esteban I, Lamiquiz Vallejo A, Gaztambide Saenz S, Pérdigo LF, Mujica J, Echenique Elizondo M: [Modifications in intact parathyroid hormone, total serum calcium, and ionized calcium levels in the surgery of primary hyperparathyroidism for single adenoma]. Cir Esp; 2006 Nov;80(5):301-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Modifications in intact parathyroid hormone, total serum calcium, and ionized calcium levels in the surgery of primary hyperparathyroidism for single adenoma].
  • [Transliterated title] Modificaciones de paratirina intacta, calcio sérico total y calcio ionizado en la cirugía por hiperparatiroidismo primario por adenoma único.
  • INTRODUCTION: We evaluated total serum calcium (TSC) and ionized calcium (IC) and their correlation with intraoperative intact parathyroid hormone (iPTH) in the surgery of primary hyperparathyroidism in patients with a single adenoma.
  • MATERIAL AND METHOD: We performed a prospective, blind trial with determination of iPHT, TSC and IC in a cohort of surgical patients (n = 279; 244 were valid for the study) who underwent surgery in the Department of Surgery, Hospital de Cruces, between October 1999 and April 2006.
  • Frozen samples were conclusive for parathyroid tissue (19.56 +/- 15.3 after excision).
  • CONCLUSIONS: Intraoperative total calcium levels may help to predict adequate elimination of parathyroid tissue in primary hyperparathyroidism when intraoperative iPTH is not available.
  • [MeSH-major] Adenoma / surgery. Hyperparathyroidism, Primary / surgery. Intraoperative Care. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods
  • [MeSH-minor] Calcium / blood. Female. Humans. Male. Middle Aged. Parathyroid Hormone / blood

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17192206.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Parathyroid Hormone; SY7Q814VUP / Calcium
  •  go-up   go-down


82. Costanzo M, Terminella A, Marziani A, Chisari A, Missiato A, Cannizzaro MA: Giant mediastinal parathyroid adenoma: a case report. Ann Ital Chir; 2009 Jan-Feb;80(1):55-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mediastinal parathyroid adenoma: a case report.
  • Neck and chest TC and 'TC sestamibi scintigraphy showed the presence of a 7 cm hyperfunctional ectopic parathyroid tissue in the postero-superior mediastinum infiltrating oesophagus.
  • Through right postero-lateral thoracotomy and mediastinal pleura incision, the adenoma excision was carried out.
  • The histological examination revealed a potentially malignant parathyroid adenoma with infiltration, without over-reaching the capsule.
  • Today, the tendency to minimally invasive surgery, an accurate preoperative localization of the adenoma and the use of techniques such as intra-surgical nuclear mapping through manual gamma probes, selective angiography, venous intraoperative dosage of PTH and intra-surgical ultrasound scan.
  • [MeSH-major] Adenocarcinoma / pathology. Choristoma / pathology. Mediastinum / pathology. Parathyroid Glands. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Adenoma / pathology. Aged. Female. Humans. Parathyroidectomy. Radiopharmaceuticals. Technetium Tc 99m Sestamibi. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19537125.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


83. Richard B: [Primary hyperparathyroidism: ultrasonography and scintigraphy]. J Radiol; 2009 Mar;90(3 Pt 2):397-408
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary hyperparathyroidism: ultrasonography and scintigraphy].
  • Primary hyperparathyroidism is nowadays frequently diagnosed from screening biological work-up: it is due to a single parathyroid adenoma in nearly 90% of cases.
  • Ultrasound offers detailed anatomic imaging of the adenoma but may not be not able to detect some ectopic glands.
  • Radionuclide scanning using Tc-99m-Sestamibi is able to localize parathyroid adenomas even in the case of ectopic localization with the help of SPECT-CT.
  • [MeSH-major] Adenoma / radionuclide imaging. Adenoma / ultrasonography. Hyperparathyroidism, Primary / radionuclide imaging. Hyperparathyroidism, Primary / ultrasonography. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / ultrasonography. Radionuclide Imaging / methods. Ultrasonography / methods

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - Nuclear Scans.
  • MedlinePlus Health Information. consumer health - Ultrasound.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19421130.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  • [Number-of-references] 4
  •  go-up   go-down


