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1. Szponar A, Yusenko MV, Kovacs G: High-resolution array CGH of metanephric adenomas: lack of DNA copy number changes. Histopathology; 2010 Jan;56(2):212-6
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  • [Title] High-resolution array CGH of metanephric adenomas: lack of DNA copy number changes.
  • AIMS: Previous karyotyping and fluorescence in situ hybridization analysis of metanephric adenomas (MAs) has yielded controversial data.
  • METHODS AND RESULTS: DNA extracted from paraffin blocks of six metanephric adenomas was hybridized onto Agilent oligoarrays with approximately 43,000 in situ synthesized 60-mer oligonucleotide probes that span coding and non-coding sequences with an average spatial resolution of approximately 35 kb.
  • None of the metanephric adenomas showed DNA copy number changes.
  • To confirm our results, DNA extracted from the paraffin block of a chromophobe renal cell carcinoma (RCC) was simultaneously hybridized to one of the four arrays on the same slides as an internal control.
  • CONCLUSIONS: Our high-resolution oligoarray analysis indicates that metanephric adenomas lack DNA copy number alterations.
  • This finding may help to differentiate between metanephric adenomas from Wilms' tumour and papillary renal cell adenoma with overlapping phenotype.
  • [MeSH-major] Adenoma / genetics. DNA Copy Number Variations. Kidney Neoplasms / genetics
  • [MeSH-minor] Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Comparative Genomic Hybridization. Humans

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  • (PMID = 20102400.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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2. Salido M, Lloreta J, Melero C, García M, Placer J, Espinet B, Villa O, Bielsa O, Gelabert-Mas A, Serrano S, Solé F: Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. Cancer Genet Cytogenet; 2005 Dec;163(2):160-3
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  • [Title] Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma.
  • We report the case of a 43-year-old male with multiple tumor foci showing microscopic features of chromophobe renal carcinoma (ChRCC) arising in an oncocytoma.
  • FISH techniques on paraffin tissue sections may help to identify genetic aberrations such as CCND1 rearrangement in order to establish a diagnosis of oncocytoma.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 8. Kidney Neoplasms / genetics
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic. Chromosome Banding. Cyclin D1 / genetics. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Karyotyping. Male


3. Portugal R, Barroca H: Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour. Cytopathology; 2008 Apr;19(2):80-5
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  • [Title] Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour.
  • Wilms' Tumour (WT) is the most common kidney tumour in childhood, this fact and the embryonic complexity of WT create, whenever one of its three classical components predominates in cytologic smears, difficulties in the differential diagnoses with other less common entities.
  • In the present study, we review the cytological and immunohistochemical characteristics of three children renal tumours, a Clear Cell Sarcoma of the Kidney (CCSK-case1), a Cellular Mesoblastic Nephroma (CMN-case2) and a Metanephric Adenoma (MA-case3) and compare them, for differential diagnostic purposes, with smears of blastematous, mesenchymal and epithelial predominant WTs, previously diagnosed in our Department.
  • The presence of moderate amount of blue pale cytoplasm in neoplastic cells (case1), the presence of tightly cohesive, bland, spindle tumour cells (case2) and the identification of small, well differentiated epithelial tubules with psammoma bodies in case 3, were the main morphologic characteristics that we think represent the most important elements for distinguishing our cases from a WT.
  • Summing up, these three cases demonstrate that cytopathologists should be aware of the occurrence of uncommon renal neoplasms in childhood and should be acquainted with their characteristics, in order to avoid false diagnoses.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Nephroma, Mesoblastic / pathology. Sarcoma, Clear Cell / pathology. Wilms Tumor / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor. Biopsy, Fine-Needle. Child. Child, Preschool. Cytoplasm / chemistry. Cytoplasm / pathology. Diagnosis, Differential. Female. Humans. Inclusion Bodies / chemistry. Inclusion Bodies / pathology. Infant, Newborn. Male. Pregnancy

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  • (PMID = 17681013.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Chung SD, Huang KH, Yu HJ, Wu KD, Chueh SC: Diagnosis of bilateral aldosterone-producing adenomas. Kidney Int; 2007 Jul;72(2):228
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  • [Title] Diagnosis of bilateral aldosterone-producing adenomas.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / metabolism. Adrenal Gland Neoplasms / diagnosis

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  • [CommentIn] Kidney Int. 2008 Feb;73(3):362-3; author reply 363-4 [18195700.001]
  • (PMID = 17625586.001).
  • [ISSN] 0085-2538
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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5. Rossi GP, Pessina AC, Heagerty AM: Primary aldosteronism: an update on screening, diagnosis and treatment. J Hypertens; 2008 Apr;26(4):613-21
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  • [Title] Primary aldosteronism: an update on screening, diagnosis and treatment.
  • BACKGROUND: Primary aldosteronism is much more common than previously held; it implies an excessive organ damage to the heart, vessels and kidney, which translates into an excess of cardiovascular events.
  • These two features, along with the fact that the arterial hypertension and the hypokalemia can be corrected with a timely diagnosis and an appropriate therapy, warrant an aggressive diagnostic approach in hypertensive patients.
  • At variance, the identification of primary aldosteronism subtypes, for example, the differentiation of patients with an aldosterone-producing adenoma from those with idiopathic hyperaldosteronism should be undertaken at tertiary referral centres.
  • Thus, an aggressive diagnostic approach is mandatory at least in some subgroups of hypertensive patients who are at higher prior risk of primary aldosteronism or can benefit more from an accurate diagnosis.
  • [MeSH-major] Hyperaldosteronism / diagnosis. Hyperaldosteronism / therapy. Hypertension / diagnosis. Hypertension / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Mass Screening. Prevalence

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  • [CommentIn] J Hypertens. 2008 Aug;26(8):1708-9; author reply 1709-11 [18622252.001]
  • (PMID = 18327065.001).
  • [ISSN] 0263-6352
  • [Journal-full-title] Journal of hypertension
  • [ISO-abbreviation] J. Hypertens.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 127
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6. Paner GP, Turk TM, Clark JI, Lindgren V, Picken MM: Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes. Arch Pathol Lab Med; 2005 Oct;129(10):1317-21
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  • [Title] Passive seeding in metanephric adenoma: a review of pseudometastatic lesions in perinephric lymph nodes.
  • However, rarely, inconsequential passive transport of benign neoplastic cells to the lymph node can occur and may cause confusion as to the nature of the neoplasm (ie, malignant vs benign).
  • We describe a 10-cm right renal metanephric adenoma incidentally discovered in a 30-year-old woman during cesarean section for a triplet pregnancy.
  • Subsequent nephrectomy following an equivocal needle biopsy diagnosis showed histologic features classic for metanephric adenoma, including the lack of cytologic atypia and mitoses.
  • The tumor proliferation index with Ki-67 was only 3% to 5% and the proliferating cell nuclear antigen index was 0%.
  • We postulate that the lymph node inclusions found in this case represent passive transport of neoplastic cells to the lymph node following manipulation of the renal mass.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology. Lymph Nodes / pathology. Neoplasm Seeding
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Cytogenetic Analysis. Diagnosis, Differential. Female. Humans. Kidney / pathology. Neoplasm Metastasis / diagnosis. Pregnancy. Wilms Tumor / diagnosis

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  • (PMID = 16196523.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Hansel DE: Genetic alterations and histopathologic findings in familial renal cell carcinoma. Histol Histopathol; 2006 04;21(4):437-44
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  • [Title] Genetic alterations and histopathologic findings in familial renal cell carcinoma.
  • Renal cell carcinoma is increasing in frequency in the United States and is often detected late in the course of disease due to nonspecific symptoms.
  • A subset of renal cell carcinoma is attributable to familial or hereditary syndromes, including von Hippel-Lindau and Birt-Hogg-Dubé syndromes, among others.
  • This review describes the various subtypes of renal cell carcinoma and the familial syndromes associated with these tumors.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Gene Expression Regulation, Neoplastic. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Chromosome Disorders / genetics. Chromosome Disorders / pathology. Chromosomes, Human, Pair 3. Disease Progression. Humans. Leiomyomatosis / genetics. Leiomyomatosis / pathology. Neoplastic Syndromes, Hereditary / genetics. Neoplastic Syndromes, Hereditary / pathology. Proteins / genetics. Proto-Oncogene Proteins. Translocation, Genetic. Tumor Suppressor Proteins / genetics. von Hippel-Lindau Disease / genetics. von Hippel-Lindau Disease / pathology


8. Mei H, Zheng L, Zhou C, Tong Q: Metanephric adenoma in a 2-year-old child: case report and immunohistochemical observations. J Pediatr Hematol Oncol; 2010 Aug;32(6):489-93
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  • [Title] Metanephric adenoma in a 2-year-old child: case report and immunohistochemical observations.
  • SUMMARY: Renal metanephric adenoma (MA) is an extremely rare benign tumor, especially in children under the age of 12 years old.
  • Magnetic resonance scan revealed a mass of right kidney that was hypointense and hyperintense on T1- and T2-weighted images, respectively.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology

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  • (PMID = 20539237.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Tienari J, Lehtonen S, Lehtonen E: CD2-associated protein in human urogenital system and in adult kidney tumours. Virchows Arch; 2005 Apr;446(4):394-401
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  • [Title] CD2-associated protein in human urogenital system and in adult kidney tumours.
  • We studied expression of CD2-associated protein (CD2AP) in human urogenital system and in adult kidney tumours.
  • In the cortex of normal kidney, CD2AP was expressed in all types of tubules and in the glomeruli.
  • Clear cell renal cell carcinoma (RCC) (n=63) showed a weak expression.
  • Type-I papillary RCCs (n=4) and papillary adenomas (n=3) were negative.
  • The results show that CD2AP displays a specific expression pattern in human urogenital organs and that distinct expression is shown in several types of kidney tumours but not in type-I papillary RCCs or in papillary adenomas.
  • [MeSH-major] Adenoma / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Proteins / metabolism. Urogenital System / metabolism. src Homology Domains / physiology

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  • (PMID = 15785926.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / CD2-associated protein; 0 / Cytoskeletal Proteins; 0 / Proteins
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10. Chiou TT, Chiang PH, Fuh M, Liu RT, Lee WC, Lee WC, Ng HY, Tsai YC, Chuang FR, Huang CC, Lee CT: Factors determining cardiovascular and renal outcomes after adrenalectomy in patients with aldosterone-producing adrenal adenoma. Tohoku J Exp Med; 2009 May;218(1):17-24
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  • [Title] Factors determining cardiovascular and renal outcomes after adrenalectomy in patients with aldosterone-producing adrenal adenoma.
  • Primary aldosteronism is an important cause of secondary hypertension, because it is potentially curable, especially in case of unilateral aldosterone-producing adrenal adenoma (APA).
  • However, the information is limited concerning the cardiovascular and renal outcomes in this patient population.
  • We studied 52 patients with APA in order to determine the pre-operative and post-operative factors predicting cardiovascular and renal outcomes.
  • Patients whose renal function worsened after adrenalectomy had significantly higher pre-operative plasma active renin levels.
  • Thus, in patients with APA, the presence of LVH is correlated with impaired renal function (lower eGFR).
  • In conclusion, pre-operative BP and post-operative plasma aldosterone are important in predicting post-adrenalectomy hypertension, and a lower pre-operative plasma renin predicts the improvement in renal function after adrenalectomy.
  • [MeSH-major] Adrenal Cortex Neoplasms. Adrenalectomy. Adrenocortical Adenoma. Aldosterone / blood. Cardiovascular System / metabolism. Hypertension. Kidney

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  • (PMID = 19398869.001).
  • [ISSN] 1349-3329
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone
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11. Rocca PC, Brunelli M, Gobbo S, Eccher A, Bragantini E, Mina MM, Ficarra V, Zattoni F, Zamò A, Pea M, Scarpa A, Chilosi M, Menestrina F, Bonetti F, Eble JN, Martignoni G: Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. Mod Pathol; 2007 Jul;20(7):722-8
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  • [Title] Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study.
  • S100A1 is a calcium-binding protein, which has been recently found in renal cell neoplasms.
  • We evaluated the diagnostic utility of immunohistochemical detection of S100A1 in 164 renal cell neoplasms.
  • Forty-one clear cell, 32 papillary, and 51 chromophobe renal cell carcinomas, and 40 oncocytomas, 164 samples of normal renal parenchyma adjacent to the tumors and 13 fetal kidneys were analyzed.
  • The levels of S100A1 mRNA detected by quantitative RT-PCR analysis of frozen tissues from seven clear cell, five papillary, and six chromophobe renal cell carcinomas, four oncocytomas, and nine samples of normal renal tissues adjacent to neoplasms were compared with the immunohistochemical detection of protein expression.
  • Clear cell and papillary renal cell carcinomas showed positive reactions for S100A1 in 30 out of 41 tumors (73%) and in 30 out of 32 (94%) tumors, respectively.
  • Thirty-seven renal oncocytomas out of 40 (93%) were positive for S100A1, whereas 48 of 51 (94%) chromophobe renal cell carcinomas were negative.
  • S100A1 mRNA was detected by RT-PCR in all normal kidneys and renal cell neoplasms, although at very different levels.
  • Statistical analyses comparing the different expression of S100A1 in clear cell and chromophobe renal cell carcinomas observed by immunohistochemical and RT-PCR methods showed significant values (P<0.001), such as when comparing by both techniques the different levels of S100A1 expression in chromophobe renal cell carcinomas and oncocytomas (P<0.001).
  • Our study shows that S100A1 protein is expressed in oncocytomas, clear cell and papillary renal cell carcinomas but not in chromophobe renal cell carcinomas.
  • Its immunodetection is potentially useful for the differential diagnosis between chromophobe renal cell carcinoma and oncocytoma.
  • Further, S100A1 protein expression is constantly detected in the normal parenchyma of the adult and fetal kidney.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. S100 Proteins / genetics
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Kidney / chemistry. Kidney / metabolism. Kidney / pathology. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Sensitivity and Specificity

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  • (PMID = 17483815.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / S100 Proteins; 0 / S100A1 protein
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12. Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC: Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest; 2009 Apr;119(4):876-85
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  • Studies have shown that COX-2-derived PGE2 promotes CRC progression, and both nonselective COX inhibitors (NSAIDs) and selective COX-2 inhibitors (such as glucocorticoids) reduce the number and size of colonic adenomas.
  • We found that expression of 11beta-hydroxysteroid dehydrogenase type II (11betaHSD2), which converts active glucocorticoids to inactive keto-forms, increased in human colonic and Apc+/min mouse intestinal adenomas and correlated with increased COX-2 expression and activity.
  • Furthermore, pharmacologic inhibition or gene silencing of 11betaHSD2 inhibited COX-2-mediated PGE2 production in tumors and prevented adenoma formation, tumor growth, and metastasis in mice.

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  • (PMID = 19307727.001).
  • [ISSN] 1558-8238
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA97386; United States / NIDDK NIH HHS / DK / DK48831; United States / NCI NIH HHS / CA / R01 CA094849; United States / NIDDK NIH HHS / DK / P50 DK039261; United States / NIDDK NIH HHS / DK / R01 DK048831; United States / NIDDK NIH HHS / DK / DK39261; United States / NIDDK NIH HHS / DK / R01 DK074359; United States / NCI NIH HHS / CA / R01 CA097386; United States / NIDDK NIH HHS / DK / DK74359; United States / NCI NIH HHS / CA / CA94849; United States / NIDDK NIH HHS / DK / DK62794; United States / NIDDK NIH HHS / DK / R01 DK062794
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Enzyme Inhibitors; 0 / RNA, Small Interfering; 0 / Receptors, Glucocorticoid; 6FO62043WK / Glycyrrhizic Acid; EC 1.1.1.146 / 11-beta-Hydroxysteroid Dehydrogenase Type 2; EC 1.14.99.- / Ptgs2 protein, mouse; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
  • [Other-IDs] NLM/ PMC2662561
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13. Pusiol T, Franceschetti I, Scialpi M, Piscioli I, Tardio ML: Electron microscopy: the gold standard in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma. Anal Quant Cytol Histol; 2010 Feb;32(1):58-60
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  • [Title] Electron microscopy: the gold standard in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma.


