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1. Obulareddy SJ, Xin J, Truskinovsky AM, Anderson JK, Franklin MJ, Dudek AZ: Metanephric adenoma of the kidney: an unusual diagnostic challenge. Rare Tumors; 2010;2(2):e38
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metanephric adenoma of the kidney: an unusual diagnostic challenge.
  • Although metanephric adenoma (MA) is a rare, benign neoplasm of epithelial cells, it is often difficult to distinguish this entity from other malignant neoplasms preoperatively.
  • We report a case of a large renal mass for which preoperative diagnosis was indeterminate, with the differential diagnosis including Wilm's tumor, MA, and papillary renal cell carcinoma (PRCC).

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  • (PMID = 21139840.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994510
  • [Keywords] NOTNLM ; Wilm’s tumor / differential diagnosis. / metanephric adenoma / papillary renal cell carcinoma
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2. Bastide C, Rambeaud JJ, Bach AM, Russo P: Metanephric adenoma of the kidney: clinical and radiological study of nine cases. BJU Int; 2009 Jun;103(11):1544-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metanephric adenoma of the kidney: clinical and radiological study of nine cases.
  • OBJECTIVE To analyse the clinical and radiological features of metanephric adenoma (MA, a rare benign renal tumour) in nine patients, and to review previous reports.
  • Renal colour Doppler ultrasonography (US), abdominal computed tomography and abdominal magnetic resonance imaging were used in seven, eight and four patients, respectively.
  • CONCLUSIONS Renal MA is a benign tumour occurring mainly in young and middle-aged women.
  • Based on a combination of clinical and imaging features, it might be possible to suspect the diagnosis of MA and propose a preoperative diagnostic biopsy, a partial nephrectomy or active surveillance.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Nephrectomy / methods

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  • (PMID = 19220269.001).
  • [ISSN] 1464-410X
  • [Journal-full-title] BJU international
  • [ISO-abbreviation] BJU Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. Nakane K, Yuhara K, Kanimoto Y: [Renal adenoma treated with partial nephrectomy: a case report]. Hinyokika Kiyo; 2007 Jul;53(7):473-5
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  • [Title] [Renal adenoma treated with partial nephrectomy: a case report].
  • We report a case of renal adenoma which was diagnosed as renal cell carcinoma preoperatively.
  • A 78-year-old man, who had been under observation for bladder cancer for 4 years, was incidentally found to have a small right renal tumor at follow-up computed tomography (CT).
  • Enhanced CT demonstrated a tumor which was hypervascular, 10 x 10 mm size, at the lower pole of the right kidney.
  • The preoperative diagnosis was renal cell carcinoma, cT1aN0M0, and we performed right partial nephrectomy.
  • The histopathorogical finding was renal adenoma.
  • Renal adenomas are benign tumors and not uncommon in autopsy cases.
  • However, when they are detected clinically, it is difficult to distinguish them from renal cell carcinoma preoperatively.
  • [MeSH-major] Adenoma / surgery. Kidney Neoplasms / surgery. Nephrectomy
  • [MeSH-minor] Aged. Carcinoma, Renal Cell. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 17702180.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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4. Olgac S, Hutchinson B, Tickoo SK, Reuter VE: Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma. Mod Pathol; 2006 Feb;19(2):218-24
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  • [Title] Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma.
  • Metanephric adenoma (MA), a well-described renal neoplasm, usually behaves in a benign fashion.
  • It may have areas that are morphologically similar to papillary renal cell carcinoma (RCC) type, or epithelial (tubular predominant) type Wilms' tumor.
  • Recent microarray analysis of renal tumors has shown an increase of AMACR mRNA levels in papillary RCC but not in other subtypes.
  • In conclusion, diffuse and strong immunoreactivity for AMACR may be useful in differentiating papillary RCC from MA but a panel which includes AMACR, CK7 and CD57 is better in this differential diagnosis.
  • AMACR is not helpful in differentiating MA from Wilms' tumor, but CD57 is helpful in this differential diagnosis.
  • [MeSH-major] Adenoma / pathology. Biomarkers, Tumor / analysis. Kidney Neoplasms / pathology. Racemases and Epimerases / analysis
  • [MeSH-minor] Antigens, CD57 / analysis. Carcinoma, Papillary / enzymology. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / enzymology. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis. WT1 Proteins / analysis. Wilms Tumor / enzymology. Wilms Tumor / pathology

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  • (PMID = 16424894.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / WT1 Proteins; 68238-35-7 / Keratins; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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5. Schmelz HU, Stoschek M, Schwerer M, Danz B, Hauck EW, Weidner W, Sparwasser C: Metanephric adenoma of the kidney: case report and review of the literature. Int Urol Nephrol; 2005;37(2):213-7
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  • [Title] Metanephric adenoma of the kidney: case report and review of the literature.
  • Metanephric adenoma is a rare tumor of the kidney.
  • So far metanephric adenomas were considered to be benign, slowly growing and non-metastasizing tumors with an excellent prognosis.
  • Only recently two cases of metastasized metanephric adenomas were published.
  • We report the case of a 42 year old male with metanephric adenoma.
  • Current literature concerning metanephric adenoma is reviewed.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis

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  • (PMID = 16142545.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Hungary
  • [Number-of-references] 32
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6. Yaqoob N, Paryani JP, Kayani N, Rafique MZ, Biyabani R: Metanephric adenoma: a rare benign renal tumour. J Pak Med Assoc; 2005 Nov;55(11):511-2
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  • [Title] Metanephric adenoma: a rare benign renal tumour.
  • Metanephric adenoma is a rare benign renal tumour.
  • Nephrectomy was done and histopathology was consistent with the diagnosis of metanephric adenoma.
  • This novel renal mass has been reported to have benign clinical course despite its symptomatic presentation and large tumour size.
  • So far, a uniformly benign clinical course has been associated with Metanephric adenoma, but given its relatively recent identification and rarity and the lack of clinical, radiographic, or cytologic means to establish a definite diagnosis, Metanephric adenoma remains primarily a pathologic diagnosis.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis. Nephrectomy

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  • (PMID = 16304876.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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7. Algaba F: Renal adenomas: pathological differential diagnosis with malignant tumors. Adv Urol; 2008;:974848

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal adenomas: pathological differential diagnosis with malignant tumors.
  • The renal adenomas can be confused by imaging diagnosis with malignant renal tumors, but there are also real biological dilemmas to determine their behavior.
  • The consensus decisions are the following. (1) The adenoma of clear cells is not accepted, instead it is considered that all the clear-cell tumors are carcinomas, with greater or lesser aggressiveness. (2) Among the papillary neoplasms the WHO 2004 renal cell tumors classification are considered as papillary adenomas tumors with a maximum diameter of 5 mm and may represent a continuum biological process to papillary renal cell carcinoma.
  • The papillary adenomas associated with End-kidney and/or acquired cystic disease may have a different pathogenesis. (3) To consider a tumor as an oncocytoma the size is not important, only the cytological features, microscopic, ultrastructural, and immunohistochemically can help, but some chromosomal observations introduce some questions about its relation with the chromophobe renal cell carcinoma. (4) Finally, the metanephric adenoma, a tumor with some morphological similarity with the nephroblastoma must be considered in the renal adenomas diagnosis.

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  • [Cites] J Endourol. 2007 Aug;21(8):819-23 [17867935.001]
  • [Cites] Am J Surg Pathol. 2007 Apr;31(4):489-500 [17414095.001]
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  • [Cites] Mod Pathol. 2006 Feb;19(2):218-24 [16424894.001]
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  • (PMID = 18846240.001).
  • [ISSN] 1687-6369
  • [Journal-full-title] Advances in urology
  • [ISO-abbreviation] Adv Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2563151
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8. Terao H, Matsumoto T, Umemoto S, Onuki T, Kobayashi K, Ohgo Y, Nogcchi S, Kishi H, Tsuura Y, Nagashima Y: [Metanephric adenoma: report of two cases]. Hinyokika Kiyo; 2008 Sep;54(9):599-602
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  • [Title] [Metanephric adenoma: report of two cases].
  • We report 2 cases of metanephric adenoma a rare form of adenoma.
  • One case occurred in a 54-year-old male preoperatively diagnosed with renal cell carcinoma who underwent left partial nephrectomy for a tumor 2 cm in size.
  • Thus, the patient was diagnosed with metanephric adenoma.
  • The other case occurred in a 40-year-old male who underwent left nephroureterectomy for carcinoma of the renal pelvis.
  • Carcinoma of the left renal pelvis was diagnosed as pT3N0M0.
  • Incidental micronodules 2 mm in size and consisting of immature tubular structures were noted in the renal cortex.
  • In immunohistochemical staining, tumor cells were positive for CD57 and WT-1, and the patient was diagnosed with metanephric adenoma.
  • The aforementioned tumors frequently occur in middle-aged women and are often well-defined tumors that project from the renal surface outwards.
  • On angiography, they have a hypovascular pattern and resemble papillary renal carcinoma.
  • Preoperative differentiation of renal cell carcinoma and nephroblastoma is difficult.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, CD57 / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Kidney Pelvis. Male. Middle Aged. Neoplasm Staging. Nephrectomy. Tomography, X-Ray Computed. Ureter / surgery. WT1 Proteins / analysis

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  • (PMID = 18975573.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / WT1 Proteins
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9. Denzinger S, Burger M, Hartmann A, Hofstaedter F, Wieland WF, Ganzer R: Spontaneous rupture of a benign giant adrenal adenoma. APMIS; 2007 Apr;115(4):381-4
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  • [Title] Spontaneous rupture of a benign giant adrenal adenoma.
  • We report on a 50-year-old patient with a giant benign adenoma of the adrenal cortex, which ruptured spontaneously, leading to life-threatening retroperitoneal hemorrhage.
  • Following emergency adrenalectomy with sparing of the ipsilateral kidney, an adenoma of the adrenal cortex with a diameter of 18 cm and a weight of 1400 g was found.
  • A detailed literature search showed this to be the largest benign tumor of the adrenal cortex described so far.
  • We discuss the diagnosis and treatment of this unusual tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenocortical Adenoma / diagnosis
  • [MeSH-minor] Humans. Middle Aged. Rupture, Spontaneous / diagnosis. Rupture, Spontaneous / pathology. Rupture, Spontaneous / surgery. Treatment Outcome

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  • (PMID = 17504308.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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10. Bosco M, Galliano D, La Saponara F, Pacchioni D, Bussolati G: Cytologic features of metanephric adenoma of the kidney during pregnancy: a case report. Acta Cytol; 2007 May-Jun;51(3):468-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic features of metanephric adenoma of the kidney during pregnancy: a case report.
  • BACKGROUND: Metanephric adenoma (MA) is a relatively rare neoplasm derived from metanephric blastema and composed of well-differentiated epithelial nephroblastic cells.
  • In view of its invariably benign clinical outcome, a preoperative diagnosis of this tumor could be of critical importance.
  • Since computed tomography and ultrasound imaging are not per se sufficient to unequivocally distinguish between MA and malignant neoplasms, fine needle aspiration cytology (FNAC) could be the only accurate method to establish a preoperative diagnosis of this tumor.
  • Transabdominal ultrasound examination disclosed a mass in her left kidney.
  • These cytologic and immunocytochemicalfindings led to a preoperative diagnosis of MA.
  • After delivery, the diagnosis was confirmed on the surgical specimen.
  • CONCLUSION: A diagnosis of MA could be established by FNAC supported by immunocytochemical analysis.
  • The present case illustrates the clinical impact that this diagnosis could have on patient management.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 17536558.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Lara C, Porras V, Jurado P, Arredondo F: [Metanephric adenoma. Case report]. Arch Esp Urol; 2007 Nov;60(9):1.122-4
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  • [Title] [Metanephric adenoma. Case report].
  • [Transliterated title] Adenoma metanéfrico. Presentación de un caso.
  • OBJECTIVE: Metanephric adenoma is an unfrequent renal neoplasm, usually asymptomatic.
  • Differential diagnosis with other renal tumors has to be performed.
  • METHODS/RESULTS: We report the case of a 67 years old woman with a metanephric adenoma.
  • At one end of the pathologic spectrum are the metanephric adenomas.
  • These tumors usually behave in a benign fashion.
  • It is important to differentiate metanephric adenoma from clinically aggressive renal tumors.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 18077869.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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12. Sokolova IA, Matsko DE, Hes O, Michal M: [Mucinous tubular and spindle-cell carcinoma of the kidney]. Arkh Patol; 2006 Jul-Aug;68(4):14-5
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  • [Title] [Mucinous tubular and spindle-cell carcinoma of the kidney].
  • 4 cases (2 males and 2 females) of mucinous tubular and spindle-cell carcinoma of the kidney were studied.
  • Microscopically, this tumor comprised two major cell populations.
  • Only one tumor had both cell components.
  • Mucinous tubular and spindle-cell carcinoma of the kidney should be differentiated from angiomyolipoma with the preponderance of a leiomyomatous component, renal smooth muscle neoplasms, metanephrotic adenoma, and renal cell carcinoma with sarcomatoid differentiation.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Kidney Tubules / pathology. Male. Middle Aged

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  • (PMID = 16986488.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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13. Frickmann H, Jungblut S, Bargon J, Willenbrock K, Störkel S, Hanke P: [Villous adenoma of the renal pelvis and ureter]. Urologe A; 2006 Nov;45(11):1435-7
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  • [Title] [Villous adenoma of the renal pelvis and ureter].
  • [Transliterated title] Villöses Adenom des Nierenbeckens und Ureters.
  • Villous adenomas of the urinary tract are extremely rare tumours belonging to the adenoepithelial metaplasias.
  • We describe the case of an 85-year-old female patient suffering from a villous adenoma of the renal pelvis and ureter.
  • [MeSH-major] Adenoma, Villous / diagnosis. Carcinoma in Situ / diagnosis. Kidney Neoplasms / diagnosis. Kidney Pelvis. Neoplasms, Multiple Primary / diagnosis. Ureteral Neoplasms / diagnosis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Nephrectomy. Tomography, X-Ray Computed. Ultrasonography. Ureter / pathology. Ureter / surgery

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  • (PMID = 16900367.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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14. Torres Gómez FJ, Torres Olivera FJ, García Escudero A: [Predominantly cystic renal metanephric adenoma. Case report]. Arch Esp Urol; 2006 Jan-Feb;59(1):90-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Predominantly cystic renal metanephric adenoma. Case report].
  • [Transliterated title] Adenoma metanéfrico renal de predominio quístico. A propósito de un caso.
  • OBJECTIVES: Metanephric adenoma is a relatively unfrequent asymptomatic embryogenic renal tumor which is generally diagnosed by an abdominal diagnostic tests indicated for other reasons.
  • Differential diagnosis with benign and malignant tumors has to be performed.
  • METHODS/RESULTS: We report one case of metanephric adenoma with intense necrotic-hemorrhagic and cystic changes with a size not previously referred in the literature.
  • CONCLUSIONS: Cystic and hemorrhagic changes in benign renal tumors make differential diagnosis with malignant tumors mandatory Surgery is necessary in almost all cases and histologic study will give the diagnosis.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16568702.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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15. Amin W, Parwani AV: Nephrogenic adenoma. Pathol Res Pract; 2010 Oct 15;206(10):659-62
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  • [Title] Nephrogenic adenoma.
  • Nephrogenic adenoma is an uncommon benign lesion.
  • The proposal that nephrogenic adenoma originates from the implantation of exfoliated renal tubular cells is lately gaining wider acceptance.
  • The role of immunohistochemistry cannot be undermined in the diagnosis of nephrogenic adenoma, although histological diagnosis is usually conclusive.
  • The possibility of nephrogenic adenoma should always be in the differential diagnosis when evaluating patients with predisposed urinary tract symptoms.
  • [MeSH-major] Adenoma / pathology. Kidney Tubules / pathology. Urologic Neoplasms / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Humans. Immunohistochemistry. Predictive Value of Tests. Recurrence. Treatment Outcome. Urine / cytology