84. Altinova AE, Toruner F, Cimen AR, Karakoc A, Atasever T, Yetkin I, Ayvaz G, Cakir N, Arslan M: The association of neurofibromatosis, bilateral pheochromocytoma and primary hyperparathyroidism. Exp Clin Endocrinol Diabetes; 2007 Jul;115(7):468-70
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The association of neurofibromatosis, bilateral pheochromocytoma and primary hyperparathyroidism.
  • Pheochromocytoma or hyperparathyroidism have been reported to be associated with NF type 1 (NF1).
  • However, the coexistance of pheochromocytoma and parathyroid adenoma in a patient with NF1 is very rare.
  • We report a case of a 37-year-old male with NF1, bilateral pheochromocytoma and parathyroid adenoma.
  • [MeSH-major] Adrenal Gland Neoplasms / complications. Hyperparathyroidism, Primary / complications. Neurofibromatoses / complications. Pheochromocytoma / complications
  • [MeSH-minor] Adenoma / complications. Adult. Humans. Male. Parathyroid Neoplasms / complications


85. Carchman E, Ogilvie J, Holst J, Yim J, Carty S: Appropriate surgical treatment of lithium-associated hyperparathyroidism. World J Surg; 2008 Oct;32(10):2195-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appropriate surgical treatment of lithium-associated hyperparathyroidism.
  • Although lithium-associated hyperparathyroidism (LAH) is well documented, reports concerning its pathologic findings are sparse.
  • METHODS: From 1995 to 2007, data from 1207 consecutive patients who underwent concise parathyroid exploration for sporadic primary hyperparathyroidism (PHP) directed by quick intraoperative parathyroid hormone monitoring (QPTH) were reviewed to identify patients with LAH.
  • Among 16 patients with LAH, 12 (75%) had a single adenoma.
  • The use of QPTH allowed unilateral exploration in 8 of 12 patients with single adenoma.
  • Parathyroid exploration resulted in durable biochemical cure for all 16 patients with LAH.
  • CONCLUSION: Multiglandular disease seems to be no more frequent in patients with LAH than in patients with primary hyperparathyroidism (PHP) without LAH.
  • [MeSH-major] Antimanic Agents / adverse effects. Hyperparathyroidism / surgery. Lithium Compounds / adverse effects. Parathyroidectomy / methods
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / surgery. Bipolar Disorder / drug therapy. Female. Humans. Male. Middle Aged. Monitoring, Intraoperative / methods. Parathyroid Hormone / blood. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / surgery. Preoperative Care / methods. Prospective Studies. Recurrence. Retrospective Studies. Treatment Outcome

  • Hazardous Substances Data Bank. LITHIUM COMPOUNDS .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Surgery. 1997 Dec;122(6):1107-14; discussion 1114-6 [9426426.001]
  • [Cites] Ann Ital Chir. 2007 Mar-Apr;78(2):91-6 [17583117.001]
  • [Cites] Am J Kidney Dis. 2006 Nov;48(5):832-7 [17060004.001]
  • [Cites] Am J Med. 2002 Dec 1;113(8):681-4 [12505119.001]
  • [Cites] Br J Surg. 1999 Jan;86(1):91-3 [10027368.001]
  • [Cites] Metabolism. 1994 Dec;43(12):1563-7 [7990712.001]
  • [Cites] Surgery. 2005 Dec;138(6):1027-31; discussion 1031-2 [16360387.001]
  • [Cites] Ann Surg. 2004 Apr;239(4):528-35 [15024314.001]
  • [Cites] Am J Ther. 1997 Sep-Oct;4(9-10):323-5 [10423626.001]
  • [Cites] Proc (Bayl Univ Med Cent). 2002 Oct;15(4):363-5 [16333464.001]
  • [Cites] J Clin Endocrinol Metab. 1981 May;52(5):1046-8 [7228989.001]
  • [Cites] Surgery. 2002 Dec;132(6):1086-92; discussion 1092-3 [12490859.001]
  • [Cites] J Intern Med. 1996 Dec;240(6):357-65 [9010382.001]
  • [Cites] J Intern Med. 2005 Jan;257(1):27-37 [15606374.001]
  • [Cites] Med Lab Sci. 1987 Apr;44(2):115-8 [3695842.001]
  • [Cites] Endocr Pract. 2006 Jan-Feb;12(1):54-8 [16524864.001]
  • [Cites] World J Surg. 2003 Apr;27(4):486-8 [12658498.001]
  • [Cites] Lancet. 1977 Nov 26;2(8048):1129-30 [73034.001]
  • [Cites] Lancet. 1973 Aug 11;2(7824):331-2 [4124825.001]
  • [Cites] Conn Med. 1990 Nov;54(11):614-5 [2124533.001]
  • [Cites] Am J Surg. 2005 May;189(5):596-600; discussion 600 [15862503.001]
  • [Cites] Endocr Pract. 2001 Jul-Aug;7(4):323-5 [11497486.001]
  • [Cites] Ann Pharmacother. 1993 Sep;27(9):1040-3 [8219433.001]
  • [Cites] J Clin Endocrinol Metab. 1997 Sep;82(9):2844-8 [9284708.001]
  • [Cites] Lancet. 1976 Jul 17;2(7977):144 [59204.001]
  • [Cites] Acta Psychiatr Scand. 1982 Nov;66(5):361-73 [6817593.001]
  • [Cites] Surgery. 2006 Apr;139(4):527-34 [16627063.001]
  • [Cites] Surgery. 1991 Dec;110(6):1061-6 [1745976.001]
  • (PMID = 18463919.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimanic Agents; 0 / Lithium Compounds; 0 / Parathyroid Hormone
  •  go-up   go-down