14. Nagashima Y, Mitsuya T, Shioi KI, Noguchi S, Kishida T, Hamano A, Ohgo Y, Tsuura Y, Ogawa T, Aoki I, Yao M: Renal oncocytosis. Pathol Int; 2005 Apr;55(4):210-5
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  • [Title] Renal oncocytosis.
  • Renal oncocytosis is a rare disorder in which numerous oncocytic nodules develop in the kidney.
  • Nineteen years previously she had developed a tumorous lesion in the right kidney, which had been diagnosed as oncocytoma with laparotomic biopsy.
  • Recently the kidney was removed because of enlargement of the tumor.
  • The renal parenchyma was entirely replaced with numerous brownish nodules.
  • Based on these findings, the lesion was diagnosed as renal oncocytosis.
  • Despite the rare occurrence pathologists and urologists should be aware of renal oncocytosis, as a precursor lesion of renal oncocytoma and chromophobe renal cell carcinoma.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Kidney / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Cadherins / analysis. DNA Mutational Analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-7. Keratins / analysis. Microscopy, Electron. Middle Aged. Mucin-1 / analysis. Neoplasms, Multiple Primary / pathology. Proteins / genetics. Proto-Oncogene Proteins. Tumor Suppressor Proteins. Vimentin / analysis

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  • (PMID = 15826248.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cadherins; 0 / FLCN protein, human; 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Mucin-1; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 21
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15. Chu PG, Lau SK, Weiss LM, Jiang Z: Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney. Virchows Arch; 2009 Oct;455(4):389-94
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  • [Title] Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidney.
  • We report a mucinous borderline tumor arising from a mixed epithelial and stromal tumor of left kidney (MESTK).
  • The patient had a cytoscopy with a retrograde pyelogram, which indicated a dilated left kidney with a central mass lesion.
  • Cross-sections of left kidney showed a 4.5 x 3.5 x 1.5 cm ill-defined cystic lesion with mucinous and solid areas.
  • In areas, the mucinous epithelium showed complex proliferation with stratification, papillae formation, and nuclear atypia, resembling that of an ovarian mucinous borderline tumor, a colorectal tubular adenoma, or a low-grade appendiceal mucinous carcinoma.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Kidney Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology

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  • [Cites] J Urol. 2001 Oct;166(4):1381-2 [11547080.001]
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  • (PMID = 19756727.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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16. Mai KT, Dhamanaskar P, Belanger E, Stinson WA: Hybrid chromophobe renal cell neoplasm. Pathol Res Pract; 2005;201(5):385-9
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  • [Title] Hybrid chromophobe renal cell neoplasm.
  • Hybrid renal cell neoplasms (HRCNs) containing areas of tumor cells displaying cytological features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO) have been recently described in patients with renal oncocytosis and Birt-Hogg-Dube (BHD) syndrome (autosomal dominant genodermatosis).
  • We reviewed 425 consecutive renal cell carcinomas (RCC), 18 CHRCC, six HRCN, and 25 RO.
  • None of the study cases had microscopic RO, as commonly seen in renal oncocytosis, or were associated with BHD syndrome Sporadic HRCN accounted for 1% of RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology

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  • (PMID = 16047948.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / KRT7 protein, human; 0 / Keratin-7; 0 / Vimentin; 68238-35-7 / Keratins
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17. Johnson NB, Johnson MM, Selig MK, Nielsen GP: Use of electron microscopy in core biopsy diagnosis of oncocytic renal tumors. Ultrastruct Pathol; 2010 Aug;34(4):189-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of electron microscopy in core biopsy diagnosis of oncocytic renal tumors.
  • The distinction between oncocytoma and chromophobe renal cell carcinoma, important clinically, may be challenging, especially as the tissue sample size decreases.
  • The aim of this study was to examine the value of electron microscopy in differentiating between oncocytoma and chromophobe renal cell carcinoma on formalin fixed paraffin embedded needle core biopsies.
  • Twenty renal needle core biopsies were evaluated.
  • [MeSH-major] Adenoma, Oxyphilic / ultrastructure. Kidney Neoplasms / ultrastructure
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy. Carcinoma, Renal Cell / ultrastructure. Cytoplasmic Vesicles / ultrastructure. Diagnosis, Differential. Female. Humans. Male. Microscopy, Electron, Transmission / methods. Middle Aged. Mitochondria / ultrastructure. Predictive Value of Tests

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  • (PMID = 20594037.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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18. Sato Y, Mukai M, Sasaki M, Kitao A, Yoneda N, Kobayashi D, Imamura Y, Nakanuma Y: Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease. Pathol Int; 2009 Mar;59(3):201-4
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  • [Title] Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease.
  • A case of intraductal papillary-mucinous neoplasm (IPMN) of the pancreas associated with polycystic liver and kidney disease is reported.
  • Pancreatoduodenectomy was performed, and a pathological diagnosis of intraductal papillary-mucinous adenoma of branch duct type of the pancreas was made.
  • He died of renal failure and hepatic failure due to recurrent cholangitis 12 years after the operation.
  • The kidneys showed that the cysts originated from all segments of the renal tubule.
  • The autopsy findings suggested that the patient had suffered from autosomal-dominant polycystic kidney disease (ADPKD), but he did not have a family history of ADPKD.
  • This case demonstrates that IPMN of the pancreas can occur as an extrarenal complication in patients with polycystic liver and kidney disease.
  • [MeSH-major] Adenoma / complications. Liver Diseases / complications. Pancreatic Neoplasms / complications. Polycystic Kidney, Autosomal Dominant / complications


19. Montenegro F, Martin R, Lourenço DM Jr: The parathyroids and the kidney: Fuller Albright revisited. World J Surg; 2009 Feb;33(2):246-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The parathyroids and the kidney: Fuller Albright revisited.
  • [MeSH-major] Adenoma / surgery. Creatinine / metabolism. Hyperparathyroidism / surgery. Parathyroid Neoplasms / surgery. Parathyroidectomy / methods

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  • [Cites] Acta Chir Scand Suppl. 1958;114(Suppl 229):1-56 [13532328.001]
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  • (PMID = 19020930.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] AYI8EX34EU / Creatinine
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20. Kato N, Honma K, Hojo H, Sasou S, Matsuzaki O, Motoyama T: KIT expression in normal and neoplastic renal tissues: immunohistochemical and molecular genetic analysis. Pathol Int; 2005 Aug;55(8):479-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] KIT expression in normal and neoplastic renal tissues: immunohistochemical and molecular genetic analysis.
  • Renal chromophobe cell carcinomas (ChCC) and oncocytomas express KIT.
  • In the normal kidney, however, the expression and localization of KIT are unclear.
  • KIT expression in angiomyolipoma and congenital mesoblastic nephroma (CMN), is still controversial. c-kit mutations are reportedly rare in ChCC, but there is little information in other renal neoplasms, and no reported data on mutations of platelet-derived growth factor receptor (PDGFR).
  • In order to address these issues the authors examined five ChCC, five oncocytomas, seven papillary cell carcinomas, two collecting duct carcinomas, 12 angiomyolipomas, and three CMN, as well as 10 normal renal tissues.
  • In the normal kidney KIT was specifically expressed in the distal nephrons.
  • [MeSH-major] Kidney / metabolism. Kidney Neoplasms / pathology. Proto-Oncogene Proteins c-kit / genetics
  • [MeSH-minor] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / metabolism. Adenoma, Oxyphilic / pathology. Angiomyolipoma / genetics. Angiomyolipoma / metabolism. Angiomyolipoma / pathology. Carcinoma, Papillary / genetics. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. DNA Mutational Analysis. Gene Expression. Humans. Immunohistochemistry. Kidney Tubules, Collecting / chemistry. Kidney Tubules, Collecting / metabolism. Kidney Tubules, Collecting / pathology. Nephroma, Mesoblastic / genetics. Nephroma, Mesoblastic / metabolism. Nephroma, Mesoblastic / pathology. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Receptor, Platelet-Derived Growth Factor alpha / biosynthesis. Receptor, Platelet-Derived Growth Factor alpha / genetics

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  • (PMID = 15998375.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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21. Lin CJ, Wu CJ, Chen YC, Liu HC, Chen HH: Mediastinal ectopic parathyroid adenoma in a hemodialysis patient. Kidney Int; 2007 Oct;72(7):902-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal ectopic parathyroid adenoma in a hemodialysis patient.
  • [MeSH-major] Adenoma / diagnosis. Hyperparathyroidism, Secondary / etiology. Mediastinal Neoplasms / diagnosis. Parathyroid Neoplasms / diagnosis. Renal Dialysis

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  • (PMID = 17882250.001).
  • [ISSN] 0085-2538
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Bach AM, Zhang J: Contemporary radiologic imaging of renal cortical tumors. Urol Clin North Am; 2008 Nov;35(4):593-604; vi
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  • [Title] Contemporary radiologic imaging of renal cortical tumors.
  • Contemporary radiologic imaging has resulted in an increasing number of smaller renal cortical tumors being identified.
  • The ability of imaging to classify these tumors is limited, although certain features may help classify the renal cortical neoplasm.
  • The important role of radiologic imaging in tumor detection, characterization, staging, and follow-up of patients who have renal cortical tumors is reviewed in this article.
  • [MeSH-major] Carcinoma, Renal Cell / radiography. Diagnostic Imaging / methods. Kidney Cortex / pathology. Kidney Cortex / radiography. Kidney Neoplasms / pathology. Kidney Neoplasms / radiography
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / radiography. Adenocarcinoma, Clear Cell / ultrasonography. Adenoma, Chromophobe / diagnosis. Adenoma, Chromophobe / radiography. Adenoma, Chromophobe / ultrasonography. Female. Humans. Magnetic Resonance Imaging. Male. Radiographic Image Enhancement. Tomography, X-Ray Computed

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  • (PMID = 18992613.001).
  • [ISSN] 0094-0143
  • [Journal-full-title] The Urologic clinics of North America
  • [ISO-abbreviation] Urol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 104
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23. Sokolova IA, Hes O, Michal M, Matsko DE: [Small-cell variant of renal oncocytoma]. Arkh Patol; 2007 Sep-Oct;69(5):34-6
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  • [Title] [Small-cell variant of renal oncocytoma].
  • Renal oncocytoma is a distinct benign tumor accounting for approximately 3-5% of all renal tumors.
  • Here, 1 case of renal oncocytoma with a domination of small cells is reported (the so-called "oncoblasts") arising in elderly woman.
  • The term "small-cell variant of renal oncocytoma" was proposed for these cases.
  • The unusual extensive small-cell component of the tumor may represent a potential diagnostic pitfall for primary or metastatic malignant small cell tumors.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Small Cell / pathology. Cytoplasm / pathology. Kidney Neoplasms / pathology. Mitochondria / pathology

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  • (PMID = 18074818.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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24. Azabdaftari G, Alroy J, Banner BF, Ucci A, Bhan I, Cheville JC: S100 protein expression distinguishes metanephric adenomas from other renal neoplasms. Pathol Res Pract; 2008;204(10):719-23
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  • [Title] S100 protein expression distinguishes metanephric adenomas from other renal neoplasms.
  • Metanephric adenoma is a benign renal neoplasm with morphologic features similar to those of malignant renal neoplasms, such as papillary renal cell carcinoma (RCC) and Wilms' tumor.
  • Different methods have been used to distinguish between metanephric adenoma and papillary RCC and Wilms' tumor.
  • In the current study, we compared the expression of S100 protein in 15 cases of metanephric adenoma, 10 cases of Wilms' tumor, and 13 cases of papillary RCC.
  • Our results revealed strong expression of S100 proteins in all cases of metanephric adenoma, weak expression in two cases of Wilms' tumor, and no expression in any of the cases of papillary RCC.
  • These findings indicate that S100 could be a useful and accessible tool for the diagnosis of metanephric adenoma.
  • [MeSH-major] Adenoma / chemistry. Carcinoma, Renal Cell / chemistry. Kidney Neoplasms / chemistry. S100 Proteins / analysis. Wilms Tumor / chemistry

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  • (PMID = 18621486.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / S100 Proteins
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25. Snyder JM, Lipitz L, Skorupski KA, Shofer FS, Van Winkle TJ: Secondary intracranial neoplasia in the dog: 177 cases (1986-2003). J Vet Intern Med; 2008 Jan-Feb;22(1):172-7
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  • METHODS: Medical records were searched for a diagnosis of intracranial neoplasia in dogs who underwent complete postmortem examination.
  • Of these dogs, those with a diagnosis of primary intracranial neoplasia were excluded.
  • The average age at diagnosis was 9.6 +/- 3.0 years.
  • On postmortem examination, the same tumor that was in the brain was also present in the lung in 84 cases (47%), in the kidney in 62 cases (35%), and in the heart in 55 cases (31%).

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  • (PMID = 18289306.001).
  • [ISSN] 0891-6640
  • [Journal-full-title] Journal of veterinary internal medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Brown AL, Odell EW, Mantle PG: DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A. Exp Toxicol Pathol; 2007 Oct;59(2):85-95
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  • [Title] DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A.
  • DNA ploidy distribution, measured in experimental renal tumours that occurred in twelve ageing male Fischer rats derived from carcinogenicity experiments on ochratoxin A (OTA) in response to chronic dietary exposure, was diploid in all renal adenomas and aneuploid in all carcinomas, correlating with their typical organised and disorganised histopathology, respectively.
  • Aneuploidy was also detected in renal tissue in which karyomegaly, induced by OTA, was analogous to that caused by the fungus Penicillium polonicum.
  • Thus, the experimental rat renal carcinoma could arise within an adenoma directly from certain persistent karyomegalic tubular epithelial cells long after their particular genetic damage has been caused during a protracted period of OTA insult.
  • [MeSH-major] Adenoma / genetics. Aneuploidy. Carcinogens / toxicity. Carcinoma / genetics. DNA, Neoplasm / genetics. Kidney Neoplasms / genetics. Ochratoxins / toxicity
  • [MeSH-minor] Animals. Cell Nucleus / pathology. Diet. Disease Models, Animal. Dose-Response Relationship, Drug. Male. Rats. Rats, Inbred F344

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  • (PMID = 17629687.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinogens; 0 / DNA, Neoplasm; 0 / Ochratoxins; 1779SX6LUY / ochratoxin A
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27. Zhong L: Magnetic resonance imaging in the detection of pancreatic neoplasms. J Dig Dis; 2007 Aug;8(3):128-32
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  • The non-invasive all-in-one MR multi-imaging techniques may provide the comprehensive information needed for the preoperative diagnosis and evaluation of pancreatic neoplasms.
  • Primary tumors of the pancreas may be mainly classified as ductal adenocarcinomas, cystic tumors and islet cell tumors (ICT).
  • Most cystic neoplasms of the pancreas are either microcystic adenomas or mucinous cystic neoplasms.
  • The most frequent tumors to metastasize to the pancreas are cancers of the breast, lung, kidney and melanoma.
  • [MeSH-major] Cholangiopancreatography, Magnetic Resonance. Magnetic Resonance Angiography. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenoma, Islet Cell / diagnosis. Adenoma, Islet Cell / pathology. Humans. Neoplasms, Cystic, Mucinous, and Serous / diagnosis. Neoplasms, Cystic, Mucinous, and Serous / pathology. Pancreas / pathology

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  • (PMID = 17650223.001).
  • [ISSN] 1751-2972
  • [Journal-full-title] Journal of digestive diseases
  • [ISO-abbreviation] J Dig Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 10
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28. Fulciniti F, Losito NS, Botti G, Manola M, Ionna F: Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample. Diagn Cytopathol; 2010 Jun;38(6):430-4
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  • [Title] Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.
  • Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine-needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney.
  • One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy.
  • [MeSH-major] Adenoma, Pleomorphic / blood supply. Adenoma, Pleomorphic / pathology. Infarction / pathology. Parotid Neoplasms / blood supply. Parotid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle / adverse effects. Carcinoma, Mucoepidermoid / pathology. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19894261.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Yusenko MV: Molecular pathology of renal oncocytoma: a review. Int J Urol; 2010 Jul;17(7):602-12
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  • [Title] Molecular pathology of renal oncocytoma: a review.
  • Differentiating renal oncocytoma from its renal cell carcinoma (RCC) mimics, particularly chromophobe RCC, can be difficult, especially when limited tissue is available for evaluation and requires sophisticated microscopic, ultrastructural and immunohistochemical evaluation.
  • In this review, the relevant literature has been reviewed, and supporting data obtained by applying modern microarray-based technologies are discussed with a focus on molecular pathology of renal oncocytoma.
  • Renal oncocytomas are characterized by variable chromosomal patterns.
  • Applying DNA based tools might help in the diagnosis of renal oncocytoma with uncertain histology.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology