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20619548.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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16. Fromont G, Barcat L, Gaudin J, Irani J: Revisiting the immunophenotype of nephrogenic adenoma. Am J Surg Pathol; 2009 Nov;33(11):1654-8
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  • [Title] Revisiting the immunophenotype of nephrogenic adenoma.
  • Nephrogenic adenoma (NA) is a rare benign lesion of the urinary tract.
  • Although its histogenesis is still debated, several reports suggest that the lesion has a renal tubular cell origin or differentiation.
  • Because all the previous studies have used an avidin-biotin (AB) detection procedure, and because cells with tubular renal differentiation are likely to contain a high level of endogenous biotin, we investigated in NA the expression of several markers including AMACR, using both AB and biotin-free detection systems.
  • We assessed the expression of p63, cytokeratins 7 and 20, CD10 (proximal tubule marker), MUC1 (distal tubule marker), PAX2, and AMACR on 14 NAs (from 6 patients) grouped on a tissue microarray.
  • The tissue microarray also included renal, urothelial, and prostate tissues.
  • Detection with the AB procedure leads to nonspecific staining in kidney samples and NA.
  • These findings provide supporting evidence that NA has the differentiation of distal renal tubules, and strongly suggest that AMACR, when detected with a biotin-free procedure, can be used as a reliable marker for distinguishing NA from prostate cancer.
  • [MeSH-major] Adenoma / immunology. Immunophenotyping / methods. Urologic Neoplasms / immunology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Child. Diagnosis, Differential. Female. Fluorescent Antibody Technique, Indirect. Humans. Kidney Tubules / enzymology. Male. Middle Aged. Prostatic Neoplasms / diagnosis. Racemases and Epimerases / metabolism. Tissue Array Analysis

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  • (PMID = 19730362.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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17. Liniger B, Wolf RW, Fleischmann A, Kluwe W: Local resection of metanephric adenoma with kidney preservation. J Pediatr Surg; 2009 Aug;44(8):E21-3
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  • [Title] Local resection of metanephric adenoma with kidney preservation.
  • Metanephric adenoma (MA) is a rare renal neoplasm present at any age.
  • Today, 2 1/2 years after surgery, we can document a favorable clinical course and normal ultrasound findings in the follow-up of the operated kidney.
  • [MeSH-major] Adenoma / surgery. Kidney Neoplasms / surgery. Nephrectomy / methods

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  • (PMID = 19635287.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Galmiche L, Vasiliu V, Poirée S, Hélénon O, Casanova JM, Brousse N: [Diagnosis of renal metanephric adenoma: relevance of immunohistochemistry and biopsy]. Ann Pathol; 2007 Oct;27(5):365-8
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  • [Title] [Diagnosis of renal metanephric adenoma: relevance of immunohistochemistry and biopsy].
  • [Transliterated title] Diagnostic d'adénome métanéphrique rénal: Intérêt de l'immunohistochimie et apport de la biopsie.
  • Most renal tumors of the adult are carcinomas.
  • We report the case of a 45 year-old woman presenting with renal tumor.
  • A biopsy of the mass showed a metanephric adenoma.
  • Here we develop the interest of immunohistochemistry for differential diagnosis of metanephric adenoma and other "basophilic small cell tumors" of the kidney.
  • We also put the stress on the growing role of biopsy of renal tumor allowing optimal treatment.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 18185471.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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19. Rahemtullah A, Oliva E: Nephrogenic adenoma: an update on an innocuous but troublesome entity. Adv Anat Pathol; 2006 Sep;13(5):247-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nephrogenic adenoma: an update on an innocuous but troublesome entity.
  • Nephrogenic adenoma (NA) is a rare benign lesion of the urothelial tract that is typically preceded by some form of genitourinary insult.
  • Although generally presumed to be a metaplastic process of the urothelium, recent evidence suggests that NA may in fact be derived from detached renal tubular cells implanting along the urothelial tract in previously injured areas, at least in cases associated with a kidney transplant.
  • Recognition of its characteristic patterns, and awareness of its unusual architectural and cytologic features, is key to making the diagnosis of NA and distinguishing this lesion from malignant neoplasms occurring at the same sites, in particular, clear cell carcinoma, nested or microcystic variants of urothelial carcinoma and prostatic adenocarcinoma.
  • Although straightforward in most cases, the correct diagnosis may be difficult to make on limited tissue samples.
  • Clinicopathologic correlation with careful attention to morphology remains the pillar in establishing the correct diagnosis.
  • [MeSH-major] Adenoma / pathology. Urologic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Prostatic Neoplasms / pathology. Urothelium / pathology

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  • (PMID = 16998318.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 64
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20. TAIPAI Study Group, Wu VC, Chueh SC, Chang HW, Lin LY, Liu KL, Lin YH, Ho YL, Lin WC, Wang SM, Huang KH, Hung KY, Kao TW, Lin SL, Yen RF, Chen YM, Hsieh BS, Wu KD: Association of kidney function with residual hypertension after treatment of aldosterone-producing adenoma. Am J Kidney Dis; 2009 Oct;54(4):665-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of kidney function with residual hypertension after treatment of aldosterone-producing adenoma.
  • BACKGROUND: Autonomous secretion of aldosterone in patients with primary aldosteronism increases glomerular filtration rate and causes kidney damage.
  • The influence of a mild decrease in kidney function on residual hypertension after adrenalectomy is unexplored.
  • 150 patients (61 men; overall mean age, 47.2 +/- 11.6 years) with a diagnosis of aldosterone-producing adenoma had undergone unilateral adrenalectomy at National Taiwan University Hospital from July 1999 to January 2007.
  • CONCLUSIONS: Two-thirds of patients with aldosterone-producing adenoma were cured of hypertension by means of unilateral adrenalectomy.
  • Kidney function impairment, even mild, appears to be associated with a high incidence of postsurgery residual hypertension.
  • [MeSH-major] Adenoma / physiopathology. Adrenal Cortex Neoplasms / physiopathology. Adrenalectomy. Aldosterone / blood. Glomerular Filtration Rate. Hypertension / physiopathology. Kidney / physiopathology
  • [MeSH-minor] Adult. Blood Pressure. Creatinine / blood. Female. Humans. Hyperaldosteronism / blood. Hyperaldosteronism / etiology. Hyperaldosteronism / metabolism. Hyperaldosteronism / physiopathology. Kidney Function Tests. Male. Middle Aged. Odds Ratio. Retrospective Studies. Severity of Illness Index

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  • [CommentIn] Am J Kidney Dis. 2009 Oct;54(4):594-7 [19781452.001]
  • (PMID = 19628318.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; AYI8EX34EU / Creatinine
  • [Investigator] Wu VC; Lin YH; Ho YL; Chang HW; Lin LY; Hu FC; Liu KL; Wang SM; Huang KH; Chang FC; Chen YM; Kuo CC; Chueh SC; Lu CC; Chang FC; Liao SC; Yen RF; Lin WC; Hsieh BS; Wu KD; Hsien FF
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21. Miles LF, Wakeman CJ, Farmer KC: Giant villous adenoma presenting as McKittrick-Wheelock syndrome and pseudo-obstruction. Med J Aust; 2010 Feb 15;192(4):225-7
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  • [Title] Giant villous adenoma presenting as McKittrick-Wheelock syndrome and pseudo-obstruction.
  • McKittrick-Wheelock syndrome is a rare but recognised complication of hypersecretory rectosigmoid villous adenoma.
  • We report an unusual presentation of the syndrome associated with the development of acute pseudo-obstruction of the colon, presumably due to electrolyte dysfunction and acute renal failure.
  • [MeSH-major] Acute Kidney Injury / etiology. Adenoma, Villous / complications. Colonic Neoplasms / complications. Colonic Pseudo-Obstruction / etiology. Water-Electrolyte Imbalance / etiology
  • [MeSH-minor] Aged. Colonoscopy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Syndrome. Tomography, X-Ray Computed

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  • (PMID = 20170462.001).
  • [ISSN] 0025-729X
  • [Journal-full-title] The Medical journal of Australia
  • [ISO-abbreviation] Med. J. Aust.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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22. Bastos Netto JM, Esteves TC, Mattos Rde C, Tibiriçá SH, Costa SM, Vieira LJ: Metanephric adenoma: a rare differential diagnosis of renal tumor in children. J Pediatr Urol; 2007 Aug;3(4):340-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metanephric adenoma: a rare differential diagnosis of renal tumor in children.
  • Metanephric adenoma is an extremely rare tumor of the kidney.
  • The clinical and anatomic characteristics are not yet well defined, but it is currently considered to be a benign tumor with a good prognosis, although recently two metastatic cases have been reported.
  • We present here the youngest girl yet to be reported with a diagnosis of metanephric adenoma.

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  • (PMID = 18947770.001).
  • [ISSN] 1873-4898
  • [Journal-full-title] Journal of pediatric urology
  • [ISO-abbreviation] J Pediatr Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Ahmad S, Jielani AA, Khan K, Fatima T, Zia N, ud Duha M, Samad A, Memon K: Dual phase MIBI scintigraphy in diagnosis of parathyroid adenoma followed by ultrasound guided percutaneous alcoholic ablation. J Ayub Med Coll Abbottabad; 2008 Jul-Sep;20(3):149-51
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  • [Title] Dual phase MIBI scintigraphy in diagnosis of parathyroid adenoma followed by ultrasound guided percutaneous alcoholic ablation.
  • Primary HPT is caused by parathyroid adenoma in 80-85% of patients.
  • Clinical manifestations are kidney stones, abdominal groans, painful bones, psychic moans, and fatigue overtones.
  • Ultrasonography is widely used in suspected cases for localization of parathyroid adenoma.
  • Dual phase Tc-99m MIBI scinitigraphy for detection of parathyroid adenomas has sensitivity and specificity values ranging from 82% to 100% and from 89% to 100%, respectively.
  • [MeSH-major] Adenoma / radionuclide imaging. Adenoma / therapy. Catheter Ablation / methods. Ethanol / therapeutic use. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / therapy

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  • (PMID = 19610543.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 3K9958V90M / Ethanol; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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24. Linder B, Hong Y, Jarrett T: Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass. Int J Urol; 2009 Nov;16(11):912-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intra-renal adrenal adenoma: a compelling addition to the differential diagnosis of renal mass.
  • We report a case of an adrenal rest arising in the kidney of a 37-year-old male.
  • Laparoscopic renal exploration and biopsy revealed angiomyolipoma on frozen section.
  • However, final pathological analysis of the partial nephrectomy specimen revealed intra-renal adrenal adenoma.
  • The diagnosis was confirmed by immunohistochemistries and transmission electron microscopy.
  • We review the reported literature on intra-renal adrenal adenoma and highlight the aspects that raise the index of suspicion for this entity on the differential diagnosis of renal masses.
  • [MeSH-major] Adenoma / diagnosis. Adrenal Gland Neoplasms / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Invasiveness

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  • (PMID = 19863627.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 8
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25. Loeser A, Katzenberger T, Spahn M, Gerharz EW, Riedmiller H: Metanephric adenoma in a two-year-old child. Urol Int; 2009;83(1):119-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metanephric adenoma in a two-year-old child.
  • Metanephric adenomas in children are very rare.
  • We present the case of a 2-year-old girl with a mass of the left kidney.
  • Histopathologic examination revealed a metanephric adenoma.
  • [MeSH-major] Adenoma / diagnosis. Kidney Neoplasms / diagnosis

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19641372.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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26. Lerut E, Roskams T, Joniau S, Oyen R, Achten R, Van Poppel H, Debiec-Rychter M: Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics. Hum Pathol; 2006 Sep;37(9):1227-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics.
  • Metanephric adenoma is a rare benign tumor of the kidney.
  • It is considered to be derived from embryonic renal tissue and to be the benign counterpart of the Wilms tumor.
  • At renal ultrasonography and magnetic resonance imaging, a hemorrhagic tumor of 10 cm in diameter originating from the right kidney was seen.
  • Based on the imaging findings, the diagnosis of a cystic renal cell carcinoma with recent hemorrhage was suggested, and a radical nephrectomy was performed.
  • Pathologic examination concluded to a metanephric adenoma.
  • To our knowledge, this is the first report on these chromosomal abnormalities in metanephric adenoma.
  • [MeSH-major] Adenoma / genetics. Adenoma / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology. Pregnancy Complications / genetics. Pregnancy Complications / pathology
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / pathology. Chromosome Aberrations. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Kidney / embryology. Kidney / pathology. Magnetic Resonance Imaging. Nephrectomy. Pregnancy. Ultrasonography. Wilms Tumor / pathology


27. Khayyata S, Grignon DJ, Aulicino MR, Al-Abbadi MA: Metanephric adenoma vs. Wilms' tumor: a report of 2 cases with diagnosis by fine needle aspiration and cytologic comparisons. Acta Cytol; 2007 May-Jun;51(3):464-7
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  • [Title] Metanephric adenoma vs. Wilms' tumor: a report of 2 cases with diagnosis by fine needle aspiration and cytologic comparisons.
  • BACKGROUND: Metanephric adenoma (MA) is a rare benign renal neoplasm that can occur at any age, whereas, Wilms' tumor (WT) is the most common malignant renal neoplasm in children and is occasionally seen in adults.
  • CASES: In case 1, a 26-year-old male had a left renal mass.
  • The cytologic differential diagnosis included Wilms' tumor, neuroectodermal tumor and metanephric adenoma.
  • In case 2, a 24-year-old female presented with erythrocytosis and a right renal mass.
  • A diagnosis of metanephric adenoma was made and confirmed on nephrectomy.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology. Wilms Tumor / diagnosis. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Cell Nucleolus / pathology. Cell Nucleus Shape. Diagnosis, Differential. Female. Humans. Kidney / pathology. Kidney / surgery. Male. Nephrectomy


28. National Toxicology Program: Toxicology and carcinogenesis studies of cumene (CAS No. 98-82-8) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2009 Feb;(542):1-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Adenomas of the respiratory epithelium of the nose were observed in male and female rats, and male rats had increased incidences of renal tubule adenoma or carcinoma (combined) and interstitial cell adenoma of the testis.
  • Adenomas and carcinomas of the lung were markedly increased in male and female mice exposed to cumene.
  • The rate of liver neoplasms was also increased in exposed female mice, and a few hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland were seen in male mice exposed to the highest concentration of cumene.
  • CONCLUSIONS: We conclude that the increased occurrences of adenomas of the epithelium of the nose in male and female rats, of renal tubule adenoma or carcinoma (combined), of adenomas and carcinomas of the lung in male and female mice, and of liver neoplasms in female mice were caused by exposure to cumene.
  • The occurrence of interstitial cell adenoma of the testis in male rats and hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland in male mice may also have been associated with exposure to cumene.

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  • (PMID = 19340095.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzene Derivatives; 8Q54S3XE7K / cumene
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29. Rhodes MC, Bucher JR, Peckham JC, Kissling GE, Hejtmancik MR, Chhabra RS: Carcinogenesis studies of benzophenone in rats and mice. Food Chem Toxicol; 2007 May;45(5):843-51
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  • There was a positive trend in the incidence of renal tubule adenoma in male rats; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Increased incidences of mononuclear cell leukemia were observed in male rats exposed to 312 or 625 ppm benzophenone and in female rats exposed to 625 ppm benzophenone.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1250 ppm groups.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • The incidences of kidney nephropathy in exposed groups of female mice, as well as the severity of nephropathy in exposed groups of males, were significantly increased.
  • Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma.
  • There was equivocal evidence of carcinogenic activity of benzophenone in female F344/N rats based on the marginal increased incidences of mononuclear cell leukemia and histiocytic sarcoma.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F(1) mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F(1) mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F(1) mice may have been related to benzophenone exposure.
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Animals. Dose-Response Relationship, Drug. Female. Histiocytic Disorders, Malignant / chemically induced. Histiocytic Disorders, Malignant / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia / chemically induced. Leukemia / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Rats. Rats, Inbred F344. Sarcoma / chemically induced. Sarcoma / pathology. Sex Factors

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  • [Cites] J Am Acad Dermatol. 2003 Nov;49(5 Suppl):S259-61 [14576646.001]
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  • (PMID = 17187913.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
  • [Other-IDs] NLM/ NIHMS21944; NLM/ PMC1936973
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30. Herlitz LC, Tong GX, Hamele-Bena D, Greenebaum E: Nephrogenic adenoma identified on urine cytology using PAX-2 immunostaining. Diagn Cytopathol; 2008 Jan;36(1):47-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nephrogenic adenoma identified on urine cytology using PAX-2 immunostaining.
  • However, the cytologic features of nonneoplastic lesions of the lower urinary tract, including nephrogenic adenoma, are nonspecific and may cause false positive diagnosis.
  • Recent evidence has demonstrated that nephrogenic adenoma is a true "nephrogenic" lesion derived from the exfoliated and implanted renal tubular cells in the urinary tract.
  • This has promoted the use of immunostaining of renal transcription factor PAX2 in tissue biopsies to differentiate nephrogenic adenoma from the common malignant tumors of the lower urinary tract.
  • We report here that PAX2 immunostaining can also be used in urine cytology specimen to identify nephrogenic adenoma.
  • Combination of PAX2 immunostaining and cytologic analysis may increase the accuracy in identifying this benign lesion in urine cytology specimen and therefore reduce unnecessary repeat cystoscopy and biopsy procedures.
  • This may be a cost effective follow- up method for patients with an established diagnosis of nephrogenic adenoma.
  • [MeSH-major] Adenoma / diagnosis. PAX2 Transcription Factor / metabolism. Urinary Bladder Neoplasms / diagnosis. Urine / cytology
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Kidney Tubules / metabolism. Kidney Tubules / pathology