86. Nwariaku FE, Snyder WH, Burkey SH, Watumull L, Mathews D: Inframanubrial parathyroid glands in patients with primary hyperparathyroidism: alternatives to sternotomy. World J Surg; 2005 Apr;29(4):491-4
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inframanubrial parathyroid glands in patients with primary hyperparathyroidism: alternatives to sternotomy.
  • Deep inframanubrial parathyroid tumors have traditionally been excised through a median sternotomy.
  • With the advent of minimally invasive surgical access, we chose to examine the treatment options and outcomes of patients with inframanubrial mediastinal parathyroid tumors.
  • Patients with primary hyperparathyroidism seen at a university medical center over a 12-year period were retrospectively reviewed.
  • The utility of localization studies, methods of treatment, complications, and outcomes were examined in patients with a parathyroid tumor located in the mediastinum inferior to the manubrium.
  • Patients with parathyroid adenomas located at the thoracic inlet were excluded.
  • Altogether, 81% of the patients had undergone at least one prior neck exploration for primary hyperparathyroidism.
  • Preoperative calcium and parathyroid hormone levels were 12.4 +/- 0.36 mg/dl and 273 +/- 70 pg/ml, respectively.
  • Localization studies identified mediastinal parathyroid adenomas in the following locations: anterior mediastinum (n = 8), middle mediastinum (n = 7), posterior mediastinum (n = 1).
  • Seven patients underwent successful excision of the mediastinal adenoma by transcervical mediastinal exploration with the Cooper retractor.
  • Most inframanubrial mediastinal parathyroid tumors can be successfully managed without median sternotomy.
  • [MeSH-major] Parathyroid Neoplasms / surgery. Sternum / surgery
  • [MeSH-minor] Adenoma / surgery. Adolescent. Adult. Aged. Calcium / blood. Female. Humans. Hyperparathyroidism / surgery. Magnetic Resonance Imaging. Male. Mediastinum. Middle Aged. Minimally Invasive Surgical Procedures. Parathyroid Hormone / blood. Radiopharmaceuticals. Retrospective Studies. Sensitivity and Specificity. Technetium Tc 99m Sestamibi. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Chir (Paris). 1988 Nov;125(11):631-7 [3066794.001]
  • [Cites] Surg Laparosc Endosc. 1995 Oct;5(5):402-6 [8845987.001]
  • [Cites] J Am Coll Surg. 1997 Nov;185(5):481-5 [9358094.001]
  • [Cites] Am Surg. 1983 Oct;49(10):523-7 [6678542.001]
  • [Cites] Am Surg. 1991 Jan;57(1):62-6 [1796800.001]
  • [Cites] Am J Med. 1994 Dec;97(6):529-34 [7985712.001]
  • [Cites] Radiology. 1975 Apr;115(1):37-42 [1118615.001]
  • [Cites] Am J Surg. 1984 Sep;148(3):402-3 [6476233.001]
  • [Cites] Ann Surg. 1991 Nov;214(5):555-61 [1953107.001]
  • [Cites] AJR Am J Roentgenol. 1999 Jul;173(1):94 [10397106.001]
  • [Cites] J Nucl Med. 1996 Sep;37(9):1535-7 [8790213.001]
  • [Cites] Semin Nucl Med. 1987 Jul;17 (3):278-9 [3039666.001]
  • [Cites] Radiology. 1975 Apr;115(1):31-6 [1118614.001]
  • [Cites] Biomed Pharmacother. 2002;56 Suppl 1:34s-36s [12487248.001]
  • [Cites] J Cardiovasc Surg (Torino). 2003 Feb;44(1):139-40 [12627087.001]
  • [Cites] Am Surg. 1995 Sep;61(9):796-8 [7661478.001]
  • [Cites] Ann Surg. 1976 Mar;183(3):271-5 [1259483.001]
  • [Cites] Surg Laparosc Endosc Percutan Tech. 2001 Dec;11(6):385-8 [11822866.001]
  • [Cites] Arch Surg. 1988 Sep;123(9):1096-100 [3415460.001]
  • (PMID = 15770373.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi; SY7Q814VUP / Calcium
  •  go-up   go-down