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  • [CommentIn] Int J Urol. 2010 Jul;17(7):612-3 [20590945.001]
  • [CommentIn] Int J Urol. 2010 Jul;17(7):613-4 [20590946.001]
  • [ErratumIn] Int J Urol. 2011 Aug;18(8):614
  • (PMID = 20590944.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
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30. Varona A, Blanco L, Perez I, Gil J, Irazusta J, López JI, Candenas ML, Pinto FM, Larrinaga G: Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent. BMC Cancer; 2010;10:193
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  • [Title] Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent.
  • BACKGROUND: Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development.
  • In the present study, the activity and protein and mRNA expression of these glycoproteins were analysed in a subset of clear-cell (CCRCC) and chromophobe (ChRCC) renal cell carcinomas, and in renal oncocytomas (RO).
  • RESULTS: The activity of both glycoproteins was sharply decreased in the three histological types of renal tumors.
  • [MeSH-major] Adenoma, Oxyphilic / enzymology. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / enzymology. Dipeptidyl Peptidase 4 / analysis. Kidney Neoplasms / enzymology. Neprilysin / analysis

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  • (PMID = 20459800.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
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  • [Publication-type] Comparative Study; Journal Article
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  • [Other-IDs] NLM/ PMC2876082
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31. Heitman SJ, Hilsden RJ, Au F, Dowden S, Manns BJ: Colorectal cancer screening for average-risk North Americans: an economic evaluation. PLoS Med; 2010;7(11):e1000370
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  • Given that different FIT assays and collection methods have been previously tested, three distinct FIT testing strategies were considered, on the basis of studies that have reported "low," "mid," and "high" test performance characteristics for detecting adenomas and CRC.
  • Adenoma and CRC prevalence rates were based on a recent systematic review whereas screening adherence, test performance, and CRC treatment costs were based on publicly available data.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / economics. Early Detection of Cancer / economics. Early Detection of Cancer / methods

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  • [ErratumIn] PLoS Med. 2012 Nov;9(11). doi: 10.1371/annotation/0fd49c83-2c6d-42b5-a8c1-45a0aaedaa77
  • (PMID = 21124887.001).
  • [ISSN] 1549-1676
  • [Journal-full-title] PLoS medicine
  • [ISO-abbreviation] PLoS Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2990704
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32. National Toxicology Program: NTP toxicology and carcinogenesis studies of 5-(Hydroxymethyl)-2-furfural (CAS No. 67-47-0) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Jun;(554):7-13, 15-9, 21-31 passim
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  • The incidences of minimal to mild cytoplasmic alteration of the kidney were significantly increased in males administered 188 mg/kg or greater.
  • The incidences of hepatocellular adenoma were significantly increased in 188 and 375 mg/kg females.
  • There was some evidence of carcinogenic activity of 5-(hydroxymethyl)-2-furfural in female B6C3F1 mice based on increased incidences of hepatocellular adenoma in the 188 and 375 mg/kg groups.

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  • (PMID = 20725154.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 70ETD81LF0 / 5-hydroxymethylfurfural; DJ1HGI319P / Furaldehyde
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33. Veroux M, Giuffrida G, Gagliano M, Giaquinta A, Tallarita T, Sorbello M, Corona D, Zerbo D, Vizcarra D, Scriffignano V, Cannizzaro MA, Veroux P: Evaluation of thyroid disease in kidney transplantation candidates: management and follow-up. Transplant Proc; 2009 May;41(4):1142-4
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  • [Title] Evaluation of thyroid disease in kidney transplantation candidates: management and follow-up.
  • INTRODUCTION: Diagnosis of thyroid disease is fundamental in the evaluation of patients awaiting kidney transplantation.
  • We analyzed the incidence of thyroid disease in patients with end-stage renal disease (ESRD) and evaluated its evolution before and after kidney transplantation.
  • PATIENTS AND METHODS: Between January 2000 and May 2008, we evaluated 323 candidates for kidney transplantation.
  • Patients with thyroid cancer were considered eligible for kidney transplantation after at least 2 years since treatment.
  • RESULTS: One-hundred-four patients with ESRD (44%) had functional or morphologic changes in the thyroid gland.
  • Forty-one patients (17.4%) underwent fine-needle aspiration cytology; 3 demonstrated showed papillary carcinoma; 3, follicular adenomas; 8, uncertain cytologic lesions; and 27, a nodular goiter.
  • Of the 184 transplant recipients, 10 underwent surgery to treat thyroid disease: 8 with multinodular goiter, 1 with micropapillary carcinoma, and 1 with follicular adenoma.
  • Early diagnosis and treatment significantly decreased morbidity and mortality in patients awaiting transplantation.
  • [MeSH-major] Carcinoma, Papillary / complications. Kidney Failure, Chronic / surgery. Kidney Transplantation. Neoplasm Recurrence, Local / complications. Thyroid Neoplasms / epidemiology


34. Ruggeri RM, Calamoneri E, Russo A, Sindoni A, Mondello B, Monaco M, Rosa MA, Baldari S, Benvenga S, Campennì A, Trimarchi F: Supra-acetabular brown tumor due to primary hyperparathyroidism associated with chronic renal failure. ScientificWorldJournal; 2010;10:799-805
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  • [Title] Supra-acetabular brown tumor due to primary hyperparathyroidism associated with chronic renal failure.
  • Her past medical history included chronic renal insufficiency.
  • Serum intact PTH was elevated (1020 pg/ml; normal values, 12-62 pg/ml), but her serum calcium was normal (total=9.4 mg/dl, nv 8.5-10.5; ionized=5.0 mg/dl, nv 4.2-5.4) due to the coexistence of chronic renal failure.
  • 99mTc-MIBI scintigraphy revealed a single focus of sestamibi accumulation in the left retrosternal location, which turned out to be an intrathoracic parathyroid adenoma at surgical exploration.
  • After surgical removal of the parathyroid adenoma, PTH levels decreased to 212 pg/ml.
  • This case is noteworthy because (1) primary hyperparathyroidism was not suspected due to the normocalcemia, likely attributable to the coexistence of chronic renal failure; and (2) it was associated with a brown tumor of unusual location (right supra-acetabular region).
  • [MeSH-major] Bone Neoplasms / diagnosis. Hyperparathyroidism, Primary / complications. Kidney Failure, Chronic / complications


35. Patel NP, Geisinger KR, Zagoria RJ, Bergman S: Fine needle aspiration biopsy of metanephric adenoma: a case report. Acta Cytol; 2009 May-Jun;53(3):327-31
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  • [Title] Fine needle aspiration biopsy of metanephric adenoma: a case report.
  • BACKGROUND: Metanephric adenoma (MA) is a rare, benign renal neoplasm.
  • Regarding treatment, radioflrequency ablation (RFA) is an emerging alternative to surgical resection of renal neoplasms in appropriately selected patients.
  • CASE: A 49-year-old woman had a 3.3-cm cortical mass in the left kidney.
  • The aspirate smears displayed multiple aggregates of benign-appearing, tightly packed and overlapping nuclei surrounded by basement membrane- type material.
  • Although the differential diagnosis included adult Wilms' tumor and papillary renal cell carcinoma, the bland morphology and IHC staining pattern strongly favored a neoplasm consistent with MA.
  • CONCLUSION: FNAB can be used to diagnose most renal neoplasms.
  • A diagnosis of MA can be suggested on FNAB in the context of appropriate cytomorphology, IHC staining and cytogenetic analysis.
  • [MeSH-major] Adenoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Antigens, CD57 / analysis. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Catheter Ablation / methods. Diagnosis, Differential. Female. Humans. Middle Aged. Minimally Invasive Surgical Procedures. Treatment Outcome. WT1 Proteins / analysis. Wilms Tumor / diagnosis

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  • (PMID = 19534278.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD57; 0 / Biomarkers, Tumor; 0 / WT1 Proteins
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36. Lauter K, Arnold A: Analysis of CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, as a candidate tumor suppressor gene in primary and severe secondary/tertiary hyperparathyroidism. J Bone Miner Res; 2009 Jan;24(1):102-4
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  • CYP27B1, encoding 25-hydroxyvitamin D-1alpha-hydroxylase, converts 25-hydroxyvitamin D to its active form, 1,25-dihydroxyvitamin D, and is expressed primarily in the kidney but also in nontraditional sites including the parathyroid glands.
  • Whereas the role of locally produced 1,25-dihydroxyvitamin D is not yet clear, it is possible that it contributes importantly to vitamin D-mediated inhibition of parathyroid cell growth, so CYP27B1 can be considered a candidate parathyroid tumor suppressor gene in that its acquired inactivation in a parathyroid cell could confer a tumorigenic growth advantage.
  • Because detection of inactivating mutations is the central criterion for validating a candidate tumor suppressor, we directly sequenced the coding region and all splice sites of CYP27B1 in 31 sporadic parathyroid adenomas and 31 parathyroid tumors from patients with refractory secondary/tertiary hyperparathyroidism.
  • Our findings indicate that CYP27B1 does not commonly serve as a classical tumor suppressor gene in the development of sporadic parathyroid adenomas or of refractory secondary/tertiary hyperparathyroidism.

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  • (PMID = 18767934.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / F30 DK081270; United States / NIGMS NIH HHS / GM / T32 GM008607; United States / NIDDK NIH HHS / DK / F30 DK081270-01; United States / NIGMS NIH HHS / GM / T32-GM008607
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Calcitriol; EC 1.14.- / 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • [Other-IDs] NLM/ PMC2689078
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37. Bozkurt SU, Erbarut I, Yazici C, Kaya H, Türkeri L: Nephrogenic adenoma of the ureter: case report. Int Urol Nephrol; 2007;39(1):65-9
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  • [Title] Nephrogenic adenoma of the ureter: case report.
  • Nephrogenic adenoma is a rare metaplastic benign lesion of urothelium in response to genitourinary tract procedures, chronic infection, trauma, urinary calculi and immunosuppressive therapy after renal transplantation.
  • We report a case of nephrogenic adenoma arising from the lower end of the right ureter with clinical and radiological features suspicious of carcinoma.
  • [MeSH-major] Adenoma / pathology. Ureteral Neoplasms / pathology
  • [MeSH-minor] Humans. Keratin-7 / metabolism. Kidney Tubules / pathology. Magnetic Resonance Imaging. Male. Middle Aged. Urography. Urothelium / pathology

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  • (PMID = 17268911.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratin-7
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38. Nigro M, Piscioli I, Franceschetti I, Barberini F, Lupattelli L, Scialpi M: Simultaneous occurrence of renal oncocytoma and B small cell lymphoma in the same kidney: report of two cases. Urol Int; 2009;83(2):242-5
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  • [Title] Simultaneous occurrence of renal oncocytoma and B small cell lymphoma in the same kidney: report of two cases.
  • Two cases of simultaneous occurrence of oncocytoma (OC) associated with small B-cell lymphoma in the same kidney were investigated.
  • Computed tomography, performed for staging purposes, incidentally revealed a small hypo- and hyperattenuating renal mass.
  • Diagnosis of OC was performed on the specimen by morphology, immunohistochemistry and electron microscopy.
  • The occurrence of OC and non-Hodgkin lymphoma in the same kidney has never been reported.
  • However, when some solid, small hyper- or hypoattenuating masses occur in the kidney, the diagnosis by computed tomography alone is always a challenge and other malignant neoplasms may be considered.
  • Immunohistochemistry and electron microscopy allow a definitive diagnosis of OC.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms. Lymphoma, B-Cell. Neoplasms, Multiple Primary

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19752626.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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39. D'Agostini F, Balansky R, Steele VE, Ganchev G, Pesce C, De Flora S: Preneoplastic and neoplastic lesions in the lung, liver and urinary tract of mice exposed to environmental cigarette smoke and UV light since birth. Int J Cancer; 2008 Dec 1;123(11):2497-502
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  • When the experiment was stopped, after 330 days, the number of lung adenomas was higher in ECS-exposed mice as compared to sham-exposed mice, but such increase was statistically significant only in mice co-exposed to smoke and halogen light mimicking solar irradiation.
  • In contrast, induction by ECS of alterations in the urinary tract, such as microadenomas and adenomas in renal pelvis and kidney, papillary hyperplasia of urothelium, and urinary bladder papillomas, were unrelated to the exposure time after birth.

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  • (PMID = 18770867.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] None / None / / N01 CN053301; United States / NCI NIH HHS / CA / N01CN53301; United States / NCI NIH HHS / CN / N01 CN053301; United States / NCI NIH HHS / CN / N01-CN53301
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tobacco Smoke Pollution
  • [Other-IDs] NLM/ NIHMS70896; NLM/ PMC2583251
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40. Jeon HG, Kim DS, Jeoung HB, Han SW, Hong CH, Im YJ, Oh YT, Kim MJ, Han WK: Pediatric laparoendoscopic single-site partial nephrectomy: initial report. Urology; 2010 Jul;76(1):138-41
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  • METHODS: On May 22, 2009, we performed LESS partial nephrectomy on a 7-year-old girl with a 3.5-cm renal mass.
  • LESS partial nephrectomy was performed with hilar clamping and suturing of the renal defect.
  • Histopathological analysis revealed a 3.5-cm metanephric adenoma with a clean surgical margin.
  • On follow-up, Doppler ultrasound sonography showed the kidney was normal in appearance, size, and echogenicity.
  • Split renal function was calculated to be 47.5% for the left kidney upon dimercaptosuccinic acid renal scintigraphy.
  • CONCLUSIONS: LESS partial nephrectomy was safe and feasible for removal of a renal mass in a child.
  • [MeSH-major] Adenoma / surgery. Kidney Neoplasms / surgery. Laparoscopy / methods. Nephrectomy / methods

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Urology. 2010 Jul;76(1):141-2; author reply 142 [20599108.001]
  • (PMID = 20494417.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. National Toxicology Program: NTP technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (Gavage studies). Natl Toxicol Program Tech Rep Ser; 2006 May;(529):4-168
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  • Hepatic Cell Proliferation Data: No significant differences in hepatocellular labeling index were observed between the vehicle control and dosed groups at any of the interim evaluations.
  • Absolute kidney weights of all exposed groups and the relative kidney weight of 3,000 microg/kg rats were significantly increased at week 53.
  • The incidences of oval cell hyperplasia and pigmentation of the liver were significantly increased in the 3,000 microg/kg core study group.
  • A single hepatocellular adenoma was observed in the 3,000 microg/kg core study group.
  • At 53 weeks, sporadic incidences of minimal to mild follicular cell hypertrophy of the thyroid gland occurred in all groups (except 10 microg/kg).
  • At 2 years, the incidences of minimal to mild follicular cell hypertrophy were significantly increased in the 300 microg/kg and 3,000 microg/kg (core and stop-exposure) groups.
  • [MeSH-minor] Adenoma, Bile Duct / chemically induced. Adenoma, Bile Duct / pathology. Administration, Oral. Animals. Bile Duct Neoplasms / chemically induced. Bile Duct Neoplasms / pathology. Cell Enlargement / drug effects. Cell Proliferation / drug effects. Dose-Response Relationship, Drug. Female. Hepatocytes / drug effects. Hepatocytes / pathology. Liver / drug effects. Liver / pathology. Organ Size / drug effects. Rats. Rats, Sprague-Dawley. Thyroid Hormones / blood. Toxicity Tests