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  • (PMID = 18064687.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human
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31. Kim MS, Kim SK, Kim SI, Kim YS, Jeong HJ: Ureteral nephrogenic adenoma in a renal allograft patient. Int J Urol; 2008 Feb;15(2):178-9
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  • [Title] Ureteral nephrogenic adenoma in a renal allograft patient.
  • A 56-year-old male who had renal transplants at the age of 34 and 49 years, presented with painless gross hematuria six years after the second renal transplantation.
  • An abdominal computed tomography scan revealed diffuse wall thickening of the distal ureter of the failed first allograft and a bulging lesion about 1.2 cm in size on the lower pole of the right native kidney.
  • Both lesions were suspected for tumors, but they showed a ureteral nephrogenic adenoma and a renal hemorrhagic simple cyst.
  • [MeSH-major] Adenoma / diagnosis. Cysts / diagnosis. Hematuria / etiology. Kidney Diseases / diagnosis. Ureteral Neoplasms / diagnosis
  • [MeSH-minor] Humans. Kidney Transplantation. Male. Middle Aged

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  • (PMID = 18269460.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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32. Wolf A, Willenberg HS, Cupisti K, Schott M, Geddert H, Raffel A, Bornstein SR, Scherbaum WA, Knoefel WT: Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management. Horm Metab Res; 2005 Jun;37(6):391-5
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  • [Title] Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management.
  • To contribute to the studies of systemic interactions between these tissues, we studied a 52-year-old female patient with a pheochromocytoma and a contralateral cortisol-producing adenoma.
  • Due to a misunderstanding, she presented to her family doctor to have an inherited kidney disease ruled out.
  • Laboratory work-up, selective adrenal venous sampling and magnetic resonance imaging studies established the diagnosis of a pheochromocytoma in the right-hand adrenal gland and a cortisol-producing adenoma on the left.
  • Although presence of bilateral adrenal adenomas or bilateral adrenal pheochromocytomas in certain inherited disorders are possible, this rare case of an adrenal pheochromocytoma combined with a contralateral cortisol-producing adrenal adenoma may further underline the wide range of complex interactions between the two endocrine systems.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Pheochromocytoma / radiography

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  • (PMID = 16001333.001).
  • [ISSN] 0018-5043
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] WI4X0X7BPJ / Hydrocortisone
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33. Portugal R, Barroca H: Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour. Cytopathology; 2008 Apr;19(2):80-5
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  • [Title] Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour.
  • Wilms' Tumour (WT) is the most common kidney tumour in childhood, this fact and the embryonic complexity of WT create, whenever one of its three classical components predominates in cytologic smears, difficulties in the differential diagnoses with other less common entities.
  • In the present study, we review the cytological and immunohistochemical characteristics of three children renal tumours, a Clear Cell Sarcoma of the Kidney (CCSK-case1), a Cellular Mesoblastic Nephroma (CMN-case2) and a Metanephric Adenoma (MA-case3) and compare them, for differential diagnostic purposes, with smears of blastematous, mesenchymal and epithelial predominant WTs, previously diagnosed in our Department.
  • The presence of moderate amount of blue pale cytoplasm in neoplastic cells (case1), the presence of tightly cohesive, bland, spindle tumour cells (case2) and the identification of small, well differentiated epithelial tubules with psammoma bodies in case 3, were the main morphologic characteristics that we think represent the most important elements for distinguishing our cases from a WT.
  • Summing up, these three cases demonstrate that cytopathologists should be aware of the occurrence of uncommon renal neoplasms in childhood and should be acquainted with their characteristics, in order to avoid false diagnoses.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology. Sarcoma, Clear Cell / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Biopsy, Fine-Needle. Child. Child, Preschool. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Inclusion Bodies / chemistry. Inclusion Bodies / pathology. Infant, Newborn. Male. Pregnancy

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  • (PMID = 17681013.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Paner GP, Turk TM, Clark JI, Lindgren V, Picken MM: Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes. Arch Pathol Lab Med; 2005 Oct;129(10):1317-21
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  • [Title] Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes.
  • However, rarely, inconsequential passive transport of benign neoplastic cells to the lymph node can occur and may cause confusion as to the nature of the neoplasm (ie, malignant vs benign).
  • We describe a 10-cm right renal metanephric adenoma incidentally discovered in a 30-year-old woman during cesarean section for a triplet pregnancy.
  • Subsequent nephrectomy following an equivocal needle biopsy diagnosis showed histologic features classic for metanephric adenoma, including the lack of cytologic atypia and mitoses.
  • The tumor proliferation index with Ki-67 was only 3% to 5% and the proliferating cell nuclear antigen index was 0%.
  • We postulate that the lymph node inclusions found in this case represent passive transport of neoplastic cells to the lymph node following manipulation of the renal mass.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Lymph Nodes / pathology. Neoplasm Seeding
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Cytogenetic Analysis. Diagnosis, Differential. Female. Humans. Kidney / pathology. Neoplasm Metastasis / diagnosis. Pregnancy. Wilms Tumor / diagnosis

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  • (PMID = 16196523.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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35. Szponar A, Yusenko MV, Kovacs G: High-resolution array CGH of metanephric adenomas: lack of DNA copy number changes. Histopathology; 2010 Jan;56(2):212-6
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  • [Title] High-resolution array CGH of metanephric adenomas: lack of DNA copy number changes.
  • AIMS: Previous karyotyping and fluorescence in situ hybridization analysis of metanephric adenomas (MAs) has yielded controversial data.
  • METHODS AND RESULTS: DNA extracted from paraffin blocks of six metanephric adenomas was hybridized onto Agilent oligoarrays with approximately 43,000 in situ synthesized 60-mer oligonucleotide probes that span coding and non-coding sequences with an average spatial resolution of approximately 35 kb.
  • None of the metanephric adenomas showed DNA copy number changes.
  • To confirm our results, DNA extracted from the paraffin block of a chromophobe renal cell carcinoma (RCC) was simultaneously hybridized to one of the four arrays on the same slides as an internal control.
  • CONCLUSIONS: Our high-resolution oligoarray analysis indicates that metanephric adenomas lack DNA copy number alterations.
  • This finding may help to differentiate between metanephric adenomas from Wilms' tumour and papillary renal cell adenoma with overlapping phenotype.
  • [MeSH-major] Adenoma / genetics. DNA Copy Number Variations. Kidney Neoplasms / genetics
  • [MeSH-minor] Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Comparative Genomic Hybridization. Humans

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  • (PMID = 20102400.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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36. Liu H, Yamaki T, Oka S, Koyanagi I, Houkin K: Metastatic renal cell carcinoma mimicking pituitary adenoma: case report. Neurol Med Chir (Tokyo); 2005 Aug;45(8):418-22
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  • [Title] Metastatic renal cell carcinoma mimicking pituitary adenoma: case report.
  • A 54-year-old man, with a past history of renal cell carcinoma, presented with bitemporal visual field defect, hyponatremia, and diabetes insipidus.
  • The initial radiological impression was pituitary adenoma.
  • Histological examination revealed metastatic renal cell carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Neoplasm, Residual / secondary. Pituitary Gland / pathology. Pituitary Neoplasms / secondary. Prolactinoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Hypopituitarism / etiology. Hypopituitarism / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Radiotherapy. Sella Turcica / pathology. Sella Turcica / radiography. Sella Turcica / surgery. Treatment Outcome


37. Jalpota Y, Tewari V, Madan R: Recurrent nephrogenic adenoma of urinary bladder in a renal allograft recipient--a case report. Indian J Pathol Microbiol; 2006 Apr;49(2):261-3
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  • [Title] Recurrent nephrogenic adenoma of urinary bladder in a renal allograft recipient--a case report.
  • Nephrogenic adenoma is a rare benign tumour-like lesion within the urothelial mucosa of the urinary tract.
  • It may be an incidental finding in bladder of a patient presenting with haematuria, dysuria and bladder growth after renal allograft transplant.
  • Definite diagnosis is established by histological examination of tumor.
  • Though it attains an extensive spread in bladder mucosa and has a high tendency to recur, the clinical course is benign.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms. Neoplasm Recurrence, Local / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans

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  • (PMID = 16933732.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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38. McNeil JC, Corbett ST, Kuruvilla S, Jones EA: Metanephric adenoma in a five-year-old boy presenting with chyluria: case report and review of literature. Urology; 2008 Sep;72(3):545-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metanephric adenoma in a five-year-old boy presenting with chyluria: case report and review of literature.
  • Metanephric adenoma and chyluria are rare entities, especially in the pediatric population of North America.
  • To date, no report of chyluria associated with metanephric adenoma has been published.
  • [MeSH-major] Adenoma / complications. Adenoma / diagnosis. Kidney Neoplasms / complications. Kidney Neoplasms / diagnosis. Urinary Bladder Diseases / complications. Urinary Bladder Diseases / diagnosis. Urology / methods
  • [MeSH-minor] Child. Comorbidity. Humans. Male. Nevus / complications. Nevus / diagnosis. Pediatrics / methods. Treatment Outcome

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  • (PMID = 18602139.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Sornmayura P, Siripornpitak S, Leela-udomlipi S, Bunyaratvej S: Hepatocellular adenoma: a case report. J Med Assoc Thai; 2010 Mar;93(3):393-7
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  • [Title] Hepatocellular adenoma: a case report.
  • A case of hepatocellular adenoma (HCA) was described in a 26-year-old woman, who was a potential kidney donor for her father and denied taking the oral contraceptive pill.
  • [MeSH-major] Adenoma, Liver Cell / diagnosis. Liver Neoplasms / diagnosis

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  • (PMID = 20420118.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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40. Sawazaki H, Segawa T, Yoshida K, Kawahara T, Inoue T, Soda T, Kamba T, Yoshimura K, Takahashi T, Nakamura E, Nishiyama H, Ito N, Kamoto T, Ogawa O: [Hemorrhagic adrenocortical adenoma with myelolipoma: a case report]. Hinyokika Kiyo; 2006 Oct;52(10):785-8
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  • [Title] [Hemorrhagic adrenocortical adenoma with myelolipoma: a case report].
  • We present a case of hemorrhagic adrenocortical adenoma with myelolipoma.
  • Based on abdominal computed tomography, magnetic resonance imaging and blood tests, preoperative diagnosis was a sarcoma of renal capsule origin.
  • En bloc resection of adrenal gland, tumor, and the kidney with lymph node dissection was performed.
  • Histologically, the mass was diagnosed as hemorrhagic adrenocortical adenoma with myelolipomatous foci.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenal Gland Neoplasms / etiology. Adrenocortical Adenoma / complications. Myelolipoma / etiology. Neoplasms, Multiple Primary

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  • (PMID = 17131868.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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41. Amodio JB, Shapiro E, Pinkney L, Rivera R, Strubel N, Douglas D, Fefferman N: Metanephric adenoma in an 8-year-old child: case report and review of the literature. J Pediatr Surg; 2005 May;40(5):e25-8
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  • [Title] Metanephric adenoma in an 8-year-old child: case report and review of the literature.
  • Metanephric adenoma (MA) is a renal tumor that is rarely found in children.
  • There are certain imaging features of MA that may suggest the diagnosis preoperatively.
  • Metanephric adenoma is often hyperechoic on sonography, hyperdense on noncontrast computed tomography scans, and of low signal intensity on T1- and T2-weighted magnetic resonance images.
  • However, the distinction of MA from other metanephric lesions as well as from Wilms' tumor and papillary renal cell carcinoma may not be readily apparent at the time of surgery.
  • [MeSH-major] Adenoma / surgery. Kidney Neoplasms / surgery
  • [MeSH-minor] Appendicitis / radiography. Carcinoma, Renal Cell / diagnosis. Child. Diagnosis, Differential. Female. Humans. Incidental Findings. Magnetic Resonance Imaging. Nephrectomy. Tomography, X-Ray Computed. Wilms Tumor / diagnosis

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  • (PMID = 15937802.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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42. Morrissey JJ, London AN, Luo J, Kharasch ED: Urinary biomarkers for the early diagnosis of kidney cancer. Mayo Clin Proc; 2010 May;85(5):413-21
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  • [Title] Urinary biomarkers for the early diagnosis of kidney cancer.
  • OBJECTIVE: To test the hypothesis that increased tumor expression of proteins such as aquaporin-1 (AQP1) and adipophilin (ADFP) in patients with renal cancer would result in increased urine AQP1 and ADFP excretion.
  • PATIENTS AND METHODS: Prenephrectomy and postnephrectomy (pseudocontrol) urine samples were collected from 42 patients with an incidental radiographically discovered renal mass and presurgical presumptive diagnosis of kidney cancer from July 8, 2008, through March 10, 2009.
  • RESULTS: Mean +/- SD preexcision urine AQP1 and ADFP concentrations (76+/-29 and 117+/-74 arbitrary units, respectively) in patients with a pathologic diagnosis of clear cell (n=22) or papillary (n=10) cancer were significantly greater than in patients with renal cancer of nonproximal tubule origin, control surgical patients, and healthy volunteers (combined values of 0.1+/-0.1 and 1.0+/-1.6 arbitrary units, respectively; n=44; P<.001).
  • The AQP1 and ADFP concentrations decreased 88% to 97% in the 25 patients with clear cell or papillary cancer who provided postnephrectomy follow-up urine samples.
  • In patients with clear cell and papillary carcinoma, a linear correlation (Spearman) was found between tumor size and preexcision urine AQP1 or ADFP concentration (r=0.82 and 0.76, respectively; P<.001 for each).
  • CONCLUSION: Urine AQP1 and ADFP concentrations appear to be sensitive and specific biomarkers of kidney cancers of proximal tubule origin.
  • These biomarkers may be useful to diagnose an imaged renal mass and screen for kidney cancer at an early stage.
  • [MeSH-major] Aquaporin 1 / urine. Biomarkers, Tumor / urine. Kidney Neoplasms / diagnosis. Peptides / urine
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / urine. Blotting, Western. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / urine. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / urine. Creatinine / urine. Female. Humans. Male. Membrane Proteins. Middle Aged. Nephrectomy. Perilipin-2. Prospective Studies. ROC Curve

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  • (PMID = 20375178.001).
  • [ISSN] 1942-5546
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00851994
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Membrane Proteins; 0 / PLIN2 protein, human; 0 / Peptides; 0 / Perilipin-2; 146410-94-8 / Aquaporin 1; AYI8EX34EU / Creatinine
  • [Other-IDs] NLM/ PMC2861969
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43. Inoue K, Shibutani M, Masutomi N, Toyoda K, Takagi H, Takahashi M, Fujimoto H, Hirose M, Nishikawa A: One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver. Food Chem Toxicol; 2008 Oct;46(10):3303-10
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  • [Title] One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver.
  • Relative weights of the liver were significantly increased from 1.0% in both sexes, and those of the kidney were significantly increased from 1.0% in males and from 0.2% in females.
  • Histopathologically, atypical renal tubule hyperplasias were increased at 1.0% or higher in both sexes in association with increase of cell proliferative activity in the tubules.
  • A renal cell adenoma was observed in a male rat receiving 5.0% MC.
  • In addition, glutathione S-transferase placental form-positive liver cell foci were significantly increased at 5.0% in both sexes.
  • These results indicate that MC has chronic toxicity targeting kidney, liver and blood cells.
  • Moreover, the results strongly suggest that MC may have the carcinogenic potential in the kidney and the liver.
  • [MeSH-major] Kidney Neoplasms / chemically induced. Liver Neoplasms / chemically induced. Plant Extracts / administration & dosage. Plant Extracts / toxicity. Precancerous Conditions / chemically induced. Rubia / toxicity
  • [MeSH-minor] Animals. Cell Proliferation. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Kidney / cytology. Male. Rats. Rats, Inbred F344. Toxicity Tests, Chronic

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  • (PMID = 18723070.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Extracts; 0 / madder color
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44. Pacchioni D, Volante M, Casetta G, Sapino A, Marchiò C, Bussolati G: Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case. Am J Surg Pathol; 2007 Apr;31(4):632-6
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  • [Title] Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case.
  • We herein report an unusual case of a low-grade myxoid renal epithelial neoplasm, with peculiar and previously unreported morphologic and immunohistochemical features.
  • These were lined by 2 different epithelial cell types, flat and elongated basal cells and cuboidal to spindle shaped eosinophilic luminal cells, with low-grade nuclear features and a few small nucleoli.
  • The lesion morphologically resembled a pleomorphic adenoma of the salivary gland.
  • The tumor proved benign at follow-up.
  • [MeSH-major] Kidney Neoplasms / pathology. Myoepithelioma / pathology. Neoplasms, Glandular and Epithelial / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Salivary Gland Neoplasms / pathology