87. Ahmad S, Mufti TS, Khan AA, Ahmad S: Parathyroid carcinoma. J Ayub Med Coll Abbottabad; 2006 Apr-Jun;18(2):84-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parathyroid carcinoma.
  • Parathyroid carcinoma is a very rare cause of primary hyperparathyroidism and these tumors are usually hyper-functioning as compared to other malignant endocrine tumors.
  • Surgery is the only effective primary treatment.
  • Parathyroid adenoma was initially diagnosed and localized at left lower gland by Sestamibi scan and ultrasonography.
  • She underwent surgery and enlarged parathyroid gland was removed.
  • [MeSH-major] Adenoma / diagnosis. Parathyroid Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

  • Genetic Alliance. consumer health - Parathyroid carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16977824.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  •  go-up   go-down


88. Ostojić Z, Grle M, Moro G, Zubak Z, Ostojić M: Bone fractures in a 53-year-old patient with parathyroid adenoma--a case report. Coll Antropol; 2010 Mar;34 Suppl 1:295-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone fractures in a 53-year-old patient with parathyroid adenoma--a case report.
  • The study reports a case of primary hyperparathyroidism in a middle-aged patient who was first admitted for persistent ankle pain and local swelling.
  • The subsequent clinical procedures suggested cystic changes in several leg bones, which were later shown to be caused by the parathyroid adenoma.
  • Clinical presentation of the primary hyperparathyroidism can be highly misleading, sometimes causing various clinical procedures before it is certainly diagnosed.
  • [MeSH-major] Adenoma / complications. Femoral Fractures / etiology. Hyperparathyroidism, Primary / diagnosis. Parathyroid Neoplasms / complications. Tibial Fractures / etiology

  • MedlinePlus Health Information. consumer health - Leg Injuries and Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20402337.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
  •  go-up   go-down


89. Rubello D, Pelizzo MR, Boni G, Schiavo R, Vaggelli L, Villa G, Sandrucci S, Piotto A, Manca G, Marini P, Mariani G: Radioguided surgery of primary hyperparathyroidism using the low-dose 99mTc-sestamibi protocol: multiinstitutional experience from the Italian Study Group on Radioguided Surgery and Immunoscintigraphy (GISCRIS). J Nucl Med; 2005 Feb;46(2):220-6
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radioguided surgery of primary hyperparathyroidism using the low-dose 99mTc-sestamibi protocol: multiinstitutional experience from the Italian Study Group on Radioguided Surgery and Immunoscintigraphy (GISCRIS).
  • This study evaluated the accuracy of (99m)Tc-sestamibi scintigraphy and neck ultrasonography in patients with primary hyperparathyroidism (PHPT) and the role of intraoperative hand-held gamma-probes in minimally invasive radioguided surgery (MIRS) of patients with a high likelihood of a solitary parathyroid adenoma (PA).
  • Intraoperative quick parathyroid hormone (IQPTH) assay was used on 308 patients (80.2%).
  • Conversion to bilateral neck exploration was necessary in 9 patients (3.3%) because of either persistently high IQPTH levels after removal of the preoperatively visualized PA (4 patients), intraoperative frozen-section diagnosis of parathyroid carcinoma (2 patients), or hard-to-remove PA (3 patients).
  • MIRS was successfully performed also on 32 (78.0%) of 41 patients who had previously undergone thyroid or parathyroid surgery.
  • IQPTH measurement helped to disclose some cases of multigland parathyroid disease.
  • IQPTH can be recommended during MIRS to facilitate intraoperative identification of previously undiagnosed multigland parathyroid disease.
  • [MeSH-major] Hyperparathyroidism / radionuclide imaging. Hyperparathyroidism / surgery. Minimally Invasive Surgical Procedures / methods. Parathyroidectomy / methods. Surgery, Computer-Assisted / methods. Technetium Tc 99m Sestamibi
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Causality. Female. Humans. Italy / epidemiology. Male. Middle Aged. Postoperative Complications / diagnosis. Postoperative Complications / epidemiology. Radiopharmaceuticals. Treatment Outcome