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  • (PMID = 16835634.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Thyroid Hormones; DFC2HB4I0K / Polychlorinated Biphenyls; ZRU0C9E32O / 2,4,5,2',4',5'-hexachlorobiphenyl
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42. National Toxicology Program: Toxicology and carcinogenesis studies of dibromoacetic acid (Cas No. 631-64-1) in F344/N rats and B6C3F1 mice (drinking water studies). Natl Toxicol Program Tech Rep Ser; 2007 Apr;(537):1-320
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  • Hematopoietic cell proliferation was noted in females in the 2,000 mg/L group.
  • Small decreases in mean cell hemoglobin and platelet counts occurred in 2,000 mg/L male mice.
  • A positive trend in the incidence of mononuclear cell leukemia occurred in female rats, and the incidence in 1,000 mg/L females was significantly increased.
  • The incidences of mononuclear cell leukemia were increased in 50 and 500 mg/L males.
  • The incidences of multiple hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined) were significantly increased in all exposed groups of males and in 500 and 1,000 mg/L females.
  • The incidences of alveolar/bronchiolar adenoma occurred with positive trends in males and females, and the incidence in 500 mg/L male mice was significantly greater than that in controls.
  • The increased incidences of mononuclear cell leukemia in male rats may have been related to dibromoacetic acid exposure.
  • There was some evidence of carcinogenic activity of dibromoacetic acid in female rats based on an increased incidence and positive trend of mononuclear cell leukemia.
  • [MeSH-minor] Administration, Oral. Animals. Body Weight / drug effects. CHO Cells. Cricetinae. Cricetulus. Drug-Induced Liver Injury / etiology. Drug-Induced Liver Injury / pathology. Female. Kidney Diseases / chemically induced. Kidney Diseases / pathology. Liver / drug effects. Liver / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Lung Neoplasms / chemically induced. Lung Neoplasms / pathology. Male. Mesothelioma / chemically induced. Mesothelioma / secondary. Mice. Mice, Inbred Strains. Micronuclei, Chromosome-Defective / chemically induced. Organ Size / drug effects. Rats. Rats, Inbred F344. Salmonella typhimurium / drug effects. Salmonella typhimurium / genetics. Testis / drug effects. Testis / pathology. Water Supply

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  • (PMID = 17554398.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetates; 0 / Carcinogens; 0 / Environmental Pollutants; 0 / Mutagens; 631-64-1 / dibromoacetic acid
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43. Westermann DH, Rüdiger T, Lohe B, Frohneberg D: [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient]. Urologe A; 2010 Dec;49(12):1527-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Birt-Hogg-Dubé syndrome : bilateral oncocytic kidney tumors in a patient].
  • We report on a rare case of bilateral oncocytic kidney tumors in a patient with Birt-Hogg-Dubé syndrome (BHD).
  • BHD is an autosomal inherited cancer syndrome associated with multiple kidney tumors, benign cutaneous tumors, and pulmonary cysts with spontaneous pneumothorax.
  • [MeSH-major] Birt-Hogg-Dube Syndrome / diagnosis. Birt-Hogg-Dube Syndrome / surgery. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Humans. Kidney Neoplasms / diagnosis. Kidney Neoplasms / surgery. Male. Middle Aged. Syndrome. Treatment Outcome

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  • (PMID = 20949256.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Oncocytoma, renal
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44. Park JM, Choi MG, Kim SW, Chung IS, Yang CW, Kim YS, Jung CK, Lee KY, Kang JH: Increased incidence of colorectal malignancies in renal transplant recipients: a case control study. Am J Transplant; 2010 Sep;10(9):2043-50
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  • [Title] Increased incidence of colorectal malignancies in renal transplant recipients: a case control study.
  • This study was to evaluate the frequency of colorectal neoplasia in renal transplant recipients and to investigate the association with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection.
  • We compared the frequency of colorectal neoplasia among renal transplant recipients with that of the healthy subjects.
  • Of 796 renal transplantation cohorts, 315 were enrolled.
  • Compared with the healthy subjects, the odds ratio (OR) for advanced adenoma was 3.32 (95% CI, 1.81-6.10).
  • EBV positivity was detected in 30.6% of colorectal neoplasia specimens from renal transplant recipients, which was higher than that for the controls (p = 0.002).
  • In conclusion, renal transplant recipients have a significantly increased risk of advanced colorectal neoplasia.
  • EBV was more frequently found in specimens of advanced colorectal neoplasm obtained from the renal transplant recipients.
  • [MeSH-major] Colorectal Neoplasms / epidemiology. Kidney Transplantation / statistics & numerical data. Postoperative Complications / epidemiology
  • [MeSH-minor] Adenoma / epidemiology. Adenoma / physiopathology. Adult. Aged. Case-Control Studies. Cohort Studies. Colonoscopy. Cytomegalovirus / isolation & purification. Disease Progression. Female. Herpesvirus 4, Human / isolation & purification. Humans. Immunohistochemistry. In Situ Hybridization. Incidence. Male. Middle Aged. Odds Ratio. Risk Assessment. Time Factors. Young Adult

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  • [Copyright] © 2010 The Authors Journal compilation © 2010 The American Society of Transplantation and the American Society of Transplant Surgeons.
  • (PMID = 20883538.001).
  • [ISSN] 1600-6143
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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45. Born-Frontsberg E, Quinkler M: [Conn's syndrome]. Internist (Berl); 2009 Jan;50(1):17-26
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  • A suspicious ratio must lead to a confirmatory test to validate the diagnosis of PHA.
  • The aldosterone-producing adenoma (Conn's syndrome) is primarily cured by endoscopical unilateral adrenalectomy.

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  • (PMID = 19099278.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Mineralocorticoid Receptor Antagonists; 27O7W4T232 / Spironolactone
  • [Number-of-references] 27
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46. National Toxicology Program: Toxicology and carcinogenesis studies of methyl isobutyl ketone (Cas No. 108-10-1) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser; 2007 Feb;(538):1-236
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  • In the standard evaluation of the kidney, there were slightly increased incidences of renal tubule adenoma and renal tubule adenoma or carcinoma (combined) in males exposed to 900 or 1,800 ppm, and renal tubule carcinoma in males exposed to 1,800 ppm.
  • The incidences of renal tubule hyperplasia were also significantly increased in the 450 and 1,800 ppm males, and the severities were greater than in the chamber controls.
  • The incidences of transitional epithelial hyperplasia of the renal pelvis in males exposed to 900 or 1,800 ppm and mineralization of the renal papilla in all groups of exposed males were significantly increased.
  • In addition, two female rats exposed to 1,800 ppm had renal mesenchymal tumors.
  • In the extended evaluation of the kidney, renal tubule adenomas and renal tubule hyperplasia occurred in all groups of exposed male rats.
  • In the combined single and step section analysis, the incidences of renal tubule adenoma and renal tubule adenoma or carcinoma (combined) were significantly increased in males exposed to 1,800 ppm.
  • The incidences of renal tubule hyperplasia were also significantly increased in all exposed groups of males.
  • There was a positive trend in the incidences of mononuclear cell leukemia in males, and the incidence in the 1,800 ppm group was significantly increased.
  • The incidences of hepatocellular adenoma and hepatocellular adenoma or carcinoma (combined) were significantly increased in males and females exposed to 1,800 ppm.
  • CONCLUSIONS: Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of methyl isobutyl ketone in male F344/N rats based on increased incidences of renal tubule neoplasms.
  • Increased incidences of mononuclear cell leukemia in 1,800 ppm male F344/N rats may have been related to methyl isobutyl ketone exposure.
  • There was equivocal evidence of carcinogenic activity of methyl isobutyl ketone in female F344/N rats based on the occurrence of renal mesenchymal tumors in the 1,800 ppm group.
  • Exposure to methyl isobutyl ketone resulted in nonneoplastic lesions of the kidney characteristic of alpha2u-globulin accumulation in male rats and nephropathy in female rats.
  • [MeSH-minor] Administration, Oral. Adrenal Glands / drug effects. Animals. Body Weight / drug effects. Female. Kidney / drug effects. Kidney / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia, Myeloid / chemically induced. Leukemia, Myeloid / pathology. Liver / drug effects. Liver / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Lung Neoplasms / chemically induced. Lung Neoplasms / pathology. Male. Mice. Mice, Inbred Strains. Occupational Exposure. Rats. Rats, Inbred F344. Water Supply

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  • (PMID = 17557116.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Environmental Pollutants; 0 / Solvents; 6QDY60NH6N / Methyl n-Butyl Ketone; U5T7B88CNP / methyl isobutyl ketone
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47. Buurman H, Saeger W: Abnormalities in incidentally removed adrenal glands. Endocr Pathol; 2006;17(3):277-82
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  • The incidence and type of pathological findings in a large group of surgically removed adrenal glands were analyzed: 282 resected adrenals from the years 1995 to 2004 were examined; 242 adrenals were removed for therapy of renal cell carcinomas (in one case both adrenals were removed).
  • Other indications for adrenalectomies were malignant tumors (urothelial carcinoma, squamous cell carcinoma, sarcoma, lymphoma, etc.) and benign findings (oncocytoma, angiomyolipoma, pyelonephritis, etc.).
  • A total of 18 adrenals exhibited a metastasis or diffuse infiltration of the adrenal or para-adrenal tissue by a malignant tumor (17 renal cell carcinomas, 1 non-Hodgkin's lymphoma).
  • Seven adrenals exhibited an adenoma.
  • The adrenals exhibited infiltration or metastasis by malignant tumors (6.4%), adrenal adenomas (2.5%), adrenal hyperplasias (31.6%), and other alterations (38.7%).
  • [MeSH-minor] Adrenalectomy. Adult. Aged. Aged, 80 and over. Carcinoma, Renal Cell / surgery. Female. Humans. Kidney Neoplasms / surgery. Male. Middle Aged

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  • (PMID = 17308364.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Cheng L, Zhang S, MacLennan GT, Lopez-Beltran A, Montironi R: Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms. Hum Pathol; 2009 Jan;40(1):10-29
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  • [Title] Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms.
  • Renal cell carcinomas comprise a heterogeneous group of epithelial neoplasms with diverse biologic potential and variable clinical outcomes.
  • The application of molecular and cytogenetic techniques to the study of renal neoplasms has improved our understanding of the molecular mechanisms responsible for tumor initiation and progression.
  • Molecular classification of renal cell carcinomas has also provided new avenues for diagnosis, clinical outcome, and therapy response prediction.
  • In this article, we review the molecular markers for various renal epithelial neoplasms and discuss the mechanisms underlying the development of these neoplasms.
  • We also evaluate the use of molecular and cytogenetic techniques in establishing an accurate diagnosis in difficult cases and their potential usefulness in accurately classifying renal neoplasms, assessing prognosis, and selecting appropriate therapy.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Gene Expression Profiling. Kidney Neoplasms / genetics. Molecular Biology. Neoplasms, Glandular and Epithelial / genetics
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / genetics. Adenocarcinoma, Clear Cell / pathology. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Diagnosis, Differential. Humans. Prognosis

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  • (PMID = 19027455.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 182
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49. Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 8 expression in salivary gland tumors. Head Neck Pathol; 2008 Sep;2(3):169-74
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  • The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum.
  • The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Kallikreins / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Glands, Minor / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Humans. Immunoenzyme Techniques

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  • (PMID = 20614312.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK8 protein, human; EC 3.4.21.- / Kallikreins
  • [Other-IDs] NLM/ PMC2807567
  • [Keywords] NOTNLM ; Human kallikrein 8 / Immunohistochemistry / Kallikreins / Prognostic markers / Salivary gland tumors
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50. Grebe SO, Borrmann M, Altenburg A, Wesselman U, Hein D, Haage P: Chronic inflammation and accelerated atherosclerosis as important cofactors in nephrogenic systemic fibrosis following intravenous gadolinium exposure. Clin Exp Nephrol; 2008 Oct;12(5):403-6
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  • Nephrogenic systemic fibrosis (NSF) is a rare disorder in patients with chronic kidney disease characterized by an increased tissue deposition of collagen.
  • Prior studies indirectly suggested a possible impact of chronic inflammation and accelerated atherosclerosis--a common feature in kidney diseased patients--whereas recent data focused almost exclusively on gadolinium (Gd)-based MR contrast agents.
  • A 52-year-old Caucasian woman with end-stage renal disease was admitted to our hospital with progressive muscle weakness and skin induration resulting in growing immobility.
  • Her past medical history revealed a secondary HPT, multiple vascular complications, a seronegative rheumatoid arthritis, and a pituitary gland adenoma.
  • [MeSH-major] Atherosclerosis / complications. Contrast Media / adverse effects. Gadolinium / adverse effects. Inflammation / complications. Kidney Diseases / chemically induced. Kidney Diseases / etiology


51. Torabinezad S, Kumar PV, Hashemi SB, Rahimi A: Osteoclastomalike giant cell tumor of the parotid gland: report of a case with fine needle aspiration diagnosis. Acta Cytol; 2006 Jan-Feb;50(1):80-3
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  • [Title] Osteoclastomalike giant cell tumor of the parotid gland: report of a case with fine needle aspiration diagnosis.
  • BACKGROUND: Osteoclastomalike giant cell tumor of the parotid gland has been reported rarely.
  • The tumor has occurred rarely at many sites, such as thyroid, pancreas, soft tissue, breast, skin, heart, colon, lung, kidney, ovary and bladder.
  • CASE: A 35-year-old female presented with a mass in the left parotid gland clinically diagnosed as a pleomorphic adenoma.
  • The smears were diagnosed as positive for malignancy, suggestive of osteoclastomalike giant cell tumor.
  • The tumor was excised, and histopathologic study confirmed the cytologic diagnosis.
  • CONCLUSION: The cytologic findings of osteoclastomalike giant cell tumor of the parotid gland have not been previously reported.
  • FNA aided the diagnosis and planning of treatment.
  • FNA is important in the diagnosis of parotid tumors.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Parotid Gland / pathology. Parotid Neoplasms / diagnosis

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  • (PMID = 16514845.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies). Natl Toxicol Program Tech Rep Ser; 2010 Sep;(560):1, 7-31,33-171 passim
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  • The incidences of mononuclear cell leukemia were significantly increased in 20 and 50 mg/kg females and significantly decreased in 20 and 50 mg/kg males.
  • Incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined) were significantly increased in 20 mg/kg males.
  • The incidence of testicular interstitial cell adenoma (including bilateral) was significantly decreased in 50 mg/kg males.
  • In the liver of males, the incidences of basophilic focus in all dosed groups, the incidence of clear cell focus in the 20 mg/kg group, and the incidence of eosinophilic focus in the 50 mg/kg group were significantly increased.
  • The incidences of hepatocellular adenoma in males and females were significantly increased in the 50 mg/kg groups.
  • Incidences of hepatocellular adenoma or carcinoma (combined) in males and females were significantly increased in the 50 mg/kg groups.
  • Incidences of multiple hepatocellular adenomas and carcinomas were significantly increased in 10 and 50 mg/kg males, and there was an increased incidence of multiple hepatocellular adenomas in 50 mg/kg females.
  • The incidence of eosinophilic focus was significantly increased in 50 mg/kg males, and the incidences of mixed cell focus and cytoplasmic vacuolization were significantly increased in 50 mg/kg females.
  • There was a marginally increased incidence of pancreatic islet adenoma in 50 mg/kg males and in 10 and 50 mg/kg females, with an earlier day of first incidence in males.
  • The incidence of glomerular metaplasia of the kidney was significantly increased in 50 mg/kg females, and the incidences of cytoplasmic alteration of the submandibular salivary gland were significantly increased in all dosed female groups.
  • The increased incidences of cytoplasmic alteration of the submandibular salivary gland and glomerular metaplasia of the kidney in female mice indicated a masculinizing effect from androstenedione treatment.
  • CONCLUSIONS: under the conditions of these 2-year gavage studies, there was equivocal evidence of carcinogenic activity of androstenedione in male F344/N rats based on increased incidences of alveolar/bronchiolar adenoma and alveolar/bronchiolar adenoma or carcinoma (combined).
  • There was equivocal evidence of carcinogenic activity of androstenedione in female F344/N rats based on increased incidences of mononuclear cell leukemia.
  • There was clear evidence of carcinogenic activity of androstenedione in male B6C3F1 mice based on increased incidences of multiple hepatocellular adenoma and hepatocellular carcinoma and increased incidence of hepatoblastoma.
  • There was clear evidence of carcinogenic activity of androstenedione in female B6C3F1 mice based on increased incidences of hepatocellular adenoma and hepatocellular carcinoma.
  • Increased incidences of pancreatic islet adenoma in male and female mice were also considered chemical related.
  • Androstenedione administration caused increased incidences in nonneoplastic lesions of the liver in male and female rats and mice; pancreatic islets and exocrine pancreas of female rats; and clitoral gland, kidney, and submandibular salivary gland of female mice.
  • Decreases in the incidences of testicular interstitial cell adenoma in male rats, mammary gland fibroadenoma, cysts, and hyperplasia in female rats, and malignant lymphoma in female mice were considered related to androstenedione administration.