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  • (PMID = 17414112.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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45. Küpeli S, Baydar DE, Canakl F, Yalçn B, Kösemehmetoğlu K, Tekgül S, Büyükpamukçu M: Metanephric adenoma in a 6-year-old child with hemihypertrophy. J Pediatr Hematol Oncol; 2009 Jun;31(6):453-5
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  • [Title] Metanephric adenoma in a 6-year-old child with hemihypertrophy.
  • Metanephric adenoma (MA) is a renal tumor that is rarely diagnosed in children.
  • Although it is considered benign and to have a good prognosis, the diagnosis of MA is challenging because of histopathologic and radiologic similarities to Wilms tumor.
  • In this case report, we present a 6-year-old girl, with a renal mass and right hemihypertrophy, who was previously diagnosed as Wilms tumor on a fine-needle biopsy and diagnosed as MA after nephroureterectomy.
  • The differentiation between Wilms tumor and metanephric adenoma is also discussed.
  • [MeSH-major] Adenoma / pathology. Biopsy, Fine-Needle. Kidney Neoplasms / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Diagnostic Errors. Female. Humans. Immunohistochemistry. Nephrectomy. Ureter / surgery

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  • (PMID = 19648796.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Tian L, Guo Y, Wu YP, Liu LZ: [CT features of adrenal cortical adenoma: a report of 109 cases]. Ai Zheng; 2008 Jan;27(1):66-70

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  • [Title] [CT features of adrenal cortical adenoma: a report of 109 cases].
  • BACKGROUND & OBJECTIVE: Adrenal cortical adenoma (ACA) is a common disease, and can be diagnosed easily with CT examination.
  • However, some atypical adenomas are likely to be misdiagnosed.
  • RESULTS: Of the 109 cases of ACA, 104 showed unilateral single adenoma, 1 showed unilateral 2 adenomas, and 4 showed bilateral adenomas.
  • The maximal diameter of non-functional adenomas was larger than that of Cushing's adenomas, and the latter was larger than that of Conn's adenomas.
  • The probability of degeneration was higher in large adenomas than in small adenomas.
  • Two patients had recurrence after operation: 1 showed infiltration in the adjacent kidney and the psoas major on pathologic examination, 1 showed infiltration in the liver and thoracic vertebra on CT images.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Radiographic Image Enhancement / methods. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Neoplasm Recurrence, Local. Tumor Burden. Young Adult

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  • (PMID = 18184467.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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47. Mahadevia S, Rozenblit A, Milikow D, Marinovich A: Renal-adrenal fusion: instance of an adrenal adenoma mimicking a solid renal mass at CT--case report. Radiology; 2009 Jun;251(3):808-12
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  • [Title] Renal-adrenal fusion: instance of an adrenal adenoma mimicking a solid renal mass at CT--case report.
  • The authors report an unusual case of unilateral renal-adrenal fusion with a concurrent adrenal adenoma.
  • At computed tomography, this abnormality appeared as a solid enhancing lesion in the upper pole of the kidney, mimicking a renal mass.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenocortical Adenoma / radiography. Kidney / abnormalities. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Kidney Diseases / radiography. Nephrectomy

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  • (PMID = 19261923.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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48. Kojima Y, Miyake O, Morimoto A, Kawamura C, Katayama S: [A case of aldosterone-producing adenoma associated with end-stage renal disease]. Hinyokika Kiyo; 2010 Jan;56(1):21-4
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  • [Title] [A case of aldosterone-producing adenoma associated with end-stage renal disease].
  • Periodic follow-up abdominal ultrasonography revealed a tumor measuring 4 cm in diameter in an area adjacent to the upper pole of the right kidney.
  • Under a diagnosis of aldosterone-producing adrenal tumor, laparoscopic right adrenalectomy was performed.
  • Pathological findings showed adrenal cortical adenoma.
  • A previous study also indicated the presence of hyperaldosteronemia in patients with end-stage renal disease.
  • A diagnosis should be carefully made.
  • [MeSH-major] Adenoma / complications. Adrenal Gland Neoplasms / complications. Aldosterone / biosynthesis. Kidney Failure, Chronic / complications

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  • (PMID = 20104005.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; RWP5GA015D / Potassium
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49. Fulciniti F, Losito NS, Botti G, Manola M, Ionna F: Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample. Diagn Cytopathol; 2010 Jun;38(6):430-4

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  • [Title] Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.
  • Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine-needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney.
  • One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Adenoma, Pleomorphic / pathology. Infarction / pathology. Parotid Neoplasms / blood supply. Parotid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle / adverse effects. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19894261.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Patel NP, Geisinger KR, Zagoria RJ, Bergman S: Fine needle aspiration biopsy of metanephric adenoma: a case report. Acta Cytol; 2009 May-Jun;53(3):327-31
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  • [Title] Fine needle aspiration biopsy of metanephric adenoma: a case report.
  • BACKGROUND: Metanephric adenoma (MA) is a rare, benign renal neoplasm.
  • Regarding treatment, radioflrequency ablation (RFA) is an emerging alternative to surgical resection of renal neoplasms in appropriately selected patients.
  • CASE: A 49-year-old woman had a 3.3-cm cortical mass in the left kidney.
  • The aspirate smears displayed multiple aggregates of benign-appearing, tightly packed and overlapping nuclei surrounded by basement membrane- type material.
  • Although the differential diagnosis included adult Wilms' tumor and papillary renal cell carcinoma, the bland morphology and IHC staining pattern strongly favored a neoplasm consistent with MA.
  • CONCLUSION: FNAB can be used to diagnose most renal neoplasms.
  • A diagnosis of MA can be suggested on FNAB in the context of appropriate cytomorphology, IHC staining and cytogenetic analysis.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, CD57 / analysis. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Catheter Ablation / methods. Diagnosis, Differential. Female. Humans. Middle Aged. Minimally Invasive Surgical Procedures. Treatment Outcome. WT1 Proteins / analysis. Wilms Tumor / diagnosis

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  • (PMID = 19534278.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / WT1 Proteins
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51. Vieira J, Henrique R, Ribeiro FR, Barros-Silva JD, Peixoto A, Santos C, Pinheiro M, Costa VL, Soares MJ, Oliveira J, Jerónimo C, Teixeira MR: Feasibility of differential diagnosis of kidney tumors by comparative genomic hybridization of fine needle aspiration biopsies. Genes Chromosomes Cancer; 2010 Oct;49(10):935-47
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  • [Title] Feasibility of differential diagnosis of kidney tumors by comparative genomic hybridization of fine needle aspiration biopsies.
  • The association of a genetic analysis that could improve the diagnostic accuracy of renal cell tumors in biopsy samples would allow better-informed therapeutic decisions.
  • We performed comparative genomic hybridization (CGH) on an ex vivo fine-needle aspiration (FNA) biopsy and a tumor fragment obtained from 75 patients consecutively diagnosed with renal tumors and subjected to radical nephrectomy.
  • The pattern of genomic changes by CGH was used blindly to classify the renal tumors and the genetic findings were subsequently compared with the histopathologic diagnosis.
  • CGH was successful in 82.7% FNA biopsies and in 96% tumor fragments, with the former allowing genetic diagnosis in 75% of renal cell tumors.
  • The genetic and the initial histological classification differed in two renal neoplasias, but the genetic diagnosis was confirmed after review.
  • The genetic pattern correctly diagnosed 93.5% of clear cell renal cell carcinomas (RCC), 61.5% of chromophobe RCC, 100% of papillary RCC, and 14.3% of oncocytomas, with the negative predictive value being 93.9, 90.7, 100, and 90.2%, respectively.
  • We demonstrate that genetic diagnosis by CGH on FNA biopsies can improve differential diagnosis in patients with kidney tumors.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Chromosomes, Human / genetics. Comparative Genomic Hybridization. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. DNA Methylation. Diagnosis, Differential. Exons / genetics. Feasibility Studies. Humans. In Situ Hybridization, Fluorescence. Neoplasm Staging. Nephrectomy. Oligonucleotide Array Sequence Analysis. Point Mutation / genetics. Prognosis. Promoter Regions, Genetic. Survival Rate. Von Hippel-Lindau Tumor Suppressor Protein / genetics

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  • (PMID = 20629095.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 6.3.2.19 / VHL protein, human; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
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52. Kahveci A, Ari E, Arikan H, Koc M, Tuglular S, Ozener C: Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient. Hemodial Int; 2010 Jan;14(1):91-3
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  • [Title] Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient.
  • Abstract We report the case of a 54-year-old hemodialysis patient who presented with recurrent fever due to Streptococcus bovis bacteremia related to colonic tubulovillous adenoma.
  • In this paper, we discussed the relation between S. bovis bacteremia, colonic adenomas, and hemodialysis.
  • Awareness of this association is critical for early diagnosis and management.
  • [MeSH-major] Adenoma / microbiology. Bacteremia / etiology. Colonic Neoplasms / microbiology. Kidney Failure, Chronic / therapy. Renal Dialysis / adverse effects. Streptococcal Infections / pathology. Streptococcus bovis / isolation & purification

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  • (PMID = 19758303.001).
  • [ISSN] 1542-4758
  • [Journal-full-title] Hemodialysis international. International Symposium on Home Hemodialysis
  • [ISO-abbreviation] Hemodial Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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53. Sanders JM, Bucher JR, Peckham JC, Kissling GE, Hejtmancik MR, Chhabra RS: Carcinogenesis studies of cresols in rats and mice. Toxicology; 2009 Mar 4;257(1-2):33-9
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  • A marginally increased incidence of renal tubule adenoma was observed in the 15,000-ppm-exposed rats.
  • No increased incidence of hyperplasia of the renal tubules was observed; however, a significantly increased incidence of hyperplasia of the transitional epithelium associated with an increased incidence of nephropathy was observed at the high exposure concentration.
  • The only significantly increased incidence of a neoplastic lesion related to cresol exposure observed in these studies was that of squamous cell papilloma in the forestomach of 10,000-ppm-exposed mice.
  • [MeSH-major] Carcinogenicity Tests. Carcinogens / toxicity. Cresols / toxicity. Kidney Neoplasms / pathology. Neoplasms / chemically induced
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Animals. Body Weight / drug effects. Dose-Response Relationship, Drug. Eating / drug effects. Female. Gastric Mucosa / drug effects. Gastric Mucosa / pathology. Kidney Tubules / drug effects. Kidney Tubules / pathology. Male. Mice. Papilloma / chemically induced. Papilloma / pathology. Rats. Rats, Inbred F344. Stomach Neoplasms / chemically induced. Stomach Neoplasms / pathology. Time Factors

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  • (PMID = 19114085.001).
  • [ISSN] 0300-483X
  • [Journal-full-title] Toxicology
  • [ISO-abbreviation] Toxicology
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Cresols
  • [Other-IDs] NLM/ NIHMS104529; NLM/ PMC2826171
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54. National Toxicology Program: Toxicology and carcinogenesis studies of methyl isobutyl ketone (Cas No. 108-10-1) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2007 Feb;(538):1-236
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  • In the standard evaluation of the kidney, there were slightly increased incidences of renal tubule adenoma and renal tubule adenoma or carcinoma (combined) in males exposed to 900 or 1,800 ppm, and renal tubule carcinoma in males exposed to 1,800 ppm.
  • The incidences of renal tubule hyperplasia were also significantly increased in the 450 and 1,800 ppm males, and the severities were greater than in the chamber controls.
  • The incidences of transitional epithelial hyperplasia of the renal pelvis in males exposed to 900 or 1,800 ppm and mineralization of the renal papilla in all groups of exposed males were significantly increased.
  • In addition, two female rats exposed to 1,800 ppm had renal mesenchymal tumors.
  • In the extended evaluation of the kidney, renal tubule adenomas and renal tubule hyperplasia occurred in all groups of exposed male rats.
  • In the combined single and step section analysis, the incidences of renal tubule adenoma and renal tubule adenoma or carcinoma (combined) were significantly increased in males exposed to 1,800 ppm.
  • The incidences of renal tubule hyperplasia were also significantly increased in all exposed groups of males.
  • There was a positive trend in the incidences of mononuclear cell leukemia in males, and the incidence in the 1,800 ppm group was significantly increased.
  • The incidences of hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined) were significantly increased in males and females exposed to 1,800 ppm.
  • CONCLUSIONS: Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of methyl isobutyl ketone in male F344/N rats based on increased incidences of renal tubule neoplasms.
  • Increased incidences of mononuclear cell leukemia in 1,800 ppm male F344/N rats may have been related to methyl isobutyl ketone exposure.
  • There was equivocal evidence of carcinogenic activity of methyl isobutyl ketone in female F344/N rats based on the occurrence of renal mesenchymal tumors in the 1,800 ppm group.
  • Exposure to methyl isobutyl ketone resulted in nonneoplastic lesions of the kidney characteristic of alpha2u-globulin accumulation in male rats and nephropathy in female rats.
  • [MeSH-minor] Administration, Oral. Adrenal Glands / drug effects. Animals. Body Weight / drug effects. Female. Kidney / drug effects. Kidney / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia, Myeloid / chemically induced. Leukemia, Myeloid / pathology. Liver / drug effects. Liver / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Lung Neoplasms / chemically induced. Lung Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Occupational Exposure. Rats. Rats, Inbred F344. Water Supply

  • Hazardous Substances Data Bank. METHYL ISOBUTYL KETONE .
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  • (PMID = 17557116.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Environmental Pollutants; 0 / Solvents; 6QDY60NH6N / Methyl n-Butyl Ketone; U5T7B88CNP / methyl isobutyl ketone
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55. Lunn MR, Muñoz Mendoza J, Pasche LJ, Norton JA, Ayco AL, Chertow GM: Hyperparathyroidism with hypercalcaemia in chronic kidney disease: primary or tertiary? NDT Plus; 2010 Aug;3(4):366-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperparathyroidism with hypercalcaemia in chronic kidney disease: primary or tertiary?
  • Objective . This study aims to highlight the challenges in the diagnosis of hyperparathyroidism (HPT) in patients with advanced chronic kidney disease (CKD).
  • Results . Evaluation confirmed the presence of a large parathyroid adenoma; HPT and hypercalcaemia resolved rapidly following resection.
  • Conclusion . This case report is remarkable for its severe hypercalcaemia requiring haemodialysis, large adenoma size, acute-on-chronic kidney injury and markedly elevated PTH concentration in association with primary HPT in CKD.

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  • (PMID = 25949433.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / K24 DK085446
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4421527
  • [Keywords] NOTNLM ; PTH / parathyroid adenoma / parathyroid hormone / primary hyperparathyroidism / tertiary hyperparathyroidism
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56. Admassie D, Negusie Y, Yeshaw T: A case of primary hyperparathyrodism due to parathyroid adenoma Doppler ultrasound diagnosis. Ethiop Med J; 2006 Oct;44(4):391-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of primary hyperparathyrodism due to parathyroid adenoma Doppler ultrasound diagnosis.
  • Bone and kidney are target organs of the disease (1).
  • Serum calcium, alkaline phosphatase and creatinine were elevated X-rays show renal stone, bone resorption and brown tumor.
  • [MeSH-major] Adenoma / complications. Adenoma / ultrasonography. Hyperparathyroidism, Primary / etiology. Parathyroid Neoplasms / complications. Parathyroid Neoplasms / ultrasonography. Ultrasonography, Doppler
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17370440.001).
  • [ISSN] 0014-1755
  • [Journal-full-title] Ethiopian medical journal
  • [ISO-abbreviation] Ethiop. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ethiopia
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57. Amar L, Plouin PF, Steichen O: Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism. Orphanet J Rare Dis; 2010;5:9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism.
  • Unilateral aldosterone hypersecretion is caused by an aldosterone-producing adenoma (also known as Conn's adenoma and aldosteronoma), primary unilateral adrenal hyperplasia and rare cases of aldosterone-producing adrenocortical carcinoma.
  • Its prevalence in referred hypertensive populations is estimated to be between 6 and 13%, of which 1.5 to 5% have an aldosterone-producing adenoma or primary unilateral adrenal hyperplasia.
  • The differential diagnosis of hypokalemic hypertension with low renin includes mineralocorticoid excess, with the mineralocorticoid being cortisol or 11-deoxycorticosterone, apparent mineralocorticoid excess, pseudo-hypermineralocorticoidism in Liddle syndrome or exposure to glycyrrhizic acid.
  • Once the diagnosis is confirmed, adrenal computed tomography is performed for all patients.
  • [MeSH-major] Adrenocortical Adenoma / diagnosis. Adrenocortical Adenoma / metabolism. Aldosterone / metabolism. Hyperaldosteronism / diagnosis. Hyperaldosteronism / surgery

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  • (PMID = 20482833.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
  • [Number-of-references] 83
  • [Other-IDs] NLM/ PMC2889888
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58. Merante-Boschin I, Fassan M, Pelizzo MR, Ide EC, Rugge M: Neck emergency due to parathyroid adenoma bleeding: a case report. J Med Case Rep; 2009;3:7404
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neck emergency due to parathyroid adenoma bleeding: a case report.
  • INTRODUCTION: The spontaneous rupture of a parathyroid adenoma accompanied by extracapsular hemorrhage is a rare, potentially fatal, condition and is a cervicomediastinal surgical emergency.
  • CASE PRESENTATION: This report describes an atypical two-step spontaneous rupture of an asymptomatic parathyroid adenoma in a 56-year-old Caucasian woman who presented with a painful mass in the right side of her neck.
  • CONCLUSION: Based on this case report and similar cases reported in the medical literature, a diagnosis of extracapsular parathyroid hemorrhage should be considered when a non-traumatic sudden neck swelling coexists with hypercalcemia and regional ecchymosis.