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Nucl Med. 2005 Feb;46(2):198-9 [15695775.001]
  • (PMID = 15695779.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


90. Ohe MN, Santos RO, Kunii IS, Abrahão M, Cervantes O, Carvalho AB, Lazaretti-Castro M, Vieira JG: [Usefulness of intraoperative PTH measurement in primary and secondary hyperparathyroidism: experience with 109 patients]. Arq Bras Endocrinol Metabol; 2006 Oct;50(5):869-75
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Usefulness of intraoperative PTH measurement in primary and secondary hyperparathyroidism: experience with 109 patients].
  • [Transliterated title] Utilidade da medida de PTH intra-operatório no tratamento cirúrgico do hiperparatiroidismo primário e secundário: análise de 109 casos.
  • INTRODUCTION: Intraoperative parathyroid hormone measurement (IO-PTH) was first described in 1988 and it's potentially useful in predicting cure after parathyroidectomy.
  • The aim of this study was to evaluate IO-PTH decay profile and the utility of this procedure in predicting cure in primary (PHH) and secondary (SHH) hyperparathyroidism due to renal disease.
  • All patients were cured, except 2 (1 PHH, 1 SHH), because of a double adenoma and ectopic (mediastinal) parathyroid respectively.
  • [MeSH-major] Hyperparathyroidism, Primary / blood. Hyperparathyroidism, Secondary / blood. Monitoring, Intraoperative. Parathyroid Hormone / blood. Parathyroidectomy

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17160210.001).
  • [ISSN] 0004-2730
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


91. Giraldez-Rodriguez LA, Giraldez-Casasnovas LJ: Minimally invasive parathyroidectomy as treatment for primary hyperparathyroidism. Bol Asoc Med P R; 2008 Jan-Mar;100(1):27-32
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minimally invasive parathyroidectomy as treatment for primary hyperparathyroidism.
  • BACKGROUND: Current techniques for management of primary hyperpara-thyroidism (pHPT) rely on preoperative localization studies in order to perform a direct exploration of the neck.
  • This case series reports the results of minimally invasive parathyroidectomy (MIP) performed in twenty-two consecutive pHPT patients with suspected parathyroid adenoma.
  • METHODS: All patients with symptomatic pHPT and or aberrant biochemical markers underwent preoperative evaluation including calcium and parathyroid hormone (PTH) serum levels, and a Tc-99 Sestamibi (MIBI) scintigraphy scan.
  • The day of surgery Tc-99 MIBI was administered intravenously to localize diseased parathyroid glands.
  • All removed tissue was again tested with the gamma radiation probe and sent for frozen sections to confirm parathyroid gland tissue.
  • Parathyroid adenoma was confirmed by frozen sections in all patients.
  • CONCLUSIONS: MIP using preoperative Tc-99 MIBI scan is an excellent and safe treatment for patients in pHPT patients with a suspected parathyroid adenoma.
  • [MeSH-major] Hyperparathyroidism, Primary / surgery. Parathyroidectomy / methods

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18763394.001).
  • [ISSN] 0004-4849
  • [Journal-full-title] Boletín de la Asociación Médica de Puerto Rico
  • [ISO-abbreviation] Bol Asoc Med P R
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Puerto Rico
  •  go-up   go-down


92. Elisei R, Romei C, Cosci B, Agate L, Bottici V, Molinaro E, Sculli M, Miccoli P, Basolo F, Grasso L, Pacini F, Pinchera A: RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center. J Clin Endocrinol Metab; 2007 Dec;92(12):4725-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Three different syndromes are distinguished: MEN 2A, when medullary thyroid carcinoma (MTC) is associated with pheochromocytoma and/or parathyroid adenomas; MEN 2B, when accompanied by a marfanoid habitus and/or pheochromocytoma; and familial medullary thyroid carcinoma (FMTC), when only MTC is present.