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  • (PMID = 21037592.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Review; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Mutagens; 409J2J96VR / Androstenedione
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53. Argüelles Salido E, Marcilla Plaza D, Medina López R, Congregado Ruiz B, Campoy Martínez P, Cayuela Domínguez A: [Renal oncocytoma. Review of our 22 patients]. Actas Urol Esp; 2006 Jun;30(6):583-90
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  • [Title] [Renal oncocytoma. Review of our 22 patients].
  • [Transliterated title] Oncocitoma renal. Revisión de nuestra serie de 22 pacientes.
  • Renal oncocytoma (OR) is a benign tumor.
  • It may represent up to 3-7% of solid kidney masses, and shows specifics cellular and evolutive characteristics.
  • MATERIALS AND METHODS: Between 1986 and 2005, 478 kidney tumors have been surgically treated at our institution.
  • We report the frequency and characteristics of OR in our patients, compared with renal cell carcinomas (RCC).
  • 12 in the left kidney and 12 in the right one, one patient presenting oncocytomatosis.
  • CONCLUSIONS: The rate of OR found in our sample population of renal tumors undergoing surgery matches other series already published.
  • All cases presented a benign evolution.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • (PMID = 16921835.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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54. Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser; 2006 Feb;(533):1-264
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  • There was a positive trend in the incidences of renal tubule adenoma in males, and the incidences in 625 and 1,250 ppm males exceeded the historical control range for all routes; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia.
  • Due to these findings, additional kidney sections were evaluated; results indicated additional renal tubule adenomas in all groups of males and renal tubule hyperplasia in all groups of males and females.
  • Increased incidences of mononuclear cell leukemia in all exposed groups of females exceeded the historical control range from feed studies, and the incidence in 625 ppm females was significantly greater than that in the controls.
  • Male rats exposed to 312 or 625 ppm had significantly increased incidences of mononuclear cell leukemia.
  • In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups, and these incidences exceeded the historical control range.
  • In female mice, the incidences of hepatocellular adenoma in the 625 and 1,250 ppm groups were higher than expected after adjusting for the lower body weights in these groups.
  • The incidences of kidney nephropathy and mineralization in exposed groups of females and the severity of nephropathy in exposed groups of males were significantly increased.
  • CONCLUSIONS: Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma; mononuclear cell leukemia in male F344/N rats may have been related to benzophenone exposure.
  • There was equivocal evidence of carcinogenic activity of benzophenone in female F344/N rats based on the marginally increased incidences of mononuclear cell leukemia and histiocytic sarcoma.
  • There was some evidence of carcinogenic activity of benzophenone in male B6C3F1 mice based on increased incidences of hepatocellular neoplasms, primarily adenoma.
  • There was some evidence of carcinogenic activity of benzophenone in female B6C3F1 mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F1 mice may have been related to benzophenone exposure.
  • Administration of benzophenone in feed resulted in increased incidences and/or severities of nonneoplastic lesions in the kidney and liver of male and female rats and in the liver, kidney, nose, and spleen of male and female mice.
  • [MeSH-minor] Animals. Body Weight / drug effects. Carcinogenicity Tests. Dose-Response Relationship, Drug. Female. Histiocytic Disorders, Malignant / chemically induced. Histiocytic Disorders, Malignant / pathology. Kidney Neoplasms / chemically induced. Kidney Neoplasms / pathology. Leukemia / chemically induced. Leukemia / pathology. Liver Neoplasms / chemically induced. Liver Neoplasms / pathology. Longevity / drug effects. Male. Mice. Mice, Inbred C57BL. Mutagenicity Tests. Rats. Rats, Inbred F344. Sarcoma / chemically induced. Sarcoma / pathology. Toxicity Tests, Chronic

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  • (PMID = 16741556.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzophenones; 0 / Photosensitizing Agents; 701M4TTV9O / benzophenone
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55. Petersson F, Gatalica Z, Grossmann P, Perez Montiel MD, Alvarado Cabrero I, Bulimbasic S, Swatek A, Straka L, Tichy T, Hora M, Kuroda N, Legendre B, Michal M, Hes O: Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases. Virchows Arch; 2010 Apr;456(4):355-65
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  • [Title] Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases.
  • Hybrid oncocytic/chromophobe tumors (HOCT) of the kidney have been described in patients with Birt-Hogg-Dubé syndrome (BHD) and in association with renal oncocytosis without BHD.
  • HOCT in patients without evidence of BHD or renal oncocytosis is exceedingly rare, and these cases have been poorly characterized.
  • We have identified and studied 14 cases of HOCT from previously diagnosed renal oncocytomas (398 cases) and chromophobe renal cell carcinomas (351 cases) without evidence of BHD or renal oncocytosis.
  • No pathogenic mutations were found in the VHL, c-kit, PDGFR, and folliculin (FLCN) genes. (1) We have shown that hybrid oncocytic/chromophobe tumors of the kidney do occur, albeit rarely, outside the Birt-Hogg-Dubé syndrome and without associated renal oncocytosis. (2) These tumors constitute a relatively homogenous group with histomorphologic features of both chromophobe renal cell carcinoma and renal oncocytoma. (3) Sporadic hybrid oncocytic/chromophobe renal tumors are characterized by multiple numerical aberrations (both mono- and polysomies) of chromosomes 1, 2, 6, 9, 10, 13, 17, 21, and 22 and lack of mutations in the VHL, c-kit, PDGFRA, and FLCN genes. (4) The tumors seem to behave indolently as no evidence of malignant behavior was documented in our series, although admittedly, the follow-up was too short to fully elucidate the biological nature of this rare neoplasm.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / genetics. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Chromosome Aberrations. Cytogenetic Analysis. Female. Humans. Kidney / metabolism. Kidney / pathology. Kidney / ultrastructure. Loss of Heterozygosity / genetics. Male. Middle Aged. Mutation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism. Receptor, Platelet-Derived Growth Factor alpha / genetics. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism. Von Hippel-Lindau Tumor Suppressor Protein / genetics. Von Hippel-Lindau Tumor Suppressor Protein / metabolism

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  • (PMID = 20300772.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins; EC 2.3.2.27 / Von Hippel-Lindau Tumor Suppressor Protein; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 6.3.2.- / VHL protein, human
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56. Kumar S, Mandal AK, Acharya NR, Kakkad N, Singh SK: Laparoscopic nephron-sparing surgery for metanephric adenoma. Surg Laparosc Endosc Percutan Tech; 2007 Dec;17(6):573-5
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  • [Title] Laparoscopic nephron-sparing surgery for metanephric adenoma.
  • Histologic examination of the mass was consistent with metanephric adenoma.
  • We are reporting this case of metanephric adenoma, being treated with laparoscopic partial nephrectomy.
  • [MeSH-major] Adenoma / surgery. Kidney Neoplasms / surgery. Laparoscopy / methods. Nephrectomy / methods

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  • (PMID = 18097330.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Chen VH, Mayes JM, Madden JF, Stein AJ, Mouraviev V, Polascik TJ: The effect of cryoablation on the histologic interpretation of intraoperative biopsy of small clear cell renal carcinoma and renal oncocytoma. J Endourol; 2008 Aug;22(8):1617-21
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  • [Title] The effect of cryoablation on the histologic interpretation of intraoperative biopsy of small clear cell renal carcinoma and renal oncocytoma.
  • BACKGROUND AND PURPOSE: We evaluated the effects of the first freeze-thaw cycle of cryoablation on Fuhrman grade, histology, and tumor architecture of small clear cell renal carcinomas and renal oncocytomas using an 18-gauge needle biopsy.
  • PATIENTS AND METHODS: Between August 2006 and June 2007, 11 patients underwent cryoablation for 14 renal neoplasms.
  • A tissue diagnosis was rendered in 100% of 11 patients.
  • Pathologic diagnosis following the first freeze-thaw cycle of cryotherapy, as compared with the pretreatment biopsy, was accurate in 10 (91%) cases.
  • Neither of the two post-first freeze biopsies in the remaining patient rendered a diagnosis: one had an insufficient quantity of tissue and the second missed the tumor, abstracting benign renal tissue.


58. Osunkoya AO, Cohen C, Lawson D, Picken MM, Amin MB, Young AN: Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. Hum Pathol; 2009 Feb;40(2):206-10
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  • [Title] Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
  • In a recent oligonucleotide microarray study, we identified claudin-7 and claudin-8 as candidate markers to distinguish chromophobe renal cell carcinoma from other renal tumors, including oncocytoma.
  • Distinction of these lesions can be difficult by light microscopy but is clinically important because chromophobe renal cell carcinoma has malignant biological potential, whereas renal oncocytoma is benign.
  • Claudin-7 and claudin-8 expression was studied by immunohistochemistry in 11 chromophobe renal cell carcinomas and 17 oncocytomas using formalin-fixed paraffin-embedded tissue sections of tumor with adjacent nonneoplastic kidney.
  • Specificity was verified by negative control reactions without primary antibody and appropriate membranous staining patterns in positive control tissues (colon carcinoma and adjacent nonneoplastic kidney).
  • Claudin-7 protein was expressed in a membranous pattern in 10 of 11 chromophobe renal cell carcinomas and 4 of 17 oncocytomas (P < .01).
  • In chromophobe renal cell carcinoma, 0 of 11 cases showed cytoplasmic, 3 of 11 membranous, and 8 of 11 negative reactions (P < .01).
  • The immunohistochemical pattern of membranous claudin-7 and negative claudin-8 was seen in 7 of 11 chromophobe renal cell carcinomas and 1 of 17 oncocytomas (63% sensitivity, 84% specificity, 88% positive predictive value for chromophobe renal cell carcinoma).
  • Negative claudin-7 and cytoplasmic claudin-8 were observed in 10 of 17 oncocytomas and 0 of 11 chromophobe renal cell carcinomas (59% sensitivity, 100% specificity and positive predictive value for oncocytoma).
  • The distal nephron proteins claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma.
  • Expression of claudin-7 and claudin-8 may reflect the relationship of chromophobe renal cell carcinoma and oncocytoma to intercalated cells of the cortical collecting duct.
  • [MeSH-major] Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Claudins. Diagnosis, Differential. Humans. Immunohistochemistry. Sensitivity and Specificity


59. Wang MH, Lee W, Luo YL, Weis MT, Yao HP: Altered expression of the RON receptor tyrosine kinase in various epithelial cancers and its contribution to tumourigenic phenotypes in thyroid cancer cells. J Pathol; 2007 Dec;213(4):402-11
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  • RON was almost exclusively expressed at variable levels in normal epithelial cells from the digestive track, lung, kidney, pancreas, liver, breast, bladder, skin, and others.
  • In contrast, limited RON overexpression was observed in cancers from stomach, kidney, brain, liver, ovary, and prostate.
  • Detailed analysis of thyroid tissues showed that RON was hardly detected in normal thyroid cells, moderately expressed in adenoma samples, but overexpressed in about half of papillary and follicular cancer specimens.
  • Activation of RON increased cell growth and migration via the MAP kinase and AKT pathways.
  • Silencing RON expression significantly prevented cell growth and increased cell apoptotic death.
  • [MeSH-minor] Antibodies, Monoclonal / immunology. Apoptosis. Cell Division. Cell Transformation, Neoplastic. Disease Progression. Epithelial Cells / metabolism. Female. Gene Expression Regulation, Neoplastic. Gene Silencing. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Neoplasms / metabolism. Tissue Array Analysis / methods. Tumor Cells, Cultured

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  • [Copyright] (c) 2007 Pathological Society of Great Britain and Ireland
  • (PMID = 17955509.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA91980
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Neoplasm Proteins; EC 2.7.1.- / RON protein; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases
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60. Petrolla AA, MacLennan GT: Renal cell carcinoma and other concurrent renal neoplasms. J Urol; 2007 Nov;178(5):2163
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal cell carcinoma and other concurrent renal neoplasms.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Angiomyolipoma / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Nephrectomy. Prognosis

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  • (PMID = 17870118.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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61. Rosenkrantz AB, Hindman N, Fitzgerald EF, Niver BE, Melamed J, Babb JS: MRI features of renal oncocytoma and chromophobe renal cell carcinoma. AJR Am J Roentgenol; 2010 Dec;195(6):W421-7
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  • [Title] MRI features of renal oncocytoma and chromophobe renal cell carcinoma.
  • OBJECTIVE: The purpose of this study was to retrospectively describe the MRI features of the pathologically related entities renal oncocytoma and chromophobe renal cell carcinoma (RCC).
  • MATERIALS AND METHODS: Twenty-eight cases of histologically proven renal oncocytoma and 15 of chromophobe RCC evaluated with preoperative MRI from January 2003 through June 2009 at our institution were independently reviewed for an array of MRI features by two radiologists blinded to the final histopathologic diagnosis.
  • These features were tabulated and compared between chromophobe RCC and renal oncocytoma by use of the Mann-Whitney test and binary logistic regression.
  • RESULTS: Renal oncocytoma and chromophobe RCC showed no significant difference in size or any of 16 qualitative imaging features (p = 0.0842-1.0, reader 1; p = 0.0611-1.0, reader 2).
  • Microscopic fat, hemorrhage, cysts, infiltrative margins, perinephric fat invasion, renal vein invasion, enhancement homogeneity, and hypervascularity were each observed in less than 20% of cases by both readers.
  • A central scar and segmental enhancement inversion (a recently described finding in which early contrast-enhanced images show relatively more enhanced and less enhanced intralesional components with inversion of their relative enhancement on later images) were observed by both readers in at least 10% of cases of both renal oncocytoma and of chromophobe RCC with no significant difference between the two entities (p = 0.2092-0.2960).
  • CONCLUSION: We have presented the largest series to date of the MRI features of both renal oncocytoma and chromophobe RCC.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Magnetic Resonance Imaging / methods


62. Lerut E, Roskams T, Joniau S, Oyen R, Achten R, Van Poppel H, Debiec-Rychter M: Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics. Hum Pathol; 2006 Sep;37(9):1227-32
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  • [Title] Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics.
  • Metanephric adenoma is a rare benign tumor of the kidney.
  • It is considered to be derived from embryonic renal tissue and to be the benign counterpart of the Wilms tumor.
  • At renal ultrasonography and magnetic resonance imaging, a hemorrhagic tumor of 10 cm in diameter originating from the right kidney was seen.
  • Based on the imaging findings, the diagnosis of a cystic renal cell carcinoma with recent hemorrhage was suggested, and a radical nephrectomy was performed.
  • Pathologic examination concluded to a metanephric adenoma.
  • To our knowledge, this is the first report on these chromosomal abnormalities in metanephric adenoma.
  • [MeSH-major] Adenoma / genetics. Adenoma / pathology. Kidney Neoplasms / genetics. Kidney Neoplasms / pathology. Pregnancy Complications / genetics. Pregnancy Complications / pathology
  • [MeSH-minor] Adult. Carcinoma, Renal Cell / pathology. Chromosome Aberrations. Diagnosis, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Kidney / embryology. Kidney / pathology. Magnetic Resonance Imaging. Nephrectomy. Pregnancy. Ultrasonography. Wilms Tumor / pathology


63. Picken MM: Editorial comment from Dr Picken to Molecular pathology of renal oncocytoma: a review. Int J Urol; 2010 Jul;17(7):613-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Editorial comment from Dr Picken to Molecular pathology of renal oncocytoma: a review.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • [CommentOn] Int J Urol. 2010 Jul;17(7):602-12 [20590944.001]
  • (PMID = 20590946.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Australia
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64. Kahveci A, Ari E, Arikan H, Koc M, Tuglular S, Ozener C: Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient. Hemodial Int; 2010 Jan;14(1):91-3
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  • [Title] Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient.
  • Abstract We report the case of a 54-year-old hemodialysis patient who presented with recurrent fever due to Streptococcus bovis bacteremia related to colonic tubulovillous adenoma.
  • In this paper, we discussed the relation between S. bovis bacteremia, colonic adenomas, and hemodialysis.
  • Awareness of this association is critical for early diagnosis and management.
  • [MeSH-major] Adenoma / microbiology. Bacteremia / etiology. Colonic Neoplasms / microbiology. Kidney Failure, Chronic / therapy. Renal Dialysis / adverse effects. Streptococcal Infections / pathology. Streptococcus bovis / isolation & purification