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  • (PMID = 19830200.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2726549
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59. Lin YT, Chang CH, Chen WC: Asymptomatic congenital splenorenal shunt in a noncirrhotic patient with a left adrenal aldosterone-producing adenoma. Kaohsiung J Med Sci; 2009 Dec;25(12):669-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Asymptomatic congenital splenorenal shunt in a noncirrhotic patient with a left adrenal aldosterone-producing adenoma.
  • Here, we present a case of a venous shunt between the spleen and left renal vein in a 57-year-old man with no history of liver cirrhosis, portal hypertension, or hepatic encephalopathy.
  • The abnormal vessel was identified on preoperative contrast-enhanced computed tomography performed for diagnosis of a left adrenal aldosterone-producing adenoma.
  • [MeSH-major] Adenoma / metabolism. Adrenal Gland Neoplasms / metabolism. Aldosterone / biosynthesis. Kidney / blood supply. Spleen / blood supply

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  • (PMID = 19951853.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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60. D'Antonio A, Caleo A, Caleo O, Addesso M, Boscaino A: Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma. Hepatobiliary Pancreat Dis Int; 2010 Oct;9(5):550-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma.
  • BACKGROUND: Renal metastases of hepatocellular carcinoma (HCC) are very rare.
  • METHODS: We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of disease.
  • The patient was a 54-year-old woman previously submitted to orthotopic liver transplantation, who underwent left nephrectomy for a renal mass.
  • RESULTS: Histologically, the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features.
  • A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin 1.
  • CONCLUSIONS: Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with HCC.
  • Since HCC may histologically resemble primary renal tumors such as oncocytoma, pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant drugs.
  • Immunohistochemistry is particularly helpful to establish a precise diagnosis in cases of doubt.
  • [MeSH-major] Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / secondary. Liver Neoplasms / diagnosis. Liver Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Diagnosis, Differential. Fatal Outcome. Female. Humans. Liver Transplantation / pathology. Middle Aged. Neoplasm Metastasis

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  • (PMID = 20943467.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] Oncocytoma, renal
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61. Liu W, Tretiakova M, Kong J, Turkyilmaz M, Li YC, Krausz T: Expression of vitamin D3 receptor in kidney tumors. Hum Pathol; 2006 Oct;37(10):1268-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of vitamin D3 receptor in kidney tumors.
  • The kidney is not only a primary vitamin D target organ but also is a key site of vitamin D metabolism.
  • Recent studies have shown that vitamin D has important physiologic effects on proliferation and differentiation in a variety of benign and malignant cells.
  • Our preliminary immunohistochemical study showed that vitamin D receptor (VDR) was highly expressed in renal distal tubules and collecting ducts, whereas the renal proximal tubules and glomeruli did not express VDR.
  • These observations led us to study the expression of VDR in various kidney tumors to determine the possible diagnostic utility of VDR.
  • Paraffin tissue microarray (TMA) blocks were constructed containing core cylinders from clear cell (52), papillary (35), chromophobe (20), sarcomatoid (20), and metastatic (59) renal cell carcinomas (RCCs).
  • In addition, 30 clear cell RCCs and 3 collecting duct carcinomas were also studied using conventional sections.
  • In contrast, VDR expression was focal/weak and present only in the peripheral regions of clear cell RCCs.
  • Overall, VDR is a discriminative marker for renal cell tumors.
  • In addition, the focal and much weaker VDR expression in clear cell RCCs makes VDR valuable in distinguishing clear cell RCC from other types of RCCs.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Receptors, Calcitriol / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Gene Expression. Humans. Immunoenzyme Techniques. Male. Middle Aged. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tissue Array Analysis

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  • (PMID = 16949927.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Receptors, Calcitriol
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62. Neuzillet Y, Lay F, Luccioni A, Daniel L, Berland Y, Coulange C, Lechevallier E: De novo renal cell carcinoma of native kidney in renal transplant recipients. Cancer; 2005 Jan 15;103(2):251-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] De novo renal cell carcinoma of native kidney in renal transplant recipients.
  • BACKGROUND: The 10-year risk of developing a solid malignancy is 20% for kidney transplant recipients.
  • The goal of the current study was to investigate the epidemiology and the diagnostic and prognostic parameters associated with de novo malignancies of the native kidney among transplant recipients at the authors' institution (Department of Urology and Renal Transplantation, Hôpital Salvator, Marseille, France).
  • All de novo malignancies of the native kidney were included in the current analysis.
  • RESULTS: Among the 933 patients examined, a combined total of 12 malignancies of the native kidney were diagnosed in 11 individuals.
  • For these 11 individuals, the average ages at transplantation and diagnosis were 42.5 and 49.1 years, respectively.
  • Among the 10 renal echographies performed, there was 1 false-negative result.
  • Among the 12 kidney malignancies encountered in the current study, there were 7 conventional cell carcinomas, 3 basophilic papillary carcinomas, and 2 chromophobic renal cell carcinomas.
  • Two affected transplant recipients died (one due to disease), and the remaining nine are alive without recurrence and with normal renal functioning (median follow-up, 39 months).
  • CONCLUSIONS: There appears to be an increased risk of malignancy of the native kidney in renal transplant recipients, with high-grade and papillary tumors being particularly common.
  • Consequently, systematic radiologic follow-up of native kidneys must be performed for individuals who undergo kidney transplantation.
  • [MeSH-major] Carcinoma, Renal Cell / epidemiology. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / epidemiology. Kidney Neoplasms / surgery. Kidney Transplantation / statistics & numerical data. Neoplasms, Second Primary / epidemiology
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / epidemiology. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / epidemiology. Adult. Age Distribution. Cohort Studies. Cystadenoma / diagnosis. Cystadenoma / epidemiology. Female. France / epidemiology. Humans. Incidence. Male. Middle Aged. Prognosis. Retrospective Studies. Risk Assessment. Sex Distribution. Survival Analysis. Tomography, X-Ray Computed

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  • [Copyright] (c) 2004 American Cancer Society.
  • (PMID = 15593084.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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63. Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser; 2006 Feb;(533):1-264
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  • There was a positive trend in the incidences of renal tubule adenoma in males, and the incidences in 625 and 1,250 ppm males exceeded the historical control range for all routes; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Due to these findings, additional kidney sections were evaluated; results indicated additional renal tubule adenomas in all groups of males and renal tubule hyperplasia in all groups of males and females.
  • Increased incidences of mononuclear cell leukemia in all exposed groups of females exceeded the historical control range from feed studies, and the incidence in 625 ppm females was significantly greater than that in the controls.
  • Male rats exposed to 312 or 625 ppm had significantly increased incidences of mononuclear cell leukemia.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups, and these incidences exceeded the historical control range.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • The incidences of kidney nephropathy and mineralization in exposed groups of females and the severity of nephropathy in exposed groups of males were significantly increased.
  • CONCLUSIONS: Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma; mononuclear cell leukemia in male F344/N rats may have been related to benzophenone exposure.
  • There was equivocal evidence of carcinogenic activity of benzophenone in female F344/N rats based on the marginally increased incidences of mononuclear cell leukemia and histiocytic sarcoma.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F1 mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F1 mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F1 mice may have been related to benzophenone exposure.
  • Administration of benzophenone in feed resulted in increased incidences and/or severities of nonneoplastic lesions in the kidney and liver of male and female rats and in the liver, kidney, nose, and spleen of male and female mice.
  • [MeSH-minor] Animals. Body Weight / drug effects. Carcinogenicity Tests. Dose-Response Relationship, Drug. Female. Histiocytic Disorders, Malignant / chemically induced. Histiocytic Disorders, Malignant / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia / chemically induced. Leukemia / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Longevity / drug effects. Male. Mice. Mice, Inbred C57BL. Mutagenicity Tests. Rats. Rats, Inbred F344. Sarcoma / chemically induced. Sarcoma / pathology. Toxicity Tests, Chronic

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  • (PMID = 16741556.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
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64. Sato Y, Mukai M, Sasaki M, Kitao A, Yoneda N, Kobayashi D, Imamura Y, Nakanuma Y: Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease. Pathol Int; 2009 Mar;59(3):201-4
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  • [Title] Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease.
  • A case of intraductal papillary-mucinous neoplasm (IPMN) of the pancreas associated with polycystic liver and kidney disease is reported.
  • Pancreatoduodenectomy was performed, and a pathological diagnosis of intraductal papillary-mucinous adenoma of branch duct type of the pancreas was made.
  • He died of renal failure and hepatic failure due to recurrent cholangitis 12 years after the operation.
  • The kidneys showed that the cysts originated from all segments of the renal tubule.
  • The autopsy findings suggested that the patient had suffered from autosomal-dominant polycystic kidney disease (ADPKD), but he did not have a family history of ADPKD.
  • This case demonstrates that IPMN of the pancreas can occur as an extrarenal complication in patients with polycystic liver and kidney disease.
  • [MeSH-major] Adenoma / complications. Liver Diseases / complications. Pancreatic Neoplasms / complications. Polycystic Kidney, Autosomal Dominant / complications


65. Adley BP, Gupta A, Lin F, Luan C, Teh BT, Yang XJ: Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol; 2006 Jul;126(1):79-85
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  • [Title] Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma.
  • Kidney-specific cadherin (Ksp-cad) recently was proposed to differentiate chromophobe renal cell carcinoma (RCC) from oncocytoma based on a finding of Ksp-cad expression in 97% of chromophobe RCCs but only 3% of oncocytomas.
  • We attempted to evaluate Ksp-cad expression in renal tumors using expression microarrays and immunohistochemical analysis.
  • Ksp-cad messenger RNA (mRNA) levels were examined in 158 renal tumors, including 15 chromophobe RCCs and 15 oncocytomas.
  • Immunohistochemical analysis was performed on tissue microarrays containing 125 renal tumors, including 36 chromophobe RCCs and 41 oncocytomas.
  • Ksp-cad mRNA compared with normal kidney tissue was 89% in chromophobe RCC and 64% in oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Cadherins / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Oligonucleotide Array Sequence Analysis. RNA, Messenger / metabolism. Retrospective Studies


66. Veroux M, Giuffrida G, Gagliano M, Giaquinta A, Tallarita T, Sorbello M, Corona D, Zerbo D, Vizcarra D, Scriffignano V, Cannizzaro MA, Veroux P: Evaluation of thyroid disease in kidney transplantation candidates: management and follow-up. Transplant Proc; 2009 May;41(4):1142-4
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  • [Title] Evaluation of thyroid disease in kidney transplantation candidates: management and follow-up.
  • INTRODUCTION: Diagnosis of thyroid disease is fundamental in the evaluation of patients awaiting kidney transplantation.
  • We analyzed the incidence of thyroid disease in patients with end-stage renal disease (ESRD) and evaluated its evolution before and after kidney transplantation.
  • PATIENTS AND METHODS: Between January 2000 and May 2008, we evaluated 323 candidates for kidney transplantation.
  • Patients with thyroid cancer were considered eligible for kidney transplantation after at least 2 years since treatment.
  • RESULTS: One-hundred-four patients with ESRD (44%) had functional or morphologic changes in the thyroid gland.
  • Forty-one patients (17.4%) underwent fine-needle aspiration cytology; 3 demonstrated showed papillary carcinoma; 3, follicular adenomas; 8, uncertain cytologic lesions; and 27, a nodular goiter.
  • Of the 184 transplant recipients, 10 underwent surgery to treat thyroid disease: 8 with multinodular goiter, 1 with micropapillary carcinoma, and 1 with follicular adenoma.
  • Early diagnosis and treatment significantly decreased morbidity and mortality in patients awaiting transplantation.
  • [MeSH-major] Carcinoma, Papillary / complications. Kidney Failure, Chronic / surgery. Kidney Transplantation. Neoplasm Recurrence, Local / complications. Thyroid Neoplasms / epidemiology


67. Kummerfeld M, Knieriem A, Wohlsein P: [Osteomyelitis and papillary renal adenoma in a red panda (Ailurus fulgens fulgens)]. Dtsch Tierarztl Wochenschr; 2008 Nov;115(11):421-5
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  • [Title] [Osteomyelitis and papillary renal adenoma in a red panda (Ailurus fulgens fulgens)].
  • [Transliterated title] Osteomyelitis und papilläres renales Adenom bei einem Kleinen Pandabären (Ailurus fulgens fulgens).
  • Additionally, in the kidney a papillary renal adenoma was found.
  • Immunohistochemistry revealed an expression of cytokeratins 8 and/or 19 indicating an origin from the renal tubular epithelium.
  • [MeSH-major] Carcinoma, Renal Cell / veterinary. Kidney Neoplasms / veterinary. Osteomyelitis / veterinary. Ursidae

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  • (PMID = 19024549.001).
  • [ISSN] 0341-6593
  • [Journal-full-title] DTW. Deutsche tierärztliche Wochenschrift
  • [ISO-abbreviation] DTW. Dtsch. Tierarztl. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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68. Shen SS, Krishna B, Chirala R, Amato RJ, Truong LD: Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol; 2005 Jul;18(7):933-40
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  • [Title] Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms.
  • Renal cell neoplasms are presumably derived from different cell types of the nephron.
  • Clear cell and papillary renal cell carcinoma (RCC) are thought to be of proximal tubular origin, whereas oncocytoma and chromophobe RCC are derived from intercalated cells of distal nephron.
  • A few molecules, such as RCC marker and CD10, have been shown to be markers for clear cell RCC and papillary RCC.
  • Such markers are not yet available for renal tumors presumably of the distal nephron.
  • The expression of kidney-specific (Ksp) cadherin, a recently cloned gene thought to be transcribed exclusively in the kidney, was studied in normal human kidney, as well as in 105 primary renal neoplasms, including 42 clear cell RCC, 30 papillary RCC, 13 chromophobe RCC, and 20 oncocytomas.
  • The Ksp-cadherin expression was noted preferentially in distal convoluted tubules with a basolateral membrane stain in normal kidney.
  • All 13 chromophobe RCC and 19 of 20 oncocytomas showed diffuse and strong immunoreactivity for Ksp-cadherin, while only 14% clear cell RCC and 13% papillary RCC showed focal positivity.
  • The RCC marker expression was detected in 85%, 98%, 15% and 0% of clear cell RCC, papillary RCC, chromophobe RCC, and oncocytoma, respectively.
  • A few clear cell RCC and papillary RCC showed dual expression of both RCC marker and Ksp-cadherin, which appear to have distinct histologic features.
  • These results demonstrated high sensitivity and specificity of Ksp-cadherin for distal convoluted tubules, which can be used as adjunct for diagnosis of chromophobe RCC.
  • [MeSH-major] Cadherins / analysis. Kidney / chemistry. Kidney Neoplasms / pathology. Nephrons / chemistry
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Biomarkers / analysis. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Kidney Tubules / chemistry