93. Kammori M, Fukami T, Ogawa T, Tsuji E, Takubo K, Nakajima J, Kaminishi M: Image in endocrinology: giant mediastinal cystic parathyroid adenoma. J Clin Endocrinol Metab; 2006 May;91(5):1635-6
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image in endocrinology: giant mediastinal cystic parathyroid adenoma.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Parathyroid Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16679508.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


94. Iacobone M, Scarpa M, Lumachi F, Favia G: Are frozen sections useful and cost-effective in the era of intraoperative qPTH assays? Surgery; 2005 Dec;138(6):1159-64; discussion 1164-5
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Since intraoperative quick parathormone (IOqPTH) assays are available, the role of frozen sections (FS) during parathyroid exploration has become questionable.
  • This study compares the results of FS and IOqPTH in primary hyperparathyroidism (pHPT).
  • The operation was considered complete when both an IOqPTH drop >50% and a FS diagnosis of parathyroid adenoma were obtained.
  • FS correctly predicted the definitive histologic diagnosis with an accuracy of 81%.
  • [MeSH-major] Frozen Sections / economics. Hyperparathyroidism, Primary / blood. Hyperparathyroidism, Primary / pathology. Monitoring, Intraoperative / economics. Parathyroid Hormone / blood

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16360404.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone
  •  go-up   go-down


95. Sadeghi N, Akin E, Lee JY, Roland J, Knoll S: Targeted parathyroidectomy: effectiveness and intraoperative rapid-parathormone dynamics. Laryngoscope; 2008 Nov;118(11):1997-2002
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The objective of this study is to assess the effectiveness of selective parathyroid exploration, using preoperative image localization and intraoperative rapid-parathormone (rPTH) assay.
  • The kinetics of intraoperative rPTH in parathyroid adenoma vs. multiglandular disease is assessed.
  • DESIGN: This is a prospective noncontrolled study of a cohort of 100 patients with primary hyperparathyroidism, at a single academic institution.
  • Data were available in 96 cases: 87 single-gland adenoma with two in ectopic mediastinal position, two double adenoma and seven cases of hyperplasia.
  • Ten percent of patients with adenoma needed bilateral exploration for nonlocalizing or false negative imaging, or for intraoperative rPTH failure to decay.
  • CONCLUSION: Targeted parathyroidectomy, when appropriately selected and carried out, is an effective treatment of primary hyperparathyroidism in most cases.
  • [MeSH-major] Hyperparathyroidism, Primary / surgery. Monitoring, Intraoperative / methods. Parathyroid Hormone / blood. Parathyroidectomy / methods

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18849859.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Parathyroid Hormone
  •  go-up   go-down


96. Franchello A, Camandona M, Gasparri G: Acute hyperparathyroidism and vascular thrombosis; an unrecognized association. J Endocrinol Invest; 2010 Oct;33(9):683
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute hyperparathyroidism and vascular thrombosis; an unrecognized association.
  • [MeSH-major] Hyperparathyroidism / complications. Thrombosis / etiology
  • [MeSH-minor] Acute Disease. Adenoma / complications. Adenoma / epidemiology. Adenoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Male. Middle Aged. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / epidemiology. Parathyroid Neoplasms / surgery. Postoperative Complications / epidemiology. Postoperative Complications / etiology. Retrospective Studies. Young Adult

  • Genetic Alliance. consumer health - Thrombosis.
  • MedlinePlus Health Information. consumer health - Blood Clots.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):619-24 [18484067.001]
  • [Cites] J Am Coll Surg. 2008 Jun;206(6):1106-15 [18501807.001]
  • [Cites] Eur J Endocrinol. 2009 May;160(5):863-8 [19233920.001]
  • [Cites] J Endocrinol Invest. 2009 Apr;32(4):317-21 [19636198.001]
  • (PMID = 21099247.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Italy
  •  go-up   go-down