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  • (PMID = 19758303.001).
  • [ISSN] 1542-4758
  • [Journal-full-title] Hemodialysis international. International Symposium on Home Hemodialysis
  • [ISO-abbreviation] Hemodial Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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65. Rogers CG, Singh A, Blatt AM, Linehan WM, Pinto PA: Robotic partial nephrectomy for complex renal tumors: surgical technique. Eur Urol; 2008 Mar;53(3):514-21
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  • [Title] Robotic partial nephrectomy for complex renal tumors: surgical technique.
  • OBJECTIVES: Laparoscopic partial nephrectomy requires advanced training to accomplish tumor resection and renal reconstruction while minimizing warm ischemia times.
  • Complex renal tumors add an additional challenge to a minimally invasive approach to nephron-sparing surgery.
  • We describe our technique, illustrated with video, of robotic partial nephrectomy for complex renal tumors, including hilar, endophytic, and multiple tumors.
  • Three patients had hereditary kidney cancer.
  • Histopathology confirmed clear-cell renal cell carcinoma (n=3), hybrid oncocytic tumor (n=2), chromophobe renal cell carcinoma (n=2), and oncocytoma (n=1).
  • CONCLUSIONS: Robotic partial nephrectomy is safe and feasible for select patients with complex renal tumors, including hilar, endophytic, and multiple tumors.
  • Robotic assistance may facilitate a minimally invasive, nephron-sparing approach for select patients with complex renal tumors who might otherwise require open surgery or total nephrectomy.
  • [MeSH-major] Kidney Neoplasms / surgery. Nephrectomy / methods. Robotics / instrumentation
  • [MeSH-minor] Adenocarcinoma, Clear Cell / diagnosis. Adenocarcinoma, Clear Cell / surgery. Adenoma, Oxyphilic / diagnosis. Adenoma, Oxyphilic / surgery. Adult. Aged. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / surgery. Equipment Design. Female. Follow-Up Studies. Humans. Length of Stay. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Video Recording

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  • [Cites] J Endourol. 2005 May;19(4):441-5; discussion 445 [15910252.001]
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  • (PMID = 17961910.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 SC006659-25
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ NIHMS65236; NLM/ PMC2644902
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66. Zhou M, Zhu Y, Wang L, Wang Y, Fu S, Min Z: Urological malignancy as a complication of renal transplantation: a report of twelve clinical cases. Clin Transpl; 2006;:395-8
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  • [Title] Urological malignancy as a complication of renal transplantation: a report of twelve clinical cases.
  • OBJECTIVE: To analyze the epidemiographic features of urological malignancy in renal allograft recipients (RAR) in a single center METHODS: A retrospective analysis was made on 3150 patients who received renal allografts from June 1978 until the autumn of 2006 and anti-rejection treatment for at least 3 months.
  • RESULTS: Of the 3150 recipients, 33 (1.05%) developed malignancies, including 12 patients (0.38%; eight males and four females) with urological tumors and 21 patients with skin carcinoma, right liver lobular cystic adenocarcinoma, hepatocellular carcinoma, gastric cancer, colorectal carcinoma, ileocecal adenoma, lip cancer, nasopharyngeal carcinoma, Kaposi's Sarcoma, pulmonary lymphoma, and breast cancer.
  • The 12 cases of urological malignancies included one case of renal cell carcinoma, one case of transplanted kidney carcinoma, two cases of bilateral pelvic transitional cell carcinoma (TCC), three cases of unilateral pelvic TCC, one case of bilateral ureter TCC, one case of unilateral ureter TCC, and three cases of bladder TCC.
  • The age at which the diagnosis was made ranged from 48 to 66 years with a mean of 58.3 +/- 4.6 years, and the mean course of immunosuppressive therapy ranged from 26 to 120 months with a mean of 62 +/- 18 months.
  • One of the 12 patients died soon after the diagnosis was made, and the remaining 11 patients received surgical resection.
  • CONCLUSION: Urological malignancies, especially TCC, are an important complication in renal transplanatation found in this center.
  • The incidence of urological malignancy in renal allograft recipients (RAR) is about 10 times that found in the general population of Shanghai versus two times for other malignancies.
  • The immunological status of patients after renal transplantation should be assessed regularly.
  • Treatment includes early diagnosis, timely surgical resection, and reduction of immunosuppressive agents.
  • [MeSH-major] Kidney Transplantation / adverse effects. Urologic Neoplasms / epidemiology

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  • (PMID = 18365395.001).
  • [ISSN] 0890-9016
  • [Journal-full-title] Clinical transplants
  • [ISO-abbreviation] Clin Transpl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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67. Ahmad S, Jielani AA, Khan K, Fatima T, Zia N, ud Duha M, Samad A, Memon K: Dual phase MIBI scintigraphy in diagnosis of parathyroid adenoma followed by ultrasound guided percutaneous alcoholic ablation. J Ayub Med Coll Abbottabad; 2008 Jul-Sep;20(3):149-51
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  • [Title] Dual phase MIBI scintigraphy in diagnosis of parathyroid adenoma followed by ultrasound guided percutaneous alcoholic ablation.
  • Primary HPT is caused by parathyroid adenoma in 80-85% of patients.
  • Clinical manifestations are kidney stones, abdominal groans, painful bones, psychic moans, and fatigue overtones.
  • Ultrasonography is widely used in suspected cases for localization of parathyroid adenoma.
  • Dual phase Tc-99m MIBI scinitigraphy for detection of parathyroid adenomas has sensitivity and specificity values ranging from 82% to 100% and from 89% to 100%, respectively.
  • [MeSH-major] Adenoma / radionuclide imaging. Adenoma / therapy. Catheter Ablation / methods. Ethanol / therapeutic use. Parathyroid Neoplasms / radionuclide imaging. Parathyroid Neoplasms / therapy

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  • (PMID = 19610543.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 3K9958V90M / Ethanol; 971Z4W1S09 / Technetium Tc 99m Sestamibi
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68. Thomas AA, Rackley RR, Lee U, Goldman HB, Vasavada SP, Hansel DE: Urethral diverticula in 90 female patients: a study with emphasis on neoplastic alterations. J Urol; 2008 Dec;180(6):2463-7
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  • Neoplastic alterations identified in 5 patients (6%) were glandular in nature, including 1 clear cell and 4 invasive adenocarcinomas.
  • Superficial changes associated with invasive carcinoma included villous adenoma in 1 case, intestinal metaplasia in 2 and high grade dysplasia in 3.
  • Of the 90 patients the remaining 82 demonstrated benign findings, including nephrogenic adenoma in 10 (11%).
  • CONCLUSIONS: Although most cases of surgically resected diverticula demonstrate benign features, approximately 10% show atypical glandular findings, including invasive adenocarcinoma.
  • [MeSH-major] Diverticulum / complications. Diverticulum / pathology. Urethral Diseases / complications. Urethral Diseases / pathology. Urethral Neoplasms / diagnosis. Urethral Neoplasms / pathology

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  • (PMID = 18930487.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Xiao L, Lu XY, Zhu XZ, Jones TD, Cheng L: Metastasising pleomorphic adenoma of the parotid presenting as a solitary kidney mass. Pathology; 2008 Jan;40(1):87-9
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  • [Title] Metastasising pleomorphic adenoma of the parotid presenting as a solitary kidney mass.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Kidney Neoplasms / diagnosis. Parotid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Kidney / pathology

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  • (PMID = 18038324.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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70. Matusan K, Dordevic G, Mozetic V, Lucin K: Expression of osteopontin and CD44 molecule in papillary renal cell tumors. Pathol Oncol Res; 2005;11(2):108-13
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  • [Title] Expression of osteopontin and CD44 molecule in papillary renal cell tumors.
  • The aim of the study was to analyze the expression of CD44 adhesion molecule and its ligand osteopontin in papillary renal cell tumors, and to assess the possible prognostic significance of CD44 and osteopontin expression in papillary renal cell carcinomas.
  • The expression of the standard and v6 exon containing isoforms of CD44 molecule, as well as of its ligand osteopontin, was immunohistochemically evaluated in 43 papillary renal cell tumors, which included 5 adenomas and 38 carcinomas.
  • In order to assess their prognostic significance, the results obtained in papillary renal cell carcinomas were compared to usual clinicopathological parameters such as tumor size, histological grade, pathological stage, and Ki-67 proliferation index.
  • Normal renal tissue was negative for CD44s and v6 isoforms, while the expression of osteopontin was found in distal tubular epithelial cells in the form of cytoplasmic granular positivity.
  • Papillary renal cell adenomas were generally negative for CD44s, except for focal positivity found in one sample.
  • The osteopontin protein was detected in all adenomas and all papillary renal cell carcinomas, except one.
  • Our results show constitutive expression of osteopontin in papillary renal tumors, including papillary renal cell adenomas.
  • The upregulation of CD44s and v6 isoforms, although found in a considerable number of papillary renal cell carcinomas, does not appear to have any prognostic value in this type of renal cancer.
  • [MeSH-major] Antigens, CD44 / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Papillary / metabolism. Carcinoma, Renal Cell / metabolism. Kidney Neoplasms / metabolism. Sialoglycoproteins / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Female. Humans. Kidney / metabolism. Kidney / pathology. Male. Neoplasm Staging. Osteopontin

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  • (PMID = 15999156.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / SPP1 protein, human; 0 / Sialoglycoproteins; 106441-73-0 / Osteopontin
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71. Amin W, Parwani AV: Nephrogenic adenoma. Pathol Res Pract; 2010 Oct 15;206(10):659-62
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  • [Title] Nephrogenic adenoma.
  • Nephrogenic adenoma is an uncommon benign lesion.
  • The proposal that nephrogenic adenoma originates from the implantation of exfoliated renal tubular cells is lately gaining wider acceptance.
  • The role of immunohistochemistry cannot be undermined in the diagnosis of nephrogenic adenoma, although histological diagnosis is usually conclusive.
  • The possibility of nephrogenic adenoma should always be in the differential diagnosis when evaluating patients with predisposed urinary tract symptoms.
  • [MeSH-major] Adenoma / pathology. Kidney Tubules / pathology. Urologic Neoplasms / pathology
  • [MeSH-minor] Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Humans. Immunohistochemistry. Predictive Value of Tests. Recurrence. Treatment Outcome. Urine / cytology

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  • [Copyright] Copyright © 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20619548.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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72. Volmar KE, Cummings TJ, Wang WH, Creager AJ, Tyler DS, Xie HB: Clear cell hidradenoma: a mimic of metastatic clear cell tumors. Arch Pathol Lab Med; 2005 May;129(5):e113-6
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  • [Title] Clear cell hidradenoma: a mimic of metastatic clear cell tumors.
  • Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventional-type renal cell carcinoma.
  • Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma.
  • Detailed clinical history, physical findings, and ancillary studies are essential for correct diagnosis and categorization of these tumors.
  • We report the rare case of a patient with renal cell carcinoma who underwent excision of an axillary clear cell hidradenoma, which was clinically suggestive of cutaneous metastatic disease.
  • [MeSH-major] Adenoma, Sweat Gland / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Axilla. Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Lymph Nodes / pathology. Lymph Nodes / surgery. Male. Middle Aged. Mitotic Index. Neoplasm Metastasis / diagnosis. Treatment Outcome

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  • (PMID = 15859654.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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73. Chen G, Mou LP, Yao J, You TT, Shen XY, Zhu XQ, Qiao YF, Lin M, Fang XW, Zou X, Lin LX: [Construction of GSK-3beta-targeting RNAi adenovirus vector and the influence of Wnt/beta-catenin pathway in proliferation of human thyrocytes]. Zhonghua Yi Xue Za Zhi; 2008 Nov 4;88(40):2821-5
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  • METHODS: An adenovirus plasmid that contained the RNAi cassette targeting the GSK-3beta gene was constructed by homologous recombination and cloning techniques, transfected into human embryo kidney (HEK) 293A cells to product adenovirus, and then was used to infect the HEK293A cells to amplify the adenoviral stock.
  • Normal human thyrocytes fart from thyroid adenoma were obtained during resection of adenoma, cultured, and infected by the GSK-3beta specific RNAi adenovirus.
  • BrdU method was used to detect the cell proliferation.
  • Another HEK293A cells were divided into 3 groups: infected with recombinant adenovirus plasmid Ad-1457, infected with un-recombinant framework plasmid pAd-DEST, and un-infected.
  • RESULTS: The GSK-3beta expression of the thyrocytes infected with the recombinant adenovirus plasmid Ad-1457 were significantly lower than those of the thyrocytes infected with Ad-DEST (all P<0.05).
  • The expression of beta-catenin of the thyrocytes infected with Ad-DEST was significantly higher than those of the Ad-DEST group and un-infected group (both P<0.05).
  • [MeSH-major] Cell Proliferation. Glycogen Synthase Kinase 3 / genetics. RNA Interference. Thyroid Gland / cytology. Wnt Proteins / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adenoviridae. Cell Line. Genetic Vectors. Humans

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  • (PMID = 19080489.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin; EC 2.7.11.26 / Glycogen Synthase Kinase 3
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74. Trepp R, Padberg BC, Varga Z, Cathomas R, Inauen R, Reinhart WH: Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation. Pathol Res Pract; 2010 May 15;206(5):334-7
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  • [Title] Extensive extranodal metastases of basal-like breast cancer with predominant myoepithelial spindle cell differentiation.
  • These include multifocal myoepitheliomatosis, the rare mixed tumor or pleomorphic adenoma, adenoid cystic carcinoma, adenomyoepithelioma and myoepithelial carcinoma (malignant myoepithelioma).
  • All these tumors are benign and/or of low-grade malignancy, with the exception of malignant myoepithelioma.
  • The presented case of a breast carcinoma with dominant myoepithelial/spindle cell differentiation in a 58-year-old woman is an excellent example to document the highly aggressive biological behavior of this tumor phenotype.
  • Similarities in morphology and biological behavior compared to patients with "triple-negative" (hormone receptor and Her2) monophasic sarcomatoid carcinomas and pure spindle cell sarcomas are discussed.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / secondary. Kidney Neoplasms / secondary. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic / pathology. Fatal Outcome. Female. Humans. Middle Aged


75. Agrawal S, Jha MS, Khurana N, Ansari MS, Dubey D, Srivastava A, Kapoor R, Kumar A, Jain M, Mandhani A: Nephron sparing surgery: A single institution experience. Indian J Urol; 2007 Jan;23(1):23-7
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  • OBJECTIVE: To report our experience in managing various benign and malignant renal tumors with nephron-sparing surgery.
  • RESULTS: There were 26 patients (29 renal units), including three with bilateral lesions who underwent nephron-sparing surgery.
  • Histopathological profile revealed 13 (44.8%) benign lesions which included angiomyolipoma (eight), simple cyst (two), cortical adenoma (one), metanephric adenoma (one) and myelolipoma (one).
  • The remaining 16 (55.2%) malignant lesions included renal cell carcinoma (15) and metastatic adenocarcinoma (one).
  • CONCLUSIONS: Nephron-sparing surgery is a safe and effective alternative to nephrectomy in both benign and malignant lesions of the kidney.