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  • (PMID = 15696118.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cadherins; 0 / FAT1 protein, human
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69. Mazal PR, Exner M, Haitel A, Krieger S, Thomson RB, Aronson PS, Susani M: Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol; 2005 Jan;36(1):22-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma.
  • Distinguishing renal oncocytoma from chromophobe and other renal carcinomas is essential, considering their differing biological potentials.
  • Although renal oncocytoma is considered a benign tumor, chromophobe renal cell carcinoma has potentially malignant biological behavior.
  • We report a novel immunohistochemical approach based on the expression of a recently described kidney-specific cadherin (Ksp-cadherin) for the differential diagnosis of these 2 tumors.
  • We compared Ksp-cadherin expression in 212 renal tumors, including 102 clear cell renal carcinomas, 46 papillary renal cell carcinomas, 30 chromophobe carcinomas, 3 collecting duct carcinomas, and 31 oncocytomas.
  • We found that chromophobe renal cell carcinomas consistently (96.7% of cases) demonstrated a distinctive membrane pattern of Ksp-cadherin expression, whereas renal oncocytomas (3.2%), clear cell renal cell carcinomas (0%), papillary renal cell carcinomas (2.2%), and collecting duct carcinomas (0%) usually did not express Ksp-cadherin.
  • Whereas CK7 was detected in different types of renal cell carcinomas, Ksp-cadherin was expressed almost exclusively in chromophobe renal cell carcinomas.
  • Immunohistochemical analysis of Ksp-cadherin offers a fast, reliable approach for the distinguishing between renal oncocytoma and chromophobe renal cell carcinoma that is applicable for routine pathology laboratory studies without the need for time-consuming and costly ancillary studies.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Papillary / metabolism. Adenoma, Oxyphilic / metabolism. Biomarkers, Tumor / analysis. Cadherins / biosynthesis. Kidney Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Blotting, Western. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Middle Aged


70. Westermann DH, Rüdiger T, Lohe B, Frohneberg D: [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient]. Urologe A; 2010 Dec;49(12):1527-31
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  • [Title] [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient].
  • We report on a rare case of bilateral oncocytic kidney tumors in a patient with Birt-Hogg-Dubé syndrome (BHD).
  • BHD is an autosomal inherited cancer syndrome associated with multiple kidney tumors, benign cutaneous tumors, and pulmonary cysts with spontaneous pneumothorax.
  • [MeSH-major] Birt-Hogg-Dube Syndrome / diagnosis. Birt-Hogg-Dube Syndrome / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / surgery. Male. Middle Aged. Syndrome. Treatment Outcome

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  • (PMID = 20949256.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Oncocytoma, renal
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71. Nigro M, Piscioli I, Franceschetti I, Barberini F, Lupattelli L, Scialpi M: Simultaneous occurrence of renal oncocytoma and B small cell lymphoma in the same kidney: report of two cases. Urol Int; 2009;83(2):242-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous occurrence of renal oncocytoma and B small cell lymphoma in the same kidney: report of two cases.
  • Two cases of simultaneous occurrence of oncocytoma (OC) associated with small B-cell lymphoma in the same kidney were investigated.
  • Computed tomography, performed for staging purposes, incidentally revealed a small hypo- and hyperattenuating renal mass.
  • Diagnosis of OC was performed on the specimen by morphology, immunohistochemistry and electron microscopy.
  • The occurrence of OC and non-Hodgkin lymphoma in the same kidney has never been reported.
  • However, when some solid, small hyper- or hypoattenuating masses occur in the kidney, the diagnosis by computed tomography alone is always a challenge and other malignant neoplasms may be considered.
  • Immunohistochemistry and electron microscopy allow a definitive diagnosis of OC.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms. Lymphoma, B-Cell. Neoplasms, Multiple Primary

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19752626.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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72. DeWitt J, Gress FG, Levy MJ, Hernandez LV, Eloubeidi MA, Mishra G, Sherman S, Al-Haddad MA, LeBlanc JK: EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience. Gastrointest Endosc; 2009 Sep;70(3):573-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience.
  • BACKGROUND: Tissue sampling of renal lesions is traditionally performed with percutaneous US or CT guidance.
  • To date, only 3 known cases of EUS-guided FNA (EUS-FNA) of a renal mass have been reported.
  • OBJECTIVE: To describe a multicenter experience with the indications, yield, and complications from attempted EUS-FNA of a kidney mass.
  • PATIENTS: Consecutive subjects undergoing attempted EUS-FNA of a kidney mass.
  • Endosonographers at 15 other teaching hospitals were contacted regarding EUS findings and follow-up of any EUS-guided renal biopsies previously attempted or considered at that institution.
  • INTERVENTIONS: EUS-FNA of a kidney mass.
  • MAIN OUTCOME MEASUREMENTS: Biopsy indications, yield, diagnosis, and complications.
  • Kidney masses (median diameter 32 mm; range 11-60 mm) were located in the upper (n = 12) and lower (n = 3) poles of the left (n = 10) and right (n = 5) kidneys, respectively.
  • Results of EUS-FNA (median 3 passes; range 2-4 passes) in 13 (87%) procedures were diagnostic of (n = 7) or highly suspicious for (n = 1) renal cell carcinoma (RCC), atypical cells (n = 2), oncocytoma (n = 1), benign cyst (n = 1), and nondiagnostic (n = 1).
  • CONCLUSIONS: EUS-FNA of renal masses is rarely performed at the U.S. teaching hospitals surveyed.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Endosonography / methods. Kidney Neoplasms / pathology. Kidney Neoplasms / ultrasonography
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / ultrasonography. Aged. Aged, 80 and over. Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / ultrasonography. Cohort Studies. Confidence Intervals. Female. Follow-Up Studies. Hospitals, Teaching. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Probability. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. United States

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  • (PMID = 19560139.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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73. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CAS No. 123-35-3) in F344/N rats and B6C3F1 mice (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Dec;(557):1-163
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  • Right kidney and liver weights of dosed males and females were generally significantly greater than those of the vehicle controls.
  • In special study rats evaluated on day 23, the incidences and severities of chronic progressive nephropathy (CPN) and renal tubule degeneration were increased in 2 g/kg males.
  • At the end of the 3-month study, the incidences of renal tubule necrosis were significantly increased in all dosed groups of males and females.
  • The right kidney weights of 1 g/kg females and the liver weights of females administered 0.5 or 1 g/kg were significantly increased.
  • All 1 g/kg male rats died before the end of the study due to renal toxicity.
  • In the standard evaluation of the kidney, the incidence of renal tubule adenoma was significantly increased in 0.5 g/kg male rats, and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in 0.25 and 0.5 g/kg males.
  • In both the extended evaluation and the combined standard and extended evaluations, the incidences of renal tubule adenoma and the combined incidences of renal tubule adenoma or carcinoma were significantly increased in the 0.25 and 0.5 g/kg groups of males.
  • The incidences of renal tubule nephrosis (nephrosis) were markedly increased in all dosed groups of both sexes except in 0.25 g/kg females.
  • The incidences of hyperplasia of the transitional epithelium lining the pelvis and overlying the renal papilla were significantly increased in all dosed groups of males and females.
  • Liver neoplasms included hepatocellular adenoma and hepatocellular carcinoma in males and females and hepatoblastoma in males.
  • The incidences of hepatocellular hypertrophy were significantly increased in 0.5 g/kg males and females, as was the incidence of mixed cell focus in 0.5 g/kg females.
  • CONCLUSIONS: Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of beta-myrcene in male F344/N rats based on increased incidences of renal tubule neoplasms.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female F344/N rats based on increased incidences of renal tubule adenoma.
  • There was clear evidence of carcinogenic activity of beta-myrcene in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma.
  • There was equivocal evidence of carcinogenic activity of beta-myrcene in female B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma and carcinoma.
  • Administration of beta-myrcene induced nonneoplastic lesions in the kidney of male and female rats, nose of male rats, and liver of male and female mice.
  • [MeSH-major] Adenoma / chemically induced. Carcinoma, Hepatocellular / chemically induced. Hepatoblastoma / chemically induced. Kidney Neoplasms / chemically induced. Liver Neoplasms / chemically induced. Monoterpenes / toxicity. Neoplasms, Experimental / chemically induced
  • [MeSH-minor] Animals. Carcinogenicity Tests. Female. Humans. Kidney / drug effects. Kidney / pathology. Longevity / drug effects. Male. Mice. Mice, Inbred Strains. Mutagenicity Tests. Nose / drug effects. Nose / pathology. Rats. Rats, Inbred F344. Toxicity Tests, Chronic

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  • (PMID = 21415873.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Monoterpenes; 123-35-3 / beta-myrcene
  • [Investigator] Chan PC; Cesta MF; Sills RC; Bishop JB; Bristol DW; Bucher JR; Chhabra RS; Foster PM; Herbert RA; Hooth MJ; King-Herbert AP; Kissling GE; Malarkey DE; Roycroft JH; Sanders JM; Smith CS; Travlos GS; Walker NJ; Witt KL
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74. Skinnider BF, Amin MB: An immunohistochemical approach to the differential diagnosis of renal tumors. Semin Diagn Pathol; 2005 Feb;22(1):51-68
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  • [Title] An immunohistochemical approach to the differential diagnosis of renal tumors.
  • Renal neoplasms comprise several distinct clinicopathologic entities with potential prognostic and the rapeutic differences.
  • Although careful morphologic examination using sections stained with hematoxylin and eosin will allow for the correct diagnosis in the majority of cases, there is sufficient overlap between several entities such that ancillary techniques may be necessary to arrive at the correct diagnosis.
  • In routine diagnostic surgical pathology practice of renal tumors, immunohistochemistry is the foremost ancillary technique.
  • Using an approach based on common histologic patterns (tumors with clear cytoplasm, granular cytoplasm, tubulopapillary architecture, spindle cell morphology, small round-cell morphology, and infiltrating poorly differentiated carcinoma), we will discuss the utility of immunohistochemistry in the differential diagnosis of renal neoplasms.
  • In recent years, needle biopsies from renal masses are being increasingly performed.
  • In these small biopsies, the entire range of cytoarchitectural features that are generally necessary to make a diagnosis may not be fully appreciated.
  • Immunohistochemistry may be helpful in this setting to narrow the differential diagnosis or to arrive at a definitive diagnosis.
  • Finally, the use of immunohistochemistry for the confirmation of metastatic renal cell carcinoma presenting at distant sites will be discussed.
  • Panels of immunohistochemical stains are proposed for different settings, including renal cell carcinoma (RCC) marker, CD10, and vimentin to suggest renal origin of a metastatic tumor, and markers to aid in subclassification of RCC, including parvalbumin and c-kit for chromophobe RCC, and cytokeratin 7 and alpha-methyl-acyl-CoA racemase for papillary RCC.
  • [MeSH-major] Carcinoma / diagnosis. Immunohistochemistry. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Humans. Neoplasm Metastasis. Translocation, Genetic

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  • (PMID = 16512599.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 82
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75. Hashimoto T, Togo Y, Yasuda K, Fukui K, Nagkai J, Nakao A, Higuchi Y, Maruyama T, Yamamoto S, Kondo N, Nojima M, Takiuchi H, Mori Y, Hirota S, Shimai H: [Oncocytoma associated with acquired cystic disease of kidney (ACDK): a case report]. Hinyokika Kiyo; 2005 Nov;51(11):747-9
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  • [Title] [Oncocytoma associated with acquired cystic disease of kidney (ACDK): a case report].
  • A case of renal oncocytoma associated with acquired cystic disease of kidney (ACDK) in a 56-year-old man is reported.
  • He had received hemodialysis for 15 years because of chronic renal failure.
  • Computed tomography (CT) was performed because of distention in the upper abdomen, revealing a right renal tumor.
  • He underwent laparoscopic right nephrectomy, and was diagnosed with renal oncocytoma.
  • There have been reported 8 cases of renal oncocytoma in hemodialysis patients, and our case was the third one associated with ACDK in the literature.
  • [MeSH-major] Adenoma, Oxyphilic / complications. Kidney Diseases, Cystic / complications. Kidney Neoplasms / complications
  • [MeSH-minor] Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16363707.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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76. Matsuda K, Kousaka Y, Nagamine N, Tsunoda N, Taniyama H: Papillary renal adenoma of distal nephron differentiation in a horse. J Vet Med Sci; 2007 Jul;69(7):763-5
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  • [Title] Papillary renal adenoma of distal nephron differentiation in a horse.
  • A 20-year-old thoroughbred mare had a mass in the right kidney.
  • From these results, this case was diagnosed as papillary renal adenoma of distal nephron differentiation.

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  • (PMID = 17675811.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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77. Cheng L, Zhang S, MacLennan GT, Lopez-Beltran A, Montironi R: Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms. Hum Pathol; 2009 Jan;40(1):10-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms.
  • Renal cell carcinomas comprise a heterogeneous group of epithelial neoplasms with diverse biologic potential and variable clinical outcomes.
  • The application of molecular and cytogenetic techniques to the study of renal neoplasms has improved our understanding of the molecular mechanisms responsible for tumor initiation and progression.
  • Molecular classification of renal cell carcinomas has also provided new avenues for diagnosis, clinical outcome, and therapy response prediction.
  • In this article, we review the molecular markers for various renal epithelial neoplasms and discuss the mechanisms underlying the development of these neoplasms.
  • We also evaluate the use of molecular and cytogenetic techniques in establishing an accurate diagnosis in difficult cases and their potential usefulness in accurately classifying renal neoplasms, assessing prognosis, and selecting appropriate therapy.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Gene Expression Profiling. Kidney Neoplasms / genetics. Molecular Biology. Neoplasms, Glandular and Epithelial / genetics
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / genetics. Adenocarcinoma, Clear Cell / pathology. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Diagnosis, Differential. Humans. Prognosis

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  • (PMID = 19027455.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 182
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78. National Toxicology Program: Toxicology and carcinogenesis studies of alpha-methylstyrene (Cas No. 98-83-9) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2007 Nov;(543):1-210
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  • Kidney weights were significantly increased in 1,000 ppm males and 600 and 1,000 ppm females.
  • The incidences of renal hyaline droplet accumulation were similar between exposed groups and chamber control groups, but the severity of hyaline droplet accumulation in 600 and 1,000 ppm males was greater than in chamber controls.
  • Morphologic changes were not detected in the liver.
  • Two 1,000 ppm males and one 300 ppm male had renal tubule carcinomas, and one 300 ppm male had a renal tubule adenoma.
  • Because of the neoplasms observed in 300 and 1,000 ppm males at the end of the 2-year study and the finding of alpha2μ-globulin accumulation in the kidneys at 3 months, which is often associated with kidney neoplasms, additional step sections of kidney were prepared; additional males with focal hyperplasia or adenoma were identified.
  • The incidences of renal tubule adenoma and carcinoma (combined) in the 1,000 ppm males were significantly greater than those in the chamber controls when the single and step sections were combined.
  • The incidence of mineralization of the renal papilla was significantly increased in 1,000 ppm males.
  • The incidence of mononuclear cell leukemia in 1,000 ppm males was significantly increased compared to the chamber controls.
  • In the nose, the incidences of basal cell hyperplasia were significantly increased in all exposed groups of males and females, and the incidences of degeneration of the olfactory epithelium were increased in 1,000 ppm males and females and 300 ppm females.
  • The incidences of hepatocellular adenoma or carcinoma (combined) were significantly increased in the 100 and 600 ppm males and in all exposed groups of females.
  • The incidences of hepatocellular adenoma were significantly increased in all exposed groups of females, and the incidences in all exposed groups of males and females exceeded the historical range for chamber controls.
  • CONCLUSIONS: Under the conditions of this 2-year inhalation study, there was some evidence of carcinogenic activity of alpha-methylstyrene in male F344/N rats based on increased incidences of renal tubule adenomas and carcinomas (combined).
  • The increased incidence of mononuclear cell leukemia in 1,000 ppm male F344/N rats may have been related to alpha-methylstyrene exposure.
  • There was equivocal evidence of carcinogenic activity of alpha-methylstyrene in male B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma or carcinoma (combined).
  • There was clear evidence of carcinogenic activity of alpha-methylstyrene in female B6C3F1 mice based on increased incidences of hepatocellular adenomas and carcinomas.
  • Exposure of rats to alpha-methylstyrene resulted in kidney toxicity, which in males exhibited some features of alpha2μ-globulin nephropathy.
  • Exposure to alpha-methylstyrene resulted in nonneoplastic lesions of the nose in male and female rats and mice and of the liver and kidney in female mice.
  • [MeSH-minor] Animals. Body Weight / drug effects. CHO Cells. Cricetinae. Cricetulus. DNA Damage. Female. Inhalation Exposure. Kidney / drug effects. Kidney / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia, Myeloid / chemically induced. Leukemia, Myeloid / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Micronuclei, Chromosome-Defective / chemically induced. Nose Diseases / chemically induced. Rats. Rats, Inbred F344