97. Adler JT, Chen H, Schaefer S, Sippel RS: Does routine use of ultrasound result in additional thyroid procedures in patients with primary hyperparathyroidism? J Am Coll Surg; 2010 Oct;211(4):536-9
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does routine use of ultrasound result in additional thyroid procedures in patients with primary hyperparathyroidism?
  • BACKGROUND: Minimally invasive parathyroidectomy for primary hyperparathyroidism depends on accurate preoperative imaging.
  • Cervical ultrasound is commonly used to localize parathyroid adenomas, but can lead to discovery of concomitant thyroid gland pathology requiring modification of the operative approach.
  • RESULTS: Between July 2002 and November 2009, 310 patients with primary hyperparathyroidism underwent ultrasound.
  • Thirteen patients (4% of all patients) underwent a thyroid operation not related to parathyroid disease: 9 thyroid lobectomies for presumably benign nodules and 4 total thyroidectomies for malignancy.
  • CONCLUSIONS: Twenty-nine percent of patients with primary hyperparathyroidism had concomitant thyroid pathology on ultrasound.
  • Routine use of ultrasound in patients with primary hyperparathyroidism leads to discovery of unrecognized thyroid pathology and cancer.
  • [MeSH-major] Adenocarcinoma, Papillary / ultrasonography. Hyperparathyroidism, Primary / surgery. Hyperparathyroidism, Primary / ultrasonography. Thyroid Neoplasms / ultrasonography. Thyroid Nodule / pathology. Thyroidectomy
  • [MeSH-minor] Biopsy, Fine-Needle. Female. Humans. Incidental Findings. Male. Middle Aged. Reoperation. Thyroid Gland / ultrasonography. Treatment Outcome

  • Genetic Alliance. consumer health - Hyperparathyroidism, primary.
  • MedlinePlus Health Information. consumer health - Thyroid Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20822743.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


98. Oh SY, Kim S, Eskandar Y, Kim DW, Krynyckyi BR, Machac J, Inabnet WB 3rd, Kim CK: Appearance of intrathymic parathyroid adenomas on pinhole sestamibi parathyroid imaging. Clin Nucl Med; 2006 Jun;31(6):325-7
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appearance of intrathymic parathyroid adenomas on pinhole sestamibi parathyroid imaging.
  • OBJECTIVES: Ectopic inferior parathyroid adenomas (PAs) are frequently located in the anterior mediastinum, quite often in the thymus gland.
  • Clinical follow up has shown that most intrathymic adenomas were visualized on pinhole views and located closer to the thyroid than expected.
  • METHODS: We retrospectively reviewed sestamibi pinhole parathyroid imaging performed on 163 patients with primary hyperparathyroidism and final diagnoses established by surgery, histology, intraoperative PTH monitoring, and clinical follow up.
  • Of the 93 foci in group A, there were 80 normally situated inferior PA, 6 descended superior PA, 3 intrathyroidal PA, one hyperplastic parathyroid gland, one thyroid adenoma, one unidentified, and one intrathymic PA.
  • CONCLUSION: Focal increased activity completely separated from the lower pole of thyroid (regardless of the distance of separation) on sestamibi pinhole images indicates a high probability of intrathymic parathyroid adenoma.
  • [MeSH-major] Adenoma / radionuclide imaging. Parathyroid Neoplasms / radionuclide imaging. Technetium Tc 99m Sestamibi. Thymus Neoplasms / radionuclide imaging. Thymus Neoplasms / secondary. Tomography, Emission-Computed, Single-Photon / methods

  • MedlinePlus Health Information. consumer health - Thymus Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16714889.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 971Z4W1S09 / Technetium Tc 99m Sestamibi
  •  go-up   go-down