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  • (PMID = 19675756.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2721489
  • [Keywords] NOTNLM ; Kidney / kidney diseases / nephron sparing surgery
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76. Memeo L, Jhang J, Assaad AM, McKiernan JM, Murty VV, Hibshoosh H, Tong GX, Mansukhani MM: Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma. Am J Clin Pathol; 2007 Feb;127(2):225-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma.
  • Immunohistochemical staining for cytokeratin 7 (CK7), KIT, and PAX2 expression was performed on 91 renal neoplasms, 37 conventional (clear cell) renal cell carcinomas (CRCCs), 20 papillary RCCs (PRCCs), 11 chromophobe RCCs (ChCs), and 23 oncocytomas, with available karyotypes.
  • These results identify specific staining patterns of the 4 major histologic subtypes of renal neoplasms and raise the question of a relationship between chromosome 10 loss and loss of PAX2 expression in ChC.
  • [MeSH-major] Carcinoma, Renal Cell / chemistry. Keratin-7 / analysis. Kidney Neoplasms / chemistry. PAX2 Transcription Factor / analysis. Proto-Oncogene Proteins c-kit / analysis
  • [MeSH-minor] Adenoma, Oxyphilic / chemistry. Cytogenetic Analysis. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 17210525.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Keratin-7; 0 / PAX2 Transcription Factor; 0 / PAX2 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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77. Young AN: Editorial comment from Dr Young to Molecular pathology of renal oncocytoma: A review. Int J Urol; 2010 Jul;17(7):612-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Editorial comment from Dr Young to Molecular pathology of renal oncocytoma: A review.
  • [MeSH-major] Adenoma, Oxyphilic. Kidney Neoplasms

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  • [CommentOn] Int J Urol. 2010 Jul;17(7):602-12 [20590944.001]
  • (PMID = 20590945.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Australia
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78. TAIPAI Study Group, Wu VC, Chueh SC, Chang HW, Lin LY, Liu KL, Lin YH, Ho YL, Lin WC, Wang SM, Huang KH, Hung KY, Kao TW, Lin SL, Yen RF, Chen YM, Hsieh BS, Wu KD: Association of kidney function with residual hypertension after treatment of aldosterone-producing adenoma. Am J Kidney Dis; 2009 Oct;54(4):665-73
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  • [Title] Association of kidney function with residual hypertension after treatment of aldosterone-producing adenoma.
  • BACKGROUND: Autonomous secretion of aldosterone in patients with primary aldosteronism increases glomerular filtration rate and causes kidney damage.
  • The influence of a mild decrease in kidney function on residual hypertension after adrenalectomy is unexplored.
  • 150 patients (61 men; overall mean age, 47.2 +/- 11.6 years) with a diagnosis of aldosterone-producing adenoma had undergone unilateral adrenalectomy at National Taiwan University Hospital from July 1999 to January 2007.
  • CONCLUSIONS: Two-thirds of patients with aldosterone-producing adenoma were cured of hypertension by means of unilateral adrenalectomy.
  • Kidney function impairment, even mild, appears to be associated with a high incidence of postsurgery residual hypertension.
  • [MeSH-major] Adenoma / physiopathology. Adrenal Cortex Neoplasms / physiopathology. Adrenalectomy. Aldosterone / blood. Glomerular Filtration Rate. Hypertension / physiopathology. Kidney / physiopathology
  • [MeSH-minor] Adult. Blood Pressure. Creatinine / blood. Female. Humans. Hyperaldosteronism / blood. Hyperaldosteronism / etiology. Hyperaldosteronism / metabolism. Hyperaldosteronism / physiopathology. Kidney Function Tests. Male. Middle Aged. Odds Ratio. Retrospective Studies. Severity of Illness Index

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  • [CommentIn] Am J Kidney Dis. 2009 Oct;54(4):594-7 [19781452.001]
  • (PMID = 19628318.001).
  • [ISSN] 1523-6838
  • [Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation
  • [ISO-abbreviation] Am. J. Kidney Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 4964P6T9RB / Aldosterone; AYI8EX34EU / Creatinine
  • [Investigator] Wu VC; Lin YH; Ho YL; Chang HW; Lin LY; Hu FC; Liu KL; Wang SM; Huang KH; Chang FC; Chen YM; Kuo CC; Chueh SC; Lu CC; Chang FC; Liao SC; Yen RF; Lin WC; Hsieh BS; Wu KD; Hsien FF
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79. Picken MM, Chyna B, Flanigan RC, Lee JM: Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization. Am J Clin Pathol; 2008 Mar;129(3):377-82
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  • [Title] Analysis of chromosome 1p abnormalities in renal oncocytomas by loss of heterozygosity studies: correlation with conventional cytogenetics and fluorescence in situ hybridization.
  • We previously showed by cytogenetics and fluorescence in situ hybridization (FISH) that the most common chromosomal abnormality in renal oncocytomas is loss of chromosome 1 or 1p.
  • LOH was detected in at least 1 locus in 12 (86%) of 14 renal oncocytomas studied, with other loci being noninformative or not interpretable (1 case).
  • These results provide further evidence to support widespread abnormalities in chromosome 1p in renal oncocytoma.
  • Determining whether such abnormalities are unique to renal oncocytomas or are also present in other tumors requires further studies.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Chromosomes, Human, Pair 1 / genetics. Kidney Neoplasms / genetics

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  • (PMID = 18285259.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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80. Yokohira M, Yamakawa K, Hosokawa K, Matsuda Y, Kuno T, Saoo K, Imaida K: Promotion potential of madder color in a medium-term multi-organ carcinogenesis bioassay model in F344 rats. J Food Sci; 2008 Apr;73(3):T26-32
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  • In the kidneys, incidences (and numbers) of adenoma treated with 5.0% and 2.5%, 47.4% (0.20 +/- 0.24), and 47.4% (0.13 +/- 0.15) (groups 1 and 2) were significantly increased compared to control, 0% (0) (group 3).
  • [MeSH-major] Carcinogenicity Tests. Carcinogens / toxicity. Kidney Neoplasms / chemically induced. Liver Neoplasms, Experimental / chemically induced. Plant Extracts / toxicity. Rubia / toxicity
  • [MeSH-minor] Adenoma / chemically induced. Adenoma / pathology. Animals. Biological Assay. Dose-Response Relationship, Drug. Male. Neoplasms, Experimental / chemically induced. Neoplasms, Experimental / pathology. Random Allocation. Rats. Rats, Inbred F344

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  • (PMID = 18387132.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Plant Extracts; 0 / madder color
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81. Schmidt LS, Nickerson ML, Warren MB, Glenn GM, Toro JR, Merino MJ, Turner ML, Choyke PL, Sharma N, Peterson J, Morrison P, Maher ER, Walther MM, Zbar B, Linehan WM: Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. Am J Hum Genet; 2005 Jun;76(6):1023-33
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  • Birt-Hogg-Dubé syndrome (BHD), a genodermatosis characterized by multiple hamartomas of the hair follicle (fibrofolliculoma), predisposes individuals to an increased risk of developing renal neoplasms and spontaneous pneumothorax.
  • Among patients with a mutation in the exon 11 hotspot, significantly fewer renal tumors were observed in patients with the C-deletion than those with the C-insertion mutation.
  • Of the 53 families with BHD whose members inherited either a germline mutation or the affected haplotype, 24 (45%) had at least one member with renal neoplasms.
  • Three families classified with familial renal oncocytoma were identified with BHD mutations, which represents the first disease gene associated with this rare form of renal neoplasm.

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  • (PMID = 15852235.001).
  • [ISSN] 0002-9297
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] ENG
  • [Databank-accession-numbers] OMIM/ 135150
  • [Grant] United States / PHS HHS / / N01-C0-12400
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FLCN protein, human; 0 / Proteins; 0 / Proto-Oncogene Proteins; 0 / Tumor Suppressor Proteins
  • [Other-IDs] NLM/ PMC1196440
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82. Dann P, Thakur R, Chin D, Krinsky G, Israel GM: Are T2-weighted images necessary in renal mass characterization? Eur J Radiol; 2006 Jul;59(1):112-6
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  • [Title] Are T2-weighted images necessary in renal mass characterization?
  • OBJECTIVE: To determine what role T2-weighted images play in characterizing renal masses.
  • METHODS: Forty-four pathologically proven renal masses (34 renal cell carcinomas, 8 oncocytomas, 1 metanephric adenoma, 1 angiomyolipoma without macroscopic fat) and 38 simple renal cysts were evaluated with T1- and T2-weighted images at 1.5T.
  • RESULTS: Forty-three of the 44 (98%) pathologically proven renal masses were characterized as a surgical mass using only the T1-weighted images.
  • The remaining renal mass (a renal cell carcinoma) was characterized as a mass in which follow-up exams would be suggested.
  • Thirty-eight of 38 (100%) simple renal cysts were correctly characterized using only the T1-weighted images.
  • CONCLUSION: The results of this study suggest that T2-weighted images are not necessary in the evaluation of all renal masses and are specifically not necessary in the differentiation of solid and cystic renal neoplasms from simple renal cysts.
  • [MeSH-major] Kidney Diseases / diagnosis. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Aged. Contrast Media. Diagnosis, Differential. Female. Gadolinium DTPA. Humans. Kidney Diseases, Cystic / diagnosis. Kidney Neoplasms / diagnosis. Male. Middle Aged

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  • (PMID = 16530371.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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83. McHugh JB, Hoschar AP, Dvorakova M, Parwani AV, Barnes EL, Seethala RR: p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol; 2007 Dec;1(2):123-31
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  • [Title] p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.
  • Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions.
  • Morphologic features evaluated were cytoplasmic character (clear versus oncocytic), Fuhrman nuclear grade, mitotic rate, growth pattern, presence of lumens/blood lakes and stromal characteristics.
  • Tumors were stained with antibodies to p63, renal cell carcinoma marker (RCCm), CD10, and vimentin.
  • Eight benign oncocytic tumors (29%) had clear cell features while 6 metastatic RCC (37%) had oncocytic features.
  • Mitotic rates were only significantly different between benign oncocytic tumors and metastatic RCC.
  • Seven benign oncocytic tumors (25%) and 5 oncocytic carcinomas (56%) had RCC-like vascular stroma.
  • All primary salivary gland tumors were positive for p63, predominately in basal cell-type distribution.
  • While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity.
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma, Renal Cell / diagnosis. Kidney Neoplasms / diagnosis. Membrane Proteins / metabolism. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Predictive Value of Tests

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  • (PMID = 20614263.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2807526
  • [Keywords] NOTNLM ; Metastatic renal cell carcinoma / Oncocytic carcinoma / Oncocytoma / p63
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84. Kochhar R, Brown RK, Wong CO, Dunnick NR, Frey KA, Manoharan P: Role of FDG PET/CT in imaging of renal lesions. J Med Imaging Radiat Oncol; 2010 Aug;54(4):347-57
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  • [Title] Role of FDG PET/CT in imaging of renal lesions.
  • Focal incidental renal lesions are commonly encountered on positron emission tomography (PET)/computed tomography (CT) imaging.
  • The vast majority of these lesions are benign.
  • However, the interpretation of renal lesions can be problematic if the imaging criteria of simple cysts are not met.
  • Limited literature exists on the characterisation of renal masses with metabolic imaging.
  • The purpose of this article is to focus on the imaging features of benign and malignant renal masses with PET/CT.
  • The lesions discussed include renal cyst, angiomyolipoma, oncocytoma, renal cell carcinoma, renal metastases and other infiltrating neoplastic processes affecting the kidney.
  • Both the anatomical and metabolic features which characterise these benign and malignant entities are described.
  • We emphasise the importance of viewing the CT component to identify the typical morphological features and discuss how to best use hybrid imaging for management of renal lesions.
  • Metabolic imaging has a promising role in the imaging of renal lesions and can help prevent unnecessary biopsies and ensure optimal management of suspicious lesions.
  • [MeSH-major] Carcinoma, Renal Cell / diagnosis. Fluorodeoxyglucose F18. Kidney Neoplasms / diagnosis. Positron-Emission Tomography / methods. Radiopharmaceuticals. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenoma, Oxyphilic / diagnosis. Angiomyolipoma / diagnosis. Cysts / diagnosis. Humans. Incidental Findings. Kidney / radiography. Kidney / radionuclide imaging. Kidney Diseases / diagnosis. Leukemia / diagnosis. Lymphoma / diagnosis

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  • (PMID = 20718915.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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85. Sibony M, Vieillefond A: [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology]. Ann Pathol; 2008 Oct;28(5):381-401
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  • [Title] [Non clear cell renal cell carcinoma. 2008 update in renal tumor pathology].
  • [Transliterated title] Les tumeurs du rein qui ne sont pas des carcinomes à cellules claires. Etat des lieux en 2008.
  • Non clear cell renal cell carcinomas represent almost 20% of all renal neoplasms.
  • Since molecular techniques are expensive, diagnosis still relies on morphological and immuno-histochemical criteria detailed hereby.
  • Papillary renal cell carcinomas are the most important group and its classification is more and more complex.
  • It encompasses low-grade papillary carcinomas (type 1 papillary renal cell carcinoma, oncocytic papillary renal cell carcinoma) and high-grade papillary carcinomas (type 2 papillary renal cell carcinoma, juvenile papillary carcinoma corresponding to renal carcinoma associated with Xp11.2 translocations and unclassified carcinomas).
  • Mucinous tubular and spindle cell carcinoma and tubulocystic carcinoma are new entities, actually considered by some authors as low-grade papillary carcinomas.
  • The so-called carcinoma of collecting ducts of Bellini and renal medullary carcinoma should be considered as intrarenal urothelial carcinoma or as high-grade papillary or unclassified carcinoma.
  • Sarcomatoid carcinoma derives from morphological progression of any type of renal cell carcinoma.
  • The group of oncocytomas/chromophobe renal cell carcinomas can be considered as a spectrum from benign (oncocytoma) to malignant neoplasm (chromophobe renal cell carcinoma).
  • Angiomyolipoma is usually a benign mesenchymatous neoplasm, that can be sporadic or familial (tuberous sclerosis).
  • Renal epithelial and stromal tumors (REST) is a new concept gathering two benign mixed mesenchymal and epithelial tumors: cystic nephroma and mixed epithelial and stromal tumors (MEST).
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adenoma, Oxyphilic / classification. Adenoma, Oxyphilic / genetics. Adenoma, Oxyphilic / pathology. Carcinoma / classification. Carcinoma / genetics. Carcinoma / pathology. Chromosome Mapping. Chromosomes, Human. Humans. Immunohistochemistry. Kidney / pathology. Kidney Tubules, Collecting / pathology. Necrosis


86. Khan MK, Taous A, Sultana SZ, Sharif A, Hossain MM, Mostafa G, Hussain MA, Azim MA, Siddique MA: Neck swelling with renal stone. Mymensingh Med J; 2010 Oct;19(4):622-6
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  • [Title] Neck swelling with renal stone.
  • Although in the past, most patients present with severe bone and renal diseases, a large number of patients are asymptomatic.
  • Parathyroid adenoma or hyperplasia may be a part of Multiple Endocrine neoplasia type II.
  • After search, hypercalcaemia, bilateral renal stone, raised parathormone level and enlarged one parathyroid gland in lower pole of left thyroid lobe was identified.
  • Clinically it was diagnosed as parathyroid adenoma which was proved histologically after surgical excision.
  • Many controversies still exist regarding the treatment policy of parathyroid adenoma.

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  • (PMID = 20956910.001).
  • [ISSN] 1022-4742
  • [Journal-full-title] Mymensingh medical journal : MMJ
  • [ISO-abbreviation] Mymensingh Med J
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Bangladesh
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87. Burger M, Denzinger S, Filbeck T, Hartmann A, Rössler W, Hammerschmied C: A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature. ScientificWorldJournal; 2005 Jul 20;5:545-9
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  • [Title] A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature.
  • We present one case of a metachronous, atypical, multifocal renal oncocytoma with a concomitant chromophobe renal cell carcinoma (RCC) of the contralateral side and one case of bilateral and multifocal oncocytomas.
  • Oncocytomas are benign renal tumours that rarely appear bilateral or multifocal or with coexisting RCC.
  • The first case was a 63 years old patient presenting with a history of nephrectomy for a pT1 G1 pN0 R0 papillary RCC 4 years prior to presentation, showed two tumours of a singular kidney.
  • The second case was a 62 years old patient presenting with multifocal and bilateral renal tumours of undeclared dignity upon imaging.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Chromosome Deletion. Chromosomes, Human, Pair 1 / ultrastructure. Chromosomes, Human, Pair 10 / ultrastructure. DNA, Neoplasm / genetics. Diagnosis, Differential. Follow-Up Studies. Humans. Incidental Findings. Middle Aged. Nephrectomy / methods. Nucleic Acid Hybridization. Remission Induction

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  • (PMID = 16075151.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Number-of-references] 12
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88. Kruse A, Beige J: [Hyperparathyroidism--new aspects]. Ther Umsch; 2007 May;64(5):265-9
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  • The mainstay of secondary HPT is the initial vitamin D deficiency such as associated with kidney failure.
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / physiopathology. Adenoma / therapy. Hyperplasia. Parathyroid Glands / pathology. Parathyroid Neoplasms / diagnosis. Parathyroid Neoplasms / physiopathology. Parathyroid Neoplasms / therapy. Parathyroidectomy. Receptors, Calcium-Sensing / drug effects. Receptors, Calcium-Sensing / physiology. Vitamin D / therapeutic use

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  • (PMID = 17685085.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Parathyroid Hormone; 0 / Receptors, Calcium-Sensing; 1406-16-2 / Vitamin D; SY7Q814VUP / Calcium
  • [Number-of-references] 17
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89. Fromont G, Barcat L, Gaudin J, Irani J: Revisiting the immunophenotype of nephrogenic adenoma. Am J Surg Pathol; 2009 Nov;33(11):1654-8
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  • [Title] Revisiting the immunophenotype of nephrogenic adenoma.
  • Nephrogenic adenoma (NA) is a rare benign lesion of the urinary tract.
  • Although its histogenesis is still debated, several reports suggest that the lesion has a renal tubular cell origin or differentiation.
  • Because all the previous studies have used an avidin-biotin (AB) detection procedure, and because cells with tubular renal differentiation are likely to contain a high level of endogenous biotin, we investigated in NA the expression of several markers including AMACR, using both AB and biotin-free detection systems.
  • We assessed the expression of p63, cytokeratins 7 and 20, CD10 (proximal tubule marker), MUC1 (distal tubule marker), PAX2, and AMACR on 14 NAs (from 6 patients) grouped on a tissue microarray.
  • The tissue microarray also included renal, urothelial, and prostate tissues.
  • Detection with the AB procedure leads to nonspecific staining in kidney samples and NA.
  • These findings provide supporting evidence that NA has the differentiation of distal renal tubules, and strongly suggest that AMACR, when detected with a biotin-free procedure, can be used as a reliable marker for distinguishing NA from prostate cancer.
  • [MeSH-major] Adenoma / immunology. Immunophenotyping / methods. Urologic Neoplasms / immunology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Child. Diagnosis, Differential. Female. Fluorescent Antibody Technique, Indirect. Humans. Kidney Tubules / enzymology. Male. Middle Aged. Prostatic Neoplasms / diagnosis. Racemases and Epimerases / metabolism. Tissue Array Analysis

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  • (PMID = 19730362.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
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90. Bahar G, Feinmesser R, Joshua BZ, Shpitzer T, Morgenstein S, Popovtzer A, Shvero J: Hyperfunctioning intrathyroid parathyroid gland: a potential cause of failure in parathyroidectomy. Surgery; 2006 Jun;139(6):821-6
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  • Their files were reviewed for clinical features, surgical approach, intraoperative findings, parathyroid gland location, and morphologic and histopathologic characteristics.
  • The diagnosis in all patients was based on an increase in serum calcium concentration (10.1-13 mg/100 mL) and parathyroid hormone level (102-320 pg/mL).
  • The clinical symptoms were kidney stones, gastrointestinal complaints, hypertension, and osteopenia.
  • Adenoma was diagnosed histologically in 4 patients; 2 had a double adenoma.