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  • (PMID = 18685715.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; 0 / Carcinogens; 0 / Mutagens; 0 / Styrenes; 98-83-9 / alpha-methylstyrol
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79. Gassler N, Haferkamp A, Flechtenmacher C, Hohenfellner M, Schirmacher P, Autschbach F: [Renal oncocytoma with metastasis from breast carcinoma: a contribution to the differential diagnosis of tumourous lesions of the kidney]. Pathologe; 2006 May;27(3):217-21
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  • [Title] [Renal oncocytoma with metastasis from breast carcinoma: a contribution to the differential diagnosis of tumourous lesions of the kidney].
  • The case of a renal oncocytoma involvement by metastasis from breast carcinoma in a 83-year-old woman is reported.
  • In conclusion, metastasis of breast carcinoma to a benign renal tumour is very rare.
  • [MeSH-major] Adenoma, Oxyphilic / secondary. Breast Neoplasms / pathology. Kidney Neoplasms / secondary. Neoplasm Metastasis
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • [Cites] Int J Surg Pathol. 2003 Apr;11(2):127-35 [12754635.001]
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  • (PMID = 16642392.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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80. Rossi GP, Pessina AC, Heagerty AM: Primary aldosteronism: an update on screening, diagnosis and treatment. J Hypertens; 2008 Apr;26(4):613-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary aldosteronism: an update on screening, diagnosis and treatment.
  • BACKGROUND: Primary aldosteronism is much more common than previously held; it implies an excessive organ damage to the heart, vessels and kidney, which translates into an excess of cardiovascular events.
  • These two features, along with the fact that the arterial hypertension and the hypokalemia can be corrected with a timely diagnosis and an appropriate therapy, warrant an aggressive diagnostic approach in hypertensive patients.
  • At variance, the identification of primary aldosteronism subtypes, for example, the differentiation of patients with an aldosterone-producing adenoma from those with idiopathic hyperaldosteronism should be undertaken at tertiary referral centres.
  • Thus, an aggressive diagnostic approach is mandatory at least in some subgroups of hypertensive patients who are at higher prior risk of primary aldosteronism or can benefit more from an accurate diagnosis.
  • [MeSH-major] Hyperaldosteronism / diagnosis. Hyperaldosteronism / therapy. Hypertension / diagnosis. Hypertension / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Mass Screening. Prevalence

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  • [CommentIn] J Hypertens. 2008 Aug;26(8):1708-9; author reply 1709-11 [18622252.001]
  • (PMID = 18327065.001).
  • [ISSN] 0263-6352
  • [Journal-full-title] Journal of hypertension
  • [ISO-abbreviation] J. Hypertens.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 127
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81. National Toxicology Program: NTP toxicology and carcinogenesis studies of decalin (CAS No. 91-17-8) in F344/N rats and B6C3F(1) mice and a toxicology study of decalin in male NBR rats (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2005 Jan;(513):1-316
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  • Male NBR rats do not produce alpha2u-globulin; the NBR rats were included to study the relationship of alpha2u-globulin and renal lesion induction.
  • Renal toxicity studies were performed in male F344/N and NBR rats.
  • The numbers of labeled cells and the labeling indices in the left kidney of 200 and 400 ppm F344/N male rats were significantly greater than those in the chamber controls.
  • Kidney weights of male F344/N rats exposed to 50 ppm or greater were significantly increased.
  • Exposure-related hyaline droplet accumulation, degeneration and regeneration of renal cortical tubules, and granular casts occurred in the kidney of exposed F344/N male rats.
  • 3-MONTH STUDY IN RATS: Groups of 25 male and 20 female F344/N rats were exposed to 0, 25, 50, 100, 200, or 400 ppm decalin vapor 6 hours per day, 5 days per week for 2 (five male renal toxicity rats), 6 (10 male and 10 female clinical pathology rats), or 14 (10 core study rats) weeks.
  • Urinalysis results indicated that decalin exposure caused increases in urine glucose and protein concentrations and enzyme activities that were consistent with the renal lesions observed microscopically.
  • Renal toxicity studies were performed on rats sacrificed at 2 and 6 weeks and at the end of the study.
  • In kidney tissue examined for cell proliferation, the numbers of PCNA-labeled cells and labeling indices were generally significantly greater than those of the chamber controls in exposed groups of rats at all three time points.
  • Concentrations of alpha2u-globulin in the kidney as well as the alpha2u-globulin/soluble protein ratios were significantly increased at week 2 in all exposed groups and in the 200 and 400 ppm groups at week 6 and at the end of the study.
  • Absolute and/or relative kidney and liver weights of male rats exposed to 50 ppm or greater were increased.
  • Incidences of renal tubule regeneration and granular casts in the medulla of the kidney in exposed male rats were increased, and the severities of hyaline droplets generally increased with increasing exposure concentration.
  • Incidences of renal tubule adenoma and adenoma or carcinoma (combined) and of benign or malignant pheochromocytoma (combined) of the adrenal medulla in 100 and 400 ppm males were significantly increased.
  • Nonneoplastic lesions related to decalin exposure occurred in the kidney of male rats.
  • CONCLUSIONS: Under the conditions of these studies, there was clear evidence of carcinogenic activity of decalin in male F344/N rats based on increased incidences of renal tubule neoplasms.
  • The increased incidences of benign or malignant pheochromocytoma (combined) of the adrenal medulla in male rats were also considered to be exposure related.
  • Exposure of male rats to decalin resulted in nonneoplastic lesions of the kidney characteristic of alpha2u-globulin accumulation.
  • [MeSH-minor] Administration, Inhalation. Animal Feed / analysis. Animals. Atmosphere Exposure Chambers. Body Weight / drug effects. Female. Genitalia, Male / pathology. Kidney Diseases / chemically induced. Kidney Diseases / pathology. Male. Mice. Mice, Inbred Strains. Mutagens / toxicity. Organ Size / drug effects. Rats. Rats, Inbred F344. Reproduction / drug effects

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  • (PMID = 15891779.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mutagens; 0 / Naphthalenes; 88451Q4XYF / decalin
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82. Nobili C, Franciosi C, Degrate L, Caprotti R, Romano F, Perego E, Trezzi R, Leone BE, Uggeri F: A case of pancreatic heterotopy of duodenal wall, intraductal papillary mucinous tumor and intraepithelial neoplasm of pancreas, papillary carcinoma of kidney in a single patient. Tumori; 2006 Sep-Oct;92(5):455-8
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  • [Title] A case of pancreatic heterotopy of duodenal wall, intraductal papillary mucinous tumor and intraepithelial neoplasm of pancreas, papillary carcinoma of kidney in a single patient.
  • We report a case of the contemporaneous presence of two histologically different pancreatic neoplasms, one renal cancer and one embryogenic duodenal anomaly in a single patient.
  • A 66-year-old man underwent ultrasound examination because of urinary disorders; a solid neoformation within the inferior pole of the left kidney was observed.
  • Computed tomography confirmed the renal lesion, but also a heterogeneous mass within the pancreatic head appeared without bile ducts dilatation.
  • A second CT scan confirmed the renal and biliary findings, but it revealed a modest enlargement of the pancreatic asymptomatic mass.
  • A resection of the left kidney inferior pole and a pylorus-preserving pancreaticoduodenectomy were performed.
  • Histopathologic analysis of the surgical specimen revealed mild differentiated papillary renal carcinoma, intraductal papillary mucinous adenoma of the pancreatic head, foci of intraepithelial pancreatic neoplasm and pancreatic heterotopy of duodenal muscular and submucosal layers.
  • [MeSH-major] Carcinoma, Pancreatic Ductal. Carcinoma, Papillary. Choristoma. Cystadenocarcinoma, Mucinous. Duodenal Diseases. Kidney Neoplasms. Neoplasms, Multiple Primary. Pancreas. Pancreatic Neoplasms
  • [MeSH-minor] Aged. Carcinoma, Renal Cell / diagnosis. Humans. Magnetic Resonance Imaging. Male. Nephrectomy / methods. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 17168444.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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83. Teodorovich OV, Ternovoĭ SK, Vlasova IS, Zabrodina NB, Fominykh EV, Kesov IaE: [Comparative analysis of modern combined methods in diagnosis of renal cell carcinoma]. Urologiia; 2006 Sep-Oct;(5):3-6, 11
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  • [Title] [Comparative analysis of modern combined methods in diagnosis of renal cell carcinoma].
  • To ascertain the role of multispiral computed tomography (MSCT) in diagnosis of renal cell carcinoma (RCC) and to propose optimal diagnostic policy in RCC patients, we examined 63 patients with suspected renal tumor: 37 (59%) males and 26 (41%) females, age 47-77 ages, mean age 54.2+/-1.5 years, duration of the disease from 1 month to 7 years.
  • By the results of a combined examination and operation on the kidney lesion, the diagnosis of RCC was made in 45 (80.3%) patients including stage I in 21 (46.7%), stage II in 9 (20%), stage III in 13 (28.9%), stage IV in 2 (4.5%) patients.
  • Benign renal tumors were detected in 8 (14.2%) patients, giant cysts of the kidneys--in 5 cases, benign renal tumors--in 3 cases, adenoma--in 2 cases, angiomyolipoma--in 1 case.
  • Detected were also renal malformations in 3 cases, a distant retroperitoneal metastasis of RCC in 1 case, adrenal tumors in 6 (9.5%) cases.
  • [MeSH-major] Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Tomography, Spiral Computed
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Humans. Neoplasm Metastasis. Neoplasm Staging. Nephrectomy

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  • (PMID = 17444144.001).
  • [ISSN] 1728-2985
  • [Journal-full-title] Urologii︠a︡ (Moscow, Russia : 1999)
  • [ISO-abbreviation] Urologiia
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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84. Markkanen-Leppänen M, Mäkitie AA, Passador-Santos F, Leivo I, Hagström J: Bilateral Basal cell adenocarcinoma of the parotid gland: in a recipient of kidney transplant. Clin Med Insights Pathol; 2010 Feb 18;3:1-5

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  • [Title] Bilateral Basal cell adenocarcinoma of the parotid gland: in a recipient of kidney transplant.
  • We report a rare case of bilateral basal cell adenocarcinoma (BcAC) of the parotid gland in a male patient 30 years after kidney transplantation and continuous administration of immunosuppressive therapy.
  • The most important differential diagnosis is basal cell adenoma.

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  • (PMID = 21151548.001).
  • [ISSN] 1179-5557
  • [Journal-full-title] Clinical medicine insights. Pathology
  • [ISO-abbreviation] Clin Med Insights Pathol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2999998
  • [Keywords] NOTNLM ; basal cell adenocarcinoma / immunohistochemistry / post transplantation malignancy / salivary gland cancer
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85. Osunkoya AO, Cohen C, Lawson D, Picken MM, Amin MB, Young AN: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol; 2009 Feb;40(2):206-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
  • In a recent oligonucleotide microarray study, we identified claudin-7 and claudin-8 as candidate markers to distinguish chromophobe renal cell carcinoma from other renal tumors, including oncocytoma.
  • Distinction of these lesions can be difficult by light microscopy but is clinically important because chromophobe renal cell carcinoma has malignant biological potential, whereas renal oncocytoma is benign.
  • Claudin-7 and claudin-8 expression was studied by immunohistochemistry in 11 chromophobe renal cell carcinomas and 17 oncocytomas using formalin-fixed paraffin-embedded tissue sections of tumor with adjacent nonneoplastic kidney.
  • Specificity was verified by negative control reactions without primary antibody and appropriate membranous staining patterns in positive control tissues (colon carcinoma and adjacent nonneoplastic kidney).
  • Claudin-7 protein was expressed in a membranous pattern in 10 of 11 chromophobe renal cell carcinomas and 4 of 17 oncocytomas (P < .01).
  • In chromophobe renal cell carcinoma, 0 of 11 cases showed cytoplasmic, 3 of 11 membranous, and 8 of 11 negative reactions (P < .01).
  • The immunohistochemical pattern of membranous claudin-7 and negative claudin-8 was seen in 7 of 11 chromophobe renal cell carcinomas and 1 of 17 oncocytomas (63% sensitivity, 84% specificity, 88% positive predictive value for chromophobe renal cell carcinoma).
  • Negative claudin-7 and cytoplasmic claudin-8 were observed in 10 of 17 oncocytomas and 0 of 11 chromophobe renal cell carcinomas (59% sensitivity, 100% specificity and positive predictive value for oncocytoma).
  • The distal nephron proteins claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma.
  • Expression of claudin-7 and claudin-8 may reflect the relationship of chromophobe renal cell carcinoma and oncocytoma to intercalated cells of the cortical collecting duct.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Claudins. Diagnosis, Differential. Humans. Immunohistochemistry. Sensitivity and Specificity


86. Hirose A, Okada Y, Fukushima A, Tanaka Y: [A rare case of primary aldosteronism caused by bilateral functioning adrenocortical adenomas with renal cell carcinoma]. J UOEH; 2005 Dec 1;27(4):315-23
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  • [Title] [A rare case of primary aldosteronism caused by bilateral functioning adrenocortical adenomas with renal cell carcinoma].
  • We report a rare case of bilateral primary aldosteronism with renal cell carcinoma.
  • Abdominal CT and MRI revealed tumor masses in both adrenal glands, and a large left renal mass.
  • The preoperative diagnosis was primary aldosteronism due to bilateral functioning adrenocortical adenomas and left renal cell carcinoma.
  • The Pathological diagnosis was left renal cell carcinoma and bilateral functioning adrenocortical adenomas.
  • Primary aldosteronism due to bilateral functioning adrenocortical adenomas is relatively rare and its complication with renal cell carcinoma is an extremely rare case.
  • [MeSH-major] Adrenal Cortex Neoplasms / complications. Adrenocortical Adenoma / complications. Carcinoma, Renal Cell / complications. Hyperaldosteronism / etiology. Kidney Neoplasms / complications


87. Torabinezad S, Kumar PV, Hashemi SB, Rahimi A: Osteoclastomalike giant cell tumor of the parotid gland: report of a case with fine needle aspiration diagnosis. Acta Cytol; 2006 Jan-Feb;50(1):80-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoclastomalike giant cell tumor of the parotid gland: report of a case with fine needle aspiration diagnosis.
  • BACKGROUND: Osteoclastomalike giant cell tumor of the parotid gland has been reported rarely.
  • The tumor has occurred rarely at many sites, such as thyroid, pancreas, soft tissue, breast, skin, heart, colon, lung, kidney, ovary and bladder.
  • CASE: A 35-year-old female presented with a mass in the left parotid gland clinically diagnosed as a pleomorphic adenoma.
  • The smears were diagnosed as positive for malignancy, suggestive of osteoclastomalike giant cell tumor.
  • The tumor was excised, and histopathologic study confirmed the cytologic diagnosis.
  • CONCLUSION: The cytologic findings of osteoclastomalike giant cell tumor of the parotid gland have not been previously reported.
  • FNA aided the diagnosis and planning of treatment.
  • FNA is important in the diagnosis of parotid tumors.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Parotid Gland / pathology. Parotid Neoplasms / diagnosis

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  • (PMID = 16514845.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Geramizadeh B, Ravanshad M, Rahsaz M: Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):167-71
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  • [Title] Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma.
  • Renal oncocytoma, conventional RCC (granular cell type) and chromophobe RCC have different prognosis.
  • In a 5-year study of 128 renal tumors, we selected 76 cases [30 conventional RCC (CRCC), 16 papillary RCC, 21 chromophobe RCC (ChRCC), 8 oncocytoma, 1 collecting duct carcinoma (cdc)] and staining with Hale's colloidal iron, CK7, CK8, CK18, CK19, CK20, Vimentin, EMA, CD10 and RCC marker were done.
  • No significant difference was seen between renal tumor subtypes with CK8, CK18, CK19, CK20 and EMA.
  • Vimentin, CK7, CD10, RCC marker and Hale's colloidal iron can be used for the differential diagnosis of problematic epithelial tumors of kidney (CRCC, ChRCC and oncocytoma) - i.e.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Keratin-7 / metabolism. Male. Middle Aged. Mitogen-Activated Protein Kinases / metabolism. Neprilysin / metabolism. Vimentin / metabolism


89. Liu L, Qian J, Singh H, Meiers I, Zhou X, Bostwick DG: Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. Arch Pathol Lab Med; 2007 Aug;131(8):1290-7
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  • [Title] Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis.
  • CONTEXT: The separation of chromophobe renal cell carcinoma, oncocytoma, and clear cell renal cell carcinoma using light microscopy remains problematic in some cases.
  • OBJECTIVE: To determine a practical immunohistochemical panel for the differential diagnosis of chromophobe carcinoma.
  • DESIGN: Vimentin, glutathione S-transferase alpha (GST-alpha), CD10, CD117, cytokeratin (CK) 7, and epithelial cell adhesion molecule (EpCAM) were investigated in 22 cases of chromophobe carcinoma, 17 cases of oncocytoma, and 45 cases of clear cell carcinoma.
  • RESULTS: Vimentin and GST-alpha expression were exclusively observed in clear cell carcinoma.
  • CD10 staining was more frequently detected in clear cell carcinoma (91%) than in chromophobe carcinoma (45%) and oncocytoma (29%).
  • CD117 was strongly expressed in chromophobe carcinoma (82%) and oncocytoma (100%), whereas none of the cases of clear cell carcinomas were immunoreactive.
  • EpCAM protein was expressed in all 22 cases of chromophobe carcinoma in more than 90% of cells, whereas all EpCAM-positive oncocytomas (5/17; 29%) displayed positivity in single cells or small cell clusters.
  • CONCLUSIONS: Using the combination of 3 markers (vimentin, GST-alpha, and EpCAM), we achieved 100% sensitivity and 100% specificity for the differential diagnosis of chromophobe carcinoma, oncocytoma, and clear cell carcinoma.
  • The pattern of "vimentin(-)/GST-alpha(-)" effectively excluded clear cell carcinoma, and homogeneous EpCAM expression confirmed the diagnosis of chromophobe carcinoma rather than oncocytoma.
  • CD117 and CK7 were also useful markers and could be used as second-line markers for the differential diagnosis, with high specificity (100%) and high sensitivity (90% and 86%, respectively).
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Immunoenzyme Techniques / methods. Kidney Neoplasms / diagnosis. Neoplasm Proteins / analysis
  • [MeSH-minor] Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Humans. Predictive Value of Tests