99. Corbetta S, Vaira V, Guarnieri V, Scillitani A, Eller-Vainicher C, Ferrero S, Vicentini L, Chiodini I, Bisceglia M, Beck-Peccoz P, Bosari S, Spada A: Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue. Endocr Relat Cancer; 2010 Mar;17(1):135-46
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue.
  • Parathyroid carcinoma (PaC) is a rare cause of primary hyperparathyroidism.
  • Though the loss of the oncosuppressor CDC73/HRPT2 gene product, parafibromin, has been involved in the hyperparathyroidism-jaw tumor syndrome and in a consistent set of sporadic PaCs, parathyroid carcinogenesis remains obscure.
  • The aim of the present study was to identify differentially expressed microRNAs in parathyroid cancers compared with normal tissues.
  • We performed a TaqMan low-density array profiling of four parathyroid cancers harboring CDC73 inactivating mutations and negative for parafibromin immunostaining.
  • Their microRNA profiling was compared with that of two normal parathyroid biopsies.
  • Fourteen and three microRNAs were significantly down- and over-expressed in parathyroid cancers respectively.
  • Carcinomas could be discriminated from parathyroid adenomas by a computed score based on the expression levels of miR-296, miR-222, and miR-503 as miR-139 was similarly down-regulated in both cancers and adenomas.
  • [MeSH-major] Adenoma / genetics. Carcinoma / genetics. MicroRNAs / genetics. Parathyroid Glands / metabolism. Parathyroid Neoplasms / genetics

  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19926710.001).
  • [ISSN] 1479-6821
  • [Journal-full-title] Endocrine-related cancer
  • [ISO-abbreviation] Endocr. Relat. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MIRN296 microRNA, human; 0 / MicroRNAs
  •  go-up   go-down


100. Târcoveanu E, Niculescu D, Cotea E, Moldovanu R, Vasilescu A, Crumpei F, Zbranca E, Zugun F, Rusu V, Ferariu D: [Parathyroid glands involvement in multiple endocrine neoplasia]. Rev Med Chir Soc Med Nat Iasi; 2009 Apr-Jun;113(2):482-96
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Parathyroid glands involvement in multiple endocrine neoplasia].
  • Parathyroid gland involvement is usually noted in Multiple Endocrine Neoplasia (MEN) type I and type II.
  • Parathyroid glands tumor associated with endocrine pancreatic tumor, as well as pituitary tumors is the typical pattern of MEN I.
  • The parathyroid gland is the most frequent abnormality in MEN I.
  • CASES REPORTS: We presented five cases with MEN I and parathyroid glands involvement.
  • In three cases with young ages (28-33 years old) and familial setting, the MEN I syndrome was "complete" (parathyroid adenoma, gastrinoma or insulinoma and pituitary adenoma--prolactinoma or GH-secreting tumors), and, in the other two cases, with 57 and 68 years old respectively, the MEN I syndrome was "incomplete" with parathyroid glands and pituitary gland involvement.
  • Unfortunately one patients died due to severe endocrine disorder.
  • During the necropsy, the pituitary adenoma has been diagnosed.
  • The imagistic and laboratory test diagnosed a tumor situated into the pancreatic body, and an parathyroid adenoma.
  • The resection of pancreatic tumor associated with resection of the parathyroid adenoma, in the same time, were performed.
  • The other two cases with "incomplete" MEN were older then the first patients, and were diagnosed with hyperparathyrodism and pituitary gland tumor.
  • The resection of parathyroid gland adenoma has been performed in both cases, with uneventful postoperative course.
  • CONCLUSIONS: The parathyroid glands involvement in MEN is common.
  • There are two kinds of MEN associated with parathyroid gland involvement: the "complete" form, especially in young patients, with diffuse involvement of the parathyroid glands, and the subtotal parathyroidy is the best choice, and the "incomplete" form, especially in elderly, with the involvement of a single parathyroid gland; in this way, the resection of the adenoma associated with biopsy from the other parathyroid gland is the best approach.
  • [MeSH-major] Adenoma / surgery. Gastrinoma / surgery. Insulinoma / surgery. Multiple Endocrine Neoplasia Type 1 / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy
  • [MeSH-minor] Adult. Aged. Fatal Outcome. Female. Humans. Hyperparathyroidism, Secondary / diagnosis. Hyperparathyroidism, Secondary / etiology. Male. Middle Aged. Multiple Endocrine Neoplasia / surgery. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / surgery. Prolactinoma / diagnosis. Prolactinoma / surgery. Treatment Outcome

  • Genetic Alliance. consumer health - Multiple Endocrine Neoplasia.
  • MedlinePlus Health Information. consumer health - Pancreatic Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21495355.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
  •  go-up   go-down






Advertisement