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  • (PMID = 16782440.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Surgit O: Clipless and sutureless laparoscopic adrenalectomy carried out with the LigaSure device in 32 patients. Surg Laparosc Endosc Percutan Tech; 2010 Apr;20(2):109-13
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  • In 1 patient the adrenal tumor had invaded the ipsilateral kidney, so laparoscopic nephrectomy was also carried out during the same operation.
  • In another patient, a renal cell carcinoma in the left kidney had metastasized to the right adrenal gland.
  • Both the kidney and the contralateral adrenal gland were removed laparoscopically during the same operation.
  • Adrenal tumor types included adrenocortical adenoma (16 patients), pheochromocytoma (13 patients), malignant pheochromocytoma (1 patient), chromophobic carcinoma (1 patient), and metastasis from a renal cell carcinoma (1 patient).
  • For patients with conditions such as renal cell carcinoma combined with metastasis to the contralateral adrenal gland, nephrectomy, and contralateral adrenalectomy can be carried out during the same laparoscopic operation.
  • [MeSH-minor] Adenoma, Chromophobe / surgery. Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Adrenocortical Adenoma / surgery. Adult. Aged. Blood Loss, Surgical. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Female. Humans. Kidney Neoplasms / surgery. Male. Middle Aged. Nephrectomy / methods. Pheochromocytoma / surgery

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  • (PMID = 20393338.001).
  • [ISSN] 1534-4908
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Urge T, Hes O, Ferda J, Chudácek Z, Eret V, Michal M, Brunelli M, Martignoni G, Hora M: Typical signs of oncocytic papillary renal cell carcinoma in everyday clinical praxis. World J Urol; 2010 Aug;28(4):513-7
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  • [Title] Typical signs of oncocytic papillary renal cell carcinoma in everyday clinical praxis.
  • PURPOSE: Types 1 and 2 by Delahunt of papillary renal cell carcinoma (PRCC) are traditionally differentiated.
  • METHODS: From 1/1992 to 10/2009, 1,398 patients with 1,436 renal tumours were surgically treated in our institution.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Carcinoma, Papillary / pathology. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Adrenalectomy. Aged. Biopsy. Cell Differentiation. Female. Humans. Male. Middle Aged. Necrosis. Nephrectomy. Tomography, X-Ray Computed


93. Bhutta MF, Dunk L, Molyneux AJ, Tewary A: Parotid pleomorphic adenoma with solitary renal metastasis. Br J Oral Maxillofac Surg; 2010 Jan;48(1):61-3
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  • [Title] Parotid pleomorphic adenoma with solitary renal metastasis.
  • We present a rare case of renal metastasis of a recurrent pleomorphic adenoma of the parotid gland in an elderly woman.
  • Metastasising pleomorphic adenoma shows malignant clinical behaviour, and although it appears histologically benign, there may be unknown molecular features that determine its unusual ability to spread.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Kidney Neoplasms / secondary. Parotid Neoplasms / pathology

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19386401.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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94. Petillo D, Kort EJ, Anema J, Furge KA, Yang XJ, Teh BT: MicroRNA profiling of human kidney cancer subtypes. Int J Oncol; 2009 Jul;35(1):109-14
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  • [Title] MicroRNA profiling of human kidney cancer subtypes.
  • In order to understand their role in renal tumorigenesis, we screened the expression levels of miRNAs in four subtypes of human renal neoplasms: clear cell, papillary, and chromophobe renal cell carcinomas (RCC) as well as benign renal oncocytomas.
  • We found a unique miRNA signature for each subtype of renal tumor.
  • Furthermore, we identified unique patterns of miRNA expression distinguishing clear cell RCC cases with favorable vs. unfavorable outcome.
  • Specifically, we documented the overexpression of miRs 424 and 203 in clear cell RCC relative to papillary RCC, as well as the inversion of expression of miR-203 in the benign oncocytomas (where it is underexpressed relative to normal kidney) as compared to the malignant chromophobe RCC (where it is overexpressed relative to normal kidney).
  • [MeSH-major] Adenoma, Oxyphilic / genetics. Carcinoma, Renal Cell / genetics. Gene Expression Profiling / methods. Kidney Neoplasms / genetics. MicroRNAs / analysis

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  • (PMID = 19513557.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / MicroRNAs
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95. Gasparre G, Hervouet E, de Laplanche E, Demont J, Pennisi LF, Colombel M, Mège-Lechevallier F, Scoazec JY, Bonora E, Smeets R, Smeitink J, Lazar V, Lespinasse J, Giraud S, Godinot C, Romeo G, Simonnet H: Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma. Hum Mol Genet; 2008 Apr 1;17(7):986-95
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  • [Title] Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma.
  • Here we show a benign tumor type in which mtDNA mutations that lead to complex I (CI) enzyme deficiency are found in all tumors and are the only genetic alteration detected.
  • Actually renal oncocytomas are homogeneous tumors characterized by dense accumulation of mitochondria and we had found that they are deficient in electron transport chain complex I (CI, NADH-ubiquinone oxidoreductase).
  • We hypothesize that functional deficiency of the oxidative phosphorylation CI could create a loop of amplification of mitochondria during cell division, impair substrates oxidation and increase intermediary metabolites availability.
  • [MeSH-major] Adenoma, Oxyphilic / genetics. DNA, Mitochondrial / genetics. Electron Transport Complex I / genetics. Kidney Neoplasms / genetics
  • [MeSH-minor] Cell Culture Techniques. Cell Nucleus / genetics. Cell Proliferation. Citrate (si)-Synthase / metabolism. DNA Mutational Analysis. DNA-Directed DNA Polymerase / genetics. Electron Transport Chain Complex Proteins / genetics. Electron Transport Chain Complex Proteins / metabolism. Gene Amplification. Glucose / metabolism. Humans. Hypoxia-Inducible Factor 1, alpha Subunit / genetics. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. NADH Dehydrogenase / metabolism. Nucleic Acid Hybridization. Oxidative Phosphorylation. RNA, Messenger / genetics. RNA, Messenger / metabolism. Sequence Analysis, DNA

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  • (PMID = 18156159.001).
  • [ISSN] 1460-2083
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Mitochondrial; 0 / Electron Transport Chain Complex Proteins; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; EC 1.6.5.3 / Electron Transport Complex I; EC 1.6.99.3 / NADH Dehydrogenase; EC 2.3.3.1 / Citrate (si)-Synthase; EC 2.7.7.- / POLG protein, human; EC 2.7.7.7 / DNA-Directed DNA Polymerase; IY9XDZ35W2 / Glucose
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96. Kim JI, Cho JY, Moon KC, Lee HJ, Kim SH: Segmental enhancement inversion at biphasic multidetector CT: characteristic finding of small renal oncocytoma. Radiology; 2009 Aug;252(2):441-8
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  • [Title] Segmental enhancement inversion at biphasic multidetector CT: characteristic finding of small renal oncocytoma.
  • PURPOSE: To retrospectively determine the usefulness of segmental enhancement inversion during the corticomedullary phase (CMP) and early excretory phase (EEP) of biphasic multidetector computed tomography (CT) in differentiating small renal oncocytoma from renal cell carcinoma (RCC).
  • Between January 2004 and December 2006, 98 patients with pathologically confirmed renal masses smaller than 4 cm (10 renal oncocytomas and 88 RCCs) were included in this study.
  • The Fisher exact test was used to determine the significance of segmental enhancement inversion in differentiating small renal oncocytoma from RCC.
  • RESULTS: Eight of 10 renal oncocytomas and only one of 88 RCCs showed segmental inversion during CMP and EEP, which significantly differentiated small renal oncocytomas and RCCs (P < .0001).
  • CONCLUSION: Segmental enhancement inversion during CMP and EEP was found to be a characteristic enhancement pattern of small renal oncocytoma at biphasic multidetector CT and it may help in differentiating small oncocytoma from RCC.
  • [MeSH-major] Adenoma, Oxyphilic / radiography. Carcinoma, Renal Cell / radiography. Kidney Neoplasms / radiography. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 19508984.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Alroy J, Ucci AA, Azabdoaftari G, Banner BF, Cheville JC: Expression of CD3 antigens in renal tubule epithelium and renal oncocytomas. Pathol Res Pract; 2005;201(12):803-8
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  • [Title] Expression of CD3 antigens in renal tubule epithelium and renal oncocytomas.
  • The antibodies commonly used to recognize CD3 are directed against the epsilon-subunit of the T cell receptor.
  • We immunostained sections for CD3 from normal kidneys of several species, including humans, and from different primary human renal cortical neoplasms to determine if CD3 antigen is expressed in normal and in neoplastic tubular epithelium.
  • CD3 expression was strong in normal proximal and distal tubular epithelium in most species and in renal oncocytomas, weak in chromophobe carcinoma, and negative in clear cell carcinomas, in papillary renal cell carcinoma, and in a transitional cell carcinoma.
  • These findings suggest that this marker may be useful in the diagnostic workup and classification of renal cortical neoplasms.
  • [MeSH-major] Adenoma, Oxyphilic / metabolism. Antigens, CD3 / metabolism. Kidney Neoplasms / metabolism. Kidney Tubules / metabolism

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  • (PMID = 16308105.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD3
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98. Woodard GE, Lin L, Zhang JH, Agarwal SK, Marx SJ, Simonds WF: Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene; 2005 Feb 10;24(7):1272-6
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  • A survey of human and mouse tissues analysed with polyclonal antibodies to parafibromin showed specific immunoreactivity in adrenal and parathyroid glands, kidney, heart, and skeletal muscle.
  • Parafibromin was expressed in four parathyroid adenomas but was absent from two parathyroid carcinomas.
  • Transient overexpression of wild-type parafibromin, but not its Leu64Pro missense mutant implicated in parathyroid cancer and familial isolated hyperparathyroidism, inhibited cell proliferation, and blocked expression of cyclin D1, a key cell cycle regulator previously implicated in parathyroid neoplasia.
  • [MeSH-major] Adenoma / metabolism. Carcinoma / metabolism. Cyclin D1 / biosynthesis. Down-Regulation. Parathyroid Neoplasms / metabolism. Proteins / physiology. Tumor Suppressor Proteins / physiology
  • [MeSH-minor] Animals. COS Cells. Cell Nucleus / immunology. Cell Proliferation. Cercopithecus aethiops. Cytoplasm / immunology. Humans. Mice. Mutation, Missense / genetics. Parathyroid Glands / immunology. Parathyroid Glands / metabolism. Transfection


99. Yamashita R, Nakamura M, Matsuzaki M, Matsui T, Yamaguchi R, Niwakawa M, Tobisu K, Asakura K, Ito I: [Clinical factors associated with benign renal tumors]. Nihon Hinyokika Gakkai Zasshi; 2009 Nov;100(7):679-85
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  • [Title] [Clinical factors associated with benign renal tumors].
  • OBJECTIVES: In this study, we sought to define the incidence of benign renal tumors in our institute and to clarify the clinical factors associated with benign renal tumors, in order to assist in forming preoperative differential diagnoses.
  • METHODS: From October 2002 to July 2007, we performed 157 nephrectomies in patients preoperatively diagnosed with renal cell carcinoma.
  • We also compared clinical factors, including age, sex and tumor size, between the benign and malignant renal tumors.
  • Benign renal tumors were found in 10 (12%) of the 81 tumors; these included seven cases of oncocytoma and three cases of angiomyolipoma with minimal fat.
  • Several factors were significant clinical determinants of differentiation between benign and malignant renal tumors: homogeneity in CT, female gender, and small tumor size all predominated in cases of benign tumors.
  • CONCLUSIONS: When a patient, especially a female, presents with a small and homogeneous renal tumor, careful consideration should be given to the possibility of a benign process, which needs further consideration before performing excessive surgery.
  • [MeSH-major] Adenoma, Oxyphilic. Angiomyolipoma. Kidney Neoplasms
  • [MeSH-minor] Age Factors. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Sex Factors. Tomography, Spiral Computed

  • MedlinePlus Health Information. consumer health - Kidney Cancer.
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  • (PMID = 19999132.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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100. Liu L, Qian J, Singh H, Meiers I, Zhou X, Bostwick DG: Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. Arch Pathol Lab Med; 2007 Aug;131(8):1290-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis.
  • CONTEXT: The separation of chromophobe renal cell carcinoma, oncocytoma, and clear cell renal cell carcinoma using light microscopy remains problematic in some cases.
  • OBJECTIVE: To determine a practical immunohistochemical panel for the differential diagnosis of chromophobe carcinoma.
  • DESIGN: Vimentin, glutathione S-transferase alpha (GST-alpha), CD10, CD117, cytokeratin (CK) 7, and epithelial cell adhesion molecule (EpCAM) were investigated in 22 cases of chromophobe carcinoma, 17 cases of oncocytoma, and 45 cases of clear cell carcinoma.
  • RESULTS: Vimentin and GST-alpha expression were exclusively observed in clear cell carcinoma.
  • CD10 staining was more frequently detected in clear cell carcinoma (91%) than in chromophobe carcinoma (45%) and oncocytoma (29%).
  • CD117 was strongly expressed in chromophobe carcinoma (82%) and oncocytoma (100%), whereas none of the cases of clear cell carcinomas were immunoreactive.
  • EpCAM protein was expressed in all 22 cases of chromophobe carcinoma in more than 90% of cells, whereas all EpCAM-positive oncocytomas (5/17; 29%) displayed positivity in single cells or small cell clusters.
  • CONCLUSIONS: Using the combination of 3 markers (vimentin, GST-alpha, and EpCAM), we achieved 100% sensitivity and 100% specificity for the differential diagnosis of chromophobe carcinoma, oncocytoma, and clear cell carcinoma.
  • The pattern of "vimentin(-)/GST-alpha(-)" effectively excluded clear cell carcinoma, and homogeneous EpCAM expression confirmed the diagnosis of chromophobe carcinoma rather than oncocytoma.
  • CD117 and CK7 were also useful markers and could be used as second-line markers for the differential diagnosis, with high specificity (100%) and high sensitivity (90% and 86%, respectively).
  • [MeSH-major] Adenocarcinoma, Clear Cell / diagnosis. Adenoma, Oxyphilic / diagnosis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Immunoenzyme Techniques / methods. Kidney Neoplasms / diagnosis. Neoplasm Proteins / analysis
  • [MeSH-minor] Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Humans. Predictive Value of Tests






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