90. Mete O, Kilicaslan I, Gulluoglu MG, Uysal V: Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis. Virchows Arch; 2005 Dec;447(6):938-46
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  • [Title] Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis.
  • Among the epithelial renal tumours with eosinophilic cytoplasm, the main differential diagnostic problem arises between renal oncocytomas (ROs) and eosinophilic variants of chromophobe renal cell carcinomas (RCCs).
  • We investigated the possible role of anti-mitochondrial (AMA), anti-caveolin 1 (CAV1), anti-CD63 (CD63) and anti-cytokeratin 14 (CK14) antibodies in the differential diagnosis of eosinophilic epithelial tumours and applied the Muller and Mowry modification of Hale's colloidal iron stain (HCI).
  • Thirty-five ROs and 77 eosinophilic RCCs (27 chromophobe, 28 clear cell and 22 papillary RCCs) were included in this study.
  • We showed CK14 antibody not to be useful in the differential diagnosis of the eosinophilic epithelial renal tumours.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Biomarkers, Tumor / analysis. Kidney Neoplasms / metabolism. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, CD / metabolism. Antigens, CD63. Carcinoma, Renal Cell / metabolism. Carcinoma, Renal Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / metabolism. Male. Middle Aged. Mitochondria / immunology. Platelet Membrane Glycoproteins / metabolism. Sensitivity and Specificity

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  • (PMID = 16133362.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD63; 0 / Biomarkers, Tumor; 0 / CD63 protein, human; 0 / Platelet Membrane Glycoproteins; 68238-35-7 / Keratins
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91. National Toxicology Program: Toxicology and carcinogenesis studies of divinylbenzene-HP (Cas No. 1321-74-0) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2006 Nov;(534):1-290
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  • Relative kidney weights of 50 ppm or greater males and relative liver weights of 200 and 400 ppm males were significantly greater than those of the chamber controls.
  • Kidney and liver weights of exposed groups of females were significantly greater than those of the chamber controls.
  • Renal tubule necrosis and regeneration occurred at 200 ppm.
  • Kidney and liver weights of exposed groups of males and of 400 ppm females were generally greater than those of the chamber controls.
  • Incidences of degeneration of the olfactory epithelium in 200 and 400 ppm rats and basal cell hyperplasia of the olfactory epithelium in rats exposed to 100 ppm or greater were significantly increased.
  • Exposure to divinylbenzene was associated with necrosis of the liver and kidney in 200 ppm males and females dying early.
  • Renal tubule carcinomas occurred in two of 50 males exposed to 400 ppm in the original kidney sections, an incidence that exceeded the historical control range.
  • In 400 ppm males, the incidence of renal tubule hyperplasia was increased, and the incidence of nephropathy was significantly increased.
  • Following combined analysis of single and step-section data, the incidences of renal tubule adenoma and adenoma or carcinoma (combined) were marginally higher in 200 and 400 ppm males, and the incidence of renal tubule hyperplasia was significantly increased in 400 ppm males.
  • The incidences of malignant glial cell tumors (malignant astrocytoma and oligodendroglioma) in the brain were slightly increased in 100 and 200 ppm males, and the incidence in the 200 ppm group exceeded the historical range for chamber controls.
  • The incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) in 100 ppm males were greater than chamber control incidences, but the incidences of adenoma or carcinoma (combined) were within the historical control range.
  • The incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) in all exposed groups of females were generally greater than those of the chamber controls; the incidences were at the upper end or exceeded the historical control ranges.
  • CONCLUSIONS: Under the conditions of this 2-year inhalation study, there was equivocal evidence of carcinogenic activity of divinylbenzene-HP in male F344/N rats based upon the occurrence of carcinomas in the kidney and glial tumors in the brain.
  • There was equivocal evidence of carcinogenic activity of divinylbenzene-HP in female B6C3F1 mice based on the incidences of alveolar/bronchiolar adenoma or carcinoma (combined) in the lung.
  • [MeSH-minor] Animals. Dose-Response Relationship, Drug. Female. Inhalation Exposure. Kidney / drug effects. Kidney / pathology. Liver / drug effects. Liver / pathology. Male. Mice. Mice, Inbred Strains. Organ Size / drug effects. Rats. Rats, Inbred F344

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  • (PMID = 17342197.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vinyl Compounds; IZ715T4SBU / divinyl benzene
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92. Yukinawa N, Oba S, Kato K, Taniguchi K, Iwao-Koizumi K, Tamaki Y, Noguchi S, Ishii S: A multi-class predictor based on a probabilistic model: application to gene expression profiling-based diagnosis of thyroid tumors. BMC Genomics; 2006;7:190
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A multi-class predictor based on a probabilistic model: application to gene expression profiling-based diagnosis of thyroid tumors.
  • BACKGROUND: Although microscopic diagnosis has been playing the decisive role in cancer diagnostics, there have been cases in which it does not satisfy the clinical need.
  • Differential diagnosis of malignant and benign thyroid tissues is one such case, and supplementary diagnosis such as that by gene expression profile is expected.
  • RESULTS: With four thyroid tissue types, i.e., papillary carcinoma, follicular carcinoma, follicular adenoma, and normal thyroid, we performed gene expression profiling with adaptor-tagged competitive PCR, a high-throughput RT-PCR technique.
  • For differential diagnosis, we applied a novel multi-class predictor, introducing probabilistic outputs.
  • CONCLUSION: Molecular diagnosis of thyroid tissues is feasible by gene expression profiling, and the current level is promising towards the automatic diagnostic tool to complement the present medical procedures.
  • [MeSH-major] Bayes Theorem. Gene Expression Profiling. Models, Statistical. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Algorithms. Breast Neoplasms / genetics. Databases, Genetic. Esophageal Neoplasms / genetics. Female. Humans. Kidney Neoplasms / genetics. Leukemia / genetics. Male. Mesothelioma / genetics. Prostatic Neoplasms / genetics. Thyroid Gland / anatomy & histology

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  • (PMID = 16872506.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1550728
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93. Pimenta E, Calhoun DA: Primary aldosteronism: diagnosis and treatment. J Clin Hypertens (Greenwich); 2006 Dec;8(12):887-93
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  • [Title] Primary aldosteronism: diagnosis and treatment.
  • Patients with PA are at an increased risk of developing left ventricular hypertrophy, chronic kidney disease, and endothelial dysfunction.
  • The majority of patients with PA do not have a discernable aldosterone-producing adenoma (APA), and the aldosterone excess is considered idiopathic in etiology and/or attributed to adrenal hyperplasia.
  • [MeSH-major] Hyperaldosteronism / diagnosis. Hyperaldosteronism / therapy

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  • (PMID = 17170615.001).
  • [ISSN] 1524-6175
  • [Journal-full-title] Journal of clinical hypertension (Greenwich, Conn.)
  • [ISO-abbreviation] J Clin Hypertens (Greenwich)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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94. Deshpande A, Munshi M: Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report. Indian J Pathol Microbiol; 2005 Apr;48(2):230-5
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  • [Title] Renal oncocytoma with hyaline globules: cytologic diagnosis by guided fine needle aspiration, a case report.
  • Renal oncocytomas are rare renal parenchymal neoplasms which have a good prognosis.
  • An accurate pre-operative diagnosis by guided fine needle aspiration cytology helps to plan a more conservative surgery.
  • Cytologic findings in a case of renal oncocytoma are presented.
  • Renal oncocytoma has to be distinguished from granular renal cell carcinoma (RCC) and chromophobe cell carcinoma, because of the markedly different prognosis.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / diagnosis. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Needle. Diagnosis, Differential. Female. Humans

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  • (PMID = 16758678.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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95. Johnson NB, Johnson MM, Selig MK, Nielsen GP: Use of electron microscopy in core biopsy diagnosis of oncocytic renal tumors. Ultrastruct Pathol; 2010 Aug;34(4):189-94
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  • [Title] Use of electron microscopy in core biopsy diagnosis of oncocytic renal tumors.
  • The distinction between oncocytoma and chromophobe renal cell carcinoma, important clinically, may be challenging, especially as the tissue sample size decreases.
  • The aim of this study was to examine the value of electron microscopy in differentiating between oncocytoma and chromophobe renal cell carcinoma on formalin fixed paraffin embedded needle core biopsies.
  • Twenty renal needle core biopsies were evaluated.
  • [MeSH-major] Adenoma, Oxyphilic / ultrastructure. Kidney Neoplasms / ultrastructure
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy. Carcinoma, Renal Cell / ultrastructure. Cytoplasmic Vesicles / ultrastructure. Diagnosis, Differential. Female. Humans. Male. Microscopy, Electron, Transmission / methods. Middle Aged. Mitochondria / ultrastructure. Predictive Value of Tests

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  • (PMID = 20594037.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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96. Bahrami A, Truong LD, Shen SS, Krishnan B: Synchronous renal and adrenal masses: an analysis of 80 cases. Ann Diagn Pathol; 2009 Feb;13(1):9-15
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  • [Title] Synchronous renal and adrenal masses: an analysis of 80 cases.
  • Synchronous renal and adrenal masses are uncommon.
  • Although adrenal masses in the context of renal cell carcinoma (RCC) are often suspected as metastasis, other adrenal lesions with different therapeutic and prognostic implications may coexist with RCC.
  • In a retrospective review of 550 radical nephrectomies with ipsilateral adrenalectomy, 80 cases of coexisting renal and adrenal masses were identified.
  • The renal masses included 76 RCCs, 3 oncocytomas, and 1 malignant pheochromocytoma of adrenal gland involving the kidney.
  • Although the gross pathologic impression of adrenal masses in the presence of RCC was metastasis, on histologic examination, 56% of them were found to be benign lesions (mostly adrenal adenoma/hyperplasia), whereas malignant involvement from RCC was seen in 43%.
  • The benign and malignant nature of the adrenal lesions in the context of RCC could not be discriminated based on the size of adrenal mass.
  • Rare unusual combinations of renal and adrenal lesions such as RCC and adrenal histoplasmosis, RCC and adrenal myelolipoma, renal oncocytoma, and adrenal pheochromocytoma are also described.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Glands / pathology. Carcinoma, Renal Cell / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / surgery. Adrenalectomy. Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Nephrectomy. Pheochromocytoma / pathology. Pheochromocytoma / surgery. Retrospective Studies

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  • (PMID = 19118776.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Skinnider BF, Folpe AL, Hennigar RA, Lim SD, Cohen C, Tamboli P, Young A, de Peralta-Venturina M, Amin MB: Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. Am J Surg Pathol; 2005 Jun;29(6):747-54
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  • [Title] Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors.
  • Adult renal epithelial neoplasms (RENs) comprise several distinct clinicopathologic entities with potential prognostic and therapeutic differences.
  • Individual cases can show overlapping morphologic features, necessitating the use of ancillary methods.
  • RENs (including clear cell [conventional] renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, renal oncocytoma, collecting duct carcinoma (CDC), renal medullary carcinoma (RMC), urothelial carcinoma, metanephric adenoma (MA), tubulocystic carcinoma (TC) (also known as low-grade collecting duct carcinoma), and mucinous tubular and spindle cell carcinoma) were immunostained for CK subtypes (CK5/CK6, 7, 8, 13, 14, 17, 18, 19, 20), high molecular weight CKs 1, 5, 10, 14 (HMWCK), and vimentin (Vim).
  • The expression pattern of normal kidney was also examined and correlated with RENs.
  • Clear cell RCCs typically showed a restricted expression pattern of CK8, CK18 and Vim.
  • [MeSH-major] Keratins / biosynthesis. Kidney / metabolism. Kidney Neoplasms / metabolism. Vimentin / biosynthesis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans

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  • [CommentIn] Am J Surg Pathol. 2006 Oct;30(10):1337 [17001169.001]
  • (PMID = 15897741.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vimentin; 68238-35-7 / Keratins
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98. Buła G, Waler J, Niemiec A, Koziołek H, Bichalski W, Gawrychowski J: Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy. Endokrynol Pol; 2010 Sep-Oct;61(5):427-9
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  • [Title] Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy.
  • RESULTS: Among 7 patients with thyroid metastases from renal clear cell carcinoma, as diagnosed postoperatively, cytology of the thyroid material obtained through FNA revealed follicular tumour in 3 (43%) patients, tumour cells in 2 (28.5%) and atypical cells in the other 2 (28.5%).
  • Intraoperative histopathology confirmed the presence of metastasis from renal clear cell carcinoma (1) and indicated thyroid medullary cancer (1), follicular tumour (4), or trabecular adenoma with necrosis (1).
  • Examination of biopsy specimen revealed epithelial cells accompanied by cell atypia in one patient with thyroid metastasis from lung cancer.
  • CONCLUSIONS: Follicular tumour diagnosed by fine needle aspiration biopsy in patients after treatment for other cancers, especially renal clear cell carcinoma, should alert the surgeon to the possibility that it could be a metastasis of this cancer to the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / secondary. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / secondary. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary
  • [MeSH-minor] Adenoma / pathology. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Neuroendocrine. Female. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Middle Aged. Monitoring, Intraoperative / methods

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  • (PMID = 21049452.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Thyroid cancer, medullary
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99. Memeo L, Jhang J, Assaad AM, McKiernan JM, Murty VV, Hibshoosh H, Tong GX, Mansukhani MM: Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma. Am J Clin Pathol; 2007 Feb;127(2):225-9
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  • [Title] Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma.
  • Immunohistochemical staining for cytokeratin 7 (CK7), KIT, and PAX2 expression was performed on 91 renal neoplasms, 37 conventional (clear cell) renal cell carcinomas (CRCCs), 20 papillary RCCs (PRCCs), 11 chromophobe RCCs (ChCs), and 23 oncocytomas, with available karyotypes.
  • These results identify specific staining patterns of the 4 major histologic subtypes of renal neoplasms and raise the question of a relationship between chromosome 10 loss and loss of PAX2 expression in ChC.
  • [MeSH-major] Carcinoma, Renal Cell / chemistry. Keratin-7 / analysis. Kidney Neoplasms / chemistry. PAX2 Transcription Factor / analysis. Proto-Oncogene Proteins c-kit / analysis
  • [MeSH-minor] Adenoma, Oxyphilic / chemistry. Cytogenetic Analysis. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 17210525.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7; 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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100. Hard GC, Seely JC: Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN). Toxicol Pathol; 2005;33(6):641-9
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  • [Title] Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN).
  • There is little guidance in the literature on the spectrum of proliferative tubule lesions in the kidneys of aging rats affected with spontaneously occurring, chronic progressive nephropathy (CPN), or their interpretation.
  • Through accessing 2-year carcinogenicity studies in male F344 rats held in the Archives of the National Toxicology Program, NIEHS, a large number of cases of advanced CPN have been surveyed histopathologically for proliferative tubule lesions, and an attempt made to provide guidelines for discrimination of lesions common to the CPN process, from those representing precursors of neoplasia.
  • Several proliferative lesions were identified as common in advanced CPN with no apparent evidence supporting a role in renal tubule carcinogenesis.
  • It is recommended that these lesions be viewed generically as CPN tubule profiles, and not recorded separately from the diagnosis of CPN.
  • Criteria were developed to distinguish these CPN-associated lesions from atypical tubule hyperplasia, a precursor of adenoma, both of which were also represented in this survey of advanced CPN.
  • [MeSH-major] Adenoma / diagnosis. Aging / pathology. Carcinogens / toxicity. Kidney Diseases / diagnosis. Kidney Neoplasms / diagnosis. Kidney Tubules / pathology. Precancerous Conditions / diagnosis
  • [MeSH-minor] Animals. Carcinogenicity Tests. Chronic Disease. Diagnosis, Differential. Hyperplasia. Male. Practice Guidelines as Topic. Rats. Rats, Inbred F344. Risk Assessment. Staining and Labeling

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  • (PMID = 16207638.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens
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